evidence_pass,evidence_status,failure_reasons,positive_evidence_inside,positive_evidence_reproductive,selectivity_gate_applied,selectivity_exclusions,manageable_worst_selectivity_margin,protected_worst_selectivity_margin,vital_worst_selectivity_margin,rna_routine_missing,ihc_routine_missing,ihc_coverage,vital_rna_max_ntpm,protected_rna_max_ntpm,manageable_rna_max_ntpm,rna_exclusions,ihc_exclusions,ihc_forbidden_contexts_observed,absence_evidence,tissue_review_status,tissue_review_flags,tissue_review_contexts,historical_nomination_review_eligible,historical_nomination_review_reason,nomination_review_eligible,nomination_review_reason,screen_review_superseded_holdback,screen_review_warning,screen_review_reference,Ensembl_Gene_ID,Symbol,scenario,family_eligible,screen_review_applied,retained,previous_retained,source_dois,source_publications
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 84.7458% (minimum 95%, Missing); adrenal gland: 90.0901% (minimum 99%, Missing); amygdala: 94.3396% (minimum 99%, Missing); basal ganglia: 94.3396% (minimum 99%, Missing); bone marrow: 52.9101% (minimum 99%, Missing); cerebellum: 76.9231% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 99%, Missing); choroid plexus: 94.3396% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); duodenum: 89.2857% (minimum 99%, Uncertain); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 91.7431% (minimum 99%, Missing); hippocampal formation: 92.5926% (minimum 99%, Missing); hypothalamus: 93.4579% (minimum 99%, Missing); kidney: 90.9091% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lung: 86.2069% (minimum 99%, Missing); lymph node: 61.7284% (minimum 97%, Missing); midbrain: 93.4579% (minimum 99%, Missing); pancreas: 87.7193% (minimum 99%, Missing); parathyroid gland: 43.4783% (minimum 97%, Missing); pituitary gland: 90.9091% (minimum 99%, Missing); rectum: 71.4286% (minimum 97%, Uncertain); retina: 65.3595% (minimum 99%, Missing); salivary gland: 86.9565% (minimum 97%, Missing); skeletal muscle: 91.7431% (minimum 99%, Missing); skin: 80.6452% (minimum 95%, Missing); small intestine: 84.7458% (minimum 99%, Uncertain); smooth muscle: 79.3651% (minimum 99%, Missing); spinal cord: 88.4956% (minimum 99%, Missing); spleen: 78.7402% (minimum 95%, Missing); stomach: 84.7458% (minimum 97%, Missing); thymus: 46.9484% (minimum 95%, Missing); thyroid gland: 86.2069% (minimum 95%, Missing); tongue: 87.7193% (minimum 97%, Missing); urinary bladder: 77.5194% (minimum 97%, Missing)",-0.480516,-0.535217,-0.460899,0,0,routine_complete,8.9,13,11.3,"parathyroid gland: 13 nTPM (protected, limit 2); thymus: 11.3 nTPM (manageable, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); retina: 5.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000000460,FIRRM,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 52.9101% (minimum 75%, Missing); lymph node: 61.7284% (minimum 70%, Missing); parathyroid gland: 43.4783% (minimum 70%, Missing); retina: 65.3595% (minimum 75%, Missing); thymus: 46.9484% (minimum 65%, Missing)",-0.180516,-0.265217,-0.220899,0,0,routine_complete,8.9,13,11.3,"parathyroid gland: 13 nTPM (protected, limit 2); thymus: 11.3 nTPM (manageable, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); retina: 5.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000000460,FIRRM,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 52.9101% (minimum 75%, Missing); lymph node: 61.7284% (minimum 70%, Missing); parathyroid gland: 43.4783% (minimum 70%, Missing); retina: 65.3595% (minimum 75%, Missing); thymus: 46.9484% (minimum 65%, Missing)",-0.180516,-0.265217,-0.220899,0,0,routine_complete,8.9,13,11.3,"parathyroid gland: 13 nTPM (protected, limit 3); thymus: 11.3 nTPM (manageable, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); retina: 5.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); cerebellum: 3 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000000460,FIRRM,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 52.9101% (minimum 75%, Missing); lymph node: 61.7284% (minimum 70%, Missing); parathyroid gland: 43.4783% (minimum 70%, Missing); retina: 65.3595% (minimum 75%, Missing); thymus: 46.9484% (minimum 65%, Missing)",-0.180516,-0.265217,-0.220899,0,0,routine_complete,8.9,13,11.3,"parathyroid gland: 13 nTPM (protected, limit 3); thymus: 11.3 nTPM (manageable, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); retina: 5.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); cerebellum: 3 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000000460,FIRRM,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 52.9101% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.7284% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 43.4783% (minimum 70%, Baseline (adaptation disabled)); retina: 65.3595% (minimum 75%, Baseline (adaptation disabled)); thymus: 46.9484% (minimum 65%, Baseline (adaptation disabled))",-0.180516,-0.265217,-0.220899,0,0,routine_complete,8.9,13,11.3,"parathyroid gland: 13 nTPM (protected, limit 3); thymus: 11.3 nTPM (manageable, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); retina: 5.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); cerebellum: 3 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000000460,FIRRM,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.0000% (minimum 80%, Supported); adrenal gland: 58.8235% (minimum 97%, Supported); amygdala: 68.9655% (minimum 99%, Missing); basal ganglia: 65.9341% (minimum 99%, Missing); bone marrow: 89.5522% (minimum 97%, Supported); cerebellum: 53.5714% (minimum 97%, Supported); cerebral cortex: 63.4921% (minimum 97%, Supported); choroid plexus: 67.0391% (minimum 99%, Missing); colon: 58.5366% (minimum 97%, Missing); duodenum: 66.2983% (minimum 99%, Missing); esophagus: 60.9137% (minimum 90%, Supported); heart muscle: 50.0000% (minimum 97%, Supported); hippocampal formation: 68.5714% (minimum 99%, Missing); hypothalamus: 65.9341% (minimum 99%, Missing); kidney: 56.8720% (minimum 97%, Supported); liver: 59.7015% (minimum 97%, Supported); lung: 65.5738% (minimum 97%, Supported); lymph node: 66.6667% (minimum 90%, Supported); midbrain: 67.7966% (minimum 99%, Missing); pancreas: 60.3015% (minimum 97%, Supported); parathyroid gland: 43.1655% (minimum 90%, Supported); pituitary gland: 56.6038% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 74.5342% (minimum 99%, Missing); salivary gland: 59.7015% (minimum 90%, Supported); skeletal muscle: 49.1803% (minimum 97%, Supported); skin: 66.2983% (minimum 80%, Supported); small intestine: 62.8272% (minimum 99%, Missing); smooth muscle: 61.2245% (minimum 97%, Supported); spinal cord: 65.5738% (minimum 99%, Missing); spleen: 63.8298% (minimum 80%, Supported); stomach: 60.3015% (minimum 90%, Supported); thymus: 52.8634% (minimum 95%, Missing); thyroid gland: 48.7805% (minimum 80%, Supported); tongue: 48.0000% (minimum 97%, Missing); urinary bladder: 58.8235% (minimum 90%, Supported)",-0.421366,-0.49,-0.478197,0,6,partial,12.4,15.8,12.6,"parathyroid gland: 15.8 nTPM (protected, limit 6); tongue: 13 nTPM (protected, limit 2); skeletal muscle: 12.4 nTPM (vital, limit 3); heart muscle: 12 nTPM (vital, limit 3); thymus: 10.7 nTPM (manageable, limit 5); cerebellum: 10.4 nTPM (vital, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 3); colon: 8.5 nTPM (protected, limit 2); adrenal gland: 8.4 nTPM (vital, limit 3); urinary bladder: 8.4 nTPM (protected, limit 6); liver: 8.1 nTPM (vital, limit 3); salivary gland: 8.1 nTPM (protected, limit 6); stomach: 7.9 nTPM (protected, limit 6); pancreas: 7.9 nTPM (vital, limit 3); esophagus: 7.7 nTPM (protected, limit 6); smooth muscle: 7.6 nTPM (vital, limit 3); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); spinal cord: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000001631,KRIT1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.8235% (minimum 65%, Supported); amygdala: 68.9655% (minimum 75%, Missing); basal ganglia: 65.9341% (minimum 75%, Missing); cerebellum: 53.5714% (minimum 65%, Supported); cerebral cortex: 63.4921% (minimum 65%, Supported); choroid plexus: 67.0391% (minimum 75%, Missing); colon: 58.5366% (minimum 70%, Missing); duodenum: 66.2983% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 65%, Supported); hippocampal formation: 68.5714% (minimum 75%, Missing); hypothalamus: 65.9341% (minimum 75%, Missing); kidney: 56.8720% (minimum 65%, Supported); liver: 59.7015% (minimum 65%, Supported); midbrain: 67.7966% (minimum 75%, Missing); pancreas: 60.3015% (minimum 65%, Supported); parathyroid gland: 43.1655% (minimum 60%, Supported); pituitary gland: 56.6038% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 74.5342% (minimum 75%, Missing); salivary gland: 59.7015% (minimum 60%, Supported); skeletal muscle: 49.1803% (minimum 65%, Supported); small intestine: 62.8272% (minimum 75%, Missing); smooth muscle: 61.2245% (minimum 65%, Supported); spinal cord: 65.5738% (minimum 75%, Missing); thymus: 52.8634% (minimum 65%, Missing); thyroid gland: 48.7805% (minimum 55%, Supported); tongue: 48.0000% (minimum 70%, Missing); urinary bladder: 58.8235% (minimum 60%, Supported)",-0.121366,-0.22,-0.183962,0,6,partial,12.4,15.8,12.6,"parathyroid gland: 15.8 nTPM (protected, limit 6); tongue: 13 nTPM (protected, limit 2); skeletal muscle: 12.4 nTPM (vital, limit 3); heart muscle: 12 nTPM (vital, limit 3); thymus: 10.7 nTPM (manageable, limit 5); cerebellum: 10.4 nTPM (vital, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 3); colon: 8.5 nTPM (protected, limit 2); adrenal gland: 8.4 nTPM (vital, limit 3); urinary bladder: 8.4 nTPM (protected, limit 6); liver: 8.1 nTPM (vital, limit 3); salivary gland: 8.1 nTPM (protected, limit 6); stomach: 7.9 nTPM (protected, limit 6); pancreas: 7.9 nTPM (vital, limit 3); esophagus: 7.7 nTPM (protected, limit 6); smooth muscle: 7.6 nTPM (vital, limit 3); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); spinal cord: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000001631,KRIT1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.8235% (minimum 65%, Supported); amygdala: 68.9655% (minimum 75%, Missing); basal ganglia: 65.9341% (minimum 75%, Missing); cerebellum: 53.5714% (minimum 65%, Supported); cerebral cortex: 63.4921% (minimum 65%, Supported); choroid plexus: 67.0391% (minimum 75%, Missing); colon: 58.5366% (minimum 70%, Missing); duodenum: 66.2983% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 65%, Supported); hippocampal formation: 68.5714% (minimum 75%, Missing); hypothalamus: 65.9341% (minimum 75%, Missing); kidney: 56.8720% (minimum 65%, Supported); liver: 59.7015% (minimum 65%, Supported); midbrain: 67.7966% (minimum 75%, Missing); pancreas: 60.3015% (minimum 65%, Supported); parathyroid gland: 43.1655% (minimum 60%, Supported); pituitary gland: 56.6038% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 74.5342% (minimum 75%, Missing); salivary gland: 59.7015% (minimum 60%, Supported); skeletal muscle: 49.1803% (minimum 65%, Supported); small intestine: 62.8272% (minimum 75%, Missing); smooth muscle: 61.2245% (minimum 65%, Supported); spinal cord: 65.5738% (minimum 75%, Missing); thymus: 52.8634% (minimum 65%, Missing); thyroid gland: 48.7805% (minimum 55%, Supported); tongue: 48.0000% (minimum 70%, Missing); urinary bladder: 58.8235% (minimum 60%, Supported)",-0.121366,-0.22,-0.183962,0,6,partial,12.4,15.8,12.6,"parathyroid gland: 15.8 nTPM (protected, limit 6); tongue: 13 nTPM (protected, limit 3); skeletal muscle: 12.4 nTPM (vital, limit 3); heart muscle: 12 nTPM (vital, limit 3); thymus: 10.7 nTPM (manageable, limit 5); cerebellum: 10.4 nTPM (vital, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 3); colon: 8.5 nTPM (protected, limit 3); adrenal gland: 8.4 nTPM (vital, limit 3); urinary bladder: 8.4 nTPM (protected, limit 6); liver: 8.1 nTPM (vital, limit 3); salivary gland: 8.1 nTPM (protected, limit 6); stomach: 7.9 nTPM (protected, limit 6); pancreas: 7.9 nTPM (vital, limit 3); esophagus: 7.7 nTPM (protected, limit 6); smooth muscle: 7.6 nTPM (vital, limit 3); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); spinal cord: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000001631,KRIT1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.8235% (minimum 65%, Supported); amygdala: 68.9655% (minimum 75%, Missing); basal ganglia: 65.9341% (minimum 75%, Missing); cerebellum: 53.5714% (minimum 65%, Supported); cerebral cortex: 63.4921% (minimum 65%, Supported); choroid plexus: 67.0391% (minimum 75%, Missing); colon: 58.5366% (minimum 70%, Missing); duodenum: 66.2983% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 65%, Supported); hippocampal formation: 68.5714% (minimum 75%, Missing); hypothalamus: 65.9341% (minimum 75%, Missing); kidney: 56.8720% (minimum 65%, Supported); liver: 59.7015% (minimum 65%, Supported); midbrain: 67.7966% (minimum 75%, Missing); pancreas: 60.3015% (minimum 65%, Supported); parathyroid gland: 43.1655% (minimum 60%, Supported); pituitary gland: 56.6038% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 74.5342% (minimum 75%, Missing); salivary gland: 59.7015% (minimum 60%, Supported); skeletal muscle: 49.1803% (minimum 65%, Supported); small intestine: 62.8272% (minimum 75%, Missing); smooth muscle: 61.2245% (minimum 65%, Supported); spinal cord: 65.5738% (minimum 75%, Missing); thymus: 52.8634% (minimum 65%, Missing); thyroid gland: 48.7805% (minimum 55%, Supported); tongue: 48.0000% (minimum 70%, Missing); urinary bladder: 58.8235% (minimum 60%, Supported)",-0.121366,-0.22,-0.183962,0,6,partial,12.4,15.8,12.6,"parathyroid gland: 15.8 nTPM (protected, limit 6); tongue: 13 nTPM (protected, limit 3); skeletal muscle: 12.4 nTPM (vital, limit 3); heart muscle: 12 nTPM (vital, limit 3); thymus: 10.7 nTPM (manageable, limit 5); cerebellum: 10.4 nTPM (vital, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 3); colon: 8.5 nTPM (protected, limit 3); adrenal gland: 8.4 nTPM (vital, limit 3); urinary bladder: 8.4 nTPM (protected, limit 6); liver: 8.1 nTPM (vital, limit 3); salivary gland: 8.1 nTPM (protected, limit 6); stomach: 7.9 nTPM (protected, limit 6); pancreas: 7.9 nTPM (vital, limit 3); esophagus: 7.7 nTPM (protected, limit 6); smooth muscle: 7.6 nTPM (vital, limit 3); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); spinal cord: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000001631,KRIT1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 58.8235% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.9655% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.9341% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 53.5714% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.4921% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.0391% (minimum 75%, Baseline (adaptation disabled)); colon: 58.5366% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.2983% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.9137% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.5714% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.9341% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.8720% (minimum 75%, Baseline (adaptation disabled)); liver: 59.7015% (minimum 75%, Baseline (adaptation disabled)); lung: 65.5738% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); midbrain: 67.7966% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.3015% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 43.1655% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 56.6038% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 74.5342% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.7015% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 49.1803% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.8272% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.2245% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.5738% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.8298% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.3015% (minimum 70%, Baseline (adaptation disabled)); thymus: 52.8634% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 48.7805% (minimum 65%, Baseline (adaptation disabled)); tongue: 48.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.8235% (minimum 70%, Baseline (adaptation disabled))",-0.162195,-0.268345,-0.258197,0,6,partial,12.4,15.8,12.6,"parathyroid gland: 15.8 nTPM (protected, limit 3); tongue: 13 nTPM (protected, limit 3); thyroid gland: 12.6 nTPM (manageable, limit 5); skeletal muscle: 12.4 nTPM (vital, limit 1); heart muscle: 12 nTPM (vital, limit 1); thymus: 10.7 nTPM (manageable, limit 5); cerebellum: 10.4 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 3); urinary bladder: 8.4 nTPM (protected, limit 3); adrenal gland: 8.4 nTPM (vital, limit 1); salivary gland: 8.1 nTPM (protected, limit 3); liver: 8.1 nTPM (vital, limit 1); adipose tissue: 8 nTPM (manageable, limit 5); stomach: 7.9 nTPM (protected, limit 3); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 3); smooth muscle: 7.6 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); lung: 6.3 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); lymph node: 6 nTPM (protected, limit 3); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000001631,KRIT1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 50.7317% (minimum 99%, Missing); lung: 98.5782% (minimum 99%, Missing); parathyroid gland: 84.8980% (minimum 97%, Missing); smooth muscle: 92.4444% (minimum 99%, Uncertain); thymus: 94.5455% (minimum 95%, Missing)",-0.00454545,-0.12102,-0.482683,0,1,partial,20.2,3.7,1.2,"bone marrow: 20.2 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000004809,SLC22A16,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 50.7317% (minimum 75%, Missing)",0.295455,0.14898,-0.242683,0,1,partial,20.2,3.7,1.2,"bone marrow: 20.2 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000004809,SLC22A16,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 50.7317% (minimum 75%, Missing)",0.295455,0.14898,-0.242683,0,1,partial,20.2,3.7,1.2,"bone marrow: 20.2 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000004809,SLC22A16,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 50.7317% (minimum 75%, Missing)",0.295455,0.14898,-0.242683,0,1,partial,20.2,3.7,1.2,"bone marrow: 20.2 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000004809,SLC22A16,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 50.7317% (minimum 75%, Baseline (adaptation disabled))",0.295455,0.14898,-0.242683,0,1,partial,20.2,3.7,1.2,"bone marrow: 20.2 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000004809,SLC22A16,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7441% (minimum 99%, Missing); basal ganglia: 95.3338% (minimum 99%, Missing); choroid plexus: 75.2846% (minimum 99%, Missing); hippocampal formation: 96.8401% (minimum 99%, Missing); hypothalamus: 95.8794% (minimum 99%, Missing); lung: 95.8794% (minimum 99%, Missing); pituitary gland: 97.7441% (minimum 99%, Missing); retina: 98.7814% (minimum 99%, Missing)",0.0428882,0.0158768,-0.237154,0,80,unavailable,82.5,3.6,1.8,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000004838,ZMYND10,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342888,0.285877,0.00284602,0,80,unavailable,82.5,3.6,1.8,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000004838,ZMYND10,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342888,0.285877,0.00284602,0,80,unavailable,82.5,3.6,1.8,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000004838,ZMYND10,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342888,0.285877,0.00284602,0,80,unavailable,82.5,3.6,1.8,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000004838,ZMYND10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342888,0.285877,0.00284602,0,80,unavailable,82.5,3.6,1.8,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000004838,ZMYND10,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.7736% (minimum 95%, Missing); adrenal gland: 62.1324% (minimum 99%, Missing); amygdala: 72.2222% (minimum 99%, Missing); basal ganglia: 71.9149% (minimum 99%, Missing); bone marrow: 57.2881% (minimum 99%, Missing); cerebellum: 65.5039% (minimum 99%, Missing); cerebral cortex: 58.0756% (minimum 99%, Missing); choroid plexus: 66.0156% (minimum 99%, Missing); colon: 58.2759% (minimum 97%, Missing); duodenum: 55.7756% (minimum 99%, Missing); esophagus: 56.3333% (minimum 97%, Missing); heart muscle: 52.0000% (minimum 99%, Missing); hippocampal formation: 73.1602% (minimum 99%, Missing); hypothalamus: 66.5354% (minimum 99%, Missing); kidney: 57.4830% (minimum 99%, Missing); liver: 52.9781% (minimum 99%, Missing); lung: 63.0597% (minimum 99%, Missing); lymph node: 36.8996% (minimum 97%, Missing); midbrain: 71.9149% (minimum 99%, Missing); pancreas: 67.0635% (minimum 99%, Missing); parathyroid gland: 50.2976% (minimum 97%, Missing); pituitary gland: 67.8715% (minimum 99%, Missing); rectum: 57.6792% (minimum 97%, Missing); retina: 61.0108% (minimum 99%, Missing); salivary gland: 64.0152% (minimum 97%, Missing); skeletal muscle: 43.4447% (minimum 99%, Missing); skin: 60.7914% (minimum 95%, Missing); small intestine: 57.8767% (minimum 99%, Missing); smooth muscle: 53.3123% (minimum 99%, Missing); spinal cord: 68.6992% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 61.0108% (minimum 97%, Missing); thymus: 42.4623% (minimum 95%, Missing); thyroid gland: 55.7756% (minimum 95%, Missing); tongue: 42.6768% (minimum 97%, Missing); urinary bladder: 50.9036% (minimum 97%, Missing)",-0.525377,-0.601004,-0.555553,0,3,partial,22,28.9,22.9,"lymph node: 28.9 nTPM (protected, limit 2); thymus: 22.9 nTPM (manageable, limit 5); tongue: 22.7 nTPM (protected, limit 2); skeletal muscle: 22 nTPM (vital, limit 1); spleen: 16.9 nTPM (manageable, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 2); urinary bladder: 16.3 nTPM (protected, limit 2); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 2); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); skin: 10.9 nTPM (manageable, limit 5); stomach: 10.8 nTPM (protected, limit 2); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 2); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005175,RPAP3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.7736% (minimum 65%, Missing); adrenal gland: 62.1324% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 71.9149% (minimum 75%, Missing); bone marrow: 57.2881% (minimum 75%, Missing); cerebellum: 65.5039% (minimum 75%, Missing); cerebral cortex: 58.0756% (minimum 75%, Missing); choroid plexus: 66.0156% (minimum 75%, Missing); colon: 58.2759% (minimum 70%, Missing); duodenum: 55.7756% (minimum 75%, Missing); esophagus: 56.3333% (minimum 70%, Missing); heart muscle: 52.0000% (minimum 75%, Missing); hippocampal formation: 73.1602% (minimum 75%, Missing); hypothalamus: 66.5354% (minimum 75%, Missing); kidney: 57.4830% (minimum 75%, Missing); liver: 52.9781% (minimum 75%, Missing); lung: 63.0597% (minimum 75%, Missing); lymph node: 36.8996% (minimum 70%, Missing); midbrain: 71.9149% (minimum 75%, Missing); pancreas: 67.0635% (minimum 75%, Missing); parathyroid gland: 50.2976% (minimum 70%, Missing); pituitary gland: 67.8715% (minimum 75%, Missing); rectum: 57.6792% (minimum 70%, Missing); retina: 61.0108% (minimum 75%, Missing); salivary gland: 64.0152% (minimum 70%, Missing); skeletal muscle: 43.4447% (minimum 75%, Missing); skin: 60.7914% (minimum 65%, Missing); small intestine: 57.8767% (minimum 75%, Missing); smooth muscle: 53.3123% (minimum 75%, Missing); spinal cord: 68.6992% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 61.0108% (minimum 70%, Missing); thymus: 42.4623% (minimum 65%, Missing); thyroid gland: 55.7756% (minimum 65%, Missing); tongue: 42.6768% (minimum 70%, Missing); urinary bladder: 50.9036% (minimum 70%, Missing)",-0.225377,-0.331004,-0.315553,0,3,partial,22,28.9,22.9,"lymph node: 28.9 nTPM (protected, limit 2); thymus: 22.9 nTPM (manageable, limit 5); tongue: 22.7 nTPM (protected, limit 2); skeletal muscle: 22 nTPM (vital, limit 1); spleen: 16.9 nTPM (manageable, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 2); urinary bladder: 16.3 nTPM (protected, limit 2); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 2); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); skin: 10.9 nTPM (manageable, limit 5); stomach: 10.8 nTPM (protected, limit 2); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 2); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005175,RPAP3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.7736% (minimum 65%, Missing); adrenal gland: 62.1324% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 71.9149% (minimum 75%, Missing); bone marrow: 57.2881% (minimum 75%, Missing); cerebellum: 65.5039% (minimum 75%, Missing); cerebral cortex: 58.0756% (minimum 75%, Missing); choroid plexus: 66.0156% (minimum 75%, Missing); colon: 58.2759% (minimum 70%, Missing); duodenum: 55.7756% (minimum 75%, Missing); esophagus: 56.3333% (minimum 70%, Missing); heart muscle: 52.0000% (minimum 75%, Missing); hippocampal formation: 73.1602% (minimum 75%, Missing); hypothalamus: 66.5354% (minimum 75%, Missing); kidney: 57.4830% (minimum 75%, Missing); liver: 52.9781% (minimum 75%, Missing); lung: 63.0597% (minimum 75%, Missing); lymph node: 36.8996% (minimum 70%, Missing); midbrain: 71.9149% (minimum 75%, Missing); pancreas: 67.0635% (minimum 75%, Missing); parathyroid gland: 50.2976% (minimum 70%, Missing); pituitary gland: 67.8715% (minimum 75%, Missing); rectum: 57.6792% (minimum 70%, Missing); retina: 61.0108% (minimum 75%, Missing); salivary gland: 64.0152% (minimum 70%, Missing); skeletal muscle: 43.4447% (minimum 75%, Missing); skin: 60.7914% (minimum 65%, Missing); small intestine: 57.8767% (minimum 75%, Missing); smooth muscle: 53.3123% (minimum 75%, Missing); spinal cord: 68.6992% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 61.0108% (minimum 70%, Missing); thymus: 42.4623% (minimum 65%, Missing); thyroid gland: 55.7756% (minimum 65%, Missing); tongue: 42.6768% (minimum 70%, Missing); urinary bladder: 50.9036% (minimum 70%, Missing)",-0.225377,-0.331004,-0.315553,0,3,partial,22,28.9,22.9,"lymph node: 28.9 nTPM (protected, limit 3); thymus: 22.9 nTPM (manageable, limit 5); tongue: 22.7 nTPM (protected, limit 3); skeletal muscle: 22 nTPM (vital, limit 1); spleen: 16.9 nTPM (manageable, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 3); urinary bladder: 16.3 nTPM (protected, limit 3); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 3); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 3); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 3); skin: 10.9 nTPM (manageable, limit 5); stomach: 10.8 nTPM (protected, limit 3); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 3); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005175,RPAP3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.7736% (minimum 65%, Missing); adrenal gland: 62.1324% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 71.9149% (minimum 75%, Missing); bone marrow: 57.2881% (minimum 75%, Missing); cerebellum: 65.5039% (minimum 75%, Missing); cerebral cortex: 58.0756% (minimum 75%, Missing); choroid plexus: 66.0156% (minimum 75%, Missing); colon: 58.2759% (minimum 70%, Missing); duodenum: 55.7756% (minimum 75%, Missing); esophagus: 56.3333% (minimum 70%, Missing); heart muscle: 52.0000% (minimum 75%, Missing); hippocampal formation: 73.1602% (minimum 75%, Missing); hypothalamus: 66.5354% (minimum 75%, Missing); kidney: 57.4830% (minimum 75%, Missing); liver: 52.9781% (minimum 75%, Missing); lung: 63.0597% (minimum 75%, Missing); lymph node: 36.8996% (minimum 70%, Missing); midbrain: 71.9149% (minimum 75%, Missing); pancreas: 67.0635% (minimum 75%, Missing); parathyroid gland: 50.2976% (minimum 70%, Missing); pituitary gland: 67.8715% (minimum 75%, Missing); rectum: 57.6792% (minimum 70%, Missing); retina: 61.0108% (minimum 75%, Missing); salivary gland: 64.0152% (minimum 70%, Missing); skeletal muscle: 43.4447% (minimum 75%, Missing); skin: 60.7914% (minimum 65%, Missing); small intestine: 57.8767% (minimum 75%, Missing); smooth muscle: 53.3123% (minimum 75%, Missing); spinal cord: 68.6992% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 61.0108% (minimum 70%, Missing); thymus: 42.4623% (minimum 65%, Missing); thyroid gland: 55.7756% (minimum 65%, Missing); tongue: 42.6768% (minimum 70%, Missing); urinary bladder: 50.9036% (minimum 70%, Missing)",-0.225377,-0.331004,-0.315553,0,3,partial,22,28.9,22.9,"lymph node: 28.9 nTPM (protected, limit 3); thymus: 22.9 nTPM (manageable, limit 5); tongue: 22.7 nTPM (protected, limit 3); skeletal muscle: 22 nTPM (vital, limit 1); spleen: 16.9 nTPM (manageable, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 3); urinary bladder: 16.3 nTPM (protected, limit 3); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 3); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 3); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 3); skin: 10.9 nTPM (manageable, limit 5); stomach: 10.8 nTPM (protected, limit 3); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 3); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005175,RPAP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.7736% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.1324% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.2222% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.9149% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 57.2881% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.5039% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.0756% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.0156% (minimum 75%, Baseline (adaptation disabled)); colon: 58.2759% (minimum 70%, Baseline (adaptation disabled)); duodenum: 55.7756% (minimum 75%, Baseline (adaptation disabled)); esophagus: 56.3333% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.1602% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.5354% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.4830% (minimum 75%, Baseline (adaptation disabled)); liver: 52.9781% (minimum 75%, Baseline (adaptation disabled)); lung: 63.0597% (minimum 75%, Baseline (adaptation disabled)); lymph node: 36.8996% (minimum 70%, Baseline (adaptation disabled)); midbrain: 71.9149% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.0635% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.2976% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.8715% (minimum 75%, Baseline (adaptation disabled)); rectum: 57.6792% (minimum 70%, Baseline (adaptation disabled)); retina: 61.0108% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.0152% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 43.4447% (minimum 75%, Baseline (adaptation disabled)); skin: 60.7914% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.8767% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.3123% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.6992% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.0108% (minimum 70%, Baseline (adaptation disabled)); thymus: 42.4623% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.7756% (minimum 65%, Baseline (adaptation disabled)); tongue: 42.6768% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 50.9036% (minimum 70%, Baseline (adaptation disabled))",-0.225377,-0.331004,-0.315553,0,3,partial,22,28.9,22.9,"lymph node: 28.9 nTPM (protected, limit 3); thymus: 22.9 nTPM (manageable, limit 5); tongue: 22.7 nTPM (protected, limit 3); skeletal muscle: 22 nTPM (vital, limit 1); spleen: 16.9 nTPM (manageable, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 3); urinary bladder: 16.3 nTPM (protected, limit 3); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 3); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 3); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 3); skin: 10.9 nTPM (manageable, limit 5); stomach: 10.8 nTPM (protected, limit 3); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 3); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005175,RPAP3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 96.6985% (minimum 98%, Approved); parathyroid gland: 89.6376% (minimum 95%, Approved); retina: 98.7870% (minimum 99%, Missing)",0.0288918,-0.0536242,-0.0130148,0,2,partial,11.4,38.6,7.2,"parathyroid gland: 38.6 nTPM (protected, limit 4); bone marrow: 11.4 nTPM (vital, limit 2); thymus: 7.2 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 2); rectum: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 2); cerebellum: 2.5 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005189,REXO5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.328892,0.246376,0.23787,0,2,partial,11.4,38.6,7.2,"parathyroid gland: 38.6 nTPM (protected, limit 4); bone marrow: 11.4 nTPM (vital, limit 2); thymus: 7.2 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 2); rectum: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 2); cerebellum: 2.5 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005189,REXO5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.328892,0.246376,0.23787,0,2,partial,11.4,38.6,7.2,"parathyroid gland: 38.6 nTPM (protected, limit 4); bone marrow: 11.4 nTPM (vital, limit 2); thymus: 7.2 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 2); smooth muscle: 2.6 nTPM (vital, limit 2); cerebellum: 2.5 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005189,REXO5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.328892,0.246376,0.23787,0,2,partial,11.4,38.6,7.2,"parathyroid gland: 38.6 nTPM (protected, limit 4); bone marrow: 11.4 nTPM (vital, limit 2); thymus: 7.2 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 2); smooth muscle: 2.6 nTPM (vital, limit 2); cerebellum: 2.5 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005189,REXO5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.328892,0.196376,0.216985,0,2,partial,11.4,38.6,7.2,"parathyroid gland: 38.6 nTPM (protected, limit 3); bone marrow: 11.4 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005189,REXO5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 54.3165% (minimum 95%, Missing); adrenal gland: 69.5853% (minimum 99%, Missing); amygdala: 75.8794% (minimum 99%, Missing); basal ganglia: 76.2626% (minimum 99%, Missing); bone marrow: 34.0858% (minimum 99%, Missing); cerebellum: 68.6364% (minimum 99%, Missing); cerebral cortex: 69.2661% (minimum 99%, Missing); choroid plexus: 80.7487% (minimum 99%, Missing); colon: 61.3821% (minimum 97%, Missing); duodenum: 69.5853% (minimum 99%, Missing); esophagus: 68.6364% (minimum 97%, Missing); heart muscle: 63.9831% (minimum 99%, Missing); hippocampal formation: 76.2626% (minimum 99%, Missing); hypothalamus: 78.2383% (minimum 99%, Missing); kidney: 66.2281% (minimum 99%, Missing); liver: 60.6426% (minimum 99%, Missing); lung: 64.5299% (minimum 99%, Missing); lymph node: 57.1970% (minimum 97%, Missing); midbrain: 75.8794% (minimum 99%, Missing); pancreas: 61.1336% (minimum 99%, Missing); parathyroid gland: 50.3333% (minimum 97%, Missing); pituitary gland: 71.9048% (minimum 99%, Missing); rectum: 71.9048% (minimum 97%, Missing); retina: 60.4000% (minimum 99%, Missing); salivary gland: 67.7130% (minimum 97%, Missing); skeletal muscle: 50.8418% (minimum 99%, Missing); skin: 65.9389% (minimum 95%, Missing); small intestine: 65.6522% (minimum 99%, Missing); smooth muscle: 51.8900% (minimum 99%, Missing); spinal cord: 73.6585% (minimum 99%, Missing); spleen: 55.7196% (minimum 95%, Missing); stomach: 66.2281% (minimum 97%, Missing); thymus: 47.3354% (minimum 95%, Missing); thyroid gland: 59.2157% (minimum 95%, Missing); tongue: 55.7196% (minimum 97%, Missing); urinary bladder: 63.1799% (minimum 97%, Missing)",-0.476646,-0.466667,-0.649142,0,4,partial,29.2,14.9,16.8,"bone marrow: 29.2 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); parathyroid gland: 14.9 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); tongue: 12 nTPM (protected, limit 2); spleen: 12 nTPM (manageable, limit 5); lymph node: 11.3 nTPM (protected, limit 2); thyroid gland: 10.4 nTPM (manageable, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); urinary bladder: 8.8 nTPM (protected, limit 2); heart muscle: 8.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); cerebral cortex: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005889,ZFX,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 54.3165% (minimum 65%, Missing); adrenal gland: 69.5853% (minimum 75%, Missing); bone marrow: 34.0858% (minimum 75%, Missing); cerebellum: 68.6364% (minimum 75%, Missing); cerebral cortex: 69.2661% (minimum 75%, Missing); colon: 61.3821% (minimum 70%, Missing); duodenum: 69.5853% (minimum 75%, Missing); esophagus: 68.6364% (minimum 70%, Missing); heart muscle: 63.9831% (minimum 75%, Missing); kidney: 66.2281% (minimum 75%, Missing); liver: 60.6426% (minimum 75%, Missing); lung: 64.5299% (minimum 75%, Missing); lymph node: 57.1970% (minimum 70%, Missing); pancreas: 61.1336% (minimum 75%, Missing); parathyroid gland: 50.3333% (minimum 70%, Missing); pituitary gland: 71.9048% (minimum 75%, Missing); retina: 60.4000% (minimum 75%, Missing); salivary gland: 67.7130% (minimum 70%, Missing); skeletal muscle: 50.8418% (minimum 75%, Missing); small intestine: 65.6522% (minimum 75%, Missing); smooth muscle: 51.8900% (minimum 75%, Missing); spinal cord: 73.6585% (minimum 75%, Missing); spleen: 55.7196% (minimum 65%, Missing); stomach: 66.2281% (minimum 70%, Missing); thymus: 47.3354% (minimum 65%, Missing); thyroid gland: 59.2157% (minimum 65%, Missing); tongue: 55.7196% (minimum 70%, Missing); urinary bladder: 63.1799% (minimum 70%, Missing)",-0.176646,-0.196667,-0.409142,0,4,partial,29.2,14.9,16.8,"bone marrow: 29.2 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); parathyroid gland: 14.9 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); tongue: 12 nTPM (protected, limit 2); spleen: 12 nTPM (manageable, limit 5); lymph node: 11.3 nTPM (protected, limit 2); thyroid gland: 10.4 nTPM (manageable, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); urinary bladder: 8.8 nTPM (protected, limit 2); heart muscle: 8.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); cerebral cortex: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005889,ZFX,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 54.3165% (minimum 65%, Missing); adrenal gland: 69.5853% (minimum 75%, Missing); bone marrow: 34.0858% (minimum 75%, Missing); cerebellum: 68.6364% (minimum 75%, Missing); cerebral cortex: 69.2661% (minimum 75%, Missing); colon: 61.3821% (minimum 70%, Missing); duodenum: 69.5853% (minimum 75%, Missing); esophagus: 68.6364% (minimum 70%, Missing); heart muscle: 63.9831% (minimum 75%, Missing); kidney: 66.2281% (minimum 75%, Missing); liver: 60.6426% (minimum 75%, Missing); lung: 64.5299% (minimum 75%, Missing); lymph node: 57.1970% (minimum 70%, Missing); pancreas: 61.1336% (minimum 75%, Missing); parathyroid gland: 50.3333% (minimum 70%, Missing); pituitary gland: 71.9048% (minimum 75%, Missing); retina: 60.4000% (minimum 75%, Missing); salivary gland: 67.7130% (minimum 70%, Missing); skeletal muscle: 50.8418% (minimum 75%, Missing); small intestine: 65.6522% (minimum 75%, Missing); smooth muscle: 51.8900% (minimum 75%, Missing); spinal cord: 73.6585% (minimum 75%, Missing); spleen: 55.7196% (minimum 65%, Missing); stomach: 66.2281% (minimum 70%, Missing); thymus: 47.3354% (minimum 65%, Missing); thyroid gland: 59.2157% (minimum 65%, Missing); tongue: 55.7196% (minimum 70%, Missing); urinary bladder: 63.1799% (minimum 70%, Missing)",-0.176646,-0.196667,-0.409142,0,4,partial,29.2,14.9,16.8,"bone marrow: 29.2 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); parathyroid gland: 14.9 nTPM (protected, limit 3); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); tongue: 12 nTPM (protected, limit 3); spleen: 12 nTPM (manageable, limit 5); lymph node: 11.3 nTPM (protected, limit 3); thyroid gland: 10.4 nTPM (manageable, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 3); urinary bladder: 8.8 nTPM (protected, limit 3); heart muscle: 8.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); cerebral cortex: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005889,ZFX,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 54.3165% (minimum 65%, Missing); adrenal gland: 69.5853% (minimum 75%, Missing); bone marrow: 34.0858% (minimum 75%, Missing); cerebellum: 68.6364% (minimum 75%, Missing); cerebral cortex: 69.2661% (minimum 75%, Missing); colon: 61.3821% (minimum 70%, Missing); duodenum: 69.5853% (minimum 75%, Missing); esophagus: 68.6364% (minimum 70%, Missing); heart muscle: 63.9831% (minimum 75%, Missing); kidney: 66.2281% (minimum 75%, Missing); liver: 60.6426% (minimum 75%, Missing); lung: 64.5299% (minimum 75%, Missing); lymph node: 57.1970% (minimum 70%, Missing); pancreas: 61.1336% (minimum 75%, Missing); parathyroid gland: 50.3333% (minimum 70%, Missing); pituitary gland: 71.9048% (minimum 75%, Missing); retina: 60.4000% (minimum 75%, Missing); salivary gland: 67.7130% (minimum 70%, Missing); skeletal muscle: 50.8418% (minimum 75%, Missing); small intestine: 65.6522% (minimum 75%, Missing); smooth muscle: 51.8900% (minimum 75%, Missing); spinal cord: 73.6585% (minimum 75%, Missing); spleen: 55.7196% (minimum 65%, Missing); stomach: 66.2281% (minimum 70%, Missing); thymus: 47.3354% (minimum 65%, Missing); thyroid gland: 59.2157% (minimum 65%, Missing); tongue: 55.7196% (minimum 70%, Missing); urinary bladder: 63.1799% (minimum 70%, Missing)",-0.176646,-0.196667,-0.409142,0,4,partial,29.2,14.9,16.8,"bone marrow: 29.2 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); parathyroid gland: 14.9 nTPM (protected, limit 3); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); tongue: 12 nTPM (protected, limit 3); spleen: 12 nTPM (manageable, limit 5); lymph node: 11.3 nTPM (protected, limit 3); thyroid gland: 10.4 nTPM (manageable, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 3); urinary bladder: 8.8 nTPM (protected, limit 3); heart muscle: 8.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); cerebral cortex: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005889,ZFX,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 54.3165% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 69.5853% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 34.0858% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.6364% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 69.2661% (minimum 75%, Baseline (adaptation disabled)); colon: 61.3821% (minimum 70%, Baseline (adaptation disabled)); duodenum: 69.5853% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.6364% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.9831% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.2281% (minimum 75%, Baseline (adaptation disabled)); liver: 60.6426% (minimum 75%, Baseline (adaptation disabled)); lung: 64.5299% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.1970% (minimum 70%, Baseline (adaptation disabled)); pancreas: 61.1336% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.3333% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.9048% (minimum 75%, Baseline (adaptation disabled)); retina: 60.4000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 67.7130% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 50.8418% (minimum 75%, Baseline (adaptation disabled)); small intestine: 65.6522% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 51.8900% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.6585% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.7196% (minimum 65%, Baseline (adaptation disabled)); stomach: 66.2281% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.3354% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 59.2157% (minimum 65%, Baseline (adaptation disabled)); tongue: 55.7196% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.1799% (minimum 70%, Baseline (adaptation disabled))",-0.176646,-0.196667,-0.409142,0,4,partial,29.2,14.9,16.8,"bone marrow: 29.2 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); parathyroid gland: 14.9 nTPM (protected, limit 3); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); tongue: 12 nTPM (protected, limit 3); spleen: 12 nTPM (manageable, limit 5); lymph node: 11.3 nTPM (protected, limit 3); thyroid gland: 10.4 nTPM (manageable, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 3); urinary bladder: 8.8 nTPM (protected, limit 3); heart muscle: 8.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); cerebral cortex: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000005889,ZFX,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.05,0.0298134,0.00646643,0,1,partial,3.9,7,2.9,"hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006047,YBX2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.299813,0.246466,0,1,partial,3.9,7,2.9,"hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006047,YBX2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.299813,0.246466,0,1,partial,3.9,7,2.9,"hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006047,YBX2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.299813,0.246466,0,1,partial,3.9,7,2.9,"hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006047,YBX2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344617,0.287104,0.242774,0,1,partial,3.9,7,2.9,"colon: 7 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006047,YBX2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 80%, Supported); esophagus: 72.7273% (minimum 90%, Supported); salivary gland: 82.7586% (minimum 90%, Supported); skin: 4.9587% (minimum 95%, Missing)",-0.900413,-0.172727,0.01,0,6,partial,0,0.9,46,"skin: 46 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006059,KRT33A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.9587% (minimum 65%, Missing)",-0.600413,0.127273,0.25,0,6,partial,0,0.9,46,"skin: 46 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006059,KRT33A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.9587% (minimum 65%, Missing)",-0.600413,0.127273,0.25,0,6,partial,0,0.9,46,"skin: 46 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006059,KRT33A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.9587% (minimum 65%, Missing)",-0.600413,0.127273,0.25,0,6,partial,0,0.9,46,"skin: 46 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006059,KRT33A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.9587% (minimum 65%, Baseline (adaptation disabled))",-0.600413,0.0272727,0.25,0,6,partial,0,0.9,46,"skin: 46 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006059,KRT33A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3548% (minimum 95%, Missing); adrenal gland: 81.4159% (minimum 99%, Missing); amygdala: 88.4615% (minimum 99%, Missing); basal ganglia: 88.4615% (minimum 99%, Missing); bone marrow: 36.2205% (minimum 99%, Missing); cerebellum: 77.9661% (minimum 99%, Missing); cerebral cortex: 73.0159% (minimum 99%, Missing); choroid plexus: 92.9293% (minimum 99%, Missing); colon: 53.1792% (minimum 97%, Missing); duodenum: 53.4884% (minimum 99%, Missing); esophagus: 57.8616% (minimum 97%, Missing); heart muscle: 70.2290% (minimum 99%, Uncertain); hippocampal formation: 86.7925% (minimum 99%, Missing); hypothalamus: 89.3204% (minimum 99%, Missing); kidney: 72.4409% (minimum 99%, Missing); liver: 58.5987% (minimum 99%, Missing); lung: 66.6667% (minimum 99%, Missing); lymph node: 57.5000% (minimum 97%, Missing); midbrain: 87.6190% (minimum 99%, Missing); pancreas: 67.6471% (minimum 99%, Missing); parathyroid gland: 69.6970% (minimum 97%, Missing); pituitary gland: 88.4615% (minimum 99%, Missing); rectum: 50.5495% (minimum 97%, Missing); retina: 61.7450% (minimum 99%, Missing); salivary gland: 65.2482% (minimum 97%, Missing); skeletal muscle: 42.9907% (minimum 99%, Missing); skin: 55.7576% (minimum 95%, Missing); small intestine: 53.1792% (minimum 99%, Missing); smooth muscle: 68.6567% (minimum 99%, Missing); spinal cord: 82.1429% (minimum 99%, Missing); spleen: 63.0137% (minimum 95%, Missing); stomach: 50.2732% (minimum 97%, Missing); thymus: 58.5987% (minimum 95%, Missing); thyroid gland: 77.3109% (minimum 95%, Missing); tongue: 42.0091% (minimum 97%, Missing); urinary bladder: 62.5850% (minimum 97%, Missing)",-0.392424,-0.549909,-0.627795,0,1,partial,16.2,12.7,7.3,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); rectum: 9 nTPM (protected, limit 2); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 2); duodenum: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 2); esophagus: 6.7 nTPM (protected, limit 2); thymus: 6.5 nTPM (manageable, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 4.9 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006459,KDM7A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3548% (minimum 65%, Missing); bone marrow: 36.2205% (minimum 75%, Missing); cerebral cortex: 73.0159% (minimum 75%, Missing); colon: 53.1792% (minimum 70%, Missing); duodenum: 53.4884% (minimum 75%, Missing); esophagus: 57.8616% (minimum 70%, Missing); heart muscle: 70.2290% (minimum 75%, Uncertain); kidney: 72.4409% (minimum 75%, Missing); liver: 58.5987% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); lymph node: 57.5000% (minimum 70%, Missing); pancreas: 67.6471% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); rectum: 50.5495% (minimum 70%, Missing); retina: 61.7450% (minimum 75%, Missing); salivary gland: 65.2482% (minimum 70%, Missing); skeletal muscle: 42.9907% (minimum 75%, Missing); skin: 55.7576% (minimum 65%, Missing); small intestine: 53.1792% (minimum 75%, Missing); smooth muscle: 68.6567% (minimum 75%, Missing); spleen: 63.0137% (minimum 65%, Missing); stomach: 50.2732% (minimum 70%, Missing); thymus: 58.5987% (minimum 65%, Missing); tongue: 42.0091% (minimum 70%, Missing); urinary bladder: 62.5850% (minimum 70%, Missing)",-0.0924242,-0.279909,-0.387795,0,1,partial,16.2,12.7,7.3,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); rectum: 9 nTPM (protected, limit 2); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 2); duodenum: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 2); esophagus: 6.7 nTPM (protected, limit 2); thymus: 6.5 nTPM (manageable, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 4.9 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006459,KDM7A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3548% (minimum 65%, Missing); bone marrow: 36.2205% (minimum 75%, Missing); cerebral cortex: 73.0159% (minimum 75%, Missing); colon: 53.1792% (minimum 70%, Missing); duodenum: 53.4884% (minimum 75%, Missing); esophagus: 57.8616% (minimum 70%, Missing); heart muscle: 70.2290% (minimum 75%, Uncertain); kidney: 72.4409% (minimum 75%, Missing); liver: 58.5987% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); lymph node: 57.5000% (minimum 70%, Missing); pancreas: 67.6471% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); rectum: 50.5495% (minimum 70%, Missing); retina: 61.7450% (minimum 75%, Missing); salivary gland: 65.2482% (minimum 70%, Missing); skeletal muscle: 42.9907% (minimum 75%, Missing); skin: 55.7576% (minimum 65%, Missing); small intestine: 53.1792% (minimum 75%, Missing); smooth muscle: 68.6567% (minimum 75%, Missing); spleen: 63.0137% (minimum 65%, Missing); stomach: 50.2732% (minimum 70%, Missing); thymus: 58.5987% (minimum 65%, Missing); tongue: 42.0091% (minimum 70%, Missing); urinary bladder: 62.5850% (minimum 70%, Missing)",-0.0924242,-0.279909,-0.387795,0,1,partial,16.2,12.7,7.3,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); rectum: 9 nTPM (protected, limit 3); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 3); duodenum: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 3); esophagus: 6.7 nTPM (protected, limit 3); thymus: 6.5 nTPM (manageable, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 4.9 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006459,KDM7A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3548% (minimum 65%, Missing); bone marrow: 36.2205% (minimum 75%, Missing); cerebral cortex: 73.0159% (minimum 75%, Missing); colon: 53.1792% (minimum 70%, Missing); duodenum: 53.4884% (minimum 75%, Missing); esophagus: 57.8616% (minimum 70%, Missing); heart muscle: 70.2290% (minimum 75%, Uncertain); kidney: 72.4409% (minimum 75%, Missing); liver: 58.5987% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); lymph node: 57.5000% (minimum 70%, Missing); pancreas: 67.6471% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); rectum: 50.5495% (minimum 70%, Missing); retina: 61.7450% (minimum 75%, Missing); salivary gland: 65.2482% (minimum 70%, Missing); skeletal muscle: 42.9907% (minimum 75%, Missing); skin: 55.7576% (minimum 65%, Missing); small intestine: 53.1792% (minimum 75%, Missing); smooth muscle: 68.6567% (minimum 75%, Missing); spleen: 63.0137% (minimum 65%, Missing); stomach: 50.2732% (minimum 70%, Missing); thymus: 58.5987% (minimum 65%, Missing); tongue: 42.0091% (minimum 70%, Missing); urinary bladder: 62.5850% (minimum 70%, Missing)",-0.0924242,-0.279909,-0.387795,0,1,partial,16.2,12.7,7.3,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); rectum: 9 nTPM (protected, limit 3); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 3); duodenum: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 3); esophagus: 6.7 nTPM (protected, limit 3); thymus: 6.5 nTPM (manageable, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 4.9 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006459,KDM7A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3548% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 36.2205% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.0159% (minimum 75%, Baseline (adaptation disabled)); colon: 53.1792% (minimum 70%, Baseline (adaptation disabled)); duodenum: 53.4884% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.8616% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.2290% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.4409% (minimum 75%, Baseline (adaptation disabled)); liver: 58.5987% (minimum 75%, Baseline (adaptation disabled)); lung: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.5000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 67.6471% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.6970% (minimum 70%, Baseline (adaptation disabled)); rectum: 50.5495% (minimum 70%, Baseline (adaptation disabled)); retina: 61.7450% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.2482% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 42.9907% (minimum 75%, Baseline (adaptation disabled)); skin: 55.7576% (minimum 65%, Baseline (adaptation disabled)); small intestine: 53.1792% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.6567% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.0137% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.2732% (minimum 70%, Baseline (adaptation disabled)); thymus: 58.5987% (minimum 65%, Baseline (adaptation disabled)); tongue: 42.0091% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.5850% (minimum 70%, Baseline (adaptation disabled))",-0.0924242,-0.279909,-0.387795,0,1,partial,16.2,12.7,7.3,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); rectum: 9 nTPM (protected, limit 3); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 3); duodenum: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 3); esophagus: 6.7 nTPM (protected, limit 3); thymus: 6.5 nTPM (manageable, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 4.9 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006459,KDM7A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.6577% (minimum 99%, Missing); basal ganglia: 98.0000% (minimum 99%, Missing); bone marrow: 96.0784% (minimum 99%, Missing); cerebellum: 98.0000% (minimum 99%, Missing); cerebral cortex: 98.6577% (minimum 99%, Missing); duodenum: 98.6577% (minimum 99%, Missing); hippocampal formation: 98.6577% (minimum 99%, Missing); hypothalamus: 98.6577% (minimum 99%, Missing); kidney: 98.6577% (minimum 99%, Missing); lymph node: 96.7105% (minimum 97%, Missing); retina: 98.6577% (minimum 99%, Missing); small intestine: 98.0000% (minimum 99%, Missing)",0.0107843,-0.00289474,-0.0292157,0,80,unavailable,0.6,0.5,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006634,DBF4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.310784,0.267105,0.210784,0,80,unavailable,0.6,0.5,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006634,DBF4,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.310784,0.267105,0.210784,0,80,unavailable,0.6,0.5,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006634,DBF4,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.310784,0.267105,0.210784,0,80,unavailable,0.6,0.5,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006634,DBF4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.310784,0.267105,0.210784,0,80,unavailable,0.6,0.5,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006634,DBF4,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.0360248,0.0237402,0.0021875,0,80,unavailable,0.5,0.4,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006659,LGALS14,admission_only,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.336025,0.29374,0.242188,0,80,unavailable,0.5,0.4,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006659,LGALS14,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.336025,0.29374,0.242188,0,80,unavailable,0.5,0.4,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006659,LGALS14,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.336025,0.29374,0.242188,0,80,unavailable,0.5,0.4,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006659,LGALS14,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.336025,0.29374,0.242188,0,80,unavailable,0.5,0.4,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006659,LGALS14,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.6667% (minimum 99%, Missing); amygdala: 83.5294% (minimum 99%, Missing); basal ganglia: 87.6543% (minimum 99%, Missing); bone marrow: 98.6111% (minimum 99%, Missing); cerebellum: 91.0256% (minimum 99%, Missing); cerebral cortex: 85.5422% (minimum 99%, Missing); choroid plexus: 89.8734% (minimum 99%, Missing); colon: 94.6667% (minimum 97%, Missing); duodenum: 97.9310% (minimum 99%, Missing); esophagus: 95.9459% (minimum 97%, Missing); heart muscle: 85.5422% (minimum 99%, Missing); hippocampal formation: 84.5238% (minimum 99%, Missing); hypothalamus: 84.0237% (minimum 99%, Missing); kidney: 90.4459% (minimum 99%, Missing); liver: 95.3020% (minimum 99%, Missing); lung: 96.5986% (minimum 99%, Missing); lymph node: 95.3020% (minimum 97%, Missing); midbrain: 82.5581% (minimum 99%, Missing); pancreas: 96.5986% (minimum 99%, Missing); parathyroid gland: 94.0397% (minimum 97%, Missing); pituitary gland: 95.9459% (minimum 99%, Missing); rectum: 95.9459% (minimum 97%, Missing); retina: 77.1739% (minimum 99%, Missing); skeletal muscle: 82.0809% (minimum 99%, Missing); small intestine: 95.9459% (minimum 99%, Missing); smooth muscle: 91.0256% (minimum 99%, Missing); spinal cord: 83.0409% (minimum 99%, Missing); stomach: 96.5986% (minimum 97%, Missing); thymus: 94.0397% (minimum 95%, Missing); thyroid gland: 92.8105% (minimum 95%, Missing); tongue: 82.0809% (minimum 97%, Missing); urinary bladder: 95.9459% (minimum 97%, Missing)",-0.0218954,-0.149191,-0.218261,0,80,unavailable,4.2,3.1,1.1,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006837,CDKL3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278105,0.120809,0.0217391,0,80,unavailable,4.2,3.1,1.1,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006837,CDKL3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278105,0.120809,0.0217391,0,80,unavailable,4.2,3.1,1.1,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006837,CDKL3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278105,0.120809,0.0217391,0,80,unavailable,4.2,3.1,1.1,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006837,CDKL3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278105,0.120809,0.0217391,0,80,unavailable,4.2,3.1,1.1,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000006837,CDKL3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 91.4444% (minimum 95%, Enhanced); lung: 97.1665% (minimum 99%, Missing); pancreas: 97.6275% (minimum 99%, Missing)",0.0368106,0.00528376,-0.0355556,0,5,partial,7.7,19.9,1.7,"salivary gland: 19.9 nTPM (protected, limit 12); bone marrow: 7.7 nTPM (vital, limit 6); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007038,PRSS21,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.336811,0.255284,0.221665,0,5,partial,7.7,19.9,1.7,"salivary gland: 19.9 nTPM (protected, limit 12); bone marrow: 7.7 nTPM (vital, limit 6); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007038,PRSS21,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.336811,0.255284,0.221665,0,5,partial,7.7,19.9,1.7,"salivary gland: 19.9 nTPM (protected, limit 12); bone marrow: 7.7 nTPM (vital, limit 6); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007038,PRSS21,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.336811,0.255284,0.221665,0,5,partial,7.7,19.9,1.7,"salivary gland: 19.9 nTPM (protected, limit 12); bone marrow: 7.7 nTPM (vital, limit 6); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007038,PRSS21,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.329762,0.105284,0.164444,0,5,partial,7.7,19.9,1.7,"salivary gland: 19.9 nTPM (protected, limit 3); bone marrow: 7.7 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007038,PRSS21,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 80.9976% (minimum 99%, Missing); basal ganglia: 80.0469% (minimum 99%, Missing); cerebral cortex: 85.4637% (minimum 95%, Enhanced); choroid plexus: 73.6501% (minimum 99%, Missing); hippocampal formation: 72.3992% (minimum 99%, Missing); hypothalamus: 74.7807% (minimum 99%, Missing); lung: 92.6630% (minimum 95%, Enhanced); midbrain: 88.8021% (minimum 99%, Missing); pancreas: 94.9861% (minimum 95%, Enhanced); pituitary gland: 91.6667% (minimum 99%, Missing); retina: 84.1975% (minimum 99%, Missing); spinal cord: 91.4209% (minimum 99%, Missing)",0.047076,0.027076,-0.266008,0,4,partial,13,3.5,2,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007174,DNAH9,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 73.6501% (minimum 75%, Missing); hippocampal formation: 72.3992% (minimum 75%, Missing); hypothalamus: 74.7807% (minimum 75%, Missing)",0.347076,0.297076,-0.0260085,0,4,partial,13,3.5,2,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007174,DNAH9,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 73.6501% (minimum 75%, Missing); hippocampal formation: 72.3992% (minimum 75%, Missing); hypothalamus: 74.7807% (minimum 75%, Missing)",0.347076,0.297076,-0.0260085,0,4,partial,13,3.5,2,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007174,DNAH9,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 73.6501% (minimum 75%, Missing); hippocampal formation: 72.3992% (minimum 75%, Missing); hypothalamus: 74.7807% (minimum 75%, Missing)",0.347076,0.297076,-0.0260085,0,4,partial,13,3.5,2,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007174,DNAH9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 73.6501% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.3992% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.7807% (minimum 75%, Baseline (adaptation disabled))",0.294598,0.206915,-0.0260085,0,4,partial,13,3.5,2,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007174,DNAH9,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.3267% (minimum 99%, Missing)",0.046769,0.0259645,-0.00673307,0,2,partial,3.7,0.5,0.7,"retina: 2.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007350,TKTL1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346769,0.295964,0.233267,0,2,partial,3.7,0.5,0.7,"retina: 2.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007350,TKTL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346769,0.295964,0.233267,0,2,partial,3.7,0.5,0.7,"retina: 2.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007350,TKTL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346769,0.295964,0.233267,0,2,partial,3.7,0.5,0.7,"retina: 2.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007350,TKTL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344359,0.295964,0.220889,0,2,partial,3.7,0.5,0.7,"heart muscle: 3.7 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000007350,TKTL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.3891% (minimum 95%, Missing); adrenal gland: 76.9424% (minimum 99%, Missing); amygdala: 68.2222% (minimum 99%, Missing); basal ganglia: 61.4000% (minimum 99%, Missing); bone marrow: 80.3665% (minimum 99%, Missing); cerebellum: 62.0202% (minimum 99%, Missing); cerebral cortex: 57.8154% (minimum 99%, Missing); choroid plexus: 87.7143% (minimum 99%, Missing); colon: 63.5611% (minimum 97%, Missing); duodenum: 65.7388% (minimum 99%, Uncertain); esophagus: 69.3002% (minimum 97%, Uncertain); heart muscle: 52.6587% (minimum 99%, Missing); hippocampal formation: 65.4584% (minimum 99%, Missing); hypothalamus: 75.0611% (minimum 99%, Missing); kidney: 68.9888% (minimum 99%, Missing); liver: 88.4726% (minimum 99%, Uncertain); lung: 61.6466% (minimum 99%, Missing); lymph node: 85.5153% (minimum 97%, Missing); midbrain: 70.0913% (minimum 99%, Missing); pancreas: 80.7895% (minimum 99%, Uncertain); parathyroid gland: 73.4450% (minimum 97%, Missing); pituitary gland: 76.1787% (minimum 99%, Missing); rectum: 82.0856% (minimum 97%, Uncertain); retina: 84.8066% (minimum 99%, Missing); salivary gland: 72.7488% (minimum 97%, Uncertain); skeletal muscle: 67.7704% (minimum 99%, Missing); skin: 59.4961% (minimum 95%, Missing); small intestine: 65.4584% (minimum 99%, Uncertain); smooth muscle: 72.5768% (minimum 99%, Missing); spinal cord: 81.4324% (minimum 99%, Missing); spleen: 74.1546% (minimum 95%, Uncertain); stomach: 69.4570% (minimum 97%, Missing); thymus: 84.5730% (minimum 95%, Missing); thyroid gland: 53.2986% (minimum 95%, Missing); tongue: 61.7706% (minimum 97%, Missing); urinary bladder: 69.6145% (minimum 97%, Uncertain)",-0.426109,-0.352294,-0.463413,0,5,partial,27.6,19,27.9,"adipose tissue: 27.9 nTPM (manageable, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (manageable, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); skin: 20.9 nTPM (manageable, limit 5); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 2); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 2); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 2); stomach: 13.5 nTPM (protected, limit 2); urinary bladder: 13.4 nTPM (protected, limit 2); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); parathyroid gland: 11.1 nTPM (protected, limit 2); spleen: 10.7 nTPM (manageable, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); thymus: 5.6 nTPM (manageable, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000008256,CYTH3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.3891% (minimum 65%, Missing); amygdala: 68.2222% (minimum 75%, Missing); basal ganglia: 61.4000% (minimum 75%, Missing); cerebellum: 62.0202% (minimum 75%, Missing); cerebral cortex: 57.8154% (minimum 75%, Missing); colon: 63.5611% (minimum 70%, Missing); duodenum: 65.7388% (minimum 75%, Uncertain); esophagus: 69.3002% (minimum 70%, Uncertain); heart muscle: 52.6587% (minimum 75%, Missing); hippocampal formation: 65.4584% (minimum 75%, Missing); kidney: 68.9888% (minimum 75%, Missing); lung: 61.6466% (minimum 75%, Missing); midbrain: 70.0913% (minimum 75%, Missing); skeletal muscle: 67.7704% (minimum 75%, Missing); skin: 59.4961% (minimum 65%, Missing); small intestine: 65.4584% (minimum 75%, Uncertain); smooth muscle: 72.5768% (minimum 75%, Missing); stomach: 69.4570% (minimum 70%, Missing); thyroid gland: 53.2986% (minimum 65%, Missing); tongue: 61.7706% (minimum 70%, Missing); urinary bladder: 69.6145% (minimum 70%, Uncertain)",-0.126109,-0.0822938,-0.223413,0,5,partial,27.6,19,27.9,"adipose tissue: 27.9 nTPM (manageable, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (manageable, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); skin: 20.9 nTPM (manageable, limit 5); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 2); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 2); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 2); stomach: 13.5 nTPM (protected, limit 2); urinary bladder: 13.4 nTPM (protected, limit 2); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); parathyroid gland: 11.1 nTPM (protected, limit 2); spleen: 10.7 nTPM (manageable, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); thymus: 5.6 nTPM (manageable, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000008256,CYTH3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.3891% (minimum 65%, Missing); amygdala: 68.2222% (minimum 75%, Missing); basal ganglia: 61.4000% (minimum 75%, Missing); cerebellum: 62.0202% (minimum 75%, Missing); cerebral cortex: 57.8154% (minimum 75%, Missing); colon: 63.5611% (minimum 70%, Missing); duodenum: 65.7388% (minimum 75%, Uncertain); esophagus: 69.3002% (minimum 70%, Uncertain); heart muscle: 52.6587% (minimum 75%, Missing); hippocampal formation: 65.4584% (minimum 75%, Missing); kidney: 68.9888% (minimum 75%, Missing); lung: 61.6466% (minimum 75%, Missing); midbrain: 70.0913% (minimum 75%, Missing); skeletal muscle: 67.7704% (minimum 75%, Missing); skin: 59.4961% (minimum 65%, Missing); small intestine: 65.4584% (minimum 75%, Uncertain); smooth muscle: 72.5768% (minimum 75%, Missing); stomach: 69.4570% (minimum 70%, Missing); thyroid gland: 53.2986% (minimum 65%, Missing); tongue: 61.7706% (minimum 70%, Missing); urinary bladder: 69.6145% (minimum 70%, Uncertain)",-0.126109,-0.0822938,-0.223413,0,5,partial,27.6,19,27.9,"adipose tissue: 27.9 nTPM (manageable, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (manageable, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); skin: 20.9 nTPM (manageable, limit 5); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 3); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 3); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 3); stomach: 13.5 nTPM (protected, limit 3); urinary bladder: 13.4 nTPM (protected, limit 3); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); parathyroid gland: 11.1 nTPM (protected, limit 3); spleen: 10.7 nTPM (manageable, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); thymus: 5.6 nTPM (manageable, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 3); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000008256,CYTH3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.3891% (minimum 65%, Missing); amygdala: 68.2222% (minimum 75%, Missing); basal ganglia: 61.4000% (minimum 75%, Missing); cerebellum: 62.0202% (minimum 75%, Missing); cerebral cortex: 57.8154% (minimum 75%, Missing); colon: 63.5611% (minimum 70%, Missing); duodenum: 65.7388% (minimum 75%, Uncertain); esophagus: 69.3002% (minimum 70%, Uncertain); heart muscle: 52.6587% (minimum 75%, Missing); hippocampal formation: 65.4584% (minimum 75%, Missing); kidney: 68.9888% (minimum 75%, Missing); lung: 61.6466% (minimum 75%, Missing); midbrain: 70.0913% (minimum 75%, Missing); skeletal muscle: 67.7704% (minimum 75%, Missing); skin: 59.4961% (minimum 65%, Missing); small intestine: 65.4584% (minimum 75%, Uncertain); smooth muscle: 72.5768% (minimum 75%, Missing); stomach: 69.4570% (minimum 70%, Missing); thyroid gland: 53.2986% (minimum 65%, Missing); tongue: 61.7706% (minimum 70%, Missing); urinary bladder: 69.6145% (minimum 70%, Uncertain)",-0.126109,-0.0822938,-0.223413,0,5,partial,27.6,19,27.9,"adipose tissue: 27.9 nTPM (manageable, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (manageable, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); skin: 20.9 nTPM (manageable, limit 5); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 3); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 3); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 3); stomach: 13.5 nTPM (protected, limit 3); urinary bladder: 13.4 nTPM (protected, limit 3); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); parathyroid gland: 11.1 nTPM (protected, limit 3); spleen: 10.7 nTPM (manageable, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); thymus: 5.6 nTPM (manageable, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 3); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000008256,CYTH3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.3891% (minimum 65%, Baseline (adaptation disabled)); amygdala: 68.2222% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.4000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.0202% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.8154% (minimum 75%, Baseline (adaptation disabled)); colon: 63.5611% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.7388% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.3002% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.6587% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.4584% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.9888% (minimum 75%, Baseline (adaptation disabled)); lung: 61.6466% (minimum 75%, Baseline (adaptation disabled)); midbrain: 70.0913% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 67.7704% (minimum 75%, Baseline (adaptation disabled)); skin: 59.4961% (minimum 65%, Baseline (adaptation disabled)); small intestine: 65.4584% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.5768% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.4570% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.2986% (minimum 65%, Baseline (adaptation disabled)); tongue: 61.7706% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 69.6145% (minimum 70%, Baseline (adaptation disabled))",-0.126109,-0.0822938,-0.223413,0,5,partial,27.6,19,27.9,"adipose tissue: 27.9 nTPM (manageable, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (manageable, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); skin: 20.9 nTPM (manageable, limit 5); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 3); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 3); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 3); stomach: 13.5 nTPM (protected, limit 3); urinary bladder: 13.4 nTPM (protected, limit 3); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); parathyroid gland: 11.1 nTPM (protected, limit 3); spleen: 10.7 nTPM (manageable, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); thymus: 5.6 nTPM (manageable, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 3); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000008256,CYTH3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.2308% (minimum 99%, Missing); amygdala: 55.0612% (minimum 99%, Missing); basal ganglia: 59.7105% (minimum 99%, Missing); bone marrow: 65.0460% (minimum 95%, Enhanced); cerebellum: 67.5307% (minimum 99%, Missing); cerebral cortex: 45.2055% (minimum 99%, Missing); choroid plexus: 71.7391% (minimum 99%, Missing); colon: 68.9415% (minimum 97%, Missing); duodenum: 71.2230% (minimum 99%, Missing); esophagus: 63.7066% (minimum 97%, Missing); heart muscle: 69.5225% (minimum 95%, Enhanced); hippocampal formation: 55.3073% (minimum 99%, Missing); hypothalamus: 61.7207% (minimum 99%, Missing); kidney: 60.8108% (minimum 99%, Missing); liver: 60.7362% (minimum 95%, Enhanced); lung: 63.0573% (minimum 99%, Missing); lymph node: 78.6963% (minimum 80%, Enhanced); midbrain: 51.2953% (minimum 99%, Missing); pancreas: 62.5000% (minimum 99%, Missing); parathyroid gland: 65.1316% (minimum 97%, Missing); pituitary gland: 81.4145% (minimum 99%, Missing); rectum: 72.1574% (minimum 97%, Missing); retina: 58.0986% (minimum 99%, Missing); skeletal muscle: 51.8325% (minimum 95%, Enhanced); skin: 72.3684% (minimum 95%, Missing); small intestine: 70.8155% (minimum 99%, Missing); smooth muscle: 65.3897% (minimum 95%, Enhanced); spinal cord: 42.7461% (minimum 99%, Missing); stomach: 76.7442% (minimum 97%, Missing); thymus: 72.4744% (minimum 95%, Missing); thyroid gland: 55.9322% (minimum 95%, Missing); tongue: 55.8061% (minimum 97%, Missing); urinary bladder: 63.3803% (minimum 97%, Missing)",-0.390678,-0.411939,-0.562539,0,4,partial,66.3,39.2,39,"spinal cord: 66.3 nTPM (vital, limit 1); cerebral cortex: 60 nTPM (vital, limit 1); midbrain: 47 nTPM (vital, limit 1); skeletal muscle: 46 nTPM (vital, limit 6); amygdala: 40.4 nTPM (vital, limit 1); hippocampal formation: 40 nTPM (vital, limit 1); tongue: 39.2 nTPM (protected, limit 2); thyroid gland: 39 nTPM (manageable, limit 5); retina: 35.7 nTPM (vital, limit 1); basal ganglia: 33.4 nTPM (vital, limit 1); liver: 32 nTPM (vital, limit 6); kidney: 31.9 nTPM (vital, limit 1); adipose tissue: 31.2 nTPM (manageable, limit 30); hypothalamus: 30.7 nTPM (vital, limit 1); pancreas: 29.7 nTPM (vital, limit 1); lung: 29 nTPM (vital, limit 1); urinary bladder: 28.6 nTPM (protected, limit 2); esophagus: 28.2 nTPM (protected, limit 2); bone marrow: 26.6 nTPM (vital, limit 6); parathyroid gland: 26.5 nTPM (protected, limit 2); smooth muscle: 26.2 nTPM (vital, limit 6); cerebellum: 23.8 nTPM (vital, limit 1); colon: 22.3 nTPM (protected, limit 2); adrenal gland: 22 nTPM (vital, limit 1); heart muscle: 21.7 nTPM (vital, limit 6); small intestine: 20.4 nTPM (vital, limit 1); duodenum: 20 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); rectum: 19.1 nTPM (protected, limit 2); skin: 18.9 nTPM (manageable, limit 5); thymus: 18.8 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); lymph node: 13.4 nTPM (protected, limit 12); pituitary gland: 11.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,False,,,ENSG00000008294,SPAG9,admission_only,True,False,False,False,10.1158/1078-0432.CCR-06-2340,"Garg et al., Clinical Cancer Research (2007)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.2308% (minimum 75%, Missing); amygdala: 55.0612% (minimum 75%, Missing); basal ganglia: 59.7105% (minimum 75%, Missing); cerebellum: 67.5307% (minimum 75%, Missing); cerebral cortex: 45.2055% (minimum 75%, Missing); choroid plexus: 71.7391% (minimum 75%, Missing); colon: 68.9415% (minimum 70%, Missing); duodenum: 71.2230% (minimum 75%, Missing); esophagus: 63.7066% (minimum 70%, Missing); hippocampal formation: 55.3073% (minimum 75%, Missing); hypothalamus: 61.7207% (minimum 75%, Missing); kidney: 60.8108% (minimum 75%, Missing); lung: 63.0573% (minimum 75%, Missing); midbrain: 51.2953% (minimum 75%, Missing); pancreas: 62.5000% (minimum 75%, Missing); parathyroid gland: 65.1316% (minimum 70%, Missing); retina: 58.0986% (minimum 75%, Missing); skeletal muscle: 51.8325% (minimum 60%, Enhanced); small intestine: 70.8155% (minimum 75%, Missing); spinal cord: 42.7461% (minimum 75%, Missing); thyroid gland: 55.9322% (minimum 65%, Missing); tongue: 55.8061% (minimum 70%, Missing); urinary bladder: 63.3803% (minimum 70%, Missing)",-0.090678,-0.141939,-0.322539,0,4,partial,66.3,39.2,39,"spinal cord: 66.3 nTPM (vital, limit 1); cerebral cortex: 60 nTPM (vital, limit 1); midbrain: 47 nTPM (vital, limit 1); skeletal muscle: 46 nTPM (vital, limit 6); amygdala: 40.4 nTPM (vital, limit 1); hippocampal formation: 40 nTPM (vital, limit 1); tongue: 39.2 nTPM (protected, limit 2); thyroid gland: 39 nTPM (manageable, limit 5); retina: 35.7 nTPM (vital, limit 1); basal ganglia: 33.4 nTPM (vital, limit 1); liver: 32 nTPM (vital, limit 6); kidney: 31.9 nTPM (vital, limit 1); adipose tissue: 31.2 nTPM (manageable, limit 30); hypothalamus: 30.7 nTPM (vital, limit 1); pancreas: 29.7 nTPM (vital, limit 1); lung: 29 nTPM (vital, limit 1); urinary bladder: 28.6 nTPM (protected, limit 2); esophagus: 28.2 nTPM (protected, limit 2); bone marrow: 26.6 nTPM (vital, limit 6); parathyroid gland: 26.5 nTPM (protected, limit 2); smooth muscle: 26.2 nTPM (vital, limit 6); cerebellum: 23.8 nTPM (vital, limit 1); colon: 22.3 nTPM (protected, limit 2); adrenal gland: 22 nTPM (vital, limit 1); heart muscle: 21.7 nTPM (vital, limit 6); small intestine: 20.4 nTPM (vital, limit 1); duodenum: 20 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); rectum: 19.1 nTPM (protected, limit 2); skin: 18.9 nTPM (manageable, limit 5); thymus: 18.8 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); lymph node: 13.4 nTPM (protected, limit 12); pituitary gland: 11.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,False,,,ENSG00000008294,SPAG9,selectivity_revised,True,False,False,False,10.1158/1078-0432.CCR-06-2340,"Garg et al., Clinical Cancer Research (2007)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.2308% (minimum 75%, Missing); amygdala: 55.0612% (minimum 75%, Missing); basal ganglia: 59.7105% (minimum 75%, Missing); cerebellum: 67.5307% (minimum 75%, Missing); cerebral cortex: 45.2055% (minimum 75%, Missing); choroid plexus: 71.7391% (minimum 75%, Missing); colon: 68.9415% (minimum 70%, Missing); duodenum: 71.2230% (minimum 75%, Missing); esophagus: 63.7066% (minimum 70%, Missing); hippocampal formation: 55.3073% (minimum 75%, Missing); hypothalamus: 61.7207% (minimum 75%, Missing); kidney: 60.8108% (minimum 75%, Missing); lung: 63.0573% (minimum 75%, Missing); midbrain: 51.2953% (minimum 75%, Missing); pancreas: 62.5000% (minimum 75%, Missing); parathyroid gland: 65.1316% (minimum 70%, Missing); retina: 58.0986% (minimum 75%, Missing); skeletal muscle: 51.8325% (minimum 60%, Enhanced); small intestine: 70.8155% (minimum 75%, Missing); spinal cord: 42.7461% (minimum 75%, Missing); thyroid gland: 55.9322% (minimum 65%, Missing); tongue: 55.8061% (minimum 70%, Missing); urinary bladder: 63.3803% (minimum 70%, Missing)",-0.090678,-0.141939,-0.322539,0,4,partial,66.3,39.2,39,"spinal cord: 66.3 nTPM (vital, limit 1); cerebral cortex: 60 nTPM (vital, limit 1); midbrain: 47 nTPM (vital, limit 1); skeletal muscle: 46 nTPM (vital, limit 6); amygdala: 40.4 nTPM (vital, limit 1); hippocampal formation: 40 nTPM (vital, limit 1); tongue: 39.2 nTPM (protected, limit 3); thyroid gland: 39 nTPM (manageable, limit 5); retina: 35.7 nTPM (vital, limit 1); basal ganglia: 33.4 nTPM (vital, limit 1); liver: 32 nTPM (vital, limit 6); kidney: 31.9 nTPM (vital, limit 1); adipose tissue: 31.2 nTPM (manageable, limit 30); hypothalamus: 30.7 nTPM (vital, limit 1); pancreas: 29.7 nTPM (vital, limit 1); lung: 29 nTPM (vital, limit 1); urinary bladder: 28.6 nTPM (protected, limit 3); esophagus: 28.2 nTPM (protected, limit 3); bone marrow: 26.6 nTPM (vital, limit 6); parathyroid gland: 26.5 nTPM (protected, limit 3); smooth muscle: 26.2 nTPM (vital, limit 6); cerebellum: 23.8 nTPM (vital, limit 1); colon: 22.3 nTPM (protected, limit 3); adrenal gland: 22 nTPM (vital, limit 1); heart muscle: 21.7 nTPM (vital, limit 6); small intestine: 20.4 nTPM (vital, limit 1); duodenum: 20 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); rectum: 19.1 nTPM (protected, limit 3); skin: 18.9 nTPM (manageable, limit 5); thymus: 18.8 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); lymph node: 13.4 nTPM (protected, limit 12); pituitary gland: 11.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,False,,,ENSG00000008294,SPAG9,grid_revised,True,False,False,False,10.1158/1078-0432.CCR-06-2340,"Garg et al., Clinical Cancer Research (2007)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.2308% (minimum 75%, Missing); amygdala: 55.0612% (minimum 75%, Missing); basal ganglia: 59.7105% (minimum 75%, Missing); cerebellum: 67.5307% (minimum 75%, Missing); cerebral cortex: 45.2055% (minimum 75%, Missing); choroid plexus: 71.7391% (minimum 75%, Missing); colon: 68.9415% (minimum 70%, Missing); duodenum: 71.2230% (minimum 75%, Missing); esophagus: 63.7066% (minimum 70%, Missing); hippocampal formation: 55.3073% (minimum 75%, Missing); hypothalamus: 61.7207% (minimum 75%, Missing); kidney: 60.8108% (minimum 75%, Missing); lung: 63.0573% (minimum 75%, Missing); midbrain: 51.2953% (minimum 75%, Missing); pancreas: 62.5000% (minimum 75%, Missing); parathyroid gland: 65.1316% (minimum 70%, Missing); retina: 58.0986% (minimum 75%, Missing); skeletal muscle: 51.8325% (minimum 60%, Enhanced); small intestine: 70.8155% (minimum 75%, Missing); spinal cord: 42.7461% (minimum 75%, Missing); thyroid gland: 55.9322% (minimum 65%, Missing); tongue: 55.8061% (minimum 70%, Missing); urinary bladder: 63.3803% (minimum 70%, Missing)",-0.090678,-0.141939,-0.322539,0,4,partial,66.3,39.2,39,"spinal cord: 66.3 nTPM (vital, limit 1); cerebral cortex: 60 nTPM (vital, limit 1); midbrain: 47 nTPM (vital, limit 1); skeletal muscle: 46 nTPM (vital, limit 6); amygdala: 40.4 nTPM (vital, limit 1); hippocampal formation: 40 nTPM (vital, limit 1); tongue: 39.2 nTPM (protected, limit 3); thyroid gland: 39 nTPM (manageable, limit 5); retina: 35.7 nTPM (vital, limit 1); basal ganglia: 33.4 nTPM (vital, limit 1); liver: 32 nTPM (vital, limit 6); kidney: 31.9 nTPM (vital, limit 1); adipose tissue: 31.2 nTPM (manageable, limit 30); hypothalamus: 30.7 nTPM (vital, limit 1); pancreas: 29.7 nTPM (vital, limit 1); lung: 29 nTPM (vital, limit 1); urinary bladder: 28.6 nTPM (protected, limit 3); esophagus: 28.2 nTPM (protected, limit 3); bone marrow: 26.6 nTPM (vital, limit 6); parathyroid gland: 26.5 nTPM (protected, limit 3); smooth muscle: 26.2 nTPM (vital, limit 6); cerebellum: 23.8 nTPM (vital, limit 1); colon: 22.3 nTPM (protected, limit 3); adrenal gland: 22 nTPM (vital, limit 1); heart muscle: 21.7 nTPM (vital, limit 6); small intestine: 20.4 nTPM (vital, limit 1); duodenum: 20 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); rectum: 19.1 nTPM (protected, limit 3); skin: 18.9 nTPM (manageable, limit 5); thymus: 18.8 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); lymph node: 13.4 nTPM (protected, limit 12); pituitary gland: 11.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,False,,,ENSG00000008294,SPAG9,current_adaptive,True,False,False,False,10.1158/1078-0432.CCR-06-2340,"Garg et al., Clinical Cancer Research (2007)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.3383% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 69.2308% (minimum 75%, Baseline (adaptation disabled)); amygdala: 55.0612% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 59.7105% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 65.0460% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.5307% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 45.2055% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 71.7391% (minimum 75%, Baseline (adaptation disabled)); colon: 68.9415% (minimum 70%, Baseline (adaptation disabled)); duodenum: 71.2230% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.7066% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.5225% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.3073% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.7207% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.8108% (minimum 75%, Baseline (adaptation disabled)); liver: 60.7362% (minimum 75%, Baseline (adaptation disabled)); lung: 63.0573% (minimum 75%, Baseline (adaptation disabled)); midbrain: 51.2953% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.5000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.1316% (minimum 70%, Baseline (adaptation disabled)); retina: 58.0986% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 51.8325% (minimum 75%, Baseline (adaptation disabled)); small intestine: 70.8155% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.3897% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 42.7461% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 55.9322% (minimum 65%, Baseline (adaptation disabled)); tongue: 55.8061% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.3803% (minimum 70%, Baseline (adaptation disabled))",-0.090678,-0.141939,-0.322539,0,4,partial,66.3,39.2,39,"spinal cord: 66.3 nTPM (vital, limit 1); cerebral cortex: 60 nTPM (vital, limit 1); midbrain: 47 nTPM (vital, limit 1); skeletal muscle: 46 nTPM (vital, limit 1); amygdala: 40.4 nTPM (vital, limit 1); hippocampal formation: 40 nTPM (vital, limit 1); tongue: 39.2 nTPM (protected, limit 3); thyroid gland: 39 nTPM (manageable, limit 5); retina: 35.7 nTPM (vital, limit 1); basal ganglia: 33.4 nTPM (vital, limit 1); liver: 32 nTPM (vital, limit 1); kidney: 31.9 nTPM (vital, limit 1); adipose tissue: 31.2 nTPM (manageable, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); pancreas: 29.7 nTPM (vital, limit 1); lung: 29 nTPM (vital, limit 1); urinary bladder: 28.6 nTPM (protected, limit 3); esophagus: 28.2 nTPM (protected, limit 3); bone marrow: 26.6 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 3); smooth muscle: 26.2 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); colon: 22.3 nTPM (protected, limit 3); adrenal gland: 22 nTPM (vital, limit 1); heart muscle: 21.7 nTPM (vital, limit 1); small intestine: 20.4 nTPM (vital, limit 1); duodenum: 20 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); rectum: 19.1 nTPM (protected, limit 3); skin: 18.9 nTPM (manageable, limit 5); thymus: 18.8 nTPM (manageable, limit 5); spleen: 18 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); lymph node: 13.4 nTPM (protected, limit 3); pituitary gland: 11.3 nTPM (vital, limit 1); salivary gland: 10.8 nTPM (protected, limit 3)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,False,,,ENSG00000008294,SPAG9,current_fixed,True,False,False,False,10.1158/1078-0432.CCR-06-2340,"Garg et al., Clinical Cancer Research (2007)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6958% (minimum 95%, Missing); adrenal gland: 60.2837% (minimum 99%, Missing); amygdala: 70.8333% (minimum 99%, Missing); basal ganglia: 66.2338% (minimum 99%, Missing); bone marrow: 61.4458% (minimum 99%, Missing); cerebellum: 57.0470% (minimum 99%, Missing); cerebral cortex: 61.0048% (minimum 99%, Missing); choroid plexus: 65.7216% (minimum 99%, Missing); colon: 54.1401% (minimum 97%, Missing); duodenum: 56.7929% (minimum 99%, Missing); esophagus: 48.2955% (minimum 97%, Missing); heart muscle: 48.1132% (minimum 99%, Missing); hippocampal formation: 70.0549% (minimum 99%, Missing); hypothalamus: 71.2291% (minimum 99%, Missing); kidney: 56.5410% (minimum 99%, Missing); liver: 53.3473% (minimum 99%, Missing); lung: 58.0866% (minimum 99%, Missing); lymph node: 55.4348% (minimum 95%, Approved); midbrain: 70.0549% (minimum 99%, Missing); pancreas: 54.0254% (minimum 99%, Missing); parathyroid gland: 42.1488% (minimum 97%, Missing); pituitary gland: 70.2479% (minimum 99%, Missing); rectum: 53.1250% (minimum 97%, Missing); retina: 56.5410% (minimum 99%, Missing); salivary gland: 53.5714% (minimum 97%, Missing); skeletal muscle: 28.7162% (minimum 99%, Missing); skin: 55.7987% (minimum 95%, Missing); small intestine: 55.6769% (minimum 99%, Missing); smooth muscle: 47.5746% (minimum 98%, Approved); spinal cord: 66.7539% (minimum 99%, Missing); spleen: 59.3023% (minimum 95%, Missing); stomach: 55.5556% (minimum 97%, Missing); thymus: 58.4862% (minimum 95%, Missing); thyroid gland: 60.2837% (minimum 95%, Missing); tongue: 31.1736% (minimum 97%, Missing); urinary bladder: 48.4791% (minimum 97%, Missing)",-0.443042,-0.658264,-0.702838,0,7,partial,63.3,56.3,24.8,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 2); parathyroid gland: 35 nTPM (protected, limit 2); smooth muscle: 28.1 nTPM (vital, limit 2); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 2); urinary bladder: 27.1 nTPM (protected, limit 2); adipose tissue: 24.8 nTPM (manageable, limit 5); rectum: 22.5 nTPM (protected, limit 2); liver: 22.3 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 2); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 2); lymph node: 20.5 nTPM (protected, limit 4); stomach: 20.4 nTPM (protected, limit 2); small intestine: 20.3 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); thymus: 18.1 nTPM (manageable, limit 5); spleen: 17.5 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (manageable, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000009335,UBE3C,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6958% (minimum 65%, Missing); adrenal gland: 60.2837% (minimum 75%, Missing); amygdala: 70.8333% (minimum 75%, Missing); basal ganglia: 66.2338% (minimum 75%, Missing); bone marrow: 61.4458% (minimum 75%, Missing); cerebellum: 57.0470% (minimum 75%, Missing); cerebral cortex: 61.0048% (minimum 75%, Missing); choroid plexus: 65.7216% (minimum 75%, Missing); colon: 54.1401% (minimum 70%, Missing); duodenum: 56.7929% (minimum 75%, Missing); esophagus: 48.2955% (minimum 70%, Missing); heart muscle: 48.1132% (minimum 75%, Missing); hippocampal formation: 70.0549% (minimum 75%, Missing); hypothalamus: 71.2291% (minimum 75%, Missing); kidney: 56.5410% (minimum 75%, Missing); liver: 53.3473% (minimum 75%, Missing); lung: 58.0866% (minimum 75%, Missing); lymph node: 55.4348% (minimum 65%, Approved); midbrain: 70.0549% (minimum 75%, Missing); pancreas: 54.0254% (minimum 75%, Missing); parathyroid gland: 42.1488% (minimum 70%, Missing); pituitary gland: 70.2479% (minimum 75%, Missing); rectum: 53.1250% (minimum 70%, Missing); retina: 56.5410% (minimum 75%, Missing); salivary gland: 53.5714% (minimum 70%, Missing); skeletal muscle: 28.7162% (minimum 75%, Missing); skin: 55.7987% (minimum 65%, Missing); small intestine: 55.6769% (minimum 75%, Missing); smooth muscle: 47.5746% (minimum 70%, Approved); spinal cord: 66.7539% (minimum 75%, Missing); spleen: 59.3023% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 58.4862% (minimum 65%, Missing); thyroid gland: 60.2837% (minimum 65%, Missing); tongue: 31.1736% (minimum 70%, Missing); urinary bladder: 48.4791% (minimum 70%, Missing)",-0.143042,-0.388264,-0.462838,0,7,partial,63.3,56.3,24.8,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 2); parathyroid gland: 35 nTPM (protected, limit 2); smooth muscle: 28.1 nTPM (vital, limit 2); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 2); urinary bladder: 27.1 nTPM (protected, limit 2); adipose tissue: 24.8 nTPM (manageable, limit 5); rectum: 22.5 nTPM (protected, limit 2); liver: 22.3 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 2); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 2); lymph node: 20.5 nTPM (protected, limit 4); stomach: 20.4 nTPM (protected, limit 2); small intestine: 20.3 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); thymus: 18.1 nTPM (manageable, limit 5); spleen: 17.5 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (manageable, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000009335,UBE3C,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6958% (minimum 65%, Missing); adrenal gland: 60.2837% (minimum 75%, Missing); amygdala: 70.8333% (minimum 75%, Missing); basal ganglia: 66.2338% (minimum 75%, Missing); bone marrow: 61.4458% (minimum 75%, Missing); cerebellum: 57.0470% (minimum 75%, Missing); cerebral cortex: 61.0048% (minimum 75%, Missing); choroid plexus: 65.7216% (minimum 75%, Missing); colon: 54.1401% (minimum 70%, Missing); duodenum: 56.7929% (minimum 75%, Missing); esophagus: 48.2955% (minimum 70%, Missing); heart muscle: 48.1132% (minimum 75%, Missing); hippocampal formation: 70.0549% (minimum 75%, Missing); hypothalamus: 71.2291% (minimum 75%, Missing); kidney: 56.5410% (minimum 75%, Missing); liver: 53.3473% (minimum 75%, Missing); lung: 58.0866% (minimum 75%, Missing); lymph node: 55.4348% (minimum 65%, Approved); midbrain: 70.0549% (minimum 75%, Missing); pancreas: 54.0254% (minimum 75%, Missing); parathyroid gland: 42.1488% (minimum 70%, Missing); pituitary gland: 70.2479% (minimum 75%, Missing); rectum: 53.1250% (minimum 70%, Missing); retina: 56.5410% (minimum 75%, Missing); salivary gland: 53.5714% (minimum 70%, Missing); skeletal muscle: 28.7162% (minimum 75%, Missing); skin: 55.7987% (minimum 65%, Missing); small intestine: 55.6769% (minimum 75%, Missing); smooth muscle: 47.5746% (minimum 70%, Approved); spinal cord: 66.7539% (minimum 75%, Missing); spleen: 59.3023% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 58.4862% (minimum 65%, Missing); thyroid gland: 60.2837% (minimum 65%, Missing); tongue: 31.1736% (minimum 70%, Missing); urinary bladder: 48.4791% (minimum 70%, Missing)",-0.143042,-0.388264,-0.462838,0,7,partial,63.3,56.3,24.8,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 3); parathyroid gland: 35 nTPM (protected, limit 3); smooth muscle: 28.1 nTPM (vital, limit 2); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 3); urinary bladder: 27.1 nTPM (protected, limit 3); adipose tissue: 24.8 nTPM (manageable, limit 5); rectum: 22.5 nTPM (protected, limit 3); liver: 22.3 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 3); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 3); lymph node: 20.5 nTPM (protected, limit 4); stomach: 20.4 nTPM (protected, limit 3); small intestine: 20.3 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); thymus: 18.1 nTPM (manageable, limit 5); spleen: 17.5 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (manageable, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000009335,UBE3C,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6958% (minimum 65%, Missing); adrenal gland: 60.2837% (minimum 75%, Missing); amygdala: 70.8333% (minimum 75%, Missing); basal ganglia: 66.2338% (minimum 75%, Missing); bone marrow: 61.4458% (minimum 75%, Missing); cerebellum: 57.0470% (minimum 75%, Missing); cerebral cortex: 61.0048% (minimum 75%, Missing); choroid plexus: 65.7216% (minimum 75%, Missing); colon: 54.1401% (minimum 70%, Missing); duodenum: 56.7929% (minimum 75%, Missing); esophagus: 48.2955% (minimum 70%, Missing); heart muscle: 48.1132% (minimum 75%, Missing); hippocampal formation: 70.0549% (minimum 75%, Missing); hypothalamus: 71.2291% (minimum 75%, Missing); kidney: 56.5410% (minimum 75%, Missing); liver: 53.3473% (minimum 75%, Missing); lung: 58.0866% (minimum 75%, Missing); lymph node: 55.4348% (minimum 65%, Approved); midbrain: 70.0549% (minimum 75%, Missing); pancreas: 54.0254% (minimum 75%, Missing); parathyroid gland: 42.1488% (minimum 70%, Missing); pituitary gland: 70.2479% (minimum 75%, Missing); rectum: 53.1250% (minimum 70%, Missing); retina: 56.5410% (minimum 75%, Missing); salivary gland: 53.5714% (minimum 70%, Missing); skeletal muscle: 28.7162% (minimum 75%, Missing); skin: 55.7987% (minimum 65%, Missing); small intestine: 55.6769% (minimum 75%, Missing); smooth muscle: 47.5746% (minimum 70%, Approved); spinal cord: 66.7539% (minimum 75%, Missing); spleen: 59.3023% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 58.4862% (minimum 65%, Missing); thyroid gland: 60.2837% (minimum 65%, Missing); tongue: 31.1736% (minimum 70%, Missing); urinary bladder: 48.4791% (minimum 70%, Missing)",-0.143042,-0.388264,-0.462838,0,7,partial,63.3,56.3,24.8,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 3); parathyroid gland: 35 nTPM (protected, limit 3); smooth muscle: 28.1 nTPM (vital, limit 2); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 3); urinary bladder: 27.1 nTPM (protected, limit 3); adipose tissue: 24.8 nTPM (manageable, limit 5); rectum: 22.5 nTPM (protected, limit 3); liver: 22.3 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 3); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 3); lymph node: 20.5 nTPM (protected, limit 4); stomach: 20.4 nTPM (protected, limit 3); small intestine: 20.3 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); thymus: 18.1 nTPM (manageable, limit 5); spleen: 17.5 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (manageable, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000009335,UBE3C,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6958% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.2837% (minimum 75%, Baseline (adaptation disabled)); amygdala: 70.8333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.2338% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.4458% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.0470% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.0048% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 65.7216% (minimum 75%, Baseline (adaptation disabled)); colon: 54.1401% (minimum 70%, Baseline (adaptation disabled)); duodenum: 56.7929% (minimum 75%, Baseline (adaptation disabled)); esophagus: 48.2955% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 48.1132% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.0549% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.2291% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.5410% (minimum 75%, Baseline (adaptation disabled)); liver: 53.3473% (minimum 75%, Baseline (adaptation disabled)); lung: 58.0866% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.4348% (minimum 70%, Baseline (adaptation disabled)); midbrain: 70.0549% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.0254% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 42.1488% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.2479% (minimum 75%, Baseline (adaptation disabled)); rectum: 53.1250% (minimum 70%, Baseline (adaptation disabled)); retina: 56.5410% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.5714% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 28.7162% (minimum 75%, Baseline (adaptation disabled)); skin: 55.7987% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.6769% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 47.5746% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.7539% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.3023% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.5556% (minimum 70%, Baseline (adaptation disabled)); thymus: 58.4862% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 60.2837% (minimum 65%, Baseline (adaptation disabled)); tongue: 31.1736% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 48.4791% (minimum 70%, Baseline (adaptation disabled))",-0.143042,-0.388264,-0.462838,0,7,partial,63.3,56.3,24.8,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 3); parathyroid gland: 35 nTPM (protected, limit 3); smooth muscle: 28.1 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 3); urinary bladder: 27.1 nTPM (protected, limit 3); adipose tissue: 24.8 nTPM (manageable, limit 5); rectum: 22.5 nTPM (protected, limit 3); liver: 22.3 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 3); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 3); lymph node: 20.5 nTPM (protected, limit 3); stomach: 20.4 nTPM (protected, limit 3); small intestine: 20.3 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); thymus: 18.1 nTPM (manageable, limit 5); spleen: 17.5 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (manageable, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000009335,UBE3C,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.0492% (minimum 95%, Uncertain); adrenal gland: 80.1136% (minimum 99%, Missing); amygdala: 84.9398% (minimum 99%, Missing); basal ganglia: 84.9398% (minimum 99%, Missing); bone marrow: 54.6512% (minimum 99%, Missing); cerebellum: 87.0370% (minimum 99%, Missing); cerebral cortex: 76.2162% (minimum 99%, Missing); choroid plexus: 87.0370% (minimum 99%, Missing); colon: 79.6610% (minimum 97%, Missing); duodenum: 78.3333% (minimum 99%, Uncertain); esophagus: 71.9388% (minimum 97%, Uncertain); heart muscle: 76.6304% (minimum 99%, Uncertain); hippocampal formation: 83.4320% (minimum 99%, Missing); hypothalamus: 83.9286% (minimum 99%, Missing); kidney: 76.2162% (minimum 99%, Uncertain); liver: 73.8220% (minimum 99%, Uncertain); lung: 79.6610% (minimum 99%, Uncertain); lymph node: 69.4581% (minimum 97%, Missing); midbrain: 82.9412% (minimum 99%, Missing); pancreas: 84.4311% (minimum 99%, Uncertain); parathyroid gland: 75.4011% (minimum 97%, Uncertain); pituitary gland: 83.9286% (minimum 99%, Missing); rectum: 79.2135% (minimum 97%, Uncertain); retina: 75.0000% (minimum 99%, Missing); salivary gland: 80.5714% (minimum 97%, Uncertain); skeletal muscle: 63.2287% (minimum 99%, Uncertain); skin: 71.2121% (minimum 95%, Missing); small intestine: 80.1136% (minimum 99%, Uncertain); smooth muscle: 75.0000% (minimum 99%, Uncertain); spinal cord: 77.9006% (minimum 99%, Missing); spleen: 74.2105% (minimum 95%, Uncertain); stomach: 77.9006% (minimum 97%, Uncertain); thymus: 66.8246% (minimum 95%, Missing); thyroid gland: 74.2105% (minimum 95%, Missing); tongue: 73.4375% (minimum 97%, Missing); urinary bladder: 75.4011% (minimum 97%, Uncertain)",-0.281754,-0.275419,-0.443488,0,0,routine_complete,11.7,6.2,7,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); thymus: 7 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 2); skin: 5.7 nTPM (manageable, limit 5); esophagus: 5.5 nTPM (protected, limit 2); tongue: 5.1 nTPM (protected, limit 2); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); urinary bladder: 4.6 nTPM (protected, limit 2); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000010072,SPRTN,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 54.6512% (minimum 75%, Missing); liver: 73.8220% (minimum 75%, Uncertain); lymph node: 69.4581% (minimum 70%, Missing); skeletal muscle: 63.2287% (minimum 75%, Uncertain)",0.0182464,-0.00541872,-0.203488,0,0,routine_complete,11.7,6.2,7,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); thymus: 7 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 2); skin: 5.7 nTPM (manageable, limit 5); esophagus: 5.5 nTPM (protected, limit 2); tongue: 5.1 nTPM (protected, limit 2); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); urinary bladder: 4.6 nTPM (protected, limit 2); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000010072,SPRTN,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 54.6512% (minimum 75%, Missing); liver: 73.8220% (minimum 75%, Uncertain); lymph node: 69.4581% (minimum 70%, Missing); skeletal muscle: 63.2287% (minimum 75%, Uncertain)",0.0182464,-0.00541872,-0.203488,0,0,routine_complete,11.7,6.2,7,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); thymus: 7 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 3); skin: 5.7 nTPM (manageable, limit 5); esophagus: 5.5 nTPM (protected, limit 3); tongue: 5.1 nTPM (protected, limit 3); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); urinary bladder: 4.6 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000010072,SPRTN,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 54.6512% (minimum 75%, Missing); liver: 73.8220% (minimum 75%, Uncertain); lymph node: 69.4581% (minimum 70%, Missing); skeletal muscle: 63.2287% (minimum 75%, Uncertain)",0.0182464,-0.00541872,-0.203488,0,0,routine_complete,11.7,6.2,7,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); thymus: 7 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 3); skin: 5.7 nTPM (manageable, limit 5); esophagus: 5.5 nTPM (protected, limit 3); tongue: 5.1 nTPM (protected, limit 3); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); urinary bladder: 4.6 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000010072,SPRTN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 54.6512% (minimum 75%, Baseline (adaptation disabled)); liver: 73.8220% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.4581% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 63.2287% (minimum 75%, Baseline (adaptation disabled))",0.0182464,-0.00541872,-0.203488,0,0,routine_complete,11.7,6.2,7,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); thymus: 7 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 3); skin: 5.7 nTPM (manageable, limit 5); esophagus: 5.5 nTPM (protected, limit 3); tongue: 5.1 nTPM (protected, limit 3); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); urinary bladder: 4.6 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000010072,SPRTN,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0476353,0.0292387,0.00771959,0,2,partial,4.6,5.5,4.9,"choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000010318,PHF7,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347635,0.299239,0.24772,0,2,partial,4.6,5.5,4.9,"choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000010318,PHF7,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347635,0.299239,0.24772,0,2,partial,4.6,5.5,4.9,"choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000010318,PHF7,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347635,0.299239,0.24772,0,2,partial,4.6,5.5,4.9,"choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000010318,PHF7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345869,0.295366,0.246121,0,2,partial,4.6,5.5,4.9,"parathyroid gland: 5.5 nTPM (protected, limit 3); liver: 4.6 nTPM (vital, limit 1); rectum: 4.4 nTPM (protected, limit 3); colon: 4.2 nTPM (protected, limit 3); pancreas: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); kidney: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000010318,PHF7,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 98.7578% (minimum 99%, Missing); lymph node: 93.5294% (minimum 97%, Missing); spleen: 94.8310% (minimum 95%, Missing)",-0.00168986,-0.0347059,-0.00242236,0,6,partial,1.6,3.3,2.6,"lymph node: 3.3 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000011590,ZBTB32,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.29831,0.235294,0.237578,0,6,partial,1.6,3.3,2.6,"lymph node: 3.3 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000011590,ZBTB32,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.29831,0.235294,0.237578,0,6,partial,1.6,3.3,2.6,"lymph node: 3.3 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000011590,ZBTB32,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.29831,0.235294,0.237578,0,6,partial,1.6,3.3,2.6,"lymph node: 3.3 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000011590,ZBTB32,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.29831,0.235294,0.217546,0,6,partial,1.6,3.3,2.6,"lymph node: 3.3 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000011590,ZBTB32,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.2439% (minimum 95%, Missing); adrenal gland: 63.3136% (minimum 99%, Missing); amygdala: 78.1022% (minimum 99%, Missing); basal ganglia: 78.6765% (minimum 99%, Missing); bone marrow: 27.0886% (minimum 99%, Missing); cerebellum: 54.8718% (minimum 99%, Missing); cerebral cortex: 73.2877% (minimum 99%, Missing); choroid plexus: 69.4805% (minimum 99%, Missing); colon: 53.5000% (minimum 97%, Missing); duodenum: 58.1522% (minimum 99%, Missing); esophagus: 53.5000% (minimum 97%, Missing); heart muscle: 67.7215% (minimum 99%, Missing); hippocampal formation: 76.9784% (minimum 99%, Missing); hypothalamus: 77.5362% (minimum 99%, Missing); kidney: 54.3147% (minimum 99%, Missing); liver: 54.0404% (minimum 97%, Supported); lung: 64.4578% (minimum 99%, Missing); lymph node: 45.3390% (minimum 97%, Missing); midbrain: 76.4286% (minimum 99%, Missing); pancreas: 38.6282% (minimum 99%, Missing); parathyroid gland: 65.6442% (minimum 90%, Supported); pituitary gland: 53.7688% (minimum 99%, Missing); rectum: 52.4510% (minimum 97%, Missing); retina: 62.5731% (minimum 99%, Missing); salivary gland: 56.3158% (minimum 97%, Missing); skeletal muscle: 50.9524% (minimum 99%, Missing); skin: 39.6296% (minimum 95%, Missing); small intestine: 45.1477% (minimum 99%, Missing); smooth muscle: 75.8865% (minimum 99%, Missing); spinal cord: 75.8865% (minimum 99%, Missing); spleen: 44.2149% (minimum 95%, Missing); stomach: 53.5000% (minimum 97%, Missing); thymus: 31.3783% (minimum 95%, Missing); thyroid gland: 57.8378% (minimum 95%, Missing); tongue: 63.3136% (minimum 97%, Missing); urinary bladder: 61.4943% (minimum 97%, Missing)",-0.636217,-0.51661,-0.719114,0,7,partial,28.8,12.9,23.4,"bone marrow: 28.8 nTPM (vital, limit 1); thymus: 23.4 nTPM (manageable, limit 5); pancreas: 17 nTPM (vital, limit 1); skin: 16.3 nTPM (manageable, limit 5); spleen: 13.5 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 2); skeletal muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); stomach: 9.3 nTPM (protected, limit 2); colon: 9.3 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 3); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 2); thyroid gland: 7.8 nTPM (manageable, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 2); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000013573,DDX11,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.3136% (minimum 75%, Missing); bone marrow: 27.0886% (minimum 75%, Missing); cerebellum: 54.8718% (minimum 75%, Missing); cerebral cortex: 73.2877% (minimum 75%, Missing); choroid plexus: 69.4805% (minimum 75%, Missing); colon: 53.5000% (minimum 70%, Missing); duodenum: 58.1522% (minimum 75%, Missing); esophagus: 53.5000% (minimum 70%, Missing); heart muscle: 67.7215% (minimum 75%, Missing); kidney: 54.3147% (minimum 75%, Missing); liver: 54.0404% (minimum 65%, Supported); lung: 64.4578% (minimum 75%, Missing); lymph node: 45.3390% (minimum 70%, Missing); pancreas: 38.6282% (minimum 75%, Missing); pituitary gland: 53.7688% (minimum 75%, Missing); rectum: 52.4510% (minimum 70%, Missing); retina: 62.5731% (minimum 75%, Missing); salivary gland: 56.3158% (minimum 70%, Missing); skeletal muscle: 50.9524% (minimum 75%, Missing); skin: 39.6296% (minimum 65%, Missing); small intestine: 45.1477% (minimum 75%, Missing); spleen: 44.2149% (minimum 65%, Missing); stomach: 53.5000% (minimum 70%, Missing); thymus: 31.3783% (minimum 65%, Missing); thyroid gland: 57.8378% (minimum 65%, Missing); tongue: 63.3136% (minimum 70%, Missing); urinary bladder: 61.4943% (minimum 70%, Missing)",-0.336217,-0.24661,-0.479114,0,7,partial,28.8,12.9,23.4,"bone marrow: 28.8 nTPM (vital, limit 1); thymus: 23.4 nTPM (manageable, limit 5); pancreas: 17 nTPM (vital, limit 1); skin: 16.3 nTPM (manageable, limit 5); spleen: 13.5 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 2); skeletal muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); stomach: 9.3 nTPM (protected, limit 2); colon: 9.3 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 3); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 2); thyroid gland: 7.8 nTPM (manageable, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 2); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000013573,DDX11,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.3136% (minimum 75%, Missing); bone marrow: 27.0886% (minimum 75%, Missing); cerebellum: 54.8718% (minimum 75%, Missing); cerebral cortex: 73.2877% (minimum 75%, Missing); choroid plexus: 69.4805% (minimum 75%, Missing); colon: 53.5000% (minimum 70%, Missing); duodenum: 58.1522% (minimum 75%, Missing); esophagus: 53.5000% (minimum 70%, Missing); heart muscle: 67.7215% (minimum 75%, Missing); kidney: 54.3147% (minimum 75%, Missing); liver: 54.0404% (minimum 65%, Supported); lung: 64.4578% (minimum 75%, Missing); lymph node: 45.3390% (minimum 70%, Missing); pancreas: 38.6282% (minimum 75%, Missing); pituitary gland: 53.7688% (minimum 75%, Missing); rectum: 52.4510% (minimum 70%, Missing); retina: 62.5731% (minimum 75%, Missing); salivary gland: 56.3158% (minimum 70%, Missing); skeletal muscle: 50.9524% (minimum 75%, Missing); skin: 39.6296% (minimum 65%, Missing); small intestine: 45.1477% (minimum 75%, Missing); spleen: 44.2149% (minimum 65%, Missing); stomach: 53.5000% (minimum 70%, Missing); thymus: 31.3783% (minimum 65%, Missing); thyroid gland: 57.8378% (minimum 65%, Missing); tongue: 63.3136% (minimum 70%, Missing); urinary bladder: 61.4943% (minimum 70%, Missing)",-0.336217,-0.24661,-0.479114,0,7,partial,28.8,12.9,23.4,"bone marrow: 28.8 nTPM (vital, limit 1); thymus: 23.4 nTPM (manageable, limit 5); pancreas: 17 nTPM (vital, limit 1); skin: 16.3 nTPM (manageable, limit 5); spleen: 13.5 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 3); skeletal muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); stomach: 9.3 nTPM (protected, limit 3); colon: 9.3 nTPM (protected, limit 3); esophagus: 9.3 nTPM (protected, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 3); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 3); thyroid gland: 7.8 nTPM (manageable, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 3); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000013573,DDX11,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.3136% (minimum 75%, Missing); bone marrow: 27.0886% (minimum 75%, Missing); cerebellum: 54.8718% (minimum 75%, Missing); cerebral cortex: 73.2877% (minimum 75%, Missing); choroid plexus: 69.4805% (minimum 75%, Missing); colon: 53.5000% (minimum 70%, Missing); duodenum: 58.1522% (minimum 75%, Missing); esophagus: 53.5000% (minimum 70%, Missing); heart muscle: 67.7215% (minimum 75%, Missing); kidney: 54.3147% (minimum 75%, Missing); liver: 54.0404% (minimum 65%, Supported); lung: 64.4578% (minimum 75%, Missing); lymph node: 45.3390% (minimum 70%, Missing); pancreas: 38.6282% (minimum 75%, Missing); pituitary gland: 53.7688% (minimum 75%, Missing); rectum: 52.4510% (minimum 70%, Missing); retina: 62.5731% (minimum 75%, Missing); salivary gland: 56.3158% (minimum 70%, Missing); skeletal muscle: 50.9524% (minimum 75%, Missing); skin: 39.6296% (minimum 65%, Missing); small intestine: 45.1477% (minimum 75%, Missing); spleen: 44.2149% (minimum 65%, Missing); stomach: 53.5000% (minimum 70%, Missing); thymus: 31.3783% (minimum 65%, Missing); thyroid gland: 57.8378% (minimum 65%, Missing); tongue: 63.3136% (minimum 70%, Missing); urinary bladder: 61.4943% (minimum 70%, Missing)",-0.336217,-0.24661,-0.479114,0,7,partial,28.8,12.9,23.4,"bone marrow: 28.8 nTPM (vital, limit 1); thymus: 23.4 nTPM (manageable, limit 5); pancreas: 17 nTPM (vital, limit 1); skin: 16.3 nTPM (manageable, limit 5); spleen: 13.5 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 3); skeletal muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); stomach: 9.3 nTPM (protected, limit 3); colon: 9.3 nTPM (protected, limit 3); esophagus: 9.3 nTPM (protected, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 3); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 3); thyroid gland: 7.8 nTPM (manageable, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 3); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000013573,DDX11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.3136% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 27.0886% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.8718% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.2877% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.4805% (minimum 75%, Baseline (adaptation disabled)); colon: 53.5000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.1522% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.5000% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 67.7215% (minimum 75%, Baseline (adaptation disabled)); kidney: 54.3147% (minimum 75%, Baseline (adaptation disabled)); liver: 54.0404% (minimum 75%, Baseline (adaptation disabled)); lung: 64.4578% (minimum 75%, Baseline (adaptation disabled)); lymph node: 45.3390% (minimum 70%, Baseline (adaptation disabled)); pancreas: 38.6282% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.6442% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 53.7688% (minimum 75%, Baseline (adaptation disabled)); rectum: 52.4510% (minimum 70%, Baseline (adaptation disabled)); retina: 62.5731% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.3158% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 50.9524% (minimum 75%, Baseline (adaptation disabled)); skin: 39.6296% (minimum 65%, Baseline (adaptation disabled)); small intestine: 45.1477% (minimum 75%, Baseline (adaptation disabled)); spleen: 44.2149% (minimum 65%, Baseline (adaptation disabled)); stomach: 53.5000% (minimum 70%, Baseline (adaptation disabled)); thymus: 31.3783% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.8378% (minimum 65%, Baseline (adaptation disabled)); tongue: 63.3136% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.4943% (minimum 70%, Baseline (adaptation disabled))",-0.336217,-0.24661,-0.479114,0,7,partial,28.8,12.9,23.4,"bone marrow: 28.8 nTPM (vital, limit 1); thymus: 23.4 nTPM (manageable, limit 5); pancreas: 17 nTPM (vital, limit 1); skin: 16.3 nTPM (manageable, limit 5); spleen: 13.5 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 3); skeletal muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); colon: 9.3 nTPM (protected, limit 3); stomach: 9.3 nTPM (protected, limit 3); esophagus: 9.3 nTPM (protected, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 3); thyroid gland: 7.8 nTPM (manageable, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 3); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); parathyroid gland: 5.6 nTPM (protected, limit 3); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000013573,DDX11,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.8166% (minimum 95%, Enhanced); amygdala: 96.8442% (minimum 99%, Missing); basal ganglia: 97.2277% (minimum 99%, Missing); bone marrow: 46.9407% (minimum 99%, Missing); cerebellum: 94.2418% (minimum 95%, Enhanced); cerebral cortex: 95.7115% (minimum 99%, Missing); choroid plexus: 92.4670% (minimum 99%, Missing); colon: 83.6457% (minimum 97%, Missing); duodenum: 89.2727% (minimum 99%, Missing); esophagus: 77.3228% (minimum 97%, Missing); heart muscle: 93.8815% (minimum 95%, Enhanced); hippocampal formation: 96.6535% (minimum 99%, Missing); hypothalamus: 96.6535% (minimum 99%, Missing); kidney: 94.9710% (minimum 99%, Missing); liver: 93.5238% (minimum 95%, Enhanced); lung: 88.6282% (minimum 95%, Enhanced); lymph node: 55.7321% (minimum 97%, Missing); midbrain: 96.4637% (minimum 99%, Missing); pituitary gland: 95.1550% (minimum 99%, Missing); rectum: 82.9392% (minimum 97%, Missing); retina: 96.6535% (minimum 99%, Missing); salivary gland: 93.1689% (minimum 97%, Missing); skeletal muscle: 96.8442% (minimum 99%, Missing); skin: 90.0917% (minimum 95%, Missing); small intestine: 79.7078% (minimum 99%, Missing); smooth muscle: 89.1107% (minimum 95%, Enhanced); spinal cord: 96.4637% (minimum 99%, Missing); spleen: 69.5467% (minimum 95%, Missing); stomach: 90.7579% (minimum 97%, Missing); thymus: 49.4461% (minimum 95%, Missing); tongue: 93.8815% (minimum 97%, Missing); urinary bladder: 91.9476% (minimum 97%, Missing)",-0.455539,-0.412679,-0.520593,0,6,partial,55.5,39,50.2,"bone marrow: 55.5 nTPM (vital, limit 1); thymus: 50.2 nTPM (manageable, limit 5); lymph node: 39 nTPM (protected, limit 2); spleen: 21.5 nTPM (manageable, limit 5); esophagus: 14.4 nTPM (protected, limit 2); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 6); duodenum: 5.9 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 2); urinary bladder: 4.3 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 2 / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / extracellular matrix; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000013810,TACC3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.9407% (minimum 75%, Missing); lymph node: 55.7321% (minimum 70%, Missing); thymus: 49.4461% (minimum 65%, Missing)",-0.155539,-0.142679,-0.280593,0,6,partial,55.5,39,50.2,"bone marrow: 55.5 nTPM (vital, limit 1); thymus: 50.2 nTPM (manageable, limit 5); lymph node: 39 nTPM (protected, limit 2); spleen: 21.5 nTPM (manageable, limit 5); esophagus: 14.4 nTPM (protected, limit 2); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 6); duodenum: 5.9 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 2); urinary bladder: 4.3 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 2 / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / extracellular matrix; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000013810,TACC3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.9407% (minimum 75%, Missing); lymph node: 55.7321% (minimum 70%, Missing); thymus: 49.4461% (minimum 65%, Missing)",-0.155539,-0.142679,-0.280593,0,6,partial,55.5,39,50.2,"bone marrow: 55.5 nTPM (vital, limit 1); thymus: 50.2 nTPM (manageable, limit 5); lymph node: 39 nTPM (protected, limit 3); spleen: 21.5 nTPM (manageable, limit 5); esophagus: 14.4 nTPM (protected, limit 3); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); lung: 6.3 nTPM (vital, limit 6); duodenum: 5.9 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 3); urinary bladder: 4.3 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 2 / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / extracellular matrix; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000013810,TACC3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.9407% (minimum 75%, Missing); lymph node: 55.7321% (minimum 70%, Missing); thymus: 49.4461% (minimum 65%, Missing)",-0.155539,-0.142679,-0.280593,0,6,partial,55.5,39,50.2,"bone marrow: 55.5 nTPM (vital, limit 1); thymus: 50.2 nTPM (manageable, limit 5); lymph node: 39 nTPM (protected, limit 3); spleen: 21.5 nTPM (manageable, limit 5); esophagus: 14.4 nTPM (protected, limit 3); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); lung: 6.3 nTPM (vital, limit 6); duodenum: 5.9 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 3); urinary bladder: 4.3 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 2 / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / extracellular matrix; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000013810,TACC3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.9407% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.7321% (minimum 70%, Baseline (adaptation disabled)); thymus: 49.4461% (minimum 65%, Baseline (adaptation disabled))",-0.155539,-0.142679,-0.280593,0,6,partial,55.5,39,50.2,"bone marrow: 55.5 nTPM (vital, limit 1); thymus: 50.2 nTPM (manageable, limit 5); lymph node: 39 nTPM (protected, limit 3); spleen: 21.5 nTPM (manageable, limit 5); esophagus: 14.4 nTPM (protected, limit 3); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); lung: 6.3 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 3); urinary bladder: 4.3 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); liver: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); cerebellum: 3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 2 / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / extracellular matrix; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000013810,TACC3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7168% (minimum 95%, Missing); adrenal gland: 60.5042% (minimum 99%, Missing); amygdala: 64.8649% (minimum 99%, Missing); basal ganglia: 62.6087% (minimum 99%, Missing); bone marrow: 59.0164% (minimum 99%, Missing); cerebellum: 61.0169% (minimum 99%, Missing); cerebral cortex: 54.5455% (minimum 99%, Missing); choroid plexus: 67.9245% (minimum 99%, Missing); colon: 54.5455% (minimum 97%, Missing); duodenum: 53.3333% (minimum 99%, Missing); esophagus: 51.4286% (minimum 97%, Missing); heart muscle: 61.0169% (minimum 99%, Missing); hippocampal formation: 64.8649% (minimum 99%, Missing); hypothalamus: 64.8649% (minimum 99%, Missing); kidney: 61.0169% (minimum 99%, Missing); liver: 58.5366% (minimum 99%, Missing); lung: 62.6087% (minimum 99%, Missing); lymph node: 52.9412% (minimum 97%, Missing); midbrain: 65.4545% (minimum 99%, Missing); pancreas: 56.6929% (minimum 99%, Missing); parathyroid gland: 51.0638% (minimum 97%, Missing); pituitary gland: 61.5385% (minimum 99%, Missing); rectum: 57.1429% (minimum 97%, Missing); retina: 60.5042% (minimum 99%, Missing); salivary gland: 56.2500% (minimum 97%, Missing); skeletal muscle: 59.0164% (minimum 99%, Missing); skin: 40.2235% (minimum 95%, Missing); small intestine: 56.2500% (minimum 99%, Missing); smooth muscle: 57.6000% (minimum 99%, Missing); spinal cord: 66.0550% (minimum 99%, Missing); spleen: 57.1429% (minimum 95%, Missing); stomach: 55.8140% (minimum 97%, Missing); thymus: 50.3497% (minimum 95%, Missing); thyroid gland: 52.1739% (minimum 95%, Missing); tongue: 62.6087% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",-0.547765,-0.459362,-0.456667,0,80,unavailable,6.3,6.9,10.7,"skin: 10.7 nTPM (manageable, limit 5); thymus: 7.1 nTPM (manageable, limit 5); parathyroid gland: 6.9 nTPM (protected, limit 2); esophagus: 6.8 nTPM (protected, limit 2); thyroid gland: 6.6 nTPM (manageable, limit 5); lymph node: 6.4 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); stomach: 5.7 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5.4 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000020256,ZFP64,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7168% (minimum 65%, Missing); adrenal gland: 60.5042% (minimum 75%, Missing); amygdala: 64.8649% (minimum 75%, Missing); basal ganglia: 62.6087% (minimum 75%, Missing); bone marrow: 59.0164% (minimum 75%, Missing); cerebellum: 61.0169% (minimum 75%, Missing); cerebral cortex: 54.5455% (minimum 75%, Missing); choroid plexus: 67.9245% (minimum 75%, Missing); colon: 54.5455% (minimum 70%, Missing); duodenum: 53.3333% (minimum 75%, Missing); esophagus: 51.4286% (minimum 70%, Missing); heart muscle: 61.0169% (minimum 75%, Missing); hippocampal formation: 64.8649% (minimum 75%, Missing); hypothalamus: 64.8649% (minimum 75%, Missing); kidney: 61.0169% (minimum 75%, Missing); liver: 58.5366% (minimum 75%, Missing); lung: 62.6087% (minimum 75%, Missing); lymph node: 52.9412% (minimum 70%, Missing); midbrain: 65.4545% (minimum 75%, Missing); pancreas: 56.6929% (minimum 75%, Missing); parathyroid gland: 51.0638% (minimum 70%, Missing); pituitary gland: 61.5385% (minimum 75%, Missing); rectum: 57.1429% (minimum 70%, Missing); retina: 60.5042% (minimum 75%, Missing); salivary gland: 56.2500% (minimum 70%, Missing); skeletal muscle: 59.0164% (minimum 75%, Missing); skin: 40.2235% (minimum 65%, Missing); small intestine: 56.2500% (minimum 75%, Missing); smooth muscle: 57.6000% (minimum 75%, Missing); spinal cord: 66.0550% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 55.8140% (minimum 70%, Missing); thymus: 50.3497% (minimum 65%, Missing); thyroid gland: 52.1739% (minimum 65%, Missing); tongue: 62.6087% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.247765,-0.189362,-0.216667,0,80,unavailable,6.3,6.9,10.7,"skin: 10.7 nTPM (manageable, limit 5); thymus: 7.1 nTPM (manageable, limit 5); parathyroid gland: 6.9 nTPM (protected, limit 2); esophagus: 6.8 nTPM (protected, limit 2); thyroid gland: 6.6 nTPM (manageable, limit 5); lymph node: 6.4 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); stomach: 5.7 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5.4 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000020256,ZFP64,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7168% (minimum 65%, Missing); adrenal gland: 60.5042% (minimum 75%, Missing); amygdala: 64.8649% (minimum 75%, Missing); basal ganglia: 62.6087% (minimum 75%, Missing); bone marrow: 59.0164% (minimum 75%, Missing); cerebellum: 61.0169% (minimum 75%, Missing); cerebral cortex: 54.5455% (minimum 75%, Missing); choroid plexus: 67.9245% (minimum 75%, Missing); colon: 54.5455% (minimum 70%, Missing); duodenum: 53.3333% (minimum 75%, Missing); esophagus: 51.4286% (minimum 70%, Missing); heart muscle: 61.0169% (minimum 75%, Missing); hippocampal formation: 64.8649% (minimum 75%, Missing); hypothalamus: 64.8649% (minimum 75%, Missing); kidney: 61.0169% (minimum 75%, Missing); liver: 58.5366% (minimum 75%, Missing); lung: 62.6087% (minimum 75%, Missing); lymph node: 52.9412% (minimum 70%, Missing); midbrain: 65.4545% (minimum 75%, Missing); pancreas: 56.6929% (minimum 75%, Missing); parathyroid gland: 51.0638% (minimum 70%, Missing); pituitary gland: 61.5385% (minimum 75%, Missing); rectum: 57.1429% (minimum 70%, Missing); retina: 60.5042% (minimum 75%, Missing); salivary gland: 56.2500% (minimum 70%, Missing); skeletal muscle: 59.0164% (minimum 75%, Missing); skin: 40.2235% (minimum 65%, Missing); small intestine: 56.2500% (minimum 75%, Missing); smooth muscle: 57.6000% (minimum 75%, Missing); spinal cord: 66.0550% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 55.8140% (minimum 70%, Missing); thymus: 50.3497% (minimum 65%, Missing); thyroid gland: 52.1739% (minimum 65%, Missing); tongue: 62.6087% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.247765,-0.189362,-0.216667,0,80,unavailable,6.3,6.9,10.7,"skin: 10.7 nTPM (manageable, limit 5); thymus: 7.1 nTPM (manageable, limit 5); parathyroid gland: 6.9 nTPM (protected, limit 3); esophagus: 6.8 nTPM (protected, limit 3); thyroid gland: 6.6 nTPM (manageable, limit 5); lymph node: 6.4 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); stomach: 5.7 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5.4 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000020256,ZFP64,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7168% (minimum 65%, Missing); adrenal gland: 60.5042% (minimum 75%, Missing); amygdala: 64.8649% (minimum 75%, Missing); basal ganglia: 62.6087% (minimum 75%, Missing); bone marrow: 59.0164% (minimum 75%, Missing); cerebellum: 61.0169% (minimum 75%, Missing); cerebral cortex: 54.5455% (minimum 75%, Missing); choroid plexus: 67.9245% (minimum 75%, Missing); colon: 54.5455% (minimum 70%, Missing); duodenum: 53.3333% (minimum 75%, Missing); esophagus: 51.4286% (minimum 70%, Missing); heart muscle: 61.0169% (minimum 75%, Missing); hippocampal formation: 64.8649% (minimum 75%, Missing); hypothalamus: 64.8649% (minimum 75%, Missing); kidney: 61.0169% (minimum 75%, Missing); liver: 58.5366% (minimum 75%, Missing); lung: 62.6087% (minimum 75%, Missing); lymph node: 52.9412% (minimum 70%, Missing); midbrain: 65.4545% (minimum 75%, Missing); pancreas: 56.6929% (minimum 75%, Missing); parathyroid gland: 51.0638% (minimum 70%, Missing); pituitary gland: 61.5385% (minimum 75%, Missing); rectum: 57.1429% (minimum 70%, Missing); retina: 60.5042% (minimum 75%, Missing); salivary gland: 56.2500% (minimum 70%, Missing); skeletal muscle: 59.0164% (minimum 75%, Missing); skin: 40.2235% (minimum 65%, Missing); small intestine: 56.2500% (minimum 75%, Missing); smooth muscle: 57.6000% (minimum 75%, Missing); spinal cord: 66.0550% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 55.8140% (minimum 70%, Missing); thymus: 50.3497% (minimum 65%, Missing); thyroid gland: 52.1739% (minimum 65%, Missing); tongue: 62.6087% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.247765,-0.189362,-0.216667,0,80,unavailable,6.3,6.9,10.7,"skin: 10.7 nTPM (manageable, limit 5); thymus: 7.1 nTPM (manageable, limit 5); parathyroid gland: 6.9 nTPM (protected, limit 3); esophagus: 6.8 nTPM (protected, limit 3); thyroid gland: 6.6 nTPM (manageable, limit 5); lymph node: 6.4 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); stomach: 5.7 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5.4 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000020256,ZFP64,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7168% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.5042% (minimum 75%, Baseline (adaptation disabled)); amygdala: 64.8649% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.6087% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 59.0164% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.0169% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 54.5455% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.9245% (minimum 75%, Baseline (adaptation disabled)); colon: 54.5455% (minimum 70%, Baseline (adaptation disabled)); duodenum: 53.3333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 51.4286% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 61.0169% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.8649% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.8649% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.0169% (minimum 75%, Baseline (adaptation disabled)); liver: 58.5366% (minimum 75%, Baseline (adaptation disabled)); lung: 62.6087% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.9412% (minimum 70%, Baseline (adaptation disabled)); midbrain: 65.4545% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.6929% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.0638% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 61.5385% (minimum 75%, Baseline (adaptation disabled)); rectum: 57.1429% (minimum 70%, Baseline (adaptation disabled)); retina: 60.5042% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.2500% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 59.0164% (minimum 75%, Baseline (adaptation disabled)); skin: 40.2235% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.2500% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.6000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.0550% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.1429% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.8140% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.3497% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.1739% (minimum 65%, Baseline (adaptation disabled)); tongue: 62.6087% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 70%, Baseline (adaptation disabled))",-0.247765,-0.189362,-0.216667,0,80,unavailable,6.3,6.9,10.7,"skin: 10.7 nTPM (manageable, limit 5); thymus: 7.1 nTPM (manageable, limit 5); parathyroid gland: 6.9 nTPM (protected, limit 3); esophagus: 6.8 nTPM (protected, limit 3); thyroid gland: 6.6 nTPM (manageable, limit 5); lymph node: 6.4 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); stomach: 5.7 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5.4 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000020256,ZFP64,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2258% (minimum 95%, Missing); adrenal gland: 62.8205% (minimum 99%, Missing); amygdala: 55.3672% (minimum 99%, Missing); basal ganglia: 57.9882% (minimum 99%, Missing); bone marrow: 49.2462% (minimum 99%, Missing); cerebellum: 55.3672% (minimum 99%, Missing); cerebral cortex: 42.9825% (minimum 99%, Missing); choroid plexus: 85.2174% (minimum 99%, Missing); colon: 58.6826% (minimum 97%, Missing); duodenum: 57.3099% (minimum 99%, Missing); esophagus: 58.6826% (minimum 97%, Missing); heart muscle: 71.5328% (minimum 99%, Missing); hippocampal formation: 52.6882% (minimum 99%, Missing); hypothalamus: 54.7486% (minimum 99%, Missing); kidney: 63.2258% (minimum 99%, Missing); liver: 51.3089% (minimum 99%, Missing); lung: 61.6352% (minimum 99%, Missing); lymph node: 50.2564% (minimum 97%, Missing); midbrain: 51.3089% (minimum 99%, Missing); pancreas: 64.9007% (minimum 99%, Missing); parathyroid gland: 62.0253% (minimum 97%, Missing); pituitary gland: 70.0000% (minimum 99%, Missing); rectum: 57.3099% (minimum 97%, Missing); retina: 57.9882% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 56.3218% (minimum 99%, Missing); skin: 57.6471% (minimum 95%, Missing); small intestine: 55.3672% (minimum 99%, Missing); smooth muscle: 57.9882% (minimum 99%, Missing); spinal cord: 43.7500% (minimum 99%, Missing); spleen: 58.6826% (minimum 95%, Missing); stomach: 60.8696% (minimum 97%, Missing); thymus: 41.7021% (minimum 95%, Missing); thyroid gland: 53.5519% (minimum 95%, Missing); tongue: 50.5155% (minimum 97%, Missing); urinary bladder: 57.6471% (minimum 97%, Missing)",-0.532979,-0.467436,-0.560175,0,3,partial,13,9.7,13.7,"thymus: 13.7 nTPM (manageable, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 2); tongue: 9.6 nTPM (protected, limit 2); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 2); basal ganglia: 7.1 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 2); esophagus: 6.9 nTPM (protected, limit 2); spleen: 6.9 nTPM (manageable, limit 5); stomach: 6.3 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 2); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 5.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000021574,SPAST,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2258% (minimum 65%, Missing); adrenal gland: 62.8205% (minimum 75%, Missing); amygdala: 55.3672% (minimum 75%, Missing); basal ganglia: 57.9882% (minimum 75%, Missing); bone marrow: 49.2462% (minimum 75%, Missing); cerebellum: 55.3672% (minimum 75%, Missing); cerebral cortex: 42.9825% (minimum 75%, Missing); colon: 58.6826% (minimum 70%, Missing); duodenum: 57.3099% (minimum 75%, Missing); esophagus: 58.6826% (minimum 70%, Missing); heart muscle: 71.5328% (minimum 75%, Missing); hippocampal formation: 52.6882% (minimum 75%, Missing); hypothalamus: 54.7486% (minimum 75%, Missing); kidney: 63.2258% (minimum 75%, Missing); liver: 51.3089% (minimum 75%, Missing); lung: 61.6352% (minimum 75%, Missing); lymph node: 50.2564% (minimum 70%, Missing); midbrain: 51.3089% (minimum 75%, Missing); pancreas: 64.9007% (minimum 75%, Missing); parathyroid gland: 62.0253% (minimum 70%, Missing); pituitary gland: 70.0000% (minimum 75%, Missing); rectum: 57.3099% (minimum 70%, Missing); retina: 57.9882% (minimum 75%, Missing); skeletal muscle: 56.3218% (minimum 75%, Missing); skin: 57.6471% (minimum 65%, Missing); small intestine: 55.3672% (minimum 75%, Missing); smooth muscle: 57.9882% (minimum 75%, Missing); spinal cord: 43.7500% (minimum 75%, Missing); spleen: 58.6826% (minimum 65%, Missing); stomach: 60.8696% (minimum 70%, Missing); thymus: 41.7021% (minimum 65%, Missing); thyroid gland: 53.5519% (minimum 65%, Missing); tongue: 50.5155% (minimum 70%, Missing); urinary bladder: 57.6471% (minimum 70%, Missing)",-0.232979,-0.197436,-0.320175,0,3,partial,13,9.7,13.7,"thymus: 13.7 nTPM (manageable, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 2); tongue: 9.6 nTPM (protected, limit 2); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 2); basal ganglia: 7.1 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 2); esophagus: 6.9 nTPM (protected, limit 2); spleen: 6.9 nTPM (manageable, limit 5); stomach: 6.3 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 2); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 5.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000021574,SPAST,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2258% (minimum 65%, Missing); adrenal gland: 62.8205% (minimum 75%, Missing); amygdala: 55.3672% (minimum 75%, Missing); basal ganglia: 57.9882% (minimum 75%, Missing); bone marrow: 49.2462% (minimum 75%, Missing); cerebellum: 55.3672% (minimum 75%, Missing); cerebral cortex: 42.9825% (minimum 75%, Missing); colon: 58.6826% (minimum 70%, Missing); duodenum: 57.3099% (minimum 75%, Missing); esophagus: 58.6826% (minimum 70%, Missing); heart muscle: 71.5328% (minimum 75%, Missing); hippocampal formation: 52.6882% (minimum 75%, Missing); hypothalamus: 54.7486% (minimum 75%, Missing); kidney: 63.2258% (minimum 75%, Missing); liver: 51.3089% (minimum 75%, Missing); lung: 61.6352% (minimum 75%, Missing); lymph node: 50.2564% (minimum 70%, Missing); midbrain: 51.3089% (minimum 75%, Missing); pancreas: 64.9007% (minimum 75%, Missing); parathyroid gland: 62.0253% (minimum 70%, Missing); pituitary gland: 70.0000% (minimum 75%, Missing); rectum: 57.3099% (minimum 70%, Missing); retina: 57.9882% (minimum 75%, Missing); skeletal muscle: 56.3218% (minimum 75%, Missing); skin: 57.6471% (minimum 65%, Missing); small intestine: 55.3672% (minimum 75%, Missing); smooth muscle: 57.9882% (minimum 75%, Missing); spinal cord: 43.7500% (minimum 75%, Missing); spleen: 58.6826% (minimum 65%, Missing); stomach: 60.8696% (minimum 70%, Missing); thymus: 41.7021% (minimum 65%, Missing); thyroid gland: 53.5519% (minimum 65%, Missing); tongue: 50.5155% (minimum 70%, Missing); urinary bladder: 57.6471% (minimum 70%, Missing)",-0.232979,-0.197436,-0.320175,0,3,partial,13,9.7,13.7,"thymus: 13.7 nTPM (manageable, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 3); tongue: 9.6 nTPM (protected, limit 3); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 3); basal ganglia: 7.1 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 3); esophagus: 6.9 nTPM (protected, limit 3); spleen: 6.9 nTPM (manageable, limit 5); stomach: 6.3 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 3); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 5.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000021574,SPAST,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2258% (minimum 65%, Missing); adrenal gland: 62.8205% (minimum 75%, Missing); amygdala: 55.3672% (minimum 75%, Missing); basal ganglia: 57.9882% (minimum 75%, Missing); bone marrow: 49.2462% (minimum 75%, Missing); cerebellum: 55.3672% (minimum 75%, Missing); cerebral cortex: 42.9825% (minimum 75%, Missing); colon: 58.6826% (minimum 70%, Missing); duodenum: 57.3099% (minimum 75%, Missing); esophagus: 58.6826% (minimum 70%, Missing); heart muscle: 71.5328% (minimum 75%, Missing); hippocampal formation: 52.6882% (minimum 75%, Missing); hypothalamus: 54.7486% (minimum 75%, Missing); kidney: 63.2258% (minimum 75%, Missing); liver: 51.3089% (minimum 75%, Missing); lung: 61.6352% (minimum 75%, Missing); lymph node: 50.2564% (minimum 70%, Missing); midbrain: 51.3089% (minimum 75%, Missing); pancreas: 64.9007% (minimum 75%, Missing); parathyroid gland: 62.0253% (minimum 70%, Missing); pituitary gland: 70.0000% (minimum 75%, Missing); rectum: 57.3099% (minimum 70%, Missing); retina: 57.9882% (minimum 75%, Missing); skeletal muscle: 56.3218% (minimum 75%, Missing); skin: 57.6471% (minimum 65%, Missing); small intestine: 55.3672% (minimum 75%, Missing); smooth muscle: 57.9882% (minimum 75%, Missing); spinal cord: 43.7500% (minimum 75%, Missing); spleen: 58.6826% (minimum 65%, Missing); stomach: 60.8696% (minimum 70%, Missing); thymus: 41.7021% (minimum 65%, Missing); thyroid gland: 53.5519% (minimum 65%, Missing); tongue: 50.5155% (minimum 70%, Missing); urinary bladder: 57.6471% (minimum 70%, Missing)",-0.232979,-0.197436,-0.320175,0,3,partial,13,9.7,13.7,"thymus: 13.7 nTPM (manageable, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 3); tongue: 9.6 nTPM (protected, limit 3); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 3); basal ganglia: 7.1 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 3); esophagus: 6.9 nTPM (protected, limit 3); spleen: 6.9 nTPM (manageable, limit 5); stomach: 6.3 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 3); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 5.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000021574,SPAST,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2258% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.8205% (minimum 75%, Baseline (adaptation disabled)); amygdala: 55.3672% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 57.9882% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 49.2462% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.3672% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 42.9825% (minimum 75%, Baseline (adaptation disabled)); colon: 58.6826% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.3099% (minimum 75%, Baseline (adaptation disabled)); esophagus: 58.6826% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 71.5328% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 52.6882% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 54.7486% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.2258% (minimum 75%, Baseline (adaptation disabled)); liver: 51.3089% (minimum 75%, Baseline (adaptation disabled)); lung: 61.6352% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.2564% (minimum 70%, Baseline (adaptation disabled)); midbrain: 51.3089% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.9007% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.0253% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.0000% (minimum 75%, Baseline (adaptation disabled)); rectum: 57.3099% (minimum 70%, Baseline (adaptation disabled)); retina: 57.9882% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 56.3218% (minimum 75%, Baseline (adaptation disabled)); skin: 57.6471% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.3672% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.9882% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 43.7500% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.6826% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.8696% (minimum 70%, Baseline (adaptation disabled)); thymus: 41.7021% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.5519% (minimum 65%, Baseline (adaptation disabled)); tongue: 50.5155% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.6471% (minimum 70%, Baseline (adaptation disabled))",-0.232979,-0.197436,-0.320175,0,3,partial,13,9.7,13.7,"thymus: 13.7 nTPM (manageable, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 3); tongue: 9.6 nTPM (protected, limit 3); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 3); basal ganglia: 7.1 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 3); esophagus: 6.9 nTPM (protected, limit 3); spleen: 6.9 nTPM (manageable, limit 5); stomach: 6.3 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 3); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 5.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000021574,SPAST,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4173% (minimum 98%, Approved); cerebral cortex: 97.5000% (minimum 99%, Missing); colon: 73.5849% (minimum 97%, Missing); duodenum: 76.4706% (minimum 99%, Missing); esophagus: 77.2277% (minimum 97%, Missing); liver: 95.1220% (minimum 98%, Approved); lung: 97.5000% (minimum 98%, Approved); lymph node: 62.4000% (minimum 95%, Approved); rectum: 69.6429% (minimum 97%, Missing); skin: 83.8710% (minimum 95%, Missing); small intestine: 77.2277% (minimum 99%, Missing); smooth muscle: 84.7826% (minimum 99%, Missing); spleen: 93.9759% (minimum 95%, Missing); stomach: 86.6667% (minimum 97%, Missing); thymus: 49.6815% (minimum 95%, Missing); urinary bladder: 89.6552% (minimum 97%, Missing)",-0.453185,-0.326,-0.365827,0,6,partial,4.9,4.7,7.9,"thymus: 7.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 2); lymph node: 4.7 nTPM (protected, limit 4); rectum: 3.4 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000024526,DEPDC1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4173% (minimum 70%, Approved); lymph node: 62.4000% (minimum 65%, Approved); rectum: 69.6429% (minimum 70%, Missing); thymus: 49.6815% (minimum 65%, Missing)",-0.153185,-0.026,-0.0858268,0,6,partial,4.9,4.7,7.9,"thymus: 7.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 2); lymph node: 4.7 nTPM (protected, limit 4); rectum: 3.4 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000024526,DEPDC1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4173% (minimum 70%, Approved); lymph node: 62.4000% (minimum 65%, Approved); rectum: 69.6429% (minimum 70%, Missing); thymus: 49.6815% (minimum 65%, Missing)",-0.153185,-0.026,-0.0858268,0,6,partial,4.9,4.7,7.9,"thymus: 7.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 2); lymph node: 4.7 nTPM (protected, limit 4); rectum: 3.4 nTPM (protected, limit 3); duodenum: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000024526,DEPDC1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4173% (minimum 70%, Approved); lymph node: 62.4000% (minimum 65%, Approved); rectum: 69.6429% (minimum 70%, Missing); thymus: 49.6815% (minimum 65%, Missing)",-0.153185,-0.026,-0.0858268,0,6,partial,4.9,4.7,7.9,"thymus: 7.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 2); lymph node: 4.7 nTPM (protected, limit 4); rectum: 3.4 nTPM (protected, limit 3); duodenum: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000024526,DEPDC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4173% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.4000% (minimum 70%, Baseline (adaptation disabled)); rectum: 69.6429% (minimum 70%, Baseline (adaptation disabled)); thymus: 49.6815% (minimum 65%, Baseline (adaptation disabled))",-0.153185,-0.076,-0.135827,0,6,partial,4.9,4.7,7.9,"thymus: 7.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); duodenum: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000024526,DEPDC1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 90%, Approved); adrenal gland: 71.4563% (minimum 98%, Approved); amygdala: 81.2362% (minimum 99%, Missing); basal ganglia: 80.8791% (minimum 99%, Missing); bone marrow: 55.7576% (minimum 98%, Approved); cerebellum: 67.2761% (minimum 98%, Approved); cerebral cortex: 76.1905% (minimum 98%, Approved); choroid plexus: 69.5652% (minimum 99%, Missing); colon: 76.6667% (minimum 95%, Approved); duodenum: 84.5977% (minimum 98%, Approved); esophagus: 82.1429% (minimum 95%, Approved); heart muscle: 62.1622% (minimum 98%, Approved); hippocampal formation: 80.5252% (minimum 99%, Missing); hypothalamus: 76.8267% (minimum 99%, Missing); kidney: 84.9885% (minimum 98%, Approved); liver: 87.4109% (minimum 98%, Approved); lung: 81.2362% (minimum 98%, Approved); lymph node: 74.7967% (minimum 95%, Approved); midbrain: 81.4159% (minimum 99%, Missing); pancreas: 85.5814% (minimum 98%, Approved); parathyroid gland: 73.0159% (minimum 95%, Approved); pituitary gland: 78.1316% (minimum 99%, Missing); rectum: 84.5977% (minimum 95%, Approved); retina: 46.0576% (minimum 99%, Missing); salivary gland: 81.7778% (minimum 95%, Approved); skeletal muscle: 44.0191% (minimum 98%, Approved); skin: 74.7967% (minimum 90%, Approved); small intestine: 80.7018% (minimum 98%, Approved); smooth muscle: 73.1610% (minimum 98%, Approved); spinal cord: 81.0573% (minimum 99%, Missing); spleen: 80.3493% (minimum 90%, Approved); stomach: 80.1743% (minimum 95%, Approved); thymus: 67.8967% (minimum 95%, Missing); thyroid gland: 81.0573% (minimum 90%, Approved); tongue: 37.3604% (minimum 97%, Missing); urinary bladder: 79.8265% (minimum 95%, Approved)",-0.271033,-0.596396,-0.539809,0,5,partial,46.8,61.7,17.4,"tongue: 61.7 nTPM (protected, limit 2); skeletal muscle: 46.8 nTPM (vital, limit 2); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 2); heart muscle: 22.4 nTPM (vital, limit 2); cerebellum: 17.9 nTPM (vital, limit 2); thymus: 17.4 nTPM (manageable, limit 5); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 2); parathyroid gland: 13.6 nTPM (protected, limit 4); smooth muscle: 13.5 nTPM (vital, limit 2); skin: 12.4 nTPM (manageable, limit 10); lymph node: 12.4 nTPM (protected, limit 4); cerebral cortex: 11.5 nTPM (vital, limit 2); colon: 11.2 nTPM (protected, limit 4); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 4); stomach: 9.1 nTPM (protected, limit 4); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 2); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.4 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 4); esophagus: 8 nTPM (protected, limit 4); duodenum: 6.7 nTPM (vital, limit 2); rectum: 6.7 nTPM (protected, limit 4); kidney: 6.5 nTPM (vital, limit 2); pancreas: 6.2 nTPM (vital, limit 2); liver: 5.3 nTPM (vital, limit 2)",,64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000025156,HSF2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.7576% (minimum 70%, Approved); cerebellum: 67.2761% (minimum 70%, Approved); choroid plexus: 69.5652% (minimum 75%, Missing); heart muscle: 62.1622% (minimum 70%, Approved); retina: 46.0576% (minimum 75%, Missing); skeletal muscle: 44.0191% (minimum 70%, Approved); tongue: 37.3604% (minimum 70%, Missing)",0.0289668,-0.326396,-0.289424,0,5,partial,46.8,61.7,17.4,"tongue: 61.7 nTPM (protected, limit 2); skeletal muscle: 46.8 nTPM (vital, limit 2); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 2); heart muscle: 22.4 nTPM (vital, limit 2); cerebellum: 17.9 nTPM (vital, limit 2); thymus: 17.4 nTPM (manageable, limit 5); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 2); parathyroid gland: 13.6 nTPM (protected, limit 4); smooth muscle: 13.5 nTPM (vital, limit 2); skin: 12.4 nTPM (manageable, limit 10); lymph node: 12.4 nTPM (protected, limit 4); cerebral cortex: 11.5 nTPM (vital, limit 2); colon: 11.2 nTPM (protected, limit 4); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 4); stomach: 9.1 nTPM (protected, limit 4); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 2); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.4 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 4); esophagus: 8 nTPM (protected, limit 4); duodenum: 6.7 nTPM (vital, limit 2); rectum: 6.7 nTPM (protected, limit 4); kidney: 6.5 nTPM (vital, limit 2); pancreas: 6.2 nTPM (vital, limit 2); liver: 5.3 nTPM (vital, limit 2)",,64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000025156,HSF2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.7576% (minimum 70%, Approved); cerebellum: 67.2761% (minimum 70%, Approved); choroid plexus: 69.5652% (minimum 75%, Missing); heart muscle: 62.1622% (minimum 70%, Approved); retina: 46.0576% (minimum 75%, Missing); skeletal muscle: 44.0191% (minimum 70%, Approved); tongue: 37.3604% (minimum 70%, Missing)",0.0289668,-0.326396,-0.289424,0,5,partial,46.8,61.7,17.4,"tongue: 61.7 nTPM (protected, limit 3); skeletal muscle: 46.8 nTPM (vital, limit 2); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 2); heart muscle: 22.4 nTPM (vital, limit 2); cerebellum: 17.9 nTPM (vital, limit 2); thymus: 17.4 nTPM (manageable, limit 5); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 2); parathyroid gland: 13.6 nTPM (protected, limit 4); smooth muscle: 13.5 nTPM (vital, limit 2); skin: 12.4 nTPM (manageable, limit 10); lymph node: 12.4 nTPM (protected, limit 4); cerebral cortex: 11.5 nTPM (vital, limit 2); colon: 11.2 nTPM (protected, limit 4); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 4); stomach: 9.1 nTPM (protected, limit 4); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 2); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.4 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 4); esophagus: 8 nTPM (protected, limit 4); duodenum: 6.7 nTPM (vital, limit 2); rectum: 6.7 nTPM (protected, limit 4); kidney: 6.5 nTPM (vital, limit 2); pancreas: 6.2 nTPM (vital, limit 2); liver: 5.3 nTPM (vital, limit 2)",,64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000025156,HSF2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.7576% (minimum 70%, Approved); cerebellum: 67.2761% (minimum 70%, Approved); choroid plexus: 69.5652% (minimum 75%, Missing); heart muscle: 62.1622% (minimum 70%, Approved); retina: 46.0576% (minimum 75%, Missing); skeletal muscle: 44.0191% (minimum 70%, Approved); tongue: 37.3604% (minimum 70%, Missing)",0.0289668,-0.326396,-0.289424,0,5,partial,46.8,61.7,17.4,"tongue: 61.7 nTPM (protected, limit 3); skeletal muscle: 46.8 nTPM (vital, limit 2); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 2); heart muscle: 22.4 nTPM (vital, limit 2); cerebellum: 17.9 nTPM (vital, limit 2); thymus: 17.4 nTPM (manageable, limit 5); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 2); parathyroid gland: 13.6 nTPM (protected, limit 4); smooth muscle: 13.5 nTPM (vital, limit 2); skin: 12.4 nTPM (manageable, limit 10); lymph node: 12.4 nTPM (protected, limit 4); cerebral cortex: 11.5 nTPM (vital, limit 2); colon: 11.2 nTPM (protected, limit 4); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 4); stomach: 9.1 nTPM (protected, limit 4); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 2); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.4 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 4); esophagus: 8 nTPM (protected, limit 4); duodenum: 6.7 nTPM (vital, limit 2); rectum: 6.7 nTPM (protected, limit 4); kidney: 6.5 nTPM (vital, limit 2); pancreas: 6.2 nTPM (vital, limit 2); liver: 5.3 nTPM (vital, limit 2)",,64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000025156,HSF2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4563% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 55.7576% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.2761% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.5652% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 62.1622% (minimum 75%, Baseline (adaptation disabled)); retina: 46.0576% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 44.0191% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.1610% (minimum 75%, Baseline (adaptation disabled)); tongue: 37.3604% (minimum 70%, Baseline (adaptation disabled))",0.0289668,-0.326396,-0.309809,0,5,partial,46.8,61.7,17.4,"tongue: 61.7 nTPM (protected, limit 3); skeletal muscle: 46.8 nTPM (vital, limit 1); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); heart muscle: 22.4 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 3); smooth muscle: 13.5 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 3); skin: 12.4 nTPM (manageable, limit 5); cerebral cortex: 11.5 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 3); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 3); adipose tissue: 9.2 nTPM (manageable, limit 5); stomach: 9.1 nTPM (protected, limit 3); spleen: 9 nTPM (manageable, limit 5); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); thyroid gland: 8.6 nTPM (manageable, limit 5); amygdala: 8.5 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); midbrain: 8.4 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 3); esophagus: 8 nTPM (protected, limit 3); duodenum: 6.7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); kidney: 6.5 nTPM (vital, limit 1); pancreas: 6.2 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1)",,64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000025156,HSF2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.1667% (minimum 95%, Missing); adrenal gland: 59.3750% (minimum 99%, Missing); basal ganglia: 86.3636% (minimum 99%, Missing); cerebellum: 73.0769% (minimum 99%, Missing); cerebral cortex: 90.4762% (minimum 99%, Missing); choroid plexus: 95.0000% (minimum 99%, Missing); colon: 95.0000% (minimum 97%, Missing); heart muscle: 90.4762% (minimum 99%, Missing); hypothalamus: 79.1667% (minimum 99%, Missing); kidney: 33.9286% (minimum 99%, Missing); midbrain: 86.3636% (minimum 99%, Missing); pancreas: 90.4762% (minimum 99%, Missing); pituitary gland: 79.1667% (minimum 99%, Missing); retina: 90.4762% (minimum 99%, Missing); salivary gland: 95.0000% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); stomach: 52.7778% (minimum 97%, Missing); thymus: 86.3636% (minimum 95%, Missing)",-0.158333,-0.442222,-0.650714,0,80,unavailable,3.7,1.7,0.5,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000027644,INSRR,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 59.3750% (minimum 75%, Missing); cerebellum: 73.0769% (minimum 75%, Missing); kidney: 33.9286% (minimum 75%, Missing); stomach: 52.7778% (minimum 70%, Missing)",0.141667,-0.172222,-0.410714,0,80,unavailable,3.7,1.7,0.5,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000027644,INSRR,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 59.3750% (minimum 75%, Missing); cerebellum: 73.0769% (minimum 75%, Missing); kidney: 33.9286% (minimum 75%, Missing); stomach: 52.7778% (minimum 70%, Missing)",0.141667,-0.172222,-0.410714,0,80,unavailable,3.7,1.7,0.5,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000027644,INSRR,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 59.3750% (minimum 75%, Missing); cerebellum: 73.0769% (minimum 75%, Missing); kidney: 33.9286% (minimum 75%, Missing); stomach: 52.7778% (minimum 70%, Missing)",0.141667,-0.172222,-0.410714,0,80,unavailable,3.7,1.7,0.5,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000027644,INSRR,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 59.3750% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.0769% (minimum 75%, Baseline (adaptation disabled)); kidney: 33.9286% (minimum 75%, Baseline (adaptation disabled)); stomach: 52.7778% (minimum 70%, Baseline (adaptation disabled))",0.141667,-0.172222,-0.410714,0,80,unavailable,3.7,1.7,0.5,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000027644,INSRR,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.4000% (minimum 99%, Missing); basal ganglia: 98.4000% (minimum 99%, Missing); bone marrow: 52.7897% (minimum 99%, Missing); cerebral cortex: 93.8931% (minimum 99%, Missing); choroid plexus: 97.6190% (minimum 99%, Missing); colon: 75.9259% (minimum 97%, Missing); duodenum: 67.5824% (minimum 99%, Missing); esophagus: 83.6735% (minimum 97%, Missing); hippocampal formation: 97.6190% (minimum 99%, Missing); hypothalamus: 97.6190% (minimum 99%, Missing); kidney: 81.4570% (minimum 99%, Missing); liver: 97.6190% (minimum 98%, Approved); lung: 97.6190% (minimum 99%, Missing); lymph node: 58.2938% (minimum 97%, Missing); midbrain: 96.0938% (minimum 99%, Missing); rectum: 69.4915% (minimum 97%, Missing); skin: 86.0140% (minimum 90%, Approved); small intestine: 66.4865% (minimum 99%, Missing); smooth muscle: 93.8931% (minimum 99%, Missing); spinal cord: 88.4892% (minimum 99%, Missing); spleen: 89.1304% (minimum 95%, Missing); stomach: 90.4412% (minimum 95%, Approved); thymus: 37.8462% (minimum 95%, Missing); thyroid gland: 91.1111% (minimum 95%, Missing); urinary bladder: 92.4812% (minimum 97%, Missing)",-0.571538,-0.387062,-0.462103,0,2,partial,11,8.8,20.2,"thymus: 20.2 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 2); colon: 3.9 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); spinal cord: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000035499,DEPDC1B,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Jamin 2021"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 52.7897% (minimum 75%, Missing); duodenum: 67.5824% (minimum 75%, Missing); lymph node: 58.2938% (minimum 70%, Missing); rectum: 69.4915% (minimum 70%, Missing); small intestine: 66.4865% (minimum 75%, Missing); thymus: 37.8462% (minimum 65%, Missing)",-0.271538,-0.117062,-0.222103,0,2,partial,11,8.8,20.2,"thymus: 20.2 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 2); colon: 3.9 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); spinal cord: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000035499,DEPDC1B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Jamin 2021"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 52.7897% (minimum 75%, Missing); duodenum: 67.5824% (minimum 75%, Missing); lymph node: 58.2938% (minimum 70%, Missing); rectum: 69.4915% (minimum 70%, Missing); small intestine: 66.4865% (minimum 75%, Missing); thymus: 37.8462% (minimum 65%, Missing)",-0.271538,-0.117062,-0.222103,0,2,partial,11,8.8,20.2,"thymus: 20.2 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 3); colon: 3.9 nTPM (protected, limit 3); kidney: 2.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000035499,DEPDC1B,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Jamin 2021"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 52.7897% (minimum 75%, Missing); duodenum: 67.5824% (minimum 75%, Missing); lymph node: 58.2938% (minimum 70%, Missing); rectum: 69.4915% (minimum 70%, Missing); small intestine: 66.4865% (minimum 75%, Missing); thymus: 37.8462% (minimum 65%, Missing)",-0.271538,-0.117062,-0.222103,0,2,partial,11,8.8,20.2,"thymus: 20.2 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 3); colon: 3.9 nTPM (protected, limit 3); kidney: 2.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000035499,DEPDC1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Jamin 2021"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 52.7897% (minimum 75%, Baseline (adaptation disabled)); duodenum: 67.5824% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.2938% (minimum 70%, Baseline (adaptation disabled)); rectum: 69.4915% (minimum 70%, Baseline (adaptation disabled)); small intestine: 66.4865% (minimum 75%, Baseline (adaptation disabled)); thymus: 37.8462% (minimum 65%, Baseline (adaptation disabled))",-0.271538,-0.117062,-0.222103,0,2,partial,11,8.8,20.2,"thymus: 20.2 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 3); colon: 3.9 nTPM (protected, limit 3); kidney: 2.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000035499,DEPDC1B,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Jamin 2021"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 31.7647% (minimum 99%, Missing); colon: 54.0000% (minimum 97%, Missing); duodenum: 61.3636% (minimum 99%, Missing); esophagus: 79.4118% (minimum 80%, Enhanced); heart muscle: 93.1034% (minimum 95%, Enhanced); hippocampal formation: 79.4118% (minimum 99%, Missing); kidney: 23.2759% (minimum 99%, Missing); liver: 90.0000% (minimum 95%, Enhanced); lung: 65.8537% (minimum 95%, Enhanced); lymph node: 6.3529% (minimum 97%, Missing); pancreas: 90.0000% (minimum 95%, Enhanced); rectum: 55.1020% (minimum 97%, Missing); salivary gland: 67.5000% (minimum 80%, Enhanced); small intestine: 25.4717% (minimum 99%, Missing); smooth muscle: 87.0968% (minimum 95%, Enhanced); spleen: 14.6739% (minimum 95%, Missing); stomach: 55.1020% (minimum 80%, Enhanced); thymus: 30.0000% (minimum 95%, Missing); urinary bladder: 61.3636% (minimum 80%, Enhanced)",-0.803261,-0.906471,-0.757241,0,11,partial,8.9,39.8,15.7,"lymph node: 39.8 nTPM (protected, limit 2); spleen: 15.7 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); bone marrow: 5.8 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000035720,STAP1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 31.7647% (minimum 75%, Missing); colon: 54.0000% (minimum 70%, Missing); duodenum: 61.3636% (minimum 75%, Missing); kidney: 23.2759% (minimum 75%, Missing); lymph node: 6.3529% (minimum 70%, Missing); rectum: 55.1020% (minimum 70%, Missing); small intestine: 25.4717% (minimum 75%, Missing); spleen: 14.6739% (minimum 65%, Missing); thymus: 30.0000% (minimum 65%, Missing)",-0.503261,-0.636471,-0.517241,0,11,partial,8.9,39.8,15.7,"lymph node: 39.8 nTPM (protected, limit 2); spleen: 15.7 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); bone marrow: 5.8 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000035720,STAP1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 31.7647% (minimum 75%, Missing); colon: 54.0000% (minimum 70%, Missing); duodenum: 61.3636% (minimum 75%, Missing); kidney: 23.2759% (minimum 75%, Missing); lymph node: 6.3529% (minimum 70%, Missing); rectum: 55.1020% (minimum 70%, Missing); small intestine: 25.4717% (minimum 75%, Missing); spleen: 14.6739% (minimum 65%, Missing); thymus: 30.0000% (minimum 65%, Missing)",-0.503261,-0.636471,-0.517241,0,11,partial,8.9,39.8,15.7,"lymph node: 39.8 nTPM (protected, limit 3); spleen: 15.7 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000035720,STAP1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 31.7647% (minimum 75%, Missing); colon: 54.0000% (minimum 70%, Missing); duodenum: 61.3636% (minimum 75%, Missing); kidney: 23.2759% (minimum 75%, Missing); lymph node: 6.3529% (minimum 70%, Missing); rectum: 55.1020% (minimum 70%, Missing); small intestine: 25.4717% (minimum 75%, Missing); spleen: 14.6739% (minimum 65%, Missing); thymus: 30.0000% (minimum 65%, Missing)",-0.503261,-0.636471,-0.517241,0,11,partial,8.9,39.8,15.7,"lymph node: 39.8 nTPM (protected, limit 3); spleen: 15.7 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000035720,STAP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 31.7647% (minimum 75%, Baseline (adaptation disabled)); colon: 54.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.3636% (minimum 75%, Baseline (adaptation disabled)); kidney: 23.2759% (minimum 75%, Baseline (adaptation disabled)); lung: 65.8537% (minimum 75%, Baseline (adaptation disabled)); lymph node: 6.3529% (minimum 70%, Baseline (adaptation disabled)); rectum: 55.1020% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 67.5000% (minimum 70%, Baseline (adaptation disabled)); small intestine: 25.4717% (minimum 75%, Baseline (adaptation disabled)); spleen: 14.6739% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.1020% (minimum 70%, Baseline (adaptation disabled)); thymus: 30.0000% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 61.3636% (minimum 70%, Baseline (adaptation disabled))",-0.503261,-0.636471,-0.517241,0,11,partial,8.9,39.8,15.7,"lymph node: 39.8 nTPM (protected, limit 3); spleen: 15.7 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000035720,STAP1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.8919% (minimum 99%, Missing); basal ganglia: 87.1795% (minimum 99%, Missing); choroid plexus: 54.8387% (minimum 99%, Missing); hippocampal formation: 87.1795% (minimum 99%, Missing); hypothalamus: 85.0000% (minimum 99%, Missing); kidney: 82.9268% (minimum 95%, Enhanced); liver: 79.0698% (minimum 95%, Enhanced); lung: 68.0000% (minimum 99%, Missing); midbrain: 91.8919% (minimum 99%, Missing); pancreas: 79.0698% (minimum 95%, Enhanced); pituitary gland: 62.9630% (minimum 99%, Missing); spinal cord: 97.1429% (minimum 99%, Missing)",0.05,0.0292683,-0.441613,0,5,partial,2.8,0.7,0.9,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000039139,DNAH5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 54.8387% (minimum 75%, Missing); lung: 68.0000% (minimum 75%, Missing); pituitary gland: 62.9630% (minimum 75%, Missing)",0.290698,0.279268,-0.201613,0,5,partial,2.8,0.7,0.9,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000039139,DNAH5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 54.8387% (minimum 75%, Missing); lung: 68.0000% (minimum 75%, Missing); pituitary gland: 62.9630% (minimum 75%, Missing)",0.290698,0.279268,-0.201613,0,5,partial,2.8,0.7,0.9,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000039139,DNAH5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 54.8387% (minimum 75%, Missing); lung: 68.0000% (minimum 75%, Missing); pituitary gland: 62.9630% (minimum 75%, Missing)",0.290698,0.279268,-0.201613,0,5,partial,2.8,0.7,0.9,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000039139,DNAH5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 54.8387% (minimum 75%, Baseline (adaptation disabled)); lung: 68.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 62.9630% (minimum 75%, Baseline (adaptation disabled))",0.140698,0.129268,-0.201613,0,5,partial,2.8,0.7,0.9,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000039139,DNAH5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0411504,0.03,0.00872611,0,1,partial,0.7,0.3,0.7,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000039600,SOX30,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34115,0.3,0.248726,0,1,partial,0.7,0.3,0.7,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000039600,SOX30,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34115,0.3,0.248726,0,1,partial,0.7,0.3,0.7,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000039600,SOX30,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34115,0.3,0.248726,0,1,partial,0.7,0.3,0.7,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000039600,SOX30,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34115,0.296188,0.24115,0,1,partial,0.7,0.3,0.7,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000039600,SOX30,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 88.7892% (minimum 99%, Missing); amygdala: 84.2553% (minimum 99%, Missing); basal ganglia: 92.5234% (minimum 99%, Missing); bone marrow: 95.1923% (minimum 99%, Missing); cerebral cortex: 57.5581% (minimum 99%, Missing); colon: 80.8163% (minimum 97%, Missing); duodenum: 80.1619% (minimum 99%, Missing); esophagus: 59.4595% (minimum 97%, Missing); hippocampal formation: 88.0000% (minimum 99%, Missing); hypothalamus: 82.5000% (minimum 99%, Missing); kidney: 98.5075% (minimum 99%, Missing); liver: 94.2857% (minimum 99%, Missing); lung: 74.1573% (minimum 99%, Missing); midbrain: 90.4110% (minimum 99%, Missing); pancreas: 83.5443% (minimum 99%, Missing); parathyroid gland: 90.0000% (minimum 97%, Missing); pituitary gland: 95.1923% (minimum 99%, Missing); rectum: 79.5181% (minimum 97%, Missing); retina: 95.1923% (minimum 99%, Missing); salivary gland: 59.2814% (minimum 97%, Missing); skin: 56.5714% (minimum 95%, Missing); small intestine: 80.8163% (minimum 99%, Missing); smooth muscle: 95.6522% (minimum 99%, Missing); spinal cord: 97.5369% (minimum 99%, Missing); spleen: 92.5234% (minimum 95%, Missing); stomach: 31.5287% (minimum 97%, Missing); thymus: 93.3962% (minimum 95%, Missing); urinary bladder: 76.7442% (minimum 97%, Missing)",-0.384286,-0.654713,-0.414419,0,3,partial,14.6,43,15.2,"stomach: 43 nTPM (protected, limit 2); skin: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); salivary gland: 13.6 nTPM (protected, limit 2); esophagus: 13.5 nTPM (protected, limit 2); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000041353,RAB27B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 57.5581% (minimum 75%, Missing); esophagus: 59.4595% (minimum 70%, Missing); lung: 74.1573% (minimum 75%, Missing); salivary gland: 59.2814% (minimum 70%, Missing); skin: 56.5714% (minimum 65%, Missing); stomach: 31.5287% (minimum 70%, Missing)",-0.0842857,-0.384713,-0.174419,0,3,partial,14.6,43,15.2,"stomach: 43 nTPM (protected, limit 2); skin: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); salivary gland: 13.6 nTPM (protected, limit 2); esophagus: 13.5 nTPM (protected, limit 2); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000041353,RAB27B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 57.5581% (minimum 75%, Missing); esophagus: 59.4595% (minimum 70%, Missing); lung: 74.1573% (minimum 75%, Missing); salivary gland: 59.2814% (minimum 70%, Missing); skin: 56.5714% (minimum 65%, Missing); stomach: 31.5287% (minimum 70%, Missing)",-0.0842857,-0.384713,-0.174419,0,3,partial,14.6,43,15.2,"stomach: 43 nTPM (protected, limit 3); skin: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); salivary gland: 13.6 nTPM (protected, limit 3); esophagus: 13.5 nTPM (protected, limit 3); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000041353,RAB27B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 57.5581% (minimum 75%, Missing); esophagus: 59.4595% (minimum 70%, Missing); lung: 74.1573% (minimum 75%, Missing); salivary gland: 59.2814% (minimum 70%, Missing); skin: 56.5714% (minimum 65%, Missing); stomach: 31.5287% (minimum 70%, Missing)",-0.0842857,-0.384713,-0.174419,0,3,partial,14.6,43,15.2,"stomach: 43 nTPM (protected, limit 3); skin: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); salivary gland: 13.6 nTPM (protected, limit 3); esophagus: 13.5 nTPM (protected, limit 3); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000041353,RAB27B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 57.5581% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.4595% (minimum 70%, Baseline (adaptation disabled)); lung: 74.1573% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.2814% (minimum 70%, Baseline (adaptation disabled)); skin: 56.5714% (minimum 65%, Baseline (adaptation disabled)); stomach: 31.5287% (minimum 70%, Baseline (adaptation disabled))",-0.0842857,-0.384713,-0.174419,0,3,partial,14.6,43,15.2,"stomach: 43 nTPM (protected, limit 3); skin: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); salivary gland: 13.6 nTPM (protected, limit 3); esophagus: 13.5 nTPM (protected, limit 3); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000041353,RAB27B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 41.6667% (minimum 95%, Missing); adrenal gland: 62.5000% (minimum 99%, Missing); amygdala: 58.8235% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); cerebellum: 71.4286% (minimum 99%, Missing); cerebral cortex: 28.5714% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); duodenum: 90.9091% (minimum 99%, Missing); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 55.5556% (minimum 99%, Missing); hippocampal formation: 52.6316% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); liver: 35.7143% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 83.3333% (minimum 97%, Missing); midbrain: 76.9231% (minimum 99%, Missing); pancreas: 90.9091% (minimum 99%, Missing); pituitary gland: 37.0370% (minimum 99%, Missing); rectum: 90.9091% (minimum 97%, Missing); retina: 71.4286% (minimum 99%, Missing); salivary gland: 90.9091% (minimum 97%, Missing); skin: 90.9091% (minimum 95%, Missing); smooth muscle: 71.4286% (minimum 99%, Missing); spinal cord: 90.9091% (minimum 99%, Missing); tongue: 83.3333% (minimum 97%, Missing)",-0.533333,-0.136667,-0.704286,0,80,unavailable,2.5,0.2,1.4,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000041515,MYO16,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 41.6667% (minimum 65%, Missing); adrenal gland: 62.5000% (minimum 75%, Missing); amygdala: 58.8235% (minimum 75%, Missing); cerebellum: 71.4286% (minimum 75%, Missing); cerebral cortex: 28.5714% (minimum 75%, Missing); heart muscle: 55.5556% (minimum 75%, Missing); hippocampal formation: 52.6316% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); liver: 35.7143% (minimum 75%, Missing); pituitary gland: 37.0370% (minimum 75%, Missing); retina: 71.4286% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing)",-0.233333,0.133333,-0.464286,0,80,unavailable,2.5,0.2,1.4,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000041515,MYO16,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 41.6667% (minimum 65%, Missing); adrenal gland: 62.5000% (minimum 75%, Missing); amygdala: 58.8235% (minimum 75%, Missing); cerebellum: 71.4286% (minimum 75%, Missing); cerebral cortex: 28.5714% (minimum 75%, Missing); heart muscle: 55.5556% (minimum 75%, Missing); hippocampal formation: 52.6316% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); liver: 35.7143% (minimum 75%, Missing); pituitary gland: 37.0370% (minimum 75%, Missing); retina: 71.4286% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing)",-0.233333,0.133333,-0.464286,0,80,unavailable,2.5,0.2,1.4,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000041515,MYO16,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 41.6667% (minimum 65%, Missing); adrenal gland: 62.5000% (minimum 75%, Missing); amygdala: 58.8235% (minimum 75%, Missing); cerebellum: 71.4286% (minimum 75%, Missing); cerebral cortex: 28.5714% (minimum 75%, Missing); heart muscle: 55.5556% (minimum 75%, Missing); hippocampal formation: 52.6316% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); liver: 35.7143% (minimum 75%, Missing); pituitary gland: 37.0370% (minimum 75%, Missing); retina: 71.4286% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing)",-0.233333,0.133333,-0.464286,0,80,unavailable,2.5,0.2,1.4,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000041515,MYO16,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 41.6667% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.5000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 58.8235% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 71.4286% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 28.5714% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 55.5556% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 52.6316% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 35.7143% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 37.0370% (minimum 75%, Baseline (adaptation disabled)); retina: 71.4286% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled))",-0.233333,0.133333,-0.464286,0,80,unavailable,2.5,0.2,1.4,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000041515,MYO16,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4286% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 99%, Missing); heart muscle: 71.4286% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 6.9444% (minimum 99%, Missing); retina: 2.6178% (minimum 99%, Missing); thymus: 83.3333% (minimum 95%, Missing)",-0.116667,0.03,-0.963822,0,80,unavailable,18.6,0,0.1,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000042781,USH2A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4286% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); liver: 6.9444% (minimum 75%, Missing); retina: 2.6178% (minimum 75%, Missing)",0.183333,0.3,-0.723822,0,80,unavailable,18.6,0,0.1,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000042781,USH2A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4286% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); liver: 6.9444% (minimum 75%, Missing); retina: 2.6178% (minimum 75%, Missing)",0.183333,0.3,-0.723822,0,80,unavailable,18.6,0,0.1,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000042781,USH2A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4286% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); liver: 6.9444% (minimum 75%, Missing); retina: 2.6178% (minimum 75%, Missing)",0.183333,0.3,-0.723822,0,80,unavailable,18.6,0,0.1,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000042781,USH2A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4286% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); liver: 6.9444% (minimum 75%, Baseline (adaptation disabled)); retina: 2.6178% (minimum 75%, Baseline (adaptation disabled))",0.183333,0.3,-0.723822,0,80,unavailable,18.6,0,0.1,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000042781,USH2A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 96.8619% (minimum 99%, Missing)",0.05,0.03,-0.0213808,0,1,partial,4.5,0,0.3,"retina: 4.5 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000042813,ZPBP,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.218619,0,1,partial,4.5,0,0.3,"retina: 4.5 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000042813,ZPBP,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.218619,0,1,partial,4.5,0,0.3,"retina: 4.5 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000042813,ZPBP,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.218619,0,1,partial,4.5,0,0.3,"retina: 4.5 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000042813,ZPBP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347845,0.3,0.218619,0,1,partial,4.5,0,0.3,"retina: 4.5 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000042813,ZPBP,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.7143% (minimum 99%, Missing); amygdala: 16.9014% (minimum 99%, Missing); basal ganglia: 23.0769% (minimum 99%, Missing); cerebellum: 0.7678% (minimum 99%, Missing); cerebral cortex: 10.8108% (minimum 99%, Missing); choroid plexus: 5.7971% (minimum 99%, Missing); esophagus: 92.3077% (minimum 97%, Missing); hippocampal formation: 13.1868% (minimum 99%, Missing); hypothalamus: 17.6471% (minimum 99%, Missing); kidney: 92.3077% (minimum 99%, Missing); midbrain: 24.4898% (minimum 99%, Missing); pituitary gland: 52.1739% (minimum 99%, Missing); retina: 33.3333% (minimum 99%, Missing); skin: 92.3077% (minimum 95%, Missing); spinal cord: 17.3913% (minimum 99%, Missing)",-0.0269231,-0.0469231,-0.982322,0,80,unavailable,155.1,0.1,0.1,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000043355,ZIC2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.9014% (minimum 75%, Missing); basal ganglia: 23.0769% (minimum 75%, Missing); cerebellum: 0.7678% (minimum 75%, Missing); cerebral cortex: 10.8108% (minimum 75%, Missing); choroid plexus: 5.7971% (minimum 75%, Missing); hippocampal formation: 13.1868% (minimum 75%, Missing); hypothalamus: 17.6471% (minimum 75%, Missing); midbrain: 24.4898% (minimum 75%, Missing); pituitary gland: 52.1739% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); spinal cord: 17.3913% (minimum 75%, Missing)",0.273077,0.223077,-0.742322,0,80,unavailable,155.1,0.1,0.1,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000043355,ZIC2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.9014% (minimum 75%, Missing); basal ganglia: 23.0769% (minimum 75%, Missing); cerebellum: 0.7678% (minimum 75%, Missing); cerebral cortex: 10.8108% (minimum 75%, Missing); choroid plexus: 5.7971% (minimum 75%, Missing); hippocampal formation: 13.1868% (minimum 75%, Missing); hypothalamus: 17.6471% (minimum 75%, Missing); midbrain: 24.4898% (minimum 75%, Missing); pituitary gland: 52.1739% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); spinal cord: 17.3913% (minimum 75%, Missing)",0.273077,0.223077,-0.742322,0,80,unavailable,155.1,0.1,0.1,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000043355,ZIC2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.9014% (minimum 75%, Missing); basal ganglia: 23.0769% (minimum 75%, Missing); cerebellum: 0.7678% (minimum 75%, Missing); cerebral cortex: 10.8108% (minimum 75%, Missing); choroid plexus: 5.7971% (minimum 75%, Missing); hippocampal formation: 13.1868% (minimum 75%, Missing); hypothalamus: 17.6471% (minimum 75%, Missing); midbrain: 24.4898% (minimum 75%, Missing); pituitary gland: 52.1739% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); spinal cord: 17.3913% (minimum 75%, Missing)",0.273077,0.223077,-0.742322,0,80,unavailable,155.1,0.1,0.1,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000043355,ZIC2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.9014% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 23.0769% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 0.7678% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 10.8108% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 5.7971% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 13.1868% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 17.6471% (minimum 75%, Baseline (adaptation disabled)); midbrain: 24.4898% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 52.1739% (minimum 75%, Baseline (adaptation disabled)); retina: 33.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 17.3913% (minimum 75%, Baseline (adaptation disabled))",0.273077,0.223077,-0.742322,0,80,unavailable,155.1,0.1,0.1,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000043355,ZIC2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2479% (minimum 95%, Uncertain); adrenal gland: 76.2887% (minimum 99%, Missing); amygdala: 85.0575% (minimum 99%, Missing); basal ganglia: 82.2222% (minimum 99%, Missing); bone marrow: 50.6849% (minimum 99%, Missing); cerebellum: 67.8899% (minimum 99%, Missing); cerebral cortex: 81.3187% (minimum 99%, Missing); choroid plexus: 80.4348% (minimum 99%, Missing); colon: 63.2479% (minimum 97%, Missing); duodenum: 86.0465% (minimum 99%, Missing); esophagus: 74.0000% (minimum 97%, Missing); heart muscle: 77.0833% (minimum 99%, Missing); hippocampal formation: 85.0575% (minimum 99%, Missing); hypothalamus: 82.2222% (minimum 99%, Missing); kidney: 76.2887% (minimum 99%, Missing); liver: 42.0455% (minimum 99%, Missing); lung: 73.2673% (minimum 99%, Missing); lymph node: 74.0000% (minimum 97%, Missing); midbrain: 81.3187% (minimum 99%, Missing); pancreas: 81.3187% (minimum 99%, Missing); parathyroid gland: 63.7931% (minimum 97%, Missing); pituitary gland: 77.8947% (minimum 99%, Missing); rectum: 77.8947% (minimum 97%, Missing); retina: 77.8947% (minimum 99%, Missing); salivary gland: 82.2222% (minimum 97%, Missing); skeletal muscle: 83.1461% (minimum 99%, Missing); skin: 79.5699% (minimum 95%, Missing); small intestine: 77.8947% (minimum 99%, Missing); smooth muscle: 63.2479% (minimum 99%, Missing); spinal cord: 79.5699% (minimum 99%, Missing); spleen: 66.0714% (minimum 95%, Missing); stomach: 79.5699% (minimum 97%, Missing); thymus: 73.2673% (minimum 95%, Missing); thyroid gland: 71.1538% (minimum 95%, Missing); tongue: 76.2887% (minimum 97%, Missing); urinary bladder: 69.1589% (minimum 97%, Missing)",-0.317521,-0.337521,-0.569545,0,3,partial,10.2,4.3,4.3,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); adrenal gland: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000044459,CNTLN,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2479% (minimum 65%, Uncertain); bone marrow: 50.6849% (minimum 75%, Missing); cerebellum: 67.8899% (minimum 75%, Missing); colon: 63.2479% (minimum 70%, Missing); liver: 42.0455% (minimum 75%, Missing); lung: 73.2673% (minimum 75%, Missing); parathyroid gland: 63.7931% (minimum 70%, Missing); smooth muscle: 63.2479% (minimum 75%, Missing); urinary bladder: 69.1589% (minimum 70%, Missing)",-0.0175214,-0.0675214,-0.329545,0,3,partial,10.2,4.3,4.3,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); adrenal gland: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000044459,CNTLN,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2479% (minimum 65%, Uncertain); bone marrow: 50.6849% (minimum 75%, Missing); cerebellum: 67.8899% (minimum 75%, Missing); colon: 63.2479% (minimum 70%, Missing); liver: 42.0455% (minimum 75%, Missing); lung: 73.2673% (minimum 75%, Missing); parathyroid gland: 63.7931% (minimum 70%, Missing); smooth muscle: 63.2479% (minimum 75%, Missing); urinary bladder: 69.1589% (minimum 70%, Missing)",-0.0175214,-0.0675214,-0.329545,0,3,partial,10.2,4.3,4.3,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); lung: 2.7 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000044459,CNTLN,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2479% (minimum 65%, Uncertain); bone marrow: 50.6849% (minimum 75%, Missing); cerebellum: 67.8899% (minimum 75%, Missing); colon: 63.2479% (minimum 70%, Missing); liver: 42.0455% (minimum 75%, Missing); lung: 73.2673% (minimum 75%, Missing); parathyroid gland: 63.7931% (minimum 70%, Missing); smooth muscle: 63.2479% (minimum 75%, Missing); urinary bladder: 69.1589% (minimum 70%, Missing)",-0.0175214,-0.0675214,-0.329545,0,3,partial,10.2,4.3,4.3,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); lung: 2.7 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000044459,CNTLN,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2479% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 50.6849% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.8899% (minimum 75%, Baseline (adaptation disabled)); colon: 63.2479% (minimum 70%, Baseline (adaptation disabled)); liver: 42.0455% (minimum 75%, Baseline (adaptation disabled)); lung: 73.2673% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.7931% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 63.2479% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 69.1589% (minimum 70%, Baseline (adaptation disabled))",-0.0175214,-0.0675214,-0.329545,0,3,partial,10.2,4.3,4.3,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); lung: 2.7 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000044459,CNTLN,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000046774,MAGEC2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000046774,MAGEC2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000046774,MAGEC2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000046774,MAGEC2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000046774,MAGEC2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.6842% (minimum 99%, Missing); basal ganglia: 90.8163% (minimum 99%, Missing); cerebral cortex: 91.7526% (minimum 95%, Enhanced); choroid plexus: 74.1667% (minimum 99%, Missing); heart muscle: 70.6349% (minimum 95%, Enhanced); hippocampal formation: 93.6842% (minimum 99%, Missing); hypothalamus: 94.6809% (minimum 99%, Missing); lung: 70.6349% (minimum 95%, Enhanced); midbrain: 93.6842% (minimum 99%, Missing); pituitary gland: 97.8022% (minimum 99%, Missing); retina: 4.2686% (minimum 99%, Missing); skeletal muscle: 86.4078% (minimum 95%, Enhanced); small intestine: 92.7083% (minimum 95%, Enhanced); smooth muscle: 89.0000% (minimum 95%, Enhanced); spinal cord: 92.7083% (minimum 99%, Missing); tongue: 74.1667% (minimum 97%, Missing)",0.0223776,-0.228333,-0.947314,0,3,partial,199.6,3.1,5.4,"retina: 199.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000047617,ANO2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 74.1667% (minimum 75%, Missing); retina: 4.2686% (minimum 75%, Missing)",0.122378,0.0416667,-0.707314,0,3,partial,199.6,3.1,5.4,"retina: 199.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000047617,ANO2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 74.1667% (minimum 75%, Missing); retina: 4.2686% (minimum 75%, Missing)",0.122378,0.0416667,-0.707314,0,3,partial,199.6,3.1,5.4,"retina: 199.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000047617,ANO2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 74.1667% (minimum 75%, Missing); retina: 4.2686% (minimum 75%, Missing)",0.122378,0.0416667,-0.707314,0,3,partial,199.6,3.1,5.4,"retina: 199.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000047617,ANO2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2378% (minimum 65%, Baseline (adaptation disabled)); choroid plexus: 74.1667% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.6349% (minimum 75%, Baseline (adaptation disabled)); lung: 70.6349% (minimum 75%, Baseline (adaptation disabled)); retina: 4.2686% (minimum 75%, Baseline (adaptation disabled))",-0.0276224,0.0416667,-0.707314,0,3,partial,199.6,3.1,5.4,"retina: 199.6 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); skeletal muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000047617,ANO2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.4775% (minimum 90%, Approved); adrenal gland: 62.2951% (minimum 99%, Missing); amygdala: 66.4723% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 76.5101% (minimum 99%, Missing); cerebellum: 53.1469% (minimum 99%, Missing); cerebral cortex: 56.1576% (minimum 99%, Missing); choroid plexus: 81.7204% (minimum 99%, Missing); colon: 55.7457% (minimum 97%, Missing); duodenum: 65.7061% (minimum 99%, Missing); esophagus: 66.0870% (minimum 97%, Missing); heart muscle: 51.7007% (minimum 99%, Missing); hippocampal formation: 63.6872% (minimum 99%, Missing); hypothalamus: 64.9573% (minimum 99%, Missing); kidney: 61.9565% (minimum 99%, Missing); liver: 58.9147% (minimum 99%, Missing); lung: 63.5097% (minimum 99%, Missing); lymph node: 53.9007% (minimum 97%, Missing); midbrain: 65.8960% (minimum 99%, Missing); pancreas: 64.9573% (minimum 99%, Missing); parathyroid gland: 51.5837% (minimum 95%, Approved); pituitary gland: 59.2208% (minimum 99%, Missing); rectum: 53.6471% (minimum 97%, Missing); retina: 63.5097% (minimum 99%, Missing); salivary gland: 62.1253% (minimum 97%, Missing); skeletal muscle: 60.0000% (minimum 99%, Missing); skin: 55.6098% (minimum 95%, Missing); small intestine: 60.9626% (minimum 99%, Missing); smooth muscle: 56.2963% (minimum 98%, Approved); spinal cord: 63.1579% (minimum 99%, Missing); spleen: 58.0153% (minimum 90%, Approved); stomach: 61.1260% (minimum 97%, Missing); thymus: 52.7778% (minimum 95%, Missing); thyroid gland: 49.5652% (minimum 95%, Missing); tongue: 57.7215% (minimum 97%, Missing); urinary bladder: 60.9626% (minimum 97%, Missing)",-0.454348,-0.434163,-0.472993,0,4,partial,21.3,21.4,23.2,"thyroid gland: 23.2 nTPM (manageable, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 4); heart muscle: 21.3 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 2); lymph node: 19.5 nTPM (protected, limit 2); skin: 18.2 nTPM (manageable, limit 5); colon: 18.1 nTPM (protected, limit 2); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 2); tongue: 16.7 nTPM (protected, limit 2); spleen: 16.5 nTPM (manageable, limit 10); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 10); small intestine: 14.6 nTPM (vital, limit 1); urinary bladder: 14.6 nTPM (protected, limit 2); stomach: 14.5 nTPM (protected, limit 2); kidney: 14 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 2); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000047932,GOPC,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.2951% (minimum 75%, Missing); amygdala: 66.4723% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 53.1469% (minimum 75%, Missing); cerebral cortex: 56.1576% (minimum 75%, Missing); colon: 55.7457% (minimum 70%, Missing); duodenum: 65.7061% (minimum 75%, Missing); esophagus: 66.0870% (minimum 70%, Missing); heart muscle: 51.7007% (minimum 75%, Missing); hippocampal formation: 63.6872% (minimum 75%, Missing); hypothalamus: 64.9573% (minimum 75%, Missing); kidney: 61.9565% (minimum 75%, Missing); liver: 58.9147% (minimum 75%, Missing); lung: 63.5097% (minimum 75%, Missing); lymph node: 53.9007% (minimum 70%, Missing); midbrain: 65.8960% (minimum 75%, Missing); pancreas: 64.9573% (minimum 75%, Missing); parathyroid gland: 51.5837% (minimum 65%, Approved); pituitary gland: 59.2208% (minimum 75%, Missing); rectum: 53.6471% (minimum 70%, Missing); retina: 63.5097% (minimum 75%, Missing); salivary gland: 62.1253% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); skin: 55.6098% (minimum 65%, Missing); small intestine: 60.9626% (minimum 75%, Missing); smooth muscle: 56.2963% (minimum 70%, Approved); spinal cord: 63.1579% (minimum 75%, Missing); spleen: 58.0153% (minimum 60%, Approved); stomach: 61.1260% (minimum 70%, Missing); thymus: 52.7778% (minimum 65%, Missing); thyroid gland: 49.5652% (minimum 65%, Missing); tongue: 57.7215% (minimum 70%, Missing); urinary bladder: 60.9626% (minimum 70%, Missing)",-0.154348,-0.163529,-0.232993,0,4,partial,21.3,21.4,23.2,"thyroid gland: 23.2 nTPM (manageable, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 4); heart muscle: 21.3 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 2); lymph node: 19.5 nTPM (protected, limit 2); skin: 18.2 nTPM (manageable, limit 5); colon: 18.1 nTPM (protected, limit 2); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 2); tongue: 16.7 nTPM (protected, limit 2); spleen: 16.5 nTPM (manageable, limit 10); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 10); small intestine: 14.6 nTPM (vital, limit 1); urinary bladder: 14.6 nTPM (protected, limit 2); stomach: 14.5 nTPM (protected, limit 2); kidney: 14 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 2); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000047932,GOPC,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.2951% (minimum 75%, Missing); amygdala: 66.4723% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 53.1469% (minimum 75%, Missing); cerebral cortex: 56.1576% (minimum 75%, Missing); colon: 55.7457% (minimum 70%, Missing); duodenum: 65.7061% (minimum 75%, Missing); esophagus: 66.0870% (minimum 70%, Missing); heart muscle: 51.7007% (minimum 75%, Missing); hippocampal formation: 63.6872% (minimum 75%, Missing); hypothalamus: 64.9573% (minimum 75%, Missing); kidney: 61.9565% (minimum 75%, Missing); liver: 58.9147% (minimum 75%, Missing); lung: 63.5097% (minimum 75%, Missing); lymph node: 53.9007% (minimum 70%, Missing); midbrain: 65.8960% (minimum 75%, Missing); pancreas: 64.9573% (minimum 75%, Missing); parathyroid gland: 51.5837% (minimum 65%, Approved); pituitary gland: 59.2208% (minimum 75%, Missing); rectum: 53.6471% (minimum 70%, Missing); retina: 63.5097% (minimum 75%, Missing); salivary gland: 62.1253% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); skin: 55.6098% (minimum 65%, Missing); small intestine: 60.9626% (minimum 75%, Missing); smooth muscle: 56.2963% (minimum 70%, Approved); spinal cord: 63.1579% (minimum 75%, Missing); spleen: 58.0153% (minimum 60%, Approved); stomach: 61.1260% (minimum 70%, Missing); thymus: 52.7778% (minimum 65%, Missing); thyroid gland: 49.5652% (minimum 65%, Missing); tongue: 57.7215% (minimum 70%, Missing); urinary bladder: 60.9626% (minimum 70%, Missing)",-0.154348,-0.163529,-0.232993,0,4,partial,21.3,21.4,23.2,"thyroid gland: 23.2 nTPM (manageable, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 4); heart muscle: 21.3 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 3); lymph node: 19.5 nTPM (protected, limit 3); skin: 18.2 nTPM (manageable, limit 5); colon: 18.1 nTPM (protected, limit 3); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 2); tongue: 16.7 nTPM (protected, limit 3); spleen: 16.5 nTPM (manageable, limit 10); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 10); small intestine: 14.6 nTPM (vital, limit 1); urinary bladder: 14.6 nTPM (protected, limit 3); stomach: 14.5 nTPM (protected, limit 3); kidney: 14 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 3); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000047932,GOPC,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.2951% (minimum 75%, Missing); amygdala: 66.4723% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 53.1469% (minimum 75%, Missing); cerebral cortex: 56.1576% (minimum 75%, Missing); colon: 55.7457% (minimum 70%, Missing); duodenum: 65.7061% (minimum 75%, Missing); esophagus: 66.0870% (minimum 70%, Missing); heart muscle: 51.7007% (minimum 75%, Missing); hippocampal formation: 63.6872% (minimum 75%, Missing); hypothalamus: 64.9573% (minimum 75%, Missing); kidney: 61.9565% (minimum 75%, Missing); liver: 58.9147% (minimum 75%, Missing); lung: 63.5097% (minimum 75%, Missing); lymph node: 53.9007% (minimum 70%, Missing); midbrain: 65.8960% (minimum 75%, Missing); pancreas: 64.9573% (minimum 75%, Missing); parathyroid gland: 51.5837% (minimum 65%, Approved); pituitary gland: 59.2208% (minimum 75%, Missing); rectum: 53.6471% (minimum 70%, Missing); retina: 63.5097% (minimum 75%, Missing); salivary gland: 62.1253% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); skin: 55.6098% (minimum 65%, Missing); small intestine: 60.9626% (minimum 75%, Missing); smooth muscle: 56.2963% (minimum 70%, Approved); spinal cord: 63.1579% (minimum 75%, Missing); spleen: 58.0153% (minimum 60%, Approved); stomach: 61.1260% (minimum 70%, Missing); thymus: 52.7778% (minimum 65%, Missing); thyroid gland: 49.5652% (minimum 65%, Missing); tongue: 57.7215% (minimum 70%, Missing); urinary bladder: 60.9626% (minimum 70%, Missing)",-0.154348,-0.163529,-0.232993,0,4,partial,21.3,21.4,23.2,"thyroid gland: 23.2 nTPM (manageable, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 4); heart muscle: 21.3 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 3); lymph node: 19.5 nTPM (protected, limit 3); skin: 18.2 nTPM (manageable, limit 5); colon: 18.1 nTPM (protected, limit 3); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 2); tongue: 16.7 nTPM (protected, limit 3); spleen: 16.5 nTPM (manageable, limit 10); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 10); small intestine: 14.6 nTPM (vital, limit 1); urinary bladder: 14.6 nTPM (protected, limit 3); stomach: 14.5 nTPM (protected, limit 3); kidney: 14 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 3); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000047932,GOPC,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.4775% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.2951% (minimum 75%, Baseline (adaptation disabled)); amygdala: 66.4723% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 53.1469% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.1576% (minimum 75%, Baseline (adaptation disabled)); colon: 55.7457% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.7061% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.0870% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 51.7007% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.6872% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.9573% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.9565% (minimum 75%, Baseline (adaptation disabled)); liver: 58.9147% (minimum 75%, Baseline (adaptation disabled)); lung: 63.5097% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.9007% (minimum 70%, Baseline (adaptation disabled)); midbrain: 65.8960% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.9573% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.5837% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 59.2208% (minimum 75%, Baseline (adaptation disabled)); rectum: 53.6471% (minimum 70%, Baseline (adaptation disabled)); retina: 63.5097% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.1253% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 55.6098% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.9626% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.2963% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.1579% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.0153% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.1260% (minimum 70%, Baseline (adaptation disabled)); thymus: 52.7778% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 49.5652% (minimum 65%, Baseline (adaptation disabled)); tongue: 57.7215% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.9626% (minimum 70%, Baseline (adaptation disabled))",-0.154348,-0.184163,-0.232993,0,4,partial,21.3,21.4,23.2,"thyroid gland: 23.2 nTPM (manageable, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 3); heart muscle: 21.3 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 3); lymph node: 19.5 nTPM (protected, limit 3); skin: 18.2 nTPM (manageable, limit 5); colon: 18.1 nTPM (protected, limit 3); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 1); tongue: 16.7 nTPM (protected, limit 3); spleen: 16.5 nTPM (manageable, limit 5); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); small intestine: 14.6 nTPM (vital, limit 1); urinary bladder: 14.6 nTPM (protected, limit 3); stomach: 14.5 nTPM (protected, limit 3); kidney: 14 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 3); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000047932,GOPC,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.6744% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); cerebral cortex: 90.3226% (minimum 97%, Supported); choroid plexus: 77.7778% (minimum 99%, Missing); hippocampal formation: 98.8235% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); midbrain: 98.8235% (minimum 99%, Missing); retina: 1.1312% (minimum 99%, Missing)",0.05,0.03,-0.978688,0,0,routine_complete,734.2,0.1,0.1,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000048545,GUCA1A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 1.1312% (minimum 75%, Missing)",0.35,0.3,-0.738688,0,0,routine_complete,734.2,0.1,0.1,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000048545,GUCA1A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 1.1312% (minimum 75%, Missing)",0.35,0.3,-0.738688,0,0,routine_complete,734.2,0.1,0.1,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000048545,GUCA1A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 1.1312% (minimum 75%, Missing)",0.35,0.3,-0.738688,0,0,routine_complete,734.2,0.1,0.1,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000048545,GUCA1A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 1.1312% (minimum 75%, Baseline (adaptation disabled))",0.338235,0.288235,-0.738688,0,0,routine_complete,734.2,0.1,0.1,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000048545,GUCA1A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.9481% (minimum 95%, Missing); adrenal gland: 57.1429% (minimum 99%, Missing); amygdala: 54.0541% (minimum 99%, Missing); basal ganglia: 54.7945% (minimum 99%, Missing); bone marrow: 60.6061% (minimum 99%, Missing); cerebellum: 72.7273% (minimum 99%, Missing); cerebral cortex: 58.8235% (minimum 99%, Missing); choroid plexus: 70.1754% (minimum 99%, Missing); colon: 55.5556% (minimum 97%, Missing); duodenum: 61.5385% (minimum 99%, Missing); esophagus: 59.7015% (minimum 97%, Missing); heart muscle: 54.0541% (minimum 99%, Missing); hippocampal formation: 57.1429% (minimum 99%, Missing); hypothalamus: 55.5556% (minimum 99%, Missing); kidney: 50.0000% (minimum 99%, Missing); liver: 54.0541% (minimum 99%, Missing); lung: 65.5738% (minimum 99%, Missing); lymph node: 62.5000% (minimum 97%, Missing); midbrain: 51.9481% (minimum 99%, Missing); pancreas: 60.6061% (minimum 99%, Missing); parathyroid gland: 53.3333% (minimum 97%, Missing); pituitary gland: 62.5000% (minimum 99%, Missing); rectum: 54.0541% (minimum 97%, Missing); retina: 52.6316% (minimum 99%, Missing); salivary gland: 60.6061% (minimum 97%, Missing); skeletal muscle: 57.9710% (minimum 99%, Missing); skin: 63.4921% (minimum 95%, Missing); small intestine: 64.5161% (minimum 99%, Missing); smooth muscle: 54.7945% (minimum 99%, Missing); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 57.1429% (minimum 95%, Missing); stomach: 61.5385% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing); thyroid gland: 57.9710% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",-0.45,-0.47,-0.49,0,80,unavailable,4,4,4,"tongue: 4 nTPM (protected, limit 2); spinal cord: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); amygdala: 3.4 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); pancreas: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049167,ERCC8,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.9481% (minimum 65%, Missing); adrenal gland: 57.1429% (minimum 75%, Missing); amygdala: 54.0541% (minimum 75%, Missing); basal ganglia: 54.7945% (minimum 75%, Missing); bone marrow: 60.6061% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); choroid plexus: 70.1754% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 61.5385% (minimum 75%, Missing); esophagus: 59.7015% (minimum 70%, Missing); heart muscle: 54.0541% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 54.0541% (minimum 75%, Missing); lung: 65.5738% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); midbrain: 51.9481% (minimum 75%, Missing); pancreas: 60.6061% (minimum 75%, Missing); parathyroid gland: 53.3333% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 54.0541% (minimum 70%, Missing); retina: 52.6316% (minimum 75%, Missing); salivary gland: 60.6061% (minimum 70%, Missing); skeletal muscle: 57.9710% (minimum 75%, Missing); skin: 63.4921% (minimum 65%, Missing); small intestine: 64.5161% (minimum 75%, Missing); smooth muscle: 54.7945% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 61.5385% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 57.9710% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.15,-0.2,-0.25,0,80,unavailable,4,4,4,"tongue: 4 nTPM (protected, limit 2); spinal cord: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); amygdala: 3.4 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); pancreas: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049167,ERCC8,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.9481% (minimum 65%, Missing); adrenal gland: 57.1429% (minimum 75%, Missing); amygdala: 54.0541% (minimum 75%, Missing); basal ganglia: 54.7945% (minimum 75%, Missing); bone marrow: 60.6061% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); choroid plexus: 70.1754% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 61.5385% (minimum 75%, Missing); esophagus: 59.7015% (minimum 70%, Missing); heart muscle: 54.0541% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 54.0541% (minimum 75%, Missing); lung: 65.5738% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); midbrain: 51.9481% (minimum 75%, Missing); pancreas: 60.6061% (minimum 75%, Missing); parathyroid gland: 53.3333% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 54.0541% (minimum 70%, Missing); retina: 52.6316% (minimum 75%, Missing); salivary gland: 60.6061% (minimum 70%, Missing); skeletal muscle: 57.9710% (minimum 75%, Missing); skin: 63.4921% (minimum 65%, Missing); small intestine: 64.5161% (minimum 75%, Missing); smooth muscle: 54.7945% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 61.5385% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 57.9710% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.15,-0.2,-0.25,0,80,unavailable,4,4,4,"tongue: 4 nTPM (protected, limit 3); spinal cord: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); amygdala: 3.4 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049167,ERCC8,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.9481% (minimum 65%, Missing); adrenal gland: 57.1429% (minimum 75%, Missing); amygdala: 54.0541% (minimum 75%, Missing); basal ganglia: 54.7945% (minimum 75%, Missing); bone marrow: 60.6061% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); choroid plexus: 70.1754% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 61.5385% (minimum 75%, Missing); esophagus: 59.7015% (minimum 70%, Missing); heart muscle: 54.0541% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 54.0541% (minimum 75%, Missing); lung: 65.5738% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); midbrain: 51.9481% (minimum 75%, Missing); pancreas: 60.6061% (minimum 75%, Missing); parathyroid gland: 53.3333% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 54.0541% (minimum 70%, Missing); retina: 52.6316% (minimum 75%, Missing); salivary gland: 60.6061% (minimum 70%, Missing); skeletal muscle: 57.9710% (minimum 75%, Missing); skin: 63.4921% (minimum 65%, Missing); small intestine: 64.5161% (minimum 75%, Missing); smooth muscle: 54.7945% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 61.5385% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 57.9710% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.15,-0.2,-0.25,0,80,unavailable,4,4,4,"tongue: 4 nTPM (protected, limit 3); spinal cord: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); amygdala: 3.4 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049167,ERCC8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.9481% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 57.1429% (minimum 75%, Baseline (adaptation disabled)); amygdala: 54.0541% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.7945% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 60.6061% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.7273% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.8235% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.1754% (minimum 75%, Baseline (adaptation disabled)); colon: 55.5556% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.5385% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.7015% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 54.0541% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.1429% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.5556% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 54.0541% (minimum 75%, Baseline (adaptation disabled)); lung: 65.5738% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.5000% (minimum 70%, Baseline (adaptation disabled)); midbrain: 51.9481% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.6061% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 53.3333% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.5000% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.0541% (minimum 70%, Baseline (adaptation disabled)); retina: 52.6316% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.6061% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 57.9710% (minimum 75%, Baseline (adaptation disabled)); skin: 63.4921% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.5161% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 54.7945% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.1429% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.5385% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.9710% (minimum 65%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 70%, Baseline (adaptation disabled))",-0.15,-0.2,-0.25,0,80,unavailable,4,4,4,"tongue: 4 nTPM (protected, limit 3); spinal cord: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); amygdala: 3.4 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049167,ERCC8,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.7368% (minimum 95%, Enhanced); amygdala: 94.7368% (minimum 99%, Missing); basal ganglia: 94.7368% (minimum 99%, Missing); cerebral cortex: 81.8182% (minimum 95%, Enhanced); choroid plexus: 78.2609% (minimum 99%, Missing); duodenum: 94.7368% (minimum 95%, Enhanced); heart muscle: 85.7143% (minimum 95%, Enhanced); hippocampal formation: 94.7368% (minimum 99%, Missing); hypothalamus: 94.7368% (minimum 99%, Missing); kidney: 90.0000% (minimum 95%, Enhanced); lung: 78.2609% (minimum 95%, Enhanced); midbrain: 94.7368% (minimum 99%, Missing); pituitary gland: 94.7368% (minimum 99%, Missing); retina: 90.0000% (minimum 99%, Missing); small intestine: 75.0000% (minimum 95%, Enhanced); smooth muscle: 75.0000% (minimum 95%, Enhanced); spinal cord: 94.7368% (minimum 99%, Missing); thymus: 90.0000% (minimum 95%, Missing); tongue: 94.7368% (minimum 97%, Missing); urinary bladder: 72.0000% (minimum 80%, Enhanced)",-0.05,-0.08,-0.207391,0,2,partial,0.6,0.7,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049192,ADAMTS6,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.25,0.17,0.0326087,0,2,partial,0.6,0.7,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049192,ADAMTS6,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.25,0.17,0.0326087,0,2,partial,0.6,0.7,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049192,ADAMTS6,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.25,0.17,0.0326087,0,2,partial,0.6,0.7,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049192,ADAMTS6,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.1,0.02,0,0,2,partial,0.6,0.7,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049192,ADAMTS6,current_fixed,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 89.2857% (minimum 99%, Missing); basal ganglia: 89.2857% (minimum 99%, Missing); bone marrow: 83.3333% (minimum 95%, Enhanced); cerebellum: 86.2069% (minimum 95%, Enhanced); cerebral cortex: 89.2857% (minimum 95%, Enhanced); duodenum: 89.2857% (minimum 95%, Enhanced); hippocampal formation: 89.2857% (minimum 99%, Missing); hypothalamus: 92.5926% (minimum 99%, Missing); kidney: 94.3396% (minimum 95%, Enhanced); liver: 68.4932% (minimum 95%, Enhanced); lung: 86.2069% (minimum 99%, Missing); lymph node: 47.1698% (minimum 97%, Missing); midbrain: 92.5926% (minimum 99%, Missing); pituitary gland: 90.9091% (minimum 99%, Missing); retina: 92.5926% (minimum 99%, Missing); skeletal muscle: 94.3396% (minimum 95%, Enhanced); small intestine: 73.5294% (minimum 95%, Enhanced); smooth muscle: 94.3396% (minimum 95%, Enhanced); spinal cord: 94.3396% (minimum 99%, Missing); spleen: 68.4932% (minimum 95%, Missing); stomach: 75.7576% (minimum 80%, Enhanced); thymus: 43.1034% (minimum 95%, Missing); urinary bladder: 65.7895% (minimum 80%, Enhanced)",-0.518966,-0.498302,-0.265068,0,2,partial,2.3,5.6,6.6,"thymus: 6.6 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2)",lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049768,FOXP3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 47.1698% (minimum 70%, Missing); thymus: 43.1034% (minimum 65%, Missing)",-0.218966,-0.228302,0.0849315,0,2,partial,2.3,5.6,6.6,"thymus: 6.6 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2)",lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049768,FOXP3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 47.1698% (minimum 70%, Missing); thymus: 43.1034% (minimum 65%, Missing)",-0.218966,-0.228302,0.0849315,0,2,partial,2.3,5.6,6.6,"thymus: 6.6 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3)",lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049768,FOXP3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 47.1698% (minimum 70%, Missing); thymus: 43.1034% (minimum 65%, Missing)",-0.218966,-0.228302,0.0849315,0,2,partial,2.3,5.6,6.6,"thymus: 6.6 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3)",lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049768,FOXP3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"liver: 68.4932% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.1698% (minimum 70%, Baseline (adaptation disabled)); small intestine: 73.5294% (minimum 75%, Baseline (adaptation disabled)); thymus: 43.1034% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 65.7895% (minimum 70%, Baseline (adaptation disabled))",-0.218966,-0.228302,-0.0650685,0,2,partial,2.3,5.6,6.6,"thymus: 6.6 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3); liver: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000049768,FOXP3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.0000% (minimum 95%, Missing); adrenal gland: 50.0000% (minimum 99%, Missing); amygdala: 45.0000% (minimum 99%, Missing); basal ganglia: 37.5000% (minimum 99%, Missing); cerebellum: 33.3333% (minimum 99%, Missing); cerebral cortex: 23.0769% (minimum 99%, Missing); choroid plexus: 69.2308% (minimum 99%, Missing); colon: 52.9412% (minimum 97%, Missing); duodenum: 90.0000% (minimum 99%, Missing); esophagus: 81.8182% (minimum 97%, Missing); hippocampal formation: 47.3684% (minimum 99%, Missing); hypothalamus: 30.0000% (minimum 99%, Missing); kidney: 56.2500% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); lymph node: 90.0000% (minimum 97%, Missing); midbrain: 64.2857% (minimum 99%, Missing); pancreas: 39.1304% (minimum 99%, Missing); parathyroid gland: 33.3333% (minimum 97%, Missing); pituitary gland: 34.6154% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 69.2308% (minimum 97%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 69.2308% (minimum 99%, Missing); smooth muscle: 56.2500% (minimum 99%, Missing); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 90.0000% (minimum 95%, Missing); stomach: 60.0000% (minimum 97%, Missing); thyroid gland: 69.2308% (minimum 95%, Missing); tongue: 90.0000% (minimum 97%, Missing); urinary bladder: 81.8182% (minimum 97%, Missing)",-0.257692,-0.636667,-0.759231,0,80,unavailable,3,1.8,0.4,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000050030,NEXMIF,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 45.0000% (minimum 75%, Missing); basal ganglia: 37.5000% (minimum 75%, Missing); cerebellum: 33.3333% (minimum 75%, Missing); cerebral cortex: 23.0769% (minimum 75%, Missing); choroid plexus: 69.2308% (minimum 75%, Missing); colon: 52.9412% (minimum 70%, Missing); hippocampal formation: 47.3684% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); kidney: 56.2500% (minimum 75%, Missing); midbrain: 64.2857% (minimum 75%, Missing); pancreas: 39.1304% (minimum 75%, Missing); parathyroid gland: 33.3333% (minimum 70%, Missing); pituitary gland: 34.6154% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 69.2308% (minimum 70%, Missing); small intestine: 69.2308% (minimum 75%, Missing); smooth muscle: 56.2500% (minimum 75%, Missing); stomach: 60.0000% (minimum 70%, Missing)",0.0423077,-0.366667,-0.519231,0,80,unavailable,3,1.8,0.4,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000050030,NEXMIF,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 45.0000% (minimum 75%, Missing); basal ganglia: 37.5000% (minimum 75%, Missing); cerebellum: 33.3333% (minimum 75%, Missing); cerebral cortex: 23.0769% (minimum 75%, Missing); choroid plexus: 69.2308% (minimum 75%, Missing); colon: 52.9412% (minimum 70%, Missing); hippocampal formation: 47.3684% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); kidney: 56.2500% (minimum 75%, Missing); midbrain: 64.2857% (minimum 75%, Missing); pancreas: 39.1304% (minimum 75%, Missing); parathyroid gland: 33.3333% (minimum 70%, Missing); pituitary gland: 34.6154% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 69.2308% (minimum 70%, Missing); small intestine: 69.2308% (minimum 75%, Missing); smooth muscle: 56.2500% (minimum 75%, Missing); stomach: 60.0000% (minimum 70%, Missing)",0.0423077,-0.366667,-0.519231,0,80,unavailable,3,1.8,0.4,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000050030,NEXMIF,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 45.0000% (minimum 75%, Missing); basal ganglia: 37.5000% (minimum 75%, Missing); cerebellum: 33.3333% (minimum 75%, Missing); cerebral cortex: 23.0769% (minimum 75%, Missing); choroid plexus: 69.2308% (minimum 75%, Missing); colon: 52.9412% (minimum 70%, Missing); hippocampal formation: 47.3684% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); kidney: 56.2500% (minimum 75%, Missing); midbrain: 64.2857% (minimum 75%, Missing); pancreas: 39.1304% (minimum 75%, Missing); parathyroid gland: 33.3333% (minimum 70%, Missing); pituitary gland: 34.6154% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 69.2308% (minimum 70%, Missing); small intestine: 69.2308% (minimum 75%, Missing); smooth muscle: 56.2500% (minimum 75%, Missing); stomach: 60.0000% (minimum 70%, Missing)",0.0423077,-0.366667,-0.519231,0,80,unavailable,3,1.8,0.4,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000050030,NEXMIF,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 45.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 37.5000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 33.3333% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 23.0769% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.2308% (minimum 75%, Baseline (adaptation disabled)); colon: 52.9412% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 47.3684% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 30.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.2500% (minimum 75%, Baseline (adaptation disabled)); midbrain: 64.2857% (minimum 75%, Baseline (adaptation disabled)); pancreas: 39.1304% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 33.3333% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 34.6154% (minimum 75%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 69.2308% (minimum 70%, Baseline (adaptation disabled)); small intestine: 69.2308% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.2500% (minimum 75%, Baseline (adaptation disabled)); stomach: 60.0000% (minimum 70%, Baseline (adaptation disabled))",0.0423077,-0.366667,-0.519231,0,80,unavailable,3,1.8,0.4,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000050030,NEXMIF,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.9167% (minimum 99%, Missing); basal ganglia: 98.7395% (minimum 99%, Missing); bone marrow: 69.5266% (minimum 99%, Missing); choroid plexus: 98.3264% (minimum 99%, Missing); colon: 74.6032% (minimum 97%, Missing); duodenum: 88.0150% (minimum 99%, Missing); esophagus: 85.4545% (minimum 97%, Missing); kidney: 97.9167% (minimum 99%, Missing); liver: 94.7581% (minimum 95%, Enhanced); lung: 95.5285% (minimum 99%, Missing); lymph node: 68.7135% (minimum 97%, Missing); pancreas: 94.7581% (minimum 95%, Enhanced); rectum: 72.7554% (minimum 97%, Missing); retina: 98.7395% (minimum 99%, Missing); salivary gland: 95.9184% (minimum 97%, Missing); skin: 88.6792% (minimum 95%, Missing); small intestine: 85.4545% (minimum 99%, Missing); smooth muscle: 91.0853% (minimum 95%, Enhanced); stomach: 92.8854% (minimum 97%, Missing); thymus: 60.7235% (minimum 95%, Missing); urinary bladder: 93.2540% (minimum 97%, Missing)",-0.342765,-0.282865,-0.294734,0,6,partial,10.3,10.7,15.2,"thymus: 15.2 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 2); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); colon: 8 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / sebaceous glands: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thymus / cortical cells: High (Enhanced); thymus / medullary cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / langerhans cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / sebaceous glands; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000051180,RAD51,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5266% (minimum 75%, Missing); lymph node: 68.7135% (minimum 70%, Missing); thymus: 60.7235% (minimum 65%, Missing)",-0.0427649,-0.0128655,-0.0547337,0,6,partial,10.3,10.7,15.2,"thymus: 15.2 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 2); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); colon: 8 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / sebaceous glands: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thymus / cortical cells: High (Enhanced); thymus / medullary cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / langerhans cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / sebaceous glands; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000051180,RAD51,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5266% (minimum 75%, Missing); lymph node: 68.7135% (minimum 70%, Missing); thymus: 60.7235% (minimum 65%, Missing)",-0.0427649,-0.0128655,-0.0547337,0,6,partial,10.3,10.7,15.2,"thymus: 15.2 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 3); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 3); colon: 8 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / sebaceous glands: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thymus / cortical cells: High (Enhanced); thymus / medullary cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / langerhans cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / sebaceous glands; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000051180,RAD51,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5266% (minimum 75%, Missing); lymph node: 68.7135% (minimum 70%, Missing); thymus: 60.7235% (minimum 65%, Missing)",-0.0427649,-0.0128655,-0.0547337,0,6,partial,10.3,10.7,15.2,"thymus: 15.2 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 3); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 3); colon: 8 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / sebaceous glands: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thymus / cortical cells: High (Enhanced); thymus / medullary cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / langerhans cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / sebaceous glands; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000051180,RAD51,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5266% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.7135% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.7235% (minimum 65%, Baseline (adaptation disabled))",-0.0427649,-0.0128655,-0.0547337,0,6,partial,10.3,10.7,15.2,"thymus: 15.2 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 3); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 3); colon: 8 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / sebaceous glands: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thymus / cortical cells: High (Enhanced); thymus / medullary cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / langerhans cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / sebaceous glands; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000051180,RAD51,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.3043% (minimum 99%, Missing); bone marrow: 26.2500% (minimum 99%, Missing); cerebellum: 95.4545% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); colon: 63.6364% (minimum 97%, Missing); duodenum: 65.6250% (minimum 99%, Missing); esophagus: 52.5000% (minimum 97%, Missing); heart muscle: 91.3043% (minimum 99%, Missing); liver: 95.4545% (minimum 99%, Missing); lung: 91.3043% (minimum 99%, Missing); lymph node: 43.7500% (minimum 97%, Missing); parathyroid gland: 95.4545% (minimum 97%, Missing); rectum: 52.5000% (minimum 97%, Missing); salivary gland: 91.3043% (minimum 97%, Missing); skin: 60.0000% (minimum 95%, Missing); small intestine: 70.0000% (minimum 99%, Missing); smooth muscle: 84.0000% (minimum 99%, Missing); spleen: 72.4138% (minimum 95%, Missing); stomach: 80.7692% (minimum 97%, Missing); thymus: 32.8125% (minimum 95%, Missing); urinary bladder: 87.5000% (minimum 97%, Missing)",-0.621875,-0.5325,-0.7275,0,80,unavailable,5.9,2.7,4.3,"bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000051341,POLQ,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.2500% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); esophagus: 52.5000% (minimum 70%, Missing); lymph node: 43.7500% (minimum 70%, Missing); rectum: 52.5000% (minimum 70%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 70.0000% (minimum 75%, Missing); thymus: 32.8125% (minimum 65%, Missing)",-0.321875,-0.2625,-0.4875,0,80,unavailable,5.9,2.7,4.3,"bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000051341,POLQ,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.2500% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); esophagus: 52.5000% (minimum 70%, Missing); lymph node: 43.7500% (minimum 70%, Missing); rectum: 52.5000% (minimum 70%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 70.0000% (minimum 75%, Missing); thymus: 32.8125% (minimum 65%, Missing)",-0.321875,-0.2625,-0.4875,0,80,unavailable,5.9,2.7,4.3,"bone marrow: 5.9 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000051341,POLQ,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.2500% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); esophagus: 52.5000% (minimum 70%, Missing); lymph node: 43.7500% (minimum 70%, Missing); rectum: 52.5000% (minimum 70%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 70.0000% (minimum 75%, Missing); thymus: 32.8125% (minimum 65%, Missing)",-0.321875,-0.2625,-0.4875,0,80,unavailable,5.9,2.7,4.3,"bone marrow: 5.9 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000051341,POLQ,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.2500% (minimum 75%, Baseline (adaptation disabled)); colon: 63.6364% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.6250% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.5000% (minimum 70%, Baseline (adaptation disabled)); lymph node: 43.7500% (minimum 70%, Baseline (adaptation disabled)); rectum: 52.5000% (minimum 70%, Baseline (adaptation disabled)); skin: 60.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 70.0000% (minimum 75%, Baseline (adaptation disabled)); thymus: 32.8125% (minimum 65%, Baseline (adaptation disabled))",-0.321875,-0.2625,-0.4875,0,80,unavailable,5.9,2.7,4.3,"bone marrow: 5.9 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000051341,POLQ,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000054796,SPO11,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000054796,SPO11,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000054796,SPO11,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000054796,SPO11,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000054796,SPO11,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.6173% (minimum 60%, Enhanced); adrenal gland: 18.6364% (minimum 95%, Enhanced); amygdala: 68.3333% (minimum 99%, Missing); basal ganglia: 60.2941% (minimum 99%, Missing); bone marrow: 29.2857% (minimum 95%, Enhanced); cerebellum: 53.9474% (minimum 95%, Enhanced); cerebral cortex: 56.1644% (minimum 95%, Enhanced); choroid plexus: 60.2941% (minimum 99%, Missing); colon: 53.9474% (minimum 80%, Enhanced); duodenum: 82.0000% (minimum 95%, Enhanced); esophagus: 74.5455% (minimum 80%, Enhanced); heart muscle: 56.9444% (minimum 95%, Enhanced); hippocampal formation: 69.4915% (minimum 99%, Missing); hypothalamus: 70.6897% (minimum 99%, Missing); kidney: 44.0860% (minimum 95%, Enhanced); liver: 0.2263% (minimum 95%, Enhanced); lung: 46.5909% (minimum 95%, Enhanced); lymph node: 71.9298% (minimum 80%, Enhanced); midbrain: 67.2131% (minimum 99%, Missing); pancreas: 7.9457% (minimum 95%, Enhanced); pituitary gland: 49.3976% (minimum 99%, Missing); retina: 56.1644% (minimum 99%, Missing); salivary gland: 67.2131% (minimum 80%, Enhanced); skeletal muscle: 9.5571% (minimum 95%, Enhanced); small intestine: 55.4054% (minimum 95%, Enhanced); smooth muscle: 74.5455% (minimum 95%, Enhanced); spinal cord: 74.5455% (minimum 99%, Missing); spleen: 36.2832% (minimum 60%, Enhanced); stomach: 52.5641% (minimum 80%, Enhanced); thymus: 66.1290% (minimum 95%, Missing); thyroid gland: 44.5652% (minimum 60%, Enhanced); tongue: 60.2941% (minimum 97%, Missing); urinary bladder: 44.5652% (minimum 80%, Enhanced)",-0.28871,-0.367059,-0.947737,0,1,partial,1807.4,5.1,7.2,"liver: 1807.4 nTPM (vital, limit 6); pancreas: 47.5 nTPM (vital, limit 6); skeletal muscle: 38.8 nTPM (vital, limit 6); adrenal gland: 17.9 nTPM (vital, limit 6); bone marrow: 9.9 nTPM (vital, limit 6); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000055955,ITIH4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 18.6364% (minimum 60%, Enhanced); amygdala: 68.3333% (minimum 75%, Missing); basal ganglia: 60.2941% (minimum 75%, Missing); bone marrow: 29.2857% (minimum 60%, Enhanced); cerebellum: 53.9474% (minimum 60%, Enhanced); cerebral cortex: 56.1644% (minimum 60%, Enhanced); choroid plexus: 60.2941% (minimum 75%, Missing); colon: 53.9474% (minimum 55%, Enhanced); heart muscle: 56.9444% (minimum 60%, Enhanced); hippocampal formation: 69.4915% (minimum 75%, Missing); hypothalamus: 70.6897% (minimum 75%, Missing); kidney: 44.0860% (minimum 60%, Enhanced); liver: 0.2263% (minimum 60%, Enhanced); lung: 46.5909% (minimum 60%, Enhanced); midbrain: 67.2131% (minimum 75%, Missing); pancreas: 7.9457% (minimum 60%, Enhanced); pituitary gland: 49.3976% (minimum 75%, Missing); retina: 56.1644% (minimum 75%, Missing); skeletal muscle: 9.5571% (minimum 60%, Enhanced); small intestine: 55.4054% (minimum 60%, Enhanced); spinal cord: 74.5455% (minimum 75%, Missing); spleen: 36.2832% (minimum 50%, Enhanced); stomach: 52.5641% (minimum 55%, Enhanced); thyroid gland: 44.5652% (minimum 50%, Enhanced); tongue: 60.2941% (minimum 70%, Missing); urinary bladder: 44.5652% (minimum 55%, Enhanced)",-0.137168,-0.104348,-0.597737,0,1,partial,1807.4,5.1,7.2,"liver: 1807.4 nTPM (vital, limit 6); pancreas: 47.5 nTPM (vital, limit 6); skeletal muscle: 38.8 nTPM (vital, limit 6); adrenal gland: 17.9 nTPM (vital, limit 6); bone marrow: 9.9 nTPM (vital, limit 6); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000055955,ITIH4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 18.6364% (minimum 60%, Enhanced); amygdala: 68.3333% (minimum 75%, Missing); basal ganglia: 60.2941% (minimum 75%, Missing); bone marrow: 29.2857% (minimum 60%, Enhanced); cerebellum: 53.9474% (minimum 60%, Enhanced); cerebral cortex: 56.1644% (minimum 60%, Enhanced); choroid plexus: 60.2941% (minimum 75%, Missing); colon: 53.9474% (minimum 55%, Enhanced); heart muscle: 56.9444% (minimum 60%, Enhanced); hippocampal formation: 69.4915% (minimum 75%, Missing); hypothalamus: 70.6897% (minimum 75%, Missing); kidney: 44.0860% (minimum 60%, Enhanced); liver: 0.2263% (minimum 60%, Enhanced); lung: 46.5909% (minimum 60%, Enhanced); midbrain: 67.2131% (minimum 75%, Missing); pancreas: 7.9457% (minimum 60%, Enhanced); pituitary gland: 49.3976% (minimum 75%, Missing); retina: 56.1644% (minimum 75%, Missing); skeletal muscle: 9.5571% (minimum 60%, Enhanced); small intestine: 55.4054% (minimum 60%, Enhanced); spinal cord: 74.5455% (minimum 75%, Missing); spleen: 36.2832% (minimum 50%, Enhanced); stomach: 52.5641% (minimum 55%, Enhanced); thyroid gland: 44.5652% (minimum 50%, Enhanced); tongue: 60.2941% (minimum 70%, Missing); urinary bladder: 44.5652% (minimum 55%, Enhanced)",-0.137168,-0.104348,-0.597737,0,1,partial,1807.4,5.1,7.2,"liver: 1807.4 nTPM (vital, limit 6); pancreas: 47.5 nTPM (vital, limit 6); skeletal muscle: 38.8 nTPM (vital, limit 6); adrenal gland: 17.9 nTPM (vital, limit 6); bone marrow: 9.9 nTPM (vital, limit 6); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000055955,ITIH4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 18.6364% (minimum 60%, Enhanced); amygdala: 68.3333% (minimum 75%, Missing); basal ganglia: 60.2941% (minimum 75%, Missing); bone marrow: 29.2857% (minimum 60%, Enhanced); cerebellum: 53.9474% (minimum 60%, Enhanced); cerebral cortex: 56.1644% (minimum 60%, Enhanced); choroid plexus: 60.2941% (minimum 75%, Missing); colon: 53.9474% (minimum 55%, Enhanced); heart muscle: 56.9444% (minimum 60%, Enhanced); hippocampal formation: 69.4915% (minimum 75%, Missing); hypothalamus: 70.6897% (minimum 75%, Missing); kidney: 44.0860% (minimum 60%, Enhanced); liver: 0.2263% (minimum 60%, Enhanced); lung: 46.5909% (minimum 60%, Enhanced); midbrain: 67.2131% (minimum 75%, Missing); pancreas: 7.9457% (minimum 60%, Enhanced); pituitary gland: 49.3976% (minimum 75%, Missing); retina: 56.1644% (minimum 75%, Missing); skeletal muscle: 9.5571% (minimum 60%, Enhanced); small intestine: 55.4054% (minimum 60%, Enhanced); spinal cord: 74.5455% (minimum 75%, Missing); spleen: 36.2832% (minimum 50%, Enhanced); stomach: 52.5641% (minimum 55%, Enhanced); thyroid gland: 44.5652% (minimum 50%, Enhanced); tongue: 60.2941% (minimum 70%, Missing); urinary bladder: 44.5652% (minimum 55%, Enhanced)",-0.137168,-0.104348,-0.597737,0,1,partial,1807.4,5.1,7.2,"liver: 1807.4 nTPM (vital, limit 6); pancreas: 47.5 nTPM (vital, limit 6); skeletal muscle: 38.8 nTPM (vital, limit 6); adrenal gland: 17.9 nTPM (vital, limit 6); bone marrow: 9.9 nTPM (vital, limit 6); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000055955,ITIH4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.6173% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 18.6364% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.2941% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 29.2857% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 53.9474% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.1644% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.2941% (minimum 75%, Baseline (adaptation disabled)); colon: 53.9474% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 56.9444% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 69.4915% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 70.6897% (minimum 75%, Baseline (adaptation disabled)); kidney: 44.0860% (minimum 75%, Baseline (adaptation disabled)); liver: 0.2263% (minimum 75%, Baseline (adaptation disabled)); lung: 46.5909% (minimum 75%, Baseline (adaptation disabled)); midbrain: 67.2131% (minimum 75%, Baseline (adaptation disabled)); pancreas: 7.9457% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 49.3976% (minimum 75%, Baseline (adaptation disabled)); retina: 56.1644% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 67.2131% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 9.5571% (minimum 75%, Baseline (adaptation disabled)); skin: 63.0769% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.4054% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 74.5455% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.5455% (minimum 75%, Baseline (adaptation disabled)); spleen: 36.2832% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.5641% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 44.5652% (minimum 65%, Baseline (adaptation disabled)); tongue: 60.2941% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 44.5652% (minimum 70%, Baseline (adaptation disabled))",-0.287168,-0.254348,-0.747737,0,1,partial,1807.4,5.1,7.2,"liver: 1807.4 nTPM (vital, limit 1); pancreas: 47.5 nTPM (vital, limit 1); skeletal muscle: 38.8 nTPM (vital, limit 1); adrenal gland: 17.9 nTPM (vital, limit 1); bone marrow: 9.9 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 3); lung: 4.7 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000055955,ITIH4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 86.6667% (minimum 99%, Missing); amygdala: 90.0990% (minimum 99%, Missing); basal ganglia: 91.0000% (minimum 99%, Missing); bone marrow: 77.7778% (minimum 99%, Missing); cerebellum: 85.8491% (minimum 99%, Missing); cerebral cortex: 85.8491% (minimum 99%, Missing); choroid plexus: 94.7917% (minimum 99%, Missing); colon: 86.6667% (minimum 97%, Missing); duodenum: 87.5000% (minimum 99%, Missing); esophagus: 87.5000% (minimum 97%, Missing); heart muscle: 91.0000% (minimum 99%, Missing); hippocampal formation: 90.0990% (minimum 99%, Missing); hypothalamus: 88.3495% (minimum 99%, Missing); kidney: 89.2157% (minimum 99%, Missing); liver: 88.3495% (minimum 99%, Missing); lung: 86.6667% (minimum 99%, Missing); lymph node: 80.5310% (minimum 97%, Missing); midbrain: 90.0990% (minimum 99%, Missing); pancreas: 88.3495% (minimum 99%, Missing); parathyroid gland: 85.0467% (minimum 97%, Missing); pituitary gland: 85.8491% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 83.4862% (minimum 99%, Missing); salivary gland: 89.2157% (minimum 97%, Missing); skeletal muscle: 87.5000% (minimum 99%, Missing); skin: 85.0467% (minimum 95%, Missing); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 84.2593% (minimum 99%, Missing); spinal cord: 88.3495% (minimum 99%, Missing); spleen: 85.0467% (minimum 95%, Missing); stomach: 89.2157% (minimum 97%, Missing); thymus: 81.2500% (minimum 95%, Missing); thyroid gland: 85.8491% (minimum 95%, Missing); tongue: 90.0990% (minimum 97%, Missing); urinary bladder: 85.8491% (minimum 97%, Missing)",-0.1375,-0.16469,-0.212222,0,2,partial,2.6,2.2,2.1,"bone marrow: 2.6 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000056277,ZNF280C,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.1625,0.10531,0.0277778,0,2,partial,2.6,2.2,2.1,"bone marrow: 2.6 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000056277,ZNF280C,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.1625,0.10531,0.0277778,0,2,partial,2.6,2.2,2.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000056277,ZNF280C,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.1625,0.10531,0.0277778,0,2,partial,2.6,2.2,2.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000056277,ZNF280C,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.1625,0.10531,0.0277778,0,2,partial,2.6,2.2,2.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000056277,ZNF280C,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 93.9394% (minimum 99%, Missing); basal ganglia: 93.9394% (minimum 99%, Missing); cerebral cortex: 91.1765% (minimum 99%, Missing); colon: 96.8750% (minimum 97%, Missing); duodenum: 96.8750% (minimum 99%, Missing); hypothalamus: 88.5714% (minimum 99%, Missing); lymph node: 96.8750% (minimum 97%, Missing); pituitary gland: 96.8750% (minimum 99%, Missing); rectum: 93.9394% (minimum 97%, Missing); retina: 81.5789% (minimum 99%, Missing); thymus: 30.6931% (minimum 95%, Missing); thyroid gland: 88.5714% (minimum 95%, Missing); tongue: 93.9394% (minimum 97%, Missing); urinary bladder: 88.5714% (minimum 97%, Missing)",-0.643069,-0.0842857,-0.174211,0,80,unavailable,0.7,0.4,7,"thymus: 7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000056291,NPFFR2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 30.6931% (minimum 65%, Missing)",-0.343069,0.185714,0.0657895,0,80,unavailable,0.7,0.4,7,"thymus: 7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000056291,NPFFR2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 30.6931% (minimum 65%, Missing)",-0.343069,0.185714,0.0657895,0,80,unavailable,0.7,0.4,7,"thymus: 7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000056291,NPFFR2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 30.6931% (minimum 65%, Missing)",-0.343069,0.185714,0.0657895,0,80,unavailable,0.7,0.4,7,"thymus: 7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000056291,NPFFR2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 30.6931% (minimum 65%, Baseline (adaptation disabled))",-0.343069,0.185714,0.0657895,0,80,unavailable,0.7,0.4,7,"thymus: 7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000056291,NPFFR2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.6190% (minimum 99%, Missing); amygdala: 97.6190% (minimum 99%, Missing); basal ganglia: 97.6190% (minimum 99%, Missing); bone marrow: 97.6190% (minimum 99%, Missing); cerebellum: 80.3922% (minimum 99%, Missing); cerebral cortex: 95.3488% (minimum 99%, Missing); colon: 93.1818% (minimum 97%, Missing); heart muscle: 93.1818% (minimum 99%, Missing); hippocampal formation: 97.6190% (minimum 99%, Missing); hypothalamus: 97.6190% (minimum 99%, Missing); kidney: 97.6190% (minimum 99%, Missing); liver: 97.6190% (minimum 99%, Missing); lung: 95.3488% (minimum 99%, Missing); midbrain: 97.6190% (minimum 99%, Missing); pancreas: 97.6190% (minimum 99%, Missing); retina: 87.2340% (minimum 99%, Missing); skeletal muscle: 85.4167% (minimum 99%, Missing); small intestine: 95.3488% (minimum 99%, Missing); smooth muscle: 97.6190% (minimum 99%, Missing); spinal cord: 95.3488% (minimum 99%, Missing); spleen: 89.1304% (minimum 95%, Missing); urinary bladder: 93.1818% (minimum 97%, Missing)",-0.0586957,-0.0381818,-0.186078,0,80,unavailable,1,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000057468,MSH4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.241304,0.231818,0.0539216,0,80,unavailable,1,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000057468,MSH4,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.241304,0.231818,0.0539216,0,80,unavailable,1,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000057468,MSH4,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.241304,0.231818,0.0539216,0,80,unavailable,1,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000057468,MSH4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.241304,0.231818,0.0539216,0,80,unavailable,1,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000057468,MSH4,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.0225% (minimum 90%, Approved); adrenal gland: 71.5686% (minimum 99%, Missing); amygdala: 76.8421% (minimum 99%, Missing); basal ganglia: 76.8421% (minimum 99%, Missing); cerebellum: 56.1538% (minimum 99%, Missing); cerebral cortex: 72.2772% (minimum 99%, Missing); choroid plexus: 79.3478% (minimum 99%, Missing); colon: 71.5686% (minimum 97%, Missing); duodenum: 74.4898% (minimum 99%, Missing); esophagus: 74.4898% (minimum 95%, Approved); heart muscle: 68.8679% (minimum 99%, Missing); hippocampal formation: 75.2577% (minimum 99%, Missing); hypothalamus: 75.2577% (minimum 99%, Missing); kidney: 73.0000% (minimum 99%, Missing); liver: 82.9545% (minimum 98%, Approved); lung: 75.2577% (minimum 99%, Missing); lymph node: 90.1235% (minimum 95%, Approved); midbrain: 74.4898% (minimum 99%, Missing); pancreas: 75.2577% (minimum 98%, Approved); parathyroid gland: 62.9310% (minimum 97%, Missing); pituitary gland: 68.8679% (minimum 99%, Missing); rectum: 72.2772% (minimum 95%, Approved); retina: 59.3496% (minimum 99%, Missing); salivary gland: 71.5686% (minimum 97%, Missing); skeletal muscle: 80.2198% (minimum 99%, Missing); skin: 73.0000% (minimum 90%, Approved); small intestine: 73.7374% (minimum 99%, Missing); smooth muscle: 73.0000% (minimum 99%, Missing); spinal cord: 72.2772% (minimum 99%, Missing); spleen: 78.4946% (minimum 90%, Approved); stomach: 70.1923% (minimum 95%, Approved); thymus: 83.9080% (minimum 95%, Missing); thyroid gland: 64.6018% (minimum 90%, Approved); tongue: 75.2577% (minimum 97%, Missing); urinary bladder: 76.8421% (minimum 95%, Approved)",-0.253982,-0.34069,-0.428462,0,0,routine_complete,5.7,4.3,4,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); salivary gland: 2.9 nTPM (protected, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 2); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000062370,ZNF112,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.5686% (minimum 75%, Missing); cerebellum: 56.1538% (minimum 75%, Missing); cerebral cortex: 72.2772% (minimum 75%, Missing); duodenum: 74.4898% (minimum 75%, Missing); heart muscle: 68.8679% (minimum 75%, Missing); kidney: 73.0000% (minimum 75%, Missing); midbrain: 74.4898% (minimum 75%, Missing); parathyroid gland: 62.9310% (minimum 70%, Missing); pituitary gland: 68.8679% (minimum 75%, Missing); retina: 59.3496% (minimum 75%, Missing); small intestine: 73.7374% (minimum 75%, Missing); smooth muscle: 73.0000% (minimum 75%, Missing); spinal cord: 72.2772% (minimum 75%, Missing)",0.0460177,-0.0706897,-0.188462,0,0,routine_complete,5.7,4.3,4,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); salivary gland: 2.9 nTPM (protected, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 2); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000062370,ZNF112,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.5686% (minimum 75%, Missing); cerebellum: 56.1538% (minimum 75%, Missing); cerebral cortex: 72.2772% (minimum 75%, Missing); duodenum: 74.4898% (minimum 75%, Missing); heart muscle: 68.8679% (minimum 75%, Missing); kidney: 73.0000% (minimum 75%, Missing); midbrain: 74.4898% (minimum 75%, Missing); parathyroid gland: 62.9310% (minimum 70%, Missing); pituitary gland: 68.8679% (minimum 75%, Missing); retina: 59.3496% (minimum 75%, Missing); small intestine: 73.7374% (minimum 75%, Missing); smooth muscle: 73.0000% (minimum 75%, Missing); spinal cord: 72.2772% (minimum 75%, Missing)",0.0460177,-0.0706897,-0.188462,0,0,routine_complete,5.7,4.3,4,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 2); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000062370,ZNF112,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.5686% (minimum 75%, Missing); cerebellum: 56.1538% (minimum 75%, Missing); cerebral cortex: 72.2772% (minimum 75%, Missing); duodenum: 74.4898% (minimum 75%, Missing); heart muscle: 68.8679% (minimum 75%, Missing); kidney: 73.0000% (minimum 75%, Missing); midbrain: 74.4898% (minimum 75%, Missing); parathyroid gland: 62.9310% (minimum 70%, Missing); pituitary gland: 68.8679% (minimum 75%, Missing); retina: 59.3496% (minimum 75%, Missing); small intestine: 73.7374% (minimum 75%, Missing); smooth muscle: 73.0000% (minimum 75%, Missing); spinal cord: 72.2772% (minimum 75%, Missing)",0.0460177,-0.0706897,-0.188462,0,0,routine_complete,5.7,4.3,4,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 2); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000062370,ZNF112,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.5686% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.1538% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.2772% (minimum 75%, Baseline (adaptation disabled)); duodenum: 74.4898% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 68.8679% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 74.4898% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.9310% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 68.8679% (minimum 75%, Baseline (adaptation disabled)); retina: 59.3496% (minimum 75%, Baseline (adaptation disabled)); small intestine: 73.7374% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.2772% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 64.6018% (minimum 65%, Baseline (adaptation disabled))",-0.0039823,-0.0706897,-0.188462,0,0,routine_complete,5.7,4.3,4,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); adrenal gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000062370,ZNF112,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9636% (minimum 99%, Missing); amygdala: 98.3854% (minimum 99%, Missing); basal ganglia: 98.1740% (minimum 99%, Missing); bone marrow: 96.0084% (minimum 99%, Missing); choroid plexus: 85.5005% (minimum 99%, Missing); colon: 96.1094% (minimum 97%, Missing); heart muscle: 97.4414% (minimum 99%, Missing); hippocampal formation: 98.3854% (minimum 99%, Missing); hypothalamus: 98.3854% (minimum 99%, Missing); kidney: 91.6750% (minimum 99%, Missing); liver: 90.4055% (minimum 99%, Missing); lung: 95.0104% (minimum 99%, Missing); lymph node: 93.1702% (minimum 97%, Missing); midbrain: 98.8108% (minimum 99%, Missing); pancreas: 93.1702% (minimum 99%, Missing); pituitary gland: 98.3854% (minimum 99%, Missing); retina: 95.0104% (minimum 99%, Missing); skeletal muscle: 98.9177% (minimum 99%, Missing); small intestine: 96.2105% (minimum 99%, Missing); smooth muscle: 98.1740% (minimum 99%, Missing); stomach: 96.4135% (minimum 97%, Missing); urinary bladder: 96.3119% (minimum 97%, Missing)",0.00208333,-0.0382977,-0.134995,0,80,unavailable,15.5,6.7,4.6,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 2); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063127,SLC6A16,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302083,0.231702,0.105005,0,80,unavailable,15.5,6.7,4.6,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 2); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063127,SLC6A16,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302083,0.231702,0.105005,0,80,unavailable,15.5,6.7,4.6,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 3); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); stomach: 3.4 nTPM (protected, limit 3); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063127,SLC6A16,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302083,0.231702,0.105005,0,80,unavailable,15.5,6.7,4.6,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 3); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); stomach: 3.4 nTPM (protected, limit 3); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063127,SLC6A16,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302083,0.231702,0.105005,0,80,unavailable,15.5,6.7,4.6,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 3); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); stomach: 3.4 nTPM (protected, limit 3); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063127,SLC6A16,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4716% (minimum 99%, Missing); amygdala: 97.1983% (minimum 99%, Missing); basal ganglia: 98.4716% (minimum 99%, Missing); cerebral cortex: 95.5508% (minimum 99%, Missing); colon: 95.7537% (minimum 97%, Missing); duodenum: 98.4716% (minimum 99%, Missing); esophagus: 95.3488% (minimum 97%, Missing); heart muscle: 98.9035% (minimum 99%, Missing); hippocampal formation: 96.5739% (minimum 99%, Missing); hypothalamus: 97.1983% (minimum 99%, Missing); kidney: 96.7811% (minimum 99%, Missing); liver: 98.6871% (minimum 99%, Missing); lung: 95.5508% (minimum 99%, Missing); pancreas: 98.6871% (minimum 99%, Missing); pituitary gland: 96.7811% (minimum 99%, Missing); skeletal muscle: 98.9035% (minimum 99%, Missing); skin: 88.6051% (minimum 95%, Missing); small intestine: 96.1620% (minimum 99%, Missing); spleen: 88.9546% (minimum 95%, Missing); urinary bladder: 93.1818% (minimum 97%, Missing)",-0.0639489,-0.0381818,-0.0344915,0,80,unavailable,2.1,3.3,5.8,"skin: 5.8 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063438,AHRR,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.236051,0.231818,0.205508,0,80,unavailable,2.1,3.3,5.8,"skin: 5.8 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063438,AHRR,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.236051,0.231818,0.205508,0,80,unavailable,2.1,3.3,5.8,"skin: 5.8 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 3); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063438,AHRR,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.236051,0.231818,0.205508,0,80,unavailable,2.1,3.3,5.8,"skin: 5.8 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 3); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063438,AHRR,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.236051,0.231818,0.205508,0,80,unavailable,2.1,3.3,5.8,"skin: 5.8 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 3); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063438,AHRR,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 68.7500% (minimum 99%, Missing)",0.05,0.03,-0.3025,0,0,routine_complete,1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063515,GSC2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 68.7500% (minimum 75%, Missing)",0.35,0.3,-0.0625,0,0,routine_complete,1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063515,GSC2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 68.7500% (minimum 75%, Missing)",0.35,0.3,-0.0625,0,0,routine_complete,1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063515,GSC2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 68.7500% (minimum 75%, Missing)",0.35,0.3,-0.0625,0,0,routine_complete,1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063515,GSC2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 68.7500% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.0625,0,0,routine_complete,1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000063515,GSC2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 94.9324% (minimum 99%, Missing); basal ganglia: 94.3745% (minimum 99%, Missing); choroid plexus: 93.6667% (minimum 99%, Missing); hippocampal formation: 94.6925% (minimum 99%, Missing); hypothalamus: 93.3167% (minimum 99%, Missing); kidney: 95.2139% (minimum 99%, Missing); midbrain: 95.9863% (minimum 99%, Missing); pituitary gland: 94.4935% (minimum 99%, Missing); spinal cord: 97.5271% (minimum 99%, Missing)",0.0390013,0.0291111,-0.0568327,0,9,partial,16.1,5.2,8.6,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 6); midbrain: 9.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); spinal cord: 5.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000064199,SPA17,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.339001,0.299111,0.183167,0,9,partial,16.1,5.2,8.6,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 6); midbrain: 9.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); spinal cord: 5.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000064199,SPA17,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.339001,0.299111,0.183167,0,9,partial,16.1,5.2,8.6,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 6); midbrain: 9.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); spinal cord: 5.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000064199,SPA17,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.339001,0.299111,0.183167,0,9,partial,16.1,5.2,8.6,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 6); midbrain: 9.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); spinal cord: 5.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000064199,SPA17,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.313153,0.277391,0.183167,0,9,partial,16.1,5.2,8.6,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); thyroid gland: 8.6 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 3); esophagus: 4.9 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 3); heart muscle: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); urinary bladder: 3.1 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000064199,SPA17,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.6131% (minimum 95%, Enhanced); amygdala: 95.8879% (minimum 99%, Missing); basal ganglia: 95.7090% (minimum 99%, Missing); cerebellum: 93.9560% (minimum 95%, Enhanced); choroid plexus: 98.2759% (minimum 99%, Missing); colon: 93.1034% (minimum 97%, Missing); esophagus: 94.1284% (minimum 97%, Missing); heart muscle: 93.6131% (minimum 95%, Enhanced); hippocampal formation: 96.0674% (minimum 99%, Missing); hypothalamus: 96.0674% (minimum 99%, Missing); kidney: 94.6494% (minimum 95%, Enhanced); lung: 94.3015% (minimum 95%, Enhanced); lymph node: 94.6494% (minimum 97%, Missing); midbrain: 96.7925% (minimum 99%, Missing); pancreas: 93.6131% (minimum 95%, Enhanced); pituitary gland: 96.6102% (minimum 99%, Missing); rectum: 96.4286% (minimum 97%, Missing); retina: 98.4645% (minimum 99%, Missing); skeletal muscle: 85.7860% (minimum 95%, Enhanced); small intestine: 92.4324% (minimum 99%, Missing); spinal cord: 97.1591% (minimum 99%, Missing); stomach: 93.2727% (minimum 97%, Missing); thymus: 93.4426% (minimum 95%, Missing); tongue: 96.7925% (minimum 97%, Missing); urinary bladder: 93.1034% (minimum 97%, Missing)",-0.0155738,-0.0389655,-0.0921405,0,1,partial,8.5,3.8,4.7,"skeletal muscle: 8.5 nTPM (vital, limit 6); small intestine: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); urinary bladder: 3.8 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000064703,DDX20,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.284426,0.231034,0.174324,0,1,partial,8.5,3.8,4.7,"skeletal muscle: 8.5 nTPM (vital, limit 6); small intestine: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); urinary bladder: 3.8 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000064703,DDX20,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.284426,0.231034,0.174324,0,1,partial,8.5,3.8,4.7,"skeletal muscle: 8.5 nTPM (vital, limit 6); small intestine: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); urinary bladder: 3.8 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000064703,DDX20,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.284426,0.231034,0.174324,0,1,partial,8.5,3.8,4.7,"skeletal muscle: 8.5 nTPM (vital, limit 6); small intestine: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); urinary bladder: 3.8 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000064703,DDX20,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.266071,0.231034,0.10786,0,1,partial,8.5,3.8,4.7,"skeletal muscle: 8.5 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); colon: 3.8 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000064703,DDX20,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 90%, Approved); adrenal gland: 95.2381% (minimum 98%, Approved); bone marrow: 18.0180% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 98%, Approved); colon: 54.0541% (minimum 95%, Approved); duodenum: 57.1429% (minimum 98%, Approved); esophagus: 51.2821% (minimum 95%, Approved); heart muscle: 95.2381% (minimum 98%, Approved); hypothalamus: 95.2381% (minimum 99%, Missing); kidney: 95.2381% (minimum 98%, Approved); liver: 74.0741% (minimum 98%, Approved); lung: 86.9565% (minimum 98%, Approved); lymph node: 29.8507% (minimum 97%, Missing); pancreas: 95.2381% (minimum 98%, Approved); parathyroid gland: 90.9091% (minimum 95%, Approved); pituitary gland: 95.2381% (minimum 99%, Missing); rectum: 48.7805% (minimum 95%, Approved); retina: 95.2381% (minimum 99%, Missing); salivary gland: 86.9565% (minimum 95%, Approved); skeletal muscle: 80.0000% (minimum 98%, Approved); skin: 64.5161% (minimum 90%, Approved); small intestine: 62.5000% (minimum 98%, Approved); smooth muscle: 71.4286% (minimum 98%, Approved); spleen: 68.9655% (minimum 95%, Missing); stomach: 71.4286% (minimum 95%, Approved); thymus: 20.2020% (minimum 95%, Missing); thyroid gland: 86.9565% (minimum 90%, Approved); tongue: 95.2381% (minimum 97%, Missing); urinary bladder: 76.9231% (minimum 95%, Approved)",-0.74798,-0.671493,-0.80982,0,0,routine_complete,9.1,4.7,7.9,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065328,MCM10,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 18.0180% (minimum 75%, Missing); colon: 54.0541% (minimum 65%, Approved); duodenum: 57.1429% (minimum 70%, Approved); esophagus: 51.2821% (minimum 65%, Approved); lymph node: 29.8507% (minimum 70%, Missing); rectum: 48.7805% (minimum 65%, Approved); small intestine: 62.5000% (minimum 70%, Approved); thymus: 20.2020% (minimum 65%, Missing)",-0.44798,-0.401493,-0.56982,0,0,routine_complete,9.1,4.7,7.9,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065328,MCM10,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 18.0180% (minimum 75%, Missing); colon: 54.0541% (minimum 65%, Approved); duodenum: 57.1429% (minimum 70%, Approved); esophagus: 51.2821% (minimum 65%, Approved); lymph node: 29.8507% (minimum 70%, Missing); rectum: 48.7805% (minimum 65%, Approved); small intestine: 62.5000% (minimum 70%, Approved); thymus: 20.2020% (minimum 65%, Missing)",-0.44798,-0.401493,-0.56982,0,0,routine_complete,9.1,4.7,7.9,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065328,MCM10,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 18.0180% (minimum 75%, Missing); colon: 54.0541% (minimum 65%, Approved); duodenum: 57.1429% (minimum 70%, Approved); esophagus: 51.2821% (minimum 65%, Approved); lymph node: 29.8507% (minimum 70%, Missing); rectum: 48.7805% (minimum 65%, Approved); small intestine: 62.5000% (minimum 70%, Approved); thymus: 20.2020% (minimum 65%, Missing)",-0.44798,-0.401493,-0.56982,0,0,routine_complete,9.1,4.7,7.9,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065328,MCM10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 18.0180% (minimum 75%, Baseline (adaptation disabled)); colon: 54.0541% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.1429% (minimum 75%, Baseline (adaptation disabled)); esophagus: 51.2821% (minimum 70%, Baseline (adaptation disabled)); liver: 74.0741% (minimum 75%, Baseline (adaptation disabled)); lymph node: 29.8507% (minimum 70%, Baseline (adaptation disabled)); rectum: 48.7805% (minimum 70%, Baseline (adaptation disabled)); skin: 64.5161% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.5000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); thymus: 20.2020% (minimum 65%, Baseline (adaptation disabled))",-0.44798,-0.401493,-0.56982,0,0,routine_complete,9.1,4.7,7.9,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 3); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065328,MCM10,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.0267721,0.00806076,0,3,partial,0.6,6,1.5,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065371,ROPN1,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296772,0.248061,0,3,partial,0.6,6,1.5,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065371,ROPN1,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296772,0.248061,0,3,partial,0.6,6,1.5,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065371,ROPN1,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296772,0.248061,0,3,partial,0.6,6,1.5,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065371,ROPN1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340378,0.262594,0.246129,0,3,partial,0.6,6,1.5,"salivary gland: 6 nTPM (protected, limit 3)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065371,ROPN1,current_fixed,True,False,False,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.8247% (minimum 95%, Enhanced); amygdala: 22.4762% (minimum 99%, Missing); basal ganglia: 28.1623% (minimum 99%, Missing); cerebellum: 9.6405% (minimum 99%, Missing); cerebral cortex: 11.6832% (minimum 99%, Missing); choroid plexus: 54.1284% (minimum 99%, Missing); colon: 90.7692% (minimum 97%, Missing); heart muscle: 94.4000% (minimum 95%, Enhanced); hippocampal formation: 21.3382% (minimum 99%, Missing); hypothalamus: 20.3098% (minimum 99%, Missing); midbrain: 28.3654% (minimum 99%, Missing); pancreas: 88.7218% (minimum 95%, Enhanced); pituitary gland: 31.9783% (minimum 99%, Missing); retina: 11.7063% (minimum 99%, Missing); small intestine: 93.6508% (minimum 95%, Enhanced); smooth muscle: 94.4000% (minimum 95%, Enhanced); spinal cord: 38.9439% (minimum 99%, Missing); tongue: 89.3939% (minimum 97%, Missing)",0.0252066,-0.0760606,-0.893595,0,5,partial,110.6,2.9,1.3,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 6)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065609,SNAP91,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 22.4762% (minimum 75%, Missing); basal ganglia: 28.1623% (minimum 75%, Missing); cerebellum: 9.6405% (minimum 75%, Missing); cerebral cortex: 11.6832% (minimum 75%, Missing); choroid plexus: 54.1284% (minimum 75%, Missing); hippocampal formation: 21.3382% (minimum 75%, Missing); hypothalamus: 20.3098% (minimum 75%, Missing); midbrain: 28.3654% (minimum 75%, Missing); pituitary gland: 31.9783% (minimum 75%, Missing); retina: 11.7063% (minimum 75%, Missing); spinal cord: 38.9439% (minimum 75%, Missing)",0.325207,0.193939,-0.653595,0,5,partial,110.6,2.9,1.3,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 6)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065609,SNAP91,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 22.4762% (minimum 75%, Missing); basal ganglia: 28.1623% (minimum 75%, Missing); cerebellum: 9.6405% (minimum 75%, Missing); cerebral cortex: 11.6832% (minimum 75%, Missing); choroid plexus: 54.1284% (minimum 75%, Missing); hippocampal formation: 21.3382% (minimum 75%, Missing); hypothalamus: 20.3098% (minimum 75%, Missing); midbrain: 28.3654% (minimum 75%, Missing); pituitary gland: 31.9783% (minimum 75%, Missing); retina: 11.7063% (minimum 75%, Missing); spinal cord: 38.9439% (minimum 75%, Missing)",0.325207,0.193939,-0.653595,0,5,partial,110.6,2.9,1.3,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 6)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065609,SNAP91,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 22.4762% (minimum 75%, Missing); basal ganglia: 28.1623% (minimum 75%, Missing); cerebellum: 9.6405% (minimum 75%, Missing); cerebral cortex: 11.6832% (minimum 75%, Missing); choroid plexus: 54.1284% (minimum 75%, Missing); hippocampal formation: 21.3382% (minimum 75%, Missing); hypothalamus: 20.3098% (minimum 75%, Missing); midbrain: 28.3654% (minimum 75%, Missing); pituitary gland: 31.9783% (minimum 75%, Missing); retina: 11.7063% (minimum 75%, Missing); spinal cord: 38.9439% (minimum 75%, Missing)",0.325207,0.193939,-0.653595,0,5,partial,110.6,2.9,1.3,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 6)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065609,SNAP91,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.8247% (minimum 75%, Baseline (adaptation disabled)); amygdala: 22.4762% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 28.1623% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 9.6405% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 11.6832% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 54.1284% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 21.3382% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 20.3098% (minimum 75%, Baseline (adaptation disabled)); midbrain: 28.3654% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 31.9783% (minimum 75%, Baseline (adaptation disabled)); retina: 11.7063% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 38.9439% (minimum 75%, Baseline (adaptation disabled))",0.250763,0.102721,-0.653595,0,5,partial,110.6,2.9,1.3,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065609,SNAP91,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.0996% (minimum 95%, Uncertain); adrenal gland: 65.5172% (minimum 99%, Uncertain); amygdala: 77.3756% (minimum 99%, Missing); basal ganglia: 74.6725% (minimum 99%, Missing); bone marrow: 38.5135% (minimum 99%, Uncertain); cerebellum: 59.5819% (minimum 99%, Uncertain); cerebral cortex: 63.5688% (minimum 99%, Uncertain); choroid plexus: 68.4000% (minimum 99%, Missing); colon: 60.6383% (minimum 97%, Uncertain); duodenum: 63.0996% (minimum 99%, Missing); esophagus: 57.7703% (minimum 97%, Missing); heart muscle: 65.2672% (minimum 99%, Missing); hippocampal formation: 76.3393% (minimum 99%, Missing); hypothalamus: 76.0000% (minimum 99%, Missing); kidney: 59.5819% (minimum 99%, Missing); liver: 53.7736% (minimum 99%, Uncertain); lung: 61.2903% (minimum 99%, Uncertain); lymph node: 46.8493% (minimum 97%, Uncertain); midbrain: 77.7273% (minimum 99%, Missing); pancreas: 59.5819% (minimum 99%, Uncertain); parathyroid gland: 53.1056% (minimum 97%, Missing); pituitary gland: 68.9516% (minimum 99%, Missing); rectum: 58.5616% (minimum 97%, Missing); retina: 48.1690% (minimum 99%, Missing); salivary gland: 59.7902% (minimum 97%, Uncertain); skeletal muscle: 61.2903% (minimum 99%, Uncertain); skin: 60.2113% (minimum 95%, Missing); small intestine: 60.4240% (minimum 99%, Missing); smooth muscle: 61.7329% (minimum 99%, Uncertain); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 52.4540% (minimum 95%, Uncertain); stomach: 59.3750% (minimum 97%, Missing); thymus: 50.4425% (minimum 95%, Missing); thyroid gland: 47.7654% (minimum 95%, Uncertain); tongue: 57.5758% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",-0.472346,-0.501507,-0.604865,0,2,partial,27.3,19.4,18.7,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 2); thyroid gland: 18.7 nTPM (manageable, limit 5); retina: 18.4 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); spleen: 15.5 nTPM (manageable, limit 5); parathyroid gland: 15.1 nTPM (protected, limit 2); liver: 14.7 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 2); esophagus: 12.5 nTPM (protected, limit 2); rectum: 12.1 nTPM (protected, limit 2); stomach: 11.7 nTPM (protected, limit 2); cerebellum: 11.6 nTPM (vital, limit 1); pancreas: 11.6 nTPM (vital, limit 1); kidney: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); urinary bladder: 11.4 nTPM (protected, limit 2); skin: 11.3 nTPM (manageable, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 2); lung: 10.8 nTPM (vital, limit 1); skeletal muscle: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10 nTPM (manageable, limit 5); duodenum: 10 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065883,CDK13,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.0996% (minimum 65%, Uncertain); adrenal gland: 65.5172% (minimum 75%, Uncertain); basal ganglia: 74.6725% (minimum 75%, Missing); bone marrow: 38.5135% (minimum 75%, Uncertain); cerebellum: 59.5819% (minimum 75%, Uncertain); cerebral cortex: 63.5688% (minimum 75%, Uncertain); choroid plexus: 68.4000% (minimum 75%, Missing); colon: 60.6383% (minimum 70%, Uncertain); duodenum: 63.0996% (minimum 75%, Missing); esophagus: 57.7703% (minimum 70%, Missing); heart muscle: 65.2672% (minimum 75%, Missing); kidney: 59.5819% (minimum 75%, Missing); liver: 53.7736% (minimum 75%, Uncertain); lung: 61.2903% (minimum 75%, Uncertain); lymph node: 46.8493% (minimum 70%, Uncertain); pancreas: 59.5819% (minimum 75%, Uncertain); parathyroid gland: 53.1056% (minimum 70%, Missing); pituitary gland: 68.9516% (minimum 75%, Missing); rectum: 58.5616% (minimum 70%, Missing); retina: 48.1690% (minimum 75%, Missing); salivary gland: 59.7902% (minimum 70%, Uncertain); skeletal muscle: 61.2903% (minimum 75%, Uncertain); skin: 60.2113% (minimum 65%, Missing); small intestine: 60.4240% (minimum 75%, Missing); smooth muscle: 61.7329% (minimum 75%, Uncertain); spleen: 52.4540% (minimum 65%, Uncertain); stomach: 59.3750% (minimum 70%, Missing); thymus: 50.4425% (minimum 65%, Missing); thyroid gland: 47.7654% (minimum 65%, Uncertain); tongue: 57.5758% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.172346,-0.231507,-0.364865,0,2,partial,27.3,19.4,18.7,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 2); thyroid gland: 18.7 nTPM (manageable, limit 5); retina: 18.4 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); spleen: 15.5 nTPM (manageable, limit 5); parathyroid gland: 15.1 nTPM (protected, limit 2); liver: 14.7 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 2); esophagus: 12.5 nTPM (protected, limit 2); rectum: 12.1 nTPM (protected, limit 2); stomach: 11.7 nTPM (protected, limit 2); cerebellum: 11.6 nTPM (vital, limit 1); pancreas: 11.6 nTPM (vital, limit 1); kidney: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); urinary bladder: 11.4 nTPM (protected, limit 2); skin: 11.3 nTPM (manageable, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 2); lung: 10.8 nTPM (vital, limit 1); skeletal muscle: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10 nTPM (manageable, limit 5); duodenum: 10 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065883,CDK13,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.0996% (minimum 65%, Uncertain); adrenal gland: 65.5172% (minimum 75%, Uncertain); basal ganglia: 74.6725% (minimum 75%, Missing); bone marrow: 38.5135% (minimum 75%, Uncertain); cerebellum: 59.5819% (minimum 75%, Uncertain); cerebral cortex: 63.5688% (minimum 75%, Uncertain); choroid plexus: 68.4000% (minimum 75%, Missing); colon: 60.6383% (minimum 70%, Uncertain); duodenum: 63.0996% (minimum 75%, Missing); esophagus: 57.7703% (minimum 70%, Missing); heart muscle: 65.2672% (minimum 75%, Missing); kidney: 59.5819% (minimum 75%, Missing); liver: 53.7736% (minimum 75%, Uncertain); lung: 61.2903% (minimum 75%, Uncertain); lymph node: 46.8493% (minimum 70%, Uncertain); pancreas: 59.5819% (minimum 75%, Uncertain); parathyroid gland: 53.1056% (minimum 70%, Missing); pituitary gland: 68.9516% (minimum 75%, Missing); rectum: 58.5616% (minimum 70%, Missing); retina: 48.1690% (minimum 75%, Missing); salivary gland: 59.7902% (minimum 70%, Uncertain); skeletal muscle: 61.2903% (minimum 75%, Uncertain); skin: 60.2113% (minimum 65%, Missing); small intestine: 60.4240% (minimum 75%, Missing); smooth muscle: 61.7329% (minimum 75%, Uncertain); spleen: 52.4540% (minimum 65%, Uncertain); stomach: 59.3750% (minimum 70%, Missing); thymus: 50.4425% (minimum 65%, Missing); thyroid gland: 47.7654% (minimum 65%, Uncertain); tongue: 57.5758% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.172346,-0.231507,-0.364865,0,2,partial,27.3,19.4,18.7,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 3); thyroid gland: 18.7 nTPM (manageable, limit 5); retina: 18.4 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); spleen: 15.5 nTPM (manageable, limit 5); parathyroid gland: 15.1 nTPM (protected, limit 3); liver: 14.7 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 3); esophagus: 12.5 nTPM (protected, limit 3); rectum: 12.1 nTPM (protected, limit 3); stomach: 11.7 nTPM (protected, limit 3); cerebellum: 11.6 nTPM (vital, limit 1); pancreas: 11.6 nTPM (vital, limit 1); kidney: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); urinary bladder: 11.4 nTPM (protected, limit 3); skin: 11.3 nTPM (manageable, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 3); lung: 10.8 nTPM (vital, limit 1); skeletal muscle: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10 nTPM (manageable, limit 5); duodenum: 10 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065883,CDK13,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.0996% (minimum 65%, Uncertain); adrenal gland: 65.5172% (minimum 75%, Uncertain); basal ganglia: 74.6725% (minimum 75%, Missing); bone marrow: 38.5135% (minimum 75%, Uncertain); cerebellum: 59.5819% (minimum 75%, Uncertain); cerebral cortex: 63.5688% (minimum 75%, Uncertain); choroid plexus: 68.4000% (minimum 75%, Missing); colon: 60.6383% (minimum 70%, Uncertain); duodenum: 63.0996% (minimum 75%, Missing); esophagus: 57.7703% (minimum 70%, Missing); heart muscle: 65.2672% (minimum 75%, Missing); kidney: 59.5819% (minimum 75%, Missing); liver: 53.7736% (minimum 75%, Uncertain); lung: 61.2903% (minimum 75%, Uncertain); lymph node: 46.8493% (minimum 70%, Uncertain); pancreas: 59.5819% (minimum 75%, Uncertain); parathyroid gland: 53.1056% (minimum 70%, Missing); pituitary gland: 68.9516% (minimum 75%, Missing); rectum: 58.5616% (minimum 70%, Missing); retina: 48.1690% (minimum 75%, Missing); salivary gland: 59.7902% (minimum 70%, Uncertain); skeletal muscle: 61.2903% (minimum 75%, Uncertain); skin: 60.2113% (minimum 65%, Missing); small intestine: 60.4240% (minimum 75%, Missing); smooth muscle: 61.7329% (minimum 75%, Uncertain); spleen: 52.4540% (minimum 65%, Uncertain); stomach: 59.3750% (minimum 70%, Missing); thymus: 50.4425% (minimum 65%, Missing); thyroid gland: 47.7654% (minimum 65%, Uncertain); tongue: 57.5758% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.172346,-0.231507,-0.364865,0,2,partial,27.3,19.4,18.7,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 3); thyroid gland: 18.7 nTPM (manageable, limit 5); retina: 18.4 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); spleen: 15.5 nTPM (manageable, limit 5); parathyroid gland: 15.1 nTPM (protected, limit 3); liver: 14.7 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 3); esophagus: 12.5 nTPM (protected, limit 3); rectum: 12.1 nTPM (protected, limit 3); stomach: 11.7 nTPM (protected, limit 3); cerebellum: 11.6 nTPM (vital, limit 1); pancreas: 11.6 nTPM (vital, limit 1); kidney: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); urinary bladder: 11.4 nTPM (protected, limit 3); skin: 11.3 nTPM (manageable, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 3); lung: 10.8 nTPM (vital, limit 1); skeletal muscle: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10 nTPM (manageable, limit 5); duodenum: 10 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065883,CDK13,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.0996% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 65.5172% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.6725% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 38.5135% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 59.5819% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.5688% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.4000% (minimum 75%, Baseline (adaptation disabled)); colon: 60.6383% (minimum 70%, Baseline (adaptation disabled)); duodenum: 63.0996% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.7703% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.2672% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.5819% (minimum 75%, Baseline (adaptation disabled)); liver: 53.7736% (minimum 75%, Baseline (adaptation disabled)); lung: 61.2903% (minimum 75%, Baseline (adaptation disabled)); lymph node: 46.8493% (minimum 70%, Baseline (adaptation disabled)); pancreas: 59.5819% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 53.1056% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 68.9516% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.5616% (minimum 70%, Baseline (adaptation disabled)); retina: 48.1690% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.7902% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 61.2903% (minimum 75%, Baseline (adaptation disabled)); skin: 60.2113% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.4240% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.7329% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.4540% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.3750% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.4425% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 47.7654% (minimum 65%, Baseline (adaptation disabled)); tongue: 57.5758% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 70%, Baseline (adaptation disabled))",-0.172346,-0.231507,-0.364865,0,2,partial,27.3,19.4,18.7,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 3); thyroid gland: 18.7 nTPM (manageable, limit 5); retina: 18.4 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); spleen: 15.5 nTPM (manageable, limit 5); parathyroid gland: 15.1 nTPM (protected, limit 3); liver: 14.7 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 3); esophagus: 12.5 nTPM (protected, limit 3); rectum: 12.1 nTPM (protected, limit 3); stomach: 11.7 nTPM (protected, limit 3); cerebellum: 11.6 nTPM (vital, limit 1); pancreas: 11.6 nTPM (vital, limit 1); kidney: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); urinary bladder: 11.4 nTPM (protected, limit 3); skin: 11.3 nTPM (manageable, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 3); lung: 10.8 nTPM (vital, limit 1); skeletal muscle: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10 nTPM (manageable, limit 5); duodenum: 10 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000065883,CDK13,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.4379% (minimum 95%, Enhanced); amygdala: 44.2867% (minimum 99%, Missing); basal ganglia: 52.0254% (minimum 99%, Missing); cerebellum: 84.2986% (minimum 95%, Enhanced); cerebral cortex: 41.6932% (minimum 99%, Missing); choroid plexus: 90.9722% (minimum 99%, Missing); hippocampal formation: 53.9539% (minimum 99%, Missing); hypothalamus: 63.1021% (minimum 99%, Missing); midbrain: 68.6583% (minimum 99%, Missing); pituitary gland: 90.4696% (minimum 99%, Missing); retina: 45.6446% (minimum 99%, Missing); spinal cord: 85.9580% (minimum 99%, Missing)",0.05,0.03,-0.573068,0,3,partial,91.6,1.9,0.1,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 6); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066032,CTNNA2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 44.2867% (minimum 75%, Missing); basal ganglia: 52.0254% (minimum 75%, Missing); cerebral cortex: 41.6932% (minimum 75%, Missing); hippocampal formation: 53.9539% (minimum 75%, Missing); hypothalamus: 63.1021% (minimum 75%, Missing); midbrain: 68.6583% (minimum 75%, Missing); retina: 45.6446% (minimum 75%, Missing)",0.35,0.3,-0.333068,0,3,partial,91.6,1.9,0.1,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 6); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066032,CTNNA2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 44.2867% (minimum 75%, Missing); basal ganglia: 52.0254% (minimum 75%, Missing); cerebral cortex: 41.6932% (minimum 75%, Missing); hippocampal formation: 53.9539% (minimum 75%, Missing); hypothalamus: 63.1021% (minimum 75%, Missing); midbrain: 68.6583% (minimum 75%, Missing); retina: 45.6446% (minimum 75%, Missing)",0.35,0.3,-0.333068,0,3,partial,91.6,1.9,0.1,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 6); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066032,CTNNA2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 44.2867% (minimum 75%, Missing); basal ganglia: 52.0254% (minimum 75%, Missing); cerebral cortex: 41.6932% (minimum 75%, Missing); hippocampal formation: 53.9539% (minimum 75%, Missing); hypothalamus: 63.1021% (minimum 75%, Missing); midbrain: 68.6583% (minimum 75%, Missing); retina: 45.6446% (minimum 75%, Missing)",0.35,0.3,-0.333068,0,3,partial,91.6,1.9,0.1,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 6); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066032,CTNNA2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 44.2867% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 52.0254% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 41.6932% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 53.9539% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.1021% (minimum 75%, Baseline (adaptation disabled)); midbrain: 68.6583% (minimum 75%, Baseline (adaptation disabled)); retina: 45.6446% (minimum 75%, Baseline (adaptation disabled))",0.348476,0.27181,-0.333068,0,3,partial,91.6,1.9,0.1,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066032,CTNNA2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.6910% (minimum 99%, Missing); amygdala: 90.2913% (minimum 99%, Missing); basal ganglia: 87.4608% (minimum 99%, Missing); cerebellum: 97.5524% (minimum 99%, Missing); cerebral cortex: 91.7763% (minimum 99%, Missing); choroid plexus: 73.8095% (minimum 99%, Missing); colon: 96.2069% (minimum 97%, Missing); duodenum: 96.5398% (minimum 99%, Missing); heart muscle: 92.6910% (minimum 99%, Missing); hippocampal formation: 90.8795% (minimum 99%, Missing); hypothalamus: 86.6460% (minimum 99%, Missing); kidney: 75.6098% (minimum 99%, Missing); liver: 80.6358% (minimum 99%, Missing); lung: 93.6242% (minimum 99%, Missing); midbrain: 89.1374% (minimum 99%, Missing); pancreas: 89.7106% (minimum 99%, Missing); parathyroid gland: 92.6910% (minimum 97%, Missing); pituitary gland: 89.4231% (minimum 99%, Missing); rectum: 96.2069% (minimum 97%, Missing); retina: 87.7358% (minimum 99%, Missing); salivary gland: 96.5398% (minimum 97%, Missing); skeletal muscle: 93.9394% (minimum 99%, Missing); small intestine: 98.5866% (minimum 99%, Missing); smooth muscle: 97.2125% (minimum 99%, Missing); spinal cord: 90.5844% (minimum 99%, Missing); stomach: 94.5763% (minimum 97%, Missing); thyroid gland: 85.3211% (minimum 95%, Missing); tongue: 92.0792% (minimum 97%, Missing); urinary bladder: 96.8750% (minimum 97%, Missing)",-0.096789,-0.0492079,-0.251905,0,80,unavailable,9.9,2.4,4.8,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066185,ZMYND12,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 73.8095% (minimum 75%, Missing)",0.203211,0.220792,-0.0119048,0,80,unavailable,9.9,2.4,4.8,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066185,ZMYND12,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 73.8095% (minimum 75%, Missing)",0.203211,0.220792,-0.0119048,0,80,unavailable,9.9,2.4,4.8,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066185,ZMYND12,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 73.8095% (minimum 75%, Missing)",0.203211,0.220792,-0.0119048,0,80,unavailable,9.9,2.4,4.8,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066185,ZMYND12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 73.8095% (minimum 75%, Baseline (adaptation disabled))",0.203211,0.220792,-0.0119048,0,80,unavailable,9.9,2.4,4.8,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066185,ZMYND12,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.9394% (minimum 95%, Missing); bone marrow: 23.6641% (minimum 99%, Missing); cerebral cortex: 96.8750% (minimum 99%, Missing); colon: 65.9574% (minimum 97%, Missing); duodenum: 60.7843% (minimum 99%, Missing); esophagus: 67.3913% (minimum 97%, Missing); liver: 83.7838% (minimum 99%, Missing); lung: 91.1765% (minimum 99%, Missing); lymph node: 37.8049% (minimum 97%, Missing); rectum: 63.2653% (minimum 97%, Missing); salivary gland: 93.9394% (minimum 97%, Missing); skin: 54.3860% (minimum 95%, Missing); small intestine: 63.2653% (minimum 99%, Missing); smooth muscle: 83.7838% (minimum 99%, Missing); spinal cord: 93.9394% (minimum 99%, Missing); spleen: 77.5000% (minimum 95%, Missing); stomach: 73.8095% (minimum 97%, Missing); thymus: 15.8163% (minimum 95%, Missing); urinary bladder: 83.7838% (minimum 97%, Missing)",-0.791837,-0.591951,-0.753359,0,80,unavailable,10,5.1,16.5,"thymus: 16.5 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066279,ASPM,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 23.6641% (minimum 75%, Missing); colon: 65.9574% (minimum 70%, Missing); duodenum: 60.7843% (minimum 75%, Missing); esophagus: 67.3913% (minimum 70%, Missing); lymph node: 37.8049% (minimum 70%, Missing); rectum: 63.2653% (minimum 70%, Missing); skin: 54.3860% (minimum 65%, Missing); small intestine: 63.2653% (minimum 75%, Missing); thymus: 15.8163% (minimum 65%, Missing)",-0.491837,-0.321951,-0.513359,0,80,unavailable,10,5.1,16.5,"thymus: 16.5 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066279,ASPM,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 23.6641% (minimum 75%, Missing); colon: 65.9574% (minimum 70%, Missing); duodenum: 60.7843% (minimum 75%, Missing); esophagus: 67.3913% (minimum 70%, Missing); lymph node: 37.8049% (minimum 70%, Missing); rectum: 63.2653% (minimum 70%, Missing); skin: 54.3860% (minimum 65%, Missing); small intestine: 63.2653% (minimum 75%, Missing); thymus: 15.8163% (minimum 65%, Missing)",-0.491837,-0.321951,-0.513359,0,80,unavailable,10,5.1,16.5,"thymus: 16.5 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066279,ASPM,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 23.6641% (minimum 75%, Missing); colon: 65.9574% (minimum 70%, Missing); duodenum: 60.7843% (minimum 75%, Missing); esophagus: 67.3913% (minimum 70%, Missing); lymph node: 37.8049% (minimum 70%, Missing); rectum: 63.2653% (minimum 70%, Missing); skin: 54.3860% (minimum 65%, Missing); small intestine: 63.2653% (minimum 75%, Missing); thymus: 15.8163% (minimum 65%, Missing)",-0.491837,-0.321951,-0.513359,0,80,unavailable,10,5.1,16.5,"thymus: 16.5 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066279,ASPM,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 23.6641% (minimum 75%, Baseline (adaptation disabled)); colon: 65.9574% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.7843% (minimum 75%, Baseline (adaptation disabled)); esophagus: 67.3913% (minimum 70%, Baseline (adaptation disabled)); lymph node: 37.8049% (minimum 70%, Baseline (adaptation disabled)); rectum: 63.2653% (minimum 70%, Baseline (adaptation disabled)); skin: 54.3860% (minimum 65%, Baseline (adaptation disabled)); small intestine: 63.2653% (minimum 75%, Baseline (adaptation disabled)); thymus: 15.8163% (minimum 65%, Baseline (adaptation disabled))",-0.491837,-0.321951,-0.513359,0,80,unavailable,10,5.1,16.5,"thymus: 16.5 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066279,ASPM,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"heart muscle: 98.2890% (minimum 99%, Missing)",0.0404215,0.0280695,-0.00711027,0,3,partial,1.1,0.4,0.5,,heart muscle / cardiomyocytes: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066923,STAG3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.340421,0.298069,0.23289,0,3,partial,1.1,0.4,0.5,,heart muscle / cardiomyocytes: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066923,STAG3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.340421,0.298069,0.23289,0,3,partial,1.1,0.4,0.5,,heart muscle / cardiomyocytes: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066923,STAG3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.340421,0.298069,0.23289,0,3,partial,1.1,0.4,0.5,,heart muscle / cardiomyocytes: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066923,STAG3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.340421,0.292322,0.229167,0,3,partial,1.1,0.4,0.5,"bone marrow: 1.1 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000066923,STAG3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.9167% (minimum 95%, Uncertain); adrenal gland: 81.3953% (minimum 99%, Uncertain); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 82.3529% (minimum 99%, Missing); bone marrow: 46.9799% (minimum 99%, Missing); cerebellum: 70.7071% (minimum 99%, Missing); cerebral cortex: 78.6517% (minimum 99%, Missing); choroid plexus: 92.1053% (minimum 99%, Missing); colon: 76.0870% (minimum 97%, Missing); duodenum: 72.9167% (minimum 99%, Missing); esophagus: 61.4035% (minimum 97%, Uncertain); heart muscle: 79.5455% (minimum 99%, Uncertain); hippocampal formation: 82.3529% (minimum 99%, Missing); hypothalamus: 83.3333% (minimum 99%, Missing); kidney: 80.4598% (minimum 99%, Missing); liver: 61.9469% (minimum 99%, Missing); lung: 80.4598% (minimum 99%, Missing); lymph node: 85.3659% (minimum 97%, Missing); midbrain: 83.3333% (minimum 99%, Missing); pancreas: 73.6842% (minimum 99%, Missing); parathyroid gland: 78.6517% (minimum 97%, Missing); pituitary gland: 82.3529% (minimum 99%, Missing); rectum: 58.8235% (minimum 97%, Missing); retina: 76.0870% (minimum 99%, Missing); salivary gland: 72.9167% (minimum 97%, Missing); skeletal muscle: 67.9612% (minimum 99%, Missing); skin: 80.4598% (minimum 95%, Missing); small intestine: 63.0631% (minimum 99%, Missing); spinal cord: 81.3953% (minimum 99%, Missing); spleen: 76.9231% (minimum 95%, Missing); stomach: 74.4681% (minimum 97%, Missing); thyroid gland: 72.1649% (minimum 95%, Missing); tongue: 49.6454% (minimum 97%, Missing); urinary bladder: 69.3069% (minimum 97%, Missing)",-0.228351,-0.473546,-0.520201,0,4,partial,7.9,7.1,2.7,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 2); rectum: 4.9 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000067646,ZFY,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.9799% (minimum 75%, Missing); cerebellum: 70.7071% (minimum 75%, Missing); duodenum: 72.9167% (minimum 75%, Missing); esophagus: 61.4035% (minimum 70%, Uncertain); liver: 61.9469% (minimum 75%, Missing); pancreas: 73.6842% (minimum 75%, Missing); rectum: 58.8235% (minimum 70%, Missing); skeletal muscle: 67.9612% (minimum 75%, Missing); small intestine: 63.0631% (minimum 75%, Missing); tongue: 49.6454% (minimum 70%, Missing); urinary bladder: 69.3069% (minimum 70%, Missing)",0.0716495,-0.203546,-0.280201,0,4,partial,7.9,7.1,2.7,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 2); rectum: 4.9 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000067646,ZFY,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.9799% (minimum 75%, Missing); cerebellum: 70.7071% (minimum 75%, Missing); duodenum: 72.9167% (minimum 75%, Missing); esophagus: 61.4035% (minimum 70%, Uncertain); liver: 61.9469% (minimum 75%, Missing); pancreas: 73.6842% (minimum 75%, Missing); rectum: 58.8235% (minimum 70%, Missing); skeletal muscle: 67.9612% (minimum 75%, Missing); small intestine: 63.0631% (minimum 75%, Missing); tongue: 49.6454% (minimum 70%, Missing); urinary bladder: 69.3069% (minimum 70%, Missing)",0.0716495,-0.203546,-0.280201,0,4,partial,7.9,7.1,2.7,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 3); rectum: 4.9 nTPM (protected, limit 3); esophagus: 4.4 nTPM (protected, limit 3); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000067646,ZFY,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.9799% (minimum 75%, Missing); cerebellum: 70.7071% (minimum 75%, Missing); duodenum: 72.9167% (minimum 75%, Missing); esophagus: 61.4035% (minimum 70%, Uncertain); liver: 61.9469% (minimum 75%, Missing); pancreas: 73.6842% (minimum 75%, Missing); rectum: 58.8235% (minimum 70%, Missing); skeletal muscle: 67.9612% (minimum 75%, Missing); small intestine: 63.0631% (minimum 75%, Missing); tongue: 49.6454% (minimum 70%, Missing); urinary bladder: 69.3069% (minimum 70%, Missing)",0.0716495,-0.203546,-0.280201,0,4,partial,7.9,7.1,2.7,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 3); rectum: 4.9 nTPM (protected, limit 3); esophagus: 4.4 nTPM (protected, limit 3); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000067646,ZFY,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.9799% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.7071% (minimum 75%, Baseline (adaptation disabled)); duodenum: 72.9167% (minimum 75%, Baseline (adaptation disabled)); esophagus: 61.4035% (minimum 70%, Baseline (adaptation disabled)); liver: 61.9469% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.6842% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.8235% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 67.9612% (minimum 75%, Baseline (adaptation disabled)); small intestine: 63.0631% (minimum 75%, Baseline (adaptation disabled)); tongue: 49.6454% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 69.3069% (minimum 70%, Baseline (adaptation disabled))",0.0716495,-0.203546,-0.280201,0,4,partial,7.9,7.1,2.7,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 3); rectum: 4.9 nTPM (protected, limit 3); esophagus: 4.4 nTPM (protected, limit 3); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000067646,ZFY,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.9259% (minimum 95%, Missing); adrenal gland: 87.2340% (minimum 99%, Missing); amygdala: 93.1818% (minimum 99%, Missing); basal ganglia: 93.1818% (minimum 99%, Missing); bone marrow: 18.7215% (minimum 99%, Missing); cerebellum: 97.6190% (minimum 99%, Missing); cerebral cortex: 69.4915% (minimum 99%, Missing); choroid plexus: 89.1304% (minimum 99%, Missing); colon: 47.6744% (minimum 97%, Missing); duodenum: 39.4231% (minimum 99%, Missing); esophagus: 53.2468% (minimum 97%, Missing); heart muscle: 80.3922% (minimum 99%, Missing); hippocampal formation: 91.1111% (minimum 99%, Missing); hypothalamus: 93.1818% (minimum 99%, Missing); kidney: 87.2340% (minimum 99%, Missing); liver: 75.9259% (minimum 99%, Missing); lung: 65.0794% (minimum 99%, Missing); lymph node: 29.0780% (minimum 97%, Missing); midbrain: 91.1111% (minimum 99%, Missing); pancreas: 89.1304% (minimum 99%, Missing); parathyroid gland: 93.1818% (minimum 97%, Missing); rectum: 43.6170% (minimum 97%, Missing); retina: 71.9298% (minimum 99%, Missing); salivary gland: 89.1304% (minimum 97%, Missing); skeletal muscle: 78.8462% (minimum 99%, Missing); skin: 57.7465% (minimum 95%, Missing); small intestine: 46.0674% (minimum 99%, Missing); smooth muscle: 53.9474% (minimum 99%, Missing); spinal cord: 83.6735% (minimum 99%, Missing); spleen: 56.9444% (minimum 95%, Missing); stomach: 65.0794% (minimum 97%, Missing); thymus: 17.0124% (minimum 95%, Missing); thyroid gland: 77.3585% (minimum 95%, Missing); tongue: 91.1111% (minimum 97%, Missing); urinary bladder: 67.2131% (minimum 97%, Missing)",-0.779876,-0.67922,-0.802785,0,80,unavailable,17.8,10,20,"thymus: 20 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); small intestine: 4.8 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068489,PRR11,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 18.7215% (minimum 75%, Missing); cerebral cortex: 69.4915% (minimum 75%, Missing); colon: 47.6744% (minimum 70%, Missing); duodenum: 39.4231% (minimum 75%, Missing); esophagus: 53.2468% (minimum 70%, Missing); lung: 65.0794% (minimum 75%, Missing); lymph node: 29.0780% (minimum 70%, Missing); rectum: 43.6170% (minimum 70%, Missing); retina: 71.9298% (minimum 75%, Missing); skin: 57.7465% (minimum 65%, Missing); small intestine: 46.0674% (minimum 75%, Missing); smooth muscle: 53.9474% (minimum 75%, Missing); spleen: 56.9444% (minimum 65%, Missing); stomach: 65.0794% (minimum 70%, Missing); thymus: 17.0124% (minimum 65%, Missing); urinary bladder: 67.2131% (minimum 70%, Missing)",-0.479876,-0.40922,-0.562785,0,80,unavailable,17.8,10,20,"thymus: 20 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); small intestine: 4.8 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068489,PRR11,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 18.7215% (minimum 75%, Missing); cerebral cortex: 69.4915% (minimum 75%, Missing); colon: 47.6744% (minimum 70%, Missing); duodenum: 39.4231% (minimum 75%, Missing); esophagus: 53.2468% (minimum 70%, Missing); lung: 65.0794% (minimum 75%, Missing); lymph node: 29.0780% (minimum 70%, Missing); rectum: 43.6170% (minimum 70%, Missing); retina: 71.9298% (minimum 75%, Missing); skin: 57.7465% (minimum 65%, Missing); small intestine: 46.0674% (minimum 75%, Missing); smooth muscle: 53.9474% (minimum 75%, Missing); spleen: 56.9444% (minimum 65%, Missing); stomach: 65.0794% (minimum 70%, Missing); thymus: 17.0124% (minimum 65%, Missing); urinary bladder: 67.2131% (minimum 70%, Missing)",-0.479876,-0.40922,-0.562785,0,80,unavailable,17.8,10,20,"thymus: 20 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); small intestine: 4.8 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068489,PRR11,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 18.7215% (minimum 75%, Missing); cerebral cortex: 69.4915% (minimum 75%, Missing); colon: 47.6744% (minimum 70%, Missing); duodenum: 39.4231% (minimum 75%, Missing); esophagus: 53.2468% (minimum 70%, Missing); lung: 65.0794% (minimum 75%, Missing); lymph node: 29.0780% (minimum 70%, Missing); rectum: 43.6170% (minimum 70%, Missing); retina: 71.9298% (minimum 75%, Missing); skin: 57.7465% (minimum 65%, Missing); small intestine: 46.0674% (minimum 75%, Missing); smooth muscle: 53.9474% (minimum 75%, Missing); spleen: 56.9444% (minimum 65%, Missing); stomach: 65.0794% (minimum 70%, Missing); thymus: 17.0124% (minimum 65%, Missing); urinary bladder: 67.2131% (minimum 70%, Missing)",-0.479876,-0.40922,-0.562785,0,80,unavailable,17.8,10,20,"thymus: 20 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); small intestine: 4.8 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068489,PRR11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 18.7215% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 69.4915% (minimum 75%, Baseline (adaptation disabled)); colon: 47.6744% (minimum 70%, Baseline (adaptation disabled)); duodenum: 39.4231% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.2468% (minimum 70%, Baseline (adaptation disabled)); lung: 65.0794% (minimum 75%, Baseline (adaptation disabled)); lymph node: 29.0780% (minimum 70%, Baseline (adaptation disabled)); rectum: 43.6170% (minimum 70%, Baseline (adaptation disabled)); retina: 71.9298% (minimum 75%, Baseline (adaptation disabled)); skin: 57.7465% (minimum 65%, Baseline (adaptation disabled)); small intestine: 46.0674% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.9474% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.9444% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.0794% (minimum 70%, Baseline (adaptation disabled)); thymus: 17.0124% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 67.2131% (minimum 70%, Baseline (adaptation disabled))",-0.479876,-0.40922,-0.562785,0,80,unavailable,17.8,10,20,"thymus: 20 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); small intestine: 4.8 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068489,PRR11,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.5743% (minimum 95%, Missing); adrenal gland: 86.4130% (minimum 99%, Missing); amygdala: 75.7143% (minimum 99%, Missing); basal ganglia: 79.6327% (minimum 99%, Missing); bone marrow: 79.1045% (minimum 99%, Missing); cerebellum: 85.3309% (minimum 99%, Missing); cerebral cortex: 56.9212% (minimum 99%, Missing); choroid plexus: 87.3626% (minimum 99%, Missing); colon: 78.1967% (minimum 97%, Missing); duodenum: 81.1224% (minimum 99%, Missing); esophagus: 79.7659% (minimum 97%, Missing); heart muscle: 88.8268% (minimum 98%, Approved); hippocampal formation: 75.2366% (minimum 99%, Missing); hypothalamus: 76.4423% (minimum 99%, Missing); kidney: 85.9459% (minimum 98%, Approved); liver: 90.1701% (minimum 98%, Approved); lung: 83.3916% (minimum 99%, Missing); lymph node: 59.7744% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 82.8125% (minimum 99%, Missing); parathyroid gland: 80.0336% (minimum 97%, Missing); pituitary gland: 85.1786% (minimum 99%, Missing); rectum: 77.0598% (minimum 97%, Missing); retina: 53.5354% (minimum 99%, Missing); salivary gland: 87.6838% (minimum 95%, Approved); skeletal muscle: 91.2046% (minimum 98%, Approved); skin: 89.3258% (minimum 95%, Missing); small intestine: 75.4747% (minimum 99%, Missing); smooth muscle: 79.1045% (minimum 98%, Approved); spinal cord: 73.3846% (minimum 99%, Missing); spleen: 72.6027% (minimum 95%, Missing); stomach: 83.6842% (minimum 97%, Missing); thymus: 52.9412% (minimum 95%, Missing); thyroid gland: 79.6327% (minimum 90%, Approved); tongue: 88.0074% (minimum 97%, Missing); urinary bladder: 70.9821% (minimum 97%, Missing)",-0.420588,-0.372256,-0.454646,0,4,partial,41.4,32.1,42.4,"thymus: 42.4 nTPM (manageable, limit 5); retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 2); urinary bladder: 19.5 nTPM (protected, limit 2); spleen: 18 nTPM (manageable, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 2); colon: 13.3 nTPM (protected, limit 2); smooth muscle: 12.6 nTPM (vital, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); thyroid gland: 12.2 nTPM (manageable, limit 10); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 2); parathyroid gland: 11.9 nTPM (protected, limit 2); adipose tissue: 11.5 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 2); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 2); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 4); tongue: 6.5 nTPM (protected, limit 2); heart muscle: 6 nTPM (vital, limit 2); skin: 5.7 nTPM (manageable, limit 5); liver: 5.2 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068796,KIF2A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 56.9212% (minimum 75%, Missing); lymph node: 59.7744% (minimum 70%, Missing); retina: 53.5354% (minimum 75%, Missing); spinal cord: 73.3846% (minimum 75%, Missing); thymus: 52.9412% (minimum 65%, Missing)",-0.120588,-0.102256,-0.214646,0,4,partial,41.4,32.1,42.4,"thymus: 42.4 nTPM (manageable, limit 5); retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 2); urinary bladder: 19.5 nTPM (protected, limit 2); spleen: 18 nTPM (manageable, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 2); colon: 13.3 nTPM (protected, limit 2); smooth muscle: 12.6 nTPM (vital, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); thyroid gland: 12.2 nTPM (manageable, limit 10); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 2); parathyroid gland: 11.9 nTPM (protected, limit 2); adipose tissue: 11.5 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 2); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 2); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 4); tongue: 6.5 nTPM (protected, limit 2); heart muscle: 6 nTPM (vital, limit 2); skin: 5.7 nTPM (manageable, limit 5); liver: 5.2 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068796,KIF2A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 56.9212% (minimum 75%, Missing); lymph node: 59.7744% (minimum 70%, Missing); retina: 53.5354% (minimum 75%, Missing); spinal cord: 73.3846% (minimum 75%, Missing); thymus: 52.9412% (minimum 65%, Missing)",-0.120588,-0.102256,-0.214646,0,4,partial,41.4,32.1,42.4,"thymus: 42.4 nTPM (manageable, limit 5); retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 3); urinary bladder: 19.5 nTPM (protected, limit 3); spleen: 18 nTPM (manageable, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 3); colon: 13.3 nTPM (protected, limit 3); smooth muscle: 12.6 nTPM (vital, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); thyroid gland: 12.2 nTPM (manageable, limit 10); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 3); parathyroid gland: 11.9 nTPM (protected, limit 3); adipose tissue: 11.5 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 3); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 2); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 4); tongue: 6.5 nTPM (protected, limit 3); heart muscle: 6 nTPM (vital, limit 2); skin: 5.7 nTPM (manageable, limit 5); liver: 5.2 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068796,KIF2A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 56.9212% (minimum 75%, Missing); lymph node: 59.7744% (minimum 70%, Missing); retina: 53.5354% (minimum 75%, Missing); spinal cord: 73.3846% (minimum 75%, Missing); thymus: 52.9412% (minimum 65%, Missing)",-0.120588,-0.102256,-0.214646,0,4,partial,41.4,32.1,42.4,"thymus: 42.4 nTPM (manageable, limit 5); retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 3); urinary bladder: 19.5 nTPM (protected, limit 3); spleen: 18 nTPM (manageable, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 3); colon: 13.3 nTPM (protected, limit 3); smooth muscle: 12.6 nTPM (vital, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); thyroid gland: 12.2 nTPM (manageable, limit 10); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 3); parathyroid gland: 11.9 nTPM (protected, limit 3); adipose tissue: 11.5 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 3); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 2); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 4); tongue: 6.5 nTPM (protected, limit 3); heart muscle: 6 nTPM (vital, limit 2); skin: 5.7 nTPM (manageable, limit 5); liver: 5.2 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068796,KIF2A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 56.9212% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.7744% (minimum 70%, Baseline (adaptation disabled)); retina: 53.5354% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.3846% (minimum 75%, Baseline (adaptation disabled)); thymus: 52.9412% (minimum 65%, Baseline (adaptation disabled))",-0.120588,-0.102256,-0.214646,0,4,partial,41.4,32.1,42.4,"thymus: 42.4 nTPM (manageable, limit 5); retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 3); urinary bladder: 19.5 nTPM (protected, limit 3); spleen: 18 nTPM (manageable, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 3); colon: 13.3 nTPM (protected, limit 3); smooth muscle: 12.6 nTPM (vital, limit 1); bone marrow: 12.6 nTPM (vital, limit 1); thyroid gland: 12.2 nTPM (manageable, limit 5); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 3); parathyroid gland: 11.9 nTPM (protected, limit 3); adipose tissue: 11.5 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 3); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); tongue: 6.5 nTPM (protected, limit 3); heart muscle: 6 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); liver: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068796,KIF2A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068985,PAGE1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068985,PAGE1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068985,PAGE1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068985,PAGE1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000068985,PAGE1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.9495% (minimum 99%, Missing); amygdala: 87.0370% (minimum 99%, Missing); basal ganglia: 93.0693% (minimum 99%, Missing); bone marrow: 94.0000% (minimum 99%, Missing); cerebellum: 97.9167% (minimum 99%, Missing); cerebral cortex: 83.9286% (minimum 99%, Missing); choroid plexus: 97.9167% (minimum 99%, Missing); colon: 94.0000% (minimum 97%, Missing); duodenum: 98.9474% (minimum 99%, Missing); esophagus: 94.0000% (minimum 97%, Missing); heart muscle: 91.2621% (minimum 99%, Missing); hippocampal formation: 88.6792% (minimum 99%, Missing); hypothalamus: 82.4561% (minimum 99%, Missing); kidney: 96.9072% (minimum 99%, Missing); liver: 98.9474% (minimum 99%, Missing); lung: 89.5238% (minimum 99%, Missing); lymph node: 89.5238% (minimum 97%, Missing); midbrain: 90.3846% (minimum 99%, Missing); pancreas: 98.9474% (minimum 99%, Missing); parathyroid gland: 91.2621% (minimum 97%, Missing); pituitary gland: 87.8505% (minimum 99%, Missing); rectum: 96.9072% (minimum 97%, Missing); retina: 91.2621% (minimum 99%, Missing); salivary gland: 94.0000% (minimum 97%, Missing); skeletal muscle: 97.9167% (minimum 99%, Missing); skin: 94.9495% (minimum 95%, Missing); small intestine: 92.1569% (minimum 99%, Missing); smooth muscle: 97.9167% (minimum 99%, Missing); spinal cord: 81.0345% (minimum 99%, Missing); spleen: 78.3333% (minimum 95%, Missing); stomach: 94.9495% (minimum 97%, Missing); thymus: 93.0693% (minimum 95%, Missing); thyroid gland: 87.8505% (minimum 95%, Missing); tongue: 96.9072% (minimum 97%, Missing); urinary bladder: 95.9184% (minimum 97%, Missing)",-0.166667,-0.0747619,-0.179655,0,80,unavailable,2.2,1.1,2.6,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069188,SDK2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.133333,0.195238,0.0603448,0,80,unavailable,2.2,1.1,2.6,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069188,SDK2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.133333,0.195238,0.0603448,0,80,unavailable,2.2,1.1,2.6,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069188,SDK2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.133333,0.195238,0.0603448,0,80,unavailable,2.2,1.1,2.6,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069188,SDK2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.133333,0.195238,0.0603448,0,80,unavailable,2.2,1.1,2.6,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069188,SDK2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,0,routine_complete,0.6,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069206,ADAM7,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0.6,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069206,ADAM7,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0.6,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069206,ADAM7,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0.6,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069206,ADAM7,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249835,0,0,routine_complete,0.6,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069206,ADAM7,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.4033% (minimum 95%, Uncertain); adrenal gland: 87.1429% (minimum 99%, Missing); amygdala: 87.1429% (minimum 99%, Missing); basal ganglia: 87.7698% (minimum 99%, Missing); bone marrow: 42.5087% (minimum 99%, Missing); cerebellum: 94.5736% (minimum 99%, Missing); cerebral cortex: 89.7059% (minimum 99%, Missing); choroid plexus: 73.9394% (minimum 99%, Missing); colon: 72.6190% (minimum 97%, Missing); duodenum: 76.2500% (minimum 99%, Missing); esophagus: 79.7386% (minimum 97%, Missing); heart muscle: 70.5202% (minimum 99%, Missing); hippocampal formation: 85.9155% (minimum 99%, Missing); hypothalamus: 85.9155% (minimum 99%, Missing); kidney: 76.2500% (minimum 99%, Missing); liver: 79.2208% (minimum 99%, Missing); lung: 59.5122% (minimum 99%, Missing); lymph node: 18.7982% (minimum 97%, Missing); midbrain: 82.9932% (minimum 99%, Missing); pancreas: 84.1379% (minimum 99%, Missing); parathyroid gland: 93.8462% (minimum 97%, Missing); pituitary gland: 84.7222% (minimum 99%, Missing); rectum: 75.7764% (minimum 97%, Missing); retina: 77.7070% (minimum 99%, Missing); salivary gland: 65.5914% (minimum 97%, Missing); skeletal muscle: 79.7386% (minimum 99%, Missing); skin: 76.7296% (minimum 95%, Missing); small intestine: 38.1250% (minimum 99%, Missing); smooth muscle: 85.3147% (minimum 99%, Missing); spinal cord: 78.7097% (minimum 99%, Missing); spleen: 31.9372% (minimum 95%, Missing); stomach: 69.3182% (minimum 97%, Missing); thymus: 28.3063% (minimum 95%, Missing); thyroid gland: 73.9394% (minimum 95%, Missing); tongue: 90.3704% (minimum 97%, Missing); urinary bladder: 68.5393% (minimum 97%, Missing)",-0.666937,-0.782018,-0.60875,0,2,partial,19.8,52.7,30.9,"lymph node: 52.7 nTPM (protected, limit 2); thymus: 30.9 nTPM (manageable, limit 5); spleen: 26 nTPM (manageable, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069493,CLEC2D,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 42.5087% (minimum 75%, Missing); choroid plexus: 73.9394% (minimum 75%, Missing); heart muscle: 70.5202% (minimum 75%, Missing); lung: 59.5122% (minimum 75%, Missing); lymph node: 18.7982% (minimum 70%, Missing); salivary gland: 65.5914% (minimum 70%, Missing); small intestine: 38.1250% (minimum 75%, Missing); spleen: 31.9372% (minimum 65%, Missing); stomach: 69.3182% (minimum 70%, Missing); thymus: 28.3063% (minimum 65%, Missing); urinary bladder: 68.5393% (minimum 70%, Missing)",-0.366937,-0.512018,-0.36875,0,2,partial,19.8,52.7,30.9,"lymph node: 52.7 nTPM (protected, limit 2); thymus: 30.9 nTPM (manageable, limit 5); spleen: 26 nTPM (manageable, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069493,CLEC2D,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 42.5087% (minimum 75%, Missing); choroid plexus: 73.9394% (minimum 75%, Missing); heart muscle: 70.5202% (minimum 75%, Missing); lung: 59.5122% (minimum 75%, Missing); lymph node: 18.7982% (minimum 70%, Missing); salivary gland: 65.5914% (minimum 70%, Missing); small intestine: 38.1250% (minimum 75%, Missing); spleen: 31.9372% (minimum 65%, Missing); stomach: 69.3182% (minimum 70%, Missing); thymus: 28.3063% (minimum 65%, Missing); urinary bladder: 68.5393% (minimum 70%, Missing)",-0.366937,-0.512018,-0.36875,0,2,partial,19.8,52.7,30.9,"lymph node: 52.7 nTPM (protected, limit 3); thymus: 30.9 nTPM (manageable, limit 5); spleen: 26 nTPM (manageable, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); heart muscle: 5.1 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 3); choroid plexus: 4.3 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069493,CLEC2D,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 42.5087% (minimum 75%, Missing); choroid plexus: 73.9394% (minimum 75%, Missing); heart muscle: 70.5202% (minimum 75%, Missing); lung: 59.5122% (minimum 75%, Missing); lymph node: 18.7982% (minimum 70%, Missing); salivary gland: 65.5914% (minimum 70%, Missing); small intestine: 38.1250% (minimum 75%, Missing); spleen: 31.9372% (minimum 65%, Missing); stomach: 69.3182% (minimum 70%, Missing); thymus: 28.3063% (minimum 65%, Missing); urinary bladder: 68.5393% (minimum 70%, Missing)",-0.366937,-0.512018,-0.36875,0,2,partial,19.8,52.7,30.9,"lymph node: 52.7 nTPM (protected, limit 3); thymus: 30.9 nTPM (manageable, limit 5); spleen: 26 nTPM (manageable, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); heart muscle: 5.1 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 3); choroid plexus: 4.3 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069493,CLEC2D,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 42.5087% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.9394% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.5202% (minimum 75%, Baseline (adaptation disabled)); lung: 59.5122% (minimum 75%, Baseline (adaptation disabled)); lymph node: 18.7982% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 65.5914% (minimum 70%, Baseline (adaptation disabled)); small intestine: 38.1250% (minimum 75%, Baseline (adaptation disabled)); spleen: 31.9372% (minimum 65%, Baseline (adaptation disabled)); stomach: 69.3182% (minimum 70%, Baseline (adaptation disabled)); thymus: 28.3063% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 68.5393% (minimum 70%, Baseline (adaptation disabled))",-0.366937,-0.512018,-0.36875,0,2,partial,19.8,52.7,30.9,"lymph node: 52.7 nTPM (protected, limit 3); thymus: 30.9 nTPM (manageable, limit 5); spleen: 26 nTPM (manageable, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); heart muscle: 5.1 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 3); choroid plexus: 4.3 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000069493,CLEC2D,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.7917% (minimum 99%, Missing); amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 82.7273% (minimum 99%, Missing); bone marrow: 80.5310% (minimum 99%, Missing); cerebellum: 91.9192% (minimum 99%, Missing); cerebral cortex: 83.4862% (minimum 99%, Missing); choroid plexus: 91.0000% (minimum 99%, Missing); colon: 94.7917% (minimum 97%, Missing); duodenum: 92.8571% (minimum 99%, Missing); esophagus: 85.8491% (minimum 97%, Missing); heart muscle: 92.8571% (minimum 99%, Missing); hippocampal formation: 88.3495% (minimum 99%, Missing); hypothalamus: 89.2157% (minimum 99%, Missing); kidney: 94.7917% (minimum 99%, Missing); liver: 94.7917% (minimum 99%, Missing); lung: 93.8144% (minimum 99%, Missing); lymph node: 87.5000% (minimum 97%, Missing); midbrain: 83.4862% (minimum 99%, Missing); pancreas: 91.9192% (minimum 99%, Missing); parathyroid gland: 92.8571% (minimum 97%, Missing); pituitary gland: 92.8571% (minimum 99%, Missing); rectum: 94.7917% (minimum 97%, Missing); retina: 11.9895% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 69.4656% (minimum 99%, Missing); skin: 59.8684% (minimum 95%, Missing); small intestine: 89.2157% (minimum 99%, Missing); smooth muscle: 95.7895% (minimum 99%, Missing); spinal cord: 92.8571% (minimum 99%, Missing); stomach: 94.7917% (minimum 97%, Missing); thyroid gland: 90.0990% (minimum 95%, Missing); tongue: 89.2157% (minimum 97%, Missing); urinary bladder: 94.7917% (minimum 97%, Uncertain)",-0.351316,-0.27,-0.870105,0,2,partial,66.8,3.9,6.1,"retina: 66.8 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000070601,FRMPD1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 11.9895% (minimum 75%, Missing); skeletal muscle: 69.4656% (minimum 75%, Missing); skin: 59.8684% (minimum 65%, Missing)",-0.0513158,0,-0.630105,0,2,partial,66.8,3.9,6.1,"retina: 66.8 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000070601,FRMPD1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 11.9895% (minimum 75%, Missing); skeletal muscle: 69.4656% (minimum 75%, Missing); skin: 59.8684% (minimum 65%, Missing)",-0.0513158,0,-0.630105,0,2,partial,66.8,3.9,6.1,"retina: 66.8 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000070601,FRMPD1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 11.9895% (minimum 75%, Missing); skeletal muscle: 69.4656% (minimum 75%, Missing); skin: 59.8684% (minimum 65%, Missing)",-0.0513158,0,-0.630105,0,2,partial,66.8,3.9,6.1,"retina: 66.8 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000070601,FRMPD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 11.9895% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 69.4656% (minimum 75%, Baseline (adaptation disabled)); skin: 59.8684% (minimum 65%, Baseline (adaptation disabled))",-0.0513158,0,-0.630105,0,2,partial,66.8,3.9,6.1,"retina: 66.8 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000070601,FRMPD1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.1818% (minimum 99%, Missing); amygdala: 67.7419% (minimum 99%, Missing); basal ganglia: 63.6364% (minimum 99%, Missing); cerebellum: 65.6250% (minimum 99%, Missing); cerebral cortex: 53.8462% (minimum 99%, Missing); choroid plexus: 6.0870% (minimum 99%, Missing); duodenum: 77.7778% (minimum 99%, Missing); hippocampal formation: 72.4138% (minimum 99%, Missing); hypothalamus: 43.7500% (minimum 99%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 39.6226% (minimum 99%, Missing); pituitary gland: 58.3333% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing); spinal cord: 72.4138% (minimum 99%, Missing); spleen: 31.8182% (minimum 95%, Missing)",-0.631818,0.03,-0.92913,0,80,unavailable,32.4,0,4.5,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000070886,EPHA8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.1818% (minimum 75%, Missing); amygdala: 67.7419% (minimum 75%, Missing); basal ganglia: 63.6364% (minimum 75%, Missing); cerebellum: 65.6250% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); choroid plexus: 6.0870% (minimum 75%, Missing); hippocampal formation: 72.4138% (minimum 75%, Missing); hypothalamus: 43.7500% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 39.6226% (minimum 75%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); spinal cord: 72.4138% (minimum 75%, Missing); spleen: 31.8182% (minimum 65%, Missing)",-0.331818,0.3,-0.68913,0,80,unavailable,32.4,0,4.5,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000070886,EPHA8,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.1818% (minimum 75%, Missing); amygdala: 67.7419% (minimum 75%, Missing); basal ganglia: 63.6364% (minimum 75%, Missing); cerebellum: 65.6250% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); choroid plexus: 6.0870% (minimum 75%, Missing); hippocampal formation: 72.4138% (minimum 75%, Missing); hypothalamus: 43.7500% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 39.6226% (minimum 75%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); spinal cord: 72.4138% (minimum 75%, Missing); spleen: 31.8182% (minimum 65%, Missing)",-0.331818,0.3,-0.68913,0,80,unavailable,32.4,0,4.5,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000070886,EPHA8,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.1818% (minimum 75%, Missing); amygdala: 67.7419% (minimum 75%, Missing); basal ganglia: 63.6364% (minimum 75%, Missing); cerebellum: 65.6250% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); choroid plexus: 6.0870% (minimum 75%, Missing); hippocampal formation: 72.4138% (minimum 75%, Missing); hypothalamus: 43.7500% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 39.6226% (minimum 75%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); spinal cord: 72.4138% (minimum 75%, Missing); spleen: 31.8182% (minimum 65%, Missing)",-0.331818,0.3,-0.68913,0,80,unavailable,32.4,0,4.5,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000070886,EPHA8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.1818% (minimum 75%, Baseline (adaptation disabled)); amygdala: 67.7419% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 63.6364% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.6250% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.8462% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 6.0870% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.4138% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 43.7500% (minimum 75%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 39.6226% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 58.3333% (minimum 75%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.4138% (minimum 75%, Baseline (adaptation disabled)); spleen: 31.8182% (minimum 65%, Baseline (adaptation disabled))",-0.331818,0.3,-0.68913,0,80,unavailable,32.4,0,4.5,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000070886,EPHA8,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.0265% (minimum 99%, Missing); basal ganglia: 97.3154% (minimum 99%, Missing); bone marrow: 83.0946% (minimum 95%, Enhanced); choroid plexus: 97.6431% (minimum 99%, Missing); colon: 88.6850% (minimum 97%, Missing); duodenum: 89.5062% (minimum 95%, Enhanced); hippocampal formation: 96.6667% (minimum 99%, Missing); hypothalamus: 95.7096% (minimum 99%, Missing); midbrain: 98.9761% (minimum 99%, Missing); pituitary gland: 94.7712% (minimum 99%, Missing); retina: 98.6395% (minimum 99%, Missing); skin: 92.6518% (minimum 95%, Missing); small intestine: 88.9571% (minimum 95%, Enhanced); smooth muscle: 89.5062% (minimum 95%, Enhanced); spinal cord: 98.9761% (minimum 99%, Missing); thymus: 76.3158% (minimum 95%, Missing)",-0.186842,-0.0831498,-0.119054,0,6,partial,5.9,7,9,"thymus: 9 nTPM (manageable, limit 5); colon: 3.7 nTPM (protected, limit 2); pituitary gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071539,TRIP13,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.113158,0.18685,0.197712,0,6,partial,5.9,7,9,"thymus: 9 nTPM (manageable, limit 5); colon: 3.7 nTPM (protected, limit 2); pituitary gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071539,TRIP13,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.113158,0.18685,0.197712,0,6,partial,5.9,7,9,"thymus: 9 nTPM (manageable, limit 5); colon: 3.7 nTPM (protected, limit 3); pituitary gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071539,TRIP13,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.113158,0.18685,0.197712,0,6,partial,5.9,7,9,"thymus: 9 nTPM (manageable, limit 5); colon: 3.7 nTPM (protected, limit 3); pituitary gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071539,TRIP13,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.113158,0.105556,0.0809456,0,6,partial,5.9,7,9,"thymus: 9 nTPM (manageable, limit 5); lymph node: 7 nTPM (protected, limit 3); bone marrow: 5.9 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 3); esophagus: 4.5 nTPM (protected, limit 3); colon: 3.7 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071539,TRIP13,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.8261% (minimum 95%, Missing); adrenal gland: 54.3412% (minimum 99%, Missing); amygdala: 41.3686% (minimum 99%, Missing); basal ganglia: 49.1682% (minimum 99%, Missing); bone marrow: 80.8511% (minimum 99%, Missing); cerebellum: 50.9579% (minimum 99%, Missing); cerebral cortex: 38.8038% (minimum 99%, Missing); choroid plexus: 93.0070% (minimum 99%, Missing); colon: 54.6201% (minimum 97%, Missing); duodenum: 87.7888% (minimum 99%, Missing); esophagus: 56.3559% (minimum 97%, Missing); heart muscle: 47.6703% (minimum 99%, Missing); hippocampal formation: 41.2084% (minimum 99%, Missing); hypothalamus: 53.5750% (minimum 99%, Missing); kidney: 54.6763% (minimum 99%, Missing); liver: 47.9279% (minimum 97%, Supported); lung: 58.9147% (minimum 99%, Missing); lymph node: 84.9840% (minimum 97%, Missing); midbrain: 52.5173% (minimum 99%, Missing); pancreas: 62.5882% (minimum 97%, Supported); parathyroid gland: 88.0795% (minimum 97%, Missing); pituitary gland: 52.2593% (minimum 99%, Missing); rectum: 89.5623% (minimum 97%, Missing); retina: 93.1699% (minimum 99%, Missing); salivary gland: 64.3289% (minimum 90%, Supported); skeletal muscle: 42.6966% (minimum 99%, Missing); skin: 57.7007% (minimum 95%, Missing); small intestine: 61.2903% (minimum 99%, Missing); smooth muscle: 88.2255% (minimum 99%, Missing); spinal cord: 57.7633% (minimum 99%, Missing); spleen: 52.2593% (minimum 95%, Missing); stomach: 58.4615% (minimum 97%, Missing); thymus: 85.8065% (minimum 95%, Missing); thyroid gland: 54.7889% (minimum 95%, Missing); tongue: 92.2010% (minimum 97%, Missing); urinary bladder: 57.2659% (minimum 97%, Missing)",-0.427407,-0.423799,-0.601962,0,3,partial,83.9,44.2,48.6,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 3); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); spleen: 48.6 nTPM (manageable, limit 5); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 2); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (manageable, limit 5); esophagus: 41.2 nTPM (protected, limit 2); urinary bladder: 39.7 nTPM (protected, limit 2); skin: 39 nTPM (manageable, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (manageable, limit 5); stomach: 37.8 nTPM (protected, limit 2); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 3); salivary gland: 29.5 nTPM (protected, limit 6); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 2); thymus: 8.8 nTPM (manageable, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 2); smooth muscle: 7.1 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); tongue: 4.5 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071655,MBD3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.8261% (minimum 65%, Missing); adrenal gland: 54.3412% (minimum 75%, Missing); amygdala: 41.3686% (minimum 75%, Missing); basal ganglia: 49.1682% (minimum 75%, Missing); cerebellum: 50.9579% (minimum 75%, Missing); cerebral cortex: 38.8038% (minimum 75%, Missing); colon: 54.6201% (minimum 70%, Missing); esophagus: 56.3559% (minimum 70%, Missing); heart muscle: 47.6703% (minimum 75%, Missing); hippocampal formation: 41.2084% (minimum 75%, Missing); hypothalamus: 53.5750% (minimum 75%, Missing); kidney: 54.6763% (minimum 75%, Missing); liver: 47.9279% (minimum 65%, Supported); lung: 58.9147% (minimum 75%, Missing); midbrain: 52.5173% (minimum 75%, Missing); pancreas: 62.5882% (minimum 65%, Supported); pituitary gland: 52.2593% (minimum 75%, Missing); skeletal muscle: 42.6966% (minimum 75%, Missing); skin: 57.7007% (minimum 65%, Missing); small intestine: 61.2903% (minimum 75%, Missing); spinal cord: 57.7633% (minimum 75%, Missing); spleen: 52.2593% (minimum 65%, Missing); stomach: 58.4615% (minimum 70%, Missing); thyroid gland: 54.7889% (minimum 65%, Missing); urinary bladder: 57.2659% (minimum 70%, Missing)",-0.127407,-0.153799,-0.361962,0,3,partial,83.9,44.2,48.6,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 3); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); spleen: 48.6 nTPM (manageable, limit 5); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 2); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (manageable, limit 5); esophagus: 41.2 nTPM (protected, limit 2); urinary bladder: 39.7 nTPM (protected, limit 2); skin: 39 nTPM (manageable, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (manageable, limit 5); stomach: 37.8 nTPM (protected, limit 2); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 3); salivary gland: 29.5 nTPM (protected, limit 6); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 2); thymus: 8.8 nTPM (manageable, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 2); smooth muscle: 7.1 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); tongue: 4.5 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071655,MBD3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.8261% (minimum 65%, Missing); adrenal gland: 54.3412% (minimum 75%, Missing); amygdala: 41.3686% (minimum 75%, Missing); basal ganglia: 49.1682% (minimum 75%, Missing); cerebellum: 50.9579% (minimum 75%, Missing); cerebral cortex: 38.8038% (minimum 75%, Missing); colon: 54.6201% (minimum 70%, Missing); esophagus: 56.3559% (minimum 70%, Missing); heart muscle: 47.6703% (minimum 75%, Missing); hippocampal formation: 41.2084% (minimum 75%, Missing); hypothalamus: 53.5750% (minimum 75%, Missing); kidney: 54.6763% (minimum 75%, Missing); liver: 47.9279% (minimum 65%, Supported); lung: 58.9147% (minimum 75%, Missing); midbrain: 52.5173% (minimum 75%, Missing); pancreas: 62.5882% (minimum 65%, Supported); pituitary gland: 52.2593% (minimum 75%, Missing); skeletal muscle: 42.6966% (minimum 75%, Missing); skin: 57.7007% (minimum 65%, Missing); small intestine: 61.2903% (minimum 75%, Missing); spinal cord: 57.7633% (minimum 75%, Missing); spleen: 52.2593% (minimum 65%, Missing); stomach: 58.4615% (minimum 70%, Missing); thyroid gland: 54.7889% (minimum 65%, Missing); urinary bladder: 57.2659% (minimum 70%, Missing)",-0.127407,-0.153799,-0.361962,0,3,partial,83.9,44.2,48.6,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 3); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); spleen: 48.6 nTPM (manageable, limit 5); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 3); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (manageable, limit 5); esophagus: 41.2 nTPM (protected, limit 3); urinary bladder: 39.7 nTPM (protected, limit 3); skin: 39 nTPM (manageable, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (manageable, limit 5); stomach: 37.8 nTPM (protected, limit 3); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 3); salivary gland: 29.5 nTPM (protected, limit 6); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 3); thymus: 8.8 nTPM (manageable, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 3); smooth muscle: 7.1 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); tongue: 4.5 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071655,MBD3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.8261% (minimum 65%, Missing); adrenal gland: 54.3412% (minimum 75%, Missing); amygdala: 41.3686% (minimum 75%, Missing); basal ganglia: 49.1682% (minimum 75%, Missing); cerebellum: 50.9579% (minimum 75%, Missing); cerebral cortex: 38.8038% (minimum 75%, Missing); colon: 54.6201% (minimum 70%, Missing); esophagus: 56.3559% (minimum 70%, Missing); heart muscle: 47.6703% (minimum 75%, Missing); hippocampal formation: 41.2084% (minimum 75%, Missing); hypothalamus: 53.5750% (minimum 75%, Missing); kidney: 54.6763% (minimum 75%, Missing); liver: 47.9279% (minimum 65%, Supported); lung: 58.9147% (minimum 75%, Missing); midbrain: 52.5173% (minimum 75%, Missing); pancreas: 62.5882% (minimum 65%, Supported); pituitary gland: 52.2593% (minimum 75%, Missing); skeletal muscle: 42.6966% (minimum 75%, Missing); skin: 57.7007% (minimum 65%, Missing); small intestine: 61.2903% (minimum 75%, Missing); spinal cord: 57.7633% (minimum 75%, Missing); spleen: 52.2593% (minimum 65%, Missing); stomach: 58.4615% (minimum 70%, Missing); thyroid gland: 54.7889% (minimum 65%, Missing); urinary bladder: 57.2659% (minimum 70%, Missing)",-0.127407,-0.153799,-0.361962,0,3,partial,83.9,44.2,48.6,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 3); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); spleen: 48.6 nTPM (manageable, limit 5); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 3); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (manageable, limit 5); esophagus: 41.2 nTPM (protected, limit 3); urinary bladder: 39.7 nTPM (protected, limit 3); skin: 39 nTPM (manageable, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (manageable, limit 5); stomach: 37.8 nTPM (protected, limit 3); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 3); salivary gland: 29.5 nTPM (protected, limit 6); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 3); thymus: 8.8 nTPM (manageable, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 3); smooth muscle: 7.1 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); tongue: 4.5 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071655,MBD3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.8261% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 54.3412% (minimum 75%, Baseline (adaptation disabled)); amygdala: 41.3686% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 49.1682% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 50.9579% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 38.8038% (minimum 75%, Baseline (adaptation disabled)); colon: 54.6201% (minimum 70%, Baseline (adaptation disabled)); esophagus: 56.3559% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 47.6703% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 41.2084% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.5750% (minimum 75%, Baseline (adaptation disabled)); kidney: 54.6763% (minimum 75%, Baseline (adaptation disabled)); liver: 47.9279% (minimum 75%, Baseline (adaptation disabled)); lung: 58.9147% (minimum 75%, Baseline (adaptation disabled)); midbrain: 52.5173% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.5882% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 52.2593% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.3289% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 42.6966% (minimum 75%, Baseline (adaptation disabled)); skin: 57.7007% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.2903% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.7633% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.2593% (minimum 65%, Baseline (adaptation disabled)); stomach: 58.4615% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 54.7889% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 57.2659% (minimum 70%, Baseline (adaptation disabled))",-0.127407,-0.153799,-0.361962,0,3,partial,83.9,44.2,48.6,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 1); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); spleen: 48.6 nTPM (manageable, limit 5); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 3); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (manageable, limit 5); esophagus: 41.2 nTPM (protected, limit 3); urinary bladder: 39.7 nTPM (protected, limit 3); skin: 39 nTPM (manageable, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (manageable, limit 5); stomach: 37.8 nTPM (protected, limit 3); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 1); salivary gland: 29.5 nTPM (protected, limit 3); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 3); thymus: 8.8 nTPM (manageable, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 3); smooth muscle: 7.1 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); tongue: 4.5 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071655,MBD3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 72.8723% (minimum 98%, Approved); pancreas: 97.1631% (minimum 98%, Approved); parathyroid gland: 61.7117% (minimum 97%, Missing); pituitary gland: 97.8571% (minimum 99%, Missing); retina: 70.6186% (minimum 99%, Missing); urinary bladder: 86.7089% (minimum 95%, Approved)",0.0194631,-0.352883,-0.283814,0,1,partial,5.7,8.5,1.2,"parathyroid gland: 8.5 nTPM (protected, limit 2); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 2)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071909,MYO3B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"parathyroid gland: 61.7117% (minimum 70%, Missing); retina: 70.6186% (minimum 75%, Missing)",0.319463,-0.0828829,-0.0438144,0,1,partial,5.7,8.5,1.2,"parathyroid gland: 8.5 nTPM (protected, limit 2); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 2)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071909,MYO3B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"parathyroid gland: 61.7117% (minimum 70%, Missing); retina: 70.6186% (minimum 75%, Missing)",0.319463,-0.0828829,-0.0438144,0,1,partial,5.7,8.5,1.2,"parathyroid gland: 8.5 nTPM (protected, limit 3); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 2)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071909,MYO3B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"parathyroid gland: 61.7117% (minimum 70%, Missing); retina: 70.6186% (minimum 75%, Missing)",0.319463,-0.0828829,-0.0438144,0,1,partial,5.7,8.5,1.2,"parathyroid gland: 8.5 nTPM (protected, limit 3); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 2)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071909,MYO3B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 72.8723% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.7117% (minimum 70%, Baseline (adaptation disabled)); retina: 70.6186% (minimum 75%, Baseline (adaptation disabled))",0.269463,-0.0828829,-0.0438144,0,1,partial,5.7,8.5,1.2,"parathyroid gland: 8.5 nTPM (protected, limit 3); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000071909,MYO3B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.4839% (minimum 95%, Missing); adrenal gland: 48.4962% (minimum 99%, Missing); amygdala: 71.0744% (minimum 99%, Missing); basal ganglia: 68.0739% (minimum 99%, Missing); bone marrow: 37.5000% (minimum 99%, Missing); cerebellum: 57.4610% (minimum 99%, Missing); cerebral cortex: 56.3319% (minimum 99%, Missing); choroid plexus: 75.6598% (minimum 99%, Missing); colon: 59.1743% (minimum 97%, Missing); duodenum: 64.8241% (minimum 99%, Missing); esophagus: 49.9033% (minimum 97%, Missing); heart muscle: 61.8705% (minimum 99%, Missing); hippocampal formation: 70.8791% (minimum 99%, Missing); hypothalamus: 67.8947% (minimum 99%, Missing); kidney: 52.4390% (minimum 99%, Missing); liver: 55.7235% (minimum 99%, Missing); lung: 57.4610% (minimum 99%, Missing); lymph node: 63.0807% (minimum 97%, Missing); midbrain: 71.6667% (minimum 99%, Missing); pancreas: 51.7034% (minimum 99%, Missing); parathyroid gland: 42.3645% (minimum 97%, Missing); pituitary gland: 57.5893% (minimum 99%, Missing); rectum: 60.2804% (minimum 97%, Missing); retina: 35.9833% (minimum 99%, Missing); salivary gland: 58.2393% (minimum 97%, Missing); skeletal muscle: 51.2922% (minimum 99%, Missing); skin: 59.0389% (minimum 95%, Missing); small intestine: 63.8614% (minimum 99%, Missing); smooth muscle: 53.0864% (minimum 99%, Missing); spinal cord: 67.1875% (minimum 99%, Missing); spleen: 61.1374% (minimum 95%, Missing); stomach: 51.2922% (minimum 97%, Missing); thymus: 58.2393% (minimum 95%, Missing); thyroid gland: 44.4828% (minimum 95%, Missing); tongue: 51.1905% (minimum 97%, Missing); urinary bladder: 53.7500% (minimum 97%, Missing)",-0.505172,-0.546355,-0.630167,0,7,partial,45.9,35.1,32.2,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 2); thyroid gland: 32.2 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 2); tongue: 24.6 nTPM (protected, limit 2); stomach: 24.5 nTPM (protected, limit 2); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 2); adipose tissue: 20.7 nTPM (manageable, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); salivary gland: 18.5 nTPM (protected, limit 2); thymus: 18.5 nTPM (manageable, limit 5); skin: 17.9 nTPM (manageable, limit 5); colon: 17.8 nTPM (protected, limit 2); rectum: 17 nTPM (protected, limit 2); spleen: 16.4 nTPM (manageable, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 2); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000072364,AFF4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.4839% (minimum 65%, Missing); adrenal gland: 48.4962% (minimum 75%, Missing); amygdala: 71.0744% (minimum 75%, Missing); basal ganglia: 68.0739% (minimum 75%, Missing); bone marrow: 37.5000% (minimum 75%, Missing); cerebellum: 57.4610% (minimum 75%, Missing); cerebral cortex: 56.3319% (minimum 75%, Missing); colon: 59.1743% (minimum 70%, Missing); duodenum: 64.8241% (minimum 75%, Missing); esophagus: 49.9033% (minimum 70%, Missing); heart muscle: 61.8705% (minimum 75%, Missing); hippocampal formation: 70.8791% (minimum 75%, Missing); hypothalamus: 67.8947% (minimum 75%, Missing); kidney: 52.4390% (minimum 75%, Missing); liver: 55.7235% (minimum 75%, Missing); lung: 57.4610% (minimum 75%, Missing); lymph node: 63.0807% (minimum 70%, Missing); midbrain: 71.6667% (minimum 75%, Missing); pancreas: 51.7034% (minimum 75%, Missing); parathyroid gland: 42.3645% (minimum 70%, Missing); pituitary gland: 57.5893% (minimum 75%, Missing); rectum: 60.2804% (minimum 70%, Missing); retina: 35.9833% (minimum 75%, Missing); salivary gland: 58.2393% (minimum 70%, Missing); skeletal muscle: 51.2922% (minimum 75%, Missing); skin: 59.0389% (minimum 65%, Missing); small intestine: 63.8614% (minimum 75%, Missing); smooth muscle: 53.0864% (minimum 75%, Missing); spinal cord: 67.1875% (minimum 75%, Missing); spleen: 61.1374% (minimum 65%, Missing); stomach: 51.2922% (minimum 70%, Missing); thymus: 58.2393% (minimum 65%, Missing); thyroid gland: 44.4828% (minimum 65%, Missing); tongue: 51.1905% (minimum 70%, Missing); urinary bladder: 53.7500% (minimum 70%, Missing)",-0.205172,-0.276355,-0.390167,0,7,partial,45.9,35.1,32.2,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 2); thyroid gland: 32.2 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 2); tongue: 24.6 nTPM (protected, limit 2); stomach: 24.5 nTPM (protected, limit 2); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 2); adipose tissue: 20.7 nTPM (manageable, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); salivary gland: 18.5 nTPM (protected, limit 2); thymus: 18.5 nTPM (manageable, limit 5); skin: 17.9 nTPM (manageable, limit 5); colon: 17.8 nTPM (protected, limit 2); rectum: 17 nTPM (protected, limit 2); spleen: 16.4 nTPM (manageable, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 2); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000072364,AFF4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.4839% (minimum 65%, Missing); adrenal gland: 48.4962% (minimum 75%, Missing); amygdala: 71.0744% (minimum 75%, Missing); basal ganglia: 68.0739% (minimum 75%, Missing); bone marrow: 37.5000% (minimum 75%, Missing); cerebellum: 57.4610% (minimum 75%, Missing); cerebral cortex: 56.3319% (minimum 75%, Missing); colon: 59.1743% (minimum 70%, Missing); duodenum: 64.8241% (minimum 75%, Missing); esophagus: 49.9033% (minimum 70%, Missing); heart muscle: 61.8705% (minimum 75%, Missing); hippocampal formation: 70.8791% (minimum 75%, Missing); hypothalamus: 67.8947% (minimum 75%, Missing); kidney: 52.4390% (minimum 75%, Missing); liver: 55.7235% (minimum 75%, Missing); lung: 57.4610% (minimum 75%, Missing); lymph node: 63.0807% (minimum 70%, Missing); midbrain: 71.6667% (minimum 75%, Missing); pancreas: 51.7034% (minimum 75%, Missing); parathyroid gland: 42.3645% (minimum 70%, Missing); pituitary gland: 57.5893% (minimum 75%, Missing); rectum: 60.2804% (minimum 70%, Missing); retina: 35.9833% (minimum 75%, Missing); salivary gland: 58.2393% (minimum 70%, Missing); skeletal muscle: 51.2922% (minimum 75%, Missing); skin: 59.0389% (minimum 65%, Missing); small intestine: 63.8614% (minimum 75%, Missing); smooth muscle: 53.0864% (minimum 75%, Missing); spinal cord: 67.1875% (minimum 75%, Missing); spleen: 61.1374% (minimum 65%, Missing); stomach: 51.2922% (minimum 70%, Missing); thymus: 58.2393% (minimum 65%, Missing); thyroid gland: 44.4828% (minimum 65%, Missing); tongue: 51.1905% (minimum 70%, Missing); urinary bladder: 53.7500% (minimum 70%, Missing)",-0.205172,-0.276355,-0.390167,0,7,partial,45.9,35.1,32.2,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 3); thyroid gland: 32.2 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 3); tongue: 24.6 nTPM (protected, limit 3); stomach: 24.5 nTPM (protected, limit 3); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 3); adipose tissue: 20.7 nTPM (manageable, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); salivary gland: 18.5 nTPM (protected, limit 3); thymus: 18.5 nTPM (manageable, limit 5); skin: 17.9 nTPM (manageable, limit 5); colon: 17.8 nTPM (protected, limit 3); rectum: 17 nTPM (protected, limit 3); spleen: 16.4 nTPM (manageable, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 3); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000072364,AFF4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.4839% (minimum 65%, Missing); adrenal gland: 48.4962% (minimum 75%, Missing); amygdala: 71.0744% (minimum 75%, Missing); basal ganglia: 68.0739% (minimum 75%, Missing); bone marrow: 37.5000% (minimum 75%, Missing); cerebellum: 57.4610% (minimum 75%, Missing); cerebral cortex: 56.3319% (minimum 75%, Missing); colon: 59.1743% (minimum 70%, Missing); duodenum: 64.8241% (minimum 75%, Missing); esophagus: 49.9033% (minimum 70%, Missing); heart muscle: 61.8705% (minimum 75%, Missing); hippocampal formation: 70.8791% (minimum 75%, Missing); hypothalamus: 67.8947% (minimum 75%, Missing); kidney: 52.4390% (minimum 75%, Missing); liver: 55.7235% (minimum 75%, Missing); lung: 57.4610% (minimum 75%, Missing); lymph node: 63.0807% (minimum 70%, Missing); midbrain: 71.6667% (minimum 75%, Missing); pancreas: 51.7034% (minimum 75%, Missing); parathyroid gland: 42.3645% (minimum 70%, Missing); pituitary gland: 57.5893% (minimum 75%, Missing); rectum: 60.2804% (minimum 70%, Missing); retina: 35.9833% (minimum 75%, Missing); salivary gland: 58.2393% (minimum 70%, Missing); skeletal muscle: 51.2922% (minimum 75%, Missing); skin: 59.0389% (minimum 65%, Missing); small intestine: 63.8614% (minimum 75%, Missing); smooth muscle: 53.0864% (minimum 75%, Missing); spinal cord: 67.1875% (minimum 75%, Missing); spleen: 61.1374% (minimum 65%, Missing); stomach: 51.2922% (minimum 70%, Missing); thymus: 58.2393% (minimum 65%, Missing); thyroid gland: 44.4828% (minimum 65%, Missing); tongue: 51.1905% (minimum 70%, Missing); urinary bladder: 53.7500% (minimum 70%, Missing)",-0.205172,-0.276355,-0.390167,0,7,partial,45.9,35.1,32.2,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 3); thyroid gland: 32.2 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 3); tongue: 24.6 nTPM (protected, limit 3); stomach: 24.5 nTPM (protected, limit 3); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 3); adipose tissue: 20.7 nTPM (manageable, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); salivary gland: 18.5 nTPM (protected, limit 3); thymus: 18.5 nTPM (manageable, limit 5); skin: 17.9 nTPM (manageable, limit 5); colon: 17.8 nTPM (protected, limit 3); rectum: 17 nTPM (protected, limit 3); spleen: 16.4 nTPM (manageable, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 3); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000072364,AFF4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.4839% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 48.4962% (minimum 75%, Baseline (adaptation disabled)); amygdala: 71.0744% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 68.0739% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 37.5000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.4610% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.3319% (minimum 75%, Baseline (adaptation disabled)); colon: 59.1743% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.8241% (minimum 75%, Baseline (adaptation disabled)); esophagus: 49.9033% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 61.8705% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.8791% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.8947% (minimum 75%, Baseline (adaptation disabled)); kidney: 52.4390% (minimum 75%, Baseline (adaptation disabled)); liver: 55.7235% (minimum 75%, Baseline (adaptation disabled)); lung: 57.4610% (minimum 75%, Baseline (adaptation disabled)); lymph node: 63.0807% (minimum 70%, Baseline (adaptation disabled)); midbrain: 71.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 51.7034% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 42.3645% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 57.5893% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.2804% (minimum 70%, Baseline (adaptation disabled)); retina: 35.9833% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.2393% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 51.2922% (minimum 75%, Baseline (adaptation disabled)); skin: 59.0389% (minimum 65%, Baseline (adaptation disabled)); small intestine: 63.8614% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.0864% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.1875% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.1374% (minimum 65%, Baseline (adaptation disabled)); stomach: 51.2922% (minimum 70%, Baseline (adaptation disabled)); thymus: 58.2393% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 44.4828% (minimum 65%, Baseline (adaptation disabled)); tongue: 51.1905% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 53.7500% (minimum 70%, Baseline (adaptation disabled))",-0.205172,-0.276355,-0.390167,0,7,partial,45.9,35.1,32.2,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 3); thyroid gland: 32.2 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 3); tongue: 24.6 nTPM (protected, limit 3); stomach: 24.5 nTPM (protected, limit 3); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 3); adipose tissue: 20.7 nTPM (manageable, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); salivary gland: 18.5 nTPM (protected, limit 3); thymus: 18.5 nTPM (manageable, limit 5); skin: 17.9 nTPM (manageable, limit 5); colon: 17.8 nTPM (protected, limit 3); rectum: 17 nTPM (protected, limit 3); spleen: 16.4 nTPM (manageable, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 3); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000072364,AFF4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.8085% (minimum 99%, Missing); cerebral cortex: 96.0432% (minimum 99%, Missing); colon: 80.9091% (minimum 97%, Missing); duodenum: 78.7611% (minimum 99%, Missing); hippocampal formation: 98.8889% (minimum 99%, Missing); hypothalamus: 98.8889% (minimum 99%, Missing); liver: 94.0141% (minimum 95%, Enhanced); lymph node: 60.1351% (minimum 97%, Missing); midbrain: 98.5240% (minimum 99%, Missing); rectum: 75.8523% (minimum 97%, Missing); retina: 97.0909% (minimum 99%, Missing); skin: 86.6883% (minimum 95%, Missing); small intestine: 80.9091% (minimum 95%, Enhanced); smooth muscle: 90.5085% (minimum 95%, Enhanced); spinal cord: 96.7391% (minimum 99%, Missing); stomach: 88.4106% (minimum 97%, Missing); thymus: 50.1880% (minimum 95%, Missing)",-0.44812,-0.368649,-0.421915,0,6,partial,20.3,17.7,26.5,"thymus: 26.5 nTPM (manageable, limit 5); bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 2); rectum: 8.5 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); small intestine: 6.3 nTPM (vital, limit 6); stomach: 3.5 nTPM (protected, limit 2); cerebral cortex: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / sebaceous glands: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / sebaceous glands; skin 2 / cells in spinous layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000072571,HMMR,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.8085% (minimum 75%, Missing); lymph node: 60.1351% (minimum 70%, Missing); thymus: 50.1880% (minimum 65%, Missing)",-0.14812,-0.0986486,-0.181915,0,6,partial,20.3,17.7,26.5,"thymus: 26.5 nTPM (manageable, limit 5); bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 2); rectum: 8.5 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); small intestine: 6.3 nTPM (vital, limit 6); stomach: 3.5 nTPM (protected, limit 2); cerebral cortex: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / sebaceous glands: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / sebaceous glands; skin 2 / cells in spinous layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000072571,HMMR,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.8085% (minimum 75%, Missing); lymph node: 60.1351% (minimum 70%, Missing); thymus: 50.1880% (minimum 65%, Missing)",-0.14812,-0.0986486,-0.181915,0,6,partial,20.3,17.7,26.5,"thymus: 26.5 nTPM (manageable, limit 5); bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 3); rectum: 8.5 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); small intestine: 6.3 nTPM (vital, limit 6); stomach: 3.5 nTPM (protected, limit 3); cerebral cortex: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / sebaceous glands: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / sebaceous glands; skin 2 / cells in spinous layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000072571,HMMR,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.8085% (minimum 75%, Missing); lymph node: 60.1351% (minimum 70%, Missing); thymus: 50.1880% (minimum 65%, Missing)",-0.14812,-0.0986486,-0.181915,0,6,partial,20.3,17.7,26.5,"thymus: 26.5 nTPM (manageable, limit 5); bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 3); rectum: 8.5 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); small intestine: 6.3 nTPM (vital, limit 6); stomach: 3.5 nTPM (protected, limit 3); cerebral cortex: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / sebaceous glands: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / sebaceous glands; skin 2 / cells in spinous layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000072571,HMMR,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.8085% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.1351% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.1880% (minimum 65%, Baseline (adaptation disabled))",-0.14812,-0.0986486,-0.181915,0,6,partial,20.3,17.7,26.5,"thymus: 26.5 nTPM (manageable, limit 5); bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 3); rectum: 8.5 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); small intestine: 6.3 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 2.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / sebaceous glands: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / sebaceous glands; skin 2 / cells in spinous layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000072571,HMMR,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.1831% (minimum 99%, Missing); basal ganglia: 96.7290% (minimum 99%, Missing); cerebellum: 94.9541% (minimum 98%, Approved); cerebral cortex: 96.2791% (minimum 98%, Approved); choroid plexus: 98.8067% (minimum 99%, Missing); hippocampal formation: 97.6415% (minimum 99%, Missing); hypothalamus: 97.4118% (minimum 99%, Missing); midbrain: 97.4118% (minimum 99%, Missing); pituitary gland: 97.6415% (minimum 99%, Missing); retina: 96.9555% (minimum 99%, Missing); small intestine: 97.4118% (minimum 98%, Approved); smooth muscle: 96.5035% (minimum 98%, Approved); spinal cord: 96.5035% (minimum 99%, Missing)",0.05,0.00612009,-0.0304587,0,0,routine_complete,2.2,1.9,0.5,"cerebellum: 2.2 nTPM (vital, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000073146,MOV10L1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.215035,0,0,routine_complete,2.2,1.9,0.5,"cerebellum: 2.2 nTPM (vital, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000073146,MOV10L1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.215035,0,0,routine_complete,2.2,1.9,0.5,"cerebellum: 2.2 nTPM (vital, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000073146,MOV10L1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.215035,0,0,routine_complete,2.2,1.9,0.5,"cerebellum: 2.2 nTPM (vital, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000073146,MOV10L1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338067,0.25612,0.199541,0,0,routine_complete,2.2,1.9,0.5,"cerebellum: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000073146,MOV10L1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000073598,FNDC8,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000073598,FNDC8,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000073598,FNDC8,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000073598,FNDC8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348845,0.298845,0.25,0,1,partial,0,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000073598,FNDC8,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 82.2314% (minimum 95%, Enhanced); amygdala: 83.6134% (minimum 99%, Missing); basal ganglia: 83.9662% (minimum 99%, Missing); bone marrow: 61.4198% (minimum 99%, Missing); cerebellum: 83.9662% (minimum 95%, Enhanced); cerebral cortex: 81.5574% (minimum 95%, Enhanced); choroid plexus: 83.9662% (minimum 99%, Missing); colon: 81.2245% (minimum 97%, Missing); duodenum: 88.0531% (minimum 99%, Missing); esophagus: 80.5668% (minimum 97%, Missing); heart muscle: 86.8996% (minimum 95%, Enhanced); hippocampal formation: 84.6809% (minimum 99%, Missing); hypothalamus: 82.9167% (minimum 99%, Missing); kidney: 83.6134% (minimum 95%, Enhanced); liver: 80.5668% (minimum 95%, Enhanced); lung: 85.4077% (minimum 95%, Enhanced); lymph node: 68.3849% (minimum 97%, Missing); midbrain: 83.6134% (minimum 99%, Missing); pancreas: 81.5574% (minimum 95%, Enhanced); parathyroid gland: 79.9197% (minimum 80%, Enhanced); pituitary gland: 86.5217% (minimum 99%, Missing); rectum: 79.6000% (minimum 97%, Missing); retina: 71.8412% (minimum 99%, Missing); skeletal muscle: 83.6134% (minimum 95%, Enhanced); skin: 83.9662% (minimum 95%, Missing); small intestine: 87.2807% (minimum 99%, Missing); smooth muscle: 82.2314% (minimum 95%, Enhanced); spinal cord: 83.2636% (minimum 99%, Missing); spleen: 84.6809% (minimum 95%, Missing); stomach: 84.3220% (minimum 97%, Missing); thymus: 72.3636% (minimum 95%, Missing); tongue: 81.2245% (minimum 97%, Missing); urinary bladder: 85.4077% (minimum 97%, Missing)",-0.226364,-0.286151,-0.375802,0,2,partial,12.5,9.2,7.6,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 2); retina: 7.8 nTPM (vital, limit 1); thymus: 7.6 nTPM (manageable, limit 5); rectum: 5.1 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); tongue: 4.6 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075131,TIPIN,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 61.4198% (minimum 75%, Missing); lymph node: 68.3849% (minimum 70%, Missing); retina: 71.8412% (minimum 75%, Missing)",0.0736364,-0.0161512,-0.135802,0,2,partial,12.5,9.2,7.6,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 2); retina: 7.8 nTPM (vital, limit 1); thymus: 7.6 nTPM (manageable, limit 5); rectum: 5.1 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); tongue: 4.6 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075131,TIPIN,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 61.4198% (minimum 75%, Missing); lymph node: 68.3849% (minimum 70%, Missing); retina: 71.8412% (minimum 75%, Missing)",0.0736364,-0.0161512,-0.135802,0,2,partial,12.5,9.2,7.6,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 3); retina: 7.8 nTPM (vital, limit 1); thymus: 7.6 nTPM (manageable, limit 5); rectum: 5.1 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); tongue: 4.6 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075131,TIPIN,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 61.4198% (minimum 75%, Missing); lymph node: 68.3849% (minimum 70%, Missing); retina: 71.8412% (minimum 75%, Missing)",0.0736364,-0.0161512,-0.135802,0,2,partial,12.5,9.2,7.6,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 3); retina: 7.8 nTPM (vital, limit 1); thymus: 7.6 nTPM (manageable, limit 5); rectum: 5.1 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); tongue: 4.6 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075131,TIPIN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 61.4198% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.3849% (minimum 70%, Baseline (adaptation disabled)); retina: 71.8412% (minimum 75%, Baseline (adaptation disabled))",0.0736364,-0.0161512,-0.135802,0,2,partial,12.5,9.2,7.6,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 3); retina: 7.8 nTPM (vital, limit 1); thymus: 7.6 nTPM (manageable, limit 5); rectum: 5.1 nTPM (protected, limit 3); parathyroid gland: 5 nTPM (protected, limit 3); liver: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); tongue: 4.6 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); lung: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075131,TIPIN,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Missing); adrenal gland: 92.1053% (minimum 99%, Missing); basal ganglia: 98.5915% (minimum 99%, Missing); bone marrow: 38.8889% (minimum 99%, Missing); cerebellum: 97.2222% (minimum 99%, Missing); cerebral cortex: 93.3333% (minimum 99%, Missing); choroid plexus: 95.8904% (minimum 99%, Missing); colon: 75.2688% (minimum 97%, Missing); duodenum: 63.6364% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 95.8904% (minimum 99%, Missing); hippocampal formation: 98.5915% (minimum 99%, Missing); hypothalamus: 98.5915% (minimum 99%, Missing); kidney: 95.8904% (minimum 99%, Missing); liver: 94.5946% (minimum 99%, Missing); lung: 92.1053% (minimum 99%, Missing); lymph node: 43.7500% (minimum 97%, Missing); midbrain: 98.5915% (minimum 99%, Missing); pancreas: 97.2222% (minimum 99%, Missing); pituitary gland: 98.5915% (minimum 99%, Missing); rectum: 73.6842% (minimum 97%, Missing); retina: 98.5915% (minimum 99%, Missing); salivary gland: 92.1053% (minimum 97%, Missing); skeletal muscle: 98.5915% (minimum 99%, Missing); skin: 74.4681% (minimum 95%, Missing); small intestine: 71.4286% (minimum 99%, Missing); smooth muscle: 86.4198% (minimum 99%, Missing); spinal cord: 97.2222% (minimum 99%, Missing); spleen: 74.4681% (minimum 95%, Missing); stomach: 79.5455% (minimum 97%, Missing); thymus: 26.8199% (minimum 95%, Missing); urinary bladder: 88.6076% (minimum 97%, Missing)",-0.681801,-0.5325,-0.601111,0,80,unavailable,11,9,19.1,"thymus: 19.1 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075218,GTSE1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 38.8889% (minimum 75%, Missing); duodenum: 63.6364% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 43.7500% (minimum 70%, Missing); small intestine: 71.4286% (minimum 75%, Missing); thymus: 26.8199% (minimum 65%, Missing)",-0.381801,-0.2625,-0.361111,0,80,unavailable,11,9,19.1,"thymus: 19.1 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075218,GTSE1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 38.8889% (minimum 75%, Missing); duodenum: 63.6364% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 43.7500% (minimum 70%, Missing); small intestine: 71.4286% (minimum 75%, Missing); thymus: 26.8199% (minimum 65%, Missing)",-0.381801,-0.2625,-0.361111,0,80,unavailable,11,9,19.1,"thymus: 19.1 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075218,GTSE1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 38.8889% (minimum 75%, Missing); duodenum: 63.6364% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 43.7500% (minimum 70%, Missing); small intestine: 71.4286% (minimum 75%, Missing); thymus: 26.8199% (minimum 65%, Missing)",-0.381801,-0.2625,-0.361111,0,80,unavailable,11,9,19.1,"thymus: 19.1 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075218,GTSE1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 38.8889% (minimum 75%, Baseline (adaptation disabled)); duodenum: 63.6364% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); lymph node: 43.7500% (minimum 70%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 75%, Baseline (adaptation disabled)); thymus: 26.8199% (minimum 65%, Baseline (adaptation disabled))",-0.381801,-0.2625,-0.361111,0,80,unavailable,11,9,19.1,"thymus: 19.1 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075218,GTSE1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075388,FGF4,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075388,FGF4,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075388,FGF4,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075388,FGF4,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075388,FGF4,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 92.1131% (minimum 99%, Missing); heart muscle: 74.3097% (minimum 95%, Enhanced); lymph node: 95.5247% (minimum 97%, Missing); retina: 90.4971% (minimum 99%, Missing); skeletal muscle: 36.7577% (minimum 95%, Enhanced); thymus: 92.8036% (minimum 95%, Missing); tongue: 50.5306% (minimum 97%, Missing)",-0.021964,-0.464694,-0.582423,0,6,partial,106.5,60.6,4.8,"skeletal muscle: 106.5 nTPM (vital, limit 6); tongue: 60.6 nTPM (protected, limit 2); heart muscle: 21.4 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075702,WDR62,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 36.7577% (minimum 60%, Enhanced); tongue: 50.5306% (minimum 70%, Missing)",0.278036,-0.194694,-0.232423,0,6,partial,106.5,60.6,4.8,"skeletal muscle: 106.5 nTPM (vital, limit 6); tongue: 60.6 nTPM (protected, limit 2); heart muscle: 21.4 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075702,WDR62,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 36.7577% (minimum 60%, Enhanced); tongue: 50.5306% (minimum 70%, Missing)",0.278036,-0.194694,-0.232423,0,6,partial,106.5,60.6,4.8,"skeletal muscle: 106.5 nTPM (vital, limit 6); tongue: 60.6 nTPM (protected, limit 3); heart muscle: 21.4 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075702,WDR62,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 36.7577% (minimum 60%, Enhanced); tongue: 50.5306% (minimum 70%, Missing)",0.278036,-0.194694,-0.232423,0,6,partial,106.5,60.6,4.8,"skeletal muscle: 106.5 nTPM (vital, limit 6); tongue: 60.6 nTPM (protected, limit 3); heart muscle: 21.4 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075702,WDR62,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 74.3097% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 36.7577% (minimum 75%, Baseline (adaptation disabled)); tongue: 50.5306% (minimum 70%, Baseline (adaptation disabled))",0.278036,-0.194694,-0.382423,0,6,partial,106.5,60.6,4.8,"skeletal muscle: 106.5 nTPM (vital, limit 1); tongue: 60.6 nTPM (protected, limit 3); heart muscle: 21.4 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); duodenum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075702,WDR62,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 71.9664% (minimum 99%, Missing)",0.0472054,0.0281352,-0.270336,0,80,unavailable,83.4,0.4,0.6,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075886,TUBA3D,admission_only,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 71.9664% (minimum 75%, Missing)",0.347205,0.298135,-0.0303361,0,80,unavailable,83.4,0.4,0.6,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075886,TUBA3D,selectivity_revised,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 71.9664% (minimum 75%, Missing)",0.347205,0.298135,-0.0303361,0,80,unavailable,83.4,0.4,0.6,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075886,TUBA3D,grid_revised,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 71.9664% (minimum 75%, Missing)",0.347205,0.298135,-0.0303361,0,80,unavailable,83.4,0.4,0.6,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075886,TUBA3D,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 71.9664% (minimum 75%, Baseline (adaptation disabled))",0.347205,0.298135,-0.0303361,0,80,unavailable,83.4,0.4,0.6,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000075886,TUBA3D,current_fixed,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0414% (minimum 95%, Missing); adrenal gland: 64.3725% (minimum 99%, Missing); amygdala: 76.4423% (minimum 99%, Missing); basal ganglia: 73.6111% (minimum 99%, Missing); bone marrow: 28.8566% (minimum 99%, Missing); cerebellum: 74.6479% (minimum 99%, Missing); cerebral cortex: 79.1045% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 55.5944% (minimum 97%, Missing); duodenum: 72.6027% (minimum 99%, Missing); esophagus: 55.0173% (minimum 97%, Missing); heart muscle: 62.3529% (minimum 99%, Missing); hippocampal formation: 76.4423% (minimum 99%, Missing); hypothalamus: 77.9412% (minimum 99%, Missing); kidney: 56.3830% (minimum 99%, Missing); liver: 47.7477% (minimum 99%, Missing); lung: 54.4521% (minimum 99%, Missing); lymph node: 70.6667% (minimum 97%, Missing); midbrain: 75.7143% (minimum 99%, Missing); pancreas: 62.1094% (minimum 97%, Supported); parathyroid gland: 63.3466% (minimum 97%, Missing); pituitary gland: 69.4323% (minimum 99%, Missing); rectum: 59.5506% (minimum 97%, Missing); retina: 70.6667% (minimum 99%, Missing); salivary gland: 56.3830% (minimum 97%, Missing); skeletal muscle: 57.6087% (minimum 99%, Missing); skin: 60.2273% (minimum 95%, Missing); small intestine: 59.1078% (minimum 99%, Missing); smooth muscle: 60.2273% (minimum 99%, Missing); spinal cord: 71.9457% (minimum 99%, Missing); spleen: 61.8677% (minimum 95%, Missing); stomach: 57.4007% (minimum 97%, Missing); thymus: 51.7915% (minimum 95%, Missing); thyroid gland: 61.1538% (minimum 95%, Missing); tongue: 53.3557% (minimum 97%, Missing); urinary bladder: 56.5836% (minimum 97%, Missing)",-0.479586,-0.436443,-0.701434,0,8,partial,39.2,13.9,17.9,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (manageable, limit 5); liver: 17.4 nTPM (vital, limit 1); thymus: 14.8 nTPM (manageable, limit 5); tongue: 13.9 nTPM (protected, limit 2); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 2); colon: 12.7 nTPM (protected, limit 2); salivary gland: 12.3 nTPM (protected, limit 2); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); stomach: 11.8 nTPM (protected, limit 2); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 2); smooth muscle: 10.5 nTPM (vital, limit 1); skin: 10.5 nTPM (manageable, limit 5); thyroid gland: 10.1 nTPM (manageable, limit 5); spleen: 9.8 nTPM (manageable, limit 5); pancreas: 9.7 nTPM (vital, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000076053,RBM7,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0414% (minimum 65%, Missing); adrenal gland: 64.3725% (minimum 75%, Missing); basal ganglia: 73.6111% (minimum 75%, Missing); bone marrow: 28.8566% (minimum 75%, Missing); cerebellum: 74.6479% (minimum 75%, Missing); colon: 55.5944% (minimum 70%, Missing); duodenum: 72.6027% (minimum 75%, Missing); esophagus: 55.0173% (minimum 70%, Missing); heart muscle: 62.3529% (minimum 75%, Missing); kidney: 56.3830% (minimum 75%, Missing); liver: 47.7477% (minimum 75%, Missing); lung: 54.4521% (minimum 75%, Missing); pancreas: 62.1094% (minimum 65%, Supported); parathyroid gland: 63.3466% (minimum 70%, Missing); pituitary gland: 69.4323% (minimum 75%, Missing); rectum: 59.5506% (minimum 70%, Missing); retina: 70.6667% (minimum 75%, Missing); salivary gland: 56.3830% (minimum 70%, Missing); skeletal muscle: 57.6087% (minimum 75%, Missing); skin: 60.2273% (minimum 65%, Missing); small intestine: 59.1078% (minimum 75%, Missing); smooth muscle: 60.2273% (minimum 75%, Missing); spinal cord: 71.9457% (minimum 75%, Missing); spleen: 61.8677% (minimum 65%, Missing); stomach: 57.4007% (minimum 70%, Missing); thymus: 51.7915% (minimum 65%, Missing); thyroid gland: 61.1538% (minimum 65%, Missing); tongue: 53.3557% (minimum 70%, Missing); urinary bladder: 56.5836% (minimum 70%, Missing)",-0.179586,-0.166443,-0.461434,0,8,partial,39.2,13.9,17.9,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (manageable, limit 5); liver: 17.4 nTPM (vital, limit 1); thymus: 14.8 nTPM (manageable, limit 5); tongue: 13.9 nTPM (protected, limit 2); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 2); colon: 12.7 nTPM (protected, limit 2); salivary gland: 12.3 nTPM (protected, limit 2); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); stomach: 11.8 nTPM (protected, limit 2); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 2); smooth muscle: 10.5 nTPM (vital, limit 1); skin: 10.5 nTPM (manageable, limit 5); thyroid gland: 10.1 nTPM (manageable, limit 5); spleen: 9.8 nTPM (manageable, limit 5); pancreas: 9.7 nTPM (vital, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000076053,RBM7,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0414% (minimum 65%, Missing); adrenal gland: 64.3725% (minimum 75%, Missing); basal ganglia: 73.6111% (minimum 75%, Missing); bone marrow: 28.8566% (minimum 75%, Missing); cerebellum: 74.6479% (minimum 75%, Missing); colon: 55.5944% (minimum 70%, Missing); duodenum: 72.6027% (minimum 75%, Missing); esophagus: 55.0173% (minimum 70%, Missing); heart muscle: 62.3529% (minimum 75%, Missing); kidney: 56.3830% (minimum 75%, Missing); liver: 47.7477% (minimum 75%, Missing); lung: 54.4521% (minimum 75%, Missing); pancreas: 62.1094% (minimum 65%, Supported); parathyroid gland: 63.3466% (minimum 70%, Missing); pituitary gland: 69.4323% (minimum 75%, Missing); rectum: 59.5506% (minimum 70%, Missing); retina: 70.6667% (minimum 75%, Missing); salivary gland: 56.3830% (minimum 70%, Missing); skeletal muscle: 57.6087% (minimum 75%, Missing); skin: 60.2273% (minimum 65%, Missing); small intestine: 59.1078% (minimum 75%, Missing); smooth muscle: 60.2273% (minimum 75%, Missing); spinal cord: 71.9457% (minimum 75%, Missing); spleen: 61.8677% (minimum 65%, Missing); stomach: 57.4007% (minimum 70%, Missing); thymus: 51.7915% (minimum 65%, Missing); thyroid gland: 61.1538% (minimum 65%, Missing); tongue: 53.3557% (minimum 70%, Missing); urinary bladder: 56.5836% (minimum 70%, Missing)",-0.179586,-0.166443,-0.461434,0,8,partial,39.2,13.9,17.9,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (manageable, limit 5); liver: 17.4 nTPM (vital, limit 1); thymus: 14.8 nTPM (manageable, limit 5); tongue: 13.9 nTPM (protected, limit 3); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 3); colon: 12.7 nTPM (protected, limit 3); salivary gland: 12.3 nTPM (protected, limit 3); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); stomach: 11.8 nTPM (protected, limit 3); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 3); smooth muscle: 10.5 nTPM (vital, limit 1); skin: 10.5 nTPM (manageable, limit 5); thyroid gland: 10.1 nTPM (manageable, limit 5); spleen: 9.8 nTPM (manageable, limit 5); pancreas: 9.7 nTPM (vital, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000076053,RBM7,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0414% (minimum 65%, Missing); adrenal gland: 64.3725% (minimum 75%, Missing); basal ganglia: 73.6111% (minimum 75%, Missing); bone marrow: 28.8566% (minimum 75%, Missing); cerebellum: 74.6479% (minimum 75%, Missing); colon: 55.5944% (minimum 70%, Missing); duodenum: 72.6027% (minimum 75%, Missing); esophagus: 55.0173% (minimum 70%, Missing); heart muscle: 62.3529% (minimum 75%, Missing); kidney: 56.3830% (minimum 75%, Missing); liver: 47.7477% (minimum 75%, Missing); lung: 54.4521% (minimum 75%, Missing); pancreas: 62.1094% (minimum 65%, Supported); parathyroid gland: 63.3466% (minimum 70%, Missing); pituitary gland: 69.4323% (minimum 75%, Missing); rectum: 59.5506% (minimum 70%, Missing); retina: 70.6667% (minimum 75%, Missing); salivary gland: 56.3830% (minimum 70%, Missing); skeletal muscle: 57.6087% (minimum 75%, Missing); skin: 60.2273% (minimum 65%, Missing); small intestine: 59.1078% (minimum 75%, Missing); smooth muscle: 60.2273% (minimum 75%, Missing); spinal cord: 71.9457% (minimum 75%, Missing); spleen: 61.8677% (minimum 65%, Missing); stomach: 57.4007% (minimum 70%, Missing); thymus: 51.7915% (minimum 65%, Missing); thyroid gland: 61.1538% (minimum 65%, Missing); tongue: 53.3557% (minimum 70%, Missing); urinary bladder: 56.5836% (minimum 70%, Missing)",-0.179586,-0.166443,-0.461434,0,8,partial,39.2,13.9,17.9,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (manageable, limit 5); liver: 17.4 nTPM (vital, limit 1); thymus: 14.8 nTPM (manageable, limit 5); tongue: 13.9 nTPM (protected, limit 3); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 3); colon: 12.7 nTPM (protected, limit 3); salivary gland: 12.3 nTPM (protected, limit 3); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); stomach: 11.8 nTPM (protected, limit 3); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 3); smooth muscle: 10.5 nTPM (vital, limit 1); skin: 10.5 nTPM (manageable, limit 5); thyroid gland: 10.1 nTPM (manageable, limit 5); spleen: 9.8 nTPM (manageable, limit 5); pancreas: 9.7 nTPM (vital, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000076053,RBM7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0414% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 64.3725% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.6111% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 28.8566% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.6479% (minimum 75%, Baseline (adaptation disabled)); colon: 55.5944% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.6027% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.0173% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 62.3529% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.3830% (minimum 75%, Baseline (adaptation disabled)); liver: 47.7477% (minimum 75%, Baseline (adaptation disabled)); lung: 54.4521% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.1094% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.3466% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.4323% (minimum 75%, Baseline (adaptation disabled)); rectum: 59.5506% (minimum 70%, Baseline (adaptation disabled)); retina: 70.6667% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.3830% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 57.6087% (minimum 75%, Baseline (adaptation disabled)); skin: 60.2273% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.1078% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.2273% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.9457% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.8677% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.4007% (minimum 70%, Baseline (adaptation disabled)); thymus: 51.7915% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 61.1538% (minimum 65%, Baseline (adaptation disabled)); tongue: 53.3557% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.5836% (minimum 70%, Baseline (adaptation disabled))",-0.179586,-0.166443,-0.461434,0,8,partial,39.2,13.9,17.9,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (manageable, limit 5); liver: 17.4 nTPM (vital, limit 1); thymus: 14.8 nTPM (manageable, limit 5); tongue: 13.9 nTPM (protected, limit 3); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 3); colon: 12.7 nTPM (protected, limit 3); salivary gland: 12.3 nTPM (protected, limit 3); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); stomach: 11.8 nTPM (protected, limit 3); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 3); smooth muscle: 10.5 nTPM (vital, limit 1); skin: 10.5 nTPM (manageable, limit 5); thyroid gland: 10.1 nTPM (manageable, limit 5); spleen: 9.8 nTPM (manageable, limit 5); pancreas: 9.7 nTPM (vital, limit 1); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000076053,RBM7,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 94.8835% (minimum 99%, Missing); pancreas: 96.6496% (minimum 99%, Missing); rectum: 96.1574% (minimum 97%, Missing); salivary gland: 93.8121% (minimum 97%, Missing); skeletal muscle: 98.6230% (minimum 99%, Missing); smooth muscle: 96.3358% (minimum 99%, Missing); stomach: 94.2805% (minimum 97%, Missing); tongue: 96.0240% (minimum 97%, Missing)",0.0404626,-0.031879,-0.0411649,0,80,unavailable,11.2,13.7,2,"salivary gland: 13.7 nTPM (protected, limit 2); stomach: 12.6 nTPM (protected, limit 2); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 2); rectum: 8.3 nTPM (protected, limit 2); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077274,CAPN6,admission_only,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340463,0.238121,0.198835,0,80,unavailable,11.2,13.7,2,"salivary gland: 13.7 nTPM (protected, limit 2); stomach: 12.6 nTPM (protected, limit 2); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 2); rectum: 8.3 nTPM (protected, limit 2); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077274,CAPN6,selectivity_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340463,0.238121,0.198835,0,80,unavailable,11.2,13.7,2,"salivary gland: 13.7 nTPM (protected, limit 3); stomach: 12.6 nTPM (protected, limit 3); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); rectum: 8.3 nTPM (protected, limit 3); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077274,CAPN6,grid_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340463,0.238121,0.198835,0,80,unavailable,11.2,13.7,2,"salivary gland: 13.7 nTPM (protected, limit 3); stomach: 12.6 nTPM (protected, limit 3); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); rectum: 8.3 nTPM (protected, limit 3); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077274,CAPN6,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340463,0.238121,0.198835,0,80,unavailable,11.2,13.7,2,"salivary gland: 13.7 nTPM (protected, limit 3); stomach: 12.6 nTPM (protected, limit 3); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); rectum: 8.3 nTPM (protected, limit 3); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077274,CAPN6,current_fixed,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.5000% (minimum 95%, Enhanced); amygdala: 42.4242% (minimum 99%, Missing); basal ganglia: 43.7500% (minimum 99%, Missing); cerebellum: 93.3333% (minimum 95%, Enhanced); cerebral cortex: 18.9189% (minimum 99%, Missing); choroid plexus: 93.3333% (minimum 99%, Missing); hippocampal formation: 56.0000% (minimum 99%, Missing); hypothalamus: 42.4242% (minimum 99%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 93.3333% (minimum 95%, Enhanced); pituitary gland: 82.3529% (minimum 99%, Missing); retina: 40.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 80%, Enhanced); spinal cord: 56.0000% (minimum 99%, Missing); stomach: 87.5000% (minimum 97%, Missing); tongue: 93.3333% (minimum 97%, Missing)",0.05,-0.133333,-0.800811,0,2,partial,6,0.7,0.1,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077279,DCX,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.4242% (minimum 75%, Missing); basal ganglia: 43.7500% (minimum 75%, Missing); cerebral cortex: 18.9189% (minimum 75%, Missing); hippocampal formation: 56.0000% (minimum 75%, Missing); hypothalamus: 42.4242% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); retina: 40.0000% (minimum 75%, Missing); spinal cord: 56.0000% (minimum 75%, Missing)",0.35,0.116667,-0.560811,0,2,partial,6,0.7,0.1,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077279,DCX,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.4242% (minimum 75%, Missing); basal ganglia: 43.7500% (minimum 75%, Missing); cerebral cortex: 18.9189% (minimum 75%, Missing); hippocampal formation: 56.0000% (minimum 75%, Missing); hypothalamus: 42.4242% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); retina: 40.0000% (minimum 75%, Missing); spinal cord: 56.0000% (minimum 75%, Missing)",0.35,0.116667,-0.560811,0,2,partial,6,0.7,0.1,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077279,DCX,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.4242% (minimum 75%, Missing); basal ganglia: 43.7500% (minimum 75%, Missing); cerebral cortex: 18.9189% (minimum 75%, Missing); hippocampal formation: 56.0000% (minimum 75%, Missing); hypothalamus: 42.4242% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); retina: 40.0000% (minimum 75%, Missing); spinal cord: 56.0000% (minimum 75%, Missing)",0.35,0.116667,-0.560811,0,2,partial,6,0.7,0.1,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077279,DCX,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.4242% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 43.7500% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 18.9189% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 56.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 42.4242% (minimum 75%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 40.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); spinal cord: 56.0000% (minimum 75%, Baseline (adaptation disabled))",0.283333,-0.0333333,-0.560811,0,2,partial,6,0.7,0.1,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077279,DCX,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2138% (minimum 99%, Missing); basal ganglia: 92.2091% (minimum 99%, Missing); choroid plexus: 49.1329% (minimum 99%, Missing); hippocampal formation: 92.0276% (minimum 99%, Missing); hypothalamus: 90.5131% (minimum 99%, Missing); lung: 93.2203% (minimum 99%, Missing); midbrain: 98.7328% (minimum 99%, Missing); pituitary gland: 86.8152% (minimum 99%, Missing); retina: 94.3491% (minimum 99%, Missing); spinal cord: 97.4974% (minimum 99%, Missing)",0.0457401,0.03,-0.498671,0,8,partial,96.8,1.7,0.4,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077327,SPAG6,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 49.1329% (minimum 75%, Missing)",0.34574,0.3,-0.258671,0,8,partial,96.8,1.7,0.4,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077327,SPAG6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 49.1329% (minimum 75%, Missing)",0.34574,0.3,-0.258671,0,8,partial,96.8,1.7,0.4,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077327,SPAG6,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 49.1329% (minimum 75%, Missing)",0.34574,0.3,-0.258671,0,8,partial,96.8,1.7,0.4,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077327,SPAG6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 49.1329% (minimum 75%, Baseline (adaptation disabled))",0.34574,0.282143,-0.258671,0,8,partial,96.8,1.7,0.4,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077327,SPAG6,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.4386% (minimum 90%, Approved); adrenal gland: 77.8281% (minimum 98%, Approved); amygdala: 91.4894% (minimum 99%, Missing); basal ganglia: 91.4894% (minimum 99%, Missing); bone marrow: 30.6050% (minimum 98%, Approved); cerebellum: 82.2967% (minimum 98%, Approved); cerebral cortex: 82.6923% (minimum 98%, Approved); choroid plexus: 93.4783% (minimum 99%, Missing); colon: 78.5388% (minimum 95%, Approved); duodenum: 65.9004% (minimum 98%, Approved); esophagus: 81.5166% (minimum 95%, Approved); heart muscle: 81.9048% (minimum 98%, Approved); hippocampal formation: 90.0524% (minimum 99%, Missing); hypothalamus: 91.0053% (minimum 99%, Missing); kidney: 85.1485% (minimum 98%, Approved); liver: 68.2540% (minimum 98%, Approved); lung: 77.8281% (minimum 98%, Approved); lymph node: 50.7375% (minimum 97%, Missing); midbrain: 91.4894% (minimum 99%, Missing); pancreas: 74.4589% (minimum 98%, Approved); parathyroid gland: 82.6923% (minimum 95%, Approved); pituitary gland: 88.2051% (minimum 99%, Missing); rectum: 77.8281% (minimum 95%, Approved); retina: 76.7857% (minimum 99%, Missing); salivary gland: 79.2627% (minimum 95%, Approved); skeletal muscle: 81.9048% (minimum 98%, Approved); skin: 75.4386% (minimum 90%, Approved); small intestine: 73.5043% (minimum 98%, Approved); smooth muscle: 80.0000% (minimum 98%, Approved); spinal cord: 86.8687% (minimum 99%, Missing); spleen: 67.7165% (minimum 90%, Approved); stomach: 74.7826% (minimum 95%, Approved); thymus: 55.4839% (minimum 95%, Missing); thyroid gland: 76.4444% (minimum 90%, Approved); tongue: 82.6923% (minimum 97%, Missing); urinary bladder: 78.5388% (minimum 95%, Approved)",-0.395161,-0.462625,-0.67395,0,0,routine_complete,39,16.7,13.8,"bone marrow: 39 nTPM (vital, limit 2); lymph node: 16.7 nTPM (protected, limit 2); thymus: 13.8 nTPM (manageable, limit 5); duodenum: 8.9 nTPM (vital, limit 2); liver: 8 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 2); pancreas: 5.9 nTPM (vital, limit 2); stomach: 5.8 nTPM (protected, limit 4); retina: 5.2 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 4); lung: 4.9 nTPM (vital, limit 2); adrenal gland: 4.9 nTPM (vital, limit 2); urinary bladder: 4.7 nTPM (protected, limit 4); colon: 4.7 nTPM (protected, limit 4); salivary gland: 4.5 nTPM (protected, limit 4); smooth muscle: 4.3 nTPM (vital, limit 2); heart muscle: 3.8 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); cerebellum: 3.7 nTPM (vital, limit 2); cerebral cortex: 3.6 nTPM (vital, limit 2); tongue: 3.6 nTPM (protected, limit 2); kidney: 3 nTPM (vital, limit 2); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077458,FAM76B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 30.6050% (minimum 70%, Approved); duodenum: 65.9004% (minimum 70%, Approved); liver: 68.2540% (minimum 70%, Approved); lymph node: 50.7375% (minimum 70%, Missing); thymus: 55.4839% (minimum 65%, Missing)",-0.0951613,-0.192625,-0.39395,0,0,routine_complete,39,16.7,13.8,"bone marrow: 39 nTPM (vital, limit 2); lymph node: 16.7 nTPM (protected, limit 2); thymus: 13.8 nTPM (manageable, limit 5); duodenum: 8.9 nTPM (vital, limit 2); liver: 8 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 2); pancreas: 5.9 nTPM (vital, limit 2); stomach: 5.8 nTPM (protected, limit 4); retina: 5.2 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 4); lung: 4.9 nTPM (vital, limit 2); adrenal gland: 4.9 nTPM (vital, limit 2); urinary bladder: 4.7 nTPM (protected, limit 4); colon: 4.7 nTPM (protected, limit 4); salivary gland: 4.5 nTPM (protected, limit 4); smooth muscle: 4.3 nTPM (vital, limit 2); heart muscle: 3.8 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); cerebellum: 3.7 nTPM (vital, limit 2); cerebral cortex: 3.6 nTPM (vital, limit 2); tongue: 3.6 nTPM (protected, limit 2); kidney: 3 nTPM (vital, limit 2); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077458,FAM76B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 30.6050% (minimum 70%, Approved); duodenum: 65.9004% (minimum 70%, Approved); liver: 68.2540% (minimum 70%, Approved); lymph node: 50.7375% (minimum 70%, Missing); thymus: 55.4839% (minimum 65%, Missing)",-0.0951613,-0.192625,-0.39395,0,0,routine_complete,39,16.7,13.8,"bone marrow: 39 nTPM (vital, limit 2); lymph node: 16.7 nTPM (protected, limit 3); thymus: 13.8 nTPM (manageable, limit 5); duodenum: 8.9 nTPM (vital, limit 2); liver: 8 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 2); pancreas: 5.9 nTPM (vital, limit 2); stomach: 5.8 nTPM (protected, limit 4); retina: 5.2 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 4); lung: 4.9 nTPM (vital, limit 2); adrenal gland: 4.9 nTPM (vital, limit 2); urinary bladder: 4.7 nTPM (protected, limit 4); colon: 4.7 nTPM (protected, limit 4); salivary gland: 4.5 nTPM (protected, limit 4); smooth muscle: 4.3 nTPM (vital, limit 2); heart muscle: 3.8 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); cerebellum: 3.7 nTPM (vital, limit 2); cerebral cortex: 3.6 nTPM (vital, limit 2); tongue: 3.6 nTPM (protected, limit 3); kidney: 3 nTPM (vital, limit 2); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077458,FAM76B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 30.6050% (minimum 70%, Approved); duodenum: 65.9004% (minimum 70%, Approved); liver: 68.2540% (minimum 70%, Approved); lymph node: 50.7375% (minimum 70%, Missing); thymus: 55.4839% (minimum 65%, Missing)",-0.0951613,-0.192625,-0.39395,0,0,routine_complete,39,16.7,13.8,"bone marrow: 39 nTPM (vital, limit 2); lymph node: 16.7 nTPM (protected, limit 3); thymus: 13.8 nTPM (manageable, limit 5); duodenum: 8.9 nTPM (vital, limit 2); liver: 8 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 2); pancreas: 5.9 nTPM (vital, limit 2); stomach: 5.8 nTPM (protected, limit 4); retina: 5.2 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 4); lung: 4.9 nTPM (vital, limit 2); adrenal gland: 4.9 nTPM (vital, limit 2); urinary bladder: 4.7 nTPM (protected, limit 4); colon: 4.7 nTPM (protected, limit 4); salivary gland: 4.5 nTPM (protected, limit 4); smooth muscle: 4.3 nTPM (vital, limit 2); heart muscle: 3.8 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); cerebellum: 3.7 nTPM (vital, limit 2); cerebral cortex: 3.6 nTPM (vital, limit 2); tongue: 3.6 nTPM (protected, limit 3); kidney: 3 nTPM (vital, limit 2); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077458,FAM76B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 30.6050% (minimum 75%, Baseline (adaptation disabled)); duodenum: 65.9004% (minimum 75%, Baseline (adaptation disabled)); liver: 68.2540% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.7375% (minimum 70%, Baseline (adaptation disabled)); pancreas: 74.4589% (minimum 75%, Baseline (adaptation disabled)); small intestine: 73.5043% (minimum 75%, Baseline (adaptation disabled)); thymus: 55.4839% (minimum 65%, Baseline (adaptation disabled))",-0.0951613,-0.192625,-0.44395,0,0,routine_complete,39,16.7,13.8,"bone marrow: 39 nTPM (vital, limit 1); lymph node: 16.7 nTPM (protected, limit 3); thymus: 13.8 nTPM (manageable, limit 5); duodenum: 8.9 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); liver: 8 nTPM (vital, limit 1); small intestine: 6.2 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 3); adipose tissue: 5.6 nTPM (manageable, limit 5); skin: 5.6 nTPM (manageable, limit 5); thyroid gland: 5.3 nTPM (manageable, limit 5); retina: 5.2 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 3); adrenal gland: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); colon: 4.7 nTPM (protected, limit 3); salivary gland: 4.5 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); heart muscle: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.6 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077458,FAM76B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.0464974,0.03,0.00824561,0,2,partial,0.2,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077800,FKBP6,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346497,0.3,0.248246,0,2,partial,0.2,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077800,FKBP6,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346497,0.3,0.248246,0,2,partial,0.2,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077800,FKBP6,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346497,0.3,0.248246,0,2,partial,0.2,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077800,FKBP6,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346497,0.296497,0.246497,0,2,partial,0.2,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077800,FKBP6,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0466997,0.0234211,0.01,0,8,partial,0.3,0.2,0.1,,,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077935,SMC1B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.3467,0.293421,0.25,0,8,partial,0.3,0.2,0.1,,,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077935,SMC1B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.3467,0.293421,0.25,0,8,partial,0.3,0.2,0.1,,,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077935,SMC1B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.3467,0.293421,0.25,0,8,partial,0.3,0.2,0.1,,,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077935,SMC1B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.3467,0.293421,0.240164,0,8,partial,0.3,0.2,0.1,,,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000077935,SMC1B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 92.6241% (minimum 99%, Missing); amygdala: 91.3287% (minimum 99%, Missing); basal ganglia: 90.4432% (minimum 99%, Missing); bone marrow: 89.9449% (minimum 95%, Enhanced); cerebellum: 82.5537% (minimum 95%, Enhanced); cerebral cortex: 89.0859% (minimum 99%, Missing); choroid plexus: 92.8876% (minimum 99%, Missing); esophagus: 94.7750% (minimum 97%, Missing); heart muscle: 90.8206% (minimum 99%, Missing); hippocampal formation: 91.4566% (minimum 99%, Missing); hypothalamus: 90.8206% (minimum 99%, Missing); kidney: 91.3287% (minimum 99%, Missing); liver: 91.8425% (minimum 95%, Enhanced); lung: 93.9568% (minimum 99%, Missing); lymph node: 91.5849% (minimum 97%, Missing); midbrain: 91.5849% (minimum 99%, Missing); pancreas: 94.0922% (minimum 99%, Missing); parathyroid gland: 85.1369% (minimum 97%, Missing); pituitary gland: 92.2316% (minimum 99%, Missing); retina: 86.1478% (minimum 99%, Missing); salivary gland: 92.4929% (minimum 97%, Missing); skeletal muscle: 80.7169% (minimum 99%, Missing); skin: 89.8212% (minimum 95%, Missing); small intestine: 94.0922% (minimum 95%, Enhanced); smooth muscle: 93.5530% (minimum 99%, Missing); spinal cord: 92.8876% (minimum 99%, Missing); thymus: 93.5530% (minimum 95%, Missing); thyroid gland: 89.0859% (minimum 95%, Missing); tongue: 86.9507% (minimum 97%, Missing); urinary bladder: 94.2280% (minimum 97%, Missing)",-0.0591405,-0.118631,-0.182831,0,4,partial,15.6,11.4,8,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 6); parathyroid gland: 11.4 nTPM (protected, limit 2); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 2); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); skin: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 6); basal ganglia: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); pituitary gland: 5.5 nTPM (vital, limit 1); salivary gland: 5.3 nTPM (protected, limit 2); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078043,PIAS2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.240859,0.151369,0.0571693,0,4,partial,15.6,11.4,8,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 6); parathyroid gland: 11.4 nTPM (protected, limit 2); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 2); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); skin: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 6); basal ganglia: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); pituitary gland: 5.5 nTPM (vital, limit 1); salivary gland: 5.3 nTPM (protected, limit 2); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078043,PIAS2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.240859,0.151369,0.0571693,0,4,partial,15.6,11.4,8,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 6); parathyroid gland: 11.4 nTPM (protected, limit 3); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 3); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); skin: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 6); basal ganglia: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); pituitary gland: 5.5 nTPM (vital, limit 1); salivary gland: 5.3 nTPM (protected, limit 3); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078043,PIAS2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.240859,0.151369,0.0571693,0,4,partial,15.6,11.4,8,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 6); parathyroid gland: 11.4 nTPM (protected, limit 3); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 3); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); skin: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 6); basal ganglia: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); pituitary gland: 5.5 nTPM (vital, limit 1); salivary gland: 5.3 nTPM (protected, limit 3); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078043,PIAS2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.240859,0.151369,0.0571693,0,4,partial,15.6,11.4,8,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 1); parathyroid gland: 11.4 nTPM (protected, limit 3); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 3); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); skin: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 3); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); midbrain: 6 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); pituitary gland: 5.5 nTPM (vital, limit 1); salivary gland: 5.3 nTPM (protected, limit 3); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078043,PIAS2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 84.4595% (minimum 90%, Approved); adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 23.4962% (minimum 99%, Missing); basal ganglia: 22.8938% (minimum 99%, Missing); cerebellum: 22.6449% (minimum 98%, Approved); cerebral cortex: 24.1779% (minimum 98%, Approved); choroid plexus: 91.2409% (minimum 99%, Missing); colon: 90.5797% (minimum 97%, Missing); esophagus: 44.4840% (minimum 95%, Approved); heart muscle: 3.9872% (minimum 99%, Missing); hippocampal formation: 28.2805% (minimum 99%, Missing); hypothalamus: 26.7094% (minimum 99%, Missing); kidney: 49.6032% (minimum 99%, Missing); liver: 91.2409% (minimum 99%, Missing); lung: 44.3262% (minimum 99%, Missing); midbrain: 25.3550% (minimum 99%, Missing); pancreas: 64.7668% (minimum 99%, Missing); parathyroid gland: 91.2409% (minimum 97%, Missing); pituitary gland: 36.7647% (minimum 99%, Missing); rectum: 93.2836% (minimum 97%, Missing); retina: 83.3333% (minimum 99%, Missing); salivary gland: 41.6667% (minimum 95%, Approved); skeletal muscle: 95.4198% (minimum 98%, Approved); skin: 46.4684% (minimum 90%, Approved); small intestine: 90.5797% (minimum 99%, Missing); smooth muscle: 96.8992% (minimum 98%, Approved); spinal cord: 33.8753% (minimum 99%, Missing); stomach: 80.1282% (minimum 97%, Missing); thyroid gland: 37.5375% (minimum 95%, Missing); tongue: 96.8992% (minimum 97%, Missing); urinary bladder: 86.2069% (minimum 97%, Missing)",-0.574625,-0.533333,-0.950128,0,1,partial,301,17.5,20.8,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 2); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 2); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (manageable, limit 5); salivary gland: 17.5 nTPM (protected, limit 4); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 4); skin: 14.4 nTPM (manageable, limit 10); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078114,NEBL,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 23.4962% (minimum 75%, Missing); basal ganglia: 22.8938% (minimum 75%, Missing); cerebellum: 22.6449% (minimum 70%, Approved); cerebral cortex: 24.1779% (minimum 70%, Approved); esophagus: 44.4840% (minimum 65%, Approved); heart muscle: 3.9872% (minimum 75%, Missing); hippocampal formation: 28.2805% (minimum 75%, Missing); hypothalamus: 26.7094% (minimum 75%, Missing); kidney: 49.6032% (minimum 75%, Missing); lung: 44.3262% (minimum 75%, Missing); midbrain: 25.3550% (minimum 75%, Missing); pancreas: 64.7668% (minimum 75%, Missing); pituitary gland: 36.7647% (minimum 75%, Missing); salivary gland: 41.6667% (minimum 65%, Approved); skin: 46.4684% (minimum 60%, Approved); spinal cord: 33.8753% (minimum 75%, Missing); thyroid gland: 37.5375% (minimum 65%, Missing)",-0.274625,-0.233333,-0.710128,0,1,partial,301,17.5,20.8,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 2); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 2); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (manageable, limit 5); salivary gland: 17.5 nTPM (protected, limit 4); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 4); skin: 14.4 nTPM (manageable, limit 10); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078114,NEBL,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 23.4962% (minimum 75%, Missing); basal ganglia: 22.8938% (minimum 75%, Missing); cerebellum: 22.6449% (minimum 70%, Approved); cerebral cortex: 24.1779% (minimum 70%, Approved); esophagus: 44.4840% (minimum 65%, Approved); heart muscle: 3.9872% (minimum 75%, Missing); hippocampal formation: 28.2805% (minimum 75%, Missing); hypothalamus: 26.7094% (minimum 75%, Missing); kidney: 49.6032% (minimum 75%, Missing); lung: 44.3262% (minimum 75%, Missing); midbrain: 25.3550% (minimum 75%, Missing); pancreas: 64.7668% (minimum 75%, Missing); pituitary gland: 36.7647% (minimum 75%, Missing); salivary gland: 41.6667% (minimum 65%, Approved); skin: 46.4684% (minimum 60%, Approved); spinal cord: 33.8753% (minimum 75%, Missing); thyroid gland: 37.5375% (minimum 65%, Missing)",-0.274625,-0.233333,-0.710128,0,1,partial,301,17.5,20.8,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 2); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 2); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (manageable, limit 5); salivary gland: 17.5 nTPM (protected, limit 4); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 4); skin: 14.4 nTPM (manageable, limit 10); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); adrenal gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078114,NEBL,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 23.4962% (minimum 75%, Missing); basal ganglia: 22.8938% (minimum 75%, Missing); cerebellum: 22.6449% (minimum 70%, Approved); cerebral cortex: 24.1779% (minimum 70%, Approved); esophagus: 44.4840% (minimum 65%, Approved); heart muscle: 3.9872% (minimum 75%, Missing); hippocampal formation: 28.2805% (minimum 75%, Missing); hypothalamus: 26.7094% (minimum 75%, Missing); kidney: 49.6032% (minimum 75%, Missing); lung: 44.3262% (minimum 75%, Missing); midbrain: 25.3550% (minimum 75%, Missing); pancreas: 64.7668% (minimum 75%, Missing); pituitary gland: 36.7647% (minimum 75%, Missing); salivary gland: 41.6667% (minimum 65%, Approved); skin: 46.4684% (minimum 60%, Approved); spinal cord: 33.8753% (minimum 75%, Missing); thyroid gland: 37.5375% (minimum 65%, Missing)",-0.274625,-0.233333,-0.710128,0,1,partial,301,17.5,20.8,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 2); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 2); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (manageable, limit 5); salivary gland: 17.5 nTPM (protected, limit 4); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 4); skin: 14.4 nTPM (manageable, limit 10); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); adrenal gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078114,NEBL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 23.4962% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 22.8938% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 22.6449% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 24.1779% (minimum 75%, Baseline (adaptation disabled)); esophagus: 44.4840% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 3.9872% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 28.2805% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 26.7094% (minimum 75%, Baseline (adaptation disabled)); kidney: 49.6032% (minimum 75%, Baseline (adaptation disabled)); lung: 44.3262% (minimum 75%, Baseline (adaptation disabled)); midbrain: 25.3550% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.7668% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 36.7647% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 41.6667% (minimum 70%, Baseline (adaptation disabled)); skin: 46.4684% (minimum 65%, Baseline (adaptation disabled)); spinal cord: 33.8753% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 37.5375% (minimum 65%, Baseline (adaptation disabled))",-0.274625,-0.283333,-0.710128,0,1,partial,301,17.5,20.8,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 1); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 1); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (manageable, limit 5); salivary gland: 17.5 nTPM (protected, limit 3); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 3); skin: 14.4 nTPM (manageable, limit 5); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); adrenal gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078114,NEBL,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 79.0698% (minimum 95%, Missing); adrenal gland: 82.9268% (minimum 99%, Missing); amygdala: 89.4737% (minimum 99%, Missing); basal ganglia: 87.1795% (minimum 99%, Missing); bone marrow: 45.9459% (minimum 99%, Missing); cerebellum: 89.4737% (minimum 99%, Missing); cerebral cortex: 80.9524% (minimum 99%, Missing); choroid plexus: 85.0000% (minimum 99%, Missing); colon: 62.9630% (minimum 97%, Missing); duodenum: 61.8182% (minimum 99%, Missing); esophagus: 68.0000% (minimum 97%, Missing); heart muscle: 75.5556% (minimum 99%, Missing); hippocampal formation: 91.8919% (minimum 99%, Missing); hypothalamus: 80.9524% (minimum 99%, Missing); kidney: 70.8333% (minimum 99%, Missing); liver: 38.6364% (minimum 99%, Missing); lung: 68.0000% (minimum 99%, Missing); lymph node: 49.2754% (minimum 97%, Missing); midbrain: 91.8919% (minimum 99%, Missing); pancreas: 45.9459% (minimum 99%, Missing); parathyroid gland: 72.3404% (minimum 97%, Missing); pituitary gland: 73.9130% (minimum 99%, Missing); rectum: 61.8182% (minimum 97%, Missing); retina: 62.9630% (minimum 99%, Missing); salivary gland: 51.5152% (minimum 97%, Missing); skeletal muscle: 82.9268% (minimum 99%, Missing); skin: 65.3846% (minimum 95%, Missing); small intestine: 62.9630% (minimum 99%, Missing); smooth muscle: 82.9268% (minimum 99%, Missing); spinal cord: 89.4737% (minimum 99%, Missing); spleen: 65.3846% (minimum 95%, Missing); stomach: 65.3846% (minimum 97%, Missing); thymus: 23.6111% (minimum 95%, Missing); thyroid gland: 51.5152% (minimum 95%, Missing); tongue: 79.0698% (minimum 97%, Missing); urinary bladder: 64.1509% (minimum 97%, Missing)",-0.713889,-0.477246,-0.603636,0,3,partial,5.4,3.5,11,"thymus: 11 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); duodenum: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078177,N4BP2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 45.9459% (minimum 75%, Missing); colon: 62.9630% (minimum 70%, Missing); duodenum: 61.8182% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); kidney: 70.8333% (minimum 75%, Missing); liver: 38.6364% (minimum 75%, Missing); lung: 68.0000% (minimum 75%, Missing); lymph node: 49.2754% (minimum 70%, Missing); pancreas: 45.9459% (minimum 75%, Missing); pituitary gland: 73.9130% (minimum 75%, Missing); rectum: 61.8182% (minimum 70%, Missing); retina: 62.9630% (minimum 75%, Missing); salivary gland: 51.5152% (minimum 70%, Missing); small intestine: 62.9630% (minimum 75%, Missing); stomach: 65.3846% (minimum 70%, Missing); thymus: 23.6111% (minimum 65%, Missing); thyroid gland: 51.5152% (minimum 65%, Missing); urinary bladder: 64.1509% (minimum 70%, Missing)",-0.413889,-0.207246,-0.363636,0,3,partial,5.4,3.5,11,"thymus: 11 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); duodenum: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078177,N4BP2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 45.9459% (minimum 75%, Missing); colon: 62.9630% (minimum 70%, Missing); duodenum: 61.8182% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); kidney: 70.8333% (minimum 75%, Missing); liver: 38.6364% (minimum 75%, Missing); lung: 68.0000% (minimum 75%, Missing); lymph node: 49.2754% (minimum 70%, Missing); pancreas: 45.9459% (minimum 75%, Missing); pituitary gland: 73.9130% (minimum 75%, Missing); rectum: 61.8182% (minimum 70%, Missing); retina: 62.9630% (minimum 75%, Missing); salivary gland: 51.5152% (minimum 70%, Missing); small intestine: 62.9630% (minimum 75%, Missing); stomach: 65.3846% (minimum 70%, Missing); thymus: 23.6111% (minimum 65%, Missing); thyroid gland: 51.5152% (minimum 65%, Missing); urinary bladder: 64.1509% (minimum 70%, Missing)",-0.413889,-0.207246,-0.363636,0,3,partial,5.4,3.5,11,"thymus: 11 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); duodenum: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078177,N4BP2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 45.9459% (minimum 75%, Missing); colon: 62.9630% (minimum 70%, Missing); duodenum: 61.8182% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); kidney: 70.8333% (minimum 75%, Missing); liver: 38.6364% (minimum 75%, Missing); lung: 68.0000% (minimum 75%, Missing); lymph node: 49.2754% (minimum 70%, Missing); pancreas: 45.9459% (minimum 75%, Missing); pituitary gland: 73.9130% (minimum 75%, Missing); rectum: 61.8182% (minimum 70%, Missing); retina: 62.9630% (minimum 75%, Missing); salivary gland: 51.5152% (minimum 70%, Missing); small intestine: 62.9630% (minimum 75%, Missing); stomach: 65.3846% (minimum 70%, Missing); thymus: 23.6111% (minimum 65%, Missing); thyroid gland: 51.5152% (minimum 65%, Missing); urinary bladder: 64.1509% (minimum 70%, Missing)",-0.413889,-0.207246,-0.363636,0,3,partial,5.4,3.5,11,"thymus: 11 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); duodenum: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078177,N4BP2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 45.9459% (minimum 75%, Baseline (adaptation disabled)); colon: 62.9630% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.8182% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.0000% (minimum 70%, Baseline (adaptation disabled)); kidney: 70.8333% (minimum 75%, Baseline (adaptation disabled)); liver: 38.6364% (minimum 75%, Baseline (adaptation disabled)); lung: 68.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.2754% (minimum 70%, Baseline (adaptation disabled)); pancreas: 45.9459% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 73.9130% (minimum 75%, Baseline (adaptation disabled)); rectum: 61.8182% (minimum 70%, Baseline (adaptation disabled)); retina: 62.9630% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.5152% (minimum 70%, Baseline (adaptation disabled)); small intestine: 62.9630% (minimum 75%, Baseline (adaptation disabled)); stomach: 65.3846% (minimum 70%, Baseline (adaptation disabled)); thymus: 23.6111% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 51.5152% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 64.1509% (minimum 70%, Baseline (adaptation disabled))",-0.413889,-0.207246,-0.363636,0,3,partial,5.4,3.5,11,"thymus: 11 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); duodenum: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078177,N4BP2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3937% (minimum 95%, Missing); adrenal gland: 94.2922% (minimum 99%, Missing); amygdala: 92.1875% (minimum 99%, Missing); basal ganglia: 93.0180% (minimum 99%, Missing); bone marrow: 93.6508% (minimum 99%, Missing); cerebellum: 95.3811% (minimum 99%, Missing); cerebral cortex: 92.8090% (minimum 99%, Missing); choroid plexus: 91.1700% (minimum 99%, Missing); colon: 92.6009% (minimum 97%, Missing); duodenum: 97.4057% (minimum 99%, Missing); esophagus: 94.9425% (minimum 97%, Missing); heart muscle: 91.7778% (minimum 99%, Missing); hippocampal formation: 91.9822% (minimum 99%, Missing); hypothalamus: 93.2280% (minimum 99%, Missing); kidney: 92.6009% (minimum 99%, Missing); liver: 87.8723% (minimum 99%, Missing); lung: 94.7248% (minimum 99%, Missing); lymph node: 91.5743% (minimum 97%, Missing); midbrain: 89.9782% (minimum 99%, Missing); pancreas: 94.9425% (minimum 99%, Missing); parathyroid gland: 90.7692% (minimum 97%, Missing); pituitary gland: 95.3811% (minimum 99%, Missing); rectum: 95.8237% (minimum 97%, Missing); retina: 93.0180% (minimum 99%, Missing); salivary gland: 95.3811% (minimum 97%, Missing); skeletal muscle: 91.7778% (minimum 99%, Missing); skin: 90.3720% (minimum 95%, Missing); small intestine: 94.2922% (minimum 99%, Missing); smooth muscle: 94.0774% (minimum 99%, Missing); spinal cord: 88.2479% (minimum 99%, Missing); spleen: 90.7692% (minimum 95%, Missing); stomach: 94.5080% (minimum 97%, Missing); thymus: 94.0774% (minimum 95%, Missing); thyroid gland: 89.7826% (minimum 95%, Missing); tongue: 90.5702% (minimum 97%, Missing); urinary bladder: 91.7778% (minimum 97%, Missing)",-0.0521739,-0.0642982,-0.111277,0,80,unavailable,5.7,4.3,4.7,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 2); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078487,ZCWPW1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.247826,0.205702,0.128723,0,80,unavailable,5.7,4.3,4.7,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 2); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078487,ZCWPW1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.247826,0.205702,0.128723,0,80,unavailable,5.7,4.3,4.7,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 3); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); kidney: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078487,ZCWPW1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.247826,0.205702,0.128723,0,80,unavailable,5.7,4.3,4.7,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 3); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); kidney: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078487,ZCWPW1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.247826,0.205702,0.128723,0,80,unavailable,5.7,4.3,4.7,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 3); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); kidney: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078487,ZCWPW1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 89.7727% (minimum 99%, Missing); amygdala: 97.5309% (minimum 99%, Missing); basal ganglia: 96.3415% (minimum 99%, Missing); bone marrow: 84.9462% (minimum 99%, Missing); cerebellum: 98.7500% (minimum 99%, Missing); cerebral cortex: 94.0476% (minimum 99%, Missing); choroid plexus: 97.5309% (minimum 99%, Missing); duodenum: 96.3415% (minimum 99%, Missing); esophagus: 95.1807% (minimum 97%, Missing); heart muscle: 87.7778% (minimum 99%, Missing); hippocampal formation: 97.5309% (minimum 99%, Missing); hypothalamus: 97.5309% (minimum 99%, Missing); kidney: 98.7500% (minimum 99%, Missing); liver: 98.7500% (minimum 99%, Missing); lung: 98.7500% (minimum 99%, Missing); lymph node: 90.8046% (minimum 97%, Missing); midbrain: 97.5309% (minimum 99%, Missing); pancreas: 89.7727% (minimum 99%, Missing); pituitary gland: 96.3415% (minimum 99%, Missing); retina: 87.7778% (minimum 99%, Missing); salivary gland: 95.1807% (minimum 97%, Missing); skeletal muscle: 78.2178% (minimum 99%, Missing); skin: 94.0476% (minimum 95%, Missing); small intestine: 97.5309% (minimum 99%, Missing); spinal cord: 97.5309% (minimum 99%, Missing); spleen: 91.8605% (minimum 95%, Missing); stomach: 95.1807% (minimum 97%, Missing); thyroid gland: 92.9412% (minimum 95%, Missing); tongue: 91.8605% (minimum 97%, Missing)",-0.0313953,-0.061954,-0.207822,0,3,partial,2.2,0.8,0.7,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078795,PKD2L2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.268605,0.208046,0.0321782,0,3,partial,2.2,0.8,0.7,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078795,PKD2L2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.268605,0.208046,0.0321782,0,3,partial,2.2,0.8,0.7,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078795,PKD2L2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.268605,0.208046,0.0321782,0,3,partial,2.2,0.8,0.7,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078795,PKD2L2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.268605,0.208046,0.0321782,0,3,partial,2.2,0.8,0.7,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000078795,PKD2L2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.0000% (minimum 95%, Enhanced); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 84.3750% (minimum 99%, Missing); bone marrow: 68.0672% (minimum 95%, Enhanced); cerebellum: 77.8846% (minimum 95%, Enhanced); cerebral cortex: 65.3226% (minimum 95%, Enhanced); choroid plexus: 22.5000% (minimum 99%, Missing); duodenum: 94.1860% (minimum 95%, Enhanced); hippocampal formation: 71.6814% (minimum 99%, Missing); hypothalamus: 69.8276% (minimum 99%, Missing); kidney: 61.8321% (minimum 95%, Enhanced); liver: 94.1860% (minimum 95%, Enhanced); lung: 86.1702% (minimum 95%, Enhanced); midbrain: 74.3119% (minimum 99%, Missing); pancreas: 87.0968% (minimum 95%, Enhanced); parathyroid gland: 71.0526% (minimum 80%, Enhanced); pituitary gland: 69.2308% (minimum 99%, Missing); retina: 2.7273% (minimum 99%, Missing); salivary gland: 79.4118% (minimum 80%, Enhanced); small intestine: 86.1702% (minimum 95%, Enhanced); spinal cord: 69.8276% (minimum 99%, Missing); stomach: 73.6364% (minimum 80%, Enhanced); thymus: 82.6531% (minimum 95%, Missing); thyroid gland: 57.8571% (minimum 60%, Enhanced)",-0.123469,-0.0894737,-0.962727,0,2,partial,288.9,3.3,5.9,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000079101,CLUL1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); choroid plexus: 22.5000% (minimum 75%, Missing); hippocampal formation: 71.6814% (minimum 75%, Missing); hypothalamus: 69.8276% (minimum 75%, Missing); midbrain: 74.3119% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); retina: 2.7273% (minimum 75%, Missing); spinal cord: 69.8276% (minimum 75%, Missing)",0.0785714,0.160526,-0.722727,0,2,partial,288.9,3.3,5.9,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000079101,CLUL1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); choroid plexus: 22.5000% (minimum 75%, Missing); hippocampal formation: 71.6814% (minimum 75%, Missing); hypothalamus: 69.8276% (minimum 75%, Missing); midbrain: 74.3119% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); retina: 2.7273% (minimum 75%, Missing); spinal cord: 69.8276% (minimum 75%, Missing)",0.0785714,0.160526,-0.722727,0,2,partial,288.9,3.3,5.9,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000079101,CLUL1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); choroid plexus: 22.5000% (minimum 75%, Missing); hippocampal formation: 71.6814% (minimum 75%, Missing); hypothalamus: 69.8276% (minimum 75%, Missing); midbrain: 74.3119% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); retina: 2.7273% (minimum 75%, Missing); spinal cord: 69.8276% (minimum 75%, Missing)",0.0785714,0.160526,-0.722727,0,2,partial,288.9,3.3,5.9,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000079101,CLUL1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 68.0672% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.3226% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 22.5000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.6814% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.8276% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.8321% (minimum 75%, Baseline (adaptation disabled)); midbrain: 74.3119% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 69.2308% (minimum 75%, Baseline (adaptation disabled)); retina: 2.7273% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.8276% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 57.8571% (minimum 65%, Baseline (adaptation disabled))",-0.0714286,0.0105263,-0.722727,0,2,partial,288.9,3.3,5.9,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); kidney: 5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000079101,CLUL1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 78.4314% (minimum 95%, Enhanced); amygdala: 15.3257% (minimum 99%, Missing); basal ganglia: 33.3333% (minimum 99%, Missing); cerebellum: 5.9172% (minimum 95%, Enhanced); cerebral cortex: 13.6519% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); duodenum: 85.1064% (minimum 95%, Enhanced); esophagus: 66.6667% (minimum 80%, Enhanced); hippocampal formation: 17.4672% (minimum 99%, Missing); hypothalamus: 37.0370% (minimum 99%, Missing); midbrain: 46.5116% (minimum 99%, Missing); pancreas: 90.9091% (minimum 95%, Enhanced); parathyroid gland: 72.7273% (minimum 80%, Enhanced); pituitary gland: 63.4921% (minimum 99%, Missing); retina: 36.0360% (minimum 99%, Missing); small intestine: 90.9091% (minimum 95%, Enhanced); smooth muscle: 85.1064% (minimum 95%, Enhanced); spinal cord: 58.8235% (minimum 99%, Missing); stomach: 75.4717% (minimum 80%, Enhanced); tongue: 81.6327% (minimum 97%, Missing)",0.05,-0.153673,-0.890828,0,1,partial,63.6,2,0.2,"cerebellum: 63.6 nTPM (vital, limit 6); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000079841,RIMS1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 15.3257% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); cerebellum: 5.9172% (minimum 60%, Enhanced); cerebral cortex: 13.6519% (minimum 75%, Missing); hippocampal formation: 17.4672% (minimum 75%, Missing); hypothalamus: 37.0370% (minimum 75%, Missing); midbrain: 46.5116% (minimum 75%, Missing); pituitary gland: 63.4921% (minimum 75%, Missing); retina: 36.0360% (minimum 75%, Missing); spinal cord: 58.8235% (minimum 75%, Missing)",0.35,0.116327,-0.613481,0,1,partial,63.6,2,0.2,"cerebellum: 63.6 nTPM (vital, limit 6); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000079841,RIMS1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 15.3257% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); cerebellum: 5.9172% (minimum 60%, Enhanced); cerebral cortex: 13.6519% (minimum 75%, Missing); hippocampal formation: 17.4672% (minimum 75%, Missing); hypothalamus: 37.0370% (minimum 75%, Missing); midbrain: 46.5116% (minimum 75%, Missing); pituitary gland: 63.4921% (minimum 75%, Missing); retina: 36.0360% (minimum 75%, Missing); spinal cord: 58.8235% (minimum 75%, Missing)",0.35,0.116327,-0.613481,0,1,partial,63.6,2,0.2,"cerebellum: 63.6 nTPM (vital, limit 6); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000079841,RIMS1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 15.3257% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); cerebellum: 5.9172% (minimum 60%, Enhanced); cerebral cortex: 13.6519% (minimum 75%, Missing); hippocampal formation: 17.4672% (minimum 75%, Missing); hypothalamus: 37.0370% (minimum 75%, Missing); midbrain: 46.5116% (minimum 75%, Missing); pituitary gland: 63.4921% (minimum 75%, Missing); retina: 36.0360% (minimum 75%, Missing); spinal cord: 58.8235% (minimum 75%, Missing)",0.35,0.116327,-0.613481,0,1,partial,63.6,2,0.2,"cerebellum: 63.6 nTPM (vital, limit 6); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000079841,RIMS1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 15.3257% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 33.3333% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 5.9172% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 13.6519% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 17.4672% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 37.0370% (minimum 75%, Baseline (adaptation disabled)); midbrain: 46.5116% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 63.4921% (minimum 75%, Baseline (adaptation disabled)); retina: 36.0360% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 58.8235% (minimum 75%, Baseline (adaptation disabled))",0.302381,-0.0333333,-0.690828,0,1,partial,63.6,2,0.2,"cerebellum: 63.6 nTPM (vital, limit 1); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000079841,RIMS1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.4456% (minimum 99%, Missing); basal ganglia: 98.9583% (minimum 99%, Missing); choroid plexus: 96.4467% (minimum 99%, Missing); duodenum: 94.0594% (minimum 95%, Enhanced); hippocampal formation: 98.4456% (minimum 99%, Missing); hypothalamus: 98.4456% (minimum 99%, Missing); lung: 95.0000% (minimum 99%, Missing); midbrain: 96.9388% (minimum 99%, Missing); pancreas: 94.0594% (minimum 95%, Enhanced); pituitary gland: 98.4456% (minimum 99%, Missing); retina: 97.9381% (minimum 99%, Missing); spinal cord: 95.9596% (minimum 99%, Missing)",0.0395833,0.014456,-0.04,0,2,partial,1.2,1.8,1.4,,lung / macrophages: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080007,DDX43,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.339583,0.284456,0.2,0,2,partial,1.2,1.8,1.4,,lung / macrophages: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080007,DDX43,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.339583,0.284456,0.2,0,2,partial,1.2,1.8,1.4,,lung / macrophages: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080007,DDX43,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.339583,0.284456,0.2,0,2,partial,1.2,1.8,1.4,,lung / macrophages: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080007,DDX43,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.281373,0.213462,0.190594,0,2,partial,1.2,1.8,1.4,"duodenum: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080007,DDX43,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.9091% (minimum 99%, Missing); basal ganglia: 82.4742% (minimum 99%, Missing); bone marrow: 98.7654% (minimum 99%, Missing); cerebellum: 85.1064% (minimum 99%, Missing); cerebral cortex: 79.2079% (minimum 99%, Missing); colon: 72.0721% (minimum 97%, Missing); duodenum: 98.7654% (minimum 99%, Missing); esophagus: 90.9091% (minimum 97%, Missing); heart muscle: 96.3855% (minimum 99%, Missing); hippocampal formation: 91.9540% (minimum 99%, Missing); hypothalamus: 95.2381% (minimum 99%, Missing); kidney: 95.2381% (minimum 99%, Missing); lung: 98.7654% (minimum 99%, Missing); midbrain: 97.5610% (minimum 99%, Missing); pancreas: 94.1176% (minimum 99%, Missing); pituitary gland: 98.7654% (minimum 99%, Missing); rectum: 93.0233% (minimum 97%, Missing); retina: 87.9121% (minimum 99%, Missing); small intestine: 96.3855% (minimum 99%, Missing); smooth muscle: 85.1064% (minimum 99%, Missing); spinal cord: 98.7654% (minimum 99%, Missing); stomach: 93.0233% (minimum 97%, Missing); thyroid gland: 80.8081% (minimum 95%, Missing); urinary bladder: 86.0215% (minimum 97%, Missing)",-0.141919,-0.249279,-0.197921,0,80,unavailable,2.1,3.1,1.9,"colon: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080224,EPHA6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.158081,0.0207207,0.0420792,0,80,unavailable,2.1,3.1,1.9,"colon: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080224,EPHA6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.158081,0.0207207,0.0420792,0,80,unavailable,2.1,3.1,1.9,"colon: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080224,EPHA6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.158081,0.0207207,0.0420792,0,80,unavailable,2.1,3.1,1.9,"colon: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080224,EPHA6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.158081,0.0207207,0.0420792,0,80,unavailable,2.1,3.1,1.9,"colon: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080224,EPHA6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.8678% (minimum 99%, Missing); basal ganglia: 92.8000% (minimum 99%, Missing); choroid plexus: 74.8387% (minimum 99%, Missing); hippocampal formation: 92.8000% (minimum 99%, Missing); hypothalamus: 92.8000% (minimum 99%, Missing); lung: 90.6250% (minimum 95%, Enhanced); spinal cord: 98.3051% (minimum 99%, Missing)",0.05,0.03,-0.241613,0,7,partial,3.9,0,0.2,"choroid plexus: 3.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080572,DNAAF6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 74.8387% (minimum 75%, Missing)",0.35,0.3,-0.0016129,0,7,partial,3.9,0,0.2,"choroid plexus: 3.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080572,DNAAF6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 74.8387% (minimum 75%, Missing)",0.35,0.3,-0.0016129,0,7,partial,3.9,0,0.2,"choroid plexus: 3.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080572,DNAAF6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 74.8387% (minimum 75%, Missing)",0.35,0.3,-0.0016129,0,7,partial,3.9,0,0.2,"choroid plexus: 3.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080572,DNAAF6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 74.8387% (minimum 75%, Baseline (adaptation disabled))",0.333051,0.3,-0.0016129,0,7,partial,3.9,0,0.2,"choroid plexus: 3.9 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080572,DNAAF6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.7765% (minimum 90%, Approved); adrenal gland: 63.5644% (minimum 99%, Missing); amygdala: 55.9233% (minimum 99%, Missing); basal ganglia: 51.8578% (minimum 99%, Missing); bone marrow: 70.3947% (minimum 99%, Missing); cerebellum: 68.8841% (minimum 99%, Missing); cerebral cortex: 53.7688% (minimum 99%, Missing); choroid plexus: 62.8180% (minimum 99%, Missing); colon: 47.1366% (minimum 97%, Missing); duodenum: 45.2113% (minimum 99%, Missing); esophagus: 55.6326% (minimum 97%, Missing); heart muscle: 72.1348% (minimum 99%, Missing); hippocampal formation: 47.3451% (minimum 99%, Missing); hypothalamus: 58.3636% (minimum 99%, Missing); kidney: 55.1546% (minimum 99%, Missing); liver: 59.3346% (minimum 99%, Missing); lung: 56.9149% (minimum 99%, Missing); lymph node: 69.0323% (minimum 97%, Missing); midbrain: 44.8324% (minimum 99%, Missing); pancreas: 66.8750% (minimum 99%, Missing); parathyroid gland: 55.5363% (minimum 97%, Missing); pituitary gland: 74.6512% (minimum 99%, Missing); rectum: 49.1577% (minimum 97%, Missing); retina: 74.6512% (minimum 99%, Missing); salivary gland: 60.1124% (minimum 97%, Missing); skeletal muscle: 64.9798% (minimum 99%, Missing); skin: 49.3088% (minimum 95%, Missing); small intestine: 44.7075% (minimum 99%, Missing); smooth muscle: 61.1429% (minimum 99%, Missing); spinal cord: 28.3820% (minimum 99%, Missing); spleen: 63.8171% (minimum 95%, Missing); stomach: 58.1522% (minimum 97%, Missing); thymus: 62.5731% (minimum 95%, Missing); thyroid gland: 54.4992% (minimum 95%, Missing); tongue: 66.3223% (minimum 97%, Missing); urinary bladder: 56.2172% (minimum 97%, Missing)",-0.456912,-0.498634,-0.70618,0,5,partial,81,36,33,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 2); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 2); skin: 33 nTPM (manageable, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (manageable, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 2); esophagus: 25.6 nTPM (protected, limit 2); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 2); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 2); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 10); salivary gland: 21.3 nTPM (protected, limit 2); smooth muscle: 20.4 nTPM (vital, limit 1); thymus: 19.2 nTPM (manageable, limit 5); choroid plexus: 19 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 2); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 2); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080815,PSEN1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.7765% (minimum 60%, Approved); adrenal gland: 63.5644% (minimum 75%, Missing); amygdala: 55.9233% (minimum 75%, Missing); basal ganglia: 51.8578% (minimum 75%, Missing); bone marrow: 70.3947% (minimum 75%, Missing); cerebellum: 68.8841% (minimum 75%, Missing); cerebral cortex: 53.7688% (minimum 75%, Missing); choroid plexus: 62.8180% (minimum 75%, Missing); colon: 47.1366% (minimum 70%, Missing); duodenum: 45.2113% (minimum 75%, Missing); esophagus: 55.6326% (minimum 70%, Missing); heart muscle: 72.1348% (minimum 75%, Missing); hippocampal formation: 47.3451% (minimum 75%, Missing); hypothalamus: 58.3636% (minimum 75%, Missing); kidney: 55.1546% (minimum 75%, Missing); liver: 59.3346% (minimum 75%, Missing); lung: 56.9149% (minimum 75%, Missing); lymph node: 69.0323% (minimum 70%, Missing); midbrain: 44.8324% (minimum 75%, Missing); pancreas: 66.8750% (minimum 75%, Missing); parathyroid gland: 55.5363% (minimum 70%, Missing); pituitary gland: 74.6512% (minimum 75%, Missing); rectum: 49.1577% (minimum 70%, Missing); retina: 74.6512% (minimum 75%, Missing); salivary gland: 60.1124% (minimum 70%, Missing); skeletal muscle: 64.9798% (minimum 75%, Missing); skin: 49.3088% (minimum 65%, Missing); small intestine: 44.7075% (minimum 75%, Missing); smooth muscle: 61.1429% (minimum 75%, Missing); spinal cord: 28.3820% (minimum 75%, Missing); spleen: 63.8171% (minimum 65%, Missing); stomach: 58.1522% (minimum 70%, Missing); thymus: 62.5731% (minimum 65%, Missing); thyroid gland: 54.4992% (minimum 65%, Missing); tongue: 66.3223% (minimum 70%, Missing); urinary bladder: 56.2172% (minimum 70%, Missing)",-0.156912,-0.228634,-0.46618,0,5,partial,81,36,33,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 2); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 2); skin: 33 nTPM (manageable, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (manageable, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 2); esophagus: 25.6 nTPM (protected, limit 2); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 2); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 2); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 10); salivary gland: 21.3 nTPM (protected, limit 2); smooth muscle: 20.4 nTPM (vital, limit 1); thymus: 19.2 nTPM (manageable, limit 5); choroid plexus: 19 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 2); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 2); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080815,PSEN1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.7765% (minimum 60%, Approved); adrenal gland: 63.5644% (minimum 75%, Missing); amygdala: 55.9233% (minimum 75%, Missing); basal ganglia: 51.8578% (minimum 75%, Missing); bone marrow: 70.3947% (minimum 75%, Missing); cerebellum: 68.8841% (minimum 75%, Missing); cerebral cortex: 53.7688% (minimum 75%, Missing); choroid plexus: 62.8180% (minimum 75%, Missing); colon: 47.1366% (minimum 70%, Missing); duodenum: 45.2113% (minimum 75%, Missing); esophagus: 55.6326% (minimum 70%, Missing); heart muscle: 72.1348% (minimum 75%, Missing); hippocampal formation: 47.3451% (minimum 75%, Missing); hypothalamus: 58.3636% (minimum 75%, Missing); kidney: 55.1546% (minimum 75%, Missing); liver: 59.3346% (minimum 75%, Missing); lung: 56.9149% (minimum 75%, Missing); lymph node: 69.0323% (minimum 70%, Missing); midbrain: 44.8324% (minimum 75%, Missing); pancreas: 66.8750% (minimum 75%, Missing); parathyroid gland: 55.5363% (minimum 70%, Missing); pituitary gland: 74.6512% (minimum 75%, Missing); rectum: 49.1577% (minimum 70%, Missing); retina: 74.6512% (minimum 75%, Missing); salivary gland: 60.1124% (minimum 70%, Missing); skeletal muscle: 64.9798% (minimum 75%, Missing); skin: 49.3088% (minimum 65%, Missing); small intestine: 44.7075% (minimum 75%, Missing); smooth muscle: 61.1429% (minimum 75%, Missing); spinal cord: 28.3820% (minimum 75%, Missing); spleen: 63.8171% (minimum 65%, Missing); stomach: 58.1522% (minimum 70%, Missing); thymus: 62.5731% (minimum 65%, Missing); thyroid gland: 54.4992% (minimum 65%, Missing); tongue: 66.3223% (minimum 70%, Missing); urinary bladder: 56.2172% (minimum 70%, Missing)",-0.156912,-0.228634,-0.46618,0,5,partial,81,36,33,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 3); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 3); skin: 33 nTPM (manageable, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (manageable, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 3); esophagus: 25.6 nTPM (protected, limit 3); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 3); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 3); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 10); salivary gland: 21.3 nTPM (protected, limit 3); smooth muscle: 20.4 nTPM (vital, limit 1); thymus: 19.2 nTPM (manageable, limit 5); choroid plexus: 19 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 3); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 3); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080815,PSEN1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.7765% (minimum 60%, Approved); adrenal gland: 63.5644% (minimum 75%, Missing); amygdala: 55.9233% (minimum 75%, Missing); basal ganglia: 51.8578% (minimum 75%, Missing); bone marrow: 70.3947% (minimum 75%, Missing); cerebellum: 68.8841% (minimum 75%, Missing); cerebral cortex: 53.7688% (minimum 75%, Missing); choroid plexus: 62.8180% (minimum 75%, Missing); colon: 47.1366% (minimum 70%, Missing); duodenum: 45.2113% (minimum 75%, Missing); esophagus: 55.6326% (minimum 70%, Missing); heart muscle: 72.1348% (minimum 75%, Missing); hippocampal formation: 47.3451% (minimum 75%, Missing); hypothalamus: 58.3636% (minimum 75%, Missing); kidney: 55.1546% (minimum 75%, Missing); liver: 59.3346% (minimum 75%, Missing); lung: 56.9149% (minimum 75%, Missing); lymph node: 69.0323% (minimum 70%, Missing); midbrain: 44.8324% (minimum 75%, Missing); pancreas: 66.8750% (minimum 75%, Missing); parathyroid gland: 55.5363% (minimum 70%, Missing); pituitary gland: 74.6512% (minimum 75%, Missing); rectum: 49.1577% (minimum 70%, Missing); retina: 74.6512% (minimum 75%, Missing); salivary gland: 60.1124% (minimum 70%, Missing); skeletal muscle: 64.9798% (minimum 75%, Missing); skin: 49.3088% (minimum 65%, Missing); small intestine: 44.7075% (minimum 75%, Missing); smooth muscle: 61.1429% (minimum 75%, Missing); spinal cord: 28.3820% (minimum 75%, Missing); spleen: 63.8171% (minimum 65%, Missing); stomach: 58.1522% (minimum 70%, Missing); thymus: 62.5731% (minimum 65%, Missing); thyroid gland: 54.4992% (minimum 65%, Missing); tongue: 66.3223% (minimum 70%, Missing); urinary bladder: 56.2172% (minimum 70%, Missing)",-0.156912,-0.228634,-0.46618,0,5,partial,81,36,33,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 3); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 3); skin: 33 nTPM (manageable, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (manageable, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 3); esophagus: 25.6 nTPM (protected, limit 3); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 3); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 3); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 10); salivary gland: 21.3 nTPM (protected, limit 3); smooth muscle: 20.4 nTPM (vital, limit 1); thymus: 19.2 nTPM (manageable, limit 5); choroid plexus: 19 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 3); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 3); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080815,PSEN1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.7765% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.5644% (minimum 75%, Baseline (adaptation disabled)); amygdala: 55.9233% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 51.8578% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 70.3947% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.8841% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.7688% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 62.8180% (minimum 75%, Baseline (adaptation disabled)); colon: 47.1366% (minimum 70%, Baseline (adaptation disabled)); duodenum: 45.2113% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.6326% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 72.1348% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 47.3451% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.3636% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.1546% (minimum 75%, Baseline (adaptation disabled)); liver: 59.3346% (minimum 75%, Baseline (adaptation disabled)); lung: 56.9149% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.0323% (minimum 70%, Baseline (adaptation disabled)); midbrain: 44.8324% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.8750% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.5363% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 74.6512% (minimum 75%, Baseline (adaptation disabled)); rectum: 49.1577% (minimum 70%, Baseline (adaptation disabled)); retina: 74.6512% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.1124% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 64.9798% (minimum 75%, Baseline (adaptation disabled)); skin: 49.3088% (minimum 65%, Baseline (adaptation disabled)); small intestine: 44.7075% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.1429% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 28.3820% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.8171% (minimum 65%, Baseline (adaptation disabled)); stomach: 58.1522% (minimum 70%, Baseline (adaptation disabled)); thymus: 62.5731% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.4992% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.3223% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.2172% (minimum 70%, Baseline (adaptation disabled))",-0.156912,-0.228634,-0.46618,0,5,partial,81,36,33,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 3); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 3); skin: 33 nTPM (manageable, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (manageable, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 3); esophagus: 25.6 nTPM (protected, limit 3); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 3); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 3); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); salivary gland: 21.3 nTPM (protected, limit 3); smooth muscle: 20.4 nTPM (vital, limit 1); thymus: 19.2 nTPM (manageable, limit 5); choroid plexus: 19 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 3); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 3); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080815,PSEN1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.7500% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 18.7500% (minimum 99%, Missing); cerebellum: 56.8966% (minimum 99%, Missing); cerebral cortex: 70.2128% (minimum 99%, Missing); choroid plexus: 78.5714% (minimum 99%, Missing); colon: 55.0000% (minimum 97%, Missing); duodenum: 58.9286% (minimum 99%, Missing); esophagus: 54.0984% (minimum 97%, Missing); heart muscle: 66.0000% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 76.7442% (minimum 99%, Missing); kidney: 67.3469% (minimum 99%, Missing); liver: 71.7391% (minimum 99%, Missing); lung: 61.1111% (minimum 99%, Missing); lymph node: 31.7308% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 58.9286% (minimum 99%, Missing); parathyroid gland: 56.8966% (minimum 97%, Missing); pituitary gland: 75.0000% (minimum 99%, Missing); rectum: 49.2537% (minimum 97%, Missing); retina: 45.8333% (minimum 99%, Missing); salivary gland: 70.2128% (minimum 97%, Missing); skeletal muscle: 33.0000% (minimum 99%, Missing); skin: 51.5625% (minimum 95%, Missing); small intestine: 57.8947% (minimum 99%, Missing); smooth muscle: 55.0000% (minimum 99%, Missing); spinal cord: 68.7500% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 55.9322% (minimum 97%, Missing); thymus: 27.9661% (minimum 95%, Missing); thyroid gland: 55.9322% (minimum 95%, Missing); tongue: 30.2752% (minimum 97%, Missing); urinary bladder: 63.4615% (minimum 97%, Missing)",-0.670339,-0.667248,-0.8025,0,9,partial,14.3,7.6,8.5,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 7.6 nTPM (protected, limit 2); lymph node: 7.1 nTPM (protected, limit 2); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080839,RBL1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.7500% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 18.7500% (minimum 75%, Missing); cerebellum: 56.8966% (minimum 75%, Missing); cerebral cortex: 70.2128% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 58.9286% (minimum 75%, Missing); esophagus: 54.0984% (minimum 70%, Missing); heart muscle: 66.0000% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); kidney: 67.3469% (minimum 75%, Missing); liver: 71.7391% (minimum 75%, Missing); lung: 61.1111% (minimum 75%, Missing); lymph node: 31.7308% (minimum 70%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pancreas: 58.9286% (minimum 75%, Missing); parathyroid gland: 56.8966% (minimum 70%, Missing); pituitary gland: 75.0000% (minimum 75%, Missing); rectum: 49.2537% (minimum 70%, Missing); retina: 45.8333% (minimum 75%, Missing); skeletal muscle: 33.0000% (minimum 75%, Missing); skin: 51.5625% (minimum 65%, Missing); small intestine: 57.8947% (minimum 75%, Missing); smooth muscle: 55.0000% (minimum 75%, Missing); spinal cord: 68.7500% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 55.9322% (minimum 70%, Missing); thymus: 27.9661% (minimum 65%, Missing); thyroid gland: 55.9322% (minimum 65%, Missing); tongue: 30.2752% (minimum 70%, Missing); urinary bladder: 63.4615% (minimum 70%, Missing)",-0.370339,-0.397248,-0.5625,0,9,partial,14.3,7.6,8.5,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 7.6 nTPM (protected, limit 2); lymph node: 7.1 nTPM (protected, limit 2); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080839,RBL1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.7500% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 18.7500% (minimum 75%, Missing); cerebellum: 56.8966% (minimum 75%, Missing); cerebral cortex: 70.2128% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 58.9286% (minimum 75%, Missing); esophagus: 54.0984% (minimum 70%, Missing); heart muscle: 66.0000% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); kidney: 67.3469% (minimum 75%, Missing); liver: 71.7391% (minimum 75%, Missing); lung: 61.1111% (minimum 75%, Missing); lymph node: 31.7308% (minimum 70%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pancreas: 58.9286% (minimum 75%, Missing); parathyroid gland: 56.8966% (minimum 70%, Missing); pituitary gland: 75.0000% (minimum 75%, Missing); rectum: 49.2537% (minimum 70%, Missing); retina: 45.8333% (minimum 75%, Missing); skeletal muscle: 33.0000% (minimum 75%, Missing); skin: 51.5625% (minimum 65%, Missing); small intestine: 57.8947% (minimum 75%, Missing); smooth muscle: 55.0000% (minimum 75%, Missing); spinal cord: 68.7500% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 55.9322% (minimum 70%, Missing); thymus: 27.9661% (minimum 65%, Missing); thyroid gland: 55.9322% (minimum 65%, Missing); tongue: 30.2752% (minimum 70%, Missing); urinary bladder: 63.4615% (minimum 70%, Missing)",-0.370339,-0.397248,-0.5625,0,9,partial,14.3,7.6,8.5,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 7.6 nTPM (protected, limit 3); lymph node: 7.1 nTPM (protected, limit 3); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080839,RBL1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.7500% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 18.7500% (minimum 75%, Missing); cerebellum: 56.8966% (minimum 75%, Missing); cerebral cortex: 70.2128% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 58.9286% (minimum 75%, Missing); esophagus: 54.0984% (minimum 70%, Missing); heart muscle: 66.0000% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); kidney: 67.3469% (minimum 75%, Missing); liver: 71.7391% (minimum 75%, Missing); lung: 61.1111% (minimum 75%, Missing); lymph node: 31.7308% (minimum 70%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pancreas: 58.9286% (minimum 75%, Missing); parathyroid gland: 56.8966% (minimum 70%, Missing); pituitary gland: 75.0000% (minimum 75%, Missing); rectum: 49.2537% (minimum 70%, Missing); retina: 45.8333% (minimum 75%, Missing); skeletal muscle: 33.0000% (minimum 75%, Missing); skin: 51.5625% (minimum 65%, Missing); small intestine: 57.8947% (minimum 75%, Missing); smooth muscle: 55.0000% (minimum 75%, Missing); spinal cord: 68.7500% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 55.9322% (minimum 70%, Missing); thymus: 27.9661% (minimum 65%, Missing); thyroid gland: 55.9322% (minimum 65%, Missing); tongue: 30.2752% (minimum 70%, Missing); urinary bladder: 63.4615% (minimum 70%, Missing)",-0.370339,-0.397248,-0.5625,0,9,partial,14.3,7.6,8.5,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 7.6 nTPM (protected, limit 3); lymph node: 7.1 nTPM (protected, limit 3); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080839,RBL1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.2642% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 68.7500% (minimum 75%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 18.7500% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.8966% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.2128% (minimum 75%, Baseline (adaptation disabled)); colon: 55.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.9286% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.0984% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.3469% (minimum 75%, Baseline (adaptation disabled)); liver: 71.7391% (minimum 75%, Baseline (adaptation disabled)); lung: 61.1111% (minimum 75%, Baseline (adaptation disabled)); lymph node: 31.7308% (minimum 70%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.9286% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 56.8966% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 75.0000% (minimum 75%, Baseline (adaptation disabled)); rectum: 49.2537% (minimum 70%, Baseline (adaptation disabled)); retina: 45.8333% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 33.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 51.5625% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.8947% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.7500% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.9322% (minimum 70%, Baseline (adaptation disabled)); thymus: 27.9661% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.9322% (minimum 65%, Baseline (adaptation disabled)); tongue: 30.2752% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.4615% (minimum 70%, Baseline (adaptation disabled))",-0.370339,-0.397248,-0.5625,0,9,partial,14.3,7.6,8.5,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 7.6 nTPM (protected, limit 3); lymph node: 7.1 nTPM (protected, limit 3); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000080839,RBL1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 95%, Enhanced); amygdala: 42.8571% (minimum 99%, Missing); basal ganglia: 31.5789% (minimum 99%, Missing); cerebellum: 16.6667% (minimum 99%, Missing); cerebral cortex: 20.0000% (minimum 99%, Missing); choroid plexus: 85.7143% (minimum 99%, Missing); duodenum: 75.0000% (minimum 95%, Enhanced); heart muscle: 85.7143% (minimum 95%, Enhanced); hippocampal formation: 37.5000% (minimum 99%, Missing); hypothalamus: 30.0000% (minimum 99%, Missing); kidney: 60.0000% (minimum 95%, Enhanced); lung: 75.0000% (minimum 95%, Enhanced); midbrain: 42.8571% (minimum 99%, Missing); pancreas: 37.5000% (minimum 95%, Enhanced); parathyroid gland: 30.0000% (minimum 80%, Enhanced); pituitary gland: 28.5714% (minimum 99%, Missing); retina: 35.2941% (minimum 99%, Missing); small intestine: 75.0000% (minimum 95%, Enhanced); smooth muscle: 75.0000% (minimum 95%, Enhanced); spinal cord: 31.5789% (minimum 99%, Missing)",0.05,-0.5,-0.823333,0,3,partial,3,1.4,0.2,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000081842,PCDHA6,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.8571% (minimum 75%, Missing); basal ganglia: 31.5789% (minimum 75%, Missing); cerebellum: 16.6667% (minimum 75%, Missing); cerebral cortex: 20.0000% (minimum 75%, Missing); hippocampal formation: 37.5000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 42.8571% (minimum 75%, Missing); pancreas: 37.5000% (minimum 60%, Enhanced); parathyroid gland: 30.0000% (minimum 55%, Enhanced); pituitary gland: 28.5714% (minimum 75%, Missing); retina: 35.2941% (minimum 75%, Missing); spinal cord: 31.5789% (minimum 75%, Missing)",0.25,-0.25,-0.583333,0,3,partial,3,1.4,0.2,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000081842,PCDHA6,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.8571% (minimum 75%, Missing); basal ganglia: 31.5789% (minimum 75%, Missing); cerebellum: 16.6667% (minimum 75%, Missing); cerebral cortex: 20.0000% (minimum 75%, Missing); hippocampal formation: 37.5000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 42.8571% (minimum 75%, Missing); pancreas: 37.5000% (minimum 60%, Enhanced); parathyroid gland: 30.0000% (minimum 55%, Enhanced); pituitary gland: 28.5714% (minimum 75%, Missing); retina: 35.2941% (minimum 75%, Missing); spinal cord: 31.5789% (minimum 75%, Missing)",0.25,-0.25,-0.583333,0,3,partial,3,1.4,0.2,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000081842,PCDHA6,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.8571% (minimum 75%, Missing); basal ganglia: 31.5789% (minimum 75%, Missing); cerebellum: 16.6667% (minimum 75%, Missing); cerebral cortex: 20.0000% (minimum 75%, Missing); hippocampal formation: 37.5000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 42.8571% (minimum 75%, Missing); pancreas: 37.5000% (minimum 60%, Enhanced); parathyroid gland: 30.0000% (minimum 55%, Enhanced); pituitary gland: 28.5714% (minimum 75%, Missing); retina: 35.2941% (minimum 75%, Missing); spinal cord: 31.5789% (minimum 75%, Missing)",0.25,-0.25,-0.583333,0,3,partial,3,1.4,0.2,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000081842,PCDHA6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); amygdala: 42.8571% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 31.5789% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 16.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 20.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 37.5000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 30.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 42.8571% (minimum 75%, Baseline (adaptation disabled)); pancreas: 37.5000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 30.0000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 28.5714% (minimum 75%, Baseline (adaptation disabled)); retina: 35.2941% (minimum 75%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 31.5789% (minimum 75%, Baseline (adaptation disabled))",0.1,-0.4,-0.583333,0,3,partial,3,1.4,0.2,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000081842,PCDHA6,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.0123% (minimum 95%, Missing); adrenal gland: 96.9697% (minimum 99%, Missing); amygdala: 96.9697% (minimum 99%, Missing); bone marrow: 92.7536% (minimum 99%, Missing); cerebral cortex: 76.1905% (minimum 99%, Missing); choroid plexus: 98.4615% (minimum 99%, Missing); colon: 95.5224% (minimum 97%, Missing); duodenum: 96.9697% (minimum 99%, Missing); esophagus: 90.1408% (minimum 97%, Missing); heart muscle: 98.4615% (minimum 99%, Missing); hippocampal formation: 86.4865% (minimum 99%, Missing); hypothalamus: 98.4615% (minimum 99%, Missing); kidney: 95.5224% (minimum 99%, Missing); liver: 90.1408% (minimum 99%, Missing); lung: 94.1176% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); pancreas: 71.9101% (minimum 99%, Missing); parathyroid gland: 92.7536% (minimum 97%, Missing); rectum: 95.5224% (minimum 97%, Missing); retina: 98.4615% (minimum 99%, Missing); salivary gland: 86.4865% (minimum 97%, Missing); skeletal muscle: 65.3061% (minimum 99%, Missing); skin: 86.4865% (minimum 95%, Missing); small intestine: 95.5224% (minimum 99%, Missing); smooth muscle: 94.1176% (minimum 99%, Missing); spleen: 85.3333% (minimum 95%, Missing); stomach: 96.9697% (minimum 97%, Missing); thymus: 87.6712% (minimum 95%, Missing); tongue: 88.8889% (minimum 97%, Missing); urinary bladder: 91.4286% (minimum 97%, Missing)",-0.159877,-0.17,-0.336939,0,80,unavailable,3.4,1.6,1.7,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000081985,IL12RB2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 71.9101% (minimum 75%, Missing); skeletal muscle: 65.3061% (minimum 75%, Missing)",0.140123,0.1,-0.0969388,0,80,unavailable,3.4,1.6,1.7,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000081985,IL12RB2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 71.9101% (minimum 75%, Missing); skeletal muscle: 65.3061% (minimum 75%, Missing)",0.140123,0.1,-0.0969388,0,80,unavailable,3.4,1.6,1.7,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000081985,IL12RB2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 71.9101% (minimum 75%, Missing); skeletal muscle: 65.3061% (minimum 75%, Missing)",0.140123,0.1,-0.0969388,0,80,unavailable,3.4,1.6,1.7,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000081985,IL12RB2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 71.9101% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 65.3061% (minimum 75%, Baseline (adaptation disabled))",0.140123,0.1,-0.0969388,0,80,unavailable,3.4,1.6,1.7,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000081985,IL12RB2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.7407% (minimum 95%, Enhanced); amygdala: 49.0000% (minimum 99%, Missing); basal ganglia: 56.9767% (minimum 99%, Missing); cerebellum: 27.3743% (minimum 95%, Enhanced); cerebral cortex: 56.9767% (minimum 95%, Enhanced); choroid plexus: 0.7187% (minimum 99%, Missing); duodenum: 94.2308% (minimum 95%, Enhanced); heart muscle: 85.9649% (minimum 95%, Enhanced); hippocampal formation: 55.6818% (minimum 99%, Missing); hypothalamus: 48.5149% (minimum 99%, Missing); kidney: 24.6231% (minimum 99%, Missing); midbrain: 37.9845% (minimum 99%, Missing); pancreas: 94.2308% (minimum 95%, Enhanced); pituitary gland: 63.6364% (minimum 99%, Missing); retina: 20.6751% (minimum 99%, Missing); spinal cord: 61.2500% (minimum 99%, Missing)",0.03,0.01,-0.982813,0,4,partial,676.9,0.4,0.8,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 6); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083067,TRPM3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 49.0000% (minimum 75%, Missing); basal ganglia: 56.9767% (minimum 75%, Missing); cerebellum: 27.3743% (minimum 60%, Enhanced); cerebral cortex: 56.9767% (minimum 60%, Enhanced); choroid plexus: 0.7187% (minimum 75%, Missing); hippocampal formation: 55.6818% (minimum 75%, Missing); hypothalamus: 48.5149% (minimum 75%, Missing); kidney: 24.6231% (minimum 75%, Missing); midbrain: 37.9845% (minimum 75%, Missing); pituitary gland: 63.6364% (minimum 75%, Missing); retina: 20.6751% (minimum 75%, Missing); spinal cord: 61.2500% (minimum 75%, Missing)",0.33,0.28,-0.742813,0,4,partial,676.9,0.4,0.8,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 6); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083067,TRPM3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 49.0000% (minimum 75%, Missing); basal ganglia: 56.9767% (minimum 75%, Missing); cerebellum: 27.3743% (minimum 60%, Enhanced); cerebral cortex: 56.9767% (minimum 60%, Enhanced); choroid plexus: 0.7187% (minimum 75%, Missing); hippocampal formation: 55.6818% (minimum 75%, Missing); hypothalamus: 48.5149% (minimum 75%, Missing); kidney: 24.6231% (minimum 75%, Missing); midbrain: 37.9845% (minimum 75%, Missing); pituitary gland: 63.6364% (minimum 75%, Missing); retina: 20.6751% (minimum 75%, Missing); spinal cord: 61.2500% (minimum 75%, Missing)",0.33,0.28,-0.742813,0,4,partial,676.9,0.4,0.8,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 6); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083067,TRPM3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 49.0000% (minimum 75%, Missing); basal ganglia: 56.9767% (minimum 75%, Missing); cerebellum: 27.3743% (minimum 60%, Enhanced); cerebral cortex: 56.9767% (minimum 60%, Enhanced); choroid plexus: 0.7187% (minimum 75%, Missing); hippocampal formation: 55.6818% (minimum 75%, Missing); hypothalamus: 48.5149% (minimum 75%, Missing); kidney: 24.6231% (minimum 75%, Missing); midbrain: 37.9845% (minimum 75%, Missing); pituitary gland: 63.6364% (minimum 75%, Missing); retina: 20.6751% (minimum 75%, Missing); spinal cord: 61.2500% (minimum 75%, Missing)",0.33,0.28,-0.742813,0,4,partial,676.9,0.4,0.8,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 6); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083067,TRPM3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 49.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.9767% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 27.3743% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.9767% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 0.7187% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.6818% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 48.5149% (minimum 75%, Baseline (adaptation disabled)); kidney: 24.6231% (minimum 75%, Baseline (adaptation disabled)); midbrain: 37.9845% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 63.6364% (minimum 75%, Baseline (adaptation disabled)); retina: 20.6751% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.2500% (minimum 75%, Baseline (adaptation disabled))",0.209649,0.224528,-0.742813,0,4,partial,676.9,0.4,0.8,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083067,TRPM3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.2791% (minimum 95%, Missing); adrenal gland: 83.0380% (minimum 99%, Missing); amygdala: 64.3137% (minimum 99%, Missing); basal ganglia: 67.3511% (minimum 99%, Missing); bone marrow: 91.6201% (minimum 99%, Missing); cerebellum: 64.4401% (minimum 99%, Missing); cerebral cortex: 64.9505% (minimum 99%, Missing); choroid plexus: 73.5426% (minimum 99%, Missing); colon: 75.7506% (minimum 97%, Missing); duodenum: 91.8768% (minimum 99%, Missing); esophagus: 84.3188% (minimum 97%, Missing); heart muscle: 80.3922% (minimum 99%, Missing); hippocampal formation: 64.8221% (minimum 99%, Missing); hypothalamus: 70.9957% (minimum 99%, Missing); kidney: 83.6735% (minimum 99%, Missing); liver: 90.8587% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 87.4667% (minimum 97%, Missing); midbrain: 62.0038% (minimum 99%, Missing); pancreas: 81.7955% (minimum 99%, Missing); parathyroid gland: 71.9298% (minimum 97%, Missing); pituitary gland: 86.3158% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 78.0952% (minimum 99%, Missing); salivary gland: 85.1948% (minimum 97%, Missing); skeletal muscle: 69.0526% (minimum 99%, Missing); skin: 81.7955% (minimum 95%, Missing); small intestine: 87.9357% (minimum 99%, Missing); smooth muscle: 78.0952% (minimum 99%, Missing); spinal cord: 47.7438% (minimum 99%, Missing); spleen: 82.4121% (minimum 95%, Missing); stomach: 82.0000% (minimum 97%, Missing); thymus: 89.6175% (minimum 95%, Missing); thyroid gland: 84.1026% (minimum 95%, Missing); tongue: 69.9360% (minimum 97%, Missing); urinary bladder: 79.0361% (minimum 97%, Missing)",-0.187209,-0.27064,-0.512562,0,1,partial,35.9,14.1,10.2,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 2); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 2); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 2); adipose tissue: 10.2 nTPM (manageable, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 2); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pancreas: 7.3 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); esophagus: 6.1 nTPM (protected, limit 2); salivary gland: 5.7 nTPM (protected, limit 2); pituitary gland: 5.2 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083290,ULK2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 64.3137% (minimum 75%, Missing); basal ganglia: 67.3511% (minimum 75%, Missing); cerebellum: 64.4401% (minimum 75%, Missing); cerebral cortex: 64.9505% (minimum 75%, Missing); choroid plexus: 73.5426% (minimum 75%, Missing); hippocampal formation: 64.8221% (minimum 75%, Missing); hypothalamus: 70.9957% (minimum 75%, Missing); midbrain: 62.0038% (minimum 75%, Missing); skeletal muscle: 69.0526% (minimum 75%, Missing); spinal cord: 47.7438% (minimum 75%, Missing); tongue: 69.9360% (minimum 70%, Missing)",0.112791,-0.000639659,-0.272562,0,1,partial,35.9,14.1,10.2,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 2); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 2); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 2); adipose tissue: 10.2 nTPM (manageable, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 2); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pancreas: 7.3 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); esophagus: 6.1 nTPM (protected, limit 2); salivary gland: 5.7 nTPM (protected, limit 2); pituitary gland: 5.2 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083290,ULK2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 64.3137% (minimum 75%, Missing); basal ganglia: 67.3511% (minimum 75%, Missing); cerebellum: 64.4401% (minimum 75%, Missing); cerebral cortex: 64.9505% (minimum 75%, Missing); choroid plexus: 73.5426% (minimum 75%, Missing); hippocampal formation: 64.8221% (minimum 75%, Missing); hypothalamus: 70.9957% (minimum 75%, Missing); midbrain: 62.0038% (minimum 75%, Missing); skeletal muscle: 69.0526% (minimum 75%, Missing); spinal cord: 47.7438% (minimum 75%, Missing); tongue: 69.9360% (minimum 70%, Missing)",0.112791,-0.000639659,-0.272562,0,1,partial,35.9,14.1,10.2,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 3); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 3); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 3); adipose tissue: 10.2 nTPM (manageable, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 3); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pancreas: 7.3 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); esophagus: 6.1 nTPM (protected, limit 3); salivary gland: 5.7 nTPM (protected, limit 3); pituitary gland: 5.2 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083290,ULK2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 64.3137% (minimum 75%, Missing); basal ganglia: 67.3511% (minimum 75%, Missing); cerebellum: 64.4401% (minimum 75%, Missing); cerebral cortex: 64.9505% (minimum 75%, Missing); choroid plexus: 73.5426% (minimum 75%, Missing); hippocampal formation: 64.8221% (minimum 75%, Missing); hypothalamus: 70.9957% (minimum 75%, Missing); midbrain: 62.0038% (minimum 75%, Missing); skeletal muscle: 69.0526% (minimum 75%, Missing); spinal cord: 47.7438% (minimum 75%, Missing); tongue: 69.9360% (minimum 70%, Missing)",0.112791,-0.000639659,-0.272562,0,1,partial,35.9,14.1,10.2,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 3); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 3); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 3); adipose tissue: 10.2 nTPM (manageable, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 3); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pancreas: 7.3 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); esophagus: 6.1 nTPM (protected, limit 3); salivary gland: 5.7 nTPM (protected, limit 3); pituitary gland: 5.2 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083290,ULK2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 64.3137% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 67.3511% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.4401% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.9505% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.5426% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.8221% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 70.9957% (minimum 75%, Baseline (adaptation disabled)); midbrain: 62.0038% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 69.0526% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 47.7438% (minimum 75%, Baseline (adaptation disabled)); tongue: 69.9360% (minimum 70%, Baseline (adaptation disabled))",0.112791,-0.000639659,-0.272562,0,1,partial,35.9,14.1,10.2,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 3); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 3); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 3); adipose tissue: 10.2 nTPM (manageable, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 3); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pancreas: 7.3 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); esophagus: 6.1 nTPM (protected, limit 3); salivary gland: 5.7 nTPM (protected, limit 3); pituitary gland: 5.2 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083290,ULK2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.1818% (minimum 95%, Missing); adrenal gland: 67.1642% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 66.1765% (minimum 99%, Missing); bone marrow: 63.3803% (minimum 99%, Missing); cerebellum: 57.6923% (minimum 99%, Missing); cerebral cortex: 68.1818% (minimum 99%, Missing); choroid plexus: 64.2857% (minimum 99%, Missing); colon: 67.1642% (minimum 97%, Missing); duodenum: 77.5862% (minimum 99%, Missing); esophagus: 59.2105% (minimum 97%, Missing); heart muscle: 63.3803% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 73.7705% (minimum 99%, Missing); kidney: 64.2857% (minimum 99%, Missing); liver: 69.2308% (minimum 99%, Missing); lung: 65.2174% (minimum 99%, Missing); lymph node: 62.5000% (minimum 97%, Missing); midbrain: 78.9474% (minimum 99%, Missing); pancreas: 77.5862% (minimum 99%, Missing); parathyroid gland: 51.1364% (minimum 97%, Missing); pituitary gland: 69.2308% (minimum 99%, Missing); rectum: 69.2308% (minimum 97%, Missing); retina: 55.5556% (minimum 99%, Missing); salivary gland: 68.1818% (minimum 97%, Missing); skeletal muscle: 64.2857% (minimum 99%, Missing); skin: 47.8723% (minimum 95%, Missing); small intestine: 73.7705% (minimum 99%, Missing); smooth muscle: 62.5000% (minimum 99%, Missing); spinal cord: 80.3571% (minimum 99%, Missing); spleen: 62.5000% (minimum 95%, Missing); stomach: 68.1818% (minimum 97%, Missing); thymus: 53.5714% (minimum 95%, Missing); thyroid gland: 56.2500% (minimum 95%, Missing); tongue: 60.8108% (minimum 97%, Missing); urinary bladder: 66.1765% (minimum 97%, Missing)",-0.471277,-0.458636,-0.434444,0,80,unavailable,3.6,4.3,4.9,"parathyroid gland: 4.3 nTPM (protected, limit 2); retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); basal ganglia: 2.3 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083817,ZNF416,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.1642% (minimum 75%, Missing); basal ganglia: 66.1765% (minimum 75%, Missing); bone marrow: 63.3803% (minimum 75%, Missing); cerebellum: 57.6923% (minimum 75%, Missing); cerebral cortex: 68.1818% (minimum 75%, Missing); choroid plexus: 64.2857% (minimum 75%, Missing); colon: 67.1642% (minimum 70%, Missing); esophagus: 59.2105% (minimum 70%, Missing); heart muscle: 63.3803% (minimum 75%, Missing); hypothalamus: 73.7705% (minimum 75%, Missing); kidney: 64.2857% (minimum 75%, Missing); liver: 69.2308% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); parathyroid gland: 51.1364% (minimum 70%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); rectum: 69.2308% (minimum 70%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 64.2857% (minimum 75%, Missing); skin: 47.8723% (minimum 65%, Missing); small intestine: 73.7705% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 68.1818% (minimum 70%, Missing); thymus: 53.5714% (minimum 65%, Missing); thyroid gland: 56.2500% (minimum 65%, Missing); tongue: 60.8108% (minimum 70%, Missing); urinary bladder: 66.1765% (minimum 70%, Missing)",-0.171277,-0.188636,-0.194444,0,80,unavailable,3.6,4.3,4.9,"parathyroid gland: 4.3 nTPM (protected, limit 2); retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); basal ganglia: 2.3 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083817,ZNF416,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.1642% (minimum 75%, Missing); basal ganglia: 66.1765% (minimum 75%, Missing); bone marrow: 63.3803% (minimum 75%, Missing); cerebellum: 57.6923% (minimum 75%, Missing); cerebral cortex: 68.1818% (minimum 75%, Missing); choroid plexus: 64.2857% (minimum 75%, Missing); colon: 67.1642% (minimum 70%, Missing); esophagus: 59.2105% (minimum 70%, Missing); heart muscle: 63.3803% (minimum 75%, Missing); hypothalamus: 73.7705% (minimum 75%, Missing); kidney: 64.2857% (minimum 75%, Missing); liver: 69.2308% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); parathyroid gland: 51.1364% (minimum 70%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); rectum: 69.2308% (minimum 70%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 64.2857% (minimum 75%, Missing); skin: 47.8723% (minimum 65%, Missing); small intestine: 73.7705% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 68.1818% (minimum 70%, Missing); thymus: 53.5714% (minimum 65%, Missing); thyroid gland: 56.2500% (minimum 65%, Missing); tongue: 60.8108% (minimum 70%, Missing); urinary bladder: 66.1765% (minimum 70%, Missing)",-0.171277,-0.188636,-0.194444,0,80,unavailable,3.6,4.3,4.9,"parathyroid gland: 4.3 nTPM (protected, limit 3); retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083817,ZNF416,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.1642% (minimum 75%, Missing); basal ganglia: 66.1765% (minimum 75%, Missing); bone marrow: 63.3803% (minimum 75%, Missing); cerebellum: 57.6923% (minimum 75%, Missing); cerebral cortex: 68.1818% (minimum 75%, Missing); choroid plexus: 64.2857% (minimum 75%, Missing); colon: 67.1642% (minimum 70%, Missing); esophagus: 59.2105% (minimum 70%, Missing); heart muscle: 63.3803% (minimum 75%, Missing); hypothalamus: 73.7705% (minimum 75%, Missing); kidney: 64.2857% (minimum 75%, Missing); liver: 69.2308% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); parathyroid gland: 51.1364% (minimum 70%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); rectum: 69.2308% (minimum 70%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 64.2857% (minimum 75%, Missing); skin: 47.8723% (minimum 65%, Missing); small intestine: 73.7705% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 68.1818% (minimum 70%, Missing); thymus: 53.5714% (minimum 65%, Missing); thyroid gland: 56.2500% (minimum 65%, Missing); tongue: 60.8108% (minimum 70%, Missing); urinary bladder: 66.1765% (minimum 70%, Missing)",-0.171277,-0.188636,-0.194444,0,80,unavailable,3.6,4.3,4.9,"parathyroid gland: 4.3 nTPM (protected, limit 3); retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083817,ZNF416,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.1642% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.1765% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 63.3803% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.6923% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.1818% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.2857% (minimum 75%, Baseline (adaptation disabled)); colon: 67.1642% (minimum 70%, Baseline (adaptation disabled)); esophagus: 59.2105% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.3803% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.7705% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.2857% (minimum 75%, Baseline (adaptation disabled)); liver: 69.2308% (minimum 75%, Baseline (adaptation disabled)); lung: 65.2174% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.5000% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 51.1364% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.2308% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.2308% (minimum 70%, Baseline (adaptation disabled)); retina: 55.5556% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.1818% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 64.2857% (minimum 75%, Baseline (adaptation disabled)); skin: 47.8723% (minimum 65%, Baseline (adaptation disabled)); small intestine: 73.7705% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 65%, Baseline (adaptation disabled)); stomach: 68.1818% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.5714% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.2500% (minimum 65%, Baseline (adaptation disabled)); tongue: 60.8108% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 66.1765% (minimum 70%, Baseline (adaptation disabled))",-0.171277,-0.188636,-0.194444,0,80,unavailable,3.6,4.3,4.9,"parathyroid gland: 4.3 nTPM (protected, limit 3); retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083817,ZNF416,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9355% (minimum 95%, Missing); adrenal gland: 69.5652% (minimum 99%, Missing); amygdala: 81.3559% (minimum 99%, Missing); basal ganglia: 78.6885% (minimum 99%, Missing); bone marrow: 54.5455% (minimum 99%, Missing); cerebellum: 71.6418% (minimum 99%, Missing); cerebral cortex: 76.1905% (minimum 99%, Missing); choroid plexus: 75.5906% (minimum 99%, Missing); colon: 71.6418% (minimum 97%, Missing); duodenum: 67.6056% (minimum 99%, Missing); esophagus: 67.1329% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); hippocampal formation: 78.6885% (minimum 99%, Missing); hypothalamus: 79.3388% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 65.3061% (minimum 99%, Missing); lung: 65.3061% (minimum 99%, Missing); lymph node: 58.1818% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 55.1724% (minimum 99%, Missing); parathyroid gland: 60.7595% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 69.0647% (minimum 97%, Missing); retina: 53.0387% (minimum 99%, Missing); salivary gland: 65.7534% (minimum 97%, Missing); skeletal muscle: 72.1805% (minimum 99%, Missing); skin: 59.2593% (minimum 95%, Missing); small intestine: 64.8649% (minimum 99%, Missing); smooth muscle: 65.7534% (minimum 99%, Missing); spinal cord: 76.8000% (minimum 99%, Missing); spleen: 54.5455% (minimum 95%, Missing); stomach: 57.4850% (minimum 97%, Missing); thymus: 55.4913% (minimum 95%, Missing); thyroid gland: 57.4850% (minimum 95%, Missing); tongue: 71.6418% (minimum 97%, Missing); urinary bladder: 69.0647% (minimum 97%, Missing)",-0.404545,-0.39515,-0.459613,0,80,unavailable,8.5,7.1,8,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); spleen: 8 nTPM (manageable, limit 5); pancreas: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); thyroid gland: 7.1 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 2); lymph node: 6.9 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); smooth muscle: 5 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); urinary bladder: 4.3 nTPM (protected, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); cerebellum: 3.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083844,ZNF264,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9355% (minimum 65%, Missing); adrenal gland: 69.5652% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 71.6418% (minimum 75%, Missing); duodenum: 67.6056% (minimum 75%, Missing); esophagus: 67.1329% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 65.3061% (minimum 75%, Missing); lung: 65.3061% (minimum 75%, Missing); lymph node: 58.1818% (minimum 70%, Missing); pancreas: 55.1724% (minimum 75%, Missing); parathyroid gland: 60.7595% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 69.0647% (minimum 70%, Missing); retina: 53.0387% (minimum 75%, Missing); salivary gland: 65.7534% (minimum 70%, Missing); skeletal muscle: 72.1805% (minimum 75%, Missing); skin: 59.2593% (minimum 65%, Missing); small intestine: 64.8649% (minimum 75%, Missing); smooth muscle: 65.7534% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 57.4850% (minimum 70%, Missing); thymus: 55.4913% (minimum 65%, Missing); thyroid gland: 57.4850% (minimum 65%, Missing); urinary bladder: 69.0647% (minimum 70%, Missing)",-0.104545,-0.12515,-0.219613,0,80,unavailable,8.5,7.1,8,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); spleen: 8 nTPM (manageable, limit 5); pancreas: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); thyroid gland: 7.1 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 2); lymph node: 6.9 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); smooth muscle: 5 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); urinary bladder: 4.3 nTPM (protected, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); cerebellum: 3.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083844,ZNF264,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9355% (minimum 65%, Missing); adrenal gland: 69.5652% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 71.6418% (minimum 75%, Missing); duodenum: 67.6056% (minimum 75%, Missing); esophagus: 67.1329% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 65.3061% (minimum 75%, Missing); lung: 65.3061% (minimum 75%, Missing); lymph node: 58.1818% (minimum 70%, Missing); pancreas: 55.1724% (minimum 75%, Missing); parathyroid gland: 60.7595% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 69.0647% (minimum 70%, Missing); retina: 53.0387% (minimum 75%, Missing); salivary gland: 65.7534% (minimum 70%, Missing); skeletal muscle: 72.1805% (minimum 75%, Missing); skin: 59.2593% (minimum 65%, Missing); small intestine: 64.8649% (minimum 75%, Missing); smooth muscle: 65.7534% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 57.4850% (minimum 70%, Missing); thymus: 55.4913% (minimum 65%, Missing); thyroid gland: 57.4850% (minimum 65%, Missing); urinary bladder: 69.0647% (minimum 70%, Missing)",-0.104545,-0.12515,-0.219613,0,80,unavailable,8.5,7.1,8,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); spleen: 8 nTPM (manageable, limit 5); pancreas: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); thyroid gland: 7.1 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 3); lymph node: 6.9 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); smooth muscle: 5 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); urinary bladder: 4.3 nTPM (protected, limit 3); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); cerebellum: 3.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083844,ZNF264,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9355% (minimum 65%, Missing); adrenal gland: 69.5652% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 71.6418% (minimum 75%, Missing); duodenum: 67.6056% (minimum 75%, Missing); esophagus: 67.1329% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 65.3061% (minimum 75%, Missing); lung: 65.3061% (minimum 75%, Missing); lymph node: 58.1818% (minimum 70%, Missing); pancreas: 55.1724% (minimum 75%, Missing); parathyroid gland: 60.7595% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 69.0647% (minimum 70%, Missing); retina: 53.0387% (minimum 75%, Missing); salivary gland: 65.7534% (minimum 70%, Missing); skeletal muscle: 72.1805% (minimum 75%, Missing); skin: 59.2593% (minimum 65%, Missing); small intestine: 64.8649% (minimum 75%, Missing); smooth muscle: 65.7534% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 57.4850% (minimum 70%, Missing); thymus: 55.4913% (minimum 65%, Missing); thyroid gland: 57.4850% (minimum 65%, Missing); urinary bladder: 69.0647% (minimum 70%, Missing)",-0.104545,-0.12515,-0.219613,0,80,unavailable,8.5,7.1,8,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); spleen: 8 nTPM (manageable, limit 5); pancreas: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); thyroid gland: 7.1 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 3); lymph node: 6.9 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); smooth muscle: 5 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); urinary bladder: 4.3 nTPM (protected, limit 3); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); cerebellum: 3.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083844,ZNF264,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9355% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 69.5652% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 54.5455% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 71.6418% (minimum 75%, Baseline (adaptation disabled)); duodenum: 67.6056% (minimum 75%, Baseline (adaptation disabled)); esophagus: 67.1329% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 65.3061% (minimum 75%, Baseline (adaptation disabled)); lung: 65.3061% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.1818% (minimum 70%, Baseline (adaptation disabled)); pancreas: 55.1724% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.7595% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.0647% (minimum 70%, Baseline (adaptation disabled)); retina: 53.0387% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.7534% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 72.1805% (minimum 75%, Baseline (adaptation disabled)); skin: 59.2593% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.8649% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.7534% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.5455% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.4850% (minimum 70%, Baseline (adaptation disabled)); thymus: 55.4913% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.4850% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 69.0647% (minimum 70%, Baseline (adaptation disabled))",-0.104545,-0.12515,-0.219613,0,80,unavailable,8.5,7.1,8,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); spleen: 8 nTPM (manageable, limit 5); pancreas: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); thyroid gland: 7.1 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 3); lymph node: 6.9 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); smooth muscle: 5 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); urinary bladder: 4.3 nTPM (protected, limit 3); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); cerebellum: 3.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000083844,ZNF264,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 92.0393% (minimum 99%, Missing); amygdala: 96.2487% (minimum 99%, Missing); basal ganglia: 96.0513% (minimum 99%, Missing); bone marrow: 93.3234% (minimum 99%, Missing); cerebellum: 97.0969% (minimum 99%, Missing); cerebral cortex: 95.9037% (minimum 99%, Missing); choroid plexus: 92.8147% (minimum 99%, Missing); colon: 92.3115% (minimum 97%, Missing); duodenum: 95.6100% (minimum 99%, Missing); esophagus: 91.3659% (minimum 97%, Missing); heart muscle: 93.8847% (minimum 99%, Missing); hippocampal formation: 96.6959% (minimum 99%, Missing); hypothalamus: 96.2982% (minimum 99%, Missing); kidney: 89.6172% (minimum 99%, Missing); liver: 96.3973% (minimum 99%, Missing); lung: 94.5482% (minimum 99%, Missing); lymph node: 94.7395% (minimum 97%, Missing); midbrain: 96.3973% (minimum 99%, Missing); pancreas: 92.8147% (minimum 99%, Missing); parathyroid gland: 79.4992% (minimum 97%, Missing); pituitary gland: 93.8847% (minimum 99%, Missing); rectum: 94.4052% (minimum 97%, Missing); retina: 92.2206% (minimum 99%, Missing); salivary gland: 90.0914% (minimum 97%, Missing); skeletal muscle: 96.4967% (minimum 99%, Missing); skin: 90.3958% (minimum 95%, Missing); small intestine: 95.1244% (minimum 99%, Missing); smooth muscle: 92.9990% (minimum 99%, Uncertain); spinal cord: 96.4470% (minimum 99%, Missing); stomach: 94.2627% (minimum 97%, Missing); thymus: 92.5395% (minimum 95%, Missing); thyroid gland: 87.1163% (minimum 95%, Missing); tongue: 96.7459% (minimum 97%, Missing); urinary bladder: 92.8607% (minimum 97%, Missing)",-0.0788372,-0.175008,-0.0938278,0,2,partial,21.7,48.3,27.7,"parathyroid gland: 48.3 nTPM (protected, limit 2); thyroid gland: 27.7 nTPM (manageable, limit 5); kidney: 21.7 nTPM (vital, limit 1); salivary gland: 20.6 nTPM (protected, limit 2); skin: 19.9 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 2); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 2); thymus: 15.1 nTPM (manageable, limit 5); choroid plexus: 14.5 nTPM (vital, limit 1); pancreas: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 2); smooth muscle: 14.1 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 2); rectum: 11.1 nTPM (protected, limit 2); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 2); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (manageable, limit 5); spleen: 8.3 nTPM (manageable, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000084693,AGBL5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.221163,0.0949915,0.146172,0,2,partial,21.7,48.3,27.7,"parathyroid gland: 48.3 nTPM (protected, limit 2); thyroid gland: 27.7 nTPM (manageable, limit 5); kidney: 21.7 nTPM (vital, limit 1); salivary gland: 20.6 nTPM (protected, limit 2); skin: 19.9 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 2); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 2); thymus: 15.1 nTPM (manageable, limit 5); choroid plexus: 14.5 nTPM (vital, limit 1); pancreas: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 2); smooth muscle: 14.1 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 2); rectum: 11.1 nTPM (protected, limit 2); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 2); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (manageable, limit 5); spleen: 8.3 nTPM (manageable, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000084693,AGBL5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.221163,0.0949915,0.146172,0,2,partial,21.7,48.3,27.7,"parathyroid gland: 48.3 nTPM (protected, limit 3); thyroid gland: 27.7 nTPM (manageable, limit 5); kidney: 21.7 nTPM (vital, limit 1); salivary gland: 20.6 nTPM (protected, limit 3); skin: 19.9 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 3); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 3); thymus: 15.1 nTPM (manageable, limit 5); choroid plexus: 14.5 nTPM (vital, limit 1); pancreas: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 3); smooth muscle: 14.1 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 3); rectum: 11.1 nTPM (protected, limit 3); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 3); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (manageable, limit 5); spleen: 8.3 nTPM (manageable, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000084693,AGBL5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.221163,0.0949915,0.146172,0,2,partial,21.7,48.3,27.7,"parathyroid gland: 48.3 nTPM (protected, limit 3); thyroid gland: 27.7 nTPM (manageable, limit 5); kidney: 21.7 nTPM (vital, limit 1); salivary gland: 20.6 nTPM (protected, limit 3); skin: 19.9 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 3); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 3); thymus: 15.1 nTPM (manageable, limit 5); choroid plexus: 14.5 nTPM (vital, limit 1); pancreas: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 3); smooth muscle: 14.1 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 3); rectum: 11.1 nTPM (protected, limit 3); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 3); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (manageable, limit 5); spleen: 8.3 nTPM (manageable, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000084693,AGBL5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.221163,0.0949915,0.146172,0,2,partial,21.7,48.3,27.7,"parathyroid gland: 48.3 nTPM (protected, limit 3); thyroid gland: 27.7 nTPM (manageable, limit 5); kidney: 21.7 nTPM (vital, limit 1); salivary gland: 20.6 nTPM (protected, limit 3); skin: 19.9 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 3); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 3); thymus: 15.1 nTPM (manageable, limit 5); choroid plexus: 14.5 nTPM (vital, limit 1); pancreas: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 3); smooth muscle: 14.1 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 3); rectum: 11.1 nTPM (protected, limit 3); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 3); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (manageable, limit 5); spleen: 8.3 nTPM (manageable, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000084693,AGBL5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.5926% (minimum 95%, Missing); adrenal gland: 89.2857% (minimum 99%, Missing); amygdala: 98.0392% (minimum 99%, Missing); basal ganglia: 98.0392% (minimum 99%, Missing); bone marrow: 14.8810% (minimum 99%, Missing); cerebellum: 89.2857% (minimum 99%, Missing); cerebral cortex: 94.3396% (minimum 99%, Missing); colon: 60.2410% (minimum 97%, Missing); duodenum: 75.7576% (minimum 99%, Missing); esophagus: 64.9351% (minimum 97%, Missing); heart muscle: 96.1538% (minimum 99%, Missing); hippocampal formation: 98.0392% (minimum 99%, Missing); hypothalamus: 96.1538% (minimum 99%, Missing); kidney: 90.9091% (minimum 99%, Missing); liver: 89.2857% (minimum 99%, Missing); lung: 89.2857% (minimum 99%, Missing); lymph node: 43.4783% (minimum 97%, Missing); midbrain: 98.0392% (minimum 99%, Missing); pancreas: 94.3396% (minimum 99%, Missing); parathyroid gland: 96.1538% (minimum 97%, Missing); pituitary gland: 94.3396% (minimum 99%, Missing); rectum: 56.1798% (minimum 97%, Missing); retina: 83.3333% (minimum 99%, Missing); salivary gland: 89.2857% (minimum 95%, Approved); skeletal muscle: 90.9091% (minimum 99%, Missing); skin: 72.4638% (minimum 95%, Missing); small intestine: 68.4932% (minimum 99%, Missing); smooth muscle: 84.7458% (minimum 99%, Missing); spinal cord: 96.1538% (minimum 99%, Missing); spleen: 72.4638% (minimum 90%, Approved); stomach: 83.3333% (minimum 97%, Missing); thymus: 30.6748% (minimum 95%, Missing); thyroid gland: 94.3396% (minimum 95%, Missing); urinary bladder: 84.7458% (minimum 97%, Missing)",-0.643252,-0.535217,-0.84119,0,5,partial,28.6,6.5,11.3,"bone marrow: 28.6 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); lymph node: 6.5 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); esophagus: 2.7 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000085840,ORC1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 14.8810% (minimum 75%, Missing); colon: 60.2410% (minimum 70%, Missing); esophagus: 64.9351% (minimum 70%, Missing); lymph node: 43.4783% (minimum 70%, Missing); rectum: 56.1798% (minimum 70%, Missing); small intestine: 68.4932% (minimum 75%, Missing); thymus: 30.6748% (minimum 65%, Missing)",-0.343252,-0.265217,-0.60119,0,5,partial,28.6,6.5,11.3,"bone marrow: 28.6 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); lymph node: 6.5 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); esophagus: 2.7 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000085840,ORC1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 14.8810% (minimum 75%, Missing); colon: 60.2410% (minimum 70%, Missing); esophagus: 64.9351% (minimum 70%, Missing); lymph node: 43.4783% (minimum 70%, Missing); rectum: 56.1798% (minimum 70%, Missing); small intestine: 68.4932% (minimum 75%, Missing); thymus: 30.6748% (minimum 65%, Missing)",-0.343252,-0.265217,-0.60119,0,5,partial,28.6,6.5,11.3,"bone marrow: 28.6 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); lymph node: 6.5 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000085840,ORC1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 14.8810% (minimum 75%, Missing); colon: 60.2410% (minimum 70%, Missing); esophagus: 64.9351% (minimum 70%, Missing); lymph node: 43.4783% (minimum 70%, Missing); rectum: 56.1798% (minimum 70%, Missing); small intestine: 68.4932% (minimum 75%, Missing); thymus: 30.6748% (minimum 65%, Missing)",-0.343252,-0.265217,-0.60119,0,5,partial,28.6,6.5,11.3,"bone marrow: 28.6 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); lymph node: 6.5 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000085840,ORC1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 14.8810% (minimum 75%, Baseline (adaptation disabled)); colon: 60.2410% (minimum 70%, Baseline (adaptation disabled)); esophagus: 64.9351% (minimum 70%, Baseline (adaptation disabled)); lymph node: 43.4783% (minimum 70%, Baseline (adaptation disabled)); rectum: 56.1798% (minimum 70%, Baseline (adaptation disabled)); small intestine: 68.4932% (minimum 75%, Baseline (adaptation disabled)); thymus: 30.6748% (minimum 65%, Baseline (adaptation disabled))",-0.343252,-0.265217,-0.60119,0,5,partial,28.6,6.5,11.3,"bone marrow: 28.6 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); lymph node: 6.5 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000085840,ORC1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.5975% (minimum 99%, Missing); amygdala: 92.6829% (minimum 99%, Missing); basal ganglia: 80.4233% (minimum 99%, Missing); bone marrow: 63.8655% (minimum 99%, Missing); cerebellum: 85.3933% (minimum 99%, Missing); cerebral cortex: 88.8889% (minimum 99%, Missing); choroid plexus: 96.8153% (minimum 99%, Missing); colon: 83.0601% (minimum 97%, Missing); duodenum: 88.8889% (minimum 99%, Missing); esophagus: 74.5098% (minimum 97%, Missing); heart muscle: 95.5975% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 92.1212% (minimum 99%, Missing); kidney: 91.5663% (minimum 99%, Missing); liver: 96.8153% (minimum 99%, Missing); lung: 93.2515% (minimum 99%, Missing); lymph node: 73.7864% (minimum 97%, Missing); midbrain: 89.4118% (minimum 99%, Missing); pancreas: 96.8153% (minimum 99%, Missing); pituitary gland: 97.4359% (minimum 99%, Missing); rectum: 77.1574% (minimum 97%, Missing); retina: 97.4359% (minimum 99%, Missing); salivary gland: 94.4099% (minimum 97%, Missing); skeletal muscle: 93.2515% (minimum 99%, Missing); skin: 87.3563% (minimum 95%, Missing); small intestine: 84.9162% (minimum 99%, Missing); smooth muscle: 89.9408% (minimum 99%, Missing); spinal cord: 81.2834% (minimum 99%, Missing); spleen: 84.9162% (minimum 95%, Missing); stomach: 91.0180% (minimum 97%, Missing); thymus: 50.3311% (minimum 95%, Missing); thyroid gland: 89.4118% (minimum 95%, Missing); urinary bladder: 95.0000% (minimum 97%, Missing)",-0.446689,-0.232136,-0.351345,0,3,partial,8.6,5.4,15,"thymus: 15 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); esophagus: 5.2 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000085999,RAD54L,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.8655% (minimum 75%, Missing); thymus: 50.3311% (minimum 65%, Missing)",-0.146689,0.0378641,-0.111345,0,3,partial,8.6,5.4,15,"thymus: 15 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); esophagus: 5.2 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000085999,RAD54L,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.8655% (minimum 75%, Missing); thymus: 50.3311% (minimum 65%, Missing)",-0.146689,0.0378641,-0.111345,0,3,partial,8.6,5.4,15,"thymus: 15 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); esophagus: 5.2 nTPM (protected, limit 3); rectum: 4.5 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000085999,RAD54L,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.8655% (minimum 75%, Missing); thymus: 50.3311% (minimum 65%, Missing)",-0.146689,0.0378641,-0.111345,0,3,partial,8.6,5.4,15,"thymus: 15 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); esophagus: 5.2 nTPM (protected, limit 3); rectum: 4.5 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000085999,RAD54L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.8655% (minimum 75%, Baseline (adaptation disabled)); thymus: 50.3311% (minimum 65%, Baseline (adaptation disabled))",-0.146689,0.0378641,-0.111345,0,3,partial,8.6,5.4,15,"thymus: 15 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); esophagus: 5.2 nTPM (protected, limit 3); rectum: 4.5 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000085999,RAD54L,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3003% (minimum 95%, Missing); adrenal gland: 70.2703% (minimum 99%, Missing); amygdala: 73.4982% (minimum 99%, Missing); basal ganglia: 73.2394% (minimum 99%, Missing); bone marrow: 76.1905% (minimum 99%, Missing); cerebellum: 78.4906% (minimum 99%, Missing); cerebral cortex: 70.9898% (minimum 99%, Missing); choroid plexus: 67.5325% (minimum 99%, Missing); colon: 70.0337% (minimum 97%, Missing); duodenum: 75.6364% (minimum 99%, Missing); esophagus: 64.1975% (minimum 95%, Approved); heart muscle: 59.4286% (minimum 99%, Missing); hippocampal formation: 70.5085% (minimum 99%, Missing); hypothalamus: 73.2394% (minimum 99%, Missing); kidney: 64.3963% (minimum 99%, Missing); liver: 65.2038% (minimum 99%, Missing); lung: 73.4982% (minimum 99%, Missing); lymph node: 67.3139% (minimum 97%, Missing); midbrain: 70.0337% (minimum 99%, Missing); pancreas: 71.2329% (minimum 99%, Missing); parathyroid gland: 61.5385% (minimum 95%, Approved); pituitary gland: 78.1955% (minimum 99%, Missing); rectum: 71.4777% (minimum 97%, Missing); retina: 77.3234% (minimum 99%, Missing); salivary gland: 71.7241% (minimum 95%, Approved); skeletal muscle: 63.2219% (minimum 98%, Approved); skin: 70.9898% (minimum 95%, Missing); small intestine: 73.2394% (minimum 99%, Missing); smooth muscle: 66.2420% (minimum 98%, Approved); spinal cord: 70.7483% (minimum 99%, Missing); spleen: 61.5385% (minimum 95%, Missing); stomach: 71.7241% (minimum 97%, Missing); thymus: 67.9739% (minimum 95%, Missing); thyroid gland: 60.4651% (minimum 95%, Missing); tongue: 59.9424% (minimum 97%, Missing); urinary bladder: 61.7211% (minimum 95%, Approved)",-0.376997,-0.370576,-0.395714,0,3,partial,14.2,13.9,15.5,"adipose tissue: 15.5 nTPM (manageable, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 2); thyroid gland: 13.6 nTPM (manageable, limit 5); spleen: 13 nTPM (manageable, limit 5); parathyroid gland: 13 nTPM (protected, limit 4); urinary bladder: 12.9 nTPM (protected, limit 4); skeletal muscle: 12.1 nTPM (vital, limit 2); esophagus: 11.6 nTPM (protected, limit 4); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 2); lymph node: 10.1 nTPM (protected, limit 2); choroid plexus: 10 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); colon: 8.9 nTPM (protected, limit 2); midbrain: 8.9 nTPM (vital, limit 1); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 2); stomach: 8.2 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 4); hypothalamus: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086200,IPO11,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3003% (minimum 65%, Missing); adrenal gland: 70.2703% (minimum 75%, Missing); amygdala: 73.4982% (minimum 75%, Missing); basal ganglia: 73.2394% (minimum 75%, Missing); cerebral cortex: 70.9898% (minimum 75%, Missing); choroid plexus: 67.5325% (minimum 75%, Missing); esophagus: 64.1975% (minimum 65%, Approved); heart muscle: 59.4286% (minimum 75%, Missing); hippocampal formation: 70.5085% (minimum 75%, Missing); hypothalamus: 73.2394% (minimum 75%, Missing); kidney: 64.3963% (minimum 75%, Missing); liver: 65.2038% (minimum 75%, Missing); lung: 73.4982% (minimum 75%, Missing); lymph node: 67.3139% (minimum 70%, Missing); midbrain: 70.0337% (minimum 75%, Missing); pancreas: 71.2329% (minimum 75%, Missing); parathyroid gland: 61.5385% (minimum 65%, Approved); skeletal muscle: 63.2219% (minimum 70%, Approved); small intestine: 73.2394% (minimum 75%, Missing); smooth muscle: 66.2420% (minimum 70%, Approved); spinal cord: 70.7483% (minimum 75%, Missing); spleen: 61.5385% (minimum 65%, Missing); thyroid gland: 60.4651% (minimum 65%, Missing); tongue: 59.9424% (minimum 70%, Missing); urinary bladder: 61.7211% (minimum 65%, Approved)",-0.0769972,-0.100576,-0.155714,0,3,partial,14.2,13.9,15.5,"adipose tissue: 15.5 nTPM (manageable, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 2); thyroid gland: 13.6 nTPM (manageable, limit 5); spleen: 13 nTPM (manageable, limit 5); parathyroid gland: 13 nTPM (protected, limit 4); urinary bladder: 12.9 nTPM (protected, limit 4); skeletal muscle: 12.1 nTPM (vital, limit 2); esophagus: 11.6 nTPM (protected, limit 4); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 2); lymph node: 10.1 nTPM (protected, limit 2); choroid plexus: 10 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); colon: 8.9 nTPM (protected, limit 2); midbrain: 8.9 nTPM (vital, limit 1); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 2); stomach: 8.2 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 4); hypothalamus: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086200,IPO11,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3003% (minimum 65%, Missing); adrenal gland: 70.2703% (minimum 75%, Missing); amygdala: 73.4982% (minimum 75%, Missing); basal ganglia: 73.2394% (minimum 75%, Missing); cerebral cortex: 70.9898% (minimum 75%, Missing); choroid plexus: 67.5325% (minimum 75%, Missing); esophagus: 64.1975% (minimum 65%, Approved); heart muscle: 59.4286% (minimum 75%, Missing); hippocampal formation: 70.5085% (minimum 75%, Missing); hypothalamus: 73.2394% (minimum 75%, Missing); kidney: 64.3963% (minimum 75%, Missing); liver: 65.2038% (minimum 75%, Missing); lung: 73.4982% (minimum 75%, Missing); lymph node: 67.3139% (minimum 70%, Missing); midbrain: 70.0337% (minimum 75%, Missing); pancreas: 71.2329% (minimum 75%, Missing); parathyroid gland: 61.5385% (minimum 65%, Approved); skeletal muscle: 63.2219% (minimum 70%, Approved); small intestine: 73.2394% (minimum 75%, Missing); smooth muscle: 66.2420% (minimum 70%, Approved); spinal cord: 70.7483% (minimum 75%, Missing); spleen: 61.5385% (minimum 65%, Missing); thyroid gland: 60.4651% (minimum 65%, Missing); tongue: 59.9424% (minimum 70%, Missing); urinary bladder: 61.7211% (minimum 65%, Approved)",-0.0769972,-0.100576,-0.155714,0,3,partial,14.2,13.9,15.5,"adipose tissue: 15.5 nTPM (manageable, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 3); thyroid gland: 13.6 nTPM (manageable, limit 5); spleen: 13 nTPM (manageable, limit 5); parathyroid gland: 13 nTPM (protected, limit 4); urinary bladder: 12.9 nTPM (protected, limit 4); skeletal muscle: 12.1 nTPM (vital, limit 2); esophagus: 11.6 nTPM (protected, limit 4); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 2); lymph node: 10.1 nTPM (protected, limit 3); choroid plexus: 10 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); colon: 8.9 nTPM (protected, limit 3); midbrain: 8.9 nTPM (vital, limit 1); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 3); stomach: 8.2 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 4); hypothalamus: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086200,IPO11,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3003% (minimum 65%, Missing); adrenal gland: 70.2703% (minimum 75%, Missing); amygdala: 73.4982% (minimum 75%, Missing); basal ganglia: 73.2394% (minimum 75%, Missing); cerebral cortex: 70.9898% (minimum 75%, Missing); choroid plexus: 67.5325% (minimum 75%, Missing); esophagus: 64.1975% (minimum 65%, Approved); heart muscle: 59.4286% (minimum 75%, Missing); hippocampal formation: 70.5085% (minimum 75%, Missing); hypothalamus: 73.2394% (minimum 75%, Missing); kidney: 64.3963% (minimum 75%, Missing); liver: 65.2038% (minimum 75%, Missing); lung: 73.4982% (minimum 75%, Missing); lymph node: 67.3139% (minimum 70%, Missing); midbrain: 70.0337% (minimum 75%, Missing); pancreas: 71.2329% (minimum 75%, Missing); parathyroid gland: 61.5385% (minimum 65%, Approved); skeletal muscle: 63.2219% (minimum 70%, Approved); small intestine: 73.2394% (minimum 75%, Missing); smooth muscle: 66.2420% (minimum 70%, Approved); spinal cord: 70.7483% (minimum 75%, Missing); spleen: 61.5385% (minimum 65%, Missing); thyroid gland: 60.4651% (minimum 65%, Missing); tongue: 59.9424% (minimum 70%, Missing); urinary bladder: 61.7211% (minimum 65%, Approved)",-0.0769972,-0.100576,-0.155714,0,3,partial,14.2,13.9,15.5,"adipose tissue: 15.5 nTPM (manageable, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 3); thyroid gland: 13.6 nTPM (manageable, limit 5); spleen: 13 nTPM (manageable, limit 5); parathyroid gland: 13 nTPM (protected, limit 4); urinary bladder: 12.9 nTPM (protected, limit 4); skeletal muscle: 12.1 nTPM (vital, limit 2); esophagus: 11.6 nTPM (protected, limit 4); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 2); lymph node: 10.1 nTPM (protected, limit 3); choroid plexus: 10 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); colon: 8.9 nTPM (protected, limit 3); midbrain: 8.9 nTPM (vital, limit 1); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 3); stomach: 8.2 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 4); hypothalamus: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086200,IPO11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3003% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 70.2703% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.4982% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.2394% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.9898% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.5325% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.1975% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.4286% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.5085% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.2394% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.3963% (minimum 75%, Baseline (adaptation disabled)); liver: 65.2038% (minimum 75%, Baseline (adaptation disabled)); lung: 73.4982% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.3139% (minimum 70%, Baseline (adaptation disabled)); midbrain: 70.0337% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.2329% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.5385% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 63.2219% (minimum 75%, Baseline (adaptation disabled)); small intestine: 73.2394% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.2420% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.7483% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.5385% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 60.4651% (minimum 65%, Baseline (adaptation disabled)); tongue: 59.9424% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.7211% (minimum 70%, Baseline (adaptation disabled))",-0.0769972,-0.100576,-0.155714,0,3,partial,14.2,13.9,15.5,"adipose tissue: 15.5 nTPM (manageable, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 3); thyroid gland: 13.6 nTPM (manageable, limit 5); spleen: 13 nTPM (manageable, limit 5); parathyroid gland: 13 nTPM (protected, limit 3); urinary bladder: 12.9 nTPM (protected, limit 3); skeletal muscle: 12.1 nTPM (vital, limit 1); esophagus: 11.6 nTPM (protected, limit 3); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 3); choroid plexus: 10 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); colon: 8.9 nTPM (protected, limit 3); midbrain: 8.9 nTPM (vital, limit 1); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 3); stomach: 8.2 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 3); hypothalamus: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086200,IPO11,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 45.2915% (minimum 95%, Enhanced); choroid plexus: 97.1154% (minimum 99%, Missing); midbrain: 98.0583% (minimum 99%, Missing); spinal cord: 96.1905% (minimum 99%, Missing)",0.0211538,0.03,-0.497085,0,1,partial,12.2,0.5,1,"bone marrow: 12.2 nTPM (vital, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086288,NME8,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 45.2915% (minimum 60%, Enhanced)",0.321154,0.3,-0.147085,0,1,partial,12.2,0.5,1,"bone marrow: 12.2 nTPM (vital, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086288,NME8,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 45.2915% (minimum 60%, Enhanced)",0.321154,0.3,-0.147085,0,1,partial,12.2,0.5,1,"bone marrow: 12.2 nTPM (vital, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086288,NME8,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 45.2915% (minimum 60%, Enhanced)",0.321154,0.3,-0.147085,0,1,partial,12.2,0.5,1,"bone marrow: 12.2 nTPM (vital, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086288,NME8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 45.2915% (minimum 75%, Baseline (adaptation disabled))",0.25991,0.25283,-0.297085,0,1,partial,12.2,0.5,1,"bone marrow: 12.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086288,NME8,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.2434% (minimum 95%, Missing); adrenal gland: 86.7021% (minimum 99%, Missing); amygdala: 87.8706% (minimum 99%, Missing); basal ganglia: 85.1175% (minimum 99%, Missing); bone marrow: 85.7895% (minimum 99%, Missing); cerebellum: 74.4292% (minimum 99%, Missing); cerebral cortex: 87.1658% (minimum 99%, Missing); choroid plexus: 82.5316% (minimum 99%, Missing); colon: 87.3995% (minimum 97%, Missing); duodenum: 75.2887% (minimum 99%, Missing); esophagus: 92.6136% (minimum 97%, Missing); heart muscle: 87.6344% (minimum 99%, Missing); hippocampal formation: 86.9333% (minimum 99%, Missing); hypothalamus: 87.6344% (minimum 99%, Missing); kidney: 81.2968% (minimum 99%, Missing); liver: 60.9346% (minimum 99%, Missing); lung: 87.8706% (minimum 99%, Missing); lymph node: 84.4560% (minimum 97%, Missing); midbrain: 89.3151% (minimum 99%, Missing); pancreas: 15.5460% (minimum 99%, Missing); parathyroid gland: 65.7258% (minimum 97%, Missing); pituitary gland: 77.9904% (minimum 99%, Missing); rectum: 90.5556% (minimum 97%, Missing); retina: 88.5870% (minimum 99%, Missing); salivary gland: 80.4938% (minimum 97%, Missing); skeletal muscle: 91.5730% (minimum 99%, Missing); skin: 92.3513% (minimum 95%, Missing); small intestine: 86.7021% (minimum 99%, Missing); smooth muscle: 87.3995% (minimum 99%, Missing); spinal cord: 86.7021% (minimum 99%, Missing); spleen: 80.8933% (minimum 95%, Missing); stomach: 42.9513% (minimum 97%, Missing); thymus: 84.6753% (minimum 95%, Missing); thyroid gland: 52.3274% (minimum 95%, Missing); tongue: 90.3047% (minimum 97%, Missing); urinary bladder: 87.1658% (minimum 97%, Missing)",-0.426726,-0.540487,-0.83454,0,3,partial,177.1,43.3,29.7,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 2); thyroid gland: 29.7 nTPM (manageable, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 2); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); salivary gland: 7.9 nTPM (protected, limit 2); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); thymus: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (manageable, limit 5); adrenal gland: 5 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086619,ERO1B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 74.4292% (minimum 75%, Missing); liver: 60.9346% (minimum 75%, Missing); pancreas: 15.5460% (minimum 75%, Missing); parathyroid gland: 65.7258% (minimum 70%, Missing); stomach: 42.9513% (minimum 70%, Missing); thyroid gland: 52.3274% (minimum 65%, Missing)",-0.126726,-0.270487,-0.59454,0,3,partial,177.1,43.3,29.7,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 2); thyroid gland: 29.7 nTPM (manageable, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 2); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); salivary gland: 7.9 nTPM (protected, limit 2); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); thymus: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (manageable, limit 5); adrenal gland: 5 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086619,ERO1B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 74.4292% (minimum 75%, Missing); liver: 60.9346% (minimum 75%, Missing); pancreas: 15.5460% (minimum 75%, Missing); parathyroid gland: 65.7258% (minimum 70%, Missing); stomach: 42.9513% (minimum 70%, Missing); thyroid gland: 52.3274% (minimum 65%, Missing)",-0.126726,-0.270487,-0.59454,0,3,partial,177.1,43.3,29.7,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 3); thyroid gland: 29.7 nTPM (manageable, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 3); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); salivary gland: 7.9 nTPM (protected, limit 3); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); thymus: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (manageable, limit 5); spinal cord: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086619,ERO1B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 74.4292% (minimum 75%, Missing); liver: 60.9346% (minimum 75%, Missing); pancreas: 15.5460% (minimum 75%, Missing); parathyroid gland: 65.7258% (minimum 70%, Missing); stomach: 42.9513% (minimum 70%, Missing); thyroid gland: 52.3274% (minimum 65%, Missing)",-0.126726,-0.270487,-0.59454,0,3,partial,177.1,43.3,29.7,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 3); thyroid gland: 29.7 nTPM (manageable, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 3); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); salivary gland: 7.9 nTPM (protected, limit 3); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); thymus: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (manageable, limit 5); spinal cord: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086619,ERO1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 74.4292% (minimum 75%, Baseline (adaptation disabled)); liver: 60.9346% (minimum 75%, Baseline (adaptation disabled)); pancreas: 15.5460% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.7258% (minimum 70%, Baseline (adaptation disabled)); stomach: 42.9513% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 52.3274% (minimum 65%, Baseline (adaptation disabled))",-0.126726,-0.270487,-0.59454,0,3,partial,177.1,43.3,29.7,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 3); thyroid gland: 29.7 nTPM (manageable, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 3); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); salivary gland: 7.9 nTPM (protected, limit 3); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); thymus: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (manageable, limit 5); spinal cord: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086619,ERO1B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5507% (minimum 99%, Missing); amygdala: 92.5170% (minimum 99%, Missing); basal ganglia: 95.1049% (minimum 99%, Missing); bone marrow: 93.1507% (minimum 99%, Missing); cerebellum: 98.5507% (minimum 99%, Missing); cerebral cortex: 79.5322% (minimum 99%, Missing); choroid plexus: 97.8417% (minimum 99%, Missing); heart muscle: 97.8417% (minimum 99%, Missing); hippocampal formation: 91.2752% (minimum 99%, Missing); hypothalamus: 91.8919% (minimum 99%, Missing); lung: 97.8417% (minimum 99%, Missing); midbrain: 88.8889% (minimum 99%, Missing); pituitary gland: 96.4539% (minimum 99%, Missing); retina: 90.6667% (minimum 99%, Missing); spinal cord: 56.9038% (minimum 99%, Missing)",0.014539,0.0155072,-0.420962,0,80,unavailable,10.3,0.2,0.5,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086717,PPEF1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 56.9038% (minimum 75%, Missing)",0.314539,0.285507,-0.180962,0,80,unavailable,10.3,0.2,0.5,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086717,PPEF1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 56.9038% (minimum 75%, Missing)",0.314539,0.285507,-0.180962,0,80,unavailable,10.3,0.2,0.5,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086717,PPEF1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 56.9038% (minimum 75%, Missing)",0.314539,0.285507,-0.180962,0,80,unavailable,10.3,0.2,0.5,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086717,PPEF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 56.9038% (minimum 75%, Baseline (adaptation disabled))",0.314539,0.285507,-0.180962,0,80,unavailable,10.3,0.2,0.5,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000086717,PPEF1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.8554% (minimum 95%, Missing); adrenal gland: 71.9457% (minimum 99%, Missing); amygdala: 76.0766% (minimum 99%, Missing); basal ganglia: 77.1845% (minimum 99%, Missing); bone marrow: 54.0816% (minimum 99%, Missing); cerebellum: 68.8312% (minimum 99%, Missing); cerebral cortex: 73.9535% (minimum 99%, Missing); choroid plexus: 57.6087% (minimum 99%, Missing); colon: 60.4563% (minimum 97%, Missing); duodenum: 50.6369% (minimum 99%, Missing); esophagus: 66.5272% (minimum 97%, Missing); heart muscle: 77.5610% (minimum 99%, Missing); hippocampal formation: 74.2991% (minimum 99%, Missing); hypothalamus: 75.3555% (minimum 99%, Missing); kidney: 58.8889% (minimum 99%, Missing); liver: 60.6870% (minimum 99%, Missing); lung: 67.9487% (minimum 99%, Missing); lymph node: 57.6087% (minimum 97%, Missing); midbrain: 73.9535% (minimum 99%, Missing); pancreas: 64.6341% (minimum 99%, Missing); parathyroid gland: 46.2209% (minimum 95%, Approved); pituitary gland: 71.6216% (minimum 99%, Missing); rectum: 57.4007% (minimum 97%, Missing); retina: 72.6027% (minimum 99%, Missing); salivary gland: 63.6000% (minimum 97%, Missing); skeletal muscle: 79.8995% (minimum 99%, Missing); skin: 65.1639% (minimum 95%, Missing); small intestine: 55.5944% (minimum 99%, Missing); smooth muscle: 72.2727% (minimum 99%, Missing); spinal cord: 74.2991% (minimum 99%, Missing); spleen: 64.1129% (minimum 95%, Missing); stomach: 65.7025% (minimum 97%, Missing); thymus: 46.9027% (minimum 95%, Missing); thyroid gland: 64.1129% (minimum 95%, Missing); tongue: 75.3555% (minimum 97%, Missing); urinary bladder: 66.5272% (minimum 97%, Missing)",-0.480973,-0.487791,-0.483631,0,5,partial,15.5,18.5,18,"parathyroid gland: 18.5 nTPM (protected, limit 4); thymus: 18 nTPM (manageable, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 2); choroid plexus: 11.7 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 2); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); liver: 10.3 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); spleen: 8.9 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); pancreas: 8.7 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); stomach: 8.3 nTPM (protected, limit 2); urinary bladder: 8 nTPM (protected, limit 2); esophagus: 8 nTPM (protected, limit 2); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000087338,GMCL1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.8554% (minimum 65%, Missing); adrenal gland: 71.9457% (minimum 75%, Missing); bone marrow: 54.0816% (minimum 75%, Missing); cerebellum: 68.8312% (minimum 75%, Missing); cerebral cortex: 73.9535% (minimum 75%, Missing); choroid plexus: 57.6087% (minimum 75%, Missing); colon: 60.4563% (minimum 70%, Missing); duodenum: 50.6369% (minimum 75%, Missing); esophagus: 66.5272% (minimum 70%, Missing); hippocampal formation: 74.2991% (minimum 75%, Missing); kidney: 58.8889% (minimum 75%, Missing); liver: 60.6870% (minimum 75%, Missing); lung: 67.9487% (minimum 75%, Missing); lymph node: 57.6087% (minimum 70%, Missing); midbrain: 73.9535% (minimum 75%, Missing); pancreas: 64.6341% (minimum 75%, Missing); parathyroid gland: 46.2209% (minimum 65%, Approved); pituitary gland: 71.6216% (minimum 75%, Missing); rectum: 57.4007% (minimum 70%, Missing); retina: 72.6027% (minimum 75%, Missing); salivary gland: 63.6000% (minimum 70%, Missing); small intestine: 55.5944% (minimum 75%, Missing); smooth muscle: 72.2727% (minimum 75%, Missing); spinal cord: 74.2991% (minimum 75%, Missing); spleen: 64.1129% (minimum 65%, Missing); stomach: 65.7025% (minimum 70%, Missing); thymus: 46.9027% (minimum 65%, Missing); thyroid gland: 64.1129% (minimum 65%, Missing); urinary bladder: 66.5272% (minimum 70%, Missing)",-0.180973,-0.187791,-0.243631,0,5,partial,15.5,18.5,18,"parathyroid gland: 18.5 nTPM (protected, limit 4); thymus: 18 nTPM (manageable, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 2); choroid plexus: 11.7 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 2); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); liver: 10.3 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); spleen: 8.9 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); pancreas: 8.7 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); stomach: 8.3 nTPM (protected, limit 2); urinary bladder: 8 nTPM (protected, limit 2); esophagus: 8 nTPM (protected, limit 2); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000087338,GMCL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.8554% (minimum 65%, Missing); adrenal gland: 71.9457% (minimum 75%, Missing); bone marrow: 54.0816% (minimum 75%, Missing); cerebellum: 68.8312% (minimum 75%, Missing); cerebral cortex: 73.9535% (minimum 75%, Missing); choroid plexus: 57.6087% (minimum 75%, Missing); colon: 60.4563% (minimum 70%, Missing); duodenum: 50.6369% (minimum 75%, Missing); esophagus: 66.5272% (minimum 70%, Missing); hippocampal formation: 74.2991% (minimum 75%, Missing); kidney: 58.8889% (minimum 75%, Missing); liver: 60.6870% (minimum 75%, Missing); lung: 67.9487% (minimum 75%, Missing); lymph node: 57.6087% (minimum 70%, Missing); midbrain: 73.9535% (minimum 75%, Missing); pancreas: 64.6341% (minimum 75%, Missing); parathyroid gland: 46.2209% (minimum 65%, Approved); pituitary gland: 71.6216% (minimum 75%, Missing); rectum: 57.4007% (minimum 70%, Missing); retina: 72.6027% (minimum 75%, Missing); salivary gland: 63.6000% (minimum 70%, Missing); small intestine: 55.5944% (minimum 75%, Missing); smooth muscle: 72.2727% (minimum 75%, Missing); spinal cord: 74.2991% (minimum 75%, Missing); spleen: 64.1129% (minimum 65%, Missing); stomach: 65.7025% (minimum 70%, Missing); thymus: 46.9027% (minimum 65%, Missing); thyroid gland: 64.1129% (minimum 65%, Missing); urinary bladder: 66.5272% (minimum 70%, Missing)",-0.180973,-0.187791,-0.243631,0,5,partial,15.5,18.5,18,"parathyroid gland: 18.5 nTPM (protected, limit 4); thymus: 18 nTPM (manageable, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 3); choroid plexus: 11.7 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 3); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 3); liver: 10.3 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); spleen: 8.9 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); pancreas: 8.7 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); stomach: 8.3 nTPM (protected, limit 3); urinary bladder: 8 nTPM (protected, limit 3); esophagus: 8 nTPM (protected, limit 3); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000087338,GMCL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.8554% (minimum 65%, Missing); adrenal gland: 71.9457% (minimum 75%, Missing); bone marrow: 54.0816% (minimum 75%, Missing); cerebellum: 68.8312% (minimum 75%, Missing); cerebral cortex: 73.9535% (minimum 75%, Missing); choroid plexus: 57.6087% (minimum 75%, Missing); colon: 60.4563% (minimum 70%, Missing); duodenum: 50.6369% (minimum 75%, Missing); esophagus: 66.5272% (minimum 70%, Missing); hippocampal formation: 74.2991% (minimum 75%, Missing); kidney: 58.8889% (minimum 75%, Missing); liver: 60.6870% (minimum 75%, Missing); lung: 67.9487% (minimum 75%, Missing); lymph node: 57.6087% (minimum 70%, Missing); midbrain: 73.9535% (minimum 75%, Missing); pancreas: 64.6341% (minimum 75%, Missing); parathyroid gland: 46.2209% (minimum 65%, Approved); pituitary gland: 71.6216% (minimum 75%, Missing); rectum: 57.4007% (minimum 70%, Missing); retina: 72.6027% (minimum 75%, Missing); salivary gland: 63.6000% (minimum 70%, Missing); small intestine: 55.5944% (minimum 75%, Missing); smooth muscle: 72.2727% (minimum 75%, Missing); spinal cord: 74.2991% (minimum 75%, Missing); spleen: 64.1129% (minimum 65%, Missing); stomach: 65.7025% (minimum 70%, Missing); thymus: 46.9027% (minimum 65%, Missing); thyroid gland: 64.1129% (minimum 65%, Missing); urinary bladder: 66.5272% (minimum 70%, Missing)",-0.180973,-0.187791,-0.243631,0,5,partial,15.5,18.5,18,"parathyroid gland: 18.5 nTPM (protected, limit 4); thymus: 18 nTPM (manageable, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 3); choroid plexus: 11.7 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 3); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 3); liver: 10.3 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); spleen: 8.9 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); pancreas: 8.7 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); stomach: 8.3 nTPM (protected, limit 3); urinary bladder: 8 nTPM (protected, limit 3); esophagus: 8 nTPM (protected, limit 3); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000087338,GMCL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.8554% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 71.9457% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 54.0816% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.8312% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.9535% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 57.6087% (minimum 75%, Baseline (adaptation disabled)); colon: 60.4563% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.6369% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.5272% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 74.2991% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.8889% (minimum 75%, Baseline (adaptation disabled)); liver: 60.6870% (minimum 75%, Baseline (adaptation disabled)); lung: 67.9487% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.6087% (minimum 70%, Baseline (adaptation disabled)); midbrain: 73.9535% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.6341% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 46.2209% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.6216% (minimum 75%, Baseline (adaptation disabled)); rectum: 57.4007% (minimum 70%, Baseline (adaptation disabled)); retina: 72.6027% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.6000% (minimum 70%, Baseline (adaptation disabled)); small intestine: 55.5944% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.2727% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.2991% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.1129% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.7025% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.9027% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 64.1129% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 66.5272% (minimum 70%, Baseline (adaptation disabled))",-0.180973,-0.237791,-0.243631,0,5,partial,15.5,18.5,18,"parathyroid gland: 18.5 nTPM (protected, limit 3); thymus: 18 nTPM (manageable, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 3); choroid plexus: 11.7 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 3); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 3); liver: 10.3 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); spleen: 8.9 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); pancreas: 8.7 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); stomach: 8.3 nTPM (protected, limit 3); urinary bladder: 8 nTPM (protected, limit 3); esophagus: 8 nTPM (protected, limit 3); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000087338,GMCL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.8571% (minimum 95%, Enhanced); amygdala: 97.0779% (minimum 99%, Missing); basal ganglia: 96.4516% (minimum 99%, Missing); bone marrow: 66.4444% (minimum 99%, Missing); choroid plexus: 98.0328% (minimum 99%, Missing); colon: 74.1935% (minimum 97%, Missing); duodenum: 72.0482% (minimum 95%, Enhanced); esophagus: 80.3763% (minimum 97%, Missing); heart muscle: 85.4286% (minimum 95%, Enhanced); hippocampal formation: 97.0779% (minimum 99%, Missing); hypothalamus: 97.0779% (minimum 99%, Missing); kidney: 93.1464% (minimum 99%, Missing); liver: 85.9195% (minimum 99%, Missing); lung: 93.4375% (minimum 99%, Missing); lymph node: 59.4433% (minimum 97%, Missing); midbrain: 95.5272% (minimum 99%, Missing); pancreas: 93.7304% (minimum 95%, Enhanced); pituitary gland: 98.0328% (minimum 99%, Missing); rectum: 70.5189% (minimum 97%, Missing); retina: 91.1585% (minimum 99%, Missing); skeletal muscle: 78.0679% (minimum 95%, Enhanced); small intestine: 76.8638% (minimum 95%, Enhanced); smooth muscle: 86.1671% (minimum 95%, Enhanced); spinal cord: 96.1415% (minimum 99%, Missing); stomach: 86.4162% (minimum 97%, Missing); thymus: 60.4040% (minimum 95%, Missing); tongue: 79.1005% (minimum 97%, Missing); urinary bladder: 91.1585% (minimum 97%, Missing)",-0.34596,-0.375567,-0.325556,0,3,partial,15.1,20.4,19.6,"lymph node: 20.4 nTPM (protected, limit 2); thymus: 19.6 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 2); duodenum: 11.6 nTPM (vital, limit 6); colon: 10.4 nTPM (protected, limit 2); small intestine: 9 nTPM (vital, limit 6); skeletal muscle: 8.4 nTPM (vital, limit 6); tongue: 7.9 nTPM (protected, limit 2); esophagus: 7.3 nTPM (protected, limit 2); liver: 4.9 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000087586,AURKA,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 66.4444% (minimum 75%, Missing); lymph node: 59.4433% (minimum 70%, Missing); thymus: 60.4040% (minimum 65%, Missing)",-0.0459596,-0.105567,-0.0855556,0,3,partial,15.1,20.4,19.6,"lymph node: 20.4 nTPM (protected, limit 2); thymus: 19.6 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 2); duodenum: 11.6 nTPM (vital, limit 6); colon: 10.4 nTPM (protected, limit 2); small intestine: 9 nTPM (vital, limit 6); skeletal muscle: 8.4 nTPM (vital, limit 6); tongue: 7.9 nTPM (protected, limit 2); esophagus: 7.3 nTPM (protected, limit 2); liver: 4.9 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000087586,AURKA,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 66.4444% (minimum 75%, Missing); lymph node: 59.4433% (minimum 70%, Missing); thymus: 60.4040% (minimum 65%, Missing)",-0.0459596,-0.105567,-0.0855556,0,3,partial,15.1,20.4,19.6,"lymph node: 20.4 nTPM (protected, limit 3); thymus: 19.6 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 3); duodenum: 11.6 nTPM (vital, limit 6); colon: 10.4 nTPM (protected, limit 3); small intestine: 9 nTPM (vital, limit 6); skeletal muscle: 8.4 nTPM (vital, limit 6); tongue: 7.9 nTPM (protected, limit 3); esophagus: 7.3 nTPM (protected, limit 3); liver: 4.9 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000087586,AURKA,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 66.4444% (minimum 75%, Missing); lymph node: 59.4433% (minimum 70%, Missing); thymus: 60.4040% (minimum 65%, Missing)",-0.0459596,-0.105567,-0.0855556,0,3,partial,15.1,20.4,19.6,"lymph node: 20.4 nTPM (protected, limit 3); thymus: 19.6 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 3); duodenum: 11.6 nTPM (vital, limit 6); colon: 10.4 nTPM (protected, limit 3); small intestine: 9 nTPM (vital, limit 6); skeletal muscle: 8.4 nTPM (vital, limit 6); tongue: 7.9 nTPM (protected, limit 3); esophagus: 7.3 nTPM (protected, limit 3); liver: 4.9 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000087586,AURKA,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 66.4444% (minimum 75%, Baseline (adaptation disabled)); duodenum: 72.0482% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.4433% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.4040% (minimum 65%, Baseline (adaptation disabled))",-0.0459596,-0.105567,-0.0855556,0,3,partial,15.1,20.4,19.6,"lymph node: 20.4 nTPM (protected, limit 3); thymus: 19.6 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 3); duodenum: 11.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 3); small intestine: 9 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 3); esophagus: 7.3 nTPM (protected, limit 3); heart muscle: 5.1 nTPM (vital, limit 1); spleen: 5.1 nTPM (manageable, limit 5); liver: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000087586,AURKA,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.5128% (minimum 99%, Missing); amygdala: 98.0263% (minimum 99%, Missing); basal ganglia: 96.7532% (minimum 99%, Missing); bone marrow: 38.6010% (minimum 99%, Missing); cerebellum: 96.4401% (minimum 99%, Missing); cerebral cortex: 94.3038% (minimum 99%, Missing); choroid plexus: 97.7049% (minimum 99%, Missing); colon: 72.5061% (minimum 97%, Missing); duodenum: 76.4103% (minimum 99%, Missing); esophagus: 69.9531% (minimum 97%, Missing); hippocampal formation: 98.0263% (minimum 99%, Missing); hypothalamus: 98.3498% (minimum 99%, Missing); kidney: 97.7049% (minimum 99%, Missing); liver: 87.9056% (minimum 99%, Missing); lung: 94.0063% (minimum 99%, Missing); lymph node: 53.5009% (minimum 97%, Missing); midbrain: 98.3498% (minimum 99%, Missing); pancreas: 98.6755% (minimum 99%, Missing); rectum: 68.3486% (minimum 97%, Missing); retina: 98.3498% (minimum 99%, Missing); skeletal muscle: 95.8199% (minimum 99%, Missing); skin: 75.6345% (minimum 95%, Missing); small intestine: 76.6067% (minimum 99%, Missing); smooth muscle: 82.0937% (minimum 99%, Missing); spinal cord: 98.3498% (minimum 99%, Missing); stomach: 83.2402% (minimum 97%, Missing); thymus: 30.3154% (minimum 95%, Missing); urinary bladder: 90.0302% (minimum 97%, Missing)",-0.646846,-0.434991,-0.60399,0,6,partial,47.4,25.9,68.5,"thymus: 68.5 nTPM (manageable, limit 5); bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 2); rectum: 13.8 nTPM (protected, limit 2); esophagus: 12.8 nTPM (protected, limit 2); colon: 11.3 nTPM (protected, limit 2); skin: 9.6 nTPM (manageable, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); liver: 4.1 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088325,TPX2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 38.6010% (minimum 75%, Missing); esophagus: 69.9531% (minimum 70%, Missing); lymph node: 53.5009% (minimum 70%, Missing); rectum: 68.3486% (minimum 70%, Missing); thymus: 30.3154% (minimum 65%, Missing)",-0.346846,-0.164991,-0.36399,0,6,partial,47.4,25.9,68.5,"thymus: 68.5 nTPM (manageable, limit 5); bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 2); rectum: 13.8 nTPM (protected, limit 2); esophagus: 12.8 nTPM (protected, limit 2); colon: 11.3 nTPM (protected, limit 2); skin: 9.6 nTPM (manageable, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); liver: 4.1 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088325,TPX2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 38.6010% (minimum 75%, Missing); esophagus: 69.9531% (minimum 70%, Missing); lymph node: 53.5009% (minimum 70%, Missing); rectum: 68.3486% (minimum 70%, Missing); thymus: 30.3154% (minimum 65%, Missing)",-0.346846,-0.164991,-0.36399,0,6,partial,47.4,25.9,68.5,"thymus: 68.5 nTPM (manageable, limit 5); bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 3); rectum: 13.8 nTPM (protected, limit 3); esophagus: 12.8 nTPM (protected, limit 3); colon: 11.3 nTPM (protected, limit 3); skin: 9.6 nTPM (manageable, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); liver: 4.1 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088325,TPX2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 38.6010% (minimum 75%, Missing); esophagus: 69.9531% (minimum 70%, Missing); lymph node: 53.5009% (minimum 70%, Missing); rectum: 68.3486% (minimum 70%, Missing); thymus: 30.3154% (minimum 65%, Missing)",-0.346846,-0.164991,-0.36399,0,6,partial,47.4,25.9,68.5,"thymus: 68.5 nTPM (manageable, limit 5); bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 3); rectum: 13.8 nTPM (protected, limit 3); esophagus: 12.8 nTPM (protected, limit 3); colon: 11.3 nTPM (protected, limit 3); skin: 9.6 nTPM (manageable, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); liver: 4.1 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088325,TPX2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 38.6010% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.9531% (minimum 70%, Baseline (adaptation disabled)); lymph node: 53.5009% (minimum 70%, Baseline (adaptation disabled)); rectum: 68.3486% (minimum 70%, Baseline (adaptation disabled)); thymus: 30.3154% (minimum 65%, Baseline (adaptation disabled))",-0.346846,-0.164991,-0.36399,0,6,partial,47.4,25.9,68.5,"thymus: 68.5 nTPM (manageable, limit 5); bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 3); rectum: 13.8 nTPM (protected, limit 3); esophagus: 12.8 nTPM (protected, limit 3); colon: 11.3 nTPM (protected, limit 3); skin: 9.6 nTPM (manageable, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); spleen: 5.1 nTPM (manageable, limit 5); liver: 4.1 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088325,TPX2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.3462% (minimum 95%, Missing); adrenal gland: 90.2307% (minimum 99%, Missing); amygdala: 83.6478% (minimum 99%, Missing); basal ganglia: 85.1472% (minimum 99%, Missing); bone marrow: 85.0384% (minimum 99%, Missing); cerebellum: 93.5302% (minimum 99%, Missing); cerebral cortex: 83.7531% (minimum 99%, Missing); choroid plexus: 37.5919% (minimum 99%, Missing); colon: 88.3134% (minimum 97%, Missing); duodenum: 91.8508% (minimum 99%, Missing); esophagus: 92.1053% (minimum 97%, Missing); heart muscle: 82.9177% (minimum 99%, Missing); hippocampal formation: 85.0384% (minimum 99%, Missing); hypothalamus: 77.3256% (minimum 99%, Missing); kidney: 71.8143% (minimum 99%, Missing); liver: 91.9779% (minimum 99%, Missing); lung: 88.7850% (minimum 99%, Missing); lymph node: 96.3768% (minimum 97%, Missing); midbrain: 78.9786% (minimum 99%, Missing); pancreas: 84.2839% (minimum 99%, Missing); parathyroid gland: 87.2703% (minimum 97%, Missing); pituitary gland: 80.6061% (minimum 99%, Missing); rectum: 89.5020% (minimum 97%, Missing); retina: 78.4198% (minimum 99%, Missing); salivary gland: 88.4309% (minimum 97%, Missing); skeletal muscle: 87.9630% (minimum 99%, Missing); skin: 89.0228% (minimum 95%, Missing); small intestine: 92.4896% (minimum 99%, Missing); smooth muscle: 93.7941% (minimum 99%, Missing); spinal cord: 87.8468% (minimum 99%, Missing); spleen: 92.3611% (minimum 95%, Missing); stomach: 87.9630% (minimum 97%, Missing); thyroid gland: 76.6129% (minimum 95%, Missing); tongue: 92.4896% (minimum 97%, Missing); urinary bladder: 90.9713% (minimum 97%, Missing)",-0.183871,-0.0972966,-0.614081,0,0,routine_complete,110.4,9.7,20.3,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (manageable, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 2); spinal cord: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); salivary gland: 8.7 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 2); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 2); adipose tissue: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 2); spleen: 5.5 nTPM (manageable, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088727,KIF9,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 37.5919% (minimum 75%, Missing); kidney: 71.8143% (minimum 75%, Missing)",0.116129,0.172703,-0.374081,0,0,routine_complete,110.4,9.7,20.3,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (manageable, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 2); spinal cord: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); salivary gland: 8.7 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 2); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 2); adipose tissue: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 2); spleen: 5.5 nTPM (manageable, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088727,KIF9,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 37.5919% (minimum 75%, Missing); kidney: 71.8143% (minimum 75%, Missing)",0.116129,0.172703,-0.374081,0,0,routine_complete,110.4,9.7,20.3,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (manageable, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 3); spinal cord: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); salivary gland: 8.7 nTPM (protected, limit 3); lung: 8.4 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 3); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 3); adipose tissue: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 3); spleen: 5.5 nTPM (manageable, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088727,KIF9,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 37.5919% (minimum 75%, Missing); kidney: 71.8143% (minimum 75%, Missing)",0.116129,0.172703,-0.374081,0,0,routine_complete,110.4,9.7,20.3,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (manageable, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 3); spinal cord: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); salivary gland: 8.7 nTPM (protected, limit 3); lung: 8.4 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 3); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 3); adipose tissue: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 3); spleen: 5.5 nTPM (manageable, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088727,KIF9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 37.5919% (minimum 75%, Baseline (adaptation disabled)); kidney: 71.8143% (minimum 75%, Baseline (adaptation disabled))",0.116129,0.172703,-0.374081,0,0,routine_complete,110.4,9.7,20.3,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (manageable, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 3); spinal cord: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); salivary gland: 8.7 nTPM (protected, limit 3); lung: 8.4 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 3); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 3); adipose tissue: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 3); spleen: 5.5 nTPM (manageable, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088727,KIF9,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.5325% (minimum 99%, Missing); heart muscle: 97.5325% (minimum 99%, Missing); kidney: 90.2644% (minimum 99%, Missing); lung: 94.4654% (minimum 99%, Missing); pancreas: 95.3046% (minimum 99%, Missing); retina: 98.1699% (minimum 99%, Missing); skeletal muscle: 93.9925% (minimum 99%, Missing); spinal cord: 98.9460% (minimum 99%, Missing)",0.00304569,0.00659298,-0.0873558,0,4,partial,8.1,5.2,12.3,"kidney: 8.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088756,ARHGAP28,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.303046,0.276593,0.152644,0,4,partial,8.1,5.2,12.3,"kidney: 8.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088756,ARHGAP28,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.303046,0.276593,0.152644,0,4,partial,8.1,5.2,12.3,"kidney: 8.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088756,ARHGAP28,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.303046,0.276593,0.152644,0,4,partial,8.1,5.2,12.3,"kidney: 8.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088756,ARHGAP28,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.209268,0.235243,0.152644,0,4,partial,8.1,5.2,12.3,"spleen: 12.3 nTPM (manageable, limit 5); kidney: 8.1 nTPM (vital, limit 1); urinary bladder: 5.2 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000088756,ARHGAP28,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.00990484,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000088782,DEFB127,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.249905,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000088782,DEFB127,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.249905,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000088782,DEFB127,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.249905,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000088782,DEFB127,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.249905,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000088782,DEFB127,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5335% (minimum 90%, Approved); adrenal gland: 88.3627% (minimum 99%, Missing); amygdala: 89.9449% (minimum 99%, Missing); basal ganglia: 89.8212% (minimum 99%, Missing); bone marrow: 66.2944% (minimum 99%, Missing); cerebellum: 89.0859% (minimum 99%, Missing); cerebral cortex: 87.7688% (minimum 99%, Missing); choroid plexus: 87.8869% (minimum 99%, Missing); colon: 87.6510% (minimum 97%, Missing); duodenum: 88.0054% (minimum 99%, Missing); esophagus: 87.6510% (minimum 97%, Missing); heart muscle: 87.5335% (minimum 99%, Missing); hippocampal formation: 90.1934% (minimum 99%, Missing); hypothalamus: 90.1934% (minimum 99%, Missing); kidney: 88.8435% (minimum 99%, Missing); liver: 87.0667% (minimum 99%, Missing); lung: 89.3297% (minimum 99%, Missing); lymph node: 86.3757% (minimum 97%, Missing); midbrain: 89.3297% (minimum 99%, Missing); pancreas: 89.2077% (minimum 99%, Missing); parathyroid gland: 86.4901% (minimum 97%, Missing); pituitary gland: 91.5849% (minimum 99%, Missing); rectum: 88.0054% (minimum 97%, Missing); retina: 88.0054% (minimum 99%, Missing); salivary gland: 88.8435% (minimum 97%, Missing); skeletal muscle: 77.3697% (minimum 99%, Missing); skin: 84.0412% (minimum 95%, Missing); small intestine: 88.3627% (minimum 99%, Missing); smooth muscle: 87.8869% (minimum 99%, Missing); spinal cord: 88.9646% (minimum 99%, Missing); spleen: 88.1242% (minimum 95%, Missing); stomach: 89.6978% (minimum 97%, Missing); thymus: 83.9332% (minimum 95%, Missing); thyroid gland: 87.0667% (minimum 95%, Missing); tongue: 82.9733% (minimum 97%, Missing); urinary bladder: 88.0054% (minimum 97%, Missing)",-0.110668,-0.140267,-0.327056,0,4,partial,33.2,13.4,12.5,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 2); thymus: 12.5 nTPM (manageable, limit 5); skin: 12.4 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 2); parathyroid gland: 10.2 nTPM (protected, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); liver: 9.7 nTPM (vital, limit 1); heart muscle: 9.3 nTPM (vital, limit 1); colon: 9.2 nTPM (protected, limit 2); esophagus: 9.2 nTPM (protected, limit 2); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); urinary bladder: 8.9 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); duodenum: 8.9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.6 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 2); kidney: 8.2 nTPM (vital, limit 1); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); stomach: 7.5 nTPM (protected, limit 2); basal ganglia: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089234,BRAP,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.2944% (minimum 75%, Missing)",0.189332,0.129733,-0.0870558,0,4,partial,33.2,13.4,12.5,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 2); thymus: 12.5 nTPM (manageable, limit 5); skin: 12.4 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 2); parathyroid gland: 10.2 nTPM (protected, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); liver: 9.7 nTPM (vital, limit 1); heart muscle: 9.3 nTPM (vital, limit 1); colon: 9.2 nTPM (protected, limit 2); esophagus: 9.2 nTPM (protected, limit 2); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); urinary bladder: 8.9 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); duodenum: 8.9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.6 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 2); kidney: 8.2 nTPM (vital, limit 1); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); stomach: 7.5 nTPM (protected, limit 2); basal ganglia: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089234,BRAP,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.2944% (minimum 75%, Missing)",0.189332,0.129733,-0.0870558,0,4,partial,33.2,13.4,12.5,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 3); thymus: 12.5 nTPM (manageable, limit 5); skin: 12.4 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 3); parathyroid gland: 10.2 nTPM (protected, limit 3); thyroid gland: 9.7 nTPM (manageable, limit 5); liver: 9.7 nTPM (vital, limit 1); heart muscle: 9.3 nTPM (vital, limit 1); colon: 9.2 nTPM (protected, limit 3); esophagus: 9.2 nTPM (protected, limit 3); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); urinary bladder: 8.9 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); duodenum: 8.9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.6 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 3); kidney: 8.2 nTPM (vital, limit 1); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); stomach: 7.5 nTPM (protected, limit 3); basal ganglia: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089234,BRAP,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.2944% (minimum 75%, Missing)",0.189332,0.129733,-0.0870558,0,4,partial,33.2,13.4,12.5,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 3); thymus: 12.5 nTPM (manageable, limit 5); skin: 12.4 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 3); parathyroid gland: 10.2 nTPM (protected, limit 3); thyroid gland: 9.7 nTPM (manageable, limit 5); liver: 9.7 nTPM (vital, limit 1); heart muscle: 9.3 nTPM (vital, limit 1); colon: 9.2 nTPM (protected, limit 3); esophagus: 9.2 nTPM (protected, limit 3); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); urinary bladder: 8.9 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); duodenum: 8.9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.6 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 3); kidney: 8.2 nTPM (vital, limit 1); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); stomach: 7.5 nTPM (protected, limit 3); basal ganglia: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089234,BRAP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.2944% (minimum 75%, Baseline (adaptation disabled))",0.189332,0.129733,-0.0870558,0,4,partial,33.2,13.4,12.5,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 3); thymus: 12.5 nTPM (manageable, limit 5); skin: 12.4 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 3); parathyroid gland: 10.2 nTPM (protected, limit 3); thyroid gland: 9.7 nTPM (manageable, limit 5); liver: 9.7 nTPM (vital, limit 1); heart muscle: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); esophagus: 9.2 nTPM (protected, limit 3); colon: 9.2 nTPM (protected, limit 3); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); rectum: 8.9 nTPM (protected, limit 3); urinary bladder: 8.9 nTPM (protected, limit 3); duodenum: 8.9 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.6 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 3); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); stomach: 7.5 nTPM (protected, limit 3); basal ganglia: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089234,BRAP,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.8153% (minimum 99%, Missing); amygdala: 97.1246% (minimum 99%, Missing); basal ganglia: 96.8153% (minimum 99%, Missing); cerebellum: 92.9664% (minimum 99%, Missing); cerebral cortex: 95.5975% (minimum 99%, Missing); colon: 96.2025% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); heart muscle: 98.3819% (minimum 99%, Missing); hippocampal formation: 97.1246% (minimum 99%, Missing); hypothalamus: 96.5079% (minimum 99%, Missing); kidney: 97.4359% (minimum 99%, Missing); liver: 98.3819% (minimum 99%, Missing); lung: 96.2025% (minimum 99%, Missing); lymph node: 95.0000% (minimum 97%, Missing); midbrain: 97.4359% (minimum 99%, Missing); pancreas: 97.7492% (minimum 99%, Missing); parathyroid gland: 96.5079% (minimum 97%, Missing); pituitary gland: 97.4359% (minimum 99%, Missing); retina: 97.1246% (minimum 99%, Missing); salivary gland: 96.8153% (minimum 97%, Missing); skeletal muscle: 98.7013% (minimum 99%, Missing); small intestine: 95.2978% (minimum 99%, Missing); smooth muscle: 98.0645% (minimum 99%, Missing); spinal cord: 96.8153% (minimum 99%, Missing); spleen: 90.7463% (minimum 95%, Missing); stomach: 96.2025% (minimum 97%, Missing); thymus: 92.1212% (minimum 95%, Missing)",-0.0425373,-0.02,-0.0603364,0,80,unavailable,2.3,1.6,3.1,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089505,CMTM1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.257463,0.25,0.179664,0,80,unavailable,2.3,1.6,3.1,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089505,CMTM1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.257463,0.25,0.179664,0,80,unavailable,2.3,1.6,3.1,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089505,CMTM1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.257463,0.25,0.179664,0,80,unavailable,2.3,1.6,3.1,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089505,CMTM1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.257463,0.25,0.179664,0,80,unavailable,2.3,1.6,3.1,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089505,CMTM1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.5274% (minimum 95%, Enhanced); amygdala: 98.9583% (minimum 99%, Missing); basal ganglia: 98.9583% (minimum 99%, Missing); bone marrow: 33.6879% (minimum 99%, Missing); choroid plexus: 96.9388% (minimum 99%, Missing); colon: 74.8031% (minimum 97%, Missing); duodenum: 71.4286% (minimum 99%, Missing); esophagus: 60.5096% (minimum 97%, Missing); hippocampal formation: 98.4456% (minimum 99%, Missing); hypothalamus: 98.9583% (minimum 99%, Missing); liver: 90.4762% (minimum 95%, Enhanced); lung: 91.3462% (minimum 95%, Enhanced); lymph node: 54.4413% (minimum 97%, Missing); midbrain: 98.4456% (minimum 99%, Missing); pituitary gland: 98.9583% (minimum 99%, Missing); rectum: 71.1610% (minimum 97%, Missing); skin: 76.9231% (minimum 95%, Missing); small intestine: 72.2433% (minimum 99%, Missing); smooth muscle: 82.2511% (minimum 95%, Enhanced); spinal cord: 97.9381% (minimum 99%, Missing); stomach: 84.0708% (minimum 97%, Missing); thymus: 32.2581% (minimum 95%, Missing); urinary bladder: 88.3721% (minimum 97%, Missing)",-0.627419,-0.425587,-0.653121,0,7,partial,37.4,15.9,39.9,"thymus: 39.9 nTPM (manageable, limit 5); bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 2); esophagus: 12.4 nTPM (protected, limit 2); rectum: 7.7 nTPM (protected, limit 2); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 2); skin: 5.7 nTPM (manageable, limit 5); stomach: 3.6 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089685,BIRC5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 33.6879% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); esophagus: 60.5096% (minimum 70%, Missing); lymph node: 54.4413% (minimum 70%, Missing); small intestine: 72.2433% (minimum 75%, Missing); thymus: 32.2581% (minimum 65%, Missing)",-0.327419,-0.155587,-0.413121,0,7,partial,37.4,15.9,39.9,"thymus: 39.9 nTPM (manageable, limit 5); bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 2); esophagus: 12.4 nTPM (protected, limit 2); rectum: 7.7 nTPM (protected, limit 2); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 2); skin: 5.7 nTPM (manageable, limit 5); stomach: 3.6 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089685,BIRC5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 33.6879% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); esophagus: 60.5096% (minimum 70%, Missing); lymph node: 54.4413% (minimum 70%, Missing); small intestine: 72.2433% (minimum 75%, Missing); thymus: 32.2581% (minimum 65%, Missing)",-0.327419,-0.155587,-0.413121,0,7,partial,37.4,15.9,39.9,"thymus: 39.9 nTPM (manageable, limit 5); bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 3); esophagus: 12.4 nTPM (protected, limit 3); rectum: 7.7 nTPM (protected, limit 3); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 3); skin: 5.7 nTPM (manageable, limit 5); stomach: 3.6 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089685,BIRC5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 33.6879% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); esophagus: 60.5096% (minimum 70%, Missing); lymph node: 54.4413% (minimum 70%, Missing); small intestine: 72.2433% (minimum 75%, Missing); thymus: 32.2581% (minimum 65%, Missing)",-0.327419,-0.155587,-0.413121,0,7,partial,37.4,15.9,39.9,"thymus: 39.9 nTPM (manageable, limit 5); bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 3); esophagus: 12.4 nTPM (protected, limit 3); rectum: 7.7 nTPM (protected, limit 3); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 3); skin: 5.7 nTPM (manageable, limit 5); stomach: 3.6 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089685,BIRC5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 33.6879% (minimum 75%, Baseline (adaptation disabled)); duodenum: 71.4286% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.5096% (minimum 70%, Baseline (adaptation disabled)); lymph node: 54.4413% (minimum 70%, Baseline (adaptation disabled)); small intestine: 72.2433% (minimum 75%, Baseline (adaptation disabled)); thymus: 32.2581% (minimum 65%, Baseline (adaptation disabled))",-0.327419,-0.155587,-0.413121,0,7,partial,37.4,15.9,39.9,"thymus: 39.9 nTPM (manageable, limit 5); bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 3); esophagus: 12.4 nTPM (protected, limit 3); rectum: 7.7 nTPM (protected, limit 3); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 3); skin: 5.7 nTPM (manageable, limit 5); spleen: 5.7 nTPM (manageable, limit 5); smooth muscle: 4.1 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); liver: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000089685,BIRC5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 8.6022% (minimum 97%, Missing); duodenum: 0.3010% (minimum 99%, Missing); rectum: 5.0633% (minimum 97%, Missing); small intestine: 0.3657% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 95%, Enhanced); stomach: 72.7273% (minimum 80%, Enhanced)",0.05,-0.919367,-0.98699,0,6,partial,530,30,0,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 2); colon: 17 nTPM (protected, limit 2)",duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),75,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; appendix / enterocytes - Microvilli; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090402,SI,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 8.6022% (minimum 70%, Missing); duodenum: 0.3010% (minimum 75%, Missing); rectum: 5.0633% (minimum 70%, Missing); small intestine: 0.3657% (minimum 75%, Missing)",0.35,-0.649367,-0.74699,0,6,partial,530,30,0,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 2); colon: 17 nTPM (protected, limit 2)",duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),75,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; appendix / enterocytes - Microvilli; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090402,SI,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 8.6022% (minimum 70%, Missing); duodenum: 0.3010% (minimum 75%, Missing); rectum: 5.0633% (minimum 70%, Missing); small intestine: 0.3657% (minimum 75%, Missing)",0.35,-0.649367,-0.74699,0,6,partial,530,30,0,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 3); colon: 17 nTPM (protected, limit 3)",duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),75,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; appendix / enterocytes - Microvilli; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090402,SI,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 8.6022% (minimum 70%, Missing); duodenum: 0.3010% (minimum 75%, Missing); rectum: 5.0633% (minimum 70%, Missing); small intestine: 0.3657% (minimum 75%, Missing)",0.35,-0.649367,-0.74699,0,6,partial,530,30,0,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 3); colon: 17 nTPM (protected, limit 3)",duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),75,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; appendix / enterocytes - Microvilli; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090402,SI,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 8.6022% (minimum 70%, Baseline (adaptation disabled)); duodenum: 0.3010% (minimum 75%, Baseline (adaptation disabled)); rectum: 5.0633% (minimum 70%, Baseline (adaptation disabled)); small intestine: 0.3657% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.35,-0.649367,-0.74699,0,6,partial,530,30,0,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 3); colon: 17 nTPM (protected, limit 3)",duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),75,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; appendix / enterocytes - Microvilli; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090402,SI,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 95%, Missing); adrenal gland: 59.3548% (minimum 99%, Missing); amygdala: 76.0331% (minimum 99%, Missing); basal ganglia: 74.7967% (minimum 99%, Missing); bone marrow: 72.4409% (minimum 99%, Missing); cerebellum: 72.4409% (minimum 99%, Missing); cerebral cortex: 58.2278% (minimum 99%, Missing); choroid plexus: 65.2482% (minimum 99%, Missing); colon: 63.0137% (minimum 97%, Missing); duodenum: 68.1481% (minimum 99%, Missing); esophagus: 59.7403% (minimum 97%, Missing); heart muscle: 68.6567% (minimum 99%, Missing); hippocampal formation: 78.6325% (minimum 99%, Missing); hypothalamus: 76.6667% (minimum 99%, Missing); kidney: 50.5495% (minimum 99%, Missing); liver: 42.5926% (minimum 99%, Missing); lung: 63.0137% (minimum 99%, Missing); lymph node: 60.5263% (minimum 95%, Approved); midbrain: 79.3103% (minimum 99%, Missing); pancreas: 64.3357% (minimum 99%, Missing); parathyroid gland: 42.2018% (minimum 97%, Missing); pituitary gland: 70.7692% (minimum 99%, Missing); rectum: 63.8889% (minimum 97%, Missing); retina: 44.2308% (minimum 99%, Missing); salivary gland: 63.0137% (minimum 97%, Missing); skeletal muscle: 80.0000% (minimum 99%, Missing); skin: 64.7887% (minimum 95%, Missing); small intestine: 64.7887% (minimum 99%, Missing); smooth muscle: 62.1622% (minimum 99%, Missing); spinal cord: 78.6325% (minimum 99%, Missing); spleen: 61.3333% (minimum 95%, Missing); stomach: 56.7901% (minimum 97%, Missing); thymus: 56.4417% (minimum 95%, Missing); thyroid gland: 46.9388% (minimum 95%, Missing); tongue: 66.1871% (minimum 97%, Missing); urinary bladder: 60.1307% (minimum 97%, Missing)",-0.480612,-0.547982,-0.564074,0,3,partial,12.4,12.6,10.4,"parathyroid gland: 12.6 nTPM (protected, limit 2); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); kidney: 9 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); stomach: 7 nTPM (protected, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); lymph node: 6 nTPM (protected, limit 4); spleen: 5.8 nTPM (manageable, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); lung: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); salivary gland: 5.4 nTPM (protected, limit 2); rectum: 5.2 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090612,ZNF268,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 65%, Missing); adrenal gland: 59.3548% (minimum 75%, Missing); basal ganglia: 74.7967% (minimum 75%, Missing); bone marrow: 72.4409% (minimum 75%, Missing); cerebellum: 72.4409% (minimum 75%, Missing); cerebral cortex: 58.2278% (minimum 75%, Missing); choroid plexus: 65.2482% (minimum 75%, Missing); colon: 63.0137% (minimum 70%, Missing); duodenum: 68.1481% (minimum 75%, Missing); esophagus: 59.7403% (minimum 70%, Missing); heart muscle: 68.6567% (minimum 75%, Missing); kidney: 50.5495% (minimum 75%, Missing); liver: 42.5926% (minimum 75%, Missing); lung: 63.0137% (minimum 75%, Missing); lymph node: 60.5263% (minimum 65%, Approved); pancreas: 64.3357% (minimum 75%, Missing); parathyroid gland: 42.2018% (minimum 70%, Missing); pituitary gland: 70.7692% (minimum 75%, Missing); rectum: 63.8889% (minimum 70%, Missing); retina: 44.2308% (minimum 75%, Missing); salivary gland: 63.0137% (minimum 70%, Missing); skin: 64.7887% (minimum 65%, Missing); small intestine: 64.7887% (minimum 75%, Missing); smooth muscle: 62.1622% (minimum 75%, Missing); spleen: 61.3333% (minimum 65%, Missing); stomach: 56.7901% (minimum 70%, Missing); thymus: 56.4417% (minimum 65%, Missing); thyroid gland: 46.9388% (minimum 65%, Missing); tongue: 66.1871% (minimum 70%, Missing); urinary bladder: 60.1307% (minimum 70%, Missing)",-0.180612,-0.277982,-0.324074,0,3,partial,12.4,12.6,10.4,"parathyroid gland: 12.6 nTPM (protected, limit 2); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); kidney: 9 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); stomach: 7 nTPM (protected, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); lymph node: 6 nTPM (protected, limit 4); spleen: 5.8 nTPM (manageable, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); lung: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); salivary gland: 5.4 nTPM (protected, limit 2); rectum: 5.2 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090612,ZNF268,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 65%, Missing); adrenal gland: 59.3548% (minimum 75%, Missing); basal ganglia: 74.7967% (minimum 75%, Missing); bone marrow: 72.4409% (minimum 75%, Missing); cerebellum: 72.4409% (minimum 75%, Missing); cerebral cortex: 58.2278% (minimum 75%, Missing); choroid plexus: 65.2482% (minimum 75%, Missing); colon: 63.0137% (minimum 70%, Missing); duodenum: 68.1481% (minimum 75%, Missing); esophagus: 59.7403% (minimum 70%, Missing); heart muscle: 68.6567% (minimum 75%, Missing); kidney: 50.5495% (minimum 75%, Missing); liver: 42.5926% (minimum 75%, Missing); lung: 63.0137% (minimum 75%, Missing); lymph node: 60.5263% (minimum 65%, Approved); pancreas: 64.3357% (minimum 75%, Missing); parathyroid gland: 42.2018% (minimum 70%, Missing); pituitary gland: 70.7692% (minimum 75%, Missing); rectum: 63.8889% (minimum 70%, Missing); retina: 44.2308% (minimum 75%, Missing); salivary gland: 63.0137% (minimum 70%, Missing); skin: 64.7887% (minimum 65%, Missing); small intestine: 64.7887% (minimum 75%, Missing); smooth muscle: 62.1622% (minimum 75%, Missing); spleen: 61.3333% (minimum 65%, Missing); stomach: 56.7901% (minimum 70%, Missing); thymus: 56.4417% (minimum 65%, Missing); thyroid gland: 46.9388% (minimum 65%, Missing); tongue: 66.1871% (minimum 70%, Missing); urinary bladder: 60.1307% (minimum 70%, Missing)",-0.180612,-0.277982,-0.324074,0,3,partial,12.4,12.6,10.4,"parathyroid gland: 12.6 nTPM (protected, limit 3); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); kidney: 9 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); stomach: 7 nTPM (protected, limit 3); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); lymph node: 6 nTPM (protected, limit 4); spleen: 5.8 nTPM (manageable, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); lung: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); salivary gland: 5.4 nTPM (protected, limit 3); rectum: 5.2 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090612,ZNF268,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 65%, Missing); adrenal gland: 59.3548% (minimum 75%, Missing); basal ganglia: 74.7967% (minimum 75%, Missing); bone marrow: 72.4409% (minimum 75%, Missing); cerebellum: 72.4409% (minimum 75%, Missing); cerebral cortex: 58.2278% (minimum 75%, Missing); choroid plexus: 65.2482% (minimum 75%, Missing); colon: 63.0137% (minimum 70%, Missing); duodenum: 68.1481% (minimum 75%, Missing); esophagus: 59.7403% (minimum 70%, Missing); heart muscle: 68.6567% (minimum 75%, Missing); kidney: 50.5495% (minimum 75%, Missing); liver: 42.5926% (minimum 75%, Missing); lung: 63.0137% (minimum 75%, Missing); lymph node: 60.5263% (minimum 65%, Approved); pancreas: 64.3357% (minimum 75%, Missing); parathyroid gland: 42.2018% (minimum 70%, Missing); pituitary gland: 70.7692% (minimum 75%, Missing); rectum: 63.8889% (minimum 70%, Missing); retina: 44.2308% (minimum 75%, Missing); salivary gland: 63.0137% (minimum 70%, Missing); skin: 64.7887% (minimum 65%, Missing); small intestine: 64.7887% (minimum 75%, Missing); smooth muscle: 62.1622% (minimum 75%, Missing); spleen: 61.3333% (minimum 65%, Missing); stomach: 56.7901% (minimum 70%, Missing); thymus: 56.4417% (minimum 65%, Missing); thyroid gland: 46.9388% (minimum 65%, Missing); tongue: 66.1871% (minimum 70%, Missing); urinary bladder: 60.1307% (minimum 70%, Missing)",-0.180612,-0.277982,-0.324074,0,3,partial,12.4,12.6,10.4,"parathyroid gland: 12.6 nTPM (protected, limit 3); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); kidney: 9 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); stomach: 7 nTPM (protected, limit 3); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); lymph node: 6 nTPM (protected, limit 4); spleen: 5.8 nTPM (manageable, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); lung: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); salivary gland: 5.4 nTPM (protected, limit 3); rectum: 5.2 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090612,ZNF268,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 59.3548% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.7967% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 72.4409% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.4409% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.2278% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 65.2482% (minimum 75%, Baseline (adaptation disabled)); colon: 63.0137% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.1481% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.7403% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.6567% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.5495% (minimum 75%, Baseline (adaptation disabled)); liver: 42.5926% (minimum 75%, Baseline (adaptation disabled)); lung: 63.0137% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.5263% (minimum 70%, Baseline (adaptation disabled)); pancreas: 64.3357% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 42.2018% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.7692% (minimum 75%, Baseline (adaptation disabled)); rectum: 63.8889% (minimum 70%, Baseline (adaptation disabled)); retina: 44.2308% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.0137% (minimum 70%, Baseline (adaptation disabled)); skin: 64.7887% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.7887% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.1622% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.3333% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.7901% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.4417% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 46.9388% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.1871% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.1307% (minimum 70%, Baseline (adaptation disabled))",-0.180612,-0.277982,-0.324074,0,3,partial,12.4,12.6,10.4,"parathyroid gland: 12.6 nTPM (protected, limit 3); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); kidney: 9 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); stomach: 7 nTPM (protected, limit 3); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); lymph node: 6 nTPM (protected, limit 3); spleen: 5.8 nTPM (manageable, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); lung: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); salivary gland: 5.4 nTPM (protected, limit 3); rectum: 5.2 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090612,ZNF268,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.0000% (minimum 95%, Missing); adrenal gland: 91.6667% (minimum 99%, Missing); amygdala: 88.0000% (minimum 99%, Missing); basal ganglia: 84.6154% (minimum 99%, Missing); bone marrow: 16.5414% (minimum 99%, Missing); cerebral cortex: 84.6154% (minimum 99%, Missing); choroid plexus: 88.0000% (minimum 99%, Missing); colon: 37.9310% (minimum 97%, Missing); duodenum: 42.3077% (minimum 99%, Missing); esophagus: 38.5965% (minimum 97%, Missing); heart muscle: 91.6667% (minimum 99%, Missing); hippocampal formation: 88.0000% (minimum 99%, Missing); hypothalamus: 81.4815% (minimum 99%, Missing); kidney: 91.6667% (minimum 99%, Missing); liver: 81.4815% (minimum 99%, Missing); lung: 81.4815% (minimum 99%, Missing); lymph node: 29.3333% (minimum 97%, Missing); midbrain: 91.6667% (minimum 99%, Missing); pancreas: 95.6522% (minimum 99%, Missing); pituitary gland: 81.4815% (minimum 99%, Missing); rectum: 33.3333% (minimum 97%, Missing); retina: 78.5714% (minimum 99%, Missing); salivary gland: 81.4815% (minimum 97%, Missing); skin: 51.1628% (minimum 95%, Missing); small intestine: 40.7407% (minimum 99%, Missing); smooth muscle: 64.7059% (minimum 98%, Approved); spinal cord: 91.6667% (minimum 99%, Missing); spleen: 48.8889% (minimum 95%, Missing); stomach: 56.4103% (minimum 97%, Missing); thymus: 15.1724% (minimum 95%, Missing); thyroid gland: 91.6667% (minimum 95%, Missing); urinary bladder: 70.9677% (minimum 97%, Missing)",-0.798276,-0.676667,-0.824586,0,3,partial,11.1,5.3,12.3,"thymus: 12.3 nTPM (manageable, limit 5); bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090889,KIF4A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 16.5414% (minimum 75%, Missing); colon: 37.9310% (minimum 70%, Missing); duodenum: 42.3077% (minimum 75%, Missing); esophagus: 38.5965% (minimum 70%, Missing); lymph node: 29.3333% (minimum 70%, Missing); rectum: 33.3333% (minimum 70%, Missing); skin: 51.1628% (minimum 65%, Missing); small intestine: 40.7407% (minimum 75%, Missing); smooth muscle: 64.7059% (minimum 70%, Approved); spleen: 48.8889% (minimum 65%, Missing); stomach: 56.4103% (minimum 70%, Missing); thymus: 15.1724% (minimum 65%, Missing)",-0.498276,-0.406667,-0.584586,0,3,partial,11.1,5.3,12.3,"thymus: 12.3 nTPM (manageable, limit 5); bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090889,KIF4A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 16.5414% (minimum 75%, Missing); colon: 37.9310% (minimum 70%, Missing); duodenum: 42.3077% (minimum 75%, Missing); esophagus: 38.5965% (minimum 70%, Missing); lymph node: 29.3333% (minimum 70%, Missing); rectum: 33.3333% (minimum 70%, Missing); skin: 51.1628% (minimum 65%, Missing); small intestine: 40.7407% (minimum 75%, Missing); smooth muscle: 64.7059% (minimum 70%, Approved); spleen: 48.8889% (minimum 65%, Missing); stomach: 56.4103% (minimum 70%, Missing); thymus: 15.1724% (minimum 65%, Missing)",-0.498276,-0.406667,-0.584586,0,3,partial,11.1,5.3,12.3,"thymus: 12.3 nTPM (manageable, limit 5); bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090889,KIF4A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 16.5414% (minimum 75%, Missing); colon: 37.9310% (minimum 70%, Missing); duodenum: 42.3077% (minimum 75%, Missing); esophagus: 38.5965% (minimum 70%, Missing); lymph node: 29.3333% (minimum 70%, Missing); rectum: 33.3333% (minimum 70%, Missing); skin: 51.1628% (minimum 65%, Missing); small intestine: 40.7407% (minimum 75%, Missing); smooth muscle: 64.7059% (minimum 70%, Approved); spleen: 48.8889% (minimum 65%, Missing); stomach: 56.4103% (minimum 70%, Missing); thymus: 15.1724% (minimum 65%, Missing)",-0.498276,-0.406667,-0.584586,0,3,partial,11.1,5.3,12.3,"thymus: 12.3 nTPM (manageable, limit 5); bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090889,KIF4A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 16.5414% (minimum 75%, Baseline (adaptation disabled)); colon: 37.9310% (minimum 70%, Baseline (adaptation disabled)); duodenum: 42.3077% (minimum 75%, Baseline (adaptation disabled)); esophagus: 38.5965% (minimum 70%, Baseline (adaptation disabled)); lymph node: 29.3333% (minimum 70%, Baseline (adaptation disabled)); rectum: 33.3333% (minimum 70%, Baseline (adaptation disabled)); skin: 51.1628% (minimum 65%, Baseline (adaptation disabled)); small intestine: 40.7407% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.7059% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.8889% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.4103% (minimum 70%, Baseline (adaptation disabled)); thymus: 15.1724% (minimum 65%, Baseline (adaptation disabled))",-0.498276,-0.406667,-0.584586,0,3,partial,11.1,5.3,12.3,"thymus: 12.3 nTPM (manageable, limit 5); bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000090889,KIF4A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.9394% (minimum 95%, Enhanced); amygdala: 81.5789% (minimum 99%, Missing); basal ganglia: 79.4872% (minimum 99%, Missing); bone marrow: 47.9381% (minimum 99%, Missing); cerebellum: 82.3009% (minimum 99%, Missing); cerebral cortex: 74.4000% (minimum 99%, Missing); choroid plexus: 97.8947% (minimum 99%, Missing); colon: 85.3211% (minimum 97%, Missing); duodenum: 86.1111% (minimum 99%, Missing); esophagus: 70.4545% (minimum 97%, Missing); heart muscle: 86.9159% (minimum 99%, Missing); hippocampal formation: 80.1724% (minimum 99%, Missing); hypothalamus: 83.7838% (minimum 99%, Missing); kidney: 95.8763% (minimum 99%, Missing); liver: 91.1765% (minimum 99%, Missing); lung: 93.9394% (minimum 99%, Missing); lymph node: 56.3636% (minimum 97%, Missing); midbrain: 86.9159% (minimum 99%, Missing); pancreas: 96.8750% (minimum 99%, Missing); parathyroid gland: 93.0000% (minimum 97%, Missing); pituitary gland: 94.8980% (minimum 99%, Missing); rectum: 83.7838% (minimum 97%, Missing); retina: 97.8947% (minimum 99%, Missing); salivary gland: 93.0000% (minimum 97%, Missing); skin: 89.4231% (minimum 95%, Missing); small intestine: 86.9159% (minimum 99%, Missing); smooth muscle: 91.1765% (minimum 95%, Enhanced); spinal cord: 91.1765% (minimum 99%, Missing); stomach: 92.0792% (minimum 97%, Missing); thymus: 60.7843% (minimum 95%, Missing)",-0.342157,-0.406364,-0.510619,0,8,partial,10.1,7.2,6,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thymus: 6 nTPM (manageable, limit 5); esophagus: 3.9 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000091651,ORC6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 47.9381% (minimum 75%, Missing); cerebral cortex: 74.4000% (minimum 75%, Missing); lymph node: 56.3636% (minimum 70%, Missing); thymus: 60.7843% (minimum 65%, Missing)",-0.0421569,-0.136364,-0.270619,0,8,partial,10.1,7.2,6,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thymus: 6 nTPM (manageable, limit 5); esophagus: 3.9 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000091651,ORC6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 47.9381% (minimum 75%, Missing); cerebral cortex: 74.4000% (minimum 75%, Missing); lymph node: 56.3636% (minimum 70%, Missing); thymus: 60.7843% (minimum 65%, Missing)",-0.0421569,-0.136364,-0.270619,0,8,partial,10.1,7.2,6,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thymus: 6 nTPM (manageable, limit 5); esophagus: 3.9 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000091651,ORC6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 47.9381% (minimum 75%, Missing); cerebral cortex: 74.4000% (minimum 75%, Missing); lymph node: 56.3636% (minimum 70%, Missing); thymus: 60.7843% (minimum 65%, Missing)",-0.0421569,-0.136364,-0.270619,0,8,partial,10.1,7.2,6,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thymus: 6 nTPM (manageable, limit 5); esophagus: 3.9 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000091651,ORC6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 47.9381% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.4000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.3636% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.7843% (minimum 65%, Baseline (adaptation disabled))",-0.0421569,-0.136364,-0.270619,0,8,partial,10.1,7.2,6,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thymus: 6 nTPM (manageable, limit 5); esophagus: 3.9 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000091651,ORC6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 24.3243% (minimum 99%, Missing)",0.0482669,0.0265398,-0.746757,0,2,partial,179.2,0.5,1.4,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092200,RPGRIP1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 24.3243% (minimum 75%, Missing)",0.348267,0.29654,-0.506757,0,2,partial,179.2,0.5,1.4,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092200,RPGRIP1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 24.3243% (minimum 75%, Missing)",0.348267,0.29654,-0.506757,0,2,partial,179.2,0.5,1.4,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092200,RPGRIP1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 24.3243% (minimum 75%, Missing)",0.348267,0.29654,-0.506757,0,2,partial,179.2,0.5,1.4,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092200,RPGRIP1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 24.3243% (minimum 75%, Baseline (adaptation disabled))",0.326271,0.291394,-0.506757,0,2,partial,179.2,0.5,1.4,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092200,RPGRIP1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.05,0.026134,0.01,0,6,partial,0.2,0.3,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092345,DAZL,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296134,0.25,0,6,partial,0.2,0.3,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092345,DAZL,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296134,0.25,0,6,partial,0.2,0.3,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092345,DAZL,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296134,0.25,0,6,partial,0.2,0.3,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092345,DAZL,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348708,0.296134,0.247419,0,6,partial,0.2,0.3,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092345,DAZL,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.8033% (minimum 95%, Missing); adrenal gland: 96.5517% (minimum 99%, Missing); amygdala: 98.2456% (minimum 99%, Missing); basal ganglia: 98.2456% (minimum 99%, Missing); bone marrow: 33.5329% (minimum 99%, Missing); cerebral cortex: 91.8033% (minimum 99%, Missing); choroid plexus: 98.2456% (minimum 99%, Missing); colon: 81.1594% (minimum 97%, Missing); duodenum: 84.8485% (minimum 99%, Missing); esophagus: 86.1538% (minimum 97%, Missing); heart muscle: 98.2456% (minimum 99%, Missing); hippocampal formation: 96.5517% (minimum 99%, Missing); hypothalamus: 98.2456% (minimum 99%, Missing); kidney: 98.2456% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); lung: 93.3333% (minimum 99%, Missing); lymph node: 53.8462% (minimum 97%, Missing); pancreas: 98.2456% (minimum 99%, Missing); parathyroid gland: 96.5517% (minimum 97%, Missing); rectum: 73.6842% (minimum 97%, Missing); retina: 45.9016% (minimum 99%, Missing); salivary gland: 96.5517% (minimum 97%, Missing); skeletal muscle: 91.8033% (minimum 99%, Missing); skin: 83.5821% (minimum 95%, Missing); small intestine: 84.8485% (minimum 99%, Missing); smooth muscle: 86.1538% (minimum 99%, Missing); spinal cord: 98.2456% (minimum 99%, Missing); spleen: 82.3529% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thymus: 42.1053% (minimum 95%, Missing); urinary bladder: 90.3226% (minimum 97%, Missing)",-0.528947,-0.431538,-0.654671,0,80,unavailable,11.1,4.8,7.7,"bone marrow: 11.1 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); retina: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092853,CLSPN,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 33.5329% (minimum 75%, Missing); lymph node: 53.8462% (minimum 70%, Missing); retina: 45.9016% (minimum 75%, Missing); thymus: 42.1053% (minimum 65%, Missing)",-0.228947,-0.161538,-0.414671,0,80,unavailable,11.1,4.8,7.7,"bone marrow: 11.1 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); retina: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092853,CLSPN,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 33.5329% (minimum 75%, Missing); lymph node: 53.8462% (minimum 70%, Missing); retina: 45.9016% (minimum 75%, Missing); thymus: 42.1053% (minimum 65%, Missing)",-0.228947,-0.161538,-0.414671,0,80,unavailable,11.1,4.8,7.7,"bone marrow: 11.1 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); retina: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092853,CLSPN,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 33.5329% (minimum 75%, Missing); lymph node: 53.8462% (minimum 70%, Missing); retina: 45.9016% (minimum 75%, Missing); thymus: 42.1053% (minimum 65%, Missing)",-0.228947,-0.161538,-0.414671,0,80,unavailable,11.1,4.8,7.7,"bone marrow: 11.1 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); retina: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092853,CLSPN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 33.5329% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.8462% (minimum 70%, Baseline (adaptation disabled)); retina: 45.9016% (minimum 75%, Baseline (adaptation disabled)); thymus: 42.1053% (minimum 65%, Baseline (adaptation disabled))",-0.228947,-0.161538,-0.414671,0,80,unavailable,11.1,4.8,7.7,"bone marrow: 11.1 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); retina: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000092853,CLSPN,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 47.4895% (minimum 99%, Missing); cerebral cortex: 98.6957% (minimum 99%, Missing); colon: 83.4559% (minimum 97%, Missing); duodenum: 86.9732% (minimum 95%, Enhanced); kidney: 98.6957% (minimum 99%, Missing); lung: 96.1864% (minimum 99%, Missing); lymph node: 67.1598% (minimum 97%, Missing); rectum: 79.6491% (minimum 80%, Enhanced); skin: 87.6448% (minimum 95%, Missing); small intestine: 88.3268% (minimum 95%, Enhanced); smooth muscle: 93.0328% (minimum 95%, Enhanced); stomach: 90.0794% (minimum 97%, Missing); thymus: 53.4118% (minimum 95%, Missing); urinary bladder: 92.2764% (minimum 97%, Missing)",-0.415882,-0.298402,-0.515105,0,7,partial,25.1,11.1,19.8,"bone marrow: 25.1 nTPM (vital, limit 1); thymus: 19.8 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibrohistiocytic cells; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000093009,CDC45,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 47.4895% (minimum 75%, Missing); lymph node: 67.1598% (minimum 70%, Missing); thymus: 53.4118% (minimum 65%, Missing)",-0.115882,-0.0284024,-0.275105,0,7,partial,25.1,11.1,19.8,"bone marrow: 25.1 nTPM (vital, limit 1); thymus: 19.8 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibrohistiocytic cells; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000093009,CDC45,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 47.4895% (minimum 75%, Missing); lymph node: 67.1598% (minimum 70%, Missing); thymus: 53.4118% (minimum 65%, Missing)",-0.115882,-0.0284024,-0.275105,0,7,partial,25.1,11.1,19.8,"bone marrow: 25.1 nTPM (vital, limit 1); thymus: 19.8 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibrohistiocytic cells; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000093009,CDC45,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 47.4895% (minimum 75%, Missing); lymph node: 67.1598% (minimum 70%, Missing); thymus: 53.4118% (minimum 65%, Missing)",-0.115882,-0.0284024,-0.275105,0,7,partial,25.1,11.1,19.8,"bone marrow: 25.1 nTPM (vital, limit 1); thymus: 19.8 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibrohistiocytic cells; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000093009,CDC45,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 47.4895% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.1598% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.4118% (minimum 65%, Baseline (adaptation disabled))",-0.115882,-0.0284024,-0.275105,0,7,partial,25.1,11.1,19.8,"bone marrow: 25.1 nTPM (vital, limit 1); thymus: 19.8 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); esophagus: 5.1 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibrohistiocytic cells; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000093009,CDC45,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.3529% (minimum 90%, Approved); adrenal gland: 84.4828% (minimum 99%, Missing); amygdala: 94.2308% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); bone marrow: 26.7030% (minimum 99%, Missing); cerebellum: 93.3333% (minimum 99%, Missing); cerebral cortex: 86.7257% (minimum 99%, Missing); choroid plexus: 93.3333% (minimum 99%, Missing); colon: 54.7486% (minimum 97%, Missing); duodenum: 57.3099% (minimum 99%, Missing); esophagus: 64.0523% (minimum 97%, Missing); heart muscle: 94.2308% (minimum 99%, Missing); hippocampal formation: 95.1456% (minimum 99%, Missing); hypothalamus: 95.1456% (minimum 99%, Missing); kidney: 95.1456% (minimum 99%, Missing); liver: 77.1654% (minimum 99%, Missing); lung: 88.2883% (minimum 99%, Missing); lymph node: 37.9845% (minimum 97%, Missing); midbrain: 97.0297% (minimum 99%, Missing); pancreas: 84.4828% (minimum 99%, Missing); parathyroid gland: 92.4528% (minimum 95%, Approved); pituitary gland: 95.1456% (minimum 99%, Missing); rectum: 53.8462% (minimum 97%, Missing); retina: 95.1456% (minimum 99%, Missing); salivary gland: 88.2883% (minimum 97%, Missing); skeletal muscle: 97.0297% (minimum 99%, Missing); skin: 78.4000% (minimum 95%, Missing); small intestine: 60.1227% (minimum 99%, Missing); smooth muscle: 73.1343% (minimum 99%, Missing); spinal cord: 97.0297% (minimum 99%, Missing); spleen: 73.1343% (minimum 95%, Missing); stomach: 73.6842% (minimum 97%, Missing); thymus: 37.6923% (minimum 95%, Missing); thyroid gland: 85.2174% (minimum 95%, Missing); tongue: 95.1456% (minimum 97%, Missing); urinary bladder: 70.0000% (minimum 97%, Missing)",-0.573077,-0.590155,-0.72297,0,1,partial,26.9,16,16.2,"bone marrow: 26.9 nTPM (vital, limit 1); thymus: 16.2 nTPM (manageable, limit 5); lymph node: 16 nTPM (protected, limit 2); rectum: 8.4 nTPM (protected, limit 2); colon: 8.1 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000094804,CDC6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 26.7030% (minimum 75%, Missing); colon: 54.7486% (minimum 70%, Missing); duodenum: 57.3099% (minimum 75%, Missing); esophagus: 64.0523% (minimum 70%, Missing); lymph node: 37.9845% (minimum 70%, Missing); rectum: 53.8462% (minimum 70%, Missing); small intestine: 60.1227% (minimum 75%, Missing); smooth muscle: 73.1343% (minimum 75%, Missing); thymus: 37.6923% (minimum 65%, Missing)",-0.273077,-0.320155,-0.48297,0,1,partial,26.9,16,16.2,"bone marrow: 26.9 nTPM (vital, limit 1); thymus: 16.2 nTPM (manageable, limit 5); lymph node: 16 nTPM (protected, limit 2); rectum: 8.4 nTPM (protected, limit 2); colon: 8.1 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000094804,CDC6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 26.7030% (minimum 75%, Missing); colon: 54.7486% (minimum 70%, Missing); duodenum: 57.3099% (minimum 75%, Missing); esophagus: 64.0523% (minimum 70%, Missing); lymph node: 37.9845% (minimum 70%, Missing); rectum: 53.8462% (minimum 70%, Missing); small intestine: 60.1227% (minimum 75%, Missing); smooth muscle: 73.1343% (minimum 75%, Missing); thymus: 37.6923% (minimum 65%, Missing)",-0.273077,-0.320155,-0.48297,0,1,partial,26.9,16,16.2,"bone marrow: 26.9 nTPM (vital, limit 1); thymus: 16.2 nTPM (manageable, limit 5); lymph node: 16 nTPM (protected, limit 3); rectum: 8.4 nTPM (protected, limit 3); colon: 8.1 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); urinary bladder: 4.2 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000094804,CDC6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 26.7030% (minimum 75%, Missing); colon: 54.7486% (minimum 70%, Missing); duodenum: 57.3099% (minimum 75%, Missing); esophagus: 64.0523% (minimum 70%, Missing); lymph node: 37.9845% (minimum 70%, Missing); rectum: 53.8462% (minimum 70%, Missing); small intestine: 60.1227% (minimum 75%, Missing); smooth muscle: 73.1343% (minimum 75%, Missing); thymus: 37.6923% (minimum 65%, Missing)",-0.273077,-0.320155,-0.48297,0,1,partial,26.9,16,16.2,"bone marrow: 26.9 nTPM (vital, limit 1); thymus: 16.2 nTPM (manageable, limit 5); lymph node: 16 nTPM (protected, limit 3); rectum: 8.4 nTPM (protected, limit 3); colon: 8.1 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); urinary bladder: 4.2 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000094804,CDC6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 26.7030% (minimum 75%, Baseline (adaptation disabled)); colon: 54.7486% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.3099% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.0523% (minimum 70%, Baseline (adaptation disabled)); lymph node: 37.9845% (minimum 70%, Baseline (adaptation disabled)); rectum: 53.8462% (minimum 70%, Baseline (adaptation disabled)); small intestine: 60.1227% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.1343% (minimum 75%, Baseline (adaptation disabled)); thymus: 37.6923% (minimum 65%, Baseline (adaptation disabled))",-0.273077,-0.320155,-0.48297,0,1,partial,26.9,16,16.2,"bone marrow: 26.9 nTPM (vital, limit 1); thymus: 16.2 nTPM (manageable, limit 5); lymph node: 16 nTPM (protected, limit 3); rectum: 8.4 nTPM (protected, limit 3); colon: 8.1 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); urinary bladder: 4.2 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000094804,CDC6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 76.0000% (minimum 95%, Missing); adrenal gland: 64.4909% (minimum 99%, Missing); amygdala: 55.8824% (minimum 99%, Missing); basal ganglia: 57.7103% (minimum 99%, Missing); bone marrow: 59.3750% (minimum 99%, Missing); cerebellum: 60.2439% (minimum 99%, Missing); cerebral cortex: 48.8142% (minimum 99%, Missing); choroid plexus: 17.6429% (minimum 99%, Missing); colon: 70.7736% (minimum 97%, Missing); duodenum: 77.1875% (minimum 99%, Missing); esophagus: 73.2938% (minimum 97%, Missing); heart muscle: 55.1339% (minimum 95%, Enhanced); hippocampal formation: 59.3750% (minimum 99%, Missing); hypothalamus: 53.4632% (minimum 99%, Missing); kidney: 59.8063% (minimum 99%, Missing); liver: 76.0000% (minimum 95%, Enhanced); lung: 72.6471% (minimum 99%, Missing); lymph node: 57.3086% (minimum 97%, Missing); midbrain: 57.8454% (minimum 99%, Missing); pancreas: 71.8023% (minimum 99%, Missing); parathyroid gland: 49.8990% (minimum 97%, Missing); pituitary gland: 56.2642% (minimum 99%, Missing); rectum: 70.1705% (minimum 97%, Missing); retina: 52.6652% (minimum 99%, Missing); salivary gland: 74.8485% (minimum 97%, Missing); skeletal muscle: 65.0000% (minimum 95%, Enhanced); skin: 59.5181% (minimum 95%, Missing); small intestine: 74.3976% (minimum 99%, Missing); smooth muscle: 70.3704% (minimum 95%, Enhanced); spinal cord: 54.8889% (minimum 99%, Missing); spleen: 70.3704% (minimum 95%, Missing); stomach: 71.1816% (minimum 97%, Missing); thymus: 44.9909% (minimum 95%, Missing); thyroid gland: 51.5658% (minimum 95%, Missing); tongue: 76.9470% (minimum 97%, Missing); urinary bladder: 78.1646% (minimum 97%, Missing)",-0.500091,-0.47101,-0.813571,0,10,partial,115.3,24.8,30.2,"choroid plexus: 115.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 2); thyroid gland: 23.2 nTPM (manageable, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 6); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 2); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 6); rectum: 10.5 nTPM (protected, limit 2); smooth muscle: 10.4 nTPM (vital, limit 6); spleen: 10.4 nTPM (manageable, limit 5); colon: 10.2 nTPM (protected, limit 2); stomach: 10 nTPM (protected, limit 2); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); small intestine: 8.5 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 6); tongue: 7.4 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Low (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / sebaceous glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000094916,CBX5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.4909% (minimum 75%, Missing); amygdala: 55.8824% (minimum 75%, Missing); basal ganglia: 57.7103% (minimum 75%, Missing); bone marrow: 59.3750% (minimum 75%, Missing); cerebellum: 60.2439% (minimum 75%, Missing); cerebral cortex: 48.8142% (minimum 75%, Missing); choroid plexus: 17.6429% (minimum 75%, Missing); heart muscle: 55.1339% (minimum 60%, Enhanced); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 53.4632% (minimum 75%, Missing); kidney: 59.8063% (minimum 75%, Missing); lung: 72.6471% (minimum 75%, Missing); lymph node: 57.3086% (minimum 70%, Missing); midbrain: 57.8454% (minimum 75%, Missing); pancreas: 71.8023% (minimum 75%, Missing); parathyroid gland: 49.8990% (minimum 70%, Missing); pituitary gland: 56.2642% (minimum 75%, Missing); retina: 52.6652% (minimum 75%, Missing); skin: 59.5181% (minimum 65%, Missing); small intestine: 74.3976% (minimum 75%, Missing); spinal cord: 54.8889% (minimum 75%, Missing); thymus: 44.9909% (minimum 65%, Missing); thyroid gland: 51.5658% (minimum 65%, Missing)",-0.200091,-0.20101,-0.573571,0,10,partial,115.3,24.8,30.2,"choroid plexus: 115.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 2); thyroid gland: 23.2 nTPM (manageable, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 6); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 2); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 6); rectum: 10.5 nTPM (protected, limit 2); smooth muscle: 10.4 nTPM (vital, limit 6); spleen: 10.4 nTPM (manageable, limit 5); colon: 10.2 nTPM (protected, limit 2); stomach: 10 nTPM (protected, limit 2); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); small intestine: 8.5 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 6); tongue: 7.4 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Low (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / sebaceous glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000094916,CBX5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.4909% (minimum 75%, Missing); amygdala: 55.8824% (minimum 75%, Missing); basal ganglia: 57.7103% (minimum 75%, Missing); bone marrow: 59.3750% (minimum 75%, Missing); cerebellum: 60.2439% (minimum 75%, Missing); cerebral cortex: 48.8142% (minimum 75%, Missing); choroid plexus: 17.6429% (minimum 75%, Missing); heart muscle: 55.1339% (minimum 60%, Enhanced); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 53.4632% (minimum 75%, Missing); kidney: 59.8063% (minimum 75%, Missing); lung: 72.6471% (minimum 75%, Missing); lymph node: 57.3086% (minimum 70%, Missing); midbrain: 57.8454% (minimum 75%, Missing); pancreas: 71.8023% (minimum 75%, Missing); parathyroid gland: 49.8990% (minimum 70%, Missing); pituitary gland: 56.2642% (minimum 75%, Missing); retina: 52.6652% (minimum 75%, Missing); skin: 59.5181% (minimum 65%, Missing); small intestine: 74.3976% (minimum 75%, Missing); spinal cord: 54.8889% (minimum 75%, Missing); thymus: 44.9909% (minimum 65%, Missing); thyroid gland: 51.5658% (minimum 65%, Missing)",-0.200091,-0.20101,-0.573571,0,10,partial,115.3,24.8,30.2,"choroid plexus: 115.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 3); thyroid gland: 23.2 nTPM (manageable, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 6); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 3); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 6); rectum: 10.5 nTPM (protected, limit 3); smooth muscle: 10.4 nTPM (vital, limit 6); spleen: 10.4 nTPM (manageable, limit 5); colon: 10.2 nTPM (protected, limit 3); stomach: 10 nTPM (protected, limit 3); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); small intestine: 8.5 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 3); adipose tissue: 7.8 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 6); tongue: 7.4 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Low (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / sebaceous glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000094916,CBX5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.4909% (minimum 75%, Missing); amygdala: 55.8824% (minimum 75%, Missing); basal ganglia: 57.7103% (minimum 75%, Missing); bone marrow: 59.3750% (minimum 75%, Missing); cerebellum: 60.2439% (minimum 75%, Missing); cerebral cortex: 48.8142% (minimum 75%, Missing); choroid plexus: 17.6429% (minimum 75%, Missing); heart muscle: 55.1339% (minimum 60%, Enhanced); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 53.4632% (minimum 75%, Missing); kidney: 59.8063% (minimum 75%, Missing); lung: 72.6471% (minimum 75%, Missing); lymph node: 57.3086% (minimum 70%, Missing); midbrain: 57.8454% (minimum 75%, Missing); pancreas: 71.8023% (minimum 75%, Missing); parathyroid gland: 49.8990% (minimum 70%, Missing); pituitary gland: 56.2642% (minimum 75%, Missing); retina: 52.6652% (minimum 75%, Missing); skin: 59.5181% (minimum 65%, Missing); small intestine: 74.3976% (minimum 75%, Missing); spinal cord: 54.8889% (minimum 75%, Missing); thymus: 44.9909% (minimum 65%, Missing); thyroid gland: 51.5658% (minimum 65%, Missing)",-0.200091,-0.20101,-0.573571,0,10,partial,115.3,24.8,30.2,"choroid plexus: 115.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 3); thyroid gland: 23.2 nTPM (manageable, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 6); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 3); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 6); rectum: 10.5 nTPM (protected, limit 3); smooth muscle: 10.4 nTPM (vital, limit 6); spleen: 10.4 nTPM (manageable, limit 5); colon: 10.2 nTPM (protected, limit 3); stomach: 10 nTPM (protected, limit 3); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); small intestine: 8.5 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 3); adipose tissue: 7.8 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 6); tongue: 7.4 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Low (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / sebaceous glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000094916,CBX5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.4909% (minimum 75%, Baseline (adaptation disabled)); amygdala: 55.8824% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 57.7103% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 59.3750% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.2439% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.8142% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 17.6429% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 55.1339% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 59.3750% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.4632% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.8063% (minimum 75%, Baseline (adaptation disabled)); lung: 72.6471% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.3086% (minimum 70%, Baseline (adaptation disabled)); midbrain: 57.8454% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.8023% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.8990% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 56.2642% (minimum 75%, Baseline (adaptation disabled)); retina: 52.6652% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 65.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 59.5181% (minimum 65%, Baseline (adaptation disabled)); small intestine: 74.3976% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.3704% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 54.8889% (minimum 75%, Baseline (adaptation disabled)); thymus: 44.9909% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 51.5658% (minimum 65%, Baseline (adaptation disabled))",-0.200091,-0.20101,-0.573571,0,10,partial,115.3,24.8,30.2,"choroid plexus: 115.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 3); thyroid gland: 23.2 nTPM (manageable, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 3); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 3); smooth muscle: 10.4 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); colon: 10.2 nTPM (protected, limit 3); stomach: 10 nTPM (protected, limit 3); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); small intestine: 8.5 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 3); adipose tissue: 7.8 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Low (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / sebaceous glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000094916,CBX5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 90.4762% (minimum 95%, Enhanced)",0.037013,0.00435897,-0.0452381,0,1,partial,1.6,0.4,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095627,TDRD1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.337013,0.274359,0.243464,0,1,partial,1.6,0.4,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095627,TDRD1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.337013,0.274359,0.243464,0,1,partial,1.6,0.4,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095627,TDRD1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.337013,0.274359,0.243464,0,1,partial,1.6,0.4,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095627,TDRD1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.318153,0.274359,0.154762,0,1,partial,1.6,0.4,0.5,"kidney: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095627,TDRD1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 98.0392% (minimum 99%, Missing); amygdala: 98.0392% (minimum 99%, Missing); basal ganglia: 73.5294% (minimum 99%, Missing); choroid plexus: 98.0392% (minimum 99%, Missing); esophagus: 94.3396% (minimum 97%, Missing); hippocampal formation: 98.0392% (minimum 99%, Missing); hypothalamus: 90.9091% (minimum 99%, Missing); kidney: 94.3396% (minimum 99%, Missing); pancreas: 87.7193% (minimum 95%, Enhanced); pituitary gland: 92.5926% (minimum 99%, Missing); retina: 25.0000% (minimum 99%, Missing); skin: 87.7193% (minimum 95%, Missing); stomach: 96.1538% (minimum 97%, Missing)",-0.072807,-0.0266038,-0.74,0,3,partial,15,0.3,0.7,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),61,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095777,MYO3A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.5294% (minimum 75%, Missing); retina: 25.0000% (minimum 75%, Missing)",0.227193,0.243396,-0.5,0,3,partial,15,0.3,0.7,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),61,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095777,MYO3A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.5294% (minimum 75%, Missing); retina: 25.0000% (minimum 75%, Missing)",0.227193,0.243396,-0.5,0,3,partial,15,0.3,0.7,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),61,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095777,MYO3A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.5294% (minimum 75%, Missing); retina: 25.0000% (minimum 75%, Missing)",0.227193,0.243396,-0.5,0,3,partial,15,0.3,0.7,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),61,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095777,MYO3A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.5294% (minimum 75%, Baseline (adaptation disabled)); retina: 25.0000% (minimum 75%, Baseline (adaptation disabled))",0.227193,0.243396,-0.5,0,3,partial,15,0.3,0.7,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),61,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095777,MYO3A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.6866% (minimum 99%, Missing); amygdala: 84.0430% (minimum 99%, Missing); basal ganglia: 84.6026% (minimum 99%, Missing); bone marrow: 90.4359% (minimum 99%, Missing); cerebellum: 93.5143% (minimum 99%, Missing); cerebral cortex: 83.8005% (minimum 95%, Enhanced); choroid plexus: 78.4942% (minimum 99%, Missing); colon: 89.7176% (minimum 97%, Missing); duodenum: 95.9868% (minimum 99%, Missing); heart muscle: 80.9960% (minimum 99%, Missing); hippocampal formation: 85.5280% (minimum 99%, Missing); hypothalamus: 83.1833% (minimum 99%, Missing); kidney: 78.3128% (minimum 99%, Missing); liver: 77.8331% (minimum 99%, Missing); lung: 87.4785% (minimum 99%, Missing); midbrain: 85.4202% (minimum 99%, Missing); pancreas: 93.0861% (minimum 99%, Missing); parathyroid gland: 89.8762% (minimum 97%, Missing); pituitary gland: 77.8927% (minimum 99%, Missing); rectum: 93.9898% (minimum 97%, Missing); retina: 90.3556% (minimum 99%, Missing); salivary gland: 93.9030% (minimum 97%, Missing); skeletal muscle: 87.8565% (minimum 99%, Missing); small intestine: 93.0861% (minimum 99%, Missing); smooth muscle: 89.6780% (minimum 95%, Enhanced); spinal cord: 85.2768% (minimum 99%, Missing); stomach: 91.1659% (minimum 97%, Missing); thymus: 87.7428% (minimum 95%, Missing); tongue: 87.3657% (minimum 97%, Missing); urinary bladder: 77.8033% (minimum 80%, Enhanced)",-0.0725723,-0.0963429,-0.383134,0,18,partial,131.7,58,52.6,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 12); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (manageable, limit 30); heart muscle: 47.7 nTPM (vital, limit 1); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 6); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 2); lung: 29.1 nTPM (vital, limit 1); thymus: 28.4 nTPM (manageable, limit 5); skeletal muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 23.4 nTPM (vital, limit 6); colon: 23.3 nTPM (protected, limit 2); parathyroid gland: 22.9 nTPM (protected, limit 2); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 2); lymph node: 17 nTPM (protected, limit 12); esophagus: 16.8 nTPM (protected, limit 12); pancreas: 15.1 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); salivary gland: 13.2 nTPM (protected, limit 2); rectum: 13 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / extracellular matrix: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / extracellular matrix; skin 1 / fibrohistiocytic cells; skin 2 / extracellular matrix; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095794,CREM,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.6866% (minimum 75%, Missing)",0.227428,0.173657,-0.143134,0,18,partial,131.7,58,52.6,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 12); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (manageable, limit 30); heart muscle: 47.7 nTPM (vital, limit 1); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 6); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 2); lung: 29.1 nTPM (vital, limit 1); thymus: 28.4 nTPM (manageable, limit 5); skeletal muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 23.4 nTPM (vital, limit 6); colon: 23.3 nTPM (protected, limit 2); parathyroid gland: 22.9 nTPM (protected, limit 2); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 2); lymph node: 17 nTPM (protected, limit 12); esophagus: 16.8 nTPM (protected, limit 12); pancreas: 15.1 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); salivary gland: 13.2 nTPM (protected, limit 2); rectum: 13 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / extracellular matrix: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / extracellular matrix; skin 1 / fibrohistiocytic cells; skin 2 / extracellular matrix; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095794,CREM,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.6866% (minimum 75%, Missing)",0.227428,0.173657,-0.143134,0,18,partial,131.7,58,52.6,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 12); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (manageable, limit 30); heart muscle: 47.7 nTPM (vital, limit 1); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 6); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 3); lung: 29.1 nTPM (vital, limit 1); thymus: 28.4 nTPM (manageable, limit 5); skeletal muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 23.4 nTPM (vital, limit 6); colon: 23.3 nTPM (protected, limit 3); parathyroid gland: 22.9 nTPM (protected, limit 3); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 3); lymph node: 17 nTPM (protected, limit 12); esophagus: 16.8 nTPM (protected, limit 12); pancreas: 15.1 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); salivary gland: 13.2 nTPM (protected, limit 3); rectum: 13 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / extracellular matrix: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / extracellular matrix; skin 1 / fibrohistiocytic cells; skin 2 / extracellular matrix; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095794,CREM,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.6866% (minimum 75%, Missing)",0.227428,0.173657,-0.143134,0,18,partial,131.7,58,52.6,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 12); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (manageable, limit 30); heart muscle: 47.7 nTPM (vital, limit 1); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 6); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 3); lung: 29.1 nTPM (vital, limit 1); thymus: 28.4 nTPM (manageable, limit 5); skeletal muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 23.4 nTPM (vital, limit 6); colon: 23.3 nTPM (protected, limit 3); parathyroid gland: 22.9 nTPM (protected, limit 3); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 3); lymph node: 17 nTPM (protected, limit 12); esophagus: 16.8 nTPM (protected, limit 12); pancreas: 15.1 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); salivary gland: 13.2 nTPM (protected, limit 3); rectum: 13 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / extracellular matrix: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / extracellular matrix; skin 1 / fibrohistiocytic cells; skin 2 / extracellular matrix; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095794,CREM,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.6866% (minimum 75%, Baseline (adaptation disabled))",0.144451,0.0780329,-0.143134,0,18,partial,131.7,58,52.6,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 3); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (manageable, limit 5); heart muscle: 47.7 nTPM (vital, limit 1); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 1); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 3); lung: 29.1 nTPM (vital, limit 1); thymus: 28.4 nTPM (manageable, limit 5); skeletal muscle: 28.1 nTPM (vital, limit 1); spleen: 24 nTPM (manageable, limit 5); smooth muscle: 23.4 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 3); parathyroid gland: 22.9 nTPM (protected, limit 3); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); thyroid gland: 21.4 nTPM (manageable, limit 5); stomach: 19.7 nTPM (protected, limit 3); lymph node: 17 nTPM (protected, limit 3); esophagus: 16.8 nTPM (protected, limit 3); small intestine: 15.1 nTPM (vital, limit 1); pancreas: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); salivary gland: 13.2 nTPM (protected, limit 3); rectum: 13 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / extracellular matrix: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / extracellular matrix; skin 1 / fibrohistiocytic cells; skin 2 / extracellular matrix; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000095794,CREM,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 92.7052% (minimum 99%, Missing); choroid plexus: 98.7055% (minimum 99%, Missing); duodenum: 98.7055% (minimum 99%, Missing); midbrain: 95.9119% (minimum 99%, Missing); spinal cord: 98.0707% (minimum 99%, Missing)",0.0213376,0.0202597,-0.0629483,0,80,unavailable,2.4,0.3,0.9,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099338,CATSPERG,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321338,0.29026,0.177052,0,80,unavailable,2.4,0.3,0.9,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099338,CATSPERG,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321338,0.29026,0.177052,0,80,unavailable,2.4,0.3,0.9,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099338,CATSPERG,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321338,0.29026,0.177052,0,80,unavailable,2.4,0.3,0.9,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099338,CATSPERG,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321338,0.29026,0.177052,0,80,unavailable,2.4,0.3,0.9,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099338,CATSPERG,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0.1,0,0,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099399,MAGEB2,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.1,0,0,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099399,MAGEB2,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.1,0,0,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099399,MAGEB2,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.1,0,0,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099399,MAGEB2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246466,0,3,partial,0.1,0,0,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099399,MAGEB2,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 50.0000% (minimum 99%, Missing); thyroid gland: 25.0000% (minimum 95%, Missing)",-0.7,0.03,-0.49,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099721,AMELY,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 50.0000% (minimum 75%, Missing); thyroid gland: 25.0000% (minimum 65%, Missing)",-0.4,0.3,-0.25,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099721,AMELY,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 50.0000% (minimum 75%, Missing); thyroid gland: 25.0000% (minimum 65%, Missing)",-0.4,0.3,-0.25,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099721,AMELY,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 50.0000% (minimum 75%, Missing); thyroid gland: 25.0000% (minimum 65%, Missing)",-0.4,0.3,-0.25,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099721,AMELY,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 50.0000% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 25.0000% (minimum 65%, Baseline (adaptation disabled))",-0.4,0.3,-0.25,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099721,AMELY,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.0321% (minimum 99%, Missing); basal ganglia: 96.5703% (minimum 99%, Missing); choroid plexus: 97.1583% (minimum 99%, Missing); hippocampal formation: 96.9833% (minimum 99%, Missing); hypothalamus: 97.3559% (minimum 99%, Missing); midbrain: 96.7655% (minimum 99%, Missing); pituitary gland: 97.7536% (minimum 99%, Missing); spinal cord: 96.3543% (minimum 99%, Missing)",0.0460694,0.0272222,-0.029679,0,2,partial,17.8,3.8,4.4,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 6); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 6); cerebellum: 6.1 nTPM (vital, limit 6); kidney: 4.1 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099840,IZUMO4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346069,0.297222,0.210321,0,2,partial,17.8,3.8,4.4,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 6); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 6); cerebellum: 6.1 nTPM (vital, limit 6); kidney: 4.1 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099840,IZUMO4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346069,0.297222,0.210321,0,2,partial,17.8,3.8,4.4,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 6); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 6); cerebellum: 6.1 nTPM (vital, limit 6); kidney: 4.1 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099840,IZUMO4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346069,0.297222,0.210321,0,2,partial,17.8,3.8,4.4,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 6); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 6); cerebellum: 6.1 nTPM (vital, limit 6); kidney: 4.1 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099840,IZUMO4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.33989,0.291256,0.210321,0,2,partial,17.8,3.8,4.4,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099840,IZUMO4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8580% (minimum 99%, Missing); duodenum: 95.4514% (minimum 98%, Approved); heart muscle: 95.1890% (minimum 99%, Missing); kidney: 98.2270% (minimum 99%, Missing); salivary gland: 96.4485% (minimum 97%, Missing); small intestine: 95.9141% (minimum 99%, Missing); smooth muscle: 93.8347% (minimum 98%, Approved)",0.0274171,-0.00551532,-0.0416531,0,0,routine_complete,9.1,5.1,3.7,"smooth muscle: 9.1 nTPM (vital, limit 2); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 2); small intestine: 5.9 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); adrenal gland: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099953,MMP11,admission_only,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327417,0.264485,0.20189,0,0,routine_complete,9.1,5.1,3.7,"smooth muscle: 9.1 nTPM (vital, limit 2); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 2); small intestine: 5.9 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); adrenal gland: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099953,MMP11,selectivity_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327417,0.264485,0.20189,0,0,routine_complete,9.1,5.1,3.7,"smooth muscle: 9.1 nTPM (vital, limit 2); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 2); small intestine: 5.9 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099953,MMP11,grid_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327417,0.264485,0.20189,0,0,routine_complete,9.1,5.1,3.7,"smooth muscle: 9.1 nTPM (vital, limit 2); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 2); small intestine: 5.9 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099953,MMP11,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.32398,0.264485,0.188347,0,0,routine_complete,9.1,5.1,3.7,"smooth muscle: 9.1 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 3); lymph node: 3.9 nTPM (protected, limit 3); colon: 3.8 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000099953,MMP11,current_fixed,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.1649% (minimum 99%, Missing); amygdala: 88.7059% (minimum 99%, Missing); basal ganglia: 74.8759% (minimum 99%, Missing); bone marrow: 92.2889% (minimum 99%, Missing); cerebellum: 91.0628% (minimum 99%, Missing); cerebral cortex: 86.1714% (minimum 99%, Missing); choroid plexus: 86.6667% (minimum 99%, Missing); colon: 95.9288% (minimum 97%, Missing); duodenum: 97.0399% (minimum 99%, Missing); heart muscle: 91.5049% (minimum 99%, Missing); hippocampal formation: 90.6250% (minimum 99%, Missing); hypothalamus: 92.4020% (minimum 99%, Missing); kidney: 97.0399% (minimum 99%, Missing); liver: 96.9152% (minimum 99%, Missing); lung: 93.3168% (minimum 99%, Missing); lymph node: 92.9716% (minimum 97%, Missing); midbrain: 96.1735% (minimum 99%, Missing); pancreas: 95.2020% (minimum 99%, Missing); parathyroid gland: 95.9288% (minimum 97%, Missing); pituitary gland: 96.7908% (minimum 99%, Missing); retina: 95.4430% (minimum 99%, Missing); salivary gland: 96.6667% (minimum 97%, Missing); skeletal muscle: 83.2230% (minimum 99%, Missing); small intestine: 96.9152% (minimum 99%, Missing); smooth muscle: 96.9152% (minimum 99%, Missing); spinal cord: 94.9622% (minimum 99%, Missing); spleen: 90.1914% (minimum 95%, Missing); stomach: 95.8069% (minimum 97%, Missing); thymus: 84.1518% (minimum 95%, Missing); tongue: 92.4020% (minimum 97%, Missing)",-0.108482,-0.0459804,-0.241241,0,2,partial,25.3,6.2,14.2,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); thymus: 14.2 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 2); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); midbrain: 3 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100027,YPEL1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 74.8759% (minimum 75%, Missing)",0.191518,0.22402,-0.00124131,0,2,partial,25.3,6.2,14.2,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); thymus: 14.2 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 2); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); midbrain: 3 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100027,YPEL1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 74.8759% (minimum 75%, Missing)",0.191518,0.22402,-0.00124131,0,2,partial,25.3,6.2,14.2,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); thymus: 14.2 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 3); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); colon: 3.2 nTPM (protected, limit 3); midbrain: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100027,YPEL1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 74.8759% (minimum 75%, Missing)",0.191518,0.22402,-0.00124131,0,2,partial,25.3,6.2,14.2,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); thymus: 14.2 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 3); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); colon: 3.2 nTPM (protected, limit 3); midbrain: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100027,YPEL1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 74.8759% (minimum 75%, Baseline (adaptation disabled))",0.191518,0.22402,-0.00124131,0,2,partial,25.3,6.2,14.2,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); thymus: 14.2 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 3); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); colon: 3.2 nTPM (protected, limit 3); midbrain: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100027,YPEL1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.6350% (minimum 99%, Missing); cerebral cortex: 98.3673% (minimum 99%, Missing); choroid plexus: 92.3372% (minimum 99%, Missing); duodenum: 97.5709% (minimum 99%, Missing); kidney: 97.5709% (minimum 99%, Missing); lung: 96.4000% (minimum 99%, Missing); lymph node: 92.3372% (minimum 97%, Missing); pancreas: 96.4000% (minimum 99%, Missing); retina: 98.7705% (minimum 99%, Missing); skeletal muscle: 98.3673% (minimum 99%, Missing); skin: 91.2879% (minimum 95%, Missing); small intestine: 95.6349% (minimum 99%, Missing); spleen: 83.3910% (minimum 95%, Missing)",-0.11609,-0.0466284,-0.0736502,0,80,unavailable,2.2,2,4.8,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100121,GGTLC2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.18391,0.223372,0.16635,0,80,unavailable,2.2,2,4.8,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100121,GGTLC2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.18391,0.223372,0.16635,0,80,unavailable,2.2,2,4.8,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100121,GGTLC2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.18391,0.223372,0.16635,0,80,unavailable,2.2,2,4.8,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100121,GGTLC2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.18391,0.223372,0.16635,0,80,unavailable,2.2,2,4.8,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100121,GGTLC2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.0413% (minimum 99%, Missing); basal ganglia: 95.0413% (minimum 99%, Missing); bone marrow: 85.8209% (minimum 95%, Enhanced); cerebral cortex: 94.2623% (minimum 95%, Enhanced); choroid plexus: 96.6387% (minimum 99%, Missing); heart muscle: 83.9416% (minimum 99%, Missing); hippocampal formation: 96.6387% (minimum 99%, Missing); hypothalamus: 96.6387% (minimum 99%, Missing); midbrain: 96.6387% (minimum 99%, Missing); pituitary gland: 97.4576% (minimum 99%, Missing); retina: 94.2623% (minimum 99%, Missing); skeletal muscle: 90.5512% (minimum 95%, Enhanced); smooth muscle: 94.2623% (minimum 95%, Enhanced); spinal cord: 95.8333% (minimum 99%, Missing); thymus: 78.2313% (minimum 95%, Missing); tongue: 95.8333% (minimum 97%, Missing)",-0.167687,-0.0116667,-0.150584,0,2,partial,2.2,2.6,3.2,"heart muscle: 2.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100206,DMC1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.132313,0.258333,0.0894161,0,2,partial,2.2,2.6,3.2,"heart muscle: 2.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100206,DMC1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.132313,0.258333,0.0894161,0,2,partial,2.2,2.6,3.2,"heart muscle: 2.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100206,DMC1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.132313,0.258333,0.0894161,0,2,partial,2.2,2.6,3.2,"heart muscle: 2.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100206,DMC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.132313,0.115603,0.0894161,0,2,partial,2.2,2.6,3.2,"heart muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100206,DMC1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.9437% (minimum 99%, Missing)",0.05,0.03,-0.00056338,0,3,partial,1.9,0.6,2.9,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100312,ACR,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.239437,0,3,partial,1.9,0.6,2.9,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100312,ACR,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.239437,0,3,partial,1.9,0.6,2.9,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100312,ACR,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.239437,0,3,partial,1.9,0.6,2.9,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100312,ACR,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316743,0.292933,0.227958,0,3,partial,1.9,0.6,2.9,"lung: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100312,ACR,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.5957% (minimum 95%, Missing); adrenal gland: 75.7895% (minimum 99%, Missing); amygdala: 55.8140% (minimum 99%, Missing); basal ganglia: 53.9326% (minimum 99%, Missing); bone marrow: 69.2308% (minimum 99%, Missing); cerebellum: 56.2500% (minimum 99%, Missing); cerebral cortex: 47.0588% (minimum 99%, Missing); choroid plexus: 83.2370% (minimum 99%, Missing); colon: 63.7168% (minimum 97%, Missing); duodenum: 82.7586% (minimum 99%, Missing); esophagus: 78.6885% (minimum 97%, Missing); heart muscle: 67.2897% (minimum 99%, Missing); hippocampal formation: 55.5985% (minimum 99%, Missing); hypothalamus: 58.0645% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 75.3927% (minimum 99%, Missing); lung: 75.7895% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 63.7168% (minimum 99%, Missing); pancreas: 67.9245% (minimum 99%, Missing); parathyroid gland: 77.0053% (minimum 97%, Missing); pituitary gland: 64.0000% (minimum 99%, Missing); rectum: 80.4469% (minimum 97%, Missing); retina: 59.2593% (minimum 99%, Missing); salivary gland: 74.6114% (minimum 97%, Missing); skeletal muscle: 56.4706% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 77.8378% (minimum 99%, Missing); smooth muscle: 69.5652% (minimum 99%, Missing); spinal cord: 65.4545% (minimum 99%, Missing); spleen: 68.8995% (minimum 95%, Missing); stomach: 77.8378% (minimum 97%, Missing); thymus: 75.7895% (minimum 95%, Missing); thyroid gland: 66.9767% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 70.5882% (minimum 97%, Missing)",-0.280233,-0.332832,-0.519412,0,4,partial,16.2,8.2,7.1,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 2); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thyroid gland: 7.1 nTPM (manageable, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); salivary gland: 4.9 nTPM (protected, limit 2); tongue: 4.8 nTPM (protected, limit 2); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); small intestine: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); esophagus: 3.9 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100478,AP4S1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 55.8140% (minimum 75%, Missing); basal ganglia: 53.9326% (minimum 75%, Missing); bone marrow: 69.2308% (minimum 75%, Missing); cerebellum: 56.2500% (minimum 75%, Missing); cerebral cortex: 47.0588% (minimum 75%, Missing); colon: 63.7168% (minimum 70%, Missing); heart muscle: 67.2897% (minimum 75%, Missing); hippocampal formation: 55.5985% (minimum 75%, Missing); hypothalamus: 58.0645% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 63.7168% (minimum 75%, Missing); pancreas: 67.9245% (minimum 75%, Missing); pituitary gland: 64.0000% (minimum 75%, Missing); retina: 59.2593% (minimum 75%, Missing); skeletal muscle: 56.4706% (minimum 75%, Missing); smooth muscle: 69.5652% (minimum 75%, Missing); spinal cord: 65.4545% (minimum 75%, Missing)",0.0197674,-0.0628319,-0.279412,0,4,partial,16.2,8.2,7.1,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 2); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thyroid gland: 7.1 nTPM (manageable, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); salivary gland: 4.9 nTPM (protected, limit 2); tongue: 4.8 nTPM (protected, limit 2); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); small intestine: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); esophagus: 3.9 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100478,AP4S1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 55.8140% (minimum 75%, Missing); basal ganglia: 53.9326% (minimum 75%, Missing); bone marrow: 69.2308% (minimum 75%, Missing); cerebellum: 56.2500% (minimum 75%, Missing); cerebral cortex: 47.0588% (minimum 75%, Missing); colon: 63.7168% (minimum 70%, Missing); heart muscle: 67.2897% (minimum 75%, Missing); hippocampal formation: 55.5985% (minimum 75%, Missing); hypothalamus: 58.0645% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 63.7168% (minimum 75%, Missing); pancreas: 67.9245% (minimum 75%, Missing); pituitary gland: 64.0000% (minimum 75%, Missing); retina: 59.2593% (minimum 75%, Missing); skeletal muscle: 56.4706% (minimum 75%, Missing); smooth muscle: 69.5652% (minimum 75%, Missing); spinal cord: 65.4545% (minimum 75%, Missing)",0.0197674,-0.0628319,-0.279412,0,4,partial,16.2,8.2,7.1,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 3); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thyroid gland: 7.1 nTPM (manageable, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); salivary gland: 4.9 nTPM (protected, limit 3); tongue: 4.8 nTPM (protected, limit 3); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); small intestine: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); esophagus: 3.9 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100478,AP4S1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 55.8140% (minimum 75%, Missing); basal ganglia: 53.9326% (minimum 75%, Missing); bone marrow: 69.2308% (minimum 75%, Missing); cerebellum: 56.2500% (minimum 75%, Missing); cerebral cortex: 47.0588% (minimum 75%, Missing); colon: 63.7168% (minimum 70%, Missing); heart muscle: 67.2897% (minimum 75%, Missing); hippocampal formation: 55.5985% (minimum 75%, Missing); hypothalamus: 58.0645% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 63.7168% (minimum 75%, Missing); pancreas: 67.9245% (minimum 75%, Missing); pituitary gland: 64.0000% (minimum 75%, Missing); retina: 59.2593% (minimum 75%, Missing); skeletal muscle: 56.4706% (minimum 75%, Missing); smooth muscle: 69.5652% (minimum 75%, Missing); spinal cord: 65.4545% (minimum 75%, Missing)",0.0197674,-0.0628319,-0.279412,0,4,partial,16.2,8.2,7.1,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 3); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thyroid gland: 7.1 nTPM (manageable, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); salivary gland: 4.9 nTPM (protected, limit 3); tongue: 4.8 nTPM (protected, limit 3); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); small intestine: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); esophagus: 3.9 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100478,AP4S1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 55.8140% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 53.9326% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 69.2308% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.2500% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 47.0588% (minimum 75%, Baseline (adaptation disabled)); colon: 63.7168% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 67.2897% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.5985% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.0645% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); midbrain: 63.7168% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.9245% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 64.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 59.2593% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 56.4706% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 69.5652% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.4545% (minimum 75%, Baseline (adaptation disabled))",0.0197674,-0.0628319,-0.279412,0,4,partial,16.2,8.2,7.1,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 3); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thyroid gland: 7.1 nTPM (manageable, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); salivary gland: 4.9 nTPM (protected, limit 3); tongue: 4.8 nTPM (protected, limit 3); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); small intestine: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); esophagus: 3.9 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100478,AP4S1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.8462% (minimum 95%, Uncertain); adrenal gland: 82.0000% (minimum 99%, Uncertain); amygdala: 93.1818% (minimum 99%, Missing); basal ganglia: 95.3488% (minimum 99%, Missing); bone marrow: 18.4685% (minimum 99%, Missing); cerebellum: 91.1111% (minimum 99%, Uncertain); cerebral cortex: 89.1304% (minimum 99%, Uncertain); choroid plexus: 83.6735% (minimum 99%, Missing); colon: 52.5641% (minimum 97%, Missing); duodenum: 63.0769% (minimum 99%, Uncertain); esophagus: 53.2468% (minimum 97%, Missing); heart muscle: 87.2340% (minimum 99%, Uncertain); hippocampal formation: 93.1818% (minimum 99%, Missing); hypothalamus: 91.1111% (minimum 99%, Missing); kidney: 85.4167% (minimum 99%, Uncertain); liver: 56.1644% (minimum 99%, Uncertain); lung: 78.8462% (minimum 99%, Uncertain); lymph node: 44.0860% (minimum 97%, Missing); midbrain: 93.1818% (minimum 99%, Missing); pancreas: 77.3585% (minimum 99%, Uncertain); parathyroid gland: 87.2340% (minimum 97%, Uncertain); pituitary gland: 89.1304% (minimum 99%, Missing); rectum: 47.1264% (minimum 97%, Uncertain); retina: 53.9474% (minimum 99%, Missing); salivary gland: 80.3922% (minimum 97%, Uncertain); skeletal muscle: 85.4167% (minimum 99%, Uncertain); skin: 53.9474% (minimum 95%, Missing); small intestine: 53.2468% (minimum 99%, Uncertain); smooth muscle: 65.0794% (minimum 99%, Uncertain); spinal cord: 89.1304% (minimum 99%, Missing); spleen: 74.5455% (minimum 95%, Uncertain); stomach: 65.0794% (minimum 97%, Uncertain); thymus: 42.2680% (minimum 95%, Missing); thyroid gland: 82.0000% (minimum 95%, Uncertain); tongue: 80.3922% (minimum 97%, Missing); urinary bladder: 75.9259% (minimum 97%, Missing)",-0.52732,-0.52914,-0.805315,0,1,partial,18.1,5.2,5.6,"bone marrow: 18.1 nTPM (vital, limit 1); thymus: 5.6 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100479,POLE2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 18.4685% (minimum 75%, Missing); colon: 52.5641% (minimum 70%, Missing); duodenum: 63.0769% (minimum 75%, Uncertain); esophagus: 53.2468% (minimum 70%, Missing); liver: 56.1644% (minimum 75%, Uncertain); lymph node: 44.0860% (minimum 70%, Missing); rectum: 47.1264% (minimum 70%, Uncertain); retina: 53.9474% (minimum 75%, Missing); skin: 53.9474% (minimum 65%, Missing); small intestine: 53.2468% (minimum 75%, Uncertain); smooth muscle: 65.0794% (minimum 75%, Uncertain); stomach: 65.0794% (minimum 70%, Uncertain); thymus: 42.2680% (minimum 65%, Missing)",-0.22732,-0.25914,-0.565315,0,1,partial,18.1,5.2,5.6,"bone marrow: 18.1 nTPM (vital, limit 1); thymus: 5.6 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100479,POLE2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 18.4685% (minimum 75%, Missing); colon: 52.5641% (minimum 70%, Missing); duodenum: 63.0769% (minimum 75%, Uncertain); esophagus: 53.2468% (minimum 70%, Missing); liver: 56.1644% (minimum 75%, Uncertain); lymph node: 44.0860% (minimum 70%, Missing); rectum: 47.1264% (minimum 70%, Uncertain); retina: 53.9474% (minimum 75%, Missing); skin: 53.9474% (minimum 65%, Missing); small intestine: 53.2468% (minimum 75%, Uncertain); smooth muscle: 65.0794% (minimum 75%, Uncertain); stomach: 65.0794% (minimum 70%, Uncertain); thymus: 42.2680% (minimum 65%, Missing)",-0.22732,-0.25914,-0.565315,0,1,partial,18.1,5.2,5.6,"bone marrow: 18.1 nTPM (vital, limit 1); thymus: 5.6 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); colon: 3.7 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100479,POLE2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 18.4685% (minimum 75%, Missing); colon: 52.5641% (minimum 70%, Missing); duodenum: 63.0769% (minimum 75%, Uncertain); esophagus: 53.2468% (minimum 70%, Missing); liver: 56.1644% (minimum 75%, Uncertain); lymph node: 44.0860% (minimum 70%, Missing); rectum: 47.1264% (minimum 70%, Uncertain); retina: 53.9474% (minimum 75%, Missing); skin: 53.9474% (minimum 65%, Missing); small intestine: 53.2468% (minimum 75%, Uncertain); smooth muscle: 65.0794% (minimum 75%, Uncertain); stomach: 65.0794% (minimum 70%, Uncertain); thymus: 42.2680% (minimum 65%, Missing)",-0.22732,-0.25914,-0.565315,0,1,partial,18.1,5.2,5.6,"bone marrow: 18.1 nTPM (vital, limit 1); thymus: 5.6 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); colon: 3.7 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100479,POLE2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 18.4685% (minimum 75%, Baseline (adaptation disabled)); colon: 52.5641% (minimum 70%, Baseline (adaptation disabled)); duodenum: 63.0769% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.2468% (minimum 70%, Baseline (adaptation disabled)); liver: 56.1644% (minimum 75%, Baseline (adaptation disabled)); lymph node: 44.0860% (minimum 70%, Baseline (adaptation disabled)); rectum: 47.1264% (minimum 70%, Baseline (adaptation disabled)); retina: 53.9474% (minimum 75%, Baseline (adaptation disabled)); skin: 53.9474% (minimum 65%, Baseline (adaptation disabled)); small intestine: 53.2468% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.0794% (minimum 75%, Baseline (adaptation disabled)); stomach: 65.0794% (minimum 70%, Baseline (adaptation disabled)); thymus: 42.2680% (minimum 65%, Baseline (adaptation disabled))",-0.22732,-0.25914,-0.565315,0,1,partial,18.1,5.2,5.6,"bone marrow: 18.1 nTPM (vital, limit 1); thymus: 5.6 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); colon: 3.7 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100479,POLE2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1082% (minimum 90%, Approved); adrenal gland: 65.2174% (minimum 99%, Missing); amygdala: 65.2174% (minimum 99%, Missing); basal ganglia: 64.7482% (minimum 99%, Missing); bone marrow: 40.9091% (minimum 99%, Missing); cerebellum: 75.8427% (minimum 99%, Missing); cerebral cortex: 66.5025% (minimum 99%, Missing); choroid plexus: 82.0669% (minimum 99%, Missing); colon: 61.6438% (minimum 97%, Missing); duodenum: 56.4854% (minimum 99%, Missing); esophagus: 63.0841% (minimum 97%, Missing); heart muscle: 56.6038% (minimum 99%, Missing); hippocampal formation: 63.9810% (minimum 99%, Missing); hypothalamus: 69.7674% (minimum 99%, Missing); kidney: 53.3597% (minimum 99%, Missing); liver: 68.0101% (minimum 98%, Approved); lung: 63.9810% (minimum 99%, Missing); lymph node: 65.8537% (minimum 97%, Missing); midbrain: 61.7849% (minimum 99%, Missing); pancreas: 63.8298% (minimum 99%, Missing); parathyroid gland: 41.6025% (minimum 97%, Missing); pituitary gland: 75.2089% (minimum 99%, Missing); rectum: 61.7849% (minimum 97%, Missing); retina: 66.9975% (minimum 99%, Missing); salivary gland: 65.6934% (minimum 97%, Missing); skeletal muscle: 32.7670% (minimum 99%, Missing); skin: 61.2245% (minimum 95%, Missing); small intestine: 53.2544% (minimum 99%, Missing); smooth muscle: 60.9481% (minimum 99%, Missing); spinal cord: 56.3674% (minimum 99%, Missing); spleen: 60.9481% (minimum 95%, Missing); stomach: 66.9975% (minimum 97%, Missing); thymus: 62.9371% (minimum 95%, Missing); thyroid gland: 52.5292% (minimum 95%, Missing); tongue: 30.5776% (minimum 97%, Missing); urinary bladder: 65.5340% (minimum 97%, Missing)",-0.424708,-0.664224,-0.66233,0,6,partial,55.4,61.3,24.4,"tongue: 61.3 nTPM (protected, limit 2); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 2); thyroid gland: 24.4 nTPM (manageable, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 10); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); spleen: 17.3 nTPM (manageable, limit 5); smooth muscle: 17.3 nTPM (vital, limit 1); skin: 17.1 nTPM (manageable, limit 5); colon: 16.8 nTPM (protected, limit 2); rectum: 16.7 nTPM (protected, limit 2); midbrain: 16.7 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 2); pancreas: 15.3 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 2); salivary gland: 14.1 nTPM (protected, limit 2); lymph node: 14 nTPM (protected, limit 2); cerebral cortex: 13.6 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); retina: 13.3 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100485,SOS2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1082% (minimum 60%, Approved); adrenal gland: 65.2174% (minimum 75%, Missing); amygdala: 65.2174% (minimum 75%, Missing); basal ganglia: 64.7482% (minimum 75%, Missing); bone marrow: 40.9091% (minimum 75%, Missing); cerebral cortex: 66.5025% (minimum 75%, Missing); colon: 61.6438% (minimum 70%, Missing); duodenum: 56.4854% (minimum 75%, Missing); esophagus: 63.0841% (minimum 70%, Missing); heart muscle: 56.6038% (minimum 75%, Missing); hippocampal formation: 63.9810% (minimum 75%, Missing); hypothalamus: 69.7674% (minimum 75%, Missing); kidney: 53.3597% (minimum 75%, Missing); liver: 68.0101% (minimum 70%, Approved); lung: 63.9810% (minimum 75%, Missing); lymph node: 65.8537% (minimum 70%, Missing); midbrain: 61.7849% (minimum 75%, Missing); pancreas: 63.8298% (minimum 75%, Missing); parathyroid gland: 41.6025% (minimum 70%, Missing); rectum: 61.7849% (minimum 70%, Missing); retina: 66.9975% (minimum 75%, Missing); salivary gland: 65.6934% (minimum 70%, Missing); skeletal muscle: 32.7670% (minimum 75%, Missing); skin: 61.2245% (minimum 65%, Missing); small intestine: 53.2544% (minimum 75%, Missing); smooth muscle: 60.9481% (minimum 75%, Missing); spinal cord: 56.3674% (minimum 75%, Missing); spleen: 60.9481% (minimum 65%, Missing); stomach: 66.9975% (minimum 70%, Missing); thymus: 62.9371% (minimum 65%, Missing); thyroid gland: 52.5292% (minimum 65%, Missing); tongue: 30.5776% (minimum 70%, Missing); urinary bladder: 65.5340% (minimum 70%, Missing)",-0.124708,-0.394224,-0.42233,0,6,partial,55.4,61.3,24.4,"tongue: 61.3 nTPM (protected, limit 2); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 2); thyroid gland: 24.4 nTPM (manageable, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 10); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); spleen: 17.3 nTPM (manageable, limit 5); smooth muscle: 17.3 nTPM (vital, limit 1); skin: 17.1 nTPM (manageable, limit 5); colon: 16.8 nTPM (protected, limit 2); rectum: 16.7 nTPM (protected, limit 2); midbrain: 16.7 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 2); pancreas: 15.3 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 2); salivary gland: 14.1 nTPM (protected, limit 2); lymph node: 14 nTPM (protected, limit 2); cerebral cortex: 13.6 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); retina: 13.3 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100485,SOS2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1082% (minimum 60%, Approved); adrenal gland: 65.2174% (minimum 75%, Missing); amygdala: 65.2174% (minimum 75%, Missing); basal ganglia: 64.7482% (minimum 75%, Missing); bone marrow: 40.9091% (minimum 75%, Missing); cerebral cortex: 66.5025% (minimum 75%, Missing); colon: 61.6438% (minimum 70%, Missing); duodenum: 56.4854% (minimum 75%, Missing); esophagus: 63.0841% (minimum 70%, Missing); heart muscle: 56.6038% (minimum 75%, Missing); hippocampal formation: 63.9810% (minimum 75%, Missing); hypothalamus: 69.7674% (minimum 75%, Missing); kidney: 53.3597% (minimum 75%, Missing); liver: 68.0101% (minimum 70%, Approved); lung: 63.9810% (minimum 75%, Missing); lymph node: 65.8537% (minimum 70%, Missing); midbrain: 61.7849% (minimum 75%, Missing); pancreas: 63.8298% (minimum 75%, Missing); parathyroid gland: 41.6025% (minimum 70%, Missing); rectum: 61.7849% (minimum 70%, Missing); retina: 66.9975% (minimum 75%, Missing); salivary gland: 65.6934% (minimum 70%, Missing); skeletal muscle: 32.7670% (minimum 75%, Missing); skin: 61.2245% (minimum 65%, Missing); small intestine: 53.2544% (minimum 75%, Missing); smooth muscle: 60.9481% (minimum 75%, Missing); spinal cord: 56.3674% (minimum 75%, Missing); spleen: 60.9481% (minimum 65%, Missing); stomach: 66.9975% (minimum 70%, Missing); thymus: 62.9371% (minimum 65%, Missing); thyroid gland: 52.5292% (minimum 65%, Missing); tongue: 30.5776% (minimum 70%, Missing); urinary bladder: 65.5340% (minimum 70%, Missing)",-0.124708,-0.394224,-0.42233,0,6,partial,55.4,61.3,24.4,"tongue: 61.3 nTPM (protected, limit 3); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 3); thyroid gland: 24.4 nTPM (manageable, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 10); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); spleen: 17.3 nTPM (manageable, limit 5); smooth muscle: 17.3 nTPM (vital, limit 1); skin: 17.1 nTPM (manageable, limit 5); colon: 16.8 nTPM (protected, limit 3); rectum: 16.7 nTPM (protected, limit 3); midbrain: 16.7 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 3); pancreas: 15.3 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 3); salivary gland: 14.1 nTPM (protected, limit 3); lymph node: 14 nTPM (protected, limit 3); cerebral cortex: 13.6 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); retina: 13.3 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100485,SOS2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1082% (minimum 60%, Approved); adrenal gland: 65.2174% (minimum 75%, Missing); amygdala: 65.2174% (minimum 75%, Missing); basal ganglia: 64.7482% (minimum 75%, Missing); bone marrow: 40.9091% (minimum 75%, Missing); cerebral cortex: 66.5025% (minimum 75%, Missing); colon: 61.6438% (minimum 70%, Missing); duodenum: 56.4854% (minimum 75%, Missing); esophagus: 63.0841% (minimum 70%, Missing); heart muscle: 56.6038% (minimum 75%, Missing); hippocampal formation: 63.9810% (minimum 75%, Missing); hypothalamus: 69.7674% (minimum 75%, Missing); kidney: 53.3597% (minimum 75%, Missing); liver: 68.0101% (minimum 70%, Approved); lung: 63.9810% (minimum 75%, Missing); lymph node: 65.8537% (minimum 70%, Missing); midbrain: 61.7849% (minimum 75%, Missing); pancreas: 63.8298% (minimum 75%, Missing); parathyroid gland: 41.6025% (minimum 70%, Missing); rectum: 61.7849% (minimum 70%, Missing); retina: 66.9975% (minimum 75%, Missing); salivary gland: 65.6934% (minimum 70%, Missing); skeletal muscle: 32.7670% (minimum 75%, Missing); skin: 61.2245% (minimum 65%, Missing); small intestine: 53.2544% (minimum 75%, Missing); smooth muscle: 60.9481% (minimum 75%, Missing); spinal cord: 56.3674% (minimum 75%, Missing); spleen: 60.9481% (minimum 65%, Missing); stomach: 66.9975% (minimum 70%, Missing); thymus: 62.9371% (minimum 65%, Missing); thyroid gland: 52.5292% (minimum 65%, Missing); tongue: 30.5776% (minimum 70%, Missing); urinary bladder: 65.5340% (minimum 70%, Missing)",-0.124708,-0.394224,-0.42233,0,6,partial,55.4,61.3,24.4,"tongue: 61.3 nTPM (protected, limit 3); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 3); thyroid gland: 24.4 nTPM (manageable, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 10); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); spleen: 17.3 nTPM (manageable, limit 5); smooth muscle: 17.3 nTPM (vital, limit 1); skin: 17.1 nTPM (manageable, limit 5); colon: 16.8 nTPM (protected, limit 3); rectum: 16.7 nTPM (protected, limit 3); midbrain: 16.7 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 3); pancreas: 15.3 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 3); salivary gland: 14.1 nTPM (protected, limit 3); lymph node: 14 nTPM (protected, limit 3); cerebral cortex: 13.6 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); retina: 13.3 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100485,SOS2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1082% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 65.2174% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.2174% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.7482% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 40.9091% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.5025% (minimum 75%, Baseline (adaptation disabled)); colon: 61.6438% (minimum 70%, Baseline (adaptation disabled)); duodenum: 56.4854% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.0841% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 56.6038% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.9810% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.7674% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.3597% (minimum 75%, Baseline (adaptation disabled)); liver: 68.0101% (minimum 75%, Baseline (adaptation disabled)); lung: 63.9810% (minimum 75%, Baseline (adaptation disabled)); lymph node: 65.8537% (minimum 70%, Baseline (adaptation disabled)); midbrain: 61.7849% (minimum 75%, Baseline (adaptation disabled)); pancreas: 63.8298% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 41.6025% (minimum 70%, Baseline (adaptation disabled)); rectum: 61.7849% (minimum 70%, Baseline (adaptation disabled)); retina: 66.9975% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.6934% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 32.7670% (minimum 75%, Baseline (adaptation disabled)); skin: 61.2245% (minimum 65%, Baseline (adaptation disabled)); small intestine: 53.2544% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.9481% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.3674% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.9481% (minimum 65%, Baseline (adaptation disabled)); stomach: 66.9975% (minimum 70%, Baseline (adaptation disabled)); thymus: 62.9371% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.5292% (minimum 65%, Baseline (adaptation disabled)); tongue: 30.5776% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.5340% (minimum 70%, Baseline (adaptation disabled))",-0.124708,-0.394224,-0.42233,0,6,partial,55.4,61.3,24.4,"tongue: 61.3 nTPM (protected, limit 3); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 3); thyroid gland: 24.4 nTPM (manageable, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 5); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); spleen: 17.3 nTPM (manageable, limit 5); smooth muscle: 17.3 nTPM (vital, limit 1); skin: 17.1 nTPM (manageable, limit 5); colon: 16.8 nTPM (protected, limit 3); rectum: 16.7 nTPM (protected, limit 3); midbrain: 16.7 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 3); pancreas: 15.3 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 3); salivary gland: 14.1 nTPM (protected, limit 3); lymph node: 14 nTPM (protected, limit 3); cerebral cortex: 13.6 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); retina: 13.3 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100485,SOS2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 89.5210% (minimum 99%, Missing); amygdala: 83.5196% (minimum 99%, Missing); basal ganglia: 83.9888% (minimum 99%, Missing); bone marrow: 77.6623% (minimum 95%, Enhanced); cerebellum: 77.8646% (minimum 99%, Missing); cerebral cortex: 81.0298% (minimum 99%, Missing); choroid plexus: 93.4375% (minimum 99%, Missing); colon: 88.9881% (minimum 97%, Missing); duodenum: 92.2840% (minimum 99%, Missing); heart muscle: 85.9195% (minimum 99%, Missing); hippocampal formation: 81.6940% (minimum 99%, Missing); hypothalamus: 83.0556% (minimum 99%, Missing); kidney: 93.1464% (minimum 99%, Missing); liver: 92.0000% (minimum 99%, Missing); lung: 85.4286% (minimum 99%, Missing); lymph node: 75.5051% (minimum 80%, Enhanced); midbrain: 79.9465% (minimum 99%, Missing); pancreas: 91.4373% (minimum 99%, Missing); parathyroid gland: 87.4269% (minimum 97%, Missing); pituitary gland: 85.1852% (minimum 99%, Missing); rectum: 86.9186% (minimum 97%, Missing); retina: 65.0000% (minimum 99%, Missing); salivary gland: 92.5697% (minimum 97%, Missing); skeletal muscle: 90.8815% (minimum 95%, Enhanced); skin: 90.0602% (minimum 95%, Missing); small intestine: 86.6667% (minimum 99%, Missing); smooth muscle: 85.9195% (minimum 95%, Enhanced); spinal cord: 76.0814% (minimum 99%, Missing); stomach: 88.9881% (minimum 97%, Missing); thymus: 82.3691% (minimum 95%, Missing); thyroid gland: 89.7898% (minimum 95%, Missing); tongue: 85.4286% (minimum 97%, Missing); urinary bladder: 84.9432% (minimum 97%, Missing)",-0.126309,-0.120568,-0.34,0,4,partial,16.1,9.7,6.4,"retina: 16.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 6); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thymus: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 2); pituitary gland: 5.2 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 2); lung: 5.1 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); parathyroid gland: 4.3 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100523,DDHD1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 65.0000% (minimum 75%, Missing)",0.173691,0.149432,-0.1,0,4,partial,16.1,9.7,6.4,"retina: 16.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 6); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thymus: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 2); pituitary gland: 5.2 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 2); lung: 5.1 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); parathyroid gland: 4.3 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100523,DDHD1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 65.0000% (minimum 75%, Missing)",0.173691,0.149432,-0.1,0,4,partial,16.1,9.7,6.4,"retina: 16.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 6); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thymus: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 3); pituitary gland: 5.2 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 3); heart muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); parathyroid gland: 4.3 nTPM (protected, limit 3); colon: 3.7 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100523,DDHD1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 65.0000% (minimum 75%, Missing)",0.173691,0.149432,-0.1,0,4,partial,16.1,9.7,6.4,"retina: 16.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 6); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thymus: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 3); pituitary gland: 5.2 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 3); heart muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); parathyroid gland: 4.3 nTPM (protected, limit 3); colon: 3.7 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100523,DDHD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 65.0000% (minimum 75%, Baseline (adaptation disabled))",0.173691,0.0550505,-0.1,0,4,partial,16.1,9.7,6.4,"retina: 16.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 3); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thymus: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); spleen: 6 nTPM (manageable, limit 5); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 3); pituitary gland: 5.2 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 3); smooth muscle: 4.9 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); parathyroid gland: 4.3 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); colon: 3.7 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100523,DDHD1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.4729% (minimum 99%, Missing); basal ganglia: 98.6673% (minimum 99%, Missing); bone marrow: 82.5351% (minimum 99%, Missing); cerebellum: 98.5700% (minimum 99%, Missing); cerebral cortex: 97.8463% (minimum 99%, Missing); choroid plexus: 94.3370% (minimum 99%, Missing); colon: 93.6739% (minimum 97%, Missing); duodenum: 94.2480% (minimum 99%, Missing); esophagus: 95.2812% (minimum 97%, Missing); heart muscle: 97.5122% (minimum 99%, Missing); hippocampal formation: 98.7160% (minimum 99%, Missing); hypothalamus: 98.0864% (minimum 99%, Missing); liver: 98.8625% (minimum 99%, Missing); lymph node: 87.8295% (minimum 97%, Missing); midbrain: 98.5214% (minimum 99%, Missing); rectum: 92.4179% (minimum 97%, Missing); retina: 98.8136% (minimum 99%, Missing); skeletal muscle: 98.5700% (minimum 99%, Missing); small intestine: 94.2925% (minimum 99%, Missing); smooth muscle: 96.5234% (minimum 99%, Missing); thymus: 86.8753% (minimum 95%, Missing)",-0.0812473,-0.0917047,-0.164649,0,80,unavailable,42.3,27.7,30.2,"bone marrow: 42.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); lymph node: 27.7 nTPM (protected, limit 2); rectum: 16.4 nTPM (protected, limit 2); colon: 13.5 nTPM (protected, limit 2); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); stomach: 4.9 nTPM (protected, limit 2); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100526,CDKN3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.218753,0.178295,0.0753509,0,80,unavailable,42.3,27.7,30.2,"bone marrow: 42.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); lymph node: 27.7 nTPM (protected, limit 2); rectum: 16.4 nTPM (protected, limit 2); colon: 13.5 nTPM (protected, limit 2); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); stomach: 4.9 nTPM (protected, limit 2); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100526,CDKN3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.218753,0.178295,0.0753509,0,80,unavailable,42.3,27.7,30.2,"bone marrow: 42.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); lymph node: 27.7 nTPM (protected, limit 3); rectum: 16.4 nTPM (protected, limit 3); colon: 13.5 nTPM (protected, limit 3); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 3); heart muscle: 5.1 nTPM (vital, limit 1); stomach: 4.9 nTPM (protected, limit 3); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100526,CDKN3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.218753,0.178295,0.0753509,0,80,unavailable,42.3,27.7,30.2,"bone marrow: 42.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); lymph node: 27.7 nTPM (protected, limit 3); rectum: 16.4 nTPM (protected, limit 3); colon: 13.5 nTPM (protected, limit 3); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 3); heart muscle: 5.1 nTPM (vital, limit 1); stomach: 4.9 nTPM (protected, limit 3); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100526,CDKN3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.218753,0.178295,0.0753509,0,80,unavailable,42.3,27.7,30.2,"bone marrow: 42.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); lymph node: 27.7 nTPM (protected, limit 3); rectum: 16.4 nTPM (protected, limit 3); colon: 13.5 nTPM (protected, limit 3); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 3); heart muscle: 5.1 nTPM (vital, limit 1); stomach: 4.9 nTPM (protected, limit 3); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100526,CDKN3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.00522388,0.03,0.01,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100565,LRRC74A,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.305224,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100565,LRRC74A,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.305224,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100565,LRRC74A,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.305224,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100565,LRRC74A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.305224,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100565,LRRC74A,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.7055% (minimum 99%, Missing); amygdala: 94.5455% (minimum 99%, Missing); basal ganglia: 90.6977% (minimum 99%, Missing); bone marrow: 95.7055% (minimum 99%, Missing); cerebellum: 98.7342% (minimum 99%, Missing); cerebral cortex: 90.6977% (minimum 99%, Missing); choroid plexus: 83.8710% (minimum 99%, Missing); duodenum: 98.1132% (minimum 99%, Missing); hippocampal formation: 93.9759% (minimum 99%, Missing); hypothalamus: 91.2281% (minimum 99%, Missing); kidney: 89.6552% (minimum 99%, Missing); lung: 95.7055% (minimum 99%, Missing); lymph node: 91.7647% (minimum 97%, Missing); midbrain: 95.7055% (minimum 99%, Missing); pancreas: 89.1429% (minimum 99%, Missing); parathyroid gland: 87.1508% (minimum 97%, Missing); pituitary gland: 86.6667% (minimum 99%, Missing); retina: 51.8272% (minimum 99%, Missing); skeletal muscle: 98.7342% (minimum 99%, Missing); small intestine: 98.7342% (minimum 99%, Missing); smooth muscle: 98.1132% (minimum 99%, Missing); spinal cord: 97.5000% (minimum 99%, Missing); thyroid gland: 81.2500% (minimum 95%, Missing); urinary bladder: 95.1220% (minimum 97%, Missing)",-0.1375,-0.0984916,-0.471728,0,0,routine_complete,14.5,2.3,3.6,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100583,SAMD15,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 51.8272% (minimum 75%, Missing)",0.1625,0.171508,-0.231728,0,0,routine_complete,14.5,2.3,3.6,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100583,SAMD15,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 51.8272% (minimum 75%, Missing)",0.1625,0.171508,-0.231728,0,0,routine_complete,14.5,2.3,3.6,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100583,SAMD15,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 51.8272% (minimum 75%, Missing)",0.1625,0.171508,-0.231728,0,0,routine_complete,14.5,2.3,3.6,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100583,SAMD15,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 51.8272% (minimum 75%, Baseline (adaptation disabled))",0.1625,0.171508,-0.231728,0,0,routine_complete,14.5,2.3,3.6,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100583,SAMD15,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.9918% (minimum 99%, Missing)",0.05,0.029031,-8.16131e-05,0,3,partial,2.1,0.4,0.6,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100593,ISM2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.299031,0.239918,0,3,partial,2.1,0.4,0.6,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100593,ISM2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.299031,0.239918,0,3,partial,2.1,0.4,0.6,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100593,ISM2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.299031,0.239918,0,3,partial,2.1,0.4,0.6,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100593,ISM2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347099,0.298064,0.239918,0,3,partial,2.1,0.4,0.6,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100593,ISM2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Missing); adrenal gland: 86.2069% (minimum 99%, Missing); amygdala: 87.7193% (minimum 99%, Missing); basal ganglia: 87.7193% (minimum 99%, Missing); bone marrow: 45.0450% (minimum 99%, Missing); cerebellum: 87.7193% (minimum 99%, Missing); cerebral cortex: 86.2069% (minimum 99%, Missing); choroid plexus: 87.7193% (minimum 99%, Missing); colon: 72.4638% (minimum 97%, Missing); duodenum: 78.1250% (minimum 99%, Missing); esophagus: 75.7576% (minimum 97%, Missing); heart muscle: 80.6452% (minimum 99%, Missing); hippocampal formation: 86.2069% (minimum 99%, Missing); hypothalamus: 89.2857% (minimum 99%, Missing); kidney: 86.2069% (minimum 99%, Missing); liver: 84.7458% (minimum 99%, Uncertain); lung: 78.1250% (minimum 99%, Missing); lymph node: 52.0833% (minimum 97%, Missing); midbrain: 86.2069% (minimum 99%, Missing); pancreas: 89.2857% (minimum 99%, Missing); parathyroid gland: 75.7576% (minimum 97%, Missing); pituitary gland: 84.7458% (minimum 99%, Missing); rectum: 75.7576% (minimum 97%, Missing); retina: 76.9231% (minimum 99%, Missing); salivary gland: 74.6269% (minimum 97%, Missing); skeletal muscle: 73.5294% (minimum 99%, Missing); skin: 68.4932% (minimum 95%, Missing); small intestine: 83.3333% (minimum 99%, Missing); smooth muscle: 72.4638% (minimum 99%, Missing); spinal cord: 83.3333% (minimum 99%, Missing); spleen: 68.4932% (minimum 95%, Uncertain); stomach: 75.7576% (minimum 97%, Missing); thymus: 17.1233% (minimum 95%, Missing); thyroid gland: 75.7576% (minimum 95%, Missing); tongue: 84.7458% (minimum 97%, Missing); urinary bladder: 69.4444% (minimum 97%, Missing)",-0.778767,-0.449167,-0.53955,0,0,routine_complete,6.1,4.6,24.2,"thymus: 24.2 nTPM (manageable, limit 5); bone marrow: 6.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100629,CEP128,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 45.0450% (minimum 75%, Missing); lymph node: 52.0833% (minimum 70%, Missing); skeletal muscle: 73.5294% (minimum 75%, Missing); smooth muscle: 72.4638% (minimum 75%, Missing); thymus: 17.1233% (minimum 65%, Missing); urinary bladder: 69.4444% (minimum 70%, Missing)",-0.478767,-0.179167,-0.29955,0,0,routine_complete,6.1,4.6,24.2,"thymus: 24.2 nTPM (manageable, limit 5); bone marrow: 6.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100629,CEP128,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 45.0450% (minimum 75%, Missing); lymph node: 52.0833% (minimum 70%, Missing); skeletal muscle: 73.5294% (minimum 75%, Missing); smooth muscle: 72.4638% (minimum 75%, Missing); thymus: 17.1233% (minimum 65%, Missing); urinary bladder: 69.4444% (minimum 70%, Missing)",-0.478767,-0.179167,-0.29955,0,0,routine_complete,6.1,4.6,24.2,"thymus: 24.2 nTPM (manageable, limit 5); bone marrow: 6.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 3); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100629,CEP128,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 45.0450% (minimum 75%, Missing); lymph node: 52.0833% (minimum 70%, Missing); skeletal muscle: 73.5294% (minimum 75%, Missing); smooth muscle: 72.4638% (minimum 75%, Missing); thymus: 17.1233% (minimum 65%, Missing); urinary bladder: 69.4444% (minimum 70%, Missing)",-0.478767,-0.179167,-0.29955,0,0,routine_complete,6.1,4.6,24.2,"thymus: 24.2 nTPM (manageable, limit 5); bone marrow: 6.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 3); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100629,CEP128,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 45.0450% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.0833% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 73.5294% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.4638% (minimum 75%, Baseline (adaptation disabled)); thymus: 17.1233% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 69.4444% (minimum 70%, Baseline (adaptation disabled))",-0.478767,-0.179167,-0.29955,0,0,routine_complete,6.1,4.6,24.2,"thymus: 24.2 nTPM (manageable, limit 5); bone marrow: 6.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 3); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100629,CEP128,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0733% (minimum 95%, Missing); adrenal gland: 49.8480% (minimum 99%, Missing); amygdala: 58.9928% (minimum 99%, Missing); basal ganglia: 56.3574% (minimum 99%, Missing); bone marrow: 57.7465% (minimum 99%, Missing); cerebellum: 69.1983% (minimum 99%, Missing); cerebral cortex: 59.6364% (minimum 99%, Missing); choroid plexus: 41.8367% (minimum 99%, Missing); colon: 45.9384% (minimum 97%, Missing); duodenum: 52.3962% (minimum 99%, Missing); esophagus: 46.8571% (minimum 97%, Missing); heart muscle: 55.2189% (minimum 99%, Missing); hippocampal formation: 61.1940% (minimum 99%, Missing); hypothalamus: 61.4232% (minimum 99%, Missing); kidney: 40.5941% (minimum 99%, Missing); liver: 40.4938% (minimum 99%, Missing); lung: 57.5439% (minimum 99%, Missing); lymph node: 44.2049% (minimum 97%, Missing); midbrain: 55.2189% (minimum 99%, Missing); pancreas: 61.4232% (minimum 99%, Missing); parathyroid gland: 46.8571% (minimum 97%, Missing); pituitary gland: 63.5659% (minimum 99%, Missing); rectum: 44.9315% (minimum 97%, Missing); retina: 73.2143% (minimum 99%, Missing); salivary gland: 56.3574% (minimum 97%, Missing); skeletal muscle: 52.9032% (minimum 98%, Approved); skin: 49.3976% (minimum 95%, Missing); small intestine: 53.7705% (minimum 99%, Missing); smooth muscle: 58.9928% (minimum 99%, Missing); spinal cord: 52.2293% (minimum 99%, Missing); spleen: 55.4054% (minimum 90%, Approved); stomach: 55.2189% (minimum 97%, Missing); thymus: 35.1931% (minimum 95%, Missing); thyroid gland: 52.0635% (minimum 95%, Missing); tongue: 49.8480% (minimum 97%, Missing); urinary bladder: 52.5641% (minimum 97%, Missing)",-0.598069,-0.527951,-0.585062,0,6,partial,24.1,20.7,30.2,"thymus: 30.2 nTPM (manageable, limit 5); liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); rectum: 20.1 nTPM (protected, limit 2); colon: 19.3 nTPM (protected, limit 2); parathyroid gland: 18.6 nTPM (protected, limit 2); esophagus: 18.6 nTPM (protected, limit 2); skin: 16.8 nTPM (manageable, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); tongue: 16.5 nTPM (protected, limit 2); thyroid gland: 15.1 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 2); small intestine: 14.1 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); midbrain: 13.3 nTPM (vital, limit 1); heart muscle: 13.3 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 10); salivary gland: 12.7 nTPM (protected, limit 2); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100890,PRORP,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0733% (minimum 65%, Missing); adrenal gland: 49.8480% (minimum 75%, Missing); amygdala: 58.9928% (minimum 75%, Missing); basal ganglia: 56.3574% (minimum 75%, Missing); bone marrow: 57.7465% (minimum 75%, Missing); cerebellum: 69.1983% (minimum 75%, Missing); cerebral cortex: 59.6364% (minimum 75%, Missing); choroid plexus: 41.8367% (minimum 75%, Missing); colon: 45.9384% (minimum 70%, Missing); duodenum: 52.3962% (minimum 75%, Missing); esophagus: 46.8571% (minimum 70%, Missing); heart muscle: 55.2189% (minimum 75%, Missing); hippocampal formation: 61.1940% (minimum 75%, Missing); hypothalamus: 61.4232% (minimum 75%, Missing); kidney: 40.5941% (minimum 75%, Missing); liver: 40.4938% (minimum 75%, Missing); lung: 57.5439% (minimum 75%, Missing); lymph node: 44.2049% (minimum 70%, Missing); midbrain: 55.2189% (minimum 75%, Missing); pancreas: 61.4232% (minimum 75%, Missing); parathyroid gland: 46.8571% (minimum 70%, Missing); pituitary gland: 63.5659% (minimum 75%, Missing); rectum: 44.9315% (minimum 70%, Missing); retina: 73.2143% (minimum 75%, Missing); salivary gland: 56.3574% (minimum 70%, Missing); skeletal muscle: 52.9032% (minimum 70%, Approved); skin: 49.3976% (minimum 65%, Missing); small intestine: 53.7705% (minimum 75%, Missing); smooth muscle: 58.9928% (minimum 75%, Missing); spinal cord: 52.2293% (minimum 75%, Missing); spleen: 55.4054% (minimum 60%, Approved); stomach: 55.2189% (minimum 70%, Missing); thymus: 35.1931% (minimum 65%, Missing); thyroid gland: 52.0635% (minimum 65%, Missing); tongue: 49.8480% (minimum 70%, Missing); urinary bladder: 52.5641% (minimum 70%, Missing)",-0.298069,-0.257951,-0.345062,0,6,partial,24.1,20.7,30.2,"thymus: 30.2 nTPM (manageable, limit 5); liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); rectum: 20.1 nTPM (protected, limit 2); colon: 19.3 nTPM (protected, limit 2); parathyroid gland: 18.6 nTPM (protected, limit 2); esophagus: 18.6 nTPM (protected, limit 2); skin: 16.8 nTPM (manageable, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); tongue: 16.5 nTPM (protected, limit 2); thyroid gland: 15.1 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 2); small intestine: 14.1 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); midbrain: 13.3 nTPM (vital, limit 1); heart muscle: 13.3 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 10); salivary gland: 12.7 nTPM (protected, limit 2); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100890,PRORP,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0733% (minimum 65%, Missing); adrenal gland: 49.8480% (minimum 75%, Missing); amygdala: 58.9928% (minimum 75%, Missing); basal ganglia: 56.3574% (minimum 75%, Missing); bone marrow: 57.7465% (minimum 75%, Missing); cerebellum: 69.1983% (minimum 75%, Missing); cerebral cortex: 59.6364% (minimum 75%, Missing); choroid plexus: 41.8367% (minimum 75%, Missing); colon: 45.9384% (minimum 70%, Missing); duodenum: 52.3962% (minimum 75%, Missing); esophagus: 46.8571% (minimum 70%, Missing); heart muscle: 55.2189% (minimum 75%, Missing); hippocampal formation: 61.1940% (minimum 75%, Missing); hypothalamus: 61.4232% (minimum 75%, Missing); kidney: 40.5941% (minimum 75%, Missing); liver: 40.4938% (minimum 75%, Missing); lung: 57.5439% (minimum 75%, Missing); lymph node: 44.2049% (minimum 70%, Missing); midbrain: 55.2189% (minimum 75%, Missing); pancreas: 61.4232% (minimum 75%, Missing); parathyroid gland: 46.8571% (minimum 70%, Missing); pituitary gland: 63.5659% (minimum 75%, Missing); rectum: 44.9315% (minimum 70%, Missing); retina: 73.2143% (minimum 75%, Missing); salivary gland: 56.3574% (minimum 70%, Missing); skeletal muscle: 52.9032% (minimum 70%, Approved); skin: 49.3976% (minimum 65%, Missing); small intestine: 53.7705% (minimum 75%, Missing); smooth muscle: 58.9928% (minimum 75%, Missing); spinal cord: 52.2293% (minimum 75%, Missing); spleen: 55.4054% (minimum 60%, Approved); stomach: 55.2189% (minimum 70%, Missing); thymus: 35.1931% (minimum 65%, Missing); thyroid gland: 52.0635% (minimum 65%, Missing); tongue: 49.8480% (minimum 70%, Missing); urinary bladder: 52.5641% (minimum 70%, Missing)",-0.298069,-0.257951,-0.345062,0,6,partial,24.1,20.7,30.2,"thymus: 30.2 nTPM (manageable, limit 5); liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 3); rectum: 20.1 nTPM (protected, limit 3); colon: 19.3 nTPM (protected, limit 3); parathyroid gland: 18.6 nTPM (protected, limit 3); esophagus: 18.6 nTPM (protected, limit 3); skin: 16.8 nTPM (manageable, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); tongue: 16.5 nTPM (protected, limit 3); thyroid gland: 15.1 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 3); skeletal muscle: 14.6 nTPM (vital, limit 2); small intestine: 14.1 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); midbrain: 13.3 nTPM (vital, limit 1); heart muscle: 13.3 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 10); salivary gland: 12.7 nTPM (protected, limit 3); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100890,PRORP,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0733% (minimum 65%, Missing); adrenal gland: 49.8480% (minimum 75%, Missing); amygdala: 58.9928% (minimum 75%, Missing); basal ganglia: 56.3574% (minimum 75%, Missing); bone marrow: 57.7465% (minimum 75%, Missing); cerebellum: 69.1983% (minimum 75%, Missing); cerebral cortex: 59.6364% (minimum 75%, Missing); choroid plexus: 41.8367% (minimum 75%, Missing); colon: 45.9384% (minimum 70%, Missing); duodenum: 52.3962% (minimum 75%, Missing); esophagus: 46.8571% (minimum 70%, Missing); heart muscle: 55.2189% (minimum 75%, Missing); hippocampal formation: 61.1940% (minimum 75%, Missing); hypothalamus: 61.4232% (minimum 75%, Missing); kidney: 40.5941% (minimum 75%, Missing); liver: 40.4938% (minimum 75%, Missing); lung: 57.5439% (minimum 75%, Missing); lymph node: 44.2049% (minimum 70%, Missing); midbrain: 55.2189% (minimum 75%, Missing); pancreas: 61.4232% (minimum 75%, Missing); parathyroid gland: 46.8571% (minimum 70%, Missing); pituitary gland: 63.5659% (minimum 75%, Missing); rectum: 44.9315% (minimum 70%, Missing); retina: 73.2143% (minimum 75%, Missing); salivary gland: 56.3574% (minimum 70%, Missing); skeletal muscle: 52.9032% (minimum 70%, Approved); skin: 49.3976% (minimum 65%, Missing); small intestine: 53.7705% (minimum 75%, Missing); smooth muscle: 58.9928% (minimum 75%, Missing); spinal cord: 52.2293% (minimum 75%, Missing); spleen: 55.4054% (minimum 60%, Approved); stomach: 55.2189% (minimum 70%, Missing); thymus: 35.1931% (minimum 65%, Missing); thyroid gland: 52.0635% (minimum 65%, Missing); tongue: 49.8480% (minimum 70%, Missing); urinary bladder: 52.5641% (minimum 70%, Missing)",-0.298069,-0.257951,-0.345062,0,6,partial,24.1,20.7,30.2,"thymus: 30.2 nTPM (manageable, limit 5); liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 3); rectum: 20.1 nTPM (protected, limit 3); colon: 19.3 nTPM (protected, limit 3); parathyroid gland: 18.6 nTPM (protected, limit 3); esophagus: 18.6 nTPM (protected, limit 3); skin: 16.8 nTPM (manageable, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); tongue: 16.5 nTPM (protected, limit 3); thyroid gland: 15.1 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 3); skeletal muscle: 14.6 nTPM (vital, limit 2); small intestine: 14.1 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); midbrain: 13.3 nTPM (vital, limit 1); heart muscle: 13.3 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 10); salivary gland: 12.7 nTPM (protected, limit 3); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100890,PRORP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0733% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 49.8480% (minimum 75%, Baseline (adaptation disabled)); amygdala: 58.9928% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.3574% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 57.7465% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 69.1983% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 59.6364% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 41.8367% (minimum 75%, Baseline (adaptation disabled)); colon: 45.9384% (minimum 70%, Baseline (adaptation disabled)); duodenum: 52.3962% (minimum 75%, Baseline (adaptation disabled)); esophagus: 46.8571% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 55.2189% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.1940% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.4232% (minimum 75%, Baseline (adaptation disabled)); kidney: 40.5941% (minimum 75%, Baseline (adaptation disabled)); liver: 40.4938% (minimum 75%, Baseline (adaptation disabled)); lung: 57.5439% (minimum 75%, Baseline (adaptation disabled)); lymph node: 44.2049% (minimum 70%, Baseline (adaptation disabled)); midbrain: 55.2189% (minimum 75%, Baseline (adaptation disabled)); pancreas: 61.4232% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 46.8571% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.5659% (minimum 75%, Baseline (adaptation disabled)); rectum: 44.9315% (minimum 70%, Baseline (adaptation disabled)); retina: 73.2143% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.3574% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 52.9032% (minimum 75%, Baseline (adaptation disabled)); skin: 49.3976% (minimum 65%, Baseline (adaptation disabled)); small intestine: 53.7705% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.9928% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 52.2293% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.4054% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.2189% (minimum 70%, Baseline (adaptation disabled)); thymus: 35.1931% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.0635% (minimum 65%, Baseline (adaptation disabled)); tongue: 49.8480% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.5641% (minimum 70%, Baseline (adaptation disabled))",-0.298069,-0.257951,-0.345062,0,6,partial,24.1,20.7,30.2,"thymus: 30.2 nTPM (manageable, limit 5); liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 3); rectum: 20.1 nTPM (protected, limit 3); colon: 19.3 nTPM (protected, limit 3); parathyroid gland: 18.6 nTPM (protected, limit 3); esophagus: 18.6 nTPM (protected, limit 3); skin: 16.8 nTPM (manageable, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); tongue: 16.5 nTPM (protected, limit 3); thyroid gland: 15.1 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 3); skeletal muscle: 14.6 nTPM (vital, limit 1); small intestine: 14.1 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); midbrain: 13.3 nTPM (vital, limit 1); heart muscle: 13.3 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); salivary gland: 12.7 nTPM (protected, limit 3); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000100890,PRORP,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Uncertain); adrenal gland: 93.6170% (minimum 99%, Missing); amygdala: 90.7216% (minimum 99%, Missing); basal ganglia: 90.7216% (minimum 99%, Missing); bone marrow: 69.8413% (minimum 99%, Missing); cerebellum: 73.9496% (minimum 99%, Missing); cerebral cortex: 87.1287% (minimum 99%, Missing); choroid plexus: 98.8764% (minimum 99%, Missing); colon: 72.7273% (minimum 97%, Missing); duodenum: 75.2137% (minimum 99%, Missing); esophagus: 68.2171% (minimum 97%, Missing); heart muscle: 94.6237% (minimum 99%, Uncertain); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 91.6667% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 88.0000% (minimum 99%, Missing); lung: 94.6237% (minimum 99%, Missing); lymph node: 63.7681% (minimum 97%, Missing); midbrain: 93.6170% (minimum 99%, Missing); pancreas: 95.6522% (minimum 99%, Missing); parathyroid gland: 95.6522% (minimum 97%, Uncertain); pituitary gland: 97.7778% (minimum 99%, Missing); rectum: 72.1311% (minimum 97%, Missing); retina: 91.6667% (minimum 99%, Missing); salivary gland: 91.6667% (minimum 97%, Uncertain); skeletal muscle: 96.7033% (minimum 99%, Uncertain); skin: 72.1311% (minimum 95%, Uncertain); small intestine: 75.8621% (minimum 99%, Missing); smooth muscle: 83.8095% (minimum 99%, Uncertain); spinal cord: 93.6170% (minimum 99%, Missing); spleen: 86.2745% (minimum 95%, Missing); stomach: 82.2430% (minimum 97%, Missing); thymus: 55.3459% (minimum 95%, Missing); thyroid gland: 93.6170% (minimum 95%, Missing); urinary bladder: 88.0000% (minimum 97%, Missing)",-0.396541,-0.332319,-0.291587,0,6,partial,3.8,5,7.1,"thymus: 7.1 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 3.8 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101003,GINS1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.8413% (minimum 75%, Missing); cerebellum: 73.9496% (minimum 75%, Missing); esophagus: 68.2171% (minimum 70%, Missing); lymph node: 63.7681% (minimum 70%, Missing); thymus: 55.3459% (minimum 65%, Missing)",-0.0965409,-0.0623188,-0.0515873,0,6,partial,3.8,5,7.1,"thymus: 7.1 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 3.8 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101003,GINS1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.8413% (minimum 75%, Missing); cerebellum: 73.9496% (minimum 75%, Missing); esophagus: 68.2171% (minimum 70%, Missing); lymph node: 63.7681% (minimum 70%, Missing); thymus: 55.3459% (minimum 65%, Missing)",-0.0965409,-0.0623188,-0.0515873,0,6,partial,3.8,5,7.1,"thymus: 7.1 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 3.8 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101003,GINS1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.8413% (minimum 75%, Missing); cerebellum: 73.9496% (minimum 75%, Missing); esophagus: 68.2171% (minimum 70%, Missing); lymph node: 63.7681% (minimum 70%, Missing); thymus: 55.3459% (minimum 65%, Missing)",-0.0965409,-0.0623188,-0.0515873,0,6,partial,3.8,5,7.1,"thymus: 7.1 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 3.8 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101003,GINS1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.8413% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.9496% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.2171% (minimum 70%, Baseline (adaptation disabled)); lymph node: 63.7681% (minimum 70%, Baseline (adaptation disabled)); thymus: 55.3459% (minimum 65%, Baseline (adaptation disabled))",-0.0965409,-0.0623188,-0.0515873,0,6,partial,3.8,5,7.1,"thymus: 7.1 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 3.8 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101003,GINS1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.4192% (minimum 95%, Missing); adrenal gland: 96.1783% (minimum 99%, Missing); bone marrow: 14.2857% (minimum 99%, Missing); cerebral cortex: 96.7949% (minimum 99%, Missing); choroid plexus: 94.9686% (minimum 99%, Missing); colon: 64.5299% (minimum 97%, Missing); duodenum: 68.9498% (minimum 99%, Missing); esophagus: 60.6426% (minimum 97%, Missing); heart muscle: 97.4194% (minimum 99%, Missing); kidney: 96.1783% (minimum 99%, Missing); liver: 93.2099% (minimum 99%, Missing); lung: 89.8810% (minimum 99%, Missing); lymph node: 21.7893% (minimum 97%, Missing); pancreas: 58.0769% (minimum 99%, Missing); pituitary gland: 98.6928% (minimum 99%, Missing); rectum: 69.2661% (minimum 97%, Missing); salivary gland: 90.9639% (minimum 97%, Missing); skin: 78.6458% (minimum 95%, Missing); small intestine: 66.5198% (minimum 99%, Missing); smooth muscle: 88.3041% (minimum 99%, Missing); spleen: 35.6974% (minimum 95%, Missing); stomach: 71.9048% (minimum 97%, Missing); thymus: 31.7895% (minimum 95%, Missing); urinary bladder: 81.6216% (minimum 97%, Missing)",-0.632105,-0.752107,-0.847143,0,1,partial,90.6,54.2,32.4,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 2); thymus: 32.4 nTPM (manageable, limit 5); spleen: 27.2 nTPM (manageable, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); stomach: 5.9 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101057,MYBL2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 14.2857% (minimum 75%, Missing); colon: 64.5299% (minimum 70%, Missing); duodenum: 68.9498% (minimum 75%, Missing); esophagus: 60.6426% (minimum 70%, Missing); lymph node: 21.7893% (minimum 70%, Missing); pancreas: 58.0769% (minimum 75%, Missing); rectum: 69.2661% (minimum 70%, Missing); small intestine: 66.5198% (minimum 75%, Missing); spleen: 35.6974% (minimum 65%, Missing); thymus: 31.7895% (minimum 65%, Missing)",-0.332105,-0.482107,-0.607143,0,1,partial,90.6,54.2,32.4,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 2); thymus: 32.4 nTPM (manageable, limit 5); spleen: 27.2 nTPM (manageable, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); stomach: 5.9 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101057,MYBL2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 14.2857% (minimum 75%, Missing); colon: 64.5299% (minimum 70%, Missing); duodenum: 68.9498% (minimum 75%, Missing); esophagus: 60.6426% (minimum 70%, Missing); lymph node: 21.7893% (minimum 70%, Missing); pancreas: 58.0769% (minimum 75%, Missing); rectum: 69.2661% (minimum 70%, Missing); small intestine: 66.5198% (minimum 75%, Missing); spleen: 35.6974% (minimum 65%, Missing); thymus: 31.7895% (minimum 65%, Missing)",-0.332105,-0.482107,-0.607143,0,1,partial,90.6,54.2,32.4,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 3); thymus: 32.4 nTPM (manageable, limit 5); spleen: 27.2 nTPM (manageable, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 3); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); stomach: 5.9 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101057,MYBL2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 14.2857% (minimum 75%, Missing); colon: 64.5299% (minimum 70%, Missing); duodenum: 68.9498% (minimum 75%, Missing); esophagus: 60.6426% (minimum 70%, Missing); lymph node: 21.7893% (minimum 70%, Missing); pancreas: 58.0769% (minimum 75%, Missing); rectum: 69.2661% (minimum 70%, Missing); small intestine: 66.5198% (minimum 75%, Missing); spleen: 35.6974% (minimum 65%, Missing); thymus: 31.7895% (minimum 65%, Missing)",-0.332105,-0.482107,-0.607143,0,1,partial,90.6,54.2,32.4,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 3); thymus: 32.4 nTPM (manageable, limit 5); spleen: 27.2 nTPM (manageable, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 3); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); stomach: 5.9 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101057,MYBL2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 14.2857% (minimum 75%, Baseline (adaptation disabled)); colon: 64.5299% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.9498% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.6426% (minimum 70%, Baseline (adaptation disabled)); lymph node: 21.7893% (minimum 70%, Baseline (adaptation disabled)); pancreas: 58.0769% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.2661% (minimum 70%, Baseline (adaptation disabled)); small intestine: 66.5198% (minimum 75%, Baseline (adaptation disabled)); spleen: 35.6974% (minimum 65%, Baseline (adaptation disabled)); thymus: 31.7895% (minimum 65%, Baseline (adaptation disabled))",-0.332105,-0.482107,-0.607143,0,1,partial,90.6,54.2,32.4,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 3); thymus: 32.4 nTPM (manageable, limit 5); spleen: 27.2 nTPM (manageable, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 3); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); stomach: 5.9 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101057,MYBL2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 80.0000% (minimum 95%, Enhanced); colon: 36.3636% (minimum 97%, Missing); duodenum: 16.0000% (minimum 99%, Missing); hypothalamus: 57.1429% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 80.0000% (minimum 95%, Enhanced); lung: 80.0000% (minimum 95%, Enhanced); retina: 80.0000% (minimum 99%, Missing); small intestine: 14.8148% (minimum 99%, Missing); stomach: 50.0000% (minimum 80%, Enhanced)",0.05,-0.606364,-0.841852,0,9,partial,2.3,0.7,0.1,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),75,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; appendix / goblet cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101074,R3HDML,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 36.3636% (minimum 70%, Missing); duodenum: 16.0000% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); small intestine: 14.8148% (minimum 75%, Missing); stomach: 50.0000% (minimum 55%, Enhanced)",0.3,-0.336364,-0.601852,0,9,partial,2.3,0.7,0.1,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),75,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; appendix / goblet cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101074,R3HDML,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 36.3636% (minimum 70%, Missing); duodenum: 16.0000% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); small intestine: 14.8148% (minimum 75%, Missing); stomach: 50.0000% (minimum 55%, Enhanced)",0.3,-0.336364,-0.601852,0,9,partial,2.3,0.7,0.1,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),75,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; appendix / goblet cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101074,R3HDML,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 36.3636% (minimum 70%, Missing); duodenum: 16.0000% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); small intestine: 14.8148% (minimum 75%, Missing); stomach: 50.0000% (minimum 55%, Enhanced)",0.3,-0.336364,-0.601852,0,9,partial,2.3,0.7,0.1,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),75,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; appendix / goblet cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101074,R3HDML,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 36.3636% (minimum 70%, Baseline (adaptation disabled)); duodenum: 16.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 57.1429% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); small intestine: 14.8148% (minimum 75%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 70%, Baseline (adaptation disabled))",0.15,-0.336364,-0.601852,0,9,partial,2.3,0.7,0.1,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),75,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; appendix / goblet cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101074,R3HDML,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.0000% (minimum 99%, Missing); amygdala: 24.2424% (minimum 99%, Missing); basal ganglia: 35.8209% (minimum 99%, Missing); cerebellum: 55.8140% (minimum 99%, Missing); cerebral cortex: 21.0526% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); hippocampal formation: 28.5714% (minimum 99%, Missing); hypothalamus: 42.8571% (minimum 99%, Missing); kidney: 96.0000% (minimum 99%, Missing); midbrain: 32.4324% (minimum 99%, Missing); pituitary gland: 70.5882% (minimum 99%, Missing); retina: 96.0000% (minimum 99%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); skeletal muscle: 96.0000% (minimum 99%, Missing); spinal cord: 36.3636% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); tongue: 92.3077% (minimum 97%, Missing)",-0.15,-0.0469231,-0.779474,0,80,unavailable,9,0.2,0.6,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101203,COL20A1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 24.2424% (minimum 75%, Missing); basal ganglia: 35.8209% (minimum 75%, Missing); cerebellum: 55.8140% (minimum 75%, Missing); cerebral cortex: 21.0526% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); hippocampal formation: 28.5714% (minimum 75%, Missing); hypothalamus: 42.8571% (minimum 75%, Missing); midbrain: 32.4324% (minimum 75%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); spinal cord: 36.3636% (minimum 75%, Missing)",0.15,0.223077,-0.539474,0,80,unavailable,9,0.2,0.6,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101203,COL20A1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 24.2424% (minimum 75%, Missing); basal ganglia: 35.8209% (minimum 75%, Missing); cerebellum: 55.8140% (minimum 75%, Missing); cerebral cortex: 21.0526% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); hippocampal formation: 28.5714% (minimum 75%, Missing); hypothalamus: 42.8571% (minimum 75%, Missing); midbrain: 32.4324% (minimum 75%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); spinal cord: 36.3636% (minimum 75%, Missing)",0.15,0.223077,-0.539474,0,80,unavailable,9,0.2,0.6,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101203,COL20A1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 24.2424% (minimum 75%, Missing); basal ganglia: 35.8209% (minimum 75%, Missing); cerebellum: 55.8140% (minimum 75%, Missing); cerebral cortex: 21.0526% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); hippocampal formation: 28.5714% (minimum 75%, Missing); hypothalamus: 42.8571% (minimum 75%, Missing); midbrain: 32.4324% (minimum 75%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); spinal cord: 36.3636% (minimum 75%, Missing)",0.15,0.223077,-0.539474,0,80,unavailable,9,0.2,0.6,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101203,COL20A1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 24.2424% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 35.8209% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.8140% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 21.0526% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 28.5714% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 42.8571% (minimum 75%, Baseline (adaptation disabled)); midbrain: 32.4324% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 70.5882% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 36.3636% (minimum 75%, Baseline (adaptation disabled))",0.15,0.223077,-0.539474,0,80,unavailable,9,0.2,0.6,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101203,COL20A1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"spinal cord: 98.5714% (minimum 99%, Missing)",0.05,0.03,-0.00428571,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101251,SEL1L2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235714,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101251,SEL1L2,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235714,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101251,SEL1L2,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235714,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101251,SEL1L2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235714,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101251,SEL1L2,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 89.7260% (minimum 99%, Missing); basal ganglia: 87.9195% (minimum 99%, Missing); cerebellum: 94.6988% (minimum 99%, Missing); cerebral cortex: 88.9140% (minimum 99%, Missing); choroid plexus: 97.7612% (minimum 99%, Missing); colon: 77.9762% (minimum 95%, Approved); duodenum: 73.8722% (minimum 99%, Missing); esophagus: 88.7133% (minimum 97%, Missing); heart muscle: 86.9469% (minimum 98%, Approved); hippocampal formation: 88.3146% (minimum 99%, Missing); hypothalamus: 88.7133% (minimum 99%, Missing); kidney: 79.3939% (minimum 99%, Missing); lung: 97.0370% (minimum 98%, Approved); midbrain: 85.9956% (minimum 99%, Missing); pancreas: 96.0880% (minimum 98%, Approved); rectum: 85.0649% (minimum 97%, Missing); retina: 98.4962% (minimum 99%, Missing); salivary gland: 86.9469% (minimum 97%, Missing); small intestine: 67.8756% (minimum 99%, Missing); smooth muscle: 96.0880% (minimum 98%, Approved); spinal cord: 87.9195% (minimum 99%, Missing); stomach: 87.9195% (minimum 97%, Missing); urinary bladder: 89.3182% (minimum 97%, Missing)",0.0349624,-0.170238,-0.311244,0,1,partial,18.6,11.1,2.3,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 4); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); midbrain: 6.4 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 2); spinal cord: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); cerebral cortex: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101276,SLC52A3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 73.8722% (minimum 75%, Missing); small intestine: 67.8756% (minimum 75%, Missing)",0.334962,0.129762,-0.0712435,0,1,partial,18.6,11.1,2.3,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 4); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); midbrain: 6.4 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 2); spinal cord: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); cerebral cortex: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101276,SLC52A3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 73.8722% (minimum 75%, Missing); small intestine: 67.8756% (minimum 75%, Missing)",0.334962,0.129762,-0.0712435,0,1,partial,18.6,11.1,2.3,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 4); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 3); midbrain: 6.4 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 3); spinal cord: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); cerebral cortex: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101276,SLC52A3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 73.8722% (minimum 75%, Missing); small intestine: 67.8756% (minimum 75%, Missing)",0.334962,0.129762,-0.0712435,0,1,partial,18.6,11.1,2.3,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 4); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 3); midbrain: 6.4 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 3); spinal cord: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); cerebral cortex: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101276,SLC52A3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 73.8722% (minimum 75%, Baseline (adaptation disabled)); small intestine: 67.8756% (minimum 75%, Baseline (adaptation disabled))",0.294712,0.0797619,-0.0712435,0,1,partial,18.6,11.1,2.3,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 3); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 3); midbrain: 6.4 nTPM (vital, limit 1); salivary gland: 5.9 nTPM (protected, limit 3); heart muscle: 5.9 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); basal ganglia: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); hypothalamus: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101276,SLC52A3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.2990% (minimum 99%, Missing); amygdala: 95.7672% (minimum 99%, Missing); basal ganglia: 94.7644% (minimum 99%, Missing); bone marrow: 96.7914% (minimum 98%, Approved); cerebellum: 93.2990% (minimum 99%, Missing); cerebral cortex: 92.8205% (minimum 99%, Missing); choroid plexus: 86.6029% (minimum 99%, Missing); colon: 93.7824% (minimum 97%, Missing); duodenum: 95.7672% (minimum 99%, Missing); heart muscle: 89.6040% (minimum 99%, Missing); hippocampal formation: 96.2766% (minimum 99%, Missing); hypothalamus: 94.2708% (minimum 99%, Missing); kidney: 91.4141% (minimum 99%, Missing); liver: 90.9548% (minimum 98%, Approved); lung: 96.7914% (minimum 98%, Approved); lymph node: 93.7824% (minimum 95%, Approved); midbrain: 95.7672% (minimum 99%, Missing); pancreas: 91.8782% (minimum 98%, Approved); parathyroid gland: 91.8782% (minimum 95%, Approved); pituitary gland: 91.4141% (minimum 99%, Missing); retina: 82.2727% (minimum 99%, Missing); salivary gland: 94.7644% (minimum 97%, Missing); skeletal muscle: 76.3713% (minimum 98%, Approved); small intestine: 96.7914% (minimum 98%, Approved); smooth muscle: 90.5000% (minimum 98%, Approved); spinal cord: 96.2766% (minimum 99%, Missing); thymus: 92.8205% (minimum 95%, Missing); thyroid gland: 90.5000% (minimum 95%, Missing); tongue: 81.5315% (minimum 97%, Missing)",-0.045,-0.154685,-0.216287,0,1,partial,5.6,4.1,1.9,"skeletal muscle: 5.6 nTPM (vital, limit 2); tongue: 4.1 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101353,MROH8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.255,0.115315,0.0637131,0,1,partial,5.6,4.1,1.9,"skeletal muscle: 5.6 nTPM (vital, limit 2); tongue: 4.1 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101353,MROH8,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.255,0.115315,0.0637131,0,1,partial,5.6,4.1,1.9,"skeletal muscle: 5.6 nTPM (vital, limit 2); tongue: 4.1 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101353,MROH8,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.255,0.115315,0.0637131,0,1,partial,5.6,4.1,1.9,"skeletal muscle: 5.6 nTPM (vital, limit 2); tongue: 4.1 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101353,MROH8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.255,0.115315,0.0137131,0,1,partial,5.6,4.1,1.9,"skeletal muscle: 5.6 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101353,MROH8,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101435,CST9L,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101435,CST9L,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101435,CST9L,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101435,CST9L,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101435,CST9L,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"skin: 89.5652% (minimum 95%, Missing)",-0.0543478,0.03,0.01,0,8,partial,0,0,1.2,,skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced),66,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000101446,SPINT3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.245652,0.3,0.25,0,8,partial,0,0,1.2,,skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced),66,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000101446,SPINT3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.245652,0.3,0.25,0,8,partial,0,0,1.2,,skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced),66,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000101446,SPINT3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.245652,0.3,0.25,0,8,partial,0,0,1.2,,skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced),66,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000101446,SPINT3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.245652,0.3,0.25,0,8,partial,0,0,1.2,,skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced),66,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000101446,SPINT3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.0075039,0,1,partial,2.3,0.4,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101448,EPPIN,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247504,0,1,partial,2.3,0.4,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101448,EPPIN,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247504,0,1,partial,2.3,0.4,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101448,EPPIN,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247504,0,1,partial,2.3,0.4,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101448,EPPIN,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347815,0.29875,0.242857,0,1,partial,2.3,0.4,0.7,"bone marrow: 2.3 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101448,EPPIN,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 87.7698% (minimum 99%, Missing); amygdala: 63.8743% (minimum 99%, Missing); basal ganglia: 58.3732% (minimum 99%, Missing); cerebellum: 53.9823% (minimum 99%, Missing); cerebral cortex: 54.9550% (minimum 99%, Missing); choroid plexus: 96.0630% (minimum 99%, Missing); hippocampal formation: 68.5393% (minimum 99%, Missing); hypothalamus: 61.3065% (minimum 99%, Missing); kidney: 94.5736% (minimum 99%, Missing); liver: 85.3147% (minimum 99%, Missing); lung: 98.3871% (minimum 99%, Missing); midbrain: 81.8792% (minimum 99%, Missing); pancreas: 88.4058% (minimum 99%, Missing); pituitary gland: 61.0000% (minimum 99%, Missing); rectum: 94.5736% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); spinal cord: 89.0511% (minimum 99%, Missing); stomach: 94.5736% (minimum 97%, Missing); thyroid gland: 89.0511% (minimum 95%, Missing); urinary bladder: 96.0630% (minimum 97%, Missing)",-0.0594891,-0.0242636,-0.450177,0,80,unavailable,10.4,0.7,1.5,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101746,NOL4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 63.8743% (minimum 75%, Missing); basal ganglia: 58.3732% (minimum 75%, Missing); cerebellum: 53.9823% (minimum 75%, Missing); cerebral cortex: 54.9550% (minimum 75%, Missing); hippocampal formation: 68.5393% (minimum 75%, Missing); hypothalamus: 61.3065% (minimum 75%, Missing); pituitary gland: 61.0000% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.240511,0.245736,-0.210177,0,80,unavailable,10.4,0.7,1.5,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101746,NOL4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 63.8743% (minimum 75%, Missing); basal ganglia: 58.3732% (minimum 75%, Missing); cerebellum: 53.9823% (minimum 75%, Missing); cerebral cortex: 54.9550% (minimum 75%, Missing); hippocampal formation: 68.5393% (minimum 75%, Missing); hypothalamus: 61.3065% (minimum 75%, Missing); pituitary gland: 61.0000% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.240511,0.245736,-0.210177,0,80,unavailable,10.4,0.7,1.5,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101746,NOL4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 63.8743% (minimum 75%, Missing); basal ganglia: 58.3732% (minimum 75%, Missing); cerebellum: 53.9823% (minimum 75%, Missing); cerebral cortex: 54.9550% (minimum 75%, Missing); hippocampal formation: 68.5393% (minimum 75%, Missing); hypothalamus: 61.3065% (minimum 75%, Missing); pituitary gland: 61.0000% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.240511,0.245736,-0.210177,0,80,unavailable,10.4,0.7,1.5,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101746,NOL4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 63.8743% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.3732% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 53.9823% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 54.9550% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.5393% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.3065% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 61.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.240511,0.245736,-0.210177,0,80,unavailable,10.4,0.7,1.5,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101746,NOL4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 88.4615% (minimum 95%, Missing); adrenal gland: 88.4615% (minimum 99%, Missing); basal ganglia: 95.8333% (minimum 99%, Missing); bone marrow: 79.3103% (minimum 99%, Missing); cerebral cortex: 88.4615% (minimum 99%, Missing); choroid plexus: 82.1429% (minimum 99%, Missing); colon: 92.0000% (minimum 97%, Missing); duodenum: 92.0000% (minimum 99%, Missing); esophagus: 92.0000% (minimum 97%, Missing); heart muscle: 95.8333% (minimum 99%, Missing); kidney: 95.8333% (minimum 99%, Missing); lung: 92.0000% (minimum 99%, Missing); lymph node: 76.6667% (minimum 97%, Missing); parathyroid gland: 88.4615% (minimum 97%, Missing); rectum: 88.4615% (minimum 97%, Missing); retina: 76.6667% (minimum 99%, Missing); salivary gland: 88.4615% (minimum 97%, Missing); skeletal muscle: 92.0000% (minimum 99%, Missing); skin: 76.6667% (minimum 95%, Missing); small intestine: 92.0000% (minimum 99%, Missing); smooth muscle: 69.6970% (minimum 99%, Missing); spleen: 82.1429% (minimum 95%, Missing); stomach: 92.0000% (minimum 97%, Missing); thymus: 54.7619% (minimum 95%, Missing); tongue: 79.3103% (minimum 97%, Missing); urinary bladder: 85.1852% (minimum 97%, Missing)",-0.402381,-0.203333,-0.29303,0,80,unavailable,1,0.7,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000101812,H2BW2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"smooth muscle: 69.6970% (minimum 75%, Missing); thymus: 54.7619% (minimum 65%, Missing)",-0.102381,0.0666667,-0.0530303,0,80,unavailable,1,0.7,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000101812,H2BW2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"smooth muscle: 69.6970% (minimum 75%, Missing); thymus: 54.7619% (minimum 65%, Missing)",-0.102381,0.0666667,-0.0530303,0,80,unavailable,1,0.7,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000101812,H2BW2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"smooth muscle: 69.6970% (minimum 75%, Missing); thymus: 54.7619% (minimum 65%, Missing)",-0.102381,0.0666667,-0.0530303,0,80,unavailable,1,0.7,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000101812,H2BW2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"smooth muscle: 69.6970% (minimum 75%, Baseline (adaptation disabled)); thymus: 54.7619% (minimum 65%, Baseline (adaptation disabled))",-0.102381,0.0666667,-0.0530303,0,80,unavailable,1,0.7,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000101812,H2BW2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.2979% (minimum 99%, Missing); duodenum: 97.4684% (minimum 99%, Missing); pituitary gland: 94.8665% (minimum 99%, Missing); stomach: 19.6763% (minimum 97%, Missing); urinary bladder: 84.3066% (minimum 97%, Missing)",0.0350746,-0.773237,-0.0413347,0,4,partial,2.5,188.6,0.8,"stomach: 188.6 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101842,VSIG1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"stomach: 19.6763% (minimum 70%, Missing)",0.335075,-0.503237,0.198665,0,4,partial,2.5,188.6,0.8,"stomach: 188.6 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101842,VSIG1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"stomach: 19.6763% (minimum 70%, Missing)",0.335075,-0.503237,0.198665,0,4,partial,2.5,188.6,0.8,"stomach: 188.6 nTPM (protected, limit 3); urinary bladder: 8.6 nTPM (protected, limit 3); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101842,VSIG1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"stomach: 19.6763% (minimum 70%, Missing)",0.335075,-0.503237,0.198665,0,4,partial,2.5,188.6,0.8,"stomach: 188.6 nTPM (protected, limit 3); urinary bladder: 8.6 nTPM (protected, limit 3); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101842,VSIG1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"stomach: 19.6763% (minimum 70%, Baseline (adaptation disabled))",0.332979,-0.503237,0.198665,0,4,partial,2.5,188.6,0.8,"stomach: 188.6 nTPM (protected, limit 3); urinary bladder: 8.6 nTPM (protected, limit 3); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101842,VSIG1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.9936% (minimum 98%, Approved); amygdala: 89.5706% (minimum 99%, Missing); basal ganglia: 88.4848% (minimum 99%, Missing); cerebellum: 53.6765% (minimum 98%, Approved); cerebral cortex: 82.9545% (minimum 98%, Approved); choroid plexus: 79.3478% (minimum 99%, Missing); colon: 89.5706% (minimum 97%, Missing); heart muscle: 96.0526% (minimum 98%, Approved); hippocampal formation: 89.5706% (minimum 99%, Missing); hypothalamus: 79.7814% (minimum 99%, Missing); kidney: 89.5706% (minimum 98%, Approved); liver: 94.1935% (minimum 98%, Approved); lung: 96.6887% (minimum 98%, Approved); midbrain: 90.1235% (minimum 99%, Missing); pituitary gland: 89.5706% (minimum 99%, Missing); retina: 85.3801% (minimum 99%, Missing); small intestine: 93.5897% (minimum 98%, Approved); spinal cord: 92.4051% (minimum 99%, Missing); urinary bladder: 93.5897% (minimum 95%, Approved)",0.00123457,-0.0742945,-0.443235,0,2,partial,12.6,1.7,1.6,"cerebellum: 12.6 nTPM (vital, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101883,RHOXF1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 53.6765% (minimum 70%, Approved)",0.301235,0.195706,-0.163235,0,2,partial,12.6,1.7,1.6,"cerebellum: 12.6 nTPM (vital, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101883,RHOXF1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 53.6765% (minimum 70%, Approved)",0.301235,0.195706,-0.163235,0,2,partial,12.6,1.7,1.6,"cerebellum: 12.6 nTPM (vital, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101883,RHOXF1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 53.6765% (minimum 70%, Approved)",0.301235,0.195706,-0.163235,0,2,partial,12.6,1.7,1.6,"cerebellum: 12.6 nTPM (vital, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101883,RHOXF1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 53.6765% (minimum 75%, Baseline (adaptation disabled))",0.251235,0.195706,-0.213235,0,2,partial,12.6,1.7,1.6,"cerebellum: 12.6 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101883,RHOXF1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 0.4866% (minimum 99%, Missing); thymus: 50.0000% (minimum 95%, Missing)",-0.45,0.03,-0.985134,0,80,unavailable,40.9,0,0.2,"retina: 40.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101890,GUCY2F,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 0.4866% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.745134,0,80,unavailable,40.9,0,0.2,"retina: 40.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101890,GUCY2F,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 0.4866% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.745134,0,80,unavailable,40.9,0,0.2,"retina: 40.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101890,GUCY2F,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 0.4866% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.745134,0,80,unavailable,40.9,0,0.2,"retina: 40.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101890,GUCY2F,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 0.4866% (minimum 75%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 65%, Baseline (adaptation disabled))",-0.15,0.3,-0.745134,0,80,unavailable,40.9,0,0.2,"retina: 40.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101890,GUCY2F,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0498987,0.03,0.00828074,0,0,routine_complete,23.3,0.6,0.3,"smooth muscle: 23.3 nTPM (vital, limit 6); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101951,PAGE4,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349899,0.3,0.248281,0,0,routine_complete,23.3,0.6,0.3,"smooth muscle: 23.3 nTPM (vital, limit 6); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101951,PAGE4,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349899,0.3,0.248281,0,0,routine_complete,23.3,0.6,0.3,"smooth muscle: 23.3 nTPM (vital, limit 6); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101951,PAGE4,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349899,0.3,0.248281,0,0,routine_complete,23.3,0.6,0.3,"smooth muscle: 23.3 nTPM (vital, limit 6); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101951,PAGE4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349696,0.299393,0.22694,0,0,routine_complete,23.3,0.6,0.3,"smooth muscle: 23.3 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101951,PAGE4,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.7863% (minimum 99%, Missing); amygdala: 73.5000% (minimum 99%, Missing); basal ganglia: 66.5158% (minimum 99%, Missing); bone marrow: 96.0784% (minimum 99%, Missing); cerebellum: 81.2155% (minimum 99%, Missing); cerebral cortex: 62.0253% (minimum 99%, Missing); choroid plexus: 95.4545% (minimum 99%, Missing); heart muscle: 94.2308% (minimum 99%, Missing); hippocampal formation: 72.0588% (minimum 99%, Missing); hypothalamus: 55.8935% (minimum 99%, Missing); kidney: 91.3043% (minimum 99%, Missing); liver: 98.6577% (minimum 99%, Missing); lymph node: 96.7105% (minimum 97%, Missing); midbrain: 61.7647% (minimum 99%, Missing); pancreas: 98.6577% (minimum 99%, Missing); pituitary gland: 81.6667% (minimum 99%, Missing); retina: 62.2881% (minimum 99%, Missing); salivary gland: 93.6306% (minimum 97%, Missing); small intestine: 98.0000% (minimum 99%, Missing); spinal cord: 67.1233% (minimum 99%, Missing); spleen: 93.6306% (minimum 95%, Missing); thyroid gland: 93.0380% (minimum 95%, Missing)",-0.0196203,-0.0336943,-0.602137,0,80,unavailable,23.2,1,1.1,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101977,MCF2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.7863% (minimum 75%, Missing); amygdala: 73.5000% (minimum 75%, Missing); basal ganglia: 66.5158% (minimum 75%, Missing); cerebral cortex: 62.0253% (minimum 75%, Missing); hippocampal formation: 72.0588% (minimum 75%, Missing); hypothalamus: 55.8935% (minimum 75%, Missing); midbrain: 61.7647% (minimum 75%, Missing); retina: 62.2881% (minimum 75%, Missing); spinal cord: 67.1233% (minimum 75%, Missing)",0.28038,0.236306,-0.362137,0,80,unavailable,23.2,1,1.1,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101977,MCF2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.7863% (minimum 75%, Missing); amygdala: 73.5000% (minimum 75%, Missing); basal ganglia: 66.5158% (minimum 75%, Missing); cerebral cortex: 62.0253% (minimum 75%, Missing); hippocampal formation: 72.0588% (minimum 75%, Missing); hypothalamus: 55.8935% (minimum 75%, Missing); midbrain: 61.7647% (minimum 75%, Missing); retina: 62.2881% (minimum 75%, Missing); spinal cord: 67.1233% (minimum 75%, Missing)",0.28038,0.236306,-0.362137,0,80,unavailable,23.2,1,1.1,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101977,MCF2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.7863% (minimum 75%, Missing); amygdala: 73.5000% (minimum 75%, Missing); basal ganglia: 66.5158% (minimum 75%, Missing); cerebral cortex: 62.0253% (minimum 75%, Missing); hippocampal formation: 72.0588% (minimum 75%, Missing); hypothalamus: 55.8935% (minimum 75%, Missing); midbrain: 61.7647% (minimum 75%, Missing); retina: 62.2881% (minimum 75%, Missing); spinal cord: 67.1233% (minimum 75%, Missing)",0.28038,0.236306,-0.362137,0,80,unavailable,23.2,1,1.1,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101977,MCF2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.7863% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.5000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.5158% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.0253% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.0588% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.8935% (minimum 75%, Baseline (adaptation disabled)); midbrain: 61.7647% (minimum 75%, Baseline (adaptation disabled)); retina: 62.2881% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.1233% (minimum 75%, Baseline (adaptation disabled))",0.28038,0.236306,-0.362137,0,80,unavailable,23.2,1,1.1,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000101977,MCF2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102021,LUZP4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102021,LUZP4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102021,LUZP4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102021,LUZP4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102021,LUZP4,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.8189% (minimum 99%, Missing); bone marrow: 91.6058% (minimum 95%, Enhanced); choroid plexus: 98.4314% (minimum 99%, Missing); duodenum: 94.0075% (minimum 95%, Enhanced); heart muscle: 91.6058% (minimum 95%, Enhanced); hippocampal formation: 98.8189% (minimum 99%, Missing); kidney: 60.7748% (minimum 99%, Missing); liver: 59.7619% (minimum 95%, Enhanced); lung: 88.0702% (minimum 95%, Enhanced); midbrain: 98.8189% (minimum 99%, Missing); pancreas: 72.9651% (minimum 99%, Missing); pituitary gland: 98.4314% (minimum 99%, Missing); skin: 93.3086% (minimum 95%, Missing); smooth muscle: 91.9414% (minimum 95%, Enhanced); spinal cord: 98.8189% (minimum 99%, Missing); thymus: 86.5517% (minimum 95%, Missing); tongue: 95.0758% (minimum 97%, Missing)",-0.0844828,-0.0192424,-0.382252,0,6,partial,16.9,4,11.4,"liver: 16.9 nTPM (vital, limit 6); kidney: 16.2 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102048,ASB9,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 60.7748% (minimum 75%, Missing); liver: 59.7619% (minimum 60%, Enhanced); pancreas: 72.9651% (minimum 75%, Missing)",0.187671,0.250758,-0.142252,0,6,partial,16.9,4,11.4,"liver: 16.9 nTPM (vital, limit 6); kidney: 16.2 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102048,ASB9,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 60.7748% (minimum 75%, Missing); liver: 59.7619% (minimum 60%, Enhanced); pancreas: 72.9651% (minimum 75%, Missing)",0.187671,0.250758,-0.142252,0,6,partial,16.9,4,11.4,"liver: 16.9 nTPM (vital, limit 6); kidney: 16.2 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102048,ASB9,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 60.7748% (minimum 75%, Missing); liver: 59.7619% (minimum 60%, Enhanced); pancreas: 72.9651% (minimum 75%, Missing)",0.187671,0.250758,-0.142252,0,6,partial,16.9,4,11.4,"liver: 16.9 nTPM (vital, limit 6); kidney: 16.2 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102048,ASB9,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 60.7748% (minimum 75%, Baseline (adaptation disabled)); liver: 59.7619% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.9651% (minimum 75%, Baseline (adaptation disabled))",0.0376712,0.162543,-0.152381,0,6,partial,16.9,4,11.4,"liver: 16.9 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 9.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); salivary gland: 3.6 nTPM (protected, limit 3); lung: 3.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102048,ASB9,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0471098,0.0285528,0.005671,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000102055,PPP1R2C,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.34711,0.298553,0.245671,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000102055,PPP1R2C,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.34711,0.298553,0.245671,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000102055,PPP1R2C,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.34711,0.298553,0.245671,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000102055,PPP1R2C,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.34711,0.298553,0.245671,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000102055,PPP1R2C,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,248.2,0,0,"retina: 248.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102076,OPN1LW,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,248.2,0,0,"retina: 248.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102076,OPN1LW,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,248.2,0,0,"retina: 248.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102076,OPN1LW,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,248.2,0,0,"retina: 248.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102076,OPN1LW,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,248.2,0,0,"retina: 248.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102076,OPN1LW,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 74.1722% (minimum 95%, Enhanced); amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); bone marrow: 64.3678% (minimum 95%, Enhanced); cerebellum: 89.6000% (minimum 95%, Enhanced); cerebral cortex: 90.3226% (minimum 95%, Enhanced); choroid plexus: 93.3333% (minimum 99%, Missing); colon: 86.1538% (minimum 97%, Missing); duodenum: 91.0569% (minimum 95%, Enhanced); esophagus: 91.8033% (minimum 97%, Missing); heart muscle: 94.1176% (minimum 95%, Enhanced); hippocampal formation: 92.5620% (minimum 99%, Missing); hypothalamus: 93.3333% (minimum 99%, Missing); kidney: 94.1176% (minimum 99%, Missing); liver: 89.6000% (minimum 95%, Enhanced); lung: 95.7265% (minimum 99%, Missing); midbrain: 94.1176% (minimum 99%, Missing); pancreas: 89.6000% (minimum 95%, Enhanced); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 90.3226% (minimum 97%, Missing); retina: 76.7123% (minimum 99%, Missing); salivary gland: 56.8528% (minimum 80%, Enhanced); skeletal muscle: 89.6000% (minimum 95%, Enhanced); small intestine: 92.5620% (minimum 99%, Missing); smooth muscle: 82.3529% (minimum 95%, Enhanced); spinal cord: 92.5620% (minimum 99%, Missing); thymus: 77.2414% (minimum 95%, Missing); thyroid gland: 82.9630% (minimum 95%, Missing); tongue: 89.6000% (minimum 97%, Missing)",-0.177586,-0.231472,-0.306322,0,5,partial,6.2,8.5,3.3,"bone marrow: 6.2 nTPM (vital, limit 6); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102098,SCML2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.122414,0.0185279,0.0171233,0,5,partial,6.2,8.5,3.3,"bone marrow: 6.2 nTPM (vital, limit 6); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102098,SCML2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.122414,0.0185279,0.0171233,0,5,partial,6.2,8.5,3.3,"bone marrow: 6.2 nTPM (vital, limit 6); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102098,SCML2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.122414,0.0185279,0.0171233,0,5,partial,6.2,8.5,3.3,"bone marrow: 6.2 nTPM (vital, limit 6); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102098,SCML2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 74.1722% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 64.3678% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.8528% (minimum 70%, Baseline (adaptation disabled))",0.122414,-0.131472,-0.106322,0,5,partial,6.2,8.5,3.3,"salivary gland: 8.5 nTPM (protected, limit 3); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102098,SCML2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 96.8519% (minimum 97%, Supported); urinary bladder: 89.9909% (minimum 90%, Supported)",0.0489853,-9.14077e-05,-0.00148057,0,2,partial,6.4,21.9,0.6,"urinary bladder: 21.9 nTPM (protected, limit 6); kidney: 6.4 nTPM (vital, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102243,VGLL1,admission_only,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348985,0.299909,0.24294,0,2,partial,6.4,21.9,0.6,"urinary bladder: 21.9 nTPM (protected, limit 6); kidney: 6.4 nTPM (vital, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102243,VGLL1,selectivity_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348985,0.299909,0.24294,0,2,partial,6.4,21.9,0.6,"urinary bladder: 21.9 nTPM (protected, limit 6); kidney: 6.4 nTPM (vital, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102243,VGLL1,grid_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348985,0.299909,0.24294,0,2,partial,6.4,21.9,0.6,"urinary bladder: 21.9 nTPM (protected, limit 6); kidney: 6.4 nTPM (vital, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102243,VGLL1,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346962,0.199909,0.218519,0,2,partial,6.4,21.9,0.6,"urinary bladder: 21.9 nTPM (protected, limit 3); kidney: 6.4 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); lung: 2.1 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102243,VGLL1,current_fixed,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.8621% (minimum 90%, Approved); adrenal gland: 59.4595% (minimum 99%, Missing); amygdala: 68.7500% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 95.6522% (minimum 99%, Missing); cerebellum: 61.1111% (minimum 99%, Missing); cerebral cortex: 44.0000% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 70.9677% (minimum 97%, Missing); duodenum: 91.6667% (minimum 99%, Missing); esophagus: 73.3333% (minimum 97%, Missing); heart muscle: 57.8947% (minimum 99%, Missing); hippocampal formation: 68.7500% (minimum 99%, Missing); hypothalamus: 53.6585% (minimum 99%, Missing); kidney: 59.4595% (minimum 99%, Missing); liver: 95.6522% (minimum 99%, Missing); lung: 66.6667% (minimum 99%, Missing); lymph node: 88.0000% (minimum 95%, Approved); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 68.7500% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 68.7500% (minimum 99%, Missing); rectum: 81.4815% (minimum 97%, Missing); retina: 53.6585% (minimum 99%, Missing); salivary gland: 33.8462% (minimum 97%, Missing); skeletal muscle: 88.0000% (minimum 99%, Missing); skin: 75.8621% (minimum 95%, Missing); small intestine: 88.0000% (minimum 99%, Missing); smooth muscle: 61.1111% (minimum 98%, Approved); spinal cord: 62.8571% (minimum 99%, Missing); spleen: 75.8621% (minimum 90%, Approved); stomach: 84.6154% (minimum 97%, Missing); thymus: 73.3333% (minimum 95%, Missing); thyroid gland: 53.6585% (minimum 95%, Missing); tongue: 81.4815% (minimum 97%, Missing); urinary bladder: 78.5714% (minimum 97%, Missing)",-0.413415,-0.631538,-0.55,0,4,partial,2.8,4.3,1.9,"salivary gland: 4.3 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102383,ZDHHC15,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.4595% (minimum 75%, Missing); amygdala: 68.7500% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 61.1111% (minimum 75%, Missing); cerebral cortex: 44.0000% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); heart muscle: 57.8947% (minimum 75%, Missing); hippocampal formation: 68.7500% (minimum 75%, Missing); hypothalamus: 53.6585% (minimum 75%, Missing); kidney: 59.4595% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); retina: 53.6585% (minimum 75%, Missing); salivary gland: 33.8462% (minimum 70%, Missing); smooth muscle: 61.1111% (minimum 70%, Approved); spinal cord: 62.8571% (minimum 75%, Missing); thyroid gland: 53.6585% (minimum 65%, Missing)",-0.113415,-0.361538,-0.31,0,4,partial,2.8,4.3,1.9,"salivary gland: 4.3 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102383,ZDHHC15,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.4595% (minimum 75%, Missing); amygdala: 68.7500% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 61.1111% (minimum 75%, Missing); cerebral cortex: 44.0000% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); heart muscle: 57.8947% (minimum 75%, Missing); hippocampal formation: 68.7500% (minimum 75%, Missing); hypothalamus: 53.6585% (minimum 75%, Missing); kidney: 59.4595% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); retina: 53.6585% (minimum 75%, Missing); salivary gland: 33.8462% (minimum 70%, Missing); smooth muscle: 61.1111% (minimum 70%, Approved); spinal cord: 62.8571% (minimum 75%, Missing); thyroid gland: 53.6585% (minimum 65%, Missing)",-0.113415,-0.361538,-0.31,0,4,partial,2.8,4.3,1.9,"salivary gland: 4.3 nTPM (protected, limit 3); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102383,ZDHHC15,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.4595% (minimum 75%, Missing); amygdala: 68.7500% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 61.1111% (minimum 75%, Missing); cerebral cortex: 44.0000% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); heart muscle: 57.8947% (minimum 75%, Missing); hippocampal formation: 68.7500% (minimum 75%, Missing); hypothalamus: 53.6585% (minimum 75%, Missing); kidney: 59.4595% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); retina: 53.6585% (minimum 75%, Missing); salivary gland: 33.8462% (minimum 70%, Missing); smooth muscle: 61.1111% (minimum 70%, Approved); spinal cord: 62.8571% (minimum 75%, Missing); thyroid gland: 53.6585% (minimum 65%, Missing)",-0.113415,-0.361538,-0.31,0,4,partial,2.8,4.3,1.9,"salivary gland: 4.3 nTPM (protected, limit 3); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102383,ZDHHC15,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.4595% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.7500% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.1111% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 44.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 57.8947% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.7500% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.6585% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.4595% (minimum 75%, Baseline (adaptation disabled)); lung: 66.6667% (minimum 75%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.7500% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 68.7500% (minimum 75%, Baseline (adaptation disabled)); retina: 53.6585% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 33.8462% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 61.1111% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.8571% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 53.6585% (minimum 65%, Baseline (adaptation disabled))",-0.113415,-0.361538,-0.31,0,4,partial,2.8,4.3,1.9,"salivary gland: 4.3 nTPM (protected, limit 3); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102383,ZDHHC15,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Missing); adrenal gland: 86.3636% (minimum 99%, Missing); amygdala: 90.4762% (minimum 99%, Missing); basal ganglia: 90.4762% (minimum 99%, Missing); bone marrow: 25.6757% (minimum 99%, Missing); cerebellum: 95.0000% (minimum 99%, Missing); cerebral cortex: 70.3704% (minimum 99%, Missing); choroid plexus: 90.4762% (minimum 99%, Missing); colon: 48.7179% (minimum 97%, Missing); duodenum: 44.1860% (minimum 99%, Missing); esophagus: 48.7179% (minimum 97%, Missing); heart muscle: 82.6087% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 90.4762% (minimum 99%, Missing); kidney: 82.6087% (minimum 99%, Missing); liver: 73.0769% (minimum 99%, Missing); lung: 73.0769% (minimum 99%, Missing); lymph node: 30.6452% (minimum 97%, Missing); midbrain: 90.4762% (minimum 99%, Missing); pancreas: 86.3636% (minimum 99%, Missing); parathyroid gland: 90.4762% (minimum 97%, Missing); rectum: 41.3043% (minimum 97%, Missing); retina: 48.7179% (minimum 99%, Missing); salivary gland: 76.0000% (minimum 97%, Missing); skeletal muscle: 86.3636% (minimum 99%, Missing); skin: 37.2549% (minimum 95%, Missing); small intestine: 50.0000% (minimum 99%, Missing); smooth muscle: 51.3514% (minimum 99%, Missing); spinal cord: 82.6087% (minimum 99%, Missing); spleen: 55.8824% (minimum 95%, Missing); stomach: 61.2903% (minimum 97%, Missing); thymus: 26.7606% (minimum 95%, Missing); thyroid gland: 76.0000% (minimum 95%, Missing); tongue: 79.1667% (minimum 97%, Missing); urinary bladder: 65.5172% (minimum 97%, Missing)",-0.682394,-0.663548,-0.733243,0,80,unavailable,5.5,4.3,5.2,"bone marrow: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102384,CENPI,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 25.6757% (minimum 75%, Missing); cerebral cortex: 70.3704% (minimum 75%, Missing); colon: 48.7179% (minimum 70%, Missing); duodenum: 44.1860% (minimum 75%, Missing); esophagus: 48.7179% (minimum 70%, Missing); liver: 73.0769% (minimum 75%, Missing); lung: 73.0769% (minimum 75%, Missing); lymph node: 30.6452% (minimum 70%, Missing); rectum: 41.3043% (minimum 70%, Missing); retina: 48.7179% (minimum 75%, Missing); skin: 37.2549% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 51.3514% (minimum 75%, Missing); spleen: 55.8824% (minimum 65%, Missing); stomach: 61.2903% (minimum 70%, Missing); thymus: 26.7606% (minimum 65%, Missing); urinary bladder: 65.5172% (minimum 70%, Missing)",-0.382394,-0.393548,-0.493243,0,80,unavailable,5.5,4.3,5.2,"bone marrow: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102384,CENPI,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 25.6757% (minimum 75%, Missing); cerebral cortex: 70.3704% (minimum 75%, Missing); colon: 48.7179% (minimum 70%, Missing); duodenum: 44.1860% (minimum 75%, Missing); esophagus: 48.7179% (minimum 70%, Missing); liver: 73.0769% (minimum 75%, Missing); lung: 73.0769% (minimum 75%, Missing); lymph node: 30.6452% (minimum 70%, Missing); rectum: 41.3043% (minimum 70%, Missing); retina: 48.7179% (minimum 75%, Missing); skin: 37.2549% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 51.3514% (minimum 75%, Missing); spleen: 55.8824% (minimum 65%, Missing); stomach: 61.2903% (minimum 70%, Missing); thymus: 26.7606% (minimum 65%, Missing); urinary bladder: 65.5172% (minimum 70%, Missing)",-0.382394,-0.393548,-0.493243,0,80,unavailable,5.5,4.3,5.2,"bone marrow: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102384,CENPI,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 25.6757% (minimum 75%, Missing); cerebral cortex: 70.3704% (minimum 75%, Missing); colon: 48.7179% (minimum 70%, Missing); duodenum: 44.1860% (minimum 75%, Missing); esophagus: 48.7179% (minimum 70%, Missing); liver: 73.0769% (minimum 75%, Missing); lung: 73.0769% (minimum 75%, Missing); lymph node: 30.6452% (minimum 70%, Missing); rectum: 41.3043% (minimum 70%, Missing); retina: 48.7179% (minimum 75%, Missing); skin: 37.2549% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 51.3514% (minimum 75%, Missing); spleen: 55.8824% (minimum 65%, Missing); stomach: 61.2903% (minimum 70%, Missing); thymus: 26.7606% (minimum 65%, Missing); urinary bladder: 65.5172% (minimum 70%, Missing)",-0.382394,-0.393548,-0.493243,0,80,unavailable,5.5,4.3,5.2,"bone marrow: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102384,CENPI,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 25.6757% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.3704% (minimum 75%, Baseline (adaptation disabled)); colon: 48.7179% (minimum 70%, Baseline (adaptation disabled)); duodenum: 44.1860% (minimum 75%, Baseline (adaptation disabled)); esophagus: 48.7179% (minimum 70%, Baseline (adaptation disabled)); liver: 73.0769% (minimum 75%, Baseline (adaptation disabled)); lung: 73.0769% (minimum 75%, Baseline (adaptation disabled)); lymph node: 30.6452% (minimum 70%, Baseline (adaptation disabled)); rectum: 41.3043% (minimum 70%, Baseline (adaptation disabled)); retina: 48.7179% (minimum 75%, Baseline (adaptation disabled)); skin: 37.2549% (minimum 65%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 51.3514% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.8824% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.2903% (minimum 70%, Baseline (adaptation disabled)); thymus: 26.7606% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 65.5172% (minimum 70%, Baseline (adaptation disabled))",-0.382394,-0.393548,-0.493243,0,80,unavailable,5.5,4.3,5.2,"bone marrow: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102384,CENPI,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.8454% (minimum 99%, Missing); basal ganglia: 94.4615% (minimum 99%, Missing); cerebral cortex: 97.4603% (minimum 98%, Approved); choroid plexus: 88.7283% (minimum 99%, Missing); hippocampal formation: 96.5409% (minimum 99%, Missing); liver: 96.8454% (minimum 98%, Approved); parathyroid gland: 88.9855% (minimum 95%, Approved)",0.0467532,-0.0601449,-0.102717,0,4,partial,3.9,3.8,0.9,"choroid plexus: 3.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102387,TAF7L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346753,0.239855,0.137283,0,4,partial,3.9,3.8,0.9,"choroid plexus: 3.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102387,TAF7L,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346753,0.239855,0.137283,0,4,partial,3.9,3.8,0.9,"choroid plexus: 3.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102387,TAF7L,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346753,0.239855,0.137283,0,4,partial,3.9,3.8,0.9,"choroid plexus: 3.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102387,TAF7L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321519,0.189855,0.137283,0,4,partial,3.9,3.8,0.9,"choroid plexus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102387,TAF7L,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.2903% (minimum 95%, Uncertain); adrenal gland: 53.5211% (minimum 99%, Uncertain); amygdala: 64.9573% (minimum 99%, Missing); basal ganglia: 67.8571% (minimum 99%, Missing); bone marrow: 55.0725% (minimum 99%, Missing); cerebellum: 55.0725% (minimum 99%, Uncertain); cerebral cortex: 61.7886% (minimum 99%, Uncertain); choroid plexus: 62.8099% (minimum 99%, Missing); colon: 62.2951% (minimum 97%, Missing); duodenum: 71.6981% (minimum 99%, Uncertain); esophagus: 71.0280% (minimum 97%, Uncertain); heart muscle: 64.4068% (minimum 99%, Uncertain); hippocampal formation: 65.5172% (minimum 99%, Missing); hypothalamus: 62.8099% (minimum 99%, Missing); kidney: 45.2381% (minimum 99%, Uncertain); liver: 49.0323% (minimum 99%, Uncertain); lung: 69.0909% (minimum 99%, Uncertain); lymph node: 71.6981% (minimum 97%, Missing); midbrain: 65.5172% (minimum 99%, Missing); pancreas: 74.5098% (minimum 99%, Uncertain); parathyroid gland: 58.9147% (minimum 97%, Uncertain); pituitary gland: 70.3704% (minimum 99%, Missing); rectum: 71.0280% (minimum 97%, Uncertain); retina: 59.8425% (minimum 99%, Missing); salivary gland: 69.7248% (minimum 97%, Uncertain); skeletal muscle: 63.8655% (minimum 99%, Uncertain); skin: 77.5510% (minimum 95%, Uncertain); small intestine: 72.3810% (minimum 99%, Uncertain); smooth muscle: 67.8571% (minimum 99%, Uncertain); spinal cord: 68.4685% (minimum 99%, Missing); spleen: 65.5172% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Uncertain); thymus: 64.4068% (minimum 95%, Missing); thyroid gland: 45.5090% (minimum 95%, Uncertain); tongue: 60.3175% (minimum 97%, Missing); urinary bladder: 69.0909% (minimum 97%, Uncertain)",-0.49491,-0.380853,-0.537619,0,4,partial,9.2,5.3,9.1,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (manageable, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 2); retina: 5.1 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); cerebral cortex: 4.7 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 2); choroid plexus: 4.5 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); lymph node: 3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102543,CDADC1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.2903% (minimum 65%, Uncertain); adrenal gland: 53.5211% (minimum 75%, Uncertain); amygdala: 64.9573% (minimum 75%, Missing); basal ganglia: 67.8571% (minimum 75%, Missing); bone marrow: 55.0725% (minimum 75%, Missing); cerebellum: 55.0725% (minimum 75%, Uncertain); cerebral cortex: 61.7886% (minimum 75%, Uncertain); choroid plexus: 62.8099% (minimum 75%, Missing); colon: 62.2951% (minimum 70%, Missing); duodenum: 71.6981% (minimum 75%, Uncertain); heart muscle: 64.4068% (minimum 75%, Uncertain); hippocampal formation: 65.5172% (minimum 75%, Missing); hypothalamus: 62.8099% (minimum 75%, Missing); kidney: 45.2381% (minimum 75%, Uncertain); liver: 49.0323% (minimum 75%, Uncertain); lung: 69.0909% (minimum 75%, Uncertain); midbrain: 65.5172% (minimum 75%, Missing); pancreas: 74.5098% (minimum 75%, Uncertain); parathyroid gland: 58.9147% (minimum 70%, Uncertain); pituitary gland: 70.3704% (minimum 75%, Missing); retina: 59.8425% (minimum 75%, Missing); salivary gland: 69.7248% (minimum 70%, Uncertain); skeletal muscle: 63.8655% (minimum 75%, Uncertain); small intestine: 72.3810% (minimum 75%, Uncertain); smooth muscle: 67.8571% (minimum 75%, Uncertain); spinal cord: 68.4685% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Uncertain); thymus: 64.4068% (minimum 65%, Missing); thyroid gland: 45.5090% (minimum 65%, Uncertain); tongue: 60.3175% (minimum 70%, Missing); urinary bladder: 69.0909% (minimum 70%, Uncertain)",-0.19491,-0.110853,-0.297619,0,4,partial,9.2,5.3,9.1,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (manageable, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 2); retina: 5.1 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); cerebral cortex: 4.7 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 2); choroid plexus: 4.5 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); lymph node: 3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102543,CDADC1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.2903% (minimum 65%, Uncertain); adrenal gland: 53.5211% (minimum 75%, Uncertain); amygdala: 64.9573% (minimum 75%, Missing); basal ganglia: 67.8571% (minimum 75%, Missing); bone marrow: 55.0725% (minimum 75%, Missing); cerebellum: 55.0725% (minimum 75%, Uncertain); cerebral cortex: 61.7886% (minimum 75%, Uncertain); choroid plexus: 62.8099% (minimum 75%, Missing); colon: 62.2951% (minimum 70%, Missing); duodenum: 71.6981% (minimum 75%, Uncertain); heart muscle: 64.4068% (minimum 75%, Uncertain); hippocampal formation: 65.5172% (minimum 75%, Missing); hypothalamus: 62.8099% (minimum 75%, Missing); kidney: 45.2381% (minimum 75%, Uncertain); liver: 49.0323% (minimum 75%, Uncertain); lung: 69.0909% (minimum 75%, Uncertain); midbrain: 65.5172% (minimum 75%, Missing); pancreas: 74.5098% (minimum 75%, Uncertain); parathyroid gland: 58.9147% (minimum 70%, Uncertain); pituitary gland: 70.3704% (minimum 75%, Missing); retina: 59.8425% (minimum 75%, Missing); salivary gland: 69.7248% (minimum 70%, Uncertain); skeletal muscle: 63.8655% (minimum 75%, Uncertain); small intestine: 72.3810% (minimum 75%, Uncertain); smooth muscle: 67.8571% (minimum 75%, Uncertain); spinal cord: 68.4685% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Uncertain); thymus: 64.4068% (minimum 65%, Missing); thyroid gland: 45.5090% (minimum 65%, Uncertain); tongue: 60.3175% (minimum 70%, Missing); urinary bladder: 69.0909% (minimum 70%, Uncertain)",-0.19491,-0.110853,-0.297619,0,4,partial,9.2,5.3,9.1,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (manageable, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 3); retina: 5.1 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); cerebral cortex: 4.7 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); salivary gland: 3.3 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102543,CDADC1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.2903% (minimum 65%, Uncertain); adrenal gland: 53.5211% (minimum 75%, Uncertain); amygdala: 64.9573% (minimum 75%, Missing); basal ganglia: 67.8571% (minimum 75%, Missing); bone marrow: 55.0725% (minimum 75%, Missing); cerebellum: 55.0725% (minimum 75%, Uncertain); cerebral cortex: 61.7886% (minimum 75%, Uncertain); choroid plexus: 62.8099% (minimum 75%, Missing); colon: 62.2951% (minimum 70%, Missing); duodenum: 71.6981% (minimum 75%, Uncertain); heart muscle: 64.4068% (minimum 75%, Uncertain); hippocampal formation: 65.5172% (minimum 75%, Missing); hypothalamus: 62.8099% (minimum 75%, Missing); kidney: 45.2381% (minimum 75%, Uncertain); liver: 49.0323% (minimum 75%, Uncertain); lung: 69.0909% (minimum 75%, Uncertain); midbrain: 65.5172% (minimum 75%, Missing); pancreas: 74.5098% (minimum 75%, Uncertain); parathyroid gland: 58.9147% (minimum 70%, Uncertain); pituitary gland: 70.3704% (minimum 75%, Missing); retina: 59.8425% (minimum 75%, Missing); salivary gland: 69.7248% (minimum 70%, Uncertain); skeletal muscle: 63.8655% (minimum 75%, Uncertain); small intestine: 72.3810% (minimum 75%, Uncertain); smooth muscle: 67.8571% (minimum 75%, Uncertain); spinal cord: 68.4685% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Uncertain); thymus: 64.4068% (minimum 65%, Missing); thyroid gland: 45.5090% (minimum 65%, Uncertain); tongue: 60.3175% (minimum 70%, Missing); urinary bladder: 69.0909% (minimum 70%, Uncertain)",-0.19491,-0.110853,-0.297619,0,4,partial,9.2,5.3,9.1,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (manageable, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 3); retina: 5.1 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); cerebral cortex: 4.7 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); salivary gland: 3.3 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102543,CDADC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.2903% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 53.5211% (minimum 75%, Baseline (adaptation disabled)); amygdala: 64.9573% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 67.8571% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 55.0725% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.0725% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.7886% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 62.8099% (minimum 75%, Baseline (adaptation disabled)); colon: 62.2951% (minimum 70%, Baseline (adaptation disabled)); duodenum: 71.6981% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 64.4068% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.5172% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.8099% (minimum 75%, Baseline (adaptation disabled)); kidney: 45.2381% (minimum 75%, Baseline (adaptation disabled)); liver: 49.0323% (minimum 75%, Baseline (adaptation disabled)); lung: 69.0909% (minimum 75%, Baseline (adaptation disabled)); midbrain: 65.5172% (minimum 75%, Baseline (adaptation disabled)); pancreas: 74.5098% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.9147% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.3704% (minimum 75%, Baseline (adaptation disabled)); retina: 59.8425% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 69.7248% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 63.8655% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.3810% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.8571% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.4685% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 70%, Baseline (adaptation disabled)); thymus: 64.4068% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 45.5090% (minimum 65%, Baseline (adaptation disabled)); tongue: 60.3175% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 69.0909% (minimum 70%, Baseline (adaptation disabled))",-0.19491,-0.110853,-0.297619,0,4,partial,9.2,5.3,9.1,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (manageable, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 3); retina: 5.1 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); cerebral cortex: 4.7 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); salivary gland: 3.3 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102543,CDADC1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.7778% (minimum 95%, Missing); adrenal gland: 69.9552% (minimum 99%, Missing); amygdala: 78.3920% (minimum 99%, Missing); basal ganglia: 80.8290% (minimum 99%, Missing); bone marrow: 80.8290% (minimum 99%, Missing); cerebellum: 93.4132% (minimum 99%, Missing); cerebral cortex: 74.6411% (minimum 99%, Missing); choroid plexus: 69.3333% (minimum 99%, Missing); colon: 70.2703% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 80.4124% (minimum 97%, Missing); heart muscle: 65.0000% (minimum 99%, Missing); hippocampal formation: 74.2857% (minimum 99%, Missing); hypothalamus: 73.9336% (minimum 99%, Missing); kidney: 68.1223% (minimum 99%, Missing); liver: 65.8228% (minimum 99%, Missing); lung: 70.9091% (minimum 99%, Missing); lymph node: 84.3243% (minimum 97%, Missing); midbrain: 77.2277% (minimum 99%, Missing); pancreas: 60.2317% (minimum 99%, Missing); parathyroid gland: 67.8261% (minimum 97%, Missing); pituitary gland: 64.7303% (minimum 99%, Missing); rectum: 72.2222% (minimum 97%, Missing); retina: 67.8261% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 80.0000% (minimum 99%, Missing); skin: 77.2277% (minimum 95%, Missing); small intestine: 77.6119% (minimum 99%, Missing); smooth muscle: 61.9048% (minimum 99%, Missing); spinal cord: 73.2394% (minimum 99%, Missing); spleen: 80.8290% (minimum 95%, Missing); stomach: 66.9528% (minimum 97%, Missing); thymus: 92.8571% (minimum 95%, Missing); thyroid gland: 58.4270% (minimum 95%, Missing); tongue: 79.1878% (minimum 97%, Missing); urinary bladder: 66.1017% (minimum 97%, Missing)",-0.372222,-0.308983,-0.387683,0,80,unavailable,10.3,8,11.4,"adipose tissue: 11.4 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 2); salivary gland: 7.8 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); retina: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102595,UGGT2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.7778% (minimum 65%, Missing); adrenal gland: 69.9552% (minimum 75%, Missing); cerebral cortex: 74.6411% (minimum 75%, Missing); choroid plexus: 69.3333% (minimum 75%, Missing); heart muscle: 65.0000% (minimum 75%, Missing); hippocampal formation: 74.2857% (minimum 75%, Missing); hypothalamus: 73.9336% (minimum 75%, Missing); kidney: 68.1223% (minimum 75%, Missing); liver: 65.8228% (minimum 75%, Missing); lung: 70.9091% (minimum 75%, Missing); pancreas: 60.2317% (minimum 75%, Missing); parathyroid gland: 67.8261% (minimum 70%, Missing); pituitary gland: 64.7303% (minimum 75%, Missing); retina: 67.8261% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); smooth muscle: 61.9048% (minimum 75%, Missing); spinal cord: 73.2394% (minimum 75%, Missing); stomach: 66.9528% (minimum 70%, Missing); thyroid gland: 58.4270% (minimum 65%, Missing); urinary bladder: 66.1017% (minimum 70%, Missing)",-0.0722222,-0.0389831,-0.147683,0,80,unavailable,10.3,8,11.4,"adipose tissue: 11.4 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 2); salivary gland: 7.8 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); retina: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102595,UGGT2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.7778% (minimum 65%, Missing); adrenal gland: 69.9552% (minimum 75%, Missing); cerebral cortex: 74.6411% (minimum 75%, Missing); choroid plexus: 69.3333% (minimum 75%, Missing); heart muscle: 65.0000% (minimum 75%, Missing); hippocampal formation: 74.2857% (minimum 75%, Missing); hypothalamus: 73.9336% (minimum 75%, Missing); kidney: 68.1223% (minimum 75%, Missing); liver: 65.8228% (minimum 75%, Missing); lung: 70.9091% (minimum 75%, Missing); pancreas: 60.2317% (minimum 75%, Missing); parathyroid gland: 67.8261% (minimum 70%, Missing); pituitary gland: 64.7303% (minimum 75%, Missing); retina: 67.8261% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); smooth muscle: 61.9048% (minimum 75%, Missing); spinal cord: 73.2394% (minimum 75%, Missing); stomach: 66.9528% (minimum 70%, Missing); thyroid gland: 58.4270% (minimum 65%, Missing); urinary bladder: 66.1017% (minimum 70%, Missing)",-0.0722222,-0.0389831,-0.147683,0,80,unavailable,10.3,8,11.4,"adipose tissue: 11.4 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 3); salivary gland: 7.8 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); retina: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 3); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 3); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102595,UGGT2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.7778% (minimum 65%, Missing); adrenal gland: 69.9552% (minimum 75%, Missing); cerebral cortex: 74.6411% (minimum 75%, Missing); choroid plexus: 69.3333% (minimum 75%, Missing); heart muscle: 65.0000% (minimum 75%, Missing); hippocampal formation: 74.2857% (minimum 75%, Missing); hypothalamus: 73.9336% (minimum 75%, Missing); kidney: 68.1223% (minimum 75%, Missing); liver: 65.8228% (minimum 75%, Missing); lung: 70.9091% (minimum 75%, Missing); pancreas: 60.2317% (minimum 75%, Missing); parathyroid gland: 67.8261% (minimum 70%, Missing); pituitary gland: 64.7303% (minimum 75%, Missing); retina: 67.8261% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); smooth muscle: 61.9048% (minimum 75%, Missing); spinal cord: 73.2394% (minimum 75%, Missing); stomach: 66.9528% (minimum 70%, Missing); thyroid gland: 58.4270% (minimum 65%, Missing); urinary bladder: 66.1017% (minimum 70%, Missing)",-0.0722222,-0.0389831,-0.147683,0,80,unavailable,10.3,8,11.4,"adipose tissue: 11.4 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 3); salivary gland: 7.8 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); retina: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 3); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 3); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102595,UGGT2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.7778% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 69.9552% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.6411% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.3333% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 65.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.2857% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.9336% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.1223% (minimum 75%, Baseline (adaptation disabled)); liver: 65.8228% (minimum 75%, Baseline (adaptation disabled)); lung: 70.9091% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.2317% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 67.8261% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 64.7303% (minimum 75%, Baseline (adaptation disabled)); retina: 67.8261% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 61.9048% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.2394% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.9528% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 58.4270% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 66.1017% (minimum 70%, Baseline (adaptation disabled))",-0.0722222,-0.0389831,-0.147683,0,80,unavailable,10.3,8,11.4,"adipose tissue: 11.4 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 3); salivary gland: 7.8 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); retina: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 3); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 3); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102595,UGGT2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.3846% (minimum 95%, Missing); adrenal gland: 83.9506% (minimum 99%, Missing); amygdala: 81.9277% (minimum 99%, Missing); basal ganglia: 47.5524% (minimum 99%, Missing); bone marrow: 83.9506% (minimum 99%, Missing); cerebellum: 53.5433% (minimum 99%, Missing); cerebral cortex: 77.2727% (minimum 99%, Missing); choroid plexus: 94.4444% (minimum 99%, Missing); colon: 65.3846% (minimum 97%, Missing); duodenum: 81.9277% (minimum 99%, Missing); esophagus: 62.9630% (minimum 97%, Missing); heart muscle: 70.1031% (minimum 99%, Missing); hippocampal formation: 78.1609% (minimum 99%, Missing); hypothalamus: 79.0698% (minimum 99%, Missing); kidney: 68.0000% (minimum 99%, Missing); liver: 87.1795% (minimum 99%, Missing); lung: 47.5524% (minimum 99%, Missing); lymph node: 76.4045% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 87.1795% (minimum 99%, Missing); parathyroid gland: 91.8919% (minimum 97%, Missing); pituitary gland: 73.1183% (minimum 99%, Missing); rectum: 68.0000% (minimum 97%, Missing); retina: 73.1183% (minimum 99%, Missing); salivary gland: 70.1031% (minimum 97%, Missing); skeletal muscle: 81.9277% (minimum 99%, Missing); skin: 68.0000% (minimum 95%, Missing); small intestine: 72.3404% (minimum 99%, Missing); smooth muscle: 63.5514% (minimum 99%, Missing); spinal cord: 88.3117% (minimum 99%, Missing); spleen: 80.9524% (minimum 95%, Missing); stomach: 73.1183% (minimum 97%, Missing); thymus: 72.3404% (minimum 95%, Missing); thyroid gland: 73.9130% (minimum 95%, Missing); tongue: 76.4045% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",-0.296154,-0.398571,-0.514476,0,2,partial,7.5,5.1,3.6,"lung: 7.5 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); kidney: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); heart muscle: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); small intestine: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102780,DGKH,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 47.5524% (minimum 75%, Missing); cerebellum: 53.5433% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); esophagus: 62.9630% (minimum 70%, Missing); heart muscle: 70.1031% (minimum 75%, Missing); kidney: 68.0000% (minimum 75%, Missing); lung: 47.5524% (minimum 75%, Missing); pituitary gland: 73.1183% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 73.1183% (minimum 75%, Missing); small intestine: 72.3404% (minimum 75%, Missing); smooth muscle: 63.5514% (minimum 75%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",0.00384615,-0.128571,-0.274476,0,2,partial,7.5,5.1,3.6,"lung: 7.5 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); kidney: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); heart muscle: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); small intestine: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102780,DGKH,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 47.5524% (minimum 75%, Missing); cerebellum: 53.5433% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); esophagus: 62.9630% (minimum 70%, Missing); heart muscle: 70.1031% (minimum 75%, Missing); kidney: 68.0000% (minimum 75%, Missing); lung: 47.5524% (minimum 75%, Missing); pituitary gland: 73.1183% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 73.1183% (minimum 75%, Missing); small intestine: 72.3404% (minimum 75%, Missing); smooth muscle: 63.5514% (minimum 75%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",0.00384615,-0.128571,-0.274476,0,2,partial,7.5,5.1,3.6,"basal ganglia: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); kidney: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102780,DGKH,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 47.5524% (minimum 75%, Missing); cerebellum: 53.5433% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); esophagus: 62.9630% (minimum 70%, Missing); heart muscle: 70.1031% (minimum 75%, Missing); kidney: 68.0000% (minimum 75%, Missing); lung: 47.5524% (minimum 75%, Missing); pituitary gland: 73.1183% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 73.1183% (minimum 75%, Missing); small intestine: 72.3404% (minimum 75%, Missing); smooth muscle: 63.5514% (minimum 75%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",0.00384615,-0.128571,-0.274476,0,2,partial,7.5,5.1,3.6,"basal ganglia: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); kidney: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102780,DGKH,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 47.5524% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 53.5433% (minimum 75%, Baseline (adaptation disabled)); colon: 65.3846% (minimum 70%, Baseline (adaptation disabled)); esophagus: 62.9630% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.1031% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 47.5524% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 73.1183% (minimum 75%, Baseline (adaptation disabled)); rectum: 68.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 73.1183% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.3404% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.5514% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 70%, Baseline (adaptation disabled))",0.00384615,-0.128571,-0.274476,0,2,partial,7.5,5.1,3.6,"basal ganglia: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); kidney: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102780,DGKH,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.6294% (minimum 95%, Missing); adrenal gland: 84.5188% (minimum 99%, Missing); amygdala: 81.1245% (minimum 99%, Missing); basal ganglia: 82.4490% (minimum 99%, Missing); bone marrow: 75.9398% (minimum 99%, Missing); cerebellum: 77.6923% (minimum 99%, Missing); cerebral cortex: 67.7852% (minimum 99%, Missing); choroid plexus: 88.9868% (minimum 99%, Missing); colon: 70.6294% (minimum 97%, Missing); duodenum: 93.9535% (minimum 99%, Missing); esophagus: 78.2946% (minimum 97%, Missing); heart muscle: 53.8667% (minimum 99%, Missing); hippocampal formation: 79.5276% (minimum 99%, Missing); hypothalamus: 77.0992% (minimum 99%, Missing); kidney: 83.8174% (minimum 99%, Missing); liver: 84.1667% (minimum 99%, Missing); lung: 80.8000% (minimum 99%, Missing); lymph node: 75.9398% (minimum 97%, Missing); midbrain: 78.2946% (minimum 99%, Missing); pancreas: 91.8182% (minimum 99%, Missing); parathyroid gland: 90.5830% (minimum 97%, Missing); pituitary gland: 87.4459% (minimum 99%, Missing); rectum: 83.4711% (minimum 97%, Missing); retina: 72.6619% (minimum 99%, Missing); salivary gland: 90.5830% (minimum 97%, Missing); skeletal muscle: 80.4781% (minimum 99%, Missing); skin: 88.9868% (minimum 95%, Missing); small intestine: 88.2096% (minimum 99%, Missing); smooth muscle: 58.3815% (minimum 99%, Missing); spinal cord: 73.7226% (minimum 99%, Missing); spleen: 86.3248% (minimum 95%, Missing); stomach: 88.2096% (minimum 97%, Missing); thymus: 69.1781% (minimum 95%, Missing); thyroid gland: 87.4459% (minimum 95%, Missing); tongue: 76.2264% (minimum 97%, Missing); urinary bladder: 80.8000% (minimum 97%, Missing)",-0.258219,-0.263706,-0.451333,0,80,unavailable,17.3,8.4,9,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); adipose tissue: 8.4 nTPM (manageable, limit 5); colon: 8.4 nTPM (protected, limit 2); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); bone marrow: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 2); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102781,KATNAL1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 67.7852% (minimum 75%, Missing); heart muscle: 53.8667% (minimum 75%, Missing); retina: 72.6619% (minimum 75%, Missing); smooth muscle: 58.3815% (minimum 75%, Missing); spinal cord: 73.7226% (minimum 75%, Missing)",0.0417808,0.00629371,-0.211333,0,80,unavailable,17.3,8.4,9,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); adipose tissue: 8.4 nTPM (manageable, limit 5); colon: 8.4 nTPM (protected, limit 2); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); bone marrow: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 2); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102781,KATNAL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 67.7852% (minimum 75%, Missing); heart muscle: 53.8667% (minimum 75%, Missing); retina: 72.6619% (minimum 75%, Missing); smooth muscle: 58.3815% (minimum 75%, Missing); spinal cord: 73.7226% (minimum 75%, Missing)",0.0417808,0.00629371,-0.211333,0,80,unavailable,17.3,8.4,9,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); adipose tissue: 8.4 nTPM (manageable, limit 5); colon: 8.4 nTPM (protected, limit 3); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); bone marrow: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 3); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); lung: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102781,KATNAL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 67.7852% (minimum 75%, Missing); heart muscle: 53.8667% (minimum 75%, Missing); retina: 72.6619% (minimum 75%, Missing); smooth muscle: 58.3815% (minimum 75%, Missing); spinal cord: 73.7226% (minimum 75%, Missing)",0.0417808,0.00629371,-0.211333,0,80,unavailable,17.3,8.4,9,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); adipose tissue: 8.4 nTPM (manageable, limit 5); colon: 8.4 nTPM (protected, limit 3); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); bone marrow: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 3); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); lung: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102781,KATNAL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 67.7852% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 53.8667% (minimum 75%, Baseline (adaptation disabled)); retina: 72.6619% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.3815% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.7226% (minimum 75%, Baseline (adaptation disabled))",0.0417808,0.00629371,-0.211333,0,80,unavailable,17.3,8.4,9,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); adipose tissue: 8.4 nTPM (manageable, limit 5); colon: 8.4 nTPM (protected, limit 3); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); bone marrow: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 3); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); lung: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102781,KATNAL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.1132% (minimum 95%, Missing); adrenal gland: 96.8750% (minimum 99%, Missing); amygdala: 95.3846% (minimum 99%, Missing); basal ganglia: 88.8252% (minimum 99%, Missing); cerebellum: 6.5845% (minimum 99%, Missing); cerebral cortex: 84.9315% (minimum 99%, Missing); choroid plexus: 97.7918% (minimum 99%, Missing); duodenum: 97.1787% (minimum 99%, Missing); esophagus: 96.8750% (minimum 97%, Missing); heart muscle: 87.5706% (minimum 99%, Missing); hippocampal formation: 95.9752% (minimum 99%, Missing); hypothalamus: 45.3216% (minimum 99%, Missing); liver: 96.8750% (minimum 99%, Missing); midbrain: 63.6550% (minimum 99%, Missing); pancreas: 91.9881% (minimum 99%, Missing); pituitary gland: 88.3191% (minimum 99%, Missing); retina: 90.1163% (minimum 99%, Missing); skeletal muscle: 97.1787% (minimum 99%, Missing); small intestine: 95.9752% (minimum 99%, Missing); smooth muscle: 94.8012% (minimum 99%, Missing); spinal cord: 76.1671% (minimum 99%, Missing); thyroid gland: 93.3735% (minimum 95%, Missing); tongue: 94.8012% (minimum 97%, Missing); urinary bladder: 95.6790% (minimum 97%, Missing)",-0.218868,-0.0219878,-0.924155,0,80,unavailable,439.8,1.7,11.4,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102924,CBLN1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 6.5845% (minimum 75%, Missing); hypothalamus: 45.3216% (minimum 75%, Missing); midbrain: 63.6550% (minimum 75%, Missing)",0.0811321,0.248012,-0.684155,0,80,unavailable,439.8,1.7,11.4,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102924,CBLN1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 6.5845% (minimum 75%, Missing); hypothalamus: 45.3216% (minimum 75%, Missing); midbrain: 63.6550% (minimum 75%, Missing)",0.0811321,0.248012,-0.684155,0,80,unavailable,439.8,1.7,11.4,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102924,CBLN1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 6.5845% (minimum 75%, Missing); hypothalamus: 45.3216% (minimum 75%, Missing); midbrain: 63.6550% (minimum 75%, Missing)",0.0811321,0.248012,-0.684155,0,80,unavailable,439.8,1.7,11.4,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102924,CBLN1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 6.5845% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 45.3216% (minimum 75%, Baseline (adaptation disabled)); midbrain: 63.6550% (minimum 75%, Baseline (adaptation disabled))",0.0811321,0.248012,-0.684155,0,80,unavailable,439.8,1.7,11.4,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102924,CBLN1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.3333% (minimum 95%, Uncertain); adrenal gland: 95.0000% (minimum 99%, Missing); amygdala: 95.0000% (minimum 99%, Missing); cerebellum: 95.0000% (minimum 99%, Missing); cerebral cortex: 95.0000% (minimum 99%, Missing); choroid plexus: 95.0000% (minimum 99%, Missing); colon: 57.5758% (minimum 97%, Missing); duodenum: 95.0000% (minimum 99%, Missing); esophagus: 38.7755% (minimum 97%, Uncertain); heart muscle: 59.3750% (minimum 99%, Missing); hippocampal formation: 95.0000% (minimum 99%, Missing); kidney: 76.0000% (minimum 99%, Missing); liver: 86.3636% (minimum 99%, Missing); lung: 30.1587% (minimum 99%, Missing); lymph node: 18.8119% (minimum 97%, Missing); pancreas: 82.6087% (minimum 99%, Missing); parathyroid gland: 95.0000% (minimum 97%, Missing); rectum: 42.2222% (minimum 97%, Missing); salivary gland: 43.1818% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); skin: 44.1860% (minimum 95%, Missing); small intestine: 34.5455% (minimum 99%, Missing); smooth muscle: 43.1818% (minimum 99%, Missing); spinal cord: 95.0000% (minimum 99%, Missing); spleen: 70.3704% (minimum 95%, Uncertain); stomach: 73.0769% (minimum 97%, Missing); thymus: 8.4821% (minimum 95%, Missing); thyroid gland: 70.3704% (minimum 95%, Missing); tongue: 90.4762% (minimum 97%, Missing); urinary bladder: 36.5385% (minimum 97%, Missing)",-0.865179,-0.781881,-0.688413,0,3,partial,4.4,8.2,20.5,"thymus: 20.5 nTPM (manageable, limit 5); lymph node: 8.2 nTPM (protected, limit 2); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102970,CCL17,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.3333% (minimum 65%, Uncertain); colon: 57.5758% (minimum 70%, Missing); esophagus: 38.7755% (minimum 70%, Uncertain); heart muscle: 59.3750% (minimum 75%, Missing); lung: 30.1587% (minimum 75%, Missing); lymph node: 18.8119% (minimum 70%, Missing); rectum: 42.2222% (minimum 70%, Missing); salivary gland: 43.1818% (minimum 70%, Missing); skin: 44.1860% (minimum 65%, Missing); small intestine: 34.5455% (minimum 75%, Missing); smooth muscle: 43.1818% (minimum 75%, Missing); thymus: 8.4821% (minimum 65%, Missing); urinary bladder: 36.5385% (minimum 70%, Missing)",-0.565179,-0.511881,-0.448413,0,3,partial,4.4,8.2,20.5,"thymus: 20.5 nTPM (manageable, limit 5); lymph node: 8.2 nTPM (protected, limit 2); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102970,CCL17,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.3333% (minimum 65%, Uncertain); colon: 57.5758% (minimum 70%, Missing); esophagus: 38.7755% (minimum 70%, Uncertain); heart muscle: 59.3750% (minimum 75%, Missing); lung: 30.1587% (minimum 75%, Missing); lymph node: 18.8119% (minimum 70%, Missing); rectum: 42.2222% (minimum 70%, Missing); salivary gland: 43.1818% (minimum 70%, Missing); skin: 44.1860% (minimum 65%, Missing); small intestine: 34.5455% (minimum 75%, Missing); smooth muscle: 43.1818% (minimum 75%, Missing); thymus: 8.4821% (minimum 65%, Missing); urinary bladder: 36.5385% (minimum 70%, Missing)",-0.565179,-0.511881,-0.448413,0,3,partial,4.4,8.2,20.5,"thymus: 20.5 nTPM (manageable, limit 5); lymph node: 8.2 nTPM (protected, limit 3); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102970,CCL17,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.3333% (minimum 65%, Uncertain); colon: 57.5758% (minimum 70%, Missing); esophagus: 38.7755% (minimum 70%, Uncertain); heart muscle: 59.3750% (minimum 75%, Missing); lung: 30.1587% (minimum 75%, Missing); lymph node: 18.8119% (minimum 70%, Missing); rectum: 42.2222% (minimum 70%, Missing); salivary gland: 43.1818% (minimum 70%, Missing); skin: 44.1860% (minimum 65%, Missing); small intestine: 34.5455% (minimum 75%, Missing); smooth muscle: 43.1818% (minimum 75%, Missing); thymus: 8.4821% (minimum 65%, Missing); urinary bladder: 36.5385% (minimum 70%, Missing)",-0.565179,-0.511881,-0.448413,0,3,partial,4.4,8.2,20.5,"thymus: 20.5 nTPM (manageable, limit 5); lymph node: 8.2 nTPM (protected, limit 3); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102970,CCL17,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.3333% (minimum 65%, Baseline (adaptation disabled)); colon: 57.5758% (minimum 70%, Baseline (adaptation disabled)); esophagus: 38.7755% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.3750% (minimum 75%, Baseline (adaptation disabled)); lung: 30.1587% (minimum 75%, Baseline (adaptation disabled)); lymph node: 18.8119% (minimum 70%, Baseline (adaptation disabled)); rectum: 42.2222% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 43.1818% (minimum 70%, Baseline (adaptation disabled)); skin: 44.1860% (minimum 65%, Baseline (adaptation disabled)); small intestine: 34.5455% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 43.1818% (minimum 75%, Baseline (adaptation disabled)); thymus: 8.4821% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 36.5385% (minimum 70%, Baseline (adaptation disabled))",-0.565179,-0.511881,-0.448413,0,3,partial,4.4,8.2,20.5,"thymus: 20.5 nTPM (manageable, limit 5); lymph node: 8.2 nTPM (protected, limit 3); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000102970,CCL17,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.6380% (minimum 99%, Missing); amygdala: 84.3575% (minimum 99%, Missing); basal ganglia: 81.8428% (minimum 99%, Missing); cerebellum: 93.4985% (minimum 99%, Missing); cerebral cortex: 82.5137% (minimum 99%, Missing); choroid plexus: 76.4557% (minimum 99%, Missing); colon: 96.4856% (minimum 97%, Missing); duodenum: 98.6928% (minimum 99%, Missing); esophagus: 95.5696% (minimum 97%, Missing); heart muscle: 90.4192% (minimum 99%, Missing); hippocampal formation: 82.9670% (minimum 99%, Missing); hypothalamus: 84.1226% (minimum 99%, Missing); kidney: 94.6708% (minimum 99%, Missing); liver: 96.7949% (minimum 99%, Missing); lung: 89.6142% (minimum 99%, Missing); midbrain: 87.2832% (minimum 99%, Missing); pancreas: 95.8730% (minimum 99%, Missing); parathyroid gland: 82.0652% (minimum 97%, Missing); pituitary gland: 90.6907% (minimum 99%, Missing); rectum: 94.9686% (minimum 97%, Missing); retina: 76.8448% (minimum 99%, Missing); salivary gland: 96.7949% (minimum 97%, Missing); skeletal muscle: 92.0732% (minimum 99%, Missing); skin: 92.6380% (minimum 95%, Missing); small intestine: 98.6928% (minimum 99%, Missing); smooth muscle: 95.5696% (minimum 99%, Missing); spinal cord: 89.8810% (minimum 99%, Missing); stomach: 95.5696% (minimum 97%, Missing); thyroid gland: 93.2099% (minimum 95%, Missing); tongue: 92.9231% (minimum 97%, Missing); urinary bladder: 95.8730% (minimum 97%, Missing)",-0.0236196,-0.149348,-0.225443,0,80,unavailable,9.3,6.6,2.4,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103021,CFAP263,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.27638,0.120652,0.014557,0,80,unavailable,9.3,6.6,2.4,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103021,CFAP263,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.27638,0.120652,0.014557,0,80,unavailable,9.3,6.6,2.4,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103021,CFAP263,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.27638,0.120652,0.014557,0,80,unavailable,9.3,6.6,2.4,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103021,CFAP263,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.27638,0.120652,0.014557,0,80,unavailable,9.3,6.6,2.4,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103021,CFAP263,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.00751861,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103023,PRSS54,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247519,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103023,PRSS54,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247519,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103023,PRSS54,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247519,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103023,PRSS54,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247519,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103023,PRSS54,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6872% (minimum 95%, Missing); adrenal gland: 62.6374% (minimum 99%, Missing); amygdala: 65.1429% (minimum 99%, Missing); basal ganglia: 63.3333% (minimum 99%, Missing); bone marrow: 74.0260% (minimum 99%, Missing); cerebellum: 56.4356% (minimum 99%, Missing); cerebral cortex: 60.9626% (minimum 99%, Missing); choroid plexus: 65.5172% (minimum 99%, Missing); colon: 53.0233% (minimum 97%, Missing); duodenum: 65.5172% (minimum 98%, Approved); esophagus: 65.8960% (minimum 97%, Missing); heart muscle: 54.0284% (minimum 99%, Missing); hippocampal formation: 63.3333% (minimum 99%, Missing); hypothalamus: 62.6374% (minimum 99%, Missing); kidney: 64.0449% (minimum 99%, Missing); liver: 63.6872% (minimum 99%, Missing); lung: 68.6747% (minimum 99%, Missing); lymph node: 58.7629% (minimum 95%, Approved); midbrain: 63.3333% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 45.6000% (minimum 97%, Missing); pituitary gland: 55.8824% (minimum 99%, Missing); rectum: 62.2951% (minimum 97%, Missing); retina: 54.2857% (minimum 99%, Missing); salivary gland: 59.6859% (minimum 97%, Missing); skeletal muscle: 54.5455% (minimum 99%, Missing); skin: 61.2903% (minimum 95%, Missing); small intestine: 64.4068% (minimum 98%, Approved); smooth muscle: 53.2710% (minimum 99%, Missing); spinal cord: 58.4615% (minimum 99%, Missing); spleen: 61.6216% (minimum 90%, Approved); stomach: 63.3333% (minimum 97%, Missing); thymus: 55.0725% (minimum 95%, Missing); thyroid gland: 60.9626% (minimum 95%, Missing); tongue: 52.7778% (minimum 97%, Missing); urinary bladder: 56.7164% (minimum 97%, Missing)",-0.399275,-0.514,-0.45729,0,2,partial,10,13.6,9.3,"parathyroid gland: 13.6 nTPM (protected, limit 2); tongue: 10.2 nTPM (protected, limit 2); colon: 10.1 nTPM (protected, limit 2); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 2); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 4); salivary gland: 7.7 nTPM (protected, limit 2); thyroid gland: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); rectum: 6.9 nTPM (protected, limit 2); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); basal ganglia: 6.6 nTPM (vital, limit 1); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 2); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 2); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 2); pancreas: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103343,ZNF174,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6872% (minimum 65%, Missing); adrenal gland: 62.6374% (minimum 75%, Missing); amygdala: 65.1429% (minimum 75%, Missing); basal ganglia: 63.3333% (minimum 75%, Missing); bone marrow: 74.0260% (minimum 75%, Missing); cerebellum: 56.4356% (minimum 75%, Missing); cerebral cortex: 60.9626% (minimum 75%, Missing); choroid plexus: 65.5172% (minimum 75%, Missing); colon: 53.0233% (minimum 70%, Missing); duodenum: 65.5172% (minimum 70%, Approved); esophagus: 65.8960% (minimum 70%, Missing); heart muscle: 54.0284% (minimum 75%, Missing); hippocampal formation: 63.3333% (minimum 75%, Missing); hypothalamus: 62.6374% (minimum 75%, Missing); kidney: 64.0449% (minimum 75%, Missing); liver: 63.6872% (minimum 75%, Missing); lung: 68.6747% (minimum 75%, Missing); lymph node: 58.7629% (minimum 65%, Approved); midbrain: 63.3333% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 45.6000% (minimum 70%, Missing); pituitary gland: 55.8824% (minimum 75%, Missing); rectum: 62.2951% (minimum 70%, Missing); retina: 54.2857% (minimum 75%, Missing); salivary gland: 59.6859% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 61.2903% (minimum 65%, Missing); small intestine: 64.4068% (minimum 70%, Approved); smooth muscle: 53.2710% (minimum 75%, Missing); spinal cord: 58.4615% (minimum 75%, Missing); stomach: 63.3333% (minimum 70%, Missing); thymus: 55.0725% (minimum 65%, Missing); thyroid gland: 60.9626% (minimum 65%, Missing); tongue: 52.7778% (minimum 70%, Missing); urinary bladder: 56.7164% (minimum 70%, Missing)",-0.0992754,-0.244,-0.21729,0,2,partial,10,13.6,9.3,"parathyroid gland: 13.6 nTPM (protected, limit 2); tongue: 10.2 nTPM (protected, limit 2); colon: 10.1 nTPM (protected, limit 2); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 2); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 4); salivary gland: 7.7 nTPM (protected, limit 2); thyroid gland: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); rectum: 6.9 nTPM (protected, limit 2); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); basal ganglia: 6.6 nTPM (vital, limit 1); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 2); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 2); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 2); pancreas: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103343,ZNF174,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6872% (minimum 65%, Missing); adrenal gland: 62.6374% (minimum 75%, Missing); amygdala: 65.1429% (minimum 75%, Missing); basal ganglia: 63.3333% (minimum 75%, Missing); bone marrow: 74.0260% (minimum 75%, Missing); cerebellum: 56.4356% (minimum 75%, Missing); cerebral cortex: 60.9626% (minimum 75%, Missing); choroid plexus: 65.5172% (minimum 75%, Missing); colon: 53.0233% (minimum 70%, Missing); duodenum: 65.5172% (minimum 70%, Approved); esophagus: 65.8960% (minimum 70%, Missing); heart muscle: 54.0284% (minimum 75%, Missing); hippocampal formation: 63.3333% (minimum 75%, Missing); hypothalamus: 62.6374% (minimum 75%, Missing); kidney: 64.0449% (minimum 75%, Missing); liver: 63.6872% (minimum 75%, Missing); lung: 68.6747% (minimum 75%, Missing); lymph node: 58.7629% (minimum 65%, Approved); midbrain: 63.3333% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 45.6000% (minimum 70%, Missing); pituitary gland: 55.8824% (minimum 75%, Missing); rectum: 62.2951% (minimum 70%, Missing); retina: 54.2857% (minimum 75%, Missing); salivary gland: 59.6859% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 61.2903% (minimum 65%, Missing); small intestine: 64.4068% (minimum 70%, Approved); smooth muscle: 53.2710% (minimum 75%, Missing); spinal cord: 58.4615% (minimum 75%, Missing); stomach: 63.3333% (minimum 70%, Missing); thymus: 55.0725% (minimum 65%, Missing); thyroid gland: 60.9626% (minimum 65%, Missing); tongue: 52.7778% (minimum 70%, Missing); urinary bladder: 56.7164% (minimum 70%, Missing)",-0.0992754,-0.244,-0.21729,0,2,partial,10,13.6,9.3,"parathyroid gland: 13.6 nTPM (protected, limit 3); tongue: 10.2 nTPM (protected, limit 3); colon: 10.1 nTPM (protected, limit 3); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 3); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 4); salivary gland: 7.7 nTPM (protected, limit 3); thyroid gland: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); rectum: 6.9 nTPM (protected, limit 3); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); basal ganglia: 6.6 nTPM (vital, limit 1); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 2); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 2); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 3); pancreas: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103343,ZNF174,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6872% (minimum 65%, Missing); adrenal gland: 62.6374% (minimum 75%, Missing); amygdala: 65.1429% (minimum 75%, Missing); basal ganglia: 63.3333% (minimum 75%, Missing); bone marrow: 74.0260% (minimum 75%, Missing); cerebellum: 56.4356% (minimum 75%, Missing); cerebral cortex: 60.9626% (minimum 75%, Missing); choroid plexus: 65.5172% (minimum 75%, Missing); colon: 53.0233% (minimum 70%, Missing); duodenum: 65.5172% (minimum 70%, Approved); esophagus: 65.8960% (minimum 70%, Missing); heart muscle: 54.0284% (minimum 75%, Missing); hippocampal formation: 63.3333% (minimum 75%, Missing); hypothalamus: 62.6374% (minimum 75%, Missing); kidney: 64.0449% (minimum 75%, Missing); liver: 63.6872% (minimum 75%, Missing); lung: 68.6747% (minimum 75%, Missing); lymph node: 58.7629% (minimum 65%, Approved); midbrain: 63.3333% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 45.6000% (minimum 70%, Missing); pituitary gland: 55.8824% (minimum 75%, Missing); rectum: 62.2951% (minimum 70%, Missing); retina: 54.2857% (minimum 75%, Missing); salivary gland: 59.6859% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 61.2903% (minimum 65%, Missing); small intestine: 64.4068% (minimum 70%, Approved); smooth muscle: 53.2710% (minimum 75%, Missing); spinal cord: 58.4615% (minimum 75%, Missing); stomach: 63.3333% (minimum 70%, Missing); thymus: 55.0725% (minimum 65%, Missing); thyroid gland: 60.9626% (minimum 65%, Missing); tongue: 52.7778% (minimum 70%, Missing); urinary bladder: 56.7164% (minimum 70%, Missing)",-0.0992754,-0.244,-0.21729,0,2,partial,10,13.6,9.3,"parathyroid gland: 13.6 nTPM (protected, limit 3); tongue: 10.2 nTPM (protected, limit 3); colon: 10.1 nTPM (protected, limit 3); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 3); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 4); salivary gland: 7.7 nTPM (protected, limit 3); thyroid gland: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); rectum: 6.9 nTPM (protected, limit 3); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); basal ganglia: 6.6 nTPM (vital, limit 1); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 2); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 2); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 3); pancreas: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103343,ZNF174,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6872% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.6374% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.1429% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 63.3333% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 74.0260% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.4356% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.9626% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 65.5172% (minimum 75%, Baseline (adaptation disabled)); colon: 53.0233% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.5172% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.8960% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 54.0284% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.6374% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.0449% (minimum 75%, Baseline (adaptation disabled)); liver: 63.6872% (minimum 75%, Baseline (adaptation disabled)); lung: 68.6747% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.7629% (minimum 70%, Baseline (adaptation disabled)); midbrain: 63.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 45.6000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.8824% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.2951% (minimum 70%, Baseline (adaptation disabled)); retina: 54.2857% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.6859% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 54.5455% (minimum 75%, Baseline (adaptation disabled)); skin: 61.2903% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.4068% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.2710% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 58.4615% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.6216% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.3333% (minimum 70%, Baseline (adaptation disabled)); thymus: 55.0725% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 60.9626% (minimum 65%, Baseline (adaptation disabled)); tongue: 52.7778% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.7164% (minimum 70%, Baseline (adaptation disabled))",-0.0992754,-0.244,-0.21729,0,2,partial,10,13.6,9.3,"parathyroid gland: 13.6 nTPM (protected, limit 3); tongue: 10.2 nTPM (protected, limit 3); colon: 10.1 nTPM (protected, limit 3); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 3); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 3); salivary gland: 7.7 nTPM (protected, limit 3); cerebral cortex: 7.3 nTPM (vital, limit 1); thyroid gland: 7.3 nTPM (manageable, limit 5); skin: 7.2 nTPM (manageable, limit 5); spleen: 7.1 nTPM (manageable, limit 5); rectum: 6.9 nTPM (protected, limit 3); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); midbrain: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 3); pancreas: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103343,ZNF174,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 39.5210% (minimum 95%, Enhanced); amygdala: 98.5075% (minimum 99%, Missing); skin: 59.4595% (minimum 60%, Enhanced)",-0.00540541,0.03,-0.55479,0,4,partial,10.1,1.1,4.5,"adrenal gland: 10.1 nTPM (vital, limit 6)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103546,SLC6A2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 39.5210% (minimum 60%, Enhanced)",0.0945946,0.3,-0.20479,0,4,partial,10.1,1.1,4.5,"adrenal gland: 10.1 nTPM (vital, limit 6)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103546,SLC6A2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 39.5210% (minimum 60%, Enhanced)",0.0945946,0.3,-0.20479,0,4,partial,10.1,1.1,4.5,"adrenal gland: 10.1 nTPM (vital, limit 6)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103546,SLC6A2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 39.5210% (minimum 60%, Enhanced)",0.0945946,0.3,-0.20479,0,4,partial,10.1,1.1,4.5,"adrenal gland: 10.1 nTPM (vital, limit 6)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103546,SLC6A2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 39.5210% (minimum 75%, Baseline (adaptation disabled)); skin: 59.4595% (minimum 65%, Baseline (adaptation disabled))",-0.0554054,0.157143,-0.35479,0,4,partial,10.1,1.1,4.5,"adrenal gland: 10.1 nTPM (vital, limit 1)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103546,SLC6A2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.0569% (minimum 99%, Missing); amygdala: 95.7265% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); cerebellum: 98.2456% (minimum 99%, Missing); cerebral cortex: 93.3333% (minimum 99%, Missing); choroid plexus: 87.5000% (minimum 99%, Missing); colon: 96.5517% (minimum 97%, Missing); esophagus: 95.7265% (minimum 97%, Missing); heart muscle: 92.5620% (minimum 99%, Missing); hippocampal formation: 94.1176% (minimum 99%, Missing); hypothalamus: 91.0569% (minimum 99%, Missing); kidney: 84.2105% (minimum 99%, Missing); liver: 92.5620% (minimum 99%, Missing); lung: 92.5620% (minimum 99%, Missing); midbrain: 95.7265% (minimum 99%, Missing); pancreas: 94.1176% (minimum 99%, Missing); parathyroid gland: 75.6757% (minimum 97%, Missing); pituitary gland: 84.8485% (minimum 99%, Missing); rectum: 94.1176% (minimum 97%, Missing); retina: 70.0000% (minimum 99%, Missing); salivary gland: 94.9153% (minimum 97%, Missing); skeletal muscle: 95.7265% (minimum 99%, Missing); skin: 94.9153% (minimum 95%, Missing); smooth muscle: 98.2456% (minimum 99%, Missing); spinal cord: 95.7265% (minimum 99%, Missing); stomach: 91.0569% (minimum 97%, Missing); thymus: 91.8033% (minimum 95%, Missing); thyroid gland: 74.1722% (minimum 95%, Missing); urinary bladder: 94.1176% (minimum 97%, Missing)",-0.208278,-0.213243,-0.29,0,80,unavailable,4.8,3.6,3.9,"retina: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103599,IQCH,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.0000% (minimum 75%, Missing)",0.0917219,0.0567568,-0.05,0,80,unavailable,4.8,3.6,3.9,"retina: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103599,IQCH,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.0000% (minimum 75%, Missing)",0.0917219,0.0567568,-0.05,0,80,unavailable,4.8,3.6,3.9,"retina: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103599,IQCH,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.0000% (minimum 75%, Missing)",0.0917219,0.0567568,-0.05,0,80,unavailable,4.8,3.6,3.9,"retina: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103599,IQCH,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.0000% (minimum 75%, Baseline (adaptation disabled))",0.0917219,0.0567568,-0.05,0,80,unavailable,4.8,3.6,3.9,"retina: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103599,IQCH,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1680% (minimum 80%, Supported); adrenal gland: 46.5217% (minimum 99%, Missing); amygdala: 75.0877% (minimum 99%, Missing); basal ganglia: 72.5424% (minimum 99%, Missing); bone marrow: 27.4711% (minimum 99%, Missing); cerebellum: 80.7547% (minimum 99%, Missing); cerebral cortex: 76.4286% (minimum 99%, Missing); choroid plexus: 64.0719% (minimum 99%, Missing); colon: 54.4529% (minimum 97%, Missing); duodenum: 52.9703% (minimum 99%, Missing); esophagus: 59.7765% (minimum 97%, Missing); heart muscle: 49.8834% (minimum 99%, Missing); hippocampal formation: 76.7025% (minimum 99%, Missing); hypothalamus: 76.1566% (minimum 99%, Missing); kidney: 48.5261% (minimum 99%, Missing); liver: 34.2400% (minimum 99%, Missing); lung: 53.7688% (minimum 99%, Missing); lymph node: 52.5799% (minimum 97%, Missing); midbrain: 74.3056% (minimum 99%, Missing); pancreas: 67.5079% (minimum 99%, Missing); parathyroid gland: 69.2557% (minimum 97%, Missing); pituitary gland: 76.7025% (minimum 99%, Missing); rectum: 58.1522% (minimum 97%, Missing); retina: 82.6255% (minimum 99%, Missing); salivary gland: 69.0323% (minimum 97%, Missing); skeletal muscle: 31.0595% (minimum 99%, Missing); skin: 64.8485% (minimum 95%, Missing); small intestine: 56.6138% (minimum 99%, Missing); smooth muscle: 71.0963% (minimum 97%, Supported); spinal cord: 76.4286% (minimum 99%, Missing); spleen: 54.5918% (minimum 95%, Missing); stomach: 63.3136% (minimum 97%, Missing); thymus: 70.6271% (minimum 95%, Missing); thyroid gland: 70.3947% (minimum 95%, Missing); tongue: 38.0107% (minimum 97%, Missing); urinary bladder: 52.9703% (minimum 97%, Missing)",-0.404082,-0.589893,-0.715289,0,9,partial,56.5,34.9,17.8,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 2); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); lymph node: 19.3 nTPM (protected, limit 2); urinary bladder: 19 nTPM (protected, limit 2); duodenum: 19 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 2); spleen: 17.8 nTPM (manageable, limit 5); adipose tissue: 16.7 nTPM (manageable, limit 15); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 2); esophagus: 14.4 nTPM (protected, limit 2); stomach: 12.4 nTPM (protected, limit 2); choroid plexus: 12 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); parathyroid gland: 9.5 nTPM (protected, limit 2); thyroid gland: 9 nTPM (manageable, limit 5); thymus: 8.9 nTPM (manageable, limit 5); smooth muscle: 8.7 nTPM (vital, limit 3); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103642,LACTB,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 46.5217% (minimum 75%, Missing); basal ganglia: 72.5424% (minimum 75%, Missing); bone marrow: 27.4711% (minimum 75%, Missing); choroid plexus: 64.0719% (minimum 75%, Missing); colon: 54.4529% (minimum 70%, Missing); duodenum: 52.9703% (minimum 75%, Missing); esophagus: 59.7765% (minimum 70%, Missing); heart muscle: 49.8834% (minimum 75%, Missing); kidney: 48.5261% (minimum 75%, Missing); liver: 34.2400% (minimum 75%, Missing); lung: 53.7688% (minimum 75%, Missing); lymph node: 52.5799% (minimum 70%, Missing); midbrain: 74.3056% (minimum 75%, Missing); pancreas: 67.5079% (minimum 75%, Missing); parathyroid gland: 69.2557% (minimum 70%, Missing); rectum: 58.1522% (minimum 70%, Missing); salivary gland: 69.0323% (minimum 70%, Missing); skeletal muscle: 31.0595% (minimum 75%, Missing); skin: 64.8485% (minimum 65%, Missing); small intestine: 56.6138% (minimum 75%, Missing); spleen: 54.5918% (minimum 65%, Missing); stomach: 63.3136% (minimum 70%, Missing); tongue: 38.0107% (minimum 70%, Missing); urinary bladder: 52.9703% (minimum 70%, Missing)",-0.104082,-0.319893,-0.475289,0,9,partial,56.5,34.9,17.8,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 2); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); lymph node: 19.3 nTPM (protected, limit 2); urinary bladder: 19 nTPM (protected, limit 2); duodenum: 19 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 2); spleen: 17.8 nTPM (manageable, limit 5); adipose tissue: 16.7 nTPM (manageable, limit 15); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 2); esophagus: 14.4 nTPM (protected, limit 2); stomach: 12.4 nTPM (protected, limit 2); choroid plexus: 12 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); parathyroid gland: 9.5 nTPM (protected, limit 2); thyroid gland: 9 nTPM (manageable, limit 5); thymus: 8.9 nTPM (manageable, limit 5); smooth muscle: 8.7 nTPM (vital, limit 3); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103642,LACTB,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 46.5217% (minimum 75%, Missing); basal ganglia: 72.5424% (minimum 75%, Missing); bone marrow: 27.4711% (minimum 75%, Missing); choroid plexus: 64.0719% (minimum 75%, Missing); colon: 54.4529% (minimum 70%, Missing); duodenum: 52.9703% (minimum 75%, Missing); esophagus: 59.7765% (minimum 70%, Missing); heart muscle: 49.8834% (minimum 75%, Missing); kidney: 48.5261% (minimum 75%, Missing); liver: 34.2400% (minimum 75%, Missing); lung: 53.7688% (minimum 75%, Missing); lymph node: 52.5799% (minimum 70%, Missing); midbrain: 74.3056% (minimum 75%, Missing); pancreas: 67.5079% (minimum 75%, Missing); parathyroid gland: 69.2557% (minimum 70%, Missing); rectum: 58.1522% (minimum 70%, Missing); salivary gland: 69.0323% (minimum 70%, Missing); skeletal muscle: 31.0595% (minimum 75%, Missing); skin: 64.8485% (minimum 65%, Missing); small intestine: 56.6138% (minimum 75%, Missing); spleen: 54.5918% (minimum 65%, Missing); stomach: 63.3136% (minimum 70%, Missing); tongue: 38.0107% (minimum 70%, Missing); urinary bladder: 52.9703% (minimum 70%, Missing)",-0.104082,-0.319893,-0.475289,0,9,partial,56.5,34.9,17.8,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 3); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); lymph node: 19.3 nTPM (protected, limit 3); urinary bladder: 19 nTPM (protected, limit 3); duodenum: 19 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 3); spleen: 17.8 nTPM (manageable, limit 5); adipose tissue: 16.7 nTPM (manageable, limit 15); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 3); esophagus: 14.4 nTPM (protected, limit 3); stomach: 12.4 nTPM (protected, limit 3); choroid plexus: 12 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); parathyroid gland: 9.5 nTPM (protected, limit 3); thyroid gland: 9 nTPM (manageable, limit 5); thymus: 8.9 nTPM (manageable, limit 5); smooth muscle: 8.7 nTPM (vital, limit 3); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103642,LACTB,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 46.5217% (minimum 75%, Missing); basal ganglia: 72.5424% (minimum 75%, Missing); bone marrow: 27.4711% (minimum 75%, Missing); choroid plexus: 64.0719% (minimum 75%, Missing); colon: 54.4529% (minimum 70%, Missing); duodenum: 52.9703% (minimum 75%, Missing); esophagus: 59.7765% (minimum 70%, Missing); heart muscle: 49.8834% (minimum 75%, Missing); kidney: 48.5261% (minimum 75%, Missing); liver: 34.2400% (minimum 75%, Missing); lung: 53.7688% (minimum 75%, Missing); lymph node: 52.5799% (minimum 70%, Missing); midbrain: 74.3056% (minimum 75%, Missing); pancreas: 67.5079% (minimum 75%, Missing); parathyroid gland: 69.2557% (minimum 70%, Missing); rectum: 58.1522% (minimum 70%, Missing); salivary gland: 69.0323% (minimum 70%, Missing); skeletal muscle: 31.0595% (minimum 75%, Missing); skin: 64.8485% (minimum 65%, Missing); small intestine: 56.6138% (minimum 75%, Missing); spleen: 54.5918% (minimum 65%, Missing); stomach: 63.3136% (minimum 70%, Missing); tongue: 38.0107% (minimum 70%, Missing); urinary bladder: 52.9703% (minimum 70%, Missing)",-0.104082,-0.319893,-0.475289,0,9,partial,56.5,34.9,17.8,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 3); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); lymph node: 19.3 nTPM (protected, limit 3); urinary bladder: 19 nTPM (protected, limit 3); duodenum: 19 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 3); spleen: 17.8 nTPM (manageable, limit 5); adipose tissue: 16.7 nTPM (manageable, limit 15); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 3); esophagus: 14.4 nTPM (protected, limit 3); stomach: 12.4 nTPM (protected, limit 3); choroid plexus: 12 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); parathyroid gland: 9.5 nTPM (protected, limit 3); thyroid gland: 9 nTPM (manageable, limit 5); thymus: 8.9 nTPM (manageable, limit 5); smooth muscle: 8.7 nTPM (vital, limit 3); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103642,LACTB,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1680% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 46.5217% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 72.5424% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 27.4711% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.0719% (minimum 75%, Baseline (adaptation disabled)); colon: 54.4529% (minimum 70%, Baseline (adaptation disabled)); duodenum: 52.9703% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.7765% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 49.8834% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.5261% (minimum 75%, Baseline (adaptation disabled)); liver: 34.2400% (minimum 75%, Baseline (adaptation disabled)); lung: 53.7688% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.5799% (minimum 70%, Baseline (adaptation disabled)); midbrain: 74.3056% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.5079% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.2557% (minimum 70%, Baseline (adaptation disabled)); rectum: 58.1522% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 69.0323% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 31.0595% (minimum 75%, Baseline (adaptation disabled)); skin: 64.8485% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.6138% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.0963% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.5918% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.3136% (minimum 70%, Baseline (adaptation disabled)); tongue: 38.0107% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.9703% (minimum 70%, Baseline (adaptation disabled))",-0.104082,-0.319893,-0.475289,0,9,partial,56.5,34.9,17.8,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 3); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); lymph node: 19.3 nTPM (protected, limit 3); urinary bladder: 19 nTPM (protected, limit 3); duodenum: 19 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 3); spleen: 17.8 nTPM (manageable, limit 5); adipose tissue: 16.7 nTPM (manageable, limit 5); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 3); esophagus: 14.4 nTPM (protected, limit 3); stomach: 12.4 nTPM (protected, limit 3); choroid plexus: 12 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); parathyroid gland: 9.5 nTPM (protected, limit 3); thyroid gland: 9 nTPM (manageable, limit 5); thymus: 8.9 nTPM (manageable, limit 5); smooth muscle: 8.7 nTPM (vital, limit 1); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103642,LACTB,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.2524% (minimum 99%, Missing); amygdala: 44.4444% (minimum 99%, Missing); basal ganglia: 36.8098% (minimum 99%, Missing); bone marrow: 88.2353% (minimum 95%, Enhanced); cerebellum: 11.8577% (minimum 99%, Missing); cerebral cortex: 17.8571% (minimum 99%, Missing); choroid plexus: 56.0748% (minimum 99%, Missing); colon: 85.7143% (minimum 97%, Missing); duodenum: 89.5522% (minimum 99%, Missing); hippocampal formation: 40.8163% (minimum 99%, Missing); hypothalamus: 31.9149% (minimum 99%, Missing); kidney: 90.9091% (minimum 95%, Enhanced); midbrain: 50.8475% (minimum 99%, Missing); pancreas: 75.0000% (minimum 95%, Enhanced); parathyroid gland: 32.7869% (minimum 97%, Missing); pituitary gland: 24.6914% (minimum 99%, Missing); rectum: 92.3077% (minimum 97%, Missing); retina: 15.8730% (minimum 99%, Missing); small intestine: 88.2353% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 95%, Enhanced); spinal cord: 56.6038% (minimum 99%, Missing); thymus: 86.9565% (minimum 95%, Missing); thyroid gland: 75.9494% (minimum 95%, Missing); tongue: 95.2381% (minimum 97%, Missing)",-0.190506,-0.642131,-0.871423,0,12,partial,44.6,12.3,1.9,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103723,AP3B2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.2524% (minimum 75%, Missing); amygdala: 44.4444% (minimum 75%, Missing); basal ganglia: 36.8098% (minimum 75%, Missing); cerebellum: 11.8577% (minimum 75%, Missing); cerebral cortex: 17.8571% (minimum 75%, Missing); choroid plexus: 56.0748% (minimum 75%, Missing); hippocampal formation: 40.8163% (minimum 75%, Missing); hypothalamus: 31.9149% (minimum 75%, Missing); midbrain: 50.8475% (minimum 75%, Missing); parathyroid gland: 32.7869% (minimum 70%, Missing); pituitary gland: 24.6914% (minimum 75%, Missing); retina: 15.8730% (minimum 75%, Missing); spinal cord: 56.6038% (minimum 75%, Missing)",0.109494,-0.372131,-0.631423,0,12,partial,44.6,12.3,1.9,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103723,AP3B2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.2524% (minimum 75%, Missing); amygdala: 44.4444% (minimum 75%, Missing); basal ganglia: 36.8098% (minimum 75%, Missing); cerebellum: 11.8577% (minimum 75%, Missing); cerebral cortex: 17.8571% (minimum 75%, Missing); choroid plexus: 56.0748% (minimum 75%, Missing); hippocampal formation: 40.8163% (minimum 75%, Missing); hypothalamus: 31.9149% (minimum 75%, Missing); midbrain: 50.8475% (minimum 75%, Missing); parathyroid gland: 32.7869% (minimum 70%, Missing); pituitary gland: 24.6914% (minimum 75%, Missing); retina: 15.8730% (minimum 75%, Missing); spinal cord: 56.6038% (minimum 75%, Missing)",0.109494,-0.372131,-0.631423,0,12,partial,44.6,12.3,1.9,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103723,AP3B2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.2524% (minimum 75%, Missing); amygdala: 44.4444% (minimum 75%, Missing); basal ganglia: 36.8098% (minimum 75%, Missing); cerebellum: 11.8577% (minimum 75%, Missing); cerebral cortex: 17.8571% (minimum 75%, Missing); choroid plexus: 56.0748% (minimum 75%, Missing); hippocampal formation: 40.8163% (minimum 75%, Missing); hypothalamus: 31.9149% (minimum 75%, Missing); midbrain: 50.8475% (minimum 75%, Missing); parathyroid gland: 32.7869% (minimum 70%, Missing); pituitary gland: 24.6914% (minimum 75%, Missing); retina: 15.8730% (minimum 75%, Missing); spinal cord: 56.6038% (minimum 75%, Missing)",0.109494,-0.372131,-0.631423,0,12,partial,44.6,12.3,1.9,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103723,AP3B2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.2524% (minimum 75%, Baseline (adaptation disabled)); amygdala: 44.4444% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 36.8098% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 11.8577% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 17.8571% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 56.0748% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 40.8163% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 31.9149% (minimum 75%, Baseline (adaptation disabled)); midbrain: 50.8475% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 32.7869% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 24.6914% (minimum 75%, Baseline (adaptation disabled)); retina: 15.8730% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.6038% (minimum 75%, Baseline (adaptation disabled))",0.109494,-0.372131,-0.631423,0,12,partial,44.6,12.3,1.9,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103723,AP3B2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.3559% (minimum 90%, Approved); adrenal gland: 88.0734% (minimum 98%, Approved); amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 91.4286% (minimum 99%, Missing); bone marrow: 37.2093% (minimum 98%, Approved); cerebellum: 89.7196% (minimum 99%, Missing); cerebral cortex: 92.3077% (minimum 99%, Missing); choroid plexus: 89.7196% (minimum 99%, Missing); colon: 81.3559% (minimum 97%, Missing); duodenum: 77.4194% (minimum 99%, Missing); esophagus: 79.3388% (minimum 95%, Approved); heart muscle: 82.0513% (minimum 98%, Approved); hippocampal formation: 94.1176% (minimum 99%, Missing); hypothalamus: 96.0000% (minimum 99%, Missing); kidney: 82.0513% (minimum 98%, Approved); liver: 90.5660% (minimum 98%, Approved); lung: 82.0513% (minimum 98%, Approved); lymph node: 69.5652% (minimum 95%, Approved); midbrain: 93.2039% (minimum 99%, Missing); pancreas: 76.8000% (minimum 99%, Missing); parathyroid gland: 88.0734% (minimum 95%, Approved); pituitary gland: 91.4286% (minimum 99%, Missing); rectum: 76.1905% (minimum 97%, Missing); retina: 84.2105% (minimum 99%, Missing); salivary gland: 80.6723% (minimum 97%, Missing); skeletal muscle: 90.5660% (minimum 98%, Approved); skin: 76.8000% (minimum 95%, Missing); small intestine: 76.8000% (minimum 99%, Missing); smooth muscle: 83.4783% (minimum 98%, Approved); spinal cord: 92.3077% (minimum 99%, Missing); spleen: 80.0000% (minimum 90%, Approved); stomach: 81.3559% (minimum 97%, Missing); thymus: 63.5762% (minimum 95%, Missing); thyroid gland: 77.4194% (minimum 90%, Approved); tongue: 94.1176% (minimum 97%, Missing); urinary bladder: 88.0734% (minimum 97%, Missing)",-0.314238,-0.254348,-0.607907,0,3,partial,16.2,4.2,5.5,"bone marrow: 16.2 nTPM (vital, limit 2); thymus: 5.5 nTPM (manageable, limit 5); lymph node: 4.2 nTPM (protected, limit 4); rectum: 3 nTPM (protected, limit 2); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 2); kidney: 2.1 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 2); retina: 1.8 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103995,CEP152,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 37.2093% (minimum 70%, Approved); thymus: 63.5762% (minimum 65%, Missing)",-0.0142384,0.0456522,-0.327907,0,3,partial,16.2,4.2,5.5,"bone marrow: 16.2 nTPM (vital, limit 2); thymus: 5.5 nTPM (manageable, limit 5); lymph node: 4.2 nTPM (protected, limit 4); rectum: 3 nTPM (protected, limit 2); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 2); kidney: 2.1 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 2); retina: 1.8 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103995,CEP152,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 37.2093% (minimum 70%, Approved); thymus: 63.5762% (minimum 65%, Missing)",-0.0142384,0.0456522,-0.327907,0,3,partial,16.2,4.2,5.5,"bone marrow: 16.2 nTPM (vital, limit 2); thymus: 5.5 nTPM (manageable, limit 5); lymph node: 4.2 nTPM (protected, limit 4); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 2); kidney: 2.1 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 2); retina: 1.8 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103995,CEP152,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 37.2093% (minimum 70%, Approved); thymus: 63.5762% (minimum 65%, Missing)",-0.0142384,0.0456522,-0.327907,0,3,partial,16.2,4.2,5.5,"bone marrow: 16.2 nTPM (vital, limit 2); thymus: 5.5 nTPM (manageable, limit 5); lymph node: 4.2 nTPM (protected, limit 4); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 2); kidney: 2.1 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 2); retina: 1.8 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103995,CEP152,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 37.2093% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.5652% (minimum 70%, Baseline (adaptation disabled)); thymus: 63.5762% (minimum 65%, Baseline (adaptation disabled))",-0.0142384,-0.00434783,-0.377907,0,3,partial,16.2,4.2,5.5,"bone marrow: 16.2 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); lymph node: 4.2 nTPM (protected, limit 3); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000103995,CEP152,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.6941% (minimum 95%, Enhanced); amygdala: 98.5437% (minimum 99%, Missing); basal ganglia: 98.5437% (minimum 99%, Missing); bone marrow: 66.5574% (minimum 95%, Enhanced); duodenum: 85.6540% (minimum 95%, Enhanced); heart muscle: 93.5484% (minimum 95%, Enhanced); hippocampal formation: 98.5437% (minimum 99%, Missing); liver: 94.4186% (minimum 95%, Enhanced); lymph node: 78.3784% (minimum 80%, Enhanced); midbrain: 98.5437% (minimum 99%, Missing); pancreas: 98.5437% (minimum 99%, Missing); retina: 96.6667% (minimum 99%, Missing); skeletal muscle: 67.2185% (minimum 95%, Enhanced); small intestine: 84.2324% (minimum 95%, Enhanced); spinal cord: 97.5962% (minimum 99%, Missing); thymus: 69.7595% (minimum 95%, Missing); tongue: 96.6667% (minimum 97%, Missing)",-0.252405,-0.0162162,-0.284426,0,3,partial,10.2,5.6,8.8,"bone marrow: 10.2 nTPM (vital, limit 6); skeletal muscle: 9.9 nTPM (vital, limit 6); thymus: 8.8 nTPM (manageable, limit 5)",pancreas / exocrine glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104147,OIP5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0475945,0.233784,0.0655738,0,3,partial,10.2,5.6,8.8,"bone marrow: 10.2 nTPM (vital, limit 6); skeletal muscle: 9.9 nTPM (vital, limit 6); thymus: 8.8 nTPM (manageable, limit 5)",pancreas / exocrine glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104147,OIP5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0475945,0.233784,0.0655738,0,3,partial,10.2,5.6,8.8,"bone marrow: 10.2 nTPM (vital, limit 6); skeletal muscle: 9.9 nTPM (vital, limit 6); thymus: 8.8 nTPM (manageable, limit 5)",pancreas / exocrine glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104147,OIP5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0475945,0.233784,0.0655738,0,3,partial,10.2,5.6,8.8,"bone marrow: 10.2 nTPM (vital, limit 6); skeletal muscle: 9.9 nTPM (vital, limit 6); thymus: 8.8 nTPM (manageable, limit 5)",pancreas / exocrine glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104147,OIP5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 66.5574% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 67.2185% (minimum 75%, Baseline (adaptation disabled))",0.0475945,0.0837838,-0.0844262,0,3,partial,10.2,5.6,8.8,"bone marrow: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3); colon: 4 nTPM (protected, limit 3); rectum: 3.8 nTPM (protected, limit 3); small intestine: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104147,OIP5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.2195% (minimum 95%, Missing); adrenal gland: 81.6993% (minimum 99%, Missing); amygdala: 75.7576% (minimum 99%, Missing); basal ganglia: 71.4286% (minimum 99%, Missing); bone marrow: 92.5926% (minimum 99%, Missing); cerebellum: 64.1026% (minimum 99%, Missing); cerebral cortex: 75.7576% (minimum 99%, Missing); choroid plexus: 76.6871% (minimum 99%, Missing); colon: 75.7576% (minimum 97%, Missing); duodenum: 85.0340% (minimum 99%, Missing); esophagus: 79.1139% (minimum 97%, Missing); heart muscle: 77.6398% (minimum 99%, Missing); hippocampal formation: 72.2543% (minimum 99%, Missing); hypothalamus: 71.4286% (minimum 99%, Missing); kidney: 70.2247% (minimum 99%, Missing); liver: 70.2247% (minimum 99%, Missing); lung: 69.0608% (minimum 99%, Missing); lymph node: 89.2857% (minimum 97%, Missing); midbrain: 77.6398% (minimum 99%, Missing); pancreas: 68.3060% (minimum 99%, Missing); parathyroid gland: 75.3012% (minimum 97%, Missing); pituitary gland: 79.6178% (minimum 99%, Missing); rectum: 82.2368% (minimum 97%, Missing); retina: 85.0340% (minimum 99%, Missing); salivary gland: 78.1250% (minimum 97%, Missing); skeletal muscle: 48.8281% (minimum 99%, Missing); skin: 78.1250% (minimum 95%, Missing); small intestine: 76.6871% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spinal cord: 74.4048% (minimum 99%, Missing); spleen: 79.1139% (minimum 95%, Missing); stomach: 74.8503% (minimum 97%, Missing); thymus: 76.6871% (minimum 95%, Missing); thyroid gland: 73.5294% (minimum 95%, Missing); tongue: 82.2368% (minimum 97%, Missing); urinary bladder: 76.2195% (minimum 97%, Missing)",-0.214706,-0.221497,-0.501719,0,80,unavailable,13.1,4.2,4.5,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); parathyroid gland: 4.1 nTPM (protected, limit 2); cerebral cortex: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); small intestine: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); tongue: 2.7 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104218,CSPP1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing); cerebellum: 64.1026% (minimum 75%, Missing); hippocampal formation: 72.2543% (minimum 75%, Missing); hypothalamus: 71.4286% (minimum 75%, Missing); kidney: 70.2247% (minimum 75%, Missing); liver: 70.2247% (minimum 75%, Missing); lung: 69.0608% (minimum 75%, Missing); pancreas: 68.3060% (minimum 75%, Missing); skeletal muscle: 48.8281% (minimum 75%, Missing); spinal cord: 74.4048% (minimum 75%, Missing)",0.0852941,0.048503,-0.261719,0,80,unavailable,13.1,4.2,4.5,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); parathyroid gland: 4.1 nTPM (protected, limit 2); cerebral cortex: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); small intestine: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); tongue: 2.7 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104218,CSPP1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing); cerebellum: 64.1026% (minimum 75%, Missing); hippocampal formation: 72.2543% (minimum 75%, Missing); hypothalamus: 71.4286% (minimum 75%, Missing); kidney: 70.2247% (minimum 75%, Missing); liver: 70.2247% (minimum 75%, Missing); lung: 69.0608% (minimum 75%, Missing); pancreas: 68.3060% (minimum 75%, Missing); skeletal muscle: 48.8281% (minimum 75%, Missing); spinal cord: 74.4048% (minimum 75%, Missing)",0.0852941,0.048503,-0.261719,0,80,unavailable,13.1,4.2,4.5,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); parathyroid gland: 4.1 nTPM (protected, limit 3); cerebral cortex: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); small intestine: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104218,CSPP1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing); cerebellum: 64.1026% (minimum 75%, Missing); hippocampal formation: 72.2543% (minimum 75%, Missing); hypothalamus: 71.4286% (minimum 75%, Missing); kidney: 70.2247% (minimum 75%, Missing); liver: 70.2247% (minimum 75%, Missing); lung: 69.0608% (minimum 75%, Missing); pancreas: 68.3060% (minimum 75%, Missing); skeletal muscle: 48.8281% (minimum 75%, Missing); spinal cord: 74.4048% (minimum 75%, Missing)",0.0852941,0.048503,-0.261719,0,80,unavailable,13.1,4.2,4.5,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); parathyroid gland: 4.1 nTPM (protected, limit 3); cerebral cortex: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); small intestine: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104218,CSPP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.1026% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.2543% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.4286% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.2247% (minimum 75%, Baseline (adaptation disabled)); liver: 70.2247% (minimum 75%, Baseline (adaptation disabled)); lung: 69.0608% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.3060% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 48.8281% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.4048% (minimum 75%, Baseline (adaptation disabled))",0.0852941,0.048503,-0.261719,0,80,unavailable,13.1,4.2,4.5,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); parathyroid gland: 4.1 nTPM (protected, limit 3); cerebral cortex: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); small intestine: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104218,CSPP1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 67.6471% (minimum 90%, Approved); adrenal gland: 80.7018% (minimum 98%, Approved); amygdala: 95.8333% (minimum 99%, Missing); basal ganglia: 95.8333% (minimum 99%, Missing); bone marrow: 68.6567% (minimum 98%, Approved); cerebellum: 85.1852% (minimum 98%, Approved); cerebral cortex: 93.8776% (minimum 98%, Approved); choroid plexus: 95.8333% (minimum 99%, Missing); colon: 48.4211% (minimum 95%, Approved); duodenum: 41.4414% (minimum 98%, Approved); esophagus: 57.5000% (minimum 95%, Approved); heart muscle: 90.1961% (minimum 98%, Approved); hippocampal formation: 95.8333% (minimum 99%, Missing); hypothalamus: 93.8776% (minimum 99%, Missing); kidney: 76.6667% (minimum 98%, Approved); liver: 53.4884% (minimum 98%, Approved); lung: 58.9744% (minimum 98%, Approved); lymph node: 35.1145% (minimum 95%, Approved); midbrain: 95.8333% (minimum 99%, Missing); pancreas: 82.1429% (minimum 98%, Approved); pituitary gland: 90.1961% (minimum 99%, Missing); rectum: 51.6854% (minimum 95%, Approved); retina: 86.7925% (minimum 99%, Missing); salivary gland: 80.7018% (minimum 95%, Approved); skeletal muscle: 97.8723% (minimum 98%, Approved); skin: 35.1145% (minimum 90%, Approved); small intestine: 35.1145% (minimum 98%, Approved); smooth muscle: 80.7018% (minimum 98%, Approved); spinal cord: 95.8333% (minimum 99%, Missing); spleen: 57.5000% (minimum 90%, Approved); stomach: 55.4217% (minimum 95%, Approved); thymus: 85.1852% (minimum 95%, Missing); thyroid gland: 79.3103% (minimum 90%, Approved); urinary bladder: 63.0137% (minimum 95%, Approved)",-0.548855,-0.598855,-0.628855,0,6,partial,8.5,8.5,8.5,"lymph node: 8.5 nTPM (protected, limit 4); small intestine: 8.5 nTPM (vital, limit 2); duodenum: 6.5 nTPM (vital, limit 2); colon: 4.9 nTPM (protected, limit 4); rectum: 4.3 nTPM (protected, limit 4); liver: 4 nTPM (vital, limit 2); lung: 3.2 nTPM (vital, limit 2); bone marrow: 2.1 nTPM (vital, limit 2)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104432,IL7,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.6567% (minimum 70%, Approved); colon: 48.4211% (minimum 65%, Approved); duodenum: 41.4414% (minimum 70%, Approved); esophagus: 57.5000% (minimum 65%, Approved); liver: 53.4884% (minimum 70%, Approved); lung: 58.9744% (minimum 70%, Approved); lymph node: 35.1145% (minimum 65%, Approved); rectum: 51.6854% (minimum 65%, Approved); skin: 35.1145% (minimum 60%, Approved); small intestine: 35.1145% (minimum 70%, Approved); spleen: 57.5000% (minimum 60%, Approved); stomach: 55.4217% (minimum 65%, Approved); urinary bladder: 63.0137% (minimum 65%, Approved)",-0.248855,-0.298855,-0.348855,0,6,partial,8.5,8.5,8.5,"lymph node: 8.5 nTPM (protected, limit 4); small intestine: 8.5 nTPM (vital, limit 2); duodenum: 6.5 nTPM (vital, limit 2); colon: 4.9 nTPM (protected, limit 4); rectum: 4.3 nTPM (protected, limit 4); liver: 4 nTPM (vital, limit 2); lung: 3.2 nTPM (vital, limit 2); bone marrow: 2.1 nTPM (vital, limit 2)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104432,IL7,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.6567% (minimum 70%, Approved); colon: 48.4211% (minimum 65%, Approved); duodenum: 41.4414% (minimum 70%, Approved); esophagus: 57.5000% (minimum 65%, Approved); liver: 53.4884% (minimum 70%, Approved); lung: 58.9744% (minimum 70%, Approved); lymph node: 35.1145% (minimum 65%, Approved); rectum: 51.6854% (minimum 65%, Approved); skin: 35.1145% (minimum 60%, Approved); small intestine: 35.1145% (minimum 70%, Approved); spleen: 57.5000% (minimum 60%, Approved); stomach: 55.4217% (minimum 65%, Approved); urinary bladder: 63.0137% (minimum 65%, Approved)",-0.248855,-0.298855,-0.348855,0,6,partial,8.5,8.5,8.5,"lymph node: 8.5 nTPM (protected, limit 4); small intestine: 8.5 nTPM (vital, limit 2); duodenum: 6.5 nTPM (vital, limit 2); colon: 4.9 nTPM (protected, limit 4); rectum: 4.3 nTPM (protected, limit 4); liver: 4 nTPM (vital, limit 2); lung: 3.2 nTPM (vital, limit 2); bone marrow: 2.1 nTPM (vital, limit 2)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104432,IL7,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.6567% (minimum 70%, Approved); colon: 48.4211% (minimum 65%, Approved); duodenum: 41.4414% (minimum 70%, Approved); esophagus: 57.5000% (minimum 65%, Approved); liver: 53.4884% (minimum 70%, Approved); lung: 58.9744% (minimum 70%, Approved); lymph node: 35.1145% (minimum 65%, Approved); rectum: 51.6854% (minimum 65%, Approved); skin: 35.1145% (minimum 60%, Approved); small intestine: 35.1145% (minimum 70%, Approved); spleen: 57.5000% (minimum 60%, Approved); stomach: 55.4217% (minimum 65%, Approved); urinary bladder: 63.0137% (minimum 65%, Approved)",-0.248855,-0.298855,-0.348855,0,6,partial,8.5,8.5,8.5,"lymph node: 8.5 nTPM (protected, limit 4); small intestine: 8.5 nTPM (vital, limit 2); duodenum: 6.5 nTPM (vital, limit 2); colon: 4.9 nTPM (protected, limit 4); rectum: 4.3 nTPM (protected, limit 4); liver: 4 nTPM (vital, limit 2); lung: 3.2 nTPM (vital, limit 2); bone marrow: 2.1 nTPM (vital, limit 2)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104432,IL7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.6567% (minimum 75%, Baseline (adaptation disabled)); colon: 48.4211% (minimum 70%, Baseline (adaptation disabled)); duodenum: 41.4414% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.5000% (minimum 70%, Baseline (adaptation disabled)); liver: 53.4884% (minimum 75%, Baseline (adaptation disabled)); lung: 58.9744% (minimum 75%, Baseline (adaptation disabled)); lymph node: 35.1145% (minimum 70%, Baseline (adaptation disabled)); rectum: 51.6854% (minimum 70%, Baseline (adaptation disabled)); skin: 35.1145% (minimum 65%, Baseline (adaptation disabled)); small intestine: 35.1145% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.5000% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.4217% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.0137% (minimum 70%, Baseline (adaptation disabled))",-0.298855,-0.348855,-0.398855,0,6,partial,8.5,8.5,8.5,"lymph node: 8.5 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.5 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 3); rectum: 4.3 nTPM (protected, limit 3); liver: 4 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); esophagus: 3.4 nTPM (protected, limit 3); lung: 3.2 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104432,IL7,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.5644% (minimum 95%, Enhanced); amygdala: 88.3178% (minimum 99%, Missing); basal ganglia: 83.6283% (minimum 99%, Missing); bone marrow: 65.3979% (minimum 99%, Missing); cerebellum: 82.1739% (minimum 95%, Enhanced); cerebral cortex: 87.9070% (minimum 95%, Enhanced); choroid plexus: 64.0678% (minimum 99%, Missing); colon: 60.3834% (minimum 80%, Enhanced); duodenum: 87.0968% (minimum 95%, Enhanced); esophagus: 71.3208% (minimum 80%, Enhanced); heart muscle: 93.1034% (minimum 95%, Enhanced); hippocampal formation: 85.9091% (minimum 99%, Missing); hypothalamus: 82.1739% (minimum 99%, Missing); kidney: 85.9091% (minimum 95%, Enhanced); liver: 80.4255% (minimum 95%, Enhanced); lung: 79.4118% (minimum 95%, Enhanced); midbrain: 87.0968% (minimum 99%, Missing); pancreas: 88.7324% (minimum 95%, Enhanced); parathyroid gland: 68.4783% (minimum 80%, Enhanced); pituitary gland: 77.4590% (minimum 99%, Missing); rectum: 51.6393% (minimum 97%, Missing); retina: 91.3043% (minimum 99%, Missing); skeletal muscle: 97.9275% (minimum 99%, Missing); small intestine: 87.9070% (minimum 99%, Missing); smooth muscle: 91.3043% (minimum 99%, Missing); spinal cord: 88.7324% (minimum 99%, Missing); stomach: 75.2988% (minimum 80%, Enhanced); thymus: 90.4306% (minimum 95%, Missing); urinary bladder: 78.7500% (minimum 80%, Enhanced)",-0.0456938,-0.453607,-0.349322,0,5,partial,10.6,17.7,7.7,"rectum: 17.7 nTPM (protected, limit 2); colon: 12.4 nTPM (protected, limit 12); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104450,SPAG1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 65.3979% (minimum 75%, Missing); choroid plexus: 64.0678% (minimum 75%, Missing); rectum: 51.6393% (minimum 70%, Missing)",0.210526,-0.183607,-0.109322,0,5,partial,10.6,17.7,7.7,"rectum: 17.7 nTPM (protected, limit 2); colon: 12.4 nTPM (protected, limit 12); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104450,SPAG1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 65.3979% (minimum 75%, Missing); choroid plexus: 64.0678% (minimum 75%, Missing); rectum: 51.6393% (minimum 70%, Missing)",0.210526,-0.183607,-0.109322,0,5,partial,10.6,17.7,7.7,"rectum: 17.7 nTPM (protected, limit 3); colon: 12.4 nTPM (protected, limit 12); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104450,SPAG1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 65.3979% (minimum 75%, Missing); choroid plexus: 64.0678% (minimum 75%, Missing); rectum: 51.6393% (minimum 70%, Missing)",0.210526,-0.183607,-0.109322,0,5,partial,10.6,17.7,7.7,"rectum: 17.7 nTPM (protected, limit 3); colon: 12.4 nTPM (protected, limit 12); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104450,SPAG1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 65.3979% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.0678% (minimum 75%, Baseline (adaptation disabled)); colon: 60.3834% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 68.4783% (minimum 70%, Baseline (adaptation disabled)); rectum: 51.6393% (minimum 70%, Baseline (adaptation disabled))",0.0605263,-0.183607,-0.109322,0,5,partial,10.6,17.7,7.7,"rectum: 17.7 nTPM (protected, limit 3); colon: 12.4 nTPM (protected, limit 3); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); parathyroid gland: 8.7 nTPM (protected, limit 3); skin: 7.7 nTPM (manageable, limit 5); esophagus: 7.6 nTPM (protected, limit 3); stomach: 6.2 nTPM (protected, limit 3); pituitary gland: 5.5 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 3); lung: 4.9 nTPM (vital, limit 1); liver: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); hypothalamus: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104450,SPAG1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8326% (minimum 95%, Missing); adrenal gland: 74.0933% (minimum 99%, Missing); amygdala: 79.0055% (minimum 99%, Missing); basal ganglia: 80.3371% (minimum 99%, Missing); bone marrow: 57.8947% (minimum 99%, Missing); cerebellum: 77.7174% (minimum 99%, Missing); cerebral cortex: 74.0933% (minimum 99%, Missing); choroid plexus: 91.0828% (minimum 99%, Missing); colon: 70.4433% (minimum 97%, Missing); duodenum: 69.7561% (minimum 99%, Missing); esophagus: 46.8852% (minimum 97%, Missing); heart muscle: 64.7059% (minimum 99%, Missing); hippocampal formation: 77.2973% (minimum 99%, Missing); hypothalamus: 71.5000% (minimum 99%, Missing); kidney: 69.0821% (minimum 99%, Missing); liver: 72.9592% (minimum 99%, Missing); lung: 68.7500% (minimum 99%, Missing); lymph node: 74.4792% (minimum 97%, Missing); midbrain: 69.0821% (minimum 99%, Missing); pancreas: 82.6590% (minimum 99%, Missing); parathyroid gland: 62.4454% (minimum 97%, Missing); pituitary gland: 79.8883% (minimum 99%, Missing); rectum: 69.4175% (minimum 97%, Missing); retina: 75.2632% (minimum 99%, Missing); salivary gland: 72.2222% (minimum 97%, Missing); skeletal muscle: 76.4706% (minimum 99%, Missing); skin: 56.7460% (minimum 95%, Missing); small intestine: 72.2222% (minimum 99%, Missing); smooth muscle: 55.6420% (minimum 99%, Missing); spinal cord: 68.7500% (minimum 99%, Missing); spleen: 55.0000% (minimum 95%, Missing); stomach: 62.1739% (minimum 97%, Missing); thymus: 60.8511% (minimum 95%, Missing); thyroid gland: 62.9956% (minimum 95%, Missing); tongue: 61.6379% (minimum 97%, Missing); urinary bladder: 67.7725% (minimum 97%, Missing)",-0.4,-0.501148,-0.43358,0,5,partial,11.4,16.2,11.7,"esophagus: 16.2 nTPM (protected, limit 2); spleen: 11.7 nTPM (manageable, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); bone marrow: 10.4 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); tongue: 8.9 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); parathyroid gland: 8.6 nTPM (protected, limit 2); thyroid gland: 8.4 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); hypothalamus: 5.7 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 2); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104497,SNX16,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8326% (minimum 65%, Missing); adrenal gland: 74.0933% (minimum 75%, Missing); bone marrow: 57.8947% (minimum 75%, Missing); cerebral cortex: 74.0933% (minimum 75%, Missing); duodenum: 69.7561% (minimum 75%, Missing); esophagus: 46.8852% (minimum 70%, Missing); heart muscle: 64.7059% (minimum 75%, Missing); hypothalamus: 71.5000% (minimum 75%, Missing); kidney: 69.0821% (minimum 75%, Missing); liver: 72.9592% (minimum 75%, Missing); lung: 68.7500% (minimum 75%, Missing); midbrain: 69.0821% (minimum 75%, Missing); parathyroid gland: 62.4454% (minimum 70%, Missing); rectum: 69.4175% (minimum 70%, Missing); skin: 56.7460% (minimum 65%, Missing); small intestine: 72.2222% (minimum 75%, Missing); smooth muscle: 55.6420% (minimum 75%, Missing); spinal cord: 68.7500% (minimum 75%, Missing); spleen: 55.0000% (minimum 65%, Missing); stomach: 62.1739% (minimum 70%, Missing); thymus: 60.8511% (minimum 65%, Missing); thyroid gland: 62.9956% (minimum 65%, Missing); tongue: 61.6379% (minimum 70%, Missing); urinary bladder: 67.7725% (minimum 70%, Missing)",-0.1,-0.231148,-0.19358,0,5,partial,11.4,16.2,11.7,"esophagus: 16.2 nTPM (protected, limit 2); spleen: 11.7 nTPM (manageable, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); bone marrow: 10.4 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); tongue: 8.9 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); parathyroid gland: 8.6 nTPM (protected, limit 2); thyroid gland: 8.4 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); hypothalamus: 5.7 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 2); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104497,SNX16,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8326% (minimum 65%, Missing); adrenal gland: 74.0933% (minimum 75%, Missing); bone marrow: 57.8947% (minimum 75%, Missing); cerebral cortex: 74.0933% (minimum 75%, Missing); duodenum: 69.7561% (minimum 75%, Missing); esophagus: 46.8852% (minimum 70%, Missing); heart muscle: 64.7059% (minimum 75%, Missing); hypothalamus: 71.5000% (minimum 75%, Missing); kidney: 69.0821% (minimum 75%, Missing); liver: 72.9592% (minimum 75%, Missing); lung: 68.7500% (minimum 75%, Missing); midbrain: 69.0821% (minimum 75%, Missing); parathyroid gland: 62.4454% (minimum 70%, Missing); rectum: 69.4175% (minimum 70%, Missing); skin: 56.7460% (minimum 65%, Missing); small intestine: 72.2222% (minimum 75%, Missing); smooth muscle: 55.6420% (minimum 75%, Missing); spinal cord: 68.7500% (minimum 75%, Missing); spleen: 55.0000% (minimum 65%, Missing); stomach: 62.1739% (minimum 70%, Missing); thymus: 60.8511% (minimum 65%, Missing); thyroid gland: 62.9956% (minimum 65%, Missing); tongue: 61.6379% (minimum 70%, Missing); urinary bladder: 67.7725% (minimum 70%, Missing)",-0.1,-0.231148,-0.19358,0,5,partial,11.4,16.2,11.7,"esophagus: 16.2 nTPM (protected, limit 3); spleen: 11.7 nTPM (manageable, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); bone marrow: 10.4 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); tongue: 8.9 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); parathyroid gland: 8.6 nTPM (protected, limit 3); thyroid gland: 8.4 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); hypothalamus: 5.7 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 3); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104497,SNX16,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8326% (minimum 65%, Missing); adrenal gland: 74.0933% (minimum 75%, Missing); bone marrow: 57.8947% (minimum 75%, Missing); cerebral cortex: 74.0933% (minimum 75%, Missing); duodenum: 69.7561% (minimum 75%, Missing); esophagus: 46.8852% (minimum 70%, Missing); heart muscle: 64.7059% (minimum 75%, Missing); hypothalamus: 71.5000% (minimum 75%, Missing); kidney: 69.0821% (minimum 75%, Missing); liver: 72.9592% (minimum 75%, Missing); lung: 68.7500% (minimum 75%, Missing); midbrain: 69.0821% (minimum 75%, Missing); parathyroid gland: 62.4454% (minimum 70%, Missing); rectum: 69.4175% (minimum 70%, Missing); skin: 56.7460% (minimum 65%, Missing); small intestine: 72.2222% (minimum 75%, Missing); smooth muscle: 55.6420% (minimum 75%, Missing); spinal cord: 68.7500% (minimum 75%, Missing); spleen: 55.0000% (minimum 65%, Missing); stomach: 62.1739% (minimum 70%, Missing); thymus: 60.8511% (minimum 65%, Missing); thyroid gland: 62.9956% (minimum 65%, Missing); tongue: 61.6379% (minimum 70%, Missing); urinary bladder: 67.7725% (minimum 70%, Missing)",-0.1,-0.231148,-0.19358,0,5,partial,11.4,16.2,11.7,"esophagus: 16.2 nTPM (protected, limit 3); spleen: 11.7 nTPM (manageable, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); bone marrow: 10.4 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); tongue: 8.9 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); parathyroid gland: 8.6 nTPM (protected, limit 3); thyroid gland: 8.4 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); hypothalamus: 5.7 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 3); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104497,SNX16,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8326% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 74.0933% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 57.8947% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.0933% (minimum 75%, Baseline (adaptation disabled)); duodenum: 69.7561% (minimum 75%, Baseline (adaptation disabled)); esophagus: 46.8852% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.7059% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.5000% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.0821% (minimum 75%, Baseline (adaptation disabled)); liver: 72.9592% (minimum 75%, Baseline (adaptation disabled)); lung: 68.7500% (minimum 75%, Baseline (adaptation disabled)); midbrain: 69.0821% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.4454% (minimum 70%, Baseline (adaptation disabled)); rectum: 69.4175% (minimum 70%, Baseline (adaptation disabled)); skin: 56.7460% (minimum 65%, Baseline (adaptation disabled)); small intestine: 72.2222% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.6420% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.7500% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.1739% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.8511% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.9956% (minimum 65%, Baseline (adaptation disabled)); tongue: 61.6379% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.7725% (minimum 70%, Baseline (adaptation disabled))",-0.1,-0.231148,-0.19358,0,5,partial,11.4,16.2,11.7,"esophagus: 16.2 nTPM (protected, limit 3); spleen: 11.7 nTPM (manageable, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); bone marrow: 10.4 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); tongue: 8.9 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); parathyroid gland: 8.6 nTPM (protected, limit 3); thyroid gland: 8.4 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); hypothalamus: 5.7 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 3); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104497,SNX16,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 1.7314% (minimum 99%, Missing); pancreas: 97.0588% (minimum 99%, Missing)",0.05,0.03,-0.972686,0,80,unavailable,187.3,0,0,"adrenal gland: 187.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104499,GML,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 1.7314% (minimum 75%, Missing)",0.35,0.3,-0.732686,0,80,unavailable,187.3,0,0,"adrenal gland: 187.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104499,GML,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 1.7314% (minimum 75%, Missing)",0.35,0.3,-0.732686,0,80,unavailable,187.3,0,0,"adrenal gland: 187.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104499,GML,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 1.7314% (minimum 75%, Missing)",0.35,0.3,-0.732686,0,80,unavailable,187.3,0,0,"adrenal gland: 187.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104499,GML,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 1.7314% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.732686,0,80,unavailable,187.3,0,0,"adrenal gland: 187.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104499,GML,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104755,ADAM2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104755,ADAM2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104755,ADAM2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104755,ADAM2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104755,ADAM2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.7492% (minimum 99%, Missing)",0.021246,0.020228,-0.012508,0,80,unavailable,0.7,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104804,TULP2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.321246,0.290228,0.227492,0,80,unavailable,0.7,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104804,TULP2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.321246,0.290228,0.227492,0,80,unavailable,0.7,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104804,TULP2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.321246,0.290228,0.227492,0,80,unavailable,0.7,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104804,TULP2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.321246,0.290228,0.227492,0,80,unavailable,0.7,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104804,TULP2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 93.7500% (minimum 97%, Supported); amygdala: 88.2353% (minimum 99%, Missing); basal ganglia: 71.4286% (minimum 99%, Missing); cerebral cortex: 93.7500% (minimum 97%, Supported); esophagus: 88.2353% (minimum 90%, Supported); heart muscle: 93.7500% (minimum 97%, Supported); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 83.3333% (minimum 99%, Missing); kidney: 93.7500% (minimum 97%, Supported); midbrain: 93.7500% (minimum 99%, Missing); pituitary gland: 78.9474% (minimum 99%, Missing); retina: 93.7500% (minimum 99%, Missing); skeletal muscle: 93.7500% (minimum 97%, Supported)",0.05,-0.0176471,-0.275714,0,1,partial,0.6,0.2,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104818,CGB2,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing)",0.332353,0.282353,-0.0357143,0,1,partial,0.6,0.2,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104818,CGB2,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing)",0.332353,0.282353,-0.0357143,0,1,partial,0.6,0.2,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104818,CGB2,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing)",0.332353,0.282353,-0.0357143,0,1,partial,0.6,0.2,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104818,CGB2,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Baseline (adaptation disabled))",0.232353,0.182353,-0.0357143,0,1,partial,0.6,0.2,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104818,CGB2,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 81.1966% (minimum 95%, Enhanced); pituitary gland: 82.6087% (minimum 99%, Missing)",0.05,0.03,-0.163913,0,2,partial,2.2,0.2,0.1,"pituitary gland: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104827,CGB3,admission_only,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.076087,0,2,partial,2.2,0.2,0.1,"pituitary gland: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104827,CGB3,selectivity_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.076087,0,2,partial,2.2,0.2,0.1,"pituitary gland: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104827,CGB3,grid_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.076087,0,2,partial,2.2,0.2,0.1,"pituitary gland: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104827,CGB3,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339583,0.279381,0.0619658,0,2,partial,2.2,0.2,0.1,"pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104827,CGB3,current_fixed,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6316% (minimum 90%, Approved); adrenal gland: 41.4634% (minimum 99%, Missing); amygdala: 60.4061% (minimum 99%, Missing); basal ganglia: 58.6207% (minimum 99%, Missing); bone marrow: 56.3981% (minimum 99%, Missing); cerebellum: 52.1930% (minimum 99%, Missing); cerebral cortex: 48.3740% (minimum 99%, Missing); choroid plexus: 60.7143% (minimum 99%, Missing); colon: 54.8387% (minimum 97%, Missing); duodenum: 56.9378% (minimum 99%, Missing); esophagus: 46.1240% (minimum 97%, Missing); heart muscle: 49.7908% (minimum 99%, Missing); hippocampal formation: 58.9109% (minimum 99%, Missing); hypothalamus: 58.6207% (minimum 99%, Missing); kidney: 45.5939% (minimum 99%, Missing); liver: 39.5349% (minimum 99%, Missing); lung: 65.0273% (minimum 99%, Missing); lymph node: 55.3488% (minimum 97%, Missing); midbrain: 62.3037% (minimum 99%, Missing); pancreas: 43.4307% (minimum 99%, Missing); parathyroid gland: 61.3402% (minimum 97%, Missing); pituitary gland: 50.6383% (minimum 99%, Missing); rectum: 70.0000% (minimum 97%, Missing); retina: 84.3972% (minimum 99%, Missing); salivary gland: 51.9651% (minimum 97%, Missing); skeletal muscle: 42.8058% (minimum 99%, Missing); skin: 49.7908% (minimum 95%, Missing); small intestine: 54.5872% (minimum 99%, Missing); smooth muscle: 70.4142% (minimum 99%, Missing); spinal cord: 61.9792% (minimum 99%, Missing); spleen: 50.4237% (minimum 95%, Missing); stomach: 50.6383% (minimum 97%, Missing); thymus: 61.9792% (minimum 95%, Missing); thyroid gland: 46.1240% (minimum 95%, Missing); tongue: 51.7391% (minimum 97%, Missing); urinary bladder: 56.6667% (minimum 97%, Missing)",-0.48876,-0.50876,-0.594651,0,2,partial,18.2,13.9,13.9,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); esophagus: 13.9 nTPM (protected, limit 2); thyroid gland: 13.9 nTPM (manageable, limit 5); cerebral cortex: 12.7 nTPM (vital, limit 1); skin: 12 nTPM (manageable, limit 5); heart muscle: 12 nTPM (vital, limit 1); spleen: 11.7 nTPM (manageable, limit 5); pituitary gland: 11.6 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 2); tongue: 11.1 nTPM (protected, limit 2); salivary gland: 11 nTPM (protected, limit 2); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 2); lymph node: 9.6 nTPM (protected, limit 2); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 2); duodenum: 9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 2); spinal cord: 7.3 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); midbrain: 7.2 nTPM (vital, limit 1); lung: 6.4 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 2); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104835,SARS2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 41.4634% (minimum 75%, Missing); amygdala: 60.4061% (minimum 75%, Missing); basal ganglia: 58.6207% (minimum 75%, Missing); bone marrow: 56.3981% (minimum 75%, Missing); cerebellum: 52.1930% (minimum 75%, Missing); cerebral cortex: 48.3740% (minimum 75%, Missing); choroid plexus: 60.7143% (minimum 75%, Missing); colon: 54.8387% (minimum 70%, Missing); duodenum: 56.9378% (minimum 75%, Missing); esophagus: 46.1240% (minimum 70%, Missing); heart muscle: 49.7908% (minimum 75%, Missing); hippocampal formation: 58.9109% (minimum 75%, Missing); hypothalamus: 58.6207% (minimum 75%, Missing); kidney: 45.5939% (minimum 75%, Missing); liver: 39.5349% (minimum 75%, Missing); lung: 65.0273% (minimum 75%, Missing); lymph node: 55.3488% (minimum 70%, Missing); midbrain: 62.3037% (minimum 75%, Missing); pancreas: 43.4307% (minimum 75%, Missing); parathyroid gland: 61.3402% (minimum 70%, Missing); pituitary gland: 50.6383% (minimum 75%, Missing); salivary gland: 51.9651% (minimum 70%, Missing); skeletal muscle: 42.8058% (minimum 75%, Missing); skin: 49.7908% (minimum 65%, Missing); small intestine: 54.5872% (minimum 75%, Missing); smooth muscle: 70.4142% (minimum 75%, Missing); spinal cord: 61.9792% (minimum 75%, Missing); spleen: 50.4237% (minimum 65%, Missing); stomach: 50.6383% (minimum 70%, Missing); thymus: 61.9792% (minimum 65%, Missing); thyroid gland: 46.1240% (minimum 65%, Missing); tongue: 51.7391% (minimum 70%, Missing); urinary bladder: 56.6667% (minimum 70%, Missing)",-0.18876,-0.23876,-0.354651,0,2,partial,18.2,13.9,13.9,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); esophagus: 13.9 nTPM (protected, limit 2); thyroid gland: 13.9 nTPM (manageable, limit 5); cerebral cortex: 12.7 nTPM (vital, limit 1); skin: 12 nTPM (manageable, limit 5); heart muscle: 12 nTPM (vital, limit 1); spleen: 11.7 nTPM (manageable, limit 5); pituitary gland: 11.6 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 2); tongue: 11.1 nTPM (protected, limit 2); salivary gland: 11 nTPM (protected, limit 2); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 2); lymph node: 9.6 nTPM (protected, limit 2); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 2); duodenum: 9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 2); spinal cord: 7.3 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); midbrain: 7.2 nTPM (vital, limit 1); lung: 6.4 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 2); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104835,SARS2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 41.4634% (minimum 75%, Missing); amygdala: 60.4061% (minimum 75%, Missing); basal ganglia: 58.6207% (minimum 75%, Missing); bone marrow: 56.3981% (minimum 75%, Missing); cerebellum: 52.1930% (minimum 75%, Missing); cerebral cortex: 48.3740% (minimum 75%, Missing); choroid plexus: 60.7143% (minimum 75%, Missing); colon: 54.8387% (minimum 70%, Missing); duodenum: 56.9378% (minimum 75%, Missing); esophagus: 46.1240% (minimum 70%, Missing); heart muscle: 49.7908% (minimum 75%, Missing); hippocampal formation: 58.9109% (minimum 75%, Missing); hypothalamus: 58.6207% (minimum 75%, Missing); kidney: 45.5939% (minimum 75%, Missing); liver: 39.5349% (minimum 75%, Missing); lung: 65.0273% (minimum 75%, Missing); lymph node: 55.3488% (minimum 70%, Missing); midbrain: 62.3037% (minimum 75%, Missing); pancreas: 43.4307% (minimum 75%, Missing); parathyroid gland: 61.3402% (minimum 70%, Missing); pituitary gland: 50.6383% (minimum 75%, Missing); salivary gland: 51.9651% (minimum 70%, Missing); skeletal muscle: 42.8058% (minimum 75%, Missing); skin: 49.7908% (minimum 65%, Missing); small intestine: 54.5872% (minimum 75%, Missing); smooth muscle: 70.4142% (minimum 75%, Missing); spinal cord: 61.9792% (minimum 75%, Missing); spleen: 50.4237% (minimum 65%, Missing); stomach: 50.6383% (minimum 70%, Missing); thymus: 61.9792% (minimum 65%, Missing); thyroid gland: 46.1240% (minimum 65%, Missing); tongue: 51.7391% (minimum 70%, Missing); urinary bladder: 56.6667% (minimum 70%, Missing)",-0.18876,-0.23876,-0.354651,0,2,partial,18.2,13.9,13.9,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); esophagus: 13.9 nTPM (protected, limit 3); thyroid gland: 13.9 nTPM (manageable, limit 5); cerebral cortex: 12.7 nTPM (vital, limit 1); skin: 12 nTPM (manageable, limit 5); heart muscle: 12 nTPM (vital, limit 1); spleen: 11.7 nTPM (manageable, limit 5); pituitary gland: 11.6 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 3); tongue: 11.1 nTPM (protected, limit 3); salivary gland: 11 nTPM (protected, limit 3); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 3); lymph node: 9.6 nTPM (protected, limit 3); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 3); duodenum: 9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 3); spinal cord: 7.3 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); midbrain: 7.2 nTPM (vital, limit 1); lung: 6.4 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 3); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104835,SARS2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 41.4634% (minimum 75%, Missing); amygdala: 60.4061% (minimum 75%, Missing); basal ganglia: 58.6207% (minimum 75%, Missing); bone marrow: 56.3981% (minimum 75%, Missing); cerebellum: 52.1930% (minimum 75%, Missing); cerebral cortex: 48.3740% (minimum 75%, Missing); choroid plexus: 60.7143% (minimum 75%, Missing); colon: 54.8387% (minimum 70%, Missing); duodenum: 56.9378% (minimum 75%, Missing); esophagus: 46.1240% (minimum 70%, Missing); heart muscle: 49.7908% (minimum 75%, Missing); hippocampal formation: 58.9109% (minimum 75%, Missing); hypothalamus: 58.6207% (minimum 75%, Missing); kidney: 45.5939% (minimum 75%, Missing); liver: 39.5349% (minimum 75%, Missing); lung: 65.0273% (minimum 75%, Missing); lymph node: 55.3488% (minimum 70%, Missing); midbrain: 62.3037% (minimum 75%, Missing); pancreas: 43.4307% (minimum 75%, Missing); parathyroid gland: 61.3402% (minimum 70%, Missing); pituitary gland: 50.6383% (minimum 75%, Missing); salivary gland: 51.9651% (minimum 70%, Missing); skeletal muscle: 42.8058% (minimum 75%, Missing); skin: 49.7908% (minimum 65%, Missing); small intestine: 54.5872% (minimum 75%, Missing); smooth muscle: 70.4142% (minimum 75%, Missing); spinal cord: 61.9792% (minimum 75%, Missing); spleen: 50.4237% (minimum 65%, Missing); stomach: 50.6383% (minimum 70%, Missing); thymus: 61.9792% (minimum 65%, Missing); thyroid gland: 46.1240% (minimum 65%, Missing); tongue: 51.7391% (minimum 70%, Missing); urinary bladder: 56.6667% (minimum 70%, Missing)",-0.18876,-0.23876,-0.354651,0,2,partial,18.2,13.9,13.9,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); esophagus: 13.9 nTPM (protected, limit 3); thyroid gland: 13.9 nTPM (manageable, limit 5); cerebral cortex: 12.7 nTPM (vital, limit 1); skin: 12 nTPM (manageable, limit 5); heart muscle: 12 nTPM (vital, limit 1); spleen: 11.7 nTPM (manageable, limit 5); pituitary gland: 11.6 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 3); tongue: 11.1 nTPM (protected, limit 3); salivary gland: 11 nTPM (protected, limit 3); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 3); lymph node: 9.6 nTPM (protected, limit 3); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 3); duodenum: 9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 3); spinal cord: 7.3 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); midbrain: 7.2 nTPM (vital, limit 1); lung: 6.4 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 3); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104835,SARS2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6316% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 41.4634% (minimum 75%, Baseline (adaptation disabled)); amygdala: 60.4061% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.6207% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 56.3981% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 52.1930% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.3740% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.7143% (minimum 75%, Baseline (adaptation disabled)); colon: 54.8387% (minimum 70%, Baseline (adaptation disabled)); duodenum: 56.9378% (minimum 75%, Baseline (adaptation disabled)); esophagus: 46.1240% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 49.7908% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.9109% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.6207% (minimum 75%, Baseline (adaptation disabled)); kidney: 45.5939% (minimum 75%, Baseline (adaptation disabled)); liver: 39.5349% (minimum 75%, Baseline (adaptation disabled)); lung: 65.0273% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.3488% (minimum 70%, Baseline (adaptation disabled)); midbrain: 62.3037% (minimum 75%, Baseline (adaptation disabled)); pancreas: 43.4307% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.3402% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 50.6383% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.9651% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 42.8058% (minimum 75%, Baseline (adaptation disabled)); skin: 49.7908% (minimum 65%, Baseline (adaptation disabled)); small intestine: 54.5872% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.4142% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.9792% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.4237% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.6383% (minimum 70%, Baseline (adaptation disabled)); thymus: 61.9792% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 46.1240% (minimum 65%, Baseline (adaptation disabled)); tongue: 51.7391% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.6667% (minimum 70%, Baseline (adaptation disabled))",-0.18876,-0.23876,-0.354651,0,2,partial,18.2,13.9,13.9,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); thyroid gland: 13.9 nTPM (manageable, limit 5); esophagus: 13.9 nTPM (protected, limit 3); cerebral cortex: 12.7 nTPM (vital, limit 1); skin: 12 nTPM (manageable, limit 5); heart muscle: 12 nTPM (vital, limit 1); spleen: 11.7 nTPM (manageable, limit 5); pituitary gland: 11.6 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 3); tongue: 11.1 nTPM (protected, limit 3); salivary gland: 11 nTPM (protected, limit 3); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 3); lymph node: 9.6 nTPM (protected, limit 3); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 3); duodenum: 9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 3); thymus: 7.3 nTPM (manageable, limit 5); spinal cord: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 3); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104835,SARS2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.2199% (minimum 90%, Approved); adrenal gland: 51.2658% (minimum 99%, Missing); amygdala: 59.7786% (minimum 99%, Missing); basal ganglia: 57.4468% (minimum 99%, Missing); bone marrow: 37.6744% (minimum 99%, Missing); cerebellum: 52.5974% (minimum 98%, Approved); cerebral cortex: 51.4286% (minimum 98%, Approved); choroid plexus: 79.0244% (minimum 99%, Missing); colon: 42.9708% (minimum 97%, Missing); duodenum: 55.4795% (minimum 99%, Missing); esophagus: 45.6338% (minimum 97%, Missing); heart muscle: 70.1299% (minimum 99%, Missing); hippocampal formation: 56.0554% (minimum 99%, Missing); hypothalamus: 61.5970% (minimum 99%, Missing); kidney: 40.9091% (minimum 99%, Missing); liver: 56.0554% (minimum 98%, Approved); lung: 53.4653% (minimum 99%, Missing); lymph node: 35.8407% (minimum 97%, Missing); midbrain: 58.6957% (minimum 99%, Missing); pancreas: 44.2623% (minimum 99%, Missing); parathyroid gland: 60.0000% (minimum 95%, Approved); pituitary gland: 51.2658% (minimum 99%, Missing); rectum: 68.3544% (minimum 97%, Missing); retina: 77.1429% (minimum 99%, Missing); salivary gland: 60.4478% (minimum 97%, Missing); skeletal muscle: 76.0563% (minimum 99%, Missing); skin: 54.9153% (minimum 95%, Missing); small intestine: 34.8387% (minimum 99%, Missing); smooth muscle: 54.7297% (minimum 98%, Approved); spinal cord: 57.8571% (minimum 99%, Missing); spleen: 31.5789% (minimum 95%, Missing); stomach: 42.5197% (minimum 97%, Missing); thymus: 33.4711% (minimum 95%, Missing); thyroid gland: 60.6742% (minimum 95%, Missing); tongue: 85.2632% (minimum 97%, Missing); urinary bladder: 54.5455% (minimum 97%, Missing)",-0.634211,-0.611593,-0.641613,0,5,partial,30.3,29,35.1,"spleen: 35.1 nTPM (manageable, limit 5); thymus: 32.2 nTPM (manageable, limit 5); small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 2); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 2); colon: 21.5 nTPM (protected, limit 2); pancreas: 20.4 nTPM (vital, limit 1); esophagus: 19.3 nTPM (protected, limit 2); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 2); cerebellum: 14.6 nTPM (vital, limit 2); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 2); smooth muscle: 13.4 nTPM (vital, limit 2); skin: 13.3 nTPM (manageable, limit 5); duodenum: 13 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 4); salivary gland: 10.6 nTPM (protected, limit 2); thyroid gland: 10.5 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); rectum: 7.5 nTPM (protected, limit 2); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104880,ARHGEF18,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 51.2658% (minimum 75%, Missing); amygdala: 59.7786% (minimum 75%, Missing); basal ganglia: 57.4468% (minimum 75%, Missing); bone marrow: 37.6744% (minimum 75%, Missing); cerebellum: 52.5974% (minimum 70%, Approved); cerebral cortex: 51.4286% (minimum 70%, Approved); colon: 42.9708% (minimum 70%, Missing); duodenum: 55.4795% (minimum 75%, Missing); esophagus: 45.6338% (minimum 70%, Missing); heart muscle: 70.1299% (minimum 75%, Missing); hippocampal formation: 56.0554% (minimum 75%, Missing); hypothalamus: 61.5970% (minimum 75%, Missing); kidney: 40.9091% (minimum 75%, Missing); liver: 56.0554% (minimum 70%, Approved); lung: 53.4653% (minimum 75%, Missing); lymph node: 35.8407% (minimum 70%, Missing); midbrain: 58.6957% (minimum 75%, Missing); pancreas: 44.2623% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 65%, Approved); pituitary gland: 51.2658% (minimum 75%, Missing); rectum: 68.3544% (minimum 70%, Missing); salivary gland: 60.4478% (minimum 70%, Missing); skin: 54.9153% (minimum 65%, Missing); small intestine: 34.8387% (minimum 75%, Missing); smooth muscle: 54.7297% (minimum 70%, Approved); spinal cord: 57.8571% (minimum 75%, Missing); spleen: 31.5789% (minimum 65%, Missing); stomach: 42.5197% (minimum 70%, Missing); thymus: 33.4711% (minimum 65%, Missing); thyroid gland: 60.6742% (minimum 65%, Missing); urinary bladder: 54.5455% (minimum 70%, Missing)",-0.334211,-0.341593,-0.401613,0,5,partial,30.3,29,35.1,"spleen: 35.1 nTPM (manageable, limit 5); thymus: 32.2 nTPM (manageable, limit 5); small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 2); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 2); colon: 21.5 nTPM (protected, limit 2); pancreas: 20.4 nTPM (vital, limit 1); esophagus: 19.3 nTPM (protected, limit 2); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 2); cerebellum: 14.6 nTPM (vital, limit 2); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 2); smooth muscle: 13.4 nTPM (vital, limit 2); skin: 13.3 nTPM (manageable, limit 5); duodenum: 13 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 4); salivary gland: 10.6 nTPM (protected, limit 2); thyroid gland: 10.5 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); rectum: 7.5 nTPM (protected, limit 2); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104880,ARHGEF18,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 51.2658% (minimum 75%, Missing); amygdala: 59.7786% (minimum 75%, Missing); basal ganglia: 57.4468% (minimum 75%, Missing); bone marrow: 37.6744% (minimum 75%, Missing); cerebellum: 52.5974% (minimum 70%, Approved); cerebral cortex: 51.4286% (minimum 70%, Approved); colon: 42.9708% (minimum 70%, Missing); duodenum: 55.4795% (minimum 75%, Missing); esophagus: 45.6338% (minimum 70%, Missing); heart muscle: 70.1299% (minimum 75%, Missing); hippocampal formation: 56.0554% (minimum 75%, Missing); hypothalamus: 61.5970% (minimum 75%, Missing); kidney: 40.9091% (minimum 75%, Missing); liver: 56.0554% (minimum 70%, Approved); lung: 53.4653% (minimum 75%, Missing); lymph node: 35.8407% (minimum 70%, Missing); midbrain: 58.6957% (minimum 75%, Missing); pancreas: 44.2623% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 65%, Approved); pituitary gland: 51.2658% (minimum 75%, Missing); rectum: 68.3544% (minimum 70%, Missing); salivary gland: 60.4478% (minimum 70%, Missing); skin: 54.9153% (minimum 65%, Missing); small intestine: 34.8387% (minimum 75%, Missing); smooth muscle: 54.7297% (minimum 70%, Approved); spinal cord: 57.8571% (minimum 75%, Missing); spleen: 31.5789% (minimum 65%, Missing); stomach: 42.5197% (minimum 70%, Missing); thymus: 33.4711% (minimum 65%, Missing); thyroid gland: 60.6742% (minimum 65%, Missing); urinary bladder: 54.5455% (minimum 70%, Missing)",-0.334211,-0.341593,-0.401613,0,5,partial,30.3,29,35.1,"spleen: 35.1 nTPM (manageable, limit 5); thymus: 32.2 nTPM (manageable, limit 5); small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 3); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 3); colon: 21.5 nTPM (protected, limit 3); pancreas: 20.4 nTPM (vital, limit 1); esophagus: 19.3 nTPM (protected, limit 3); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 2); cerebellum: 14.6 nTPM (vital, limit 2); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 3); smooth muscle: 13.4 nTPM (vital, limit 2); skin: 13.3 nTPM (manageable, limit 5); duodenum: 13 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 4); salivary gland: 10.6 nTPM (protected, limit 3); thyroid gland: 10.5 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); rectum: 7.5 nTPM (protected, limit 3); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104880,ARHGEF18,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 51.2658% (minimum 75%, Missing); amygdala: 59.7786% (minimum 75%, Missing); basal ganglia: 57.4468% (minimum 75%, Missing); bone marrow: 37.6744% (minimum 75%, Missing); cerebellum: 52.5974% (minimum 70%, Approved); cerebral cortex: 51.4286% (minimum 70%, Approved); colon: 42.9708% (minimum 70%, Missing); duodenum: 55.4795% (minimum 75%, Missing); esophagus: 45.6338% (minimum 70%, Missing); heart muscle: 70.1299% (minimum 75%, Missing); hippocampal formation: 56.0554% (minimum 75%, Missing); hypothalamus: 61.5970% (minimum 75%, Missing); kidney: 40.9091% (minimum 75%, Missing); liver: 56.0554% (minimum 70%, Approved); lung: 53.4653% (minimum 75%, Missing); lymph node: 35.8407% (minimum 70%, Missing); midbrain: 58.6957% (minimum 75%, Missing); pancreas: 44.2623% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 65%, Approved); pituitary gland: 51.2658% (minimum 75%, Missing); rectum: 68.3544% (minimum 70%, Missing); salivary gland: 60.4478% (minimum 70%, Missing); skin: 54.9153% (minimum 65%, Missing); small intestine: 34.8387% (minimum 75%, Missing); smooth muscle: 54.7297% (minimum 70%, Approved); spinal cord: 57.8571% (minimum 75%, Missing); spleen: 31.5789% (minimum 65%, Missing); stomach: 42.5197% (minimum 70%, Missing); thymus: 33.4711% (minimum 65%, Missing); thyroid gland: 60.6742% (minimum 65%, Missing); urinary bladder: 54.5455% (minimum 70%, Missing)",-0.334211,-0.341593,-0.401613,0,5,partial,30.3,29,35.1,"spleen: 35.1 nTPM (manageable, limit 5); thymus: 32.2 nTPM (manageable, limit 5); small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 3); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 3); colon: 21.5 nTPM (protected, limit 3); pancreas: 20.4 nTPM (vital, limit 1); esophagus: 19.3 nTPM (protected, limit 3); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 2); cerebellum: 14.6 nTPM (vital, limit 2); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 3); smooth muscle: 13.4 nTPM (vital, limit 2); skin: 13.3 nTPM (manageable, limit 5); duodenum: 13 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 4); salivary gland: 10.6 nTPM (protected, limit 3); thyroid gland: 10.5 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); rectum: 7.5 nTPM (protected, limit 3); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104880,ARHGEF18,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 51.2658% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.7786% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 57.4468% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 37.6744% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 52.5974% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.4286% (minimum 75%, Baseline (adaptation disabled)); colon: 42.9708% (minimum 70%, Baseline (adaptation disabled)); duodenum: 55.4795% (minimum 75%, Baseline (adaptation disabled)); esophagus: 45.6338% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.1299% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 56.0554% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.5970% (minimum 75%, Baseline (adaptation disabled)); kidney: 40.9091% (minimum 75%, Baseline (adaptation disabled)); liver: 56.0554% (minimum 75%, Baseline (adaptation disabled)); lung: 53.4653% (minimum 75%, Baseline (adaptation disabled)); lymph node: 35.8407% (minimum 70%, Baseline (adaptation disabled)); midbrain: 58.6957% (minimum 75%, Baseline (adaptation disabled)); pancreas: 44.2623% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 51.2658% (minimum 75%, Baseline (adaptation disabled)); rectum: 68.3544% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 60.4478% (minimum 70%, Baseline (adaptation disabled)); skin: 54.9153% (minimum 65%, Baseline (adaptation disabled)); small intestine: 34.8387% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 54.7297% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.8571% (minimum 75%, Baseline (adaptation disabled)); spleen: 31.5789% (minimum 65%, Baseline (adaptation disabled)); stomach: 42.5197% (minimum 70%, Baseline (adaptation disabled)); thymus: 33.4711% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 60.6742% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 54.5455% (minimum 70%, Baseline (adaptation disabled))",-0.334211,-0.341593,-0.401613,0,5,partial,30.3,29,35.1,"spleen: 35.1 nTPM (manageable, limit 5); thymus: 32.2 nTPM (manageable, limit 5); small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 3); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 3); colon: 21.5 nTPM (protected, limit 3); pancreas: 20.4 nTPM (vital, limit 1); esophagus: 19.3 nTPM (protected, limit 3); pituitary gland: 15.4 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 3); smooth muscle: 13.4 nTPM (vital, limit 1); skin: 13.3 nTPM (manageable, limit 5); duodenum: 13 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 3); salivary gland: 10.6 nTPM (protected, limit 3); thyroid gland: 10.5 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); adipose tissue: 7.9 nTPM (manageable, limit 5); rectum: 7.5 nTPM (protected, limit 3); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104880,ARHGEF18,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.0291058,0.00910581,0,1,partial,0.9,0.9,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104901,DKKL1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299106,0.249106,0,1,partial,0.9,0.9,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104901,DKKL1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299106,0.249106,0,1,partial,0.9,0.9,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104901,DKKL1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299106,0.249106,0,1,partial,0.9,0.9,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104901,DKKL1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347916,0.297322,0.247322,0,1,partial,0.9,0.9,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104901,DKKL1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,2.7,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104941,RSPH6A,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,2.7,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104941,RSPH6A,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,2.7,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104941,RSPH6A,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,2.7,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104941,RSPH6A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.264557,0.3,0.25,0,2,partial,0,0,2.7,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104941,RSPH6A,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.6543% (minimum 99%, Missing); basal ganglia: 98.1132% (minimum 99%, Missing); bone marrow: 86.6667% (minimum 99%, Missing); cerebellum: 98.8593% (minimum 99%, Missing); choroid plexus: 97.0149% (minimum 99%, Missing); colon: 94.5455% (minimum 97%, Missing); duodenum: 88.1356% (minimum 99%, Missing); hippocampal formation: 96.2963% (minimum 99%, Missing); hypothalamus: 97.7444% (minimum 99%, Missing); kidney: 84.6906% (minimum 99%, Missing); lung: 91.8728% (minimum 99%, Missing); lymph node: 74.2857% (minimum 97%, Missing); midbrain: 96.6543% (minimum 99%, Missing); pituitary gland: 98.1132% (minimum 99%, Missing); rectum: 95.2381% (minimum 97%, Missing); small intestine: 90.9091% (minimum 99%, Missing); smooth muscle: 94.8905% (minimum 95%, Enhanced); spinal cord: 94.5455% (minimum 99%, Missing); spleen: 86.9565% (minimum 95%, Missing); thymus: 89.0411% (minimum 95%, Missing)",-0.0804348,-0.227143,-0.143094,0,11,partial,4.7,9,3.9,"lymph node: 9 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / cells in spinous layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / langerhans cells: High (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 1 / sebaceous glands: High (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: High (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / langerhans cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / sebaceous glands; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104951,IL4I1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.219565,0.0428571,0.0969055,0,11,partial,4.7,9,3.9,"lymph node: 9 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / cells in spinous layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / langerhans cells: High (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 1 / sebaceous glands: High (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: High (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / langerhans cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / sebaceous glands; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104951,IL4I1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.219565,0.0428571,0.0969055,0,11,partial,4.7,9,3.9,"lymph node: 9 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / cells in spinous layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / langerhans cells: High (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 1 / sebaceous glands: High (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: High (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / langerhans cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / sebaceous glands; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104951,IL4I1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.219565,0.0428571,0.0969055,0,11,partial,4.7,9,3.9,"lymph node: 9 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / cells in spinous layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / langerhans cells: High (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 1 / sebaceous glands: High (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: High (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / langerhans cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / sebaceous glands; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104951,IL4I1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.219565,0.0428571,0.0969055,0,11,partial,4.7,9,3.9,"lymph node: 9 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / cells in spinous layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / langerhans cells: High (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 1 / sebaceous glands: High (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: High (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / langerhans cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / sebaceous glands; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000104951,IL4I1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.6923% (minimum 99%, Missing); bone marrow: 73.0047% (minimum 95%, Enhanced); cerebral cortex: 98.7302% (minimum 99%, Missing); colon: 81.2010% (minimum 97%, Missing); duodenum: 85.9116% (minimum 99%, Missing); esophagus: 75.6691% (minimum 80%, Enhanced); heart muscle: 98.1073% (minimum 99%, Missing); kidney: 96.8847% (minimum 99%, Missing); lung: 93.9577% (minimum 95%, Enhanced); lymph node: 71.8245% (minimum 97%, Missing); pancreas: 98.1073% (minimum 99%, Missing); pituitary gland: 97.7987% (minimum 99%, Missing); rectum: 80.5699% (minimum 97%, Missing); salivary gland: 94.2424% (minimum 97%, Missing); small intestine: 84.2818% (minimum 99%, Missing); smooth muscle: 94.2424% (minimum 95%, Enhanced); thymus: 57.9143% (minimum 95%, Missing); urinary bladder: 94.8171% (minimum 97%, Missing)",-0.370857,-0.251755,-0.219953,0,6,partial,11.5,12.2,22.6,"thymus: 22.6 nTPM (manageable, limit 5); lymph node: 12.2 nTPM (protected, limit 2); bone marrow: 11.5 nTPM (vital, limit 6); rectum: 7.5 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105011,ASF1B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 57.9143% (minimum 65%, Missing)",-0.0708566,0.0182448,0.0928184,0,6,partial,11.5,12.2,22.6,"thymus: 22.6 nTPM (manageable, limit 5); lymph node: 12.2 nTPM (protected, limit 2); bone marrow: 11.5 nTPM (vital, limit 6); rectum: 7.5 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105011,ASF1B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 57.9143% (minimum 65%, Missing)",-0.0708566,0.0182448,0.0928184,0,6,partial,11.5,12.2,22.6,"thymus: 22.6 nTPM (manageable, limit 5); lymph node: 12.2 nTPM (protected, limit 3); bone marrow: 11.5 nTPM (vital, limit 6); rectum: 7.5 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105011,ASF1B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 57.9143% (minimum 65%, Missing)",-0.0708566,0.0182448,0.0928184,0,6,partial,11.5,12.2,22.6,"thymus: 22.6 nTPM (manageable, limit 5); lymph node: 12.2 nTPM (protected, limit 3); bone marrow: 11.5 nTPM (vital, limit 6); rectum: 7.5 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105011,ASF1B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 73.0047% (minimum 75%, Baseline (adaptation disabled)); thymus: 57.9143% (minimum 65%, Baseline (adaptation disabled))",-0.0708566,0.0182448,-0.0199531,0,6,partial,11.5,12.2,22.6,"thymus: 22.6 nTPM (manageable, limit 5); lymph node: 12.2 nTPM (protected, limit 3); bone marrow: 11.5 nTPM (vital, limit 1); esophagus: 10 nTPM (protected, limit 3); rectum: 7.5 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); spleen: 6.6 nTPM (manageable, limit 5); small intestine: 5.8 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); lung: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105011,ASF1B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.6494% (minimum 95%, Enhanced); amygdala: 92.3280% (minimum 99%, Missing); basal ganglia: 92.0844% (minimum 99%, Missing); bone marrow: 76.2009% (minimum 95%, Enhanced); cerebellum: 88.8041% (minimum 95%, Enhanced); cerebral cortex: 92.3280% (minimum 95%, Enhanced); choroid plexus: 92.0844% (minimum 99%, Missing); colon: 89.9485% (minimum 97%, Missing); duodenum: 93.8172% (minimum 95%, Enhanced); heart muscle: 91.8421% (minimum 95%, Enhanced); hippocampal formation: 92.3280% (minimum 99%, Missing); hypothalamus: 91.8421% (minimum 99%, Missing); kidney: 92.8191% (minimum 95%, Enhanced); liver: 90.6494% (minimum 95%, Enhanced); lung: 89.9485% (minimum 95%, Enhanced); midbrain: 93.3155% (minimum 99%, Missing); pancreas: 90.1809% (minimum 95%, Enhanced); pituitary gland: 90.8854% (minimum 99%, Missing); retina: 94.5799% (minimum 99%, Missing); skeletal muscle: 83.8942% (minimum 95%, Enhanced); small intestine: 90.8854% (minimum 95%, Enhanced); smooth muscle: 93.5657% (minimum 95%, Enhanced); spinal cord: 91.3613% (minimum 99%, Missing); thymus: 89.0306% (minimum 95%, Missing); tongue: 91.8421% (minimum 97%, Missing)",-0.0596939,-0.0705155,-0.187991,0,8,partial,10.9,5.1,6.2,"bone marrow: 10.9 nTPM (vital, limit 6); skeletal muscle: 6.7 nTPM (vital, limit 6); colon: 3.9 nTPM (protected, limit 2); pituitary gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105085,MED26,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.240306,0.199485,0.158854,0,8,partial,10.9,5.1,6.2,"bone marrow: 10.9 nTPM (vital, limit 6); skeletal muscle: 6.7 nTPM (vital, limit 6); colon: 3.9 nTPM (protected, limit 2); pituitary gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105085,MED26,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.240306,0.199485,0.158854,0,8,partial,10.9,5.1,6.2,"bone marrow: 10.9 nTPM (vital, limit 6); skeletal muscle: 6.7 nTPM (vital, limit 6); colon: 3.9 nTPM (protected, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105085,MED26,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.240306,0.199485,0.158854,0,8,partial,10.9,5.1,6.2,"bone marrow: 10.9 nTPM (vital, limit 6); skeletal muscle: 6.7 nTPM (vital, limit 6); colon: 3.9 nTPM (protected, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105085,MED26,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.199148,0.1725,0.0120087,0,8,partial,10.9,5.1,6.2,"bone marrow: 10.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 3); lymph node: 4.7 nTPM (protected, limit 3); cerebellum: 4.4 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 3); pancreas: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); small intestine: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105085,MED26,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 77.9370% (minimum 99%, Missing); basal ganglia: 55.5102% (minimum 99%, Missing); cerebellum: 18.8496% (minimum 99%, Missing); cerebral cortex: 70.2842% (minimum 99%, Missing); choroid plexus: 98.1949% (minimum 99%, Missing); hippocampal formation: 69.3878% (minimum 99%, Missing); hypothalamus: 72.9223% (minimum 99%, Missing); midbrain: 89.4737% (minimum 99%, Missing); pituitary gland: 98.9091% (minimum 99%, Missing); retina: 92.5170% (minimum 99%, Missing); skeletal muscle: 98.9091% (minimum 99%, Missing); skin: 76.6197% (minimum 95%, Missing); spinal cord: 89.1803% (minimum 99%, Missing)",-0.183803,0.0227007,-0.801504,0,11,partial,117.1,0.9,8.3,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / endothelial cells: High (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105143,SLC1A6,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 55.5102% (minimum 75%, Missing); cerebellum: 18.8496% (minimum 75%, Missing); cerebral cortex: 70.2842% (minimum 75%, Missing); hippocampal formation: 69.3878% (minimum 75%, Missing); hypothalamus: 72.9223% (minimum 75%, Missing)",0.116197,0.292701,-0.561504,0,11,partial,117.1,0.9,8.3,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / endothelial cells: High (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105143,SLC1A6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 55.5102% (minimum 75%, Missing); cerebellum: 18.8496% (minimum 75%, Missing); cerebral cortex: 70.2842% (minimum 75%, Missing); hippocampal formation: 69.3878% (minimum 75%, Missing); hypothalamus: 72.9223% (minimum 75%, Missing)",0.116197,0.292701,-0.561504,0,11,partial,117.1,0.9,8.3,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / endothelial cells: High (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105143,SLC1A6,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 55.5102% (minimum 75%, Missing); cerebellum: 18.8496% (minimum 75%, Missing); cerebral cortex: 70.2842% (minimum 75%, Missing); hippocampal formation: 69.3878% (minimum 75%, Missing); hypothalamus: 72.9223% (minimum 75%, Missing)",0.116197,0.292701,-0.561504,0,11,partial,117.1,0.9,8.3,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / endothelial cells: High (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105143,SLC1A6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 55.5102% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 18.8496% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.2842% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 69.3878% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.9223% (minimum 75%, Baseline (adaptation disabled))",0.116197,0.267972,-0.561504,0,11,partial,117.1,0.9,8.3,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / endothelial cells: High (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105143,SLC1A6,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8355% (minimum 99%, Missing); amygdala: 96.9957% (minimum 99%, Missing); basal ganglia: 96.9957% (minimum 99%, Missing); bone marrow: 96.9957% (minimum 99%, Missing); cerebellum: 97.6242% (minimum 99%, Missing); cerebral cortex: 94.7589% (minimum 99%, Missing); choroid plexus: 92.6230% (minimum 99%, Missing); heart muscle: 96.1702% (minimum 99%, Missing); hippocampal formation: 96.7880% (minimum 99%, Missing); hypothalamus: 96.1702% (minimum 99%, Missing); kidney: 96.9957% (minimum 99%, Missing); liver: 94.5607% (minimum 99%, Missing); lung: 98.0477% (minimum 99%, Missing); lymph node: 93.0041% (minimum 97%, Missing); midbrain: 95.7627% (minimum 99%, Missing); pancreas: 98.0477% (minimum 99%, Missing); pituitary gland: 97.4138% (minimum 99%, Missing); retina: 97.6242% (minimum 99%, Missing); skeletal muscle: 96.3753% (minimum 99%, Missing); small intestine: 98.4749% (minimum 99%, Missing); smooth muscle: 97.6242% (minimum 99%, Missing); spinal cord: 93.1959% (minimum 99%, Missing); spleen: 90.2196% (minimum 95%, Missing)",-0.0478044,-0.0399588,-0.0637705,0,80,unavailable,3.6,3.4,4.9,"choroid plexus: 3.6 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105146,AURKC,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.252196,0.230041,0.17623,0,80,unavailable,3.6,3.4,4.9,"choroid plexus: 3.6 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105146,AURKC,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.252196,0.230041,0.17623,0,80,unavailable,3.6,3.4,4.9,"choroid plexus: 3.6 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105146,AURKC,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.252196,0.230041,0.17623,0,80,unavailable,3.6,3.4,4.9,"choroid plexus: 3.6 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105146,AURKC,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.252196,0.230041,0.17623,0,80,unavailable,3.6,3.4,4.9,"choroid plexus: 3.6 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105146,AURKC,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.1982% (minimum 99%, Missing)",0.05,0.0209091,-0.00801802,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105198,LGALS13,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.290909,0.231982,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105198,LGALS13,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.290909,0.231982,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105198,LGALS13,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.290909,0.231982,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105198,LGALS13,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.290909,0.231982,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105198,LGALS13,current_fixed,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.0756% (minimum 99%, Missing); basal ganglia: 98.6860% (minimum 99%, Missing); choroid plexus: 97.0088% (minimum 99%, Missing); hippocampal formation: 98.2782% (minimum 99%, Missing); hypothalamus: 98.4817% (minimum 99%, Missing); midbrain: 97.4061% (minimum 99%, Missing); pituitary gland: 98.8227% (minimum 99%, Missing); small intestine: 94.6286% (minimum 95%, Enhanced); spinal cord: 96.6148% (minimum 99%, Missing); thymus: 93.9434% (minimum 95%, Missing)",-0.0105662,0.0272048,-0.0238524,0,3,partial,8.1,19.7,33.1,"spleen: 33.1 nTPM (manageable, limit 30); lymph node: 19.7 nTPM (protected, limit 12); thymus: 9.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105246,EBI3,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.289434,0.297205,0.216148,0,3,partial,8.1,19.7,33.1,"spleen: 33.1 nTPM (manageable, limit 30); lymph node: 19.7 nTPM (protected, limit 12); thymus: 9.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105246,EBI3,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.289434,0.297205,0.216148,0,3,partial,8.1,19.7,33.1,"spleen: 33.1 nTPM (manageable, limit 30); lymph node: 19.7 nTPM (protected, limit 12); thymus: 9.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105246,EBI3,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.289434,0.297205,0.216148,0,3,partial,8.1,19.7,33.1,"spleen: 33.1 nTPM (manageable, limit 30); lymph node: 19.7 nTPM (protected, limit 12); thymus: 9.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105246,EBI3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.161718,0.178695,0.196286,0,3,partial,8.1,19.7,33.1,"spleen: 33.1 nTPM (manageable, limit 5); lymph node: 19.7 nTPM (protected, limit 3); thymus: 9.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 3); adrenal gland: 4.5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); liver: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105246,EBI3,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.3684% (minimum 99%, Missing); cerebellum: 97.3684% (minimum 99%, Missing); pituitary gland: 92.5000% (minimum 99%, Missing); retina: 94.8718% (minimum 99%, Missing); skeletal muscle: 94.8718% (minimum 99%, Missing); skin: 82.2222% (minimum 95%, Missing)",-0.127778,0.00368421,-0.065,0,80,unavailable,0.3,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105261,OVOL3,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.172222,0.273684,0.175,0,80,unavailable,0.3,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105261,OVOL3,selectivity_revised,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.172222,0.273684,0.175,0,80,unavailable,0.3,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105261,OVOL3,grid_revised,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.172222,0.273684,0.175,0,80,unavailable,0.3,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105261,OVOL3,current_adaptive,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.172222,0.273684,0.175,0,80,unavailable,0.3,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105261,OVOL3,current_fixed,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.2005% (minimum 95%, Missing); adrenal gland: 83.0091% (minimum 99%, Missing); amygdala: 29.6984% (minimum 99%, Missing); basal ganglia: 32.5203% (minimum 99%, Missing); cerebellum: 22.9308% (minimum 99%, Missing); cerebral cortex: 23.0299% (minimum 99%, Missing); choroid plexus: 68.3031% (minimum 99%, Missing); colon: 46.8178% (minimum 97%, Missing); duodenum: 91.0384% (minimum 99%, Missing); esophagus: 80.3011% (minimum 97%, Missing); heart muscle: 83.8794% (minimum 99%, Missing); hippocampal formation: 31.6362% (minimum 99%, Missing); hypothalamus: 29.9625% (minimum 99%, Missing); kidney: 85.1064% (minimum 99%, Missing); liver: 95.8084% (minimum 99%, Missing); lung: 86.8385% (minimum 99%, Missing); lymph node: 90.3955% (minimum 97%, Missing); midbrain: 35.1455% (minimum 99%, Missing); pancreas: 94.8148% (minimum 99%, Missing); parathyroid gland: 96.2406% (minimum 97%, Missing); pituitary gland: 58.3409% (minimum 99%, Missing); rectum: 88.5201% (minimum 97%, Missing); retina: 54.6075% (minimum 99%, Missing); salivary gland: 91.2981% (minimum 97%, Missing); skeletal muscle: 95.2381% (minimum 99%, Missing); skin: 89.3855% (minimum 95%, Missing); small intestine: 75.4717% (minimum 99%, Missing); smooth muscle: 63.6183% (minimum 99%, Missing); spinal cord: 41.5584% (minimum 99%, Missing); spleen: 86.8385% (minimum 95%, Missing); stomach: 72.0721% (minimum 97%, Missing); thymus: 87.4317% (minimum 95%, Missing); thyroid gland: 92.2190% (minimum 95%, Missing); tongue: 94.9555% (minimum 97%, Missing); urinary bladder: 49.2308% (minimum 97%, Missing)",-0.147995,-0.501822,-0.760692,0,80,unavailable,215.1,72.7,15.8,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 2); urinary bladder: 66 nTPM (protected, limit 2); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 2); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (manageable, limit 5); esophagus: 15.7 nTPM (protected, limit 2); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); spleen: 9.7 nTPM (manageable, limit 5); lung: 9.7 nTPM (vital, limit 1); thymus: 9.2 nTPM (manageable, limit 5); rectum: 8.3 nTPM (protected, limit 2); skin: 7.6 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); thyroid gland: 5.4 nTPM (manageable, limit 5); pancreas: 3.5 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105270,CLIP3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 29.6984% (minimum 75%, Missing); basal ganglia: 32.5203% (minimum 75%, Missing); cerebellum: 22.9308% (minimum 75%, Missing); cerebral cortex: 23.0299% (minimum 75%, Missing); choroid plexus: 68.3031% (minimum 75%, Missing); colon: 46.8178% (minimum 70%, Missing); hippocampal formation: 31.6362% (minimum 75%, Missing); hypothalamus: 29.9625% (minimum 75%, Missing); midbrain: 35.1455% (minimum 75%, Missing); pituitary gland: 58.3409% (minimum 75%, Missing); retina: 54.6075% (minimum 75%, Missing); smooth muscle: 63.6183% (minimum 75%, Missing); spinal cord: 41.5584% (minimum 75%, Missing); urinary bladder: 49.2308% (minimum 70%, Missing)",0.152005,-0.231822,-0.520692,0,80,unavailable,215.1,72.7,15.8,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 2); urinary bladder: 66 nTPM (protected, limit 2); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 2); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (manageable, limit 5); esophagus: 15.7 nTPM (protected, limit 2); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); spleen: 9.7 nTPM (manageable, limit 5); lung: 9.7 nTPM (vital, limit 1); thymus: 9.2 nTPM (manageable, limit 5); rectum: 8.3 nTPM (protected, limit 2); skin: 7.6 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); thyroid gland: 5.4 nTPM (manageable, limit 5); pancreas: 3.5 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105270,CLIP3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 29.6984% (minimum 75%, Missing); basal ganglia: 32.5203% (minimum 75%, Missing); cerebellum: 22.9308% (minimum 75%, Missing); cerebral cortex: 23.0299% (minimum 75%, Missing); choroid plexus: 68.3031% (minimum 75%, Missing); colon: 46.8178% (minimum 70%, Missing); hippocampal formation: 31.6362% (minimum 75%, Missing); hypothalamus: 29.9625% (minimum 75%, Missing); midbrain: 35.1455% (minimum 75%, Missing); pituitary gland: 58.3409% (minimum 75%, Missing); retina: 54.6075% (minimum 75%, Missing); smooth muscle: 63.6183% (minimum 75%, Missing); spinal cord: 41.5584% (minimum 75%, Missing); urinary bladder: 49.2308% (minimum 70%, Missing)",0.152005,-0.231822,-0.520692,0,80,unavailable,215.1,72.7,15.8,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 3); urinary bladder: 66 nTPM (protected, limit 3); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 3); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (manageable, limit 5); esophagus: 15.7 nTPM (protected, limit 3); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); spleen: 9.7 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); rectum: 8.3 nTPM (protected, limit 3); skin: 7.6 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); thyroid gland: 5.4 nTPM (manageable, limit 5); pancreas: 3.5 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105270,CLIP3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 29.6984% (minimum 75%, Missing); basal ganglia: 32.5203% (minimum 75%, Missing); cerebellum: 22.9308% (minimum 75%, Missing); cerebral cortex: 23.0299% (minimum 75%, Missing); choroid plexus: 68.3031% (minimum 75%, Missing); colon: 46.8178% (minimum 70%, Missing); hippocampal formation: 31.6362% (minimum 75%, Missing); hypothalamus: 29.9625% (minimum 75%, Missing); midbrain: 35.1455% (minimum 75%, Missing); pituitary gland: 58.3409% (minimum 75%, Missing); retina: 54.6075% (minimum 75%, Missing); smooth muscle: 63.6183% (minimum 75%, Missing); spinal cord: 41.5584% (minimum 75%, Missing); urinary bladder: 49.2308% (minimum 70%, Missing)",0.152005,-0.231822,-0.520692,0,80,unavailable,215.1,72.7,15.8,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 3); urinary bladder: 66 nTPM (protected, limit 3); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 3); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (manageable, limit 5); esophagus: 15.7 nTPM (protected, limit 3); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); spleen: 9.7 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); rectum: 8.3 nTPM (protected, limit 3); skin: 7.6 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); thyroid gland: 5.4 nTPM (manageable, limit 5); pancreas: 3.5 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105270,CLIP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 29.6984% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 32.5203% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 22.9308% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 23.0299% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.3031% (minimum 75%, Baseline (adaptation disabled)); colon: 46.8178% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 31.6362% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 29.9625% (minimum 75%, Baseline (adaptation disabled)); midbrain: 35.1455% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 58.3409% (minimum 75%, Baseline (adaptation disabled)); retina: 54.6075% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.6183% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 41.5584% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 49.2308% (minimum 70%, Baseline (adaptation disabled))",0.152005,-0.231822,-0.520692,0,80,unavailable,215.1,72.7,15.8,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 3); urinary bladder: 66 nTPM (protected, limit 3); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 3); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (manageable, limit 5); esophagus: 15.7 nTPM (protected, limit 3); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); spleen: 9.7 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); rectum: 8.3 nTPM (protected, limit 3); skin: 7.6 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); thyroid gland: 5.4 nTPM (manageable, limit 5); pancreas: 3.5 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105270,CLIP3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.00828914,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105428,ZNRF4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248289,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105428,ZNRF4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248289,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105428,ZNRF4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248289,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105428,ZNRF4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248289,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105428,ZNRF4,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.6940% (minimum 99%, Missing); cerebellum: 89.6610% (minimum 95%, Enhanced)",0.05,0.0262335,-0.0533898,0,4,partial,6.1,3.8,0.1,"cerebellum: 6.1 nTPM (vital, limit 6)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105467,SYNGR4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.296234,0.23694,0,4,partial,6.1,3.8,0.1,"cerebellum: 6.1 nTPM (vital, limit 6)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105467,SYNGR4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.296234,0.23694,0,4,partial,6.1,3.8,0.1,"cerebellum: 6.1 nTPM (vital, limit 6)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105467,SYNGR4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.296234,0.23694,0,4,partial,6.1,3.8,0.1,"cerebellum: 6.1 nTPM (vital, limit 6)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105467,SYNGR4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.348113,0.232981,0.14661,0,4,partial,6.1,3.8,0.1,"cerebellum: 6.1 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); cerebral cortex: 1.8 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105467,SYNGR4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.0159% (minimum 99%, Missing); basal ganglia: 95.3668% (minimum 99%, Missing); choroid plexus: 46.6038% (minimum 99%, Missing); hippocampal formation: 96.1089% (minimum 99%, Missing); hypothalamus: 94.6360% (minimum 99%, Missing); lung: 89.4928% (minimum 98%, Approved); pituitary gland: 98.4064% (minimum 99%, Missing); retina: 98.4064% (minimum 99%, Missing)",0.0419679,0.0262846,-0.523962,0,6,partial,28.3,0.6,0.5,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105479,ODAD1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.6038% (minimum 75%, Missing)",0.341968,0.3,-0.283962,0,6,partial,28.3,0.6,0.5,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105479,ODAD1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.6038% (minimum 75%, Missing)",0.341968,0.3,-0.283962,0,6,partial,28.3,0.6,0.5,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105479,ODAD1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.6038% (minimum 75%, Missing)",0.341968,0.3,-0.283962,0,6,partial,28.3,0.6,0.5,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105479,ODAD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.6038% (minimum 75%, Baseline (adaptation disabled))",0.330159,0.276285,-0.283962,0,6,partial,28.3,0.6,0.5,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105479,ODAD1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 97.9107% (minimum 99%, Missing); small intestine: 96.9897% (minimum 99%, Missing)",0.0432563,0.00172479,-0.0201035,0,8,partial,4.3,3.7,1.7,"small intestine: 3.2 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105492,SIGLEC6,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343256,0.271725,0.219897,0,8,partial,4.3,3.7,1.7,"small intestine: 3.2 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105492,SIGLEC6,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343256,0.271725,0.219897,0,8,partial,4.3,3.7,1.7,"small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105492,SIGLEC6,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343256,0.271725,0.219897,0,8,partial,4.3,3.7,1.7,"small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105492,SIGLEC6,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.333779,0.265356,0.209963,0,8,partial,4.3,3.7,1.7,"lung: 4.3 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105492,SIGLEC6,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.0998% (minimum 99%, Missing); skin: 93.8636% (minimum 95%, Missing)",-0.0113636,0.0227885,-0.00900238,0,80,unavailable,0.8,0.3,2.7,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105549,SPMAP2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.288636,0.292788,0.230998,0,80,unavailable,0.8,0.3,2.7,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105549,SPMAP2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.288636,0.292788,0.230998,0,80,unavailable,0.8,0.3,2.7,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105549,SPMAP2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.288636,0.292788,0.230998,0,80,unavailable,0.8,0.3,2.7,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105549,SPMAP2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.288636,0.292788,0.230998,0,80,unavailable,0.8,0.3,2.7,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105549,SPMAP2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.8201% (minimum 95%, Missing); adrenal gland: 45.6140% (minimum 99%, Missing); amygdala: 40.3883% (minimum 99%, Missing); basal ganglia: 38.4473% (minimum 99%, Missing); bone marrow: 68.4211% (minimum 99%, Missing); cerebellum: 54.3081% (minimum 99%, Missing); cerebral cortex: 34.4371% (minimum 99%, Missing); choroid plexus: 78.1955% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 50.9804% (minimum 99%, Missing); esophagus: 45.1193% (minimum 97%, Missing); heart muscle: 62.8399% (minimum 98%, Approved); hippocampal formation: 32.9114% (minimum 99%, Missing); hypothalamus: 61.5385% (minimum 99%, Missing); kidney: 69.1030% (minimum 99%, Missing); liver: 66.8810% (minimum 99%, Missing); lung: 70.2703% (minimum 99%, Missing); lymph node: 80.3089% (minimum 97%, Missing); midbrain: 69.3333% (minimum 99%, Missing); pancreas: 66.0317% (minimum 99%, Missing); parathyroid gland: 50.8557% (minimum 97%, Missing); pituitary gland: 49.8801% (minimum 99%, Missing); rectum: 69.1030% (minimum 97%, Missing); retina: 73.2394% (minimum 99%, Missing); salivary gland: 58.9235% (minimum 97%, Missing); skeletal muscle: 63.4146% (minimum 98%, Approved); skin: 44.7312% (minimum 95%, Missing); small intestine: 56.2162% (minimum 99%, Missing); smooth muscle: 68.8742% (minimum 98%, Approved); spinal cord: 70.7483% (minimum 99%, Missing); spleen: 70.9898% (minimum 95%, Missing); stomach: 58.5915% (minimum 97%, Missing); thymus: 64.7975% (minimum 95%, Missing); thyroid gland: 67.0968% (minimum 95%, Missing); tongue: 68.6469% (minimum 97%, Missing); urinary bladder: 58.4270% (minimum 97%, Missing)",-0.502688,-0.518807,-0.660886,0,1,partial,42.4,25.3,25.7,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); skin: 25.7 nTPM (manageable, limit 5); esophagus: 25.3 nTPM (protected, limit 2); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 2); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 2); stomach: 14.7 nTPM (protected, limit 2); salivary gland: 14.5 nTPM (protected, limit 2); hypothalamus: 13 nTPM (vital, limit 1); colon: 13 nTPM (protected, limit 2); heart muscle: 12.3 nTPM (vital, limit 2); skeletal muscle: 12 nTPM (vital, limit 2); thymus: 11.3 nTPM (manageable, limit 5); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 2); smooth muscle: 9.4 nTPM (vital, limit 2); rectum: 9.3 nTPM (protected, limit 2); kidney: 9.3 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105647,PIK3R2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 45.6140% (minimum 75%, Missing); amygdala: 40.3883% (minimum 75%, Missing); basal ganglia: 38.4473% (minimum 75%, Missing); bone marrow: 68.4211% (minimum 75%, Missing); cerebellum: 54.3081% (minimum 75%, Missing); cerebral cortex: 34.4371% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 50.9804% (minimum 75%, Missing); esophagus: 45.1193% (minimum 70%, Missing); heart muscle: 62.8399% (minimum 70%, Approved); hippocampal formation: 32.9114% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); kidney: 69.1030% (minimum 75%, Missing); liver: 66.8810% (minimum 75%, Missing); lung: 70.2703% (minimum 75%, Missing); midbrain: 69.3333% (minimum 75%, Missing); pancreas: 66.0317% (minimum 75%, Missing); parathyroid gland: 50.8557% (minimum 70%, Missing); pituitary gland: 49.8801% (minimum 75%, Missing); rectum: 69.1030% (minimum 70%, Missing); retina: 73.2394% (minimum 75%, Missing); salivary gland: 58.9235% (minimum 70%, Missing); skeletal muscle: 63.4146% (minimum 70%, Approved); skin: 44.7312% (minimum 65%, Missing); small intestine: 56.2162% (minimum 75%, Missing); smooth muscle: 68.8742% (minimum 70%, Approved); spinal cord: 70.7483% (minimum 75%, Missing); stomach: 58.5915% (minimum 70%, Missing); thymus: 64.7975% (minimum 65%, Missing); tongue: 68.6469% (minimum 70%, Missing); urinary bladder: 58.4270% (minimum 70%, Missing)",-0.202688,-0.248807,-0.420886,0,1,partial,42.4,25.3,25.7,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); skin: 25.7 nTPM (manageable, limit 5); esophagus: 25.3 nTPM (protected, limit 2); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 2); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 2); stomach: 14.7 nTPM (protected, limit 2); salivary gland: 14.5 nTPM (protected, limit 2); hypothalamus: 13 nTPM (vital, limit 1); colon: 13 nTPM (protected, limit 2); heart muscle: 12.3 nTPM (vital, limit 2); skeletal muscle: 12 nTPM (vital, limit 2); thymus: 11.3 nTPM (manageable, limit 5); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 2); smooth muscle: 9.4 nTPM (vital, limit 2); rectum: 9.3 nTPM (protected, limit 2); kidney: 9.3 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105647,PIK3R2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 45.6140% (minimum 75%, Missing); amygdala: 40.3883% (minimum 75%, Missing); basal ganglia: 38.4473% (minimum 75%, Missing); bone marrow: 68.4211% (minimum 75%, Missing); cerebellum: 54.3081% (minimum 75%, Missing); cerebral cortex: 34.4371% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 50.9804% (minimum 75%, Missing); esophagus: 45.1193% (minimum 70%, Missing); heart muscle: 62.8399% (minimum 70%, Approved); hippocampal formation: 32.9114% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); kidney: 69.1030% (minimum 75%, Missing); liver: 66.8810% (minimum 75%, Missing); lung: 70.2703% (minimum 75%, Missing); midbrain: 69.3333% (minimum 75%, Missing); pancreas: 66.0317% (minimum 75%, Missing); parathyroid gland: 50.8557% (minimum 70%, Missing); pituitary gland: 49.8801% (minimum 75%, Missing); rectum: 69.1030% (minimum 70%, Missing); retina: 73.2394% (minimum 75%, Missing); salivary gland: 58.9235% (minimum 70%, Missing); skeletal muscle: 63.4146% (minimum 70%, Approved); skin: 44.7312% (minimum 65%, Missing); small intestine: 56.2162% (minimum 75%, Missing); smooth muscle: 68.8742% (minimum 70%, Approved); spinal cord: 70.7483% (minimum 75%, Missing); stomach: 58.5915% (minimum 70%, Missing); thymus: 64.7975% (minimum 65%, Missing); tongue: 68.6469% (minimum 70%, Missing); urinary bladder: 58.4270% (minimum 70%, Missing)",-0.202688,-0.248807,-0.420886,0,1,partial,42.4,25.3,25.7,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); skin: 25.7 nTPM (manageable, limit 5); esophagus: 25.3 nTPM (protected, limit 3); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 3); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 3); stomach: 14.7 nTPM (protected, limit 3); salivary gland: 14.5 nTPM (protected, limit 3); hypothalamus: 13 nTPM (vital, limit 1); colon: 13 nTPM (protected, limit 3); heart muscle: 12.3 nTPM (vital, limit 2); skeletal muscle: 12 nTPM (vital, limit 2); thymus: 11.3 nTPM (manageable, limit 5); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 3); smooth muscle: 9.4 nTPM (vital, limit 2); rectum: 9.3 nTPM (protected, limit 3); kidney: 9.3 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105647,PIK3R2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 45.6140% (minimum 75%, Missing); amygdala: 40.3883% (minimum 75%, Missing); basal ganglia: 38.4473% (minimum 75%, Missing); bone marrow: 68.4211% (minimum 75%, Missing); cerebellum: 54.3081% (minimum 75%, Missing); cerebral cortex: 34.4371% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 50.9804% (minimum 75%, Missing); esophagus: 45.1193% (minimum 70%, Missing); heart muscle: 62.8399% (minimum 70%, Approved); hippocampal formation: 32.9114% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); kidney: 69.1030% (minimum 75%, Missing); liver: 66.8810% (minimum 75%, Missing); lung: 70.2703% (minimum 75%, Missing); midbrain: 69.3333% (minimum 75%, Missing); pancreas: 66.0317% (minimum 75%, Missing); parathyroid gland: 50.8557% (minimum 70%, Missing); pituitary gland: 49.8801% (minimum 75%, Missing); rectum: 69.1030% (minimum 70%, Missing); retina: 73.2394% (minimum 75%, Missing); salivary gland: 58.9235% (minimum 70%, Missing); skeletal muscle: 63.4146% (minimum 70%, Approved); skin: 44.7312% (minimum 65%, Missing); small intestine: 56.2162% (minimum 75%, Missing); smooth muscle: 68.8742% (minimum 70%, Approved); spinal cord: 70.7483% (minimum 75%, Missing); stomach: 58.5915% (minimum 70%, Missing); thymus: 64.7975% (minimum 65%, Missing); tongue: 68.6469% (minimum 70%, Missing); urinary bladder: 58.4270% (minimum 70%, Missing)",-0.202688,-0.248807,-0.420886,0,1,partial,42.4,25.3,25.7,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); skin: 25.7 nTPM (manageable, limit 5); esophagus: 25.3 nTPM (protected, limit 3); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 3); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 3); stomach: 14.7 nTPM (protected, limit 3); salivary gland: 14.5 nTPM (protected, limit 3); hypothalamus: 13 nTPM (vital, limit 1); colon: 13 nTPM (protected, limit 3); heart muscle: 12.3 nTPM (vital, limit 2); skeletal muscle: 12 nTPM (vital, limit 2); thymus: 11.3 nTPM (manageable, limit 5); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 3); smooth muscle: 9.4 nTPM (vital, limit 2); rectum: 9.3 nTPM (protected, limit 3); kidney: 9.3 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105647,PIK3R2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 45.6140% (minimum 75%, Baseline (adaptation disabled)); amygdala: 40.3883% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 38.4473% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 68.4211% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.3081% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 34.4371% (minimum 75%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.9804% (minimum 75%, Baseline (adaptation disabled)); esophagus: 45.1193% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 62.8399% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 32.9114% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.5385% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.1030% (minimum 75%, Baseline (adaptation disabled)); liver: 66.8810% (minimum 75%, Baseline (adaptation disabled)); lung: 70.2703% (minimum 75%, Baseline (adaptation disabled)); midbrain: 69.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.0317% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.8557% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 49.8801% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.1030% (minimum 70%, Baseline (adaptation disabled)); retina: 73.2394% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.9235% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 63.4146% (minimum 75%, Baseline (adaptation disabled)); skin: 44.7312% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.2162% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.8742% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.7483% (minimum 75%, Baseline (adaptation disabled)); stomach: 58.5915% (minimum 70%, Baseline (adaptation disabled)); thymus: 64.7975% (minimum 65%, Baseline (adaptation disabled)); tongue: 68.6469% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.4270% (minimum 70%, Baseline (adaptation disabled))",-0.202688,-0.248807,-0.420886,0,1,partial,42.4,25.3,25.7,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); skin: 25.7 nTPM (manageable, limit 5); esophagus: 25.3 nTPM (protected, limit 3); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 3); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 3); stomach: 14.7 nTPM (protected, limit 3); salivary gland: 14.5 nTPM (protected, limit 3); hypothalamus: 13 nTPM (vital, limit 1); colon: 13 nTPM (protected, limit 3); heart muscle: 12.3 nTPM (vital, limit 1); skeletal muscle: 12 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 3); smooth muscle: 9.4 nTPM (vital, limit 1); rectum: 9.3 nTPM (protected, limit 3); kidney: 9.3 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105647,PIK3R2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.3608% (minimum 99%, Missing); amygdala: 97.8836% (minimum 99%, Missing); basal ganglia: 98.9305% (minimum 99%, Missing); bone marrow: 97.8836% (minimum 99%, Missing); cerebellum: 96.3542% (minimum 99%, Missing); cerebral cortex: 98.4043% (minimum 99%, Missing); choroid plexus: 97.3684% (minimum 99%, Missing); colon: 95.3608% (minimum 97%, Missing); duodenum: 92.5000% (minimum 99%, Missing); esophagus: 91.1330% (minimum 97%, Missing); heart muscle: 97.8836% (minimum 99%, Missing); hippocampal formation: 98.4043% (minimum 99%, Missing); hypothalamus: 98.4043% (minimum 99%, Missing); kidney: 95.8549% (minimum 99%, Missing); liver: 93.4343% (minimum 99%, Missing); lung: 96.8586% (minimum 99%, Missing); midbrain: 98.4043% (minimum 99%, Missing); pancreas: 88.9423% (minimum 99%, Missing); parathyroid gland: 94.8718% (minimum 97%, Missing); pituitary gland: 96.8586% (minimum 99%, Missing); retina: 98.4043% (minimum 99%, Missing); salivary gland: 90.6863% (minimum 97%, Missing); skeletal muscle: 98.9305% (minimum 99%, Missing); skin: 92.0398% (minimum 95%, Missing); small intestine: 94.3878% (minimum 99%, Missing); smooth muscle: 98.4043% (minimum 99%, Missing); spinal cord: 98.4043% (minimum 99%, Missing); stomach: 95.3608% (minimum 97%, Missing); urinary bladder: 96.8586% (minimum 97%, Missing)",-0.029602,-0.0631373,-0.100577,0,80,unavailable,2.3,1.9,1.6,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105672,ETV2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.270398,0.206863,0.139423,0,80,unavailable,2.3,1.9,1.6,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105672,ETV2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.270398,0.206863,0.139423,0,80,unavailable,2.3,1.9,1.6,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105672,ETV2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.270398,0.206863,0.139423,0,80,unavailable,2.3,1.9,1.6,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105672,ETV2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.270398,0.206863,0.139423,0,80,unavailable,2.3,1.9,1.6,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105672,ETV2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.7204% (minimum 99%, Missing)",0.05,0.03,-0.00279639,0,3,partial,5,6.3,13.5,"retina: 3.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105679,GAPDHS,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.237204,0,3,partial,5,6.3,13.5,"retina: 3.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105679,GAPDHS,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.237204,0,3,partial,5,6.3,13.5,"retina: 3.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105679,GAPDHS,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.237204,0,3,partial,5,6.3,13.5,"retina: 3.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105679,GAPDHS,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.301051,0.276545,0.231294,0,3,partial,5,6.3,13.5,"skin: 13.5 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 3); spleen: 5.1 nTPM (manageable, limit 5); pancreas: 5 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); heart muscle: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105679,GAPDHS,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.3955% (minimum 99%, Missing); amygdala: 65.4397% (minimum 99%, Missing); basal ganglia: 60.8365% (minimum 99%, Missing); bone marrow: 92.2190% (minimum 99%, Missing); cerebellum: 49.4590% (minimum 99%, Missing); cerebral cortex: 53.9629% (minimum 99%, Missing); choroid plexus: 82.0513% (minimum 99%, Missing); colon: 66.8058% (minimum 97%, Missing); duodenum: 97.8593% (minimum 99%, Missing); esophagus: 95.8084% (minimum 97%, Missing); heart muscle: 86.9565% (minimum 99%, Missing); hippocampal formation: 61.5385% (minimum 99%, Missing); hypothalamus: 67.5105% (minimum 99%, Missing); kidney: 82.4742% (minimum 99%, Missing); lung: 98.4615% (minimum 99%, Missing); midbrain: 78.2396% (minimum 99%, Missing); pancreas: 93.2945% (minimum 99%, Missing); parathyroid gland: 69.8690% (minimum 97%, Missing); pituitary gland: 64.2570% (minimum 99%, Missing); retina: 72.8929% (minimum 99%, Missing); skeletal muscle: 98.4615% (minimum 99%, Missing); small intestine: 90.6516% (minimum 99%, Missing); smooth muscle: 86.9565% (minimum 99%, Missing); spinal cord: 89.8876% (minimum 99%, Missing); stomach: 86.2534% (minimum 97%, Missing); thyroid gland: 74.4186% (minimum 95%, Missing); urinary bladder: 86.9565% (minimum 97%, Missing)",-0.205814,-0.301942,-0.49541,0,80,unavailable,32.7,15.9,11,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 2); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 2); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105737,GRIK5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.4397% (minimum 75%, Missing); basal ganglia: 60.8365% (minimum 75%, Missing); cerebellum: 49.4590% (minimum 75%, Missing); cerebral cortex: 53.9629% (minimum 75%, Missing); colon: 66.8058% (minimum 70%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 67.5105% (minimum 75%, Missing); parathyroid gland: 69.8690% (minimum 70%, Missing); pituitary gland: 64.2570% (minimum 75%, Missing); retina: 72.8929% (minimum 75%, Missing)",0.094186,-0.0319415,-0.25541,0,80,unavailable,32.7,15.9,11,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 2); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 2); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105737,GRIK5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.4397% (minimum 75%, Missing); basal ganglia: 60.8365% (minimum 75%, Missing); cerebellum: 49.4590% (minimum 75%, Missing); cerebral cortex: 53.9629% (minimum 75%, Missing); colon: 66.8058% (minimum 70%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 67.5105% (minimum 75%, Missing); parathyroid gland: 69.8690% (minimum 70%, Missing); pituitary gland: 64.2570% (minimum 75%, Missing); retina: 72.8929% (minimum 75%, Missing)",0.094186,-0.0319415,-0.25541,0,80,unavailable,32.7,15.9,11,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 3); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 3); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105737,GRIK5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.4397% (minimum 75%, Missing); basal ganglia: 60.8365% (minimum 75%, Missing); cerebellum: 49.4590% (minimum 75%, Missing); cerebral cortex: 53.9629% (minimum 75%, Missing); colon: 66.8058% (minimum 70%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 67.5105% (minimum 75%, Missing); parathyroid gland: 69.8690% (minimum 70%, Missing); pituitary gland: 64.2570% (minimum 75%, Missing); retina: 72.8929% (minimum 75%, Missing)",0.094186,-0.0319415,-0.25541,0,80,unavailable,32.7,15.9,11,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 3); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 3); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105737,GRIK5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.4397% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.8365% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 49.4590% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.9629% (minimum 75%, Baseline (adaptation disabled)); colon: 66.8058% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 61.5385% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.5105% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.8690% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 64.2570% (minimum 75%, Baseline (adaptation disabled)); retina: 72.8929% (minimum 75%, Baseline (adaptation disabled))",0.094186,-0.0319415,-0.25541,0,80,unavailable,32.7,15.9,11,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 3); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 3); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105737,GRIK5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.1594% (minimum 95%, Missing); adrenal gland: 70.0000% (minimum 99%, Missing); amygdala: 85.4962% (minimum 99%, Missing); basal ganglia: 86.8217% (minimum 99%, Missing); bone marrow: 70.0000% (minimum 99%, Missing); cerebellum: 79.4326% (minimum 99%, Missing); cerebral cortex: 82.3529% (minimum 99%, Missing); colon: 85.4962% (minimum 97%, Missing); duodenum: 96.5517% (minimum 99%, Missing); esophagus: 80.0000% (minimum 97%, Missing); heart muscle: 86.8217% (minimum 99%, Missing); hippocampal formation: 86.8217% (minimum 99%, Missing); hypothalamus: 85.4962% (minimum 99%, Missing); kidney: 82.3529% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); lung: 86.8217% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 84.8485% (minimum 99%, Missing); pancreas: 58.6387% (minimum 99%, Missing); parathyroid gland: 84.8485% (minimum 97%, Missing); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 82.3529% (minimum 97%, Missing); retina: 91.8033% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 94.1176% (minimum 99%, Missing); skin: 80.5755% (minimum 95%, Missing); small intestine: 83.5821% (minimum 99%, Missing); smooth muscle: 82.9630% (minimum 99%, Missing); spinal cord: 82.3529% (minimum 99%, Missing); spleen: 76.1905% (minimum 95%, Missing); stomach: 67.4699% (minimum 97%, Missing); thymus: 68.2927% (minimum 95%, Missing); thyroid gland: 59.8930% (minimum 95%, Missing); urinary bladder: 83.5821% (minimum 97%, Missing)",-0.35107,-0.303333,-0.403613,0,5,partial,7.9,5.6,7.5,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); salivary gland: 2.8 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105750,ZNF85,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); bone marrow: 70.0000% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 58.6387% (minimum 75%, Missing); stomach: 67.4699% (minimum 70%, Missing); thyroid gland: 59.8930% (minimum 65%, Missing)",-0.0510695,-0.0333333,-0.163613,0,5,partial,7.9,5.6,7.5,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); salivary gland: 2.8 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105750,ZNF85,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); bone marrow: 70.0000% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 58.6387% (minimum 75%, Missing); stomach: 67.4699% (minimum 70%, Missing); thyroid gland: 59.8930% (minimum 65%, Missing)",-0.0510695,-0.0333333,-0.163613,0,5,partial,7.9,5.6,7.5,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105750,ZNF85,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); bone marrow: 70.0000% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 58.6387% (minimum 75%, Missing); stomach: 67.4699% (minimum 70%, Missing); thyroid gland: 59.8930% (minimum 65%, Missing)",-0.0510695,-0.0333333,-0.163613,0,5,partial,7.9,5.6,7.5,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105750,ZNF85,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 70.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); pancreas: 58.6387% (minimum 75%, Baseline (adaptation disabled)); stomach: 67.4699% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 59.8930% (minimum 65%, Baseline (adaptation disabled))",-0.0510695,-0.0333333,-0.163613,0,5,partial,7.9,5.6,7.5,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105750,ZNF85,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.0681% (minimum 90%, Approved); adrenal gland: 60.8939% (minimum 99%, Missing); amygdala: 75.1724% (minimum 99%, Missing); basal ganglia: 74.6575% (minimum 99%, Missing); bone marrow: 63.0058% (minimum 98%, Approved); cerebellum: 67.7019% (minimum 99%, Missing); cerebral cortex: 60.2210% (minimum 99%, Missing); choroid plexus: 73.1544% (minimum 99%, Missing); colon: 56.1856% (minimum 97%, Missing); duodenum: 56.1856% (minimum 99%, Missing); esophagus: 57.6720% (minimum 97%, Missing); heart muscle: 52.9126% (minimum 98%, Approved); hippocampal formation: 73.6486% (minimum 99%, Missing); hypothalamus: 72.1854% (minimum 99%, Missing); kidney: 47.3913% (minimum 99%, Missing); liver: 37.5862% (minimum 98%, Approved); lung: 66.0606% (minimum 99%, Missing); lymph node: 50.6977% (minimum 97%, Missing); midbrain: 71.7105% (minimum 99%, Missing); pancreas: 59.5628% (minimum 99%, Missing); parathyroid gland: 58.2888% (minimum 97%, Missing); pituitary gland: 71.2418% (minimum 99%, Missing); rectum: 53.9604% (minimum 97%, Missing); retina: 60.8939% (minimum 99%, Missing); salivary gland: 64.8810% (minimum 97%, Missing); skeletal muscle: 48.0176% (minimum 99%, Missing); skin: 62.2857% (minimum 95%, Missing); small intestine: 61.2360% (minimum 99%, Missing); smooth muscle: 61.2360% (minimum 99%, Missing); spinal cord: 70.7792% (minimum 99%, Missing); spleen: 60.2210% (minimum 95%, Missing); stomach: 51.1737% (minimum 97%, Missing); thymus: 46.7811% (minimum 95%, Missing); thyroid gland: 53.4314% (minimum 95%, Missing); tongue: 52.9126% (minimum 97%, Missing); urinary bladder: 54.2289% (minimum 97%, Missing)",-0.482189,-0.463023,-0.604138,0,8,partial,18.1,10.6,12.4,"liver: 18.1 nTPM (vital, limit 2); thymus: 12.4 nTPM (manageable, limit 5); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 2); stomach: 10.4 nTPM (protected, limit 2); tongue: 9.7 nTPM (protected, limit 2); heart muscle: 9.7 nTPM (vital, limit 2); thyroid gland: 9.5 nTPM (manageable, limit 5); rectum: 9.3 nTPM (protected, limit 2); urinary bladder: 9.2 nTPM (protected, limit 2); colon: 8.5 nTPM (protected, limit 2); duodenum: 8.5 nTPM (vital, limit 1); esophagus: 8 nTPM (protected, limit 2); parathyroid gland: 7.8 nTPM (protected, limit 2); pancreas: 7.4 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); skin: 6.6 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 2); lung: 5.6 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105793,GTPBP10,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.0681% (minimum 60%, Approved); adrenal gland: 60.8939% (minimum 75%, Missing); basal ganglia: 74.6575% (minimum 75%, Missing); bone marrow: 63.0058% (minimum 70%, Approved); cerebellum: 67.7019% (minimum 75%, Missing); cerebral cortex: 60.2210% (minimum 75%, Missing); choroid plexus: 73.1544% (minimum 75%, Missing); colon: 56.1856% (minimum 70%, Missing); duodenum: 56.1856% (minimum 75%, Missing); esophagus: 57.6720% (minimum 70%, Missing); heart muscle: 52.9126% (minimum 70%, Approved); hippocampal formation: 73.6486% (minimum 75%, Missing); hypothalamus: 72.1854% (minimum 75%, Missing); kidney: 47.3913% (minimum 75%, Missing); liver: 37.5862% (minimum 70%, Approved); lung: 66.0606% (minimum 75%, Missing); lymph node: 50.6977% (minimum 70%, Missing); midbrain: 71.7105% (minimum 75%, Missing); pancreas: 59.5628% (minimum 75%, Missing); parathyroid gland: 58.2888% (minimum 70%, Missing); pituitary gland: 71.2418% (minimum 75%, Missing); rectum: 53.9604% (minimum 70%, Missing); retina: 60.8939% (minimum 75%, Missing); salivary gland: 64.8810% (minimum 70%, Missing); skeletal muscle: 48.0176% (minimum 75%, Missing); skin: 62.2857% (minimum 65%, Missing); small intestine: 61.2360% (minimum 75%, Missing); smooth muscle: 61.2360% (minimum 75%, Missing); spinal cord: 70.7792% (minimum 75%, Missing); spleen: 60.2210% (minimum 65%, Missing); stomach: 51.1737% (minimum 70%, Missing); thymus: 46.7811% (minimum 65%, Missing); thyroid gland: 53.4314% (minimum 65%, Missing); tongue: 52.9126% (minimum 70%, Missing); urinary bladder: 54.2289% (minimum 70%, Missing)",-0.182189,-0.193023,-0.324138,0,8,partial,18.1,10.6,12.4,"liver: 18.1 nTPM (vital, limit 2); thymus: 12.4 nTPM (manageable, limit 5); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 2); stomach: 10.4 nTPM (protected, limit 2); tongue: 9.7 nTPM (protected, limit 2); heart muscle: 9.7 nTPM (vital, limit 2); thyroid gland: 9.5 nTPM (manageable, limit 5); rectum: 9.3 nTPM (protected, limit 2); urinary bladder: 9.2 nTPM (protected, limit 2); colon: 8.5 nTPM (protected, limit 2); duodenum: 8.5 nTPM (vital, limit 1); esophagus: 8 nTPM (protected, limit 2); parathyroid gland: 7.8 nTPM (protected, limit 2); pancreas: 7.4 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); skin: 6.6 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 2); lung: 5.6 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105793,GTPBP10,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.0681% (minimum 60%, Approved); adrenal gland: 60.8939% (minimum 75%, Missing); basal ganglia: 74.6575% (minimum 75%, Missing); bone marrow: 63.0058% (minimum 70%, Approved); cerebellum: 67.7019% (minimum 75%, Missing); cerebral cortex: 60.2210% (minimum 75%, Missing); choroid plexus: 73.1544% (minimum 75%, Missing); colon: 56.1856% (minimum 70%, Missing); duodenum: 56.1856% (minimum 75%, Missing); esophagus: 57.6720% (minimum 70%, Missing); heart muscle: 52.9126% (minimum 70%, Approved); hippocampal formation: 73.6486% (minimum 75%, Missing); hypothalamus: 72.1854% (minimum 75%, Missing); kidney: 47.3913% (minimum 75%, Missing); liver: 37.5862% (minimum 70%, Approved); lung: 66.0606% (minimum 75%, Missing); lymph node: 50.6977% (minimum 70%, Missing); midbrain: 71.7105% (minimum 75%, Missing); pancreas: 59.5628% (minimum 75%, Missing); parathyroid gland: 58.2888% (minimum 70%, Missing); pituitary gland: 71.2418% (minimum 75%, Missing); rectum: 53.9604% (minimum 70%, Missing); retina: 60.8939% (minimum 75%, Missing); salivary gland: 64.8810% (minimum 70%, Missing); skeletal muscle: 48.0176% (minimum 75%, Missing); skin: 62.2857% (minimum 65%, Missing); small intestine: 61.2360% (minimum 75%, Missing); smooth muscle: 61.2360% (minimum 75%, Missing); spinal cord: 70.7792% (minimum 75%, Missing); spleen: 60.2210% (minimum 65%, Missing); stomach: 51.1737% (minimum 70%, Missing); thymus: 46.7811% (minimum 65%, Missing); thyroid gland: 53.4314% (minimum 65%, Missing); tongue: 52.9126% (minimum 70%, Missing); urinary bladder: 54.2289% (minimum 70%, Missing)",-0.182189,-0.193023,-0.324138,0,8,partial,18.1,10.6,12.4,"liver: 18.1 nTPM (vital, limit 2); thymus: 12.4 nTPM (manageable, limit 5); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 3); stomach: 10.4 nTPM (protected, limit 3); tongue: 9.7 nTPM (protected, limit 3); heart muscle: 9.7 nTPM (vital, limit 2); thyroid gland: 9.5 nTPM (manageable, limit 5); rectum: 9.3 nTPM (protected, limit 3); urinary bladder: 9.2 nTPM (protected, limit 3); colon: 8.5 nTPM (protected, limit 3); duodenum: 8.5 nTPM (vital, limit 1); esophagus: 8 nTPM (protected, limit 3); parathyroid gland: 7.8 nTPM (protected, limit 3); pancreas: 7.4 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); skin: 6.6 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 3); lung: 5.6 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105793,GTPBP10,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.0681% (minimum 60%, Approved); adrenal gland: 60.8939% (minimum 75%, Missing); basal ganglia: 74.6575% (minimum 75%, Missing); bone marrow: 63.0058% (minimum 70%, Approved); cerebellum: 67.7019% (minimum 75%, Missing); cerebral cortex: 60.2210% (minimum 75%, Missing); choroid plexus: 73.1544% (minimum 75%, Missing); colon: 56.1856% (minimum 70%, Missing); duodenum: 56.1856% (minimum 75%, Missing); esophagus: 57.6720% (minimum 70%, Missing); heart muscle: 52.9126% (minimum 70%, Approved); hippocampal formation: 73.6486% (minimum 75%, Missing); hypothalamus: 72.1854% (minimum 75%, Missing); kidney: 47.3913% (minimum 75%, Missing); liver: 37.5862% (minimum 70%, Approved); lung: 66.0606% (minimum 75%, Missing); lymph node: 50.6977% (minimum 70%, Missing); midbrain: 71.7105% (minimum 75%, Missing); pancreas: 59.5628% (minimum 75%, Missing); parathyroid gland: 58.2888% (minimum 70%, Missing); pituitary gland: 71.2418% (minimum 75%, Missing); rectum: 53.9604% (minimum 70%, Missing); retina: 60.8939% (minimum 75%, Missing); salivary gland: 64.8810% (minimum 70%, Missing); skeletal muscle: 48.0176% (minimum 75%, Missing); skin: 62.2857% (minimum 65%, Missing); small intestine: 61.2360% (minimum 75%, Missing); smooth muscle: 61.2360% (minimum 75%, Missing); spinal cord: 70.7792% (minimum 75%, Missing); spleen: 60.2210% (minimum 65%, Missing); stomach: 51.1737% (minimum 70%, Missing); thymus: 46.7811% (minimum 65%, Missing); thyroid gland: 53.4314% (minimum 65%, Missing); tongue: 52.9126% (minimum 70%, Missing); urinary bladder: 54.2289% (minimum 70%, Missing)",-0.182189,-0.193023,-0.324138,0,8,partial,18.1,10.6,12.4,"liver: 18.1 nTPM (vital, limit 2); thymus: 12.4 nTPM (manageable, limit 5); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 3); stomach: 10.4 nTPM (protected, limit 3); tongue: 9.7 nTPM (protected, limit 3); heart muscle: 9.7 nTPM (vital, limit 2); thyroid gland: 9.5 nTPM (manageable, limit 5); rectum: 9.3 nTPM (protected, limit 3); urinary bladder: 9.2 nTPM (protected, limit 3); colon: 8.5 nTPM (protected, limit 3); duodenum: 8.5 nTPM (vital, limit 1); esophagus: 8 nTPM (protected, limit 3); parathyroid gland: 7.8 nTPM (protected, limit 3); pancreas: 7.4 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); skin: 6.6 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 3); lung: 5.6 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105793,GTPBP10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.0681% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.8939% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.6575% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 63.0058% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.7019% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.2210% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.1544% (minimum 75%, Baseline (adaptation disabled)); colon: 56.1856% (minimum 70%, Baseline (adaptation disabled)); duodenum: 56.1856% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.6720% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.9126% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.6486% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.1854% (minimum 75%, Baseline (adaptation disabled)); kidney: 47.3913% (minimum 75%, Baseline (adaptation disabled)); liver: 37.5862% (minimum 75%, Baseline (adaptation disabled)); lung: 66.0606% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.6977% (minimum 70%, Baseline (adaptation disabled)); midbrain: 71.7105% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.5628% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.2888% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.2418% (minimum 75%, Baseline (adaptation disabled)); rectum: 53.9604% (minimum 70%, Baseline (adaptation disabled)); retina: 60.8939% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.8810% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 48.0176% (minimum 75%, Baseline (adaptation disabled)); skin: 62.2857% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.2360% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.2360% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.7792% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.2210% (minimum 65%, Baseline (adaptation disabled)); stomach: 51.1737% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.7811% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.4314% (minimum 65%, Baseline (adaptation disabled)); tongue: 52.9126% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 54.2289% (minimum 70%, Baseline (adaptation disabled))",-0.182189,-0.193023,-0.374138,0,8,partial,18.1,10.6,12.4,"liver: 18.1 nTPM (vital, limit 1); thymus: 12.4 nTPM (manageable, limit 5); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 3); stomach: 10.4 nTPM (protected, limit 3); tongue: 9.7 nTPM (protected, limit 3); heart muscle: 9.7 nTPM (vital, limit 1); thyroid gland: 9.5 nTPM (manageable, limit 5); rectum: 9.3 nTPM (protected, limit 3); urinary bladder: 9.2 nTPM (protected, limit 3); colon: 8.5 nTPM (protected, limit 3); duodenum: 8.5 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); esophagus: 8 nTPM (protected, limit 3); parathyroid gland: 7.8 nTPM (protected, limit 3); pancreas: 7.4 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); adrenal gland: 7 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); skin: 6.6 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); salivary gland: 5.9 nTPM (protected, limit 3); lung: 5.6 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105793,GTPBP10,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 92.5885% (minimum 95%, Enhanced); pituitary gland: 98.9948% (minimum 99%, Missing); retina: 94.8658% (minimum 99%, Missing)",0.0428142,0.0285976,-0.0413425,0,4,partial,74.1,25.6,49.6,"pancreas: 74.1 nTPM (vital, limit 6); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (manageable, limit 30); adrenal gland: 27.4 nTPM (vital, limit 6); urinary bladder: 25.6 nTPM (protected, limit 12); liver: 20.6 nTPM (vital, limit 6); kidney: 19.8 nTPM (vital, limit 6); lung: 10.9 nTPM (vital, limit 6); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 6); heart muscle: 7.5 nTPM (vital, limit 6); thymus: 6.7 nTPM (manageable, limit 5); hypothalamus: 4.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105825,TFPI2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342814,0.298598,0.198658,0,4,partial,74.1,25.6,49.6,"pancreas: 74.1 nTPM (vital, limit 6); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (manageable, limit 30); adrenal gland: 27.4 nTPM (vital, limit 6); urinary bladder: 25.6 nTPM (protected, limit 12); liver: 20.6 nTPM (vital, limit 6); kidney: 19.8 nTPM (vital, limit 6); lung: 10.9 nTPM (vital, limit 6); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 6); heart muscle: 7.5 nTPM (vital, limit 6); thymus: 6.7 nTPM (manageable, limit 5); hypothalamus: 4.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105825,TFPI2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342814,0.298598,0.198658,0,4,partial,74.1,25.6,49.6,"pancreas: 74.1 nTPM (vital, limit 6); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (manageable, limit 30); adrenal gland: 27.4 nTPM (vital, limit 6); urinary bladder: 25.6 nTPM (protected, limit 12); liver: 20.6 nTPM (vital, limit 6); kidney: 19.8 nTPM (vital, limit 6); lung: 10.9 nTPM (vital, limit 6); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 6); heart muscle: 7.5 nTPM (vital, limit 6); thymus: 6.7 nTPM (manageable, limit 5); hypothalamus: 4.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105825,TFPI2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342814,0.298598,0.198658,0,4,partial,74.1,25.6,49.6,"pancreas: 74.1 nTPM (vital, limit 6); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (manageable, limit 30); adrenal gland: 27.4 nTPM (vital, limit 6); urinary bladder: 25.6 nTPM (protected, limit 12); liver: 20.6 nTPM (vital, limit 6); kidney: 19.8 nTPM (vital, limit 6); lung: 10.9 nTPM (vital, limit 6); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 6); heart muscle: 7.5 nTPM (vital, limit 6); thymus: 6.7 nTPM (manageable, limit 5); hypothalamus: 4.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105825,TFPI2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.299144,0.273089,0.175885,0,4,partial,74.1,25.6,49.6,"pancreas: 74.1 nTPM (vital, limit 1); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 3); liver: 20.6 nTPM (vital, limit 1); kidney: 19.8 nTPM (vital, limit 1); lung: 10.9 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); thymus: 6.7 nTPM (manageable, limit 5); stomach: 4.9 nTPM (protected, limit 3); hypothalamus: 4.3 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); colon: 3.4 nTPM (protected, limit 3); cerebral cortex: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105825,TFPI2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.5294% (minimum 99%, Missing); amygdala: 98.0392% (minimum 99%, Missing); basal ganglia: 98.0392% (minimum 99%, Missing); bone marrow: 10.3950% (minimum 99%, Missing); cerebral cortex: 73.5294% (minimum 99%, Missing); choroid plexus: 89.2857% (minimum 99%, Missing); colon: 55.5556% (minimum 97%, Missing); duodenum: 55.5556% (minimum 99%, Missing); esophagus: 74.6269% (minimum 80%, Enhanced); heart muscle: 75.7576% (minimum 95%, Enhanced); hippocampal formation: 98.0392% (minimum 99%, Missing); hypothalamus: 96.1538% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 72.4638% (minimum 99%, Missing); lung: 51.5464% (minimum 95%, Enhanced); lymph node: 21.2766% (minimum 97%, Missing); midbrain: 94.3396% (minimum 99%, Missing); pancreas: 90.9091% (minimum 95%, Enhanced); pituitary gland: 96.1538% (minimum 99%, Missing); rectum: 57.4713% (minimum 97%, Missing); retina: 98.0392% (minimum 99%, Missing); skeletal muscle: 94.3396% (minimum 95%, Enhanced); skin: 87.7193% (minimum 95%, Missing); small intestine: 54.3478% (minimum 99%, Missing); smooth muscle: 65.7895% (minimum 95%, Enhanced); spinal cord: 90.9091% (minimum 99%, Missing); spleen: 31.8471% (minimum 95%, Missing); stomach: 56.8182% (minimum 97%, Missing); thymus: 23.8095% (minimum 95%, Missing); thyroid gland: 83.3333% (minimum 95%, Missing); tongue: 84.7458% (minimum 97%, Missing); urinary bladder: 54.3478% (minimum 97%, Missing)",-0.711905,-0.757234,-0.88605,0,3,partial,43.1,18.5,16,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 2); thymus: 16 nTPM (manageable, limit 5); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); rectum: 3.7 nTPM (protected, limit 2); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105851,PIK3CG,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.5294% (minimum 75%, Missing); bone marrow: 10.3950% (minimum 75%, Missing); cerebral cortex: 73.5294% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 55.5556% (minimum 75%, Missing); liver: 72.4638% (minimum 75%, Missing); lung: 51.5464% (minimum 60%, Enhanced); lymph node: 21.2766% (minimum 70%, Missing); rectum: 57.4713% (minimum 70%, Missing); small intestine: 54.3478% (minimum 75%, Missing); spleen: 31.8471% (minimum 65%, Missing); stomach: 56.8182% (minimum 70%, Missing); thymus: 23.8095% (minimum 65%, Missing); urinary bladder: 54.3478% (minimum 70%, Missing)",-0.411905,-0.487234,-0.64605,0,3,partial,43.1,18.5,16,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 2); thymus: 16 nTPM (manageable, limit 5); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); rectum: 3.7 nTPM (protected, limit 2); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105851,PIK3CG,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.5294% (minimum 75%, Missing); bone marrow: 10.3950% (minimum 75%, Missing); cerebral cortex: 73.5294% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 55.5556% (minimum 75%, Missing); liver: 72.4638% (minimum 75%, Missing); lung: 51.5464% (minimum 60%, Enhanced); lymph node: 21.2766% (minimum 70%, Missing); rectum: 57.4713% (minimum 70%, Missing); small intestine: 54.3478% (minimum 75%, Missing); spleen: 31.8471% (minimum 65%, Missing); stomach: 56.8182% (minimum 70%, Missing); thymus: 23.8095% (minimum 65%, Missing); urinary bladder: 54.3478% (minimum 70%, Missing)",-0.411905,-0.487234,-0.64605,0,3,partial,43.1,18.5,16,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 3); thymus: 16 nTPM (manageable, limit 5); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); colon: 4 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); rectum: 3.7 nTPM (protected, limit 3); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105851,PIK3CG,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.5294% (minimum 75%, Missing); bone marrow: 10.3950% (minimum 75%, Missing); cerebral cortex: 73.5294% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 55.5556% (minimum 75%, Missing); liver: 72.4638% (minimum 75%, Missing); lung: 51.5464% (minimum 60%, Enhanced); lymph node: 21.2766% (minimum 70%, Missing); rectum: 57.4713% (minimum 70%, Missing); small intestine: 54.3478% (minimum 75%, Missing); spleen: 31.8471% (minimum 65%, Missing); stomach: 56.8182% (minimum 70%, Missing); thymus: 23.8095% (minimum 65%, Missing); urinary bladder: 54.3478% (minimum 70%, Missing)",-0.411905,-0.487234,-0.64605,0,3,partial,43.1,18.5,16,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 3); thymus: 16 nTPM (manageable, limit 5); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); colon: 4 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); rectum: 3.7 nTPM (protected, limit 3); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105851,PIK3CG,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 73.5294% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 10.3950% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.5294% (minimum 75%, Baseline (adaptation disabled)); colon: 55.5556% (minimum 70%, Baseline (adaptation disabled)); duodenum: 55.5556% (minimum 75%, Baseline (adaptation disabled)); liver: 72.4638% (minimum 75%, Baseline (adaptation disabled)); lung: 51.5464% (minimum 75%, Baseline (adaptation disabled)); lymph node: 21.2766% (minimum 70%, Baseline (adaptation disabled)); rectum: 57.4713% (minimum 70%, Baseline (adaptation disabled)); small intestine: 54.3478% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.7895% (minimum 75%, Baseline (adaptation disabled)); spleen: 31.8471% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.8182% (minimum 70%, Baseline (adaptation disabled)); thymus: 23.8095% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 54.3478% (minimum 70%, Baseline (adaptation disabled))",-0.411905,-0.487234,-0.64605,0,3,partial,43.1,18.5,16,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 3); thymus: 16 nTPM (manageable, limit 5); spleen: 10.7 nTPM (manageable, limit 5); lung: 4.7 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); colon: 4 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); rectum: 3.7 nTPM (protected, limit 3); smooth muscle: 2.6 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105851,PIK3CG,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.9130% (minimum 98%, Approved); amygdala: 96.2264% (minimum 99%, Missing); basal ganglia: 92.7273% (minimum 99%, Missing); choroid plexus: 42.1488% (minimum 99%, Missing); esophagus: 89.4737% (minimum 95%, Approved); heart muscle: 92.7273% (minimum 98%, Approved); hippocampal formation: 92.7273% (minimum 99%, Missing); hypothalamus: 94.4444% (minimum 99%, Missing); kidney: 96.2264% (minimum 98%, Approved); liver: 96.2264% (minimum 98%, Approved); lung: 82.2581% (minimum 98%, Approved); parathyroid gland: 6.8919% (minimum 95%, Approved); pituitary gland: 98.0769% (minimum 99%, Missing); skeletal muscle: 94.4444% (minimum 98%, Approved); skin: 87.9310% (minimum 90%, Approved); small intestine: 94.4444% (minimum 98%, Approved); spinal cord: 98.0769% (minimum 99%, Missing); thymus: 94.4444% (minimum 95%, Missing); thyroid gland: 83.6066% (minimum 90%, Approved)",-0.0639344,-0.881081,-0.568512,0,3,partial,7,68.9,1,"parathyroid gland: 68.9 nTPM (protected, limit 4); choroid plexus: 7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105877,DNAH11,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 42.1488% (minimum 75%, Missing); parathyroid gland: 6.8919% (minimum 65%, Approved)",0.236066,-0.581081,-0.328512,0,3,partial,7,68.9,1,"parathyroid gland: 68.9 nTPM (protected, limit 4); choroid plexus: 7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105877,DNAH11,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 42.1488% (minimum 75%, Missing); parathyroid gland: 6.8919% (minimum 65%, Approved)",0.236066,-0.581081,-0.328512,0,3,partial,7,68.9,1,"parathyroid gland: 68.9 nTPM (protected, limit 4); choroid plexus: 7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105877,DNAH11,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 42.1488% (minimum 75%, Missing); parathyroid gland: 6.8919% (minimum 65%, Approved)",0.236066,-0.581081,-0.328512,0,3,partial,7,68.9,1,"parathyroid gland: 68.9 nTPM (protected, limit 4); choroid plexus: 7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105877,DNAH11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.9130% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 42.1488% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 6.8919% (minimum 70%, Baseline (adaptation disabled))",0.186066,-0.631081,-0.328512,0,3,partial,7,68.9,1,"parathyroid gland: 68.9 nTPM (protected, limit 3); choroid plexus: 7 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105877,DNAH11,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.3399% (minimum 95%, Missing); adrenal gland: 71.4789% (minimum 99%, Missing); amygdala: 77.4809% (minimum 99%, Missing); basal ganglia: 76.0300% (minimum 99%, Missing); bone marrow: 36.9091% (minimum 99%, Missing); cerebellum: 68.8136% (minimum 99%, Missing); cerebral cortex: 61.8902% (minimum 99%, Missing); choroid plexus: 82.8571% (minimum 99%, Missing); colon: 64.8562% (minimum 97%, Missing); duodenum: 68.5811% (minimum 99%, Missing); esophagus: 66.7763% (minimum 97%, Missing); heart muscle: 67.2185% (minimum 99%, Missing); hippocampal formation: 76.6038% (minimum 99%, Missing); hypothalamus: 78.9883% (minimum 99%, Missing); kidney: 68.3502% (minimum 99%, Missing); liver: 66.3399% (minimum 99%, Missing); lung: 69.0476% (minimum 99%, Missing); lymph node: 58.0000% (minimum 97%, Missing); midbrain: 77.4809% (minimum 99%, Missing); pancreas: 66.9967% (minimum 99%, Missing); parathyroid gland: 62.2699% (minimum 97%, Missing); pituitary gland: 80.5556% (minimum 99%, Missing); rectum: 68.1208% (minimum 97%, Missing); retina: 59.3567% (minimum 99%, Missing); salivary gland: 70.7317% (minimum 97%, Missing); skeletal muscle: 41.0101% (minimum 99%, Missing); skin: 66.3399% (minimum 95%, Missing); small intestine: 67.2185% (minimum 99%, Missing); smooth muscle: 64.0379% (minimum 99%, Missing); spinal cord: 73.2852% (minimum 99%, Missing); spleen: 60.5970% (minimum 95%, Missing); stomach: 70.0000% (minimum 97%, Missing); thymus: 53.0026% (minimum 95%, Missing); thyroid gland: 61.3293% (minimum 95%, Missing); tongue: 52.8646% (minimum 97%, Missing); urinary bladder: 65.6958% (minimum 97%, Missing)",-0.419974,-0.441354,-0.620909,0,3,partial,34.7,18.1,18,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 2); retina: 13.9 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.8 nTPM (manageable, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 2); urinary bladder: 10.6 nTPM (protected, limit 2); liver: 10.3 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); adipose tissue: 10.3 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 2); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 2); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); salivary gland: 8.4 nTPM (protected, limit 2); adrenal gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105879,CBLL1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.4789% (minimum 75%, Missing); bone marrow: 36.9091% (minimum 75%, Missing); cerebellum: 68.8136% (minimum 75%, Missing); cerebral cortex: 61.8902% (minimum 75%, Missing); colon: 64.8562% (minimum 70%, Missing); duodenum: 68.5811% (minimum 75%, Missing); esophagus: 66.7763% (minimum 70%, Missing); heart muscle: 67.2185% (minimum 75%, Missing); kidney: 68.3502% (minimum 75%, Missing); liver: 66.3399% (minimum 75%, Missing); lung: 69.0476% (minimum 75%, Missing); lymph node: 58.0000% (minimum 70%, Missing); pancreas: 66.9967% (minimum 75%, Missing); parathyroid gland: 62.2699% (minimum 70%, Missing); rectum: 68.1208% (minimum 70%, Missing); retina: 59.3567% (minimum 75%, Missing); skeletal muscle: 41.0101% (minimum 75%, Missing); small intestine: 67.2185% (minimum 75%, Missing); smooth muscle: 64.0379% (minimum 75%, Missing); spinal cord: 73.2852% (minimum 75%, Missing); spleen: 60.5970% (minimum 65%, Missing); thymus: 53.0026% (minimum 65%, Missing); thyroid gland: 61.3293% (minimum 65%, Missing); tongue: 52.8646% (minimum 70%, Missing); urinary bladder: 65.6958% (minimum 70%, Missing)",-0.119974,-0.171354,-0.380909,0,3,partial,34.7,18.1,18,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 2); retina: 13.9 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.8 nTPM (manageable, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 2); urinary bladder: 10.6 nTPM (protected, limit 2); liver: 10.3 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); adipose tissue: 10.3 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 2); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 2); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); salivary gland: 8.4 nTPM (protected, limit 2); adrenal gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105879,CBLL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.4789% (minimum 75%, Missing); bone marrow: 36.9091% (minimum 75%, Missing); cerebellum: 68.8136% (minimum 75%, Missing); cerebral cortex: 61.8902% (minimum 75%, Missing); colon: 64.8562% (minimum 70%, Missing); duodenum: 68.5811% (minimum 75%, Missing); esophagus: 66.7763% (minimum 70%, Missing); heart muscle: 67.2185% (minimum 75%, Missing); kidney: 68.3502% (minimum 75%, Missing); liver: 66.3399% (minimum 75%, Missing); lung: 69.0476% (minimum 75%, Missing); lymph node: 58.0000% (minimum 70%, Missing); pancreas: 66.9967% (minimum 75%, Missing); parathyroid gland: 62.2699% (minimum 70%, Missing); rectum: 68.1208% (minimum 70%, Missing); retina: 59.3567% (minimum 75%, Missing); skeletal muscle: 41.0101% (minimum 75%, Missing); small intestine: 67.2185% (minimum 75%, Missing); smooth muscle: 64.0379% (minimum 75%, Missing); spinal cord: 73.2852% (minimum 75%, Missing); spleen: 60.5970% (minimum 65%, Missing); thymus: 53.0026% (minimum 65%, Missing); thyroid gland: 61.3293% (minimum 65%, Missing); tongue: 52.8646% (minimum 70%, Missing); urinary bladder: 65.6958% (minimum 70%, Missing)",-0.119974,-0.171354,-0.380909,0,3,partial,34.7,18.1,18,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 3); thymus: 18 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 3); retina: 13.9 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.8 nTPM (manageable, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 3); urinary bladder: 10.6 nTPM (protected, limit 3); liver: 10.3 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); adipose tissue: 10.3 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 3); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 3); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 3); salivary gland: 8.4 nTPM (protected, limit 3); adrenal gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105879,CBLL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.4789% (minimum 75%, Missing); bone marrow: 36.9091% (minimum 75%, Missing); cerebellum: 68.8136% (minimum 75%, Missing); cerebral cortex: 61.8902% (minimum 75%, Missing); colon: 64.8562% (minimum 70%, Missing); duodenum: 68.5811% (minimum 75%, Missing); esophagus: 66.7763% (minimum 70%, Missing); heart muscle: 67.2185% (minimum 75%, Missing); kidney: 68.3502% (minimum 75%, Missing); liver: 66.3399% (minimum 75%, Missing); lung: 69.0476% (minimum 75%, Missing); lymph node: 58.0000% (minimum 70%, Missing); pancreas: 66.9967% (minimum 75%, Missing); parathyroid gland: 62.2699% (minimum 70%, Missing); rectum: 68.1208% (minimum 70%, Missing); retina: 59.3567% (minimum 75%, Missing); skeletal muscle: 41.0101% (minimum 75%, Missing); small intestine: 67.2185% (minimum 75%, Missing); smooth muscle: 64.0379% (minimum 75%, Missing); spinal cord: 73.2852% (minimum 75%, Missing); spleen: 60.5970% (minimum 65%, Missing); thymus: 53.0026% (minimum 65%, Missing); thyroid gland: 61.3293% (minimum 65%, Missing); tongue: 52.8646% (minimum 70%, Missing); urinary bladder: 65.6958% (minimum 70%, Missing)",-0.119974,-0.171354,-0.380909,0,3,partial,34.7,18.1,18,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 3); thymus: 18 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 3); retina: 13.9 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.8 nTPM (manageable, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 3); urinary bladder: 10.6 nTPM (protected, limit 3); liver: 10.3 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); adipose tissue: 10.3 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 3); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 3); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 3); salivary gland: 8.4 nTPM (protected, limit 3); adrenal gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105879,CBLL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.4789% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 36.9091% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.8136% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.8902% (minimum 75%, Baseline (adaptation disabled)); colon: 64.8562% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.5811% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.7763% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 67.2185% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.3502% (minimum 75%, Baseline (adaptation disabled)); liver: 66.3399% (minimum 75%, Baseline (adaptation disabled)); lung: 69.0476% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 66.9967% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.2699% (minimum 70%, Baseline (adaptation disabled)); rectum: 68.1208% (minimum 70%, Baseline (adaptation disabled)); retina: 59.3567% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 41.0101% (minimum 75%, Baseline (adaptation disabled)); small intestine: 67.2185% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.0379% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.2852% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.5970% (minimum 65%, Baseline (adaptation disabled)); thymus: 53.0026% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 61.3293% (minimum 65%, Baseline (adaptation disabled)); tongue: 52.8646% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.6958% (minimum 70%, Baseline (adaptation disabled))",-0.119974,-0.171354,-0.380909,0,3,partial,34.7,18.1,18,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 3); thymus: 18 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 3); retina: 13.9 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.8 nTPM (manageable, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 3); urinary bladder: 10.6 nTPM (protected, limit 3); liver: 10.3 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); adipose tissue: 10.3 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 3); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 3); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 3); salivary gland: 8.4 nTPM (protected, limit 3); adrenal gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105879,CBLL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.9677% (minimum 95%, Missing); adrenal gland: 84.6154% (minimum 99%, Missing); amygdala: 59.4595% (minimum 99%, Missing); basal ganglia: 48.8889% (minimum 99%, Missing); cerebellum: 95.6522% (minimum 99%, Missing); cerebral cortex: 55.0000% (minimum 99%, Missing); choroid plexus: 28.5714% (minimum 99%, Missing); colon: 78.5714% (minimum 97%, Missing); duodenum: 95.6522% (minimum 99%, Missing); esophagus: 78.5714% (minimum 97%, Missing); heart muscle: 81.4815% (minimum 99%, Missing); hippocampal formation: 51.1628% (minimum 99%, Missing); hypothalamus: 64.7059% (minimum 99%, Missing); kidney: 91.6667% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 84.6154% (minimum 99%, Missing); lymph node: 57.8947% (minimum 97%, Missing); midbrain: 46.8085% (minimum 99%, Missing); pancreas: 88.0000% (minimum 99%, Missing); parathyroid gland: 95.6522% (minimum 97%, Missing); pituitary gland: 88.0000% (minimum 99%, Missing); rectum: 81.4815% (minimum 97%, Missing); retina: 88.0000% (minimum 99%, Missing); salivary gland: 84.6154% (minimum 97%, Missing); skeletal muscle: 64.7059% (minimum 99%, Missing); skin: 84.6154% (minimum 95%, Missing); small intestine: 88.0000% (minimum 99%, Missing); smooth muscle: 78.5714% (minimum 99%, Missing); spinal cord: 41.5094% (minimum 99%, Missing); spleen: 55.0000% (minimum 95%, Missing); stomach: 88.0000% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 91.6667% (minimum 95%, Missing); tongue: 78.5714% (minimum 97%, Missing); urinary bladder: 75.8621% (minimum 97%, Missing)",-0.4,-0.391053,-0.704286,0,80,unavailable,5.5,1.6,1.8,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105889,STEAP1B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 59.4595% (minimum 75%, Missing); basal ganglia: 48.8889% (minimum 75%, Missing); cerebral cortex: 55.0000% (minimum 75%, Missing); choroid plexus: 28.5714% (minimum 75%, Missing); hippocampal formation: 51.1628% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); lymph node: 57.8947% (minimum 70%, Missing); midbrain: 46.8085% (minimum 75%, Missing); skeletal muscle: 64.7059% (minimum 75%, Missing); spinal cord: 41.5094% (minimum 75%, Missing); spleen: 55.0000% (minimum 65%, Missing)",-0.1,-0.121053,-0.464286,0,80,unavailable,5.5,1.6,1.8,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105889,STEAP1B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 59.4595% (minimum 75%, Missing); basal ganglia: 48.8889% (minimum 75%, Missing); cerebral cortex: 55.0000% (minimum 75%, Missing); choroid plexus: 28.5714% (minimum 75%, Missing); hippocampal formation: 51.1628% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); lymph node: 57.8947% (minimum 70%, Missing); midbrain: 46.8085% (minimum 75%, Missing); skeletal muscle: 64.7059% (minimum 75%, Missing); spinal cord: 41.5094% (minimum 75%, Missing); spleen: 55.0000% (minimum 65%, Missing)",-0.1,-0.121053,-0.464286,0,80,unavailable,5.5,1.6,1.8,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105889,STEAP1B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 59.4595% (minimum 75%, Missing); basal ganglia: 48.8889% (minimum 75%, Missing); cerebral cortex: 55.0000% (minimum 75%, Missing); choroid plexus: 28.5714% (minimum 75%, Missing); hippocampal formation: 51.1628% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); lymph node: 57.8947% (minimum 70%, Missing); midbrain: 46.8085% (minimum 75%, Missing); skeletal muscle: 64.7059% (minimum 75%, Missing); spinal cord: 41.5094% (minimum 75%, Missing); spleen: 55.0000% (minimum 65%, Missing)",-0.1,-0.121053,-0.464286,0,80,unavailable,5.5,1.6,1.8,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105889,STEAP1B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 59.4595% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 48.8889% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 55.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 28.5714% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 51.1628% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.7059% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.8947% (minimum 70%, Baseline (adaptation disabled)); midbrain: 46.8085% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 64.7059% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 41.5094% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.0000% (minimum 65%, Baseline (adaptation disabled))",-0.1,-0.121053,-0.464286,0,80,unavailable,5.5,1.6,1.8,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105889,STEAP1B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 82.0359% (minimum 95%, Enhanced); amygdala: 90.7285% (minimum 99%, Missing); basal ganglia: 86.1635% (minimum 99%, Missing); bone marrow: 85.0932% (minimum 95%, Enhanced); cerebellum: 88.3871% (minimum 95%, Enhanced); cerebral cortex: 90.7285% (minimum 99%, Missing); choroid plexus: 55.2419% (minimum 99%, Missing); colon: 90.1316% (minimum 97%, Missing); duodenum: 95.1389% (minimum 99%, Missing); heart muscle: 90.1316% (minimum 95%, Enhanced); hippocampal formation: 88.9610% (minimum 99%, Missing); hypothalamus: 86.1635% (minimum 99%, Missing); kidney: 75.2747% (minimum 95%, Enhanced); liver: 92.5676% (minimum 95%, Enhanced); lung: 81.0651% (minimum 95%, Enhanced); midbrain: 92.5676% (minimum 99%, Missing); pancreas: 89.5425% (minimum 95%, Enhanced); parathyroid gland: 63.4259% (minimum 80%, Enhanced); pituitary gland: 79.1908% (minimum 99%, Missing); rectum: 89.5425% (minimum 97%, Missing); retina: 75.2747% (minimum 99%, Missing); skeletal muscle: 93.1973% (minimum 95%, Enhanced); small intestine: 93.1973% (minimum 99%, Missing); smooth muscle: 83.0303% (minimum 95%, Enhanced); spinal cord: 92.5676% (minimum 99%, Missing); thymus: 85.0932% (minimum 95%, Missing); tongue: 90.1316% (minimum 97%, Missing)",-0.0990683,-0.165741,-0.437581,0,12,partial,11.1,7.9,4.7,"choroid plexus: 11.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105948,IFT56,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 55.2419% (minimum 75%, Missing)",0.200932,0.0842593,-0.197581,0,12,partial,11.1,7.9,4.7,"choroid plexus: 11.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105948,IFT56,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 55.2419% (minimum 75%, Missing)",0.200932,0.0842593,-0.197581,0,12,partial,11.1,7.9,4.7,"choroid plexus: 11.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105948,IFT56,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 55.2419% (minimum 75%, Missing)",0.200932,0.0842593,-0.197581,0,12,partial,11.1,7.9,4.7,"choroid plexus: 11.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105948,IFT56,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 55.2419% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.4259% (minimum 70%, Baseline (adaptation disabled))",0.0945652,-0.0657407,-0.197581,0,12,partial,11.1,7.9,4.7,"choroid plexus: 11.1 nTPM (vital, limit 1); parathyroid gland: 7.9 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105948,IFT56,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.9350% (minimum 99%, Missing); basal ganglia: 95.9350% (minimum 99%, Missing); choroid plexus: 98.9933% (minimum 99%, Missing); colon: 96.8801% (minimum 97%, Missing); duodenum: 97.3597% (minimum 99%, Missing); hippocampal formation: 96.2480% (minimum 99%, Missing); hypothalamus: 96.2480% (minimum 99%, Missing); midbrain: 96.4052% (minimum 99%, Missing); pituitary gland: 97.3597% (minimum 99%, Missing); retina: 95.6240% (minimum 99%, Missing); small intestine: 97.8441% (minimum 99%, Missing); spinal cord: 94.5513% (minimum 99%, Missing)",0.0316972,-0.00119869,-0.0444872,0,9,partial,3.4,2.9,2.4,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105982,RNF32,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331697,0.268801,0.195513,0,9,partial,3.4,2.9,2.4,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105982,RNF32,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331697,0.268801,0.195513,0,9,partial,3.4,2.9,2.4,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105982,RNF32,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331697,0.268801,0.195513,0,9,partial,3.4,2.9,2.4,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105982,RNF32,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.310912,0.25315,0.195513,0,9,partial,3.4,2.9,2.4,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000105982,RNF32,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.0490426,0.0297605,0.00916218,0,80,unavailable,0.7,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106013,ANKRD7,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349043,0.29976,0.249162,0,80,unavailable,0.7,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106013,ANKRD7,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349043,0.29976,0.249162,0,80,unavailable,0.7,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106013,ANKRD7,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349043,0.29976,0.249162,0,80,unavailable,0.7,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106013,ANKRD7,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349043,0.29976,0.249162,0,80,unavailable,0.7,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106013,ANKRD7,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.4286% (minimum 90%, Approved); adrenal gland: 75.5102% (minimum 99%, Missing); amygdala: 87.4016% (minimum 99%, Missing); basal ganglia: 74.4966% (minimum 99%, Missing); bone marrow: 82.2222% (minimum 98%, Approved); cerebellum: 92.5000% (minimum 99%, Missing); cerebral cortex: 79.2857% (minimum 99%, Missing); choroid plexus: 48.4716% (minimum 99%, Missing); colon: 71.6129% (minimum 97%, Missing); duodenum: 89.5161% (minimum 99%, Missing); esophagus: 79.8561% (minimum 97%, Missing); heart muscle: 71.1538% (minimum 99%, Missing); hippocampal formation: 84.7328% (minimum 99%, Missing); hypothalamus: 81.0219% (minimum 99%, Missing); kidney: 69.8113% (minimum 99%, Missing); liver: 84.0909% (minimum 99%, Missing); lung: 54.6798% (minimum 99%, Missing); lymph node: 90.2439% (minimum 97%, Missing); midbrain: 82.8358% (minimum 99%, Missing); pancreas: 77.0833% (minimum 99%, Missing); parathyroid gland: 70.7006% (minimum 97%, Missing); pituitary gland: 67.2727% (minimum 99%, Missing); rectum: 84.7328% (minimum 97%, Missing); retina: 84.7328% (minimum 99%, Missing); salivary gland: 78.7234% (minimum 97%, Missing); skeletal muscle: 83.4586% (minimum 98%, Approved); skin: 78.1690% (minimum 95%, Missing); small intestine: 84.0909% (minimum 99%, Missing); smooth muscle: 66.0714% (minimum 98%, Approved); spinal cord: 90.9836% (minimum 99%, Missing); stomach: 78.1690% (minimum 97%, Missing); thymus: 90.9836% (minimum 95%, Missing); thyroid gland: 63.0682% (minimum 95%, Missing); tongue: 77.0833% (minimum 97%, Missing); urinary bladder: 72.5490% (minimum 97%, Missing)",-0.319318,-0.262994,-0.505284,0,2,partial,11.8,4.6,6.5,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (manageable, limit 5); smooth muscle: 5.7 nTPM (vital, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); cerebral cortex: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 2); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106125,MINDY4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 74.4966% (minimum 75%, Missing); choroid plexus: 48.4716% (minimum 75%, Missing); heart muscle: 71.1538% (minimum 75%, Missing); kidney: 69.8113% (minimum 75%, Missing); lung: 54.6798% (minimum 75%, Missing); pituitary gland: 67.2727% (minimum 75%, Missing); smooth muscle: 66.0714% (minimum 70%, Approved); thyroid gland: 63.0682% (minimum 65%, Missing)",-0.0193182,0.00700637,-0.265284,0,2,partial,11.8,4.6,6.5,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (manageable, limit 5); smooth muscle: 5.7 nTPM (vital, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); cerebral cortex: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 2); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106125,MINDY4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 74.4966% (minimum 75%, Missing); choroid plexus: 48.4716% (minimum 75%, Missing); heart muscle: 71.1538% (minimum 75%, Missing); kidney: 69.8113% (minimum 75%, Missing); lung: 54.6798% (minimum 75%, Missing); pituitary gland: 67.2727% (minimum 75%, Missing); smooth muscle: 66.0714% (minimum 70%, Approved); thyroid gland: 63.0682% (minimum 65%, Missing)",-0.0193182,0.00700637,-0.265284,0,2,partial,11.8,4.6,6.5,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (manageable, limit 5); smooth muscle: 5.7 nTPM (vital, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); urinary bladder: 4.2 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 2); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 2); small intestine: 2.1 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106125,MINDY4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 74.4966% (minimum 75%, Missing); choroid plexus: 48.4716% (minimum 75%, Missing); heart muscle: 71.1538% (minimum 75%, Missing); kidney: 69.8113% (minimum 75%, Missing); lung: 54.6798% (minimum 75%, Missing); pituitary gland: 67.2727% (minimum 75%, Missing); smooth muscle: 66.0714% (minimum 70%, Approved); thyroid gland: 63.0682% (minimum 65%, Missing)",-0.0193182,0.00700637,-0.265284,0,2,partial,11.8,4.6,6.5,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (manageable, limit 5); smooth muscle: 5.7 nTPM (vital, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); urinary bladder: 4.2 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 2); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 2); small intestine: 2.1 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106125,MINDY4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.4286% (minimum 65%, Baseline (adaptation disabled)); basal ganglia: 74.4966% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 48.4716% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.1538% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.8113% (minimum 75%, Baseline (adaptation disabled)); lung: 54.6798% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 67.2727% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.0714% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 63.0682% (minimum 65%, Baseline (adaptation disabled))",-0.0193182,0.00700637,-0.265284,0,2,partial,11.8,4.6,6.5,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (manageable, limit 5); adipose tissue: 6.4 nTPM (manageable, limit 5); smooth muscle: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); urinary bladder: 4.2 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106125,MINDY4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106304,SPAM1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106304,SPAM1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106304,SPAM1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106304,SPAM1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.226879,0,1,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106304,SPAM1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00896373,0,1,partial,0.5,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106328,FSCN3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248964,0,1,partial,0.5,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106328,FSCN3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248964,0,1,partial,0.5,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106328,FSCN3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248964,0,1,partial,0.5,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106328,FSCN3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346898,0.298964,0.24484,0,1,partial,0.5,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106328,FSCN3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 98.9975% (minimum 99%, Missing); retina: 98.7500% (minimum 99%, Missing)",0.0474747,0.0262169,-0.0025,0,3,partial,1,1.2,1.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106336,FBXO24,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.347475,0.296217,0.2375,0,3,partial,1,1.2,1.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106336,FBXO24,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.347475,0.296217,0.2375,0,3,partial,1,1.2,1.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106336,FBXO24,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.347475,0.296217,0.2375,0,3,partial,1,1.2,1.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106336,FBXO24,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.333811,0.285037,0.2375,0,3,partial,1,1.2,1.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106336,FBXO24,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106410,NOBOX,admission_only,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106410,NOBOX,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106410,NOBOX,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106410,NOBOX,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106410,NOBOX,current_fixed,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.7682% (minimum 95%, Uncertain); adrenal gland: 46.7797% (minimum 99%, Missing); amygdala: 60.2244% (minimum 99%, Missing); basal ganglia: 59.4096% (minimum 99%, Missing); bone marrow: 44.9093% (minimum 99%, Missing); cerebellum: 65.5360% (minimum 99%, Missing); cerebral cortex: 63.0548% (minimum 99%, Missing); choroid plexus: 48.0119% (minimum 99%, Missing); colon: 52.3861% (minimum 97%, Missing); duodenum: 48.8866% (minimum 99%, Missing); esophagus: 47.4693% (minimum 97%, Missing); heart muscle: 45.5660% (minimum 99%, Missing); hippocampal formation: 62.2423% (minimum 99%, Missing); hypothalamus: 61.7647% (minimum 99%, Missing); kidney: 45.9344% (minimum 99%, Missing); liver: 23.8224% (minimum 99%, Missing); lung: 53.6965% (minimum 99%, Missing); lymph node: 49.4371% (minimum 97%, Missing); midbrain: 57.2614% (minimum 99%, Missing); pancreas: 52.2445% (minimum 99%, Missing); parathyroid gland: 58.7234% (minimum 97%, Missing); pituitary gland: 60.8696% (minimum 99%, Missing); rectum: 53.5774% (minimum 97%, Missing); retina: 70.5109% (minimum 99%, Missing); salivary gland: 56.7234% (minimum 97%, Missing); skeletal muscle: 30.5599% (minimum 99%, Uncertain); skin: 53.4292% (minimum 95%, Missing); small intestine: 50.7087% (minimum 99%, Missing); smooth muscle: 59.9628% (minimum 99%, Uncertain); spinal cord: 55.0741% (minimum 99%, Missing); spleen: 51.2467% (minimum 95%, Missing); stomach: 48.7141% (minimum 97%, Missing); thymus: 41.9817% (minimum 95%, Missing); thyroid gland: 59.6296% (minimum 95%, Missing); tongue: 45.5660% (minimum 97%, Missing); urinary bladder: 52.0755% (minimum 97%, Missing)",-0.530183,-0.51434,-0.751776,0,3,partial,308.9,115.4,133.5,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); thymus: 133.5 nTPM (manageable, limit 5); bone marrow: 118.5 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 2); heart muscle: 115.4 nTPM (vital, limit 1); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 2); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 2); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 2); adipose tissue: 97.5 nTPM (manageable, limit 5); small intestine: 93.9 nTPM (vital, limit 1); spleen: 91.9 nTPM (manageable, limit 5); urinary bladder: 88.9 nTPM (protected, limit 2); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 2); skin: 84.2 nTPM (manageable, limit 5); rectum: 83.7 nTPM (protected, limit 2); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); salivary gland: 73.7 nTPM (protected, limit 2); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 2); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (manageable, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106588,PSMA2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.7682% (minimum 65%, Uncertain); adrenal gland: 46.7797% (minimum 75%, Missing); amygdala: 60.2244% (minimum 75%, Missing); basal ganglia: 59.4096% (minimum 75%, Missing); bone marrow: 44.9093% (minimum 75%, Missing); cerebellum: 65.5360% (minimum 75%, Missing); cerebral cortex: 63.0548% (minimum 75%, Missing); choroid plexus: 48.0119% (minimum 75%, Missing); colon: 52.3861% (minimum 70%, Missing); duodenum: 48.8866% (minimum 75%, Missing); esophagus: 47.4693% (minimum 70%, Missing); heart muscle: 45.5660% (minimum 75%, Missing); hippocampal formation: 62.2423% (minimum 75%, Missing); hypothalamus: 61.7647% (minimum 75%, Missing); kidney: 45.9344% (minimum 75%, Missing); liver: 23.8224% (minimum 75%, Missing); lung: 53.6965% (minimum 75%, Missing); lymph node: 49.4371% (minimum 70%, Missing); midbrain: 57.2614% (minimum 75%, Missing); pancreas: 52.2445% (minimum 75%, Missing); parathyroid gland: 58.7234% (minimum 70%, Missing); pituitary gland: 60.8696% (minimum 75%, Missing); rectum: 53.5774% (minimum 70%, Missing); retina: 70.5109% (minimum 75%, Missing); salivary gland: 56.7234% (minimum 70%, Missing); skeletal muscle: 30.5599% (minimum 75%, Uncertain); skin: 53.4292% (minimum 65%, Missing); small intestine: 50.7087% (minimum 75%, Missing); smooth muscle: 59.9628% (minimum 75%, Uncertain); spinal cord: 55.0741% (minimum 75%, Missing); spleen: 51.2467% (minimum 65%, Missing); stomach: 48.7141% (minimum 70%, Missing); thymus: 41.9817% (minimum 65%, Missing); thyroid gland: 59.6296% (minimum 65%, Missing); tongue: 45.5660% (minimum 70%, Missing); urinary bladder: 52.0755% (minimum 70%, Missing)",-0.230183,-0.24434,-0.511776,0,3,partial,308.9,115.4,133.5,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); thymus: 133.5 nTPM (manageable, limit 5); bone marrow: 118.5 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 2); heart muscle: 115.4 nTPM (vital, limit 1); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 2); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 2); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 2); adipose tissue: 97.5 nTPM (manageable, limit 5); small intestine: 93.9 nTPM (vital, limit 1); spleen: 91.9 nTPM (manageable, limit 5); urinary bladder: 88.9 nTPM (protected, limit 2); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 2); skin: 84.2 nTPM (manageable, limit 5); rectum: 83.7 nTPM (protected, limit 2); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); salivary gland: 73.7 nTPM (protected, limit 2); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 2); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (manageable, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106588,PSMA2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.7682% (minimum 65%, Uncertain); adrenal gland: 46.7797% (minimum 75%, Missing); amygdala: 60.2244% (minimum 75%, Missing); basal ganglia: 59.4096% (minimum 75%, Missing); bone marrow: 44.9093% (minimum 75%, Missing); cerebellum: 65.5360% (minimum 75%, Missing); cerebral cortex: 63.0548% (minimum 75%, Missing); choroid plexus: 48.0119% (minimum 75%, Missing); colon: 52.3861% (minimum 70%, Missing); duodenum: 48.8866% (minimum 75%, Missing); esophagus: 47.4693% (minimum 70%, Missing); heart muscle: 45.5660% (minimum 75%, Missing); hippocampal formation: 62.2423% (minimum 75%, Missing); hypothalamus: 61.7647% (minimum 75%, Missing); kidney: 45.9344% (minimum 75%, Missing); liver: 23.8224% (minimum 75%, Missing); lung: 53.6965% (minimum 75%, Missing); lymph node: 49.4371% (minimum 70%, Missing); midbrain: 57.2614% (minimum 75%, Missing); pancreas: 52.2445% (minimum 75%, Missing); parathyroid gland: 58.7234% (minimum 70%, Missing); pituitary gland: 60.8696% (minimum 75%, Missing); rectum: 53.5774% (minimum 70%, Missing); retina: 70.5109% (minimum 75%, Missing); salivary gland: 56.7234% (minimum 70%, Missing); skeletal muscle: 30.5599% (minimum 75%, Uncertain); skin: 53.4292% (minimum 65%, Missing); small intestine: 50.7087% (minimum 75%, Missing); smooth muscle: 59.9628% (minimum 75%, Uncertain); spinal cord: 55.0741% (minimum 75%, Missing); spleen: 51.2467% (minimum 65%, Missing); stomach: 48.7141% (minimum 70%, Missing); thymus: 41.9817% (minimum 65%, Missing); thyroid gland: 59.6296% (minimum 65%, Missing); tongue: 45.5660% (minimum 70%, Missing); urinary bladder: 52.0755% (minimum 70%, Missing)",-0.230183,-0.24434,-0.511776,0,3,partial,308.9,115.4,133.5,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); thymus: 133.5 nTPM (manageable, limit 5); bone marrow: 118.5 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 3); heart muscle: 115.4 nTPM (vital, limit 1); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 3); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 3); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 3); adipose tissue: 97.5 nTPM (manageable, limit 5); small intestine: 93.9 nTPM (vital, limit 1); spleen: 91.9 nTPM (manageable, limit 5); urinary bladder: 88.9 nTPM (protected, limit 3); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 3); skin: 84.2 nTPM (manageable, limit 5); rectum: 83.7 nTPM (protected, limit 3); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); salivary gland: 73.7 nTPM (protected, limit 3); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 3); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (manageable, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106588,PSMA2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.7682% (minimum 65%, Uncertain); adrenal gland: 46.7797% (minimum 75%, Missing); amygdala: 60.2244% (minimum 75%, Missing); basal ganglia: 59.4096% (minimum 75%, Missing); bone marrow: 44.9093% (minimum 75%, Missing); cerebellum: 65.5360% (minimum 75%, Missing); cerebral cortex: 63.0548% (minimum 75%, Missing); choroid plexus: 48.0119% (minimum 75%, Missing); colon: 52.3861% (minimum 70%, Missing); duodenum: 48.8866% (minimum 75%, Missing); esophagus: 47.4693% (minimum 70%, Missing); heart muscle: 45.5660% (minimum 75%, Missing); hippocampal formation: 62.2423% (minimum 75%, Missing); hypothalamus: 61.7647% (minimum 75%, Missing); kidney: 45.9344% (minimum 75%, Missing); liver: 23.8224% (minimum 75%, Missing); lung: 53.6965% (minimum 75%, Missing); lymph node: 49.4371% (minimum 70%, Missing); midbrain: 57.2614% (minimum 75%, Missing); pancreas: 52.2445% (minimum 75%, Missing); parathyroid gland: 58.7234% (minimum 70%, Missing); pituitary gland: 60.8696% (minimum 75%, Missing); rectum: 53.5774% (minimum 70%, Missing); retina: 70.5109% (minimum 75%, Missing); salivary gland: 56.7234% (minimum 70%, Missing); skeletal muscle: 30.5599% (minimum 75%, Uncertain); skin: 53.4292% (minimum 65%, Missing); small intestine: 50.7087% (minimum 75%, Missing); smooth muscle: 59.9628% (minimum 75%, Uncertain); spinal cord: 55.0741% (minimum 75%, Missing); spleen: 51.2467% (minimum 65%, Missing); stomach: 48.7141% (minimum 70%, Missing); thymus: 41.9817% (minimum 65%, Missing); thyroid gland: 59.6296% (minimum 65%, Missing); tongue: 45.5660% (minimum 70%, Missing); urinary bladder: 52.0755% (minimum 70%, Missing)",-0.230183,-0.24434,-0.511776,0,3,partial,308.9,115.4,133.5,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); thymus: 133.5 nTPM (manageable, limit 5); bone marrow: 118.5 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 3); heart muscle: 115.4 nTPM (vital, limit 1); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 3); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 3); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 3); adipose tissue: 97.5 nTPM (manageable, limit 5); small intestine: 93.9 nTPM (vital, limit 1); spleen: 91.9 nTPM (manageable, limit 5); urinary bladder: 88.9 nTPM (protected, limit 3); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 3); skin: 84.2 nTPM (manageable, limit 5); rectum: 83.7 nTPM (protected, limit 3); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); salivary gland: 73.7 nTPM (protected, limit 3); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 3); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (manageable, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106588,PSMA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.7682% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 46.7797% (minimum 75%, Baseline (adaptation disabled)); amygdala: 60.2244% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 59.4096% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 44.9093% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.5360% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.0548% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 48.0119% (minimum 75%, Baseline (adaptation disabled)); colon: 52.3861% (minimum 70%, Baseline (adaptation disabled)); duodenum: 48.8866% (minimum 75%, Baseline (adaptation disabled)); esophagus: 47.4693% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 45.5660% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 62.2423% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.7647% (minimum 75%, Baseline (adaptation disabled)); kidney: 45.9344% (minimum 75%, Baseline (adaptation disabled)); liver: 23.8224% (minimum 75%, Baseline (adaptation disabled)); lung: 53.6965% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.4371% (minimum 70%, Baseline (adaptation disabled)); midbrain: 57.2614% (minimum 75%, Baseline (adaptation disabled)); pancreas: 52.2445% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.7234% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 60.8696% (minimum 75%, Baseline (adaptation disabled)); rectum: 53.5774% (minimum 70%, Baseline (adaptation disabled)); retina: 70.5109% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.7234% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 30.5599% (minimum 75%, Baseline (adaptation disabled)); skin: 53.4292% (minimum 65%, Baseline (adaptation disabled)); small intestine: 50.7087% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.9628% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 55.0741% (minimum 75%, Baseline (adaptation disabled)); spleen: 51.2467% (minimum 65%, Baseline (adaptation disabled)); stomach: 48.7141% (minimum 70%, Baseline (adaptation disabled)); thymus: 41.9817% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 59.6296% (minimum 65%, Baseline (adaptation disabled)); tongue: 45.5660% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.0755% (minimum 70%, Baseline (adaptation disabled))",-0.230183,-0.24434,-0.511776,0,3,partial,308.9,115.4,133.5,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); thymus: 133.5 nTPM (manageable, limit 5); bone marrow: 118.5 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 3); heart muscle: 115.4 nTPM (vital, limit 1); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 3); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 3); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 3); adipose tissue: 97.5 nTPM (manageable, limit 5); small intestine: 93.9 nTPM (vital, limit 1); spleen: 91.9 nTPM (manageable, limit 5); urinary bladder: 88.9 nTPM (protected, limit 3); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 3); skin: 84.2 nTPM (manageable, limit 5); rectum: 83.7 nTPM (protected, limit 3); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); salivary gland: 73.7 nTPM (protected, limit 3); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 3); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (manageable, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106588,PSMA2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 81.7391% (minimum 95%, Missing); adrenal gland: 71.4829% (minimum 99%, Missing); amygdala: 92.6108% (minimum 99%, Missing); basal ganglia: 93.0693% (minimum 99%, Missing); bone marrow: 93.5323% (minimum 99%, Missing); cerebellum: 95.4315% (minimum 99%, Missing); cerebral cortex: 94.0000% (minimum 99%, Missing); choroid plexus: 90.3846% (minimum 99%, Missing); colon: 82.4561% (minimum 97%, Missing); duodenum: 92.1569% (minimum 99%, Missing); esophagus: 80.3419% (minimum 97%, Missing); heart muscle: 85.4545% (minimum 99%, Missing); hippocampal formation: 93.0693% (minimum 99%, Missing); hypothalamus: 93.5323% (minimum 99%, Missing); kidney: 83.5556% (minimum 99%, Missing); liver: 80.6867% (minimum 99%, Missing); lung: 82.4561% (minimum 99%, Missing); lymph node: 93.0693% (minimum 97%, Missing); midbrain: 92.6108% (minimum 99%, Missing); pancreas: 54.8105% (minimum 99%, Missing); parathyroid gland: 89.5238% (minimum 97%, Missing); pituitary gland: 86.6359% (minimum 99%, Missing); rectum: 91.7073% (minimum 97%, Missing); retina: 94.4724% (minimum 99%, Missing); salivary gland: 78.0083% (minimum 97%, Missing); skeletal muscle: 92.6108% (minimum 99%, Missing); skin: 80.6867% (minimum 95%, Missing); small intestine: 82.8194% (minimum 99%, Missing); smooth muscle: 93.5323% (minimum 99%, Missing); spinal cord: 93.0693% (minimum 99%, Missing); spleen: 86.2385% (minimum 95%, Missing); stomach: 75.8065% (minimum 97%, Missing); thyroid gland: 81.3853% (minimum 95%, Missing); tongue: 96.9072% (minimum 97%, Missing); urinary bladder: 86.2385% (minimum 97%, Missing)",-0.143133,-0.211935,-0.441895,0,80,unavailable,15.5,6,4.5,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); salivary gland: 5.3 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); liver: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106638,TBL2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4829% (minimum 75%, Missing); pancreas: 54.8105% (minimum 75%, Missing)",0.156867,0.0580645,-0.201895,0,80,unavailable,15.5,6,4.5,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); salivary gland: 5.3 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); liver: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106638,TBL2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4829% (minimum 75%, Missing); pancreas: 54.8105% (minimum 75%, Missing)",0.156867,0.0580645,-0.201895,0,80,unavailable,15.5,6,4.5,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); salivary gland: 5.3 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); liver: 4.5 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106638,TBL2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4829% (minimum 75%, Missing); pancreas: 54.8105% (minimum 75%, Missing)",0.156867,0.0580645,-0.201895,0,80,unavailable,15.5,6,4.5,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); salivary gland: 5.3 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); liver: 4.5 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106638,TBL2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4829% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.8105% (minimum 75%, Baseline (adaptation disabled))",0.156867,0.0580645,-0.201895,0,80,unavailable,15.5,6,4.5,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); salivary gland: 5.3 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); liver: 4.5 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106638,TBL2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 92.1053% (minimum 99%, Missing); basal ganglia: 95.4545% (minimum 99%, Missing); cerebral cortex: 88.2353% (minimum 99%, Missing); hippocampal formation: 93.7500% (minimum 99%, Missing)",0.05,0.03,-0.107647,0,2,partial,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106648,GALNTL5,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.132353,0,2,partial,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106648,GALNTL5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.132353,0,2,partial,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106648,GALNTL5,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.132353,0,2,partial,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106648,GALNTL5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.132353,0,2,partial,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106648,GALNTL5,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.5966% (minimum 95%, Missing); adrenal gland: 86.6608% (minimum 99%, Missing); amygdala: 89.9175% (minimum 99%, Missing); basal ganglia: 78.8585% (minimum 99%, Missing); bone marrow: 59.0253% (minimum 99%, Missing); cerebellum: 81.2759% (minimum 99%, Missing); cerebral cortex: 86.1282% (minimum 99%, Missing); choroid plexus: 82.1608% (minimum 99%, Missing); colon: 91.0864% (minimum 97%, Missing); duodenum: 93.3397% (minimum 99%, Missing); esophagus: 86.4317% (minimum 97%, Missing); heart muscle: 93.2510% (minimum 99%, Missing); hippocampal formation: 86.2039% (minimum 99%, Missing); hypothalamus: 88.2194% (minimum 99%, Missing); kidney: 93.8756% (minimum 99%, Missing); liver: 94.5998% (minimum 99%, Missing); lung: 89.0200% (minimum 99%, Missing); lymph node: 86.4317% (minimum 97%, Missing); midbrain: 86.5843% (minimum 99%, Missing); pancreas: 94.1459% (minimum 99%, Missing); parathyroid gland: 90.5817% (minimum 97%, Missing); pituitary gland: 80.6743% (minimum 99%, Missing); rectum: 90.6654% (minimum 97%, Missing); retina: 80.1471% (minimum 99%, Missing); salivary gland: 91.0019% (minimum 97%, Missing); skeletal muscle: 81.4784% (minimum 99%, Missing); skin: 83.4894% (minimum 95%, Missing); small intestine: 89.9175% (minimum 99%, Missing); smooth muscle: 87.6676% (minimum 99%, Missing); spinal cord: 76.5808% (minimum 99%, Missing); spleen: 84.4961% (minimum 95%, Missing); stomach: 88.2988% (minimum 97%, Missing); thymus: 78.6058% (minimum 95%, Missing); thyroid gland: 90.8333% (minimum 95%, Missing); tongue: 90.3315% (minimum 97%, Missing); urinary bladder: 84.7882% (minimum 97%, Missing)",-0.163942,-0.122118,-0.399747,0,80,unavailable,68.1,17.6,26.7,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); thymus: 26.7 nTPM (manageable, limit 5); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); skin: 19.4 nTPM (manageable, limit 5); spleen: 18 nTPM (manageable, limit 5); urinary bladder: 17.6 nTPM (protected, limit 2); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 2); esophagus: 15.4 nTPM (protected, limit 2); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 2); parathyroid gland: 10.2 nTPM (protected, limit 2); rectum: 10.1 nTPM (protected, limit 2); thyroid gland: 9.9 nTPM (manageable, limit 5); salivary gland: 9.7 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106829,TLE4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 59.0253% (minimum 75%, Missing)",0.136058,0.147882,-0.159747,0,80,unavailable,68.1,17.6,26.7,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); thymus: 26.7 nTPM (manageable, limit 5); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); skin: 19.4 nTPM (manageable, limit 5); spleen: 18 nTPM (manageable, limit 5); urinary bladder: 17.6 nTPM (protected, limit 2); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 2); esophagus: 15.4 nTPM (protected, limit 2); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 2); parathyroid gland: 10.2 nTPM (protected, limit 2); rectum: 10.1 nTPM (protected, limit 2); thyroid gland: 9.9 nTPM (manageable, limit 5); salivary gland: 9.7 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106829,TLE4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 59.0253% (minimum 75%, Missing)",0.136058,0.147882,-0.159747,0,80,unavailable,68.1,17.6,26.7,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); thymus: 26.7 nTPM (manageable, limit 5); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); skin: 19.4 nTPM (manageable, limit 5); spleen: 18 nTPM (manageable, limit 5); urinary bladder: 17.6 nTPM (protected, limit 3); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 3); esophagus: 15.4 nTPM (protected, limit 3); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 3); parathyroid gland: 10.2 nTPM (protected, limit 3); rectum: 10.1 nTPM (protected, limit 3); thyroid gland: 9.9 nTPM (manageable, limit 5); salivary gland: 9.7 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106829,TLE4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 59.0253% (minimum 75%, Missing)",0.136058,0.147882,-0.159747,0,80,unavailable,68.1,17.6,26.7,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); thymus: 26.7 nTPM (manageable, limit 5); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); skin: 19.4 nTPM (manageable, limit 5); spleen: 18 nTPM (manageable, limit 5); urinary bladder: 17.6 nTPM (protected, limit 3); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 3); esophagus: 15.4 nTPM (protected, limit 3); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 3); parathyroid gland: 10.2 nTPM (protected, limit 3); rectum: 10.1 nTPM (protected, limit 3); thyroid gland: 9.9 nTPM (manageable, limit 5); salivary gland: 9.7 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106829,TLE4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 59.0253% (minimum 75%, Baseline (adaptation disabled))",0.136058,0.147882,-0.159747,0,80,unavailable,68.1,17.6,26.7,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); thymus: 26.7 nTPM (manageable, limit 5); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); skin: 19.4 nTPM (manageable, limit 5); spleen: 18 nTPM (manageable, limit 5); urinary bladder: 17.6 nTPM (protected, limit 3); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 3); esophagus: 15.4 nTPM (protected, limit 3); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 3); parathyroid gland: 10.2 nTPM (protected, limit 3); rectum: 10.1 nTPM (protected, limit 3); thyroid gland: 9.9 nTPM (manageable, limit 5); salivary gland: 9.7 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000106829,TLE4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7619% (minimum 80%, Supported); adrenal gland: 66.3462% (minimum 99%, Missing); amygdala: 82.1429% (minimum 99%, Missing); basal ganglia: 78.8571% (minimum 99%, Missing); bone marrow: 51.3011% (minimum 99%, Missing); cerebellum: 67.3171% (minimum 99%, Missing); cerebral cortex: 72.2513% (minimum 99%, Missing); choroid plexus: 79.3103% (minimum 99%, Missing); colon: 63.0137% (minimum 97%, Missing); duodenum: 58.7234% (minimum 99%, Missing); esophagus: 55.6452% (minimum 97%, Missing); heart muscle: 67.3171% (minimum 99%, Missing); hippocampal formation: 80.7018% (minimum 99%, Missing); hypothalamus: 83.1325% (minimum 99%, Missing); kidney: 65.7143% (minimum 99%, Missing); liver: 58.9744% (minimum 99%, Missing); lung: 58.4746% (minimum 99%, Missing); lymph node: 44.9511% (minimum 97%, Missing); midbrain: 81.6568% (minimum 99%, Missing); pancreas: 57.5000% (minimum 99%, Missing); parathyroid gland: 61.6071% (minimum 97%, Missing); pituitary gland: 74.5946% (minimum 99%, Missing); rectum: 60.2620% (minimum 97%, Missing); retina: 65.7143% (minimum 99%, Missing); salivary gland: 55.6452% (minimum 97%, Missing); skeletal muscle: 44.8052% (minimum 99%, Missing); skin: 51.3011% (minimum 95%, Missing); small intestine: 60.2620% (minimum 99%, Missing); smooth muscle: 51.8797% (minimum 99%, Missing); spinal cord: 77.0950% (minimum 99%, Missing); spleen: 54.5455% (minimum 95%, Missing); stomach: 64.1860% (minimum 97%, Missing); thymus: 48.9362% (minimum 95%, Missing); thyroid gland: 55.8704% (minimum 95%, Missing); tongue: 47.7509% (minimum 97%, Missing); urinary bladder: 56.5574% (minimum 97%, Missing)",-0.460638,-0.520489,-0.541948,0,7,partial,17,16.9,14.4,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 2); tongue: 15.1 nTPM (protected, limit 2); thymus: 14.4 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skin: 13.1 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); spleen: 11.5 nTPM (manageable, limit 5); salivary gland: 11 nTPM (protected, limit 2); esophagus: 11 nTPM (protected, limit 2); thyroid gland: 10.9 nTPM (manageable, limit 5); urinary bladder: 10.6 nTPM (protected, limit 2); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 2); parathyroid gland: 8.6 nTPM (protected, limit 2); colon: 8.1 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); kidney: 7.2 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107036,RIC1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7619% (minimum 55%, Supported); adrenal gland: 66.3462% (minimum 75%, Missing); bone marrow: 51.3011% (minimum 75%, Missing); cerebellum: 67.3171% (minimum 75%, Missing); cerebral cortex: 72.2513% (minimum 75%, Missing); colon: 63.0137% (minimum 70%, Missing); duodenum: 58.7234% (minimum 75%, Missing); esophagus: 55.6452% (minimum 70%, Missing); heart muscle: 67.3171% (minimum 75%, Missing); kidney: 65.7143% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Missing); lung: 58.4746% (minimum 75%, Missing); lymph node: 44.9511% (minimum 70%, Missing); pancreas: 57.5000% (minimum 75%, Missing); parathyroid gland: 61.6071% (minimum 70%, Missing); pituitary gland: 74.5946% (minimum 75%, Missing); rectum: 60.2620% (minimum 70%, Missing); retina: 65.7143% (minimum 75%, Missing); salivary gland: 55.6452% (minimum 70%, Missing); skeletal muscle: 44.8052% (minimum 75%, Missing); skin: 51.3011% (minimum 65%, Missing); small intestine: 60.2620% (minimum 75%, Missing); smooth muscle: 51.8797% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 64.1860% (minimum 70%, Missing); thymus: 48.9362% (minimum 65%, Missing); thyroid gland: 55.8704% (minimum 65%, Missing); tongue: 47.7509% (minimum 70%, Missing); urinary bladder: 56.5574% (minimum 70%, Missing)",-0.160638,-0.250489,-0.301948,0,7,partial,17,16.9,14.4,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 2); tongue: 15.1 nTPM (protected, limit 2); thymus: 14.4 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skin: 13.1 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); spleen: 11.5 nTPM (manageable, limit 5); salivary gland: 11 nTPM (protected, limit 2); esophagus: 11 nTPM (protected, limit 2); thyroid gland: 10.9 nTPM (manageable, limit 5); urinary bladder: 10.6 nTPM (protected, limit 2); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 2); parathyroid gland: 8.6 nTPM (protected, limit 2); colon: 8.1 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); kidney: 7.2 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107036,RIC1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7619% (minimum 55%, Supported); adrenal gland: 66.3462% (minimum 75%, Missing); bone marrow: 51.3011% (minimum 75%, Missing); cerebellum: 67.3171% (minimum 75%, Missing); cerebral cortex: 72.2513% (minimum 75%, Missing); colon: 63.0137% (minimum 70%, Missing); duodenum: 58.7234% (minimum 75%, Missing); esophagus: 55.6452% (minimum 70%, Missing); heart muscle: 67.3171% (minimum 75%, Missing); kidney: 65.7143% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Missing); lung: 58.4746% (minimum 75%, Missing); lymph node: 44.9511% (minimum 70%, Missing); pancreas: 57.5000% (minimum 75%, Missing); parathyroid gland: 61.6071% (minimum 70%, Missing); pituitary gland: 74.5946% (minimum 75%, Missing); rectum: 60.2620% (minimum 70%, Missing); retina: 65.7143% (minimum 75%, Missing); salivary gland: 55.6452% (minimum 70%, Missing); skeletal muscle: 44.8052% (minimum 75%, Missing); skin: 51.3011% (minimum 65%, Missing); small intestine: 60.2620% (minimum 75%, Missing); smooth muscle: 51.8797% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 64.1860% (minimum 70%, Missing); thymus: 48.9362% (minimum 65%, Missing); thyroid gland: 55.8704% (minimum 65%, Missing); tongue: 47.7509% (minimum 70%, Missing); urinary bladder: 56.5574% (minimum 70%, Missing)",-0.160638,-0.250489,-0.301948,0,7,partial,17,16.9,14.4,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 3); tongue: 15.1 nTPM (protected, limit 3); thymus: 14.4 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skin: 13.1 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); spleen: 11.5 nTPM (manageable, limit 5); salivary gland: 11 nTPM (protected, limit 3); esophagus: 11 nTPM (protected, limit 3); thyroid gland: 10.9 nTPM (manageable, limit 5); urinary bladder: 10.6 nTPM (protected, limit 3); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 3); parathyroid gland: 8.6 nTPM (protected, limit 3); colon: 8.1 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); kidney: 7.2 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107036,RIC1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7619% (minimum 55%, Supported); adrenal gland: 66.3462% (minimum 75%, Missing); bone marrow: 51.3011% (minimum 75%, Missing); cerebellum: 67.3171% (minimum 75%, Missing); cerebral cortex: 72.2513% (minimum 75%, Missing); colon: 63.0137% (minimum 70%, Missing); duodenum: 58.7234% (minimum 75%, Missing); esophagus: 55.6452% (minimum 70%, Missing); heart muscle: 67.3171% (minimum 75%, Missing); kidney: 65.7143% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Missing); lung: 58.4746% (minimum 75%, Missing); lymph node: 44.9511% (minimum 70%, Missing); pancreas: 57.5000% (minimum 75%, Missing); parathyroid gland: 61.6071% (minimum 70%, Missing); pituitary gland: 74.5946% (minimum 75%, Missing); rectum: 60.2620% (minimum 70%, Missing); retina: 65.7143% (minimum 75%, Missing); salivary gland: 55.6452% (minimum 70%, Missing); skeletal muscle: 44.8052% (minimum 75%, Missing); skin: 51.3011% (minimum 65%, Missing); small intestine: 60.2620% (minimum 75%, Missing); smooth muscle: 51.8797% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 64.1860% (minimum 70%, Missing); thymus: 48.9362% (minimum 65%, Missing); thyroid gland: 55.8704% (minimum 65%, Missing); tongue: 47.7509% (minimum 70%, Missing); urinary bladder: 56.5574% (minimum 70%, Missing)",-0.160638,-0.250489,-0.301948,0,7,partial,17,16.9,14.4,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 3); tongue: 15.1 nTPM (protected, limit 3); thymus: 14.4 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skin: 13.1 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); spleen: 11.5 nTPM (manageable, limit 5); salivary gland: 11 nTPM (protected, limit 3); esophagus: 11 nTPM (protected, limit 3); thyroid gland: 10.9 nTPM (manageable, limit 5); urinary bladder: 10.6 nTPM (protected, limit 3); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 3); parathyroid gland: 8.6 nTPM (protected, limit 3); colon: 8.1 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); kidney: 7.2 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107036,RIC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7619% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 66.3462% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 51.3011% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.3171% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.2513% (minimum 75%, Baseline (adaptation disabled)); colon: 63.0137% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.7234% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.6452% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 67.3171% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.7143% (minimum 75%, Baseline (adaptation disabled)); liver: 58.9744% (minimum 75%, Baseline (adaptation disabled)); lung: 58.4746% (minimum 75%, Baseline (adaptation disabled)); lymph node: 44.9511% (minimum 70%, Baseline (adaptation disabled)); pancreas: 57.5000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.6071% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 74.5946% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.2620% (minimum 70%, Baseline (adaptation disabled)); retina: 65.7143% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.6452% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 44.8052% (minimum 75%, Baseline (adaptation disabled)); skin: 51.3011% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.2620% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 51.8797% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.5455% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.1860% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.9362% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.8704% (minimum 65%, Baseline (adaptation disabled)); tongue: 47.7509% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.5574% (minimum 70%, Baseline (adaptation disabled))",-0.160638,-0.250489,-0.301948,0,7,partial,17,16.9,14.4,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 3); tongue: 15.1 nTPM (protected, limit 3); thymus: 14.4 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skin: 13.1 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); spleen: 11.5 nTPM (manageable, limit 5); adipose tissue: 11.4 nTPM (manageable, limit 5); esophagus: 11 nTPM (protected, limit 3); salivary gland: 11 nTPM (protected, limit 3); thyroid gland: 10.9 nTPM (manageable, limit 5); urinary bladder: 10.6 nTPM (protected, limit 3); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 3); parathyroid gland: 8.6 nTPM (protected, limit 3); colon: 8.1 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); retina: 7.2 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107036,RIC1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 95%, Missing); adrenal gland: 55.5024% (minimum 99%, Missing); amygdala: 63.0435% (minimum 99%, Missing); basal ganglia: 60.4167% (minimum 99%, Missing); bone marrow: 28.0872% (minimum 99%, Missing); cerebellum: 23.2465% (minimum 99%, Missing); cerebral cortex: 60.4167% (minimum 99%, Missing); choroid plexus: 41.5771% (minimum 99%, Missing); colon: 46.5863% (minimum 97%, Missing); duodenum: 47.7366% (minimum 99%, Missing); esophagus: 53.9535% (minimum 97%, Missing); heart muscle: 60.7330% (minimum 99%, Missing); hippocampal formation: 59.1837% (minimum 99%, Missing); hypothalamus: 57.7114% (minimum 99%, Missing); kidney: 58.0000% (minimum 99%, Missing); liver: 52.0179% (minimum 99%, Missing); lung: 52.9680% (minimum 99%, Missing); lymph node: 38.2838% (minimum 97%, Missing); midbrain: 61.7021% (minimum 99%, Missing); pancreas: 42.6471% (minimum 99%, Missing); parathyroid gland: 40.2778% (minimum 97%, Missing); pituitary gland: 50.2165% (minimum 99%, Missing); rectum: 42.6471% (minimum 97%, Missing); retina: 29.2929% (minimum 99%, Missing); salivary gland: 50.6550% (minimum 97%, Missing); skeletal muscle: 59.1837% (minimum 99%, Missing); skin: 44.1065% (minimum 95%, Missing); small intestine: 45.3125% (minimum 99%, Missing); smooth muscle: 52.7273% (minimum 99%, Missing); spinal cord: 54.7170% (minimum 99%, Missing); spleen: 46.2151% (minimum 95%, Missing); stomach: 44.1065% (minimum 97%, Missing); thymus: 33.5260% (minimum 95%, Missing); thyroid gland: 47.1545% (minimum 95%, Missing); tongue: 66.6667% (minimum 97%, Missing); urinary bladder: 53.9535% (minimum 97%, Missing)",-0.61474,-0.587162,-0.757535,0,80,unavailable,38.3,18.7,23,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); thymus: 23 nTPM (manageable, limit 5); lymph node: 18.7 nTPM (protected, limit 2); parathyroid gland: 17.2 nTPM (protected, limit 2); choroid plexus: 16.3 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 2); pancreas: 15.6 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 2); skin: 14.7 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); spleen: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 2); thyroid gland: 13 nTPM (manageable, limit 5); duodenum: 12.7 nTPM (vital, limit 1); pituitary gland: 11.5 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 2); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); urinary bladder: 9.9 nTPM (protected, limit 2); adipose tissue: 9.7 nTPM (manageable, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107077,KDM4C,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 65%, Missing); adrenal gland: 55.5024% (minimum 75%, Missing); amygdala: 63.0435% (minimum 75%, Missing); basal ganglia: 60.4167% (minimum 75%, Missing); bone marrow: 28.0872% (minimum 75%, Missing); cerebellum: 23.2465% (minimum 75%, Missing); cerebral cortex: 60.4167% (minimum 75%, Missing); choroid plexus: 41.5771% (minimum 75%, Missing); colon: 46.5863% (minimum 70%, Missing); duodenum: 47.7366% (minimum 75%, Missing); esophagus: 53.9535% (minimum 70%, Missing); heart muscle: 60.7330% (minimum 75%, Missing); hippocampal formation: 59.1837% (minimum 75%, Missing); hypothalamus: 57.7114% (minimum 75%, Missing); kidney: 58.0000% (minimum 75%, Missing); liver: 52.0179% (minimum 75%, Missing); lung: 52.9680% (minimum 75%, Missing); lymph node: 38.2838% (minimum 70%, Missing); midbrain: 61.7021% (minimum 75%, Missing); pancreas: 42.6471% (minimum 75%, Missing); parathyroid gland: 40.2778% (minimum 70%, Missing); pituitary gland: 50.2165% (minimum 75%, Missing); rectum: 42.6471% (minimum 70%, Missing); retina: 29.2929% (minimum 75%, Missing); salivary gland: 50.6550% (minimum 70%, Missing); skeletal muscle: 59.1837% (minimum 75%, Missing); skin: 44.1065% (minimum 65%, Missing); small intestine: 45.3125% (minimum 75%, Missing); smooth muscle: 52.7273% (minimum 75%, Missing); spinal cord: 54.7170% (minimum 75%, Missing); spleen: 46.2151% (minimum 65%, Missing); stomach: 44.1065% (minimum 70%, Missing); thymus: 33.5260% (minimum 65%, Missing); thyroid gland: 47.1545% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 53.9535% (minimum 70%, Missing)",-0.31474,-0.317162,-0.517535,0,80,unavailable,38.3,18.7,23,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); thymus: 23 nTPM (manageable, limit 5); lymph node: 18.7 nTPM (protected, limit 2); parathyroid gland: 17.2 nTPM (protected, limit 2); choroid plexus: 16.3 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 2); pancreas: 15.6 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 2); skin: 14.7 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); spleen: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 2); thyroid gland: 13 nTPM (manageable, limit 5); duodenum: 12.7 nTPM (vital, limit 1); pituitary gland: 11.5 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 2); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); urinary bladder: 9.9 nTPM (protected, limit 2); adipose tissue: 9.7 nTPM (manageable, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107077,KDM4C,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 65%, Missing); adrenal gland: 55.5024% (minimum 75%, Missing); amygdala: 63.0435% (minimum 75%, Missing); basal ganglia: 60.4167% (minimum 75%, Missing); bone marrow: 28.0872% (minimum 75%, Missing); cerebellum: 23.2465% (minimum 75%, Missing); cerebral cortex: 60.4167% (minimum 75%, Missing); choroid plexus: 41.5771% (minimum 75%, Missing); colon: 46.5863% (minimum 70%, Missing); duodenum: 47.7366% (minimum 75%, Missing); esophagus: 53.9535% (minimum 70%, Missing); heart muscle: 60.7330% (minimum 75%, Missing); hippocampal formation: 59.1837% (minimum 75%, Missing); hypothalamus: 57.7114% (minimum 75%, Missing); kidney: 58.0000% (minimum 75%, Missing); liver: 52.0179% (minimum 75%, Missing); lung: 52.9680% (minimum 75%, Missing); lymph node: 38.2838% (minimum 70%, Missing); midbrain: 61.7021% (minimum 75%, Missing); pancreas: 42.6471% (minimum 75%, Missing); parathyroid gland: 40.2778% (minimum 70%, Missing); pituitary gland: 50.2165% (minimum 75%, Missing); rectum: 42.6471% (minimum 70%, Missing); retina: 29.2929% (minimum 75%, Missing); salivary gland: 50.6550% (minimum 70%, Missing); skeletal muscle: 59.1837% (minimum 75%, Missing); skin: 44.1065% (minimum 65%, Missing); small intestine: 45.3125% (minimum 75%, Missing); smooth muscle: 52.7273% (minimum 75%, Missing); spinal cord: 54.7170% (minimum 75%, Missing); spleen: 46.2151% (minimum 65%, Missing); stomach: 44.1065% (minimum 70%, Missing); thymus: 33.5260% (minimum 65%, Missing); thyroid gland: 47.1545% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 53.9535% (minimum 70%, Missing)",-0.31474,-0.317162,-0.517535,0,80,unavailable,38.3,18.7,23,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); thymus: 23 nTPM (manageable, limit 5); lymph node: 18.7 nTPM (protected, limit 3); parathyroid gland: 17.2 nTPM (protected, limit 3); choroid plexus: 16.3 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 3); pancreas: 15.6 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 3); skin: 14.7 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); spleen: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 3); thyroid gland: 13 nTPM (manageable, limit 5); duodenum: 12.7 nTPM (vital, limit 1); pituitary gland: 11.5 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 3); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); urinary bladder: 9.9 nTPM (protected, limit 3); adipose tissue: 9.7 nTPM (manageable, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107077,KDM4C,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 65%, Missing); adrenal gland: 55.5024% (minimum 75%, Missing); amygdala: 63.0435% (minimum 75%, Missing); basal ganglia: 60.4167% (minimum 75%, Missing); bone marrow: 28.0872% (minimum 75%, Missing); cerebellum: 23.2465% (minimum 75%, Missing); cerebral cortex: 60.4167% (minimum 75%, Missing); choroid plexus: 41.5771% (minimum 75%, Missing); colon: 46.5863% (minimum 70%, Missing); duodenum: 47.7366% (minimum 75%, Missing); esophagus: 53.9535% (minimum 70%, Missing); heart muscle: 60.7330% (minimum 75%, Missing); hippocampal formation: 59.1837% (minimum 75%, Missing); hypothalamus: 57.7114% (minimum 75%, Missing); kidney: 58.0000% (minimum 75%, Missing); liver: 52.0179% (minimum 75%, Missing); lung: 52.9680% (minimum 75%, Missing); lymph node: 38.2838% (minimum 70%, Missing); midbrain: 61.7021% (minimum 75%, Missing); pancreas: 42.6471% (minimum 75%, Missing); parathyroid gland: 40.2778% (minimum 70%, Missing); pituitary gland: 50.2165% (minimum 75%, Missing); rectum: 42.6471% (minimum 70%, Missing); retina: 29.2929% (minimum 75%, Missing); salivary gland: 50.6550% (minimum 70%, Missing); skeletal muscle: 59.1837% (minimum 75%, Missing); skin: 44.1065% (minimum 65%, Missing); small intestine: 45.3125% (minimum 75%, Missing); smooth muscle: 52.7273% (minimum 75%, Missing); spinal cord: 54.7170% (minimum 75%, Missing); spleen: 46.2151% (minimum 65%, Missing); stomach: 44.1065% (minimum 70%, Missing); thymus: 33.5260% (minimum 65%, Missing); thyroid gland: 47.1545% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 53.9535% (minimum 70%, Missing)",-0.31474,-0.317162,-0.517535,0,80,unavailable,38.3,18.7,23,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); thymus: 23 nTPM (manageable, limit 5); lymph node: 18.7 nTPM (protected, limit 3); parathyroid gland: 17.2 nTPM (protected, limit 3); choroid plexus: 16.3 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 3); pancreas: 15.6 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 3); skin: 14.7 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); spleen: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 3); thyroid gland: 13 nTPM (manageable, limit 5); duodenum: 12.7 nTPM (vital, limit 1); pituitary gland: 11.5 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 3); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); urinary bladder: 9.9 nTPM (protected, limit 3); adipose tissue: 9.7 nTPM (manageable, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107077,KDM4C,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 55.5024% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.0435% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.4167% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 28.0872% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 23.2465% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.4167% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 41.5771% (minimum 75%, Baseline (adaptation disabled)); colon: 46.5863% (minimum 70%, Baseline (adaptation disabled)); duodenum: 47.7366% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.9535% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.7330% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 59.1837% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 57.7114% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 52.0179% (minimum 75%, Baseline (adaptation disabled)); lung: 52.9680% (minimum 75%, Baseline (adaptation disabled)); lymph node: 38.2838% (minimum 70%, Baseline (adaptation disabled)); midbrain: 61.7021% (minimum 75%, Baseline (adaptation disabled)); pancreas: 42.6471% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 40.2778% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 50.2165% (minimum 75%, Baseline (adaptation disabled)); rectum: 42.6471% (minimum 70%, Baseline (adaptation disabled)); retina: 29.2929% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.6550% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 59.1837% (minimum 75%, Baseline (adaptation disabled)); skin: 44.1065% (minimum 65%, Baseline (adaptation disabled)); small intestine: 45.3125% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 52.7273% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 54.7170% (minimum 75%, Baseline (adaptation disabled)); spleen: 46.2151% (minimum 65%, Baseline (adaptation disabled)); stomach: 44.1065% (minimum 70%, Baseline (adaptation disabled)); thymus: 33.5260% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 47.1545% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 53.9535% (minimum 70%, Baseline (adaptation disabled))",-0.31474,-0.317162,-0.517535,0,80,unavailable,38.3,18.7,23,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); thymus: 23 nTPM (manageable, limit 5); lymph node: 18.7 nTPM (protected, limit 3); parathyroid gland: 17.2 nTPM (protected, limit 3); choroid plexus: 16.3 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 3); pancreas: 15.6 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 3); skin: 14.7 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); spleen: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 3); thyroid gland: 13 nTPM (manageable, limit 5); duodenum: 12.7 nTPM (vital, limit 1); pituitary gland: 11.5 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 3); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); urinary bladder: 9.9 nTPM (protected, limit 3); adipose tissue: 9.7 nTPM (manageable, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107077,KDM4C,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 83.6000% (minimum 99%, Missing); basal ganglia: 89.8925% (minimum 99%, Missing); cerebellum: 76.2774% (minimum 99%, Missing); cerebral cortex: 63.3333% (minimum 99%, Missing); hippocampal formation: 84.1046% (minimum 99%, Missing); hypothalamus: 66.2441% (minimum 99%, Missing); kidney: 98.8180% (minimum 99%, Missing); midbrain: 70.8475% (minimum 99%, Missing); pituitary gland: 97.6636% (minimum 99%, Missing); retina: 89.6996% (minimum 99%, Missing); spinal cord: 93.7220% (minimum 99%, Missing)",0.05,0.0181797,-0.356667,0,7,partial,24.2,0.5,0.5,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107105,ELAVL2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 63.3333% (minimum 75%, Missing); hypothalamus: 66.2441% (minimum 75%, Missing); midbrain: 70.8475% (minimum 75%, Missing)",0.35,0.28818,-0.116667,0,7,partial,24.2,0.5,0.5,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107105,ELAVL2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 63.3333% (minimum 75%, Missing); hypothalamus: 66.2441% (minimum 75%, Missing); midbrain: 70.8475% (minimum 75%, Missing)",0.35,0.28818,-0.116667,0,7,partial,24.2,0.5,0.5,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107105,ELAVL2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 63.3333% (minimum 75%, Missing); hypothalamus: 66.2441% (minimum 75%, Missing); midbrain: 70.8475% (minimum 75%, Missing)",0.35,0.28818,-0.116667,0,7,partial,24.2,0.5,0.5,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107105,ELAVL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 63.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.2441% (minimum 75%, Baseline (adaptation disabled)); midbrain: 70.8475% (minimum 75%, Baseline (adaptation disabled))",0.33818,0.28818,-0.116667,0,7,partial,24.2,0.5,0.5,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107105,ELAVL2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.6154% (minimum 95%, Missing); adrenal gland: 54.1850% (minimum 99%, Missing); amygdala: 66.1290% (minimum 99%, Missing); basal ganglia: 71.0983% (minimum 99%, Missing); cerebellum: 90.4412% (minimum 99%, Missing); cerebral cortex: 38.8013% (minimum 99%, Missing); choroid plexus: 72.3529% (minimum 99%, Missing); colon: 84.2466% (minimum 97%, Missing); duodenum: 97.6190% (minimum 99%, Missing); esophagus: 96.0938% (minimum 97%, Missing); heart muscle: 87.2340% (minimum 99%, Missing); hippocampal formation: 64.3979% (minimum 99%, Missing); hypothalamus: 75.4601% (minimum 99%, Missing); kidney: 82.0000% (minimum 99%, Missing); liver: 89.1304% (minimum 99%, Missing); lymph node: 96.8504% (minimum 97%, Missing); midbrain: 83.6735% (minimum 99%, Missing); pancreas: 90.4412% (minimum 99%, Missing); parathyroid gland: 85.4167% (minimum 97%, Missing); pituitary gland: 68.7151% (minimum 99%, Missing); retina: 66.8478% (minimum 99%, Missing); salivary gland: 93.1818% (minimum 97%, Missing); skeletal muscle: 82.0000% (minimum 99%, Missing); small intestine: 93.8931% (minimum 99%, Missing); smooth muscle: 68.7151% (minimum 99%, Missing); spinal cord: 89.1304% (minimum 99%, Missing); stomach: 96.8504% (minimum 97%, Missing); thyroid gland: 93.1818% (minimum 95%, Missing); urinary bladder: 95.3488% (minimum 97%, Missing)",-0.0181818,-0.127534,-0.601987,0,80,unavailable,19.4,2.3,0.9,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); parathyroid gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107518,ATRNL1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 54.1850% (minimum 75%, Missing); amygdala: 66.1290% (minimum 75%, Missing); basal ganglia: 71.0983% (minimum 75%, Missing); cerebral cortex: 38.8013% (minimum 75%, Missing); choroid plexus: 72.3529% (minimum 75%, Missing); hippocampal formation: 64.3979% (minimum 75%, Missing); pituitary gland: 68.7151% (minimum 75%, Missing); retina: 66.8478% (minimum 75%, Missing); smooth muscle: 68.7151% (minimum 75%, Missing)",0.281818,0.142466,-0.361987,0,80,unavailable,19.4,2.3,0.9,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); parathyroid gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107518,ATRNL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 54.1850% (minimum 75%, Missing); amygdala: 66.1290% (minimum 75%, Missing); basal ganglia: 71.0983% (minimum 75%, Missing); cerebral cortex: 38.8013% (minimum 75%, Missing); choroid plexus: 72.3529% (minimum 75%, Missing); hippocampal formation: 64.3979% (minimum 75%, Missing); pituitary gland: 68.7151% (minimum 75%, Missing); retina: 66.8478% (minimum 75%, Missing); smooth muscle: 68.7151% (minimum 75%, Missing)",0.281818,0.142466,-0.361987,0,80,unavailable,19.4,2.3,0.9,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107518,ATRNL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 54.1850% (minimum 75%, Missing); amygdala: 66.1290% (minimum 75%, Missing); basal ganglia: 71.0983% (minimum 75%, Missing); cerebral cortex: 38.8013% (minimum 75%, Missing); choroid plexus: 72.3529% (minimum 75%, Missing); hippocampal formation: 64.3979% (minimum 75%, Missing); pituitary gland: 68.7151% (minimum 75%, Missing); retina: 66.8478% (minimum 75%, Missing); smooth muscle: 68.7151% (minimum 75%, Missing)",0.281818,0.142466,-0.361987,0,80,unavailable,19.4,2.3,0.9,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107518,ATRNL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 54.1850% (minimum 75%, Baseline (adaptation disabled)); amygdala: 66.1290% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.0983% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 38.8013% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.3529% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.3979% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 68.7151% (minimum 75%, Baseline (adaptation disabled)); retina: 66.8478% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.7151% (minimum 75%, Baseline (adaptation disabled))",0.281818,0.142466,-0.361987,0,80,unavailable,19.4,2.3,0.9,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107518,ATRNL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.5806% (minimum 90%, Approved); adrenal gland: 76.2712% (minimum 99%, Missing); amygdala: 81.8182% (minimum 99%, Missing); basal ganglia: 78.9474% (minimum 99%, Missing); bone marrow: 76.2712% (minimum 99%, Missing); cerebellum: 76.2712% (minimum 99%, Missing); cerebral cortex: 83.3333% (minimum 99%, Missing); choroid plexus: 77.5862% (minimum 99%, Missing); colon: 80.3571% (minimum 97%, Missing); duodenum: 84.9057% (minimum 99%, Missing); esophagus: 80.3571% (minimum 97%, Missing); heart muscle: 77.5862% (minimum 99%, Missing); hippocampal formation: 80.3571% (minimum 99%, Missing); hypothalamus: 80.3571% (minimum 99%, Missing); kidney: 69.2308% (minimum 99%, Missing); liver: 86.5385% (minimum 99%, Missing); lung: 76.2712% (minimum 99%, Missing); lymph node: 68.1818% (minimum 97%, Missing); midbrain: 81.8182% (minimum 99%, Missing); pancreas: 76.2712% (minimum 99%, Missing); parathyroid gland: 64.2857% (minimum 97%, Missing); pituitary gland: 77.5862% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 44.5545% (minimum 99%, Missing); salivary gland: 76.2712% (minimum 97%, Missing); skeletal muscle: 78.9474% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 77.5862% (minimum 99%, Missing); smooth muscle: 80.3571% (minimum 99%, Missing); spinal cord: 77.5862% (minimum 99%, Missing); spleen: 77.5862% (minimum 95%, Missing); stomach: 75.0000% (minimum 97%, Missing); thymus: 58.4416% (minimum 95%, Missing); thyroid gland: 55.5556% (minimum 95%, Missing); tongue: 95.7447% (minimum 97%, Missing); urinary bladder: 81.8182% (minimum 97%, Missing)",-0.394444,-0.327143,-0.544455,0,1,partial,5.6,2.5,3.6,"retina: 5.6 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107614,TRDMT1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 69.2308% (minimum 75%, Missing); lymph node: 68.1818% (minimum 70%, Missing); parathyroid gland: 64.2857% (minimum 70%, Missing); retina: 44.5545% (minimum 75%, Missing); thymus: 58.4416% (minimum 65%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing)",-0.0944444,-0.0571429,-0.304455,0,1,partial,5.6,2.5,3.6,"retina: 5.6 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107614,TRDMT1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 69.2308% (minimum 75%, Missing); lymph node: 68.1818% (minimum 70%, Missing); parathyroid gland: 64.2857% (minimum 70%, Missing); retina: 44.5545% (minimum 75%, Missing); thymus: 58.4416% (minimum 65%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing)",-0.0944444,-0.0571429,-0.304455,0,1,partial,5.6,2.5,3.6,"retina: 5.6 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107614,TRDMT1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 69.2308% (minimum 75%, Missing); lymph node: 68.1818% (minimum 70%, Missing); parathyroid gland: 64.2857% (minimum 70%, Missing); retina: 44.5545% (minimum 75%, Missing); thymus: 58.4416% (minimum 65%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing)",-0.0944444,-0.0571429,-0.304455,0,1,partial,5.6,2.5,3.6,"retina: 5.6 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107614,TRDMT1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 69.2308% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.1818% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 64.2857% (minimum 70%, Baseline (adaptation disabled)); retina: 44.5545% (minimum 75%, Baseline (adaptation disabled)); thymus: 58.4416% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.5556% (minimum 65%, Baseline (adaptation disabled))",-0.0944444,-0.0571429,-0.304455,0,1,partial,5.6,2.5,3.6,"retina: 5.6 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000107614,TRDMT1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.0527% (minimum 98%, Approved); amygdala: 80.8298% (minimum 99%, Missing); basal ganglia: 83.4146% (minimum 99%, Missing); bone marrow: 57.3826% (minimum 98%, Approved); cerebellum: 85.5951% (minimum 98%, Approved); cerebral cortex: 80.8723% (minimum 98%, Approved); choroid plexus: 88.8055% (minimum 99%, Missing); colon: 89.5809% (minimum 97%, Missing); duodenum: 93.3293% (minimum 98%, Approved); esophagus: 81.0427% (minimum 95%, Approved); heart muscle: 86.5093% (minimum 98%, Approved); hippocampal formation: 80.7027% (minimum 99%, Missing); hypothalamus: 81.0000% (minimum 99%, Missing); kidney: 92.3770% (minimum 98%, Approved); liver: 93.2162% (minimum 98%, Approved); lung: 90.7429% (minimum 98%, Approved); lymph node: 81.5580% (minimum 97%, Missing); midbrain: 84.9807% (minimum 99%, Missing); pancreas: 95.3532% (minimum 98%, Approved); pituitary gland: 84.5604% (minimum 99%, Missing); rectum: 94.4751% (minimum 95%, Approved); retina: 94.4172% (minimum 99%, Missing); salivary gland: 92.9348% (minimum 95%, Approved); skeletal muscle: 91.1730% (minimum 98%, Approved); small intestine: 90.7429% (minimum 98%, Approved); smooth muscle: 91.3895% (minimum 98%, Approved); spinal cord: 81.7313% (minimum 99%, Missing); spleen: 85.9777% (minimum 90%, Approved); stomach: 90.0000% (minimum 95%, Approved); thymus: 76.7964% (minimum 95%, Missing); tongue: 96.6102% (minimum 97%, Missing); urinary bladder: 90.7429% (minimum 97%, Missing)",-0.182036,-0.15442,-0.406174,0,0,routine_complete,114.3,36,46.5,"bone marrow: 114.3 nTPM (vital, limit 2); thymus: 46.5 nTPM (manageable, limit 5); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 2); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 4); lymph node: 34.8 nTPM (protected, limit 2); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 2); spleen: 25.1 nTPM (manageable, limit 10); heart muscle: 24 nTPM (vital, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 2); stomach: 17.1 nTPM (protected, limit 4); adrenal gland: 17 nTPM (vital, limit 2); small intestine: 15.7 nTPM (vital, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 10); lung: 15.7 nTPM (vital, limit 2); urinary bladder: 15.7 nTPM (protected, limit 2); skeletal muscle: 14.9 nTPM (vital, limit 2); smooth muscle: 14.5 nTPM (vital, limit 2); kidney: 12.7 nTPM (vital, limit 2); salivary gland: 11.7 nTPM (protected, limit 4); skin: 11.6 nTPM (manageable, limit 10); liver: 11.2 nTPM (vital, limit 2); duodenum: 11 nTPM (vital, limit 2); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 4); pancreas: 7.5 nTPM (vital, limit 2); parathyroid gland: 6.5 nTPM (protected, limit 4); tongue: 5.4 nTPM (protected, limit 2)",colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108106,UBE2S,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 57.3826% (minimum 70%, Approved)",0.117964,0.11558,-0.126174,0,0,routine_complete,114.3,36,46.5,"bone marrow: 114.3 nTPM (vital, limit 2); thymus: 46.5 nTPM (manageable, limit 5); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 2); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 4); lymph node: 34.8 nTPM (protected, limit 2); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 2); spleen: 25.1 nTPM (manageable, limit 10); heart muscle: 24 nTPM (vital, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 2); stomach: 17.1 nTPM (protected, limit 4); adrenal gland: 17 nTPM (vital, limit 2); small intestine: 15.7 nTPM (vital, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 10); lung: 15.7 nTPM (vital, limit 2); urinary bladder: 15.7 nTPM (protected, limit 2); skeletal muscle: 14.9 nTPM (vital, limit 2); smooth muscle: 14.5 nTPM (vital, limit 2); kidney: 12.7 nTPM (vital, limit 2); salivary gland: 11.7 nTPM (protected, limit 4); skin: 11.6 nTPM (manageable, limit 10); liver: 11.2 nTPM (vital, limit 2); duodenum: 11 nTPM (vital, limit 2); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 4); pancreas: 7.5 nTPM (vital, limit 2); parathyroid gland: 6.5 nTPM (protected, limit 4); tongue: 5.4 nTPM (protected, limit 2)",colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108106,UBE2S,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 57.3826% (minimum 70%, Approved)",0.117964,0.11558,-0.126174,0,0,routine_complete,114.3,36,46.5,"bone marrow: 114.3 nTPM (vital, limit 2); thymus: 46.5 nTPM (manageable, limit 5); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 2); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 4); lymph node: 34.8 nTPM (protected, limit 3); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 2); spleen: 25.1 nTPM (manageable, limit 10); heart muscle: 24 nTPM (vital, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 3); stomach: 17.1 nTPM (protected, limit 4); adrenal gland: 17 nTPM (vital, limit 2); small intestine: 15.7 nTPM (vital, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 10); lung: 15.7 nTPM (vital, limit 2); urinary bladder: 15.7 nTPM (protected, limit 3); skeletal muscle: 14.9 nTPM (vital, limit 2); smooth muscle: 14.5 nTPM (vital, limit 2); kidney: 12.7 nTPM (vital, limit 2); salivary gland: 11.7 nTPM (protected, limit 4); skin: 11.6 nTPM (manageable, limit 10); liver: 11.2 nTPM (vital, limit 2); duodenum: 11 nTPM (vital, limit 2); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 4); pancreas: 7.5 nTPM (vital, limit 2); parathyroid gland: 6.5 nTPM (protected, limit 4); tongue: 5.4 nTPM (protected, limit 3)",colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108106,UBE2S,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 57.3826% (minimum 70%, Approved)",0.117964,0.11558,-0.126174,0,0,routine_complete,114.3,36,46.5,"bone marrow: 114.3 nTPM (vital, limit 2); thymus: 46.5 nTPM (manageable, limit 5); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 2); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 4); lymph node: 34.8 nTPM (protected, limit 3); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 2); spleen: 25.1 nTPM (manageable, limit 10); heart muscle: 24 nTPM (vital, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 3); stomach: 17.1 nTPM (protected, limit 4); adrenal gland: 17 nTPM (vital, limit 2); small intestine: 15.7 nTPM (vital, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 10); lung: 15.7 nTPM (vital, limit 2); urinary bladder: 15.7 nTPM (protected, limit 3); skeletal muscle: 14.9 nTPM (vital, limit 2); smooth muscle: 14.5 nTPM (vital, limit 2); kidney: 12.7 nTPM (vital, limit 2); salivary gland: 11.7 nTPM (protected, limit 4); skin: 11.6 nTPM (manageable, limit 10); liver: 11.2 nTPM (vital, limit 2); duodenum: 11 nTPM (vital, limit 2); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 4); pancreas: 7.5 nTPM (vital, limit 2); parathyroid gland: 6.5 nTPM (protected, limit 4); tongue: 5.4 nTPM (protected, limit 3)",colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108106,UBE2S,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 57.3826% (minimum 75%, Baseline (adaptation disabled))",0.117964,0.110427,-0.176174,0,0,routine_complete,114.3,36,46.5,"bone marrow: 114.3 nTPM (vital, limit 1); thymus: 46.5 nTPM (manageable, limit 5); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 1); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 3); lymph node: 34.8 nTPM (protected, limit 3); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 1); spleen: 25.1 nTPM (manageable, limit 5); heart muscle: 24 nTPM (vital, limit 1); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 3); stomach: 17.1 nTPM (protected, limit 3); adrenal gland: 17 nTPM (vital, limit 1); small intestine: 15.7 nTPM (vital, limit 1); adipose tissue: 15.7 nTPM (manageable, limit 5); lung: 15.7 nTPM (vital, limit 1); urinary bladder: 15.7 nTPM (protected, limit 3); skeletal muscle: 14.9 nTPM (vital, limit 1); smooth muscle: 14.5 nTPM (vital, limit 1); kidney: 12.7 nTPM (vital, limit 1); salivary gland: 11.7 nTPM (protected, limit 3); skin: 11.6 nTPM (manageable, limit 5); liver: 11.2 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 3); pancreas: 7.5 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 3); tongue: 5.4 nTPM (protected, limit 3)",colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108106,UBE2S,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 76.5766% (minimum 90%, Approved); adrenal gland: 62.3472% (minimum 99%, Missing); amygdala: 72.4432% (minimum 99%, Missing); basal ganglia: 71.0306% (minimum 99%, Missing); bone marrow: 77.2727% (minimum 99%, Missing); cerebellum: 62.0438% (minimum 99%, Missing); cerebral cortex: 62.5000% (minimum 99%, Missing); choroid plexus: 57.6923% (minimum 99%, Missing); colon: 69.2935% (minimum 97%, Missing); duodenum: 66.4062% (minimum 99%, Missing); esophagus: 75.0000% (minimum 97%, Missing); heart muscle: 57.6923% (minimum 98%, Approved); hippocampal formation: 71.8310% (minimum 99%, Missing); hypothalamus: 66.9291% (minimum 99%, Missing); kidney: 55.4348% (minimum 99%, Missing); liver: 64.5570% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 66.9291% (minimum 97%, Missing); midbrain: 69.4823% (minimum 99%, Missing); pancreas: 66.7539% (minimum 99%, Missing); parathyroid gland: 48.6641% (minimum 97%, Missing); pituitary gland: 66.0622% (minimum 99%, Missing); rectum: 67.6393% (minimum 97%, Missing); retina: 50.0982% (minimum 99%, Missing); salivary gland: 68.1818% (minimum 97%, Missing); skeletal muscle: 60.1415% (minimum 99%, Missing); skin: 78.4615% (minimum 95%, Missing); small intestine: 70.8333% (minimum 99%, Missing); smooth muscle: 71.8310% (minimum 99%, Missing); spinal cord: 71.2291% (minimum 99%, Missing); spleen: 73.2759% (minimum 95%, Missing); stomach: 66.9291% (minimum 97%, Missing); thymus: 62.0438% (minimum 95%, Missing); thyroid gland: 65.2174% (minimum 95%, Missing); tongue: 65.0510% (minimum 97%, Missing); urinary bladder: 73.2759% (minimum 97%, Missing)",-0.329562,-0.483359,-0.489018,0,7,partial,25.4,26.9,15.6,"parathyroid gland: 26.9 nTPM (protected, limit 2); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); choroid plexus: 18.7 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 2); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 2); thyroid gland: 13.6 nTPM (manageable, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 2); lymph node: 12.6 nTPM (protected, limit 2); hypothalamus: 12.6 nTPM (vital, limit 1); rectum: 12.2 nTPM (protected, limit 2); salivary gland: 11.9 nTPM (protected, limit 2); colon: 11.3 nTPM (protected, limit 2); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); spleen: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 2); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); bone marrow: 7.5 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108666,C17orf75,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 62.3472% (minimum 75%, Missing); amygdala: 72.4432% (minimum 75%, Missing); basal ganglia: 71.0306% (minimum 75%, Missing); cerebellum: 62.0438% (minimum 75%, Missing); cerebral cortex: 62.5000% (minimum 75%, Missing); choroid plexus: 57.6923% (minimum 75%, Missing); colon: 69.2935% (minimum 70%, Missing); duodenum: 66.4062% (minimum 75%, Missing); heart muscle: 57.6923% (minimum 70%, Approved); hippocampal formation: 71.8310% (minimum 75%, Missing); hypothalamus: 66.9291% (minimum 75%, Missing); kidney: 55.4348% (minimum 75%, Missing); liver: 64.5570% (minimum 75%, Missing); lymph node: 66.9291% (minimum 70%, Missing); midbrain: 69.4823% (minimum 75%, Missing); pancreas: 66.7539% (minimum 75%, Missing); parathyroid gland: 48.6641% (minimum 70%, Missing); pituitary gland: 66.0622% (minimum 75%, Missing); rectum: 67.6393% (minimum 70%, Missing); retina: 50.0982% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 60.1415% (minimum 75%, Missing); small intestine: 70.8333% (minimum 75%, Missing); smooth muscle: 71.8310% (minimum 75%, Missing); spinal cord: 71.2291% (minimum 75%, Missing); stomach: 66.9291% (minimum 70%, Missing); thymus: 62.0438% (minimum 65%, Missing); tongue: 65.0510% (minimum 70%, Missing)",-0.029562,-0.213359,-0.249018,0,7,partial,25.4,26.9,15.6,"parathyroid gland: 26.9 nTPM (protected, limit 2); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); choroid plexus: 18.7 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 2); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 2); thyroid gland: 13.6 nTPM (manageable, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 2); lymph node: 12.6 nTPM (protected, limit 2); hypothalamus: 12.6 nTPM (vital, limit 1); rectum: 12.2 nTPM (protected, limit 2); salivary gland: 11.9 nTPM (protected, limit 2); colon: 11.3 nTPM (protected, limit 2); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); spleen: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 2); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); bone marrow: 7.5 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108666,C17orf75,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 62.3472% (minimum 75%, Missing); amygdala: 72.4432% (minimum 75%, Missing); basal ganglia: 71.0306% (minimum 75%, Missing); cerebellum: 62.0438% (minimum 75%, Missing); cerebral cortex: 62.5000% (minimum 75%, Missing); choroid plexus: 57.6923% (minimum 75%, Missing); colon: 69.2935% (minimum 70%, Missing); duodenum: 66.4062% (minimum 75%, Missing); heart muscle: 57.6923% (minimum 70%, Approved); hippocampal formation: 71.8310% (minimum 75%, Missing); hypothalamus: 66.9291% (minimum 75%, Missing); kidney: 55.4348% (minimum 75%, Missing); liver: 64.5570% (minimum 75%, Missing); lymph node: 66.9291% (minimum 70%, Missing); midbrain: 69.4823% (minimum 75%, Missing); pancreas: 66.7539% (minimum 75%, Missing); parathyroid gland: 48.6641% (minimum 70%, Missing); pituitary gland: 66.0622% (minimum 75%, Missing); rectum: 67.6393% (minimum 70%, Missing); retina: 50.0982% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 60.1415% (minimum 75%, Missing); small intestine: 70.8333% (minimum 75%, Missing); smooth muscle: 71.8310% (minimum 75%, Missing); spinal cord: 71.2291% (minimum 75%, Missing); stomach: 66.9291% (minimum 70%, Missing); thymus: 62.0438% (minimum 65%, Missing); tongue: 65.0510% (minimum 70%, Missing)",-0.029562,-0.213359,-0.249018,0,7,partial,25.4,26.9,15.6,"parathyroid gland: 26.9 nTPM (protected, limit 3); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); choroid plexus: 18.7 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 2); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 3); thyroid gland: 13.6 nTPM (manageable, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 3); lymph node: 12.6 nTPM (protected, limit 3); hypothalamus: 12.6 nTPM (vital, limit 1); rectum: 12.2 nTPM (protected, limit 3); salivary gland: 11.9 nTPM (protected, limit 3); colon: 11.3 nTPM (protected, limit 3); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); spleen: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 3); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); bone marrow: 7.5 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108666,C17orf75,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 62.3472% (minimum 75%, Missing); amygdala: 72.4432% (minimum 75%, Missing); basal ganglia: 71.0306% (minimum 75%, Missing); cerebellum: 62.0438% (minimum 75%, Missing); cerebral cortex: 62.5000% (minimum 75%, Missing); choroid plexus: 57.6923% (minimum 75%, Missing); colon: 69.2935% (minimum 70%, Missing); duodenum: 66.4062% (minimum 75%, Missing); heart muscle: 57.6923% (minimum 70%, Approved); hippocampal formation: 71.8310% (minimum 75%, Missing); hypothalamus: 66.9291% (minimum 75%, Missing); kidney: 55.4348% (minimum 75%, Missing); liver: 64.5570% (minimum 75%, Missing); lymph node: 66.9291% (minimum 70%, Missing); midbrain: 69.4823% (minimum 75%, Missing); pancreas: 66.7539% (minimum 75%, Missing); parathyroid gland: 48.6641% (minimum 70%, Missing); pituitary gland: 66.0622% (minimum 75%, Missing); rectum: 67.6393% (minimum 70%, Missing); retina: 50.0982% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 60.1415% (minimum 75%, Missing); small intestine: 70.8333% (minimum 75%, Missing); smooth muscle: 71.8310% (minimum 75%, Missing); spinal cord: 71.2291% (minimum 75%, Missing); stomach: 66.9291% (minimum 70%, Missing); thymus: 62.0438% (minimum 65%, Missing); tongue: 65.0510% (minimum 70%, Missing)",-0.029562,-0.213359,-0.249018,0,7,partial,25.4,26.9,15.6,"parathyroid gland: 26.9 nTPM (protected, limit 3); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); choroid plexus: 18.7 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 2); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 3); thyroid gland: 13.6 nTPM (manageable, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 3); lymph node: 12.6 nTPM (protected, limit 3); hypothalamus: 12.6 nTPM (vital, limit 1); rectum: 12.2 nTPM (protected, limit 3); salivary gland: 11.9 nTPM (protected, limit 3); colon: 11.3 nTPM (protected, limit 3); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); spleen: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 3); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); bone marrow: 7.5 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108666,C17orf75,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 62.3472% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.4432% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.0306% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.0438% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.5000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 57.6923% (minimum 75%, Baseline (adaptation disabled)); colon: 69.2935% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.4062% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 57.6923% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.8310% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.9291% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.4348% (minimum 75%, Baseline (adaptation disabled)); liver: 64.5570% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.9291% (minimum 70%, Baseline (adaptation disabled)); midbrain: 69.4823% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.7539% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 48.6641% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 66.0622% (minimum 75%, Baseline (adaptation disabled)); rectum: 67.6393% (minimum 70%, Baseline (adaptation disabled)); retina: 50.0982% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.1818% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.1415% (minimum 75%, Baseline (adaptation disabled)); small intestine: 70.8333% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.8310% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.2291% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.9291% (minimum 70%, Baseline (adaptation disabled)); thymus: 62.0438% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.0510% (minimum 70%, Baseline (adaptation disabled))",-0.029562,-0.213359,-0.249018,0,7,partial,25.4,26.9,15.6,"parathyroid gland: 26.9 nTPM (protected, limit 3); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 1); choroid plexus: 18.7 nTPM (vital, limit 1); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 3); thyroid gland: 13.6 nTPM (manageable, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); hypothalamus: 12.6 nTPM (vital, limit 1); lymph node: 12.6 nTPM (protected, limit 3); stomach: 12.6 nTPM (protected, limit 3); rectum: 12.2 nTPM (protected, limit 3); salivary gland: 11.9 nTPM (protected, limit 3); colon: 11.3 nTPM (protected, limit 3); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); spleen: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 3); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); adipose tissue: 7.8 nTPM (manageable, limit 5); bone marrow: 7.5 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108666,C17orf75,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.3724% (minimum 99%, Missing); basal ganglia: 96.2560% (minimum 99%, Missing); choroid plexus: 96.3724% (minimum 99%, Missing); hippocampal formation: 95.9085% (minimum 99%, Missing); hypothalamus: 97.0767% (minimum 99%, Missing); midbrain: 95.9085% (minimum 99%, Missing); pituitary gland: 97.1951% (minimum 99%, Missing); skeletal muscle: 94.8810% (minimum 95%, Enhanced); spinal cord: 96.3724% (minimum 99%, Missing)",0.0450062,0.03,-0.0309146,0,1,partial,4.3,5.9,6.1,"hippocampal formation: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108786,HSD17B1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345006,0.3,0.209085,0,1,partial,4.3,5.9,6.1,"hippocampal formation: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108786,HSD17B1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345006,0.3,0.209085,0,1,partial,4.3,5.9,6.1,"hippocampal formation: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108786,HSD17B1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345006,0.3,0.209085,0,1,partial,4.3,5.9,6.1,"hippocampal formation: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108786,HSD17B1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278904,0.231075,0.19881,0,1,partial,4.3,5.9,6.1,"skin: 6.1 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 3); skeletal muscle: 4.3 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000108786,HSD17B1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.3053% (minimum 90%, Approved); adrenal gland: 76.1905% (minimum 98%, Approved); amygdala: 87.3362% (minimum 99%, Missing); basal ganglia: 87.3362% (minimum 99%, Missing); bone marrow: 71.4286% (minimum 99%, Missing); cerebellum: 86.5801% (minimum 98%, Approved); cerebral cortex: 86.7679% (minimum 98%, Approved); choroid plexus: 77.9727% (minimum 99%, Missing); colon: 60.2410% (minimum 97%, Missing); duodenum: 75.3296% (minimum 99%, Missing); esophagus: 51.3479% (minimum 97%, Missing); heart muscle: 50.5051% (minimum 99%, Missing); hippocampal formation: 88.1057% (minimum 99%, Missing); hypothalamus: 88.1057% (minimum 99%, Missing); kidney: 68.3761% (minimum 98%, Approved); liver: 60.5144% (minimum 99%, Missing); lung: 65.7895% (minimum 99%, Missing); lymph node: 70.6714% (minimum 95%, Approved); midbrain: 86.7679% (minimum 99%, Missing); pancreas: 73.2601% (minimum 98%, Approved); parathyroid gland: 57.4713% (minimum 95%, Approved); pituitary gland: 84.0336% (minimum 99%, Missing); rectum: 62.5000% (minimum 97%, Missing); retina: 71.5564% (minimum 99%, Missing); salivary gland: 67.3401% (minimum 95%, Approved); skeletal muscle: 36.4964% (minimum 99%, Missing); skin: 55.7880% (minimum 95%, Missing); small intestine: 70.2988% (minimum 98%, Approved); smooth muscle: 53.9084% (minimum 99%, Missing); spinal cord: 88.1057% (minimum 99%, Missing); spleen: 71.4286% (minimum 90%, Approved); stomach: 68.8468% (minimum 95%, Approved); thymus: 62.5000% (minimum 95%, Missing); thyroid gland: 66.2252% (minimum 95%, Missing); tongue: 29.6736% (minimum 97%, Missing); urinary bladder: 61.0687% (minimum 97%, Missing)",-0.39212,-0.673264,-0.625036,0,1,partial,69.6,94.8,31.7,"tongue: 94.8 nTPM (protected, limit 2); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 2); smooth muscle: 34.2 nTPM (vital, limit 1); skin: 31.7 nTPM (manageable, limit 5); parathyroid gland: 29.6 nTPM (protected, limit 4); colon: 26.4 nTPM (protected, limit 2); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 2); adipose tissue: 24.2 nTPM (manageable, limit 10); thymus: 24 nTPM (manageable, limit 5); rectum: 24 nTPM (protected, limit 2); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); salivary gland: 19.4 nTPM (protected, limit 4); kidney: 18.5 nTPM (vital, limit 2); stomach: 18.1 nTPM (protected, limit 4); small intestine: 16.9 nTPM (vital, limit 2); lymph node: 16.6 nTPM (protected, limit 4); spleen: 16 nTPM (manageable, limit 10); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); pancreas: 14.6 nTPM (vital, limit 2); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 2); cerebral cortex: 6.1 nTPM (vital, limit 2); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109171,SLAIN2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); colon: 60.2410% (minimum 70%, Missing); esophagus: 51.3479% (minimum 70%, Missing); heart muscle: 50.5051% (minimum 75%, Missing); kidney: 68.3761% (minimum 70%, Approved); liver: 60.5144% (minimum 75%, Missing); lung: 65.7895% (minimum 75%, Missing); parathyroid gland: 57.4713% (minimum 65%, Approved); rectum: 62.5000% (minimum 70%, Missing); retina: 71.5564% (minimum 75%, Missing); skeletal muscle: 36.4964% (minimum 75%, Missing); skin: 55.7880% (minimum 65%, Missing); smooth muscle: 53.9084% (minimum 75%, Missing); thymus: 62.5000% (minimum 65%, Missing); tongue: 29.6736% (minimum 70%, Missing); urinary bladder: 61.0687% (minimum 70%, Missing)",-0.0921199,-0.403264,-0.385036,0,1,partial,69.6,94.8,31.7,"tongue: 94.8 nTPM (protected, limit 2); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 2); smooth muscle: 34.2 nTPM (vital, limit 1); skin: 31.7 nTPM (manageable, limit 5); parathyroid gland: 29.6 nTPM (protected, limit 4); colon: 26.4 nTPM (protected, limit 2); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 2); adipose tissue: 24.2 nTPM (manageable, limit 10); thymus: 24 nTPM (manageable, limit 5); rectum: 24 nTPM (protected, limit 2); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); salivary gland: 19.4 nTPM (protected, limit 4); kidney: 18.5 nTPM (vital, limit 2); stomach: 18.1 nTPM (protected, limit 4); small intestine: 16.9 nTPM (vital, limit 2); lymph node: 16.6 nTPM (protected, limit 4); spleen: 16 nTPM (manageable, limit 10); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); pancreas: 14.6 nTPM (vital, limit 2); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 2); cerebral cortex: 6.1 nTPM (vital, limit 2); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109171,SLAIN2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); colon: 60.2410% (minimum 70%, Missing); esophagus: 51.3479% (minimum 70%, Missing); heart muscle: 50.5051% (minimum 75%, Missing); kidney: 68.3761% (minimum 70%, Approved); liver: 60.5144% (minimum 75%, Missing); lung: 65.7895% (minimum 75%, Missing); parathyroid gland: 57.4713% (minimum 65%, Approved); rectum: 62.5000% (minimum 70%, Missing); retina: 71.5564% (minimum 75%, Missing); skeletal muscle: 36.4964% (minimum 75%, Missing); skin: 55.7880% (minimum 65%, Missing); smooth muscle: 53.9084% (minimum 75%, Missing); thymus: 62.5000% (minimum 65%, Missing); tongue: 29.6736% (minimum 70%, Missing); urinary bladder: 61.0687% (minimum 70%, Missing)",-0.0921199,-0.403264,-0.385036,0,1,partial,69.6,94.8,31.7,"tongue: 94.8 nTPM (protected, limit 3); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 3); smooth muscle: 34.2 nTPM (vital, limit 1); skin: 31.7 nTPM (manageable, limit 5); parathyroid gland: 29.6 nTPM (protected, limit 4); colon: 26.4 nTPM (protected, limit 3); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 3); adipose tissue: 24.2 nTPM (manageable, limit 10); thymus: 24 nTPM (manageable, limit 5); rectum: 24 nTPM (protected, limit 3); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); salivary gland: 19.4 nTPM (protected, limit 4); kidney: 18.5 nTPM (vital, limit 2); stomach: 18.1 nTPM (protected, limit 4); small intestine: 16.9 nTPM (vital, limit 2); lymph node: 16.6 nTPM (protected, limit 4); spleen: 16 nTPM (manageable, limit 10); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); pancreas: 14.6 nTPM (vital, limit 2); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 2); cerebral cortex: 6.1 nTPM (vital, limit 2); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109171,SLAIN2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); colon: 60.2410% (minimum 70%, Missing); esophagus: 51.3479% (minimum 70%, Missing); heart muscle: 50.5051% (minimum 75%, Missing); kidney: 68.3761% (minimum 70%, Approved); liver: 60.5144% (minimum 75%, Missing); lung: 65.7895% (minimum 75%, Missing); parathyroid gland: 57.4713% (minimum 65%, Approved); rectum: 62.5000% (minimum 70%, Missing); retina: 71.5564% (minimum 75%, Missing); skeletal muscle: 36.4964% (minimum 75%, Missing); skin: 55.7880% (minimum 65%, Missing); smooth muscle: 53.9084% (minimum 75%, Missing); thymus: 62.5000% (minimum 65%, Missing); tongue: 29.6736% (minimum 70%, Missing); urinary bladder: 61.0687% (minimum 70%, Missing)",-0.0921199,-0.403264,-0.385036,0,1,partial,69.6,94.8,31.7,"tongue: 94.8 nTPM (protected, limit 3); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 3); smooth muscle: 34.2 nTPM (vital, limit 1); skin: 31.7 nTPM (manageable, limit 5); parathyroid gland: 29.6 nTPM (protected, limit 4); colon: 26.4 nTPM (protected, limit 3); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 3); adipose tissue: 24.2 nTPM (manageable, limit 10); thymus: 24 nTPM (manageable, limit 5); rectum: 24 nTPM (protected, limit 3); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); salivary gland: 19.4 nTPM (protected, limit 4); kidney: 18.5 nTPM (vital, limit 2); stomach: 18.1 nTPM (protected, limit 4); small intestine: 16.9 nTPM (vital, limit 2); lymph node: 16.6 nTPM (protected, limit 4); spleen: 16 nTPM (manageable, limit 10); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); pancreas: 14.6 nTPM (vital, limit 2); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 2); cerebral cortex: 6.1 nTPM (vital, limit 2); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109171,SLAIN2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.3053% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 71.4286% (minimum 75%, Baseline (adaptation disabled)); colon: 60.2410% (minimum 70%, Baseline (adaptation disabled)); esophagus: 51.3479% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 50.5051% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.3761% (minimum 75%, Baseline (adaptation disabled)); liver: 60.5144% (minimum 75%, Baseline (adaptation disabled)); lung: 65.7895% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.2601% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.4713% (minimum 70%, Baseline (adaptation disabled)); rectum: 62.5000% (minimum 70%, Baseline (adaptation disabled)); retina: 71.5564% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 67.3401% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 36.4964% (minimum 75%, Baseline (adaptation disabled)); skin: 55.7880% (minimum 65%, Baseline (adaptation disabled)); small intestine: 70.2988% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.9084% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.8468% (minimum 70%, Baseline (adaptation disabled)); thymus: 62.5000% (minimum 65%, Baseline (adaptation disabled)); tongue: 29.6736% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.0687% (minimum 70%, Baseline (adaptation disabled))",-0.0921199,-0.403264,-0.385036,0,1,partial,69.6,94.8,31.7,"tongue: 94.8 nTPM (protected, limit 3); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 3); smooth muscle: 34.2 nTPM (vital, limit 1); skin: 31.7 nTPM (manageable, limit 5); parathyroid gland: 29.6 nTPM (protected, limit 3); colon: 26.4 nTPM (protected, limit 3); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 3); adipose tissue: 24.2 nTPM (manageable, limit 5); thymus: 24 nTPM (manageable, limit 5); rectum: 24 nTPM (protected, limit 3); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); salivary gland: 19.4 nTPM (protected, limit 3); kidney: 18.5 nTPM (vital, limit 1); stomach: 18.1 nTPM (protected, limit 3); small intestine: 16.9 nTPM (vital, limit 1); lymph node: 16.6 nTPM (protected, limit 3); spleen: 16 nTPM (manageable, limit 5); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); pancreas: 14.6 nTPM (vital, limit 1); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109171,SLAIN2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0000% (minimum 95%, Missing); adrenal gland: 48.9614% (minimum 99%, Missing); amygdala: 56.7010% (minimum 99%, Missing); basal ganglia: 55.5556% (minimum 99%, Missing); bone marrow: 85.4922% (minimum 99%, Missing); cerebellum: 56.1224% (minimum 99%, Missing); cerebral cortex: 52.8846% (minimum 99%, Missing); choroid plexus: 74.3243% (minimum 99%, Missing); colon: 53.2258% (minimum 97%, Missing); duodenum: 74.3243% (minimum 99%, Missing); esophagus: 62.2642% (minimum 97%, Missing); heart muscle: 58.5106% (minimum 99%, Uncertain); hippocampal formation: 55.5556% (minimum 99%, Missing); hypothalamus: 47.0085% (minimum 99%, Missing); kidney: 53.5714% (minimum 99%, Missing); liver: 37.0787% (minimum 99%, Missing); lung: 65.2174% (minimum 99%, Missing); lymph node: 69.3277% (minimum 97%, Missing); midbrain: 52.3810% (minimum 99%, Missing); pancreas: 65.2174% (minimum 99%, Missing); parathyroid gland: 64.2023% (minimum 97%, Missing); pituitary gland: 51.8868% (minimum 99%, Missing); rectum: 66.8016% (minimum 97%, Missing); retina: 52.0505% (minimum 99%, Missing); salivary gland: 55.7432% (minimum 97%, Missing); skeletal muscle: 59.1398% (minimum 99%, Uncertain); skin: 68.7500% (minimum 95%, Missing); small intestine: 63.7066% (minimum 99%, Missing); smooth muscle: 49.8489% (minimum 99%, Missing); spinal cord: 53.7459% (minimum 99%, Missing); spleen: 64.2023% (minimum 95%, Missing); stomach: 56.1224% (minimum 97%, Missing); thymus: 72.3684% (minimum 95%, Missing); thyroid gland: 56.3140% (minimum 95%, Missing); tongue: 60.2190% (minimum 97%, Missing); urinary bladder: 50.1520% (minimum 97%, Missing)",-0.4,-0.46848,-0.619213,0,3,partial,28,16.4,13.5,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 2); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 2); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 2); cerebellum: 12.9 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); thyroid gland: 12.8 nTPM (manageable, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 2); esophagus: 10 nTPM (protected, limit 2); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); spleen: 9.2 nTPM (manageable, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 2); skin: 7.5 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109184,DCUN1D4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); adrenal gland: 48.9614% (minimum 75%, Missing); amygdala: 56.7010% (minimum 75%, Missing); basal ganglia: 55.5556% (minimum 75%, Missing); cerebellum: 56.1224% (minimum 75%, Missing); cerebral cortex: 52.8846% (minimum 75%, Missing); choroid plexus: 74.3243% (minimum 75%, Missing); colon: 53.2258% (minimum 70%, Missing); duodenum: 74.3243% (minimum 75%, Missing); esophagus: 62.2642% (minimum 70%, Missing); heart muscle: 58.5106% (minimum 75%, Uncertain); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 47.0085% (minimum 75%, Missing); kidney: 53.5714% (minimum 75%, Missing); liver: 37.0787% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); lymph node: 69.3277% (minimum 70%, Missing); midbrain: 52.3810% (minimum 75%, Missing); pancreas: 65.2174% (minimum 75%, Missing); parathyroid gland: 64.2023% (minimum 70%, Missing); pituitary gland: 51.8868% (minimum 75%, Missing); rectum: 66.8016% (minimum 70%, Missing); retina: 52.0505% (minimum 75%, Missing); salivary gland: 55.7432% (minimum 70%, Missing); skeletal muscle: 59.1398% (minimum 75%, Uncertain); small intestine: 63.7066% (minimum 75%, Missing); smooth muscle: 49.8489% (minimum 75%, Missing); spinal cord: 53.7459% (minimum 75%, Missing); spleen: 64.2023% (minimum 65%, Missing); stomach: 56.1224% (minimum 70%, Missing); thyroid gland: 56.3140% (minimum 65%, Missing); tongue: 60.2190% (minimum 70%, Missing); urinary bladder: 50.1520% (minimum 70%, Missing)",-0.1,-0.19848,-0.379213,0,3,partial,28,16.4,13.5,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 2); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 2); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 2); cerebellum: 12.9 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); thyroid gland: 12.8 nTPM (manageable, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 2); esophagus: 10 nTPM (protected, limit 2); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); spleen: 9.2 nTPM (manageable, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 2); skin: 7.5 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109184,DCUN1D4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); adrenal gland: 48.9614% (minimum 75%, Missing); amygdala: 56.7010% (minimum 75%, Missing); basal ganglia: 55.5556% (minimum 75%, Missing); cerebellum: 56.1224% (minimum 75%, Missing); cerebral cortex: 52.8846% (minimum 75%, Missing); choroid plexus: 74.3243% (minimum 75%, Missing); colon: 53.2258% (minimum 70%, Missing); duodenum: 74.3243% (minimum 75%, Missing); esophagus: 62.2642% (minimum 70%, Missing); heart muscle: 58.5106% (minimum 75%, Uncertain); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 47.0085% (minimum 75%, Missing); kidney: 53.5714% (minimum 75%, Missing); liver: 37.0787% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); lymph node: 69.3277% (minimum 70%, Missing); midbrain: 52.3810% (minimum 75%, Missing); pancreas: 65.2174% (minimum 75%, Missing); parathyroid gland: 64.2023% (minimum 70%, Missing); pituitary gland: 51.8868% (minimum 75%, Missing); rectum: 66.8016% (minimum 70%, Missing); retina: 52.0505% (minimum 75%, Missing); salivary gland: 55.7432% (minimum 70%, Missing); skeletal muscle: 59.1398% (minimum 75%, Uncertain); small intestine: 63.7066% (minimum 75%, Missing); smooth muscle: 49.8489% (minimum 75%, Missing); spinal cord: 53.7459% (minimum 75%, Missing); spleen: 64.2023% (minimum 65%, Missing); stomach: 56.1224% (minimum 70%, Missing); thyroid gland: 56.3140% (minimum 65%, Missing); tongue: 60.2190% (minimum 70%, Missing); urinary bladder: 50.1520% (minimum 70%, Missing)",-0.1,-0.19848,-0.379213,0,3,partial,28,16.4,13.5,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 3); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 3); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 3); cerebellum: 12.9 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); thyroid gland: 12.8 nTPM (manageable, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 3); esophagus: 10 nTPM (protected, limit 3); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); spleen: 9.2 nTPM (manageable, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 3); skin: 7.5 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109184,DCUN1D4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); adrenal gland: 48.9614% (minimum 75%, Missing); amygdala: 56.7010% (minimum 75%, Missing); basal ganglia: 55.5556% (minimum 75%, Missing); cerebellum: 56.1224% (minimum 75%, Missing); cerebral cortex: 52.8846% (minimum 75%, Missing); choroid plexus: 74.3243% (minimum 75%, Missing); colon: 53.2258% (minimum 70%, Missing); duodenum: 74.3243% (minimum 75%, Missing); esophagus: 62.2642% (minimum 70%, Missing); heart muscle: 58.5106% (minimum 75%, Uncertain); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 47.0085% (minimum 75%, Missing); kidney: 53.5714% (minimum 75%, Missing); liver: 37.0787% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); lymph node: 69.3277% (minimum 70%, Missing); midbrain: 52.3810% (minimum 75%, Missing); pancreas: 65.2174% (minimum 75%, Missing); parathyroid gland: 64.2023% (minimum 70%, Missing); pituitary gland: 51.8868% (minimum 75%, Missing); rectum: 66.8016% (minimum 70%, Missing); retina: 52.0505% (minimum 75%, Missing); salivary gland: 55.7432% (minimum 70%, Missing); skeletal muscle: 59.1398% (minimum 75%, Uncertain); small intestine: 63.7066% (minimum 75%, Missing); smooth muscle: 49.8489% (minimum 75%, Missing); spinal cord: 53.7459% (minimum 75%, Missing); spleen: 64.2023% (minimum 65%, Missing); stomach: 56.1224% (minimum 70%, Missing); thyroid gland: 56.3140% (minimum 65%, Missing); tongue: 60.2190% (minimum 70%, Missing); urinary bladder: 50.1520% (minimum 70%, Missing)",-0.1,-0.19848,-0.379213,0,3,partial,28,16.4,13.5,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 3); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 3); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 3); cerebellum: 12.9 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); thyroid gland: 12.8 nTPM (manageable, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 3); esophagus: 10 nTPM (protected, limit 3); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); spleen: 9.2 nTPM (manageable, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 3); skin: 7.5 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109184,DCUN1D4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 48.9614% (minimum 75%, Baseline (adaptation disabled)); amygdala: 56.7010% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.5556% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.1224% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 52.8846% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.3243% (minimum 75%, Baseline (adaptation disabled)); colon: 53.2258% (minimum 70%, Baseline (adaptation disabled)); duodenum: 74.3243% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.2642% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.5106% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.5556% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 47.0085% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.5714% (minimum 75%, Baseline (adaptation disabled)); liver: 37.0787% (minimum 75%, Baseline (adaptation disabled)); lung: 65.2174% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.3277% (minimum 70%, Baseline (adaptation disabled)); midbrain: 52.3810% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.2174% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.2023% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 51.8868% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.8016% (minimum 70%, Baseline (adaptation disabled)); retina: 52.0505% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.7432% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 59.1398% (minimum 75%, Baseline (adaptation disabled)); small intestine: 63.7066% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 49.8489% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.7459% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.2023% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.1224% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 56.3140% (minimum 65%, Baseline (adaptation disabled)); tongue: 60.2190% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 50.1520% (minimum 70%, Baseline (adaptation disabled))",-0.1,-0.19848,-0.379213,0,3,partial,28,16.4,13.5,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 3); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 3); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 3); cerebellum: 12.9 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); thyroid gland: 12.8 nTPM (manageable, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 3); esophagus: 10 nTPM (protected, limit 3); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); spleen: 9.2 nTPM (manageable, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 3); skin: 7.5 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109184,DCUN1D4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 93.1148% (minimum 99%, Missing); amygdala: 92.5081% (minimum 99%, Missing); basal ganglia: 93.4211% (minimum 99%, Missing); bone marrow: 87.9257% (minimum 99%, Missing); cerebellum: 91.9094% (minimum 99%, Missing); cerebral cortex: 83.2845% (minimum 99%, Missing); choroid plexus: 98.9547% (minimum 99%, Missing); colon: 76.3441% (minimum 97%, Missing); duodenum: 68.7651% (minimum 99%, Missing); heart muscle: 97.2603% (minimum 99%, Missing); hippocampal formation: 92.8105% (minimum 99%, Missing); hypothalamus: 87.3846% (minimum 99%, Missing); kidney: 97.5945% (minimum 99%, Missing); liver: 97.9310% (minimum 99%, Uncertain); lung: 97.2603% (minimum 99%, Uncertain); lymph node: 93.1148% (minimum 97%, Uncertain); midbrain: 89.0282% (minimum 99%, Missing); pancreas: 95.6229% (minimum 99%, Missing); parathyroid gland: 83.0409% (minimum 97%, Missing); pituitary gland: 96.9283% (minimum 99%, Missing); rectum: 79.1086% (minimum 97%, Missing); retina: 87.3846% (minimum 99%, Missing); salivary gland: 96.5986% (minimum 97%, Missing); small intestine: 60.1695% (minimum 99%, Missing); smooth muscle: 87.3846% (minimum 99%, Missing); spinal cord: 92.2078% (minimum 99%, Missing); spleen: 92.5081% (minimum 95%, Uncertain); stomach: 91.6129% (minimum 97%, Missing); urinary bladder: 95.9459% (minimum 97%, Missing)",-0.0249186,-0.206559,-0.388305,0,1,partial,18.8,8.8,2.3,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 2); rectum: 7.5 nTPM (protected, limit 2); parathyroid gland: 5.8 nTPM (protected, limit 2); cerebral cortex: 5.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109265,CRACD,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 68.7651% (minimum 75%, Missing); small intestine: 60.1695% (minimum 75%, Missing)",0.275081,0.0634409,-0.148305,0,1,partial,18.8,8.8,2.3,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 2); rectum: 7.5 nTPM (protected, limit 2); parathyroid gland: 5.8 nTPM (protected, limit 2); cerebral cortex: 5.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109265,CRACD,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 68.7651% (minimum 75%, Missing); small intestine: 60.1695% (minimum 75%, Missing)",0.275081,0.0634409,-0.148305,0,1,partial,18.8,8.8,2.3,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 3); rectum: 7.5 nTPM (protected, limit 3); parathyroid gland: 5.8 nTPM (protected, limit 3); cerebral cortex: 5.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109265,CRACD,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 68.7651% (minimum 75%, Missing); small intestine: 60.1695% (minimum 75%, Missing)",0.275081,0.0634409,-0.148305,0,1,partial,18.8,8.8,2.3,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 3); rectum: 7.5 nTPM (protected, limit 3); parathyroid gland: 5.8 nTPM (protected, limit 3); cerebral cortex: 5.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109265,CRACD,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 68.7651% (minimum 75%, Baseline (adaptation disabled)); small intestine: 60.1695% (minimum 75%, Baseline (adaptation disabled))",0.275081,0.0634409,-0.148305,0,1,partial,18.8,8.8,2.3,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 3); rectum: 7.5 nTPM (protected, limit 3); parathyroid gland: 5.8 nTPM (protected, limit 3); cerebral cortex: 5.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109265,CRACD,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.0870% (minimum 95%, Missing); adrenal gland: 58.0247% (minimum 99%, Missing); amygdala: 68.1159% (minimum 99%, Missing); basal ganglia: 69.1176% (minimum 99%, Missing); bone marrow: 88.6792% (minimum 99%, Missing); cerebellum: 58.0247% (minimum 99%, Missing); cerebral cortex: 73.4375% (minimum 99%, Missing); choroid plexus: 75.8065% (minimum 99%, Missing); colon: 47.9592% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 60.2564% (minimum 97%, Missing); heart muscle: 63.5135% (minimum 99%, Missing); hippocampal formation: 65.2778% (minimum 99%, Missing); hypothalamus: 68.1159% (minimum 99%, Missing); kidney: 37.3016% (minimum 99%, Missing); liver: 15.6667% (minimum 99%, Missing); lung: 55.2941% (minimum 99%, Missing); lymph node: 70.1493% (minimum 97%, Missing); midbrain: 62.6667% (minimum 99%, Missing); pancreas: 39.4958% (minimum 99%, Missing); parathyroid gland: 59.4937% (minimum 97%, Missing); pituitary gland: 61.0390% (minimum 99%, Missing); rectum: 63.5135% (minimum 97%, Missing); retina: 75.8065% (minimum 99%, Missing); salivary gland: 55.9524% (minimum 97%, Missing); skeletal muscle: 58.7500% (minimum 99%, Missing); skin: 48.4536% (minimum 95%, Missing); small intestine: 38.8430% (minimum 99%, Missing); smooth muscle: 78.3333% (minimum 99%, Missing); spinal cord: 54.0230% (minimum 99%, Missing); spleen: 46.0784% (minimum 95%, Missing); stomach: 48.9583% (minimum 97%, Missing); thymus: 48.4536% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 65.2778% (minimum 97%, Missing); urinary bladder: 55.9524% (minimum 97%, Missing)",-0.489216,-0.490408,-0.833333,0,80,unavailable,25.3,5.1,5.5,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); colon: 5.1 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); salivary gland: 3.7 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109618,SEPSECS,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.0870% (minimum 65%, Missing); adrenal gland: 58.0247% (minimum 75%, Missing); amygdala: 68.1159% (minimum 75%, Missing); basal ganglia: 69.1176% (minimum 75%, Missing); cerebellum: 58.0247% (minimum 75%, Missing); cerebral cortex: 73.4375% (minimum 75%, Missing); colon: 47.9592% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 60.2564% (minimum 70%, Missing); heart muscle: 63.5135% (minimum 75%, Missing); hippocampal formation: 65.2778% (minimum 75%, Missing); hypothalamus: 68.1159% (minimum 75%, Missing); kidney: 37.3016% (minimum 75%, Missing); liver: 15.6667% (minimum 75%, Missing); lung: 55.2941% (minimum 75%, Missing); midbrain: 62.6667% (minimum 75%, Missing); pancreas: 39.4958% (minimum 75%, Missing); parathyroid gland: 59.4937% (minimum 70%, Missing); pituitary gland: 61.0390% (minimum 75%, Missing); rectum: 63.5135% (minimum 70%, Missing); salivary gland: 55.9524% (minimum 70%, Missing); skeletal muscle: 58.7500% (minimum 75%, Missing); skin: 48.4536% (minimum 65%, Missing); small intestine: 38.8430% (minimum 75%, Missing); spinal cord: 54.0230% (minimum 75%, Missing); spleen: 46.0784% (minimum 65%, Missing); stomach: 48.9583% (minimum 70%, Missing); thymus: 48.4536% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 65.2778% (minimum 70%, Missing); urinary bladder: 55.9524% (minimum 70%, Missing)",-0.189216,-0.220408,-0.593333,0,80,unavailable,25.3,5.1,5.5,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); colon: 5.1 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); salivary gland: 3.7 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109618,SEPSECS,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.0870% (minimum 65%, Missing); adrenal gland: 58.0247% (minimum 75%, Missing); amygdala: 68.1159% (minimum 75%, Missing); basal ganglia: 69.1176% (minimum 75%, Missing); cerebellum: 58.0247% (minimum 75%, Missing); cerebral cortex: 73.4375% (minimum 75%, Missing); colon: 47.9592% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 60.2564% (minimum 70%, Missing); heart muscle: 63.5135% (minimum 75%, Missing); hippocampal formation: 65.2778% (minimum 75%, Missing); hypothalamus: 68.1159% (minimum 75%, Missing); kidney: 37.3016% (minimum 75%, Missing); liver: 15.6667% (minimum 75%, Missing); lung: 55.2941% (minimum 75%, Missing); midbrain: 62.6667% (minimum 75%, Missing); pancreas: 39.4958% (minimum 75%, Missing); parathyroid gland: 59.4937% (minimum 70%, Missing); pituitary gland: 61.0390% (minimum 75%, Missing); rectum: 63.5135% (minimum 70%, Missing); salivary gland: 55.9524% (minimum 70%, Missing); skeletal muscle: 58.7500% (minimum 75%, Missing); skin: 48.4536% (minimum 65%, Missing); small intestine: 38.8430% (minimum 75%, Missing); spinal cord: 54.0230% (minimum 75%, Missing); spleen: 46.0784% (minimum 65%, Missing); stomach: 48.9583% (minimum 70%, Missing); thymus: 48.4536% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 65.2778% (minimum 70%, Missing); urinary bladder: 55.9524% (minimum 70%, Missing)",-0.189216,-0.220408,-0.593333,0,80,unavailable,25.3,5.1,5.5,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); colon: 5.1 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109618,SEPSECS,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.0870% (minimum 65%, Missing); adrenal gland: 58.0247% (minimum 75%, Missing); amygdala: 68.1159% (minimum 75%, Missing); basal ganglia: 69.1176% (minimum 75%, Missing); cerebellum: 58.0247% (minimum 75%, Missing); cerebral cortex: 73.4375% (minimum 75%, Missing); colon: 47.9592% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 60.2564% (minimum 70%, Missing); heart muscle: 63.5135% (minimum 75%, Missing); hippocampal formation: 65.2778% (minimum 75%, Missing); hypothalamus: 68.1159% (minimum 75%, Missing); kidney: 37.3016% (minimum 75%, Missing); liver: 15.6667% (minimum 75%, Missing); lung: 55.2941% (minimum 75%, Missing); midbrain: 62.6667% (minimum 75%, Missing); pancreas: 39.4958% (minimum 75%, Missing); parathyroid gland: 59.4937% (minimum 70%, Missing); pituitary gland: 61.0390% (minimum 75%, Missing); rectum: 63.5135% (minimum 70%, Missing); salivary gland: 55.9524% (minimum 70%, Missing); skeletal muscle: 58.7500% (minimum 75%, Missing); skin: 48.4536% (minimum 65%, Missing); small intestine: 38.8430% (minimum 75%, Missing); spinal cord: 54.0230% (minimum 75%, Missing); spleen: 46.0784% (minimum 65%, Missing); stomach: 48.9583% (minimum 70%, Missing); thymus: 48.4536% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 65.2778% (minimum 70%, Missing); urinary bladder: 55.9524% (minimum 70%, Missing)",-0.189216,-0.220408,-0.593333,0,80,unavailable,25.3,5.1,5.5,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); colon: 5.1 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109618,SEPSECS,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.0870% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 58.0247% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.1159% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 69.1176% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 58.0247% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.4375% (minimum 75%, Baseline (adaptation disabled)); colon: 47.9592% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.2564% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.5135% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.2778% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.1159% (minimum 75%, Baseline (adaptation disabled)); kidney: 37.3016% (minimum 75%, Baseline (adaptation disabled)); liver: 15.6667% (minimum 75%, Baseline (adaptation disabled)); lung: 55.2941% (minimum 75%, Baseline (adaptation disabled)); midbrain: 62.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 39.4958% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.4937% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 61.0390% (minimum 75%, Baseline (adaptation disabled)); rectum: 63.5135% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 55.9524% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 58.7500% (minimum 75%, Baseline (adaptation disabled)); skin: 48.4536% (minimum 65%, Baseline (adaptation disabled)); small intestine: 38.8430% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 54.0230% (minimum 75%, Baseline (adaptation disabled)); spleen: 46.0784% (minimum 65%, Baseline (adaptation disabled)); stomach: 48.9583% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.4536% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.2778% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 55.9524% (minimum 70%, Baseline (adaptation disabled))",-0.189216,-0.220408,-0.593333,0,80,unavailable,25.3,5.1,5.5,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); colon: 5.1 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109618,SEPSECS,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Missing); bone marrow: 18.7500% (minimum 99%, Missing); cerebral cortex: 88.2353% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 57.6923% (minimum 99%, Missing); esophagus: 50.0000% (minimum 97%, Missing); liver: 88.2353% (minimum 99%, Missing); lung: 93.7500% (minimum 99%, Missing); lymph node: 30.0000% (minimum 97%, Missing); rectum: 51.7241% (minimum 97%, Missing); salivary gland: 88.2353% (minimum 97%, Missing); skin: 39.4737% (minimum 95%, Missing); small intestine: 55.5556% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spleen: 78.9474% (minimum 95%, Missing); stomach: 71.4286% (minimum 97%, Missing); thymus: 6.1224% (minimum 95%, Missing); urinary bladder: 78.9474% (minimum 97%, Missing)",-0.888776,-0.67,-0.8025,0,80,unavailable,6.5,3.5,23,"thymus: 23 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109674,NEIL3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 18.7500% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 57.6923% (minimum 75%, Missing); esophagus: 50.0000% (minimum 70%, Missing); lymph node: 30.0000% (minimum 70%, Missing); rectum: 51.7241% (minimum 70%, Missing); skin: 39.4737% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); thymus: 6.1224% (minimum 65%, Missing)",-0.588776,-0.4,-0.5625,0,80,unavailable,6.5,3.5,23,"thymus: 23 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109674,NEIL3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 18.7500% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 57.6923% (minimum 75%, Missing); esophagus: 50.0000% (minimum 70%, Missing); lymph node: 30.0000% (minimum 70%, Missing); rectum: 51.7241% (minimum 70%, Missing); skin: 39.4737% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); thymus: 6.1224% (minimum 65%, Missing)",-0.588776,-0.4,-0.5625,0,80,unavailable,6.5,3.5,23,"thymus: 23 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109674,NEIL3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 18.7500% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 57.6923% (minimum 75%, Missing); esophagus: 50.0000% (minimum 70%, Missing); lymph node: 30.0000% (minimum 70%, Missing); rectum: 51.7241% (minimum 70%, Missing); skin: 39.4737% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); thymus: 6.1224% (minimum 65%, Missing)",-0.588776,-0.4,-0.5625,0,80,unavailable,6.5,3.5,23,"thymus: 23 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109674,NEIL3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 18.7500% (minimum 75%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.6923% (minimum 75%, Baseline (adaptation disabled)); esophagus: 50.0000% (minimum 70%, Baseline (adaptation disabled)); lymph node: 30.0000% (minimum 70%, Baseline (adaptation disabled)); rectum: 51.7241% (minimum 70%, Baseline (adaptation disabled)); skin: 39.4737% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.5556% (minimum 75%, Baseline (adaptation disabled)); thymus: 6.1224% (minimum 65%, Baseline (adaptation disabled))",-0.588776,-0.4,-0.5625,0,80,unavailable,6.5,3.5,23,"thymus: 23 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109674,NEIL3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.5714% (minimum 95%, Uncertain); adrenal gland: 84.6154% (minimum 99%, Uncertain); bone marrow: 73.3333% (minimum 99%, Uncertain); cerebral cortex: 91.6667% (minimum 99%, Uncertain); choroid plexus: 91.6667% (minimum 99%, Missing); colon: 78.5714% (minimum 97%, Uncertain); duodenum: 68.7500% (minimum 99%, Uncertain); esophagus: 78.5714% (minimum 97%, Uncertain); heart muscle: 84.6154% (minimum 99%, Uncertain); kidney: 15.2778% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Uncertain); lung: 68.7500% (minimum 99%, Uncertain); lymph node: 29.7297% (minimum 97%, Missing); pancreas: 91.6667% (minimum 99%, Missing); parathyroid gland: 91.6667% (minimum 97%, Uncertain); pituitary gland: 47.8261% (minimum 99%, Missing); rectum: 73.3333% (minimum 97%, Uncertain); retina: 78.5714% (minimum 99%, Missing); salivary gland: 73.3333% (minimum 97%, Uncertain); skeletal muscle: 91.6667% (minimum 99%, Uncertain); skin: 57.8947% (minimum 95%, Uncertain); small intestine: 57.8947% (minimum 99%, Uncertain); smooth muscle: 91.6667% (minimum 99%, Uncertain); spleen: 44.0000% (minimum 95%, Uncertain); stomach: 50.0000% (minimum 97%, Uncertain); thymus: 47.8261% (minimum 95%, Missing); thyroid gland: 84.6154% (minimum 95%, Uncertain); urinary bladder: 84.6154% (minimum 97%, Uncertain)",-0.51,-0.672703,-0.837222,0,3,partial,6.1,2.6,1.4,"kidney: 6.1 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109684,CLNK,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 73.3333% (minimum 75%, Uncertain); duodenum: 68.7500% (minimum 75%, Uncertain); kidney: 15.2778% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Uncertain); lung: 68.7500% (minimum 75%, Uncertain); lymph node: 29.7297% (minimum 70%, Missing); pituitary gland: 47.8261% (minimum 75%, Missing); skin: 57.8947% (minimum 65%, Uncertain); small intestine: 57.8947% (minimum 75%, Uncertain); spleen: 44.0000% (minimum 65%, Uncertain); stomach: 50.0000% (minimum 70%, Uncertain); thymus: 47.8261% (minimum 65%, Missing)",-0.21,-0.402703,-0.597222,0,3,partial,6.1,2.6,1.4,"kidney: 6.1 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109684,CLNK,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 73.3333% (minimum 75%, Uncertain); duodenum: 68.7500% (minimum 75%, Uncertain); kidney: 15.2778% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Uncertain); lung: 68.7500% (minimum 75%, Uncertain); lymph node: 29.7297% (minimum 70%, Missing); pituitary gland: 47.8261% (minimum 75%, Missing); skin: 57.8947% (minimum 65%, Uncertain); small intestine: 57.8947% (minimum 75%, Uncertain); spleen: 44.0000% (minimum 65%, Uncertain); stomach: 50.0000% (minimum 70%, Uncertain); thymus: 47.8261% (minimum 65%, Missing)",-0.21,-0.402703,-0.597222,0,3,partial,6.1,2.6,1.4,"kidney: 6.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109684,CLNK,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 73.3333% (minimum 75%, Uncertain); duodenum: 68.7500% (minimum 75%, Uncertain); kidney: 15.2778% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Uncertain); lung: 68.7500% (minimum 75%, Uncertain); lymph node: 29.7297% (minimum 70%, Missing); pituitary gland: 47.8261% (minimum 75%, Missing); skin: 57.8947% (minimum 65%, Uncertain); small intestine: 57.8947% (minimum 75%, Uncertain); spleen: 44.0000% (minimum 65%, Uncertain); stomach: 50.0000% (minimum 70%, Uncertain); thymus: 47.8261% (minimum 65%, Missing)",-0.21,-0.402703,-0.597222,0,3,partial,6.1,2.6,1.4,"kidney: 6.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109684,CLNK,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 73.3333% (minimum 75%, Baseline (adaptation disabled)); duodenum: 68.7500% (minimum 75%, Baseline (adaptation disabled)); kidney: 15.2778% (minimum 75%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 75%, Baseline (adaptation disabled)); lung: 68.7500% (minimum 75%, Baseline (adaptation disabled)); lymph node: 29.7297% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 47.8261% (minimum 75%, Baseline (adaptation disabled)); skin: 57.8947% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.8947% (minimum 75%, Baseline (adaptation disabled)); spleen: 44.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.8261% (minimum 65%, Baseline (adaptation disabled))",-0.21,-0.402703,-0.597222,0,3,partial,6.1,2.6,1.4,"kidney: 6.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109684,CLNK,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.6667% (minimum 90%, Approved); adrenal gland: 83.8710% (minimum 98%, Approved); amygdala: 58.1006% (minimum 99%, Missing); basal ganglia: 56.5217% (minimum 99%, Missing); bone marrow: 96.2963% (minimum 98%, Approved); cerebellum: 45.2174% (minimum 99%, Missing); cerebral cortex: 58.7571% (minimum 99%, Missing); choroid plexus: 74.2857% (minimum 99%, Missing); colon: 74.8201% (minimum 97%, Missing); duodenum: 97.1963% (minimum 98%, Approved); esophagus: 91.2281% (minimum 95%, Approved); heart muscle: 74.8201% (minimum 99%, Missing); hippocampal formation: 55.9140% (minimum 99%, Missing); hypothalamus: 53.8860% (minimum 99%, Missing); kidney: 68.8742% (minimum 98%, Approved); liver: 87.3950% (minimum 98%, Approved); lung: 70.7483% (minimum 98%, Approved); lymph node: 94.5455% (minimum 95%, Approved); midbrain: 67.0968% (minimum 99%, Missing); pancreas: 77.0370% (minimum 98%, Approved); pituitary gland: 38.0952% (minimum 99%, Missing); retina: 27.0833% (minimum 99%, Missing); salivary gland: 88.1356% (minimum 95%, Approved); skeletal muscle: 78.1955% (minimum 99%, Missing); skin: 87.3950% (minimum 95%, Missing); small intestine: 85.2459% (minimum 98%, Approved); smooth muscle: 97.1963% (minimum 99%, Missing); spinal cord: 64.5963% (minimum 99%, Missing); spleen: 80.0000% (minimum 90%, Approved); stomach: 86.6667% (minimum 95%, Approved); thyroid gland: 75.3623% (minimum 90%, Approved); tongue: 93.6937% (minimum 97%, Missing); urinary bladder: 83.8710% (minimum 95%, Approved)",-0.146377,-0.221799,-0.719167,0,2,partial,28,3.5,3.4,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 2); lung: 4.3 nTPM (vital, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109771,LRP2BP,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.1006% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); cerebellum: 45.2174% (minimum 75%, Missing); cerebral cortex: 58.7571% (minimum 75%, Missing); choroid plexus: 74.2857% (minimum 75%, Missing); heart muscle: 74.8201% (minimum 75%, Missing); hippocampal formation: 55.9140% (minimum 75%, Missing); hypothalamus: 53.8860% (minimum 75%, Missing); kidney: 68.8742% (minimum 70%, Approved); midbrain: 67.0968% (minimum 75%, Missing); pituitary gland: 38.0952% (minimum 75%, Missing); retina: 27.0833% (minimum 75%, Missing); spinal cord: 64.5963% (minimum 75%, Missing)",0.153623,0.0482014,-0.479167,0,2,partial,28,3.5,3.4,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 2); lung: 4.3 nTPM (vital, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109771,LRP2BP,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.1006% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); cerebellum: 45.2174% (minimum 75%, Missing); cerebral cortex: 58.7571% (minimum 75%, Missing); choroid plexus: 74.2857% (minimum 75%, Missing); heart muscle: 74.8201% (minimum 75%, Missing); hippocampal formation: 55.9140% (minimum 75%, Missing); hypothalamus: 53.8860% (minimum 75%, Missing); kidney: 68.8742% (minimum 70%, Approved); midbrain: 67.0968% (minimum 75%, Missing); pituitary gland: 38.0952% (minimum 75%, Missing); retina: 27.0833% (minimum 75%, Missing); spinal cord: 64.5963% (minimum 75%, Missing)",0.153623,0.0482014,-0.479167,0,2,partial,28,3.5,3.4,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 2); lung: 4.3 nTPM (vital, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109771,LRP2BP,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.1006% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); cerebellum: 45.2174% (minimum 75%, Missing); cerebral cortex: 58.7571% (minimum 75%, Missing); choroid plexus: 74.2857% (minimum 75%, Missing); heart muscle: 74.8201% (minimum 75%, Missing); hippocampal formation: 55.9140% (minimum 75%, Missing); hypothalamus: 53.8860% (minimum 75%, Missing); kidney: 68.8742% (minimum 70%, Approved); midbrain: 67.0968% (minimum 75%, Missing); pituitary gland: 38.0952% (minimum 75%, Missing); retina: 27.0833% (minimum 75%, Missing); spinal cord: 64.5963% (minimum 75%, Missing)",0.153623,0.0482014,-0.479167,0,2,partial,28,3.5,3.4,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 2); lung: 4.3 nTPM (vital, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109771,LRP2BP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.1006% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.5217% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 45.2174% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.7571% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.2857% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 74.8201% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.9140% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.8860% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.8742% (minimum 75%, Baseline (adaptation disabled)); lung: 70.7483% (minimum 75%, Baseline (adaptation disabled)); midbrain: 67.0968% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 38.0952% (minimum 75%, Baseline (adaptation disabled)); retina: 27.0833% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.5963% (minimum 75%, Baseline (adaptation disabled))",0.103623,0.0482014,-0.479167,0,2,partial,28,3.5,3.4,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109771,LRP2BP,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 87.0588% (minimum 99%, Missing); basal ganglia: 80.4348% (minimum 99%, Missing); cerebellum: 84.9761% (minimum 95%, Enhanced); cerebral cortex: 80.1444% (minimum 99%, Missing); choroid plexus: 98.5572% (minimum 99%, Missing); hippocampal formation: 87.7470% (minimum 99%, Missing); hypothalamus: 82.5279% (minimum 99%, Missing); midbrain: 88.4462% (minimum 99%, Missing); pituitary gland: 85.9632% (minimum 99%, Missing); retina: 80.7273% (minimum 99%, Missing); spinal cord: 94.9733% (minimum 99%, Missing)",0.0432886,0.0288751,-0.188556,0,4,partial,22,1.6,4.6,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 6); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109832,DDX25,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343289,0.298875,0.051444,0,4,partial,22,1.6,4.6,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 6); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109832,DDX25,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343289,0.298875,0.051444,0,4,partial,22,1.6,4.6,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 6); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109832,DDX25,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343289,0.298875,0.051444,0,4,partial,22,1.6,4.6,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 6); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109832,DDX25,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.300749,0.282301,0.051444,0,4,partial,22,1.6,4.6,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109832,DDX25,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109851,DBX1,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109851,DBX1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109851,DBX1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109851,DBX1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109851,DBX1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.7593% (minimum 95%, Missing); adrenal gland: 90.2857% (minimum 99%, Missing); amygdala: 85.2518% (minimum 99%, Missing); basal ganglia: 82.4348% (minimum 99%, Missing); bone marrow: 77.7049% (minimum 99%, Missing); cerebellum: 94.2346% (minimum 99%, Missing); cerebral cortex: 84.1918% (minimum 99%, Missing); choroid plexus: 68.5962% (minimum 99%, Missing); colon: 84.7943% (minimum 97%, Missing); duodenum: 82.0069% (minimum 99%, Missing); esophagus: 89.9431% (minimum 97%, Missing); heart muscle: 93.4911% (minimum 99%, Missing); hippocampal formation: 85.2518% (minimum 99%, Missing); hypothalamus: 87.6155% (minimum 99%, Missing); kidney: 90.8046% (minimum 99%, Missing); liver: 91.3295% (minimum 99%, Missing); lung: 95.3722% (minimum 99%, Missing); lymph node: 88.1041% (minimum 97%, Missing); midbrain: 90.6310% (minimum 99%, Missing); pancreas: 91.8605% (minimum 99%, Missing); parathyroid gland: 85.8696% (minimum 97%, Missing); pituitary gland: 89.7727% (minimum 99%, Missing); rectum: 82.8671% (minimum 97%, Missing); retina: 88.7640% (minimum 99%, Missing); salivary gland: 92.2179% (minimum 97%, Missing); skeletal muscle: 94.0476% (minimum 99%, Missing); skin: 88.2682% (minimum 95%, Missing); small intestine: 84.4920% (minimum 99%, Missing); smooth muscle: 93.4911% (minimum 99%, Missing); spinal cord: 91.8605% (minimum 99%, Missing); spleen: 91.8605% (minimum 95%, Missing); stomach: 84.0426% (minimum 97%, Missing); thymus: 75.4777% (minimum 95%, Missing); thyroid gland: 89.7727% (minimum 95%, Missing); tongue: 93.6759% (minimum 97%, Missing); urinary bladder: 93.6759% (minimum 97%, Missing)",-0.195223,-0.141329,-0.304038,0,80,unavailable,21.7,9.8,15.4,"choroid plexus: 21.7 nTPM (vital, limit 1); thymus: 15.4 nTPM (manageable, limit 5); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 2); stomach: 9 nTPM (protected, limit 2); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 2); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); retina: 6 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 2); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); urinary bladder: 3.2 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109881,CCDC34,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.5962% (minimum 75%, Missing)",0.104777,0.128671,-0.0640376,0,80,unavailable,21.7,9.8,15.4,"choroid plexus: 21.7 nTPM (vital, limit 1); thymus: 15.4 nTPM (manageable, limit 5); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 2); stomach: 9 nTPM (protected, limit 2); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 2); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); retina: 6 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 2); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); urinary bladder: 3.2 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109881,CCDC34,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.5962% (minimum 75%, Missing)",0.104777,0.128671,-0.0640376,0,80,unavailable,21.7,9.8,15.4,"choroid plexus: 21.7 nTPM (vital, limit 1); thymus: 15.4 nTPM (manageable, limit 5); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 3); stomach: 9 nTPM (protected, limit 3); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 3); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 3); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); retina: 6 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 3); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); urinary bladder: 3.2 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109881,CCDC34,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.5962% (minimum 75%, Missing)",0.104777,0.128671,-0.0640376,0,80,unavailable,21.7,9.8,15.4,"choroid plexus: 21.7 nTPM (vital, limit 1); thymus: 15.4 nTPM (manageable, limit 5); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 3); stomach: 9 nTPM (protected, limit 3); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 3); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 3); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); retina: 6 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 3); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); urinary bladder: 3.2 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109881,CCDC34,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.5962% (minimum 75%, Baseline (adaptation disabled))",0.104777,0.128671,-0.0640376,0,80,unavailable,21.7,9.8,15.4,"choroid plexus: 21.7 nTPM (vital, limit 1); thymus: 15.4 nTPM (manageable, limit 5); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 3); stomach: 9 nTPM (protected, limit 3); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 3); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 3); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); retina: 6 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 3); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); urinary bladder: 3.2 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109881,CCDC34,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.7273% (minimum 95%, Missing); adrenal gland: 61.5385% (minimum 98%, Approved); amygdala: 57.1429% (minimum 99%, Missing); basal ganglia: 34.7826% (minimum 99%, Missing); bone marrow: 80.0000% (minimum 98%, Approved); cerebellum: 36.3636% (minimum 98%, Approved); cerebral cortex: 32.0000% (minimum 98%, Approved); choroid plexus: 38.0952% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 88.8889% (minimum 99%, Missing); esophagus: 88.8889% (minimum 97%, Missing); heart muscle: 42.1053% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 40.0000% (minimum 99%, Missing); kidney: 61.5385% (minimum 99%, Missing); liver: 66.6667% (minimum 98%, Approved); lung: 66.6667% (minimum 99%, Missing); lymph node: 88.8889% (minimum 95%, Approved); midbrain: 53.3333% (minimum 99%, Missing); pancreas: 72.7273% (minimum 99%, Missing); parathyroid gland: 50.0000% (minimum 95%, Approved); pituitary gland: 38.0952% (minimum 99%, Missing); rectum: 88.8889% (minimum 95%, Approved); retina: 42.1053% (minimum 99%, Missing); salivary gland: 72.7273% (minimum 95%, Approved); skeletal muscle: 53.3333% (minimum 98%, Approved); skin: 88.8889% (minimum 95%, Missing); small intestine: 80.0000% (minimum 98%, Approved); smooth muscle: 80.0000% (minimum 98%, Approved); spinal cord: 57.1429% (minimum 99%, Missing); spleen: 72.7273% (minimum 90%, Approved); stomach: 72.7273% (minimum 95%, Approved); thymus: 80.0000% (minimum 95%, Missing); thyroid gland: 53.3333% (minimum 90%, Approved); tongue: 72.7273% (minimum 97%, Missing); urinary bladder: 72.7273% (minimum 95%, Approved)",-0.366667,-0.45,-0.66,0,3,partial,1.7,0.8,0.7,"basal ganglia: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109927,TECTA,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.5385% (minimum 70%, Approved); amygdala: 57.1429% (minimum 75%, Missing); basal ganglia: 34.7826% (minimum 75%, Missing); cerebellum: 36.3636% (minimum 70%, Approved); cerebral cortex: 32.0000% (minimum 70%, Approved); choroid plexus: 38.0952% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); heart muscle: 42.1053% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 40.0000% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); liver: 66.6667% (minimum 70%, Approved); lung: 66.6667% (minimum 75%, Missing); midbrain: 53.3333% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 65%, Approved); pituitary gland: 38.0952% (minimum 75%, Missing); retina: 42.1053% (minimum 75%, Missing); skeletal muscle: 53.3333% (minimum 70%, Approved); spinal cord: 57.1429% (minimum 75%, Missing); thyroid gland: 53.3333% (minimum 60%, Approved)",-0.0666667,-0.15,-0.402174,0,3,partial,1.7,0.8,0.7,"basal ganglia: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109927,TECTA,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.5385% (minimum 70%, Approved); amygdala: 57.1429% (minimum 75%, Missing); basal ganglia: 34.7826% (minimum 75%, Missing); cerebellum: 36.3636% (minimum 70%, Approved); cerebral cortex: 32.0000% (minimum 70%, Approved); choroid plexus: 38.0952% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); heart muscle: 42.1053% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 40.0000% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); liver: 66.6667% (minimum 70%, Approved); lung: 66.6667% (minimum 75%, Missing); midbrain: 53.3333% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 65%, Approved); pituitary gland: 38.0952% (minimum 75%, Missing); retina: 42.1053% (minimum 75%, Missing); skeletal muscle: 53.3333% (minimum 70%, Approved); spinal cord: 57.1429% (minimum 75%, Missing); thyroid gland: 53.3333% (minimum 60%, Approved)",-0.0666667,-0.15,-0.402174,0,3,partial,1.7,0.8,0.7,"basal ganglia: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109927,TECTA,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.5385% (minimum 70%, Approved); amygdala: 57.1429% (minimum 75%, Missing); basal ganglia: 34.7826% (minimum 75%, Missing); cerebellum: 36.3636% (minimum 70%, Approved); cerebral cortex: 32.0000% (minimum 70%, Approved); choroid plexus: 38.0952% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); heart muscle: 42.1053% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 40.0000% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); liver: 66.6667% (minimum 70%, Approved); lung: 66.6667% (minimum 75%, Missing); midbrain: 53.3333% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 65%, Approved); pituitary gland: 38.0952% (minimum 75%, Missing); retina: 42.1053% (minimum 75%, Missing); skeletal muscle: 53.3333% (minimum 70%, Approved); spinal cord: 57.1429% (minimum 75%, Missing); thyroid gland: 53.3333% (minimum 60%, Approved)",-0.0666667,-0.15,-0.402174,0,3,partial,1.7,0.8,0.7,"basal ganglia: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109927,TECTA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.5385% (minimum 75%, Baseline (adaptation disabled)); amygdala: 57.1429% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 34.7826% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 36.3636% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 32.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 38.0952% (minimum 75%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 42.1053% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 40.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.5385% (minimum 75%, Baseline (adaptation disabled)); liver: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lung: 66.6667% (minimum 75%, Baseline (adaptation disabled)); midbrain: 53.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.7273% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.0000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 38.0952% (minimum 75%, Baseline (adaptation disabled)); retina: 42.1053% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 53.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.1429% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 53.3333% (minimum 65%, Baseline (adaptation disabled))",-0.116667,-0.2,-0.43,0,3,partial,1.7,0.8,0.7,"cerebral cortex: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000109927,TECTA,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1435% (minimum 80%, Supported); adrenal gland: 47.8599% (minimum 99%, Missing); amygdala: 66.3073% (minimum 99%, Missing); basal ganglia: 57.6112% (minimum 99%, Missing); bone marrow: 39.0476% (minimum 99%, Missing); cerebellum: 83.6735% (minimum 99%, Missing); cerebral cortex: 64.9077% (minimum 99%, Missing); choroid plexus: 56.5517% (minimum 99%, Missing); colon: 27.3942% (minimum 97%, Missing); duodenum: 26.3666% (minimum 99%, Missing); esophagus: 53.5948% (minimum 97%, Missing); heart muscle: 50.0000% (minimum 99%, Missing); hippocampal formation: 71.9298% (minimum 99%, Missing); hypothalamus: 72.5664% (minimum 99%, Missing); kidney: 39.8703% (minimum 99%, Missing); liver: 27.1823% (minimum 99%, Missing); lung: 50.0000% (minimum 99%, Missing); lymph node: 61.3466% (minimum 97%, Missing); midbrain: 64.2298% (minimum 99%, Missing); pancreas: 51.7895% (minimum 99%, Missing); parathyroid gland: 47.9532% (minimum 97%, Missing); pituitary gland: 63.7306% (minimum 99%, Missing); rectum: 36.2832% (minimum 97%, Missing); retina: 52.9032% (minimum 99%, Missing); salivary gland: 49.3976% (minimum 97%, Missing); skeletal muscle: 71.9298% (minimum 99%, Missing); skin: 60.0000% (minimum 95%, Missing); small intestine: 26.1981% (minimum 99%, Missing); smooth muscle: 42.2680% (minimum 99%, Missing); spinal cord: 80.3922% (minimum 99%, Missing); spleen: 47.9532% (minimum 95%, Missing); stomach: 41.4840% (minimum 97%, Missing); thymus: 64.3979% (minimum 95%, Missing); thyroid gland: 62.1212% (minimum 95%, Missing); tongue: 64.2298% (minimum 97%, Missing); urinary bladder: 57.6112% (minimum 97%, Missing)",-0.470468,-0.696058,-0.728019,0,6,partial,69.3,65.2,26.7,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 2); rectum: 43.2 nTPM (protected, limit 2); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 2); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); parathyroid gland: 26.7 nTPM (protected, limit 2); salivary gland: 25.2 nTPM (protected, limit 2); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (manageable, limit 15); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); esophagus: 21.3 nTPM (protected, limit 2); choroid plexus: 18.9 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 2); basal ganglia: 18.1 nTPM (vital, limit 1); skin: 16.4 nTPM (manageable, limit 5); lymph node: 15.5 nTPM (protected, limit 2); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 2); midbrain: 13.7 nTPM (vital, limit 1); thymus: 13.6 nTPM (manageable, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110090,CPT1A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1435% (minimum 55%, Supported); adrenal gland: 47.8599% (minimum 75%, Missing); amygdala: 66.3073% (minimum 75%, Missing); basal ganglia: 57.6112% (minimum 75%, Missing); bone marrow: 39.0476% (minimum 75%, Missing); cerebral cortex: 64.9077% (minimum 75%, Missing); choroid plexus: 56.5517% (minimum 75%, Missing); colon: 27.3942% (minimum 70%, Missing); duodenum: 26.3666% (minimum 75%, Missing); esophagus: 53.5948% (minimum 70%, Missing); heart muscle: 50.0000% (minimum 75%, Missing); hippocampal formation: 71.9298% (minimum 75%, Missing); hypothalamus: 72.5664% (minimum 75%, Missing); kidney: 39.8703% (minimum 75%, Missing); liver: 27.1823% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 61.3466% (minimum 70%, Missing); midbrain: 64.2298% (minimum 75%, Missing); pancreas: 51.7895% (minimum 75%, Missing); parathyroid gland: 47.9532% (minimum 70%, Missing); pituitary gland: 63.7306% (minimum 75%, Missing); rectum: 36.2832% (minimum 70%, Missing); retina: 52.9032% (minimum 75%, Missing); salivary gland: 49.3976% (minimum 70%, Missing); skeletal muscle: 71.9298% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 26.1981% (minimum 75%, Missing); smooth muscle: 42.2680% (minimum 75%, Missing); spleen: 47.9532% (minimum 65%, Missing); stomach: 41.4840% (minimum 70%, Missing); thymus: 64.3979% (minimum 65%, Missing); thyroid gland: 62.1212% (minimum 65%, Missing); tongue: 64.2298% (minimum 70%, Missing); urinary bladder: 57.6112% (minimum 70%, Missing)",-0.170468,-0.426058,-0.488019,0,6,partial,69.3,65.2,26.7,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 2); rectum: 43.2 nTPM (protected, limit 2); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 2); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); parathyroid gland: 26.7 nTPM (protected, limit 2); salivary gland: 25.2 nTPM (protected, limit 2); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (manageable, limit 15); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); esophagus: 21.3 nTPM (protected, limit 2); choroid plexus: 18.9 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 2); basal ganglia: 18.1 nTPM (vital, limit 1); skin: 16.4 nTPM (manageable, limit 5); lymph node: 15.5 nTPM (protected, limit 2); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 2); midbrain: 13.7 nTPM (vital, limit 1); thymus: 13.6 nTPM (manageable, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110090,CPT1A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1435% (minimum 55%, Supported); adrenal gland: 47.8599% (minimum 75%, Missing); amygdala: 66.3073% (minimum 75%, Missing); basal ganglia: 57.6112% (minimum 75%, Missing); bone marrow: 39.0476% (minimum 75%, Missing); cerebral cortex: 64.9077% (minimum 75%, Missing); choroid plexus: 56.5517% (minimum 75%, Missing); colon: 27.3942% (minimum 70%, Missing); duodenum: 26.3666% (minimum 75%, Missing); esophagus: 53.5948% (minimum 70%, Missing); heart muscle: 50.0000% (minimum 75%, Missing); hippocampal formation: 71.9298% (minimum 75%, Missing); hypothalamus: 72.5664% (minimum 75%, Missing); kidney: 39.8703% (minimum 75%, Missing); liver: 27.1823% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 61.3466% (minimum 70%, Missing); midbrain: 64.2298% (minimum 75%, Missing); pancreas: 51.7895% (minimum 75%, Missing); parathyroid gland: 47.9532% (minimum 70%, Missing); pituitary gland: 63.7306% (minimum 75%, Missing); rectum: 36.2832% (minimum 70%, Missing); retina: 52.9032% (minimum 75%, Missing); salivary gland: 49.3976% (minimum 70%, Missing); skeletal muscle: 71.9298% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 26.1981% (minimum 75%, Missing); smooth muscle: 42.2680% (minimum 75%, Missing); spleen: 47.9532% (minimum 65%, Missing); stomach: 41.4840% (minimum 70%, Missing); thymus: 64.3979% (minimum 65%, Missing); thyroid gland: 62.1212% (minimum 65%, Missing); tongue: 64.2298% (minimum 70%, Missing); urinary bladder: 57.6112% (minimum 70%, Missing)",-0.170468,-0.426058,-0.488019,0,6,partial,69.3,65.2,26.7,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 3); rectum: 43.2 nTPM (protected, limit 3); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 3); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); parathyroid gland: 26.7 nTPM (protected, limit 3); salivary gland: 25.2 nTPM (protected, limit 3); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (manageable, limit 15); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); esophagus: 21.3 nTPM (protected, limit 3); choroid plexus: 18.9 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 3); basal ganglia: 18.1 nTPM (vital, limit 1); skin: 16.4 nTPM (manageable, limit 5); lymph node: 15.5 nTPM (protected, limit 3); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 3); midbrain: 13.7 nTPM (vital, limit 1); thymus: 13.6 nTPM (manageable, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110090,CPT1A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1435% (minimum 55%, Supported); adrenal gland: 47.8599% (minimum 75%, Missing); amygdala: 66.3073% (minimum 75%, Missing); basal ganglia: 57.6112% (minimum 75%, Missing); bone marrow: 39.0476% (minimum 75%, Missing); cerebral cortex: 64.9077% (minimum 75%, Missing); choroid plexus: 56.5517% (minimum 75%, Missing); colon: 27.3942% (minimum 70%, Missing); duodenum: 26.3666% (minimum 75%, Missing); esophagus: 53.5948% (minimum 70%, Missing); heart muscle: 50.0000% (minimum 75%, Missing); hippocampal formation: 71.9298% (minimum 75%, Missing); hypothalamus: 72.5664% (minimum 75%, Missing); kidney: 39.8703% (minimum 75%, Missing); liver: 27.1823% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 61.3466% (minimum 70%, Missing); midbrain: 64.2298% (minimum 75%, Missing); pancreas: 51.7895% (minimum 75%, Missing); parathyroid gland: 47.9532% (minimum 70%, Missing); pituitary gland: 63.7306% (minimum 75%, Missing); rectum: 36.2832% (minimum 70%, Missing); retina: 52.9032% (minimum 75%, Missing); salivary gland: 49.3976% (minimum 70%, Missing); skeletal muscle: 71.9298% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 26.1981% (minimum 75%, Missing); smooth muscle: 42.2680% (minimum 75%, Missing); spleen: 47.9532% (minimum 65%, Missing); stomach: 41.4840% (minimum 70%, Missing); thymus: 64.3979% (minimum 65%, Missing); thyroid gland: 62.1212% (minimum 65%, Missing); tongue: 64.2298% (minimum 70%, Missing); urinary bladder: 57.6112% (minimum 70%, Missing)",-0.170468,-0.426058,-0.488019,0,6,partial,69.3,65.2,26.7,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 3); rectum: 43.2 nTPM (protected, limit 3); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 3); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); parathyroid gland: 26.7 nTPM (protected, limit 3); salivary gland: 25.2 nTPM (protected, limit 3); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (manageable, limit 15); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); esophagus: 21.3 nTPM (protected, limit 3); choroid plexus: 18.9 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 3); basal ganglia: 18.1 nTPM (vital, limit 1); skin: 16.4 nTPM (manageable, limit 5); lymph node: 15.5 nTPM (protected, limit 3); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 3); midbrain: 13.7 nTPM (vital, limit 1); thymus: 13.6 nTPM (manageable, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110090,CPT1A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1435% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 47.8599% (minimum 75%, Baseline (adaptation disabled)); amygdala: 66.3073% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 57.6112% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 39.0476% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.9077% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 56.5517% (minimum 75%, Baseline (adaptation disabled)); colon: 27.3942% (minimum 70%, Baseline (adaptation disabled)); duodenum: 26.3666% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.5948% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.9298% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.5664% (minimum 75%, Baseline (adaptation disabled)); kidney: 39.8703% (minimum 75%, Baseline (adaptation disabled)); liver: 27.1823% (minimum 75%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.3466% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.2298% (minimum 75%, Baseline (adaptation disabled)); pancreas: 51.7895% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 47.9532% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.7306% (minimum 75%, Baseline (adaptation disabled)); rectum: 36.2832% (minimum 70%, Baseline (adaptation disabled)); retina: 52.9032% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 49.3976% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 71.9298% (minimum 75%, Baseline (adaptation disabled)); skin: 60.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 26.1981% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 42.2680% (minimum 75%, Baseline (adaptation disabled)); spleen: 47.9532% (minimum 65%, Baseline (adaptation disabled)); stomach: 41.4840% (minimum 70%, Baseline (adaptation disabled)); thymus: 64.3979% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.1212% (minimum 65%, Baseline (adaptation disabled)); tongue: 64.2298% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.6112% (minimum 70%, Baseline (adaptation disabled))",-0.170468,-0.426058,-0.488019,0,6,partial,69.3,65.2,26.7,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 3); rectum: 43.2 nTPM (protected, limit 3); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 3); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); parathyroid gland: 26.7 nTPM (protected, limit 3); salivary gland: 25.2 nTPM (protected, limit 3); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (manageable, limit 5); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); esophagus: 21.3 nTPM (protected, limit 3); choroid plexus: 18.9 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 3); basal ganglia: 18.1 nTPM (vital, limit 1); skin: 16.4 nTPM (manageable, limit 5); lymph node: 15.5 nTPM (protected, limit 3); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 3); midbrain: 13.7 nTPM (vital, limit 1); thymus: 13.6 nTPM (manageable, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110090,CPT1A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 37.7926% (minimum 90%, Approved); adrenal gland: 61.9744% (minimum 99%, Missing); amygdala: 76.1798% (minimum 99%, Missing); basal ganglia: 77.5744% (minimum 99%, Missing); bone marrow: 59.4737% (minimum 99%, Missing); cerebellum: 74.8344% (minimum 99%, Missing); cerebral cortex: 71.9745% (minimum 99%, Missing); choroid plexus: 64.0832% (minimum 99%, Missing); colon: 53.3019% (minimum 97%, Missing); duodenum: 67.6647% (minimum 99%, Missing); esophagus: 53.2182% (minimum 97%, Missing); heart muscle: 39.5566% (minimum 99%, Missing); hippocampal formation: 76.1798% (minimum 99%, Missing); hypothalamus: 74.0175% (minimum 99%, Missing); kidney: 47.9491% (minimum 99%, Missing); liver: 53.9809% (minimum 99%, Missing); lung: 56.5000% (minimum 99%, Missing); lymph node: 60.3203% (minimum 97%, Missing); midbrain: 74.1794% (minimum 99%, Missing); pancreas: 57.5552% (minimum 99%, Missing); parathyroid gland: 42.8571% (minimum 97%, Missing); pituitary gland: 73.0603% (minimum 99%, Missing); rectum: 63.0112% (minimum 97%, Missing); retina: 60.9712% (minimum 99%, Missing); salivary gland: 60.3203% (minimum 97%, Missing); skeletal muscle: 33.7649% (minimum 99%, Missing); skin: 60.9712% (minimum 95%, Missing); small intestine: 63.2463% (minimum 99%, Missing); smooth muscle: 47.2145% (minimum 99%, Missing); spinal cord: 67.5299% (minimum 99%, Missing); spleen: 53.2182% (minimum 95%, Missing); stomach: 61.3020% (minimum 97%, Missing); thymus: 57.7513% (minimum 95%, Missing); thyroid gland: 50.9009% (minimum 95%, Missing); tongue: 29.2494% (minimum 97%, Missing); urinary bladder: 52.0737% (minimum 97%, Missing)",-0.522074,-0.677506,-0.652351,0,3,partial,66.5,82,55.8,"tongue: 82 nTPM (protected, limit 2); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (manageable, limit 10); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 2); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (manageable, limit 5); urinary bladder: 31.2 nTPM (protected, limit 2); esophagus: 29.8 nTPM (protected, limit 2); spleen: 29.8 nTPM (manageable, limit 5); colon: 29.7 nTPM (protected, limit 2); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); thymus: 24.8 nTPM (manageable, limit 5); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 2); salivary gland: 22.3 nTPM (protected, limit 2); skin: 21.7 nTPM (manageable, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 2); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 2); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110422,HIPK3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 37.7926% (minimum 60%, Approved); adrenal gland: 61.9744% (minimum 75%, Missing); bone marrow: 59.4737% (minimum 75%, Missing); cerebellum: 74.8344% (minimum 75%, Missing); cerebral cortex: 71.9745% (minimum 75%, Missing); choroid plexus: 64.0832% (minimum 75%, Missing); colon: 53.3019% (minimum 70%, Missing); duodenum: 67.6647% (minimum 75%, Missing); esophagus: 53.2182% (minimum 70%, Missing); heart muscle: 39.5566% (minimum 75%, Missing); hypothalamus: 74.0175% (minimum 75%, Missing); kidney: 47.9491% (minimum 75%, Missing); liver: 53.9809% (minimum 75%, Missing); lung: 56.5000% (minimum 75%, Missing); lymph node: 60.3203% (minimum 70%, Missing); midbrain: 74.1794% (minimum 75%, Missing); pancreas: 57.5552% (minimum 75%, Missing); parathyroid gland: 42.8571% (minimum 70%, Missing); pituitary gland: 73.0603% (minimum 75%, Missing); rectum: 63.0112% (minimum 70%, Missing); retina: 60.9712% (minimum 75%, Missing); salivary gland: 60.3203% (minimum 70%, Missing); skeletal muscle: 33.7649% (minimum 75%, Missing); skin: 60.9712% (minimum 65%, Missing); small intestine: 63.2463% (minimum 75%, Missing); smooth muscle: 47.2145% (minimum 75%, Missing); spinal cord: 67.5299% (minimum 75%, Missing); spleen: 53.2182% (minimum 65%, Missing); stomach: 61.3020% (minimum 70%, Missing); thymus: 57.7513% (minimum 65%, Missing); thyroid gland: 50.9009% (minimum 65%, Missing); tongue: 29.2494% (minimum 70%, Missing); urinary bladder: 52.0737% (minimum 70%, Missing)",-0.222074,-0.407506,-0.412351,0,3,partial,66.5,82,55.8,"tongue: 82 nTPM (protected, limit 2); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (manageable, limit 10); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 2); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (manageable, limit 5); urinary bladder: 31.2 nTPM (protected, limit 2); esophagus: 29.8 nTPM (protected, limit 2); spleen: 29.8 nTPM (manageable, limit 5); colon: 29.7 nTPM (protected, limit 2); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); thymus: 24.8 nTPM (manageable, limit 5); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 2); salivary gland: 22.3 nTPM (protected, limit 2); skin: 21.7 nTPM (manageable, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 2); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 2); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110422,HIPK3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 37.7926% (minimum 60%, Approved); adrenal gland: 61.9744% (minimum 75%, Missing); bone marrow: 59.4737% (minimum 75%, Missing); cerebellum: 74.8344% (minimum 75%, Missing); cerebral cortex: 71.9745% (minimum 75%, Missing); choroid plexus: 64.0832% (minimum 75%, Missing); colon: 53.3019% (minimum 70%, Missing); duodenum: 67.6647% (minimum 75%, Missing); esophagus: 53.2182% (minimum 70%, Missing); heart muscle: 39.5566% (minimum 75%, Missing); hypothalamus: 74.0175% (minimum 75%, Missing); kidney: 47.9491% (minimum 75%, Missing); liver: 53.9809% (minimum 75%, Missing); lung: 56.5000% (minimum 75%, Missing); lymph node: 60.3203% (minimum 70%, Missing); midbrain: 74.1794% (minimum 75%, Missing); pancreas: 57.5552% (minimum 75%, Missing); parathyroid gland: 42.8571% (minimum 70%, Missing); pituitary gland: 73.0603% (minimum 75%, Missing); rectum: 63.0112% (minimum 70%, Missing); retina: 60.9712% (minimum 75%, Missing); salivary gland: 60.3203% (minimum 70%, Missing); skeletal muscle: 33.7649% (minimum 75%, Missing); skin: 60.9712% (minimum 65%, Missing); small intestine: 63.2463% (minimum 75%, Missing); smooth muscle: 47.2145% (minimum 75%, Missing); spinal cord: 67.5299% (minimum 75%, Missing); spleen: 53.2182% (minimum 65%, Missing); stomach: 61.3020% (minimum 70%, Missing); thymus: 57.7513% (minimum 65%, Missing); thyroid gland: 50.9009% (minimum 65%, Missing); tongue: 29.2494% (minimum 70%, Missing); urinary bladder: 52.0737% (minimum 70%, Missing)",-0.222074,-0.407506,-0.412351,0,3,partial,66.5,82,55.8,"tongue: 82 nTPM (protected, limit 3); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (manageable, limit 10); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 3); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (manageable, limit 5); urinary bladder: 31.2 nTPM (protected, limit 3); esophagus: 29.8 nTPM (protected, limit 3); spleen: 29.8 nTPM (manageable, limit 5); colon: 29.7 nTPM (protected, limit 3); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); thymus: 24.8 nTPM (manageable, limit 5); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 3); salivary gland: 22.3 nTPM (protected, limit 3); skin: 21.7 nTPM (manageable, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 3); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 3); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110422,HIPK3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 37.7926% (minimum 60%, Approved); adrenal gland: 61.9744% (minimum 75%, Missing); bone marrow: 59.4737% (minimum 75%, Missing); cerebellum: 74.8344% (minimum 75%, Missing); cerebral cortex: 71.9745% (minimum 75%, Missing); choroid plexus: 64.0832% (minimum 75%, Missing); colon: 53.3019% (minimum 70%, Missing); duodenum: 67.6647% (minimum 75%, Missing); esophagus: 53.2182% (minimum 70%, Missing); heart muscle: 39.5566% (minimum 75%, Missing); hypothalamus: 74.0175% (minimum 75%, Missing); kidney: 47.9491% (minimum 75%, Missing); liver: 53.9809% (minimum 75%, Missing); lung: 56.5000% (minimum 75%, Missing); lymph node: 60.3203% (minimum 70%, Missing); midbrain: 74.1794% (minimum 75%, Missing); pancreas: 57.5552% (minimum 75%, Missing); parathyroid gland: 42.8571% (minimum 70%, Missing); pituitary gland: 73.0603% (minimum 75%, Missing); rectum: 63.0112% (minimum 70%, Missing); retina: 60.9712% (minimum 75%, Missing); salivary gland: 60.3203% (minimum 70%, Missing); skeletal muscle: 33.7649% (minimum 75%, Missing); skin: 60.9712% (minimum 65%, Missing); small intestine: 63.2463% (minimum 75%, Missing); smooth muscle: 47.2145% (minimum 75%, Missing); spinal cord: 67.5299% (minimum 75%, Missing); spleen: 53.2182% (minimum 65%, Missing); stomach: 61.3020% (minimum 70%, Missing); thymus: 57.7513% (minimum 65%, Missing); thyroid gland: 50.9009% (minimum 65%, Missing); tongue: 29.2494% (minimum 70%, Missing); urinary bladder: 52.0737% (minimum 70%, Missing)",-0.222074,-0.407506,-0.412351,0,3,partial,66.5,82,55.8,"tongue: 82 nTPM (protected, limit 3); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (manageable, limit 10); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 3); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (manageable, limit 5); urinary bladder: 31.2 nTPM (protected, limit 3); esophagus: 29.8 nTPM (protected, limit 3); spleen: 29.8 nTPM (manageable, limit 5); colon: 29.7 nTPM (protected, limit 3); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); thymus: 24.8 nTPM (manageable, limit 5); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 3); salivary gland: 22.3 nTPM (protected, limit 3); skin: 21.7 nTPM (manageable, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 3); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 3); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110422,HIPK3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 37.7926% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 61.9744% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 59.4737% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.8344% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 71.9745% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.0832% (minimum 75%, Baseline (adaptation disabled)); colon: 53.3019% (minimum 70%, Baseline (adaptation disabled)); duodenum: 67.6647% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.2182% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 39.5566% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.0175% (minimum 75%, Baseline (adaptation disabled)); kidney: 47.9491% (minimum 75%, Baseline (adaptation disabled)); liver: 53.9809% (minimum 75%, Baseline (adaptation disabled)); lung: 56.5000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.3203% (minimum 70%, Baseline (adaptation disabled)); midbrain: 74.1794% (minimum 75%, Baseline (adaptation disabled)); pancreas: 57.5552% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 42.8571% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 73.0603% (minimum 75%, Baseline (adaptation disabled)); rectum: 63.0112% (minimum 70%, Baseline (adaptation disabled)); retina: 60.9712% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.3203% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 33.7649% (minimum 75%, Baseline (adaptation disabled)); skin: 60.9712% (minimum 65%, Baseline (adaptation disabled)); small intestine: 63.2463% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 47.2145% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.5299% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.2182% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.3020% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.7513% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.9009% (minimum 65%, Baseline (adaptation disabled)); tongue: 29.2494% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.0737% (minimum 70%, Baseline (adaptation disabled))",-0.272074,-0.407506,-0.412351,0,3,partial,66.5,82,55.8,"tongue: 82 nTPM (protected, limit 3); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (manageable, limit 5); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 3); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (manageable, limit 5); urinary bladder: 31.2 nTPM (protected, limit 3); esophagus: 29.8 nTPM (protected, limit 3); spleen: 29.8 nTPM (manageable, limit 5); colon: 29.7 nTPM (protected, limit 3); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); thymus: 24.8 nTPM (manageable, limit 5); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 3); salivary gland: 22.3 nTPM (protected, limit 3); skin: 21.7 nTPM (manageable, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 3); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 3); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110422,HIPK3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.1026% (minimum 95%, Missing); adrenal gland: 91.4474% (minimum 95%, Enhanced); amygdala: 79.8851% (minimum 99%, Missing); basal ganglia: 81.2865% (minimum 99%, Missing); bone marrow: 34.4059% (minimum 99%, Missing); cerebellum: 95.2055% (minimum 99%, Missing); cerebral cortex: 69.5000% (minimum 99%, Missing); choroid plexus: 89.1026% (minimum 99%, Missing); colon: 92.0530% (minimum 97%, Missing); duodenum: 69.1542% (minimum 99%, Missing); heart muscle: 83.2335% (minimum 95%, Enhanced); hippocampal formation: 84.2424% (minimum 99%, Missing); hypothalamus: 84.7561% (minimum 99%, Missing); kidney: 56.7347% (minimum 95%, Enhanced); liver: 75.1351% (minimum 99%, Missing); lung: 94.5578% (minimum 99%, Missing); midbrain: 82.7381% (minimum 99%, Missing); pancreas: 67.8049% (minimum 99%, Missing); pituitary gland: 83.2335% (minimum 99%, Missing); rectum: 92.0530% (minimum 97%, Missing); retina: 82.2485% (minimum 99%, Missing); skeletal muscle: 60.6987% (minimum 99%, Missing); skin: 71.6495% (minimum 95%, Missing); small intestine: 56.5041% (minimum 99%, Missing); spinal cord: 90.2597% (minimum 99%, Missing); stomach: 93.2886% (minimum 97%, Missing); thymus: 90.2597% (minimum 95%, Missing); tongue: 70.9184% (minimum 97%, Missing)",-0.233505,-0.260816,-0.645941,0,15,partial,26.5,5.7,5.5,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 6); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); skin: 5.5 nTPM (manageable, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),87,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / fibrohistiocytic cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110693,SOX6,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 34.4059% (minimum 75%, Missing); cerebral cortex: 69.5000% (minimum 75%, Missing); duodenum: 69.1542% (minimum 75%, Missing); kidney: 56.7347% (minimum 60%, Enhanced); pancreas: 67.8049% (minimum 75%, Missing); skeletal muscle: 60.6987% (minimum 75%, Missing); small intestine: 56.5041% (minimum 75%, Missing)",0.0664948,0.00918367,-0.405941,0,15,partial,26.5,5.7,5.5,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 6); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); skin: 5.5 nTPM (manageable, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),87,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / fibrohistiocytic cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110693,SOX6,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 34.4059% (minimum 75%, Missing); cerebral cortex: 69.5000% (minimum 75%, Missing); duodenum: 69.1542% (minimum 75%, Missing); kidney: 56.7347% (minimum 60%, Enhanced); pancreas: 67.8049% (minimum 75%, Missing); skeletal muscle: 60.6987% (minimum 75%, Missing); small intestine: 56.5041% (minimum 75%, Missing)",0.0664948,0.00918367,-0.405941,0,15,partial,26.5,5.7,5.5,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 6); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); skin: 5.5 nTPM (manageable, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),87,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / fibrohistiocytic cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110693,SOX6,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 34.4059% (minimum 75%, Missing); cerebral cortex: 69.5000% (minimum 75%, Missing); duodenum: 69.1542% (minimum 75%, Missing); kidney: 56.7347% (minimum 60%, Enhanced); pancreas: 67.8049% (minimum 75%, Missing); skeletal muscle: 60.6987% (minimum 75%, Missing); small intestine: 56.5041% (minimum 75%, Missing)",0.0664948,0.00918367,-0.405941,0,15,partial,26.5,5.7,5.5,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 6); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); skin: 5.5 nTPM (manageable, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),87,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / fibrohistiocytic cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110693,SOX6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 34.4059% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 69.5000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 69.1542% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.7347% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.8049% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 60.6987% (minimum 75%, Baseline (adaptation disabled)); small intestine: 56.5041% (minimum 75%, Baseline (adaptation disabled))",0.0664948,0.00918367,-0.405941,0,15,partial,26.5,5.7,5.5,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); skin: 5.5 nTPM (manageable, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),87,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / fibrohistiocytic cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110693,SOX6,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 87.5000% (minimum 99%, Missing); basal ganglia: 84.0000% (minimum 99%, Missing); cerebral cortex: 77.7778% (minimum 99%, Missing); choroid plexus: 95.4545% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 91.3043% (minimum 99%, Missing); hypothalamus: 84.0000% (minimum 99%, Missing); kidney: 72.4138% (minimum 99%, Missing); liver: 87.5000% (minimum 99%, Missing); pituitary gland: 84.0000% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 95.4545% (minimum 99%, Missing); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 95.4545% (minimum 99%, Missing); stomach: 84.0000% (minimum 97%, Missing)",0.05,-0.22,-0.265862,0,80,unavailable,0.8,0.7,0,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110975,SYT10,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 72.4138% (minimum 75%, Missing)",0.35,0.05,-0.0258621,0,80,unavailable,0.8,0.7,0,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110975,SYT10,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 72.4138% (minimum 75%, Missing)",0.35,0.05,-0.0258621,0,80,unavailable,0.8,0.7,0,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110975,SYT10,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 72.4138% (minimum 75%, Missing)",0.35,0.05,-0.0258621,0,80,unavailable,0.8,0.7,0,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110975,SYT10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 72.4138% (minimum 75%, Baseline (adaptation disabled))",0.35,0.05,-0.0258621,0,80,unavailable,0.8,0.7,0,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000110975,SYT10,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5954% (minimum 90%, Approved); adrenal gland: 73.2143% (minimum 99%, Missing); amygdala: 62.1212% (minimum 99%, Missing); basal ganglia: 65.6000% (minimum 99%, Missing); bone marrow: 22.9050% (minimum 99%, Missing); cerebellum: 29.9270% (minimum 98%, Approved); cerebral cortex: 50.6173% (minimum 98%, Approved); choroid plexus: 76.6355% (minimum 99%, Missing); colon: 81.1881% (minimum 97%, Missing); duodenum: 94.2529% (minimum 99%, Missing); esophagus: 90.1099% (minimum 95%, Approved); heart muscle: 57.3427% (minimum 98%, Approved); hippocampal formation: 63.0769% (minimum 99%, Missing); hypothalamus: 59.4203% (minimum 99%, Missing); kidney: 49.3976% (minimum 99%, Missing); liver: 32.4111% (minimum 99%, Missing); lung: 62.5954% (minimum 98%, Approved); lymph node: 75.9259% (minimum 95%, Approved); midbrain: 63.5659% (minimum 99%, Missing); pancreas: 94.2529% (minimum 98%, Approved); parathyroid gland: 90.1099% (minimum 95%, Approved); pituitary gland: 58.5714% (minimum 99%, Missing); rectum: 94.2529% (minimum 97%, Missing); retina: 24.1176% (minimum 99%, Missing); salivary gland: 91.1111% (minimum 97%, Missing); skeletal muscle: 89.1304% (minimum 98%, Approved); small intestine: 80.3922% (minimum 99%, Missing); smooth muscle: 65.0794% (minimum 99%, Missing); spinal cord: 81.1881% (minimum 99%, Missing); spleen: 64.5669% (minimum 95%, Missing); stomach: 88.1720% (minimum 95%, Approved); thymus: 93.1818% (minimum 95%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); tongue: 77.3585% (minimum 97%, Missing); urinary bladder: 68.3333% (minimum 95%, Approved)",-0.304331,-0.266667,-0.76095,0,4,partial,27.6,3.8,4.9,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 2); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 2); heart muscle: 6.1 nTPM (vital, limit 2); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111052,LIN7A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.2143% (minimum 75%, Missing); amygdala: 62.1212% (minimum 75%, Missing); basal ganglia: 65.6000% (minimum 75%, Missing); bone marrow: 22.9050% (minimum 75%, Missing); cerebellum: 29.9270% (minimum 70%, Approved); cerebral cortex: 50.6173% (minimum 70%, Approved); heart muscle: 57.3427% (minimum 70%, Approved); hippocampal formation: 63.0769% (minimum 75%, Missing); hypothalamus: 59.4203% (minimum 75%, Missing); kidney: 49.3976% (minimum 75%, Missing); liver: 32.4111% (minimum 75%, Missing); lung: 62.5954% (minimum 70%, Approved); midbrain: 63.5659% (minimum 75%, Missing); pituitary gland: 58.5714% (minimum 75%, Missing); retina: 24.1176% (minimum 75%, Missing); smooth muscle: 65.0794% (minimum 75%, Missing); spleen: 64.5669% (minimum 65%, Missing)",-0.00433071,0.0333333,-0.52095,0,4,partial,27.6,3.8,4.9,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 2); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 2); heart muscle: 6.1 nTPM (vital, limit 2); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111052,LIN7A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.2143% (minimum 75%, Missing); amygdala: 62.1212% (minimum 75%, Missing); basal ganglia: 65.6000% (minimum 75%, Missing); bone marrow: 22.9050% (minimum 75%, Missing); cerebellum: 29.9270% (minimum 70%, Approved); cerebral cortex: 50.6173% (minimum 70%, Approved); heart muscle: 57.3427% (minimum 70%, Approved); hippocampal formation: 63.0769% (minimum 75%, Missing); hypothalamus: 59.4203% (minimum 75%, Missing); kidney: 49.3976% (minimum 75%, Missing); liver: 32.4111% (minimum 75%, Missing); lung: 62.5954% (minimum 70%, Approved); midbrain: 63.5659% (minimum 75%, Missing); pituitary gland: 58.5714% (minimum 75%, Missing); retina: 24.1176% (minimum 75%, Missing); smooth muscle: 65.0794% (minimum 75%, Missing); spleen: 64.5669% (minimum 65%, Missing)",-0.00433071,0.0333333,-0.52095,0,4,partial,27.6,3.8,4.9,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 2); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 2); heart muscle: 6.1 nTPM (vital, limit 2); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111052,LIN7A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.2143% (minimum 75%, Missing); amygdala: 62.1212% (minimum 75%, Missing); basal ganglia: 65.6000% (minimum 75%, Missing); bone marrow: 22.9050% (minimum 75%, Missing); cerebellum: 29.9270% (minimum 70%, Approved); cerebral cortex: 50.6173% (minimum 70%, Approved); heart muscle: 57.3427% (minimum 70%, Approved); hippocampal formation: 63.0769% (minimum 75%, Missing); hypothalamus: 59.4203% (minimum 75%, Missing); kidney: 49.3976% (minimum 75%, Missing); liver: 32.4111% (minimum 75%, Missing); lung: 62.5954% (minimum 70%, Approved); midbrain: 63.5659% (minimum 75%, Missing); pituitary gland: 58.5714% (minimum 75%, Missing); retina: 24.1176% (minimum 75%, Missing); smooth muscle: 65.0794% (minimum 75%, Missing); spleen: 64.5669% (minimum 65%, Missing)",-0.00433071,0.0333333,-0.52095,0,4,partial,27.6,3.8,4.9,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 2); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 2); heart muscle: 6.1 nTPM (vital, limit 2); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111052,LIN7A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5954% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 73.2143% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.1212% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.6000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 22.9050% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 29.9270% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.6173% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 57.3427% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.0769% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 59.4203% (minimum 75%, Baseline (adaptation disabled)); kidney: 49.3976% (minimum 75%, Baseline (adaptation disabled)); liver: 32.4111% (minimum 75%, Baseline (adaptation disabled)); lung: 62.5954% (minimum 75%, Baseline (adaptation disabled)); midbrain: 63.5659% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 58.5714% (minimum 75%, Baseline (adaptation disabled)); retina: 24.1176% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.0794% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.5669% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 68.3333% (minimum 70%, Baseline (adaptation disabled))",-0.0240458,-0.0166667,-0.52095,0,4,partial,27.6,3.8,4.9,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); adrenal gland: 3 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111052,LIN7A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.1429% (minimum 95%, Missing); adrenal gland: 88.4058% (minimum 99%, Missing); amygdala: 91.0448% (minimum 99%, Missing); basal ganglia: 91.0448% (minimum 99%, Missing); bone marrow: 26.7544% (minimum 99%, Missing); cerebellum: 89.7059% (minimum 99%, Missing); cerebral cortex: 87.1429% (minimum 99%, Missing); choroid plexus: 96.8254% (minimum 99%, Missing); colon: 54.9550% (minimum 97%, Missing); duodenum: 54.9550% (minimum 99%, Missing); esophagus: 66.3043% (minimum 97%, Missing); heart muscle: 92.4242% (minimum 99%, Missing); hippocampal formation: 91.0448% (minimum 99%, Missing); hypothalamus: 92.4242% (minimum 99%, Missing); kidney: 88.4058% (minimum 99%, Missing); liver: 77.2152% (minimum 99%, Missing); lung: 82.4324% (minimum 99%, Missing); lymph node: 41.2162% (minimum 97%, Missing); midbrain: 87.1429% (minimum 99%, Missing); pancreas: 93.8462% (minimum 99%, Missing); parathyroid gland: 91.0448% (minimum 97%, Missing); pituitary gland: 95.3125% (minimum 99%, Missing); rectum: 49.1935% (minimum 97%, Missing); retina: 80.2632% (minimum 99%, Missing); salivary gland: 85.9155% (minimum 97%, Missing); skeletal muscle: 93.8462% (minimum 99%, Missing); skin: 66.3043% (minimum 95%, Missing); small intestine: 56.4815% (minimum 99%, Missing); smooth muscle: 77.2152% (minimum 99%, Missing); spinal cord: 84.7222% (minimum 99%, Missing); spleen: 64.8936% (minimum 95%, Missing); stomach: 70.1149% (minimum 97%, Missing); thymus: 30.3483% (minimum 95%, Missing); thyroid gland: 85.9155% (minimum 95%, Missing); tongue: 91.0448% (minimum 97%, Missing); urinary bladder: 79.2208% (minimum 97%, Missing)",-0.646517,-0.557838,-0.722456,0,80,unavailable,16.7,8.7,14,"bone marrow: 16.7 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 8.7 nTPM (protected, limit 2); rectum: 6.3 nTPM (protected, limit 2); colon: 5 nTPM (protected, limit 2); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111247,RAD51AP1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.7544% (minimum 75%, Missing); colon: 54.9550% (minimum 70%, Missing); duodenum: 54.9550% (minimum 75%, Missing); esophagus: 66.3043% (minimum 70%, Missing); lymph node: 41.2162% (minimum 70%, Missing); rectum: 49.1935% (minimum 70%, Missing); small intestine: 56.4815% (minimum 75%, Missing); spleen: 64.8936% (minimum 65%, Missing); thymus: 30.3483% (minimum 65%, Missing)",-0.346517,-0.287838,-0.482456,0,80,unavailable,16.7,8.7,14,"bone marrow: 16.7 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 8.7 nTPM (protected, limit 2); rectum: 6.3 nTPM (protected, limit 2); colon: 5 nTPM (protected, limit 2); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111247,RAD51AP1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.7544% (minimum 75%, Missing); colon: 54.9550% (minimum 70%, Missing); duodenum: 54.9550% (minimum 75%, Missing); esophagus: 66.3043% (minimum 70%, Missing); lymph node: 41.2162% (minimum 70%, Missing); rectum: 49.1935% (minimum 70%, Missing); small intestine: 56.4815% (minimum 75%, Missing); spleen: 64.8936% (minimum 65%, Missing); thymus: 30.3483% (minimum 65%, Missing)",-0.346517,-0.287838,-0.482456,0,80,unavailable,16.7,8.7,14,"bone marrow: 16.7 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 8.7 nTPM (protected, limit 3); rectum: 6.3 nTPM (protected, limit 3); colon: 5 nTPM (protected, limit 3); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111247,RAD51AP1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.7544% (minimum 75%, Missing); colon: 54.9550% (minimum 70%, Missing); duodenum: 54.9550% (minimum 75%, Missing); esophagus: 66.3043% (minimum 70%, Missing); lymph node: 41.2162% (minimum 70%, Missing); rectum: 49.1935% (minimum 70%, Missing); small intestine: 56.4815% (minimum 75%, Missing); spleen: 64.8936% (minimum 65%, Missing); thymus: 30.3483% (minimum 65%, Missing)",-0.346517,-0.287838,-0.482456,0,80,unavailable,16.7,8.7,14,"bone marrow: 16.7 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 8.7 nTPM (protected, limit 3); rectum: 6.3 nTPM (protected, limit 3); colon: 5 nTPM (protected, limit 3); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111247,RAD51AP1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.7544% (minimum 75%, Baseline (adaptation disabled)); colon: 54.9550% (minimum 70%, Baseline (adaptation disabled)); duodenum: 54.9550% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.3043% (minimum 70%, Baseline (adaptation disabled)); lymph node: 41.2162% (minimum 70%, Baseline (adaptation disabled)); rectum: 49.1935% (minimum 70%, Baseline (adaptation disabled)); small intestine: 56.4815% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.8936% (minimum 65%, Baseline (adaptation disabled)); thymus: 30.3483% (minimum 65%, Baseline (adaptation disabled))",-0.346517,-0.287838,-0.482456,0,80,unavailable,16.7,8.7,14,"bone marrow: 16.7 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 8.7 nTPM (protected, limit 3); rectum: 6.3 nTPM (protected, limit 3); colon: 5 nTPM (protected, limit 3); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111247,RAD51AP1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.9817% (minimum 99%, Missing); basal ganglia: 98.9817% (minimum 99%, Missing); hippocampal formation: 98.7805% (minimum 99%, Missing); midbrain: 98.3806% (minimum 99%, Missing); pituitary gland: 98.9817% (minimum 99%, Missing); spinal cord: 97.7867% (minimum 99%, Missing)",0.0418367,0.0248823,-0.0121328,0,3,partial,4.1,1.5,1.6,"spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111254,AKAP3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341837,0.294882,0.227867,0,3,partial,4.1,1.5,1.6,"spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111254,AKAP3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341837,0.294882,0.227867,0,3,partial,4.1,1.5,1.6,"spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111254,AKAP3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341837,0.294882,0.227867,0,3,partial,4.1,1.5,1.6,"spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111254,AKAP3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333806,0.284802,0.209526,0,3,partial,4.1,1.5,1.6,"heart muscle: 4.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111254,AKAP3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 97.3225% (minimum 99%, Missing); pancreas: 98.8647% (minimum 99%, Missing); retina: 93.4078% (minimum 99%, Missing)",0.0495218,0.0292828,-0.0559218,0,80,unavailable,29.5,0.3,0.2,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111305,GSG1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349522,0.299283,0.184078,0,80,unavailable,29.5,0.3,0.2,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111305,GSG1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349522,0.299283,0.184078,0,80,unavailable,29.5,0.3,0.2,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111305,GSG1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349522,0.299283,0.184078,0,80,unavailable,29.5,0.3,0.2,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111305,GSG1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349522,0.299283,0.184078,0,80,unavailable,29.5,0.3,0.2,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111305,GSG1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0392319,0.0285507,0.00386946,0,1,partial,10.5,5.4,13.4,"bone marrow: 10.5 nTPM (vital, limit 6); duodenum: 8.2 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6); retina: 1.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111644,ACRBP,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339232,0.298551,0.243869,0,1,partial,10.5,5.4,13.4,"bone marrow: 10.5 nTPM (vital, limit 6); duodenum: 8.2 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6); retina: 1.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111644,ACRBP,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339232,0.298551,0.243869,0,1,partial,10.5,5.4,13.4,"bone marrow: 10.5 nTPM (vital, limit 6); duodenum: 8.2 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6); retina: 1.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111644,ACRBP,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339232,0.298551,0.243869,0,1,partial,10.5,5.4,13.4,"bone marrow: 10.5 nTPM (vital, limit 6); duodenum: 8.2 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6); retina: 1.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111644,ACRBP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.303633,0.280783,0.2133,0,1,partial,10.5,5.4,13.4,"thyroid gland: 13.4 nTPM (manageable, limit 5); bone marrow: 10.5 nTPM (vital, limit 1); spleen: 8.9 nTPM (manageable, limit 5); duodenum: 8.2 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111644,ACRBP,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.5455% (minimum 95%, Missing); adrenal gland: 98.1132% (minimum 99%, Missing); amygdala: 96.2963% (minimum 99%, Missing); basal ganglia: 91.2281% (minimum 99%, Missing); bone marrow: 89.6552% (minimum 99%, Missing); cerebellum: 98.1132% (minimum 99%, Missing); cerebral cortex: 98.1132% (minimum 99%, Missing); choroid plexus: 42.9752% (minimum 99%, Missing); duodenum: 98.1132% (minimum 99%, Missing); heart muscle: 98.1132% (minimum 99%, Missing); hippocampal formation: 92.8571% (minimum 99%, Missing); hypothalamus: 91.2281% (minimum 99%, Missing); kidney: 96.2963% (minimum 99%, Missing); lung: 88.1356% (minimum 99%, Missing); midbrain: 98.1132% (minimum 99%, Missing); pancreas: 96.2963% (minimum 99%, Missing); parathyroid gland: 53.6082% (minimum 97%, Missing); pituitary gland: 86.6667% (minimum 99%, Missing); retina: 4.3154% (minimum 99%, Missing); salivary gland: 96.2963% (minimum 97%, Missing); skeletal muscle: 98.1132% (minimum 99%, Missing); small intestine: 98.1132% (minimum 99%, Missing); spinal cord: 98.1132% (minimum 99%, Missing); spleen: 88.1356% (minimum 95%, Missing); stomach: 94.5455% (minimum 97%, Missing)",-0.0686441,-0.433918,-0.946846,0,80,unavailable,115.3,4.5,0.7,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111837,MAK,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 42.9752% (minimum 75%, Missing); parathyroid gland: 53.6082% (minimum 70%, Missing); retina: 4.3154% (minimum 75%, Missing)",0.231356,-0.163918,-0.706846,0,80,unavailable,115.3,4.5,0.7,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111837,MAK,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 42.9752% (minimum 75%, Missing); parathyroid gland: 53.6082% (minimum 70%, Missing); retina: 4.3154% (minimum 75%, Missing)",0.231356,-0.163918,-0.706846,0,80,unavailable,115.3,4.5,0.7,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111837,MAK,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 42.9752% (minimum 75%, Missing); parathyroid gland: 53.6082% (minimum 70%, Missing); retina: 4.3154% (minimum 75%, Missing)",0.231356,-0.163918,-0.706846,0,80,unavailable,115.3,4.5,0.7,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111837,MAK,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 42.9752% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 53.6082% (minimum 70%, Baseline (adaptation disabled)); retina: 4.3154% (minimum 75%, Baseline (adaptation disabled))",0.231356,-0.163918,-0.706846,0,80,unavailable,115.3,4.5,0.7,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111837,MAK,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2560% (minimum 95%, Missing); adrenal gland: 55.8366% (minimum 99%, Missing); amygdala: 44.4961% (minimum 99%, Missing); basal ganglia: 48.2353% (minimum 99%, Missing); bone marrow: 70.5160% (minimum 98%, Approved); cerebellum: 55.0864% (minimum 99%, Missing); cerebral cortex: 47.5166% (minimum 99%, Missing); choroid plexus: 74.7396% (minimum 99%, Missing); colon: 60.1677% (minimum 97%, Missing); duodenum: 65.3759% (minimum 99%, Missing); esophagus: 57.1713% (minimum 97%, Missing); heart muscle: 51.2500% (minimum 99%, Missing); hippocampal formation: 44.2901% (minimum 99%, Missing); hypothalamus: 48.5618% (minimum 99%, Missing); kidney: 57.2854% (minimum 99%, Missing); liver: 51.1586% (minimum 99%, Missing); lung: 58.5714% (minimum 99%, Missing); lymph node: 72.4747% (minimum 97%, Missing); midbrain: 41.9591% (minimum 99%, Missing); pancreas: 60.6765% (minimum 99%, Missing); parathyroid gland: 49.2281% (minimum 97%, Missing); pituitary gland: 67.2131% (minimum 99%, Missing); rectum: 62.8009% (minimum 97%, Missing); retina: 66.4352% (minimum 99%, Missing); salivary gland: 53.6449% (minimum 97%, Missing); skeletal muscle: 20.9031% (minimum 99%, Missing); skin: 62.9386% (minimum 95%, Missing); small intestine: 64.9321% (minimum 99%, Missing); smooth muscle: 63.2159% (minimum 99%, Missing); spinal cord: 33.4109% (minimum 99%, Missing); spleen: 73.7789% (minimum 90%, Approved); stomach: 54.2533% (minimum 97%, Missing); thymus: 68.3333% (minimum 95%, Missing); thyroid gland: 55.8366% (minimum 95%, Missing); tongue: 26.1146% (minimum 97%, Missing); urinary bladder: 61.8534% (minimum 97%, Missing)",-0.391634,-0.708854,-0.780969,0,6,partial,108.6,81.2,22.7,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 2); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 2); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); salivary gland: 24.8 nTPM (protected, limit 2); stomach: 24.2 nTPM (protected, limit 2); cerebellum: 23.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 22.7 nTPM (vital, limit 1); esophagus: 21.5 nTPM (protected, limit 2); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 2); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 2); adipose tissue: 17.4 nTPM (manageable, limit 5); rectum: 17 nTPM (protected, limit 2); skin: 16.9 nTPM (manageable, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); bone marrow: 12 nTPM (vital, limit 2); lymph node: 10.9 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 10); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111911,HINT3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2560% (minimum 65%, Missing); adrenal gland: 55.8366% (minimum 75%, Missing); amygdala: 44.4961% (minimum 75%, Missing); basal ganglia: 48.2353% (minimum 75%, Missing); cerebellum: 55.0864% (minimum 75%, Missing); cerebral cortex: 47.5166% (minimum 75%, Missing); choroid plexus: 74.7396% (minimum 75%, Missing); colon: 60.1677% (minimum 70%, Missing); duodenum: 65.3759% (minimum 75%, Missing); esophagus: 57.1713% (minimum 70%, Missing); heart muscle: 51.2500% (minimum 75%, Missing); hippocampal formation: 44.2901% (minimum 75%, Missing); hypothalamus: 48.5618% (minimum 75%, Missing); kidney: 57.2854% (minimum 75%, Missing); liver: 51.1586% (minimum 75%, Missing); lung: 58.5714% (minimum 75%, Missing); midbrain: 41.9591% (minimum 75%, Missing); pancreas: 60.6765% (minimum 75%, Missing); parathyroid gland: 49.2281% (minimum 70%, Missing); pituitary gland: 67.2131% (minimum 75%, Missing); rectum: 62.8009% (minimum 70%, Missing); retina: 66.4352% (minimum 75%, Missing); salivary gland: 53.6449% (minimum 70%, Missing); skeletal muscle: 20.9031% (minimum 75%, Missing); skin: 62.9386% (minimum 65%, Missing); small intestine: 64.9321% (minimum 75%, Missing); smooth muscle: 63.2159% (minimum 75%, Missing); spinal cord: 33.4109% (minimum 75%, Missing); stomach: 54.2533% (minimum 70%, Missing); thyroid gland: 55.8366% (minimum 65%, Missing); tongue: 26.1146% (minimum 70%, Missing); urinary bladder: 61.8534% (minimum 70%, Missing)",-0.0916342,-0.438854,-0.540969,0,6,partial,108.6,81.2,22.7,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 2); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 2); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); salivary gland: 24.8 nTPM (protected, limit 2); stomach: 24.2 nTPM (protected, limit 2); cerebellum: 23.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 22.7 nTPM (vital, limit 1); esophagus: 21.5 nTPM (protected, limit 2); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 2); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 2); adipose tissue: 17.4 nTPM (manageable, limit 5); rectum: 17 nTPM (protected, limit 2); skin: 16.9 nTPM (manageable, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); bone marrow: 12 nTPM (vital, limit 2); lymph node: 10.9 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 10); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111911,HINT3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2560% (minimum 65%, Missing); adrenal gland: 55.8366% (minimum 75%, Missing); amygdala: 44.4961% (minimum 75%, Missing); basal ganglia: 48.2353% (minimum 75%, Missing); cerebellum: 55.0864% (minimum 75%, Missing); cerebral cortex: 47.5166% (minimum 75%, Missing); choroid plexus: 74.7396% (minimum 75%, Missing); colon: 60.1677% (minimum 70%, Missing); duodenum: 65.3759% (minimum 75%, Missing); esophagus: 57.1713% (minimum 70%, Missing); heart muscle: 51.2500% (minimum 75%, Missing); hippocampal formation: 44.2901% (minimum 75%, Missing); hypothalamus: 48.5618% (minimum 75%, Missing); kidney: 57.2854% (minimum 75%, Missing); liver: 51.1586% (minimum 75%, Missing); lung: 58.5714% (minimum 75%, Missing); midbrain: 41.9591% (minimum 75%, Missing); pancreas: 60.6765% (minimum 75%, Missing); parathyroid gland: 49.2281% (minimum 70%, Missing); pituitary gland: 67.2131% (minimum 75%, Missing); rectum: 62.8009% (minimum 70%, Missing); retina: 66.4352% (minimum 75%, Missing); salivary gland: 53.6449% (minimum 70%, Missing); skeletal muscle: 20.9031% (minimum 75%, Missing); skin: 62.9386% (minimum 65%, Missing); small intestine: 64.9321% (minimum 75%, Missing); smooth muscle: 63.2159% (minimum 75%, Missing); spinal cord: 33.4109% (minimum 75%, Missing); stomach: 54.2533% (minimum 70%, Missing); thyroid gland: 55.8366% (minimum 65%, Missing); tongue: 26.1146% (minimum 70%, Missing); urinary bladder: 61.8534% (minimum 70%, Missing)",-0.0916342,-0.438854,-0.540969,0,6,partial,108.6,81.2,22.7,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 3); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 3); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); salivary gland: 24.8 nTPM (protected, limit 3); stomach: 24.2 nTPM (protected, limit 3); cerebellum: 23.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 22.7 nTPM (vital, limit 1); esophagus: 21.5 nTPM (protected, limit 3); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 3); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 3); adipose tissue: 17.4 nTPM (manageable, limit 5); rectum: 17 nTPM (protected, limit 3); skin: 16.9 nTPM (manageable, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); bone marrow: 12 nTPM (vital, limit 2); lymph node: 10.9 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 10); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111911,HINT3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2560% (minimum 65%, Missing); adrenal gland: 55.8366% (minimum 75%, Missing); amygdala: 44.4961% (minimum 75%, Missing); basal ganglia: 48.2353% (minimum 75%, Missing); cerebellum: 55.0864% (minimum 75%, Missing); cerebral cortex: 47.5166% (minimum 75%, Missing); choroid plexus: 74.7396% (minimum 75%, Missing); colon: 60.1677% (minimum 70%, Missing); duodenum: 65.3759% (minimum 75%, Missing); esophagus: 57.1713% (minimum 70%, Missing); heart muscle: 51.2500% (minimum 75%, Missing); hippocampal formation: 44.2901% (minimum 75%, Missing); hypothalamus: 48.5618% (minimum 75%, Missing); kidney: 57.2854% (minimum 75%, Missing); liver: 51.1586% (minimum 75%, Missing); lung: 58.5714% (minimum 75%, Missing); midbrain: 41.9591% (minimum 75%, Missing); pancreas: 60.6765% (minimum 75%, Missing); parathyroid gland: 49.2281% (minimum 70%, Missing); pituitary gland: 67.2131% (minimum 75%, Missing); rectum: 62.8009% (minimum 70%, Missing); retina: 66.4352% (minimum 75%, Missing); salivary gland: 53.6449% (minimum 70%, Missing); skeletal muscle: 20.9031% (minimum 75%, Missing); skin: 62.9386% (minimum 65%, Missing); small intestine: 64.9321% (minimum 75%, Missing); smooth muscle: 63.2159% (minimum 75%, Missing); spinal cord: 33.4109% (minimum 75%, Missing); stomach: 54.2533% (minimum 70%, Missing); thyroid gland: 55.8366% (minimum 65%, Missing); tongue: 26.1146% (minimum 70%, Missing); urinary bladder: 61.8534% (minimum 70%, Missing)",-0.0916342,-0.438854,-0.540969,0,6,partial,108.6,81.2,22.7,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 3); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 3); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); salivary gland: 24.8 nTPM (protected, limit 3); stomach: 24.2 nTPM (protected, limit 3); cerebellum: 23.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 22.7 nTPM (vital, limit 1); esophagus: 21.5 nTPM (protected, limit 3); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 3); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 3); adipose tissue: 17.4 nTPM (manageable, limit 5); rectum: 17 nTPM (protected, limit 3); skin: 16.9 nTPM (manageable, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); bone marrow: 12 nTPM (vital, limit 2); lymph node: 10.9 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 10); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111911,HINT3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2560% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 55.8366% (minimum 75%, Baseline (adaptation disabled)); amygdala: 44.4961% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 48.2353% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 70.5160% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.0864% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 47.5166% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.7396% (minimum 75%, Baseline (adaptation disabled)); colon: 60.1677% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.3759% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.1713% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 51.2500% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 44.2901% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 48.5618% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.2854% (minimum 75%, Baseline (adaptation disabled)); liver: 51.1586% (minimum 75%, Baseline (adaptation disabled)); lung: 58.5714% (minimum 75%, Baseline (adaptation disabled)); midbrain: 41.9591% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.6765% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.2281% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.2131% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.8009% (minimum 70%, Baseline (adaptation disabled)); retina: 66.4352% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.6449% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 20.9031% (minimum 75%, Baseline (adaptation disabled)); skin: 62.9386% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.9321% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.2159% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 33.4109% (minimum 75%, Baseline (adaptation disabled)); stomach: 54.2533% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 55.8366% (minimum 65%, Baseline (adaptation disabled)); tongue: 26.1146% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.8534% (minimum 70%, Baseline (adaptation disabled))",-0.0916342,-0.438854,-0.540969,0,6,partial,108.6,81.2,22.7,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 3); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 3); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); salivary gland: 24.8 nTPM (protected, limit 3); stomach: 24.2 nTPM (protected, limit 3); cerebellum: 23.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 22.7 nTPM (vital, limit 1); esophagus: 21.5 nTPM (protected, limit 3); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 3); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 3); adipose tissue: 17.4 nTPM (manageable, limit 5); rectum: 17 nTPM (protected, limit 3); skin: 16.9 nTPM (manageable, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); bone marrow: 12 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 5); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000111911,HINT3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.0330% (minimum 95%, Missing); adrenal gland: 67.0330% (minimum 99%, Missing); amygdala: 79.2208% (minimum 99%, Missing); basal ganglia: 80.2632% (minimum 99%, Missing); bone marrow: 12.2984% (minimum 99%, Missing); cerebellum: 63.5417% (minimum 99%, Missing); cerebral cortex: 70.9302% (minimum 99%, Missing); choroid plexus: 76.2500% (minimum 99%, Missing); colon: 55.9633% (minimum 97%, Missing); duodenum: 57.5472% (minimum 99%, Missing); esophagus: 62.8866% (minimum 97%, Missing); heart muscle: 78.2051% (minimum 99%, Missing); hippocampal formation: 80.2632% (minimum 99%, Missing); hypothalamus: 81.3333% (minimum 99%, Missing); kidney: 67.0330% (minimum 99%, Missing); liver: 58.6538% (minimum 99%, Missing); lung: 64.8936% (minimum 99%, Missing); lymph node: 29.6117% (minimum 97%, Missing); midbrain: 80.2632% (minimum 99%, Missing); pancreas: 67.7778% (minimum 99%, Missing); parathyroid gland: 73.4940% (minimum 97%, Missing); pituitary gland: 75.3086% (minimum 99%, Missing); rectum: 54.9550% (minimum 97%, Missing); retina: 65.5914% (minimum 99%, Missing); salivary gland: 70.1149% (minimum 97%, Missing); skeletal muscle: 87.1429% (minimum 99%, Missing); skin: 59.2233% (minimum 95%, Missing); small intestine: 59.2233% (minimum 99%, Missing); smooth muscle: 55.9633% (minimum 99%, Missing); spinal cord: 79.2208% (minimum 99%, Missing); spleen: 53.0435% (minimum 95%, Missing); stomach: 57.5472% (minimum 97%, Missing); thymus: 18.6544% (minimum 95%, Missing); thyroid gland: 59.2233% (minimum 95%, Missing); tongue: 70.9302% (minimum 97%, Missing); urinary bladder: 61.6162% (minimum 97%, Missing)",-0.763456,-0.673883,-0.867016,0,2,partial,43.5,14.5,26.6,"bone marrow: 43.5 nTPM (vital, limit 1); thymus: 26.6 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); stomach: 4.5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112029,FBXO5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.0330% (minimum 75%, Missing); bone marrow: 12.2984% (minimum 75%, Missing); cerebellum: 63.5417% (minimum 75%, Missing); cerebral cortex: 70.9302% (minimum 75%, Missing); colon: 55.9633% (minimum 70%, Missing); duodenum: 57.5472% (minimum 75%, Missing); esophagus: 62.8866% (minimum 70%, Missing); kidney: 67.0330% (minimum 75%, Missing); liver: 58.6538% (minimum 75%, Missing); lung: 64.8936% (minimum 75%, Missing); lymph node: 29.6117% (minimum 70%, Missing); pancreas: 67.7778% (minimum 75%, Missing); rectum: 54.9550% (minimum 70%, Missing); retina: 65.5914% (minimum 75%, Missing); skin: 59.2233% (minimum 65%, Missing); small intestine: 59.2233% (minimum 75%, Missing); smooth muscle: 55.9633% (minimum 75%, Missing); spleen: 53.0435% (minimum 65%, Missing); stomach: 57.5472% (minimum 70%, Missing); thymus: 18.6544% (minimum 65%, Missing); thyroid gland: 59.2233% (minimum 65%, Missing); urinary bladder: 61.6162% (minimum 70%, Missing)",-0.463456,-0.403883,-0.627016,0,2,partial,43.5,14.5,26.6,"bone marrow: 43.5 nTPM (vital, limit 1); thymus: 26.6 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); stomach: 4.5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112029,FBXO5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.0330% (minimum 75%, Missing); bone marrow: 12.2984% (minimum 75%, Missing); cerebellum: 63.5417% (minimum 75%, Missing); cerebral cortex: 70.9302% (minimum 75%, Missing); colon: 55.9633% (minimum 70%, Missing); duodenum: 57.5472% (minimum 75%, Missing); esophagus: 62.8866% (minimum 70%, Missing); kidney: 67.0330% (minimum 75%, Missing); liver: 58.6538% (minimum 75%, Missing); lung: 64.8936% (minimum 75%, Missing); lymph node: 29.6117% (minimum 70%, Missing); pancreas: 67.7778% (minimum 75%, Missing); rectum: 54.9550% (minimum 70%, Missing); retina: 65.5914% (minimum 75%, Missing); skin: 59.2233% (minimum 65%, Missing); small intestine: 59.2233% (minimum 75%, Missing); smooth muscle: 55.9633% (minimum 75%, Missing); spleen: 53.0435% (minimum 65%, Missing); stomach: 57.5472% (minimum 70%, Missing); thymus: 18.6544% (minimum 65%, Missing); thyroid gland: 59.2233% (minimum 65%, Missing); urinary bladder: 61.6162% (minimum 70%, Missing)",-0.463456,-0.403883,-0.627016,0,2,partial,43.5,14.5,26.6,"bone marrow: 43.5 nTPM (vital, limit 1); thymus: 26.6 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); stomach: 4.5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112029,FBXO5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.0330% (minimum 75%, Missing); bone marrow: 12.2984% (minimum 75%, Missing); cerebellum: 63.5417% (minimum 75%, Missing); cerebral cortex: 70.9302% (minimum 75%, Missing); colon: 55.9633% (minimum 70%, Missing); duodenum: 57.5472% (minimum 75%, Missing); esophagus: 62.8866% (minimum 70%, Missing); kidney: 67.0330% (minimum 75%, Missing); liver: 58.6538% (minimum 75%, Missing); lung: 64.8936% (minimum 75%, Missing); lymph node: 29.6117% (minimum 70%, Missing); pancreas: 67.7778% (minimum 75%, Missing); rectum: 54.9550% (minimum 70%, Missing); retina: 65.5914% (minimum 75%, Missing); skin: 59.2233% (minimum 65%, Missing); small intestine: 59.2233% (minimum 75%, Missing); smooth muscle: 55.9633% (minimum 75%, Missing); spleen: 53.0435% (minimum 65%, Missing); stomach: 57.5472% (minimum 70%, Missing); thymus: 18.6544% (minimum 65%, Missing); thyroid gland: 59.2233% (minimum 65%, Missing); urinary bladder: 61.6162% (minimum 70%, Missing)",-0.463456,-0.403883,-0.627016,0,2,partial,43.5,14.5,26.6,"bone marrow: 43.5 nTPM (vital, limit 1); thymus: 26.6 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); stomach: 4.5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112029,FBXO5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.0330% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 12.2984% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 63.5417% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.9302% (minimum 75%, Baseline (adaptation disabled)); colon: 55.9633% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.5472% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.8866% (minimum 70%, Baseline (adaptation disabled)); kidney: 67.0330% (minimum 75%, Baseline (adaptation disabled)); liver: 58.6538% (minimum 75%, Baseline (adaptation disabled)); lung: 64.8936% (minimum 75%, Baseline (adaptation disabled)); lymph node: 29.6117% (minimum 70%, Baseline (adaptation disabled)); pancreas: 67.7778% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.9550% (minimum 70%, Baseline (adaptation disabled)); retina: 65.5914% (minimum 75%, Baseline (adaptation disabled)); skin: 59.2233% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.2233% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.9633% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.0435% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.5472% (minimum 70%, Baseline (adaptation disabled)); thymus: 18.6544% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 59.2233% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 61.6162% (minimum 70%, Baseline (adaptation disabled))",-0.463456,-0.403883,-0.627016,0,2,partial,43.5,14.5,26.6,"bone marrow: 43.5 nTPM (vital, limit 1); thymus: 26.6 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); stomach: 4.5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112029,FBXO5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 77.7778% (minimum 95%, Enhanced); amygdala: 96.5517% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 80.0000% (minimum 95%, Enhanced); cerebellum: 57.1429% (minimum 95%, Enhanced); cerebral cortex: 82.3529% (minimum 95%, Enhanced); choroid plexus: 90.3226% (minimum 99%, Missing); duodenum: 93.3333% (minimum 95%, Enhanced); esophagus: 73.6842% (minimum 80%, Enhanced); hypothalamus: 87.5000% (minimum 99%, Missing); kidney: 93.3333% (minimum 95%, Enhanced); liver: 93.3333% (minimum 95%, Enhanced); lung: 93.3333% (minimum 95%, Enhanced); pancreas: 93.3333% (minimum 95%, Enhanced); retina: 75.6757% (minimum 99%, Missing); skeletal muscle: 90.3226% (minimum 95%, Enhanced); small intestine: 93.3333% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 95%, Enhanced); thymus: 93.3333% (minimum 95%, Missing); tongue: 96.5517% (minimum 97%, Missing)",-0.0166667,-0.0631579,-0.378571,0,3,partial,2.1,1,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112038,OPRM1,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 57.1429% (minimum 60%, Enhanced)",0.283333,0.186842,-0.0285714,0,3,partial,2.1,1,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112038,OPRM1,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 57.1429% (minimum 60%, Enhanced)",0.283333,0.186842,-0.0285714,0,3,partial,2.1,1,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112038,OPRM1,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 57.1429% (minimum 60%, Enhanced)",0.283333,0.186842,-0.0285714,0,3,partial,2.1,1,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112038,OPRM1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 57.1429% (minimum 75%, Baseline (adaptation disabled))",0.173529,0.0368421,-0.178571,0,3,partial,2.1,1,0.6,"cerebellum: 2.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112038,OPRM1,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8453% (minimum 99%, Missing); basal ganglia: 96.1798% (minimum 99%, Missing); bone marrow: 89.7275% (minimum 95%, Enhanced); cerebellum: 91.4530% (minimum 95%, Enhanced); hypothalamus: 96.1798% (minimum 99%, Missing); midbrain: 98.8453% (minimum 99%, Missing)",0.05,0.027669,-0.0527254,0,2,partial,4.9,0.1,1,"basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112053,SLC26A8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.297669,0.211798,0,2,partial,4.9,0.1,1,"basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112053,SLC26A8,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.297669,0.211798,0,2,partial,4.9,0.1,1,"basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112053,SLC26A8,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.297669,0.211798,0,2,partial,4.9,0.1,1,"basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112053,SLC26A8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.327169,0.297669,0.147275,0,2,partial,4.9,0.1,1,"bone marrow: 4.9 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112053,SLC26A8,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112116,IL17F,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112116,IL17F,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112116,IL17F,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112116,IL17F,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112116,IL17F,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 67.5000% (minimum 95%, Missing); adrenal gland: 79.4118% (minimum 99%, Missing); amygdala: 93.1034% (minimum 99%, Missing); basal ganglia: 93.1034% (minimum 99%, Missing); bone marrow: 27.2727% (minimum 99%, Missing); cerebellum: 84.3750% (minimum 99%, Missing); cerebral cortex: 58.6957% (minimum 99%, Missing); choroid plexus: 93.1034% (minimum 99%, Missing); colon: 84.3750% (minimum 97%, Missing); duodenum: 90.0000% (minimum 99%, Missing); heart muscle: 71.0526% (minimum 99%, Missing); hippocampal formation: 93.1034% (minimum 99%, Missing); hypothalamus: 96.4286% (minimum 99%, Missing); kidney: 87.0968% (minimum 99%, Missing); liver: 69.2308% (minimum 95%, Enhanced); lung: 75.0000% (minimum 99%, Missing); lymph node: 13.6364% (minimum 97%, Missing); midbrain: 96.4286% (minimum 99%, Missing); pancreas: 71.0526% (minimum 95%, Enhanced); parathyroid gland: 62.7907% (minimum 97%, Missing); pituitary gland: 96.4286% (minimum 99%, Missing); rectum: 84.3750% (minimum 97%, Missing); retina: 67.5000% (minimum 99%, Missing); salivary gland: 71.0526% (minimum 97%, Missing); skeletal muscle: 57.4468% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 69.2308% (minimum 99%, Missing); smooth muscle: 71.0526% (minimum 99%, Missing); spinal cord: 93.1034% (minimum 99%, Missing); spleen: 36.4865% (minimum 60%, Enhanced); stomach: 81.8182% (minimum 97%, Missing); thymus: 17.5325% (minimum 95%, Missing); thyroid gland: 87.0968% (minimum 95%, Missing); tongue: 54.0000% (minimum 97%, Missing); urinary bladder: 67.5000% (minimum 97%, Missing)",-0.774675,-0.833636,-0.717273,0,5,partial,7.2,17.1,12.7,"lymph node: 17.1 nTPM (protected, limit 2); thymus: 12.7 nTPM (manageable, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112182,BACH2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 27.2727% (minimum 75%, Missing); cerebral cortex: 58.6957% (minimum 75%, Missing); heart muscle: 71.0526% (minimum 75%, Missing); lymph node: 13.6364% (minimum 70%, Missing); parathyroid gland: 62.7907% (minimum 70%, Missing); retina: 67.5000% (minimum 75%, Missing); skeletal muscle: 57.4468% (minimum 75%, Missing); small intestine: 69.2308% (minimum 75%, Missing); smooth muscle: 71.0526% (minimum 75%, Missing); spleen: 36.4865% (minimum 50%, Enhanced); thymus: 17.5325% (minimum 65%, Missing); tongue: 54.0000% (minimum 70%, Missing); urinary bladder: 67.5000% (minimum 70%, Missing)",-0.474675,-0.563636,-0.477273,0,5,partial,7.2,17.1,12.7,"lymph node: 17.1 nTPM (protected, limit 2); thymus: 12.7 nTPM (manageable, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112182,BACH2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 27.2727% (minimum 75%, Missing); cerebral cortex: 58.6957% (minimum 75%, Missing); heart muscle: 71.0526% (minimum 75%, Missing); lymph node: 13.6364% (minimum 70%, Missing); parathyroid gland: 62.7907% (minimum 70%, Missing); retina: 67.5000% (minimum 75%, Missing); skeletal muscle: 57.4468% (minimum 75%, Missing); small intestine: 69.2308% (minimum 75%, Missing); smooth muscle: 71.0526% (minimum 75%, Missing); spleen: 36.4865% (minimum 50%, Enhanced); thymus: 17.5325% (minimum 65%, Missing); tongue: 54.0000% (minimum 70%, Missing); urinary bladder: 67.5000% (minimum 70%, Missing)",-0.474675,-0.563636,-0.477273,0,5,partial,7.2,17.1,12.7,"lymph node: 17.1 nTPM (protected, limit 3); thymus: 12.7 nTPM (manageable, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112182,BACH2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 27.2727% (minimum 75%, Missing); cerebral cortex: 58.6957% (minimum 75%, Missing); heart muscle: 71.0526% (minimum 75%, Missing); lymph node: 13.6364% (minimum 70%, Missing); parathyroid gland: 62.7907% (minimum 70%, Missing); retina: 67.5000% (minimum 75%, Missing); skeletal muscle: 57.4468% (minimum 75%, Missing); small intestine: 69.2308% (minimum 75%, Missing); smooth muscle: 71.0526% (minimum 75%, Missing); spleen: 36.4865% (minimum 50%, Enhanced); thymus: 17.5325% (minimum 65%, Missing); tongue: 54.0000% (minimum 70%, Missing); urinary bladder: 67.5000% (minimum 70%, Missing)",-0.474675,-0.563636,-0.477273,0,5,partial,7.2,17.1,12.7,"lymph node: 17.1 nTPM (protected, limit 3); thymus: 12.7 nTPM (manageable, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112182,BACH2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 27.2727% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.6957% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.0526% (minimum 75%, Baseline (adaptation disabled)); liver: 69.2308% (minimum 75%, Baseline (adaptation disabled)); lymph node: 13.6364% (minimum 70%, Baseline (adaptation disabled)); pancreas: 71.0526% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.7907% (minimum 70%, Baseline (adaptation disabled)); retina: 67.5000% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 57.4468% (minimum 75%, Baseline (adaptation disabled)); small intestine: 69.2308% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.0526% (minimum 75%, Baseline (adaptation disabled)); spleen: 36.4865% (minimum 65%, Baseline (adaptation disabled)); thymus: 17.5325% (minimum 65%, Baseline (adaptation disabled)); tongue: 54.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.5000% (minimum 70%, Baseline (adaptation disabled))",-0.474675,-0.563636,-0.477273,0,5,partial,7.2,17.1,12.7,"lymph node: 17.1 nTPM (protected, limit 3); thymus: 12.7 nTPM (manageable, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112182,BACH2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112238,PRDM13,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112238,PRDM13,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112238,PRDM13,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112238,PRDM13,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112238,PRDM13,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 95%, Missing); hypothalamus: 77.7778% (minimum 99%, Missing); kidney: 22.7642% (minimum 99%, Missing); liver: 90.3226% (minimum 99%, Missing); pancreas: 60.8696% (minimum 99%, Missing); skeletal muscle: 45.1613% (minimum 99%, Missing); skin: 90.3226% (minimum 95%, Missing); tongue: 90.3226% (minimum 97%, Missing)",-0.313636,-0.0667742,-0.762358,0,80,unavailable,9.5,0.3,1.6,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112246,SIM1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); kidney: 22.7642% (minimum 75%, Missing); pancreas: 60.8696% (minimum 75%, Missing); skeletal muscle: 45.1613% (minimum 75%, Missing)",-0.0136364,0.203226,-0.522358,0,80,unavailable,9.5,0.3,1.6,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112246,SIM1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); kidney: 22.7642% (minimum 75%, Missing); pancreas: 60.8696% (minimum 75%, Missing); skeletal muscle: 45.1613% (minimum 75%, Missing)",-0.0136364,0.203226,-0.522358,0,80,unavailable,9.5,0.3,1.6,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112246,SIM1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); kidney: 22.7642% (minimum 75%, Missing); pancreas: 60.8696% (minimum 75%, Missing); skeletal muscle: 45.1613% (minimum 75%, Missing)",-0.0136364,0.203226,-0.522358,0,80,unavailable,9.5,0.3,1.6,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112246,SIM1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Baseline (adaptation disabled)); kidney: 22.7642% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.8696% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 45.1613% (minimum 75%, Baseline (adaptation disabled))",-0.0136364,0.203226,-0.522358,0,80,unavailable,9.5,0.3,1.6,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112246,SIM1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.00550056,0,2,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112273,HDGFL1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245501,0,2,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112273,HDGFL1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245501,0,2,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112273,HDGFL1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245501,0,2,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112273,HDGFL1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245501,0,2,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112273,HDGFL1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 65.0943% (minimum 95%, Missing); adrenal gland: 57.5000% (minimum 99%, Missing); amygdala: 85.1852% (minimum 99%, Missing); basal ganglia: 81.6568% (minimum 99%, Missing); bone marrow: 38.8732% (minimum 99%, Missing); cerebellum: 54.1176% (minimum 99%, Missing); cerebral cortex: 66.0287% (minimum 99%, Missing); choroid plexus: 79.7688% (minimum 99%, Missing); colon: 57.5000% (minimum 97%, Missing); duodenum: 55.4217% (minimum 99%, Missing); esophagus: 62.7273% (minimum 97%, Missing); heart muscle: 68.6567% (minimum 99%, Missing); hippocampal formation: 83.6364% (minimum 99%, Missing); hypothalamus: 82.1429% (minimum 99%, Missing); kidney: 57.9832% (minimum 99%, Missing); liver: 64.4860% (minimum 99%, Missing); lung: 58.9744% (minimum 99%, Missing); lymph node: 48.7633% (minimum 97%, Missing); midbrain: 85.1852% (minimum 99%, Missing); pancreas: 57.2614% (minimum 99%, Missing); parathyroid gland: 43.8095% (minimum 97%, Missing); pituitary gland: 70.0508% (minimum 99%, Missing); rectum: 53.2819% (minimum 97%, Missing); retina: 55.4217% (minimum 99%, Missing); salivary gland: 52.6718% (minimum 97%, Missing); skeletal muscle: 65.7143% (minimum 99%, Missing); skin: 55.2000% (minimum 95%, Missing); small intestine: 57.2614% (minimum 99%, Missing); smooth muscle: 57.9832% (minimum 99%, Missing); spinal cord: 81.1765% (minimum 99%, Missing); spleen: 52.4715% (minimum 95%, Missing); stomach: 54.9801% (minimum 97%, Missing); thymus: 44.0895% (minimum 95%, Missing); thyroid gland: 49.6403% (minimum 95%, Missing); tongue: 58.7234% (minimum 97%, Missing); urinary bladder: 58.4746% (minimum 97%, Missing)",-0.509105,-0.531905,-0.601268,0,80,unavailable,21.7,17.7,17.5,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 2); thymus: 17.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); thyroid gland: 14 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); salivary gland: 12.4 nTPM (protected, limit 2); rectum: 12.1 nTPM (protected, limit 2); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 2); skin: 11.2 nTPM (manageable, limit 5); retina: 11.1 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 2); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 2); tongue: 9.7 nTPM (protected, limit 2); lung: 9.6 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 2); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112282,MED23,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.5000% (minimum 75%, Missing); bone marrow: 38.8732% (minimum 75%, Missing); cerebellum: 54.1176% (minimum 75%, Missing); cerebral cortex: 66.0287% (minimum 75%, Missing); colon: 57.5000% (minimum 70%, Missing); duodenum: 55.4217% (minimum 75%, Missing); esophagus: 62.7273% (minimum 70%, Missing); heart muscle: 68.6567% (minimum 75%, Missing); kidney: 57.9832% (minimum 75%, Missing); liver: 64.4860% (minimum 75%, Missing); lung: 58.9744% (minimum 75%, Missing); lymph node: 48.7633% (minimum 70%, Missing); pancreas: 57.2614% (minimum 75%, Missing); parathyroid gland: 43.8095% (minimum 70%, Missing); pituitary gland: 70.0508% (minimum 75%, Missing); rectum: 53.2819% (minimum 70%, Missing); retina: 55.4217% (minimum 75%, Missing); salivary gland: 52.6718% (minimum 70%, Missing); skeletal muscle: 65.7143% (minimum 75%, Missing); skin: 55.2000% (minimum 65%, Missing); small intestine: 57.2614% (minimum 75%, Missing); smooth muscle: 57.9832% (minimum 75%, Missing); spleen: 52.4715% (minimum 65%, Missing); stomach: 54.9801% (minimum 70%, Missing); thymus: 44.0895% (minimum 65%, Missing); thyroid gland: 49.6403% (minimum 65%, Missing); tongue: 58.7234% (minimum 70%, Missing); urinary bladder: 58.4746% (minimum 70%, Missing)",-0.209105,-0.261905,-0.361268,0,80,unavailable,21.7,17.7,17.5,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 2); thymus: 17.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); thyroid gland: 14 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); salivary gland: 12.4 nTPM (protected, limit 2); rectum: 12.1 nTPM (protected, limit 2); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 2); skin: 11.2 nTPM (manageable, limit 5); retina: 11.1 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 2); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 2); tongue: 9.7 nTPM (protected, limit 2); lung: 9.6 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 2); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112282,MED23,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.5000% (minimum 75%, Missing); bone marrow: 38.8732% (minimum 75%, Missing); cerebellum: 54.1176% (minimum 75%, Missing); cerebral cortex: 66.0287% (minimum 75%, Missing); colon: 57.5000% (minimum 70%, Missing); duodenum: 55.4217% (minimum 75%, Missing); esophagus: 62.7273% (minimum 70%, Missing); heart muscle: 68.6567% (minimum 75%, Missing); kidney: 57.9832% (minimum 75%, Missing); liver: 64.4860% (minimum 75%, Missing); lung: 58.9744% (minimum 75%, Missing); lymph node: 48.7633% (minimum 70%, Missing); pancreas: 57.2614% (minimum 75%, Missing); parathyroid gland: 43.8095% (minimum 70%, Missing); pituitary gland: 70.0508% (minimum 75%, Missing); rectum: 53.2819% (minimum 70%, Missing); retina: 55.4217% (minimum 75%, Missing); salivary gland: 52.6718% (minimum 70%, Missing); skeletal muscle: 65.7143% (minimum 75%, Missing); skin: 55.2000% (minimum 65%, Missing); small intestine: 57.2614% (minimum 75%, Missing); smooth muscle: 57.9832% (minimum 75%, Missing); spleen: 52.4715% (minimum 65%, Missing); stomach: 54.9801% (minimum 70%, Missing); thymus: 44.0895% (minimum 65%, Missing); thyroid gland: 49.6403% (minimum 65%, Missing); tongue: 58.7234% (minimum 70%, Missing); urinary bladder: 58.4746% (minimum 70%, Missing)",-0.209105,-0.261905,-0.361268,0,80,unavailable,21.7,17.7,17.5,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 3); thymus: 17.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); thyroid gland: 14 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); salivary gland: 12.4 nTPM (protected, limit 3); rectum: 12.1 nTPM (protected, limit 3); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 3); skin: 11.2 nTPM (manageable, limit 5); retina: 11.1 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 3); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 3); tongue: 9.7 nTPM (protected, limit 3); lung: 9.6 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 3); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112282,MED23,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.5000% (minimum 75%, Missing); bone marrow: 38.8732% (minimum 75%, Missing); cerebellum: 54.1176% (minimum 75%, Missing); cerebral cortex: 66.0287% (minimum 75%, Missing); colon: 57.5000% (minimum 70%, Missing); duodenum: 55.4217% (minimum 75%, Missing); esophagus: 62.7273% (minimum 70%, Missing); heart muscle: 68.6567% (minimum 75%, Missing); kidney: 57.9832% (minimum 75%, Missing); liver: 64.4860% (minimum 75%, Missing); lung: 58.9744% (minimum 75%, Missing); lymph node: 48.7633% (minimum 70%, Missing); pancreas: 57.2614% (minimum 75%, Missing); parathyroid gland: 43.8095% (minimum 70%, Missing); pituitary gland: 70.0508% (minimum 75%, Missing); rectum: 53.2819% (minimum 70%, Missing); retina: 55.4217% (minimum 75%, Missing); salivary gland: 52.6718% (minimum 70%, Missing); skeletal muscle: 65.7143% (minimum 75%, Missing); skin: 55.2000% (minimum 65%, Missing); small intestine: 57.2614% (minimum 75%, Missing); smooth muscle: 57.9832% (minimum 75%, Missing); spleen: 52.4715% (minimum 65%, Missing); stomach: 54.9801% (minimum 70%, Missing); thymus: 44.0895% (minimum 65%, Missing); thyroid gland: 49.6403% (minimum 65%, Missing); tongue: 58.7234% (minimum 70%, Missing); urinary bladder: 58.4746% (minimum 70%, Missing)",-0.209105,-0.261905,-0.361268,0,80,unavailable,21.7,17.7,17.5,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 3); thymus: 17.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); thyroid gland: 14 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); salivary gland: 12.4 nTPM (protected, limit 3); rectum: 12.1 nTPM (protected, limit 3); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 3); skin: 11.2 nTPM (manageable, limit 5); retina: 11.1 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 3); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 3); tongue: 9.7 nTPM (protected, limit 3); lung: 9.6 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 3); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112282,MED23,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.5000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 38.8732% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.1176% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.0287% (minimum 75%, Baseline (adaptation disabled)); colon: 57.5000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 55.4217% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.7273% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.6567% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.9832% (minimum 75%, Baseline (adaptation disabled)); liver: 64.4860% (minimum 75%, Baseline (adaptation disabled)); lung: 58.9744% (minimum 75%, Baseline (adaptation disabled)); lymph node: 48.7633% (minimum 70%, Baseline (adaptation disabled)); pancreas: 57.2614% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 43.8095% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.0508% (minimum 75%, Baseline (adaptation disabled)); rectum: 53.2819% (minimum 70%, Baseline (adaptation disabled)); retina: 55.4217% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 52.6718% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 65.7143% (minimum 75%, Baseline (adaptation disabled)); skin: 55.2000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.2614% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.9832% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.4715% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.9801% (minimum 70%, Baseline (adaptation disabled)); thymus: 44.0895% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 49.6403% (minimum 65%, Baseline (adaptation disabled)); tongue: 58.7234% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.4746% (minimum 70%, Baseline (adaptation disabled))",-0.209105,-0.261905,-0.361268,0,80,unavailable,21.7,17.7,17.5,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 3); thymus: 17.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); thyroid gland: 14 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); salivary gland: 12.4 nTPM (protected, limit 3); rectum: 12.1 nTPM (protected, limit 3); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 3); skin: 11.2 nTPM (manageable, limit 5); retina: 11.1 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 3); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 3); tongue: 9.7 nTPM (protected, limit 3); lung: 9.6 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 3); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112282,MED23,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8966% (minimum 80%, Supported); adrenal gland: 78.5714% (minimum 97%, Supported); amygdala: 70.2128% (minimum 99%, Missing); basal ganglia: 12.9412% (minimum 99%, Missing); cerebellum: 44.0000% (minimum 99%, Missing); cerebral cortex: 68.7500% (minimum 97%, Supported); choroid plexus: 94.2857% (minimum 99%, Missing); colon: 78.5714% (minimum 90%, Supported); duodenum: 94.2857% (minimum 97%, Supported); esophagus: 89.1892% (minimum 90%, Supported); heart muscle: 48.5294% (minimum 97%, Supported); hippocampal formation: 63.4615% (minimum 99%, Missing); hypothalamus: 61.1111% (minimum 99%, Missing); kidney: 53.2258% (minimum 99%, Missing); liver: 91.6667% (minimum 97%, Supported); lung: 76.7442% (minimum 97%, Supported); lymph node: 94.2857% (minimum 97%, Missing); midbrain: 70.2128% (minimum 99%, Missing); pancreas: 86.8421% (minimum 97%, Supported); parathyroid gland: 89.1892% (minimum 90%, Supported); pituitary gland: 55.9322% (minimum 99%, Missing); retina: 63.4615% (minimum 99%, Missing); salivary gland: 89.1892% (minimum 90%, Supported); skeletal muscle: 91.6667% (minimum 97%, Supported); small intestine: 82.5000% (minimum 97%, Supported); smooth muscle: 67.3469% (minimum 97%, Supported); spinal cord: 80.4878% (minimum 99%, Missing); spleen: 73.3333% (minimum 80%, Supported); stomach: 75.0000% (minimum 97%, Missing); thyroid gland: 49.2537% (minimum 80%, Supported); tongue: 94.2857% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 90%, Supported)",-0.307463,-0.3,-0.860588,0,10,partial,22.2,2.2,3.4,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112541,PDE10A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 70.2128% (minimum 75%, Missing); basal ganglia: 12.9412% (minimum 75%, Missing); cerebellum: 44.0000% (minimum 75%, Missing); heart muscle: 48.5294% (minimum 65%, Supported); hippocampal formation: 63.4615% (minimum 75%, Missing); hypothalamus: 61.1111% (minimum 75%, Missing); kidney: 53.2258% (minimum 75%, Missing); midbrain: 70.2128% (minimum 75%, Missing); pituitary gland: 55.9322% (minimum 75%, Missing); retina: 63.4615% (minimum 75%, Missing); thyroid gland: 49.2537% (minimum 55%, Supported)",-0.0574627,0,-0.620588,0,10,partial,22.2,2.2,3.4,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112541,PDE10A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 70.2128% (minimum 75%, Missing); basal ganglia: 12.9412% (minimum 75%, Missing); cerebellum: 44.0000% (minimum 75%, Missing); heart muscle: 48.5294% (minimum 65%, Supported); hippocampal formation: 63.4615% (minimum 75%, Missing); hypothalamus: 61.1111% (minimum 75%, Missing); kidney: 53.2258% (minimum 75%, Missing); midbrain: 70.2128% (minimum 75%, Missing); pituitary gland: 55.9322% (minimum 75%, Missing); retina: 63.4615% (minimum 75%, Missing); thyroid gland: 49.2537% (minimum 55%, Supported)",-0.0574627,0,-0.620588,0,10,partial,22.2,2.2,3.4,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112541,PDE10A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 70.2128% (minimum 75%, Missing); basal ganglia: 12.9412% (minimum 75%, Missing); cerebellum: 44.0000% (minimum 75%, Missing); heart muscle: 48.5294% (minimum 65%, Supported); hippocampal formation: 63.4615% (minimum 75%, Missing); hypothalamus: 61.1111% (minimum 75%, Missing); kidney: 53.2258% (minimum 75%, Missing); midbrain: 70.2128% (minimum 75%, Missing); pituitary gland: 55.9322% (minimum 75%, Missing); retina: 63.4615% (minimum 75%, Missing); thyroid gland: 49.2537% (minimum 55%, Supported)",-0.0574627,0,-0.620588,0,10,partial,22.2,2.2,3.4,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112541,PDE10A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8966% (minimum 65%, Baseline (adaptation disabled)); amygdala: 70.2128% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 12.9412% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 44.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.7500% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 48.5294% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.4615% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.1111% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.2258% (minimum 75%, Baseline (adaptation disabled)); midbrain: 70.2128% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 55.9322% (minimum 75%, Baseline (adaptation disabled)); retina: 63.4615% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.3469% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 49.2537% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 70%, Baseline (adaptation disabled))",-0.157463,-0.1,-0.620588,0,10,partial,22.2,2.2,3.4,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112541,PDE10A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 83.3333% (minimum 95%, Enhanced); amygdala: 72.9167% (minimum 99%, Missing); basal ganglia: 77.7778% (minimum 99%, Missing); cerebellum: 81.3953% (minimum 95%, Enhanced); cerebral cortex: 48.6111% (minimum 95%, Enhanced); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 61.4035% (minimum 80%, Enhanced); duodenum: 89.7436% (minimum 95%, Enhanced); heart muscle: 70.0000% (minimum 95%, Enhanced); hippocampal formation: 76.0870% (minimum 99%, Missing); hypothalamus: 60.3448% (minimum 99%, Missing); kidney: 72.9167% (minimum 95%, Enhanced); liver: 94.5946% (minimum 95%, Enhanced); lung: 71.4286% (minimum 95%, Enhanced); midbrain: 77.7778% (minimum 99%, Missing); pancreas: 61.4035% (minimum 95%, Enhanced); parathyroid gland: 46.0526% (minimum 80%, Enhanced); pituitary gland: 59.3220% (minimum 99%, Missing); retina: 0.5596% (minimum 99%, Missing); skeletal muscle: 21.4724% (minimum 95%, Enhanced); small intestine: 71.4286% (minimum 95%, Enhanced); smooth muscle: 66.0377% (minimum 95%, Enhanced); spinal cord: 85.3659% (minimum 99%, Missing); stomach: 74.4681% (minimum 80%, Enhanced); thymus: 94.5946% (minimum 95%, Missing); thyroid gland: 46.6667% (minimum 60%, Enhanced); tongue: 55.5556% (minimum 97%, Missing); urinary bladder: 76.0870% (minimum 80%, Enhanced)",-0.133333,-0.414444,-0.984404,0,1,partial,621.9,4.1,4,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 6); tongue: 2.8 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112619,PRPH2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 72.9167% (minimum 75%, Missing); cerebral cortex: 48.6111% (minimum 60%, Enhanced); hypothalamus: 60.3448% (minimum 75%, Missing); parathyroid gland: 46.0526% (minimum 55%, Enhanced); pituitary gland: 59.3220% (minimum 75%, Missing); retina: 0.5596% (minimum 75%, Missing); skeletal muscle: 21.4724% (minimum 60%, Enhanced); thyroid gland: 46.6667% (minimum 50%, Enhanced); tongue: 55.5556% (minimum 70%, Missing)",-0.0333333,-0.144444,-0.744404,0,1,partial,621.9,4.1,4,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 6); tongue: 2.8 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112619,PRPH2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 72.9167% (minimum 75%, Missing); cerebral cortex: 48.6111% (minimum 60%, Enhanced); hypothalamus: 60.3448% (minimum 75%, Missing); parathyroid gland: 46.0526% (minimum 55%, Enhanced); pituitary gland: 59.3220% (minimum 75%, Missing); retina: 0.5596% (minimum 75%, Missing); skeletal muscle: 21.4724% (minimum 60%, Enhanced); thyroid gland: 46.6667% (minimum 50%, Enhanced); tongue: 55.5556% (minimum 70%, Missing)",-0.0333333,-0.144444,-0.744404,0,1,partial,621.9,4.1,4,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 6); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112619,PRPH2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 72.9167% (minimum 75%, Missing); cerebral cortex: 48.6111% (minimum 60%, Enhanced); hypothalamus: 60.3448% (minimum 75%, Missing); parathyroid gland: 46.0526% (minimum 55%, Enhanced); pituitary gland: 59.3220% (minimum 75%, Missing); retina: 0.5596% (minimum 75%, Missing); skeletal muscle: 21.4724% (minimum 60%, Enhanced); thyroid gland: 46.6667% (minimum 50%, Enhanced); tongue: 55.5556% (minimum 70%, Missing)",-0.0333333,-0.144444,-0.744404,0,1,partial,621.9,4.1,4,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 6); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112619,PRPH2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 72.9167% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.6111% (minimum 75%, Baseline (adaptation disabled)); colon: 61.4035% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.3448% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.9167% (minimum 75%, Baseline (adaptation disabled)); lung: 71.4286% (minimum 75%, Baseline (adaptation disabled)); pancreas: 61.4035% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 46.0526% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 59.3220% (minimum 75%, Baseline (adaptation disabled)); retina: 0.5596% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 21.4724% (minimum 75%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.0377% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 46.6667% (minimum 65%, Baseline (adaptation disabled)); tongue: 55.5556% (minimum 70%, Baseline (adaptation disabled))",-0.183333,-0.239474,-0.744404,0,1,partial,621.9,4.1,4,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 3); cerebral cortex: 3.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112619,PRPH2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.1184% (minimum 99%, Missing); cerebral cortex: 98.8131% (minimum 99%, Missing); colon: 87.6316% (minimum 97%, Missing); duodenum: 89.5161% (minimum 99%, Missing); esophagus: 87.8628% (minimum 97%, Missing); lung: 97.6540% (minimum 99%, Missing); lymph node: 80.8252% (minimum 97%, Missing); rectum: 85.3846% (minimum 97%, Missing); retina: 94.8718% (minimum 99%, Missing); skin: 90.2439% (minimum 95%, Missing); small intestine: 89.2761% (minimum 99%, Missing); stomach: 91.2329% (minimum 97%, Missing); thymus: 42.3126% (minimum 95%, Missing); urinary bladder: 96.5217% (minimum 97%, Missing)",-0.526874,-0.161748,-0.418816,0,1,partial,25,7.9,45.4,"thymus: 45.4 nTPM (manageable, limit 5); bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); rectum: 5.7 nTPM (protected, limit 2); colon: 4.7 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112742,TTK,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.1184% (minimum 75%, Missing); thymus: 42.3126% (minimum 65%, Missing)",-0.226874,0.108252,-0.178816,0,1,partial,25,7.9,45.4,"thymus: 45.4 nTPM (manageable, limit 5); bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); rectum: 5.7 nTPM (protected, limit 2); colon: 4.7 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112742,TTK,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.1184% (minimum 75%, Missing); thymus: 42.3126% (minimum 65%, Missing)",-0.226874,0.108252,-0.178816,0,1,partial,25,7.9,45.4,"thymus: 45.4 nTPM (manageable, limit 5); bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); rectum: 5.7 nTPM (protected, limit 3); colon: 4.7 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); retina: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112742,TTK,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.1184% (minimum 75%, Missing); thymus: 42.3126% (minimum 65%, Missing)",-0.226874,0.108252,-0.178816,0,1,partial,25,7.9,45.4,"thymus: 45.4 nTPM (manageable, limit 5); bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); rectum: 5.7 nTPM (protected, limit 3); colon: 4.7 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); retina: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112742,TTK,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.1184% (minimum 75%, Baseline (adaptation disabled)); thymus: 42.3126% (minimum 65%, Baseline (adaptation disabled))",-0.226874,0.108252,-0.178816,0,1,partial,25,7.9,45.4,"thymus: 45.4 nTPM (manageable, limit 5); bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); rectum: 5.7 nTPM (protected, limit 3); colon: 4.7 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112742,TTK,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.0588% (minimum 99%, Missing); basal ganglia: 94.2857% (minimum 99%, Missing); cerebellum: 76.1538% (minimum 99%, Missing); cerebral cortex: 97.0588% (minimum 99%, Missing); heart muscle: 97.0588% (minimum 99%, Missing); hippocampal formation: 97.0588% (minimum 99%, Missing); hypothalamus: 96.1165% (minimum 99%, Missing); kidney: 90.0000% (minimum 99%, Missing); liver: 93.3962% (minimum 99%, Missing); midbrain: 97.0588% (minimum 99%, Missing); pituitary gland: 97.0588% (minimum 99%, Missing); skin: 84.6154% (minimum 95%, Missing); small intestine: 98.0198% (minimum 99%, Missing); spinal cord: 96.1165% (minimum 99%, Missing)",-0.103846,0.000588235,-0.228462,0,80,unavailable,3.1,0.3,1.8,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112761,CCN6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.196154,0.270588,0.0115385,0,80,unavailable,3.1,0.3,1.8,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112761,CCN6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.196154,0.270588,0.0115385,0,80,unavailable,3.1,0.3,1.8,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112761,CCN6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.196154,0.270588,0.0115385,0,80,unavailable,3.1,0.3,1.8,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112761,CCN6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.196154,0.270588,0.0115385,0,80,unavailable,3.1,0.3,1.8,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112761,CCN6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.5895% (minimum 99%, Missing); amygdala: 97.4601% (minimum 99%, Missing); basal ganglia: 96.5112% (minimum 99%, Missing); cerebellum: 97.1417% (minimum 99%, Missing); cerebral cortex: 94.3673% (minimum 99%, Missing); choroid plexus: 96.5895% (minimum 99%, Missing); heart muscle: 98.2246% (minimum 99%, Missing); hippocampal formation: 97.4201% (minimum 99%, Missing); hypothalamus: 96.2768% (minimum 99%, Missing); kidney: 91.0448% (minimum 99%, Missing); lung: 96.5503% (minimum 99%, Missing); midbrain: 93.8832% (minimum 99%, Missing); parathyroid gland: 84.1826% (minimum 97%, Missing); pituitary gland: 92.4961% (minimum 99%, Missing); retina: 88.9013% (minimum 99%, Missing); salivary gland: 94.4797% (minimum 97%, Missing); skeletal muscle: 95.8501% (minimum 99%, Missing); spinal cord: 97.6200% (minimum 99%, Missing); thyroid gland: 82.7766% (minimum 95%, Missing); tongue: 96.0048% (minimum 97%, Missing)",-0.122234,-0.128174,-0.100987,0,4,partial,29.7,44.7,49.5,"thyroid gland: 49.5 nTPM (manageable, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 2); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 2); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); pancreas: 9.4 nTPM (vital, limit 6); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 2); heart muscle: 4.3 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112796,ENPP5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.177766,0.141826,0.139013,0,4,partial,29.7,44.7,49.5,"thyroid gland: 49.5 nTPM (manageable, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 2); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 2); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); pancreas: 9.4 nTPM (vital, limit 6); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 2); heart muscle: 4.3 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112796,ENPP5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.177766,0.141826,0.139013,0,4,partial,29.7,44.7,49.5,"thyroid gland: 49.5 nTPM (manageable, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 3); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 3); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 3); pancreas: 9.4 nTPM (vital, limit 6); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 3); heart muscle: 4.3 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112796,ENPP5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.177766,0.141826,0.139013,0,4,partial,29.7,44.7,49.5,"thyroid gland: 49.5 nTPM (manageable, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 3); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 3); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 3); pancreas: 9.4 nTPM (vital, limit 6); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 3); heart muscle: 4.3 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112796,ENPP5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.177766,0.141826,0.139013,0,4,partial,29.7,44.7,49.5,"thyroid gland: 49.5 nTPM (manageable, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 3); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 3); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 3); pancreas: 9.4 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 3); heart muscle: 4.3 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112796,ENPP5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 87.0968% (minimum 95%, Enhanced); amygdala: 83.0769% (minimum 99%, Missing); basal ganglia: 81.8182% (minimum 99%, Missing); cerebellum: 81.8182% (minimum 99%, Missing); cerebral cortex: 55.1020% (minimum 99%, Missing); choroid plexus: 93.1034% (minimum 99%, Missing); colon: 71.0526% (minimum 80%, Enhanced); duodenum: 90.0000% (minimum 95%, Enhanced); heart muscle: 75.0000% (minimum 95%, Enhanced); hippocampal formation: 79.4118% (minimum 99%, Missing); hypothalamus: 87.0968% (minimum 99%, Missing); kidney: 85.7143% (minimum 99%, Missing); lung: 72.0000% (minimum 99%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 84.3750% (minimum 95%, Enhanced); pituitary gland: 76.0563% (minimum 99%, Missing); retina: 80.5970% (minimum 99%, Missing); salivary gland: 77.1429% (minimum 80%, Enhanced); skeletal muscle: 85.7143% (minimum 95%, Enhanced); small intestine: 85.7143% (minimum 95%, Enhanced); smooth muscle: 80.5970% (minimum 95%, Enhanced); spinal cord: 80.5970% (minimum 99%, Missing); thyroid gland: 80.5970% (minimum 95%, Missing); tongue: 81.8182% (minimum 97%, Missing)",-0.14403,-0.151818,-0.43898,0,5,partial,4.4,2.2,2.6,"cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112852,PCDHB2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 55.1020% (minimum 75%, Missing); lung: 72.0000% (minimum 75%, Missing)",0.15597,0.118182,-0.19898,0,5,partial,4.4,2.2,2.6,"cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112852,PCDHB2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 55.1020% (minimum 75%, Missing); lung: 72.0000% (minimum 75%, Missing)",0.15597,0.118182,-0.19898,0,5,partial,4.4,2.2,2.6,"cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112852,PCDHB2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 55.1020% (minimum 75%, Missing); lung: 72.0000% (minimum 75%, Missing)",0.15597,0.118182,-0.19898,0,5,partial,4.4,2.2,2.6,"cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112852,PCDHB2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 55.1020% (minimum 75%, Baseline (adaptation disabled)); lung: 72.0000% (minimum 75%, Baseline (adaptation disabled))",0.025,0.0105263,-0.19898,0,5,partial,4.4,2.2,2.6,"cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000112852,PCDHB2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.3077% (minimum 95%, Missing); adrenal gland: 74.4681% (minimum 99%, Missing); amygdala: 81.3953% (minimum 99%, Missing); basal ganglia: 77.7778% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 99%, Missing); cerebral cortex: 81.3953% (minimum 99%, Missing); colon: 81.3953% (minimum 97%, Missing); duodenum: 92.1053% (minimum 99%, Missing); esophagus: 92.1053% (minimum 97%, Missing); heart muscle: 76.0870% (minimum 99%, Missing); hippocampal formation: 85.3659% (minimum 99%, Missing); hypothalamus: 81.3953% (minimum 99%, Missing); kidney: 76.0870% (minimum 99%, Missing); liver: 97.2222% (minimum 99%, Missing); lung: 77.7778% (minimum 99%, Missing); midbrain: 85.3659% (minimum 99%, Missing); pancreas: 76.0870% (minimum 99%, Missing); parathyroid gland: 68.6275% (minimum 97%, Missing); pituitary gland: 67.3077% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 79.5455% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 85.3659% (minimum 99%, Missing); skin: 85.3659% (minimum 95%, Missing); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 77.7778% (minimum 99%, Missing); spinal cord: 81.3953% (minimum 99%, Missing); spleen: 89.7436% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thyroid gland: 83.3333% (minimum 95%, Missing); tongue: 79.5455% (minimum 97%, Missing); urinary bladder: 83.3333% (minimum 97%, Missing)",-0.276923,-0.283725,-0.316923,0,80,unavailable,1.7,1.6,1.7,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113205,PCDHB3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.4681% (minimum 75%, Missing); parathyroid gland: 68.6275% (minimum 70%, Missing); pituitary gland: 67.3077% (minimum 75%, Missing)",0.0230769,-0.0137255,-0.0769231,0,80,unavailable,1.7,1.6,1.7,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113205,PCDHB3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.4681% (minimum 75%, Missing); parathyroid gland: 68.6275% (minimum 70%, Missing); pituitary gland: 67.3077% (minimum 75%, Missing)",0.0230769,-0.0137255,-0.0769231,0,80,unavailable,1.7,1.6,1.7,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113205,PCDHB3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.4681% (minimum 75%, Missing); parathyroid gland: 68.6275% (minimum 70%, Missing); pituitary gland: 67.3077% (minimum 75%, Missing)",0.0230769,-0.0137255,-0.0769231,0,80,unavailable,1.7,1.6,1.7,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113205,PCDHB3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.4681% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 68.6275% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.3077% (minimum 75%, Baseline (adaptation disabled))",0.0230769,-0.0137255,-0.0769231,0,80,unavailable,1.7,1.6,1.7,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113205,PCDHB3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.8182% (minimum 90%, Approved); adrenal gland: 79.7468% (minimum 98%, Approved); amygdala: 70.0000% (minimum 99%, Missing); basal ganglia: 69.2308% (minimum 99%, Missing); cerebellum: 78.7500% (minimum 99%, Missing); cerebral cortex: 61.1650% (minimum 99%, Missing); choroid plexus: 86.3014% (minimum 99%, Missing); colon: 81.8182% (minimum 97%, Missing); duodenum: 96.9231% (minimum 99%, Missing); esophagus: 90.0000% (minimum 95%, Approved); heart muscle: 76.8293% (minimum 99%, Missing); hippocampal formation: 73.2558% (minimum 99%, Missing); hypothalamus: 79.7468% (minimum 99%, Missing); kidney: 73.2558% (minimum 99%, Missing); liver: 90.0000% (minimum 98%, Approved); lung: 78.7500% (minimum 99%, Missing); midbrain: 80.7692% (minimum 99%, Missing); pancreas: 57.7982% (minimum 99%, Missing); parathyroid gland: 70.7865% (minimum 97%, Missing); pituitary gland: 67.0213% (minimum 99%, Missing); rectum: 95.4545% (minimum 97%, Missing); retina: 73.2558% (minimum 99%, Missing); salivary gland: 74.1176% (minimum 97%, Missing); skeletal muscle: 85.1351% (minimum 99%, Missing); skin: 91.3043% (minimum 95%, Missing); small intestine: 91.3043% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spinal cord: 75.9036% (minimum 99%, Missing); spleen: 90.0000% (minimum 95%, Missing); stomach: 86.3014% (minimum 97%, Missing); thymus: 94.0299% (minimum 95%, Missing); thyroid gland: 71.5909% (minimum 95%, Missing); tongue: 91.3043% (minimum 97%, Missing); urinary bladder: 80.7692% (minimum 97%, Missing)",-0.234091,-0.262135,-0.412018,0,3,partial,4.6,2.6,2.5,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113209,PCDHB5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 69.2308% (minimum 75%, Missing); cerebral cortex: 61.1650% (minimum 75%, Missing); hippocampal formation: 73.2558% (minimum 75%, Missing); kidney: 73.2558% (minimum 75%, Missing); pancreas: 57.7982% (minimum 75%, Missing); pituitary gland: 67.0213% (minimum 75%, Missing); retina: 73.2558% (minimum 75%, Missing)",0.0659091,0.00786517,-0.172018,0,3,partial,4.6,2.6,2.5,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113209,PCDHB5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 69.2308% (minimum 75%, Missing); cerebral cortex: 61.1650% (minimum 75%, Missing); hippocampal formation: 73.2558% (minimum 75%, Missing); kidney: 73.2558% (minimum 75%, Missing); pancreas: 57.7982% (minimum 75%, Missing); pituitary gland: 67.0213% (minimum 75%, Missing); retina: 73.2558% (minimum 75%, Missing)",0.0659091,0.00786517,-0.172018,0,3,partial,4.6,2.6,2.5,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113209,PCDHB5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 69.2308% (minimum 75%, Missing); cerebral cortex: 61.1650% (minimum 75%, Missing); hippocampal formation: 73.2558% (minimum 75%, Missing); kidney: 73.2558% (minimum 75%, Missing); pancreas: 57.7982% (minimum 75%, Missing); pituitary gland: 67.0213% (minimum 75%, Missing); retina: 73.2558% (minimum 75%, Missing)",0.0659091,0.00786517,-0.172018,0,3,partial,4.6,2.6,2.5,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113209,PCDHB5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 70.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 69.2308% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.1650% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.2558% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.2558% (minimum 75%, Baseline (adaptation disabled)); pancreas: 57.7982% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 67.0213% (minimum 75%, Baseline (adaptation disabled)); retina: 73.2558% (minimum 75%, Baseline (adaptation disabled))",0.0659091,0.00786517,-0.172018,0,3,partial,4.6,2.6,2.5,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113209,PCDHB5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Missing); adrenal gland: 76.0000% (minimum 99%, Missing); amygdala: 59.3750% (minimum 99%, Missing); basal ganglia: 55.8824% (minimum 99%, Missing); cerebellum: 57.5758% (minimum 99%, Missing); cerebral cortex: 51.3514% (minimum 99%, Missing); choroid plexus: 95.0000% (minimum 99%, Missing); colon: 73.0769% (minimum 97%, Missing); esophagus: 90.4762% (minimum 97%, Missing); heart muscle: 73.0769% (minimum 99%, Missing); hippocampal formation: 59.3750% (minimum 99%, Missing); hypothalamus: 73.0769% (minimum 99%, Missing); kidney: 76.0000% (minimum 99%, Missing); liver: 95.0000% (minimum 99%, Missing); lung: 76.0000% (minimum 99%, Missing); lymph node: 95.0000% (minimum 97%, Missing); midbrain: 70.3704% (minimum 99%, Missing); pancreas: 79.1667% (minimum 99%, Missing); parathyroid gland: 51.3514% (minimum 97%, Missing); pituitary gland: 65.5172% (minimum 99%, Missing); rectum: 95.0000% (minimum 97%, Missing); retina: 67.8571% (minimum 99%, Missing); salivary gland: 73.0769% (minimum 97%, Missing); skeletal muscle: 86.3636% (minimum 99%, Missing); skin: 73.0769% (minimum 95%, Missing); small intestine: 86.3636% (minimum 99%, Missing); smooth muscle: 67.8571% (minimum 99%, Missing); spinal cord: 63.3333% (minimum 99%, Missing); spleen: 90.4762% (minimum 95%, Missing); stomach: 86.3636% (minimum 97%, Missing); thyroid gland: 82.6087% (minimum 95%, Missing); tongue: 86.3636% (minimum 97%, Missing); urinary bladder: 76.0000% (minimum 97%, Missing)",-0.246296,-0.456486,-0.476486,0,80,unavailable,1.8,1.8,0.8,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113211,PCDHB6,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 59.3750% (minimum 75%, Missing); basal ganglia: 55.8824% (minimum 75%, Missing); cerebellum: 57.5758% (minimum 75%, Missing); cerebral cortex: 51.3514% (minimum 75%, Missing); heart muscle: 73.0769% (minimum 75%, Missing); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 73.0769% (minimum 75%, Missing); midbrain: 70.3704% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 65.5172% (minimum 75%, Missing); retina: 67.8571% (minimum 75%, Missing); smooth muscle: 67.8571% (minimum 75%, Missing); spinal cord: 63.3333% (minimum 75%, Missing)",0.0537037,-0.186486,-0.236486,0,80,unavailable,1.8,1.8,0.8,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113211,PCDHB6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 59.3750% (minimum 75%, Missing); basal ganglia: 55.8824% (minimum 75%, Missing); cerebellum: 57.5758% (minimum 75%, Missing); cerebral cortex: 51.3514% (minimum 75%, Missing); heart muscle: 73.0769% (minimum 75%, Missing); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 73.0769% (minimum 75%, Missing); midbrain: 70.3704% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 65.5172% (minimum 75%, Missing); retina: 67.8571% (minimum 75%, Missing); smooth muscle: 67.8571% (minimum 75%, Missing); spinal cord: 63.3333% (minimum 75%, Missing)",0.0537037,-0.186486,-0.236486,0,80,unavailable,1.8,1.8,0.8,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113211,PCDHB6,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 59.3750% (minimum 75%, Missing); basal ganglia: 55.8824% (minimum 75%, Missing); cerebellum: 57.5758% (minimum 75%, Missing); cerebral cortex: 51.3514% (minimum 75%, Missing); heart muscle: 73.0769% (minimum 75%, Missing); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 73.0769% (minimum 75%, Missing); midbrain: 70.3704% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 65.5172% (minimum 75%, Missing); retina: 67.8571% (minimum 75%, Missing); smooth muscle: 67.8571% (minimum 75%, Missing); spinal cord: 63.3333% (minimum 75%, Missing)",0.0537037,-0.186486,-0.236486,0,80,unavailable,1.8,1.8,0.8,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113211,PCDHB6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 59.3750% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.8824% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.5758% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.3514% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 73.0769% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 59.3750% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.0769% (minimum 75%, Baseline (adaptation disabled)); midbrain: 70.3704% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.3514% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 65.5172% (minimum 75%, Baseline (adaptation disabled)); retina: 67.8571% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.8571% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.3333% (minimum 75%, Baseline (adaptation disabled))",0.0537037,-0.186486,-0.236486,0,80,unavailable,1.8,1.8,0.8,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113211,PCDHB6,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 46.6063% (minimum 99%, Missing); amygdala: 93.2127% (minimum 99%, Missing); basal ganglia: 92.7928% (minimum 99%, Missing); cerebral cortex: 95.3704% (minimum 99%, Missing); choroid plexus: 97.1698% (minimum 99%, Missing); esophagus: 83.4008% (minimum 97%, Missing); heart muscle: 47.5751% (minimum 99%, Missing); hippocampal formation: 91.9643% (minimum 99%, Missing); hypothalamus: 89.1775% (minimum 99%, Missing); lung: 96.2617% (minimum 98%, Approved); midbrain: 91.5556% (minimum 99%, Missing); pituitary gland: 77.7358% (minimum 99%, Missing); rectum: 92.3767% (minimum 95%, Approved); retina: 74.1007% (minimum 99%, Missing); salivary gland: 85.8333% (minimum 95%, Approved); skeletal muscle: 98.0952% (minimum 99%, Missing); small intestine: 95.3704% (minimum 98%, Approved); smooth muscle: 96.2617% (minimum 99%, Missing); spinal cord: 79.2308% (minimum 99%, Missing); thymus: 68.6667% (minimum 95%, Missing); thyroid gland: 92.3767% (minimum 95%, Missing); tongue: 96.2617% (minimum 97%, Missing); urinary bladder: 94.9309% (minimum 95%, Approved)",-0.263333,-0.135992,-0.523937,0,4,partial,23.6,4.1,9.4,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); thymus: 9.4 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113396,SLC27A6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 46.6063% (minimum 75%, Missing); heart muscle: 47.5751% (minimum 75%, Missing); retina: 74.1007% (minimum 75%, Missing)",0.0366667,0.134008,-0.283937,0,4,partial,23.6,4.1,9.4,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); thymus: 9.4 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113396,SLC27A6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 46.6063% (minimum 75%, Missing); heart muscle: 47.5751% (minimum 75%, Missing); retina: 74.1007% (minimum 75%, Missing)",0.0366667,0.134008,-0.283937,0,4,partial,23.6,4.1,9.4,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); thymus: 9.4 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 3); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113396,SLC27A6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 46.6063% (minimum 75%, Missing); heart muscle: 47.5751% (minimum 75%, Missing); retina: 74.1007% (minimum 75%, Missing)",0.0366667,0.134008,-0.283937,0,4,partial,23.6,4.1,9.4,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); thymus: 9.4 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 3); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113396,SLC27A6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 46.6063% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 47.5751% (minimum 75%, Baseline (adaptation disabled)); retina: 74.1007% (minimum 75%, Baseline (adaptation disabled))",0.0366667,0.134008,-0.283937,0,4,partial,23.6,4.1,9.4,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); thymus: 9.4 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113396,SLC27A6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.0000% (minimum 99%, Missing); cerebral cortex: 94.2308% (minimum 98%, Approved); duodenum: 90.7407% (minimum 98%, Approved); heart muscle: 96.0784% (minimum 98%, Approved); liver: 96.0784% (minimum 98%, Approved); midbrain: 98.0000% (minimum 99%, Missing); retina: 96.0784% (minimum 99%, Missing); small intestine: 85.9649% (minimum 98%, Approved)",0.0245283,0.01,-0.120351,0,6,partial,0.8,0.2,0.4,,,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113525,IL5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.324528,0.28,0.159649,0,6,partial,0.8,0.2,0.4,,,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113525,IL5,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.324528,0.28,0.159649,0,6,partial,0.8,0.2,0.4,,,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113525,IL5,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.324528,0.28,0.159649,0,6,partial,0.8,0.2,0.4,,,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113525,IL5,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.274528,0.260784,0.109649,0,6,partial,0.8,0.2,0.4,,,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113525,IL5,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.3878% (minimum 90%, Approved); adrenal gland: 57.6271% (minimum 99%, Missing); amygdala: 62.3853% (minimum 99%, Missing); basal ganglia: 53.1250% (minimum 99%, Missing); bone marrow: 89.4737% (minimum 99%, Missing); cerebellum: 57.1429% (minimum 99%, Missing); cerebral cortex: 46.5753% (minimum 99%, Missing); choroid plexus: 70.8333% (minimum 99%, Missing); colon: 74.7253% (minimum 97%, Missing); duodenum: 85.0000% (minimum 99%, Missing); esophagus: 70.1031% (minimum 97%, Missing); heart muscle: 67.3267% (minimum 99%, Missing); hippocampal formation: 57.6271% (minimum 99%, Missing); hypothalamus: 57.6271% (minimum 99%, Missing); kidney: 48.2270% (minimum 99%, Missing); liver: 73.1183% (minimum 99%, Missing); lung: 58.1197% (minimum 99%, Missing); lymph node: 74.7253% (minimum 97%, Missing); midbrain: 65.3846% (minimum 99%, Missing); pancreas: 67.3267% (minimum 99%, Missing); parathyroid gland: 35.6021% (minimum 97%, Missing); pituitary gland: 62.9630% (minimum 99%, Missing); rectum: 73.9130% (minimum 97%, Missing); retina: 15.5963% (minimum 99%, Missing); salivary gland: 54.8387% (minimum 97%, Missing); skeletal muscle: 82.9268% (minimum 99%, Missing); skin: 70.8333% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 62.3853% (minimum 99%, Missing); spinal cord: 68.6869% (minimum 99%, Missing); spleen: 71.5789% (minimum 95%, Missing); stomach: 70.8333% (minimum 97%, Missing); thymus: 74.7253% (minimum 95%, Missing); thyroid gland: 56.1983% (minimum 95%, Missing); tongue: 76.4045% (minimum 97%, Missing); urinary bladder: 68.6869% (minimum 97%, Missing)",-0.388017,-0.613979,-0.834037,0,2,partial,36.8,12.3,5.3,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113966,ARL6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.6271% (minimum 75%, Missing); amygdala: 62.3853% (minimum 75%, Missing); basal ganglia: 53.1250% (minimum 75%, Missing); cerebellum: 57.1429% (minimum 75%, Missing); cerebral cortex: 46.5753% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); heart muscle: 67.3267% (minimum 75%, Missing); hippocampal formation: 57.6271% (minimum 75%, Missing); hypothalamus: 57.6271% (minimum 75%, Missing); kidney: 48.2270% (minimum 75%, Missing); liver: 73.1183% (minimum 75%, Missing); lung: 58.1197% (minimum 75%, Missing); midbrain: 65.3846% (minimum 75%, Missing); pancreas: 67.3267% (minimum 75%, Missing); parathyroid gland: 35.6021% (minimum 70%, Missing); pituitary gland: 62.9630% (minimum 75%, Missing); retina: 15.5963% (minimum 75%, Missing); salivary gland: 54.8387% (minimum 70%, Missing); smooth muscle: 62.3853% (minimum 75%, Missing); spinal cord: 68.6869% (minimum 75%, Missing); thyroid gland: 56.1983% (minimum 65%, Missing); urinary bladder: 68.6869% (minimum 70%, Missing)",-0.0880165,-0.343979,-0.594037,0,2,partial,36.8,12.3,5.3,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113966,ARL6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.6271% (minimum 75%, Missing); amygdala: 62.3853% (minimum 75%, Missing); basal ganglia: 53.1250% (minimum 75%, Missing); cerebellum: 57.1429% (minimum 75%, Missing); cerebral cortex: 46.5753% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); heart muscle: 67.3267% (minimum 75%, Missing); hippocampal formation: 57.6271% (minimum 75%, Missing); hypothalamus: 57.6271% (minimum 75%, Missing); kidney: 48.2270% (minimum 75%, Missing); liver: 73.1183% (minimum 75%, Missing); lung: 58.1197% (minimum 75%, Missing); midbrain: 65.3846% (minimum 75%, Missing); pancreas: 67.3267% (minimum 75%, Missing); parathyroid gland: 35.6021% (minimum 70%, Missing); pituitary gland: 62.9630% (minimum 75%, Missing); retina: 15.5963% (minimum 75%, Missing); salivary gland: 54.8387% (minimum 70%, Missing); smooth muscle: 62.3853% (minimum 75%, Missing); spinal cord: 68.6869% (minimum 75%, Missing); thyroid gland: 56.1983% (minimum 65%, Missing); urinary bladder: 68.6869% (minimum 70%, Missing)",-0.0880165,-0.343979,-0.594037,0,2,partial,36.8,12.3,5.3,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113966,ARL6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.6271% (minimum 75%, Missing); amygdala: 62.3853% (minimum 75%, Missing); basal ganglia: 53.1250% (minimum 75%, Missing); cerebellum: 57.1429% (minimum 75%, Missing); cerebral cortex: 46.5753% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); heart muscle: 67.3267% (minimum 75%, Missing); hippocampal formation: 57.6271% (minimum 75%, Missing); hypothalamus: 57.6271% (minimum 75%, Missing); kidney: 48.2270% (minimum 75%, Missing); liver: 73.1183% (minimum 75%, Missing); lung: 58.1197% (minimum 75%, Missing); midbrain: 65.3846% (minimum 75%, Missing); pancreas: 67.3267% (minimum 75%, Missing); parathyroid gland: 35.6021% (minimum 70%, Missing); pituitary gland: 62.9630% (minimum 75%, Missing); retina: 15.5963% (minimum 75%, Missing); salivary gland: 54.8387% (minimum 70%, Missing); smooth muscle: 62.3853% (minimum 75%, Missing); spinal cord: 68.6869% (minimum 75%, Missing); thyroid gland: 56.1983% (minimum 65%, Missing); urinary bladder: 68.6869% (minimum 70%, Missing)",-0.0880165,-0.343979,-0.594037,0,2,partial,36.8,12.3,5.3,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113966,ARL6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.6271% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.3853% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 53.1250% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.1429% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 46.5753% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.8333% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 67.3267% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.6271% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 57.6271% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.2270% (minimum 75%, Baseline (adaptation disabled)); liver: 73.1183% (minimum 75%, Baseline (adaptation disabled)); lung: 58.1197% (minimum 75%, Baseline (adaptation disabled)); midbrain: 65.3846% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.3267% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 35.6021% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.9630% (minimum 75%, Baseline (adaptation disabled)); retina: 15.5963% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 54.8387% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 62.3853% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.6869% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 56.1983% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 68.6869% (minimum 70%, Baseline (adaptation disabled))",-0.0880165,-0.343979,-0.594037,0,2,partial,36.8,12.3,5.3,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000113966,ARL6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.7245% (minimum 90%, Approved); adrenal gland: 57.8788% (minimum 99%, Missing); amygdala: 57.7039% (minimum 99%, Missing); basal ganglia: 58.4098% (minimum 99%, Missing); bone marrow: 24.2079% (minimum 99%, Missing); cerebellum: 33.3916% (minimum 99%, Missing); cerebral cortex: 45.5847% (minimum 99%, Missing); choroid plexus: 47.1605% (minimum 99%, Missing); colon: 53.9548% (minimum 97%, Missing); duodenum: 62.0130% (minimum 99%, Missing); esophagus: 48.4772% (minimum 97%, Missing); heart muscle: 53.2033% (minimum 99%, Missing); hippocampal formation: 57.7039% (minimum 99%, Missing); hypothalamus: 52.3288% (minimum 99%, Missing); kidney: 51.2064% (minimum 99%, Missing); liver: 53.8028% (minimum 98%, Approved); lung: 54.7278% (minimum 99%, Missing); lymph node: 47.9899% (minimum 95%, Approved); midbrain: 56.8452% (minimum 99%, Missing); pancreas: 58.0547% (minimum 99%, Missing); parathyroid gland: 48.1108% (minimum 97%, Missing); pituitary gland: 61.4148% (minimum 99%, Missing); rectum: 51.7615% (minimum 97%, Missing); retina: 42.9213% (minimum 99%, Missing); salivary gland: 61.0224% (minimum 97%, Missing); skeletal muscle: 33.8053% (minimum 99%, Missing); skin: 60.6349% (minimum 95%, Missing); small intestine: 59.3168% (minimum 99%, Missing); smooth muscle: 44.8357% (minimum 99%, Missing); spinal cord: 54.5714% (minimum 99%, Missing); spleen: 55.2023% (minimum 95%, Missing); stomach: 56.0117% (minimum 97%, Missing); thymus: 46.9287% (minimum 95%, Missing); thyroid gland: 47.9899% (minimum 95%, Missing); tongue: 36.3810% (minimum 97%, Missing); urinary bladder: 47.1605% (minimum 97%, Missing)",-0.480713,-0.60619,-0.747921,0,6,partial,59.8,33.4,21.6,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 2); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); urinary bladder: 21.4 nTPM (protected, limit 2); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 4); thyroid gland: 20.7 nTPM (manageable, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 2); esophagus: 20.3 nTPM (protected, limit 2); adipose tissue: 20.1 nTPM (manageable, limit 10); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 2); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 2); colon: 16.3 nTPM (protected, limit 2); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); spleen: 15.5 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); midbrain: 14.5 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); skin: 12.4 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114098,ARMC8,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.7245% (minimum 60%, Approved); adrenal gland: 57.8788% (minimum 75%, Missing); amygdala: 57.7039% (minimum 75%, Missing); basal ganglia: 58.4098% (minimum 75%, Missing); bone marrow: 24.2079% (minimum 75%, Missing); cerebellum: 33.3916% (minimum 75%, Missing); cerebral cortex: 45.5847% (minimum 75%, Missing); choroid plexus: 47.1605% (minimum 75%, Missing); colon: 53.9548% (minimum 70%, Missing); duodenum: 62.0130% (minimum 75%, Missing); esophagus: 48.4772% (minimum 70%, Missing); heart muscle: 53.2033% (minimum 75%, Missing); hippocampal formation: 57.7039% (minimum 75%, Missing); hypothalamus: 52.3288% (minimum 75%, Missing); kidney: 51.2064% (minimum 75%, Missing); liver: 53.8028% (minimum 70%, Approved); lung: 54.7278% (minimum 75%, Missing); lymph node: 47.9899% (minimum 65%, Approved); midbrain: 56.8452% (minimum 75%, Missing); pancreas: 58.0547% (minimum 75%, Missing); parathyroid gland: 48.1108% (minimum 70%, Missing); pituitary gland: 61.4148% (minimum 75%, Missing); rectum: 51.7615% (minimum 70%, Missing); retina: 42.9213% (minimum 75%, Missing); salivary gland: 61.0224% (minimum 70%, Missing); skeletal muscle: 33.8053% (minimum 75%, Missing); skin: 60.6349% (minimum 65%, Missing); small intestine: 59.3168% (minimum 75%, Missing); smooth muscle: 44.8357% (minimum 75%, Missing); spinal cord: 54.5714% (minimum 75%, Missing); spleen: 55.2023% (minimum 65%, Missing); stomach: 56.0117% (minimum 70%, Missing); thymus: 46.9287% (minimum 65%, Missing); thyroid gland: 47.9899% (minimum 65%, Missing); tongue: 36.3810% (minimum 70%, Missing); urinary bladder: 47.1605% (minimum 70%, Missing)",-0.180713,-0.33619,-0.507921,0,6,partial,59.8,33.4,21.6,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 2); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); urinary bladder: 21.4 nTPM (protected, limit 2); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 4); thyroid gland: 20.7 nTPM (manageable, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 2); esophagus: 20.3 nTPM (protected, limit 2); adipose tissue: 20.1 nTPM (manageable, limit 10); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 2); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 2); colon: 16.3 nTPM (protected, limit 2); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); spleen: 15.5 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); midbrain: 14.5 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); skin: 12.4 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114098,ARMC8,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.7245% (minimum 60%, Approved); adrenal gland: 57.8788% (minimum 75%, Missing); amygdala: 57.7039% (minimum 75%, Missing); basal ganglia: 58.4098% (minimum 75%, Missing); bone marrow: 24.2079% (minimum 75%, Missing); cerebellum: 33.3916% (minimum 75%, Missing); cerebral cortex: 45.5847% (minimum 75%, Missing); choroid plexus: 47.1605% (minimum 75%, Missing); colon: 53.9548% (minimum 70%, Missing); duodenum: 62.0130% (minimum 75%, Missing); esophagus: 48.4772% (minimum 70%, Missing); heart muscle: 53.2033% (minimum 75%, Missing); hippocampal formation: 57.7039% (minimum 75%, Missing); hypothalamus: 52.3288% (minimum 75%, Missing); kidney: 51.2064% (minimum 75%, Missing); liver: 53.8028% (minimum 70%, Approved); lung: 54.7278% (minimum 75%, Missing); lymph node: 47.9899% (minimum 65%, Approved); midbrain: 56.8452% (minimum 75%, Missing); pancreas: 58.0547% (minimum 75%, Missing); parathyroid gland: 48.1108% (minimum 70%, Missing); pituitary gland: 61.4148% (minimum 75%, Missing); rectum: 51.7615% (minimum 70%, Missing); retina: 42.9213% (minimum 75%, Missing); salivary gland: 61.0224% (minimum 70%, Missing); skeletal muscle: 33.8053% (minimum 75%, Missing); skin: 60.6349% (minimum 65%, Missing); small intestine: 59.3168% (minimum 75%, Missing); smooth muscle: 44.8357% (minimum 75%, Missing); spinal cord: 54.5714% (minimum 75%, Missing); spleen: 55.2023% (minimum 65%, Missing); stomach: 56.0117% (minimum 70%, Missing); thymus: 46.9287% (minimum 65%, Missing); thyroid gland: 47.9899% (minimum 65%, Missing); tongue: 36.3810% (minimum 70%, Missing); urinary bladder: 47.1605% (minimum 70%, Missing)",-0.180713,-0.33619,-0.507921,0,6,partial,59.8,33.4,21.6,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 3); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); urinary bladder: 21.4 nTPM (protected, limit 3); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 4); thyroid gland: 20.7 nTPM (manageable, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 3); esophagus: 20.3 nTPM (protected, limit 3); adipose tissue: 20.1 nTPM (manageable, limit 10); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 3); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 2); colon: 16.3 nTPM (protected, limit 3); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); spleen: 15.5 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); midbrain: 14.5 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); skin: 12.4 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114098,ARMC8,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.7245% (minimum 60%, Approved); adrenal gland: 57.8788% (minimum 75%, Missing); amygdala: 57.7039% (minimum 75%, Missing); basal ganglia: 58.4098% (minimum 75%, Missing); bone marrow: 24.2079% (minimum 75%, Missing); cerebellum: 33.3916% (minimum 75%, Missing); cerebral cortex: 45.5847% (minimum 75%, Missing); choroid plexus: 47.1605% (minimum 75%, Missing); colon: 53.9548% (minimum 70%, Missing); duodenum: 62.0130% (minimum 75%, Missing); esophagus: 48.4772% (minimum 70%, Missing); heart muscle: 53.2033% (minimum 75%, Missing); hippocampal formation: 57.7039% (minimum 75%, Missing); hypothalamus: 52.3288% (minimum 75%, Missing); kidney: 51.2064% (minimum 75%, Missing); liver: 53.8028% (minimum 70%, Approved); lung: 54.7278% (minimum 75%, Missing); lymph node: 47.9899% (minimum 65%, Approved); midbrain: 56.8452% (minimum 75%, Missing); pancreas: 58.0547% (minimum 75%, Missing); parathyroid gland: 48.1108% (minimum 70%, Missing); pituitary gland: 61.4148% (minimum 75%, Missing); rectum: 51.7615% (minimum 70%, Missing); retina: 42.9213% (minimum 75%, Missing); salivary gland: 61.0224% (minimum 70%, Missing); skeletal muscle: 33.8053% (minimum 75%, Missing); skin: 60.6349% (minimum 65%, Missing); small intestine: 59.3168% (minimum 75%, Missing); smooth muscle: 44.8357% (minimum 75%, Missing); spinal cord: 54.5714% (minimum 75%, Missing); spleen: 55.2023% (minimum 65%, Missing); stomach: 56.0117% (minimum 70%, Missing); thymus: 46.9287% (minimum 65%, Missing); thyroid gland: 47.9899% (minimum 65%, Missing); tongue: 36.3810% (minimum 70%, Missing); urinary bladder: 47.1605% (minimum 70%, Missing)",-0.180713,-0.33619,-0.507921,0,6,partial,59.8,33.4,21.6,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 3); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); urinary bladder: 21.4 nTPM (protected, limit 3); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 4); thyroid gland: 20.7 nTPM (manageable, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 3); esophagus: 20.3 nTPM (protected, limit 3); adipose tissue: 20.1 nTPM (manageable, limit 10); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 3); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 2); colon: 16.3 nTPM (protected, limit 3); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); spleen: 15.5 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); midbrain: 14.5 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); skin: 12.4 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114098,ARMC8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.7245% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 57.8788% (minimum 75%, Baseline (adaptation disabled)); amygdala: 57.7039% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.4098% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 24.2079% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 33.3916% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 45.5847% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 47.1605% (minimum 75%, Baseline (adaptation disabled)); colon: 53.9548% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.0130% (minimum 75%, Baseline (adaptation disabled)); esophagus: 48.4772% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 53.2033% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.7039% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 52.3288% (minimum 75%, Baseline (adaptation disabled)); kidney: 51.2064% (minimum 75%, Baseline (adaptation disabled)); liver: 53.8028% (minimum 75%, Baseline (adaptation disabled)); lung: 54.7278% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.9899% (minimum 70%, Baseline (adaptation disabled)); midbrain: 56.8452% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.0547% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 48.1108% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 61.4148% (minimum 75%, Baseline (adaptation disabled)); rectum: 51.7615% (minimum 70%, Baseline (adaptation disabled)); retina: 42.9213% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.0224% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 33.8053% (minimum 75%, Baseline (adaptation disabled)); skin: 60.6349% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.3168% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 44.8357% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 54.5714% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.2023% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.0117% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.9287% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 47.9899% (minimum 65%, Baseline (adaptation disabled)); tongue: 36.3810% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 47.1605% (minimum 70%, Baseline (adaptation disabled))",-0.180713,-0.33619,-0.507921,0,6,partial,59.8,33.4,21.6,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 3); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); urinary bladder: 21.4 nTPM (protected, limit 3); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 3); thyroid gland: 20.7 nTPM (manageable, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 3); esophagus: 20.3 nTPM (protected, limit 3); adipose tissue: 20.1 nTPM (manageable, limit 5); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 3); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 1); colon: 16.3 nTPM (protected, limit 3); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); spleen: 15.5 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); midbrain: 14.5 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); skin: 12.4 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114098,ARMC8,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.3077% (minimum 95%, Enhanced); bone marrow: 63.1579% (minimum 95%, Enhanced); cerebral cortex: 85.7143% (minimum 95%, Enhanced); choroid plexus: 92.3077% (minimum 99%, Missing); duodenum: 92.3077% (minimum 95%, Enhanced); hippocampal formation: 92.3077% (minimum 99%, Missing); kidney: 92.3077% (minimum 95%, Enhanced); liver: 92.3077% (minimum 95%, Enhanced); lung: 92.3077% (minimum 95%, Enhanced); pituitary gland: 92.3077% (minimum 99%, Missing); retina: 0.1104% (minimum 99%, Missing); skeletal muscle: 92.3077% (minimum 95%, Enhanced); small intestine: 92.3077% (minimum 95%, Enhanced); smooth muscle: 92.3077% (minimum 95%, Enhanced); spinal cord: 92.3077% (minimum 99%, Missing); thymus: 92.3077% (minimum 95%, Missing)",-0.0269231,0.03,-0.988896,0,0,routine_complete,1086,0.2,0.4,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114349,GNAT1,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 0.1104% (minimum 75%, Missing)",0.25,0.3,-0.748896,0,0,routine_complete,1086,0.2,0.4,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114349,GNAT1,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 0.1104% (minimum 75%, Missing)",0.25,0.3,-0.748896,0,0,routine_complete,1086,0.2,0.4,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114349,GNAT1,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 0.1104% (minimum 75%, Missing)",0.25,0.3,-0.748896,0,0,routine_complete,1086,0.2,0.4,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114349,GNAT1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 63.1579% (minimum 75%, Baseline (adaptation disabled)); retina: 0.1104% (minimum 75%, Baseline (adaptation disabled))",0.1,0.157143,-0.748896,0,0,routine_complete,1086,0.2,0.4,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114349,GNAT1,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hippocampal formation: 98.7261% (minimum 99%, Missing); pituitary gland: 98.1013% (minimum 99%, Missing)",0.05,0.03,-0.00898734,0,1,partial,0.3,0.1,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114487,MORC1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.231013,0,1,partial,0.3,0.1,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114487,MORC1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.231013,0,1,partial,0.3,0.1,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114487,MORC1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.231013,0,1,partial,0.3,0.1,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114487,MORC1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.29359,0.231013,0,1,partial,0.3,0.1,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114487,MORC1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.6269% (minimum 99%, Missing); pituitary gland: 98.6269% (minimum 99%, Missing)",0.05,0.0261741,-0.00373106,0,3,partial,2.9,14.1,6.8,"salivary gland: 14.1 nTPM (protected, limit 6); basal ganglia: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114547,ROPN1B,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.296174,0.236269,0,3,partial,2.9,14.1,6.8,"salivary gland: 14.1 nTPM (protected, limit 6); basal ganglia: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114547,ROPN1B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.296174,0.236269,0,3,partial,2.9,14.1,6.8,"salivary gland: 14.1 nTPM (protected, limit 6); basal ganglia: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114547,ROPN1B,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.296174,0.236269,0,3,partial,2.9,14.1,6.8,"salivary gland: 14.1 nTPM (protected, limit 6); basal ganglia: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114547,ROPN1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.318387,0.236601,0.236269,0,3,partial,2.9,14.1,6.8,"salivary gland: 14.1 nTPM (protected, limit 3); skin: 6.8 nTPM (manageable, limit 5); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114547,ROPN1B,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.8326% (minimum 99%, Missing); amygdala: 97.2727% (minimum 99%, Missing); basal ganglia: 95.9641% (minimum 99%, Missing); bone marrow: 91.0638% (minimum 99%, Missing); cerebellum: 98.6175% (minimum 99%, Missing); cerebral cortex: 95.1111% (minimum 99%, Missing); choroid plexus: 82.6255% (minimum 99%, Missing); duodenum: 96.3964% (minimum 99%, Missing); esophagus: 95.1111% (minimum 97%, Missing); heart muscle: 97.2727% (minimum 99%, Missing); hippocampal formation: 96.3964% (minimum 99%, Missing); hypothalamus: 96.3964% (minimum 99%, Missing); kidney: 98.1651% (minimum 99%, Missing); lung: 95.1111% (minimum 99%, Missing); lymph node: 95.5357% (minimum 97%, Missing); pancreas: 95.9641% (minimum 99%, Missing); parathyroid gland: 93.0435% (minimum 97%, Missing); pituitary gland: 92.6407% (minimum 99%, Missing); rectum: 96.8326% (minimum 97%, Missing); retina: 88.4298% (minimum 99%, Missing); salivary gland: 96.8326% (minimum 97%, Missing); skeletal muscle: 96.8326% (minimum 99%, Missing); skin: 83.5938% (minimum 95%, Missing); small intestine: 95.9641% (minimum 99%, Missing); stomach: 95.5357% (minimum 97%, Missing); thymus: 84.2520% (minimum 95%, Missing)",-0.114062,-0.0395652,-0.163745,0,80,unavailable,4.5,1.6,4.2,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114656,CFAP92,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.185937,0.230435,0.0762548,0,80,unavailable,4.5,1.6,4.2,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114656,CFAP92,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.185937,0.230435,0.0762548,0,80,unavailable,4.5,1.6,4.2,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114656,CFAP92,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.185937,0.230435,0.0762548,0,80,unavailable,4.5,1.6,4.2,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114656,CFAP92,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.185937,0.230435,0.0762548,0,80,unavailable,4.5,1.6,4.2,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114656,CFAP92,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4286% (minimum 90%, Approved); adrenal gland: 48.0769% (minimum 99%, Missing); amygdala: 55.5556% (minimum 99%, Missing); basal ganglia: 59.5238% (minimum 99%, Missing); bone marrow: 92.5926% (minimum 99%, Missing); cerebellum: 34.2466% (minimum 98%, Approved); cerebral cortex: 51.0204% (minimum 98%, Approved); choroid plexus: 78.1250% (minimum 99%, Missing); colon: 64.1026% (minimum 97%, Missing); duodenum: 75.7576% (minimum 99%, Missing); esophagus: 78.1250% (minimum 97%, Missing); heart muscle: 65.7895% (minimum 99%, Missing); hippocampal formation: 59.5238% (minimum 99%, Missing); hypothalamus: 56.8182% (minimum 99%, Missing); kidney: 59.5238% (minimum 99%, Missing); liver: 53.1915% (minimum 98%, Approved); lung: 67.5676% (minimum 98%, Approved); lymph node: 78.1250% (minimum 95%, Approved); midbrain: 60.9756% (minimum 99%, Missing); pancreas: 51.0204% (minimum 99%, Missing); parathyroid gland: 43.8596% (minimum 97%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); rectum: 69.4444% (minimum 97%, Missing); retina: 28.4091% (minimum 99%, Missing); salivary gland: 59.5238% (minimum 95%, Approved); skeletal muscle: 30.1205% (minimum 98%, Approved); skin: 78.1250% (minimum 95%, Missing); small intestine: 69.4444% (minimum 99%, Missing); smooth muscle: 73.5294% (minimum 99%, Missing); spinal cord: 58.1395% (minimum 99%, Missing); spleen: 71.4286% (minimum 90%, Approved); stomach: 62.5000% (minimum 97%, Missing); thymus: 38.4615% (minimum 95%, Missing); thyroid gland: 62.5000% (minimum 95%, Missing); tongue: 48.0769% (minimum 97%, Missing); urinary bladder: 64.1026% (minimum 97%, Missing)",-0.565385,-0.531404,-0.705909,0,3,partial,6.3,3.2,4,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 2); cerebellum: 4.8 nTPM (vital, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); liver: 2.2 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114739,ACVR2B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 48.0769% (minimum 75%, Missing); amygdala: 55.5556% (minimum 75%, Missing); basal ganglia: 59.5238% (minimum 75%, Missing); cerebellum: 34.2466% (minimum 70%, Approved); cerebral cortex: 51.0204% (minimum 70%, Approved); colon: 64.1026% (minimum 70%, Missing); heart muscle: 65.7895% (minimum 75%, Missing); hippocampal formation: 59.5238% (minimum 75%, Missing); hypothalamus: 56.8182% (minimum 75%, Missing); kidney: 59.5238% (minimum 75%, Missing); liver: 53.1915% (minimum 70%, Approved); lung: 67.5676% (minimum 70%, Approved); midbrain: 60.9756% (minimum 75%, Missing); pancreas: 51.0204% (minimum 75%, Missing); parathyroid gland: 43.8596% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); rectum: 69.4444% (minimum 70%, Missing); retina: 28.4091% (minimum 75%, Missing); salivary gland: 59.5238% (minimum 65%, Approved); skeletal muscle: 30.1205% (minimum 70%, Approved); small intestine: 69.4444% (minimum 75%, Missing); smooth muscle: 73.5294% (minimum 75%, Missing); spinal cord: 58.1395% (minimum 75%, Missing); stomach: 62.5000% (minimum 70%, Missing); thymus: 38.4615% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 48.0769% (minimum 70%, Missing); urinary bladder: 64.1026% (minimum 70%, Missing)",-0.265385,-0.261404,-0.465909,0,3,partial,6.3,3.2,4,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 2); cerebellum: 4.8 nTPM (vital, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); liver: 2.2 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114739,ACVR2B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 48.0769% (minimum 75%, Missing); amygdala: 55.5556% (minimum 75%, Missing); basal ganglia: 59.5238% (minimum 75%, Missing); cerebellum: 34.2466% (minimum 70%, Approved); cerebral cortex: 51.0204% (minimum 70%, Approved); colon: 64.1026% (minimum 70%, Missing); heart muscle: 65.7895% (minimum 75%, Missing); hippocampal formation: 59.5238% (minimum 75%, Missing); hypothalamus: 56.8182% (minimum 75%, Missing); kidney: 59.5238% (minimum 75%, Missing); liver: 53.1915% (minimum 70%, Approved); lung: 67.5676% (minimum 70%, Approved); midbrain: 60.9756% (minimum 75%, Missing); pancreas: 51.0204% (minimum 75%, Missing); parathyroid gland: 43.8596% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); rectum: 69.4444% (minimum 70%, Missing); retina: 28.4091% (minimum 75%, Missing); salivary gland: 59.5238% (minimum 65%, Approved); skeletal muscle: 30.1205% (minimum 70%, Approved); small intestine: 69.4444% (minimum 75%, Missing); smooth muscle: 73.5294% (minimum 75%, Missing); spinal cord: 58.1395% (minimum 75%, Missing); stomach: 62.5000% (minimum 70%, Missing); thymus: 38.4615% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 48.0769% (minimum 70%, Missing); urinary bladder: 64.1026% (minimum 70%, Missing)",-0.265385,-0.261404,-0.465909,0,3,partial,6.3,3.2,4,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 2); cerebellum: 4.8 nTPM (vital, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 3); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); liver: 2.2 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114739,ACVR2B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 48.0769% (minimum 75%, Missing); amygdala: 55.5556% (minimum 75%, Missing); basal ganglia: 59.5238% (minimum 75%, Missing); cerebellum: 34.2466% (minimum 70%, Approved); cerebral cortex: 51.0204% (minimum 70%, Approved); colon: 64.1026% (minimum 70%, Missing); heart muscle: 65.7895% (minimum 75%, Missing); hippocampal formation: 59.5238% (minimum 75%, Missing); hypothalamus: 56.8182% (minimum 75%, Missing); kidney: 59.5238% (minimum 75%, Missing); liver: 53.1915% (minimum 70%, Approved); lung: 67.5676% (minimum 70%, Approved); midbrain: 60.9756% (minimum 75%, Missing); pancreas: 51.0204% (minimum 75%, Missing); parathyroid gland: 43.8596% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); rectum: 69.4444% (minimum 70%, Missing); retina: 28.4091% (minimum 75%, Missing); salivary gland: 59.5238% (minimum 65%, Approved); skeletal muscle: 30.1205% (minimum 70%, Approved); small intestine: 69.4444% (minimum 75%, Missing); smooth muscle: 73.5294% (minimum 75%, Missing); spinal cord: 58.1395% (minimum 75%, Missing); stomach: 62.5000% (minimum 70%, Missing); thymus: 38.4615% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 48.0769% (minimum 70%, Missing); urinary bladder: 64.1026% (minimum 70%, Missing)",-0.265385,-0.261404,-0.465909,0,3,partial,6.3,3.2,4,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 2); cerebellum: 4.8 nTPM (vital, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 3); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); liver: 2.2 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114739,ACVR2B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 48.0769% (minimum 75%, Baseline (adaptation disabled)); amygdala: 55.5556% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 59.5238% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 34.2466% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.0204% (minimum 75%, Baseline (adaptation disabled)); colon: 64.1026% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.7895% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 59.5238% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 56.8182% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.5238% (minimum 75%, Baseline (adaptation disabled)); liver: 53.1915% (minimum 75%, Baseline (adaptation disabled)); lung: 67.5676% (minimum 75%, Baseline (adaptation disabled)); midbrain: 60.9756% (minimum 75%, Baseline (adaptation disabled)); pancreas: 51.0204% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 43.8596% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.4444% (minimum 70%, Baseline (adaptation disabled)); retina: 28.4091% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.5238% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 30.1205% (minimum 75%, Baseline (adaptation disabled)); small intestine: 69.4444% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.5294% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 58.1395% (minimum 75%, Baseline (adaptation disabled)); stomach: 62.5000% (minimum 70%, Baseline (adaptation disabled)); thymus: 38.4615% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.5000% (minimum 65%, Baseline (adaptation disabled)); tongue: 48.0769% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 64.1026% (minimum 70%, Baseline (adaptation disabled))",-0.265385,-0.261404,-0.465909,0,3,partial,6.3,3.2,4,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114739,ACVR2B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.0000% (minimum 99%, Missing); amygdala: 24.7368% (minimum 99%, Missing); basal ganglia: 27.3256% (minimum 99%, Missing); cerebellum: 69.1176% (minimum 99%, Missing); cerebral cortex: 10.6576% (minimum 99%, Missing); choroid plexus: 78.3333% (minimum 99%, Missing); duodenum: 97.9167% (minimum 99%, Missing); heart muscle: 95.9184% (minimum 99%, Missing); hippocampal formation: 15.9864% (minimum 99%, Missing); hypothalamus: 28.4848% (minimum 99%, Missing); kidney: 97.9167% (minimum 99%, Missing); lung: 97.9167% (minimum 99%, Missing); midbrain: 14.9682% (minimum 99%, Missing); pancreas: 32.1918% (minimum 95%, Enhanced); parathyroid gland: 13.8643% (minimum 97%, Missing); pituitary gland: 47.9592% (minimum 99%, Missing); retina: 24.1026% (minimum 99%, Missing); salivary gland: 95.9184% (minimum 97%, Missing); skeletal muscle: 78.3333% (minimum 95%, Enhanced); small intestine: 97.9167% (minimum 99%, Missing); spinal cord: 8.7850% (minimum 99%, Missing); thymus: 64.3836% (minimum 95%, Missing); tongue: 94.0000% (minimum 97%, Missing)",-0.306164,-0.831357,-0.90215,0,3,partial,48.8,29.2,2.6,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 2); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 6); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114757,PEX5L,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 24.7368% (minimum 75%, Missing); basal ganglia: 27.3256% (minimum 75%, Missing); cerebellum: 69.1176% (minimum 75%, Missing); cerebral cortex: 10.6576% (minimum 75%, Missing); hippocampal formation: 15.9864% (minimum 75%, Missing); hypothalamus: 28.4848% (minimum 75%, Missing); midbrain: 14.9682% (minimum 75%, Missing); pancreas: 32.1918% (minimum 60%, Enhanced); parathyroid gland: 13.8643% (minimum 70%, Missing); pituitary gland: 47.9592% (minimum 75%, Missing); retina: 24.1026% (minimum 75%, Missing); spinal cord: 8.7850% (minimum 75%, Missing); thymus: 64.3836% (minimum 65%, Missing)",-0.00616438,-0.561357,-0.66215,0,3,partial,48.8,29.2,2.6,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 2); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 6); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114757,PEX5L,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 24.7368% (minimum 75%, Missing); basal ganglia: 27.3256% (minimum 75%, Missing); cerebellum: 69.1176% (minimum 75%, Missing); cerebral cortex: 10.6576% (minimum 75%, Missing); hippocampal formation: 15.9864% (minimum 75%, Missing); hypothalamus: 28.4848% (minimum 75%, Missing); midbrain: 14.9682% (minimum 75%, Missing); pancreas: 32.1918% (minimum 60%, Enhanced); parathyroid gland: 13.8643% (minimum 70%, Missing); pituitary gland: 47.9592% (minimum 75%, Missing); retina: 24.1026% (minimum 75%, Missing); spinal cord: 8.7850% (minimum 75%, Missing); thymus: 64.3836% (minimum 65%, Missing)",-0.00616438,-0.561357,-0.66215,0,3,partial,48.8,29.2,2.6,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 3); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 6); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114757,PEX5L,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 24.7368% (minimum 75%, Missing); basal ganglia: 27.3256% (minimum 75%, Missing); cerebellum: 69.1176% (minimum 75%, Missing); cerebral cortex: 10.6576% (minimum 75%, Missing); hippocampal formation: 15.9864% (minimum 75%, Missing); hypothalamus: 28.4848% (minimum 75%, Missing); midbrain: 14.9682% (minimum 75%, Missing); pancreas: 32.1918% (minimum 60%, Enhanced); parathyroid gland: 13.8643% (minimum 70%, Missing); pituitary gland: 47.9592% (minimum 75%, Missing); retina: 24.1026% (minimum 75%, Missing); spinal cord: 8.7850% (minimum 75%, Missing); thymus: 64.3836% (minimum 65%, Missing)",-0.00616438,-0.561357,-0.66215,0,3,partial,48.8,29.2,2.6,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 3); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 6); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114757,PEX5L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 24.7368% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 27.3256% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 69.1176% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 10.6576% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 15.9864% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 28.4848% (minimum 75%, Baseline (adaptation disabled)); midbrain: 14.9682% (minimum 75%, Baseline (adaptation disabled)); pancreas: 32.1918% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 13.8643% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 47.9592% (minimum 75%, Baseline (adaptation disabled)); retina: 24.1026% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 8.7850% (minimum 75%, Baseline (adaptation disabled)); thymus: 64.3836% (minimum 65%, Baseline (adaptation disabled))",-0.00616438,-0.561357,-0.66215,0,3,partial,48.8,29.2,2.6,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 3); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114757,PEX5L,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9846% (minimum 90%, Approved); adrenal gland: 60.1660% (minimum 99%, Missing); amygdala: 84.3023% (minimum 99%, Missing); basal ganglia: 80.1105% (minimum 99%, Missing); bone marrow: 49.6575% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 99%, Missing); cerebral cortex: 64.7321% (minimum 99%, Missing); choroid plexus: 67.1296% (minimum 99%, Missing); colon: 55.9846% (minimum 97%, Missing); duodenum: 67.4419% (minimum 99%, Missing); esophagus: 62.7706% (minimum 97%, Missing); heart muscle: 58.4677% (minimum 99%, Missing); hippocampal formation: 86.8263% (minimum 99%, Missing); hypothalamus: 86.8263% (minimum 99%, Missing); kidney: 62.7706% (minimum 99%, Missing); liver: 70.0483% (minimum 99%, Missing); lung: 60.1660% (minimum 99%, Missing); lymph node: 64.4444% (minimum 97%, Missing); midbrain: 83.3333% (minimum 99%, Missing); pancreas: 60.4167% (minimum 99%, Missing); parathyroid gland: 49.8282% (minimum 97%, Missing); pituitary gland: 63.0435% (minimum 99%, Missing); rectum: 68.7204% (minimum 97%, Missing); retina: 70.3883% (minimum 99%, Missing); salivary gland: 54.3071% (minimum 97%, Missing); skeletal muscle: 30.7203% (minimum 98%, Approved); skin: 58.0000% (minimum 95%, Missing); small intestine: 55.5556% (minimum 99%, Missing); smooth muscle: 58.7045% (minimum 98%, Approved); spinal cord: 85.7988% (minimum 99%, Missing); spleen: 59.4262% (minimum 95%, Missing); stomach: 60.4167% (minimum 97%, Missing); thymus: 53.3088% (minimum 95%, Missing); thyroid gland: 53.7037% (minimum 95%, Missing); tongue: 41.6667% (minimum 97%, Missing); urinary bladder: 53.5055% (minimum 95%, Approved)",-0.416912,-0.553333,-0.672797,0,8,partial,32.7,20.3,12.7,"skeletal muscle: 32.7 nTPM (vital, limit 2); tongue: 20.3 nTPM (protected, limit 2); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 2); thymus: 12.7 nTPM (manageable, limit 5); urinary bladder: 12.6 nTPM (protected, limit 4); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); small intestine: 11.6 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 10); colon: 11.4 nTPM (protected, limit 2); skin: 10.5 nTPM (manageable, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 2); spleen: 9.9 nTPM (manageable, limit 5); lung: 9.6 nTPM (vital, limit 1); adrenal gland: 9.6 nTPM (vital, limit 1); pancreas: 9.5 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 2); esophagus: 8.6 nTPM (protected, limit 2); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 2); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114982,KANSL3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9846% (minimum 60%, Approved); adrenal gland: 60.1660% (minimum 75%, Missing); bone marrow: 49.6575% (minimum 75%, Missing); cerebral cortex: 64.7321% (minimum 75%, Missing); choroid plexus: 67.1296% (minimum 75%, Missing); colon: 55.9846% (minimum 70%, Missing); duodenum: 67.4419% (minimum 75%, Missing); esophagus: 62.7706% (minimum 70%, Missing); heart muscle: 58.4677% (minimum 75%, Missing); kidney: 62.7706% (minimum 75%, Missing); liver: 70.0483% (minimum 75%, Missing); lung: 60.1660% (minimum 75%, Missing); lymph node: 64.4444% (minimum 70%, Missing); pancreas: 60.4167% (minimum 75%, Missing); parathyroid gland: 49.8282% (minimum 70%, Missing); pituitary gland: 63.0435% (minimum 75%, Missing); rectum: 68.7204% (minimum 70%, Missing); retina: 70.3883% (minimum 75%, Missing); salivary gland: 54.3071% (minimum 70%, Missing); skeletal muscle: 30.7203% (minimum 70%, Approved); skin: 58.0000% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); smooth muscle: 58.7045% (minimum 70%, Approved); spleen: 59.4262% (minimum 65%, Missing); stomach: 60.4167% (minimum 70%, Missing); thymus: 53.3088% (minimum 65%, Missing); thyroid gland: 53.7037% (minimum 65%, Missing); tongue: 41.6667% (minimum 70%, Missing); urinary bladder: 53.5055% (minimum 65%, Approved)",-0.116912,-0.283333,-0.392797,0,8,partial,32.7,20.3,12.7,"skeletal muscle: 32.7 nTPM (vital, limit 2); tongue: 20.3 nTPM (protected, limit 2); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 2); thymus: 12.7 nTPM (manageable, limit 5); urinary bladder: 12.6 nTPM (protected, limit 4); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); small intestine: 11.6 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 10); colon: 11.4 nTPM (protected, limit 2); skin: 10.5 nTPM (manageable, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 2); spleen: 9.9 nTPM (manageable, limit 5); lung: 9.6 nTPM (vital, limit 1); adrenal gland: 9.6 nTPM (vital, limit 1); pancreas: 9.5 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 2); esophagus: 8.6 nTPM (protected, limit 2); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 2); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114982,KANSL3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9846% (minimum 60%, Approved); adrenal gland: 60.1660% (minimum 75%, Missing); bone marrow: 49.6575% (minimum 75%, Missing); cerebral cortex: 64.7321% (minimum 75%, Missing); choroid plexus: 67.1296% (minimum 75%, Missing); colon: 55.9846% (minimum 70%, Missing); duodenum: 67.4419% (minimum 75%, Missing); esophagus: 62.7706% (minimum 70%, Missing); heart muscle: 58.4677% (minimum 75%, Missing); kidney: 62.7706% (minimum 75%, Missing); liver: 70.0483% (minimum 75%, Missing); lung: 60.1660% (minimum 75%, Missing); lymph node: 64.4444% (minimum 70%, Missing); pancreas: 60.4167% (minimum 75%, Missing); parathyroid gland: 49.8282% (minimum 70%, Missing); pituitary gland: 63.0435% (minimum 75%, Missing); rectum: 68.7204% (minimum 70%, Missing); retina: 70.3883% (minimum 75%, Missing); salivary gland: 54.3071% (minimum 70%, Missing); skeletal muscle: 30.7203% (minimum 70%, Approved); skin: 58.0000% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); smooth muscle: 58.7045% (minimum 70%, Approved); spleen: 59.4262% (minimum 65%, Missing); stomach: 60.4167% (minimum 70%, Missing); thymus: 53.3088% (minimum 65%, Missing); thyroid gland: 53.7037% (minimum 65%, Missing); tongue: 41.6667% (minimum 70%, Missing); urinary bladder: 53.5055% (minimum 65%, Approved)",-0.116912,-0.283333,-0.392797,0,8,partial,32.7,20.3,12.7,"skeletal muscle: 32.7 nTPM (vital, limit 2); tongue: 20.3 nTPM (protected, limit 3); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 3); thymus: 12.7 nTPM (manageable, limit 5); urinary bladder: 12.6 nTPM (protected, limit 4); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); small intestine: 11.6 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 10); colon: 11.4 nTPM (protected, limit 3); skin: 10.5 nTPM (manageable, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 2); spleen: 9.9 nTPM (manageable, limit 5); lung: 9.6 nTPM (vital, limit 1); adrenal gland: 9.6 nTPM (vital, limit 1); pancreas: 9.5 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 3); esophagus: 8.6 nTPM (protected, limit 3); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 3); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114982,KANSL3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9846% (minimum 60%, Approved); adrenal gland: 60.1660% (minimum 75%, Missing); bone marrow: 49.6575% (minimum 75%, Missing); cerebral cortex: 64.7321% (minimum 75%, Missing); choroid plexus: 67.1296% (minimum 75%, Missing); colon: 55.9846% (minimum 70%, Missing); duodenum: 67.4419% (minimum 75%, Missing); esophagus: 62.7706% (minimum 70%, Missing); heart muscle: 58.4677% (minimum 75%, Missing); kidney: 62.7706% (minimum 75%, Missing); liver: 70.0483% (minimum 75%, Missing); lung: 60.1660% (minimum 75%, Missing); lymph node: 64.4444% (minimum 70%, Missing); pancreas: 60.4167% (minimum 75%, Missing); parathyroid gland: 49.8282% (minimum 70%, Missing); pituitary gland: 63.0435% (minimum 75%, Missing); rectum: 68.7204% (minimum 70%, Missing); retina: 70.3883% (minimum 75%, Missing); salivary gland: 54.3071% (minimum 70%, Missing); skeletal muscle: 30.7203% (minimum 70%, Approved); skin: 58.0000% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); smooth muscle: 58.7045% (minimum 70%, Approved); spleen: 59.4262% (minimum 65%, Missing); stomach: 60.4167% (minimum 70%, Missing); thymus: 53.3088% (minimum 65%, Missing); thyroid gland: 53.7037% (minimum 65%, Missing); tongue: 41.6667% (minimum 70%, Missing); urinary bladder: 53.5055% (minimum 65%, Approved)",-0.116912,-0.283333,-0.392797,0,8,partial,32.7,20.3,12.7,"skeletal muscle: 32.7 nTPM (vital, limit 2); tongue: 20.3 nTPM (protected, limit 3); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 3); thymus: 12.7 nTPM (manageable, limit 5); urinary bladder: 12.6 nTPM (protected, limit 4); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); small intestine: 11.6 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 10); colon: 11.4 nTPM (protected, limit 3); skin: 10.5 nTPM (manageable, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 2); spleen: 9.9 nTPM (manageable, limit 5); lung: 9.6 nTPM (vital, limit 1); adrenal gland: 9.6 nTPM (vital, limit 1); pancreas: 9.5 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 3); esophagus: 8.6 nTPM (protected, limit 3); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 3); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114982,KANSL3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9846% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.1660% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 49.6575% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.7321% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.1296% (minimum 75%, Baseline (adaptation disabled)); colon: 55.9846% (minimum 70%, Baseline (adaptation disabled)); duodenum: 67.4419% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.7706% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.4677% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.7706% (minimum 75%, Baseline (adaptation disabled)); liver: 70.0483% (minimum 75%, Baseline (adaptation disabled)); lung: 60.1660% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.4444% (minimum 70%, Baseline (adaptation disabled)); pancreas: 60.4167% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.8282% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.0435% (minimum 75%, Baseline (adaptation disabled)); rectum: 68.7204% (minimum 70%, Baseline (adaptation disabled)); retina: 70.3883% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 54.3071% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 30.7203% (minimum 75%, Baseline (adaptation disabled)); skin: 58.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.5556% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.7045% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.4262% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.4167% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.3088% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.7037% (minimum 65%, Baseline (adaptation disabled)); tongue: 41.6667% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 53.5055% (minimum 70%, Baseline (adaptation disabled))",-0.116912,-0.283333,-0.442797,0,8,partial,32.7,20.3,12.7,"skeletal muscle: 32.7 nTPM (vital, limit 1); tongue: 20.3 nTPM (protected, limit 3); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 3); thymus: 12.7 nTPM (manageable, limit 5); urinary bladder: 12.6 nTPM (protected, limit 3); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); small intestine: 11.6 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); colon: 11.4 nTPM (protected, limit 3); skin: 10.5 nTPM (manageable, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 1); spleen: 9.9 nTPM (manageable, limit 5); lung: 9.6 nTPM (vital, limit 1); adrenal gland: 9.6 nTPM (vital, limit 1); pancreas: 9.5 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 3); esophagus: 8.6 nTPM (protected, limit 3); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 3); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000114982,KANSL3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.1154% (minimum 99%, Missing); basal ganglia: 98.0583% (minimum 99%, Missing); bone marrow: 90.9910% (minimum 99%, Missing); cerebral cortex: 90.9910% (minimum 99%, Missing); esophagus: 43.9130% (minimum 97%, Missing); hippocampal formation: 98.0583% (minimum 99%, Missing); hypothalamus: 96.1905% (minimum 99%, Missing); lung: 81.4516% (minimum 99%, Missing); midbrain: 95.2830% (minimum 99%, Missing); parathyroid gland: 96.1905% (minimum 97%, Missing); pituitary gland: 98.0583% (minimum 99%, Missing); salivary gland: 89.3805% (minimum 97%, Missing); skin: 92.6606% (minimum 95%, Missing); spinal cord: 94.3925% (minimum 99%, Missing); urinary bladder: 28.7749% (minimum 97%, Missing)",-0.0233945,-0.682251,-0.175484,0,80,unavailable,2.3,25,0.8,"urinary bladder: 25 nTPM (protected, limit 2); esophagus: 12.9 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115008,IL1A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 43.9130% (minimum 70%, Missing); urinary bladder: 28.7749% (minimum 70%, Missing)",0.276606,-0.412251,0.0645161,0,80,unavailable,2.3,25,0.8,"urinary bladder: 25 nTPM (protected, limit 2); esophagus: 12.9 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115008,IL1A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 43.9130% (minimum 70%, Missing); urinary bladder: 28.7749% (minimum 70%, Missing)",0.276606,-0.412251,0.0645161,0,80,unavailable,2.3,25,0.8,"urinary bladder: 25 nTPM (protected, limit 3); esophagus: 12.9 nTPM (protected, limit 3); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115008,IL1A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 43.9130% (minimum 70%, Missing); urinary bladder: 28.7749% (minimum 70%, Missing)",0.276606,-0.412251,0.0645161,0,80,unavailable,2.3,25,0.8,"urinary bladder: 25 nTPM (protected, limit 3); esophagus: 12.9 nTPM (protected, limit 3); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115008,IL1A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 43.9130% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 28.7749% (minimum 70%, Baseline (adaptation disabled))",0.276606,-0.412251,0.0645161,0,80,unavailable,2.3,25,0.8,"urinary bladder: 25 nTPM (protected, limit 3); esophagus: 12.9 nTPM (protected, limit 3); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115008,IL1A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.0196% (minimum 95%, Missing); adrenal gland: 76.1905% (minimum 99%, Missing); amygdala: 54.1538% (minimum 99%, Missing); basal ganglia: 52.2255% (minimum 99%, Missing); bone marrow: 57.1429% (minimum 99%, Missing); cerebellum: 49.8584% (minimum 99%, Missing); cerebral cortex: 53.9877% (minimum 99%, Missing); choroid plexus: 81.8605% (minimum 99%, Missing); colon: 49.4382% (minimum 97%, Missing); duodenum: 55.6962% (minimum 99%, Missing); esophagus: 47.1850% (minimum 97%, Missing); heart muscle: 74.5763% (minimum 99%, Missing); hippocampal formation: 54.6584% (minimum 99%, Missing); hypothalamus: 64.7059% (minimum 99%, Missing); kidney: 69.5652% (minimum 99%, Missing); liver: 84.2105% (minimum 99%, Missing); lung: 61.3240% (minimum 99%, Missing); lymph node: 72.1311% (minimum 97%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 72.7273% (minimum 99%, Missing); parathyroid gland: 47.0588% (minimum 97%, Missing); pituitary gland: 76.8559% (minimum 99%, Missing); rectum: 50.2857% (minimum 97%, Missing); retina: 65.4275% (minimum 99%, Missing); salivary gland: 54.8287% (minimum 97%, Missing); skeletal muscle: 42.5121% (minimum 99%, Missing); skin: 59.2593% (minimum 95%, Missing); small intestine: 53.4954% (minimum 99%, Missing); smooth muscle: 74.8936% (minimum 99%, Missing); spinal cord: 71.8367% (minimum 99%, Missing); spleen: 67.9537% (minimum 95%, Missing); stomach: 50.8671% (minimum 97%, Missing); thymus: 74.8936% (minimum 95%, Missing); thyroid gland: 59.6610% (minimum 95%, Missing); tongue: 56.2300% (minimum 97%, Missing); urinary bladder: 56.0510% (minimum 97%, Missing)",-0.357407,-0.499412,-0.564879,0,8,partial,23.8,19.8,12.1,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 2); esophagus: 19.7 nTPM (protected, limit 2); colon: 18 nTPM (protected, limit 2); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 2); stomach: 17 nTPM (protected, limit 2); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); salivary gland: 14.5 nTPM (protected, limit 2); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 2); tongue: 13.7 nTPM (protected, limit 2); bone marrow: 13.2 nTPM (vital, limit 1); skin: 12.1 nTPM (manageable, limit 5); thyroid gland: 11.9 nTPM (manageable, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); spleen: 8.3 nTPM (manageable, limit 5); adipose tissue: 7.9 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 2); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115159,GPD2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 54.1538% (minimum 75%, Missing); basal ganglia: 52.2255% (minimum 75%, Missing); bone marrow: 57.1429% (minimum 75%, Missing); cerebellum: 49.8584% (minimum 75%, Missing); cerebral cortex: 53.9877% (minimum 75%, Missing); colon: 49.4382% (minimum 70%, Missing); duodenum: 55.6962% (minimum 75%, Missing); esophagus: 47.1850% (minimum 70%, Missing); heart muscle: 74.5763% (minimum 75%, Missing); hippocampal formation: 54.6584% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); kidney: 69.5652% (minimum 75%, Missing); lung: 61.3240% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 47.0588% (minimum 70%, Missing); rectum: 50.2857% (minimum 70%, Missing); retina: 65.4275% (minimum 75%, Missing); salivary gland: 54.8287% (minimum 70%, Missing); skeletal muscle: 42.5121% (minimum 75%, Missing); skin: 59.2593% (minimum 65%, Missing); small intestine: 53.4954% (minimum 75%, Missing); smooth muscle: 74.8936% (minimum 75%, Missing); spinal cord: 71.8367% (minimum 75%, Missing); stomach: 50.8671% (minimum 70%, Missing); thyroid gland: 59.6610% (minimum 65%, Missing); tongue: 56.2300% (minimum 70%, Missing); urinary bladder: 56.0510% (minimum 70%, Missing)",-0.0574074,-0.229412,-0.324879,0,8,partial,23.8,19.8,12.1,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 2); esophagus: 19.7 nTPM (protected, limit 2); colon: 18 nTPM (protected, limit 2); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 2); stomach: 17 nTPM (protected, limit 2); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); salivary gland: 14.5 nTPM (protected, limit 2); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 2); tongue: 13.7 nTPM (protected, limit 2); bone marrow: 13.2 nTPM (vital, limit 1); skin: 12.1 nTPM (manageable, limit 5); thyroid gland: 11.9 nTPM (manageable, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); spleen: 8.3 nTPM (manageable, limit 5); adipose tissue: 7.9 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 2); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115159,GPD2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 54.1538% (minimum 75%, Missing); basal ganglia: 52.2255% (minimum 75%, Missing); bone marrow: 57.1429% (minimum 75%, Missing); cerebellum: 49.8584% (minimum 75%, Missing); cerebral cortex: 53.9877% (minimum 75%, Missing); colon: 49.4382% (minimum 70%, Missing); duodenum: 55.6962% (minimum 75%, Missing); esophagus: 47.1850% (minimum 70%, Missing); heart muscle: 74.5763% (minimum 75%, Missing); hippocampal formation: 54.6584% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); kidney: 69.5652% (minimum 75%, Missing); lung: 61.3240% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 47.0588% (minimum 70%, Missing); rectum: 50.2857% (minimum 70%, Missing); retina: 65.4275% (minimum 75%, Missing); salivary gland: 54.8287% (minimum 70%, Missing); skeletal muscle: 42.5121% (minimum 75%, Missing); skin: 59.2593% (minimum 65%, Missing); small intestine: 53.4954% (minimum 75%, Missing); smooth muscle: 74.8936% (minimum 75%, Missing); spinal cord: 71.8367% (minimum 75%, Missing); stomach: 50.8671% (minimum 70%, Missing); thyroid gland: 59.6610% (minimum 65%, Missing); tongue: 56.2300% (minimum 70%, Missing); urinary bladder: 56.0510% (minimum 70%, Missing)",-0.0574074,-0.229412,-0.324879,0,8,partial,23.8,19.8,12.1,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 3); esophagus: 19.7 nTPM (protected, limit 3); colon: 18 nTPM (protected, limit 3); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 3); stomach: 17 nTPM (protected, limit 3); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); salivary gland: 14.5 nTPM (protected, limit 3); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 3); tongue: 13.7 nTPM (protected, limit 3); bone marrow: 13.2 nTPM (vital, limit 1); skin: 12.1 nTPM (manageable, limit 5); thyroid gland: 11.9 nTPM (manageable, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); spleen: 8.3 nTPM (manageable, limit 5); adipose tissue: 7.9 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 3); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115159,GPD2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 54.1538% (minimum 75%, Missing); basal ganglia: 52.2255% (minimum 75%, Missing); bone marrow: 57.1429% (minimum 75%, Missing); cerebellum: 49.8584% (minimum 75%, Missing); cerebral cortex: 53.9877% (minimum 75%, Missing); colon: 49.4382% (minimum 70%, Missing); duodenum: 55.6962% (minimum 75%, Missing); esophagus: 47.1850% (minimum 70%, Missing); heart muscle: 74.5763% (minimum 75%, Missing); hippocampal formation: 54.6584% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); kidney: 69.5652% (minimum 75%, Missing); lung: 61.3240% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 47.0588% (minimum 70%, Missing); rectum: 50.2857% (minimum 70%, Missing); retina: 65.4275% (minimum 75%, Missing); salivary gland: 54.8287% (minimum 70%, Missing); skeletal muscle: 42.5121% (minimum 75%, Missing); skin: 59.2593% (minimum 65%, Missing); small intestine: 53.4954% (minimum 75%, Missing); smooth muscle: 74.8936% (minimum 75%, Missing); spinal cord: 71.8367% (minimum 75%, Missing); stomach: 50.8671% (minimum 70%, Missing); thyroid gland: 59.6610% (minimum 65%, Missing); tongue: 56.2300% (minimum 70%, Missing); urinary bladder: 56.0510% (minimum 70%, Missing)",-0.0574074,-0.229412,-0.324879,0,8,partial,23.8,19.8,12.1,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 3); esophagus: 19.7 nTPM (protected, limit 3); colon: 18 nTPM (protected, limit 3); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 3); stomach: 17 nTPM (protected, limit 3); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); salivary gland: 14.5 nTPM (protected, limit 3); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 3); tongue: 13.7 nTPM (protected, limit 3); bone marrow: 13.2 nTPM (vital, limit 1); skin: 12.1 nTPM (manageable, limit 5); thyroid gland: 11.9 nTPM (manageable, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); spleen: 8.3 nTPM (manageable, limit 5); adipose tissue: 7.9 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 3); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115159,GPD2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 54.1538% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 52.2255% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 57.1429% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 49.8584% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.9877% (minimum 75%, Baseline (adaptation disabled)); colon: 49.4382% (minimum 70%, Baseline (adaptation disabled)); duodenum: 55.6962% (minimum 75%, Baseline (adaptation disabled)); esophagus: 47.1850% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 74.5763% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.6584% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.7059% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.5652% (minimum 75%, Baseline (adaptation disabled)); lung: 61.3240% (minimum 75%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.7273% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 47.0588% (minimum 70%, Baseline (adaptation disabled)); rectum: 50.2857% (minimum 70%, Baseline (adaptation disabled)); retina: 65.4275% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 54.8287% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 42.5121% (minimum 75%, Baseline (adaptation disabled)); skin: 59.2593% (minimum 65%, Baseline (adaptation disabled)); small intestine: 53.4954% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 74.8936% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.8367% (minimum 75%, Baseline (adaptation disabled)); stomach: 50.8671% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 59.6610% (minimum 65%, Baseline (adaptation disabled)); tongue: 56.2300% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.0510% (minimum 70%, Baseline (adaptation disabled))",-0.0574074,-0.229412,-0.324879,0,8,partial,23.8,19.8,12.1,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 3); esophagus: 19.7 nTPM (protected, limit 3); colon: 18 nTPM (protected, limit 3); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 3); stomach: 17 nTPM (protected, limit 3); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); salivary gland: 14.5 nTPM (protected, limit 3); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 3); tongue: 13.7 nTPM (protected, limit 3); bone marrow: 13.2 nTPM (vital, limit 1); skin: 12.1 nTPM (manageable, limit 5); thyroid gland: 11.9 nTPM (manageable, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); spleen: 8.3 nTPM (manageable, limit 5); adipose tissue: 7.9 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 3); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115159,GPD2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 88.0000% (minimum 95%, Enhanced); bone marrow: 37.2881% (minimum 99%, Missing); cerebral cortex: 91.6667% (minimum 95%, Enhanced); colon: 43.1373% (minimum 97%, Missing); duodenum: 35.4839% (minimum 99%, Missing); esophagus: 38.5965% (minimum 97%, Missing); heart muscle: 91.6667% (minimum 95%, Enhanced); kidney: 95.6522% (minimum 99%, Missing); liver: 91.6667% (minimum 95%, Enhanced); lung: 84.6154% (minimum 95%, Enhanced); lymph node: 23.4043% (minimum 97%, Missing); rectum: 45.8333% (minimum 97%, Missing); salivary gland: 78.5714% (minimum 80%, Enhanced); skin: 38.5965% (minimum 95%, Missing); small intestine: 44.0000% (minimum 99%, Missing); smooth muscle: 73.3333% (minimum 95%, Enhanced); spleen: 52.3810% (minimum 95%, Missing); stomach: 57.8947% (minimum 97%, Missing); thymus: 14.4737% (minimum 95%, Missing); urinary bladder: 75.8621% (minimum 97%, Missing)",-0.805263,-0.735957,-0.635161,0,11,partial,4,7.2,13,"thymus: 13 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115163,CENPA,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.2881% (minimum 75%, Missing); colon: 43.1373% (minimum 70%, Missing); duodenum: 35.4839% (minimum 75%, Missing); esophagus: 38.5965% (minimum 70%, Missing); lymph node: 23.4043% (minimum 70%, Missing); rectum: 45.8333% (minimum 70%, Missing); skin: 38.5965% (minimum 65%, Missing); small intestine: 44.0000% (minimum 75%, Missing); spleen: 52.3810% (minimum 65%, Missing); stomach: 57.8947% (minimum 70%, Missing); thymus: 14.4737% (minimum 65%, Missing)",-0.505263,-0.465957,-0.395161,0,11,partial,4,7.2,13,"thymus: 13 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115163,CENPA,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.2881% (minimum 75%, Missing); colon: 43.1373% (minimum 70%, Missing); duodenum: 35.4839% (minimum 75%, Missing); esophagus: 38.5965% (minimum 70%, Missing); lymph node: 23.4043% (minimum 70%, Missing); rectum: 45.8333% (minimum 70%, Missing); skin: 38.5965% (minimum 65%, Missing); small intestine: 44.0000% (minimum 75%, Missing); spleen: 52.3810% (minimum 65%, Missing); stomach: 57.8947% (minimum 70%, Missing); thymus: 14.4737% (minimum 65%, Missing)",-0.505263,-0.465957,-0.395161,0,11,partial,4,7.2,13,"thymus: 13 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115163,CENPA,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.2881% (minimum 75%, Missing); colon: 43.1373% (minimum 70%, Missing); duodenum: 35.4839% (minimum 75%, Missing); esophagus: 38.5965% (minimum 70%, Missing); lymph node: 23.4043% (minimum 70%, Missing); rectum: 45.8333% (minimum 70%, Missing); skin: 38.5965% (minimum 65%, Missing); small intestine: 44.0000% (minimum 75%, Missing); spleen: 52.3810% (minimum 65%, Missing); stomach: 57.8947% (minimum 70%, Missing); thymus: 14.4737% (minimum 65%, Missing)",-0.505263,-0.465957,-0.395161,0,11,partial,4,7.2,13,"thymus: 13 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115163,CENPA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.2881% (minimum 75%, Baseline (adaptation disabled)); colon: 43.1373% (minimum 70%, Baseline (adaptation disabled)); duodenum: 35.4839% (minimum 75%, Baseline (adaptation disabled)); esophagus: 38.5965% (minimum 70%, Baseline (adaptation disabled)); lymph node: 23.4043% (minimum 70%, Baseline (adaptation disabled)); rectum: 45.8333% (minimum 70%, Baseline (adaptation disabled)); skin: 38.5965% (minimum 65%, Baseline (adaptation disabled)); small intestine: 44.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.3333% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.3810% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.8947% (minimum 70%, Baseline (adaptation disabled)); thymus: 14.4737% (minimum 65%, Baseline (adaptation disabled))",-0.505263,-0.465957,-0.395161,0,11,partial,4,7.2,13,"thymus: 13 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115163,CENPA,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 80.7739% (minimum 99%, Missing); cerebral cortex: 69.8745% (minimum 99%, Missing); choroid plexus: 98.8166% (minimum 99%, Missing); heart muscle: 89.6644% (minimum 95%, Enhanced); hippocampal formation: 85.3129% (minimum 99%, Missing)",0.05,0.03,-0.291255,0,1,partial,28.8,0.5,0.2,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 6)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115194,SLC30A3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 69.8745% (minimum 75%, Missing)",0.35,0.3,-0.0512552,0,1,partial,28.8,0.5,0.2,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 6)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115194,SLC30A3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 69.8745% (minimum 75%, Missing)",0.35,0.3,-0.0512552,0,1,partial,28.8,0.5,0.2,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 6)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115194,SLC30A3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 69.8745% (minimum 75%, Missing)",0.35,0.3,-0.0512552,0,1,partial,28.8,0.5,0.2,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 6)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115194,SLC30A3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 69.8745% (minimum 75%, Baseline (adaptation disabled))",0.347015,0.292571,-0.0512552,0,1,partial,28.8,0.5,0.2,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115194,SLC30A3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 95%, Uncertain); adrenal gland: 54.8780% (minimum 99%, Missing); amygdala: 41.5385% (minimum 99%, Missing); basal ganglia: 40.9091% (minimum 99%, Missing); bone marrow: 48.0427% (minimum 99%, Missing); cerebellum: 59.7345% (minimum 99%, Missing); cerebral cortex: 41.9255% (minimum 99%, Missing); choroid plexus: 48.0427% (minimum 99%, Missing); colon: 64.9038% (minimum 97%, Missing); duodenum: 67.8392% (minimum 99%, Missing); esophagus: 62.2120% (minimum 97%, Missing); heart muscle: 59.4714% (minimum 99%, Missing); hippocampal formation: 46.5517% (minimum 99%, Missing); hypothalamus: 44.4079% (minimum 99%, Missing); kidney: 61.0860% (minimum 99%, Missing); liver: 57.6923% (minimum 99%, Missing); lung: 58.1897% (minimum 99%, Missing); lymph node: 55.7851% (minimum 97%, Missing); midbrain: 39.9408% (minimum 99%, Missing); pancreas: 65.2174% (minimum 99%, Missing); parathyroid gland: 57.4468% (minimum 97%, Missing); pituitary gland: 48.9130% (minimum 99%, Missing); rectum: 63.3803% (minimum 97%, Missing); retina: 37.8151% (minimum 99%, Missing); salivary gland: 61.0860% (minimum 97%, Missing); skeletal muscle: 67.1642% (minimum 99%, Missing); skin: 60.0000% (minimum 95%, Missing); small intestine: 61.9266% (minimum 99%, Missing); smooth muscle: 63.3803% (minimum 99%, Missing); spinal cord: 54.2169% (minimum 99%, Missing); spleen: 52.1236% (minimum 95%, Missing); stomach: 66.1765% (minimum 97%, Missing); thymus: 44.7020% (minimum 95%, Missing); thyroid gland: 54.6559% (minimum 95%, Missing); tongue: 65.2174% (minimum 97%, Missing); urinary bladder: 64.2857% (minimum 97%, Missing)",-0.50298,-0.412149,-0.611849,0,6,partial,22.2,10.7,16.7,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); thymus: 16.7 nTPM (manageable, limit 5); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 2); parathyroid gland: 10 nTPM (protected, limit 2); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 2); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 2); adipose tissue: 8.1 nTPM (manageable, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 2); urinary bladder: 7.5 nTPM (protected, limit 2); colon: 7.3 nTPM (protected, limit 2); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); stomach: 6.9 nTPM (protected, limit 2); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115239,ASB3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 65%, Uncertain); adrenal gland: 54.8780% (minimum 75%, Missing); amygdala: 41.5385% (minimum 75%, Missing); basal ganglia: 40.9091% (minimum 75%, Missing); bone marrow: 48.0427% (minimum 75%, Missing); cerebellum: 59.7345% (minimum 75%, Missing); cerebral cortex: 41.9255% (minimum 75%, Missing); choroid plexus: 48.0427% (minimum 75%, Missing); colon: 64.9038% (minimum 70%, Missing); duodenum: 67.8392% (minimum 75%, Missing); esophagus: 62.2120% (minimum 70%, Missing); heart muscle: 59.4714% (minimum 75%, Missing); hippocampal formation: 46.5517% (minimum 75%, Missing); hypothalamus: 44.4079% (minimum 75%, Missing); kidney: 61.0860% (minimum 75%, Missing); liver: 57.6923% (minimum 75%, Missing); lung: 58.1897% (minimum 75%, Missing); lymph node: 55.7851% (minimum 70%, Missing); midbrain: 39.9408% (minimum 75%, Missing); pancreas: 65.2174% (minimum 75%, Missing); parathyroid gland: 57.4468% (minimum 70%, Missing); pituitary gland: 48.9130% (minimum 75%, Missing); rectum: 63.3803% (minimum 70%, Missing); retina: 37.8151% (minimum 75%, Missing); salivary gland: 61.0860% (minimum 70%, Missing); skeletal muscle: 67.1642% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 61.9266% (minimum 75%, Missing); smooth muscle: 63.3803% (minimum 75%, Missing); spinal cord: 54.2169% (minimum 75%, Missing); spleen: 52.1236% (minimum 65%, Missing); stomach: 66.1765% (minimum 70%, Missing); thymus: 44.7020% (minimum 65%, Missing); thyroid gland: 54.6559% (minimum 65%, Missing); tongue: 65.2174% (minimum 70%, Missing); urinary bladder: 64.2857% (minimum 70%, Missing)",-0.20298,-0.142149,-0.371849,0,6,partial,22.2,10.7,16.7,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); thymus: 16.7 nTPM (manageable, limit 5); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 2); parathyroid gland: 10 nTPM (protected, limit 2); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 2); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 2); adipose tissue: 8.1 nTPM (manageable, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 2); urinary bladder: 7.5 nTPM (protected, limit 2); colon: 7.3 nTPM (protected, limit 2); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); stomach: 6.9 nTPM (protected, limit 2); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115239,ASB3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 65%, Uncertain); adrenal gland: 54.8780% (minimum 75%, Missing); amygdala: 41.5385% (minimum 75%, Missing); basal ganglia: 40.9091% (minimum 75%, Missing); bone marrow: 48.0427% (minimum 75%, Missing); cerebellum: 59.7345% (minimum 75%, Missing); cerebral cortex: 41.9255% (minimum 75%, Missing); choroid plexus: 48.0427% (minimum 75%, Missing); colon: 64.9038% (minimum 70%, Missing); duodenum: 67.8392% (minimum 75%, Missing); esophagus: 62.2120% (minimum 70%, Missing); heart muscle: 59.4714% (minimum 75%, Missing); hippocampal formation: 46.5517% (minimum 75%, Missing); hypothalamus: 44.4079% (minimum 75%, Missing); kidney: 61.0860% (minimum 75%, Missing); liver: 57.6923% (minimum 75%, Missing); lung: 58.1897% (minimum 75%, Missing); lymph node: 55.7851% (minimum 70%, Missing); midbrain: 39.9408% (minimum 75%, Missing); pancreas: 65.2174% (minimum 75%, Missing); parathyroid gland: 57.4468% (minimum 70%, Missing); pituitary gland: 48.9130% (minimum 75%, Missing); rectum: 63.3803% (minimum 70%, Missing); retina: 37.8151% (minimum 75%, Missing); salivary gland: 61.0860% (minimum 70%, Missing); skeletal muscle: 67.1642% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 61.9266% (minimum 75%, Missing); smooth muscle: 63.3803% (minimum 75%, Missing); spinal cord: 54.2169% (minimum 75%, Missing); spleen: 52.1236% (minimum 65%, Missing); stomach: 66.1765% (minimum 70%, Missing); thymus: 44.7020% (minimum 65%, Missing); thyroid gland: 54.6559% (minimum 65%, Missing); tongue: 65.2174% (minimum 70%, Missing); urinary bladder: 64.2857% (minimum 70%, Missing)",-0.20298,-0.142149,-0.371849,0,6,partial,22.2,10.7,16.7,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); thymus: 16.7 nTPM (manageable, limit 5); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 3); parathyroid gland: 10 nTPM (protected, limit 3); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 3); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 3); adipose tissue: 8.1 nTPM (manageable, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 3); urinary bladder: 7.5 nTPM (protected, limit 3); colon: 7.3 nTPM (protected, limit 3); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 3); stomach: 6.9 nTPM (protected, limit 3); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115239,ASB3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 65%, Uncertain); adrenal gland: 54.8780% (minimum 75%, Missing); amygdala: 41.5385% (minimum 75%, Missing); basal ganglia: 40.9091% (minimum 75%, Missing); bone marrow: 48.0427% (minimum 75%, Missing); cerebellum: 59.7345% (minimum 75%, Missing); cerebral cortex: 41.9255% (minimum 75%, Missing); choroid plexus: 48.0427% (minimum 75%, Missing); colon: 64.9038% (minimum 70%, Missing); duodenum: 67.8392% (minimum 75%, Missing); esophagus: 62.2120% (minimum 70%, Missing); heart muscle: 59.4714% (minimum 75%, Missing); hippocampal formation: 46.5517% (minimum 75%, Missing); hypothalamus: 44.4079% (minimum 75%, Missing); kidney: 61.0860% (minimum 75%, Missing); liver: 57.6923% (minimum 75%, Missing); lung: 58.1897% (minimum 75%, Missing); lymph node: 55.7851% (minimum 70%, Missing); midbrain: 39.9408% (minimum 75%, Missing); pancreas: 65.2174% (minimum 75%, Missing); parathyroid gland: 57.4468% (minimum 70%, Missing); pituitary gland: 48.9130% (minimum 75%, Missing); rectum: 63.3803% (minimum 70%, Missing); retina: 37.8151% (minimum 75%, Missing); salivary gland: 61.0860% (minimum 70%, Missing); skeletal muscle: 67.1642% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 61.9266% (minimum 75%, Missing); smooth muscle: 63.3803% (minimum 75%, Missing); spinal cord: 54.2169% (minimum 75%, Missing); spleen: 52.1236% (minimum 65%, Missing); stomach: 66.1765% (minimum 70%, Missing); thymus: 44.7020% (minimum 65%, Missing); thyroid gland: 54.6559% (minimum 65%, Missing); tongue: 65.2174% (minimum 70%, Missing); urinary bladder: 64.2857% (minimum 70%, Missing)",-0.20298,-0.142149,-0.371849,0,6,partial,22.2,10.7,16.7,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); thymus: 16.7 nTPM (manageable, limit 5); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 3); parathyroid gland: 10 nTPM (protected, limit 3); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 3); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 3); adipose tissue: 8.1 nTPM (manageable, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 3); urinary bladder: 7.5 nTPM (protected, limit 3); colon: 7.3 nTPM (protected, limit 3); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 3); stomach: 6.9 nTPM (protected, limit 3); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115239,ASB3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 54.8780% (minimum 75%, Baseline (adaptation disabled)); amygdala: 41.5385% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 40.9091% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 48.0427% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 59.7345% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 41.9255% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 48.0427% (minimum 75%, Baseline (adaptation disabled)); colon: 64.9038% (minimum 70%, Baseline (adaptation disabled)); duodenum: 67.8392% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.2120% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.4714% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 46.5517% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 44.4079% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.0860% (minimum 75%, Baseline (adaptation disabled)); liver: 57.6923% (minimum 75%, Baseline (adaptation disabled)); lung: 58.1897% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.7851% (minimum 70%, Baseline (adaptation disabled)); midbrain: 39.9408% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.2174% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.4468% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 48.9130% (minimum 75%, Baseline (adaptation disabled)); rectum: 63.3803% (minimum 70%, Baseline (adaptation disabled)); retina: 37.8151% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.0860% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 67.1642% (minimum 75%, Baseline (adaptation disabled)); skin: 60.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.9266% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.3803% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 54.2169% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.1236% (minimum 65%, Baseline (adaptation disabled)); stomach: 66.1765% (minimum 70%, Baseline (adaptation disabled)); thymus: 44.7020% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.6559% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.2174% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 64.2857% (minimum 70%, Baseline (adaptation disabled))",-0.20298,-0.142149,-0.371849,0,6,partial,22.2,10.7,16.7,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); thymus: 16.7 nTPM (manageable, limit 5); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 3); parathyroid gland: 10 nTPM (protected, limit 3); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 3); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 3); adipose tissue: 8.1 nTPM (manageable, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 3); urinary bladder: 7.5 nTPM (protected, limit 3); colon: 7.3 nTPM (protected, limit 3); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 3); stomach: 6.9 nTPM (protected, limit 3); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115239,ASB3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.2523% (minimum 95%, Missing); adrenal gland: 89.7906% (minimum 99%, Missing); amygdala: 72.2105% (minimum 99%, Missing); basal ganglia: 90.2632% (minimum 99%, Missing); cerebellum: 48.0392% (minimum 99%, Missing); cerebral cortex: 61.1408% (minimum 99%, Missing); choroid plexus: 90.2632% (minimum 99%, Missing); colon: 75.0547% (minimum 97%, Missing); duodenum: 92.7027% (minimum 99%, Missing); esophagus: 87.7238% (minimum 95%, Approved); heart muscle: 71.1618% (minimum 99%, Missing); hippocampal formation: 67.1233% (minimum 99%, Missing); hypothalamus: 82.2542% (minimum 99%, Missing); kidney: 46.0403% (minimum 99%, Missing); liver: 91.2234% (minimum 99%, Missing); lung: 90.7407% (minimum 99%, Missing); lymph node: 95.0139% (minimum 97%, Missing); midbrain: 82.2542% (minimum 99%, Missing); pancreas: 95.0139% (minimum 99%, Missing); parathyroid gland: 94.7514% (minimum 97%, Missing); pituitary gland: 92.9539% (minimum 99%, Missing); rectum: 85.1117% (minimum 97%, Missing); retina: 96.6197% (minimum 99%, Missing); salivary gland: 94.4904% (minimum 95%, Approved); skeletal muscle: 92.7027% (minimum 99%, Missing); skin: 94.2308% (minimum 95%, Missing); small intestine: 85.9649% (minimum 99%, Missing); smooth muscle: 75.3846% (minimum 98%, Approved); spinal cord: 68.8755% (minimum 99%, Missing); spleen: 93.2065% (minimum 95%, Missing); stomach: 86.3980% (minimum 97%, Missing); thymus: 81.4727% (minimum 95%, Missing); thyroid gland: 45.1910% (minimum 95%, Missing); tongue: 88.8601% (minimum 97%, Missing); urinary bladder: 78.4897% (minimum 97%, Missing)",-0.49809,-0.219453,-0.529597,0,2,partial,40.2,11.4,41.6,"thyroid gland: 41.6 nTPM (manageable, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 2); adipose tissue: 10.1 nTPM (manageable, limit 5); urinary bladder: 9.4 nTPM (protected, limit 2); thymus: 7.8 nTPM (manageable, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 4); tongue: 4.3 nTPM (protected, limit 2); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115252,PDE1A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.2105% (minimum 75%, Missing); cerebellum: 48.0392% (minimum 75%, Missing); cerebral cortex: 61.1408% (minimum 75%, Missing); heart muscle: 71.1618% (minimum 75%, Missing); hippocampal formation: 67.1233% (minimum 75%, Missing); kidney: 46.0403% (minimum 75%, Missing); spinal cord: 68.8755% (minimum 75%, Missing); thyroid gland: 45.1910% (minimum 65%, Missing)",-0.19809,0.050547,-0.289597,0,2,partial,40.2,11.4,41.6,"thyroid gland: 41.6 nTPM (manageable, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 2); adipose tissue: 10.1 nTPM (manageable, limit 5); urinary bladder: 9.4 nTPM (protected, limit 2); thymus: 7.8 nTPM (manageable, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 4); tongue: 4.3 nTPM (protected, limit 2); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115252,PDE1A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.2105% (minimum 75%, Missing); cerebellum: 48.0392% (minimum 75%, Missing); cerebral cortex: 61.1408% (minimum 75%, Missing); heart muscle: 71.1618% (minimum 75%, Missing); hippocampal formation: 67.1233% (minimum 75%, Missing); kidney: 46.0403% (minimum 75%, Missing); spinal cord: 68.8755% (minimum 75%, Missing); thyroid gland: 45.1910% (minimum 65%, Missing)",-0.19809,0.050547,-0.289597,0,2,partial,40.2,11.4,41.6,"thyroid gland: 41.6 nTPM (manageable, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 3); smooth muscle: 11.2 nTPM (vital, limit 2); adipose tissue: 10.1 nTPM (manageable, limit 5); urinary bladder: 9.4 nTPM (protected, limit 3); thymus: 7.8 nTPM (manageable, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 4); tongue: 4.3 nTPM (protected, limit 3); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115252,PDE1A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.2105% (minimum 75%, Missing); cerebellum: 48.0392% (minimum 75%, Missing); cerebral cortex: 61.1408% (minimum 75%, Missing); heart muscle: 71.1618% (minimum 75%, Missing); hippocampal formation: 67.1233% (minimum 75%, Missing); kidney: 46.0403% (minimum 75%, Missing); spinal cord: 68.8755% (minimum 75%, Missing); thyroid gland: 45.1910% (minimum 65%, Missing)",-0.19809,0.050547,-0.289597,0,2,partial,40.2,11.4,41.6,"thyroid gland: 41.6 nTPM (manageable, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 3); smooth muscle: 11.2 nTPM (vital, limit 2); adipose tissue: 10.1 nTPM (manageable, limit 5); urinary bladder: 9.4 nTPM (protected, limit 3); thymus: 7.8 nTPM (manageable, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 4); tongue: 4.3 nTPM (protected, limit 3); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115252,PDE1A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.2105% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.0392% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.1408% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.1618% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.1233% (minimum 75%, Baseline (adaptation disabled)); kidney: 46.0403% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.8755% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 45.1910% (minimum 65%, Baseline (adaptation disabled))",-0.19809,0.050547,-0.289597,0,2,partial,40.2,11.4,41.6,"thyroid gland: 41.6 nTPM (manageable, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 3); smooth muscle: 11.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); urinary bladder: 9.4 nTPM (protected, limit 3); thymus: 7.8 nTPM (manageable, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); tongue: 4.3 nTPM (protected, limit 3); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115252,PDE1A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8626% (minimum 99%, Missing); amygdala: 96.3910% (minimum 99%, Missing); basal ganglia: 95.5291% (minimum 99%, Missing); cerebellum: 98.3129% (minimum 99%, Missing); cerebral cortex: 95.8146% (minimum 99%, Missing); choroid plexus: 97.8626% (minimum 99%, Missing); duodenum: 97.2686% (minimum 99%, Missing); hippocampal formation: 96.2462% (minimum 99%, Missing); hypothalamus: 94.8225% (minimum 99%, Missing); kidney: 94.6824% (minimum 99%, Missing); liver: 94.2647% (minimum 99%, Missing); lung: 98.4639% (minimum 99%, Missing); midbrain: 97.5647% (minimum 99%, Missing); pancreas: 95.9581% (minimum 99%, Missing); pituitary gland: 90.2817% (minimum 99%, Missing); small intestine: 98.3129% (minimum 99%, Missing); spinal cord: 98.0122% (minimum 99%, Missing)",0.00103858,0.00862595,-0.0871831,0,80,unavailable,6.9,1.4,3.3,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115257,PCSK4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.301039,0.278626,0.152817,0,80,unavailable,6.9,1.4,3.3,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115257,PCSK4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.301039,0.278626,0.152817,0,80,unavailable,6.9,1.4,3.3,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115257,PCSK4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.301039,0.278626,0.152817,0,80,unavailable,6.9,1.4,3.3,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115257,PCSK4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.301039,0.278626,0.152817,0,80,unavailable,6.9,1.4,3.3,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115257,PCSK4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.6325% (minimum 95%, Missing); adrenal gland: 61.2352% (minimum 99%, Missing); amygdala: 63.5744% (minimum 99%, Missing); basal ganglia: 64.0110% (minimum 99%, Missing); bone marrow: 69.6562% (minimum 99%, Missing); cerebellum: 56.1446% (minimum 99%, Missing); cerebral cortex: 61.6402% (minimum 99%, Missing); choroid plexus: 75.0403% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 71.2538% (minimum 99%, Missing); esophagus: 60.6771% (minimum 97%, Missing); heart muscle: 70.4992% (minimum 99%, Missing); hippocampal formation: 65.5415% (minimum 99%, Missing); hypothalamus: 65.5415% (minimum 99%, Missing); kidney: 63.6612% (minimum 99%, Missing); liver: 59.8203% (minimum 99%, Missing); lung: 64.9930% (minimum 99%, Missing); lymph node: 71.6923% (minimum 97%, Missing); midbrain: 69.5522% (minimum 99%, Missing); pancreas: 53.3792% (minimum 99%, Missing); parathyroid gland: 71.1450% (minimum 97%, Missing); pituitary gland: 53.2571% (minimum 99%, Missing); rectum: 79.6581% (minimum 97%, Missing); retina: 72.0247% (minimum 99%, Missing); salivary gland: 61.6402% (minimum 97%, Missing); skeletal muscle: 61.6402% (minimum 99%, Missing); skin: 54.0603% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); smooth muscle: 76.6447% (minimum 99%, Missing); spinal cord: 70.2866% (minimum 99%, Missing); spleen: 66.0993% (minimum 95%, Missing); stomach: 59.4388% (minimum 97%, Missing); thymus: 78.8494% (minimum 95%, Missing); thyroid gland: 55.0177% (minimum 95%, Missing); tongue: 84.1155% (minimum 97%, Missing); urinary bladder: 64.0110% (minimum 97%, Missing)",-0.409397,-0.375612,-0.457429,0,80,unavailable,40.9,31.8,39.6,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); skin: 39.6 nTPM (manageable, limit 5); thyroid gland: 38.1 nTPM (manageable, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 2); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 2); adrenal gland: 29.5 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); salivary gland: 29 nTPM (protected, limit 2); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 2); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (manageable, limit 5); lung: 25.1 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); spleen: 23.9 nTPM (manageable, limit 5); colon: 23.3 nTPM (protected, limit 2); small intestine: 23.3 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 2); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 2); retina: 18.1 nTPM (vital, limit 1); choroid plexus: 15.5 nTPM (vital, limit 1); smooth muscle: 14.2 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5); rectum: 11.9 nTPM (protected, limit 2); tongue: 8.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115274,INO80B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.6325% (minimum 65%, Missing); adrenal gland: 61.2352% (minimum 75%, Missing); amygdala: 63.5744% (minimum 75%, Missing); basal ganglia: 64.0110% (minimum 75%, Missing); bone marrow: 69.6562% (minimum 75%, Missing); cerebellum: 56.1446% (minimum 75%, Missing); cerebral cortex: 61.6402% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 71.2538% (minimum 75%, Missing); esophagus: 60.6771% (minimum 70%, Missing); heart muscle: 70.4992% (minimum 75%, Missing); hippocampal formation: 65.5415% (minimum 75%, Missing); hypothalamus: 65.5415% (minimum 75%, Missing); kidney: 63.6612% (minimum 75%, Missing); liver: 59.8203% (minimum 75%, Missing); lung: 64.9930% (minimum 75%, Missing); midbrain: 69.5522% (minimum 75%, Missing); pancreas: 53.3792% (minimum 75%, Missing); pituitary gland: 53.2571% (minimum 75%, Missing); retina: 72.0247% (minimum 75%, Missing); salivary gland: 61.6402% (minimum 70%, Missing); skeletal muscle: 61.6402% (minimum 75%, Missing); skin: 54.0603% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); spinal cord: 70.2866% (minimum 75%, Missing); stomach: 59.4388% (minimum 70%, Missing); thyroid gland: 55.0177% (minimum 65%, Missing); urinary bladder: 64.0110% (minimum 70%, Missing)",-0.109397,-0.105612,-0.217429,0,80,unavailable,40.9,31.8,39.6,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); skin: 39.6 nTPM (manageable, limit 5); thyroid gland: 38.1 nTPM (manageable, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 2); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 2); adrenal gland: 29.5 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); salivary gland: 29 nTPM (protected, limit 2); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 2); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (manageable, limit 5); lung: 25.1 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); spleen: 23.9 nTPM (manageable, limit 5); colon: 23.3 nTPM (protected, limit 2); small intestine: 23.3 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 2); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 2); retina: 18.1 nTPM (vital, limit 1); choroid plexus: 15.5 nTPM (vital, limit 1); smooth muscle: 14.2 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5); rectum: 11.9 nTPM (protected, limit 2); tongue: 8.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115274,INO80B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.6325% (minimum 65%, Missing); adrenal gland: 61.2352% (minimum 75%, Missing); amygdala: 63.5744% (minimum 75%, Missing); basal ganglia: 64.0110% (minimum 75%, Missing); bone marrow: 69.6562% (minimum 75%, Missing); cerebellum: 56.1446% (minimum 75%, Missing); cerebral cortex: 61.6402% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 71.2538% (minimum 75%, Missing); esophagus: 60.6771% (minimum 70%, Missing); heart muscle: 70.4992% (minimum 75%, Missing); hippocampal formation: 65.5415% (minimum 75%, Missing); hypothalamus: 65.5415% (minimum 75%, Missing); kidney: 63.6612% (minimum 75%, Missing); liver: 59.8203% (minimum 75%, Missing); lung: 64.9930% (minimum 75%, Missing); midbrain: 69.5522% (minimum 75%, Missing); pancreas: 53.3792% (minimum 75%, Missing); pituitary gland: 53.2571% (minimum 75%, Missing); retina: 72.0247% (minimum 75%, Missing); salivary gland: 61.6402% (minimum 70%, Missing); skeletal muscle: 61.6402% (minimum 75%, Missing); skin: 54.0603% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); spinal cord: 70.2866% (minimum 75%, Missing); stomach: 59.4388% (minimum 70%, Missing); thyroid gland: 55.0177% (minimum 65%, Missing); urinary bladder: 64.0110% (minimum 70%, Missing)",-0.109397,-0.105612,-0.217429,0,80,unavailable,40.9,31.8,39.6,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); skin: 39.6 nTPM (manageable, limit 5); thyroid gland: 38.1 nTPM (manageable, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 3); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 3); adrenal gland: 29.5 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); salivary gland: 29 nTPM (protected, limit 3); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 3); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (manageable, limit 5); lung: 25.1 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); spleen: 23.9 nTPM (manageable, limit 5); colon: 23.3 nTPM (protected, limit 3); small intestine: 23.3 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 3); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 3); retina: 18.1 nTPM (vital, limit 1); choroid plexus: 15.5 nTPM (vital, limit 1); smooth muscle: 14.2 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5); rectum: 11.9 nTPM (protected, limit 3); tongue: 8.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115274,INO80B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.6325% (minimum 65%, Missing); adrenal gland: 61.2352% (minimum 75%, Missing); amygdala: 63.5744% (minimum 75%, Missing); basal ganglia: 64.0110% (minimum 75%, Missing); bone marrow: 69.6562% (minimum 75%, Missing); cerebellum: 56.1446% (minimum 75%, Missing); cerebral cortex: 61.6402% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 71.2538% (minimum 75%, Missing); esophagus: 60.6771% (minimum 70%, Missing); heart muscle: 70.4992% (minimum 75%, Missing); hippocampal formation: 65.5415% (minimum 75%, Missing); hypothalamus: 65.5415% (minimum 75%, Missing); kidney: 63.6612% (minimum 75%, Missing); liver: 59.8203% (minimum 75%, Missing); lung: 64.9930% (minimum 75%, Missing); midbrain: 69.5522% (minimum 75%, Missing); pancreas: 53.3792% (minimum 75%, Missing); pituitary gland: 53.2571% (minimum 75%, Missing); retina: 72.0247% (minimum 75%, Missing); salivary gland: 61.6402% (minimum 70%, Missing); skeletal muscle: 61.6402% (minimum 75%, Missing); skin: 54.0603% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); spinal cord: 70.2866% (minimum 75%, Missing); stomach: 59.4388% (minimum 70%, Missing); thyroid gland: 55.0177% (minimum 65%, Missing); urinary bladder: 64.0110% (minimum 70%, Missing)",-0.109397,-0.105612,-0.217429,0,80,unavailable,40.9,31.8,39.6,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); skin: 39.6 nTPM (manageable, limit 5); thyroid gland: 38.1 nTPM (manageable, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 3); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 3); adrenal gland: 29.5 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); salivary gland: 29 nTPM (protected, limit 3); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 3); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (manageable, limit 5); lung: 25.1 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); spleen: 23.9 nTPM (manageable, limit 5); colon: 23.3 nTPM (protected, limit 3); small intestine: 23.3 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 3); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 3); retina: 18.1 nTPM (vital, limit 1); choroid plexus: 15.5 nTPM (vital, limit 1); smooth muscle: 14.2 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5); rectum: 11.9 nTPM (protected, limit 3); tongue: 8.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115274,INO80B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.6325% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 61.2352% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.5744% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.0110% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 69.6562% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.1446% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.6402% (minimum 75%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 70%, Baseline (adaptation disabled)); duodenum: 71.2538% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.6771% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.4992% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.5415% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.5415% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.6612% (minimum 75%, Baseline (adaptation disabled)); liver: 59.8203% (minimum 75%, Baseline (adaptation disabled)); lung: 64.9930% (minimum 75%, Baseline (adaptation disabled)); midbrain: 69.5522% (minimum 75%, Baseline (adaptation disabled)); pancreas: 53.3792% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 53.2571% (minimum 75%, Baseline (adaptation disabled)); retina: 72.0247% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.6402% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 61.6402% (minimum 75%, Baseline (adaptation disabled)); skin: 54.0603% (minimum 65%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.2866% (minimum 75%, Baseline (adaptation disabled)); stomach: 59.4388% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 55.0177% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 64.0110% (minimum 70%, Baseline (adaptation disabled))",-0.109397,-0.105612,-0.217429,0,80,unavailable,40.9,31.8,39.6,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); skin: 39.6 nTPM (manageable, limit 5); thyroid gland: 38.1 nTPM (manageable, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 3); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 3); adrenal gland: 29.5 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); salivary gland: 29 nTPM (protected, limit 3); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 3); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (manageable, limit 5); lung: 25.1 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); spleen: 23.9 nTPM (manageable, limit 5); colon: 23.3 nTPM (protected, limit 3); small intestine: 23.3 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 3); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 3); retina: 18.1 nTPM (vital, limit 1); choroid plexus: 15.5 nTPM (vital, limit 1); smooth muscle: 14.2 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5); rectum: 11.9 nTPM (protected, limit 3); tongue: 8.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115274,INO80B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0773% (minimum 95%, Uncertain); adrenal gland: 58.3333% (minimum 99%, Missing); amygdala: 73.6842% (minimum 99%, Missing); basal ganglia: 68.8525% (minimum 99%, Missing); bone marrow: 59.1549% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Uncertain); cerebral cortex: 74.5562% (minimum 99%, Missing); choroid plexus: 43.5986% (minimum 99%, Missing); colon: 58.8785% (minimum 97%, Missing); duodenum: 75.9036% (minimum 99%, Missing); esophagus: 56.7568% (minimum 97%, Missing); heart muscle: 59.1549% (minimum 99%, Uncertain); hippocampal formation: 72.0000% (minimum 99%, Missing); hypothalamus: 71.5909% (minimum 99%, Missing); kidney: 57.5342% (minimum 99%, Missing); liver: 42.7119% (minimum 99%, Missing); lung: 57.0136% (minimum 99%, Missing); lymph node: 47.3684% (minimum 97%, Missing); midbrain: 70.7865% (minimum 99%, Missing); pancreas: 52.9412% (minimum 99%, Uncertain); parathyroid gland: 51.2195% (minimum 97%, Uncertain); pituitary gland: 53.8462% (minimum 99%, Missing); rectum: 68.1081% (minimum 97%, Missing); retina: 60.8696% (minimum 99%, Missing); salivary gland: 56.0000% (minimum 97%, Missing); skeletal muscle: 56.5022% (minimum 99%, Uncertain); skin: 48.4615% (minimum 95%, Missing); small intestine: 57.7982% (minimum 99%, Missing); smooth muscle: 64.2857% (minimum 99%, Missing); spinal cord: 70.3911% (minimum 99%, Missing); spleen: 52.5000% (minimum 95%, Uncertain); stomach: 58.8785% (minimum 97%, Missing); thymus: 56.0000% (minimum 95%, Missing); thyroid gland: 49.0272% (minimum 95%, Uncertain); tongue: 68.1081% (minimum 97%, Missing); urinary bladder: 55.2632% (minimum 97%, Uncertain)",-0.465385,-0.496316,-0.562881,0,1,partial,16.9,14,13.4,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); thyroid gland: 13.1 nTPM (manageable, limit 5); parathyroid gland: 12 nTPM (protected, limit 2); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); urinary bladder: 10.2 nTPM (protected, limit 2); salivary gland: 9.9 nTPM (protected, limit 2); thymus: 9.9 nTPM (manageable, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 2); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); tongue: 5.9 nTPM (protected, limit 2); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115970,THADA,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0773% (minimum 65%, Uncertain); adrenal gland: 58.3333% (minimum 75%, Missing); amygdala: 73.6842% (minimum 75%, Missing); basal ganglia: 68.8525% (minimum 75%, Missing); bone marrow: 59.1549% (minimum 75%, Missing); cerebral cortex: 74.5562% (minimum 75%, Missing); choroid plexus: 43.5986% (minimum 75%, Missing); colon: 58.8785% (minimum 70%, Missing); esophagus: 56.7568% (minimum 70%, Missing); heart muscle: 59.1549% (minimum 75%, Uncertain); hippocampal formation: 72.0000% (minimum 75%, Missing); hypothalamus: 71.5909% (minimum 75%, Missing); kidney: 57.5342% (minimum 75%, Missing); liver: 42.7119% (minimum 75%, Missing); lung: 57.0136% (minimum 75%, Missing); lymph node: 47.3684% (minimum 70%, Missing); midbrain: 70.7865% (minimum 75%, Missing); pancreas: 52.9412% (minimum 75%, Uncertain); parathyroid gland: 51.2195% (minimum 70%, Uncertain); pituitary gland: 53.8462% (minimum 75%, Missing); rectum: 68.1081% (minimum 70%, Missing); retina: 60.8696% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 56.5022% (minimum 75%, Uncertain); skin: 48.4615% (minimum 65%, Missing); small intestine: 57.7982% (minimum 75%, Missing); smooth muscle: 64.2857% (minimum 75%, Missing); spinal cord: 70.3911% (minimum 75%, Missing); spleen: 52.5000% (minimum 65%, Uncertain); stomach: 58.8785% (minimum 70%, Missing); thymus: 56.0000% (minimum 65%, Missing); thyroid gland: 49.0272% (minimum 65%, Uncertain); tongue: 68.1081% (minimum 70%, Missing); urinary bladder: 55.2632% (minimum 70%, Uncertain)",-0.165385,-0.226316,-0.322881,0,1,partial,16.9,14,13.4,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); thyroid gland: 13.1 nTPM (manageable, limit 5); parathyroid gland: 12 nTPM (protected, limit 2); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); urinary bladder: 10.2 nTPM (protected, limit 2); salivary gland: 9.9 nTPM (protected, limit 2); thymus: 9.9 nTPM (manageable, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 2); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); tongue: 5.9 nTPM (protected, limit 2); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115970,THADA,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0773% (minimum 65%, Uncertain); adrenal gland: 58.3333% (minimum 75%, Missing); amygdala: 73.6842% (minimum 75%, Missing); basal ganglia: 68.8525% (minimum 75%, Missing); bone marrow: 59.1549% (minimum 75%, Missing); cerebral cortex: 74.5562% (minimum 75%, Missing); choroid plexus: 43.5986% (minimum 75%, Missing); colon: 58.8785% (minimum 70%, Missing); esophagus: 56.7568% (minimum 70%, Missing); heart muscle: 59.1549% (minimum 75%, Uncertain); hippocampal formation: 72.0000% (minimum 75%, Missing); hypothalamus: 71.5909% (minimum 75%, Missing); kidney: 57.5342% (minimum 75%, Missing); liver: 42.7119% (minimum 75%, Missing); lung: 57.0136% (minimum 75%, Missing); lymph node: 47.3684% (minimum 70%, Missing); midbrain: 70.7865% (minimum 75%, Missing); pancreas: 52.9412% (minimum 75%, Uncertain); parathyroid gland: 51.2195% (minimum 70%, Uncertain); pituitary gland: 53.8462% (minimum 75%, Missing); rectum: 68.1081% (minimum 70%, Missing); retina: 60.8696% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 56.5022% (minimum 75%, Uncertain); skin: 48.4615% (minimum 65%, Missing); small intestine: 57.7982% (minimum 75%, Missing); smooth muscle: 64.2857% (minimum 75%, Missing); spinal cord: 70.3911% (minimum 75%, Missing); spleen: 52.5000% (minimum 65%, Uncertain); stomach: 58.8785% (minimum 70%, Missing); thymus: 56.0000% (minimum 65%, Missing); thyroid gland: 49.0272% (minimum 65%, Uncertain); tongue: 68.1081% (minimum 70%, Missing); urinary bladder: 55.2632% (minimum 70%, Uncertain)",-0.165385,-0.226316,-0.322881,0,1,partial,16.9,14,13.4,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); thyroid gland: 13.1 nTPM (manageable, limit 5); parathyroid gland: 12 nTPM (protected, limit 3); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); urinary bladder: 10.2 nTPM (protected, limit 3); salivary gland: 9.9 nTPM (protected, limit 3); thymus: 9.9 nTPM (manageable, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 3); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); heart muscle: 8.7 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); tongue: 5.9 nTPM (protected, limit 3); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115970,THADA,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0773% (minimum 65%, Uncertain); adrenal gland: 58.3333% (minimum 75%, Missing); amygdala: 73.6842% (minimum 75%, Missing); basal ganglia: 68.8525% (minimum 75%, Missing); bone marrow: 59.1549% (minimum 75%, Missing); cerebral cortex: 74.5562% (minimum 75%, Missing); choroid plexus: 43.5986% (minimum 75%, Missing); colon: 58.8785% (minimum 70%, Missing); esophagus: 56.7568% (minimum 70%, Missing); heart muscle: 59.1549% (minimum 75%, Uncertain); hippocampal formation: 72.0000% (minimum 75%, Missing); hypothalamus: 71.5909% (minimum 75%, Missing); kidney: 57.5342% (minimum 75%, Missing); liver: 42.7119% (minimum 75%, Missing); lung: 57.0136% (minimum 75%, Missing); lymph node: 47.3684% (minimum 70%, Missing); midbrain: 70.7865% (minimum 75%, Missing); pancreas: 52.9412% (minimum 75%, Uncertain); parathyroid gland: 51.2195% (minimum 70%, Uncertain); pituitary gland: 53.8462% (minimum 75%, Missing); rectum: 68.1081% (minimum 70%, Missing); retina: 60.8696% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 56.5022% (minimum 75%, Uncertain); skin: 48.4615% (minimum 65%, Missing); small intestine: 57.7982% (minimum 75%, Missing); smooth muscle: 64.2857% (minimum 75%, Missing); spinal cord: 70.3911% (minimum 75%, Missing); spleen: 52.5000% (minimum 65%, Uncertain); stomach: 58.8785% (minimum 70%, Missing); thymus: 56.0000% (minimum 65%, Missing); thyroid gland: 49.0272% (minimum 65%, Uncertain); tongue: 68.1081% (minimum 70%, Missing); urinary bladder: 55.2632% (minimum 70%, Uncertain)",-0.165385,-0.226316,-0.322881,0,1,partial,16.9,14,13.4,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); thyroid gland: 13.1 nTPM (manageable, limit 5); parathyroid gland: 12 nTPM (protected, limit 3); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); urinary bladder: 10.2 nTPM (protected, limit 3); salivary gland: 9.9 nTPM (protected, limit 3); thymus: 9.9 nTPM (manageable, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 3); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); heart muscle: 8.7 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); tongue: 5.9 nTPM (protected, limit 3); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115970,THADA,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0773% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 58.3333% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.6842% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 68.8525% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 59.1549% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.5562% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 43.5986% (minimum 75%, Baseline (adaptation disabled)); colon: 58.8785% (minimum 70%, Baseline (adaptation disabled)); esophagus: 56.7568% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.1549% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.5909% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.5342% (minimum 75%, Baseline (adaptation disabled)); liver: 42.7119% (minimum 75%, Baseline (adaptation disabled)); lung: 57.0136% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.3684% (minimum 70%, Baseline (adaptation disabled)); midbrain: 70.7865% (minimum 75%, Baseline (adaptation disabled)); pancreas: 52.9412% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.2195% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 53.8462% (minimum 75%, Baseline (adaptation disabled)); rectum: 68.1081% (minimum 70%, Baseline (adaptation disabled)); retina: 60.8696% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 56.5022% (minimum 75%, Baseline (adaptation disabled)); skin: 48.4615% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.7982% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.2857% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.3911% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.5000% (minimum 65%, Baseline (adaptation disabled)); stomach: 58.8785% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 49.0272% (minimum 65%, Baseline (adaptation disabled)); tongue: 68.1081% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 55.2632% (minimum 70%, Baseline (adaptation disabled))",-0.165385,-0.226316,-0.322881,0,1,partial,16.9,14,13.4,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); thyroid gland: 13.1 nTPM (manageable, limit 5); parathyroid gland: 12 nTPM (protected, limit 3); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); urinary bladder: 10.2 nTPM (protected, limit 3); salivary gland: 9.9 nTPM (protected, limit 3); thymus: 9.9 nTPM (manageable, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 3); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); heart muscle: 8.7 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); tongue: 5.9 nTPM (protected, limit 3); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000115970,THADA,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 90.0000% (minimum 95%, Enhanced); pituitary gland: 98.0357% (minimum 99%, Missing); retina: 93.8462% (minimum 99%, Missing)",0.05,0.03,-0.0515385,0,3,partial,6.1,1.5,0.6,"kidney: 6.1 nTPM (vital, limit 6); retina: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116183,PAPPA2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.188462,0,3,partial,6.1,1.5,0.6,"kidney: 6.1 nTPM (vital, limit 6); retina: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116183,PAPPA2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.188462,0,3,partial,6.1,1.5,0.6,"kidney: 6.1 nTPM (vital, limit 6); retina: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116183,PAPPA2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.188462,0,3,partial,6.1,1.5,0.6,"kidney: 6.1 nTPM (vital, limit 6); retina: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116183,PAPPA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339189,0.273404,0.15,0,3,partial,6.1,1.5,0.6,"kidney: 6.1 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116183,PAPPA2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 88.8889% (minimum 95%, Enhanced); amygdala: 97.4790% (minimum 99%, Missing); basal ganglia: 94.8229% (minimum 99%, Missing); bone marrow: 87.3275% (minimum 99%, Missing); cerebellum: 94.5652% (minimum 99%, Missing); cerebral cortex: 94.8229% (minimum 99%, Missing); choroid plexus: 97.8903% (minimum 99%, Missing); colon: 83.8554% (minimum 97%, Missing); duodenum: 86.6750% (minimum 99%, Missing); esophagus: 80.0921% (minimum 97%, Missing); heart muscle: 93.9271% (minimum 99%, Missing); hippocampal formation: 96.3989% (minimum 99%, Missing); hypothalamus: 96.5326% (minimum 99%, Missing); kidney: 91.8206% (minimum 99%, Missing); liver: 70.7317% (minimum 95%, Enhanced); lung: 96.2656% (minimum 99%, Missing); lymph node: 60.5744% (minimum 80%, Enhanced); midbrain: 97.8903% (minimum 99%, Missing); pancreas: 92.9239% (minimum 95%, Enhanced); pituitary gland: 96.1326% (minimum 99%, Missing); rectum: 85.2941% (minimum 97%, Missing); retina: 57.1898% (minimum 99%, Missing); skeletal muscle: 98.1664% (minimum 99%, Missing); skin: 78.8222% (minimum 95%, Missing); small intestine: 81.4035% (minimum 99%, Missing); smooth muscle: 86.3524% (minimum 95%, Enhanced); spinal cord: 98.0282% (minimum 99%, Missing); spleen: 72.4246% (minimum 95%, Missing); thymus: 82.9559% (minimum 95%, Missing); tongue: 92.6764% (minimum 97%, Missing)",-0.225754,-0.194256,-0.418102,0,7,partial,52.1,45.3,26.5,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 12); liver: 28.8 nTPM (vital, limit 6); spleen: 26.5 nTPM (manageable, limit 5); skin: 18.7 nTPM (manageable, limit 5); esophagus: 17.3 nTPM (protected, limit 2); small intestine: 15.9 nTPM (vital, limit 1); thymus: 14.3 nTPM (manageable, limit 5); stomach: 13.5 nTPM (protected, limit 12); colon: 13.4 nTPM (protected, limit 2); urinary bladder: 12.3 nTPM (protected, limit 12); rectum: 12 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 6); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 6); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116191,RALGPS2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 57.1898% (minimum 75%, Missing)",0.0742456,0.0557441,-0.178102,0,7,partial,52.1,45.3,26.5,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 12); liver: 28.8 nTPM (vital, limit 6); spleen: 26.5 nTPM (manageable, limit 5); skin: 18.7 nTPM (manageable, limit 5); esophagus: 17.3 nTPM (protected, limit 2); small intestine: 15.9 nTPM (vital, limit 1); thymus: 14.3 nTPM (manageable, limit 5); stomach: 13.5 nTPM (protected, limit 12); colon: 13.4 nTPM (protected, limit 2); urinary bladder: 12.3 nTPM (protected, limit 12); rectum: 12 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 6); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 6); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116191,RALGPS2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 57.1898% (minimum 75%, Missing)",0.0742456,0.0557441,-0.178102,0,7,partial,52.1,45.3,26.5,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 12); liver: 28.8 nTPM (vital, limit 6); spleen: 26.5 nTPM (manageable, limit 5); skin: 18.7 nTPM (manageable, limit 5); esophagus: 17.3 nTPM (protected, limit 3); small intestine: 15.9 nTPM (vital, limit 1); thymus: 14.3 nTPM (manageable, limit 5); stomach: 13.5 nTPM (protected, limit 12); colon: 13.4 nTPM (protected, limit 3); urinary bladder: 12.3 nTPM (protected, limit 12); rectum: 12 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 6); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 6); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116191,RALGPS2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 57.1898% (minimum 75%, Missing)",0.0742456,0.0557441,-0.178102,0,7,partial,52.1,45.3,26.5,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 12); liver: 28.8 nTPM (vital, limit 6); spleen: 26.5 nTPM (manageable, limit 5); skin: 18.7 nTPM (manageable, limit 5); esophagus: 17.3 nTPM (protected, limit 3); small intestine: 15.9 nTPM (vital, limit 1); thymus: 14.3 nTPM (manageable, limit 5); stomach: 13.5 nTPM (protected, limit 12); colon: 13.4 nTPM (protected, limit 3); urinary bladder: 12.3 nTPM (protected, limit 12); rectum: 12 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 6); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 6); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116191,RALGPS2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 70.7317% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.5744% (minimum 70%, Baseline (adaptation disabled)); retina: 57.1898% (minimum 75%, Baseline (adaptation disabled))",0.0742456,-0.0942559,-0.178102,0,7,partial,52.1,45.3,26.5,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 3); liver: 28.8 nTPM (vital, limit 1); spleen: 26.5 nTPM (manageable, limit 5); skin: 18.7 nTPM (manageable, limit 5); esophagus: 17.3 nTPM (protected, limit 3); small intestine: 15.9 nTPM (vital, limit 1); thymus: 14.3 nTPM (manageable, limit 5); stomach: 13.5 nTPM (protected, limit 3); colon: 13.4 nTPM (protected, limit 3); urinary bladder: 12.3 nTPM (protected, limit 3); rectum: 12 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.9 nTPM (protected, limit 3); thyroid gland: 6.4 nTPM (manageable, limit 5); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 3); salivary gland: 5.3 nTPM (protected, limit 3); adipose tissue: 5.3 nTPM (manageable, limit 5); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116191,RALGPS2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116721,PRAMEF1,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116721,PRAMEF1,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116721,PRAMEF1,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116721,PRAMEF1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116721,PRAMEF1,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_reproductive_selectivity;reviewed_unreliable_ihc,True,True,True,,,,,0,1,unreliable,0.1,0,0,,cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116726,PRAMEF12,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_reproductive_selectivity;reviewed_unreliable_ihc,True,True,True,,,,,0,1,unreliable,0.1,0,0,,cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116726,PRAMEF12,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_reproductive_selectivity;reviewed_unreliable_ihc,True,True,True,,,,,0,1,unreliable,0.1,0,0,,cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116726,PRAMEF12,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_reproductive_selectivity;reviewed_unreliable_ihc,True,True,True,,,,,0,1,unreliable,0.1,0,0,,cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116726,PRAMEF12,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_reproductive_selectivity;reviewed_unreliable_ihc,True,True,True,,,,,0,1,unreliable,0.1,0,0,,cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116726,PRAMEF12,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.8068% (minimum 95%, Missing); adrenal gland: 79.0885% (minimum 99%, Missing); amygdala: 84.5272% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 61.4583% (minimum 99%, Missing); cerebellum: 67.9724% (minimum 99%, Missing); cerebral cortex: 79.9458% (minimum 99%, Missing); choroid plexus: 51.1265% (minimum 99%, Missing); colon: 86.5103% (minimum 97%, Missing); duodenum: 89.6657% (minimum 99%, Missing); esophagus: 92.1875% (minimum 97%, Missing); heart muscle: 84.5272% (minimum 99%, Missing); hippocampal formation: 82.8652% (minimum 99%, Missing); hypothalamus: 77.4278% (minimum 99%, Missing); kidney: 77.8364% (minimum 99%, Missing); liver: 78.8770% (minimum 99%, Missing); lung: 78.8770% (minimum 99%, Missing); lymph node: 84.2857% (minimum 97%, Missing); midbrain: 83.5694% (minimum 99%, Missing); pancreas: 81.7175% (minimum 99%, Missing); parathyroid gland: 72.6601% (minimum 97%, Missing); pituitary gland: 71.6019% (minimum 99%, Missing); rectum: 86.2573% (minimum 97%, Missing); retina: 68.2870% (minimum 99%, Missing); salivary gland: 88.3234% (minimum 97%, Missing); skeletal muscle: 87.0206% (minimum 99%, Missing); skin: 94.5513% (minimum 95%, Missing); small intestine: 88.3234% (minimum 99%, Missing); smooth muscle: 82.1727% (minimum 99%, Missing); spinal cord: 88.5886% (minimum 99%, Missing); spleen: 77.8364% (minimum 95%, Missing); stomach: 81.9444% (minimum 97%, Missing); thymus: 90.2141% (minimum 95%, Missing); thyroid gland: 86.7647% (minimum 95%, Missing); tongue: 91.3313% (minimum 97%, Missing); urinary bladder: 82.8652% (minimum 97%, Missing)",-0.171636,-0.243399,-0.478735,0,80,unavailable,28.2,11.1,8.4,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); hypothalamus: 8.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); kidney: 8.4 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); smooth muscle: 6.4 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 2); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); skeletal muscle: 4.4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116793,PHTF1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 61.4583% (minimum 75%, Missing); cerebellum: 67.9724% (minimum 75%, Missing); choroid plexus: 51.1265% (minimum 75%, Missing); pituitary gland: 71.6019% (minimum 75%, Missing); retina: 68.2870% (minimum 75%, Missing)",0.128364,0.026601,-0.238735,0,80,unavailable,28.2,11.1,8.4,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); hypothalamus: 8.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); kidney: 8.4 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); smooth muscle: 6.4 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 2); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); skeletal muscle: 4.4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116793,PHTF1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 61.4583% (minimum 75%, Missing); cerebellum: 67.9724% (minimum 75%, Missing); choroid plexus: 51.1265% (minimum 75%, Missing); pituitary gland: 71.6019% (minimum 75%, Missing); retina: 68.2870% (minimum 75%, Missing)",0.128364,0.026601,-0.238735,0,80,unavailable,28.2,11.1,8.4,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); hypothalamus: 8.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); kidney: 8.4 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); smooth muscle: 6.4 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 3); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); skeletal muscle: 4.4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116793,PHTF1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 61.4583% (minimum 75%, Missing); cerebellum: 67.9724% (minimum 75%, Missing); choroid plexus: 51.1265% (minimum 75%, Missing); pituitary gland: 71.6019% (minimum 75%, Missing); retina: 68.2870% (minimum 75%, Missing)",0.128364,0.026601,-0.238735,0,80,unavailable,28.2,11.1,8.4,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); hypothalamus: 8.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); kidney: 8.4 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); smooth muscle: 6.4 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 3); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); skeletal muscle: 4.4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116793,PHTF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 61.4583% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.9724% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 51.1265% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 71.6019% (minimum 75%, Baseline (adaptation disabled)); retina: 68.2870% (minimum 75%, Baseline (adaptation disabled))",0.128364,0.026601,-0.238735,0,80,unavailable,28.2,11.1,8.4,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); hypothalamus: 8.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); kidney: 8.4 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); smooth muscle: 6.4 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 3); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); skeletal muscle: 4.4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116793,PHTF1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 66.7870% (minimum 95%, Missing); adrenal gland: 80.0866% (minimum 99%, Missing); amygdala: 83.2084% (minimum 99%, Missing); basal ganglia: 79.3991% (minimum 99%, Missing); bone marrow: 55.5000% (minimum 99%, Missing); cerebellum: 76.4463% (minimum 99%, Missing); cerebral cortex: 77.8401% (minimum 99%, Missing); choroid plexus: 83.5843% (minimum 99%, Missing); colon: 74.1979% (minimum 97%, Missing); duodenum: 72.5490% (minimum 99%, Missing); esophagus: 73.0263% (minimum 97%, Missing); heart muscle: 51.1521% (minimum 99%, Missing); hippocampal formation: 81.4978% (minimum 99%, Missing); hypothalamus: 81.6176% (minimum 99%, Missing); kidney: 70.9719% (minimum 99%, Missing); liver: 53.6750% (minimum 99%, Missing); lung: 67.9315% (minimum 99%, Missing); lymph node: 70.3422% (minimum 97%, Missing); midbrain: 83.4586% (minimum 99%, Missing); pancreas: 72.4543% (minimum 99%, Missing); parathyroid gland: 62.0805% (minimum 97%, Missing); pituitary gland: 81.8584% (minimum 99%, Missing); rectum: 74.1979% (minimum 97%, Missing); retina: 71.4286% (minimum 99%, Missing); salivary gland: 72.0779% (minimum 97%, Missing); skeletal muscle: 89.5161% (minimum 99%, Missing); skin: 63.7931% (minimum 95%, Missing); small intestine: 70.3422% (minimum 99%, Missing); smooth muscle: 72.4543% (minimum 98%, Approved); spinal cord: 79.6270% (minimum 99%, Missing); spleen: 57.1576% (minimum 95%, Missing); stomach: 75.1015% (minimum 97%, Missing); thymus: 68.3498% (minimum 95%, Missing); thyroid gland: 76.8698% (minimum 95%, Missing); tongue: 86.0465% (minimum 97%, Missing); urinary bladder: 63.7199% (minimum 97%, Missing)",-0.378424,-0.349195,-0.478479,0,4,partial,53,33.9,41.6,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); spleen: 41.6 nTPM (manageable, limit 5); parathyroid gland: 33.9 nTPM (protected, limit 2); urinary bladder: 31.6 nTPM (protected, limit 2); skin: 31.5 nTPM (manageable, limit 5); adipose tissue: 27.6 nTPM (manageable, limit 5); lung: 26.2 nTPM (vital, limit 1); thymus: 25.7 nTPM (manageable, limit 5); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 2); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 2); smooth muscle: 21.1 nTPM (vital, limit 2); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 2); colon: 19.3 nTPM (protected, limit 2); rectum: 19.3 nTPM (protected, limit 2); stomach: 18.4 nTPM (protected, limit 2); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116977,LGALS8,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.5000% (minimum 75%, Missing); duodenum: 72.5490% (minimum 75%, Missing); heart muscle: 51.1521% (minimum 75%, Missing); kidney: 70.9719% (minimum 75%, Missing); liver: 53.6750% (minimum 75%, Missing); lung: 67.9315% (minimum 75%, Missing); pancreas: 72.4543% (minimum 75%, Missing); parathyroid gland: 62.0805% (minimum 70%, Missing); retina: 71.4286% (minimum 75%, Missing); skin: 63.7931% (minimum 65%, Missing); small intestine: 70.3422% (minimum 75%, Missing); spleen: 57.1576% (minimum 65%, Missing); urinary bladder: 63.7199% (minimum 70%, Missing)",-0.0784243,-0.0791946,-0.238479,0,4,partial,53,33.9,41.6,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); spleen: 41.6 nTPM (manageable, limit 5); parathyroid gland: 33.9 nTPM (protected, limit 2); urinary bladder: 31.6 nTPM (protected, limit 2); skin: 31.5 nTPM (manageable, limit 5); adipose tissue: 27.6 nTPM (manageable, limit 5); lung: 26.2 nTPM (vital, limit 1); thymus: 25.7 nTPM (manageable, limit 5); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 2); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 2); smooth muscle: 21.1 nTPM (vital, limit 2); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 2); colon: 19.3 nTPM (protected, limit 2); rectum: 19.3 nTPM (protected, limit 2); stomach: 18.4 nTPM (protected, limit 2); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116977,LGALS8,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.5000% (minimum 75%, Missing); duodenum: 72.5490% (minimum 75%, Missing); heart muscle: 51.1521% (minimum 75%, Missing); kidney: 70.9719% (minimum 75%, Missing); liver: 53.6750% (minimum 75%, Missing); lung: 67.9315% (minimum 75%, Missing); pancreas: 72.4543% (minimum 75%, Missing); parathyroid gland: 62.0805% (minimum 70%, Missing); retina: 71.4286% (minimum 75%, Missing); skin: 63.7931% (minimum 65%, Missing); small intestine: 70.3422% (minimum 75%, Missing); spleen: 57.1576% (minimum 65%, Missing); urinary bladder: 63.7199% (minimum 70%, Missing)",-0.0784243,-0.0791946,-0.238479,0,4,partial,53,33.9,41.6,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); spleen: 41.6 nTPM (manageable, limit 5); parathyroid gland: 33.9 nTPM (protected, limit 3); urinary bladder: 31.6 nTPM (protected, limit 3); skin: 31.5 nTPM (manageable, limit 5); adipose tissue: 27.6 nTPM (manageable, limit 5); lung: 26.2 nTPM (vital, limit 1); thymus: 25.7 nTPM (manageable, limit 5); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 3); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 3); smooth muscle: 21.1 nTPM (vital, limit 2); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 3); colon: 19.3 nTPM (protected, limit 3); rectum: 19.3 nTPM (protected, limit 3); stomach: 18.4 nTPM (protected, limit 3); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116977,LGALS8,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.5000% (minimum 75%, Missing); duodenum: 72.5490% (minimum 75%, Missing); heart muscle: 51.1521% (minimum 75%, Missing); kidney: 70.9719% (minimum 75%, Missing); liver: 53.6750% (minimum 75%, Missing); lung: 67.9315% (minimum 75%, Missing); pancreas: 72.4543% (minimum 75%, Missing); parathyroid gland: 62.0805% (minimum 70%, Missing); retina: 71.4286% (minimum 75%, Missing); skin: 63.7931% (minimum 65%, Missing); small intestine: 70.3422% (minimum 75%, Missing); spleen: 57.1576% (minimum 65%, Missing); urinary bladder: 63.7199% (minimum 70%, Missing)",-0.0784243,-0.0791946,-0.238479,0,4,partial,53,33.9,41.6,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); spleen: 41.6 nTPM (manageable, limit 5); parathyroid gland: 33.9 nTPM (protected, limit 3); urinary bladder: 31.6 nTPM (protected, limit 3); skin: 31.5 nTPM (manageable, limit 5); adipose tissue: 27.6 nTPM (manageable, limit 5); lung: 26.2 nTPM (vital, limit 1); thymus: 25.7 nTPM (manageable, limit 5); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 3); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 3); smooth muscle: 21.1 nTPM (vital, limit 2); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 3); colon: 19.3 nTPM (protected, limit 3); rectum: 19.3 nTPM (protected, limit 3); stomach: 18.4 nTPM (protected, limit 3); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116977,LGALS8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.5000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 72.5490% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 51.1521% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.9719% (minimum 75%, Baseline (adaptation disabled)); liver: 53.6750% (minimum 75%, Baseline (adaptation disabled)); lung: 67.9315% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.4543% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.0805% (minimum 70%, Baseline (adaptation disabled)); retina: 71.4286% (minimum 75%, Baseline (adaptation disabled)); skin: 63.7931% (minimum 65%, Baseline (adaptation disabled)); small intestine: 70.3422% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.4543% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.1576% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 63.7199% (minimum 70%, Baseline (adaptation disabled))",-0.0784243,-0.0791946,-0.238479,0,4,partial,53,33.9,41.6,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); spleen: 41.6 nTPM (manageable, limit 5); parathyroid gland: 33.9 nTPM (protected, limit 3); urinary bladder: 31.6 nTPM (protected, limit 3); skin: 31.5 nTPM (manageable, limit 5); adipose tissue: 27.6 nTPM (manageable, limit 5); lung: 26.2 nTPM (vital, limit 1); thymus: 25.7 nTPM (manageable, limit 5); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 3); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 3); smooth muscle: 21.1 nTPM (vital, limit 1); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 3); colon: 19.3 nTPM (protected, limit 3); rectum: 19.3 nTPM (protected, limit 3); stomach: 18.4 nTPM (protected, limit 3); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000116977,LGALS8,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.5714% (minimum 99%, Missing)",0.05,0.00183099,-0.00428571,0,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117148,ACTL8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.271831,0.235714,0,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117148,ACTL8,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.271831,0.235714,0,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117148,ACTL8,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.271831,0.235714,0,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117148,ACTL8,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.271831,0.235714,0,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117148,ACTL8,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.1591% (minimum 99%, Missing); amygdala: 92.5993% (minimum 99%, Missing); basal ganglia: 87.5427% (minimum 99%, Missing); bone marrow: 87.4680% (minimum 99%, Missing); cerebellum: 83.4146% (minimum 99%, Missing); cerebral cortex: 79.1056% (minimum 99%, Missing); choroid plexus: 93.9560% (minimum 99%, Missing); colon: 92.8507% (minimum 97%, Missing); duodenum: 70.9544% (minimum 99%, Missing); esophagus: 94.3015% (minimum 97%, Missing); heart muscle: 91.8532% (minimum 99%, Missing); hippocampal formation: 90.7965% (minimum 99%, Missing); hypothalamus: 95.0000% (minimum 99%, Missing); kidney: 86.5823% (minimum 99%, Missing); liver: 87.9177% (minimum 99%, Missing); lung: 96.5193% (minimum 99%, Missing); lymph node: 94.3015% (minimum 97%, Missing); midbrain: 96.8839% (minimum 99%, Missing); pancreas: 93.6986% (minimum 99%, Missing); parathyroid gland: 92.0179% (minimum 97%, Missing); pituitary gland: 91.6890% (minimum 99%, Missing); rectum: 93.1034% (minimum 97%, Missing); retina: 47.1291% (minimum 99%, Missing); salivary gland: 93.8701% (minimum 97%, Missing); skeletal muscle: 96.7925% (minimum 97%, Supported); skin: 94.2149% (minimum 95%, Missing); small intestine: 79.7203% (minimum 99%, Missing); smooth muscle: 90.8769% (minimum 99%, Missing); spinal cord: 96.8839% (minimum 99%, Missing); stomach: 93.6986% (minimum 97%, Missing); thymus: 89.7638% (minimum 95%, Missing); thyroid gland: 92.7667% (minimum 95%, Missing); urinary bladder: 94.9121% (minimum 97%, Missing)",-0.0523622,-0.0498206,-0.518709,0,10,partial,115.1,8.9,11.7,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 2); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); colon: 7.9 nTPM (protected, limit 2); rectum: 7.6 nTPM (protected, limit 2); stomach: 6.9 nTPM (protected, limit 2); pancreas: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); choroid plexus: 6.6 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 2); esophagus: 6.2 nTPM (protected, limit 2); urinary bladder: 5.5 nTPM (protected, limit 2); hypothalamus: 5.4 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 3); midbrain: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skin 1 / arrector pili muscle cells: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / arrector pili muscle cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117155,SSX2IP,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 70.9544% (minimum 75%, Missing); retina: 47.1291% (minimum 75%, Missing)",0.247638,0.220179,-0.278709,0,10,partial,115.1,8.9,11.7,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 2); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); colon: 7.9 nTPM (protected, limit 2); rectum: 7.6 nTPM (protected, limit 2); stomach: 6.9 nTPM (protected, limit 2); pancreas: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); choroid plexus: 6.6 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 2); esophagus: 6.2 nTPM (protected, limit 2); urinary bladder: 5.5 nTPM (protected, limit 2); hypothalamus: 5.4 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 3); midbrain: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skin 1 / arrector pili muscle cells: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / arrector pili muscle cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117155,SSX2IP,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 70.9544% (minimum 75%, Missing); retina: 47.1291% (minimum 75%, Missing)",0.247638,0.220179,-0.278709,0,10,partial,115.1,8.9,11.7,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 3); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); colon: 7.9 nTPM (protected, limit 3); rectum: 7.6 nTPM (protected, limit 3); stomach: 6.9 nTPM (protected, limit 3); pancreas: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); choroid plexus: 6.6 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 3); esophagus: 6.2 nTPM (protected, limit 3); urinary bladder: 5.5 nTPM (protected, limit 3); hypothalamus: 5.4 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 3); midbrain: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skin 1 / arrector pili muscle cells: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / arrector pili muscle cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117155,SSX2IP,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 70.9544% (minimum 75%, Missing); retina: 47.1291% (minimum 75%, Missing)",0.247638,0.220179,-0.278709,0,10,partial,115.1,8.9,11.7,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 3); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); colon: 7.9 nTPM (protected, limit 3); rectum: 7.6 nTPM (protected, limit 3); stomach: 6.9 nTPM (protected, limit 3); pancreas: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); choroid plexus: 6.6 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 3); esophagus: 6.2 nTPM (protected, limit 3); urinary bladder: 5.5 nTPM (protected, limit 3); hypothalamus: 5.4 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 3); midbrain: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skin 1 / arrector pili muscle cells: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / arrector pili muscle cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117155,SSX2IP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 70.9544% (minimum 75%, Baseline (adaptation disabled)); retina: 47.1291% (minimum 75%, Baseline (adaptation disabled))",0.247638,0.220179,-0.278709,0,10,partial,115.1,8.9,11.7,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 3); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); colon: 7.9 nTPM (protected, limit 3); rectum: 7.6 nTPM (protected, limit 3); stomach: 6.9 nTPM (protected, limit 3); pancreas: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); choroid plexus: 6.6 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 3); esophagus: 6.2 nTPM (protected, limit 3); urinary bladder: 5.5 nTPM (protected, limit 3); hypothalamus: 5.4 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skin 1 / arrector pili muscle cells: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / arrector pili muscle cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117155,SSX2IP,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 95.2381% (minimum 99%, Missing); basal ganglia: 95.2381% (minimum 99%, Missing); bone marrow: 54.0541% (minimum 99%, Missing); cerebral cortex: 71.4286% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); colon: 86.9565% (minimum 97%, Missing); duodenum: 86.9565% (minimum 99%, Missing); esophagus: 80.0000% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 95.2381% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 76.9231% (minimum 99%, Missing); lymph node: 90.9091% (minimum 97%, Missing); midbrain: 95.2381% (minimum 99%, Missing); pancreas: 74.0741% (minimum 99%, Missing); parathyroid gland: 86.9565% (minimum 97%, Missing); rectum: 86.9565% (minimum 97%, Missing); retina: 57.1429% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 76.9231% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 90.9091% (minimum 99%, Missing); smooth muscle: 74.0741% (minimum 99%, Missing); spinal cord: 95.2381% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thyroid gland: 68.9655% (minimum 95%, Missing); tongue: 86.9565% (minimum 97%, Missing); urinary bladder: 90.9091% (minimum 97%, Missing)",-0.260345,-0.17,-0.449459,0,80,unavailable,1.7,0.5,0.9,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117400,MPL,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 54.0541% (minimum 75%, Missing); cerebral cortex: 71.4286% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); pancreas: 74.0741% (minimum 75%, Missing); retina: 57.1429% (minimum 75%, Missing); smooth muscle: 74.0741% (minimum 75%, Missing)",0.0396552,0.1,-0.209459,0,80,unavailable,1.7,0.5,0.9,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117400,MPL,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 54.0541% (minimum 75%, Missing); cerebral cortex: 71.4286% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); pancreas: 74.0741% (minimum 75%, Missing); retina: 57.1429% (minimum 75%, Missing); smooth muscle: 74.0741% (minimum 75%, Missing)",0.0396552,0.1,-0.209459,0,80,unavailable,1.7,0.5,0.9,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117400,MPL,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 54.0541% (minimum 75%, Missing); cerebral cortex: 71.4286% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); pancreas: 74.0741% (minimum 75%, Missing); retina: 57.1429% (minimum 75%, Missing); smooth muscle: 74.0741% (minimum 75%, Missing)",0.0396552,0.1,-0.209459,0,80,unavailable,1.7,0.5,0.9,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117400,MPL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 54.0541% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 71.4286% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 74.0741% (minimum 75%, Baseline (adaptation disabled)); retina: 57.1429% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 74.0741% (minimum 75%, Baseline (adaptation disabled))",0.0396552,0.1,-0.209459,0,80,unavailable,1.7,0.5,0.9,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117400,MPL,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2949% (minimum 95%, Missing); adrenal gland: 69.6658% (minimum 99%, Missing); amygdala: 72.0745% (minimum 99%, Missing); basal ganglia: 73.8420% (minimum 99%, Missing); bone marrow: 97.4820% (minimum 99%, Missing); cerebellum: 37.4827% (minimum 99%, Missing); cerebral cortex: 70.2073% (minimum 99%, Missing); choroid plexus: 66.2592% (minimum 99%, Missing); colon: 79.0087% (minimum 97%, Missing); duodenum: 89.7351% (minimum 99%, Missing); esophagus: 79.7059% (minimum 95%, Approved); heart muscle: 44.2088% (minimum 98%, Approved); hippocampal formation: 76.1236% (minimum 99%, Missing); hypothalamus: 69.6658% (minimum 99%, Missing); kidney: 63.3178% (minimum 99%, Missing); liver: 87.4194% (minimum 99%, Missing); lung: 60.0887% (minimum 99%, Missing); lymph node: 81.6265% (minimum 97%, Missing); midbrain: 70.0258% (minimum 99%, Missing); pancreas: 85.7595% (minimum 99%, Missing); parathyroid gland: 69.8454% (minimum 97%, Missing); pituitary gland: 76.5537% (minimum 99%, Missing); rectum: 85.2201% (minimum 97%, Missing); retina: 61.0360% (minimum 99%, Missing); salivary gland: 68.9567% (minimum 97%, Missing); skeletal muscle: 70.0258% (minimum 98%, Approved); skin: 81.6265% (minimum 95%, Missing); small intestine: 76.5537% (minimum 99%, Missing); smooth muscle: 70.9424% (minimum 98%, Approved); spinal cord: 75.4875% (minimum 99%, Missing); spleen: 71.3158% (minimum 95%, Missing); stomach: 73.8420% (minimum 97%, Missing); thymus: 72.0745% (minimum 95%, Missing); thyroid gland: 66.2592% (minimum 95%, Missing); tongue: 60.4911% (minimum 97%, Missing); urinary bladder: 65.4589% (minimum 97%, Missing)",-0.477051,-0.365089,-0.615173,0,4,partial,45.2,17.7,30.2,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 2); adipose tissue: 30.2 nTPM (manageable, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 2); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 2); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 2); skeletal muscle: 11.6 nTPM (vital, limit 2); midbrain: 11.6 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 2); spleen: 10.9 nTPM (manageable, limit 5); amygdala: 10.5 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 2); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 2); esophagus: 6.9 nTPM (protected, limit 4); lymph node: 6.1 nTPM (protected, limit 2); skin: 6.1 nTPM (manageable, limit 5); rectum: 4.7 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117461,PIK3R3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2949% (minimum 65%, Missing); adrenal gland: 69.6658% (minimum 75%, Missing); amygdala: 72.0745% (minimum 75%, Missing); basal ganglia: 73.8420% (minimum 75%, Missing); cerebellum: 37.4827% (minimum 75%, Missing); cerebral cortex: 70.2073% (minimum 75%, Missing); choroid plexus: 66.2592% (minimum 75%, Missing); heart muscle: 44.2088% (minimum 70%, Approved); hypothalamus: 69.6658% (minimum 75%, Missing); kidney: 63.3178% (minimum 75%, Missing); lung: 60.0887% (minimum 75%, Missing); midbrain: 70.0258% (minimum 75%, Missing); parathyroid gland: 69.8454% (minimum 70%, Missing); retina: 61.0360% (minimum 75%, Missing); salivary gland: 68.9567% (minimum 70%, Missing); tongue: 60.4911% (minimum 70%, Missing); urinary bladder: 65.4589% (minimum 70%, Missing)",-0.177051,-0.0950893,-0.375173,0,4,partial,45.2,17.7,30.2,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 2); adipose tissue: 30.2 nTPM (manageable, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 2); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 2); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 2); skeletal muscle: 11.6 nTPM (vital, limit 2); midbrain: 11.6 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 2); spleen: 10.9 nTPM (manageable, limit 5); amygdala: 10.5 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 2); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 2); esophagus: 6.9 nTPM (protected, limit 4); lymph node: 6.1 nTPM (protected, limit 2); skin: 6.1 nTPM (manageable, limit 5); rectum: 4.7 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117461,PIK3R3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2949% (minimum 65%, Missing); adrenal gland: 69.6658% (minimum 75%, Missing); amygdala: 72.0745% (minimum 75%, Missing); basal ganglia: 73.8420% (minimum 75%, Missing); cerebellum: 37.4827% (minimum 75%, Missing); cerebral cortex: 70.2073% (minimum 75%, Missing); choroid plexus: 66.2592% (minimum 75%, Missing); heart muscle: 44.2088% (minimum 70%, Approved); hypothalamus: 69.6658% (minimum 75%, Missing); kidney: 63.3178% (minimum 75%, Missing); lung: 60.0887% (minimum 75%, Missing); midbrain: 70.0258% (minimum 75%, Missing); parathyroid gland: 69.8454% (minimum 70%, Missing); retina: 61.0360% (minimum 75%, Missing); salivary gland: 68.9567% (minimum 70%, Missing); tongue: 60.4911% (minimum 70%, Missing); urinary bladder: 65.4589% (minimum 70%, Missing)",-0.177051,-0.0950893,-0.375173,0,4,partial,45.2,17.7,30.2,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 2); adipose tissue: 30.2 nTPM (manageable, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 3); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 3); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 3); skeletal muscle: 11.6 nTPM (vital, limit 2); midbrain: 11.6 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 2); spleen: 10.9 nTPM (manageable, limit 5); amygdala: 10.5 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 3); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 3); esophagus: 6.9 nTPM (protected, limit 4); lymph node: 6.1 nTPM (protected, limit 3); skin: 6.1 nTPM (manageable, limit 5); rectum: 4.7 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117461,PIK3R3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2949% (minimum 65%, Missing); adrenal gland: 69.6658% (minimum 75%, Missing); amygdala: 72.0745% (minimum 75%, Missing); basal ganglia: 73.8420% (minimum 75%, Missing); cerebellum: 37.4827% (minimum 75%, Missing); cerebral cortex: 70.2073% (minimum 75%, Missing); choroid plexus: 66.2592% (minimum 75%, Missing); heart muscle: 44.2088% (minimum 70%, Approved); hypothalamus: 69.6658% (minimum 75%, Missing); kidney: 63.3178% (minimum 75%, Missing); lung: 60.0887% (minimum 75%, Missing); midbrain: 70.0258% (minimum 75%, Missing); parathyroid gland: 69.8454% (minimum 70%, Missing); retina: 61.0360% (minimum 75%, Missing); salivary gland: 68.9567% (minimum 70%, Missing); tongue: 60.4911% (minimum 70%, Missing); urinary bladder: 65.4589% (minimum 70%, Missing)",-0.177051,-0.0950893,-0.375173,0,4,partial,45.2,17.7,30.2,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 2); adipose tissue: 30.2 nTPM (manageable, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 3); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 3); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 3); skeletal muscle: 11.6 nTPM (vital, limit 2); midbrain: 11.6 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 2); spleen: 10.9 nTPM (manageable, limit 5); amygdala: 10.5 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 3); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 3); esophagus: 6.9 nTPM (protected, limit 4); lymph node: 6.1 nTPM (protected, limit 3); skin: 6.1 nTPM (manageable, limit 5); rectum: 4.7 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117461,PIK3R3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2949% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 69.6658% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.0745% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.8420% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 37.4827% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.2073% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.2592% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 44.2088% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.6658% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.3178% (minimum 75%, Baseline (adaptation disabled)); lung: 60.0887% (minimum 75%, Baseline (adaptation disabled)); midbrain: 70.0258% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.8454% (minimum 70%, Baseline (adaptation disabled)); retina: 61.0360% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.9567% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 70.0258% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.9424% (minimum 75%, Baseline (adaptation disabled)); tongue: 60.4911% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.4589% (minimum 70%, Baseline (adaptation disabled))",-0.177051,-0.0950893,-0.375173,0,4,partial,45.2,17.7,30.2,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 1); adipose tissue: 30.2 nTPM (manageable, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 3); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 3); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 3); skeletal muscle: 11.6 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); amygdala: 10.5 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 3); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 3); esophagus: 6.9 nTPM (protected, limit 3); lymph node: 6.1 nTPM (protected, limit 3); skin: 6.1 nTPM (manageable, limit 5); rectum: 4.7 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117461,PIK3R3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.2479% (minimum 80%, Supported); adrenal gland: 72.8051% (minimum 99%, Missing); amygdala: 81.7308% (minimum 99%, Missing); basal ganglia: 83.1296% (minimum 99%, Missing); bone marrow: 57.5296% (minimum 99%, Missing); cerebellum: 83.9506% (minimum 99%, Missing); cerebral cortex: 77.4487% (minimum 99%, Missing); choroid plexus: 80.9524% (minimum 99%, Missing); colon: 71.7300% (minimum 97%, Missing); duodenum: 73.9130% (minimum 99%, Missing); esophagus: 52.0674% (minimum 97%, Missing); heart muscle: 68.8259% (minimum 99%, Missing); hippocampal formation: 81.9277% (minimum 99%, Missing); hypothalamus: 82.3245% (minimum 99%, Missing); kidney: 67.4603% (minimum 99%, Missing); liver: 70.1031% (minimum 99%, Missing); lung: 73.1183% (minimum 99%, Missing); lymph node: 74.7253% (minimum 97%, Missing); midbrain: 80.9524% (minimum 99%, Missing); pancreas: 78.7037% (minimum 99%, Missing); parathyroid gland: 69.9588% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 69.3878% (minimum 97%, Missing); retina: 60.6061% (minimum 99%, Missing); salivary gland: 73.4341% (minimum 97%, Missing); skeletal muscle: 75.8929% (minimum 99%, Missing); skin: 66.1479% (minimum 95%, Missing); small intestine: 73.4341% (minimum 99%, Missing); smooth muscle: 66.4062% (minimum 99%, Missing); spinal cord: 78.1609% (minimum 99%, Missing); spleen: 73.7527% (minimum 95%, Missing); stomach: 72.8051% (minimum 97%, Missing); thymus: 71.7300% (minimum 95%, Missing); thyroid gland: 65.2591% (minimum 95%, Missing); tongue: 76.2332% (minimum 97%, Missing); urinary bladder: 68.0000% (minimum 97%, Missing)",-0.297409,-0.449326,-0.414704,0,5,partial,25.1,31.3,18.1,"esophagus: 31.3 nTPM (protected, limit 2); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); skin: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 2); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 2); parathyroid gland: 14.6 nTPM (protected, limit 2); liver: 14.5 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); colon: 13.4 nTPM (protected, limit 2); stomach: 12.7 nTPM (protected, limit 2); adrenal gland: 12.7 nTPM (vital, limit 1); lung: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 2); small intestine: 12.3 nTPM (vital, limit 1); spleen: 12.1 nTPM (manageable, limit 5); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 2); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 2); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117475,BLZF1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.8051% (minimum 75%, Missing); bone marrow: 57.5296% (minimum 75%, Missing); duodenum: 73.9130% (minimum 75%, Missing); esophagus: 52.0674% (minimum 70%, Missing); heart muscle: 68.8259% (minimum 75%, Missing); kidney: 67.4603% (minimum 75%, Missing); liver: 70.1031% (minimum 75%, Missing); lung: 73.1183% (minimum 75%, Missing); parathyroid gland: 69.9588% (minimum 70%, Missing); rectum: 69.3878% (minimum 70%, Missing); retina: 60.6061% (minimum 75%, Missing); small intestine: 73.4341% (minimum 75%, Missing); smooth muscle: 66.4062% (minimum 75%, Missing); urinary bladder: 68.0000% (minimum 70%, Missing)",0.00259117,-0.179326,-0.174704,0,5,partial,25.1,31.3,18.1,"esophagus: 31.3 nTPM (protected, limit 2); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); skin: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 2); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 2); parathyroid gland: 14.6 nTPM (protected, limit 2); liver: 14.5 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); colon: 13.4 nTPM (protected, limit 2); stomach: 12.7 nTPM (protected, limit 2); adrenal gland: 12.7 nTPM (vital, limit 1); lung: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 2); small intestine: 12.3 nTPM (vital, limit 1); spleen: 12.1 nTPM (manageable, limit 5); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 2); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 2); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117475,BLZF1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.8051% (minimum 75%, Missing); bone marrow: 57.5296% (minimum 75%, Missing); duodenum: 73.9130% (minimum 75%, Missing); esophagus: 52.0674% (minimum 70%, Missing); heart muscle: 68.8259% (minimum 75%, Missing); kidney: 67.4603% (minimum 75%, Missing); liver: 70.1031% (minimum 75%, Missing); lung: 73.1183% (minimum 75%, Missing); parathyroid gland: 69.9588% (minimum 70%, Missing); rectum: 69.3878% (minimum 70%, Missing); retina: 60.6061% (minimum 75%, Missing); small intestine: 73.4341% (minimum 75%, Missing); smooth muscle: 66.4062% (minimum 75%, Missing); urinary bladder: 68.0000% (minimum 70%, Missing)",0.00259117,-0.179326,-0.174704,0,5,partial,25.1,31.3,18.1,"esophagus: 31.3 nTPM (protected, limit 3); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); skin: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 3); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 3); parathyroid gland: 14.6 nTPM (protected, limit 3); liver: 14.5 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); colon: 13.4 nTPM (protected, limit 3); stomach: 12.7 nTPM (protected, limit 3); adrenal gland: 12.7 nTPM (vital, limit 1); lung: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 3); small intestine: 12.3 nTPM (vital, limit 1); spleen: 12.1 nTPM (manageable, limit 5); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 3); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 3); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117475,BLZF1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.8051% (minimum 75%, Missing); bone marrow: 57.5296% (minimum 75%, Missing); duodenum: 73.9130% (minimum 75%, Missing); esophagus: 52.0674% (minimum 70%, Missing); heart muscle: 68.8259% (minimum 75%, Missing); kidney: 67.4603% (minimum 75%, Missing); liver: 70.1031% (minimum 75%, Missing); lung: 73.1183% (minimum 75%, Missing); parathyroid gland: 69.9588% (minimum 70%, Missing); rectum: 69.3878% (minimum 70%, Missing); retina: 60.6061% (minimum 75%, Missing); small intestine: 73.4341% (minimum 75%, Missing); smooth muscle: 66.4062% (minimum 75%, Missing); urinary bladder: 68.0000% (minimum 70%, Missing)",0.00259117,-0.179326,-0.174704,0,5,partial,25.1,31.3,18.1,"esophagus: 31.3 nTPM (protected, limit 3); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); skin: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 3); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 3); parathyroid gland: 14.6 nTPM (protected, limit 3); liver: 14.5 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); colon: 13.4 nTPM (protected, limit 3); stomach: 12.7 nTPM (protected, limit 3); adrenal gland: 12.7 nTPM (vital, limit 1); lung: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 3); small intestine: 12.3 nTPM (vital, limit 1); spleen: 12.1 nTPM (manageable, limit 5); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 3); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 3); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117475,BLZF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.8051% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 57.5296% (minimum 75%, Baseline (adaptation disabled)); duodenum: 73.9130% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.0674% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.8259% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.4603% (minimum 75%, Baseline (adaptation disabled)); liver: 70.1031% (minimum 75%, Baseline (adaptation disabled)); lung: 73.1183% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.9588% (minimum 70%, Baseline (adaptation disabled)); rectum: 69.3878% (minimum 70%, Baseline (adaptation disabled)); retina: 60.6061% (minimum 75%, Baseline (adaptation disabled)); small intestine: 73.4341% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.4062% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 68.0000% (minimum 70%, Baseline (adaptation disabled))",0.00259117,-0.179326,-0.174704,0,5,partial,25.1,31.3,18.1,"esophagus: 31.3 nTPM (protected, limit 3); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); skin: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 3); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 3); parathyroid gland: 14.6 nTPM (protected, limit 3); liver: 14.5 nTPM (vital, limit 1); adipose tissue: 14.4 nTPM (manageable, limit 5); colon: 13.4 nTPM (protected, limit 3); thymus: 13.4 nTPM (manageable, limit 5); adrenal gland: 12.7 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 3); lung: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 3); small intestine: 12.3 nTPM (vital, limit 1); spleen: 12.1 nTPM (manageable, limit 5); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 3); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 3); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117475,BLZF1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.7266% (minimum 95%, Enhanced); amygdala: 79.1925% (minimum 99%, Missing); basal ganglia: 76.1194% (minimum 99%, Missing); cerebellum: 81.2102% (minimum 95%, Enhanced); cerebral cortex: 75.8929% (minimum 95%, Enhanced); choroid plexus: 44.7368% (minimum 99%, Missing); heart muscle: 93.4066% (minimum 95%, Enhanced); hippocampal formation: 77.5076% (minimum 99%, Missing); hypothalamus: 69.6721% (minimum 99%, Missing); kidney: 81.9936% (minimum 95%, Enhanced); lung: 93.7500% (minimum 95%, Enhanced); midbrain: 80.9524% (minimum 99%, Missing); pancreas: 87.6289% (minimum 95%, Enhanced); parathyroid gland: 69.4823% (minimum 80%, Enhanced); pituitary gland: 59.1647% (minimum 99%, Missing); retina: 39.7196% (minimum 99%, Missing); smooth muscle: 93.4066% (minimum 95%, Enhanced); spinal cord: 84.4371% (minimum 99%, Missing)",0.0383721,-0.105177,-0.592804,0,6,partial,38.7,11.2,0.5,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 6); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117477,CCDC181,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 44.7368% (minimum 75%, Missing); hypothalamus: 69.6721% (minimum 75%, Missing); pituitary gland: 59.1647% (minimum 75%, Missing); retina: 39.7196% (minimum 75%, Missing)",0.338372,0.144823,-0.352804,0,6,partial,38.7,11.2,0.5,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 6); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117477,CCDC181,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 44.7368% (minimum 75%, Missing); hypothalamus: 69.6721% (minimum 75%, Missing); pituitary gland: 59.1647% (minimum 75%, Missing); retina: 39.7196% (minimum 75%, Missing)",0.338372,0.144823,-0.352804,0,6,partial,38.7,11.2,0.5,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 6); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117477,CCDC181,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 44.7368% (minimum 75%, Missing); hypothalamus: 69.6721% (minimum 75%, Missing); pituitary gland: 59.1647% (minimum 75%, Missing); retina: 39.7196% (minimum 75%, Missing)",0.338372,0.144823,-0.352804,0,6,partial,38.7,11.2,0.5,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 6); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117477,CCDC181,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 44.7368% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.6721% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.4823% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 59.1647% (minimum 75%, Baseline (adaptation disabled)); retina: 39.7196% (minimum 75%, Baseline (adaptation disabled))",0.330769,-0.00517711,-0.352804,0,6,partial,38.7,11.2,0.5,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); parathyroid gland: 11.2 nTPM (protected, limit 3); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117477,CCDC181,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6622% (minimum 95%, Uncertain); adrenal gland: 74.9186% (minimum 99%, Uncertain); amygdala: 57.6441% (minimum 99%, Missing); basal ganglia: 60.5263% (minimum 99%, Missing); bone marrow: 66.8605% (minimum 99%, Uncertain); cerebellum: 54.7619% (minimum 99%, Uncertain); cerebral cortex: 59.1260% (minimum 99%, Uncertain); choroid plexus: 90.9091% (minimum 99%, Missing); colon: 41.5913% (minimum 97%, Uncertain); duodenum: 85.8209% (minimum 99%, Uncertain); esophagus: 74.9186% (minimum 97%, Missing); heart muscle: 75.1634% (minimum 99%, Uncertain); hippocampal formation: 54.8926% (minimum 99%, Missing); hypothalamus: 55.2885% (minimum 99%, Missing); kidney: 68.8623% (minimum 99%, Uncertain); liver: 75.9076% (minimum 99%, Uncertain); lung: 73.2484% (minimum 99%, Uncertain); lymph node: 79.8611% (minimum 97%, Uncertain); midbrain: 55.2885% (minimum 99%, Missing); pancreas: 76.9231% (minimum 99%, Missing); parathyroid gland: 90.9091% (minimum 97%, Uncertain); pituitary gland: 67.4487% (minimum 99%, Missing); rectum: 78.4983% (minimum 97%, Uncertain); retina: 63.7119% (minimum 99%, Missing); salivary gland: 74.1935% (minimum 97%, Uncertain); skeletal muscle: 67.8466% (minimum 99%, Uncertain); skin: 73.4824% (minimum 95%, Uncertain); small intestine: 64.7887% (minimum 99%, Uncertain); smooth muscle: 64.6067% (minimum 99%, Uncertain); spinal cord: 53.1178% (minimum 99%, Missing); spleen: 67.2515% (minimum 95%, Uncertain); stomach: 66.0920% (minimum 97%, Uncertain); thymus: 69.2771% (minimum 95%, Missing); thyroid gland: 66.4740% (minimum 95%, Uncertain); tongue: 72.7848% (minimum 97%, Missing); urinary bladder: 57.6441% (minimum 97%, Uncertain)",-0.333378,-0.554087,-0.458822,0,1,partial,20.3,32.3,14.3,"colon: 32.3 nTPM (protected, limit 2); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 2); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 2); thyroid gland: 11.6 nTPM (manageable, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); spleen: 11.2 nTPM (manageable, limit 5); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); tongue: 8.6 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); salivary gland: 8 nTPM (protected, limit 2); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 2); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); lymph node: 5.8 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117569,PTBP2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6622% (minimum 65%, Uncertain); adrenal gland: 74.9186% (minimum 75%, Uncertain); amygdala: 57.6441% (minimum 75%, Missing); basal ganglia: 60.5263% (minimum 75%, Missing); bone marrow: 66.8605% (minimum 75%, Uncertain); cerebellum: 54.7619% (minimum 75%, Uncertain); cerebral cortex: 59.1260% (minimum 75%, Uncertain); colon: 41.5913% (minimum 70%, Uncertain); hippocampal formation: 54.8926% (minimum 75%, Missing); hypothalamus: 55.2885% (minimum 75%, Missing); kidney: 68.8623% (minimum 75%, Uncertain); lung: 73.2484% (minimum 75%, Uncertain); midbrain: 55.2885% (minimum 75%, Missing); pituitary gland: 67.4487% (minimum 75%, Missing); retina: 63.7119% (minimum 75%, Missing); skeletal muscle: 67.8466% (minimum 75%, Uncertain); small intestine: 64.7887% (minimum 75%, Uncertain); smooth muscle: 64.6067% (minimum 75%, Uncertain); spinal cord: 53.1178% (minimum 75%, Missing); stomach: 66.0920% (minimum 70%, Uncertain); urinary bladder: 57.6441% (minimum 70%, Uncertain)",-0.033378,-0.284087,-0.218822,0,1,partial,20.3,32.3,14.3,"colon: 32.3 nTPM (protected, limit 2); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 2); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 2); thyroid gland: 11.6 nTPM (manageable, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); spleen: 11.2 nTPM (manageable, limit 5); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); tongue: 8.6 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); salivary gland: 8 nTPM (protected, limit 2); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 2); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); lymph node: 5.8 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117569,PTBP2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6622% (minimum 65%, Uncertain); adrenal gland: 74.9186% (minimum 75%, Uncertain); amygdala: 57.6441% (minimum 75%, Missing); basal ganglia: 60.5263% (minimum 75%, Missing); bone marrow: 66.8605% (minimum 75%, Uncertain); cerebellum: 54.7619% (minimum 75%, Uncertain); cerebral cortex: 59.1260% (minimum 75%, Uncertain); colon: 41.5913% (minimum 70%, Uncertain); hippocampal formation: 54.8926% (minimum 75%, Missing); hypothalamus: 55.2885% (minimum 75%, Missing); kidney: 68.8623% (minimum 75%, Uncertain); lung: 73.2484% (minimum 75%, Uncertain); midbrain: 55.2885% (minimum 75%, Missing); pituitary gland: 67.4487% (minimum 75%, Missing); retina: 63.7119% (minimum 75%, Missing); skeletal muscle: 67.8466% (minimum 75%, Uncertain); small intestine: 64.7887% (minimum 75%, Uncertain); smooth muscle: 64.6067% (minimum 75%, Uncertain); spinal cord: 53.1178% (minimum 75%, Missing); stomach: 66.0920% (minimum 70%, Uncertain); urinary bladder: 57.6441% (minimum 70%, Uncertain)",-0.033378,-0.284087,-0.218822,0,1,partial,20.3,32.3,14.3,"colon: 32.3 nTPM (protected, limit 3); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 3); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 3); thyroid gland: 11.6 nTPM (manageable, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); spleen: 11.2 nTPM (manageable, limit 5); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); tongue: 8.6 nTPM (protected, limit 3); lung: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); salivary gland: 8 nTPM (protected, limit 3); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 3); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); lymph node: 5.8 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117569,PTBP2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6622% (minimum 65%, Uncertain); adrenal gland: 74.9186% (minimum 75%, Uncertain); amygdala: 57.6441% (minimum 75%, Missing); basal ganglia: 60.5263% (minimum 75%, Missing); bone marrow: 66.8605% (minimum 75%, Uncertain); cerebellum: 54.7619% (minimum 75%, Uncertain); cerebral cortex: 59.1260% (minimum 75%, Uncertain); colon: 41.5913% (minimum 70%, Uncertain); hippocampal formation: 54.8926% (minimum 75%, Missing); hypothalamus: 55.2885% (minimum 75%, Missing); kidney: 68.8623% (minimum 75%, Uncertain); lung: 73.2484% (minimum 75%, Uncertain); midbrain: 55.2885% (minimum 75%, Missing); pituitary gland: 67.4487% (minimum 75%, Missing); retina: 63.7119% (minimum 75%, Missing); skeletal muscle: 67.8466% (minimum 75%, Uncertain); small intestine: 64.7887% (minimum 75%, Uncertain); smooth muscle: 64.6067% (minimum 75%, Uncertain); spinal cord: 53.1178% (minimum 75%, Missing); stomach: 66.0920% (minimum 70%, Uncertain); urinary bladder: 57.6441% (minimum 70%, Uncertain)",-0.033378,-0.284087,-0.218822,0,1,partial,20.3,32.3,14.3,"colon: 32.3 nTPM (protected, limit 3); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 3); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 3); thyroid gland: 11.6 nTPM (manageable, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); spleen: 11.2 nTPM (manageable, limit 5); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); tongue: 8.6 nTPM (protected, limit 3); lung: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); salivary gland: 8 nTPM (protected, limit 3); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 3); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); lymph node: 5.8 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117569,PTBP2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6622% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 74.9186% (minimum 75%, Baseline (adaptation disabled)); amygdala: 57.6441% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.5263% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.8605% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.7619% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 59.1260% (minimum 75%, Baseline (adaptation disabled)); colon: 41.5913% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 54.8926% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.2885% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.8623% (minimum 75%, Baseline (adaptation disabled)); lung: 73.2484% (minimum 75%, Baseline (adaptation disabled)); midbrain: 55.2885% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 67.4487% (minimum 75%, Baseline (adaptation disabled)); retina: 63.7119% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 67.8466% (minimum 75%, Baseline (adaptation disabled)); small intestine: 64.7887% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.6067% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.1178% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.0920% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.6441% (minimum 70%, Baseline (adaptation disabled))",-0.033378,-0.284087,-0.218822,0,1,partial,20.3,32.3,14.3,"colon: 32.3 nTPM (protected, limit 3); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 3); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 3); thyroid gland: 11.6 nTPM (manageable, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); spleen: 11.2 nTPM (manageable, limit 5); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); tongue: 8.6 nTPM (protected, limit 3); lung: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); salivary gland: 8 nTPM (protected, limit 3); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 3); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); lymph node: 5.8 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117569,PTBP2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.5510% (minimum 90%, Approved); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 82.6087% (minimum 99%, Missing); basal ganglia: 80.8511% (minimum 99%, Missing); bone marrow: 88.3721% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 80.8511% (minimum 99%, Missing); choroid plexus: 88.3721% (minimum 99%, Missing); colon: 79.1667% (minimum 97%, Missing); duodenum: 92.6829% (minimum 99%, Missing); esophagus: 86.3636% (minimum 97%, Missing); heart muscle: 79.1667% (minimum 99%, Missing); hippocampal formation: 80.8511% (minimum 99%, Missing); hypothalamus: 80.8511% (minimum 99%, Missing); kidney: 82.6087% (minimum 99%, Missing); liver: 80.8511% (minimum 99%, Missing); lung: 76.0000% (minimum 99%, Missing); lymph node: 63.3333% (minimum 97%, Missing); midbrain: 80.8511% (minimum 99%, Missing); pancreas: 77.5510% (minimum 99%, Missing); parathyroid gland: 88.3721% (minimum 95%, Approved); pituitary gland: 71.6981% (minimum 99%, Missing); rectum: 76.0000% (minimum 97%, Missing); retina: 74.5098% (minimum 99%, Missing); salivary gland: 90.4762% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); skin: 92.6829% (minimum 95%, Missing); small intestine: 82.6087% (minimum 99%, Missing); smooth muscle: 82.6087% (minimum 99%, Missing); spinal cord: 80.8511% (minimum 99%, Missing); spleen: 70.3704% (minimum 90%, Approved); stomach: 84.4444% (minimum 97%, Missing); thymus: 51.3514% (minimum 95%, Missing); thyroid gland: 90.4762% (minimum 95%, Missing); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 73.0769% (minimum 97%, Missing)",-0.436486,-0.336667,-0.323333,0,5,partial,1.9,2.2,3.6,"lymph node: 2.2 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117586,TNFSF4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); lymph node: 63.3333% (minimum 70%, Missing); pituitary gland: 71.6981% (minimum 75%, Missing); retina: 74.5098% (minimum 75%, Missing); thymus: 51.3514% (minimum 65%, Missing)",-0.136486,-0.0666667,-0.0833333,0,5,partial,1.9,2.2,3.6,"lymph node: 2.2 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117586,TNFSF4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); lymph node: 63.3333% (minimum 70%, Missing); pituitary gland: 71.6981% (minimum 75%, Missing); retina: 74.5098% (minimum 75%, Missing); thymus: 51.3514% (minimum 65%, Missing)",-0.136486,-0.0666667,-0.0833333,0,5,partial,1.9,2.2,3.6,"adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117586,TNFSF4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); lymph node: 63.3333% (minimum 70%, Missing); pituitary gland: 71.6981% (minimum 75%, Missing); retina: 74.5098% (minimum 75%, Missing); thymus: 51.3514% (minimum 65%, Missing)",-0.136486,-0.0666667,-0.0833333,0,5,partial,1.9,2.2,3.6,"adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117586,TNFSF4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lymph node: 63.3333% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.6981% (minimum 75%, Baseline (adaptation disabled)); retina: 74.5098% (minimum 75%, Baseline (adaptation disabled)); thymus: 51.3514% (minimum 65%, Baseline (adaptation disabled))",-0.136486,-0.0666667,-0.0833333,0,5,partial,1.9,2.2,3.6,"adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117586,TNFSF4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 78.8392% (minimum 95%, Enhanced); duodenum: 90.0552% (minimum 95%, Enhanced); lymph node: 88.1081% (minimum 97%, Missing); rectum: 89.8072% (minimum 97%, Missing); retina: 97.8979% (minimum 99%, Missing); small intestine: 90.6815% (minimum 99%, Missing); thymus: 77.7116% (minimum 95%, Missing)",-0.172884,-0.0889189,-0.161608,0,2,partial,17.5,8.8,18.7,"thymus: 18.7 nTPM (manageable, limit 5); bone marrow: 17.5 nTPM (vital, limit 6); lymph node: 8.8 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 6); small intestine: 6.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117650,NEK2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.127116,0.181081,0.156815,0,2,partial,17.5,8.8,18.7,"thymus: 18.7 nTPM (manageable, limit 5); bone marrow: 17.5 nTPM (vital, limit 6); lymph node: 8.8 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 6); small intestine: 6.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117650,NEK2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.127116,0.181081,0.156815,0,2,partial,17.5,8.8,18.7,"thymus: 18.7 nTPM (manageable, limit 5); bone marrow: 17.5 nTPM (vital, limit 6); lymph node: 8.8 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 6); small intestine: 6.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117650,NEK2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.127116,0.181081,0.156815,0,2,partial,17.5,8.8,18.7,"thymus: 18.7 nTPM (manageable, limit 5); bone marrow: 17.5 nTPM (vital, limit 6); lymph node: 8.8 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 6); small intestine: 6.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117650,NEK2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.127116,0.181081,0.0383918,0,2,partial,17.5,8.8,18.7,"thymus: 18.7 nTPM (manageable, limit 5); bone marrow: 17.5 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); smooth muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117650,NEK2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6430% (minimum 90%, Approved); adrenal gland: 58.2500% (minimum 99%, Missing); amygdala: 75.6494% (minimum 99%, Missing); basal ganglia: 70.4992% (minimum 99%, Missing); bone marrow: 61.3966% (minimum 98%, Approved); cerebellum: 67.3410% (minimum 99%, Missing); cerebral cortex: 70.9285% (minimum 99%, Missing); choroid plexus: 74.0859% (minimum 99%, Missing); colon: 55.6750% (minimum 97%, Missing); duodenum: 69.3452% (minimum 99%, Missing); esophagus: 54.2491% (minimum 95%, Approved); heart muscle: 58.1047% (minimum 98%, Approved); hippocampal formation: 72.4728% (minimum 99%, Missing); hypothalamus: 71.4724% (minimum 99%, Missing); kidney: 64.9930% (minimum 99%, Missing); liver: 67.6343% (minimum 99%, Missing); lung: 59.9743% (minimum 99%, Missing); lymph node: 64.4537% (minimum 97%, Missing); midbrain: 73.8510% (minimum 99%, Missing); pancreas: 64.9930% (minimum 99%, Missing); parathyroid gland: 61.0747% (minimum 97%, Missing); pituitary gland: 69.9700% (minimum 99%, Missing); rectum: 63.4014% (minimum 97%, Missing); retina: 77.5374% (minimum 99%, Missing); salivary gland: 59.8972% (minimum 97%, Missing); skeletal muscle: 51.8354% (minimum 98%, Approved); skin: 60.8355% (minimum 95%, Missing); small intestine: 65.4494% (minimum 99%, Missing); smooth muscle: 57.1779% (minimum 98%, Approved); spinal cord: 74.6795% (minimum 99%, Missing); spleen: 69.7605% (minimum 90%, Approved); stomach: 67.8311% (minimum 97%, Missing); thymus: 57.2482% (minimum 95%, Missing); thyroid gland: 55.5423% (minimum 95%, Missing); tongue: 53.6866% (minimum 97%, Missing); urinary bladder: 58.0324% (minimum 97%, Missing)",-0.41357,-0.433134,-0.461646,0,2,partial,43.3,40.2,49.2,"adipose tissue: 49.2 nTPM (manageable, limit 10); skeletal muscle: 43.3 nTPM (vital, limit 2); tongue: 40.2 nTPM (protected, limit 2); esophagus: 39.3 nTPM (protected, limit 4); thyroid gland: 37.3 nTPM (manageable, limit 5); colon: 37.1 nTPM (protected, limit 2); smooth muscle: 34.9 nTPM (vital, limit 2); thymus: 34.8 nTPM (manageable, limit 5); urinary bladder: 33.7 nTPM (protected, limit 2); heart muscle: 33.6 nTPM (vital, limit 2); adrenal gland: 33.4 nTPM (vital, limit 1); salivary gland: 31.2 nTPM (protected, limit 2); lung: 31.1 nTPM (vital, limit 1); skin: 30 nTPM (manageable, limit 5); parathyroid gland: 29.7 nTPM (protected, limit 2); bone marrow: 29.3 nTPM (vital, limit 2); rectum: 26.9 nTPM (protected, limit 2); lymph node: 25.7 nTPM (protected, limit 2); kidney: 25.1 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 2); duodenum: 20.6 nTPM (vital, limit 1); spleen: 20.2 nTPM (manageable, limit 10); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117868,ESYT2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6430% (minimum 60%, Approved); adrenal gland: 58.2500% (minimum 75%, Missing); basal ganglia: 70.4992% (minimum 75%, Missing); bone marrow: 61.3966% (minimum 70%, Approved); cerebellum: 67.3410% (minimum 75%, Missing); cerebral cortex: 70.9285% (minimum 75%, Missing); choroid plexus: 74.0859% (minimum 75%, Missing); colon: 55.6750% (minimum 70%, Missing); duodenum: 69.3452% (minimum 75%, Missing); esophagus: 54.2491% (minimum 65%, Approved); heart muscle: 58.1047% (minimum 70%, Approved); hippocampal formation: 72.4728% (minimum 75%, Missing); hypothalamus: 71.4724% (minimum 75%, Missing); kidney: 64.9930% (minimum 75%, Missing); liver: 67.6343% (minimum 75%, Missing); lung: 59.9743% (minimum 75%, Missing); lymph node: 64.4537% (minimum 70%, Missing); midbrain: 73.8510% (minimum 75%, Missing); pancreas: 64.9930% (minimum 75%, Missing); parathyroid gland: 61.0747% (minimum 70%, Missing); pituitary gland: 69.9700% (minimum 75%, Missing); rectum: 63.4014% (minimum 70%, Missing); salivary gland: 59.8972% (minimum 70%, Missing); skeletal muscle: 51.8354% (minimum 70%, Approved); skin: 60.8355% (minimum 65%, Missing); small intestine: 65.4494% (minimum 75%, Missing); smooth muscle: 57.1779% (minimum 70%, Approved); spinal cord: 74.6795% (minimum 75%, Missing); stomach: 67.8311% (minimum 70%, Missing); thymus: 57.2482% (minimum 65%, Missing); thyroid gland: 55.5423% (minimum 65%, Missing); tongue: 53.6866% (minimum 70%, Missing); urinary bladder: 58.0324% (minimum 70%, Missing)",-0.11357,-0.163134,-0.181646,0,2,partial,43.3,40.2,49.2,"adipose tissue: 49.2 nTPM (manageable, limit 10); skeletal muscle: 43.3 nTPM (vital, limit 2); tongue: 40.2 nTPM (protected, limit 2); esophagus: 39.3 nTPM (protected, limit 4); thyroid gland: 37.3 nTPM (manageable, limit 5); colon: 37.1 nTPM (protected, limit 2); smooth muscle: 34.9 nTPM (vital, limit 2); thymus: 34.8 nTPM (manageable, limit 5); urinary bladder: 33.7 nTPM (protected, limit 2); heart muscle: 33.6 nTPM (vital, limit 2); adrenal gland: 33.4 nTPM (vital, limit 1); salivary gland: 31.2 nTPM (protected, limit 2); lung: 31.1 nTPM (vital, limit 1); skin: 30 nTPM (manageable, limit 5); parathyroid gland: 29.7 nTPM (protected, limit 2); bone marrow: 29.3 nTPM (vital, limit 2); rectum: 26.9 nTPM (protected, limit 2); lymph node: 25.7 nTPM (protected, limit 2); kidney: 25.1 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 2); duodenum: 20.6 nTPM (vital, limit 1); spleen: 20.2 nTPM (manageable, limit 10); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117868,ESYT2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6430% (minimum 60%, Approved); adrenal gland: 58.2500% (minimum 75%, Missing); basal ganglia: 70.4992% (minimum 75%, Missing); bone marrow: 61.3966% (minimum 70%, Approved); cerebellum: 67.3410% (minimum 75%, Missing); cerebral cortex: 70.9285% (minimum 75%, Missing); choroid plexus: 74.0859% (minimum 75%, Missing); colon: 55.6750% (minimum 70%, Missing); duodenum: 69.3452% (minimum 75%, Missing); esophagus: 54.2491% (minimum 65%, Approved); heart muscle: 58.1047% (minimum 70%, Approved); hippocampal formation: 72.4728% (minimum 75%, Missing); hypothalamus: 71.4724% (minimum 75%, Missing); kidney: 64.9930% (minimum 75%, Missing); liver: 67.6343% (minimum 75%, Missing); lung: 59.9743% (minimum 75%, Missing); lymph node: 64.4537% (minimum 70%, Missing); midbrain: 73.8510% (minimum 75%, Missing); pancreas: 64.9930% (minimum 75%, Missing); parathyroid gland: 61.0747% (minimum 70%, Missing); pituitary gland: 69.9700% (minimum 75%, Missing); rectum: 63.4014% (minimum 70%, Missing); salivary gland: 59.8972% (minimum 70%, Missing); skeletal muscle: 51.8354% (minimum 70%, Approved); skin: 60.8355% (minimum 65%, Missing); small intestine: 65.4494% (minimum 75%, Missing); smooth muscle: 57.1779% (minimum 70%, Approved); spinal cord: 74.6795% (minimum 75%, Missing); stomach: 67.8311% (minimum 70%, Missing); thymus: 57.2482% (minimum 65%, Missing); thyroid gland: 55.5423% (minimum 65%, Missing); tongue: 53.6866% (minimum 70%, Missing); urinary bladder: 58.0324% (minimum 70%, Missing)",-0.11357,-0.163134,-0.181646,0,2,partial,43.3,40.2,49.2,"adipose tissue: 49.2 nTPM (manageable, limit 10); skeletal muscle: 43.3 nTPM (vital, limit 2); tongue: 40.2 nTPM (protected, limit 3); esophagus: 39.3 nTPM (protected, limit 4); thyroid gland: 37.3 nTPM (manageable, limit 5); colon: 37.1 nTPM (protected, limit 3); smooth muscle: 34.9 nTPM (vital, limit 2); thymus: 34.8 nTPM (manageable, limit 5); urinary bladder: 33.7 nTPM (protected, limit 3); heart muscle: 33.6 nTPM (vital, limit 2); adrenal gland: 33.4 nTPM (vital, limit 1); salivary gland: 31.2 nTPM (protected, limit 3); lung: 31.1 nTPM (vital, limit 1); skin: 30 nTPM (manageable, limit 5); parathyroid gland: 29.7 nTPM (protected, limit 3); bone marrow: 29.3 nTPM (vital, limit 2); rectum: 26.9 nTPM (protected, limit 3); lymph node: 25.7 nTPM (protected, limit 3); kidney: 25.1 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 3); duodenum: 20.6 nTPM (vital, limit 1); spleen: 20.2 nTPM (manageable, limit 10); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117868,ESYT2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6430% (minimum 60%, Approved); adrenal gland: 58.2500% (minimum 75%, Missing); basal ganglia: 70.4992% (minimum 75%, Missing); bone marrow: 61.3966% (minimum 70%, Approved); cerebellum: 67.3410% (minimum 75%, Missing); cerebral cortex: 70.9285% (minimum 75%, Missing); choroid plexus: 74.0859% (minimum 75%, Missing); colon: 55.6750% (minimum 70%, Missing); duodenum: 69.3452% (minimum 75%, Missing); esophagus: 54.2491% (minimum 65%, Approved); heart muscle: 58.1047% (minimum 70%, Approved); hippocampal formation: 72.4728% (minimum 75%, Missing); hypothalamus: 71.4724% (minimum 75%, Missing); kidney: 64.9930% (minimum 75%, Missing); liver: 67.6343% (minimum 75%, Missing); lung: 59.9743% (minimum 75%, Missing); lymph node: 64.4537% (minimum 70%, Missing); midbrain: 73.8510% (minimum 75%, Missing); pancreas: 64.9930% (minimum 75%, Missing); parathyroid gland: 61.0747% (minimum 70%, Missing); pituitary gland: 69.9700% (minimum 75%, Missing); rectum: 63.4014% (minimum 70%, Missing); salivary gland: 59.8972% (minimum 70%, Missing); skeletal muscle: 51.8354% (minimum 70%, Approved); skin: 60.8355% (minimum 65%, Missing); small intestine: 65.4494% (minimum 75%, Missing); smooth muscle: 57.1779% (minimum 70%, Approved); spinal cord: 74.6795% (minimum 75%, Missing); stomach: 67.8311% (minimum 70%, Missing); thymus: 57.2482% (minimum 65%, Missing); thyroid gland: 55.5423% (minimum 65%, Missing); tongue: 53.6866% (minimum 70%, Missing); urinary bladder: 58.0324% (minimum 70%, Missing)",-0.11357,-0.163134,-0.181646,0,2,partial,43.3,40.2,49.2,"adipose tissue: 49.2 nTPM (manageable, limit 10); skeletal muscle: 43.3 nTPM (vital, limit 2); tongue: 40.2 nTPM (protected, limit 3); esophagus: 39.3 nTPM (protected, limit 4); thyroid gland: 37.3 nTPM (manageable, limit 5); colon: 37.1 nTPM (protected, limit 3); smooth muscle: 34.9 nTPM (vital, limit 2); thymus: 34.8 nTPM (manageable, limit 5); urinary bladder: 33.7 nTPM (protected, limit 3); heart muscle: 33.6 nTPM (vital, limit 2); adrenal gland: 33.4 nTPM (vital, limit 1); salivary gland: 31.2 nTPM (protected, limit 3); lung: 31.1 nTPM (vital, limit 1); skin: 30 nTPM (manageable, limit 5); parathyroid gland: 29.7 nTPM (protected, limit 3); bone marrow: 29.3 nTPM (vital, limit 2); rectum: 26.9 nTPM (protected, limit 3); lymph node: 25.7 nTPM (protected, limit 3); kidney: 25.1 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 3); duodenum: 20.6 nTPM (vital, limit 1); spleen: 20.2 nTPM (manageable, limit 10); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117868,ESYT2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6430% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 58.2500% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.4992% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.3966% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.3410% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.9285% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.0859% (minimum 75%, Baseline (adaptation disabled)); colon: 55.6750% (minimum 70%, Baseline (adaptation disabled)); duodenum: 69.3452% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.2491% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.1047% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.4728% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.4724% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.9930% (minimum 75%, Baseline (adaptation disabled)); liver: 67.6343% (minimum 75%, Baseline (adaptation disabled)); lung: 59.9743% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.4537% (minimum 70%, Baseline (adaptation disabled)); midbrain: 73.8510% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.9930% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.0747% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.9700% (minimum 75%, Baseline (adaptation disabled)); rectum: 63.4014% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 59.8972% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 51.8354% (minimum 75%, Baseline (adaptation disabled)); skin: 60.8355% (minimum 65%, Baseline (adaptation disabled)); small intestine: 65.4494% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.1779% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.6795% (minimum 75%, Baseline (adaptation disabled)); stomach: 67.8311% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.2482% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.5423% (minimum 65%, Baseline (adaptation disabled)); tongue: 53.6866% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.0324% (minimum 70%, Baseline (adaptation disabled))",-0.16357,-0.163134,-0.231646,0,2,partial,43.3,40.2,49.2,"adipose tissue: 49.2 nTPM (manageable, limit 5); skeletal muscle: 43.3 nTPM (vital, limit 1); tongue: 40.2 nTPM (protected, limit 3); esophagus: 39.3 nTPM (protected, limit 3); thyroid gland: 37.3 nTPM (manageable, limit 5); colon: 37.1 nTPM (protected, limit 3); smooth muscle: 34.9 nTPM (vital, limit 1); thymus: 34.8 nTPM (manageable, limit 5); urinary bladder: 33.7 nTPM (protected, limit 3); heart muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 33.4 nTPM (vital, limit 1); salivary gland: 31.2 nTPM (protected, limit 3); lung: 31.1 nTPM (vital, limit 1); skin: 30 nTPM (manageable, limit 5); parathyroid gland: 29.7 nTPM (protected, limit 3); bone marrow: 29.3 nTPM (vital, limit 1); rectum: 26.9 nTPM (protected, limit 3); lymph node: 25.7 nTPM (protected, limit 3); kidney: 25.1 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 3); duodenum: 20.6 nTPM (vital, limit 1); spleen: 20.2 nTPM (manageable, limit 5); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117868,ESYT2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 99%, Missing); amygdala: 98.2456% (minimum 99%, Missing); basal ganglia: 98.2456% (minimum 99%, Missing); bone marrow: 91.8033% (minimum 99%, Missing); cerebral cortex: 98.2456% (minimum 99%, Missing); choroid plexus: 98.2456% (minimum 99%, Missing); colon: 84.8485% (minimum 97%, Missing); duodenum: 98.2456% (minimum 99%, Missing); esophagus: 90.3226% (minimum 97%, Missing); heart muscle: 98.2456% (minimum 99%, Missing); kidney: 96.5517% (minimum 99%, Missing); lung: 98.2456% (minimum 99%, Missing); lymph node: 91.8033% (minimum 97%, Missing); pancreas: 98.2456% (minimum 99%, Missing); parathyroid gland: 96.5517% (minimum 97%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); rectum: 93.3333% (minimum 97%, Missing); retina: 67.4699% (minimum 99%, Missing); skeletal muscle: 96.5517% (minimum 99%, Missing); small intestine: 93.3333% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spleen: 91.8033% (minimum 95%, Missing); stomach: 96.5517% (minimum 97%, Missing); thymus: 65.8824% (minimum 95%, Missing)",-0.291176,-0.121515,-0.315301,0,80,unavailable,2.7,1,2.9,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117971,CHRNB4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); retina: 67.4699% (minimum 75%, Missing)",0.00882353,0.148485,-0.0753012,0,80,unavailable,2.7,1,2.9,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117971,CHRNB4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); retina: 67.4699% (minimum 75%, Missing)",0.00882353,0.148485,-0.0753012,0,80,unavailable,2.7,1,2.9,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117971,CHRNB4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); retina: 67.4699% (minimum 75%, Missing)",0.00882353,0.148485,-0.0753012,0,80,unavailable,2.7,1,2.9,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117971,CHRNB4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 67.4699% (minimum 75%, Baseline (adaptation disabled))",0.00882353,0.148485,-0.0753012,0,80,unavailable,2.7,1,2.9,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000117971,CHRNB4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 87.3950% (minimum 95%, Enhanced); amygdala: 98.5782% (minimum 99%, Missing); hippocampal formation: 98.5782% (minimum 99%, Missing); hypothalamus: 98.5782% (minimum 99%, Missing); pituitary gland: 97.1963% (minimum 99%, Missing); retina: 97.6526% (minimum 99%, Missing)",0.0452153,0.0252153,-0.0760504,0,2,partial,3,0.7,1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118156,ZNF541,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.345215,0.295215,0.221963,0,2,partial,3,0.7,1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118156,ZNF541,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.345215,0.295215,0.221963,0,2,partial,3,0.7,1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118156,ZNF541,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.345215,0.295215,0.221963,0,2,partial,3,0.7,1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118156,ZNF541,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.304128,0.267442,0.12395,0,2,partial,3,0.7,1,"adrenal gland: 3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118156,ZNF541,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3077% (minimum 95%, Missing); adrenal gland: 92.3077% (minimum 99%, Missing); bone marrow: 26.9663% (minimum 99%, Missing); cerebral cortex: 92.3077% (minimum 99%, Missing); colon: 72.7273% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 70.5882% (minimum 97%, Missing); liver: 88.8889% (minimum 99%, Missing); lung: 92.3077% (minimum 99%, Missing); lymph node: 43.6364% (minimum 97%, Missing); rectum: 66.6667% (minimum 97%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); skin: 70.5882% (minimum 95%, Missing); small intestine: 70.5882% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thymus: 18.4615% (minimum 95%, Missing); urinary bladder: 85.7143% (minimum 97%, Missing)",-0.765385,-0.533636,-0.720337,0,80,unavailable,6.5,3.1,10.6,"thymus: 10.6 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118193,KIF14,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.9663% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); lymph node: 43.6364% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); small intestine: 70.5882% (minimum 75%, Missing); thymus: 18.4615% (minimum 65%, Missing)",-0.465385,-0.263636,-0.480337,0,80,unavailable,6.5,3.1,10.6,"thymus: 10.6 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118193,KIF14,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.9663% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); lymph node: 43.6364% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); small intestine: 70.5882% (minimum 75%, Missing); thymus: 18.4615% (minimum 65%, Missing)",-0.465385,-0.263636,-0.480337,0,80,unavailable,6.5,3.1,10.6,"thymus: 10.6 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118193,KIF14,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.9663% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); lymph node: 43.6364% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); small intestine: 70.5882% (minimum 75%, Missing); thymus: 18.4615% (minimum 65%, Missing)",-0.465385,-0.263636,-0.480337,0,80,unavailable,6.5,3.1,10.6,"thymus: 10.6 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118193,KIF14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.9663% (minimum 75%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lymph node: 43.6364% (minimum 70%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 70%, Baseline (adaptation disabled)); small intestine: 70.5882% (minimum 75%, Baseline (adaptation disabled)); thymus: 18.4615% (minimum 65%, Baseline (adaptation disabled))",-0.465385,-0.263636,-0.480337,0,80,unavailable,6.5,3.1,10.6,"thymus: 10.6 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118193,KIF14,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.00986179,0,4,partial,2.3,1,2.3,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118245,TNP1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249862,0,4,partial,2.3,1,2.3,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118245,TNP1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249862,0,4,partial,2.3,1,2.3,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118245,TNP1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249862,0,4,partial,2.3,1,2.3,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118245,TNP1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349603,0.299827,0.249603,0,4,partial,2.3,1,2.3,"skeletal muscle: 2.3 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118245,TNP1,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.6975% (minimum 99%, Missing); basal ganglia: 92.9167% (minimum 99%, Missing); cerebral cortex: 94.0928% (minimum 95%, Enhanced); choroid plexus: 61.6022% (minimum 99%, Missing); hippocampal formation: 92.5311% (minimum 99%, Missing); hypothalamus: 89.9194% (minimum 99%, Missing); kidney: 89.5582% (minimum 95%, Enhanced); lung: 92.5311% (minimum 99%, Missing); midbrain: 96.1207% (minimum 99%, Missing); pituitary gland: 85.1145% (minimum 99%, Missing); retina: 81.6850% (minimum 99%, Missing); spinal cord: 96.9565% (minimum 99%, Missing); thyroid gland: 84.7909% (minimum 95%, Missing)",-0.102091,0.03,-0.373978,0,7,partial,13.9,3.2,4,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118307,DNAI7,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 61.6022% (minimum 75%, Missing)",0.197909,0.3,-0.133978,0,7,partial,13.9,3.2,4,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118307,DNAI7,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 61.6022% (minimum 75%, Missing)",0.197909,0.3,-0.133978,0,7,partial,13.9,3.2,4,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118307,DNAI7,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 61.6022% (minimum 75%, Missing)",0.197909,0.3,-0.133978,0,7,partial,13.9,3.2,4,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118307,DNAI7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 61.6022% (minimum 75%, Baseline (adaptation disabled))",0.197909,0.17451,-0.133978,0,7,partial,13.9,3.2,4,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); kidney: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118307,DNAI7,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.0000% (minimum 90%, Approved); adrenal gland: 67.6056% (minimum 99%, Missing); amygdala: 72.7273% (minimum 99%, Missing); basal ganglia: 64.8649% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 99%, Missing); cerebellum: 67.6056% (minimum 99%, Missing); cerebral cortex: 63.1579% (minimum 99%, Missing); choroid plexus: 81.3559% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 69.5652% (minimum 99%, Missing); esophagus: 73.8462% (minimum 97%, Missing); heart muscle: 77.4194% (minimum 99%, Missing); hippocampal formation: 73.8462% (minimum 99%, Missing); hypothalamus: 64.0000% (minimum 99%, Missing); kidney: 69.5652% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lung: 81.3559% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 69.5652% (minimum 99%, Missing); pancreas: 68.5714% (minimum 99%, Missing); parathyroid gland: 71.6418% (minimum 97%, Missing); pituitary gland: 67.6056% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 59.2593% (minimum 99%, Missing); salivary gland: 72.7273% (minimum 97%, Missing); skeletal muscle: 64.8649% (minimum 99%, Missing); skin: 78.6885% (minimum 95%, Missing); small intestine: 77.4194% (minimum 99%, Missing); smooth muscle: 76.1905% (minimum 99%, Missing); spinal cord: 72.7273% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 73.8462% (minimum 97%, Missing); thymus: 69.5652% (minimum 95%, Missing); thyroid gland: 64.8649% (minimum 95%, Missing); tongue: 66.6667% (minimum 97%, Missing); urinary bladder: 70.5882% (minimum 97%, Missing)",-0.301351,-0.303333,-0.397407,0,3,partial,3.3,2.4,2.6,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118420,UBE3D,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.6056% (minimum 75%, Missing); amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 64.8649% (minimum 75%, Missing); cerebellum: 67.6056% (minimum 75%, Missing); cerebral cortex: 63.1579% (minimum 75%, Missing); duodenum: 69.5652% (minimum 75%, Missing); hippocampal formation: 73.8462% (minimum 75%, Missing); hypothalamus: 64.0000% (minimum 75%, Missing); kidney: 69.5652% (minimum 75%, Missing); midbrain: 69.5652% (minimum 75%, Missing); pancreas: 68.5714% (minimum 75%, Missing); pituitary gland: 67.6056% (minimum 75%, Missing); retina: 59.2593% (minimum 75%, Missing); skeletal muscle: 64.8649% (minimum 75%, Missing); spinal cord: 72.7273% (minimum 75%, Missing); thyroid gland: 64.8649% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing)",-0.00135135,-0.0333333,-0.157407,0,3,partial,3.3,2.4,2.6,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118420,UBE3D,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.6056% (minimum 75%, Missing); amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 64.8649% (minimum 75%, Missing); cerebellum: 67.6056% (minimum 75%, Missing); cerebral cortex: 63.1579% (minimum 75%, Missing); duodenum: 69.5652% (minimum 75%, Missing); hippocampal formation: 73.8462% (minimum 75%, Missing); hypothalamus: 64.0000% (minimum 75%, Missing); kidney: 69.5652% (minimum 75%, Missing); midbrain: 69.5652% (minimum 75%, Missing); pancreas: 68.5714% (minimum 75%, Missing); pituitary gland: 67.6056% (minimum 75%, Missing); retina: 59.2593% (minimum 75%, Missing); skeletal muscle: 64.8649% (minimum 75%, Missing); spinal cord: 72.7273% (minimum 75%, Missing); thyroid gland: 64.8649% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing)",-0.00135135,-0.0333333,-0.157407,0,3,partial,3.3,2.4,2.6,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118420,UBE3D,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.6056% (minimum 75%, Missing); amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 64.8649% (minimum 75%, Missing); cerebellum: 67.6056% (minimum 75%, Missing); cerebral cortex: 63.1579% (minimum 75%, Missing); duodenum: 69.5652% (minimum 75%, Missing); hippocampal formation: 73.8462% (minimum 75%, Missing); hypothalamus: 64.0000% (minimum 75%, Missing); kidney: 69.5652% (minimum 75%, Missing); midbrain: 69.5652% (minimum 75%, Missing); pancreas: 68.5714% (minimum 75%, Missing); pituitary gland: 67.6056% (minimum 75%, Missing); retina: 59.2593% (minimum 75%, Missing); skeletal muscle: 64.8649% (minimum 75%, Missing); spinal cord: 72.7273% (minimum 75%, Missing); thyroid gland: 64.8649% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing)",-0.00135135,-0.0333333,-0.157407,0,3,partial,3.3,2.4,2.6,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118420,UBE3D,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.6056% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.7273% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.8649% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.6056% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.1579% (minimum 75%, Baseline (adaptation disabled)); duodenum: 69.5652% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.8462% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.5652% (minimum 75%, Baseline (adaptation disabled)); midbrain: 69.5652% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.5714% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 67.6056% (minimum 75%, Baseline (adaptation disabled)); retina: 59.2593% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 64.8649% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.7273% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 64.8649% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 70%, Baseline (adaptation disabled))",-0.00135135,-0.0333333,-0.157407,0,3,partial,3.3,2.4,2.6,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118420,UBE3D,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118434,SPACA1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118434,SPACA1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118434,SPACA1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118434,SPACA1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247549,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118434,SPACA1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 98.6301% (minimum 99%, Missing)",0.0363014,0.0231034,-0.00369863,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118491,ZC2HC1B,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.336301,0.293103,0.236301,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118491,ZC2HC1B,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.336301,0.293103,0.236301,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118491,ZC2HC1B,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.336301,0.293103,0.236301,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118491,ZC2HC1B,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.336301,0.293103,0.236301,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118491,ZC2HC1B,current_fixed,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.3180% (minimum 99%, Missing); basal ganglia: 95.4887% (minimum 99%, Missing); choroid plexus: 84.1060% (minimum 99%, Missing); hippocampal formation: 95.4887% (minimum 99%, Missing); hypothalamus: 94.0741% (minimum 99%, Missing); pituitary gland: 98.8327% (minimum 99%, Missing); spinal cord: 98.8327% (minimum 99%, Missing)",0.05,0.0183268,-0.14894,0,5,partial,4.8,0.3,0,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118492,ADGB,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.288327,0.0910596,0,5,partial,4.8,0.3,0,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118492,ADGB,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.288327,0.0910596,0,5,partial,4.8,0.3,0,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118492,ADGB,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.288327,0.0910596,0,5,partial,4.8,0.3,0,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118492,ADGB,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.288327,0.0910596,0,5,partial,4.8,0.3,0,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118492,ADGB,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 16.8103% (minimum 95%, Missing); adrenal gland: 37.1429% (minimum 99%, Missing); amygdala: 84.7826% (minimum 99%, Missing); basal ganglia: 84.7826% (minimum 99%, Missing); bone marrow: 45.8824% (minimum 99%, Missing); cerebellum: 61.9048% (minimum 99%, Missing); cerebral cortex: 59.0909% (minimum 99%, Missing); choroid plexus: 78.0000% (minimum 99%, Missing); colon: 66.1017% (minimum 97%, Missing); duodenum: 72.2222% (minimum 99%, Missing); esophagus: 38.6139% (minimum 95%, Approved); heart muscle: 10.5121% (minimum 98%, Approved); hippocampal formation: 79.5918% (minimum 99%, Missing); hypothalamus: 84.7826% (minimum 99%, Missing); kidney: 25.8278% (minimum 99%, Missing); liver: 50.6494% (minimum 98%, Approved); lung: 47.5610% (minimum 99%, Missing); lymph node: 44.8276% (minimum 95%, Approved); midbrain: 81.2500% (minimum 99%, Missing); pancreas: 29.3233% (minimum 99%, Missing); parathyroid gland: 79.5918% (minimum 97%, Missing); pituitary gland: 73.5849% (minimum 99%, Missing); rectum: 61.9048% (minimum 97%, Missing); retina: 69.6429% (minimum 99%, Missing); salivary gland: 59.0909% (minimum 97%, Missing); skeletal muscle: 68.4211% (minimum 99%, Missing); skin: 33.9130% (minimum 90%, Approved); small intestine: 61.9048% (minimum 98%, Approved); smooth muscle: 53.4247% (minimum 98%, Approved); spinal cord: 70.9091% (minimum 99%, Missing); spleen: 39.0000% (minimum 90%, Approved); stomach: 28.6765% (minimum 97%, Missing); thymus: 46.9880% (minimum 95%, Missing); thyroid gland: 70.9091% (minimum 90%, Approved); tongue: 53.4247% (minimum 97%, Missing); urinary bladder: 50.6494% (minimum 97%, Missing)",-0.781897,-0.683235,-0.874879,0,7,partial,33.2,9.7,19.3,"heart muscle: 33.2 nTPM (vital, limit 2); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 2); pancreas: 9.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 4); lymph node: 4.8 nTPM (protected, limit 4); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 2); smooth muscle: 3.4 nTPM (vital, limit 2); tongue: 3.4 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 2); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118596,SLC16A7,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 16.8103% (minimum 65%, Missing); adrenal gland: 37.1429% (minimum 75%, Missing); bone marrow: 45.8824% (minimum 75%, Missing); cerebellum: 61.9048% (minimum 75%, Missing); cerebral cortex: 59.0909% (minimum 75%, Missing); colon: 66.1017% (minimum 70%, Missing); duodenum: 72.2222% (minimum 75%, Missing); esophagus: 38.6139% (minimum 65%, Approved); heart muscle: 10.5121% (minimum 70%, Approved); kidney: 25.8278% (minimum 75%, Missing); liver: 50.6494% (minimum 70%, Approved); lung: 47.5610% (minimum 75%, Missing); lymph node: 44.8276% (minimum 65%, Approved); pancreas: 29.3233% (minimum 75%, Missing); pituitary gland: 73.5849% (minimum 75%, Missing); rectum: 61.9048% (minimum 70%, Missing); retina: 69.6429% (minimum 75%, Missing); salivary gland: 59.0909% (minimum 70%, Missing); skeletal muscle: 68.4211% (minimum 75%, Missing); skin: 33.9130% (minimum 60%, Approved); small intestine: 61.9048% (minimum 70%, Approved); smooth muscle: 53.4247% (minimum 70%, Approved); spinal cord: 70.9091% (minimum 75%, Missing); spleen: 39.0000% (minimum 60%, Approved); stomach: 28.6765% (minimum 70%, Missing); thymus: 46.9880% (minimum 65%, Missing); tongue: 53.4247% (minimum 70%, Missing); urinary bladder: 50.6494% (minimum 70%, Missing)",-0.481897,-0.413235,-0.594879,0,7,partial,33.2,9.7,19.3,"heart muscle: 33.2 nTPM (vital, limit 2); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 2); pancreas: 9.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 4); lymph node: 4.8 nTPM (protected, limit 4); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 2); smooth muscle: 3.4 nTPM (vital, limit 2); tongue: 3.4 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 2); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118596,SLC16A7,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 16.8103% (minimum 65%, Missing); adrenal gland: 37.1429% (minimum 75%, Missing); bone marrow: 45.8824% (minimum 75%, Missing); cerebellum: 61.9048% (minimum 75%, Missing); cerebral cortex: 59.0909% (minimum 75%, Missing); colon: 66.1017% (minimum 70%, Missing); duodenum: 72.2222% (minimum 75%, Missing); esophagus: 38.6139% (minimum 65%, Approved); heart muscle: 10.5121% (minimum 70%, Approved); kidney: 25.8278% (minimum 75%, Missing); liver: 50.6494% (minimum 70%, Approved); lung: 47.5610% (minimum 75%, Missing); lymph node: 44.8276% (minimum 65%, Approved); pancreas: 29.3233% (minimum 75%, Missing); pituitary gland: 73.5849% (minimum 75%, Missing); rectum: 61.9048% (minimum 70%, Missing); retina: 69.6429% (minimum 75%, Missing); salivary gland: 59.0909% (minimum 70%, Missing); skeletal muscle: 68.4211% (minimum 75%, Missing); skin: 33.9130% (minimum 60%, Approved); small intestine: 61.9048% (minimum 70%, Approved); smooth muscle: 53.4247% (minimum 70%, Approved); spinal cord: 70.9091% (minimum 75%, Missing); spleen: 39.0000% (minimum 60%, Approved); stomach: 28.6765% (minimum 70%, Missing); thymus: 46.9880% (minimum 65%, Missing); tongue: 53.4247% (minimum 70%, Missing); urinary bladder: 50.6494% (minimum 70%, Missing)",-0.481897,-0.413235,-0.594879,0,7,partial,33.2,9.7,19.3,"heart muscle: 33.2 nTPM (vital, limit 2); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 3); pancreas: 9.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 4); lymph node: 4.8 nTPM (protected, limit 4); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 2); urinary bladder: 3.8 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 2); tongue: 3.4 nTPM (protected, limit 3); cerebral cortex: 2.7 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118596,SLC16A7,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 16.8103% (minimum 65%, Missing); adrenal gland: 37.1429% (minimum 75%, Missing); bone marrow: 45.8824% (minimum 75%, Missing); cerebellum: 61.9048% (minimum 75%, Missing); cerebral cortex: 59.0909% (minimum 75%, Missing); colon: 66.1017% (minimum 70%, Missing); duodenum: 72.2222% (minimum 75%, Missing); esophagus: 38.6139% (minimum 65%, Approved); heart muscle: 10.5121% (minimum 70%, Approved); kidney: 25.8278% (minimum 75%, Missing); liver: 50.6494% (minimum 70%, Approved); lung: 47.5610% (minimum 75%, Missing); lymph node: 44.8276% (minimum 65%, Approved); pancreas: 29.3233% (minimum 75%, Missing); pituitary gland: 73.5849% (minimum 75%, Missing); rectum: 61.9048% (minimum 70%, Missing); retina: 69.6429% (minimum 75%, Missing); salivary gland: 59.0909% (minimum 70%, Missing); skeletal muscle: 68.4211% (minimum 75%, Missing); skin: 33.9130% (minimum 60%, Approved); small intestine: 61.9048% (minimum 70%, Approved); smooth muscle: 53.4247% (minimum 70%, Approved); spinal cord: 70.9091% (minimum 75%, Missing); spleen: 39.0000% (minimum 60%, Approved); stomach: 28.6765% (minimum 70%, Missing); thymus: 46.9880% (minimum 65%, Missing); tongue: 53.4247% (minimum 70%, Missing); urinary bladder: 50.6494% (minimum 70%, Missing)",-0.481897,-0.413235,-0.594879,0,7,partial,33.2,9.7,19.3,"heart muscle: 33.2 nTPM (vital, limit 2); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 3); pancreas: 9.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 4); lymph node: 4.8 nTPM (protected, limit 4); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 2); urinary bladder: 3.8 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 2); tongue: 3.4 nTPM (protected, limit 3); cerebral cortex: 2.7 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118596,SLC16A7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 16.8103% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 37.1429% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 45.8824% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.9048% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 59.0909% (minimum 75%, Baseline (adaptation disabled)); colon: 66.1017% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.2222% (minimum 75%, Baseline (adaptation disabled)); esophagus: 38.6139% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 10.5121% (minimum 75%, Baseline (adaptation disabled)); kidney: 25.8278% (minimum 75%, Baseline (adaptation disabled)); liver: 50.6494% (minimum 75%, Baseline (adaptation disabled)); lung: 47.5610% (minimum 75%, Baseline (adaptation disabled)); lymph node: 44.8276% (minimum 70%, Baseline (adaptation disabled)); pancreas: 29.3233% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 73.5849% (minimum 75%, Baseline (adaptation disabled)); rectum: 61.9048% (minimum 70%, Baseline (adaptation disabled)); retina: 69.6429% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.0909% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 68.4211% (minimum 75%, Baseline (adaptation disabled)); skin: 33.9130% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.9048% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.4247% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.9091% (minimum 75%, Baseline (adaptation disabled)); spleen: 39.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 28.6765% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.9880% (minimum 65%, Baseline (adaptation disabled)); tongue: 53.4247% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 50.6494% (minimum 70%, Baseline (adaptation disabled))",-0.481897,-0.413235,-0.644879,0,7,partial,33.2,9.7,19.3,"heart muscle: 33.2 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 3); pancreas: 9.4 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 3); spleen: 6.1 nTPM (manageable, limit 5); lymph node: 4.8 nTPM (protected, limit 3); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); cerebral cortex: 2.7 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118596,SLC16A7,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.6978% (minimum 95%, Missing); adrenal gland: 78.8321% (minimum 99%, Missing); amygdala: 83.7209% (minimum 99%, Missing); basal ganglia: 76.0563% (minimum 99%, Missing); bone marrow: 48.2143% (minimum 99%, Missing); cerebellum: 72.4832% (minimum 99%, Missing); cerebral cortex: 74.4828% (minimum 99%, Missing); choroid plexus: 96.4286% (minimum 99%, Missing); colon: 78.2609% (minimum 97%, Missing); duodenum: 76.0563% (minimum 99%, Missing); esophagus: 62.0690% (minimum 97%, Missing); heart muscle: 85.7143% (minimum 99%, Missing); hippocampal formation: 83.0769% (minimum 99%, Missing); hypothalamus: 84.3750% (minimum 99%, Missing); kidney: 80.5970% (minimum 99%, Missing); liver: 91.5254% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 51.6746% (minimum 97%, Missing); midbrain: 82.4427% (minimum 99%, Missing); pancreas: 72.9730% (minimum 99%, Missing); parathyroid gland: 59.0164% (minimum 97%, Missing); pituitary gland: 85.7143% (minimum 99%, Missing); rectum: 72.4832% (minimum 97%, Missing); retina: 80.0000% (minimum 99%, Missing); salivary gland: 76.0563% (minimum 97%, Missing); skeletal muscle: 87.8049% (minimum 99%, Missing); skin: 60.0000% (minimum 95%, Missing); small intestine: 76.0563% (minimum 99%, Missing); smooth muscle: 76.5957% (minimum 99%, Missing); spinal cord: 77.1429% (minimum 99%, Missing); spleen: 62.7907% (minimum 95%, Missing); stomach: 69.2308% (minimum 97%, Missing); thymus: 53.2020% (minimum 95%, Missing); thyroid gland: 56.8421% (minimum 95%, Missing); tongue: 80.5970% (minimum 97%, Missing); urinary bladder: 71.0526% (minimum 97%, Missing)",-0.41798,-0.453254,-0.507857,0,80,unavailable,11.6,10.1,9.5,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 2); thymus: 9.5 nTPM (manageable, limit 5); thyroid gland: 8.2 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 2); skin: 7.2 nTPM (manageable, limit 5); esophagus: 6.6 nTPM (protected, limit 2); spleen: 6.4 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); cerebellum: 4.1 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118620,ZNF430,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.2143% (minimum 75%, Missing); cerebellum: 72.4832% (minimum 75%, Missing); cerebral cortex: 74.4828% (minimum 75%, Missing); esophagus: 62.0690% (minimum 70%, Missing); lymph node: 51.6746% (minimum 70%, Missing); pancreas: 72.9730% (minimum 75%, Missing); parathyroid gland: 59.0164% (minimum 70%, Missing); skin: 60.0000% (minimum 65%, Missing); spleen: 62.7907% (minimum 65%, Missing); stomach: 69.2308% (minimum 70%, Missing); thymus: 53.2020% (minimum 65%, Missing); thyroid gland: 56.8421% (minimum 65%, Missing)",-0.11798,-0.183254,-0.267857,0,80,unavailable,11.6,10.1,9.5,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 2); thymus: 9.5 nTPM (manageable, limit 5); thyroid gland: 8.2 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 2); skin: 7.2 nTPM (manageable, limit 5); esophagus: 6.6 nTPM (protected, limit 2); spleen: 6.4 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); cerebellum: 4.1 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118620,ZNF430,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.2143% (minimum 75%, Missing); cerebellum: 72.4832% (minimum 75%, Missing); cerebral cortex: 74.4828% (minimum 75%, Missing); esophagus: 62.0690% (minimum 70%, Missing); lymph node: 51.6746% (minimum 70%, Missing); pancreas: 72.9730% (minimum 75%, Missing); parathyroid gland: 59.0164% (minimum 70%, Missing); skin: 60.0000% (minimum 65%, Missing); spleen: 62.7907% (minimum 65%, Missing); stomach: 69.2308% (minimum 70%, Missing); thymus: 53.2020% (minimum 65%, Missing); thyroid gland: 56.8421% (minimum 65%, Missing)",-0.11798,-0.183254,-0.267857,0,80,unavailable,11.6,10.1,9.5,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 3); thymus: 9.5 nTPM (manageable, limit 5); thyroid gland: 8.2 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 3); skin: 7.2 nTPM (manageable, limit 5); esophagus: 6.6 nTPM (protected, limit 3); spleen: 6.4 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); urinary bladder: 4.4 nTPM (protected, limit 3); cerebellum: 4.1 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 3); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118620,ZNF430,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.2143% (minimum 75%, Missing); cerebellum: 72.4832% (minimum 75%, Missing); cerebral cortex: 74.4828% (minimum 75%, Missing); esophagus: 62.0690% (minimum 70%, Missing); lymph node: 51.6746% (minimum 70%, Missing); pancreas: 72.9730% (minimum 75%, Missing); parathyroid gland: 59.0164% (minimum 70%, Missing); skin: 60.0000% (minimum 65%, Missing); spleen: 62.7907% (minimum 65%, Missing); stomach: 69.2308% (minimum 70%, Missing); thymus: 53.2020% (minimum 65%, Missing); thyroid gland: 56.8421% (minimum 65%, Missing)",-0.11798,-0.183254,-0.267857,0,80,unavailable,11.6,10.1,9.5,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 3); thymus: 9.5 nTPM (manageable, limit 5); thyroid gland: 8.2 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 3); skin: 7.2 nTPM (manageable, limit 5); esophagus: 6.6 nTPM (protected, limit 3); spleen: 6.4 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); urinary bladder: 4.4 nTPM (protected, limit 3); cerebellum: 4.1 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 3); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118620,ZNF430,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.2143% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.4832% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.4828% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.0690% (minimum 70%, Baseline (adaptation disabled)); lymph node: 51.6746% (minimum 70%, Baseline (adaptation disabled)); pancreas: 72.9730% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.0164% (minimum 70%, Baseline (adaptation disabled)); skin: 60.0000% (minimum 65%, Baseline (adaptation disabled)); spleen: 62.7907% (minimum 65%, Baseline (adaptation disabled)); stomach: 69.2308% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.2020% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.8421% (minimum 65%, Baseline (adaptation disabled))",-0.11798,-0.183254,-0.267857,0,80,unavailable,11.6,10.1,9.5,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 3); thymus: 9.5 nTPM (manageable, limit 5); thyroid gland: 8.2 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 3); skin: 7.2 nTPM (manageable, limit 5); esophagus: 6.6 nTPM (protected, limit 3); spleen: 6.4 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); urinary bladder: 4.4 nTPM (protected, limit 3); cerebellum: 4.1 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 3); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118620,ZNF430,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.8621% (minimum 90%, Approved); adrenal gland: 69.1824% (minimum 98%, Approved); amygdala: 75.8621% (minimum 99%, Missing); basal ganglia: 70.9677% (minimum 99%, Missing); bone marrow: 84.6154% (minimum 99%, Missing); cerebellum: 82.0896% (minimum 99%, Missing); cerebral cortex: 68.7500% (minimum 99%, Missing); choroid plexus: 45.6432% (minimum 99%, Missing); colon: 70.0637% (minimum 97%, Missing); duodenum: 86.6142% (minimum 99%, Missing); esophagus: 79.7101% (minimum 97%, Missing); heart muscle: 77.4648% (minimum 99%, Missing); hippocampal formation: 75.3425% (minimum 99%, Missing); hypothalamus: 70.5128% (minimum 99%, Missing); kidney: 59.1398% (minimum 99%, Missing); liver: 85.2713% (minimum 99%, Missing); lung: 71.8954% (minimum 99%, Missing); lymph node: 80.8824% (minimum 97%, Missing); midbrain: 74.8299% (minimum 99%, Missing); pancreas: 74.8299% (minimum 99%, Missing); parathyroid gland: 44.1767% (minimum 97%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); rectum: 79.1367% (minimum 97%, Missing); retina: 47.4138% (minimum 99%, Missing); salivary gland: 79.1367% (minimum 97%, Missing); skeletal muscle: 82.0896% (minimum 98%, Approved); skin: 76.9231% (minimum 95%, Missing); small intestine: 79.1367% (minimum 99%, Missing); smooth muscle: 64.7059% (minimum 98%, Approved); spinal cord: 75.3425% (minimum 99%, Missing); spleen: 84.6154% (minimum 95%, Missing); stomach: 75.8621% (minimum 97%, Missing); thymus: 70.0637% (minimum 95%, Missing); thyroid gland: 56.4103% (minimum 95%, Missing); tongue: 81.4815% (minimum 97%, Missing); urinary bladder: 71.8954% (minimum 95%, Approved)",-0.385897,-0.528233,-0.533568,0,6,partial,13.1,13.9,8.5,"parathyroid gland: 13.9 nTPM (protected, limit 2); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 2); colon: 4.7 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 4); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); heart muscle: 3.2 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); tongue: 2.5 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 2); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118965,WDR35,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.1824% (minimum 70%, Approved); basal ganglia: 70.9677% (minimum 75%, Missing); cerebral cortex: 68.7500% (minimum 75%, Missing); choroid plexus: 45.6432% (minimum 75%, Missing); hypothalamus: 70.5128% (minimum 75%, Missing); kidney: 59.1398% (minimum 75%, Missing); lung: 71.8954% (minimum 75%, Missing); midbrain: 74.8299% (minimum 75%, Missing); pancreas: 74.8299% (minimum 75%, Missing); parathyroid gland: 44.1767% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 47.4138% (minimum 75%, Missing); smooth muscle: 64.7059% (minimum 70%, Approved); thyroid gland: 56.4103% (minimum 65%, Missing)",-0.0858974,-0.258233,-0.293568,0,6,partial,13.1,13.9,8.5,"parathyroid gland: 13.9 nTPM (protected, limit 2); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 2); colon: 4.7 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 4); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); heart muscle: 3.2 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); tongue: 2.5 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 2); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118965,WDR35,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.1824% (minimum 70%, Approved); basal ganglia: 70.9677% (minimum 75%, Missing); cerebral cortex: 68.7500% (minimum 75%, Missing); choroid plexus: 45.6432% (minimum 75%, Missing); hypothalamus: 70.5128% (minimum 75%, Missing); kidney: 59.1398% (minimum 75%, Missing); lung: 71.8954% (minimum 75%, Missing); midbrain: 74.8299% (minimum 75%, Missing); pancreas: 74.8299% (minimum 75%, Missing); parathyroid gland: 44.1767% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 47.4138% (minimum 75%, Missing); smooth muscle: 64.7059% (minimum 70%, Approved); thyroid gland: 56.4103% (minimum 65%, Missing)",-0.0858974,-0.258233,-0.293568,0,6,partial,13.1,13.9,8.5,"parathyroid gland: 13.9 nTPM (protected, limit 3); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 2); colon: 4.7 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 4); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); heart muscle: 3.2 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118965,WDR35,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.1824% (minimum 70%, Approved); basal ganglia: 70.9677% (minimum 75%, Missing); cerebral cortex: 68.7500% (minimum 75%, Missing); choroid plexus: 45.6432% (minimum 75%, Missing); hypothalamus: 70.5128% (minimum 75%, Missing); kidney: 59.1398% (minimum 75%, Missing); lung: 71.8954% (minimum 75%, Missing); midbrain: 74.8299% (minimum 75%, Missing); pancreas: 74.8299% (minimum 75%, Missing); parathyroid gland: 44.1767% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 47.4138% (minimum 75%, Missing); smooth muscle: 64.7059% (minimum 70%, Approved); thyroid gland: 56.4103% (minimum 65%, Missing)",-0.0858974,-0.258233,-0.293568,0,6,partial,13.1,13.9,8.5,"parathyroid gland: 13.9 nTPM (protected, limit 3); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 2); colon: 4.7 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 4); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); heart muscle: 3.2 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118965,WDR35,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.1824% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.9677% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.7500% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 45.6432% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 70.5128% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.1398% (minimum 75%, Baseline (adaptation disabled)); lung: 71.8954% (minimum 75%, Baseline (adaptation disabled)); midbrain: 74.8299% (minimum 75%, Baseline (adaptation disabled)); pancreas: 74.8299% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 44.1767% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 75%, Baseline (adaptation disabled)); retina: 47.4138% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.7059% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 56.4103% (minimum 65%, Baseline (adaptation disabled))",-0.0858974,-0.258233,-0.293568,0,6,partial,13.1,13.9,8.5,"parathyroid gland: 13.9 nTPM (protected, limit 3); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); heart muscle: 3.2 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118965,WDR35,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.1053% (minimum 99%, Missing); amygdala: 66.0377% (minimum 99%, Missing); basal ganglia: 55.2632% (minimum 99%, Missing); cerebral cortex: 62.5000% (minimum 95%, Enhanced); choroid plexus: 33.9806% (minimum 99%, Missing); hippocampal formation: 69.5364% (minimum 99%, Missing); hypothalamus: 69.0789% (minimum 99%, Missing); kidney: 76.0870% (minimum 95%, Enhanced); lung: 82.6772% (minimum 95%, Enhanced); midbrain: 78.3582% (minimum 99%, Missing); pancreas: 80.1527% (minimum 95%, Enhanced); pituitary gland: 60.0000% (minimum 99%, Missing); retina: 54.6875% (minimum 99%, Missing); small intestine: 93.7500% (minimum 95%, Enhanced); spinal cord: 92.9204% (minimum 99%, Missing); stomach: 94.5946% (minimum 97%, Missing); thyroid gland: 77.2059% (minimum 95%, Missing)",-0.177941,-0.0240541,-0.650194,0,6,partial,20.4,1.9,3.1,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 6); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118997,DNAH7,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 66.0377% (minimum 75%, Missing); basal ganglia: 55.2632% (minimum 75%, Missing); choroid plexus: 33.9806% (minimum 75%, Missing); hippocampal formation: 69.5364% (minimum 75%, Missing); hypothalamus: 69.0789% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 54.6875% (minimum 75%, Missing)",0.122059,0.245946,-0.410194,0,6,partial,20.4,1.9,3.1,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 6); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118997,DNAH7,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 66.0377% (minimum 75%, Missing); basal ganglia: 55.2632% (minimum 75%, Missing); choroid plexus: 33.9806% (minimum 75%, Missing); hippocampal formation: 69.5364% (minimum 75%, Missing); hypothalamus: 69.0789% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 54.6875% (minimum 75%, Missing)",0.122059,0.245946,-0.410194,0,6,partial,20.4,1.9,3.1,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 6); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118997,DNAH7,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 66.0377% (minimum 75%, Missing); basal ganglia: 55.2632% (minimum 75%, Missing); choroid plexus: 33.9806% (minimum 75%, Missing); hippocampal formation: 69.5364% (minimum 75%, Missing); hypothalamus: 69.0789% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 54.6875% (minimum 75%, Missing)",0.122059,0.245946,-0.410194,0,6,partial,20.4,1.9,3.1,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 6); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118997,DNAH7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 66.0377% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.2632% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.5000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 33.9806% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 69.5364% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.0789% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 54.6875% (minimum 75%, Baseline (adaptation disabled))",0.122059,0.146774,-0.410194,0,6,partial,20.4,1.9,3.1,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000118997,DNAH7,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.1429% (minimum 95%, Missing); adrenal gland: 74.8148% (minimum 99%, Missing); amygdala: 67.5585% (minimum 99%, Missing); basal ganglia: 68.4746% (minimum 99%, Missing); bone marrow: 56.4246% (minimum 99%, Missing); cerebellum: 56.5826% (minimum 99%, Missing); cerebral cortex: 63.7224% (minimum 99%, Missing); choroid plexus: 75.0929% (minimum 99%, Missing); colon: 67.1096% (minimum 97%, Missing); duodenum: 77.9923% (minimum 99%, Missing); esophagus: 71.1268% (minimum 97%, Missing); heart muscle: 69.1781% (minimum 99%, Missing); hippocampal formation: 65.1613% (minimum 99%, Missing); hypothalamus: 62.5387% (minimum 99%, Missing); kidney: 72.6619% (minimum 99%, Missing); liver: 67.3333% (minimum 99%, Missing); lung: 67.7852% (minimum 99%, Missing); lymph node: 69.6552% (minimum 97%, Missing); midbrain: 65.3722% (minimum 99%, Missing); pancreas: 72.1429% (minimum 99%, Missing); parathyroid gland: 70.3833% (minimum 97%, Missing); pituitary gland: 66.8874% (minimum 99%, Missing); rectum: 75.0929% (minimum 97%, Missing); retina: 54.4474% (minimum 99%, Missing); salivary gland: 72.9242% (minimum 97%, Missing); skeletal muscle: 63.9241% (minimum 99%, Missing); skin: 68.9420% (minimum 95%, Missing); small intestine: 71.3781% (minimum 99%, Missing); smooth muscle: 72.6619% (minimum 99%, Missing); spinal cord: 65.5844% (minimum 99%, Missing); spleen: 66.4474% (minimum 95%, Missing); stomach: 71.6312% (minimum 97%, Missing); thymus: 66.2295% (minimum 95%, Missing); thyroid gland: 71.3781% (minimum 95%, Missing); tongue: 63.3229% (minimum 97%, Missing); urinary bladder: 69.8962% (minimum 97%, Missing)",-0.287705,-0.336771,-0.445526,0,80,unavailable,16.9,11.7,10.3,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 2); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); thymus: 10.3 nTPM (manageable, limit 5); spleen: 10.2 nTPM (manageable, limit 5); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 2); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); urinary bladder: 8.7 nTPM (protected, limit 2); parathyroid gland: 8.5 nTPM (protected, limit 2); esophagus: 8.2 nTPM (protected, limit 2); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); stomach: 8 nTPM (protected, limit 2); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 7.6 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119231,SENP5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.8148% (minimum 75%, Missing); amygdala: 67.5585% (minimum 75%, Missing); basal ganglia: 68.4746% (minimum 75%, Missing); bone marrow: 56.4246% (minimum 75%, Missing); cerebellum: 56.5826% (minimum 75%, Missing); cerebral cortex: 63.7224% (minimum 75%, Missing); colon: 67.1096% (minimum 70%, Missing); heart muscle: 69.1781% (minimum 75%, Missing); hippocampal formation: 65.1613% (minimum 75%, Missing); hypothalamus: 62.5387% (minimum 75%, Missing); kidney: 72.6619% (minimum 75%, Missing); liver: 67.3333% (minimum 75%, Missing); lung: 67.7852% (minimum 75%, Missing); lymph node: 69.6552% (minimum 70%, Missing); midbrain: 65.3722% (minimum 75%, Missing); pancreas: 72.1429% (minimum 75%, Missing); pituitary gland: 66.8874% (minimum 75%, Missing); retina: 54.4474% (minimum 75%, Missing); skeletal muscle: 63.9241% (minimum 75%, Missing); small intestine: 71.3781% (minimum 75%, Missing); smooth muscle: 72.6619% (minimum 75%, Missing); spinal cord: 65.5844% (minimum 75%, Missing); tongue: 63.3229% (minimum 70%, Missing); urinary bladder: 69.8962% (minimum 70%, Missing)",0.0122951,-0.0667712,-0.205526,0,80,unavailable,16.9,11.7,10.3,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 2); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); thymus: 10.3 nTPM (manageable, limit 5); spleen: 10.2 nTPM (manageable, limit 5); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 2); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); urinary bladder: 8.7 nTPM (protected, limit 2); parathyroid gland: 8.5 nTPM (protected, limit 2); esophagus: 8.2 nTPM (protected, limit 2); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); stomach: 8 nTPM (protected, limit 2); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 7.6 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119231,SENP5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.8148% (minimum 75%, Missing); amygdala: 67.5585% (minimum 75%, Missing); basal ganglia: 68.4746% (minimum 75%, Missing); bone marrow: 56.4246% (minimum 75%, Missing); cerebellum: 56.5826% (minimum 75%, Missing); cerebral cortex: 63.7224% (minimum 75%, Missing); colon: 67.1096% (minimum 70%, Missing); heart muscle: 69.1781% (minimum 75%, Missing); hippocampal formation: 65.1613% (minimum 75%, Missing); hypothalamus: 62.5387% (minimum 75%, Missing); kidney: 72.6619% (minimum 75%, Missing); liver: 67.3333% (minimum 75%, Missing); lung: 67.7852% (minimum 75%, Missing); lymph node: 69.6552% (minimum 70%, Missing); midbrain: 65.3722% (minimum 75%, Missing); pancreas: 72.1429% (minimum 75%, Missing); pituitary gland: 66.8874% (minimum 75%, Missing); retina: 54.4474% (minimum 75%, Missing); skeletal muscle: 63.9241% (minimum 75%, Missing); small intestine: 71.3781% (minimum 75%, Missing); smooth muscle: 72.6619% (minimum 75%, Missing); spinal cord: 65.5844% (minimum 75%, Missing); tongue: 63.3229% (minimum 70%, Missing); urinary bladder: 69.8962% (minimum 70%, Missing)",0.0122951,-0.0667712,-0.205526,0,80,unavailable,16.9,11.7,10.3,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 3); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); thymus: 10.3 nTPM (manageable, limit 5); spleen: 10.2 nTPM (manageable, limit 5); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 3); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); urinary bladder: 8.7 nTPM (protected, limit 3); parathyroid gland: 8.5 nTPM (protected, limit 3); esophagus: 8.2 nTPM (protected, limit 3); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); stomach: 8 nTPM (protected, limit 3); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 7.6 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 3); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119231,SENP5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.8148% (minimum 75%, Missing); amygdala: 67.5585% (minimum 75%, Missing); basal ganglia: 68.4746% (minimum 75%, Missing); bone marrow: 56.4246% (minimum 75%, Missing); cerebellum: 56.5826% (minimum 75%, Missing); cerebral cortex: 63.7224% (minimum 75%, Missing); colon: 67.1096% (minimum 70%, Missing); heart muscle: 69.1781% (minimum 75%, Missing); hippocampal formation: 65.1613% (minimum 75%, Missing); hypothalamus: 62.5387% (minimum 75%, Missing); kidney: 72.6619% (minimum 75%, Missing); liver: 67.3333% (minimum 75%, Missing); lung: 67.7852% (minimum 75%, Missing); lymph node: 69.6552% (minimum 70%, Missing); midbrain: 65.3722% (minimum 75%, Missing); pancreas: 72.1429% (minimum 75%, Missing); pituitary gland: 66.8874% (minimum 75%, Missing); retina: 54.4474% (minimum 75%, Missing); skeletal muscle: 63.9241% (minimum 75%, Missing); small intestine: 71.3781% (minimum 75%, Missing); smooth muscle: 72.6619% (minimum 75%, Missing); spinal cord: 65.5844% (minimum 75%, Missing); tongue: 63.3229% (minimum 70%, Missing); urinary bladder: 69.8962% (minimum 70%, Missing)",0.0122951,-0.0667712,-0.205526,0,80,unavailable,16.9,11.7,10.3,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 3); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); thymus: 10.3 nTPM (manageable, limit 5); spleen: 10.2 nTPM (manageable, limit 5); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 3); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); urinary bladder: 8.7 nTPM (protected, limit 3); parathyroid gland: 8.5 nTPM (protected, limit 3); esophagus: 8.2 nTPM (protected, limit 3); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); stomach: 8 nTPM (protected, limit 3); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 7.6 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 3); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119231,SENP5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.8148% (minimum 75%, Baseline (adaptation disabled)); amygdala: 67.5585% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 68.4746% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 56.4246% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.5826% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.7224% (minimum 75%, Baseline (adaptation disabled)); colon: 67.1096% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.1781% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.1613% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.5387% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.6619% (minimum 75%, Baseline (adaptation disabled)); liver: 67.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 67.7852% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.6552% (minimum 70%, Baseline (adaptation disabled)); midbrain: 65.3722% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.1429% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 66.8874% (minimum 75%, Baseline (adaptation disabled)); retina: 54.4474% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 63.9241% (minimum 75%, Baseline (adaptation disabled)); small intestine: 71.3781% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.6619% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.5844% (minimum 75%, Baseline (adaptation disabled)); tongue: 63.3229% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 69.8962% (minimum 70%, Baseline (adaptation disabled))",0.0122951,-0.0667712,-0.205526,0,80,unavailable,16.9,11.7,10.3,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 3); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); thymus: 10.3 nTPM (manageable, limit 5); spleen: 10.2 nTPM (manageable, limit 5); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 3); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); urinary bladder: 8.7 nTPM (protected, limit 3); parathyroid gland: 8.5 nTPM (protected, limit 3); esophagus: 8.2 nTPM (protected, limit 3); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); stomach: 8 nTPM (protected, limit 3); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 7.6 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 3); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119231,SENP5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.0000% (minimum 95%, Enhanced); basal ganglia: 2.9412% (minimum 99%, Missing); cerebellum: 12.5000% (minimum 95%, Enhanced); cerebral cortex: 20.0000% (minimum 95%, Enhanced); duodenum: 1.0000% (minimum 95%, Enhanced); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 25.0000% (minimum 99%, Missing); kidney: 50.0000% (minimum 95%, Enhanced); liver: 1.2048% (minimum 95%, Enhanced); pancreas: 4.1667% (minimum 95%, Enhanced); parathyroid gland: 11.1111% (minimum 80%, Enhanced); pituitary gland: 11.1111% (minimum 99%, Missing); retina: 1.8519% (minimum 99%, Missing); small intestine: 4.5455% (minimum 99%, Missing); stomach: 50.0000% (minimum 80%, Enhanced)",0.05,-0.688889,-0.971481,0,3,partial,9.9,0.8,0,"duodenum: 9.9 nTPM (vital, limit 6); liver: 8.2 nTPM (vital, limit 6); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Enhanced),52,not_established,required,in_situ_inflammation_review,gallbladder; gallbladder / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119547,ONECUT2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.0000% (minimum 60%, Enhanced); basal ganglia: 2.9412% (minimum 75%, Missing); cerebellum: 12.5000% (minimum 60%, Enhanced); cerebral cortex: 20.0000% (minimum 60%, Enhanced); duodenum: 1.0000% (minimum 60%, Enhanced); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 25.0000% (minimum 75%, Missing); kidney: 50.0000% (minimum 60%, Enhanced); liver: 1.2048% (minimum 60%, Enhanced); pancreas: 4.1667% (minimum 60%, Enhanced); parathyroid gland: 11.1111% (minimum 55%, Enhanced); pituitary gland: 11.1111% (minimum 75%, Missing); retina: 1.8519% (minimum 75%, Missing); small intestine: 4.5455% (minimum 75%, Missing); stomach: 50.0000% (minimum 55%, Enhanced)",0.35,-0.438889,-0.731481,0,3,partial,9.9,0.8,0,"duodenum: 9.9 nTPM (vital, limit 6); liver: 8.2 nTPM (vital, limit 6); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Enhanced),52,not_established,required,in_situ_inflammation_review,gallbladder; gallbladder / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119547,ONECUT2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.0000% (minimum 60%, Enhanced); basal ganglia: 2.9412% (minimum 75%, Missing); cerebellum: 12.5000% (minimum 60%, Enhanced); cerebral cortex: 20.0000% (minimum 60%, Enhanced); duodenum: 1.0000% (minimum 60%, Enhanced); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 25.0000% (minimum 75%, Missing); kidney: 50.0000% (minimum 60%, Enhanced); liver: 1.2048% (minimum 60%, Enhanced); pancreas: 4.1667% (minimum 60%, Enhanced); parathyroid gland: 11.1111% (minimum 55%, Enhanced); pituitary gland: 11.1111% (minimum 75%, Missing); retina: 1.8519% (minimum 75%, Missing); small intestine: 4.5455% (minimum 75%, Missing); stomach: 50.0000% (minimum 55%, Enhanced)",0.35,-0.438889,-0.731481,0,3,partial,9.9,0.8,0,"duodenum: 9.9 nTPM (vital, limit 6); liver: 8.2 nTPM (vital, limit 6); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Enhanced),52,not_established,required,in_situ_inflammation_review,gallbladder; gallbladder / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119547,ONECUT2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.0000% (minimum 60%, Enhanced); basal ganglia: 2.9412% (minimum 75%, Missing); cerebellum: 12.5000% (minimum 60%, Enhanced); cerebral cortex: 20.0000% (minimum 60%, Enhanced); duodenum: 1.0000% (minimum 60%, Enhanced); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 25.0000% (minimum 75%, Missing); kidney: 50.0000% (minimum 60%, Enhanced); liver: 1.2048% (minimum 60%, Enhanced); pancreas: 4.1667% (minimum 60%, Enhanced); parathyroid gland: 11.1111% (minimum 55%, Enhanced); pituitary gland: 11.1111% (minimum 75%, Missing); retina: 1.8519% (minimum 75%, Missing); small intestine: 4.5455% (minimum 75%, Missing); stomach: 50.0000% (minimum 55%, Enhanced)",0.35,-0.438889,-0.731481,0,3,partial,9.9,0.8,0,"duodenum: 9.9 nTPM (vital, limit 6); liver: 8.2 nTPM (vital, limit 6); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Enhanced),52,not_established,required,in_situ_inflammation_review,gallbladder; gallbladder / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119547,ONECUT2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 2.9412% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 12.5000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 20.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 1.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 25.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 1.2048% (minimum 75%, Baseline (adaptation disabled)); pancreas: 4.1667% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 11.1111% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 11.1111% (minimum 75%, Baseline (adaptation disabled)); retina: 1.8519% (minimum 75%, Baseline (adaptation disabled)); small intestine: 4.5455% (minimum 75%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.588889,-0.74,0,3,partial,9.9,0.8,0,"duodenum: 9.9 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Enhanced),52,not_established,required,in_situ_inflammation_review,gallbladder; gallbladder / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119547,ONECUT2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.7345% (minimum 90%, Approved); adrenal gland: 48.5327% (minimum 98%, Approved); amygdala: 33.9652% (minimum 99%, Missing); basal ganglia: 37.0690% (minimum 99%, Missing); bone marrow: 73.6301% (minimum 98%, Approved); cerebellum: 43.1727% (minimum 98%, Approved); cerebral cortex: 33.6991% (minimum 98%, Approved); choroid plexus: 54.2929% (minimum 99%, Missing); colon: 55.2699% (minimum 97%, Missing); duodenum: 58.7432% (minimum 99%, Missing); esophagus: 52.0581% (minimum 97%, Missing); heart muscle: 51.0689% (minimum 99%, Missing); hippocampal formation: 35.1307% (minimum 99%, Missing); hypothalamus: 38.1206% (minimum 99%, Missing); kidney: 41.6667% (minimum 99%, Missing); liver: 42.8287% (minimum 99%, Missing); lung: 60.0559% (minimum 98%, Approved); lymph node: 59.7222% (minimum 95%, Approved); midbrain: 35.3038% (minimum 99%, Missing); pancreas: 52.5672% (minimum 98%, Approved); parathyroid gland: 58.9041% (minimum 97%, Missing); pituitary gland: 44.8852% (minimum 99%, Missing); rectum: 81.4394% (minimum 97%, Missing); retina: 76.2411% (minimum 99%, Missing); salivary gland: 55.6995% (minimum 97%, Missing); skeletal muscle: 57.9515% (minimum 98%, Approved); skin: 56.1358% (minimum 95%, Missing); small intestine: 55.5556% (minimum 99%, Missing); smooth muscle: 78.7546% (minimum 98%, Approved); spinal cord: 35.8932% (minimum 99%, Missing); spleen: 48.5327% (minimum 90%, Approved); stomach: 55.4124% (minimum 97%, Missing); thymus: 70.0326% (minimum 95%, Missing); thyroid gland: 48.2063% (minimum 95%, Missing); tongue: 74.9129% (minimum 97%, Missing); urinary bladder: 55.9896% (minimum 97%, Missing)",-0.467937,-0.449419,-0.650348,0,4,partial,42.3,19.8,23.1,"cerebral cortex: 42.3 nTPM (vital, limit 2); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 2); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (manageable, limit 5); spleen: 22.8 nTPM (manageable, limit 10); adrenal gland: 22.8 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 2); pancreas: 19.4 nTPM (vital, limit 2); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); stomach: 17.3 nTPM (protected, limit 2); small intestine: 17.2 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 2); urinary bladder: 16.9 nTPM (protected, limit 2); skin: 16.8 nTPM (manageable, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 2); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 2); lymph node: 14.5 nTPM (protected, limit 4); lung: 14.3 nTPM (vital, limit 2); adipose tissue: 13.9 nTPM (manageable, limit 10); thymus: 9.2 nTPM (manageable, limit 5); bone marrow: 7.7 nTPM (vital, limit 2); tongue: 7.2 nTPM (protected, limit 2); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 2); rectum: 4.9 nTPM (protected, limit 2)",bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119559,C19orf25,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.5327% (minimum 70%, Approved); amygdala: 33.9652% (minimum 75%, Missing); basal ganglia: 37.0690% (minimum 75%, Missing); cerebellum: 43.1727% (minimum 70%, Approved); cerebral cortex: 33.6991% (minimum 70%, Approved); choroid plexus: 54.2929% (minimum 75%, Missing); colon: 55.2699% (minimum 70%, Missing); duodenum: 58.7432% (minimum 75%, Missing); esophagus: 52.0581% (minimum 70%, Missing); heart muscle: 51.0689% (minimum 75%, Missing); hippocampal formation: 35.1307% (minimum 75%, Missing); hypothalamus: 38.1206% (minimum 75%, Missing); kidney: 41.6667% (minimum 75%, Missing); liver: 42.8287% (minimum 75%, Missing); lung: 60.0559% (minimum 70%, Approved); lymph node: 59.7222% (minimum 65%, Approved); midbrain: 35.3038% (minimum 75%, Missing); pancreas: 52.5672% (minimum 70%, Approved); parathyroid gland: 58.9041% (minimum 70%, Missing); pituitary gland: 44.8852% (minimum 75%, Missing); salivary gland: 55.6995% (minimum 70%, Missing); skeletal muscle: 57.9515% (minimum 70%, Approved); skin: 56.1358% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); spinal cord: 35.8932% (minimum 75%, Missing); spleen: 48.5327% (minimum 60%, Approved); stomach: 55.4124% (minimum 70%, Missing); thyroid gland: 48.2063% (minimum 65%, Missing); urinary bladder: 55.9896% (minimum 70%, Missing)",-0.167937,-0.179419,-0.410348,0,4,partial,42.3,19.8,23.1,"cerebral cortex: 42.3 nTPM (vital, limit 2); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 2); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (manageable, limit 5); spleen: 22.8 nTPM (manageable, limit 10); adrenal gland: 22.8 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 2); pancreas: 19.4 nTPM (vital, limit 2); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); stomach: 17.3 nTPM (protected, limit 2); small intestine: 17.2 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 2); urinary bladder: 16.9 nTPM (protected, limit 2); skin: 16.8 nTPM (manageable, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 2); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 2); lymph node: 14.5 nTPM (protected, limit 4); lung: 14.3 nTPM (vital, limit 2); adipose tissue: 13.9 nTPM (manageable, limit 10); thymus: 9.2 nTPM (manageable, limit 5); bone marrow: 7.7 nTPM (vital, limit 2); tongue: 7.2 nTPM (protected, limit 2); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 2); rectum: 4.9 nTPM (protected, limit 2)",bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119559,C19orf25,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.5327% (minimum 70%, Approved); amygdala: 33.9652% (minimum 75%, Missing); basal ganglia: 37.0690% (minimum 75%, Missing); cerebellum: 43.1727% (minimum 70%, Approved); cerebral cortex: 33.6991% (minimum 70%, Approved); choroid plexus: 54.2929% (minimum 75%, Missing); colon: 55.2699% (minimum 70%, Missing); duodenum: 58.7432% (minimum 75%, Missing); esophagus: 52.0581% (minimum 70%, Missing); heart muscle: 51.0689% (minimum 75%, Missing); hippocampal formation: 35.1307% (minimum 75%, Missing); hypothalamus: 38.1206% (minimum 75%, Missing); kidney: 41.6667% (minimum 75%, Missing); liver: 42.8287% (minimum 75%, Missing); lung: 60.0559% (minimum 70%, Approved); lymph node: 59.7222% (minimum 65%, Approved); midbrain: 35.3038% (minimum 75%, Missing); pancreas: 52.5672% (minimum 70%, Approved); parathyroid gland: 58.9041% (minimum 70%, Missing); pituitary gland: 44.8852% (minimum 75%, Missing); salivary gland: 55.6995% (minimum 70%, Missing); skeletal muscle: 57.9515% (minimum 70%, Approved); skin: 56.1358% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); spinal cord: 35.8932% (minimum 75%, Missing); spleen: 48.5327% (minimum 60%, Approved); stomach: 55.4124% (minimum 70%, Missing); thyroid gland: 48.2063% (minimum 65%, Missing); urinary bladder: 55.9896% (minimum 70%, Missing)",-0.167937,-0.179419,-0.410348,0,4,partial,42.3,19.8,23.1,"cerebral cortex: 42.3 nTPM (vital, limit 2); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 2); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (manageable, limit 5); spleen: 22.8 nTPM (manageable, limit 10); adrenal gland: 22.8 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 3); pancreas: 19.4 nTPM (vital, limit 2); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); stomach: 17.3 nTPM (protected, limit 3); small intestine: 17.2 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 3); urinary bladder: 16.9 nTPM (protected, limit 3); skin: 16.8 nTPM (manageable, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 2); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 3); lymph node: 14.5 nTPM (protected, limit 4); lung: 14.3 nTPM (vital, limit 2); adipose tissue: 13.9 nTPM (manageable, limit 10); thymus: 9.2 nTPM (manageable, limit 5); bone marrow: 7.7 nTPM (vital, limit 2); tongue: 7.2 nTPM (protected, limit 3); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 2); rectum: 4.9 nTPM (protected, limit 3)",bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119559,C19orf25,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.5327% (minimum 70%, Approved); amygdala: 33.9652% (minimum 75%, Missing); basal ganglia: 37.0690% (minimum 75%, Missing); cerebellum: 43.1727% (minimum 70%, Approved); cerebral cortex: 33.6991% (minimum 70%, Approved); choroid plexus: 54.2929% (minimum 75%, Missing); colon: 55.2699% (minimum 70%, Missing); duodenum: 58.7432% (minimum 75%, Missing); esophagus: 52.0581% (minimum 70%, Missing); heart muscle: 51.0689% (minimum 75%, Missing); hippocampal formation: 35.1307% (minimum 75%, Missing); hypothalamus: 38.1206% (minimum 75%, Missing); kidney: 41.6667% (minimum 75%, Missing); liver: 42.8287% (minimum 75%, Missing); lung: 60.0559% (minimum 70%, Approved); lymph node: 59.7222% (minimum 65%, Approved); midbrain: 35.3038% (minimum 75%, Missing); pancreas: 52.5672% (minimum 70%, Approved); parathyroid gland: 58.9041% (minimum 70%, Missing); pituitary gland: 44.8852% (minimum 75%, Missing); salivary gland: 55.6995% (minimum 70%, Missing); skeletal muscle: 57.9515% (minimum 70%, Approved); skin: 56.1358% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); spinal cord: 35.8932% (minimum 75%, Missing); spleen: 48.5327% (minimum 60%, Approved); stomach: 55.4124% (minimum 70%, Missing); thyroid gland: 48.2063% (minimum 65%, Missing); urinary bladder: 55.9896% (minimum 70%, Missing)",-0.167937,-0.179419,-0.410348,0,4,partial,42.3,19.8,23.1,"cerebral cortex: 42.3 nTPM (vital, limit 2); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 2); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (manageable, limit 5); spleen: 22.8 nTPM (manageable, limit 10); adrenal gland: 22.8 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 3); pancreas: 19.4 nTPM (vital, limit 2); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); stomach: 17.3 nTPM (protected, limit 3); small intestine: 17.2 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 3); urinary bladder: 16.9 nTPM (protected, limit 3); skin: 16.8 nTPM (manageable, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 2); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 3); lymph node: 14.5 nTPM (protected, limit 4); lung: 14.3 nTPM (vital, limit 2); adipose tissue: 13.9 nTPM (manageable, limit 10); thymus: 9.2 nTPM (manageable, limit 5); bone marrow: 7.7 nTPM (vital, limit 2); tongue: 7.2 nTPM (protected, limit 3); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 2); rectum: 4.9 nTPM (protected, limit 3)",bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119559,C19orf25,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.7345% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 48.5327% (minimum 75%, Baseline (adaptation disabled)); amygdala: 33.9652% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 37.0690% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 73.6301% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.1727% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 33.6991% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 54.2929% (minimum 75%, Baseline (adaptation disabled)); colon: 55.2699% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.7432% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.0581% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 51.0689% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 35.1307% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 38.1206% (minimum 75%, Baseline (adaptation disabled)); kidney: 41.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 42.8287% (minimum 75%, Baseline (adaptation disabled)); lung: 60.0559% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.7222% (minimum 70%, Baseline (adaptation disabled)); midbrain: 35.3038% (minimum 75%, Baseline (adaptation disabled)); pancreas: 52.5672% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.9041% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 44.8852% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.6995% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 57.9515% (minimum 75%, Baseline (adaptation disabled)); skin: 56.1358% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.5556% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 35.8932% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.5327% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.4124% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 48.2063% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 55.9896% (minimum 70%, Baseline (adaptation disabled))",-0.167937,-0.179419,-0.413009,0,4,partial,42.3,19.8,23.1,"cerebral cortex: 42.3 nTPM (vital, limit 1); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 1); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (manageable, limit 5); spleen: 22.8 nTPM (manageable, limit 5); adrenal gland: 22.8 nTPM (vital, limit 1); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 3); pancreas: 19.4 nTPM (vital, limit 1); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); stomach: 17.3 nTPM (protected, limit 3); small intestine: 17.2 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 3); urinary bladder: 16.9 nTPM (protected, limit 3); skin: 16.8 nTPM (manageable, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 1); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 3); lymph node: 14.5 nTPM (protected, limit 3); lung: 14.3 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); bone marrow: 7.7 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 3); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 3)",bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119559,C19orf25,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 88.1864% (minimum 95%, Missing); adrenal gland: 89.8305% (minimum 98%, Approved); amygdala: 88.4808% (minimum 99%, Missing); basal ganglia: 87.7483% (minimum 99%, Missing); bone marrow: 91.2220% (minimum 99%, Missing); cerebellum: 91.2220% (minimum 98%, Approved); cerebral cortex: 82.8125% (minimum 99%, Missing); choroid plexus: 77.8267% (minimum 99%, Missing); colon: 92.1739% (minimum 95%, Approved); duodenum: 95.3237% (minimum 98%, Approved); esophagus: 92.6573% (minimum 95%, Approved); heart muscle: 85.8995% (minimum 99%, Missing); hippocampal formation: 87.7483% (minimum 99%, Missing); hypothalamus: 87.7483% (minimum 99%, Missing); kidney: 83.0721% (minimum 99%, Missing); liver: 93.8053% (minimum 99%, Missing); lung: 88.1864% (minimum 98%, Approved); lymph node: 91.8544% (minimum 97%, Missing); midbrain: 90.1361% (minimum 99%, Missing); pancreas: 90.5983% (minimum 99%, Missing); parathyroid gland: 79.1045% (minimum 97%, Missing); pituitary gland: 86.6013% (minimum 99%, Missing); rectum: 91.3793% (minimum 97%, Missing); retina: 75.3912% (minimum 99%, Missing); salivary gland: 92.4956% (minimum 97%, Missing); skeletal muscle: 91.6955% (minimum 98%, Approved); small intestine: 94.9821% (minimum 98%, Approved); smooth muscle: 85.6220% (minimum 98%, Approved); spinal cord: 91.8544% (minimum 99%, Missing); stomach: 90.7534% (minimum 97%, Missing); thymus: 90.1361% (minimum 95%, Missing); thyroid gland: 77.2595% (minimum 95%, Missing); tongue: 90.2896% (minimum 97%, Missing); urinary bladder: 89.9830% (minimum 97%, Missing)",-0.177405,-0.178955,-0.236088,0,6,partial,17.3,14,15.6,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (manageable, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 2); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); pituitary gland: 8.2 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7.1 nTPM (vital, limit 2); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 2); urinary bladder: 5.9 nTPM (protected, limit 2); thymus: 5.8 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); cerebellum: 5.1 nTPM (vital, limit 2); bone marrow: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 2); spinal cord: 4.7 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 4); salivary gland: 4.3 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 4); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119661,DNAL1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.122595,0.0910448,0.00391181,0,6,partial,17.3,14,15.6,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (manageable, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 2); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); pituitary gland: 8.2 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7.1 nTPM (vital, limit 2); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 2); urinary bladder: 5.9 nTPM (protected, limit 2); thymus: 5.8 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); cerebellum: 5.1 nTPM (vital, limit 2); bone marrow: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 2); spinal cord: 4.7 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 4); salivary gland: 4.3 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 4); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119661,DNAL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.122595,0.0910448,0.00391181,0,6,partial,17.3,14,15.6,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (manageable, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 3); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); pituitary gland: 8.2 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7.1 nTPM (vital, limit 2); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 2); urinary bladder: 5.9 nTPM (protected, limit 3); thymus: 5.8 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); cerebellum: 5.1 nTPM (vital, limit 2); bone marrow: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 2); spinal cord: 4.7 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 4); salivary gland: 4.3 nTPM (protected, limit 3); esophagus: 4.2 nTPM (protected, limit 4); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119661,DNAL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.122595,0.0910448,0.00391181,0,6,partial,17.3,14,15.6,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (manageable, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 3); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); pituitary gland: 8.2 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7.1 nTPM (vital, limit 2); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 2); urinary bladder: 5.9 nTPM (protected, limit 3); thymus: 5.8 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); cerebellum: 5.1 nTPM (vital, limit 2); bone marrow: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 2); spinal cord: 4.7 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 4); salivary gland: 4.3 nTPM (protected, limit 3); esophagus: 4.2 nTPM (protected, limit 4); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119661,DNAL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.122595,0.0910448,0.00391181,0,6,partial,17.3,14,15.6,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (manageable, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 3); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); heart muscle: 8.7 nTPM (vital, limit 1); pituitary gland: 8.2 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7.1 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 3); thymus: 5.8 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); cerebellum: 5.1 nTPM (vital, limit 1); bone marrow: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3); salivary gland: 4.3 nTPM (protected, limit 3); esophagus: 4.2 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119661,DNAL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.0442% (minimum 99%, Missing); basal ganglia: 92.5862% (minimum 99%, Missing); cerebellum: 97.4592% (minimum 99%, Missing); cerebral cortex: 94.5423% (minimum 99%, Missing); choroid plexus: 86.3344% (minimum 99%, Missing); colon: 95.3819% (minimum 97%, Missing); duodenum: 94.7090% (minimum 95%, Enhanced); heart muscle: 91.3265% (minimum 95%, Enhanced); hippocampal formation: 94.8763% (minimum 99%, Missing); hypothalamus: 93.3913% (minimum 99%, Missing); kidney: 91.0169% (minimum 95%, Enhanced); liver: 86.7528% (minimum 95%, Enhanced); midbrain: 94.2105% (minimum 99%, Missing); pancreas: 91.4821% (minimum 95%, Enhanced); pituitary gland: 89.9497% (minimum 99%, Missing); retina: 95.5516% (minimum 99%, Missing); skeletal muscle: 92.2680% (minimum 95%, Enhanced); smooth muscle: 98.3516% (minimum 99%, Missing); spinal cord: 95.7219% (minimum 99%, Missing)",0.010644,-0.0161812,-0.126656,0,6,partial,8.5,6.7,6.8,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 6); pituitary gland: 6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119703,ZC2HC1C,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.310644,0.253819,0.113344,0,6,partial,8.5,6.7,6.8,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 6); pituitary gland: 6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119703,ZC2HC1C,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.310644,0.253819,0.113344,0,6,partial,8.5,6.7,6.8,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 6); pituitary gland: 6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119703,ZC2HC1C,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.310644,0.253819,0.113344,0,6,partial,8.5,6.7,6.8,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 6); pituitary gland: 6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119703,ZC2HC1C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.237603,0.189073,0.113344,0,6,partial,8.5,6.7,6.8,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); parathyroid gland: 6.7 nTPM (protected, limit 3); pituitary gland: 6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119703,ZC2HC1C,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9484% (minimum 95%, Missing); adrenal gland: 57.7279% (minimum 99%, Missing); amygdala: 71.9934% (minimum 99%, Missing); basal ganglia: 71.8750% (minimum 99%, Missing); bone marrow: 43.3962% (minimum 99%, Missing); cerebellum: 72.1122% (minimum 99%, Missing); cerebral cortex: 71.9934% (minimum 99%, Missing); choroid plexus: 58.7366% (minimum 99%, Missing); colon: 59.6995% (minimum 97%, Missing); duodenum: 70.2572% (minimum 99%, Missing); esophagus: 57.4244% (minimum 97%, Missing); heart muscle: 68.3881% (minimum 99%, Missing); hippocampal formation: 73.3221% (minimum 99%, Missing); hypothalamus: 73.4454% (minimum 99%, Missing); kidney: 57.7279% (minimum 99%, Missing); liver: 60.9484% (minimum 99%, Missing); lung: 62.0739% (minimum 99%, Missing); lymph node: 63.5174% (minimum 97%, Missing); midbrain: 71.1726% (minimum 99%, Missing); pancreas: 68.6028% (minimum 99%, Missing); parathyroid gland: 62.6973% (minimum 97%, Missing); pituitary gland: 62.5179% (minimum 99%, Missing); rectum: 65.1267% (minimum 97%, Missing); retina: 66.5145% (minimum 99%, Missing); salivary gland: 64.8368% (minimum 97%, Missing); skeletal muscle: 68.2812% (minimum 99%, Missing); skin: 54.5568% (minimum 95%, Missing); small intestine: 64.0762% (minimum 99%, Missing); smooth muscle: 62.0739% (minimum 99%, Missing); spinal cord: 70.4839% (minimum 99%, Missing); spleen: 63.1503% (minimum 95%, Missing); stomach: 63.7026% (minimum 97%, Missing); thymus: 60.1928% (minimum 95%, Missing); thyroid gland: 64.7407% (minimum 95%, Missing); tongue: 71.1726% (minimum 97%, Missing); urinary bladder: 60.8635% (minimum 97%, Missing)",-0.404432,-0.395756,-0.556038,0,80,unavailable,57,32.4,36.4,"bone marrow: 57 nTPM (vital, limit 1); skin: 36.4 nTPM (manageable, limit 5); esophagus: 32.4 nTPM (protected, limit 2); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 2); thymus: 28.9 nTPM (manageable, limit 5); urinary bladder: 28.1 nTPM (protected, limit 2); liver: 28 nTPM (vital, limit 1); adipose tissue: 28 nTPM (manageable, limit 5); lung: 26.7 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 2); spleen: 25.5 nTPM (manageable, limit 5); lymph node: 25.1 nTPM (protected, limit 2); stomach: 24.9 nTPM (protected, limit 2); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (manageable, limit 5); salivary gland: 23.7 nTPM (protected, limit 2); rectum: 23.4 nTPM (protected, limit 2); retina: 22 nTPM (vital, limit 1); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); spinal cord: 18.3 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 2); midbrain: 17.7 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119725,ZNF410,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9484% (minimum 65%, Missing); adrenal gland: 57.7279% (minimum 75%, Missing); amygdala: 71.9934% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); bone marrow: 43.3962% (minimum 75%, Missing); cerebellum: 72.1122% (minimum 75%, Missing); cerebral cortex: 71.9934% (minimum 75%, Missing); choroid plexus: 58.7366% (minimum 75%, Missing); colon: 59.6995% (minimum 70%, Missing); duodenum: 70.2572% (minimum 75%, Missing); esophagus: 57.4244% (minimum 70%, Missing); heart muscle: 68.3881% (minimum 75%, Missing); hippocampal formation: 73.3221% (minimum 75%, Missing); hypothalamus: 73.4454% (minimum 75%, Missing); kidney: 57.7279% (minimum 75%, Missing); liver: 60.9484% (minimum 75%, Missing); lung: 62.0739% (minimum 75%, Missing); lymph node: 63.5174% (minimum 70%, Missing); midbrain: 71.1726% (minimum 75%, Missing); pancreas: 68.6028% (minimum 75%, Missing); parathyroid gland: 62.6973% (minimum 70%, Missing); pituitary gland: 62.5179% (minimum 75%, Missing); rectum: 65.1267% (minimum 70%, Missing); retina: 66.5145% (minimum 75%, Missing); salivary gland: 64.8368% (minimum 70%, Missing); skeletal muscle: 68.2812% (minimum 75%, Missing); skin: 54.5568% (minimum 65%, Missing); small intestine: 64.0762% (minimum 75%, Missing); smooth muscle: 62.0739% (minimum 75%, Missing); spinal cord: 70.4839% (minimum 75%, Missing); spleen: 63.1503% (minimum 65%, Missing); stomach: 63.7026% (minimum 70%, Missing); thymus: 60.1928% (minimum 65%, Missing); thyroid gland: 64.7407% (minimum 65%, Missing); urinary bladder: 60.8635% (minimum 70%, Missing)",-0.104432,-0.125756,-0.316038,0,80,unavailable,57,32.4,36.4,"bone marrow: 57 nTPM (vital, limit 1); skin: 36.4 nTPM (manageable, limit 5); esophagus: 32.4 nTPM (protected, limit 2); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 2); thymus: 28.9 nTPM (manageable, limit 5); urinary bladder: 28.1 nTPM (protected, limit 2); liver: 28 nTPM (vital, limit 1); adipose tissue: 28 nTPM (manageable, limit 5); lung: 26.7 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 2); spleen: 25.5 nTPM (manageable, limit 5); lymph node: 25.1 nTPM (protected, limit 2); stomach: 24.9 nTPM (protected, limit 2); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (manageable, limit 5); salivary gland: 23.7 nTPM (protected, limit 2); rectum: 23.4 nTPM (protected, limit 2); retina: 22 nTPM (vital, limit 1); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); spinal cord: 18.3 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 2); midbrain: 17.7 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119725,ZNF410,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9484% (minimum 65%, Missing); adrenal gland: 57.7279% (minimum 75%, Missing); amygdala: 71.9934% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); bone marrow: 43.3962% (minimum 75%, Missing); cerebellum: 72.1122% (minimum 75%, Missing); cerebral cortex: 71.9934% (minimum 75%, Missing); choroid plexus: 58.7366% (minimum 75%, Missing); colon: 59.6995% (minimum 70%, Missing); duodenum: 70.2572% (minimum 75%, Missing); esophagus: 57.4244% (minimum 70%, Missing); heart muscle: 68.3881% (minimum 75%, Missing); hippocampal formation: 73.3221% (minimum 75%, Missing); hypothalamus: 73.4454% (minimum 75%, Missing); kidney: 57.7279% (minimum 75%, Missing); liver: 60.9484% (minimum 75%, Missing); lung: 62.0739% (minimum 75%, Missing); lymph node: 63.5174% (minimum 70%, Missing); midbrain: 71.1726% (minimum 75%, Missing); pancreas: 68.6028% (minimum 75%, Missing); parathyroid gland: 62.6973% (minimum 70%, Missing); pituitary gland: 62.5179% (minimum 75%, Missing); rectum: 65.1267% (minimum 70%, Missing); retina: 66.5145% (minimum 75%, Missing); salivary gland: 64.8368% (minimum 70%, Missing); skeletal muscle: 68.2812% (minimum 75%, Missing); skin: 54.5568% (minimum 65%, Missing); small intestine: 64.0762% (minimum 75%, Missing); smooth muscle: 62.0739% (minimum 75%, Missing); spinal cord: 70.4839% (minimum 75%, Missing); spleen: 63.1503% (minimum 65%, Missing); stomach: 63.7026% (minimum 70%, Missing); thymus: 60.1928% (minimum 65%, Missing); thyroid gland: 64.7407% (minimum 65%, Missing); urinary bladder: 60.8635% (minimum 70%, Missing)",-0.104432,-0.125756,-0.316038,0,80,unavailable,57,32.4,36.4,"bone marrow: 57 nTPM (vital, limit 1); skin: 36.4 nTPM (manageable, limit 5); esophagus: 32.4 nTPM (protected, limit 3); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 3); thymus: 28.9 nTPM (manageable, limit 5); urinary bladder: 28.1 nTPM (protected, limit 3); liver: 28 nTPM (vital, limit 1); adipose tissue: 28 nTPM (manageable, limit 5); lung: 26.7 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 3); spleen: 25.5 nTPM (manageable, limit 5); lymph node: 25.1 nTPM (protected, limit 3); stomach: 24.9 nTPM (protected, limit 3); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (manageable, limit 5); salivary gland: 23.7 nTPM (protected, limit 3); rectum: 23.4 nTPM (protected, limit 3); retina: 22 nTPM (vital, limit 1); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); spinal cord: 18.3 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 3); midbrain: 17.7 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119725,ZNF410,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9484% (minimum 65%, Missing); adrenal gland: 57.7279% (minimum 75%, Missing); amygdala: 71.9934% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); bone marrow: 43.3962% (minimum 75%, Missing); cerebellum: 72.1122% (minimum 75%, Missing); cerebral cortex: 71.9934% (minimum 75%, Missing); choroid plexus: 58.7366% (minimum 75%, Missing); colon: 59.6995% (minimum 70%, Missing); duodenum: 70.2572% (minimum 75%, Missing); esophagus: 57.4244% (minimum 70%, Missing); heart muscle: 68.3881% (minimum 75%, Missing); hippocampal formation: 73.3221% (minimum 75%, Missing); hypothalamus: 73.4454% (minimum 75%, Missing); kidney: 57.7279% (minimum 75%, Missing); liver: 60.9484% (minimum 75%, Missing); lung: 62.0739% (minimum 75%, Missing); lymph node: 63.5174% (minimum 70%, Missing); midbrain: 71.1726% (minimum 75%, Missing); pancreas: 68.6028% (minimum 75%, Missing); parathyroid gland: 62.6973% (minimum 70%, Missing); pituitary gland: 62.5179% (minimum 75%, Missing); rectum: 65.1267% (minimum 70%, Missing); retina: 66.5145% (minimum 75%, Missing); salivary gland: 64.8368% (minimum 70%, Missing); skeletal muscle: 68.2812% (minimum 75%, Missing); skin: 54.5568% (minimum 65%, Missing); small intestine: 64.0762% (minimum 75%, Missing); smooth muscle: 62.0739% (minimum 75%, Missing); spinal cord: 70.4839% (minimum 75%, Missing); spleen: 63.1503% (minimum 65%, Missing); stomach: 63.7026% (minimum 70%, Missing); thymus: 60.1928% (minimum 65%, Missing); thyroid gland: 64.7407% (minimum 65%, Missing); urinary bladder: 60.8635% (minimum 70%, Missing)",-0.104432,-0.125756,-0.316038,0,80,unavailable,57,32.4,36.4,"bone marrow: 57 nTPM (vital, limit 1); skin: 36.4 nTPM (manageable, limit 5); esophagus: 32.4 nTPM (protected, limit 3); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 3); thymus: 28.9 nTPM (manageable, limit 5); urinary bladder: 28.1 nTPM (protected, limit 3); liver: 28 nTPM (vital, limit 1); adipose tissue: 28 nTPM (manageable, limit 5); lung: 26.7 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 3); spleen: 25.5 nTPM (manageable, limit 5); lymph node: 25.1 nTPM (protected, limit 3); stomach: 24.9 nTPM (protected, limit 3); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (manageable, limit 5); salivary gland: 23.7 nTPM (protected, limit 3); rectum: 23.4 nTPM (protected, limit 3); retina: 22 nTPM (vital, limit 1); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); spinal cord: 18.3 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 3); midbrain: 17.7 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119725,ZNF410,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9484% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 57.7279% (minimum 75%, Baseline (adaptation disabled)); amygdala: 71.9934% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.8750% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 43.3962% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.1122% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 71.9934% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.7366% (minimum 75%, Baseline (adaptation disabled)); colon: 59.6995% (minimum 70%, Baseline (adaptation disabled)); duodenum: 70.2572% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.4244% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.3881% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.3221% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.4454% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.7279% (minimum 75%, Baseline (adaptation disabled)); liver: 60.9484% (minimum 75%, Baseline (adaptation disabled)); lung: 62.0739% (minimum 75%, Baseline (adaptation disabled)); lymph node: 63.5174% (minimum 70%, Baseline (adaptation disabled)); midbrain: 71.1726% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.6028% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.6973% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.5179% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.1267% (minimum 70%, Baseline (adaptation disabled)); retina: 66.5145% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.8368% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 68.2812% (minimum 75%, Baseline (adaptation disabled)); skin: 54.5568% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.0762% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.0739% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.4839% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.1503% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.7026% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.1928% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 64.7407% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 60.8635% (minimum 70%, Baseline (adaptation disabled))",-0.104432,-0.125756,-0.316038,0,80,unavailable,57,32.4,36.4,"bone marrow: 57 nTPM (vital, limit 1); skin: 36.4 nTPM (manageable, limit 5); esophagus: 32.4 nTPM (protected, limit 3); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 3); thymus: 28.9 nTPM (manageable, limit 5); urinary bladder: 28.1 nTPM (protected, limit 3); liver: 28 nTPM (vital, limit 1); adipose tissue: 28 nTPM (manageable, limit 5); lung: 26.7 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 3); spleen: 25.5 nTPM (manageable, limit 5); lymph node: 25.1 nTPM (protected, limit 3); stomach: 24.9 nTPM (protected, limit 3); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (manageable, limit 5); salivary gland: 23.7 nTPM (protected, limit 3); rectum: 23.4 nTPM (protected, limit 3); retina: 22 nTPM (vital, limit 1); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); spinal cord: 18.3 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 3); midbrain: 17.7 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000119725,ZNF410,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5882% (minimum 98%, Approved); amygdala: 95.5882% (minimum 99%, Missing); basal ganglia: 91.5493% (minimum 99%, Missing); bone marrow: 97.0149% (minimum 98%, Approved); cerebral cortex: 96.2963% (minimum 98%, Approved); choroid plexus: 80.2469% (minimum 99%, Missing); heart muscle: 83.8710% (minimum 98%, Approved); hippocampal formation: 92.8571% (minimum 99%, Missing); hypothalamus: 91.5493% (minimum 99%, Missing); kidney: 94.8905% (minimum 98%, Approved); lung: 90.9091% (minimum 98%, Approved); midbrain: 97.0149% (minimum 99%, Missing); pancreas: 97.7444% (minimum 98%, Approved); pituitary gland: 90.2778% (minimum 99%, Missing); retina: 96.2963% (minimum 99%, Missing); skeletal muscle: 91.5493% (minimum 98%, Approved); smooth muscle: 95.5882% (minimum 98%, Approved); spinal cord: 97.7444% (minimum 99%, Missing); tongue: 94.8905% (minimum 97%, Missing)",0.0423664,-0.0210949,-0.187531,0,2,partial,3.2,0.7,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120051,CFAP58,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342366,0.248905,0.0524691,0,2,partial,3.2,0.7,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120051,CFAP58,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342366,0.248905,0.0524691,0,2,partial,3.2,0.7,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120051,CFAP58,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342366,0.248905,0.0524691,0,2,partial,3.2,0.7,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120051,CFAP58,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.298905,0.248905,0.0524691,0,2,partial,3.2,0.7,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120051,CFAP58,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.6559% (minimum 99%, Missing); spinal cord: 98.3914% (minimum 99%, Missing)",0.05,0.0272826,-0.00608579,0,2,partial,0.6,0.3,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120160,EQTN,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.297283,0.233914,0,2,partial,0.6,0.3,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120160,EQTN,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.297283,0.233914,0,2,partial,0.6,0.3,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120160,EQTN,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.297283,0.233914,0,2,partial,0.6,0.3,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120160,EQTN,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34458,0.291892,0.233914,0,2,partial,0.6,0.3,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120160,EQTN,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.1392% (minimum 95%, Enhanced); retina: 69.2308% (minimum 99%, Missing)",0.05,0.03,-0.297692,0,4,partial,6.4,1,1.1,"retina: 6.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120210,INSL6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 75%, Missing)",0.35,0.3,-0.0576923,0,4,partial,6.4,1,1.1,"retina: 6.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120210,INSL6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 75%, Missing)",0.35,0.3,-0.0576923,0,4,partial,6.4,1,1.1,"retina: 6.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120210,INSL6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 75%, Missing)",0.35,0.3,-0.0576923,0,4,partial,6.4,1,1.1,"retina: 6.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120210,INSL6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 75%, Baseline (adaptation disabled))",0.279032,0.235065,-0.0576923,0,4,partial,6.4,1,1.1,"retina: 6.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120210,INSL6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.0892% (minimum 99%, Missing)",0.0371795,0.0235484,-0.00910828,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120211,INSL4,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.337179,0.293548,0.230892,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120211,INSL4,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.337179,0.293548,0.230892,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120211,INSL4,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.337179,0.293548,0.230892,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120211,INSL4,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.337179,0.293548,0.230892,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120211,INSL4,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 86.6667% (minimum 95%, Enhanced); bone marrow: 65.0000% (minimum 95%, Enhanced); cerebellum: 92.8571% (minimum 95%, Enhanced); cerebral cortex: 92.8571% (minimum 95%, Enhanced); duodenum: 92.8571% (minimum 95%, Enhanced); heart muscle: 92.8571% (minimum 95%, Enhanced); kidney: 81.2500% (minimum 95%, Enhanced); liver: 76.4706% (minimum 95%, Enhanced); lung: 92.8571% (minimum 95%, Enhanced); lymph node: 76.4706% (minimum 80%, Enhanced); pancreas: 92.8571% (minimum 95%, Enhanced); pituitary gland: 92.8571% (minimum 99%, Missing); retina: 81.2500% (minimum 99%, Missing); salivary gland: 56.5217% (minimum 80%, Enhanced); skeletal muscle: 86.6667% (minimum 95%, Enhanced); skin: 3.0162% (minimum 95%, Missing); small intestine: 92.8571% (minimum 95%, Enhanced); spinal cord: 76.4706% (minimum 99%, Missing); thymus: 92.8571% (minimum 95%, Missing)",-0.919838,-0.234783,-0.3,0,6,partial,0.7,1,41.8,"skin: 41.8 nTPM (manageable, limit 5)",retina / pigment epithelial cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120215,MLANA,admission_only,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 3.0162% (minimum 65%, Missing)",-0.619838,0.0152174,0.0147059,0,6,partial,0.7,1,41.8,"skin: 41.8 nTPM (manageable, limit 5)",retina / pigment epithelial cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120215,MLANA,selectivity_revised,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 3.0162% (minimum 65%, Missing)",-0.619838,0.0152174,0.0147059,0,6,partial,0.7,1,41.8,"skin: 41.8 nTPM (manageable, limit 5)",retina / pigment epithelial cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120215,MLANA,grid_revised,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 3.0162% (minimum 65%, Missing)",-0.619838,0.0152174,0.0147059,0,6,partial,0.7,1,41.8,"skin: 41.8 nTPM (manageable, limit 5)",retina / pigment epithelial cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120215,MLANA,current_adaptive,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 65.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.5217% (minimum 70%, Baseline (adaptation disabled)); skin: 3.0162% (minimum 65%, Baseline (adaptation disabled))",-0.619838,-0.134783,-0.1,0,6,partial,0.7,1,41.8,"skin: 41.8 nTPM (manageable, limit 5)",retina / pigment epithelial cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120215,MLANA,current_fixed,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 89.0110% (minimum 95%, Enhanced); amygdala: 97.5904% (minimum 99%, Missing); basal ganglia: 95.8580% (minimum 99%, Missing); choroid plexus: 73.9726% (minimum 99%, Missing); duodenum: 92.8367% (minimum 95%, Enhanced); hippocampal formation: 96.1424% (minimum 99%, Missing); hypothalamus: 95.2941% (minimum 99%, Missing); lung: 89.0110% (minimum 95%, Enhanced); midbrain: 97.8852% (minimum 99%, Missing); smooth muscle: 97.2973% (minimum 99%, Missing); spinal cord: 98.7805% (minimum 99%, Missing); thyroid gland: 85.7143% (minimum 95%, Missing)",-0.0928571,0.0269231,-0.250274,0,7,partial,11.4,1.6,5.4,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120262,CCDC170,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 73.9726% (minimum 75%, Missing)",0.207143,0.296923,-0.010274,0,7,partial,11.4,1.6,5.4,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120262,CCDC170,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 73.9726% (minimum 75%, Missing)",0.207143,0.296923,-0.010274,0,7,partial,11.4,1.6,5.4,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120262,CCDC170,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 73.9726% (minimum 75%, Missing)",0.207143,0.296923,-0.010274,0,7,partial,11.4,1.6,5.4,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120262,CCDC170,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 73.9726% (minimum 75%, Baseline (adaptation disabled))",0.207143,0.252941,-0.010274,0,7,partial,11.4,1.6,5.4,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); adrenal gland: 4 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120262,CCDC170,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120289,MAGEB4,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120289,MAGEB4,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120289,MAGEB4,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120289,MAGEB4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120289,MAGEB4,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.4615% (minimum 99%, Missing); kidney: 98.4615% (minimum 99%, Missing); liver: 96.9697% (minimum 99%, Missing); lung: 98.4615% (minimum 99%, Missing); pancreas: 98.4615% (minimum 99%, Missing); pituitary gland: 96.9697% (minimum 99%, Missing)",0.019697,0.0146154,-0.020303,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120329,SLC25A2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.319697,0.284615,0.219697,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120329,SLC25A2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.319697,0.284615,0.219697,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120329,SLC25A2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.319697,0.284615,0.219697,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120329,SLC25A2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.319697,0.284615,0.219697,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120329,SLC25A2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4561% (minimum 95%, Missing); adrenal gland: 88.6792% (minimum 99%, Missing); amygdala: 89.5238% (minimum 99%, Missing); basal ganglia: 89.5238% (minimum 99%, Missing); bone marrow: 50.2674% (minimum 99%, Missing); cerebellum: 92.1569% (minimum 99%, Missing); cerebral cortex: 87.0370% (minimum 99%, Missing); choroid plexus: 92.1569% (minimum 99%, Missing); colon: 80.3419% (minimum 97%, Missing); duodenum: 81.7391% (minimum 99%, Missing); esophagus: 81.0345% (minimum 97%, Missing); heart muscle: 85.4545% (minimum 99%, Missing); hippocampal formation: 90.3846% (minimum 99%, Missing); hypothalamus: 89.5238% (minimum 99%, Missing); kidney: 87.0370% (minimum 99%, Missing); liver: 91.2621% (minimum 99%, Missing); lung: 87.8505% (minimum 99%, Missing); lymph node: 59.8726% (minimum 97%, Missing); midbrain: 89.5238% (minimum 99%, Missing); pancreas: 93.0693% (minimum 99%, Missing); parathyroid gland: 89.5238% (minimum 97%, Uncertain); pituitary gland: 94.0000% (minimum 99%, Missing); rectum: 77.0492% (minimum 97%, Missing); retina: 86.2385% (minimum 99%, Missing); salivary gland: 87.8505% (minimum 97%, Missing); skeletal muscle: 87.0370% (minimum 99%, Missing); skin: 81.7391% (minimum 95%, Missing); small intestine: 84.6847% (minimum 99%, Missing); smooth muscle: 81.0345% (minimum 99%, Missing); spinal cord: 87.8505% (minimum 99%, Missing); spleen: 81.7391% (minimum 95%, Uncertain); stomach: 81.7391% (minimum 97%, Missing); thymus: 52.5140% (minimum 95%, Missing); thyroid gland: 85.4545% (minimum 95%, Missing); tongue: 81.7391% (minimum 97%, Missing); urinary bladder: 83.9286% (minimum 97%, Missing)",-0.42486,-0.371274,-0.487326,0,2,partial,9.3,6.3,8.5,"bone marrow: 9.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 2); rectum: 2.8 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); duodenum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120334,CENPL,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 50.2674% (minimum 75%, Missing); lymph node: 59.8726% (minimum 70%, Missing); thymus: 52.5140% (minimum 65%, Missing)",-0.12486,-0.101274,-0.247326,0,2,partial,9.3,6.3,8.5,"bone marrow: 9.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 2); rectum: 2.8 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); duodenum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120334,CENPL,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 50.2674% (minimum 75%, Missing); lymph node: 59.8726% (minimum 70%, Missing); thymus: 52.5140% (minimum 65%, Missing)",-0.12486,-0.101274,-0.247326,0,2,partial,9.3,6.3,8.5,"bone marrow: 9.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 3); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120334,CENPL,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 50.2674% (minimum 75%, Missing); lymph node: 59.8726% (minimum 70%, Missing); thymus: 52.5140% (minimum 65%, Missing)",-0.12486,-0.101274,-0.247326,0,2,partial,9.3,6.3,8.5,"bone marrow: 9.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 3); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120334,CENPL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 50.2674% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.8726% (minimum 70%, Baseline (adaptation disabled)); thymus: 52.5140% (minimum 65%, Baseline (adaptation disabled))",-0.12486,-0.101274,-0.247326,0,2,partial,9.3,6.3,8.5,"bone marrow: 9.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 3); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120334,CENPL,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.4118% (minimum 60%, Enhanced); adrenal gland: 61.7647% (minimum 95%, Enhanced); amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 91.3043% (minimum 99%, Missing); bone marrow: 93.3333% (minimum 99%, Missing); cerebral cortex: 65.6250% (minimum 95%, Enhanced); choroid plexus: 77.7778% (minimum 99%, Missing); colon: 51.2195% (minimum 97%, Missing); duodenum: 12.8049% (minimum 99%, Missing); esophagus: 66.6667% (minimum 80%, Enhanced); heart muscle: 60.0000% (minimum 95%, Enhanced); hippocampal formation: 89.3617% (minimum 99%, Missing); hypothalamus: 91.3043% (minimum 99%, Missing); kidney: 52.5000% (minimum 95%, Enhanced); liver: 9.5023% (minimum 95%, Enhanced); lung: 61.7647% (minimum 95%, Enhanced); lymph node: 77.7778% (minimum 80%, Enhanced); midbrain: 91.3043% (minimum 99%, Missing); pancreas: 29.5775% (minimum 99%, Missing); pituitary gland: 75.0000% (minimum 99%, Missing); rectum: 49.4118% (minimum 97%, Missing); retina: 39.2523% (minimum 99%, Missing); salivary gland: 54.5455% (minimum 80%, Enhanced); skeletal muscle: 31.5789% (minimum 95%, Enhanced); skin: 59.1549% (minimum 60%, Enhanced); small intestine: 12.8834% (minimum 99%, Missing); smooth muscle: 58.3333% (minimum 95%, Enhanced); spinal cord: 93.3333% (minimum 99%, Missing); spleen: 40.7767% (minimum 60%, Enhanced); stomach: 31.8182% (minimum 80%, Enhanced); thymus: 91.3043% (minimum 95%, Missing); tongue: 56.7568% (minimum 97%, Missing); urinary bladder: 72.4138% (minimum 80%, Enhanced)",-0.192233,-0.481818,-0.861951,0,7,partial,40,9,6.1,"liver: 40 nTPM (vital, limit 6); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120341,SEC16B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.4118% (minimum 50%, Enhanced); colon: 51.2195% (minimum 70%, Missing); duodenum: 12.8049% (minimum 75%, Missing); kidney: 52.5000% (minimum 60%, Enhanced); liver: 9.5023% (minimum 60%, Enhanced); pancreas: 29.5775% (minimum 75%, Missing); rectum: 49.4118% (minimum 70%, Missing); retina: 39.2523% (minimum 75%, Missing); salivary gland: 54.5455% (minimum 55%, Enhanced); skeletal muscle: 31.5789% (minimum 60%, Enhanced); small intestine: 12.8834% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 60%, Enhanced); spleen: 40.7767% (minimum 50%, Enhanced); stomach: 31.8182% (minimum 55%, Enhanced); tongue: 56.7568% (minimum 70%, Missing)",-0.092233,-0.231818,-0.621951,0,7,partial,40,9,6.1,"liver: 40 nTPM (vital, limit 6); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120341,SEC16B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.4118% (minimum 50%, Enhanced); colon: 51.2195% (minimum 70%, Missing); duodenum: 12.8049% (minimum 75%, Missing); kidney: 52.5000% (minimum 60%, Enhanced); liver: 9.5023% (minimum 60%, Enhanced); pancreas: 29.5775% (minimum 75%, Missing); rectum: 49.4118% (minimum 70%, Missing); retina: 39.2523% (minimum 75%, Missing); salivary gland: 54.5455% (minimum 55%, Enhanced); skeletal muscle: 31.5789% (minimum 60%, Enhanced); small intestine: 12.8834% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 60%, Enhanced); spleen: 40.7767% (minimum 50%, Enhanced); stomach: 31.8182% (minimum 55%, Enhanced); tongue: 56.7568% (minimum 70%, Missing)",-0.092233,-0.231818,-0.621951,0,7,partial,40,9,6.1,"liver: 40 nTPM (vital, limit 6); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); colon: 4 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120341,SEC16B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.4118% (minimum 50%, Enhanced); colon: 51.2195% (minimum 70%, Missing); duodenum: 12.8049% (minimum 75%, Missing); kidney: 52.5000% (minimum 60%, Enhanced); liver: 9.5023% (minimum 60%, Enhanced); pancreas: 29.5775% (minimum 75%, Missing); rectum: 49.4118% (minimum 70%, Missing); retina: 39.2523% (minimum 75%, Missing); salivary gland: 54.5455% (minimum 55%, Enhanced); skeletal muscle: 31.5789% (minimum 60%, Enhanced); small intestine: 12.8834% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 60%, Enhanced); spleen: 40.7767% (minimum 50%, Enhanced); stomach: 31.8182% (minimum 55%, Enhanced); tongue: 56.7568% (minimum 70%, Missing)",-0.092233,-0.231818,-0.621951,0,7,partial,40,9,6.1,"liver: 40 nTPM (vital, limit 6); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); colon: 4 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120341,SEC16B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.4118% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 61.7647% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.6250% (minimum 75%, Baseline (adaptation disabled)); colon: 51.2195% (minimum 70%, Baseline (adaptation disabled)); duodenum: 12.8049% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 52.5000% (minimum 75%, Baseline (adaptation disabled)); liver: 9.5023% (minimum 75%, Baseline (adaptation disabled)); lung: 61.7647% (minimum 75%, Baseline (adaptation disabled)); pancreas: 29.5775% (minimum 75%, Baseline (adaptation disabled)); rectum: 49.4118% (minimum 70%, Baseline (adaptation disabled)); retina: 39.2523% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 54.5455% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 31.5789% (minimum 75%, Baseline (adaptation disabled)); skin: 59.1549% (minimum 65%, Baseline (adaptation disabled)); small intestine: 12.8834% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.3333% (minimum 75%, Baseline (adaptation disabled)); spleen: 40.7767% (minimum 65%, Baseline (adaptation disabled)); stomach: 31.8182% (minimum 70%, Baseline (adaptation disabled)); tongue: 56.7568% (minimum 70%, Baseline (adaptation disabled))",-0.242233,-0.381818,-0.654977,0,7,partial,40,9,6.1,"liver: 40 nTPM (vital, limit 1); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9 nTPM (protected, limit 3); retina: 6.5 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); rectum: 4.3 nTPM (protected, limit 3); colon: 4 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); smooth muscle: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120341,SEC16B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 87.5000% (minimum 99%, Missing); duodenum: 77.7778% (minimum 99%, Missing); lymph node: 33.3333% (minimum 97%, Missing); small intestine: 87.5000% (minimum 99%, Missing); spleen: 53.8462% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thymus: 70.0000% (minimum 95%, Missing)",-0.411538,-0.636667,-0.212222,0,80,unavailable,0.2,1.4,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120436,GPR31,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 33.3333% (minimum 70%, Missing); spleen: 53.8462% (minimum 65%, Missing)",-0.111538,-0.366667,0.0277778,0,80,unavailable,0.2,1.4,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120436,GPR31,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 33.3333% (minimum 70%, Missing); spleen: 53.8462% (minimum 65%, Missing)",-0.111538,-0.366667,0.0277778,0,80,unavailable,0.2,1.4,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120436,GPR31,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 33.3333% (minimum 70%, Missing); spleen: 53.8462% (minimum 65%, Missing)",-0.111538,-0.366667,0.0277778,0,80,unavailable,0.2,1.4,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120436,GPR31,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 33.3333% (minimum 70%, Baseline (adaptation disabled)); spleen: 53.8462% (minimum 65%, Baseline (adaptation disabled))",-0.111538,-0.366667,0.0277778,0,80,unavailable,0.2,1.4,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120436,GPR31,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 91.7949% (minimum 99%, Missing); small intestine: 98.3516% (minimum 99%, Missing); spinal cord: 98.8950% (minimum 99%, Missing)",0.0335165,0.00814208,-0.0720513,0,80,unavailable,1.6,0.4,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120440,TTLL2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333516,0.278142,0.167949,0,80,unavailable,1.6,0.4,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120440,TTLL2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333516,0.278142,0.167949,0,80,unavailable,1.6,0.4,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120440,TTLL2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333516,0.278142,0.167949,0,80,unavailable,1.6,0.4,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120440,TTLL2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333516,0.278142,0.167949,0,80,unavailable,1.6,0.4,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120440,TTLL2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.3407% (minimum 95%, Uncertain); adrenal gland: 53.6269% (minimum 99%, Missing); amygdala: 54.7619% (minimum 99%, Missing); basal ganglia: 52.4051% (minimum 99%, Missing); bone marrow: 70.6485% (minimum 99%, Uncertain); cerebellum: 60.5263% (minimum 99%, Missing); cerebral cortex: 56.4033% (minimum 99%, Missing); choroid plexus: 67.8689% (minimum 99%, Missing); colon: 49.0521% (minimum 97%, Missing); duodenum: 64.4860% (minimum 99%, Missing); esophagus: 59.1429% (minimum 97%, Uncertain); heart muscle: 51.4925% (minimum 99%, Missing); hippocampal formation: 54.4737% (minimum 99%, Missing); hypothalamus: 55.0532% (minimum 99%, Missing); kidney: 56.2500% (minimum 99%, Missing); liver: 52.4051% (minimum 99%, Missing); lung: 59.3123% (minimum 99%, Missing); lymph node: 65.9236% (minimum 97%, Uncertain); midbrain: 50.6112% (minimum 99%, Missing); pancreas: 52.2727% (minimum 99%, Missing); parathyroid gland: 57.1823% (minimum 97%, Missing); pituitary gland: 55.3476% (minimum 99%, Missing); rectum: 60.3499% (minimum 97%, Uncertain); retina: 57.9832% (minimum 99%, Missing); salivary gland: 52.2727% (minimum 97%, Uncertain); skeletal muscle: 47.3684% (minimum 99%, Missing); skin: 62.3494% (minimum 95%, Missing); small intestine: 57.9832% (minimum 99%, Missing); smooth muscle: 52.4051% (minimum 99%, Uncertain); spinal cord: 45.8980% (minimum 99%, Missing); spleen: 58.1461% (minimum 95%, Uncertain); stomach: 52.9412% (minimum 97%, Missing); thymus: 65.7143% (minimum 95%, Missing); thyroid gland: 49.7596% (minimum 95%, Missing); tongue: 61.9760% (minimum 97%, Missing); urinary bladder: 52.8061% (minimum 97%, Missing)",-0.452404,-0.479479,-0.53102,0,6,partial,24.4,21.5,20.9,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 2); thyroid gland: 20.9 nTPM (manageable, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); salivary gland: 18.9 nTPM (protected, limit 2); pancreas: 18.9 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 2); stomach: 18.4 nTPM (protected, limit 2); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 2); adipose tissue: 15.4 nTPM (manageable, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); esophagus: 14.3 nTPM (protected, limit 2); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 2); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); skin: 12.5 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 2); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120451,SNX19,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.3407% (minimum 65%, Uncertain); adrenal gland: 53.6269% (minimum 75%, Missing); amygdala: 54.7619% (minimum 75%, Missing); basal ganglia: 52.4051% (minimum 75%, Missing); bone marrow: 70.6485% (minimum 75%, Uncertain); cerebellum: 60.5263% (minimum 75%, Missing); cerebral cortex: 56.4033% (minimum 75%, Missing); choroid plexus: 67.8689% (minimum 75%, Missing); colon: 49.0521% (minimum 70%, Missing); duodenum: 64.4860% (minimum 75%, Missing); esophagus: 59.1429% (minimum 70%, Uncertain); heart muscle: 51.4925% (minimum 75%, Missing); hippocampal formation: 54.4737% (minimum 75%, Missing); hypothalamus: 55.0532% (minimum 75%, Missing); kidney: 56.2500% (minimum 75%, Missing); liver: 52.4051% (minimum 75%, Missing); lung: 59.3123% (minimum 75%, Missing); lymph node: 65.9236% (minimum 70%, Uncertain); midbrain: 50.6112% (minimum 75%, Missing); pancreas: 52.2727% (minimum 75%, Missing); parathyroid gland: 57.1823% (minimum 70%, Missing); pituitary gland: 55.3476% (minimum 75%, Missing); rectum: 60.3499% (minimum 70%, Uncertain); retina: 57.9832% (minimum 75%, Missing); salivary gland: 52.2727% (minimum 70%, Uncertain); skeletal muscle: 47.3684% (minimum 75%, Missing); skin: 62.3494% (minimum 65%, Missing); small intestine: 57.9832% (minimum 75%, Missing); smooth muscle: 52.4051% (minimum 75%, Uncertain); spinal cord: 45.8980% (minimum 75%, Missing); spleen: 58.1461% (minimum 65%, Uncertain); stomach: 52.9412% (minimum 70%, Missing); thyroid gland: 49.7596% (minimum 65%, Missing); tongue: 61.9760% (minimum 70%, Missing); urinary bladder: 52.8061% (minimum 70%, Missing)",-0.152404,-0.209479,-0.29102,0,6,partial,24.4,21.5,20.9,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 2); thyroid gland: 20.9 nTPM (manageable, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); salivary gland: 18.9 nTPM (protected, limit 2); pancreas: 18.9 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 2); stomach: 18.4 nTPM (protected, limit 2); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 2); adipose tissue: 15.4 nTPM (manageable, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); esophagus: 14.3 nTPM (protected, limit 2); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 2); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); skin: 12.5 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 2); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120451,SNX19,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.3407% (minimum 65%, Uncertain); adrenal gland: 53.6269% (minimum 75%, Missing); amygdala: 54.7619% (minimum 75%, Missing); basal ganglia: 52.4051% (minimum 75%, Missing); bone marrow: 70.6485% (minimum 75%, Uncertain); cerebellum: 60.5263% (minimum 75%, Missing); cerebral cortex: 56.4033% (minimum 75%, Missing); choroid plexus: 67.8689% (minimum 75%, Missing); colon: 49.0521% (minimum 70%, Missing); duodenum: 64.4860% (minimum 75%, Missing); esophagus: 59.1429% (minimum 70%, Uncertain); heart muscle: 51.4925% (minimum 75%, Missing); hippocampal formation: 54.4737% (minimum 75%, Missing); hypothalamus: 55.0532% (minimum 75%, Missing); kidney: 56.2500% (minimum 75%, Missing); liver: 52.4051% (minimum 75%, Missing); lung: 59.3123% (minimum 75%, Missing); lymph node: 65.9236% (minimum 70%, Uncertain); midbrain: 50.6112% (minimum 75%, Missing); pancreas: 52.2727% (minimum 75%, Missing); parathyroid gland: 57.1823% (minimum 70%, Missing); pituitary gland: 55.3476% (minimum 75%, Missing); rectum: 60.3499% (minimum 70%, Uncertain); retina: 57.9832% (minimum 75%, Missing); salivary gland: 52.2727% (minimum 70%, Uncertain); skeletal muscle: 47.3684% (minimum 75%, Missing); skin: 62.3494% (minimum 65%, Missing); small intestine: 57.9832% (minimum 75%, Missing); smooth muscle: 52.4051% (minimum 75%, Uncertain); spinal cord: 45.8980% (minimum 75%, Missing); spleen: 58.1461% (minimum 65%, Uncertain); stomach: 52.9412% (minimum 70%, Missing); thyroid gland: 49.7596% (minimum 65%, Missing); tongue: 61.9760% (minimum 70%, Missing); urinary bladder: 52.8061% (minimum 70%, Missing)",-0.152404,-0.209479,-0.29102,0,6,partial,24.4,21.5,20.9,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 3); thyroid gland: 20.9 nTPM (manageable, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); salivary gland: 18.9 nTPM (protected, limit 3); pancreas: 18.9 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 3); stomach: 18.4 nTPM (protected, limit 3); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 3); adipose tissue: 15.4 nTPM (manageable, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); esophagus: 14.3 nTPM (protected, limit 3); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 3); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); skin: 12.5 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 3); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120451,SNX19,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.3407% (minimum 65%, Uncertain); adrenal gland: 53.6269% (minimum 75%, Missing); amygdala: 54.7619% (minimum 75%, Missing); basal ganglia: 52.4051% (minimum 75%, Missing); bone marrow: 70.6485% (minimum 75%, Uncertain); cerebellum: 60.5263% (minimum 75%, Missing); cerebral cortex: 56.4033% (minimum 75%, Missing); choroid plexus: 67.8689% (minimum 75%, Missing); colon: 49.0521% (minimum 70%, Missing); duodenum: 64.4860% (minimum 75%, Missing); esophagus: 59.1429% (minimum 70%, Uncertain); heart muscle: 51.4925% (minimum 75%, Missing); hippocampal formation: 54.4737% (minimum 75%, Missing); hypothalamus: 55.0532% (minimum 75%, Missing); kidney: 56.2500% (minimum 75%, Missing); liver: 52.4051% (minimum 75%, Missing); lung: 59.3123% (minimum 75%, Missing); lymph node: 65.9236% (minimum 70%, Uncertain); midbrain: 50.6112% (minimum 75%, Missing); pancreas: 52.2727% (minimum 75%, Missing); parathyroid gland: 57.1823% (minimum 70%, Missing); pituitary gland: 55.3476% (minimum 75%, Missing); rectum: 60.3499% (minimum 70%, Uncertain); retina: 57.9832% (minimum 75%, Missing); salivary gland: 52.2727% (minimum 70%, Uncertain); skeletal muscle: 47.3684% (minimum 75%, Missing); skin: 62.3494% (minimum 65%, Missing); small intestine: 57.9832% (minimum 75%, Missing); smooth muscle: 52.4051% (minimum 75%, Uncertain); spinal cord: 45.8980% (minimum 75%, Missing); spleen: 58.1461% (minimum 65%, Uncertain); stomach: 52.9412% (minimum 70%, Missing); thyroid gland: 49.7596% (minimum 65%, Missing); tongue: 61.9760% (minimum 70%, Missing); urinary bladder: 52.8061% (minimum 70%, Missing)",-0.152404,-0.209479,-0.29102,0,6,partial,24.4,21.5,20.9,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 3); thyroid gland: 20.9 nTPM (manageable, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); salivary gland: 18.9 nTPM (protected, limit 3); pancreas: 18.9 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 3); stomach: 18.4 nTPM (protected, limit 3); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 3); adipose tissue: 15.4 nTPM (manageable, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); esophagus: 14.3 nTPM (protected, limit 3); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 3); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); skin: 12.5 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 3); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120451,SNX19,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.3407% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 53.6269% (minimum 75%, Baseline (adaptation disabled)); amygdala: 54.7619% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 52.4051% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 70.6485% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.5263% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.4033% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.8689% (minimum 75%, Baseline (adaptation disabled)); colon: 49.0521% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.4860% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.1429% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 51.4925% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.4737% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.0532% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.2500% (minimum 75%, Baseline (adaptation disabled)); liver: 52.4051% (minimum 75%, Baseline (adaptation disabled)); lung: 59.3123% (minimum 75%, Baseline (adaptation disabled)); lymph node: 65.9236% (minimum 70%, Baseline (adaptation disabled)); midbrain: 50.6112% (minimum 75%, Baseline (adaptation disabled)); pancreas: 52.2727% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.1823% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.3476% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.3499% (minimum 70%, Baseline (adaptation disabled)); retina: 57.9832% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 52.2727% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 47.3684% (minimum 75%, Baseline (adaptation disabled)); skin: 62.3494% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.9832% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 52.4051% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 45.8980% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.1461% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.9412% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 49.7596% (minimum 65%, Baseline (adaptation disabled)); tongue: 61.9760% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.8061% (minimum 70%, Baseline (adaptation disabled))",-0.152404,-0.209479,-0.29102,0,6,partial,24.4,21.5,20.9,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 3); thyroid gland: 20.9 nTPM (manageable, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); salivary gland: 18.9 nTPM (protected, limit 3); pancreas: 18.9 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 3); stomach: 18.4 nTPM (protected, limit 3); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 3); adipose tissue: 15.4 nTPM (manageable, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); esophagus: 14.3 nTPM (protected, limit 3); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 3); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); skin: 12.5 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 3); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120451,SNX19,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.3815% (minimum 99%, Missing); colon: 88.9764% (minimum 95%, Approved); pancreas: 16.5447% (minimum 98%, Approved); rectum: 88.2812% (minimum 95%, Approved)",0.0262295,-0.0671875,-0.814553,0,1,partial,57,1.5,0.9,"pancreas: 57 nTPM (vital, limit 2); choroid plexus: 13.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120498,TEX11,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.3815% (minimum 75%, Missing); pancreas: 16.5447% (minimum 70%, Approved)",0.32623,0.232812,-0.534553,0,1,partial,57,1.5,0.9,"pancreas: 57 nTPM (vital, limit 2); choroid plexus: 13.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120498,TEX11,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.3815% (minimum 75%, Missing); pancreas: 16.5447% (minimum 70%, Approved)",0.32623,0.232812,-0.534553,0,1,partial,57,1.5,0.9,"pancreas: 57 nTPM (vital, limit 2); choroid plexus: 13.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120498,TEX11,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.3815% (minimum 75%, Missing); pancreas: 16.5447% (minimum 70%, Approved)",0.32623,0.232812,-0.534553,0,1,partial,57,1.5,0.9,"pancreas: 57 nTPM (vital, limit 2); choroid plexus: 13.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120498,TEX11,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.3815% (minimum 75%, Baseline (adaptation disabled)); pancreas: 16.5447% (minimum 75%, Baseline (adaptation disabled))",0.27623,0.182813,-0.584553,0,1,partial,57,1.5,0.9,"pancreas: 57 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120498,TEX11,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.1860% (minimum 95%, Missing); adrenal gland: 73.0061% (minimum 99%, Missing); amygdala: 86.8613% (minimum 99%, Missing); basal ganglia: 86.8613% (minimum 99%, Missing); bone marrow: 66.8539% (minimum 99%, Missing); cerebellum: 86.8613% (minimum 99%, Missing); cerebral cortex: 82.6389% (minimum 99%, Missing); choroid plexus: 88.1481% (minimum 99%, Missing); colon: 63.9785% (minimum 97%, Missing); duodenum: 72.5610% (minimum 99%, Missing); esophagus: 68.0000% (minimum 97%, Missing); heart muscle: 80.9524% (minimum 99%, Missing); hippocampal formation: 86.2319% (minimum 99%, Missing); hypothalamus: 86.2319% (minimum 99%, Missing); kidney: 76.7742% (minimum 99%, Missing); liver: 62.9630% (minimum 99%, Missing); lung: 67.6136% (minimum 99%, Missing); lymph node: 68.7861% (minimum 97%, Missing); midbrain: 83.8028% (minimum 99%, Missing); pancreas: 65.3846% (minimum 99%, Missing); parathyroid gland: 76.7742% (minimum 97%, Missing); pituitary gland: 77.2727% (minimum 99%, Missing); rectum: 57.2115% (minimum 97%, Missing); retina: 75.7962% (minimum 99%, Missing); salivary gland: 64.3243% (minimum 97%, Missing); skeletal muscle: 84.3972% (minimum 99%, Missing); skin: 76.7742% (minimum 95%, Missing); small intestine: 69.1860% (minimum 99%, Missing); smooth muscle: 68.0000% (minimum 99%, Missing); spinal cord: 80.9524% (minimum 99%, Missing); spleen: 69.5906% (minimum 95%, Missing); stomach: 55.3488% (minimum 97%, Missing); thymus: 65.3846% (minimum 95%, Missing); thyroid gland: 63.9785% (minimum 95%, Missing); tongue: 79.3333% (minimum 97%, Missing); urinary bladder: 72.5610% (minimum 97%, Missing)",-0.310215,-0.416512,-0.36037,0,80,unavailable,7,9.6,6.7,"stomach: 9.6 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); colon: 6.7 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 2); lymph node: 5.4 nTPM (protected, limit 2); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); urinary bladder: 4.5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); pituitary gland: 3.5 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120519,SLC10A7,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.0061% (minimum 75%, Missing); bone marrow: 66.8539% (minimum 75%, Missing); colon: 63.9785% (minimum 70%, Missing); duodenum: 72.5610% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); liver: 62.9630% (minimum 75%, Missing); lung: 67.6136% (minimum 75%, Missing); lymph node: 68.7861% (minimum 70%, Missing); pancreas: 65.3846% (minimum 75%, Missing); rectum: 57.2115% (minimum 70%, Missing); salivary gland: 64.3243% (minimum 70%, Missing); small intestine: 69.1860% (minimum 75%, Missing); smooth muscle: 68.0000% (minimum 75%, Missing); stomach: 55.3488% (minimum 70%, Missing); thyroid gland: 63.9785% (minimum 65%, Missing)",-0.0102151,-0.146512,-0.12037,0,80,unavailable,7,9.6,6.7,"stomach: 9.6 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); colon: 6.7 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 2); lymph node: 5.4 nTPM (protected, limit 2); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); urinary bladder: 4.5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); pituitary gland: 3.5 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120519,SLC10A7,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.0061% (minimum 75%, Missing); bone marrow: 66.8539% (minimum 75%, Missing); colon: 63.9785% (minimum 70%, Missing); duodenum: 72.5610% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); liver: 62.9630% (minimum 75%, Missing); lung: 67.6136% (minimum 75%, Missing); lymph node: 68.7861% (minimum 70%, Missing); pancreas: 65.3846% (minimum 75%, Missing); rectum: 57.2115% (minimum 70%, Missing); salivary gland: 64.3243% (minimum 70%, Missing); small intestine: 69.1860% (minimum 75%, Missing); smooth muscle: 68.0000% (minimum 75%, Missing); stomach: 55.3488% (minimum 70%, Missing); thyroid gland: 63.9785% (minimum 65%, Missing)",-0.0102151,-0.146512,-0.12037,0,80,unavailable,7,9.6,6.7,"stomach: 9.6 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); colon: 6.7 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 3); lymph node: 5.4 nTPM (protected, limit 3); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); urinary bladder: 4.5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120519,SLC10A7,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.0061% (minimum 75%, Missing); bone marrow: 66.8539% (minimum 75%, Missing); colon: 63.9785% (minimum 70%, Missing); duodenum: 72.5610% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); liver: 62.9630% (minimum 75%, Missing); lung: 67.6136% (minimum 75%, Missing); lymph node: 68.7861% (minimum 70%, Missing); pancreas: 65.3846% (minimum 75%, Missing); rectum: 57.2115% (minimum 70%, Missing); salivary gland: 64.3243% (minimum 70%, Missing); small intestine: 69.1860% (minimum 75%, Missing); smooth muscle: 68.0000% (minimum 75%, Missing); stomach: 55.3488% (minimum 70%, Missing); thyroid gland: 63.9785% (minimum 65%, Missing)",-0.0102151,-0.146512,-0.12037,0,80,unavailable,7,9.6,6.7,"stomach: 9.6 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); colon: 6.7 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 3); lymph node: 5.4 nTPM (protected, limit 3); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); urinary bladder: 4.5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120519,SLC10A7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.0061% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.8539% (minimum 75%, Baseline (adaptation disabled)); colon: 63.9785% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.5610% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.0000% (minimum 70%, Baseline (adaptation disabled)); liver: 62.9630% (minimum 75%, Baseline (adaptation disabled)); lung: 67.6136% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.7861% (minimum 70%, Baseline (adaptation disabled)); pancreas: 65.3846% (minimum 75%, Baseline (adaptation disabled)); rectum: 57.2115% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 64.3243% (minimum 70%, Baseline (adaptation disabled)); small intestine: 69.1860% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.0000% (minimum 75%, Baseline (adaptation disabled)); stomach: 55.3488% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 63.9785% (minimum 65%, Baseline (adaptation disabled))",-0.0102151,-0.146512,-0.12037,0,80,unavailable,7,9.6,6.7,"stomach: 9.6 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); colon: 6.7 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 3); lymph node: 5.4 nTPM (protected, limit 3); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); urinary bladder: 4.5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120519,SLC10A7,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.00798793,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120563,LYZL1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247988,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120563,LYZL1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247988,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120563,LYZL1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247988,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120563,LYZL1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247988,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120563,LYZL1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.7101% (minimum 95%, Missing); adrenal gland: 68.8963% (minimum 99%, Missing); amygdala: 72.2807% (minimum 99%, Missing); basal ganglia: 70.7904% (minimum 99%, Missing); bone marrow: 12.2400% (minimum 99%, Missing); cerebellum: 49.0476% (minimum 99%, Missing); cerebral cortex: 68.2119% (minimum 99%, Missing); choroid plexus: 67.5410% (minimum 99%, Missing); colon: 57.2222% (minimum 97%, Missing); duodenum: 64.9842% (minimum 99%, Missing); esophagus: 65.6051% (minimum 97%, Missing); heart muscle: 64.1745% (minimum 99%, Missing); hippocampal formation: 71.2803% (minimum 99%, Missing); hypothalamus: 72.7915% (minimum 99%, Missing); kidney: 64.1745% (minimum 99%, Missing); liver: 60.5882% (minimum 99%, Missing); lung: 59.0258% (minimum 99%, Missing); lymph node: 49.5192% (minimum 97%, Missing); midbrain: 73.5714% (minimum 99%, Missing); pancreas: 59.7101% (minimum 99%, Missing); parathyroid gland: 59.3660% (minimum 97%, Missing); pituitary gland: 67.1010% (minimum 99%, Missing); rectum: 56.9061% (minimum 97%, Missing); retina: 52.4173% (minimum 99%, Missing); salivary gland: 58.5227% (minimum 97%, Missing); skeletal muscle: 48.4706% (minimum 99%, Missing); skin: 60.5882% (minimum 95%, Missing); small intestine: 62.0482% (minimum 99%, Missing); smooth muscle: 55.9783% (minimum 99%, Missing); spinal cord: 70.7904% (minimum 99%, Missing); spleen: 53.2300% (minimum 95%, Missing); stomach: 60.2339% (minimum 97%, Missing); thymus: 39.9225% (minimum 95%, Missing); thyroid gland: 55.8266% (minimum 95%, Missing); tongue: 47.7958% (minimum 97%, Missing); urinary bladder: 58.3569% (minimum 97%, Missing)",-0.550775,-0.492042,-0.8676,0,80,unavailable,147.7,22.5,31,"bone marrow: 147.7 nTPM (vital, limit 1); thymus: 31 nTPM (manageable, limit 5); tongue: 22.5 nTPM (protected, limit 2); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 2); retina: 18.7 nTPM (vital, limit 1); spleen: 18.1 nTPM (manageable, limit 5); thyroid gland: 16.3 nTPM (manageable, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 2); colon: 15.4 nTPM (protected, limit 2); urinary bladder: 14.7 nTPM (protected, limit 2); salivary gland: 14.6 nTPM (protected, limit 2); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); pancreas: 13.9 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); stomach: 13.6 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 2); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120616,EPC1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.7101% (minimum 65%, Missing); adrenal gland: 68.8963% (minimum 75%, Missing); amygdala: 72.2807% (minimum 75%, Missing); basal ganglia: 70.7904% (minimum 75%, Missing); bone marrow: 12.2400% (minimum 75%, Missing); cerebellum: 49.0476% (minimum 75%, Missing); cerebral cortex: 68.2119% (minimum 75%, Missing); choroid plexus: 67.5410% (minimum 75%, Missing); colon: 57.2222% (minimum 70%, Missing); duodenum: 64.9842% (minimum 75%, Missing); esophagus: 65.6051% (minimum 70%, Missing); heart muscle: 64.1745% (minimum 75%, Missing); hippocampal formation: 71.2803% (minimum 75%, Missing); hypothalamus: 72.7915% (minimum 75%, Missing); kidney: 64.1745% (minimum 75%, Missing); liver: 60.5882% (minimum 75%, Missing); lung: 59.0258% (minimum 75%, Missing); lymph node: 49.5192% (minimum 70%, Missing); midbrain: 73.5714% (minimum 75%, Missing); pancreas: 59.7101% (minimum 75%, Missing); parathyroid gland: 59.3660% (minimum 70%, Missing); pituitary gland: 67.1010% (minimum 75%, Missing); rectum: 56.9061% (minimum 70%, Missing); retina: 52.4173% (minimum 75%, Missing); salivary gland: 58.5227% (minimum 70%, Missing); skeletal muscle: 48.4706% (minimum 75%, Missing); skin: 60.5882% (minimum 65%, Missing); small intestine: 62.0482% (minimum 75%, Missing); smooth muscle: 55.9783% (minimum 75%, Missing); spinal cord: 70.7904% (minimum 75%, Missing); spleen: 53.2300% (minimum 65%, Missing); stomach: 60.2339% (minimum 70%, Missing); thymus: 39.9225% (minimum 65%, Missing); thyroid gland: 55.8266% (minimum 65%, Missing); tongue: 47.7958% (minimum 70%, Missing); urinary bladder: 58.3569% (minimum 70%, Missing)",-0.250775,-0.222042,-0.6276,0,80,unavailable,147.7,22.5,31,"bone marrow: 147.7 nTPM (vital, limit 1); thymus: 31 nTPM (manageable, limit 5); tongue: 22.5 nTPM (protected, limit 2); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 2); retina: 18.7 nTPM (vital, limit 1); spleen: 18.1 nTPM (manageable, limit 5); thyroid gland: 16.3 nTPM (manageable, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 2); colon: 15.4 nTPM (protected, limit 2); urinary bladder: 14.7 nTPM (protected, limit 2); salivary gland: 14.6 nTPM (protected, limit 2); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); pancreas: 13.9 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); stomach: 13.6 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 2); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120616,EPC1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.7101% (minimum 65%, Missing); adrenal gland: 68.8963% (minimum 75%, Missing); amygdala: 72.2807% (minimum 75%, Missing); basal ganglia: 70.7904% (minimum 75%, Missing); bone marrow: 12.2400% (minimum 75%, Missing); cerebellum: 49.0476% (minimum 75%, Missing); cerebral cortex: 68.2119% (minimum 75%, Missing); choroid plexus: 67.5410% (minimum 75%, Missing); colon: 57.2222% (minimum 70%, Missing); duodenum: 64.9842% (minimum 75%, Missing); esophagus: 65.6051% (minimum 70%, Missing); heart muscle: 64.1745% (minimum 75%, Missing); hippocampal formation: 71.2803% (minimum 75%, Missing); hypothalamus: 72.7915% (minimum 75%, Missing); kidney: 64.1745% (minimum 75%, Missing); liver: 60.5882% (minimum 75%, Missing); lung: 59.0258% (minimum 75%, Missing); lymph node: 49.5192% (minimum 70%, Missing); midbrain: 73.5714% (minimum 75%, Missing); pancreas: 59.7101% (minimum 75%, Missing); parathyroid gland: 59.3660% (minimum 70%, Missing); pituitary gland: 67.1010% (minimum 75%, Missing); rectum: 56.9061% (minimum 70%, Missing); retina: 52.4173% (minimum 75%, Missing); salivary gland: 58.5227% (minimum 70%, Missing); skeletal muscle: 48.4706% (minimum 75%, Missing); skin: 60.5882% (minimum 65%, Missing); small intestine: 62.0482% (minimum 75%, Missing); smooth muscle: 55.9783% (minimum 75%, Missing); spinal cord: 70.7904% (minimum 75%, Missing); spleen: 53.2300% (minimum 65%, Missing); stomach: 60.2339% (minimum 70%, Missing); thymus: 39.9225% (minimum 65%, Missing); thyroid gland: 55.8266% (minimum 65%, Missing); tongue: 47.7958% (minimum 70%, Missing); urinary bladder: 58.3569% (minimum 70%, Missing)",-0.250775,-0.222042,-0.6276,0,80,unavailable,147.7,22.5,31,"bone marrow: 147.7 nTPM (vital, limit 1); thymus: 31 nTPM (manageable, limit 5); tongue: 22.5 nTPM (protected, limit 3); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 3); retina: 18.7 nTPM (vital, limit 1); spleen: 18.1 nTPM (manageable, limit 5); thyroid gland: 16.3 nTPM (manageable, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 3); colon: 15.4 nTPM (protected, limit 3); urinary bladder: 14.7 nTPM (protected, limit 3); salivary gland: 14.6 nTPM (protected, limit 3); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); pancreas: 13.9 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); stomach: 13.6 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 3); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120616,EPC1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.7101% (minimum 65%, Missing); adrenal gland: 68.8963% (minimum 75%, Missing); amygdala: 72.2807% (minimum 75%, Missing); basal ganglia: 70.7904% (minimum 75%, Missing); bone marrow: 12.2400% (minimum 75%, Missing); cerebellum: 49.0476% (minimum 75%, Missing); cerebral cortex: 68.2119% (minimum 75%, Missing); choroid plexus: 67.5410% (minimum 75%, Missing); colon: 57.2222% (minimum 70%, Missing); duodenum: 64.9842% (minimum 75%, Missing); esophagus: 65.6051% (minimum 70%, Missing); heart muscle: 64.1745% (minimum 75%, Missing); hippocampal formation: 71.2803% (minimum 75%, Missing); hypothalamus: 72.7915% (minimum 75%, Missing); kidney: 64.1745% (minimum 75%, Missing); liver: 60.5882% (minimum 75%, Missing); lung: 59.0258% (minimum 75%, Missing); lymph node: 49.5192% (minimum 70%, Missing); midbrain: 73.5714% (minimum 75%, Missing); pancreas: 59.7101% (minimum 75%, Missing); parathyroid gland: 59.3660% (minimum 70%, Missing); pituitary gland: 67.1010% (minimum 75%, Missing); rectum: 56.9061% (minimum 70%, Missing); retina: 52.4173% (minimum 75%, Missing); salivary gland: 58.5227% (minimum 70%, Missing); skeletal muscle: 48.4706% (minimum 75%, Missing); skin: 60.5882% (minimum 65%, Missing); small intestine: 62.0482% (minimum 75%, Missing); smooth muscle: 55.9783% (minimum 75%, Missing); spinal cord: 70.7904% (minimum 75%, Missing); spleen: 53.2300% (minimum 65%, Missing); stomach: 60.2339% (minimum 70%, Missing); thymus: 39.9225% (minimum 65%, Missing); thyroid gland: 55.8266% (minimum 65%, Missing); tongue: 47.7958% (minimum 70%, Missing); urinary bladder: 58.3569% (minimum 70%, Missing)",-0.250775,-0.222042,-0.6276,0,80,unavailable,147.7,22.5,31,"bone marrow: 147.7 nTPM (vital, limit 1); thymus: 31 nTPM (manageable, limit 5); tongue: 22.5 nTPM (protected, limit 3); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 3); retina: 18.7 nTPM (vital, limit 1); spleen: 18.1 nTPM (manageable, limit 5); thyroid gland: 16.3 nTPM (manageable, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 3); colon: 15.4 nTPM (protected, limit 3); urinary bladder: 14.7 nTPM (protected, limit 3); salivary gland: 14.6 nTPM (protected, limit 3); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); pancreas: 13.9 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); stomach: 13.6 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 3); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120616,EPC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.7101% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 68.8963% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.2807% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.7904% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 12.2400% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 49.0476% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.2119% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.5410% (minimum 75%, Baseline (adaptation disabled)); colon: 57.2222% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.9842% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.6051% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.1745% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.2803% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.7915% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.1745% (minimum 75%, Baseline (adaptation disabled)); liver: 60.5882% (minimum 75%, Baseline (adaptation disabled)); lung: 59.0258% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.5192% (minimum 70%, Baseline (adaptation disabled)); midbrain: 73.5714% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.7101% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.3660% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.1010% (minimum 75%, Baseline (adaptation disabled)); rectum: 56.9061% (minimum 70%, Baseline (adaptation disabled)); retina: 52.4173% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.5227% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 48.4706% (minimum 75%, Baseline (adaptation disabled)); skin: 60.5882% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.0482% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.9783% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.7904% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.2300% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.2339% (minimum 70%, Baseline (adaptation disabled)); thymus: 39.9225% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.8266% (minimum 65%, Baseline (adaptation disabled)); tongue: 47.7958% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.3569% (minimum 70%, Baseline (adaptation disabled))",-0.250775,-0.222042,-0.6276,0,80,unavailable,147.7,22.5,31,"bone marrow: 147.7 nTPM (vital, limit 1); thymus: 31 nTPM (manageable, limit 5); tongue: 22.5 nTPM (protected, limit 3); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 3); retina: 18.7 nTPM (vital, limit 1); spleen: 18.1 nTPM (manageable, limit 5); thyroid gland: 16.3 nTPM (manageable, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 3); colon: 15.4 nTPM (protected, limit 3); urinary bladder: 14.7 nTPM (protected, limit 3); salivary gland: 14.6 nTPM (protected, limit 3); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); pancreas: 13.9 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); stomach: 13.6 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 3); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120616,EPC1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 93.1034% (minimum 99%, Missing); duodenum: 90.0000% (minimum 95%, Enhanced); liver: 40.2985% (minimum 95%, Enhanced); lymph node: 18.3673% (minimum 97%, Missing); rectum: 61.3636% (minimum 80%, Enhanced); small intestine: 62.7907% (minimum 95%, Enhanced); spleen: 87.0968% (minimum 95%, Missing); thymus: 69.2308% (minimum 95%, Missing); urinary bladder: 77.1429% (minimum 80%, Enhanced)",-0.257692,-0.786327,-0.547015,0,1,partial,4,12,1.2,"lymph node: 12 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120659,TNFSF11,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"liver: 40.2985% (minimum 60%, Enhanced); lymph node: 18.3673% (minimum 70%, Missing)",0.0423077,-0.516327,-0.197015,0,1,partial,4,12,1.2,"lymph node: 12 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120659,TNFSF11,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"liver: 40.2985% (minimum 60%, Enhanced); lymph node: 18.3673% (minimum 70%, Missing)",0.0423077,-0.516327,-0.197015,0,1,partial,4,12,1.2,"lymph node: 12 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120659,TNFSF11,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"liver: 40.2985% (minimum 60%, Enhanced); lymph node: 18.3673% (minimum 70%, Missing)",0.0423077,-0.516327,-0.197015,0,1,partial,4,12,1.2,"lymph node: 12 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120659,TNFSF11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"liver: 40.2985% (minimum 75%, Baseline (adaptation disabled)); lymph node: 18.3673% (minimum 70%, Baseline (adaptation disabled)); rectum: 61.3636% (minimum 70%, Baseline (adaptation disabled)); small intestine: 62.7907% (minimum 75%, Baseline (adaptation disabled))",0.0423077,-0.516327,-0.347015,0,1,partial,4,12,1.2,"lymph node: 12 nTPM (protected, limit 3); liver: 4 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120659,TNFSF11,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5240% (minimum 99%, Missing); amygdala: 97.0909% (minimum 99%, Missing); basal ganglia: 93.6842% (minimum 99%, Missing); bone marrow: 97.0909% (minimum 99%, Missing); cerebral cortex: 96.0432% (minimum 99%, Missing); choroid plexus: 96.7391% (minimum 99%, Missing); colon: 93.3566% (minimum 97%, Missing); duodenum: 98.8889% (minimum 99%, Missing); heart muscle: 96.3899% (minimum 99%, Missing); hippocampal formation: 95.6989% (minimum 99%, Missing); hypothalamus: 95.3571% (minimum 99%, Missing); kidney: 97.4453% (minimum 99%, Missing); midbrain: 96.7391% (minimum 99%, Missing); parathyroid gland: 95.0178% (minimum 97%, Missing); retina: 96.0432% (minimum 99%, Missing); skeletal muscle: 97.8022% (minimum 99%, Missing); smooth muscle: 98.1618% (minimum 99%, Missing); spinal cord: 97.4453% (minimum 99%, Missing); tongue: 83.9623% (minimum 97%, Missing); urinary bladder: 96.7391% (minimum 97%, Missing)",0.0316176,-0.130377,-0.0531579,0,80,unavailable,1.8,5.1,0.5,"tongue: 5.1 nTPM (protected, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120669,SOHLH2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331618,0.139623,0.186842,0,80,unavailable,1.8,5.1,0.5,"tongue: 5.1 nTPM (protected, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120669,SOHLH2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331618,0.139623,0.186842,0,80,unavailable,1.8,5.1,0.5,"tongue: 5.1 nTPM (protected, limit 3); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120669,SOHLH2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331618,0.139623,0.186842,0,80,unavailable,1.8,5.1,0.5,"tongue: 5.1 nTPM (protected, limit 3); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120669,SOHLH2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331618,0.139623,0.186842,0,80,unavailable,1.8,5.1,0.5,"tongue: 5.1 nTPM (protected, limit 3); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120669,SOHLH2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120952,PRAMEF2,admission_only,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120952,PRAMEF2,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120952,PRAMEF2,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120952,PRAMEF2,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000120952,PRAMEF2,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.5729% (minimum 95%, Missing); adrenal gland: 85.3659% (minimum 99%, Missing); amygdala: 86.6337% (minimum 99%, Missing); basal ganglia: 86.8486% (minimum 99%, Missing); bone marrow: 91.6230% (minimum 99%, Missing); cerebellum: 96.1538% (minimum 99%, Missing); cerebral cortex: 83.7321% (minimum 99%, Missing); choroid plexus: 69.3069% (minimum 99%, Missing); colon: 68.6275% (minimum 97%, Missing); duodenum: 52.6316% (minimum 99%, Missing); esophagus: 64.5756% (minimum 97%, Missing); heart muscle: 75.7576% (minimum 99%, Missing); hippocampal formation: 90.6736% (minimum 99%, Missing); hypothalamus: 89.0585% (minimum 99%, Missing); kidney: 45.3956% (minimum 99%, Missing); liver: 46.8541% (minimum 99%, Missing); lung: 72.6141% (minimum 99%, Missing); lymph node: 76.5864% (minimum 97%, Missing); midbrain: 90.2062% (minimum 99%, Missing); pancreas: 51.1696% (minimum 99%, Missing); parathyroid gland: 81.2065% (minimum 97%, Missing); pituitary gland: 57.3770% (minimum 99%, Missing); rectum: 70.4225% (minimum 97%, Missing); retina: 29.5110% (minimum 99%, Missing); salivary gland: 47.8796% (minimum 97%, Missing); skeletal muscle: 83.9329% (minimum 99%, Missing); skin: 81.2065% (minimum 95%, Missing); small intestine: 54.0123% (minimum 99%, Missing); smooth muscle: 70.9939% (minimum 99%, Missing); spinal cord: 88.1612% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 59.3220% (minimum 97%, Missing); thymus: 85.5746% (minimum 95%, Missing); thyroid gland: 84.7458% (minimum 95%, Missing); tongue: 81.5851% (minimum 97%, Missing); urinary bladder: 34.4488% (minimum 97%, Missing)",-0.494271,-0.625512,-0.69489,0,80,unavailable,83.6,66.6,41.8,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 2); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (manageable, limit 5); liver: 39.7 nTPM (vital, limit 1); salivary gland: 38.1 nTPM (protected, limit 2); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 2); esophagus: 19.2 nTPM (protected, limit 2); colon: 16 nTPM (protected, limit 2); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 2); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 2); skin: 8.1 nTPM (manageable, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 2); tongue: 7.9 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121039,RDH10,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.5729% (minimum 65%, Missing); choroid plexus: 69.3069% (minimum 75%, Missing); colon: 68.6275% (minimum 70%, Missing); duodenum: 52.6316% (minimum 75%, Missing); esophagus: 64.5756% (minimum 70%, Missing); kidney: 45.3956% (minimum 75%, Missing); liver: 46.8541% (minimum 75%, Missing); lung: 72.6141% (minimum 75%, Missing); pancreas: 51.1696% (minimum 75%, Missing); pituitary gland: 57.3770% (minimum 75%, Missing); retina: 29.5110% (minimum 75%, Missing); salivary gland: 47.8796% (minimum 70%, Missing); small intestine: 54.0123% (minimum 75%, Missing); smooth muscle: 70.9939% (minimum 75%, Missing); stomach: 59.3220% (minimum 70%, Missing); urinary bladder: 34.4488% (minimum 70%, Missing)",-0.194271,-0.355512,-0.45489,0,80,unavailable,83.6,66.6,41.8,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 2); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (manageable, limit 5); liver: 39.7 nTPM (vital, limit 1); salivary gland: 38.1 nTPM (protected, limit 2); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 2); esophagus: 19.2 nTPM (protected, limit 2); colon: 16 nTPM (protected, limit 2); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 2); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 2); skin: 8.1 nTPM (manageable, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 2); tongue: 7.9 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121039,RDH10,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.5729% (minimum 65%, Missing); choroid plexus: 69.3069% (minimum 75%, Missing); colon: 68.6275% (minimum 70%, Missing); duodenum: 52.6316% (minimum 75%, Missing); esophagus: 64.5756% (minimum 70%, Missing); kidney: 45.3956% (minimum 75%, Missing); liver: 46.8541% (minimum 75%, Missing); lung: 72.6141% (minimum 75%, Missing); pancreas: 51.1696% (minimum 75%, Missing); pituitary gland: 57.3770% (minimum 75%, Missing); retina: 29.5110% (minimum 75%, Missing); salivary gland: 47.8796% (minimum 70%, Missing); small intestine: 54.0123% (minimum 75%, Missing); smooth muscle: 70.9939% (minimum 75%, Missing); stomach: 59.3220% (minimum 70%, Missing); urinary bladder: 34.4488% (minimum 70%, Missing)",-0.194271,-0.355512,-0.45489,0,80,unavailable,83.6,66.6,41.8,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 3); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (manageable, limit 5); liver: 39.7 nTPM (vital, limit 1); salivary gland: 38.1 nTPM (protected, limit 3); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 3); esophagus: 19.2 nTPM (protected, limit 3); colon: 16 nTPM (protected, limit 3); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 3); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 3); skin: 8.1 nTPM (manageable, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 3); tongue: 7.9 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121039,RDH10,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.5729% (minimum 65%, Missing); choroid plexus: 69.3069% (minimum 75%, Missing); colon: 68.6275% (minimum 70%, Missing); duodenum: 52.6316% (minimum 75%, Missing); esophagus: 64.5756% (minimum 70%, Missing); kidney: 45.3956% (minimum 75%, Missing); liver: 46.8541% (minimum 75%, Missing); lung: 72.6141% (minimum 75%, Missing); pancreas: 51.1696% (minimum 75%, Missing); pituitary gland: 57.3770% (minimum 75%, Missing); retina: 29.5110% (minimum 75%, Missing); salivary gland: 47.8796% (minimum 70%, Missing); small intestine: 54.0123% (minimum 75%, Missing); smooth muscle: 70.9939% (minimum 75%, Missing); stomach: 59.3220% (minimum 70%, Missing); urinary bladder: 34.4488% (minimum 70%, Missing)",-0.194271,-0.355512,-0.45489,0,80,unavailable,83.6,66.6,41.8,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 3); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (manageable, limit 5); liver: 39.7 nTPM (vital, limit 1); salivary gland: 38.1 nTPM (protected, limit 3); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 3); esophagus: 19.2 nTPM (protected, limit 3); colon: 16 nTPM (protected, limit 3); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 3); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 3); skin: 8.1 nTPM (manageable, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 3); tongue: 7.9 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121039,RDH10,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.5729% (minimum 65%, Baseline (adaptation disabled)); choroid plexus: 69.3069% (minimum 75%, Baseline (adaptation disabled)); colon: 68.6275% (minimum 70%, Baseline (adaptation disabled)); duodenum: 52.6316% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.5756% (minimum 70%, Baseline (adaptation disabled)); kidney: 45.3956% (minimum 75%, Baseline (adaptation disabled)); liver: 46.8541% (minimum 75%, Baseline (adaptation disabled)); lung: 72.6141% (minimum 75%, Baseline (adaptation disabled)); pancreas: 51.1696% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 57.3770% (minimum 75%, Baseline (adaptation disabled)); retina: 29.5110% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 47.8796% (minimum 70%, Baseline (adaptation disabled)); small intestine: 54.0123% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.9939% (minimum 75%, Baseline (adaptation disabled)); stomach: 59.3220% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 34.4488% (minimum 70%, Baseline (adaptation disabled))",-0.194271,-0.355512,-0.45489,0,80,unavailable,83.6,66.6,41.8,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 3); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (manageable, limit 5); liver: 39.7 nTPM (vital, limit 1); salivary gland: 38.1 nTPM (protected, limit 3); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 3); esophagus: 19.2 nTPM (protected, limit 3); colon: 16 nTPM (protected, limit 3); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 3); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 3); skin: 8.1 nTPM (manageable, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 3); tongue: 7.9 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121039,RDH10,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.8679% (minimum 99%, Missing); basal ganglia: 98.8679% (minimum 99%, Missing); bone marrow: 93.9068% (minimum 95%, Enhanced); hippocampal formation: 98.8679% (minimum 99%, Missing); hypothalamus: 98.8679% (minimum 99%, Missing); midbrain: 98.8679% (minimum 99%, Missing); retina: 96.3235% (minimum 99%, Missing); spinal cord: 98.8679% (minimum 99%, Missing)",0.05,0.03,-0.0267647,0,3,partial,1.7,0.1,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121101,TEX14,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.213235,0,3,partial,1.7,0.1,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121101,TEX14,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.213235,0,3,partial,1.7,0.1,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121101,TEX14,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.213235,0,3,partial,1.7,0.1,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121101,TEX14,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342424,0.296198,0.189068,0,3,partial,1.7,0.1,0.2,"bone marrow: 1.7 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121101,TEX14,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.5632% (minimum 99%, Missing); basal ganglia: 98.5632% (minimum 99%, Missing); bone marrow: 49.6382% (minimum 99%, Missing); choroid plexus: 97.7208% (minimum 99%, Missing); duodenum: 86.3980% (minimum 95%, Enhanced); heart muscle: 98.8473% (minimum 99%, Missing); hippocampal formation: 98.5632% (minimum 99%, Missing); hypothalamus: 98.8473% (minimum 99%, Missing); lymph node: 63.2841% (minimum 97%, Missing); midbrain: 98.0000% (minimum 99%, Missing); rectum: 79.2148% (minimum 97%, Missing); retina: 95.2778% (minimum 99%, Missing); skin: 88.1748% (minimum 95%, Missing); small intestine: 85.1117% (minimum 95%, Enhanced); smooth muscle: 92.7027% (minimum 95%, Enhanced); spinal cord: 97.4432% (minimum 99%, Missing); spleen: 90.5013% (minimum 95%, Missing); stomach: 90.7407% (minimum 97%, Missing); thymus: 48.5149% (minimum 95%, Missing); urinary bladder: 93.2065% (minimum 97%, Missing)",-0.464851,-0.337159,-0.493618,0,5,partial,34.8,19.9,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 2); rectum: 9 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121152,NCAPH,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 49.6382% (minimum 75%, Missing); lymph node: 63.2841% (minimum 70%, Missing); thymus: 48.5149% (minimum 65%, Missing)",-0.164851,-0.0671587,-0.253618,0,5,partial,34.8,19.9,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 2); rectum: 9 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121152,NCAPH,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 49.6382% (minimum 75%, Missing); lymph node: 63.2841% (minimum 70%, Missing); thymus: 48.5149% (minimum 65%, Missing)",-0.164851,-0.0671587,-0.253618,0,5,partial,34.8,19.9,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 3); rectum: 9 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); retina: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121152,NCAPH,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 49.6382% (minimum 75%, Missing); lymph node: 63.2841% (minimum 70%, Missing); thymus: 48.5149% (minimum 65%, Missing)",-0.164851,-0.0671587,-0.253618,0,5,partial,34.8,19.9,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 3); rectum: 9 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); retina: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121152,NCAPH,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 49.6382% (minimum 75%, Baseline (adaptation disabled)); lymph node: 63.2841% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.5149% (minimum 65%, Baseline (adaptation disabled))",-0.164851,-0.0671587,-0.253618,0,5,partial,34.8,19.9,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 3); rectum: 9 nTPM (protected, limit 3); colon: 7.4 nTPM (protected, limit 3); esophagus: 6.2 nTPM (protected, limit 3); small intestine: 6 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121152,NCAPH,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 80.0000% (minimum 99%, Missing); amygdala: 61.5385% (minimum 99%, Missing); basal ganglia: 42.1053% (minimum 99%, Missing); bone marrow: 61.5385% (minimum 99%, Missing); cerebellum: 88.8889% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 42.1053% (minimum 99%, Missing); heart muscle: 88.8889% (minimum 99%, Missing); hippocampal formation: 57.1429% (minimum 99%, Missing); hypothalamus: 38.0952% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 27.5862% (minimum 99%, Missing); lung: 72.7273% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 50.0000% (minimum 99%, Missing); parathyroid gland: 80.0000% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 47.0588% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); skeletal muscle: 50.0000% (minimum 99%, Missing); skin: 72.7273% (minimum 95%, Missing); small intestine: 34.7826% (minimum 99%, Missing); spinal cord: 32.0000% (minimum 99%, Missing); spleen: 88.8889% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thyroid gland: 34.7826% (minimum 95%, Missing); urinary bladder: 88.8889% (minimum 97%, Missing)",-0.602174,-0.354615,-0.714138,0,80,unavailable,2.1,0.5,1.5,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121207,LRAT,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 61.5385% (minimum 75%, Missing); basal ganglia: 42.1053% (minimum 75%, Missing); bone marrow: 61.5385% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 42.1053% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 38.0952% (minimum 75%, Missing); liver: 27.5862% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); retina: 47.0588% (minimum 75%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); small intestine: 34.7826% (minimum 75%, Missing); spinal cord: 32.0000% (minimum 75%, Missing); thyroid gland: 34.7826% (minimum 65%, Missing)",-0.302174,-0.0846154,-0.474138,0,80,unavailable,2.1,0.5,1.5,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121207,LRAT,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 61.5385% (minimum 75%, Missing); basal ganglia: 42.1053% (minimum 75%, Missing); bone marrow: 61.5385% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 42.1053% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 38.0952% (minimum 75%, Missing); liver: 27.5862% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); retina: 47.0588% (minimum 75%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); small intestine: 34.7826% (minimum 75%, Missing); spinal cord: 32.0000% (minimum 75%, Missing); thyroid gland: 34.7826% (minimum 65%, Missing)",-0.302174,-0.0846154,-0.474138,0,80,unavailable,2.1,0.5,1.5,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121207,LRAT,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 61.5385% (minimum 75%, Missing); basal ganglia: 42.1053% (minimum 75%, Missing); bone marrow: 61.5385% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 42.1053% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 38.0952% (minimum 75%, Missing); liver: 27.5862% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); retina: 47.0588% (minimum 75%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); small intestine: 34.7826% (minimum 75%, Missing); spinal cord: 32.0000% (minimum 75%, Missing); thyroid gland: 34.7826% (minimum 65%, Missing)",-0.302174,-0.0846154,-0.474138,0,80,unavailable,2.1,0.5,1.5,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121207,LRAT,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 61.5385% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 42.1053% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.5385% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 70%, Baseline (adaptation disabled)); duodenum: 42.1053% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.1429% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 38.0952% (minimum 75%, Baseline (adaptation disabled)); liver: 27.5862% (minimum 75%, Baseline (adaptation disabled)); lung: 72.7273% (minimum 75%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 50.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 47.0588% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 50.0000% (minimum 75%, Baseline (adaptation disabled)); small intestine: 34.7826% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 32.0000% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 34.7826% (minimum 65%, Baseline (adaptation disabled))",-0.302174,-0.0846154,-0.474138,0,80,unavailable,2.1,0.5,1.5,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121207,LRAT,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.8553% (minimum 97%, Supported); amygdala: 94.4785% (minimum 99%, Missing); basal ganglia: 94.4785% (minimum 99%, Missing); bone marrow: 54.0351% (minimum 99%, Missing); cerebral cortex: 95.6522% (minimum 97%, Supported); colon: 78.1726% (minimum 90%, Supported); duodenum: 84.1530% (minimum 97%, Supported); esophagus: 82.7957% (minimum 90%, Supported); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 93.9024% (minimum 99%, Missing); kidney: 96.2500% (minimum 97%, Supported); liver: 92.7711% (minimum 97%, Supported); lung: 95.6522% (minimum 99%, Missing); lymph node: 56.8266% (minimum 97%, Missing); midbrain: 92.7711% (minimum 99%, Missing); pituitary gland: 98.0892% (minimum 99%, Missing); rectum: 75.8621% (minimum 90%, Supported); skeletal muscle: 92.7711% (minimum 97%, Supported); small intestine: 86.0335% (minimum 97%, Supported); smooth muscle: 91.6667% (minimum 97%, Supported); spinal cord: 91.1243% (minimum 99%, Missing); spleen: 90.0585% (minimum 95%, Missing); thymus: 37.1981% (minimum 95%, Missing); tongue: 96.8553% (minimum 97%, Missing)",-0.578019,-0.401734,-0.449649,0,3,partial,13.1,11.7,26,"thymus: 26 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); thymus / cortical cells: High (Supported); thymus / medullary cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121211,MND1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 54.0351% (minimum 75%, Missing); lymph node: 56.8266% (minimum 70%, Missing); thymus: 37.1981% (minimum 65%, Missing)",-0.278019,-0.131734,-0.209649,0,3,partial,13.1,11.7,26,"thymus: 26 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); thymus / cortical cells: High (Supported); thymus / medullary cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121211,MND1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 54.0351% (minimum 75%, Missing); lymph node: 56.8266% (minimum 70%, Missing); thymus: 37.1981% (minimum 65%, Missing)",-0.278019,-0.131734,-0.209649,0,3,partial,13.1,11.7,26,"thymus: 26 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 3); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); thymus / cortical cells: High (Supported); thymus / medullary cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121211,MND1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 54.0351% (minimum 75%, Missing); lymph node: 56.8266% (minimum 70%, Missing); thymus: 37.1981% (minimum 65%, Missing)",-0.278019,-0.131734,-0.209649,0,3,partial,13.1,11.7,26,"thymus: 26 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 3); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); thymus / cortical cells: High (Supported); thymus / medullary cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121211,MND1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 54.0351% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.8266% (minimum 70%, Baseline (adaptation disabled)); thymus: 37.1981% (minimum 65%, Baseline (adaptation disabled))",-0.278019,-0.131734,-0.209649,0,3,partial,13.1,11.7,26,"thymus: 26 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 3); rectum: 4.9 nTPM (protected, limit 3); colon: 4.3 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); thymus / cortical cells: High (Supported); thymus / medullary cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121211,MND1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 96.5885% (minimum 99%, Missing)",0.0434211,0.03,-0.0241151,0,80,unavailable,1.6,0,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121270,ABCC11,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343421,0.3,0.215885,0,80,unavailable,1.6,0,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121270,ABCC11,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343421,0.3,0.215885,0,80,unavailable,1.6,0,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121270,ABCC11,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343421,0.3,0.215885,0,80,unavailable,1.6,0,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121270,ABCC11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343421,0.3,0.215885,0,80,unavailable,1.6,0,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121270,ABCC11,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 74.5721% (minimum 80%, Enhanced); duodenum: 69.6347% (minimum 99%, Missing); lymph node: 95.9119% (minimum 97%, Missing); pancreas: 85.4342% (minimum 95%, Enhanced); rectum: 67.0330% (minimum 80%, Enhanced); small intestine: 70.9302% (minimum 99%, Missing); stomach: 77.0202% (minimum 80%, Enhanced)",0.0121451,-0.12967,-0.293653,0,4,partial,13.3,15,1.2,"rectum: 15 nTPM (protected, limit 12); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121380,BCL2L14,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 69.6347% (minimum 75%, Missing); small intestine: 70.9302% (minimum 75%, Missing)",0.312145,0.12033,-0.053653,0,4,partial,13.3,15,1.2,"rectum: 15 nTPM (protected, limit 12); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121380,BCL2L14,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 69.6347% (minimum 75%, Missing); small intestine: 70.9302% (minimum 75%, Missing)",0.312145,0.12033,-0.053653,0,4,partial,13.3,15,1.2,"rectum: 15 nTPM (protected, limit 12); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121380,BCL2L14,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 69.6347% (minimum 75%, Missing); small intestine: 70.9302% (minimum 75%, Missing)",0.312145,0.12033,-0.053653,0,4,partial,13.3,15,1.2,"rectum: 15 nTPM (protected, limit 12); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121380,BCL2L14,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 69.6347% (minimum 75%, Baseline (adaptation disabled)); rectum: 67.0330% (minimum 70%, Baseline (adaptation disabled)); small intestine: 70.9302% (minimum 75%, Baseline (adaptation disabled))",0.312145,-0.0296703,-0.053653,0,4,partial,13.3,15,1.2,"rectum: 15 nTPM (protected, limit 3); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 3); stomach: 9.1 nTPM (protected, limit 3); pancreas: 5.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121380,BCL2L14,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.6275% (minimum 95%, Missing); adrenal gland: 65.8537% (minimum 99%, Missing); amygdala: 64.8000% (minimum 99%, Missing); basal ganglia: 64.2857% (minimum 99%, Missing); bone marrow: 31.3953% (minimum 99%, Missing); cerebellum: 56.2500% (minimum 99%, Missing); cerebral cortex: 55.2273% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 62.7907% (minimum 97%, Missing); duodenum: 66.7582% (minimum 99%, Missing); esophagus: 64.1161% (minimum 97%, Missing); heart muscle: 69.4286% (minimum 99%, Missing); hippocampal formation: 62.9534% (minimum 99%, Missing); hypothalamus: 61.6751% (minimum 99%, Missing); kidney: 67.3130% (minimum 99%, Missing); liver: 73.8602% (minimum 99%, Missing); lung: 71.6814% (minimum 99%, Missing); lymph node: 54.4843% (minimum 97%, Missing); midbrain: 68.8385% (minimum 99%, Missing); pancreas: 72.3214% (minimum 99%, Missing); parathyroid gland: 72.7545% (minimum 97%, Missing); pituitary gland: 70.6395% (minimum 99%, Missing); rectum: 61.8321% (minimum 97%, Missing); retina: 58.9806% (minimum 99%, Missing); salivary gland: 71.4706% (minimum 97%, Missing); skeletal muscle: 54.6067% (minimum 99%, Missing); skin: 63.4465% (minimum 95%, Missing); small intestine: 66.9421% (minimum 99%, Missing); smooth muscle: 66.5753% (minimum 99%, Missing); spinal cord: 69.8276% (minimum 99%, Missing); spleen: 69.0341% (minimum 95%, Missing); stomach: 67.5000% (minimum 97%, Missing); thymus: 51.9231% (minimum 95%, Missing); thyroid gland: 67.1271% (minimum 95%, Missing); tongue: 66.3934% (minimum 97%, Missing); urinary bladder: 55.2273% (minimum 97%, Missing)",-0.430769,-0.425157,-0.676047,0,4,partial,53.1,20.3,22.5,"bone marrow: 53.1 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); lymph node: 20.3 nTPM (protected, limit 2); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 2); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 2); colon: 14.4 nTPM (protected, limit 2); hippocampal formation: 14.3 nTPM (vital, limit 1); skin: 14 nTPM (manageable, limit 5); esophagus: 13.6 nTPM (protected, limit 2); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 2); midbrain: 11 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (manageable, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 2); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 2); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121390,PSPC1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.8537% (minimum 75%, Missing); amygdala: 64.8000% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); bone marrow: 31.3953% (minimum 75%, Missing); cerebellum: 56.2500% (minimum 75%, Missing); cerebral cortex: 55.2273% (minimum 75%, Missing); colon: 62.7907% (minimum 70%, Missing); duodenum: 66.7582% (minimum 75%, Missing); esophagus: 64.1161% (minimum 70%, Missing); heart muscle: 69.4286% (minimum 75%, Missing); hippocampal formation: 62.9534% (minimum 75%, Missing); hypothalamus: 61.6751% (minimum 75%, Missing); kidney: 67.3130% (minimum 75%, Missing); liver: 73.8602% (minimum 75%, Missing); lung: 71.6814% (minimum 75%, Missing); lymph node: 54.4843% (minimum 70%, Missing); midbrain: 68.8385% (minimum 75%, Missing); pancreas: 72.3214% (minimum 75%, Missing); pituitary gland: 70.6395% (minimum 75%, Missing); rectum: 61.8321% (minimum 70%, Missing); retina: 58.9806% (minimum 75%, Missing); skeletal muscle: 54.6067% (minimum 75%, Missing); skin: 63.4465% (minimum 65%, Missing); small intestine: 66.9421% (minimum 75%, Missing); smooth muscle: 66.5753% (minimum 75%, Missing); spinal cord: 69.8276% (minimum 75%, Missing); stomach: 67.5000% (minimum 70%, Missing); thymus: 51.9231% (minimum 65%, Missing); tongue: 66.3934% (minimum 70%, Missing); urinary bladder: 55.2273% (minimum 70%, Missing)",-0.130769,-0.155157,-0.436047,0,4,partial,53.1,20.3,22.5,"bone marrow: 53.1 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); lymph node: 20.3 nTPM (protected, limit 2); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 2); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 2); colon: 14.4 nTPM (protected, limit 2); hippocampal formation: 14.3 nTPM (vital, limit 1); skin: 14 nTPM (manageable, limit 5); esophagus: 13.6 nTPM (protected, limit 2); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 2); midbrain: 11 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (manageable, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 2); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 2); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121390,PSPC1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.8537% (minimum 75%, Missing); amygdala: 64.8000% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); bone marrow: 31.3953% (minimum 75%, Missing); cerebellum: 56.2500% (minimum 75%, Missing); cerebral cortex: 55.2273% (minimum 75%, Missing); colon: 62.7907% (minimum 70%, Missing); duodenum: 66.7582% (minimum 75%, Missing); esophagus: 64.1161% (minimum 70%, Missing); heart muscle: 69.4286% (minimum 75%, Missing); hippocampal formation: 62.9534% (minimum 75%, Missing); hypothalamus: 61.6751% (minimum 75%, Missing); kidney: 67.3130% (minimum 75%, Missing); liver: 73.8602% (minimum 75%, Missing); lung: 71.6814% (minimum 75%, Missing); lymph node: 54.4843% (minimum 70%, Missing); midbrain: 68.8385% (minimum 75%, Missing); pancreas: 72.3214% (minimum 75%, Missing); pituitary gland: 70.6395% (minimum 75%, Missing); rectum: 61.8321% (minimum 70%, Missing); retina: 58.9806% (minimum 75%, Missing); skeletal muscle: 54.6067% (minimum 75%, Missing); skin: 63.4465% (minimum 65%, Missing); small intestine: 66.9421% (minimum 75%, Missing); smooth muscle: 66.5753% (minimum 75%, Missing); spinal cord: 69.8276% (minimum 75%, Missing); stomach: 67.5000% (minimum 70%, Missing); thymus: 51.9231% (minimum 65%, Missing); tongue: 66.3934% (minimum 70%, Missing); urinary bladder: 55.2273% (minimum 70%, Missing)",-0.130769,-0.155157,-0.436047,0,4,partial,53.1,20.3,22.5,"bone marrow: 53.1 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); lymph node: 20.3 nTPM (protected, limit 3); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 3); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 3); colon: 14.4 nTPM (protected, limit 3); hippocampal formation: 14.3 nTPM (vital, limit 1); skin: 14 nTPM (manageable, limit 5); esophagus: 13.6 nTPM (protected, limit 3); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 3); midbrain: 11 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (manageable, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 3); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 3); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121390,PSPC1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.8537% (minimum 75%, Missing); amygdala: 64.8000% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); bone marrow: 31.3953% (minimum 75%, Missing); cerebellum: 56.2500% (minimum 75%, Missing); cerebral cortex: 55.2273% (minimum 75%, Missing); colon: 62.7907% (minimum 70%, Missing); duodenum: 66.7582% (minimum 75%, Missing); esophagus: 64.1161% (minimum 70%, Missing); heart muscle: 69.4286% (minimum 75%, Missing); hippocampal formation: 62.9534% (minimum 75%, Missing); hypothalamus: 61.6751% (minimum 75%, Missing); kidney: 67.3130% (minimum 75%, Missing); liver: 73.8602% (minimum 75%, Missing); lung: 71.6814% (minimum 75%, Missing); lymph node: 54.4843% (minimum 70%, Missing); midbrain: 68.8385% (minimum 75%, Missing); pancreas: 72.3214% (minimum 75%, Missing); pituitary gland: 70.6395% (minimum 75%, Missing); rectum: 61.8321% (minimum 70%, Missing); retina: 58.9806% (minimum 75%, Missing); skeletal muscle: 54.6067% (minimum 75%, Missing); skin: 63.4465% (minimum 65%, Missing); small intestine: 66.9421% (minimum 75%, Missing); smooth muscle: 66.5753% (minimum 75%, Missing); spinal cord: 69.8276% (minimum 75%, Missing); stomach: 67.5000% (minimum 70%, Missing); thymus: 51.9231% (minimum 65%, Missing); tongue: 66.3934% (minimum 70%, Missing); urinary bladder: 55.2273% (minimum 70%, Missing)",-0.130769,-0.155157,-0.436047,0,4,partial,53.1,20.3,22.5,"bone marrow: 53.1 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); lymph node: 20.3 nTPM (protected, limit 3); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 3); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 3); colon: 14.4 nTPM (protected, limit 3); hippocampal formation: 14.3 nTPM (vital, limit 1); skin: 14 nTPM (manageable, limit 5); esophagus: 13.6 nTPM (protected, limit 3); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 3); midbrain: 11 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (manageable, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 3); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 3); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121390,PSPC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.8537% (minimum 75%, Baseline (adaptation disabled)); amygdala: 64.8000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.2857% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 31.3953% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.2500% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 55.2273% (minimum 75%, Baseline (adaptation disabled)); colon: 62.7907% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.7582% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.1161% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.4286% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 62.9534% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.6751% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.3130% (minimum 75%, Baseline (adaptation disabled)); liver: 73.8602% (minimum 75%, Baseline (adaptation disabled)); lung: 71.6814% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.4843% (minimum 70%, Baseline (adaptation disabled)); midbrain: 68.8385% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.3214% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 70.6395% (minimum 75%, Baseline (adaptation disabled)); rectum: 61.8321% (minimum 70%, Baseline (adaptation disabled)); retina: 58.9806% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 54.6067% (minimum 75%, Baseline (adaptation disabled)); skin: 63.4465% (minimum 65%, Baseline (adaptation disabled)); small intestine: 66.9421% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.5753% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.8276% (minimum 75%, Baseline (adaptation disabled)); stomach: 67.5000% (minimum 70%, Baseline (adaptation disabled)); thymus: 51.9231% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.3934% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 55.2273% (minimum 70%, Baseline (adaptation disabled))",-0.130769,-0.155157,-0.436047,0,4,partial,53.1,20.3,22.5,"bone marrow: 53.1 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); lymph node: 20.3 nTPM (protected, limit 3); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 3); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 3); colon: 14.4 nTPM (protected, limit 3); hippocampal formation: 14.3 nTPM (vital, limit 1); skin: 14 nTPM (manageable, limit 5); esophagus: 13.6 nTPM (protected, limit 3); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 3); midbrain: 11 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (manageable, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 3); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 3); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121390,PSPC1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.01,0.03,0.01,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121446,RGSL1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121446,RGSL1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121446,RGSL1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121446,RGSL1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121446,RGSL1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 93.1818% (minimum 99%, Missing); bone marrow: 46.5909% (minimum 95%, Enhanced); liver: 87.2340% (minimum 95%, Enhanced); lung: 93.1818% (minimum 95%, Enhanced); pituitary gland: 87.2340% (minimum 99%, Missing); thymus: 25.3086% (minimum 95%, Missing)",-0.696914,0.03,-0.484091,0,2,partial,4.7,0.5,12.1,"thymus: 12.1 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121570,DPPA4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 46.5909% (minimum 60%, Enhanced); thymus: 25.3086% (minimum 65%, Missing)",-0.396914,0.3,-0.134091,0,2,partial,4.7,0.5,12.1,"thymus: 12.1 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121570,DPPA4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 46.5909% (minimum 60%, Enhanced); thymus: 25.3086% (minimum 65%, Missing)",-0.396914,0.3,-0.134091,0,2,partial,4.7,0.5,12.1,"thymus: 12.1 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121570,DPPA4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 46.5909% (minimum 60%, Enhanced); thymus: 25.3086% (minimum 65%, Missing)",-0.396914,0.3,-0.134091,0,2,partial,4.7,0.5,12.1,"thymus: 12.1 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121570,DPPA4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 46.5909% (minimum 75%, Baseline (adaptation disabled)); thymus: 25.3086% (minimum 65%, Baseline (adaptation disabled))",-0.396914,0.191304,-0.284091,0,2,partial,4.7,0.5,12.1,"thymus: 12.1 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121570,DPPA4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.1495% (minimum 99%, Missing); colon: 89.8649% (minimum 97%, Missing); duodenum: 90.4762% (minimum 99%, Missing); esophagus: 91.0959% (minimum 97%, Missing); kidney: 97.7941% (minimum 99%, Missing); liver: 97.7941% (minimum 99%, Missing); lung: 93.0070% (minimum 99%, Missing); lymph node: 74.7191% (minimum 97%, Missing); rectum: 86.9281% (minimum 97%, Missing); retina: 95.6835% (minimum 99%, Missing); skin: 91.7241% (minimum 95%, Missing); small intestine: 91.0959% (minimum 99%, Missing); smooth muscle: 95.0000% (minimum 99%, Missing); spinal cord: 98.5185% (minimum 99%, Missing); stomach: 95.6835% (minimum 97%, Missing); thymus: 58.8496% (minimum 95%, Missing); thyroid gland: 92.3611% (minimum 95%, Missing); urinary bladder: 95.0000% (minimum 97%, Missing)",-0.361504,-0.222809,-0.368505,0,4,partial,8.1,4.5,9.3,"thymus: 9.3 nTPM (manageable, limit 5); bone marrow: 8.1 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121621,KIF18A,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.1495% (minimum 75%, Missing); thymus: 58.8496% (minimum 65%, Missing)",-0.0615044,0.047191,-0.128505,0,4,partial,8.1,4.5,9.3,"thymus: 9.3 nTPM (manageable, limit 5); bone marrow: 8.1 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121621,KIF18A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.1495% (minimum 75%, Missing); thymus: 58.8496% (minimum 65%, Missing)",-0.0615044,0.047191,-0.128505,0,4,partial,8.1,4.5,9.3,"thymus: 9.3 nTPM (manageable, limit 5); bone marrow: 8.1 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121621,KIF18A,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.1495% (minimum 75%, Missing); thymus: 58.8496% (minimum 65%, Missing)",-0.0615044,0.047191,-0.128505,0,4,partial,8.1,4.5,9.3,"thymus: 9.3 nTPM (manageable, limit 5); bone marrow: 8.1 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121621,KIF18A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.1495% (minimum 75%, Baseline (adaptation disabled)); thymus: 58.8496% (minimum 65%, Baseline (adaptation disabled))",-0.0615044,0.047191,-0.128505,0,4,partial,8.1,4.5,9.3,"thymus: 9.3 nTPM (manageable, limit 5); bone marrow: 8.1 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121621,KIF18A,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.01,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: Medium (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121634,GJA8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: Medium (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121634,GJA8,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: Medium (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121634,GJA8,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: Medium (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121634,GJA8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.232759,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: Medium (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121634,GJA8,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.1631% (minimum 99%, Missing); amygdala: 91.9463% (minimum 99%, Missing); basal ganglia: 93.1973% (minimum 99%, Missing); bone marrow: 94.1581% (minimum 99%, Missing); cerebellum: 98.9170% (minimum 99%, Missing); cerebral cortex: 92.8814% (minimum 99%, Missing); choroid plexus: 90.7285% (minimum 99%, Missing); colon: 86.1635% (minimum 97%, Missing); duodenum: 53.4113% (minimum 99%, Missing); esophagus: 86.4353% (minimum 97%, Missing); heart muscle: 96.4789% (minimum 99%, Missing); hippocampal formation: 89.2508% (minimum 99%, Missing); hypothalamus: 93.8356% (minimum 99%, Missing); kidney: 59.3074% (minimum 99%, Missing); liver: 27.6210% (minimum 99%, Missing); lung: 96.8198% (minimum 99%, Missing); midbrain: 90.7285% (minimum 99%, Missing); pancreas: 88.1029% (minimum 99%, Missing); parathyroid gland: 92.5676% (minimum 97%, Missing); pituitary gland: 97.1631% (minimum 99%, Missing); rectum: 84.5679% (minimum 97%, Missing); salivary gland: 93.5154% (minimum 97%, Missing); skeletal muscle: 85.3583% (minimum 99%, Missing); skin: 82.5301% (minimum 95%, Missing); small intestine: 49.2806% (minimum 99%, Missing); smooth muscle: 94.4828% (minimum 99%, Missing); spinal cord: 85.8934% (minimum 99%, Missing); stomach: 90.4290% (minimum 97%, Missing); thymus: 90.7285% (minimum 95%, Missing); tongue: 96.8198% (minimum 97%, Missing); urinary bladder: 96.1404% (minimum 97%, Missing)",-0.124699,-0.124321,-0.71379,0,80,unavailable,71.8,5,5.8,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121690,DEPDC7,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 53.4113% (minimum 75%, Missing); kidney: 59.3074% (minimum 75%, Missing); liver: 27.6210% (minimum 75%, Missing); small intestine: 49.2806% (minimum 75%, Missing)",0.175301,0.145679,-0.47379,0,80,unavailable,71.8,5,5.8,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121690,DEPDC7,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 53.4113% (minimum 75%, Missing); kidney: 59.3074% (minimum 75%, Missing); liver: 27.6210% (minimum 75%, Missing); small intestine: 49.2806% (minimum 75%, Missing)",0.175301,0.145679,-0.47379,0,80,unavailable,71.8,5,5.8,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121690,DEPDC7,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 53.4113% (minimum 75%, Missing); kidney: 59.3074% (minimum 75%, Missing); liver: 27.6210% (minimum 75%, Missing); small intestine: 49.2806% (minimum 75%, Missing)",0.175301,0.145679,-0.47379,0,80,unavailable,71.8,5,5.8,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121690,DEPDC7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 53.4113% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.3074% (minimum 75%, Baseline (adaptation disabled)); liver: 27.6210% (minimum 75%, Baseline (adaptation disabled)); small intestine: 49.2806% (minimum 75%, Baseline (adaptation disabled))",0.175301,0.145679,-0.47379,0,80,unavailable,71.8,5,5.8,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121690,DEPDC7,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Missing); adrenal gland: 70.3704% (minimum 99%, Missing); amygdala: 79.1667% (minimum 99%, Missing); basal ganglia: 76.0000% (minimum 99%, Missing); bone marrow: 90.4762% (minimum 99%, Missing); cerebellum: 67.8571% (minimum 99%, Missing); cerebral cortex: 67.8571% (minimum 99%, Missing); choroid plexus: 65.5172% (minimum 99%, Missing); colon: 65.5172% (minimum 97%, Missing); duodenum: 43.1818% (minimum 99%, Missing); esophagus: 70.3704% (minimum 97%, Missing); heart muscle: 51.3514% (minimum 99%, Uncertain); hippocampal formation: 79.1667% (minimum 99%, Missing); hypothalamus: 79.1667% (minimum 99%, Missing); kidney: 65.5172% (minimum 99%, Missing); liver: 79.1667% (minimum 99%, Missing); lung: 67.8571% (minimum 99%, Missing); lymph node: 76.0000% (minimum 97%, Missing); midbrain: 76.0000% (minimum 99%, Missing); pancreas: 70.3704% (minimum 99%, Missing); parathyroid gland: 43.1818% (minimum 97%, Missing); pituitary gland: 67.8571% (minimum 99%, Missing); rectum: 61.2903% (minimum 97%, Missing); retina: 54.2857% (minimum 99%, Missing); salivary gland: 67.8571% (minimum 97%, Missing); skeletal muscle: 63.3333% (minimum 99%, Missing); skin: 70.3704% (minimum 95%, Missing); small intestine: 61.2903% (minimum 99%, Missing); smooth muscle: 57.5758% (minimum 99%, Missing); spinal cord: 76.0000% (minimum 99%, Missing); spleen: 67.8571% (minimum 95%, Missing); stomach: 61.2903% (minimum 97%, Missing); thymus: 61.2903% (minimum 95%, Missing); thyroid gland: 61.2903% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 67.8571% (minimum 97%, Missing)",-0.337097,-0.538182,-0.558182,0,1,partial,2.5,2.5,1.2,"duodenum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121903,ZSCAN20,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.3704% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 75%, Missing); cerebral cortex: 67.8571% (minimum 75%, Missing); choroid plexus: 65.5172% (minimum 75%, Missing); colon: 65.5172% (minimum 70%, Missing); duodenum: 43.1818% (minimum 75%, Missing); heart muscle: 51.3514% (minimum 75%, Uncertain); kidney: 65.5172% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); pancreas: 70.3704% (minimum 75%, Missing); parathyroid gland: 43.1818% (minimum 70%, Missing); pituitary gland: 67.8571% (minimum 75%, Missing); rectum: 61.2903% (minimum 70%, Missing); retina: 54.2857% (minimum 75%, Missing); salivary gland: 67.8571% (minimum 70%, Missing); skeletal muscle: 63.3333% (minimum 75%, Missing); small intestine: 61.2903% (minimum 75%, Missing); smooth muscle: 57.5758% (minimum 75%, Missing); stomach: 61.2903% (minimum 70%, Missing); thymus: 61.2903% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.0370968,-0.268182,-0.318182,0,1,partial,2.5,2.5,1.2,"duodenum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121903,ZSCAN20,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.3704% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 75%, Missing); cerebral cortex: 67.8571% (minimum 75%, Missing); choroid plexus: 65.5172% (minimum 75%, Missing); colon: 65.5172% (minimum 70%, Missing); duodenum: 43.1818% (minimum 75%, Missing); heart muscle: 51.3514% (minimum 75%, Uncertain); kidney: 65.5172% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); pancreas: 70.3704% (minimum 75%, Missing); parathyroid gland: 43.1818% (minimum 70%, Missing); pituitary gland: 67.8571% (minimum 75%, Missing); rectum: 61.2903% (minimum 70%, Missing); retina: 54.2857% (minimum 75%, Missing); salivary gland: 67.8571% (minimum 70%, Missing); skeletal muscle: 63.3333% (minimum 75%, Missing); small intestine: 61.2903% (minimum 75%, Missing); smooth muscle: 57.5758% (minimum 75%, Missing); stomach: 61.2903% (minimum 70%, Missing); thymus: 61.2903% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.0370968,-0.268182,-0.318182,0,1,partial,2.5,2.5,1.2,"duodenum: 2.5 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121903,ZSCAN20,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.3704% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 75%, Missing); cerebral cortex: 67.8571% (minimum 75%, Missing); choroid plexus: 65.5172% (minimum 75%, Missing); colon: 65.5172% (minimum 70%, Missing); duodenum: 43.1818% (minimum 75%, Missing); heart muscle: 51.3514% (minimum 75%, Uncertain); kidney: 65.5172% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); pancreas: 70.3704% (minimum 75%, Missing); parathyroid gland: 43.1818% (minimum 70%, Missing); pituitary gland: 67.8571% (minimum 75%, Missing); rectum: 61.2903% (minimum 70%, Missing); retina: 54.2857% (minimum 75%, Missing); salivary gland: 67.8571% (minimum 70%, Missing); skeletal muscle: 63.3333% (minimum 75%, Missing); small intestine: 61.2903% (minimum 75%, Missing); smooth muscle: 57.5758% (minimum 75%, Missing); stomach: 61.2903% (minimum 70%, Missing); thymus: 61.2903% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.0370968,-0.268182,-0.318182,0,1,partial,2.5,2.5,1.2,"duodenum: 2.5 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121903,ZSCAN20,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.3704% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.8571% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 67.8571% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 65.5172% (minimum 75%, Baseline (adaptation disabled)); colon: 65.5172% (minimum 70%, Baseline (adaptation disabled)); duodenum: 43.1818% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 51.3514% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.5172% (minimum 75%, Baseline (adaptation disabled)); lung: 67.8571% (minimum 75%, Baseline (adaptation disabled)); pancreas: 70.3704% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 43.1818% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.8571% (minimum 75%, Baseline (adaptation disabled)); rectum: 61.2903% (minimum 70%, Baseline (adaptation disabled)); retina: 54.2857% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 67.8571% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 63.3333% (minimum 75%, Baseline (adaptation disabled)); small intestine: 61.2903% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.5758% (minimum 75%, Baseline (adaptation disabled)); stomach: 61.2903% (minimum 70%, Baseline (adaptation disabled)); thymus: 61.2903% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 61.2903% (minimum 65%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.8571% (minimum 70%, Baseline (adaptation disabled))",-0.0370968,-0.268182,-0.318182,0,1,partial,2.5,2.5,1.2,"duodenum: 2.5 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121903,ZSCAN20,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 42.8571% (minimum 99%, Missing); amygdala: 15.7895% (minimum 99%, Missing); basal ganglia: 10.7143% (minimum 99%, Missing); cerebellum: 13.6364% (minimum 99%, Missing); cerebral cortex: 11.5385% (minimum 99%, Missing); choroid plexus: 60.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 25.0000% (minimum 99%, Missing); esophagus: 75.0000% (minimum 97%, Missing); heart muscle: 60.0000% (minimum 99%, Missing); hippocampal formation: 13.6364% (minimum 99%, Missing); hypothalamus: 11.1111% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 17.6471% (minimum 99%, Missing); pancreas: 18.7500% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); retina: 27.2727% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); smooth muscle: 60.0000% (minimum 99%, Missing); spinal cord: 30.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); thyroid gland: 37.5000% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.575,-0.22,-0.882857,0,80,unavailable,2.5,0.1,0.5,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121904,CSMD2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 42.8571% (minimum 75%, Missing); amygdala: 15.7895% (minimum 75%, Missing); basal ganglia: 10.7143% (minimum 75%, Missing); cerebellum: 13.6364% (minimum 75%, Missing); cerebral cortex: 11.5385% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); duodenum: 25.0000% (minimum 75%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 13.6364% (minimum 75%, Missing); hypothalamus: 11.1111% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); midbrain: 17.6471% (minimum 75%, Missing); pancreas: 18.7500% (minimum 75%, Missing); retina: 27.2727% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spinal cord: 30.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); thyroid gland: 37.5000% (minimum 65%, Missing)",-0.275,0.05,-0.642857,0,80,unavailable,2.5,0.1,0.5,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121904,CSMD2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 42.8571% (minimum 75%, Missing); amygdala: 15.7895% (minimum 75%, Missing); basal ganglia: 10.7143% (minimum 75%, Missing); cerebellum: 13.6364% (minimum 75%, Missing); cerebral cortex: 11.5385% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); duodenum: 25.0000% (minimum 75%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 13.6364% (minimum 75%, Missing); hypothalamus: 11.1111% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); midbrain: 17.6471% (minimum 75%, Missing); pancreas: 18.7500% (minimum 75%, Missing); retina: 27.2727% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spinal cord: 30.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); thyroid gland: 37.5000% (minimum 65%, Missing)",-0.275,0.05,-0.642857,0,80,unavailable,2.5,0.1,0.5,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121904,CSMD2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 42.8571% (minimum 75%, Missing); amygdala: 15.7895% (minimum 75%, Missing); basal ganglia: 10.7143% (minimum 75%, Missing); cerebellum: 13.6364% (minimum 75%, Missing); cerebral cortex: 11.5385% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); duodenum: 25.0000% (minimum 75%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 13.6364% (minimum 75%, Missing); hypothalamus: 11.1111% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); midbrain: 17.6471% (minimum 75%, Missing); pancreas: 18.7500% (minimum 75%, Missing); retina: 27.2727% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spinal cord: 30.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); thyroid gland: 37.5000% (minimum 65%, Missing)",-0.275,0.05,-0.642857,0,80,unavailable,2.5,0.1,0.5,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121904,CSMD2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 42.8571% (minimum 75%, Baseline (adaptation disabled)); amygdala: 15.7895% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 10.7143% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 13.6364% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 11.5385% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 25.0000% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 13.6364% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 11.1111% (minimum 75%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 17.6471% (minimum 75%, Baseline (adaptation disabled)); pancreas: 18.7500% (minimum 75%, Baseline (adaptation disabled)); retina: 27.2727% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 30.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 37.5000% (minimum 65%, Baseline (adaptation disabled))",-0.275,0.05,-0.642857,0,80,unavailable,2.5,0.1,0.5,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121904,CSMD2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.4872% (minimum 95%, Missing); adrenal gland: 70.4545% (minimum 99%, Missing); amygdala: 77.5000% (minimum 99%, Missing); basal ganglia: 73.8095% (minimum 99%, Missing); bone marrow: 75.6098% (minimum 99%, Missing); cerebellum: 83.7838% (minimum 99%, Missing); cerebral cortex: 72.0930% (minimum 99%, Missing); choroid plexus: 93.9394% (minimum 99%, Missing); colon: 81.5789% (minimum 97%, Missing); duodenum: 91.1765% (minimum 99%, Missing); esophagus: 83.7838% (minimum 97%, Missing); heart muscle: 77.5000% (minimum 99%, Missing); hippocampal formation: 77.5000% (minimum 99%, Missing); hypothalamus: 75.6098% (minimum 99%, Missing); kidney: 81.5789% (minimum 99%, Missing); liver: 75.6098% (minimum 99%, Missing); lung: 83.7838% (minimum 99%, Missing); lymph node: 86.1111% (minimum 97%, Missing); midbrain: 79.4872% (minimum 99%, Missing); pancreas: 72.0930% (minimum 99%, Missing); parathyroid gland: 86.1111% (minimum 97%, Missing); pituitary gland: 70.4545% (minimum 99%, Missing); rectum: 88.5714% (minimum 97%, Missing); retina: 70.4545% (minimum 99%, Missing); salivary gland: 83.7838% (minimum 97%, Missing); skeletal muscle: 62.0000% (minimum 99%, Missing); skin: 81.5789% (minimum 95%, Missing); small intestine: 83.7838% (minimum 99%, Missing); smooth muscle: 88.5714% (minimum 99%, Missing); spinal cord: 75.6098% (minimum 99%, Missing); spleen: 81.5789% (minimum 95%, Missing); stomach: 83.7838% (minimum 97%, Missing); thymus: 81.5789% (minimum 95%, Missing); thyroid gland: 75.6098% (minimum 95%, Missing); tongue: 83.7838% (minimum 97%, Missing); urinary bladder: 79.4872% (minimum 97%, Missing)",-0.193902,-0.175128,-0.37,0,80,unavailable,1.9,0.8,1,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121988,ZRANB3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.4545% (minimum 75%, Missing); basal ganglia: 73.8095% (minimum 75%, Missing); cerebral cortex: 72.0930% (minimum 75%, Missing); pancreas: 72.0930% (minimum 75%, Missing); pituitary gland: 70.4545% (minimum 75%, Missing); retina: 70.4545% (minimum 75%, Missing); skeletal muscle: 62.0000% (minimum 75%, Missing)",0.106098,0.0948718,-0.13,0,80,unavailable,1.9,0.8,1,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121988,ZRANB3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.4545% (minimum 75%, Missing); basal ganglia: 73.8095% (minimum 75%, Missing); cerebral cortex: 72.0930% (minimum 75%, Missing); pancreas: 72.0930% (minimum 75%, Missing); pituitary gland: 70.4545% (minimum 75%, Missing); retina: 70.4545% (minimum 75%, Missing); skeletal muscle: 62.0000% (minimum 75%, Missing)",0.106098,0.0948718,-0.13,0,80,unavailable,1.9,0.8,1,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121988,ZRANB3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.4545% (minimum 75%, Missing); basal ganglia: 73.8095% (minimum 75%, Missing); cerebral cortex: 72.0930% (minimum 75%, Missing); pancreas: 72.0930% (minimum 75%, Missing); pituitary gland: 70.4545% (minimum 75%, Missing); retina: 70.4545% (minimum 75%, Missing); skeletal muscle: 62.0000% (minimum 75%, Missing)",0.106098,0.0948718,-0.13,0,80,unavailable,1.9,0.8,1,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121988,ZRANB3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.4545% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.8095% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.0930% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.0930% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 70.4545% (minimum 75%, Baseline (adaptation disabled)); retina: 70.4545% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 62.0000% (minimum 75%, Baseline (adaptation disabled))",0.106098,0.0948718,-0.13,0,80,unavailable,1.9,0.8,1,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000121988,ZRANB3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"thyroid gland: 70.1299% (minimum 95%, Missing)",-0.248701,0.0118182,0.01,0,80,unavailable,0,0.2,4.6,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000122145,TBX22,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0512987,0.281818,0.25,0,80,unavailable,0,0.2,4.6,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000122145,TBX22,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0512987,0.281818,0.25,0,80,unavailable,0,0.2,4.6,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000122145,TBX22,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0512987,0.281818,0.25,0,80,unavailable,0,0.2,4.6,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000122145,TBX22,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0512987,0.281818,0.25,0,80,unavailable,0,0.2,4.6,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000122145,TBX22,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0499912,0.03,0.00985932,0,1,partial,4.5,2,3.5,"pituitary gland: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122304,PRM2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349991,0.3,0.249859,0,1,partial,4.5,2,3.5,"pituitary gland: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122304,PRM2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349991,0.3,0.249859,0,1,partial,4.5,2,3.5,"pituitary gland: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122304,PRM2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349991,0.3,0.249859,0,1,partial,4.5,2,3.5,"pituitary gland: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122304,PRM2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349692,0.299824,0.249604,0,1,partial,4.5,2,3.5,"skeletal muscle: 4.5 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122304,PRM2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 84.9462% (minimum 95%, Uncertain); adrenal gland: 89.7727% (minimum 99%, Missing); amygdala: 94.0476% (minimum 99%, Missing); basal ganglia: 90.8046% (minimum 99%, Missing); bone marrow: 55.6338% (minimum 99%, Missing); cerebellum: 90.8046% (minimum 99%, Missing); cerebral cortex: 91.8605% (minimum 99%, Missing); choroid plexus: 98.7500% (minimum 99%, Missing); colon: 84.9462% (minimum 97%, Missing); duodenum: 89.7727% (minimum 99%, Missing); esophagus: 86.8132% (minimum 97%, Missing); heart muscle: 89.7727% (minimum 99%, Missing); hippocampal formation: 94.0476% (minimum 99%, Missing); hypothalamus: 94.0476% (minimum 99%, Missing); kidney: 92.9412% (minimum 99%, Missing); liver: 84.0426% (minimum 99%, Missing); lung: 87.7778% (minimum 99%, Missing); lymph node: 58.5185% (minimum 97%, Missing); midbrain: 94.0476% (minimum 99%, Missing); pancreas: 95.1807% (minimum 99%, Missing); parathyroid gland: 96.3415% (minimum 97%, Missing); pituitary gland: 90.8046% (minimum 99%, Missing); rectum: 81.4433% (minimum 97%, Missing); retina: 96.3415% (minimum 99%, Missing); salivary gland: 91.8605% (minimum 97%, Uncertain); skeletal muscle: 80.6122% (minimum 99%, Missing); skin: 86.8132% (minimum 95%, Missing); small intestine: 84.0426% (minimum 99%, Missing); smooth muscle: 89.7727% (minimum 99%, Missing); spinal cord: 92.9412% (minimum 99%, Missing); spleen: 76.6990% (minimum 95%, Uncertain); stomach: 86.8132% (minimum 97%, Missing); thymus: 63.2000% (minimum 95%, Missing); thyroid gland: 91.8605% (minimum 95%, Missing); tongue: 95.1807% (minimum 97%, Missing); urinary bladder: 87.7778% (minimum 97%, Missing)",-0.318,-0.384815,-0.433662,0,3,partial,6.3,5.6,4.6,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 2); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122483,CCDC18,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.6338% (minimum 75%, Missing); lymph node: 58.5185% (minimum 70%, Missing); thymus: 63.2000% (minimum 65%, Missing)",-0.018,-0.114815,-0.193662,0,3,partial,6.3,5.6,4.6,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 2); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122483,CCDC18,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.6338% (minimum 75%, Missing); lymph node: 58.5185% (minimum 70%, Missing); thymus: 63.2000% (minimum 65%, Missing)",-0.018,-0.114815,-0.193662,0,3,partial,6.3,5.6,4.6,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 3); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122483,CCDC18,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.6338% (minimum 75%, Missing); lymph node: 58.5185% (minimum 70%, Missing); thymus: 63.2000% (minimum 65%, Missing)",-0.018,-0.114815,-0.193662,0,3,partial,6.3,5.6,4.6,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 3); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122483,CCDC18,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.6338% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.5185% (minimum 70%, Baseline (adaptation disabled)); thymus: 63.2000% (minimum 65%, Baseline (adaptation disabled))",-0.018,-0.114815,-0.193662,0,3,partial,6.3,5.6,4.6,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 3); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122483,CCDC18,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.6367% (minimum 95%, Missing); adrenal gland: 69.0878% (minimum 99%, Missing); amygdala: 74.0942% (minimum 99%, Missing); basal ganglia: 74.7715% (minimum 99%, Missing); bone marrow: 77.0245% (minimum 99%, Uncertain); cerebellum: 73.8267% (minimum 99%, Missing); cerebral cortex: 72.7758% (minimum 99%, Missing); choroid plexus: 84.1564% (minimum 99%, Missing); colon: 82.2938% (minimum 97%, Missing); duodenum: 84.5041% (minimum 99%, Missing); esophagus: 82.2938% (minimum 97%, Missing); heart muscle: 45.4950% (minimum 99%, Missing); hippocampal formation: 75.0459% (minimum 99%, Missing); hypothalamus: 72.2615% (minimum 99%, Missing); kidney: 78.0534% (minimum 99%, Missing); liver: 80.1961% (minimum 99%, Missing); lung: 84.6791% (minimum 99%, Missing); lymph node: 83.2994% (minimum 97%, Missing); midbrain: 73.5612% (minimum 99%, Missing); pancreas: 84.3299% (minimum 99%, Missing); parathyroid gland: 79.2636% (minimum 97%, Missing); pituitary gland: 85.2083% (minimum 99%, Missing); rectum: 84.3299% (minimum 97%, Missing); retina: 73.6937% (minimum 99%, Missing); salivary gland: 83.1301% (minimum 97%, Missing); skeletal muscle: 82.4597% (minimum 99%, Missing); skin: 79.5720% (minimum 95%, Missing); small intestine: 85.9244% (minimum 99%, Missing); smooth muscle: 80.1961% (minimum 99%, Uncertain); spinal cord: 75.0459% (minimum 99%, Missing); spleen: 83.9836% (minimum 95%, Uncertain); stomach: 86.8365% (minimum 97%, Missing); thymus: 77.1698% (minimum 95%, Missing); thyroid gland: 81.9639% (minimum 95%, Missing); tongue: 81.3121% (minimum 97%, Missing); urinary bladder: 82.7935% (minimum 97%, Missing)",-0.178302,-0.177364,-0.53505,0,2,partial,49,10.7,12.1,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); thymus: 12.1 nTPM (manageable, limit 5); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 2); skin: 10.5 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); liver: 10.1 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); thyroid gland: 9 nTPM (manageable, limit 5); esophagus: 8.8 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 2); salivary gland: 8.3 nTPM (protected, limit 2); lymph node: 8.2 nTPM (protected, limit 2); spleen: 7.8 nTPM (manageable, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 2); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122550,KLHL7,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0878% (minimum 75%, Missing); amygdala: 74.0942% (minimum 75%, Missing); basal ganglia: 74.7715% (minimum 75%, Missing); cerebellum: 73.8267% (minimum 75%, Missing); cerebral cortex: 72.7758% (minimum 75%, Missing); heart muscle: 45.4950% (minimum 75%, Missing); hypothalamus: 72.2615% (minimum 75%, Missing); midbrain: 73.5612% (minimum 75%, Missing); retina: 73.6937% (minimum 75%, Missing)",0.121698,0.0926357,-0.29505,0,2,partial,49,10.7,12.1,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); thymus: 12.1 nTPM (manageable, limit 5); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 2); skin: 10.5 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); liver: 10.1 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); thyroid gland: 9 nTPM (manageable, limit 5); esophagus: 8.8 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 2); salivary gland: 8.3 nTPM (protected, limit 2); lymph node: 8.2 nTPM (protected, limit 2); spleen: 7.8 nTPM (manageable, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 2); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122550,KLHL7,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0878% (minimum 75%, Missing); amygdala: 74.0942% (minimum 75%, Missing); basal ganglia: 74.7715% (minimum 75%, Missing); cerebellum: 73.8267% (minimum 75%, Missing); cerebral cortex: 72.7758% (minimum 75%, Missing); heart muscle: 45.4950% (minimum 75%, Missing); hypothalamus: 72.2615% (minimum 75%, Missing); midbrain: 73.5612% (minimum 75%, Missing); retina: 73.6937% (minimum 75%, Missing)",0.121698,0.0926357,-0.29505,0,2,partial,49,10.7,12.1,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); thymus: 12.1 nTPM (manageable, limit 5); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 3); skin: 10.5 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); liver: 10.1 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 3); adipose tissue: 9.2 nTPM (manageable, limit 5); thyroid gland: 9 nTPM (manageable, limit 5); esophagus: 8.8 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 3); salivary gland: 8.3 nTPM (protected, limit 3); lymph node: 8.2 nTPM (protected, limit 3); spleen: 7.8 nTPM (manageable, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 3); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122550,KLHL7,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0878% (minimum 75%, Missing); amygdala: 74.0942% (minimum 75%, Missing); basal ganglia: 74.7715% (minimum 75%, Missing); cerebellum: 73.8267% (minimum 75%, Missing); cerebral cortex: 72.7758% (minimum 75%, Missing); heart muscle: 45.4950% (minimum 75%, Missing); hypothalamus: 72.2615% (minimum 75%, Missing); midbrain: 73.5612% (minimum 75%, Missing); retina: 73.6937% (minimum 75%, Missing)",0.121698,0.0926357,-0.29505,0,2,partial,49,10.7,12.1,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); thymus: 12.1 nTPM (manageable, limit 5); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 3); skin: 10.5 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); liver: 10.1 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 3); adipose tissue: 9.2 nTPM (manageable, limit 5); thyroid gland: 9 nTPM (manageable, limit 5); esophagus: 8.8 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 3); salivary gland: 8.3 nTPM (protected, limit 3); lymph node: 8.2 nTPM (protected, limit 3); spleen: 7.8 nTPM (manageable, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 3); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122550,KLHL7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0878% (minimum 75%, Baseline (adaptation disabled)); amygdala: 74.0942% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.7715% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.8267% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.7758% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 45.4950% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.2615% (minimum 75%, Baseline (adaptation disabled)); midbrain: 73.5612% (minimum 75%, Baseline (adaptation disabled)); retina: 73.6937% (minimum 75%, Baseline (adaptation disabled))",0.121698,0.0926357,-0.29505,0,2,partial,49,10.7,12.1,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); thymus: 12.1 nTPM (manageable, limit 5); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 3); skin: 10.5 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); liver: 10.1 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 3); adipose tissue: 9.2 nTPM (manageable, limit 5); thyroid gland: 9 nTPM (manageable, limit 5); esophagus: 8.8 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 3); salivary gland: 8.3 nTPM (protected, limit 3); lymph node: 8.2 nTPM (protected, limit 3); spleen: 7.8 nTPM (manageable, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 3); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122550,KLHL7,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.8258% (minimum 95%, Missing); adrenal gland: 75.6614% (minimum 99%, Missing); amygdala: 71.1443% (minimum 99%, Missing); basal ganglia: 75.6614% (minimum 99%, Missing); bone marrow: 77.2973% (minimum 99%, Missing); cerebellum: 94.7020% (minimum 99%, Missing); cerebral cortex: 79.0055% (minimum 99%, Missing); choroid plexus: 80.3371% (minimum 99%, Missing); colon: 60.3376% (minimum 97%, Missing); duodenum: 60.8511% (minimum 99%, Missing); esophagus: 54.7893% (minimum 97%, Missing); heart muscle: 58.6066% (minimum 99%, Missing); hippocampal formation: 64.7059% (minimum 99%, Missing); hypothalamus: 76.4706% (minimum 99%, Missing); kidney: 76.0638% (minimum 99%, Missing); liver: 63.2743% (minimum 99%, Missing); lung: 51.8116% (minimum 99%, Missing); lymph node: 56.0784% (minimum 97%, Missing); midbrain: 71.5000% (minimum 99%, Missing); pancreas: 70.4433% (minimum 99%, Missing); parathyroid gland: 86.6667% (minimum 97%, Missing); pituitary gland: 74.8691% (minimum 99%, Missing); rectum: 77.2973% (minimum 97%, Missing); retina: 75.2632% (minimum 99%, Missing); salivary gland: 68.4211% (minimum 97%, Missing); skeletal muscle: 37.1429% (minimum 99%, Missing); skin: 74.8691% (minimum 95%, Missing); small intestine: 68.0952% (minimum 99%, Missing); smooth muscle: 56.0784% (minimum 99%, Missing); spinal cord: 72.5888% (minimum 99%, Missing); spleen: 55.4264% (minimum 95%, Missing); stomach: 76.4706% (minimum 97%, Missing); thymus: 77.7174% (minimum 95%, Missing); thyroid gland: 69.0821% (minimum 95%, Missing); tongue: 49.4810% (minimum 97%, Missing); urinary bladder: 61.3734% (minimum 97%, Missing)",-0.451742,-0.47519,-0.618571,0,6,partial,24.2,14.6,14.4,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 2); adipose tissue: 14.4 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 2); spleen: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 2); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 2); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); thyroid gland: 6.4 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); hypothalamus: 4.4 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122591,HYCC1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.8258% (minimum 65%, Missing); amygdala: 71.1443% (minimum 75%, Missing); colon: 60.3376% (minimum 70%, Missing); duodenum: 60.8511% (minimum 75%, Missing); esophagus: 54.7893% (minimum 70%, Missing); heart muscle: 58.6066% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); liver: 63.2743% (minimum 75%, Missing); lung: 51.8116% (minimum 75%, Missing); lymph node: 56.0784% (minimum 70%, Missing); midbrain: 71.5000% (minimum 75%, Missing); pancreas: 70.4433% (minimum 75%, Missing); pituitary gland: 74.8691% (minimum 75%, Missing); salivary gland: 68.4211% (minimum 70%, Missing); skeletal muscle: 37.1429% (minimum 75%, Missing); small intestine: 68.0952% (minimum 75%, Missing); smooth muscle: 56.0784% (minimum 75%, Missing); spinal cord: 72.5888% (minimum 75%, Missing); spleen: 55.4264% (minimum 65%, Missing); tongue: 49.4810% (minimum 70%, Missing); urinary bladder: 61.3734% (minimum 70%, Missing)",-0.151742,-0.20519,-0.378571,0,6,partial,24.2,14.6,14.4,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 2); adipose tissue: 14.4 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 2); spleen: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 2); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 2); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); thyroid gland: 6.4 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); hypothalamus: 4.4 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122591,HYCC1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.8258% (minimum 65%, Missing); amygdala: 71.1443% (minimum 75%, Missing); colon: 60.3376% (minimum 70%, Missing); duodenum: 60.8511% (minimum 75%, Missing); esophagus: 54.7893% (minimum 70%, Missing); heart muscle: 58.6066% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); liver: 63.2743% (minimum 75%, Missing); lung: 51.8116% (minimum 75%, Missing); lymph node: 56.0784% (minimum 70%, Missing); midbrain: 71.5000% (minimum 75%, Missing); pancreas: 70.4433% (minimum 75%, Missing); pituitary gland: 74.8691% (minimum 75%, Missing); salivary gland: 68.4211% (minimum 70%, Missing); skeletal muscle: 37.1429% (minimum 75%, Missing); small intestine: 68.0952% (minimum 75%, Missing); smooth muscle: 56.0784% (minimum 75%, Missing); spinal cord: 72.5888% (minimum 75%, Missing); spleen: 55.4264% (minimum 65%, Missing); tongue: 49.4810% (minimum 70%, Missing); urinary bladder: 61.3734% (minimum 70%, Missing)",-0.151742,-0.20519,-0.378571,0,6,partial,24.2,14.6,14.4,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 3); adipose tissue: 14.4 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 3); spleen: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 3); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 3); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); thyroid gland: 6.4 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); hypothalamus: 4.4 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122591,HYCC1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.8258% (minimum 65%, Missing); amygdala: 71.1443% (minimum 75%, Missing); colon: 60.3376% (minimum 70%, Missing); duodenum: 60.8511% (minimum 75%, Missing); esophagus: 54.7893% (minimum 70%, Missing); heart muscle: 58.6066% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); liver: 63.2743% (minimum 75%, Missing); lung: 51.8116% (minimum 75%, Missing); lymph node: 56.0784% (minimum 70%, Missing); midbrain: 71.5000% (minimum 75%, Missing); pancreas: 70.4433% (minimum 75%, Missing); pituitary gland: 74.8691% (minimum 75%, Missing); salivary gland: 68.4211% (minimum 70%, Missing); skeletal muscle: 37.1429% (minimum 75%, Missing); small intestine: 68.0952% (minimum 75%, Missing); smooth muscle: 56.0784% (minimum 75%, Missing); spinal cord: 72.5888% (minimum 75%, Missing); spleen: 55.4264% (minimum 65%, Missing); tongue: 49.4810% (minimum 70%, Missing); urinary bladder: 61.3734% (minimum 70%, Missing)",-0.151742,-0.20519,-0.378571,0,6,partial,24.2,14.6,14.4,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 3); adipose tissue: 14.4 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 3); spleen: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 3); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 3); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); thyroid gland: 6.4 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); hypothalamus: 4.4 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122591,HYCC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.8258% (minimum 65%, Baseline (adaptation disabled)); amygdala: 71.1443% (minimum 75%, Baseline (adaptation disabled)); colon: 60.3376% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.8511% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.7893% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.6066% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.7059% (minimum 75%, Baseline (adaptation disabled)); liver: 63.2743% (minimum 75%, Baseline (adaptation disabled)); lung: 51.8116% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.0784% (minimum 70%, Baseline (adaptation disabled)); midbrain: 71.5000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 70.4433% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 74.8691% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.4211% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 37.1429% (minimum 75%, Baseline (adaptation disabled)); small intestine: 68.0952% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.0784% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.5888% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.4264% (minimum 65%, Baseline (adaptation disabled)); tongue: 49.4810% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.3734% (minimum 70%, Baseline (adaptation disabled))",-0.151742,-0.20519,-0.378571,0,6,partial,24.2,14.6,14.4,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 3); adipose tissue: 14.4 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 3); spleen: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 3); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 3); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); thyroid gland: 6.4 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); hypothalamus: 4.4 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122591,HYCC1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 99%, Missing)",0.05,0.03,-0.49,0,80,unavailable,1.6,0,0,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122728,TAF1L,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1.6,0,0,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122728,TAF1L,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1.6,0,0,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122728,TAF1L,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1.6,0,0,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122728,TAF1L,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.25,0,80,unavailable,1.6,0,0,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122728,TAF1L,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.8305% (minimum 95%, Missing); adrenal gland: 75.7143% (minimum 99%, Missing); amygdala: 75.7143% (minimum 99%, Missing); basal ganglia: 73.6111% (minimum 99%, Missing); bone marrow: 94.6429% (minimum 99%, Missing); cerebellum: 89.8305% (minimum 99%, Missing); cerebral cortex: 55.7895% (minimum 99%, Missing); choroid plexus: 88.3333% (minimum 99%, Missing); colon: 86.8852% (minimum 97%, Missing); duodenum: 88.3333% (minimum 99%, Missing); esophagus: 91.3793% (minimum 97%, Missing); heart muscle: 82.8125% (minimum 99%, Missing); hippocampal formation: 72.6027% (minimum 99%, Missing); hypothalamus: 72.6027% (minimum 99%, Missing); kidney: 58.2418% (minimum 99%, Missing); liver: 92.9825% (minimum 99%, Missing); lung: 74.6479% (minimum 99%, Missing); midbrain: 80.3030% (minimum 99%, Missing); pancreas: 46.0870% (minimum 99%, Missing); parathyroid gland: 68.8312% (minimum 97%, Missing); pituitary gland: 75.7143% (minimum 99%, Missing); rectum: 88.3333% (minimum 97%, Missing); retina: 48.6239% (minimum 99%, Missing); salivary gland: 69.7368% (minimum 97%, Missing); skeletal muscle: 91.3793% (minimum 99%, Missing); skin: 86.8852% (minimum 95%, Missing); small intestine: 88.3333% (minimum 99%, Missing); smooth muscle: 81.5385% (minimum 99%, Missing); spinal cord: 85.4839% (minimum 99%, Missing); spleen: 94.6429% (minimum 95%, Missing); stomach: 80.3030% (minimum 97%, Missing); thymus: 69.7368% (minimum 95%, Missing); thyroid gland: 88.3333% (minimum 95%, Missing); tongue: 86.8852% (minimum 97%, Missing); urinary bladder: 82.8125% (minimum 97%, Missing)",-0.252632,-0.281688,-0.52913,0,3,partial,6.2,2.4,2.3,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122778,KIAA1549,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.6111% (minimum 75%, Missing); cerebral cortex: 55.7895% (minimum 75%, Missing); hippocampal formation: 72.6027% (minimum 75%, Missing); hypothalamus: 72.6027% (minimum 75%, Missing); kidney: 58.2418% (minimum 75%, Missing); lung: 74.6479% (minimum 75%, Missing); pancreas: 46.0870% (minimum 75%, Missing); parathyroid gland: 68.8312% (minimum 70%, Missing); retina: 48.6239% (minimum 75%, Missing); salivary gland: 69.7368% (minimum 70%, Missing)",0.0473684,-0.0116883,-0.28913,0,3,partial,6.2,2.4,2.3,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122778,KIAA1549,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.6111% (minimum 75%, Missing); cerebral cortex: 55.7895% (minimum 75%, Missing); hippocampal formation: 72.6027% (minimum 75%, Missing); hypothalamus: 72.6027% (minimum 75%, Missing); kidney: 58.2418% (minimum 75%, Missing); lung: 74.6479% (minimum 75%, Missing); pancreas: 46.0870% (minimum 75%, Missing); parathyroid gland: 68.8312% (minimum 70%, Missing); retina: 48.6239% (minimum 75%, Missing); salivary gland: 69.7368% (minimum 70%, Missing)",0.0473684,-0.0116883,-0.28913,0,3,partial,6.2,2.4,2.3,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122778,KIAA1549,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.6111% (minimum 75%, Missing); cerebral cortex: 55.7895% (minimum 75%, Missing); hippocampal formation: 72.6027% (minimum 75%, Missing); hypothalamus: 72.6027% (minimum 75%, Missing); kidney: 58.2418% (minimum 75%, Missing); lung: 74.6479% (minimum 75%, Missing); pancreas: 46.0870% (minimum 75%, Missing); parathyroid gland: 68.8312% (minimum 70%, Missing); retina: 48.6239% (minimum 75%, Missing); salivary gland: 69.7368% (minimum 70%, Missing)",0.0473684,-0.0116883,-0.28913,0,3,partial,6.2,2.4,2.3,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122778,KIAA1549,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.6111% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 55.7895% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.6027% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.6027% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.2418% (minimum 75%, Baseline (adaptation disabled)); lung: 74.6479% (minimum 75%, Baseline (adaptation disabled)); pancreas: 46.0870% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 68.8312% (minimum 70%, Baseline (adaptation disabled)); retina: 48.6239% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 69.7368% (minimum 70%, Baseline (adaptation disabled))",0.0473684,-0.0116883,-0.28913,0,3,partial,6.2,2.4,2.3,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000122778,KIAA1549,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123165,ACTRT1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123165,ACTRT1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123165,ACTRT1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123165,ACTRT1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123165,ACTRT1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123171,CCDC70,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123171,CCDC70,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123171,CCDC70,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123171,CCDC70,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123171,CCDC70,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3077% (minimum 95%, Missing); adrenal gland: 94.2857% (minimum 99%, Missing); amygdala: 97.0588% (minimum 99%, Missing); basal ganglia: 95.6522% (minimum 99%, Missing); bone marrow: 34.9206% (minimum 99%, Missing); cerebellum: 97.0588% (minimum 99%, Missing); cerebral cortex: 92.9577% (minimum 99%, Missing); choroid plexus: 97.7778% (minimum 99%, Missing); colon: 60.2740% (minimum 97%, Missing); duodenum: 61.9718% (minimum 99%, Missing); esophagus: 70.5882% (minimum 97%, Missing); heart muscle: 96.3504% (minimum 99%, Missing); hippocampal formation: 96.3504% (minimum 99%, Missing); hypothalamus: 97.0588% (minimum 99%, Missing); kidney: 94.2857% (minimum 99%, Missing); liver: 88.0000% (minimum 99%, Missing); lung: 86.8421% (minimum 99%, Missing); lymph node: 47.8261% (minimum 97%, Missing); midbrain: 96.3504% (minimum 99%, Missing); pancreas: 95.6522% (minimum 99%, Missing); parathyroid gland: 92.9577% (minimum 97%, Missing); pituitary gland: 97.7778% (minimum 99%, Missing); rectum: 53.4413% (minimum 97%, Missing); retina: 94.9640% (minimum 99%, Missing); salivary gland: 91.0345% (minimum 97%, Missing); skeletal muscle: 97.0588% (minimum 99%, Missing); skin: 60.8295% (minimum 95%, Missing); small intestine: 61.1111% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spinal cord: 95.6522% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 70.9677% (minimum 97%, Missing); thymus: 37.8223% (minimum 95%, Missing); thyroid gland: 91.6667% (minimum 95%, Missing); tongue: 96.3504% (minimum 97%, Missing); urinary bladder: 83.5443% (minimum 97%, Missing)",-0.571777,-0.491739,-0.640794,0,80,unavailable,24.6,14.4,21.7,"bone marrow: 24.6 nTPM (vital, limit 1); thymus: 21.7 nTPM (manageable, limit 5); lymph node: 14.4 nTPM (protected, limit 2); rectum: 11.5 nTPM (protected, limit 2); colon: 8.7 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123219,CENPK,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 34.9206% (minimum 75%, Missing); colon: 60.2740% (minimum 70%, Missing); duodenum: 61.9718% (minimum 75%, Missing); lymph node: 47.8261% (minimum 70%, Missing); rectum: 53.4413% (minimum 70%, Missing); skin: 60.8295% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); thymus: 37.8223% (minimum 65%, Missing)",-0.271777,-0.221739,-0.400794,0,80,unavailable,24.6,14.4,21.7,"bone marrow: 24.6 nTPM (vital, limit 1); thymus: 21.7 nTPM (manageable, limit 5); lymph node: 14.4 nTPM (protected, limit 2); rectum: 11.5 nTPM (protected, limit 2); colon: 8.7 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123219,CENPK,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 34.9206% (minimum 75%, Missing); colon: 60.2740% (minimum 70%, Missing); duodenum: 61.9718% (minimum 75%, Missing); lymph node: 47.8261% (minimum 70%, Missing); rectum: 53.4413% (minimum 70%, Missing); skin: 60.8295% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); thymus: 37.8223% (minimum 65%, Missing)",-0.271777,-0.221739,-0.400794,0,80,unavailable,24.6,14.4,21.7,"bone marrow: 24.6 nTPM (vital, limit 1); thymus: 21.7 nTPM (manageable, limit 5); lymph node: 14.4 nTPM (protected, limit 3); rectum: 11.5 nTPM (protected, limit 3); colon: 8.7 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123219,CENPK,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 34.9206% (minimum 75%, Missing); colon: 60.2740% (minimum 70%, Missing); duodenum: 61.9718% (minimum 75%, Missing); lymph node: 47.8261% (minimum 70%, Missing); rectum: 53.4413% (minimum 70%, Missing); skin: 60.8295% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); thymus: 37.8223% (minimum 65%, Missing)",-0.271777,-0.221739,-0.400794,0,80,unavailable,24.6,14.4,21.7,"bone marrow: 24.6 nTPM (vital, limit 1); thymus: 21.7 nTPM (manageable, limit 5); lymph node: 14.4 nTPM (protected, limit 3); rectum: 11.5 nTPM (protected, limit 3); colon: 8.7 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123219,CENPK,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 34.9206% (minimum 75%, Baseline (adaptation disabled)); colon: 60.2740% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.9718% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.8261% (minimum 70%, Baseline (adaptation disabled)); rectum: 53.4413% (minimum 70%, Baseline (adaptation disabled)); skin: 60.8295% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.1111% (minimum 75%, Baseline (adaptation disabled)); thymus: 37.8223% (minimum 65%, Baseline (adaptation disabled))",-0.271777,-0.221739,-0.400794,0,80,unavailable,24.6,14.4,21.7,"bone marrow: 24.6 nTPM (vital, limit 1); thymus: 21.7 nTPM (manageable, limit 5); lymph node: 14.4 nTPM (protected, limit 3); rectum: 11.5 nTPM (protected, limit 3); colon: 8.7 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123219,CENPK,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.3636% (minimum 95%, Missing); adrenal gland: 91.9355% (minimum 99%, Missing); amygdala: 91.9355% (minimum 99%, Missing); basal ganglia: 90.4762% (minimum 99%, Missing); bone marrow: 39.3103% (minimum 99%, Missing); cerebellum: 91.9355% (minimum 99%, Missing); cerebral cortex: 89.0625% (minimum 99%, Missing); choroid plexus: 93.4426% (minimum 99%, Missing); colon: 61.2903% (minimum 97%, Missing); duodenum: 68.6747% (minimum 99%, Missing); esophagus: 70.3704% (minimum 97%, Missing); heart muscle: 90.4762% (minimum 99%, Missing); hippocampal formation: 91.9355% (minimum 99%, Missing); hypothalamus: 93.4426% (minimum 99%, Missing); kidney: 89.0625% (minimum 99%, Missing); liver: 87.6923% (minimum 99%, Missing); lung: 87.6923% (minimum 99%, Missing); lymph node: 57.0000% (minimum 97%, Missing); midbrain: 91.9355% (minimum 99%, Missing); pancreas: 90.4762% (minimum 99%, Missing); parathyroid gland: 87.6923% (minimum 97%, Missing); pituitary gland: 95.0000% (minimum 99%, Missing); rectum: 51.8182% (minimum 97%, Missing); retina: 85.0746% (minimum 99%, Missing); salivary gland: 77.0270% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); skin: 67.0588% (minimum 95%, Missing); small intestine: 71.2500% (minimum 99%, Missing); smooth muscle: 81.4286% (minimum 99%, Missing); spinal cord: 91.9355% (minimum 99%, Missing); spleen: 80.2817% (minimum 95%, Missing); stomach: 76.0000% (minimum 97%, Missing); thymus: 39.8601% (minimum 95%, Missing); thyroid gland: 87.6923% (minimum 95%, Missing); tongue: 93.4426% (minimum 97%, Missing); urinary bladder: 85.0746% (minimum 97%, Missing)",-0.551399,-0.451818,-0.596897,0,80,unavailable,8.8,5.3,8.6,"bone marrow: 8.8 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); rectum: 5.3 nTPM (protected, limit 2); lymph node: 4.3 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123473,STIL,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 39.3103% (minimum 75%, Missing); colon: 61.2903% (minimum 70%, Missing); duodenum: 68.6747% (minimum 75%, Missing); lymph node: 57.0000% (minimum 70%, Missing); rectum: 51.8182% (minimum 70%, Missing); small intestine: 71.2500% (minimum 75%, Missing); thymus: 39.8601% (minimum 65%, Missing)",-0.251399,-0.181818,-0.356897,0,80,unavailable,8.8,5.3,8.6,"bone marrow: 8.8 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); rectum: 5.3 nTPM (protected, limit 2); lymph node: 4.3 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123473,STIL,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 39.3103% (minimum 75%, Missing); colon: 61.2903% (minimum 70%, Missing); duodenum: 68.6747% (minimum 75%, Missing); lymph node: 57.0000% (minimum 70%, Missing); rectum: 51.8182% (minimum 70%, Missing); small intestine: 71.2500% (minimum 75%, Missing); thymus: 39.8601% (minimum 65%, Missing)",-0.251399,-0.181818,-0.356897,0,80,unavailable,8.8,5.3,8.6,"bone marrow: 8.8 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); rectum: 5.3 nTPM (protected, limit 3); lymph node: 4.3 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); duodenum: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123473,STIL,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 39.3103% (minimum 75%, Missing); colon: 61.2903% (minimum 70%, Missing); duodenum: 68.6747% (minimum 75%, Missing); lymph node: 57.0000% (minimum 70%, Missing); rectum: 51.8182% (minimum 70%, Missing); small intestine: 71.2500% (minimum 75%, Missing); thymus: 39.8601% (minimum 65%, Missing)",-0.251399,-0.181818,-0.356897,0,80,unavailable,8.8,5.3,8.6,"bone marrow: 8.8 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); rectum: 5.3 nTPM (protected, limit 3); lymph node: 4.3 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); duodenum: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123473,STIL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 39.3103% (minimum 75%, Baseline (adaptation disabled)); colon: 61.2903% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.6747% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.0000% (minimum 70%, Baseline (adaptation disabled)); rectum: 51.8182% (minimum 70%, Baseline (adaptation disabled)); small intestine: 71.2500% (minimum 75%, Baseline (adaptation disabled)); thymus: 39.8601% (minimum 65%, Baseline (adaptation disabled))",-0.251399,-0.181818,-0.356897,0,80,unavailable,8.8,5.3,8.6,"bone marrow: 8.8 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); rectum: 5.3 nTPM (protected, limit 3); lymph node: 4.3 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); duodenum: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123473,STIL,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 94.7368% (minimum 95%, Missing); adrenal gland: 95.5752% (minimum 99%, Uncertain); bone marrow: 18.7500% (minimum 99%, Missing); cerebral cortex: 96.4286% (minimum 99%, Missing); choroid plexus: 97.2973% (minimum 99%, Missing); colon: 73.9726% (minimum 97%, Missing); duodenum: 73.4694% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Uncertain); heart muscle: 97.2973% (minimum 99%, Missing); kidney: 96.4286% (minimum 99%, Missing); liver: 93.1034% (minimum 99%, Missing); lung: 89.2562% (minimum 99%, Missing); lymph node: 46.7532% (minimum 97%, Missing); pancreas: 98.1818% (minimum 99%, Missing); rectum: 67.9245% (minimum 97%, Missing); salivary gland: 92.3077% (minimum 97%, Missing); skeletal muscle: 98.1818% (minimum 99%, Missing); skin: 75.5245% (minimum 95%, Uncertain); small intestine: 74.4828% (minimum 99%, Missing); smooth muscle: 85.0394% (minimum 99%, Missing); spleen: 72.9730% (minimum 95%, Missing); stomach: 82.4427% (minimum 97%, Missing); thymus: 26.7327% (minimum 95%, Missing); urinary bladder: 88.5246% (minimum 97%, Missing)",-0.682673,-0.502468,-0.8025,0,1,partial,46.8,12.3,29.6,"bone marrow: 46.8 nTPM (vital, limit 1); thymus: 29.6 nTPM (manageable, limit 5); lymph node: 12.3 nTPM (protected, limit 2); esophagus: 5.4 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123485,HJURP,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 18.7500% (minimum 75%, Missing); duodenum: 73.4694% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Uncertain); lymph node: 46.7532% (minimum 70%, Missing); rectum: 67.9245% (minimum 70%, Missing); small intestine: 74.4828% (minimum 75%, Missing); thymus: 26.7327% (minimum 65%, Missing)",-0.382673,-0.232468,-0.5625,0,1,partial,46.8,12.3,29.6,"bone marrow: 46.8 nTPM (vital, limit 1); thymus: 29.6 nTPM (manageable, limit 5); lymph node: 12.3 nTPM (protected, limit 2); esophagus: 5.4 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123485,HJURP,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 18.7500% (minimum 75%, Missing); duodenum: 73.4694% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Uncertain); lymph node: 46.7532% (minimum 70%, Missing); rectum: 67.9245% (minimum 70%, Missing); small intestine: 74.4828% (minimum 75%, Missing); thymus: 26.7327% (minimum 65%, Missing)",-0.382673,-0.232468,-0.5625,0,1,partial,46.8,12.3,29.6,"bone marrow: 46.8 nTPM (vital, limit 1); thymus: 29.6 nTPM (manageable, limit 5); lymph node: 12.3 nTPM (protected, limit 3); esophagus: 5.4 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123485,HJURP,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 18.7500% (minimum 75%, Missing); duodenum: 73.4694% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Uncertain); lymph node: 46.7532% (minimum 70%, Missing); rectum: 67.9245% (minimum 70%, Missing); small intestine: 74.4828% (minimum 75%, Missing); thymus: 26.7327% (minimum 65%, Missing)",-0.382673,-0.232468,-0.5625,0,1,partial,46.8,12.3,29.6,"bone marrow: 46.8 nTPM (vital, limit 1); thymus: 29.6 nTPM (manageable, limit 5); lymph node: 12.3 nTPM (protected, limit 3); esophagus: 5.4 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123485,HJURP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 18.7500% (minimum 75%, Baseline (adaptation disabled)); duodenum: 73.4694% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); lymph node: 46.7532% (minimum 70%, Baseline (adaptation disabled)); rectum: 67.9245% (minimum 70%, Baseline (adaptation disabled)); small intestine: 74.4828% (minimum 75%, Baseline (adaptation disabled)); thymus: 26.7327% (minimum 65%, Baseline (adaptation disabled))",-0.382673,-0.232468,-0.5625,0,1,partial,46.8,12.3,29.6,"bone marrow: 46.8 nTPM (vital, limit 1); thymus: 29.6 nTPM (manageable, limit 5); lymph node: 12.3 nTPM (protected, limit 3); esophagus: 5.4 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123485,HJURP,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 86.3501% (minimum 99%, Missing); amygdala: 91.2226% (minimum 99%, Missing); basal ganglia: 83.8617% (minimum 99%, Missing); cerebral cortex: 92.6752% (minimum 99%, Missing); choroid plexus: 76.9841% (minimum 99%, Missing); duodenum: 98.9796% (minimum 99%, Missing); heart muscle: 97.6510% (minimum 99%, Missing); hippocampal formation: 87.9154% (minimum 99%, Missing); hypothalamus: 71.3235% (minimum 99%, Missing); kidney: 89.2638% (minimum 99%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 95.7237% (minimum 99%, Missing); midbrain: 95.7237% (minimum 99%, Missing); pituitary gland: 71.3235% (minimum 99%, Missing); small intestine: 98.9796% (minimum 99%, Missing); smooth muscle: 98.9796% (minimum 99%, Missing); spinal cord: 98.6441% (minimum 99%, Missing); thymus: 93.2692% (minimum 95%, Missing); urinary bladder: 87.1257% (minimum 97%, Missing)",-0.0173077,-0.0987425,-0.276765,0,80,unavailable,11.7,4.3,2.1,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123496,IL13RA2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 71.3235% (minimum 75%, Missing); pituitary gland: 71.3235% (minimum 75%, Missing)",0.282692,0.171257,-0.0367647,0,80,unavailable,11.7,4.3,2.1,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123496,IL13RA2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 71.3235% (minimum 75%, Missing); pituitary gland: 71.3235% (minimum 75%, Missing)",0.282692,0.171257,-0.0367647,0,80,unavailable,11.7,4.3,2.1,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123496,IL13RA2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 71.3235% (minimum 75%, Missing); pituitary gland: 71.3235% (minimum 75%, Missing)",0.282692,0.171257,-0.0367647,0,80,unavailable,11.7,4.3,2.1,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123496,IL13RA2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 71.3235% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 71.3235% (minimum 75%, Baseline (adaptation disabled))",0.282692,0.171257,-0.0367647,0,80,unavailable,11.7,4.3,2.1,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123496,IL13RA2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2759% (minimum 99%, Missing); basal ganglia: 96.6102% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 98.2759% (minimum 99%, Missing); cerebral cortex: 87.6923% (minimum 99%, Missing); choroid plexus: 96.6102% (minimum 99%, Missing); colon: 96.6102% (minimum 97%, Missing); heart muscle: 95.0000% (minimum 99%, Missing); hippocampal formation: 98.2759% (minimum 99%, Missing); hypothalamus: 98.2759% (minimum 99%, Missing); kidney: 93.4426% (minimum 99%, Missing); liver: 96.6102% (minimum 99%, Missing); lung: 67.0588% (minimum 99%, Missing); lymph node: 91.9355% (minimum 97%, Missing); pancreas: 64.0449% (minimum 99%, Missing); parathyroid gland: 70.3704% (minimum 97%, Missing); pituitary gland: 95.0000% (minimum 99%, Missing); retina: 87.6923% (minimum 99%, Missing); salivary gland: 68.6747% (minimum 97%, Missing); skeletal muscle: 98.2759% (minimum 99%, Missing); skin: 93.4426% (minimum 95%, Missing); small intestine: 98.2759% (minimum 99%, Missing); smooth muscle: 91.9355% (minimum 99%, Missing); spinal cord: 98.2759% (minimum 99%, Missing); spleen: 70.3704% (minimum 95%, Missing); thyroid gland: 89.0625% (minimum 95%, Missing); urinary bladder: 96.6102% (minimum 97%, Missing)",-0.246296,-0.283253,-0.349551,0,80,unavailable,3.2,2.6,2.4,"pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.4 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123500,COL10A1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 67.0588% (minimum 75%, Missing); pancreas: 64.0449% (minimum 75%, Missing); salivary gland: 68.6747% (minimum 70%, Missing)",0.0537037,-0.013253,-0.109551,0,80,unavailable,3.2,2.6,2.4,"pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.4 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123500,COL10A1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 67.0588% (minimum 75%, Missing); pancreas: 64.0449% (minimum 75%, Missing); salivary gland: 68.6747% (minimum 70%, Missing)",0.0537037,-0.013253,-0.109551,0,80,unavailable,3.2,2.6,2.4,"pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123500,COL10A1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 67.0588% (minimum 75%, Missing); pancreas: 64.0449% (minimum 75%, Missing); salivary gland: 68.6747% (minimum 70%, Missing)",0.0537037,-0.013253,-0.109551,0,80,unavailable,3.2,2.6,2.4,"pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123500,COL10A1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 67.0588% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.0449% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.6747% (minimum 70%, Baseline (adaptation disabled))",0.0537037,-0.013253,-0.109551,0,80,unavailable,3.2,2.6,2.4,"pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123500,COL10A1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123569,H2BW1,admission_only,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123569,H2BW1,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123569,H2BW1,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123569,H2BW1,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123569,H2BW1,current_fixed,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123576,ESX1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123576,ESX1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123576,ESX1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123576,ESX1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123576,ESX1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123584,MAGEA9,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123584,MAGEA9,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123584,MAGEA9,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123584,MAGEA9,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123584,MAGEA9,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123594,ATXN3L,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123594,ATXN3L,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123594,ATXN3L,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123594,ATXN3L,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123594,ATXN3L,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.1889% (minimum 95%, Missing); adrenal gland: 69.2485% (minimum 99%, Missing); amygdala: 94.5055% (minimum 99%, Missing); basal ganglia: 94.9028% (minimum 99%, Missing); bone marrow: 50.8303% (minimum 99%, Missing); cerebellum: 95.2030% (minimum 99%, Missing); cerebral cortex: 94.6045% (minimum 99%, Missing); choroid plexus: 94.1606% (minimum 99%, Missing); colon: 80.9140% (minimum 97%, Missing); duodenum: 81.1321% (minimum 99%, Missing); esophagus: 77.7443% (minimum 97%, Missing); heart muscle: 94.8031% (minimum 99%, Missing); hippocampal formation: 94.4067% (minimum 99%, Missing); hypothalamus: 95.9617% (minimum 99%, Missing); kidney: 83.9219% (minimum 99%, Missing); liver: 85.6736% (minimum 99%, Missing); lung: 88.5728% (minimum 99%, Missing); lymph node: 64.2933% (minimum 97%, Missing); midbrain: 95.8090% (minimum 99%, Missing); pancreas: 97.7802% (minimum 99%, Missing); parathyroid gland: 90.4357% (minimum 97%, Missing); pituitary gland: 97.4636% (minimum 99%, Missing); rectum: 82.0163% (minimum 97%, Missing); retina: 86.9942% (minimum 99%, Missing); salivary gland: 94.5055% (minimum 97%, Missing); skeletal muscle: 95.2030% (minimum 99%, Missing); skin: 90.3452% (minimum 95%, Missing); small intestine: 84.9083% (minimum 99%, Missing); smooth muscle: 91.4430% (minimum 99%, Missing); spinal cord: 95.4545% (minimum 99%, Missing); spleen: 85.0282% (minimum 95%, Missing); stomach: 90.1198% (minimum 97%, Missing); thymus: 60.5228% (minimum 95%, Missing); thyroid gland: 93.5751% (minimum 95%, Missing); urinary bladder: 87.5849% (minimum 97%, Missing)",-0.344772,-0.327067,-0.481697,0,1,partial,174.7,100.3,117.8,"bone marrow: 174.7 nTPM (vital, limit 1); thymus: 117.8 nTPM (manageable, limit 5); lymph node: 100.3 nTPM (protected, limit 2); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 2); colon: 42.6 nTPM (protected, limit 2); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 2); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); spleen: 31.8 nTPM (manageable, limit 5); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 2); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 2); skin: 19.3 nTPM (manageable, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 2); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.4 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); salivary gland: 10.5 nTPM (protected, limit 2); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123975,CKS2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.2485% (minimum 75%, Missing); bone marrow: 50.8303% (minimum 75%, Missing); lymph node: 64.2933% (minimum 70%, Missing); thymus: 60.5228% (minimum 65%, Missing)",-0.0447721,-0.0570666,-0.241697,0,1,partial,174.7,100.3,117.8,"bone marrow: 174.7 nTPM (vital, limit 1); thymus: 117.8 nTPM (manageable, limit 5); lymph node: 100.3 nTPM (protected, limit 2); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 2); colon: 42.6 nTPM (protected, limit 2); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 2); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); spleen: 31.8 nTPM (manageable, limit 5); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 2); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 2); skin: 19.3 nTPM (manageable, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 2); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.4 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); salivary gland: 10.5 nTPM (protected, limit 2); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123975,CKS2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.2485% (minimum 75%, Missing); bone marrow: 50.8303% (minimum 75%, Missing); lymph node: 64.2933% (minimum 70%, Missing); thymus: 60.5228% (minimum 65%, Missing)",-0.0447721,-0.0570666,-0.241697,0,1,partial,174.7,100.3,117.8,"bone marrow: 174.7 nTPM (vital, limit 1); thymus: 117.8 nTPM (manageable, limit 5); lymph node: 100.3 nTPM (protected, limit 3); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 3); colon: 42.6 nTPM (protected, limit 3); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 3); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); spleen: 31.8 nTPM (manageable, limit 5); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 3); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 3); skin: 19.3 nTPM (manageable, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 3); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.4 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); salivary gland: 10.5 nTPM (protected, limit 3); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123975,CKS2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.2485% (minimum 75%, Missing); bone marrow: 50.8303% (minimum 75%, Missing); lymph node: 64.2933% (minimum 70%, Missing); thymus: 60.5228% (minimum 65%, Missing)",-0.0447721,-0.0570666,-0.241697,0,1,partial,174.7,100.3,117.8,"bone marrow: 174.7 nTPM (vital, limit 1); thymus: 117.8 nTPM (manageable, limit 5); lymph node: 100.3 nTPM (protected, limit 3); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 3); colon: 42.6 nTPM (protected, limit 3); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 3); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); spleen: 31.8 nTPM (manageable, limit 5); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 3); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 3); skin: 19.3 nTPM (manageable, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 3); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.4 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); salivary gland: 10.5 nTPM (protected, limit 3); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123975,CKS2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.2485% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 50.8303% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.2933% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.5228% (minimum 65%, Baseline (adaptation disabled))",-0.0447721,-0.0570666,-0.241697,0,1,partial,174.7,100.3,117.8,"bone marrow: 174.7 nTPM (vital, limit 1); thymus: 117.8 nTPM (manageable, limit 5); lymph node: 100.3 nTPM (protected, limit 3); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 3); colon: 42.6 nTPM (protected, limit 3); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 3); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); spleen: 31.8 nTPM (manageable, limit 5); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 3); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 3); skin: 19.3 nTPM (manageable, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 3); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.4 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); salivary gland: 10.5 nTPM (protected, limit 3); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123975,CKS2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2471% (minimum 99%, Missing); basal ganglia: 88.0492% (minimum 99%, Missing); cerebral cortex: 97.8516% (minimum 98%, Approved); choroid plexus: 46.7351% (minimum 99%, Missing); hippocampal formation: 92.6063% (minimum 99%, Missing); hypothalamus: 93.8202% (minimum 99%, Missing); lung: 94.1729% (minimum 98%, Approved); retina: 97.6608% (minimum 99%, Missing); skeletal muscle: 85.3492% (minimum 98%, Approved)",0.0420792,0.0201186,-0.522649,0,10,partial,57.1,0.8,0.6,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 2); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123977,DAW1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.7351% (minimum 75%, Missing)",0.342079,0.290119,-0.282649,0,10,partial,57.1,0.8,0.6,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 2); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123977,DAW1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.7351% (minimum 75%, Missing)",0.342079,0.290119,-0.282649,0,10,partial,57.1,0.8,0.6,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 2); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123977,DAW1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.7351% (minimum 75%, Missing)",0.342079,0.290119,-0.282649,0,10,partial,57.1,0.8,0.6,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 2); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123977,DAW1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.7351% (minimum 75%, Baseline (adaptation disabled))",0.338166,0.284283,-0.282649,0,10,partial,57.1,0.8,0.6,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123977,DAW1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.0034% (minimum 99%, Missing); amygdala: 95.9203% (minimum 99%, Missing); basal ganglia: 90.6726% (minimum 99%, Missing); cerebellum: 93.4381% (minimum 95%, Enhanced); choroid plexus: 98.0601% (minimum 99%, Missing); heart muscle: 86.4842% (minimum 95%, Enhanced); hippocampal formation: 95.8294% (minimum 99%, Missing); hypothalamus: 95.6481% (minimum 99%, Missing); midbrain: 98.0601% (minimum 99%, Missing); pancreas: 89.4690% (minimum 95%, Enhanced); pituitary gland: 94.0465% (minimum 99%, Missing); retina: 98.2507% (minimum 99%, Missing); spinal cord: 98.9237% (minimum 99%, Missing)",0.05,0.03,-0.409966,0,1,partial,73.2,1.5,3.2,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 6); pancreas: 11.9 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 6); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123999,INHA,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.0034% (minimum 75%, Missing)",0.35,0.3,-0.169966,0,1,partial,73.2,1.5,3.2,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 6); pancreas: 11.9 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 6); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123999,INHA,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.0034% (minimum 75%, Missing)",0.35,0.3,-0.169966,0,1,partial,73.2,1.5,3.2,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 6); pancreas: 11.9 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 6); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123999,INHA,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.0034% (minimum 75%, Missing)",0.35,0.3,-0.169966,0,1,partial,73.2,1.5,3.2,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 6); pancreas: 11.9 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 6); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123999,INHA,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.0034% (minimum 75%, Baseline (adaptation disabled))",0.319319,0.28538,-0.169966,0,1,partial,73.2,1.5,3.2,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 1); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000123999,INHA,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 6.6667% (minimum 99%, Missing)",0.05,0.03,-0.923333,0,2,partial,1.4,0,0,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124089,MC3R,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 6.6667% (minimum 75%, Missing)",0.35,0.3,-0.683333,0,2,partial,1.4,0,0,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124089,MC3R,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 6.6667% (minimum 75%, Missing)",0.35,0.3,-0.683333,0,2,partial,1.4,0,0,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124089,MC3R,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 6.6667% (minimum 75%, Missing)",0.35,0.3,-0.683333,0,2,partial,1.4,0,0,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124089,MC3R,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 6.6667% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.683333,0,2,partial,1.4,0,0,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124089,MC3R,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 92.3077% (minimum 95%, Enhanced); choroid plexus: 98.1818% (minimum 99%, Missing); retina: 92.3077% (minimum 99%, Missing)",0.0408257,0.0208257,-0.0669231,0,2,partial,0.9,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124092,CTCFL,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340826,0.290826,0.173077,0,2,partial,0.9,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124092,CTCFL,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340826,0.290826,0.173077,0,2,partial,0.9,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124092,CTCFL,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340826,0.290826,0.173077,0,2,partial,0.9,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124092,CTCFL,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.305752,0.264286,0.173077,0,2,partial,0.9,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124092,CTCFL,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 85.9932% (minimum 99%, Missing); small intestine: 98.9258% (minimum 99%, Missing)",0.028744,0.0154086,-0.130068,0,80,unavailable,16.5,1.5,2.2,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124103,FAM209A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328744,0.285409,0.109932,0,80,unavailable,16.5,1.5,2.2,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124103,FAM209A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328744,0.285409,0.109932,0,80,unavailable,16.5,1.5,2.2,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124103,FAM209A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328744,0.285409,0.109932,0,80,unavailable,16.5,1.5,2.2,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124103,FAM209A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328744,0.285409,0.109932,0,80,unavailable,16.5,1.5,2.2,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124103,FAM209A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.9796% (minimum 99%, Missing); choroid plexus: 94.6341% (minimum 99%, Missing); duodenum: 98.4772% (minimum 99%, Missing); hippocampal formation: 98.9796% (minimum 99%, Missing); hypothalamus: 98.9796% (minimum 99%, Missing); kidney: 98.9796% (minimum 99%, Missing); midbrain: 98.9796% (minimum 99%, Missing); retina: 98.4772% (minimum 99%, Missing); skin: 54.4944% (minimum 95%, Missing); smooth muscle: 95.5665% (minimum 99%, Missing)",-0.405056,0.0197959,-0.0436585,0,80,unavailable,1.1,0.2,16.2,"skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124116,WFDC3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 54.4944% (minimum 65%, Missing)",-0.105056,0.289796,0.196341,0,80,unavailable,1.1,0.2,16.2,"skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124116,WFDC3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 54.4944% (minimum 65%, Missing)",-0.105056,0.289796,0.196341,0,80,unavailable,1.1,0.2,16.2,"skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124116,WFDC3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 54.4944% (minimum 65%, Missing)",-0.105056,0.289796,0.196341,0,80,unavailable,1.1,0.2,16.2,"skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124116,WFDC3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 54.4944% (minimum 65%, Baseline (adaptation disabled))",-0.105056,0.289796,0.196341,0,80,unavailable,1.1,0.2,16.2,"skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124116,WFDC3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.0481643,0.03,0.01,0,1,partial,0.3,1.4,0.7,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124196,GTSF1L,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348164,0.3,0.25,0,1,partial,0.3,1.4,0.7,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124196,GTSF1L,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348164,0.3,0.25,0,1,partial,0.3,1.4,0.7,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124196,GTSF1L,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348164,0.3,0.25,0,1,partial,0.3,1.4,0.7,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124196,GTSF1L,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346792,0.293604,0.248623,0,1,partial,0.3,1.4,0.7,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124196,GTSF1L,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 95%, Missing); adrenal gland: 44.0000% (minimum 99%, Missing); amygdala: 75.1220% (minimum 99%, Missing); basal ganglia: 74.3961% (minimum 99%, Missing); bone marrow: 59.9222% (minimum 99%, Missing); cerebellum: 65.2542% (minimum 99%, Missing); cerebral cortex: 62.3482% (minimum 99%, Missing); choroid plexus: 78.9744% (minimum 99%, Missing); colon: 52.9210% (minimum 97%, Missing); duodenum: 53.6585% (minimum 99%, Missing); esophagus: 59.0038% (minimum 97%, Missing); heart muscle: 54.2254% (minimum 99%, Missing); hippocampal formation: 70.9677% (minimum 99%, Missing); hypothalamus: 71.2963% (minimum 99%, Missing); kidney: 50.9934% (minimum 99%, Missing); liver: 56.2044% (minimum 99%, Missing); lung: 66.9565% (minimum 99%, Missing); lymph node: 61.8474% (minimum 97%, Missing); midbrain: 70.3196% (minimum 99%, Missing); pancreas: 45.1613% (minimum 99%, Missing); parathyroid gland: 16.3482% (minimum 97%, Missing); pituitary gland: 64.4351% (minimum 99%, Missing); rectum: 50.3268% (minimum 97%, Missing); retina: 69.6833% (minimum 99%, Missing); salivary gland: 59.0038% (minimum 97%, Missing); skeletal muscle: 57.4627% (minimum 99%, Missing); skin: 58.7786% (minimum 95%, Missing); small intestine: 59.2308% (minimum 99%, Missing); smooth muscle: 62.8571% (minimum 99%, Missing); spinal cord: 68.1416% (minimum 99%, Missing); spleen: 60.3922% (minimum 95%, Missing); stomach: 49.3590% (minimum 97%, Missing); thymus: 58.3333% (minimum 95%, Missing); thyroid gland: 40.0000% (minimum 95%, Missing); tongue: 46.8085% (minimum 97%, Missing); urinary bladder: 58.7786% (minimum 97%, Missing)",-0.55,-0.806518,-0.55,0,4,partial,19.6,78.8,23.1,"parathyroid gland: 78.8 nTPM (protected, limit 2); thyroid gland: 23.1 nTPM (manageable, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 2); stomach: 15.8 nTPM (protected, limit 2); rectum: 15.2 nTPM (protected, limit 2); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 2); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); thymus: 11 nTPM (manageable, limit 5); skin: 10.8 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 2); salivary gland: 10.7 nTPM (protected, limit 2); esophagus: 10.7 nTPM (protected, limit 2); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); spleen: 10.1 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 2); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124198,ARFGEF2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 44.0000% (minimum 75%, Missing); basal ganglia: 74.3961% (minimum 75%, Missing); bone marrow: 59.9222% (minimum 75%, Missing); cerebellum: 65.2542% (minimum 75%, Missing); cerebral cortex: 62.3482% (minimum 75%, Missing); colon: 52.9210% (minimum 70%, Missing); duodenum: 53.6585% (minimum 75%, Missing); esophagus: 59.0038% (minimum 70%, Missing); heart muscle: 54.2254% (minimum 75%, Missing); hippocampal formation: 70.9677% (minimum 75%, Missing); hypothalamus: 71.2963% (minimum 75%, Missing); kidney: 50.9934% (minimum 75%, Missing); liver: 56.2044% (minimum 75%, Missing); lung: 66.9565% (minimum 75%, Missing); lymph node: 61.8474% (minimum 70%, Missing); midbrain: 70.3196% (minimum 75%, Missing); pancreas: 45.1613% (minimum 75%, Missing); parathyroid gland: 16.3482% (minimum 70%, Missing); pituitary gland: 64.4351% (minimum 75%, Missing); rectum: 50.3268% (minimum 70%, Missing); retina: 69.6833% (minimum 75%, Missing); salivary gland: 59.0038% (minimum 70%, Missing); skeletal muscle: 57.4627% (minimum 75%, Missing); skin: 58.7786% (minimum 65%, Missing); small intestine: 59.2308% (minimum 75%, Missing); smooth muscle: 62.8571% (minimum 75%, Missing); spinal cord: 68.1416% (minimum 75%, Missing); spleen: 60.3922% (minimum 65%, Missing); stomach: 49.3590% (minimum 70%, Missing); thymus: 58.3333% (minimum 65%, Missing); thyroid gland: 40.0000% (minimum 65%, Missing); tongue: 46.8085% (minimum 70%, Missing); urinary bladder: 58.7786% (minimum 70%, Missing)",-0.25,-0.536518,-0.31,0,4,partial,19.6,78.8,23.1,"parathyroid gland: 78.8 nTPM (protected, limit 2); thyroid gland: 23.1 nTPM (manageable, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 2); stomach: 15.8 nTPM (protected, limit 2); rectum: 15.2 nTPM (protected, limit 2); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 2); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); thymus: 11 nTPM (manageable, limit 5); skin: 10.8 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 2); salivary gland: 10.7 nTPM (protected, limit 2); esophagus: 10.7 nTPM (protected, limit 2); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); spleen: 10.1 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 2); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124198,ARFGEF2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 44.0000% (minimum 75%, Missing); basal ganglia: 74.3961% (minimum 75%, Missing); bone marrow: 59.9222% (minimum 75%, Missing); cerebellum: 65.2542% (minimum 75%, Missing); cerebral cortex: 62.3482% (minimum 75%, Missing); colon: 52.9210% (minimum 70%, Missing); duodenum: 53.6585% (minimum 75%, Missing); esophagus: 59.0038% (minimum 70%, Missing); heart muscle: 54.2254% (minimum 75%, Missing); hippocampal formation: 70.9677% (minimum 75%, Missing); hypothalamus: 71.2963% (minimum 75%, Missing); kidney: 50.9934% (minimum 75%, Missing); liver: 56.2044% (minimum 75%, Missing); lung: 66.9565% (minimum 75%, Missing); lymph node: 61.8474% (minimum 70%, Missing); midbrain: 70.3196% (minimum 75%, Missing); pancreas: 45.1613% (minimum 75%, Missing); parathyroid gland: 16.3482% (minimum 70%, Missing); pituitary gland: 64.4351% (minimum 75%, Missing); rectum: 50.3268% (minimum 70%, Missing); retina: 69.6833% (minimum 75%, Missing); salivary gland: 59.0038% (minimum 70%, Missing); skeletal muscle: 57.4627% (minimum 75%, Missing); skin: 58.7786% (minimum 65%, Missing); small intestine: 59.2308% (minimum 75%, Missing); smooth muscle: 62.8571% (minimum 75%, Missing); spinal cord: 68.1416% (minimum 75%, Missing); spleen: 60.3922% (minimum 65%, Missing); stomach: 49.3590% (minimum 70%, Missing); thymus: 58.3333% (minimum 65%, Missing); thyroid gland: 40.0000% (minimum 65%, Missing); tongue: 46.8085% (minimum 70%, Missing); urinary bladder: 58.7786% (minimum 70%, Missing)",-0.25,-0.536518,-0.31,0,4,partial,19.6,78.8,23.1,"parathyroid gland: 78.8 nTPM (protected, limit 3); thyroid gland: 23.1 nTPM (manageable, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 3); stomach: 15.8 nTPM (protected, limit 3); rectum: 15.2 nTPM (protected, limit 3); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 3); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); thymus: 11 nTPM (manageable, limit 5); skin: 10.8 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 3); salivary gland: 10.7 nTPM (protected, limit 3); esophagus: 10.7 nTPM (protected, limit 3); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); spleen: 10.1 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 3); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124198,ARFGEF2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 44.0000% (minimum 75%, Missing); basal ganglia: 74.3961% (minimum 75%, Missing); bone marrow: 59.9222% (minimum 75%, Missing); cerebellum: 65.2542% (minimum 75%, Missing); cerebral cortex: 62.3482% (minimum 75%, Missing); colon: 52.9210% (minimum 70%, Missing); duodenum: 53.6585% (minimum 75%, Missing); esophagus: 59.0038% (minimum 70%, Missing); heart muscle: 54.2254% (minimum 75%, Missing); hippocampal formation: 70.9677% (minimum 75%, Missing); hypothalamus: 71.2963% (minimum 75%, Missing); kidney: 50.9934% (minimum 75%, Missing); liver: 56.2044% (minimum 75%, Missing); lung: 66.9565% (minimum 75%, Missing); lymph node: 61.8474% (minimum 70%, Missing); midbrain: 70.3196% (minimum 75%, Missing); pancreas: 45.1613% (minimum 75%, Missing); parathyroid gland: 16.3482% (minimum 70%, Missing); pituitary gland: 64.4351% (minimum 75%, Missing); rectum: 50.3268% (minimum 70%, Missing); retina: 69.6833% (minimum 75%, Missing); salivary gland: 59.0038% (minimum 70%, Missing); skeletal muscle: 57.4627% (minimum 75%, Missing); skin: 58.7786% (minimum 65%, Missing); small intestine: 59.2308% (minimum 75%, Missing); smooth muscle: 62.8571% (minimum 75%, Missing); spinal cord: 68.1416% (minimum 75%, Missing); spleen: 60.3922% (minimum 65%, Missing); stomach: 49.3590% (minimum 70%, Missing); thymus: 58.3333% (minimum 65%, Missing); thyroid gland: 40.0000% (minimum 65%, Missing); tongue: 46.8085% (minimum 70%, Missing); urinary bladder: 58.7786% (minimum 70%, Missing)",-0.25,-0.536518,-0.31,0,4,partial,19.6,78.8,23.1,"parathyroid gland: 78.8 nTPM (protected, limit 3); thyroid gland: 23.1 nTPM (manageable, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 3); stomach: 15.8 nTPM (protected, limit 3); rectum: 15.2 nTPM (protected, limit 3); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 3); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); thymus: 11 nTPM (manageable, limit 5); skin: 10.8 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 3); salivary gland: 10.7 nTPM (protected, limit 3); esophagus: 10.7 nTPM (protected, limit 3); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); spleen: 10.1 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 3); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124198,ARFGEF2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 44.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.3961% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 59.9222% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.2542% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.3482% (minimum 75%, Baseline (adaptation disabled)); colon: 52.9210% (minimum 70%, Baseline (adaptation disabled)); duodenum: 53.6585% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.0038% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 54.2254% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.9677% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.2963% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.9934% (minimum 75%, Baseline (adaptation disabled)); liver: 56.2044% (minimum 75%, Baseline (adaptation disabled)); lung: 66.9565% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.8474% (minimum 70%, Baseline (adaptation disabled)); midbrain: 70.3196% (minimum 75%, Baseline (adaptation disabled)); pancreas: 45.1613% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 16.3482% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 64.4351% (minimum 75%, Baseline (adaptation disabled)); rectum: 50.3268% (minimum 70%, Baseline (adaptation disabled)); retina: 69.6833% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.0038% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 57.4627% (minimum 75%, Baseline (adaptation disabled)); skin: 58.7786% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.2308% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.8571% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.1416% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.3922% (minimum 65%, Baseline (adaptation disabled)); stomach: 49.3590% (minimum 70%, Baseline (adaptation disabled)); thymus: 58.3333% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 40.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 46.8085% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.7786% (minimum 70%, Baseline (adaptation disabled))",-0.25,-0.536518,-0.31,0,4,partial,19.6,78.8,23.1,"parathyroid gland: 78.8 nTPM (protected, limit 3); thyroid gland: 23.1 nTPM (manageable, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 3); stomach: 15.8 nTPM (protected, limit 3); rectum: 15.2 nTPM (protected, limit 3); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 3); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); thymus: 11 nTPM (manageable, limit 5); skin: 10.8 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 3); salivary gland: 10.7 nTPM (protected, limit 3); esophagus: 10.7 nTPM (protected, limit 3); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); spleen: 10.1 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 3); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124198,ARFGEF2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.2222% (minimum 99%, Missing); retina: 97.2222% (minimum 99%, Missing); skeletal muscle: 94.5946% (minimum 99%, Missing)",0.0222222,0.03,-0.0440541,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124227,ANKRD60,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.322222,0.3,0.195946,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124227,ANKRD60,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.322222,0.3,0.195946,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124227,ANKRD60,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.322222,0.3,0.195946,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124227,ANKRD60,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.322222,0.3,0.195946,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124227,ANKRD60,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 50.0000% (minimum 60%, Enhanced); duodenum: 66.6667% (minimum 95%, Enhanced); heart muscle: 66.6667% (minimum 95%, Enhanced); liver: 66.6667% (minimum 95%, Enhanced); pancreas: 0.0212% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 80%, Enhanced); stomach: 5.4054% (minimum 80%, Enhanced)",-0.1,-0.745946,-0.989788,0,0,routine_complete,944.9,3.5,0.2,"pancreas: 944.9 nTPM (vital, limit 1)",pancreas / pancreatic endocrine cells: Medium (Enhanced),55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124232,RBPJL,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 0.0212% (minimum 75%, Missing); stomach: 5.4054% (minimum 55%, Enhanced)",0,-0.495946,-0.749788,0,0,routine_complete,944.9,3.5,0.2,"pancreas: 944.9 nTPM (vital, limit 1)",pancreas / pancreatic endocrine cells: Medium (Enhanced),55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124232,RBPJL,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 0.0212% (minimum 75%, Missing); stomach: 5.4054% (minimum 55%, Enhanced)",0,-0.495946,-0.749788,0,0,routine_complete,944.9,3.5,0.2,"pancreas: 944.9 nTPM (vital, limit 1)",pancreas / pancreatic endocrine cells: Medium (Enhanced),55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124232,RBPJL,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 0.0212% (minimum 75%, Missing); stomach: 5.4054% (minimum 55%, Enhanced)",0,-0.495946,-0.749788,0,0,routine_complete,944.9,3.5,0.2,"pancreas: 944.9 nTPM (vital, limit 1)",pancreas / pancreatic endocrine cells: Medium (Enhanced),55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124232,RBPJL,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 0.0212% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); stomach: 5.4054% (minimum 70%, Baseline (adaptation disabled))",-0.15,-0.645946,-0.749788,0,0,routine_complete,944.9,3.5,0.2,"pancreas: 944.9 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3)",pancreas / pancreatic endocrine cells: Medium (Enhanced),55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124232,RBPJL,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 98.7879% (minimum 99%, Missing); lung: 94.6859% (minimum 95%, Enhanced)",0.0490919,0.03,-0.00314114,0,4,partial,24.7,0.1,0.4,"lung: 24.7 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000124237,CIMIP1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.349092,0.3,0.237879,0,4,partial,24.7,0.1,0.4,"lung: 24.7 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000124237,CIMIP1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.349092,0.3,0.237879,0,4,partial,24.7,0.1,0.4,"lung: 24.7 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000124237,CIMIP1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.349092,0.3,0.237879,0,4,partial,24.7,0.1,0.4,"lung: 24.7 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000124237,CIMIP1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.349092,0.299773,0.196859,0,4,partial,24.7,0.1,0.4,"lung: 24.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000124237,CIMIP1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.8085% (minimum 98%, Approved); choroid plexus: 98.9130% (minimum 99%, Missing); retina: 98.9130% (minimum 99%, Missing)",0.05,0.0284946,-0.0119149,0,4,partial,0.3,0.2,0.4,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124260,MAGEA10,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734,"Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016"
True,compatible,,True,True,True,,0.35,0.3,0.23913,0,4,partial,0.3,0.2,0.4,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124260,MAGEA10,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734,"Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016"
True,compatible,,True,True,True,,0.35,0.3,0.23913,0,4,partial,0.3,0.2,0.4,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124260,MAGEA10,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734,"Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016"
True,compatible,,True,True,True,,0.35,0.3,0.23913,0,4,partial,0.3,0.2,0.4,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124260,MAGEA10,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734,"Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016"
True,compatible,,True,True,True,,0.307895,0.278495,0.218085,0,4,partial,0.3,0.2,0.4,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124260,MAGEA10,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734,"Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016"
True,compatible,,True,True,True,,0.05,0.03,0.00931319,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124449,IRGC,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249313,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124449,IRGC,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249313,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124449,IRGC,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249313,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124449,IRGC,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249313,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124449,IRGC,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0.2,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124467,PSG8,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0.2,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124467,PSG8,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0.2,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124467,PSG8,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0.2,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124467,PSG8,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.269231,0.25,0,3,partial,0,0.2,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124467,PSG8,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.05,0.03,0.00171717,0,1,partial,16.5,15.1,0.5,"bone marrow: 16.5 nTPM (vital, limit 6); salivary gland: 15.1 nTPM (protected, limit 12); choroid plexus: 4.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124490,CRISP2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.241717,0,1,partial,16.5,15.1,0.5,"bone marrow: 16.5 nTPM (vital, limit 6); salivary gland: 15.1 nTPM (protected, limit 12); choroid plexus: 4.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124490,CRISP2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.241717,0,1,partial,16.5,15.1,0.5,"bone marrow: 16.5 nTPM (vital, limit 6); salivary gland: 15.1 nTPM (protected, limit 12); choroid plexus: 4.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124490,CRISP2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.241717,0,1,partial,16.5,15.1,0.5,"bone marrow: 16.5 nTPM (vital, limit 6); salivary gland: 15.1 nTPM (protected, limit 12); choroid plexus: 4.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124490,CRISP2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348982,0.270158,0.217481,0,1,partial,16.5,15.1,0.5,"bone marrow: 16.5 nTPM (vital, limit 1); salivary gland: 15.1 nTPM (protected, limit 3); choroid plexus: 4.1 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124490,CRISP2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;family_exclusion,True,True,True,"thyroid gland: 50.0000% (minimum 60%, Enhanced)",-0.1,0.03,0.01,0,5,partial,0,0,0.1,,esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124610,H1-1,admission_only,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0,0.3,0.25,0,5,partial,0,0,0.1,,esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124610,H1-1,selectivity_revised,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0,0.3,0.25,0,5,partial,0,0,0.1,,esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124610,H1-1,grid_revised,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0,0.3,0.25,0,5,partial,0,0,0.1,,esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124610,H1-1,current_adaptive,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;family_exclusion,True,True,True,"thyroid gland: 50.0000% (minimum 65%, Baseline (adaptation disabled))",-0.15,0.3,0.25,0,5,partial,0,0,0.1,,esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124610,H1-1,current_fixed,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.3333% (minimum 95%, Missing); adrenal gland: 72.2222% (minimum 99%, Missing); amygdala: 72.2222% (minimum 99%, Missing); basal ganglia: 63.4146% (minimum 99%, Missing); bone marrow: 94.5455% (minimum 99%, Missing); cerebellum: 65.8228% (minimum 99%, Missing); cerebral cortex: 62.6506% (minimum 99%, Missing); choroid plexus: 82.5397% (minimum 99%, Missing); colon: 76.4706% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); esophagus: 75.3623% (minimum 97%, Missing); heart muscle: 83.8710% (minimum 99%, Missing); hippocampal formation: 70.2703% (minimum 99%, Missing); hypothalamus: 72.2222% (minimum 99%, Missing); kidney: 65.8228% (minimum 99%, Missing); liver: 94.5455% (minimum 99%, Missing); lung: 74.2857% (minimum 99%, Missing); lymph node: 74.2857% (minimum 97%, Missing); midbrain: 78.7879% (minimum 99%, Missing); pancreas: 71.2329% (minimum 99%, Missing); parathyroid gland: 59.0909% (minimum 97%, Missing); pituitary gland: 75.3623% (minimum 99%, Missing); rectum: 76.4706% (minimum 97%, Missing); retina: 72.2222% (minimum 99%, Missing); salivary gland: 71.2329% (minimum 97%, Missing); skeletal muscle: 91.2281% (minimum 99%, Missing); skin: 75.3623% (minimum 95%, Missing); small intestine: 83.8710% (minimum 99%, Missing); smooth muscle: 69.3333% (minimum 99%, Missing); spinal cord: 77.6119% (minimum 99%, Missing); spleen: 70.2703% (minimum 95%, Missing); stomach: 77.6119% (minimum 97%, Missing); thymus: 80.0000% (minimum 95%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); tongue: 86.6667% (minimum 97%, Missing); urinary bladder: 76.4706% (minimum 97%, Missing)",-0.378571,-0.379091,-0.363494,0,80,unavailable,3.1,3.6,3.9,"parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124613,ZNF391,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 63.4146% (minimum 75%, Missing); cerebellum: 65.8228% (minimum 75%, Missing); cerebral cortex: 62.6506% (minimum 75%, Missing); hippocampal formation: 70.2703% (minimum 75%, Missing); hypothalamus: 72.2222% (minimum 75%, Missing); kidney: 65.8228% (minimum 75%, Missing); lung: 74.2857% (minimum 75%, Missing); pancreas: 71.2329% (minimum 75%, Missing); parathyroid gland: 59.0909% (minimum 70%, Missing); retina: 72.2222% (minimum 75%, Missing); smooth muscle: 69.3333% (minimum 75%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.109091,-0.123494,0,80,unavailable,3.1,3.6,3.9,"parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124613,ZNF391,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 63.4146% (minimum 75%, Missing); cerebellum: 65.8228% (minimum 75%, Missing); cerebral cortex: 62.6506% (minimum 75%, Missing); hippocampal formation: 70.2703% (minimum 75%, Missing); hypothalamus: 72.2222% (minimum 75%, Missing); kidney: 65.8228% (minimum 75%, Missing); lung: 74.2857% (minimum 75%, Missing); pancreas: 71.2329% (minimum 75%, Missing); parathyroid gland: 59.0909% (minimum 70%, Missing); retina: 72.2222% (minimum 75%, Missing); smooth muscle: 69.3333% (minimum 75%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.109091,-0.123494,0,80,unavailable,3.1,3.6,3.9,"parathyroid gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124613,ZNF391,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 63.4146% (minimum 75%, Missing); cerebellum: 65.8228% (minimum 75%, Missing); cerebral cortex: 62.6506% (minimum 75%, Missing); hippocampal formation: 70.2703% (minimum 75%, Missing); hypothalamus: 72.2222% (minimum 75%, Missing); kidney: 65.8228% (minimum 75%, Missing); lung: 74.2857% (minimum 75%, Missing); pancreas: 71.2329% (minimum 75%, Missing); parathyroid gland: 59.0909% (minimum 70%, Missing); retina: 72.2222% (minimum 75%, Missing); smooth muscle: 69.3333% (minimum 75%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.109091,-0.123494,0,80,unavailable,3.1,3.6,3.9,"parathyroid gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124613,ZNF391,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.2222% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 63.4146% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.8228% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.6506% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.2703% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.2222% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.8228% (minimum 75%, Baseline (adaptation disabled)); lung: 74.2857% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.2329% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.0909% (minimum 70%, Baseline (adaptation disabled)); retina: 72.2222% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 69.3333% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 65%, Baseline (adaptation disabled))",-0.0785714,-0.109091,-0.123494,0,80,unavailable,3.1,3.6,3.9,"parathyroid gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124613,ZNF391,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0496982,0.0290953,0.0090953,0,2,partial,0.5,0.4,0.4,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124678,TCP11,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349698,0.299095,0.249095,0,2,partial,0.5,0.4,0.4,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124678,TCP11,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349698,0.299095,0.249095,0,2,partial,0.5,0.4,0.4,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124678,TCP11,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349698,0.299095,0.249095,0,2,partial,0.5,0.4,0.4,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124678,TCP11,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348794,0.298794,0.248493,0,2,partial,0.5,0.4,0.4,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124678,TCP11,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 98.7013% (minimum 99%, Missing); lymph node: 93.8272% (minimum 97%, Missing); skin: 82.6087% (minimum 95%, Missing); small intestine: 98.7013% (minimum 99%, Missing); spleen: 90.4762% (minimum 95%, Missing)",-0.123913,-0.0317284,-0.00298701,0,80,unavailable,0.1,0.5,1.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124721,DNAH8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.176087,0.238272,0.237013,0,80,unavailable,0.1,0.5,1.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124721,DNAH8,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.176087,0.238272,0.237013,0,80,unavailable,0.1,0.5,1.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124721,DNAH8,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.176087,0.238272,0.237013,0,80,unavailable,0.1,0.5,1.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124721,DNAH8,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.176087,0.238272,0.237013,0,80,unavailable,0.1,0.5,1.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124721,DNAH8,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0.3,0,,,49,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124812,CRISP1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0.3,0,,,49,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124812,CRISP1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0.3,0,,,49,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124812,CRISP1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0.3,0,,,49,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124812,CRISP1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299805,0.25,0,5,partial,0,0.3,0,,,49,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124812,CRISP1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"heart muscle: 86.2069% (minimum 97%, Supported); skeletal muscle: 96.1538% (minimum 97%, Supported); tongue: 96.1538% (minimum 97%, Missing)",0.05,-0.00846154,-0.107931,0,1,partial,0.4,0.1,0,,retina / photoreceptor cells: High (Supported),63,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124818,OPN5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.261538,0.212069,0,1,partial,0.4,0.1,0,,retina / photoreceptor cells: High (Supported),63,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124818,OPN5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.261538,0.212069,0,1,partial,0.4,0.1,0,,retina / photoreceptor cells: High (Supported),63,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124818,OPN5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.261538,0.212069,0,1,partial,0.4,0.1,0,,retina / photoreceptor cells: High (Supported),63,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124818,OPN5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.261538,0.112069,0,1,partial,0.4,0.1,0,,retina / photoreceptor cells: High (Supported),63,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124818,OPN5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124900,TRIM51,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124900,TRIM51,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124900,TRIM51,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124900,TRIM51,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000124900,TRIM51,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 98.3412% (minimum 99%, Missing); retina: 97.4178% (minimum 99%, Missing)",0.05,0.03,-0.0158216,0,3,partial,1.1,0,0.4,"retina: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125207,PIWIL1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224178,0,3,partial,1.1,0,0.4,"retina: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125207,PIWIL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224178,0,3,partial,1.1,0,0.4,"retina: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125207,PIWIL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224178,0,3,partial,1.1,0,0.4,"retina: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125207,PIWIL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340453,0.3,0.224178,0,3,partial,1.1,0,0.4,"retina: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125207,PIWIL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.9507% (minimum 95%, Enhanced); duodenum: 92.7007% (minimum 95%, Enhanced); liver: 93.3824% (minimum 95%, Enhanced); lung: 94.7761% (minimum 95%, Enhanced); lymph node: 25.0493% (minimum 97%, Missing); small intestine: 76.5060% (minimum 95%, Enhanced); spinal cord: 98.4496% (minimum 99%, Missing); spleen: 55.4585% (minimum 95%, Missing); thymus: 62.2549% (minimum 95%, Missing)",-0.395415,-0.719507,-0.380493,0,0,routine_complete,9.6,38,10.2,"lymph node: 38 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 6); thymus: 7.7 nTPM (manageable, limit 5)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125245,GPR18,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.9507% (minimum 60%, Enhanced); lymph node: 25.0493% (minimum 70%, Missing); spleen: 55.4585% (minimum 65%, Missing); thymus: 62.2549% (minimum 65%, Missing)",-0.0954148,-0.449507,-0.0304933,0,0,routine_complete,9.6,38,10.2,"lymph node: 38 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 6); thymus: 7.7 nTPM (manageable, limit 5)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125245,GPR18,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.9507% (minimum 60%, Enhanced); lymph node: 25.0493% (minimum 70%, Missing); spleen: 55.4585% (minimum 65%, Missing); thymus: 62.2549% (minimum 65%, Missing)",-0.0954148,-0.449507,-0.0304933,0,0,routine_complete,9.6,38,10.2,"lymph node: 38 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 6); thymus: 7.7 nTPM (manageable, limit 5)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125245,GPR18,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.9507% (minimum 60%, Enhanced); lymph node: 25.0493% (minimum 70%, Missing); spleen: 55.4585% (minimum 65%, Missing); thymus: 62.2549% (minimum 65%, Missing)",-0.0954148,-0.449507,-0.0304933,0,0,routine_complete,9.6,38,10.2,"lymph node: 38 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 6); thymus: 7.7 nTPM (manageable, limit 5)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125245,GPR18,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.9507% (minimum 75%, Baseline (adaptation disabled)); lymph node: 25.0493% (minimum 70%, Baseline (adaptation disabled)); spleen: 55.4585% (minimum 65%, Baseline (adaptation disabled)); thymus: 62.2549% (minimum 65%, Baseline (adaptation disabled))",-0.0954148,-0.449507,-0.180493,0,0,routine_complete,9.6,38,10.2,"lymph node: 38 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125245,GPR18,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.8000% (minimum 95%, Missing); adrenal gland: 96.5217% (minimum 99%, Missing); amygdala: 98.2301% (minimum 99%, Missing); basal ganglia: 98.2301% (minimum 99%, Missing); bone marrow: 54.6798% (minimum 99%, Missing); cerebellum: 94.0678% (minimum 99%, Missing); cerebral cortex: 97.3684% (minimum 99%, Missing); choroid plexus: 98.2301% (minimum 99%, Missing); colon: 92.5000% (minimum 97%, Missing); duodenum: 93.2773% (minimum 99%, Missing); esophagus: 80.4348% (minimum 97%, Missing); heart muscle: 94.0678% (minimum 99%, Missing); hippocampal formation: 98.2301% (minimum 99%, Missing); hypothalamus: 96.5217% (minimum 99%, Missing); kidney: 96.5217% (minimum 99%, Missing); liver: 94.8718% (minimum 99%, Missing); lung: 94.8718% (minimum 99%, Missing); lymph node: 87.4016% (minimum 97%, Missing); midbrain: 97.3684% (minimum 99%, Missing); pancreas: 97.3684% (minimum 99%, Missing); parathyroid gland: 96.5217% (minimum 97%, Missing); pituitary gland: 96.5217% (minimum 99%, Missing); rectum: 91.7355% (minimum 97%, Missing); retina: 97.3684% (minimum 99%, Missing); salivary gland: 94.0678% (minimum 97%, Missing); skeletal muscle: 92.5000% (minimum 99%, Missing); skin: 86.7188% (minimum 95%, Missing); small intestine: 92.5000% (minimum 99%, Missing); smooth muscle: 94.8718% (minimum 99%, Uncertain); spinal cord: 98.2301% (minimum 99%, Missing); spleen: 90.2439% (minimum 95%, Missing); stomach: 94.8718% (minimum 97%, Missing); thymus: 83.4586% (minimum 95%, Missing); urinary bladder: 94.8718% (minimum 97%, Missing)",-0.115414,-0.165652,-0.443202,0,0,routine_complete,9.2,2.7,2.2,"bone marrow: 9.2 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125319,HROB,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.6798% (minimum 75%, Missing)",0.184586,0.104348,-0.203202,0,0,routine_complete,9.2,2.7,2.2,"bone marrow: 9.2 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125319,HROB,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.6798% (minimum 75%, Missing)",0.184586,0.104348,-0.203202,0,0,routine_complete,9.2,2.7,2.2,"bone marrow: 9.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125319,HROB,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.6798% (minimum 75%, Missing)",0.184586,0.104348,-0.203202,0,0,routine_complete,9.2,2.7,2.2,"bone marrow: 9.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125319,HROB,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.6798% (minimum 75%, Baseline (adaptation disabled))",0.184586,0.104348,-0.203202,0,0,routine_complete,9.2,2.7,2.2,"bone marrow: 9.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125319,HROB,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.7765% (minimum 98%, Approved); amygdala: 88.1974% (minimum 99%, Missing); basal ganglia: 89.7380% (minimum 99%, Missing); bone marrow: 96.9340% (minimum 98%, Approved); cerebellum: 77.2556% (minimum 98%, Approved); cerebral cortex: 87.4468% (minimum 99%, Missing); choroid plexus: 93.8356% (minimum 99%, Missing); colon: 93.8356% (minimum 97%, Missing); duodenum: 97.6247% (minimum 98%, Approved); heart muscle: 89.7380% (minimum 98%, Approved); hippocampal formation: 87.6333% (minimum 99%, Missing); hypothalamus: 88.5776% (minimum 99%, Missing); kidney: 95.1389% (minimum 98%, Approved); liver: 95.5814% (minimum 98%, Approved); lung: 95.3596% (minimum 98%, Approved); midbrain: 87.8205% (minimum 99%, Missing); pancreas: 88.7689% (minimum 98%, Approved); parathyroid gland: 90.7285% (minimum 95%, Approved); pituitary gland: 87.2611% (minimum 99%, Missing); retina: 80.7466% (minimum 99%, Missing); salivary gland: 93.6219% (minimum 95%, Approved); skeletal muscle: 89.9344% (minimum 98%, Approved); small intestine: 96.7059% (minimum 98%, Approved); smooth muscle: 95.3596% (minimum 98%, Approved); spinal cord: 86.3445% (minimum 99%, Missing); stomach: 93.4091% (minimum 95%, Approved); tongue: 90.7285% (minimum 97%, Missing); urinary bladder: 94.9192% (minimum 95%, Approved)",0.0125293,-0.0627152,-0.207444,0,7,partial,12.1,4.2,3.2,"cerebellum: 12.1 nTPM (vital, limit 2); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2); tongue: 4.2 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 4); adrenal gland: 3.2 nTPM (vital, limit 2); colon: 2.7 nTPM (protected, limit 2); choroid plexus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125388,GRK4,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.312529,0.207285,0.0574656,0,7,partial,12.1,4.2,3.2,"cerebellum: 12.1 nTPM (vital, limit 2); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2); tongue: 4.2 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 4); adrenal gland: 3.2 nTPM (vital, limit 2); colon: 2.7 nTPM (protected, limit 2); choroid plexus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125388,GRK4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.312529,0.207285,0.0574656,0,7,partial,12.1,4.2,3.2,"cerebellum: 12.1 nTPM (vital, limit 2); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2); tongue: 4.2 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 4); adrenal gland: 3.2 nTPM (vital, limit 2); choroid plexus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125388,GRK4,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.312529,0.207285,0.0574656,0,7,partial,12.1,4.2,3.2,"cerebellum: 12.1 nTPM (vital, limit 2); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2); tongue: 4.2 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 4); adrenal gland: 3.2 nTPM (vital, limit 2); choroid plexus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125388,GRK4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277765,0.207285,0.0225564,0,7,partial,12.1,4.2,3.2,"cerebellum: 12.1 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 3); adrenal gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125388,GRK4,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.4194% (minimum 99%, Missing); basal ganglia: 96.4856% (minimum 99%, Missing); cerebellum: 92.3547% (minimum 95%, Enhanced); choroid plexus: 95.5696% (minimum 99%, Missing); hippocampal formation: 97.1061% (minimum 99%, Missing); hypothalamus: 96.7949% (minimum 99%, Missing); lung: 97.4194% (minimum 99%, Missing); midbrain: 98.6928% (minimum 99%, Missing); pituitary gland: 97.1061% (minimum 99%, Missing); retina: 98.0519% (minimum 99%, Missing); spinal cord: 98.3713% (minimum 99%, Missing)",0.0466997,0.0266997,-0.0343038,0,5,partial,2.5,0.4,0.7,"choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125409,TEKT3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.3467,0.2967,0.205696,0,5,partial,2.5,0.4,0.7,"choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125409,TEKT3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.3467,0.2967,0.205696,0,5,partial,2.5,0.4,0.7,"choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125409,TEKT3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.3467,0.2967,0.205696,0,5,partial,2.5,0.4,0.7,"choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125409,TEKT3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327346,0.286928,0.173547,0,5,partial,2.5,0.4,0.7,"cerebellum: 2.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125409,TEKT3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 98.8701% (minimum 99%, Missing)",0.040566,0.0233775,-0.00129944,0,80,unavailable,1.2,0.7,1,"kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125531,FNDC11,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340566,0.293377,0.238701,0,80,unavailable,1.2,0.7,1,"kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125531,FNDC11,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340566,0.293377,0.238701,0,80,unavailable,1.2,0.7,1,"kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125531,FNDC11,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340566,0.293377,0.238701,0,80,unavailable,1.2,0.7,1,"kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125531,FNDC11,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340566,0.293377,0.238701,0,80,unavailable,1.2,0.7,1,"kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125531,FNDC11,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 99%, Missing); thymus: 50.0000% (minimum 95%, Missing)",-0.45,0.03,-0.323333,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125533,BHLHE23,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.0833333,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125533,BHLHE23,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.0833333,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125533,BHLHE23,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.0833333,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125533,BHLHE23,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 75%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 65%, Baseline (adaptation disabled))",-0.15,0.3,-0.0833333,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125533,BHLHE23,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8282% (minimum 90%, Approved); adrenal gland: 47.9554% (minimum 99%, Missing); amygdala: 64.1791% (minimum 99%, Missing); basal ganglia: 59.7222% (minimum 99%, Missing); bone marrow: 37.5000% (minimum 98%, Approved); cerebellum: 45.1049% (minimum 99%, Missing); cerebral cortex: 59.1743% (minimum 99%, Missing); choroid plexus: 46.4029% (minimum 99%, Missing); colon: 54.2017% (minimum 97%, Missing); duodenum: 52.6531% (minimum 99%, Missing); esophagus: 64.1791% (minimum 97%, Missing); heart muscle: 38.5075% (minimum 99%, Missing); hippocampal formation: 65.1515% (minimum 99%, Missing); hypothalamus: 61.4286% (minimum 99%, Missing); kidney: 57.5893% (minimum 99%, Missing); liver: 62.9268% (minimum 99%, Missing); lung: 53.0864% (minimum 99%, Missing); lymph node: 56.0870% (minimum 97%, Missing); midbrain: 63.5468% (minimum 99%, Missing); pancreas: 50.3906% (minimum 99%, Missing); parathyroid gland: 45.5830% (minimum 97%, Missing); pituitary gland: 45.2632% (minimum 99%, Missing); rectum: 55.6034% (minimum 97%, Missing); retina: 33.8583% (minimum 99%, Missing); salivary gland: 59.4470% (minimum 97%, Missing); skeletal muscle: 50.9881% (minimum 99%, Missing); skin: 54.6610% (minimum 95%, Missing); small intestine: 50.9881% (minimum 99%, Missing); smooth muscle: 62.3188% (minimum 99%, Missing); spinal cord: 64.1791% (minimum 99%, Missing); spleen: 52.2267% (minimum 90%, Approved); stomach: 59.4470% (minimum 97%, Missing); thymus: 56.8282% (minimum 95%, Missing); thyroid gland: 52.8689% (minimum 95%, Missing); tongue: 56.5789% (minimum 97%, Missing); urinary bladder: 60.8491% (minimum 97%, Missing)",-0.421311,-0.51417,-0.651417,0,5,partial,25.2,15.4,11.8,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 2); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 10); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 2); skin: 10.7 nTPM (manageable, limit 5); rectum: 10.3 nTPM (protected, limit 2); lymph node: 10.1 nTPM (protected, limit 2); tongue: 9.9 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 2); salivary gland: 8.8 nTPM (protected, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 2); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); hippocampal formation: 6.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125633,CCDC93,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8282% (minimum 60%, Approved); adrenal gland: 47.9554% (minimum 75%, Missing); amygdala: 64.1791% (minimum 75%, Missing); basal ganglia: 59.7222% (minimum 75%, Missing); bone marrow: 37.5000% (minimum 70%, Approved); cerebellum: 45.1049% (minimum 75%, Missing); cerebral cortex: 59.1743% (minimum 75%, Missing); choroid plexus: 46.4029% (minimum 75%, Missing); colon: 54.2017% (minimum 70%, Missing); duodenum: 52.6531% (minimum 75%, Missing); esophagus: 64.1791% (minimum 70%, Missing); heart muscle: 38.5075% (minimum 75%, Missing); hippocampal formation: 65.1515% (minimum 75%, Missing); hypothalamus: 61.4286% (minimum 75%, Missing); kidney: 57.5893% (minimum 75%, Missing); liver: 62.9268% (minimum 75%, Missing); lung: 53.0864% (minimum 75%, Missing); lymph node: 56.0870% (minimum 70%, Missing); midbrain: 63.5468% (minimum 75%, Missing); pancreas: 50.3906% (minimum 75%, Missing); parathyroid gland: 45.5830% (minimum 70%, Missing); pituitary gland: 45.2632% (minimum 75%, Missing); rectum: 55.6034% (minimum 70%, Missing); retina: 33.8583% (minimum 75%, Missing); salivary gland: 59.4470% (minimum 70%, Missing); skeletal muscle: 50.9881% (minimum 75%, Missing); skin: 54.6610% (minimum 65%, Missing); small intestine: 50.9881% (minimum 75%, Missing); smooth muscle: 62.3188% (minimum 75%, Missing); spinal cord: 64.1791% (minimum 75%, Missing); spleen: 52.2267% (minimum 60%, Approved); stomach: 59.4470% (minimum 70%, Missing); thymus: 56.8282% (minimum 65%, Missing); thyroid gland: 52.8689% (minimum 65%, Missing); tongue: 56.5789% (minimum 70%, Missing); urinary bladder: 60.8491% (minimum 70%, Missing)",-0.121311,-0.24417,-0.411417,0,5,partial,25.2,15.4,11.8,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 2); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 10); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 2); skin: 10.7 nTPM (manageable, limit 5); rectum: 10.3 nTPM (protected, limit 2); lymph node: 10.1 nTPM (protected, limit 2); tongue: 9.9 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 2); salivary gland: 8.8 nTPM (protected, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 2); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); hippocampal formation: 6.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125633,CCDC93,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8282% (minimum 60%, Approved); adrenal gland: 47.9554% (minimum 75%, Missing); amygdala: 64.1791% (minimum 75%, Missing); basal ganglia: 59.7222% (minimum 75%, Missing); bone marrow: 37.5000% (minimum 70%, Approved); cerebellum: 45.1049% (minimum 75%, Missing); cerebral cortex: 59.1743% (minimum 75%, Missing); choroid plexus: 46.4029% (minimum 75%, Missing); colon: 54.2017% (minimum 70%, Missing); duodenum: 52.6531% (minimum 75%, Missing); esophagus: 64.1791% (minimum 70%, Missing); heart muscle: 38.5075% (minimum 75%, Missing); hippocampal formation: 65.1515% (minimum 75%, Missing); hypothalamus: 61.4286% (minimum 75%, Missing); kidney: 57.5893% (minimum 75%, Missing); liver: 62.9268% (minimum 75%, Missing); lung: 53.0864% (minimum 75%, Missing); lymph node: 56.0870% (minimum 70%, Missing); midbrain: 63.5468% (minimum 75%, Missing); pancreas: 50.3906% (minimum 75%, Missing); parathyroid gland: 45.5830% (minimum 70%, Missing); pituitary gland: 45.2632% (minimum 75%, Missing); rectum: 55.6034% (minimum 70%, Missing); retina: 33.8583% (minimum 75%, Missing); salivary gland: 59.4470% (minimum 70%, Missing); skeletal muscle: 50.9881% (minimum 75%, Missing); skin: 54.6610% (minimum 65%, Missing); small intestine: 50.9881% (minimum 75%, Missing); smooth muscle: 62.3188% (minimum 75%, Missing); spinal cord: 64.1791% (minimum 75%, Missing); spleen: 52.2267% (minimum 60%, Approved); stomach: 59.4470% (minimum 70%, Missing); thymus: 56.8282% (minimum 65%, Missing); thyroid gland: 52.8689% (minimum 65%, Missing); tongue: 56.5789% (minimum 70%, Missing); urinary bladder: 60.8491% (minimum 70%, Missing)",-0.121311,-0.24417,-0.411417,0,5,partial,25.2,15.4,11.8,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 3); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 10); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 3); skin: 10.7 nTPM (manageable, limit 5); rectum: 10.3 nTPM (protected, limit 3); lymph node: 10.1 nTPM (protected, limit 3); tongue: 9.9 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 3); salivary gland: 8.8 nTPM (protected, limit 3); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 3); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); hippocampal formation: 6.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125633,CCDC93,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8282% (minimum 60%, Approved); adrenal gland: 47.9554% (minimum 75%, Missing); amygdala: 64.1791% (minimum 75%, Missing); basal ganglia: 59.7222% (minimum 75%, Missing); bone marrow: 37.5000% (minimum 70%, Approved); cerebellum: 45.1049% (minimum 75%, Missing); cerebral cortex: 59.1743% (minimum 75%, Missing); choroid plexus: 46.4029% (minimum 75%, Missing); colon: 54.2017% (minimum 70%, Missing); duodenum: 52.6531% (minimum 75%, Missing); esophagus: 64.1791% (minimum 70%, Missing); heart muscle: 38.5075% (minimum 75%, Missing); hippocampal formation: 65.1515% (minimum 75%, Missing); hypothalamus: 61.4286% (minimum 75%, Missing); kidney: 57.5893% (minimum 75%, Missing); liver: 62.9268% (minimum 75%, Missing); lung: 53.0864% (minimum 75%, Missing); lymph node: 56.0870% (minimum 70%, Missing); midbrain: 63.5468% (minimum 75%, Missing); pancreas: 50.3906% (minimum 75%, Missing); parathyroid gland: 45.5830% (minimum 70%, Missing); pituitary gland: 45.2632% (minimum 75%, Missing); rectum: 55.6034% (minimum 70%, Missing); retina: 33.8583% (minimum 75%, Missing); salivary gland: 59.4470% (minimum 70%, Missing); skeletal muscle: 50.9881% (minimum 75%, Missing); skin: 54.6610% (minimum 65%, Missing); small intestine: 50.9881% (minimum 75%, Missing); smooth muscle: 62.3188% (minimum 75%, Missing); spinal cord: 64.1791% (minimum 75%, Missing); spleen: 52.2267% (minimum 60%, Approved); stomach: 59.4470% (minimum 70%, Missing); thymus: 56.8282% (minimum 65%, Missing); thyroid gland: 52.8689% (minimum 65%, Missing); tongue: 56.5789% (minimum 70%, Missing); urinary bladder: 60.8491% (minimum 70%, Missing)",-0.121311,-0.24417,-0.411417,0,5,partial,25.2,15.4,11.8,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 3); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 10); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 3); skin: 10.7 nTPM (manageable, limit 5); rectum: 10.3 nTPM (protected, limit 3); lymph node: 10.1 nTPM (protected, limit 3); tongue: 9.9 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 3); salivary gland: 8.8 nTPM (protected, limit 3); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 3); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); hippocampal formation: 6.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125633,CCDC93,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8282% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 47.9554% (minimum 75%, Baseline (adaptation disabled)); amygdala: 64.1791% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 59.7222% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 37.5000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 45.1049% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 59.1743% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 46.4029% (minimum 75%, Baseline (adaptation disabled)); colon: 54.2017% (minimum 70%, Baseline (adaptation disabled)); duodenum: 52.6531% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.1791% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 38.5075% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.1515% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.4286% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.5893% (minimum 75%, Baseline (adaptation disabled)); liver: 62.9268% (minimum 75%, Baseline (adaptation disabled)); lung: 53.0864% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.0870% (minimum 70%, Baseline (adaptation disabled)); midbrain: 63.5468% (minimum 75%, Baseline (adaptation disabled)); pancreas: 50.3906% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 45.5830% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 45.2632% (minimum 75%, Baseline (adaptation disabled)); rectum: 55.6034% (minimum 70%, Baseline (adaptation disabled)); retina: 33.8583% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.4470% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 50.9881% (minimum 75%, Baseline (adaptation disabled)); skin: 54.6610% (minimum 65%, Baseline (adaptation disabled)); small intestine: 50.9881% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.3188% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.1791% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.2267% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.4470% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.8282% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.8689% (minimum 65%, Baseline (adaptation disabled)); tongue: 56.5789% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.8491% (minimum 70%, Baseline (adaptation disabled))",-0.127733,-0.24417,-0.411417,0,5,partial,25.2,15.4,11.8,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 3); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 5); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 3); skin: 10.7 nTPM (manageable, limit 5); rectum: 10.3 nTPM (protected, limit 3); lymph node: 10.1 nTPM (protected, limit 3); tongue: 9.9 nTPM (protected, limit 3); adipose tissue: 9.8 nTPM (manageable, limit 5); thymus: 9.8 nTPM (manageable, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); salivary gland: 8.8 nTPM (protected, limit 3); stomach: 8.8 nTPM (protected, limit 3); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 3); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125633,CCDC93,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.00992008,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125788,DEFB126,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.24992,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125788,DEFB126,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.24992,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125788,DEFB126,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.24992,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125788,DEFB126,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.24992,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125788,DEFB126,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00541284,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125815,CST8,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245413,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125815,CST8,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245413,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125815,CST8,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245413,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125815,CST8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245413,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125815,CST8,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 68.7500% (minimum 99%, Missing); pituitary gland: 84.6154% (minimum 99%, Missing)",0.05,0.03,-0.3025,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125816,NKX2-4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 68.7500% (minimum 75%, Missing)",0.35,0.3,-0.0625,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125816,NKX2-4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 68.7500% (minimum 75%, Missing)",0.35,0.3,-0.0625,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125816,NKX2-4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 68.7500% (minimum 75%, Missing)",0.35,0.3,-0.0625,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125816,NKX2-4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 68.7500% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.0625,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125816,NKX2-4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 94.4444% (minimum 97%, Missing)",0.05,-0.0255556,0.01,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125823,CSTL1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.244444,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125823,CSTL1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.244444,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125823,CSTL1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.244444,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125823,CSTL1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.244444,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125823,CSTL1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 74.0000% (minimum 95%, Enhanced); amygdala: 62.7119% (minimum 99%, Missing); basal ganglia: 53.6232% (minimum 99%, Missing); bone marrow: 90.2439% (minimum 95%, Enhanced); cerebellum: 67.2727% (minimum 95%, Enhanced); cerebral cortex: 57.8125% (minimum 95%, Enhanced); choroid plexus: 56.0606% (minimum 99%, Missing); colon: 74.0000% (minimum 80%, Enhanced); duodenum: 92.5000% (minimum 95%, Enhanced); esophagus: 78.7234% (minimum 80%, Enhanced); heart muscle: 84.0909% (minimum 95%, Enhanced); hippocampal formation: 63.7931% (minimum 99%, Missing); hypothalamus: 61.6667% (minimum 99%, Missing); kidney: 50.6849% (minimum 95%, Enhanced); liver: 92.5000% (minimum 95%, Enhanced); lung: 69.8113% (minimum 95%, Enhanced); midbrain: 62.7119% (minimum 99%, Missing); pancreas: 66.0714% (minimum 95%, Enhanced); parathyroid gland: 78.7234% (minimum 80%, Enhanced); pituitary gland: 80.4348% (minimum 99%, Missing); retina: 92.5000% (minimum 99%, Missing); salivary gland: 72.5490% (minimum 80%, Enhanced); skeletal muscle: 92.5000% (minimum 95%, Enhanced); small intestine: 84.0909% (minimum 95%, Enhanced); smooth muscle: 78.7234% (minimum 95%, Enhanced); spinal cord: 41.5730% (minimum 99%, Missing); thymus: 94.8718% (minimum 95%, Missing); tongue: 90.2439% (minimum 97%, Missing); urinary bladder: 74.0000% (minimum 80%, Enhanced)",-0.00128205,-0.0745098,-0.57427,0,1,partial,5.2,1.4,2.4,"spinal cord: 5.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125864,BFSP1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 62.7119% (minimum 75%, Missing); basal ganglia: 53.6232% (minimum 75%, Missing); cerebral cortex: 57.8125% (minimum 60%, Enhanced); choroid plexus: 56.0606% (minimum 75%, Missing); hippocampal formation: 63.7931% (minimum 75%, Missing); hypothalamus: 61.6667% (minimum 75%, Missing); kidney: 50.6849% (minimum 60%, Enhanced); midbrain: 62.7119% (minimum 75%, Missing); spinal cord: 41.5730% (minimum 75%, Missing)",0.106557,0.17549,-0.33427,0,1,partial,5.2,1.4,2.4,"spinal cord: 5.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125864,BFSP1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 62.7119% (minimum 75%, Missing); basal ganglia: 53.6232% (minimum 75%, Missing); cerebral cortex: 57.8125% (minimum 60%, Enhanced); choroid plexus: 56.0606% (minimum 75%, Missing); hippocampal formation: 63.7931% (minimum 75%, Missing); hypothalamus: 61.6667% (minimum 75%, Missing); kidney: 50.6849% (minimum 60%, Enhanced); midbrain: 62.7119% (minimum 75%, Missing); spinal cord: 41.5730% (minimum 75%, Missing)",0.106557,0.17549,-0.33427,0,1,partial,5.2,1.4,2.4,"spinal cord: 5.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125864,BFSP1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 62.7119% (minimum 75%, Missing); basal ganglia: 53.6232% (minimum 75%, Missing); cerebral cortex: 57.8125% (minimum 60%, Enhanced); choroid plexus: 56.0606% (minimum 75%, Missing); hippocampal formation: 63.7931% (minimum 75%, Missing); hypothalamus: 61.6667% (minimum 75%, Missing); kidney: 50.6849% (minimum 60%, Enhanced); midbrain: 62.7119% (minimum 75%, Missing); spinal cord: 41.5730% (minimum 75%, Missing)",0.106557,0.17549,-0.33427,0,1,partial,5.2,1.4,2.4,"spinal cord: 5.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125864,BFSP1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 74.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.7119% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 53.6232% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.2727% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.8125% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 56.0606% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.7931% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.6667% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.6849% (minimum 75%, Baseline (adaptation disabled)); lung: 69.8113% (minimum 75%, Baseline (adaptation disabled)); midbrain: 62.7119% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.0714% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 41.5730% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 60.6557% (minimum 65%, Baseline (adaptation disabled))",-0.0434426,0.0254902,-0.33427,0,1,partial,5.2,1.4,2.4,"spinal cord: 5.2 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125864,BFSP1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.8018% (minimum 99%, Missing); pancreas: 84.4094% (minimum 98%, Approved)",0.049068,0.03,-0.135906,0,5,partial,19.8,0.2,1.3,"pancreas: 19.8 nTPM (vital, limit 2); choroid plexus: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125888,BANF2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349068,0.3,0.144094,0,5,partial,19.8,0.2,1.3,"pancreas: 19.8 nTPM (vital, limit 2); choroid plexus: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125888,BANF2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349068,0.3,0.144094,0,5,partial,19.8,0.2,1.3,"pancreas: 19.8 nTPM (vital, limit 2); choroid plexus: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125888,BANF2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349068,0.3,0.144094,0,5,partial,19.8,0.2,1.3,"pancreas: 19.8 nTPM (vital, limit 2); choroid plexus: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125888,BANF2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338018,0.298138,0.0940945,0,5,partial,19.8,0.2,1.3,"pancreas: 19.8 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125888,BANF2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.00415959,0,2,partial,2.7,1.1,1.5,,kidney / cells in tubules: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125900,SIRPD,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.248224,0,2,partial,2.7,1.1,1.5,,kidney / cells in tubules: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125900,SIRPD,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.248224,0,2,partial,2.7,1.1,1.5,,kidney / cells in tubules: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125900,SIRPD,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.248224,0,2,partial,2.7,1.1,1.5,,kidney / cells in tubules: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125900,SIRPD,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.324003,0.280803,0.20416,0,2,partial,2.7,1.1,1.5,"bone marrow: 2.7 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125900,SIRPD,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000125903,DEFB129,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000125903,DEFB129,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000125903,DEFB129,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000125903,DEFB129,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000125903,DEFB129,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 95%, Missing); adrenal gland: 91.6667% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 64.7059% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 99%, Missing); choroid plexus: 68.7500% (minimum 99%, Missing); colon: 42.3077% (minimum 97%, Missing); heart muscle: 73.3333% (minimum 99%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 91.6667% (minimum 99%, Missing); kidney: 78.5714% (minimum 99%, Missing); lung: 33.3333% (minimum 99%, Missing); midbrain: 91.6667% (minimum 99%, Missing); pituitary gland: 39.2857% (minimum 99%, Missing); rectum: 91.6667% (minimum 97%, Missing); salivary gland: 10.2804% (minimum 97%, Missing); skin: 91.6667% (minimum 95%, Missing); small intestine: 91.6667% (minimum 99%, Missing); smooth muscle: 64.7059% (minimum 99%, Missing); spinal cord: 91.6667% (minimum 99%, Missing); stomach: 91.6667% (minimum 97%, Missing); thymus: 84.6154% (minimum 95%, Missing); thyroid gland: 84.6154% (minimum 95%, Missing)",-0.4,-0.867196,-0.656667,0,80,unavailable,2.2,9.6,0.9,"salivary gland: 9.6 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125965,GDF5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); basal ganglia: 64.7059% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); colon: 42.3077% (minimum 70%, Missing); heart muscle: 73.3333% (minimum 75%, Missing); lung: 33.3333% (minimum 75%, Missing); pituitary gland: 39.2857% (minimum 75%, Missing); salivary gland: 10.2804% (minimum 70%, Missing); smooth muscle: 64.7059% (minimum 75%, Missing)",-0.1,-0.597196,-0.416667,0,80,unavailable,2.2,9.6,0.9,"salivary gland: 9.6 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125965,GDF5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); basal ganglia: 64.7059% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); colon: 42.3077% (minimum 70%, Missing); heart muscle: 73.3333% (minimum 75%, Missing); lung: 33.3333% (minimum 75%, Missing); pituitary gland: 39.2857% (minimum 75%, Missing); salivary gland: 10.2804% (minimum 70%, Missing); smooth muscle: 64.7059% (minimum 75%, Missing)",-0.1,-0.597196,-0.416667,0,80,unavailable,2.2,9.6,0.9,"salivary gland: 9.6 nTPM (protected, limit 3); lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125965,GDF5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); basal ganglia: 64.7059% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); colon: 42.3077% (minimum 70%, Missing); heart muscle: 73.3333% (minimum 75%, Missing); lung: 33.3333% (minimum 75%, Missing); pituitary gland: 39.2857% (minimum 75%, Missing); salivary gland: 10.2804% (minimum 70%, Missing); smooth muscle: 64.7059% (minimum 75%, Missing)",-0.1,-0.597196,-0.416667,0,80,unavailable,2.2,9.6,0.9,"salivary gland: 9.6 nTPM (protected, limit 3); lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125965,GDF5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Baseline (adaptation disabled)); basal ganglia: 64.7059% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.7500% (minimum 75%, Baseline (adaptation disabled)); colon: 42.3077% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 73.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 33.3333% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 39.2857% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 10.2804% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 64.7059% (minimum 75%, Baseline (adaptation disabled))",-0.1,-0.597196,-0.416667,0,80,unavailable,2.2,9.6,0.9,"salivary gland: 9.6 nTPM (protected, limit 3); lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125965,GDF5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0442363,0.03,0.00710983,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125975,C20orf173,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.344236,0.3,0.24711,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125975,C20orf173,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.344236,0.3,0.24711,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125975,C20orf173,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.344236,0.3,0.24711,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125975,C20orf173,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.344236,0.3,0.24711,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000125975,C20orf173,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.7944% (minimum 95%, Missing); adrenal gland: 62.9344% (minimum 99%, Missing); amygdala: 68.7764% (minimum 99%, Missing); basal ganglia: 67.6349% (minimum 99%, Missing); bone marrow: 34.5339% (minimum 99%, Missing); cerebellum: 58.0071% (minimum 99%, Missing); cerebral cortex: 63.1783% (minimum 99%, Missing); choroid plexus: 77.9904% (minimum 99%, Missing); colon: 61.2782% (minimum 97%, Missing); duodenum: 65.7258% (minimum 99%, Missing); esophagus: 61.0487% (minimum 97%, Missing); heart muscle: 64.1732% (minimum 99%, Missing); hippocampal formation: 67.9167% (minimum 99%, Missing); hypothalamus: 68.2008% (minimum 99%, Missing); kidney: 65.9919% (minimum 99%, Missing); liver: 53.2680% (minimum 99%, Missing); lung: 61.2782% (minimum 99%, Missing); lymph node: 52.9221% (minimum 97%, Missing); midbrain: 67.3554% (minimum 99%, Missing); pancreas: 61.7424% (minimum 99%, Missing); parathyroid gland: 65.7258% (minimum 97%, Missing); pituitary gland: 68.2008% (minimum 99%, Missing); rectum: 62.6923% (minimum 97%, Missing); retina: 59.0580% (minimum 99%, Missing); salivary gland: 61.9772% (minimum 97%, Missing); skeletal muscle: 58.4229% (minimum 99%, Missing); skin: 54.3333% (minimum 95%, Missing); small intestine: 59.9265% (minimum 99%, Missing); smooth muscle: 57.3944% (minimum 99%, Missing); spinal cord: 62.4521% (minimum 99%, Missing); spleen: 52.9221% (minimum 95%, Missing); stomach: 63.6719% (minimum 97%, Missing); thymus: 46.8391% (minimum 95%, Missing); thyroid gland: 61.2782% (minimum 95%, Missing); tongue: 65.4618% (minimum 97%, Missing); urinary bladder: 60.5948% (minimum 97%, Missing)",-0.481609,-0.440779,-0.644661,0,12,partial,30.9,14.5,18.5,"bone marrow: 30.9 nTPM (vital, limit 1); thymus: 18.5 nTPM (manageable, limit 5); spleen: 14.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); liver: 14.3 nTPM (vital, limit 1); skin: 13.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 2); esophagus: 10.4 nTPM (protected, limit 2); lung: 10.3 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); colon: 10.3 nTPM (protected, limit 2); pancreas: 10.1 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 2); heart muscle: 9.1 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 2); parathyroid gland: 8.5 nTPM (protected, limit 2); duodenum: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126216,TUBGCP3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.7944% (minimum 65%, Missing); adrenal gland: 62.9344% (minimum 75%, Missing); amygdala: 68.7764% (minimum 75%, Missing); basal ganglia: 67.6349% (minimum 75%, Missing); bone marrow: 34.5339% (minimum 75%, Missing); cerebellum: 58.0071% (minimum 75%, Missing); cerebral cortex: 63.1783% (minimum 75%, Missing); colon: 61.2782% (minimum 70%, Missing); duodenum: 65.7258% (minimum 75%, Missing); esophagus: 61.0487% (minimum 70%, Missing); heart muscle: 64.1732% (minimum 75%, Missing); hippocampal formation: 67.9167% (minimum 75%, Missing); hypothalamus: 68.2008% (minimum 75%, Missing); kidney: 65.9919% (minimum 75%, Missing); liver: 53.2680% (minimum 75%, Missing); lung: 61.2782% (minimum 75%, Missing); lymph node: 52.9221% (minimum 70%, Missing); midbrain: 67.3554% (minimum 75%, Missing); pancreas: 61.7424% (minimum 75%, Missing); parathyroid gland: 65.7258% (minimum 70%, Missing); pituitary gland: 68.2008% (minimum 75%, Missing); rectum: 62.6923% (minimum 70%, Missing); retina: 59.0580% (minimum 75%, Missing); salivary gland: 61.9772% (minimum 70%, Missing); skeletal muscle: 58.4229% (minimum 75%, Missing); skin: 54.3333% (minimum 65%, Missing); small intestine: 59.9265% (minimum 75%, Missing); smooth muscle: 57.3944% (minimum 75%, Missing); spinal cord: 62.4521% (minimum 75%, Missing); spleen: 52.9221% (minimum 65%, Missing); stomach: 63.6719% (minimum 70%, Missing); thymus: 46.8391% (minimum 65%, Missing); thyroid gland: 61.2782% (minimum 65%, Missing); tongue: 65.4618% (minimum 70%, Missing); urinary bladder: 60.5948% (minimum 70%, Missing)",-0.181609,-0.170779,-0.404661,0,12,partial,30.9,14.5,18.5,"bone marrow: 30.9 nTPM (vital, limit 1); thymus: 18.5 nTPM (manageable, limit 5); spleen: 14.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); liver: 14.3 nTPM (vital, limit 1); skin: 13.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 2); esophagus: 10.4 nTPM (protected, limit 2); lung: 10.3 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); colon: 10.3 nTPM (protected, limit 2); pancreas: 10.1 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 2); heart muscle: 9.1 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 2); parathyroid gland: 8.5 nTPM (protected, limit 2); duodenum: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126216,TUBGCP3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.7944% (minimum 65%, Missing); adrenal gland: 62.9344% (minimum 75%, Missing); amygdala: 68.7764% (minimum 75%, Missing); basal ganglia: 67.6349% (minimum 75%, Missing); bone marrow: 34.5339% (minimum 75%, Missing); cerebellum: 58.0071% (minimum 75%, Missing); cerebral cortex: 63.1783% (minimum 75%, Missing); colon: 61.2782% (minimum 70%, Missing); duodenum: 65.7258% (minimum 75%, Missing); esophagus: 61.0487% (minimum 70%, Missing); heart muscle: 64.1732% (minimum 75%, Missing); hippocampal formation: 67.9167% (minimum 75%, Missing); hypothalamus: 68.2008% (minimum 75%, Missing); kidney: 65.9919% (minimum 75%, Missing); liver: 53.2680% (minimum 75%, Missing); lung: 61.2782% (minimum 75%, Missing); lymph node: 52.9221% (minimum 70%, Missing); midbrain: 67.3554% (minimum 75%, Missing); pancreas: 61.7424% (minimum 75%, Missing); parathyroid gland: 65.7258% (minimum 70%, Missing); pituitary gland: 68.2008% (minimum 75%, Missing); rectum: 62.6923% (minimum 70%, Missing); retina: 59.0580% (minimum 75%, Missing); salivary gland: 61.9772% (minimum 70%, Missing); skeletal muscle: 58.4229% (minimum 75%, Missing); skin: 54.3333% (minimum 65%, Missing); small intestine: 59.9265% (minimum 75%, Missing); smooth muscle: 57.3944% (minimum 75%, Missing); spinal cord: 62.4521% (minimum 75%, Missing); spleen: 52.9221% (minimum 65%, Missing); stomach: 63.6719% (minimum 70%, Missing); thymus: 46.8391% (minimum 65%, Missing); thyroid gland: 61.2782% (minimum 65%, Missing); tongue: 65.4618% (minimum 70%, Missing); urinary bladder: 60.5948% (minimum 70%, Missing)",-0.181609,-0.170779,-0.404661,0,12,partial,30.9,14.5,18.5,"bone marrow: 30.9 nTPM (vital, limit 1); thymus: 18.5 nTPM (manageable, limit 5); spleen: 14.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); liver: 14.3 nTPM (vital, limit 1); skin: 13.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 3); esophagus: 10.4 nTPM (protected, limit 3); lung: 10.3 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); colon: 10.3 nTPM (protected, limit 3); pancreas: 10.1 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 3); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 3); heart muscle: 9.1 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); parathyroid gland: 8.5 nTPM (protected, limit 3); duodenum: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126216,TUBGCP3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.7944% (minimum 65%, Missing); adrenal gland: 62.9344% (minimum 75%, Missing); amygdala: 68.7764% (minimum 75%, Missing); basal ganglia: 67.6349% (minimum 75%, Missing); bone marrow: 34.5339% (minimum 75%, Missing); cerebellum: 58.0071% (minimum 75%, Missing); cerebral cortex: 63.1783% (minimum 75%, Missing); colon: 61.2782% (minimum 70%, Missing); duodenum: 65.7258% (minimum 75%, Missing); esophagus: 61.0487% (minimum 70%, Missing); heart muscle: 64.1732% (minimum 75%, Missing); hippocampal formation: 67.9167% (minimum 75%, Missing); hypothalamus: 68.2008% (minimum 75%, Missing); kidney: 65.9919% (minimum 75%, Missing); liver: 53.2680% (minimum 75%, Missing); lung: 61.2782% (minimum 75%, Missing); lymph node: 52.9221% (minimum 70%, Missing); midbrain: 67.3554% (minimum 75%, Missing); pancreas: 61.7424% (minimum 75%, Missing); parathyroid gland: 65.7258% (minimum 70%, Missing); pituitary gland: 68.2008% (minimum 75%, Missing); rectum: 62.6923% (minimum 70%, Missing); retina: 59.0580% (minimum 75%, Missing); salivary gland: 61.9772% (minimum 70%, Missing); skeletal muscle: 58.4229% (minimum 75%, Missing); skin: 54.3333% (minimum 65%, Missing); small intestine: 59.9265% (minimum 75%, Missing); smooth muscle: 57.3944% (minimum 75%, Missing); spinal cord: 62.4521% (minimum 75%, Missing); spleen: 52.9221% (minimum 65%, Missing); stomach: 63.6719% (minimum 70%, Missing); thymus: 46.8391% (minimum 65%, Missing); thyroid gland: 61.2782% (minimum 65%, Missing); tongue: 65.4618% (minimum 70%, Missing); urinary bladder: 60.5948% (minimum 70%, Missing)",-0.181609,-0.170779,-0.404661,0,12,partial,30.9,14.5,18.5,"bone marrow: 30.9 nTPM (vital, limit 1); thymus: 18.5 nTPM (manageable, limit 5); spleen: 14.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); liver: 14.3 nTPM (vital, limit 1); skin: 13.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 3); esophagus: 10.4 nTPM (protected, limit 3); lung: 10.3 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); colon: 10.3 nTPM (protected, limit 3); pancreas: 10.1 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 3); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 3); heart muscle: 9.1 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); parathyroid gland: 8.5 nTPM (protected, limit 3); duodenum: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126216,TUBGCP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.7944% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.9344% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.7764% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 67.6349% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 34.5339% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 58.0071% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.1783% (minimum 75%, Baseline (adaptation disabled)); colon: 61.2782% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.7258% (minimum 75%, Baseline (adaptation disabled)); esophagus: 61.0487% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.1732% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.9167% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.2008% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.9919% (minimum 75%, Baseline (adaptation disabled)); liver: 53.2680% (minimum 75%, Baseline (adaptation disabled)); lung: 61.2782% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.9221% (minimum 70%, Baseline (adaptation disabled)); midbrain: 67.3554% (minimum 75%, Baseline (adaptation disabled)); pancreas: 61.7424% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.7258% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 68.2008% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.6923% (minimum 70%, Baseline (adaptation disabled)); retina: 59.0580% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.9772% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 58.4229% (minimum 75%, Baseline (adaptation disabled)); skin: 54.3333% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.9265% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.3944% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.4521% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.9221% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.6719% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.8391% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 61.2782% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.4618% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.5948% (minimum 70%, Baseline (adaptation disabled))",-0.181609,-0.170779,-0.404661,0,12,partial,30.9,14.5,18.5,"bone marrow: 30.9 nTPM (vital, limit 1); thymus: 18.5 nTPM (manageable, limit 5); spleen: 14.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); liver: 14.3 nTPM (vital, limit 1); skin: 13.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 3); esophagus: 10.4 nTPM (protected, limit 3); lung: 10.3 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); colon: 10.3 nTPM (protected, limit 3); pancreas: 10.1 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 3); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 3); heart muscle: 9.1 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); parathyroid gland: 8.5 nTPM (protected, limit 3); duodenum: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126216,TUBGCP3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 46.7626% (minimum 95%, Missing); adrenal gland: 38.0117% (minimum 99%, Missing); amygdala: 52.8455% (minimum 99%, Missing); basal ganglia: 56.5217% (minimum 99%, Missing); bone marrow: 32.1782% (minimum 99%, Uncertain); cerebellum: 61.9048% (minimum 99%, Missing); cerebral cortex: 59.0909% (minimum 99%, Missing); choroid plexus: 54.6218% (minimum 99%, Missing); colon: 51.1811% (minimum 97%, Missing); duodenum: 53.2787% (minimum 99%, Missing); esophagus: 63.1068% (minimum 97%, Uncertain); heart muscle: 60.1852% (minimum 99%, Missing); hippocampal formation: 57.0175% (minimum 99%, Missing); hypothalamus: 55.5556% (minimum 99%, Missing); kidney: 32.3383% (minimum 99%, Missing); liver: 11.7754% (minimum 99%, Missing); lung: 37.1429% (minimum 99%, Missing); lymph node: 16.7526% (minimum 97%, Missing); midbrain: 48.8722% (minimum 99%, Missing); pancreas: 41.9355% (minimum 99%, Missing); parathyroid gland: 82.2785% (minimum 97%, Missing); pituitary gland: 54.6218% (minimum 99%, Missing); rectum: 51.1811% (minimum 97%, Missing); retina: 60.7477% (minimum 99%, Missing); salivary gland: 46.0993% (minimum 97%, Uncertain); skeletal muscle: 60.1852% (minimum 99%, Missing); skin: 61.3208% (minimum 95%, Uncertain); small intestine: 33.6788% (minimum 99%, Missing); smooth muscle: 60.7477% (minimum 99%, Uncertain); spinal cord: 46.4286% (minimum 99%, Missing); spleen: 18.8953% (minimum 95%, Missing); stomach: 46.0993% (minimum 97%, Missing); thymus: 34.7594% (minimum 95%, Missing); thyroid gland: 48.5075% (minimum 95%, Missing); tongue: 76.4706% (minimum 97%, Missing); urinary bladder: 48.5075% (minimum 97%, Missing)",-0.761047,-0.802474,-0.872246,0,1,partial,48.7,32.3,27.9,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 2); spleen: 27.9 nTPM (manageable, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); thymus: 12.2 nTPM (manageable, limit 5); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 2); salivary gland: 7.6 nTPM (protected, limit 2); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); urinary bladder: 6.9 nTPM (protected, limit 2); thyroid gland: 6.9 nTPM (manageable, limit 5); midbrain: 6.8 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); colon: 6.2 nTPM (protected, limit 2); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126246,IGFLR1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 46.7626% (minimum 65%, Missing); adrenal gland: 38.0117% (minimum 75%, Missing); amygdala: 52.8455% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); bone marrow: 32.1782% (minimum 75%, Uncertain); cerebellum: 61.9048% (minimum 75%, Missing); cerebral cortex: 59.0909% (minimum 75%, Missing); choroid plexus: 54.6218% (minimum 75%, Missing); colon: 51.1811% (minimum 70%, Missing); duodenum: 53.2787% (minimum 75%, Missing); esophagus: 63.1068% (minimum 70%, Uncertain); heart muscle: 60.1852% (minimum 75%, Missing); hippocampal formation: 57.0175% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); kidney: 32.3383% (minimum 75%, Missing); liver: 11.7754% (minimum 75%, Missing); lung: 37.1429% (minimum 75%, Missing); lymph node: 16.7526% (minimum 70%, Missing); midbrain: 48.8722% (minimum 75%, Missing); pancreas: 41.9355% (minimum 75%, Missing); pituitary gland: 54.6218% (minimum 75%, Missing); rectum: 51.1811% (minimum 70%, Missing); retina: 60.7477% (minimum 75%, Missing); salivary gland: 46.0993% (minimum 70%, Uncertain); skeletal muscle: 60.1852% (minimum 75%, Missing); skin: 61.3208% (minimum 65%, Uncertain); small intestine: 33.6788% (minimum 75%, Missing); smooth muscle: 60.7477% (minimum 75%, Uncertain); spinal cord: 46.4286% (minimum 75%, Missing); spleen: 18.8953% (minimum 65%, Missing); stomach: 46.0993% (minimum 70%, Missing); thymus: 34.7594% (minimum 65%, Missing); thyroid gland: 48.5075% (minimum 65%, Missing); urinary bladder: 48.5075% (minimum 70%, Missing)",-0.461047,-0.532474,-0.632246,0,1,partial,48.7,32.3,27.9,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 2); spleen: 27.9 nTPM (manageable, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); thymus: 12.2 nTPM (manageable, limit 5); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 2); salivary gland: 7.6 nTPM (protected, limit 2); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); urinary bladder: 6.9 nTPM (protected, limit 2); thyroid gland: 6.9 nTPM (manageable, limit 5); midbrain: 6.8 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); colon: 6.2 nTPM (protected, limit 2); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126246,IGFLR1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 46.7626% (minimum 65%, Missing); adrenal gland: 38.0117% (minimum 75%, Missing); amygdala: 52.8455% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); bone marrow: 32.1782% (minimum 75%, Uncertain); cerebellum: 61.9048% (minimum 75%, Missing); cerebral cortex: 59.0909% (minimum 75%, Missing); choroid plexus: 54.6218% (minimum 75%, Missing); colon: 51.1811% (minimum 70%, Missing); duodenum: 53.2787% (minimum 75%, Missing); esophagus: 63.1068% (minimum 70%, Uncertain); heart muscle: 60.1852% (minimum 75%, Missing); hippocampal formation: 57.0175% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); kidney: 32.3383% (minimum 75%, Missing); liver: 11.7754% (minimum 75%, Missing); lung: 37.1429% (minimum 75%, Missing); lymph node: 16.7526% (minimum 70%, Missing); midbrain: 48.8722% (minimum 75%, Missing); pancreas: 41.9355% (minimum 75%, Missing); pituitary gland: 54.6218% (minimum 75%, Missing); rectum: 51.1811% (minimum 70%, Missing); retina: 60.7477% (minimum 75%, Missing); salivary gland: 46.0993% (minimum 70%, Uncertain); skeletal muscle: 60.1852% (minimum 75%, Missing); skin: 61.3208% (minimum 65%, Uncertain); small intestine: 33.6788% (minimum 75%, Missing); smooth muscle: 60.7477% (minimum 75%, Uncertain); spinal cord: 46.4286% (minimum 75%, Missing); spleen: 18.8953% (minimum 65%, Missing); stomach: 46.0993% (minimum 70%, Missing); thymus: 34.7594% (minimum 65%, Missing); thyroid gland: 48.5075% (minimum 65%, Missing); urinary bladder: 48.5075% (minimum 70%, Missing)",-0.461047,-0.532474,-0.632246,0,1,partial,48.7,32.3,27.9,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 3); spleen: 27.9 nTPM (manageable, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); thymus: 12.2 nTPM (manageable, limit 5); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 3); salivary gland: 7.6 nTPM (protected, limit 3); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); urinary bladder: 6.9 nTPM (protected, limit 3); thyroid gland: 6.9 nTPM (manageable, limit 5); midbrain: 6.8 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); colon: 6.2 nTPM (protected, limit 3); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126246,IGFLR1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 46.7626% (minimum 65%, Missing); adrenal gland: 38.0117% (minimum 75%, Missing); amygdala: 52.8455% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); bone marrow: 32.1782% (minimum 75%, Uncertain); cerebellum: 61.9048% (minimum 75%, Missing); cerebral cortex: 59.0909% (minimum 75%, Missing); choroid plexus: 54.6218% (minimum 75%, Missing); colon: 51.1811% (minimum 70%, Missing); duodenum: 53.2787% (minimum 75%, Missing); esophagus: 63.1068% (minimum 70%, Uncertain); heart muscle: 60.1852% (minimum 75%, Missing); hippocampal formation: 57.0175% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); kidney: 32.3383% (minimum 75%, Missing); liver: 11.7754% (minimum 75%, Missing); lung: 37.1429% (minimum 75%, Missing); lymph node: 16.7526% (minimum 70%, Missing); midbrain: 48.8722% (minimum 75%, Missing); pancreas: 41.9355% (minimum 75%, Missing); pituitary gland: 54.6218% (minimum 75%, Missing); rectum: 51.1811% (minimum 70%, Missing); retina: 60.7477% (minimum 75%, Missing); salivary gland: 46.0993% (minimum 70%, Uncertain); skeletal muscle: 60.1852% (minimum 75%, Missing); skin: 61.3208% (minimum 65%, Uncertain); small intestine: 33.6788% (minimum 75%, Missing); smooth muscle: 60.7477% (minimum 75%, Uncertain); spinal cord: 46.4286% (minimum 75%, Missing); spleen: 18.8953% (minimum 65%, Missing); stomach: 46.0993% (minimum 70%, Missing); thymus: 34.7594% (minimum 65%, Missing); thyroid gland: 48.5075% (minimum 65%, Missing); urinary bladder: 48.5075% (minimum 70%, Missing)",-0.461047,-0.532474,-0.632246,0,1,partial,48.7,32.3,27.9,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 3); spleen: 27.9 nTPM (manageable, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); thymus: 12.2 nTPM (manageable, limit 5); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 3); salivary gland: 7.6 nTPM (protected, limit 3); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); urinary bladder: 6.9 nTPM (protected, limit 3); thyroid gland: 6.9 nTPM (manageable, limit 5); midbrain: 6.8 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); colon: 6.2 nTPM (protected, limit 3); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126246,IGFLR1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 46.7626% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 38.0117% (minimum 75%, Baseline (adaptation disabled)); amygdala: 52.8455% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.5217% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 32.1782% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.9048% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 59.0909% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 54.6218% (minimum 75%, Baseline (adaptation disabled)); colon: 51.1811% (minimum 70%, Baseline (adaptation disabled)); duodenum: 53.2787% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.1068% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.1852% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.0175% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.5556% (minimum 75%, Baseline (adaptation disabled)); kidney: 32.3383% (minimum 75%, Baseline (adaptation disabled)); liver: 11.7754% (minimum 75%, Baseline (adaptation disabled)); lung: 37.1429% (minimum 75%, Baseline (adaptation disabled)); lymph node: 16.7526% (minimum 70%, Baseline (adaptation disabled)); midbrain: 48.8722% (minimum 75%, Baseline (adaptation disabled)); pancreas: 41.9355% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 54.6218% (minimum 75%, Baseline (adaptation disabled)); rectum: 51.1811% (minimum 70%, Baseline (adaptation disabled)); retina: 60.7477% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 46.0993% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.1852% (minimum 75%, Baseline (adaptation disabled)); skin: 61.3208% (minimum 65%, Baseline (adaptation disabled)); small intestine: 33.6788% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.7477% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 46.4286% (minimum 75%, Baseline (adaptation disabled)); spleen: 18.8953% (minimum 65%, Baseline (adaptation disabled)); stomach: 46.0993% (minimum 70%, Baseline (adaptation disabled)); thymus: 34.7594% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 48.5075% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 48.5075% (minimum 70%, Baseline (adaptation disabled))",-0.461047,-0.532474,-0.632246,0,1,partial,48.7,32.3,27.9,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 3); spleen: 27.9 nTPM (manageable, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); thymus: 12.2 nTPM (manageable, limit 5); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 3); salivary gland: 7.6 nTPM (protected, limit 3); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); urinary bladder: 6.9 nTPM (protected, limit 3); thyroid gland: 6.9 nTPM (manageable, limit 5); midbrain: 6.8 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); colon: 6.2 nTPM (protected, limit 3); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126246,IGFLR1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0474359,0.03,0.00914384,0,3,partial,1.4,0.9,1.7,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126467,TSKS,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.347436,0.3,0.249144,0,3,partial,1.4,0.9,1.7,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126467,TSKS,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.347436,0.3,0.249144,0,3,partial,1.4,0.9,1.7,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126467,TSKS,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.347436,0.3,0.249144,0,3,partial,1.4,0.9,1.7,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126467,TSKS,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335642,0.292347,0.238146,0,3,partial,1.4,0.9,1.7,"heart muscle: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126467,TSKS,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.3793% (minimum 98%, Approved); heart muscle: 55.2083% (minimum 98%, Approved); pancreas: 22.7468% (minimum 98%, Approved); salivary gland: 0.0112% (minimum 95%, Approved); skin: 88.3333% (minimum 90%, Approved)",-0.0166667,-0.949888,-0.752532,0,3,partial,18,47123.7,0.7,"salivary gland: 47123.7 nTPM (protected, limit 4); pancreas: 18 nTPM (vital, limit 2); heart muscle: 4.3 nTPM (vital, limit 2)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126550,HTN1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 55.2083% (minimum 70%, Approved); pancreas: 22.7468% (minimum 70%, Approved); salivary gland: 0.0112% (minimum 65%, Approved)",0.283333,-0.649888,-0.472532,0,3,partial,18,47123.7,0.7,"salivary gland: 47123.7 nTPM (protected, limit 4); pancreas: 18 nTPM (vital, limit 2); heart muscle: 4.3 nTPM (vital, limit 2)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126550,HTN1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 55.2083% (minimum 70%, Approved); pancreas: 22.7468% (minimum 70%, Approved); salivary gland: 0.0112% (minimum 65%, Approved)",0.283333,-0.649888,-0.472532,0,3,partial,18,47123.7,0.7,"salivary gland: 47123.7 nTPM (protected, limit 4); pancreas: 18 nTPM (vital, limit 2); heart muscle: 4.3 nTPM (vital, limit 2)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126550,HTN1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 55.2083% (minimum 70%, Approved); pancreas: 22.7468% (minimum 70%, Approved); salivary gland: 0.0112% (minimum 65%, Approved)",0.283333,-0.649888,-0.472532,0,3,partial,18,47123.7,0.7,"salivary gland: 47123.7 nTPM (protected, limit 4); pancreas: 18 nTPM (vital, limit 2); heart muscle: 4.3 nTPM (vital, limit 2)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126550,HTN1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 55.2083% (minimum 75%, Baseline (adaptation disabled)); pancreas: 22.7468% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 0.0112% (minimum 70%, Baseline (adaptation disabled))",0.233333,-0.699888,-0.522532,0,3,partial,18,47123.7,0.7,"salivary gland: 47123.7 nTPM (protected, limit 3); pancreas: 18 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126550,HTN1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0.1,0.1,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126752,SSX1,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.1,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126752,SSX1,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.1,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126752,SSX1,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.1,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126752,SSX1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.322973,0.286301,0.236301,0,2,partial,0.1,0.1,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126752,SSX1,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 36.5801% (minimum 99%, Missing); cerebral cortex: 97.6879% (minimum 99%, Missing); colon: 75.7848% (minimum 97%, Missing); duodenum: 77.5229% (minimum 99%, Missing); esophagus: 77.1689% (minimum 97%, Missing); kidney: 98.8304% (minimum 99%, Missing); lung: 96.0227% (minimum 99%, Missing); lymph node: 49.2711% (minimum 97%, Missing); rectum: 72.2222% (minimum 97%, Missing); skin: 84.5000% (minimum 95%, Missing); small intestine: 78.9720% (minimum 99%, Missing); smooth muscle: 86.6667% (minimum 99%, Missing); spleen: 86.6667% (minimum 95%, Missing); stomach: 85.3535% (minimum 97%, Missing); thymus: 29.2388% (minimum 95%, Missing); urinary bladder: 89.4180% (minimum 97%, Missing)",-0.657612,-0.477289,-0.624199,0,17,partial,29.3,17.4,40.9,"thymus: 40.9 nTPM (manageable, limit 5); bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 2); rectum: 6.5 nTPM (protected, limit 2); colon: 5.4 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126787,DLGAP5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 36.5801% (minimum 75%, Missing); lymph node: 49.2711% (minimum 70%, Missing); thymus: 29.2388% (minimum 65%, Missing)",-0.357612,-0.207289,-0.384199,0,17,partial,29.3,17.4,40.9,"thymus: 40.9 nTPM (manageable, limit 5); bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 2); rectum: 6.5 nTPM (protected, limit 2); colon: 5.4 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126787,DLGAP5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 36.5801% (minimum 75%, Missing); lymph node: 49.2711% (minimum 70%, Missing); thymus: 29.2388% (minimum 65%, Missing)",-0.357612,-0.207289,-0.384199,0,17,partial,29.3,17.4,40.9,"thymus: 40.9 nTPM (manageable, limit 5); bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 3); rectum: 6.5 nTPM (protected, limit 3); colon: 5.4 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126787,DLGAP5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 36.5801% (minimum 75%, Missing); lymph node: 49.2711% (minimum 70%, Missing); thymus: 29.2388% (minimum 65%, Missing)",-0.357612,-0.207289,-0.384199,0,17,partial,29.3,17.4,40.9,"thymus: 40.9 nTPM (manageable, limit 5); bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 3); rectum: 6.5 nTPM (protected, limit 3); colon: 5.4 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126787,DLGAP5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 36.5801% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.2711% (minimum 70%, Baseline (adaptation disabled)); thymus: 29.2388% (minimum 65%, Baseline (adaptation disabled))",-0.357612,-0.207289,-0.384199,0,17,partial,29.3,17.4,40.9,"thymus: 40.9 nTPM (manageable, limit 5); bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 3); rectum: 6.5 nTPM (protected, limit 3); colon: 5.4 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126787,DLGAP5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126856,PRDM7,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126856,PRDM7,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126856,PRDM7,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126856,PRDM7,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000126856,PRDM7,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 92.6606% (minimum 95%, Enhanced); amygdala: 98.0583% (minimum 99%, Missing); basal ganglia: 98.0583% (minimum 99%, Missing); heart muscle: 66.4474% (minimum 95%, Enhanced); hippocampal formation: 97.1154% (minimum 99%, Missing); hypothalamus: 97.1154% (minimum 99%, Missing); kidney: 74.8148% (minimum 95%, Enhanced); liver: 94.3925% (minimum 95%, Enhanced); midbrain: 94.3925% (minimum 99%, Missing); pancreas: 84.1667% (minimum 95%, Enhanced); pituitary gland: 97.1154% (minimum 99%, Missing); skeletal muscle: 76.5152% (minimum 95%, Enhanced); spinal cord: 97.1154% (minimum 99%, Missing); thymus: 77.6923% (minimum 95%, Missing)",-0.173077,0.03,-0.285526,0,2,partial,5.1,0.8,2.9,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,True,Pinned heart RNA 5.1 nTPM coexists with Enhanced Not detected cardiomyocyte IHC. Cell of origin and antigen presentation remain unresolved. Reviewed clinical cardiac events have confounding and uncertain attribution; no blanket cardiac-safety claim. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/audits/ctag2-heart-evidence/,ENSG00000126890,CTAG2,admission_only,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.126923,0.3,0.0644737,0,2,partial,5.1,0.8,2.9,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,True,Pinned heart RNA 5.1 nTPM coexists with Enhanced Not detected cardiomyocyte IHC. Cell of origin and antigen presentation remain unresolved. Reviewed clinical cardiac events have confounding and uncertain attribution; no blanket cardiac-safety claim. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/audits/ctag2-heart-evidence/,ENSG00000126890,CTAG2,selectivity_revised,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.126923,0.3,0.0644737,0,2,partial,5.1,0.8,2.9,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,True,Pinned heart RNA 5.1 nTPM coexists with Enhanced Not detected cardiomyocyte IHC. Cell of origin and antigen presentation remain unresolved. Reviewed clinical cardiac events have confounding and uncertain attribution; no blanket cardiac-safety claim. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/audits/ctag2-heart-evidence/,ENSG00000126890,CTAG2,grid_revised,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.126923,0.3,0.0644737,0,2,partial,5.1,0.8,2.9,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,True,The historical categorical somatic-RNA holdback is superseded for this numerical research screen. Retention still requires every current RNA/selectivity/IHC/coverage gate; this adjudication cannot bypass a failing observation.,True,Pinned heart RNA 5.1 nTPM coexists with Enhanced Not detected cardiomyocyte IHC. Cell of origin and antigen presentation remain unresolved. Reviewed clinical cardiac events have confounding and uncertain attribution; no blanket cardiac-safety claim. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/audits/ctag2-heart-evidence/,ENSG00000126890,CTAG2,current_adaptive,True,True,True,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 66.4474% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.8148% (minimum 75%, Baseline (adaptation disabled))",0.126923,0.226606,-0.0855263,0,2,partial,5.1,0.8,2.9,"heart muscle: 5.1 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,True,The historical categorical somatic-RNA holdback is superseded for this numerical research screen. Retention still requires every current RNA/selectivity/IHC/coverage gate; this adjudication cannot bypass a failing observation.,True,Pinned heart RNA 5.1 nTPM coexists with Enhanced Not detected cardiomyocyte IHC. Cell of origin and antigen presentation remain unresolved. Reviewed clinical cardiac events have confounding and uncertain attribution; no blanket cardiac-safety claim. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/audits/ctag2-heart-evidence/,ENSG00000126890,CTAG2,current_fixed,True,True,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.7568% (minimum 99%, Missing); amygdala: 89.3883% (minimum 99%, Missing); basal ganglia: 91.7949% (minimum 99%, Missing); cerebral cortex: 91.2102% (minimum 99%, Missing); choroid plexus: 95.3395% (minimum 99%, Missing); esophagus: 91.9127% (minimum 97%, Missing); heart muscle: 88.8337% (minimum 99%, Missing); hippocampal formation: 91.9127% (minimum 99%, Missing); hypothalamus: 92.3871% (minimum 99%, Missing); midbrain: 91.0941% (minimum 99%, Missing); pancreas: 98.0822% (minimum 99%, Missing); pituitary gland: 97.0190% (minimum 99%, Missing); retina: 89.1656% (minimum 99%, Missing); skeletal muscle: 45.1735% (minimum 99%, Missing); smooth muscle: 98.3516% (minimum 99%, Missing); spinal cord: 96.7568% (minimum 99%, Missing); thyroid gland: 91.3265% (minimum 95%, Missing); tongue: 62.5874% (minimum 97%, Missing)",-0.0367347,-0.344126,-0.538265,0,80,unavailable,86.9,42.8,6.8,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 2); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127252,PLAAT1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 45.1735% (minimum 75%, Missing); tongue: 62.5874% (minimum 70%, Missing)",0.263265,-0.0741259,-0.298265,0,80,unavailable,86.9,42.8,6.8,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 2); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127252,PLAAT1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 45.1735% (minimum 75%, Missing); tongue: 62.5874% (minimum 70%, Missing)",0.263265,-0.0741259,-0.298265,0,80,unavailable,86.9,42.8,6.8,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 3); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 3); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127252,PLAAT1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 45.1735% (minimum 75%, Missing); tongue: 62.5874% (minimum 70%, Missing)",0.263265,-0.0741259,-0.298265,0,80,unavailable,86.9,42.8,6.8,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 3); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 3); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127252,PLAAT1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 45.1735% (minimum 75%, Baseline (adaptation disabled)); tongue: 62.5874% (minimum 70%, Baseline (adaptation disabled))",0.263265,-0.0741259,-0.298265,0,80,unavailable,86.9,42.8,6.8,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 3); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 3); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127252,PLAAT1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.3333% (minimum 95%, Missing); adrenal gland: 72.7273% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 72.7273% (minimum 99%, Missing); bone marrow: 47.0588% (minimum 99%, Missing); cerebral cortex: 80.0000% (minimum 99%, Missing); colon: 53.3333% (minimum 97%, Missing); esophagus: 61.5385% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 72.7273% (minimum 99%, Missing); hypothalamus: 72.7273% (minimum 99%, Missing); kidney: 53.3333% (minimum 99%, Missing); liver: 40.0000% (minimum 99%, Missing); lung: 44.4444% (minimum 99%, Missing); lymph node: 61.5385% (minimum 97%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 50.0000% (minimum 99%, Missing); parathyroid gland: 88.8889% (minimum 97%, Missing); pituitary gland: 40.0000% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 88.8889% (minimum 99%, Missing); salivary gland: 53.3333% (minimum 97%, Missing); skeletal muscle: 80.0000% (minimum 99%, Missing); skin: 61.5385% (minimum 95%, Missing); small intestine: 40.0000% (minimum 99%, Missing); smooth muscle: 88.8889% (minimum 99%, Missing); spinal cord: 57.1429% (minimum 99%, Missing); spleen: 32.0000% (minimum 95%, Missing); stomach: 53.3333% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 53.3333% (minimum 95%, Missing); urinary bladder: 61.5385% (minimum 97%, Missing)",-0.63,-0.436667,-0.59,0,80,unavailable,1.2,0.7,1.7,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127311,HELB,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.3333% (minimum 65%, Missing); adrenal gland: 72.7273% (minimum 75%, Missing); basal ganglia: 72.7273% (minimum 75%, Missing); bone marrow: 47.0588% (minimum 75%, Missing); colon: 53.3333% (minimum 70%, Missing); esophagus: 61.5385% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 72.7273% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); kidney: 53.3333% (minimum 75%, Missing); liver: 40.0000% (minimum 75%, Missing); lung: 44.4444% (minimum 75%, Missing); lymph node: 61.5385% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); pituitary gland: 40.0000% (minimum 75%, Missing); salivary gland: 53.3333% (minimum 70%, Missing); skin: 61.5385% (minimum 65%, Missing); small intestine: 40.0000% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing); spleen: 32.0000% (minimum 65%, Missing); stomach: 53.3333% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 61.5385% (minimum 70%, Missing)",-0.33,-0.166667,-0.35,0,80,unavailable,1.2,0.7,1.7,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127311,HELB,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.3333% (minimum 65%, Missing); adrenal gland: 72.7273% (minimum 75%, Missing); basal ganglia: 72.7273% (minimum 75%, Missing); bone marrow: 47.0588% (minimum 75%, Missing); colon: 53.3333% (minimum 70%, Missing); esophagus: 61.5385% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 72.7273% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); kidney: 53.3333% (minimum 75%, Missing); liver: 40.0000% (minimum 75%, Missing); lung: 44.4444% (minimum 75%, Missing); lymph node: 61.5385% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); pituitary gland: 40.0000% (minimum 75%, Missing); salivary gland: 53.3333% (minimum 70%, Missing); skin: 61.5385% (minimum 65%, Missing); small intestine: 40.0000% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing); spleen: 32.0000% (minimum 65%, Missing); stomach: 53.3333% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 61.5385% (minimum 70%, Missing)",-0.33,-0.166667,-0.35,0,80,unavailable,1.2,0.7,1.7,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127311,HELB,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.3333% (minimum 65%, Missing); adrenal gland: 72.7273% (minimum 75%, Missing); basal ganglia: 72.7273% (minimum 75%, Missing); bone marrow: 47.0588% (minimum 75%, Missing); colon: 53.3333% (minimum 70%, Missing); esophagus: 61.5385% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 72.7273% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); kidney: 53.3333% (minimum 75%, Missing); liver: 40.0000% (minimum 75%, Missing); lung: 44.4444% (minimum 75%, Missing); lymph node: 61.5385% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); pituitary gland: 40.0000% (minimum 75%, Missing); salivary gland: 53.3333% (minimum 70%, Missing); skin: 61.5385% (minimum 65%, Missing); small intestine: 40.0000% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing); spleen: 32.0000% (minimum 65%, Missing); stomach: 53.3333% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 61.5385% (minimum 70%, Missing)",-0.33,-0.166667,-0.35,0,80,unavailable,1.2,0.7,1.7,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127311,HELB,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.3333% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 72.7273% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 72.7273% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 47.0588% (minimum 75%, Baseline (adaptation disabled)); colon: 53.3333% (minimum 70%, Baseline (adaptation disabled)); esophagus: 61.5385% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.7273% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.7273% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.3333% (minimum 75%, Baseline (adaptation disabled)); liver: 40.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 44.4444% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.5385% (minimum 70%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 50.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 40.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.3333% (minimum 70%, Baseline (adaptation disabled)); skin: 61.5385% (minimum 65%, Baseline (adaptation disabled)); small intestine: 40.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.1429% (minimum 75%, Baseline (adaptation disabled)); spleen: 32.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 53.3333% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.3333% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 61.5385% (minimum 70%, Baseline (adaptation disabled))",-0.33,-0.166667,-0.35,0,80,unavailable,1.2,0.7,1.7,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127311,HELB,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.8226% (minimum 95%, Missing); adrenal gland: 75.7895% (minimum 99%, Missing); amygdala: 80.5369% (minimum 99%, Missing); basal ganglia: 80.3571% (minimum 99%, Missing); bone marrow: 44.3350% (minimum 99%, Missing); cerebellum: 68.4411% (minimum 99%, Missing); cerebral cortex: 77.2532% (minimum 99%, Missing); choroid plexus: 70.7269% (minimum 99%, Missing); colon: 75.1566% (minimum 97%, Missing); duodenum: 73.3198% (minimum 99%, Missing); esophagus: 76.1099% (minimum 97%, Missing); heart muscle: 77.0878% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 78.7746% (minimum 99%, Missing); kidney: 70.8661% (minimum 99%, Missing); liver: 71.4286% (minimum 99%, Missing); lung: 80.7175% (minimum 99%, Missing); lymph node: 62.0690% (minimum 97%, Missing); midbrain: 80.1782% (minimum 99%, Missing); pancreas: 68.1818% (minimum 99%, Missing); parathyroid gland: 76.9231% (minimum 97%, Missing); pituitary gland: 78.4314% (minimum 99%, Missing); rectum: 73.0223% (minimum 97%, Missing); retina: 64.9819% (minimum 99%, Missing); salivary gland: 75.4717% (minimum 97%, Missing); skeletal muscle: 72.2892% (minimum 99%, Missing); skin: 76.5957% (minimum 95%, Missing); small intestine: 73.3198% (minimum 99%, Missing); smooth muscle: 81.6327% (minimum 99%, Missing); spinal cord: 78.2609% (minimum 99%, Missing); spleen: 77.0878% (minimum 95%, Missing); stomach: 77.0878% (minimum 97%, Missing); thymus: 58.8235% (minimum 95%, Missing); thyroid gland: 72.8745% (minimum 95%, Missing); tongue: 65.8135% (minimum 97%, Missing); urinary bladder: 76.7591% (minimum 97%, Missing)",-0.361765,-0.34931,-0.54665,0,80,unavailable,45.2,22,25.2,"bone marrow: 45.2 nTPM (vital, limit 1); thymus: 25.2 nTPM (manageable, limit 5); lymph node: 22 nTPM (protected, limit 2); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 2); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); rectum: 13.3 nTPM (protected, limit 2); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 2); salivary gland: 11.7 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 2); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.8 nTPM (protected, limit 2); stomach: 10.7 nTPM (protected, limit 2); heart muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127337,YEATS4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 44.3350% (minimum 75%, Missing); cerebellum: 68.4411% (minimum 75%, Missing); choroid plexus: 70.7269% (minimum 75%, Missing); duodenum: 73.3198% (minimum 75%, Missing); kidney: 70.8661% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lymph node: 62.0690% (minimum 70%, Missing); pancreas: 68.1818% (minimum 75%, Missing); retina: 64.9819% (minimum 75%, Missing); skeletal muscle: 72.2892% (minimum 75%, Missing); small intestine: 73.3198% (minimum 75%, Missing); thymus: 58.8235% (minimum 65%, Missing); tongue: 65.8135% (minimum 70%, Missing)",-0.0617647,-0.0793103,-0.30665,0,80,unavailable,45.2,22,25.2,"bone marrow: 45.2 nTPM (vital, limit 1); thymus: 25.2 nTPM (manageable, limit 5); lymph node: 22 nTPM (protected, limit 2); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 2); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); rectum: 13.3 nTPM (protected, limit 2); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 2); salivary gland: 11.7 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 2); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.8 nTPM (protected, limit 2); stomach: 10.7 nTPM (protected, limit 2); heart muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127337,YEATS4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 44.3350% (minimum 75%, Missing); cerebellum: 68.4411% (minimum 75%, Missing); choroid plexus: 70.7269% (minimum 75%, Missing); duodenum: 73.3198% (minimum 75%, Missing); kidney: 70.8661% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lymph node: 62.0690% (minimum 70%, Missing); pancreas: 68.1818% (minimum 75%, Missing); retina: 64.9819% (minimum 75%, Missing); skeletal muscle: 72.2892% (minimum 75%, Missing); small intestine: 73.3198% (minimum 75%, Missing); thymus: 58.8235% (minimum 65%, Missing); tongue: 65.8135% (minimum 70%, Missing)",-0.0617647,-0.0793103,-0.30665,0,80,unavailable,45.2,22,25.2,"bone marrow: 45.2 nTPM (vital, limit 1); thymus: 25.2 nTPM (manageable, limit 5); lymph node: 22 nTPM (protected, limit 3); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 3); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); rectum: 13.3 nTPM (protected, limit 3); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 3); salivary gland: 11.7 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 3); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.8 nTPM (protected, limit 3); stomach: 10.7 nTPM (protected, limit 3); heart muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127337,YEATS4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 44.3350% (minimum 75%, Missing); cerebellum: 68.4411% (minimum 75%, Missing); choroid plexus: 70.7269% (minimum 75%, Missing); duodenum: 73.3198% (minimum 75%, Missing); kidney: 70.8661% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lymph node: 62.0690% (minimum 70%, Missing); pancreas: 68.1818% (minimum 75%, Missing); retina: 64.9819% (minimum 75%, Missing); skeletal muscle: 72.2892% (minimum 75%, Missing); small intestine: 73.3198% (minimum 75%, Missing); thymus: 58.8235% (minimum 65%, Missing); tongue: 65.8135% (minimum 70%, Missing)",-0.0617647,-0.0793103,-0.30665,0,80,unavailable,45.2,22,25.2,"bone marrow: 45.2 nTPM (vital, limit 1); thymus: 25.2 nTPM (manageable, limit 5); lymph node: 22 nTPM (protected, limit 3); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 3); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); rectum: 13.3 nTPM (protected, limit 3); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 3); salivary gland: 11.7 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 3); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.8 nTPM (protected, limit 3); stomach: 10.7 nTPM (protected, limit 3); heart muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127337,YEATS4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 44.3350% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.4411% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.7269% (minimum 75%, Baseline (adaptation disabled)); duodenum: 73.3198% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.8661% (minimum 75%, Baseline (adaptation disabled)); liver: 71.4286% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.0690% (minimum 70%, Baseline (adaptation disabled)); pancreas: 68.1818% (minimum 75%, Baseline (adaptation disabled)); retina: 64.9819% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 72.2892% (minimum 75%, Baseline (adaptation disabled)); small intestine: 73.3198% (minimum 75%, Baseline (adaptation disabled)); thymus: 58.8235% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.8135% (minimum 70%, Baseline (adaptation disabled))",-0.0617647,-0.0793103,-0.30665,0,80,unavailable,45.2,22,25.2,"bone marrow: 45.2 nTPM (vital, limit 1); thymus: 25.2 nTPM (manageable, limit 5); lymph node: 22 nTPM (protected, limit 3); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 3); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); rectum: 13.3 nTPM (protected, limit 3); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 3); salivary gland: 11.7 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 3); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.8 nTPM (protected, limit 3); stomach: 10.7 nTPM (protected, limit 3); heart muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127337,YEATS4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.5122% (minimum 99%, Missing); amygdala: 94.5122% (minimum 99%, Missing); basal ganglia: 96.8750% (minimum 99%, Missing); bone marrow: 71.7593% (minimum 99%, Missing); cerebellum: 93.3735% (minimum 99%, Missing); cerebral cortex: 92.8144% (minimum 99%, Missing); colon: 95.6790% (minimum 97%, Missing); duodenum: 94.5122% (minimum 99%, Missing); esophagus: 91.7160% (minimum 97%, Missing); heart muscle: 96.2733% (minimum 99%, Missing); hippocampal formation: 95.6790% (minimum 99%, Missing); hypothalamus: 96.8750% (minimum 99%, Missing); kidney: 97.4843% (minimum 99%, Missing); liver: 96.8750% (minimum 99%, Missing); lung: 98.1013% (minimum 99%, Missing); lymph node: 92.8144% (minimum 97%, Missing); midbrain: 97.4843% (minimum 99%, Missing); pancreas: 98.7261% (minimum 99%, Missing); pituitary gland: 97.4843% (minimum 99%, Missing); rectum: 95.0920% (minimum 97%, Missing); retina: 94.5122% (minimum 99%, Missing); skeletal muscle: 96.2733% (minimum 99%, Missing); small intestine: 95.0920% (minimum 99%, Missing); smooth muscle: 98.7261% (minimum 99%, Missing); spinal cord: 98.7261% (minimum 99%, Missing); stomach: 96.8750% (minimum 97%, Missing); thymus: 92.2619% (minimum 95%, Missing)",-0.027381,-0.0528402,-0.272407,0,80,unavailable,6.1,1.4,1.3,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127423,AUNIP,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 71.7593% (minimum 75%, Missing)",0.272619,0.21716,-0.0324074,0,80,unavailable,6.1,1.4,1.3,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127423,AUNIP,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 71.7593% (minimum 75%, Missing)",0.272619,0.21716,-0.0324074,0,80,unavailable,6.1,1.4,1.3,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127423,AUNIP,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 71.7593% (minimum 75%, Missing)",0.272619,0.21716,-0.0324074,0,80,unavailable,6.1,1.4,1.3,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127423,AUNIP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 71.7593% (minimum 75%, Baseline (adaptation disabled))",0.272619,0.21716,-0.0324074,0,80,unavailable,6.1,1.4,1.3,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127423,AUNIP,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.6253% (minimum 95%, Missing); adrenal gland: 43.6139% (minimum 99%, Missing); amygdala: 30.0650% (minimum 99%, Missing); basal ganglia: 34.7801% (minimum 99%, Missing); bone marrow: 60.6458% (minimum 99%, Missing); cerebellum: 56.0112% (minimum 99%, Missing); cerebral cortex: 36.1178% (minimum 99%, Missing); choroid plexus: 38.6495% (minimum 99%, Missing); colon: 40.4169% (minimum 97%, Missing); duodenum: 50.9322% (minimum 99%, Missing); esophagus: 46.3377% (minimum 97%, Missing); heart muscle: 17.2552% (minimum 99%, Missing); hippocampal formation: 36.2923% (minimum 99%, Missing); hypothalamus: 41.8524% (minimum 99%, Missing); kidney: 37.3989% (minimum 99%, Missing); liver: 31.1238% (minimum 99%, Missing); lung: 56.0112% (minimum 99%, Missing); lymph node: 69.1600% (minimum 97%, Missing); midbrain: 31.8158% (minimum 99%, Missing); pancreas: 55.6481% (minimum 99%, Missing); parathyroid gland: 57.1293% (minimum 97%, Missing); pituitary gland: 49.6284% (minimum 99%, Missing); rectum: 73.2034% (minimum 97%, Missing); retina: 81.8801% (minimum 99%, Missing); salivary gland: 53.4698% (minimum 97%, Missing); skeletal muscle: 16.6344% (minimum 99%, Missing); skin: 55.1376% (minimum 95%, Missing); small intestine: 49.7105% (minimum 99%, Missing); smooth muscle: 73.5618% (minimum 99%, Missing); spinal cord: 40.3898% (minimum 99%, Missing); spleen: 50.2508% (minimum 95%, Missing); stomach: 44.5185% (minimum 97%, Missing); thymus: 71.9760% (minimum 95%, Missing); thyroid gland: 54.0954% (minimum 95%, Missing); tongue: 36.2923% (minimum 97%, Missing); urinary bladder: 50.5042% (minimum 97%, Missing)",-0.483747,-0.607077,-0.823656,0,80,unavailable,301.2,105.5,68.8,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 2); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 2); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 2); esophagus: 69.6 nTPM (protected, limit 2); adipose tissue: 68.8 nTPM (manageable, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); spleen: 59.5 nTPM (manageable, limit 5); urinary bladder: 58.9 nTPM (protected, limit 2); duodenum: 57.9 nTPM (vital, limit 1); salivary gland: 52.3 nTPM (protected, limit 2); thyroid gland: 51 nTPM (manageable, limit 5); skin: 48.9 nTPM (manageable, limit 5); pancreas: 47.9 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 2); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 2); thymus: 23.4 nTPM (manageable, limit 5); rectum: 22 nTPM (protected, limit 2); smooth muscle: 21.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127540,UQCR11,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.6253% (minimum 65%, Missing); adrenal gland: 43.6139% (minimum 75%, Missing); amygdala: 30.0650% (minimum 75%, Missing); basal ganglia: 34.7801% (minimum 75%, Missing); bone marrow: 60.6458% (minimum 75%, Missing); cerebellum: 56.0112% (minimum 75%, Missing); cerebral cortex: 36.1178% (minimum 75%, Missing); choroid plexus: 38.6495% (minimum 75%, Missing); colon: 40.4169% (minimum 70%, Missing); duodenum: 50.9322% (minimum 75%, Missing); esophagus: 46.3377% (minimum 70%, Missing); heart muscle: 17.2552% (minimum 75%, Missing); hippocampal formation: 36.2923% (minimum 75%, Missing); hypothalamus: 41.8524% (minimum 75%, Missing); kidney: 37.3989% (minimum 75%, Missing); liver: 31.1238% (minimum 75%, Missing); lung: 56.0112% (minimum 75%, Missing); lymph node: 69.1600% (minimum 70%, Missing); midbrain: 31.8158% (minimum 75%, Missing); pancreas: 55.6481% (minimum 75%, Missing); parathyroid gland: 57.1293% (minimum 70%, Missing); pituitary gland: 49.6284% (minimum 75%, Missing); salivary gland: 53.4698% (minimum 70%, Missing); skeletal muscle: 16.6344% (minimum 75%, Missing); skin: 55.1376% (minimum 65%, Missing); small intestine: 49.7105% (minimum 75%, Missing); smooth muscle: 73.5618% (minimum 75%, Missing); spinal cord: 40.3898% (minimum 75%, Missing); spleen: 50.2508% (minimum 65%, Missing); stomach: 44.5185% (minimum 70%, Missing); thyroid gland: 54.0954% (minimum 65%, Missing); tongue: 36.2923% (minimum 70%, Missing); urinary bladder: 50.5042% (minimum 70%, Missing)",-0.183747,-0.337077,-0.583656,0,80,unavailable,301.2,105.5,68.8,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 2); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 2); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 2); esophagus: 69.6 nTPM (protected, limit 2); adipose tissue: 68.8 nTPM (manageable, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); spleen: 59.5 nTPM (manageable, limit 5); urinary bladder: 58.9 nTPM (protected, limit 2); duodenum: 57.9 nTPM (vital, limit 1); salivary gland: 52.3 nTPM (protected, limit 2); thyroid gland: 51 nTPM (manageable, limit 5); skin: 48.9 nTPM (manageable, limit 5); pancreas: 47.9 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 2); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 2); thymus: 23.4 nTPM (manageable, limit 5); rectum: 22 nTPM (protected, limit 2); smooth muscle: 21.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127540,UQCR11,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.6253% (minimum 65%, Missing); adrenal gland: 43.6139% (minimum 75%, Missing); amygdala: 30.0650% (minimum 75%, Missing); basal ganglia: 34.7801% (minimum 75%, Missing); bone marrow: 60.6458% (minimum 75%, Missing); cerebellum: 56.0112% (minimum 75%, Missing); cerebral cortex: 36.1178% (minimum 75%, Missing); choroid plexus: 38.6495% (minimum 75%, Missing); colon: 40.4169% (minimum 70%, Missing); duodenum: 50.9322% (minimum 75%, Missing); esophagus: 46.3377% (minimum 70%, Missing); heart muscle: 17.2552% (minimum 75%, Missing); hippocampal formation: 36.2923% (minimum 75%, Missing); hypothalamus: 41.8524% (minimum 75%, Missing); kidney: 37.3989% (minimum 75%, Missing); liver: 31.1238% (minimum 75%, Missing); lung: 56.0112% (minimum 75%, Missing); lymph node: 69.1600% (minimum 70%, Missing); midbrain: 31.8158% (minimum 75%, Missing); pancreas: 55.6481% (minimum 75%, Missing); parathyroid gland: 57.1293% (minimum 70%, Missing); pituitary gland: 49.6284% (minimum 75%, Missing); salivary gland: 53.4698% (minimum 70%, Missing); skeletal muscle: 16.6344% (minimum 75%, Missing); skin: 55.1376% (minimum 65%, Missing); small intestine: 49.7105% (minimum 75%, Missing); smooth muscle: 73.5618% (minimum 75%, Missing); spinal cord: 40.3898% (minimum 75%, Missing); spleen: 50.2508% (minimum 65%, Missing); stomach: 44.5185% (minimum 70%, Missing); thyroid gland: 54.0954% (minimum 65%, Missing); tongue: 36.2923% (minimum 70%, Missing); urinary bladder: 50.5042% (minimum 70%, Missing)",-0.183747,-0.337077,-0.583656,0,80,unavailable,301.2,105.5,68.8,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 3); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 3); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 3); esophagus: 69.6 nTPM (protected, limit 3); adipose tissue: 68.8 nTPM (manageable, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); spleen: 59.5 nTPM (manageable, limit 5); urinary bladder: 58.9 nTPM (protected, limit 3); duodenum: 57.9 nTPM (vital, limit 1); salivary gland: 52.3 nTPM (protected, limit 3); thyroid gland: 51 nTPM (manageable, limit 5); skin: 48.9 nTPM (manageable, limit 5); pancreas: 47.9 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 3); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 3); thymus: 23.4 nTPM (manageable, limit 5); rectum: 22 nTPM (protected, limit 3); smooth muscle: 21.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127540,UQCR11,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.6253% (minimum 65%, Missing); adrenal gland: 43.6139% (minimum 75%, Missing); amygdala: 30.0650% (minimum 75%, Missing); basal ganglia: 34.7801% (minimum 75%, Missing); bone marrow: 60.6458% (minimum 75%, Missing); cerebellum: 56.0112% (minimum 75%, Missing); cerebral cortex: 36.1178% (minimum 75%, Missing); choroid plexus: 38.6495% (minimum 75%, Missing); colon: 40.4169% (minimum 70%, Missing); duodenum: 50.9322% (minimum 75%, Missing); esophagus: 46.3377% (minimum 70%, Missing); heart muscle: 17.2552% (minimum 75%, Missing); hippocampal formation: 36.2923% (minimum 75%, Missing); hypothalamus: 41.8524% (minimum 75%, Missing); kidney: 37.3989% (minimum 75%, Missing); liver: 31.1238% (minimum 75%, Missing); lung: 56.0112% (minimum 75%, Missing); lymph node: 69.1600% (minimum 70%, Missing); midbrain: 31.8158% (minimum 75%, Missing); pancreas: 55.6481% (minimum 75%, Missing); parathyroid gland: 57.1293% (minimum 70%, Missing); pituitary gland: 49.6284% (minimum 75%, Missing); salivary gland: 53.4698% (minimum 70%, Missing); skeletal muscle: 16.6344% (minimum 75%, Missing); skin: 55.1376% (minimum 65%, Missing); small intestine: 49.7105% (minimum 75%, Missing); smooth muscle: 73.5618% (minimum 75%, Missing); spinal cord: 40.3898% (minimum 75%, Missing); spleen: 50.2508% (minimum 65%, Missing); stomach: 44.5185% (minimum 70%, Missing); thyroid gland: 54.0954% (minimum 65%, Missing); tongue: 36.2923% (minimum 70%, Missing); urinary bladder: 50.5042% (minimum 70%, Missing)",-0.183747,-0.337077,-0.583656,0,80,unavailable,301.2,105.5,68.8,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 3); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 3); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 3); esophagus: 69.6 nTPM (protected, limit 3); adipose tissue: 68.8 nTPM (manageable, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); spleen: 59.5 nTPM (manageable, limit 5); urinary bladder: 58.9 nTPM (protected, limit 3); duodenum: 57.9 nTPM (vital, limit 1); salivary gland: 52.3 nTPM (protected, limit 3); thyroid gland: 51 nTPM (manageable, limit 5); skin: 48.9 nTPM (manageable, limit 5); pancreas: 47.9 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 3); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 3); thymus: 23.4 nTPM (manageable, limit 5); rectum: 22 nTPM (protected, limit 3); smooth muscle: 21.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127540,UQCR11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.6253% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 43.6139% (minimum 75%, Baseline (adaptation disabled)); amygdala: 30.0650% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 34.7801% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 60.6458% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.0112% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 36.1178% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 38.6495% (minimum 75%, Baseline (adaptation disabled)); colon: 40.4169% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.9322% (minimum 75%, Baseline (adaptation disabled)); esophagus: 46.3377% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 17.2552% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 36.2923% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 41.8524% (minimum 75%, Baseline (adaptation disabled)); kidney: 37.3989% (minimum 75%, Baseline (adaptation disabled)); liver: 31.1238% (minimum 75%, Baseline (adaptation disabled)); lung: 56.0112% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.1600% (minimum 70%, Baseline (adaptation disabled)); midbrain: 31.8158% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.6481% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.1293% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 49.6284% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.4698% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 16.6344% (minimum 75%, Baseline (adaptation disabled)); skin: 55.1376% (minimum 65%, Baseline (adaptation disabled)); small intestine: 49.7105% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.5618% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 40.3898% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.2508% (minimum 65%, Baseline (adaptation disabled)); stomach: 44.5185% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 54.0954% (minimum 65%, Baseline (adaptation disabled)); tongue: 36.2923% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 50.5042% (minimum 70%, Baseline (adaptation disabled))",-0.183747,-0.337077,-0.583656,0,80,unavailable,301.2,105.5,68.8,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 3); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 3); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 3); esophagus: 69.6 nTPM (protected, limit 3); adipose tissue: 68.8 nTPM (manageable, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); spleen: 59.5 nTPM (manageable, limit 5); urinary bladder: 58.9 nTPM (protected, limit 3); duodenum: 57.9 nTPM (vital, limit 1); salivary gland: 52.3 nTPM (protected, limit 3); thyroid gland: 51 nTPM (manageable, limit 5); skin: 48.9 nTPM (manageable, limit 5); pancreas: 47.9 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 3); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 3); thymus: 23.4 nTPM (manageable, limit 5); rectum: 22 nTPM (protected, limit 3); smooth muscle: 21.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127540,UQCR11,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2238% (minimum 99%, Missing); amygdala: 98.0496% (minimum 99%, Missing); basal ganglia: 98.3986% (minimum 99%, Missing); bone marrow: 66.9492% (minimum 99%, Missing); cerebellum: 93.5702% (minimum 99%, Missing); cerebral cortex: 97.7032% (minimum 99%, Missing); colon: 93.5702% (minimum 97%, Missing); duodenum: 95.3448% (minimum 99%, Missing); esophagus: 83.1579% (minimum 97%, Missing); heart muscle: 98.5740% (minimum 99%, Missing); hippocampal formation: 97.8761% (minimum 99%, Missing); hypothalamus: 98.0496% (minimum 99%, Missing); kidney: 98.3986% (minimum 99%, Missing); liver: 97.1880% (minimum 99%, Missing); lung: 96.6783% (minimum 99%, Missing); lymph node: 87.6387% (minimum 97%, Missing); midbrain: 97.8761% (minimum 99%, Missing); pancreas: 97.0175% (minimum 99%, Missing); pituitary gland: 98.2238% (minimum 99%, Missing); retina: 76.5928% (minimum 99%, Missing); salivary gland: 96.6783% (minimum 97%, Missing); skeletal muscle: 96.0069% (minimum 99%, Missing); skin: 92.7852% (minimum 95%, Missing); small intestine: 93.4122% (minimum 99%, Missing); smooth muscle: 98.3986% (minimum 99%, Missing); spinal cord: 96.8476% (minimum 99%, Missing); spleen: 91.1038% (minimum 95%, Missing); stomach: 94.5299% (minimum 97%, Missing); thymus: 85.6037% (minimum 95%, Missing)",-0.0939628,-0.138421,-0.320508,0,80,unavailable,27.3,11.2,9.3,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 2); thymus: 9.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127564,PKMYT1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 66.9492% (minimum 75%, Missing)",0.206037,0.131579,-0.0805085,0,80,unavailable,27.3,11.2,9.3,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 2); thymus: 9.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127564,PKMYT1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 66.9492% (minimum 75%, Missing)",0.206037,0.131579,-0.0805085,0,80,unavailable,27.3,11.2,9.3,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 3); thymus: 9.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127564,PKMYT1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 66.9492% (minimum 75%, Missing)",0.206037,0.131579,-0.0805085,0,80,unavailable,27.3,11.2,9.3,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 3); thymus: 9.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127564,PKMYT1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 66.9492% (minimum 75%, Baseline (adaptation disabled))",0.206037,0.131579,-0.0805085,0,80,unavailable,27.3,11.2,9.3,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 3); thymus: 9.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127564,PKMYT1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.0472% (minimum 90%, Approved); adrenal gland: 65.9919% (minimum 99%, Missing); amygdala: 70.5628% (minimum 99%, Missing); basal ganglia: 65.7258% (minimum 99%, Missing); bone marrow: 50.3864% (minimum 99%, Missing); cerebellum: 64.5545% (minimum 98%, Approved); cerebral cortex: 60.2588% (minimum 99%, Missing); choroid plexus: 75.9907% (minimum 99%, Missing); colon: 64.6825% (minimum 97%, Missing); duodenum: 65.7258% (minimum 99%, Missing); esophagus: 64.5545% (minimum 95%, Approved); heart muscle: 71.1790% (minimum 98%, Approved); hippocampal formation: 71.0240% (minimum 99%, Missing); hypothalamus: 73.9229% (minimum 99%, Missing); kidney: 64.9402% (minimum 99%, Missing); liver: 66.9405% (minimum 98%, Approved); lung: 67.4948% (minimum 99%, Missing); lymph node: 59.8165% (minimum 95%, Approved); midbrain: 75.9907% (minimum 99%, Missing); pancreas: 70.4104% (minimum 98%, Approved); parathyroid gland: 60.1476% (minimum 97%, Missing); pituitary gland: 75.6381% (minimum 99%, Missing); rectum: 64.5545% (minimum 97%, Missing); retina: 55.8219% (minimum 99%, Missing); salivary gland: 71.3348% (minimum 95%, Approved); skeletal muscle: 61.5094% (minimum 98%, Approved); skin: 65.8586% (minimum 95%, Missing); small intestine: 64.0472% (minimum 99%, Missing); smooth muscle: 68.3438% (minimum 98%, Approved); spinal cord: 78.5542% (minimum 99%, Missing); spleen: 62.9344% (minimum 95%, Missing); stomach: 66.1258% (minimum 97%, Missing); thymus: 56.9930% (minimum 95%, Missing); thyroid gland: 65.8586% (minimum 90%, Approved); tongue: 68.9218% (minimum 97%, Missing); urinary bladder: 64.8111% (minimum 97%, Missing)",-0.38007,-0.368524,-0.486136,0,3,partial,32.1,21.9,24.6,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); thymus: 24.6 nTPM (manageable, limit 5); lymph node: 21.9 nTPM (protected, limit 4); parathyroid gland: 21.6 nTPM (protected, limit 2); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 2); spleen: 19.2 nTPM (manageable, limit 5); adipose tissue: 18.3 nTPM (manageable, limit 10); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 2); esophagus: 17.9 nTPM (protected, limit 4); rectum: 17.9 nTPM (protected, limit 2); colon: 17.8 nTPM (protected, limit 2); urinary bladder: 17.7 nTPM (protected, limit 2); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); thyroid gland: 16.9 nTPM (manageable, limit 10); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 2); liver: 16.1 nTPM (vital, limit 2); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 2); tongue: 14.7 nTPM (protected, limit 2); pancreas: 13.7 nTPM (vital, limit 2); amygdala: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 2); salivary gland: 13.1 nTPM (protected, limit 4); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127870,RNF6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.9919% (minimum 75%, Missing); amygdala: 70.5628% (minimum 75%, Missing); basal ganglia: 65.7258% (minimum 75%, Missing); bone marrow: 50.3864% (minimum 75%, Missing); cerebellum: 64.5545% (minimum 70%, Approved); cerebral cortex: 60.2588% (minimum 75%, Missing); colon: 64.6825% (minimum 70%, Missing); duodenum: 65.7258% (minimum 75%, Missing); esophagus: 64.5545% (minimum 65%, Approved); hippocampal formation: 71.0240% (minimum 75%, Missing); hypothalamus: 73.9229% (minimum 75%, Missing); kidney: 64.9402% (minimum 75%, Missing); liver: 66.9405% (minimum 70%, Approved); lung: 67.4948% (minimum 75%, Missing); lymph node: 59.8165% (minimum 65%, Approved); parathyroid gland: 60.1476% (minimum 70%, Missing); rectum: 64.5545% (minimum 70%, Missing); retina: 55.8219% (minimum 75%, Missing); skeletal muscle: 61.5094% (minimum 70%, Approved); small intestine: 64.0472% (minimum 75%, Missing); smooth muscle: 68.3438% (minimum 70%, Approved); spleen: 62.9344% (minimum 65%, Missing); stomach: 66.1258% (minimum 70%, Missing); thymus: 56.9930% (minimum 65%, Missing); tongue: 68.9218% (minimum 70%, Missing); urinary bladder: 64.8111% (minimum 70%, Missing)",-0.0800699,-0.098524,-0.246136,0,3,partial,32.1,21.9,24.6,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); thymus: 24.6 nTPM (manageable, limit 5); lymph node: 21.9 nTPM (protected, limit 4); parathyroid gland: 21.6 nTPM (protected, limit 2); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 2); spleen: 19.2 nTPM (manageable, limit 5); adipose tissue: 18.3 nTPM (manageable, limit 10); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 2); esophagus: 17.9 nTPM (protected, limit 4); rectum: 17.9 nTPM (protected, limit 2); colon: 17.8 nTPM (protected, limit 2); urinary bladder: 17.7 nTPM (protected, limit 2); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); thyroid gland: 16.9 nTPM (manageable, limit 10); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 2); liver: 16.1 nTPM (vital, limit 2); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 2); tongue: 14.7 nTPM (protected, limit 2); pancreas: 13.7 nTPM (vital, limit 2); amygdala: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 2); salivary gland: 13.1 nTPM (protected, limit 4); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127870,RNF6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.9919% (minimum 75%, Missing); amygdala: 70.5628% (minimum 75%, Missing); basal ganglia: 65.7258% (minimum 75%, Missing); bone marrow: 50.3864% (minimum 75%, Missing); cerebellum: 64.5545% (minimum 70%, Approved); cerebral cortex: 60.2588% (minimum 75%, Missing); colon: 64.6825% (minimum 70%, Missing); duodenum: 65.7258% (minimum 75%, Missing); esophagus: 64.5545% (minimum 65%, Approved); hippocampal formation: 71.0240% (minimum 75%, Missing); hypothalamus: 73.9229% (minimum 75%, Missing); kidney: 64.9402% (minimum 75%, Missing); liver: 66.9405% (minimum 70%, Approved); lung: 67.4948% (minimum 75%, Missing); lymph node: 59.8165% (minimum 65%, Approved); parathyroid gland: 60.1476% (minimum 70%, Missing); rectum: 64.5545% (minimum 70%, Missing); retina: 55.8219% (minimum 75%, Missing); skeletal muscle: 61.5094% (minimum 70%, Approved); small intestine: 64.0472% (minimum 75%, Missing); smooth muscle: 68.3438% (minimum 70%, Approved); spleen: 62.9344% (minimum 65%, Missing); stomach: 66.1258% (minimum 70%, Missing); thymus: 56.9930% (minimum 65%, Missing); tongue: 68.9218% (minimum 70%, Missing); urinary bladder: 64.8111% (minimum 70%, Missing)",-0.0800699,-0.098524,-0.246136,0,3,partial,32.1,21.9,24.6,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); thymus: 24.6 nTPM (manageable, limit 5); lymph node: 21.9 nTPM (protected, limit 4); parathyroid gland: 21.6 nTPM (protected, limit 3); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 2); spleen: 19.2 nTPM (manageable, limit 5); adipose tissue: 18.3 nTPM (manageable, limit 10); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 2); esophagus: 17.9 nTPM (protected, limit 4); rectum: 17.9 nTPM (protected, limit 3); colon: 17.8 nTPM (protected, limit 3); urinary bladder: 17.7 nTPM (protected, limit 3); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); thyroid gland: 16.9 nTPM (manageable, limit 10); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 3); liver: 16.1 nTPM (vital, limit 2); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 2); tongue: 14.7 nTPM (protected, limit 3); pancreas: 13.7 nTPM (vital, limit 2); amygdala: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 2); salivary gland: 13.1 nTPM (protected, limit 4); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127870,RNF6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.9919% (minimum 75%, Missing); amygdala: 70.5628% (minimum 75%, Missing); basal ganglia: 65.7258% (minimum 75%, Missing); bone marrow: 50.3864% (minimum 75%, Missing); cerebellum: 64.5545% (minimum 70%, Approved); cerebral cortex: 60.2588% (minimum 75%, Missing); colon: 64.6825% (minimum 70%, Missing); duodenum: 65.7258% (minimum 75%, Missing); esophagus: 64.5545% (minimum 65%, Approved); hippocampal formation: 71.0240% (minimum 75%, Missing); hypothalamus: 73.9229% (minimum 75%, Missing); kidney: 64.9402% (minimum 75%, Missing); liver: 66.9405% (minimum 70%, Approved); lung: 67.4948% (minimum 75%, Missing); lymph node: 59.8165% (minimum 65%, Approved); parathyroid gland: 60.1476% (minimum 70%, Missing); rectum: 64.5545% (minimum 70%, Missing); retina: 55.8219% (minimum 75%, Missing); skeletal muscle: 61.5094% (minimum 70%, Approved); small intestine: 64.0472% (minimum 75%, Missing); smooth muscle: 68.3438% (minimum 70%, Approved); spleen: 62.9344% (minimum 65%, Missing); stomach: 66.1258% (minimum 70%, Missing); thymus: 56.9930% (minimum 65%, Missing); tongue: 68.9218% (minimum 70%, Missing); urinary bladder: 64.8111% (minimum 70%, Missing)",-0.0800699,-0.098524,-0.246136,0,3,partial,32.1,21.9,24.6,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); thymus: 24.6 nTPM (manageable, limit 5); lymph node: 21.9 nTPM (protected, limit 4); parathyroid gland: 21.6 nTPM (protected, limit 3); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 2); spleen: 19.2 nTPM (manageable, limit 5); adipose tissue: 18.3 nTPM (manageable, limit 10); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 2); esophagus: 17.9 nTPM (protected, limit 4); rectum: 17.9 nTPM (protected, limit 3); colon: 17.8 nTPM (protected, limit 3); urinary bladder: 17.7 nTPM (protected, limit 3); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); thyroid gland: 16.9 nTPM (manageable, limit 10); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 3); liver: 16.1 nTPM (vital, limit 2); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 2); tongue: 14.7 nTPM (protected, limit 3); pancreas: 13.7 nTPM (vital, limit 2); amygdala: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 2); salivary gland: 13.1 nTPM (protected, limit 4); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127870,RNF6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.0472% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 65.9919% (minimum 75%, Baseline (adaptation disabled)); amygdala: 70.5628% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.7258% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 50.3864% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.5545% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.2588% (minimum 75%, Baseline (adaptation disabled)); colon: 64.6825% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.7258% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.5545% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 71.1790% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.0240% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.9229% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.9402% (minimum 75%, Baseline (adaptation disabled)); liver: 66.9405% (minimum 75%, Baseline (adaptation disabled)); lung: 67.4948% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.8165% (minimum 70%, Baseline (adaptation disabled)); pancreas: 70.4104% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.1476% (minimum 70%, Baseline (adaptation disabled)); rectum: 64.5545% (minimum 70%, Baseline (adaptation disabled)); retina: 55.8219% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 61.5094% (minimum 75%, Baseline (adaptation disabled)); small intestine: 64.0472% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.3438% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.9344% (minimum 65%, Baseline (adaptation disabled)); stomach: 66.1258% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.9930% (minimum 65%, Baseline (adaptation disabled)); tongue: 68.9218% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 64.8111% (minimum 70%, Baseline (adaptation disabled))",-0.0800699,-0.101835,-0.246136,0,3,partial,32.1,21.9,24.6,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); thymus: 24.6 nTPM (manageable, limit 5); lymph node: 21.9 nTPM (protected, limit 3); parathyroid gland: 21.6 nTPM (protected, limit 3); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 1); spleen: 19.2 nTPM (manageable, limit 5); adipose tissue: 18.3 nTPM (manageable, limit 5); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 3); rectum: 17.9 nTPM (protected, limit 3); colon: 17.8 nTPM (protected, limit 3); urinary bladder: 17.7 nTPM (protected, limit 3); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); thyroid gland: 16.9 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 3); liver: 16.1 nTPM (vital, limit 1); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 3); pancreas: 13.7 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 3); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127870,RNF6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 20.1439% (minimum 99%, Missing); heart muscle: 93.3333% (minimum 95%, Enhanced); kidney: 90.3226% (minimum 95%, Enhanced); retina: 0.1517% (minimum 99%, Missing); tongue: 96.5517% (minimum 97%, Missing)",0.0155172,-0.00448276,-0.988483,0,0,routine_complete,1842.8,0.4,0.1,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127928,GNGT1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 20.1439% (minimum 75%, Missing); retina: 0.1517% (minimum 75%, Missing)",0.315517,0.265517,-0.748483,0,0,routine_complete,1842.8,0.4,0.1,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127928,GNGT1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 20.1439% (minimum 75%, Missing); retina: 0.1517% (minimum 75%, Missing)",0.315517,0.265517,-0.748483,0,0,routine_complete,1842.8,0.4,0.1,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127928,GNGT1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 20.1439% (minimum 75%, Missing); retina: 0.1517% (minimum 75%, Missing)",0.315517,0.265517,-0.748483,0,0,routine_complete,1842.8,0.4,0.1,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127928,GNGT1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 20.1439% (minimum 75%, Baseline (adaptation disabled)); retina: 0.1517% (minimum 75%, Baseline (adaptation disabled))",0.315517,0.175,-0.748483,0,0,routine_complete,1842.8,0.4,0.1,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127928,GNGT1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0230% (minimum 95%, Uncertain); adrenal gland: 53.1073% (minimum 99%, Missing); amygdala: 48.9583% (minimum 99%, Missing); basal ganglia: 44.1315% (minimum 99%, Missing); bone marrow: 40.5172% (minimum 99%, Missing); cerebellum: 40.1709% (minimum 99%, Missing); cerebral cortex: 41.9643% (minimum 99%, Missing); choroid plexus: 67.6259% (minimum 99%, Missing); colon: 54.6512% (minimum 97%, Missing); duodenum: 64.3836% (minimum 99%, Missing); esophagus: 55.9524% (minimum 97%, Missing); heart muscle: 49.2147% (minimum 99%, Missing); hippocampal formation: 43.1193% (minimum 99%, Missing); hypothalamus: 45.8537% (minimum 99%, Missing); kidney: 56.6265% (minimum 99%, Missing); liver: 51.6484% (minimum 99%, Missing); lung: 60.2564% (minimum 99%, Missing); lymph node: 53.4091% (minimum 97%, Missing); midbrain: 42.9224% (minimum 99%, Missing); pancreas: 53.4091% (minimum 99%, Missing); parathyroid gland: 67.6259% (minimum 97%, Missing); pituitary gland: 56.2874% (minimum 99%, Missing); rectum: 67.6259% (minimum 97%, Missing); retina: 59.8726% (minimum 99%, Missing); salivary gland: 53.7143% (minimum 97%, Missing); skeletal muscle: 41.9643% (minimum 99%, Missing); skin: 54.6512% (minimum 95%, Missing); small intestine: 51.9337% (minimum 99%, Missing); smooth muscle: 72.8682% (minimum 99%, Missing); spinal cord: 40.0000% (minimum 99%, Missing); spleen: 45.8537% (minimum 95%, Missing); stomach: 54.9708% (minimum 97%, Missing); thymus: 59.4937% (minimum 95%, Missing); thyroid gland: 53.7143% (minimum 95%, Missing); tongue: 58.3851% (minimum 97%, Missing); urinary bladder: 56.9697% (minimum 97%, Missing)",-0.491463,-0.435909,-0.59,0,1,partial,14.1,8.2,11.1,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); spleen: 11.1 nTPM (manageable, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); pancreas: 8.2 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 2); thyroid gland: 8.1 nTPM (manageable, limit 5); salivary gland: 8.1 nTPM (protected, limit 2); adipose tissue: 8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); colon: 7.8 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 2); tongue: 6.7 nTPM (protected, limit 2); thymus: 6.4 nTPM (manageable, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127993,RBM48,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0230% (minimum 65%, Uncertain); adrenal gland: 53.1073% (minimum 75%, Missing); amygdala: 48.9583% (minimum 75%, Missing); basal ganglia: 44.1315% (minimum 75%, Missing); bone marrow: 40.5172% (minimum 75%, Missing); cerebellum: 40.1709% (minimum 75%, Missing); cerebral cortex: 41.9643% (minimum 75%, Missing); choroid plexus: 67.6259% (minimum 75%, Missing); colon: 54.6512% (minimum 70%, Missing); duodenum: 64.3836% (minimum 75%, Missing); esophagus: 55.9524% (minimum 70%, Missing); heart muscle: 49.2147% (minimum 75%, Missing); hippocampal formation: 43.1193% (minimum 75%, Missing); hypothalamus: 45.8537% (minimum 75%, Missing); kidney: 56.6265% (minimum 75%, Missing); liver: 51.6484% (minimum 75%, Missing); lung: 60.2564% (minimum 75%, Missing); lymph node: 53.4091% (minimum 70%, Missing); midbrain: 42.9224% (minimum 75%, Missing); pancreas: 53.4091% (minimum 75%, Missing); parathyroid gland: 67.6259% (minimum 70%, Missing); pituitary gland: 56.2874% (minimum 75%, Missing); rectum: 67.6259% (minimum 70%, Missing); retina: 59.8726% (minimum 75%, Missing); salivary gland: 53.7143% (minimum 70%, Missing); skeletal muscle: 41.9643% (minimum 75%, Missing); skin: 54.6512% (minimum 65%, Missing); small intestine: 51.9337% (minimum 75%, Missing); smooth muscle: 72.8682% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing); spleen: 45.8537% (minimum 65%, Missing); stomach: 54.9708% (minimum 70%, Missing); thymus: 59.4937% (minimum 65%, Missing); thyroid gland: 53.7143% (minimum 65%, Missing); tongue: 58.3851% (minimum 70%, Missing); urinary bladder: 56.9697% (minimum 70%, Missing)",-0.191463,-0.165909,-0.35,0,1,partial,14.1,8.2,11.1,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); spleen: 11.1 nTPM (manageable, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); pancreas: 8.2 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 2); thyroid gland: 8.1 nTPM (manageable, limit 5); salivary gland: 8.1 nTPM (protected, limit 2); adipose tissue: 8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); colon: 7.8 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 2); tongue: 6.7 nTPM (protected, limit 2); thymus: 6.4 nTPM (manageable, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127993,RBM48,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0230% (minimum 65%, Uncertain); adrenal gland: 53.1073% (minimum 75%, Missing); amygdala: 48.9583% (minimum 75%, Missing); basal ganglia: 44.1315% (minimum 75%, Missing); bone marrow: 40.5172% (minimum 75%, Missing); cerebellum: 40.1709% (minimum 75%, Missing); cerebral cortex: 41.9643% (minimum 75%, Missing); choroid plexus: 67.6259% (minimum 75%, Missing); colon: 54.6512% (minimum 70%, Missing); duodenum: 64.3836% (minimum 75%, Missing); esophagus: 55.9524% (minimum 70%, Missing); heart muscle: 49.2147% (minimum 75%, Missing); hippocampal formation: 43.1193% (minimum 75%, Missing); hypothalamus: 45.8537% (minimum 75%, Missing); kidney: 56.6265% (minimum 75%, Missing); liver: 51.6484% (minimum 75%, Missing); lung: 60.2564% (minimum 75%, Missing); lymph node: 53.4091% (minimum 70%, Missing); midbrain: 42.9224% (minimum 75%, Missing); pancreas: 53.4091% (minimum 75%, Missing); parathyroid gland: 67.6259% (minimum 70%, Missing); pituitary gland: 56.2874% (minimum 75%, Missing); rectum: 67.6259% (minimum 70%, Missing); retina: 59.8726% (minimum 75%, Missing); salivary gland: 53.7143% (minimum 70%, Missing); skeletal muscle: 41.9643% (minimum 75%, Missing); skin: 54.6512% (minimum 65%, Missing); small intestine: 51.9337% (minimum 75%, Missing); smooth muscle: 72.8682% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing); spleen: 45.8537% (minimum 65%, Missing); stomach: 54.9708% (minimum 70%, Missing); thymus: 59.4937% (minimum 65%, Missing); thyroid gland: 53.7143% (minimum 65%, Missing); tongue: 58.3851% (minimum 70%, Missing); urinary bladder: 56.9697% (minimum 70%, Missing)",-0.191463,-0.165909,-0.35,0,1,partial,14.1,8.2,11.1,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); spleen: 11.1 nTPM (manageable, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); pancreas: 8.2 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 3); thyroid gland: 8.1 nTPM (manageable, limit 5); salivary gland: 8.1 nTPM (protected, limit 3); adipose tissue: 8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); colon: 7.8 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 3); tongue: 6.7 nTPM (protected, limit 3); thymus: 6.4 nTPM (manageable, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3); rectum: 4.5 nTPM (protected, limit 3); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127993,RBM48,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0230% (minimum 65%, Uncertain); adrenal gland: 53.1073% (minimum 75%, Missing); amygdala: 48.9583% (minimum 75%, Missing); basal ganglia: 44.1315% (minimum 75%, Missing); bone marrow: 40.5172% (minimum 75%, Missing); cerebellum: 40.1709% (minimum 75%, Missing); cerebral cortex: 41.9643% (minimum 75%, Missing); choroid plexus: 67.6259% (minimum 75%, Missing); colon: 54.6512% (minimum 70%, Missing); duodenum: 64.3836% (minimum 75%, Missing); esophagus: 55.9524% (minimum 70%, Missing); heart muscle: 49.2147% (minimum 75%, Missing); hippocampal formation: 43.1193% (minimum 75%, Missing); hypothalamus: 45.8537% (minimum 75%, Missing); kidney: 56.6265% (minimum 75%, Missing); liver: 51.6484% (minimum 75%, Missing); lung: 60.2564% (minimum 75%, Missing); lymph node: 53.4091% (minimum 70%, Missing); midbrain: 42.9224% (minimum 75%, Missing); pancreas: 53.4091% (minimum 75%, Missing); parathyroid gland: 67.6259% (minimum 70%, Missing); pituitary gland: 56.2874% (minimum 75%, Missing); rectum: 67.6259% (minimum 70%, Missing); retina: 59.8726% (minimum 75%, Missing); salivary gland: 53.7143% (minimum 70%, Missing); skeletal muscle: 41.9643% (minimum 75%, Missing); skin: 54.6512% (minimum 65%, Missing); small intestine: 51.9337% (minimum 75%, Missing); smooth muscle: 72.8682% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing); spleen: 45.8537% (minimum 65%, Missing); stomach: 54.9708% (minimum 70%, Missing); thymus: 59.4937% (minimum 65%, Missing); thyroid gland: 53.7143% (minimum 65%, Missing); tongue: 58.3851% (minimum 70%, Missing); urinary bladder: 56.9697% (minimum 70%, Missing)",-0.191463,-0.165909,-0.35,0,1,partial,14.1,8.2,11.1,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); spleen: 11.1 nTPM (manageable, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); pancreas: 8.2 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 3); thyroid gland: 8.1 nTPM (manageable, limit 5); salivary gland: 8.1 nTPM (protected, limit 3); adipose tissue: 8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); colon: 7.8 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 3); tongue: 6.7 nTPM (protected, limit 3); thymus: 6.4 nTPM (manageable, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3); rectum: 4.5 nTPM (protected, limit 3); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127993,RBM48,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0230% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 53.1073% (minimum 75%, Baseline (adaptation disabled)); amygdala: 48.9583% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 44.1315% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 40.5172% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 40.1709% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 41.9643% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.6259% (minimum 75%, Baseline (adaptation disabled)); colon: 54.6512% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.3836% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.9524% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 49.2147% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 43.1193% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 45.8537% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.6265% (minimum 75%, Baseline (adaptation disabled)); liver: 51.6484% (minimum 75%, Baseline (adaptation disabled)); lung: 60.2564% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.4091% (minimum 70%, Baseline (adaptation disabled)); midbrain: 42.9224% (minimum 75%, Baseline (adaptation disabled)); pancreas: 53.4091% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 67.6259% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 56.2874% (minimum 75%, Baseline (adaptation disabled)); rectum: 67.6259% (minimum 70%, Baseline (adaptation disabled)); retina: 59.8726% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.7143% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 41.9643% (minimum 75%, Baseline (adaptation disabled)); skin: 54.6512% (minimum 65%, Baseline (adaptation disabled)); small intestine: 51.9337% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.8682% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 40.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 45.8537% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.9708% (minimum 70%, Baseline (adaptation disabled)); thymus: 59.4937% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.7143% (minimum 65%, Baseline (adaptation disabled)); tongue: 58.3851% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.9697% (minimum 70%, Baseline (adaptation disabled))",-0.191463,-0.165909,-0.35,0,1,partial,14.1,8.2,11.1,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); spleen: 11.1 nTPM (manageable, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); pancreas: 8.2 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 3); thyroid gland: 8.1 nTPM (manageable, limit 5); salivary gland: 8.1 nTPM (protected, limit 3); adipose tissue: 8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); colon: 7.8 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 3); tongue: 6.7 nTPM (protected, limit 3); thymus: 6.4 nTPM (manageable, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3); rectum: 4.5 nTPM (protected, limit 3); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000127993,RBM48,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0492589,0.0295708,0.00818826,0,1,partial,13.1,4.6,3.8,"bone marrow: 13.1 nTPM (vital, limit 6); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 6); pituitary gland: 4 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128040,SPINK2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349259,0.299571,0.248188,0,1,partial,13.1,4.6,3.8,"bone marrow: 13.1 nTPM (vital, limit 6); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 6); pituitary gland: 4 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128040,SPINK2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349259,0.299571,0.248188,0,1,partial,13.1,4.6,3.8,"bone marrow: 13.1 nTPM (vital, limit 6); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 6); pituitary gland: 4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128040,SPINK2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349259,0.299571,0.248188,0,1,partial,13.1,4.6,3.8,"bone marrow: 13.1 nTPM (vital, limit 6); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 6); pituitary gland: 4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128040,SPINK2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349259,0.299103,0.24745,0,1,partial,13.1,4.6,3.8,"bone marrow: 13.1 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 3); pituitary gland: 4 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128040,SPINK2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.6757% (minimum 95%, Missing); adrenal gland: 58.7413% (minimum 99%, Missing); amygdala: 71.7949% (minimum 99%, Missing); basal ganglia: 71.1864% (minimum 99%, Missing); bone marrow: 60.4317% (minimum 98%, Approved); cerebellum: 68.8525% (minimum 98%, Approved); cerebral cortex: 60.4317% (minimum 99%, Missing); choroid plexus: 70.5882% (minimum 99%, Missing); colon: 68.8525% (minimum 97%, Missing); duodenum: 68.2927% (minimum 99%, Missing); esophagus: 66.1417% (minimum 97%, Missing); heart muscle: 79.2453% (minimum 99%, Missing); hippocampal formation: 73.6842% (minimum 99%, Missing); hypothalamus: 71.1864% (minimum 99%, Missing); kidney: 59.1549% (minimum 99%, Missing); liver: 58.3333% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 50.6024% (minimum 97%, Missing); midbrain: 70.5882% (minimum 99%, Missing); pancreas: 59.5745% (minimum 99%, Missing); parathyroid gland: 68.8525% (minimum 95%, Approved); pituitary gland: 77.7778% (minimum 99%, Missing); rectum: 64.6154% (minimum 97%, Missing); retina: 66.1417% (minimum 99%, Missing); salivary gland: 60.4317% (minimum 97%, Missing); skeletal muscle: 75.0000% (minimum 99%, Missing); skin: 66.1417% (minimum 90%, Approved); small intestine: 73.0435% (minimum 99%, Missing); smooth muscle: 70.5882% (minimum 98%, Approved); spinal cord: 75.6757% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 70.5882% (minimum 97%, Missing); thymus: 50.9091% (minimum 95%, Missing); thyroid gland: 59.1549% (minimum 90%, Approved); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 56.3758% (minimum 95%, Approved)",-0.440909,-0.463976,-0.406667,0,3,partial,6,8.2,8.1,"lymph node: 8.2 nTPM (protected, limit 2); thymus: 8.1 nTPM (manageable, limit 5); urinary bladder: 6.5 nTPM (protected, limit 4); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); kidney: 5.8 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); bone marrow: 5.5 nTPM (vital, limit 2); cerebral cortex: 5.5 nTPM (vital, limit 1); rectum: 4.6 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); colon: 3.8 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 2); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); skeletal muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128059,PPAT,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 58.7413% (minimum 75%, Missing); amygdala: 71.7949% (minimum 75%, Missing); basal ganglia: 71.1864% (minimum 75%, Missing); bone marrow: 60.4317% (minimum 70%, Approved); cerebellum: 68.8525% (minimum 70%, Approved); cerebral cortex: 60.4317% (minimum 75%, Missing); choroid plexus: 70.5882% (minimum 75%, Missing); colon: 68.8525% (minimum 70%, Missing); duodenum: 68.2927% (minimum 75%, Missing); esophagus: 66.1417% (minimum 70%, Missing); hippocampal formation: 73.6842% (minimum 75%, Missing); hypothalamus: 71.1864% (minimum 75%, Missing); kidney: 59.1549% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lymph node: 50.6024% (minimum 70%, Missing); midbrain: 70.5882% (minimum 75%, Missing); pancreas: 59.5745% (minimum 75%, Missing); rectum: 64.6154% (minimum 70%, Missing); retina: 66.1417% (minimum 75%, Missing); salivary gland: 60.4317% (minimum 70%, Missing); small intestine: 73.0435% (minimum 75%, Missing); thymus: 50.9091% (minimum 65%, Missing); thyroid gland: 59.1549% (minimum 60%, Approved); urinary bladder: 56.3758% (minimum 65%, Approved)",-0.140909,-0.193976,-0.166667,0,3,partial,6,8.2,8.1,"lymph node: 8.2 nTPM (protected, limit 2); thymus: 8.1 nTPM (manageable, limit 5); urinary bladder: 6.5 nTPM (protected, limit 4); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); kidney: 5.8 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); bone marrow: 5.5 nTPM (vital, limit 2); cerebral cortex: 5.5 nTPM (vital, limit 1); rectum: 4.6 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); colon: 3.8 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 2); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); skeletal muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128059,PPAT,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 58.7413% (minimum 75%, Missing); amygdala: 71.7949% (minimum 75%, Missing); basal ganglia: 71.1864% (minimum 75%, Missing); bone marrow: 60.4317% (minimum 70%, Approved); cerebellum: 68.8525% (minimum 70%, Approved); cerebral cortex: 60.4317% (minimum 75%, Missing); choroid plexus: 70.5882% (minimum 75%, Missing); colon: 68.8525% (minimum 70%, Missing); duodenum: 68.2927% (minimum 75%, Missing); esophagus: 66.1417% (minimum 70%, Missing); hippocampal formation: 73.6842% (minimum 75%, Missing); hypothalamus: 71.1864% (minimum 75%, Missing); kidney: 59.1549% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lymph node: 50.6024% (minimum 70%, Missing); midbrain: 70.5882% (minimum 75%, Missing); pancreas: 59.5745% (minimum 75%, Missing); rectum: 64.6154% (minimum 70%, Missing); retina: 66.1417% (minimum 75%, Missing); salivary gland: 60.4317% (minimum 70%, Missing); small intestine: 73.0435% (minimum 75%, Missing); thymus: 50.9091% (minimum 65%, Missing); thyroid gland: 59.1549% (minimum 60%, Approved); urinary bladder: 56.3758% (minimum 65%, Approved)",-0.140909,-0.193976,-0.166667,0,3,partial,6,8.2,8.1,"lymph node: 8.2 nTPM (protected, limit 3); thymus: 8.1 nTPM (manageable, limit 5); urinary bladder: 6.5 nTPM (protected, limit 4); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); kidney: 5.8 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); bone marrow: 5.5 nTPM (vital, limit 2); rectum: 4.6 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); cerebellum: 3.8 nTPM (vital, limit 2); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 2); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128059,PPAT,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 58.7413% (minimum 75%, Missing); amygdala: 71.7949% (minimum 75%, Missing); basal ganglia: 71.1864% (minimum 75%, Missing); bone marrow: 60.4317% (minimum 70%, Approved); cerebellum: 68.8525% (minimum 70%, Approved); cerebral cortex: 60.4317% (minimum 75%, Missing); choroid plexus: 70.5882% (minimum 75%, Missing); colon: 68.8525% (minimum 70%, Missing); duodenum: 68.2927% (minimum 75%, Missing); esophagus: 66.1417% (minimum 70%, Missing); hippocampal formation: 73.6842% (minimum 75%, Missing); hypothalamus: 71.1864% (minimum 75%, Missing); kidney: 59.1549% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lymph node: 50.6024% (minimum 70%, Missing); midbrain: 70.5882% (minimum 75%, Missing); pancreas: 59.5745% (minimum 75%, Missing); rectum: 64.6154% (minimum 70%, Missing); retina: 66.1417% (minimum 75%, Missing); salivary gland: 60.4317% (minimum 70%, Missing); small intestine: 73.0435% (minimum 75%, Missing); thymus: 50.9091% (minimum 65%, Missing); thyroid gland: 59.1549% (minimum 60%, Approved); urinary bladder: 56.3758% (minimum 65%, Approved)",-0.140909,-0.193976,-0.166667,0,3,partial,6,8.2,8.1,"lymph node: 8.2 nTPM (protected, limit 3); thymus: 8.1 nTPM (manageable, limit 5); urinary bladder: 6.5 nTPM (protected, limit 4); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); kidney: 5.8 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); bone marrow: 5.5 nTPM (vital, limit 2); rectum: 4.6 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); cerebellum: 3.8 nTPM (vital, limit 2); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 2); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128059,PPAT,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 58.7413% (minimum 75%, Baseline (adaptation disabled)); amygdala: 71.7949% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.1864% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 60.4317% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.8525% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.4317% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.5882% (minimum 75%, Baseline (adaptation disabled)); colon: 68.8525% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.2927% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.1417% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 73.6842% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.1864% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.1549% (minimum 75%, Baseline (adaptation disabled)); liver: 58.3333% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.6024% (minimum 70%, Baseline (adaptation disabled)); midbrain: 70.5882% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.5745% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 68.8525% (minimum 70%, Baseline (adaptation disabled)); rectum: 64.6154% (minimum 70%, Baseline (adaptation disabled)); retina: 66.1417% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.4317% (minimum 70%, Baseline (adaptation disabled)); small intestine: 73.0435% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.5882% (minimum 75%, Baseline (adaptation disabled)); thymus: 50.9091% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 59.1549% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 56.3758% (minimum 70%, Baseline (adaptation disabled))",-0.140909,-0.193976,-0.166667,0,3,partial,6,8.2,8.1,"lymph node: 8.2 nTPM (protected, limit 3); thymus: 8.1 nTPM (manageable, limit 5); urinary bladder: 6.5 nTPM (protected, limit 3); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); kidney: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); bone marrow: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); rectum: 4.6 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.8 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128059,PPAT,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.4762% (minimum 95%, Enhanced); amygdala: 43.8017% (minimum 99%, Missing); basal ganglia: 4.5572% (minimum 99%, Missing); bone marrow: 11.6740% (minimum 99%, Missing); cerebellum: 35.0993% (minimum 99%, Missing); cerebral cortex: 40.7692% (minimum 95%, Enhanced); choroid plexus: 73.6111% (minimum 99%, Missing); colon: 56.9892% (minimum 97%, Missing); duodenum: 45.2991% (minimum 99%, Missing); esophagus: 73.6111% (minimum 80%, Enhanced); heart muscle: 28.8043% (minimum 95%, Enhanced); hippocampal formation: 39.5522% (minimum 99%, Missing); hypothalamus: 42.7419% (minimum 99%, Missing); kidney: 23.8739% (minimum 99%, Missing); liver: 27.1795% (minimum 95%, Enhanced); lung: 27.3196% (minimum 95%, Enhanced); lymph node: 20.9486% (minimum 97%, Missing); midbrain: 41.4062% (minimum 99%, Missing); pancreas: 70.6667% (minimum 95%, Enhanced); pituitary gland: 44.9153% (minimum 99%, Missing); rectum: 84.1270% (minimum 97%, Missing); retina: 72.6027% (minimum 99%, Missing); salivary gland: 63.0952% (minimum 80%, Enhanced); skeletal muscle: 68.8312% (minimum 95%, Enhanced); small intestine: 43.8017% (minimum 99%, Missing); smooth muscle: 85.4839% (minimum 95%, Enhanced); spinal cord: 54.0816% (minimum 99%, Missing); spleen: 26.3682% (minimum 60%, Enhanced); stomach: 58.2418% (minimum 80%, Enhanced); thymus: 9.1379% (minimum 95%, Missing); thyroid gland: 55.7895% (minimum 60%, Enhanced); tongue: 80.3030% (minimum 97%, Missing); urinary bladder: 50.9615% (minimum 80%, Enhanced)",-0.858621,-0.760514,-0.944428,0,15,partial,111,20,52.7,"basal ganglia: 111 nTPM (vital, limit 1); thymus: 52.7 nTPM (manageable, limit 5); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 2); kidney: 16.9 nTPM (vital, limit 1); liver: 14.2 nTPM (vital, limit 6); lung: 14.1 nTPM (vital, limit 6); heart muscle: 13.1 nTPM (vital, limit 6); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 6); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),94,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128271,ADORA2A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.4762% (minimum 60%, Enhanced); amygdala: 43.8017% (minimum 75%, Missing); basal ganglia: 4.5572% (minimum 75%, Missing); bone marrow: 11.6740% (minimum 75%, Missing); cerebellum: 35.0993% (minimum 75%, Missing); cerebral cortex: 40.7692% (minimum 60%, Enhanced); choroid plexus: 73.6111% (minimum 75%, Missing); colon: 56.9892% (minimum 70%, Missing); duodenum: 45.2991% (minimum 75%, Missing); heart muscle: 28.8043% (minimum 60%, Enhanced); hippocampal formation: 39.5522% (minimum 75%, Missing); hypothalamus: 42.7419% (minimum 75%, Missing); kidney: 23.8739% (minimum 75%, Missing); liver: 27.1795% (minimum 60%, Enhanced); lung: 27.3196% (minimum 60%, Enhanced); lymph node: 20.9486% (minimum 70%, Missing); midbrain: 41.4062% (minimum 75%, Missing); pituitary gland: 44.9153% (minimum 75%, Missing); retina: 72.6027% (minimum 75%, Missing); small intestine: 43.8017% (minimum 75%, Missing); spinal cord: 54.0816% (minimum 75%, Missing); spleen: 26.3682% (minimum 50%, Enhanced); thymus: 9.1379% (minimum 65%, Missing); urinary bladder: 50.9615% (minimum 55%, Enhanced)",-0.558621,-0.490514,-0.704428,0,15,partial,111,20,52.7,"basal ganglia: 111 nTPM (vital, limit 1); thymus: 52.7 nTPM (manageable, limit 5); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 2); kidney: 16.9 nTPM (vital, limit 1); liver: 14.2 nTPM (vital, limit 6); lung: 14.1 nTPM (vital, limit 6); heart muscle: 13.1 nTPM (vital, limit 6); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 6); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),94,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128271,ADORA2A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.4762% (minimum 60%, Enhanced); amygdala: 43.8017% (minimum 75%, Missing); basal ganglia: 4.5572% (minimum 75%, Missing); bone marrow: 11.6740% (minimum 75%, Missing); cerebellum: 35.0993% (minimum 75%, Missing); cerebral cortex: 40.7692% (minimum 60%, Enhanced); choroid plexus: 73.6111% (minimum 75%, Missing); colon: 56.9892% (minimum 70%, Missing); duodenum: 45.2991% (minimum 75%, Missing); heart muscle: 28.8043% (minimum 60%, Enhanced); hippocampal formation: 39.5522% (minimum 75%, Missing); hypothalamus: 42.7419% (minimum 75%, Missing); kidney: 23.8739% (minimum 75%, Missing); liver: 27.1795% (minimum 60%, Enhanced); lung: 27.3196% (minimum 60%, Enhanced); lymph node: 20.9486% (minimum 70%, Missing); midbrain: 41.4062% (minimum 75%, Missing); pituitary gland: 44.9153% (minimum 75%, Missing); retina: 72.6027% (minimum 75%, Missing); small intestine: 43.8017% (minimum 75%, Missing); spinal cord: 54.0816% (minimum 75%, Missing); spleen: 26.3682% (minimum 50%, Enhanced); thymus: 9.1379% (minimum 65%, Missing); urinary bladder: 50.9615% (minimum 55%, Enhanced)",-0.558621,-0.490514,-0.704428,0,15,partial,111,20,52.7,"basal ganglia: 111 nTPM (vital, limit 1); thymus: 52.7 nTPM (manageable, limit 5); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 3); kidney: 16.9 nTPM (vital, limit 1); liver: 14.2 nTPM (vital, limit 6); lung: 14.1 nTPM (vital, limit 6); heart muscle: 13.1 nTPM (vital, limit 6); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 6); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),94,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128271,ADORA2A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.4762% (minimum 60%, Enhanced); amygdala: 43.8017% (minimum 75%, Missing); basal ganglia: 4.5572% (minimum 75%, Missing); bone marrow: 11.6740% (minimum 75%, Missing); cerebellum: 35.0993% (minimum 75%, Missing); cerebral cortex: 40.7692% (minimum 60%, Enhanced); choroid plexus: 73.6111% (minimum 75%, Missing); colon: 56.9892% (minimum 70%, Missing); duodenum: 45.2991% (minimum 75%, Missing); heart muscle: 28.8043% (minimum 60%, Enhanced); hippocampal formation: 39.5522% (minimum 75%, Missing); hypothalamus: 42.7419% (minimum 75%, Missing); kidney: 23.8739% (minimum 75%, Missing); liver: 27.1795% (minimum 60%, Enhanced); lung: 27.3196% (minimum 60%, Enhanced); lymph node: 20.9486% (minimum 70%, Missing); midbrain: 41.4062% (minimum 75%, Missing); pituitary gland: 44.9153% (minimum 75%, Missing); retina: 72.6027% (minimum 75%, Missing); small intestine: 43.8017% (minimum 75%, Missing); spinal cord: 54.0816% (minimum 75%, Missing); spleen: 26.3682% (minimum 50%, Enhanced); thymus: 9.1379% (minimum 65%, Missing); urinary bladder: 50.9615% (minimum 55%, Enhanced)",-0.558621,-0.490514,-0.704428,0,15,partial,111,20,52.7,"basal ganglia: 111 nTPM (vital, limit 1); thymus: 52.7 nTPM (manageable, limit 5); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 3); kidney: 16.9 nTPM (vital, limit 1); liver: 14.2 nTPM (vital, limit 6); lung: 14.1 nTPM (vital, limit 6); heart muscle: 13.1 nTPM (vital, limit 6); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 6); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),94,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128271,ADORA2A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6279% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 50.4762% (minimum 75%, Baseline (adaptation disabled)); amygdala: 43.8017% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 4.5572% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 11.6740% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 35.0993% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 40.7692% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.6111% (minimum 75%, Baseline (adaptation disabled)); colon: 56.9892% (minimum 70%, Baseline (adaptation disabled)); duodenum: 45.2991% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 28.8043% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 39.5522% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 42.7419% (minimum 75%, Baseline (adaptation disabled)); kidney: 23.8739% (minimum 75%, Baseline (adaptation disabled)); liver: 27.1795% (minimum 75%, Baseline (adaptation disabled)); lung: 27.3196% (minimum 75%, Baseline (adaptation disabled)); lymph node: 20.9486% (minimum 70%, Baseline (adaptation disabled)); midbrain: 41.4062% (minimum 75%, Baseline (adaptation disabled)); pancreas: 70.6667% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 44.9153% (minimum 75%, Baseline (adaptation disabled)); retina: 72.6027% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.0952% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 68.8312% (minimum 75%, Baseline (adaptation disabled)); small intestine: 43.8017% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 54.0816% (minimum 75%, Baseline (adaptation disabled)); spleen: 26.3682% (minimum 65%, Baseline (adaptation disabled)); stomach: 58.2418% (minimum 70%, Baseline (adaptation disabled)); thymus: 9.1379% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.7895% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 50.9615% (minimum 70%, Baseline (adaptation disabled))",-0.558621,-0.490514,-0.704428,0,15,partial,111,20,52.7,"basal ganglia: 111 nTPM (vital, limit 1); thymus: 52.7 nTPM (manageable, limit 5); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 3); kidney: 16.9 nTPM (vital, limit 1); spleen: 14.8 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 3); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); stomach: 3.8 nTPM (protected, limit 3); salivary gland: 3.1 nTPM (protected, limit 3); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),94,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128271,ADORA2A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 26.1194% (minimum 99%, Missing); thymus: 71.2209% (minimum 95%, Missing)",-0.237791,0.03,-0.728806,0,2,partial,69.3,1.6,9.9,"bone marrow: 69.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128322,IGLL1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 26.1194% (minimum 75%, Missing)",0.0622093,0.3,-0.488806,0,2,partial,69.3,1.6,9.9,"bone marrow: 69.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128322,IGLL1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 26.1194% (minimum 75%, Missing)",0.0622093,0.3,-0.488806,0,2,partial,69.3,1.6,9.9,"bone marrow: 69.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128322,IGLL1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 26.1194% (minimum 75%, Missing)",0.0622093,0.3,-0.488806,0,2,partial,69.3,1.6,9.9,"bone marrow: 69.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128322,IGLL1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 26.1194% (minimum 75%, Baseline (adaptation disabled))",0.0622093,0.238697,-0.488806,0,2,partial,69.3,1.6,9.9,"bone marrow: 69.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128322,IGLL1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.3767% (minimum 99%, Missing); amygdala: 97.9937% (minimum 99%, Missing); basal ganglia: 97.6842% (minimum 99%, Missing); bone marrow: 96.8685% (minimum 99%, Missing); cerebellum: 98.6185% (minimum 99%, Missing); cerebral cortex: 92.8000% (minimum 99%, Missing); choroid plexus: 89.5753% (minimum 99%, Missing); colon: 96.5661% (minimum 97%, Missing); duodenum: 97.0711% (minimum 99%, Missing); esophagus: 87.3001% (minimum 97%, Missing); heart muscle: 94.8875% (minimum 99%, Missing); hippocampal formation: 97.6842% (minimum 99%, Missing); hypothalamus: 97.0711% (minimum 99%, Missing); kidney: 97.6842% (minimum 99%, Missing); lung: 95.0820% (minimum 99%, Missing); lymph node: 96.3655% (minimum 97%, Missing); midbrain: 97.8903% (minimum 99%, Missing); pancreas: 91.7903% (minimum 99%, Missing); pituitary gland: 95.1795% (minimum 99%, Missing); retina: 96.4657% (minimum 99%, Missing); salivary gland: 90.2724% (minimum 97%, Missing); skeletal muscle: 94.4049% (minimum 99%, Missing); skin: 78.6441% (minimum 95%, Missing); small intestine: 96.1658% (minimum 99%, Missing); spinal cord: 97.2746% (minimum 99%, Missing); stomach: 91.4286% (minimum 97%, Missing); thyroid gland: 92.0635% (minimum 95%, Missing); urinary bladder: 93.9271% (minimum 97%, Missing)",-0.163559,-0.0969991,-0.0942471,0,80,unavailable,10.8,13.5,25.2,"skin: 25.2 nTPM (manageable, limit 5); esophagus: 13.5 nTPM (protected, limit 2); choroid plexus: 10.8 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); skeletal muscle: 5.5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); retina: 3.4 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); bone marrow: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128346,C22orf23,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.136441,0.173001,0.145753,0,80,unavailable,10.8,13.5,25.2,"skin: 25.2 nTPM (manageable, limit 5); esophagus: 13.5 nTPM (protected, limit 2); choroid plexus: 10.8 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); skeletal muscle: 5.5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); retina: 3.4 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); bone marrow: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128346,C22orf23,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.136441,0.173001,0.145753,0,80,unavailable,10.8,13.5,25.2,"skin: 25.2 nTPM (manageable, limit 5); esophagus: 13.5 nTPM (protected, limit 3); choroid plexus: 10.8 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); skeletal muscle: 5.5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); retina: 3.4 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); bone marrow: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128346,C22orf23,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.136441,0.173001,0.145753,0,80,unavailable,10.8,13.5,25.2,"skin: 25.2 nTPM (manageable, limit 5); esophagus: 13.5 nTPM (protected, limit 3); choroid plexus: 10.8 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); skeletal muscle: 5.5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); retina: 3.4 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); bone marrow: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128346,C22orf23,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.136441,0.173001,0.145753,0,80,unavailable,10.8,13.5,25.2,"skin: 25.2 nTPM (manageable, limit 5); esophagus: 13.5 nTPM (protected, limit 3); choroid plexus: 10.8 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); skeletal muscle: 5.5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); retina: 3.4 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); bone marrow: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128346,C22orf23,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.3738% (minimum 95%, Missing); adrenal gland: 58.5034% (minimum 99%, Missing); amygdala: 87.7551% (minimum 99%, Missing); basal ganglia: 88.6598% (minimum 99%, Missing); bone marrow: 73.5043% (minimum 99%, Missing); cerebellum: 96.6292% (minimum 99%, Missing); cerebral cortex: 91.4894% (minimum 99%, Missing); choroid plexus: 59.3103% (minimum 99%, Missing); colon: 72.2689% (minimum 97%, Missing); duodenum: 71.0744% (minimum 99%, Missing); esophagus: 78.8991% (minimum 97%, Missing); heart muscle: 61.8705% (minimum 99%, Missing); hippocampal formation: 89.5833% (minimum 99%, Missing); hypothalamus: 87.7551% (minimum 99%, Missing); kidney: 72.2689% (minimum 99%, Missing); liver: 75.4386% (minimum 99%, Missing); lung: 72.2689% (minimum 99%, Missing); lymph node: 36.1345% (minimum 97%, Missing); midbrain: 86.8687% (minimum 99%, Missing); pancreas: 74.7826% (minimum 99%, Missing); parathyroid gland: 63.2353% (minimum 97%, Missing); pituitary gland: 72.2689% (minimum 99%, Missing); rectum: 76.1062% (minimum 97%, Missing); retina: 88.6598% (minimum 99%, Missing); salivary gland: 64.6617% (minimum 97%, Missing); skeletal muscle: 93.4783% (minimum 99%, Missing); skin: 84.3137% (minimum 95%, Missing); small intestine: 69.9187% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 87.7551% (minimum 99%, Missing); spleen: 42.5743% (minimum 95%, Missing); stomach: 65.1515% (minimum 97%, Missing); thymus: 62.3188% (minimum 95%, Missing); thyroid gland: 74.7826% (minimum 95%, Missing); tongue: 86.8687% (minimum 97%, Missing); urinary bladder: 66.1538% (minimum 97%, Missing)",-0.524257,-0.608655,-0.404966,0,80,unavailable,6.1,15.2,11.6,"lymph node: 15.2 nTPM (protected, limit 2); spleen: 11.6 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); parathyroid gland: 5 nTPM (protected, limit 2); salivary gland: 4.7 nTPM (protected, limit 2); stomach: 4.6 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); pituitary gland: 3.3 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128394,APOBEC3F,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.5034% (minimum 75%, Missing); bone marrow: 73.5043% (minimum 75%, Missing); choroid plexus: 59.3103% (minimum 75%, Missing); duodenum: 71.0744% (minimum 75%, Missing); heart muscle: 61.8705% (minimum 75%, Missing); kidney: 72.2689% (minimum 75%, Missing); lung: 72.2689% (minimum 75%, Missing); lymph node: 36.1345% (minimum 70%, Missing); pancreas: 74.7826% (minimum 75%, Missing); parathyroid gland: 63.2353% (minimum 70%, Missing); pituitary gland: 72.2689% (minimum 75%, Missing); salivary gland: 64.6617% (minimum 70%, Missing); small intestine: 69.9187% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 42.5743% (minimum 65%, Missing); stomach: 65.1515% (minimum 70%, Missing); thymus: 62.3188% (minimum 65%, Missing); urinary bladder: 66.1538% (minimum 70%, Missing)",-0.224257,-0.338655,-0.164966,0,80,unavailable,6.1,15.2,11.6,"lymph node: 15.2 nTPM (protected, limit 2); spleen: 11.6 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); parathyroid gland: 5 nTPM (protected, limit 2); salivary gland: 4.7 nTPM (protected, limit 2); stomach: 4.6 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); pituitary gland: 3.3 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128394,APOBEC3F,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.5034% (minimum 75%, Missing); bone marrow: 73.5043% (minimum 75%, Missing); choroid plexus: 59.3103% (minimum 75%, Missing); duodenum: 71.0744% (minimum 75%, Missing); heart muscle: 61.8705% (minimum 75%, Missing); kidney: 72.2689% (minimum 75%, Missing); lung: 72.2689% (minimum 75%, Missing); lymph node: 36.1345% (minimum 70%, Missing); pancreas: 74.7826% (minimum 75%, Missing); parathyroid gland: 63.2353% (minimum 70%, Missing); pituitary gland: 72.2689% (minimum 75%, Missing); salivary gland: 64.6617% (minimum 70%, Missing); small intestine: 69.9187% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 42.5743% (minimum 65%, Missing); stomach: 65.1515% (minimum 70%, Missing); thymus: 62.3188% (minimum 65%, Missing); urinary bladder: 66.1538% (minimum 70%, Missing)",-0.224257,-0.338655,-0.164966,0,80,unavailable,6.1,15.2,11.6,"lymph node: 15.2 nTPM (protected, limit 3); spleen: 11.6 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); parathyroid gland: 5 nTPM (protected, limit 3); salivary gland: 4.7 nTPM (protected, limit 3); stomach: 4.6 nTPM (protected, limit 3); urinary bladder: 4.4 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128394,APOBEC3F,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.5034% (minimum 75%, Missing); bone marrow: 73.5043% (minimum 75%, Missing); choroid plexus: 59.3103% (minimum 75%, Missing); duodenum: 71.0744% (minimum 75%, Missing); heart muscle: 61.8705% (minimum 75%, Missing); kidney: 72.2689% (minimum 75%, Missing); lung: 72.2689% (minimum 75%, Missing); lymph node: 36.1345% (minimum 70%, Missing); pancreas: 74.7826% (minimum 75%, Missing); parathyroid gland: 63.2353% (minimum 70%, Missing); pituitary gland: 72.2689% (minimum 75%, Missing); salivary gland: 64.6617% (minimum 70%, Missing); small intestine: 69.9187% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 42.5743% (minimum 65%, Missing); stomach: 65.1515% (minimum 70%, Missing); thymus: 62.3188% (minimum 65%, Missing); urinary bladder: 66.1538% (minimum 70%, Missing)",-0.224257,-0.338655,-0.164966,0,80,unavailable,6.1,15.2,11.6,"lymph node: 15.2 nTPM (protected, limit 3); spleen: 11.6 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); parathyroid gland: 5 nTPM (protected, limit 3); salivary gland: 4.7 nTPM (protected, limit 3); stomach: 4.6 nTPM (protected, limit 3); urinary bladder: 4.4 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128394,APOBEC3F,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.5034% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 73.5043% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 59.3103% (minimum 75%, Baseline (adaptation disabled)); duodenum: 71.0744% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 61.8705% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.2689% (minimum 75%, Baseline (adaptation disabled)); lung: 72.2689% (minimum 75%, Baseline (adaptation disabled)); lymph node: 36.1345% (minimum 70%, Baseline (adaptation disabled)); pancreas: 74.7826% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.2353% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.2689% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.6617% (minimum 70%, Baseline (adaptation disabled)); small intestine: 69.9187% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 42.5743% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.1515% (minimum 70%, Baseline (adaptation disabled)); thymus: 62.3188% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 66.1538% (minimum 70%, Baseline (adaptation disabled))",-0.224257,-0.338655,-0.164966,0,80,unavailable,6.1,15.2,11.6,"lymph node: 15.2 nTPM (protected, limit 3); spleen: 11.6 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); parathyroid gland: 5 nTPM (protected, limit 3); salivary gland: 4.7 nTPM (protected, limit 3); stomach: 4.6 nTPM (protected, limit 3); urinary bladder: 4.4 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128394,APOBEC3F,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.7049% (minimum 99%, Missing); basal ganglia: 95.8199% (minimum 99%, Missing); bone marrow: 94.0063% (minimum 98%, Approved); choroid plexus: 69.6262% (minimum 99%, Missing); hippocampal formation: 96.4401% (minimum 99%, Missing); hypothalamus: 95.8199% (minimum 99%, Missing); lung: 97.3856% (minimum 98%, Approved); pituitary gland: 95.5128% (minimum 99%, Missing)",0.0334983,0.0112903,-0.293738,0,11,partial,13,1.2,0.9,"choroid plexus: 13 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128408,RIBC2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 69.6262% (minimum 75%, Missing)",0.333498,0.3,-0.0537383,0,11,partial,13,1.2,0.9,"choroid plexus: 13 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128408,RIBC2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 69.6262% (minimum 75%, Missing)",0.333498,0.3,-0.0537383,0,11,partial,13,1.2,0.9,"choroid plexus: 13 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128408,RIBC2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 69.6262% (minimum 75%, Missing)",0.333498,0.3,-0.0537383,0,11,partial,13,1.2,0.9,"choroid plexus: 13 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128408,RIBC2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 69.6262% (minimum 75%, Baseline (adaptation disabled))",0.320684,0.26129,-0.0537383,0,11,partial,13,1.2,0.9,"choroid plexus: 13 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128408,RIBC2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7230% (minimum 95%, Missing); adrenal gland: 70.4762% (minimum 99%, Missing); amygdala: 51.0345% (minimum 99%, Missing); basal ganglia: 52.4823% (minimum 99%, Missing); bone marrow: 49.2239% (minimum 99%, Missing); cerebellum: 67.2727% (minimum 99%, Missing); cerebral cortex: 50.2262% (minimum 99%, Missing); choroid plexus: 38.0137% (minimum 99%, Missing); colon: 60.4905% (minimum 97%, Missing); duodenum: 70.0315% (minimum 99%, Missing); esophagus: 71.3826% (minimum 97%, Missing); heart muscle: 81.9188% (minimum 95%, Enhanced); hippocampal formation: 46.3466% (minimum 99%, Missing); hypothalamus: 55.5000% (minimum 99%, Missing); kidney: 82.8358% (minimum 99%, Missing); lung: 79.8561% (minimum 99%, Missing); lymph node: 81.3187% (minimum 97%, Missing); midbrain: 44.8485% (minimum 99%, Missing); pancreas: 82.8358% (minimum 99%, Missing); parathyroid gland: 88.4462% (minimum 97%, Missing); pituitary gland: 78.1690% (minimum 99%, Missing); rectum: 70.2532% (minimum 97%, Missing); retina: 79.5699% (minimum 99%, Missing); salivary gland: 78.7234% (minimum 97%, Missing); skeletal muscle: 82.2222% (minimum 99%, Missing); skin: 86.3813% (minimum 95%, Missing); small intestine: 68.7307% (minimum 99%, Missing); smooth muscle: 71.1538% (minimum 99%, Missing); spinal cord: 38.4749% (minimum 99%, Missing); spleen: 63.0682% (minimum 95%, Missing); stomach: 68.9441% (minimum 97%, Missing); thymus: 88.4462% (minimum 95%, Missing); thyroid gland: 81.6176% (minimum 95%, Missing); tongue: 89.5161% (minimum 97%, Missing); urinary bladder: 83.4586% (minimum 97%, Missing)",-0.319318,-0.365095,-0.609863,0,6,partial,36.2,14.5,13,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 2); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 2); pituitary gland: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 2); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); tongue: 2.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128487,SPECC1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7230% (minimum 65%, Missing); adrenal gland: 70.4762% (minimum 75%, Missing); amygdala: 51.0345% (minimum 75%, Missing); basal ganglia: 52.4823% (minimum 75%, Missing); bone marrow: 49.2239% (minimum 75%, Missing); cerebellum: 67.2727% (minimum 75%, Missing); cerebral cortex: 50.2262% (minimum 75%, Missing); choroid plexus: 38.0137% (minimum 75%, Missing); colon: 60.4905% (minimum 70%, Missing); duodenum: 70.0315% (minimum 75%, Missing); hippocampal formation: 46.3466% (minimum 75%, Missing); hypothalamus: 55.5000% (minimum 75%, Missing); midbrain: 44.8485% (minimum 75%, Missing); small intestine: 68.7307% (minimum 75%, Missing); smooth muscle: 71.1538% (minimum 75%, Missing); spinal cord: 38.4749% (minimum 75%, Missing); spleen: 63.0682% (minimum 65%, Missing); stomach: 68.9441% (minimum 70%, Missing)",-0.0193182,-0.0950954,-0.369863,0,6,partial,36.2,14.5,13,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 2); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 2); pituitary gland: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 2); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); tongue: 2.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128487,SPECC1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7230% (minimum 65%, Missing); adrenal gland: 70.4762% (minimum 75%, Missing); amygdala: 51.0345% (minimum 75%, Missing); basal ganglia: 52.4823% (minimum 75%, Missing); bone marrow: 49.2239% (minimum 75%, Missing); cerebellum: 67.2727% (minimum 75%, Missing); cerebral cortex: 50.2262% (minimum 75%, Missing); choroid plexus: 38.0137% (minimum 75%, Missing); colon: 60.4905% (minimum 70%, Missing); duodenum: 70.0315% (minimum 75%, Missing); hippocampal formation: 46.3466% (minimum 75%, Missing); hypothalamus: 55.5000% (minimum 75%, Missing); midbrain: 44.8485% (minimum 75%, Missing); small intestine: 68.7307% (minimum 75%, Missing); smooth muscle: 71.1538% (minimum 75%, Missing); spinal cord: 38.4749% (minimum 75%, Missing); spleen: 63.0682% (minimum 65%, Missing); stomach: 68.9441% (minimum 70%, Missing)",-0.0193182,-0.0950954,-0.369863,0,6,partial,36.2,14.5,13,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 3); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 3); pituitary gland: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 3); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128487,SPECC1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7230% (minimum 65%, Missing); adrenal gland: 70.4762% (minimum 75%, Missing); amygdala: 51.0345% (minimum 75%, Missing); basal ganglia: 52.4823% (minimum 75%, Missing); bone marrow: 49.2239% (minimum 75%, Missing); cerebellum: 67.2727% (minimum 75%, Missing); cerebral cortex: 50.2262% (minimum 75%, Missing); choroid plexus: 38.0137% (minimum 75%, Missing); colon: 60.4905% (minimum 70%, Missing); duodenum: 70.0315% (minimum 75%, Missing); hippocampal formation: 46.3466% (minimum 75%, Missing); hypothalamus: 55.5000% (minimum 75%, Missing); midbrain: 44.8485% (minimum 75%, Missing); small intestine: 68.7307% (minimum 75%, Missing); smooth muscle: 71.1538% (minimum 75%, Missing); spinal cord: 38.4749% (minimum 75%, Missing); spleen: 63.0682% (minimum 65%, Missing); stomach: 68.9441% (minimum 70%, Missing)",-0.0193182,-0.0950954,-0.369863,0,6,partial,36.2,14.5,13,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 3); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 3); pituitary gland: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 3); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128487,SPECC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7230% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 70.4762% (minimum 75%, Baseline (adaptation disabled)); amygdala: 51.0345% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 52.4823% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 49.2239% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.2727% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.2262% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 38.0137% (minimum 75%, Baseline (adaptation disabled)); colon: 60.4905% (minimum 70%, Baseline (adaptation disabled)); duodenum: 70.0315% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 46.3466% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.5000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 44.8485% (minimum 75%, Baseline (adaptation disabled)); small intestine: 68.7307% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.1538% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 38.4749% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.0682% (minimum 65%, Baseline (adaptation disabled)); stomach: 68.9441% (minimum 70%, Baseline (adaptation disabled))",-0.0193182,-0.0950954,-0.369863,0,6,partial,36.2,14.5,13,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 3); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 3); pituitary gland: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 3); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); heart muscle: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 3); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128487,SPECC1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 87.0299% (minimum 99%, Missing); basal ganglia: 90.7035% (minimum 99%, Missing); cerebellum: 67.8827% (minimum 99%, Missing); cerebral cortex: 73.1361% (minimum 99%, Missing); choroid plexus: 97.4096% (minimum 99%, Missing); hippocampal formation: 85.8706% (minimum 99%, Missing); hypothalamus: 79.6206% (minimum 99%, Missing); midbrain: 84.1492% (minimum 99%, Missing); pituitary gland: 96.6274% (minimum 99%, Missing); retina: 78.0035% (minimum 99%, Missing); smooth muscle: 94.1575% (minimum 95%, Enhanced); spinal cord: 90.4762% (minimum 99%, Missing)",0.0225216,0.00938144,-0.311173,0,7,partial,85.4,19.5,5.1,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 12); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 12); smooth muscle: 11.2 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128596,CCDC136,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 67.8827% (minimum 75%, Missing); cerebral cortex: 73.1361% (minimum 75%, Missing)",0.322522,0.279381,-0.0711734,0,7,partial,85.4,19.5,5.1,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 12); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 12); smooth muscle: 11.2 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128596,CCDC136,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 67.8827% (minimum 75%, Missing); cerebral cortex: 73.1361% (minimum 75%, Missing)",0.322522,0.279381,-0.0711734,0,7,partial,85.4,19.5,5.1,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 12); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 12); smooth muscle: 11.2 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128596,CCDC136,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 67.8827% (minimum 75%, Missing); cerebral cortex: 73.1361% (minimum 75%, Missing)",0.322522,0.279381,-0.0711734,0,7,partial,85.4,19.5,5.1,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 12); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 12); smooth muscle: 11.2 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128596,CCDC136,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 67.8827% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.1361% (minimum 75%, Baseline (adaptation disabled))",0.322522,0.2025,-0.0711734,0,7,partial,85.4,19.5,5.1,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 3); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 3); smooth muscle: 11.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); heart muscle: 5.5 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 3); skeletal muscle: 4.2 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128596,CCDC136,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.2740% (minimum 99%, Missing); basal ganglia: 55.0000% (minimum 99%, Missing); cerebellum: 97.7778% (minimum 98%, Approved); cerebral cortex: 95.6522% (minimum 99%, Missing); choroid plexus: 97.7778% (minimum 99%, Missing); heart muscle: 97.7778% (minimum 98%, Approved); hippocampal formation: 95.6522% (minimum 99%, Missing); hypothalamus: 24.7191% (minimum 99%, Missing); midbrain: 68.7500% (minimum 99%, Missing); pituitary gland: 60.2740% (minimum 99%, Missing); retina: 64.7059% (minimum 99%, Missing); spinal cord: 97.7778% (minimum 99%, Missing)",0.05,0.03,-0.742809,0,2,partial,13.4,0,0.1,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128610,FEZF1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.2740% (minimum 75%, Missing); basal ganglia: 55.0000% (minimum 75%, Missing); hypothalamus: 24.7191% (minimum 75%, Missing); midbrain: 68.7500% (minimum 75%, Missing); pituitary gland: 60.2740% (minimum 75%, Missing); retina: 64.7059% (minimum 75%, Missing)",0.35,0.3,-0.502809,0,2,partial,13.4,0,0.1,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128610,FEZF1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.2740% (minimum 75%, Missing); basal ganglia: 55.0000% (minimum 75%, Missing); hypothalamus: 24.7191% (minimum 75%, Missing); midbrain: 68.7500% (minimum 75%, Missing); pituitary gland: 60.2740% (minimum 75%, Missing); retina: 64.7059% (minimum 75%, Missing)",0.35,0.3,-0.502809,0,2,partial,13.4,0,0.1,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128610,FEZF1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.2740% (minimum 75%, Missing); basal ganglia: 55.0000% (minimum 75%, Missing); hypothalamus: 24.7191% (minimum 75%, Missing); midbrain: 68.7500% (minimum 75%, Missing); pituitary gland: 60.2740% (minimum 75%, Missing); retina: 64.7059% (minimum 75%, Missing)",0.35,0.3,-0.502809,0,2,partial,13.4,0,0.1,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128610,FEZF1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.2740% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 24.7191% (minimum 75%, Baseline (adaptation disabled)); midbrain: 68.7500% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 60.2740% (minimum 75%, Baseline (adaptation disabled)); retina: 64.7059% (minimum 75%, Baseline (adaptation disabled))",0.327778,0.3,-0.502809,0,2,partial,13.4,0,0.1,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128610,FEZF1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.6667% (minimum 95%, Missing); adrenal gland: 94.6429% (minimum 99%, Missing); amygdala: 89.8305% (minimum 99%, Missing); basal ganglia: 91.3793% (minimum 99%, Missing); bone marrow: 96.3636% (minimum 99%, Missing); cerebral cortex: 91.3793% (minimum 99%, Missing); choroid plexus: 92.9825% (minimum 99%, Missing); colon: 91.3793% (minimum 97%, Missing); duodenum: 86.8852% (minimum 99%, Missing); heart muscle: 94.6429% (minimum 99%, Missing); hippocampal formation: 88.3333% (minimum 99%, Missing); hypothalamus: 85.4839% (minimum 99%, Missing); kidney: 91.3793% (minimum 99%, Missing); liver: 46.4912% (minimum 99%, Missing); midbrain: 76.8116% (minimum 99%, Missing); pancreas: 82.8125% (minimum 99%, Missing); parathyroid gland: 34.8684% (minimum 97%, Missing); pituitary gland: 86.8852% (minimum 99%, Missing); rectum: 92.9825% (minimum 97%, Missing); retina: 79.1045% (minimum 99%, Missing); salivary gland: 80.3030% (minimum 97%, Missing); skeletal muscle: 55.7895% (minimum 99%, Missing); small intestine: 91.3793% (minimum 99%, Missing); smooth muscle: 84.1270% (minimum 99%, Missing); spinal cord: 65.4321% (minimum 99%, Missing); stomach: 92.9825% (minimum 97%, Missing); thyroid gland: 76.8116% (minimum 95%, Missing); tongue: 81.5385% (minimum 97%, Missing)",-0.243333,-0.621316,-0.525088,0,3,partial,6.1,9.9,2.2,"parathyroid gland: 9.9 nTPM (protected, limit 2); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128655,PDE11A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 46.4912% (minimum 75%, Missing); parathyroid gland: 34.8684% (minimum 70%, Missing); skeletal muscle: 55.7895% (minimum 75%, Missing); spinal cord: 65.4321% (minimum 75%, Missing)",0.0566667,-0.351316,-0.285088,0,3,partial,6.1,9.9,2.2,"parathyroid gland: 9.9 nTPM (protected, limit 2); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128655,PDE11A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 46.4912% (minimum 75%, Missing); parathyroid gland: 34.8684% (minimum 70%, Missing); skeletal muscle: 55.7895% (minimum 75%, Missing); spinal cord: 65.4321% (minimum 75%, Missing)",0.0566667,-0.351316,-0.285088,0,3,partial,6.1,9.9,2.2,"parathyroid gland: 9.9 nTPM (protected, limit 3); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128655,PDE11A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 46.4912% (minimum 75%, Missing); parathyroid gland: 34.8684% (minimum 70%, Missing); skeletal muscle: 55.7895% (minimum 75%, Missing); spinal cord: 65.4321% (minimum 75%, Missing)",0.0566667,-0.351316,-0.285088,0,3,partial,6.1,9.9,2.2,"parathyroid gland: 9.9 nTPM (protected, limit 3); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128655,PDE11A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 46.4912% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 34.8684% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.7895% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.4321% (minimum 75%, Baseline (adaptation disabled))",0.0566667,-0.351316,-0.285088,0,3,partial,6.1,9.9,2.2,"parathyroid gland: 9.9 nTPM (protected, limit 3); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128655,PDE11A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.7500% (minimum 98%, Approved); bone marrow: 97.0588% (minimum 98%, Approved); cerebellum: 93.2203% (minimum 99%, Missing); cerebral cortex: 98.2143% (minimum 99%, Missing); choroid plexus: 51.8868% (minimum 99%, Missing); colon: 66.5323% (minimum 95%, Approved); duodenum: 49.6988% (minimum 99%, Missing); esophagus: 77.4648% (minimum 95%, Approved); heart muscle: 96.4912% (minimum 98%, Approved); hypothalamus: 98.8024% (minimum 99%, Missing); kidney: 91.6667% (minimum 98%, Approved); liver: 95.9302% (minimum 98%, Approved); lung: 90.6593% (minimum 98%, Approved); lymph node: 24.7748% (minimum 97%, Missing); pancreas: 97.0588% (minimum 98%, Approved); parathyroid gland: 91.1602% (minimum 95%, Approved); pituitary gland: 97.6331% (minimum 99%, Missing); rectum: 58.0986% (minimum 97%, Missing); salivary gland: 85.9375% (minimum 95%, Approved); skeletal muscle: 96.4912% (minimum 98%, Approved); skin: 39.0071% (minimum 95%, Missing); small intestine: 52.8846% (minimum 98%, Approved); smooth muscle: 94.8276% (minimum 98%, Approved); stomach: 86.8421% (minimum 95%, Approved); thymus: 91.6667% (minimum 95%, Missing); tongue: 90.1639% (minimum 97%, Missing); urinary bladder: 94.8276% (minimum 95%, Approved)",-0.559929,-0.722252,-0.493012,0,4,partial,16.7,50.1,25.8,"lymph node: 50.1 nTPM (protected, limit 2); skin: 25.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 2); rectum: 11.9 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 4); esophagus: 4.8 nTPM (protected, limit 4); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128886,ELL3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 51.8868% (minimum 75%, Missing); duodenum: 49.6988% (minimum 75%, Missing); lymph node: 24.7748% (minimum 70%, Missing); rectum: 58.0986% (minimum 70%, Missing); skin: 39.0071% (minimum 65%, Missing); small intestine: 52.8846% (minimum 70%, Approved)",-0.259929,-0.452252,-0.253012,0,4,partial,16.7,50.1,25.8,"lymph node: 50.1 nTPM (protected, limit 2); skin: 25.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 2); rectum: 11.9 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 4); esophagus: 4.8 nTPM (protected, limit 4); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128886,ELL3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 51.8868% (minimum 75%, Missing); duodenum: 49.6988% (minimum 75%, Missing); lymph node: 24.7748% (minimum 70%, Missing); rectum: 58.0986% (minimum 70%, Missing); skin: 39.0071% (minimum 65%, Missing); small intestine: 52.8846% (minimum 70%, Approved)",-0.259929,-0.452252,-0.253012,0,4,partial,16.7,50.1,25.8,"lymph node: 50.1 nTPM (protected, limit 3); skin: 25.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 2); rectum: 11.9 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 4); esophagus: 4.8 nTPM (protected, limit 4); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128886,ELL3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 51.8868% (minimum 75%, Missing); duodenum: 49.6988% (minimum 75%, Missing); lymph node: 24.7748% (minimum 70%, Missing); rectum: 58.0986% (minimum 70%, Missing); skin: 39.0071% (minimum 65%, Missing); small intestine: 52.8846% (minimum 70%, Approved)",-0.259929,-0.452252,-0.253012,0,4,partial,16.7,50.1,25.8,"lymph node: 50.1 nTPM (protected, limit 3); skin: 25.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 2); rectum: 11.9 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 4); esophagus: 4.8 nTPM (protected, limit 4); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128886,ELL3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 51.8868% (minimum 75%, Baseline (adaptation disabled)); colon: 66.5323% (minimum 70%, Baseline (adaptation disabled)); duodenum: 49.6988% (minimum 75%, Baseline (adaptation disabled)); lymph node: 24.7748% (minimum 70%, Baseline (adaptation disabled)); rectum: 58.0986% (minimum 70%, Baseline (adaptation disabled)); skin: 39.0071% (minimum 65%, Baseline (adaptation disabled)); small intestine: 52.8846% (minimum 75%, Baseline (adaptation disabled))",-0.259929,-0.452252,-0.253012,0,4,partial,16.7,50.1,25.8,"lymph node: 50.1 nTPM (protected, limit 3); skin: 25.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); lung: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000128886,ELL3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 99%, Missing); bone marrow: 46.1538% (minimum 95%, Enhanced); cerebral cortex: 75.0000% (minimum 95%, Enhanced); choroid plexus: 13.9535% (minimum 99%, Missing); esophagus: 75.0000% (minimum 80%, Enhanced); pituitary gland: 85.7143% (minimum 99%, Missing); retina: 0.0740% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 80%, Enhanced); skin: 54.5455% (minimum 60%, Enhanced)",-0.0545455,-0.2,-0.98926,0,1,partial,810,0.4,0.5,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129221,AIPL1,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); bone marrow: 46.1538% (minimum 60%, Enhanced); choroid plexus: 13.9535% (minimum 75%, Missing); retina: 0.0740% (minimum 75%, Missing)",0.0454545,0.05,-0.74926,0,1,partial,810,0.4,0.5,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129221,AIPL1,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); bone marrow: 46.1538% (minimum 60%, Enhanced); choroid plexus: 13.9535% (minimum 75%, Missing); retina: 0.0740% (minimum 75%, Missing)",0.0454545,0.05,-0.74926,0,1,partial,810,0.4,0.5,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129221,AIPL1,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); bone marrow: 46.1538% (minimum 60%, Enhanced); choroid plexus: 13.9535% (minimum 75%, Missing); retina: 0.0740% (minimum 75%, Missing)",0.0454545,0.05,-0.74926,0,1,partial,810,0.4,0.5,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129221,AIPL1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 46.1538% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 13.9535% (minimum 75%, Baseline (adaptation disabled)); retina: 0.0740% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); skin: 54.5455% (minimum 65%, Baseline (adaptation disabled))",-0.104545,-0.1,-0.74926,0,1,partial,810,0.4,0.5,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129221,AIPL1,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.0769% (minimum 95%, Enhanced); amygdala: 53.2468% (minimum 99%, Missing); basal ganglia: 52.5641% (minimum 99%, Missing); bone marrow: 91.1111% (minimum 95%, Enhanced); cerebellum: 69.4915% (minimum 95%, Enhanced); cerebral cortex: 55.4054% (minimum 95%, Enhanced); choroid plexus: 82.0000% (minimum 99%, Missing); duodenum: 80.3922% (minimum 95%, Enhanced); heart muscle: 70.6897% (minimum 95%, Enhanced); hippocampal formation: 56.9444% (minimum 99%, Missing); hypothalamus: 61.1940% (minimum 99%, Missing); kidney: 57.7465% (minimum 95%, Enhanced); liver: 53.9474% (minimum 95%, Enhanced); lung: 80.3922% (minimum 95%, Enhanced); midbrain: 54.6667% (minimum 99%, Missing); pancreas: 71.9298% (minimum 95%, Enhanced); parathyroid gland: 68.3333% (minimum 80%, Enhanced); pituitary gland: 64.0625% (minimum 99%, Missing); retina: 1.3175% (minimum 99%, Missing); skeletal muscle: 66.1290% (minimum 95%, Enhanced); small intestine: 75.9259% (minimum 95%, Enhanced); smooth muscle: 93.1818% (minimum 95%, Enhanced); spinal cord: 52.5641% (minimum 99%, Missing); stomach: 77.3585% (minimum 80%, Enhanced); thymus: 77.3585% (minimum 95%, Missing); tongue: 75.9259% (minimum 97%, Missing); urinary bladder: 78.8462% (minimum 80%, Enhanced)",-0.176415,-0.210741,-0.976825,0,1,partial,307.1,1.9,2.3,"retina: 307.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129535,NRL,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 53.2468% (minimum 75%, Missing); basal ganglia: 52.5641% (minimum 75%, Missing); cerebral cortex: 55.4054% (minimum 60%, Enhanced); hippocampal formation: 56.9444% (minimum 75%, Missing); hypothalamus: 61.1940% (minimum 75%, Missing); kidney: 57.7465% (minimum 60%, Enhanced); liver: 53.9474% (minimum 60%, Enhanced); midbrain: 54.6667% (minimum 75%, Missing); pituitary gland: 64.0625% (minimum 75%, Missing); retina: 1.3175% (minimum 75%, Missing); spinal cord: 52.5641% (minimum 75%, Missing)",0.123585,0.0592593,-0.736825,0,1,partial,307.1,1.9,2.3,"retina: 307.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129535,NRL,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 53.2468% (minimum 75%, Missing); basal ganglia: 52.5641% (minimum 75%, Missing); cerebral cortex: 55.4054% (minimum 60%, Enhanced); hippocampal formation: 56.9444% (minimum 75%, Missing); hypothalamus: 61.1940% (minimum 75%, Missing); kidney: 57.7465% (minimum 60%, Enhanced); liver: 53.9474% (minimum 60%, Enhanced); midbrain: 54.6667% (minimum 75%, Missing); pituitary gland: 64.0625% (minimum 75%, Missing); retina: 1.3175% (minimum 75%, Missing); spinal cord: 52.5641% (minimum 75%, Missing)",0.123585,0.0592593,-0.736825,0,1,partial,307.1,1.9,2.3,"retina: 307.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129535,NRL,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 53.2468% (minimum 75%, Missing); basal ganglia: 52.5641% (minimum 75%, Missing); cerebral cortex: 55.4054% (minimum 60%, Enhanced); hippocampal formation: 56.9444% (minimum 75%, Missing); hypothalamus: 61.1940% (minimum 75%, Missing); kidney: 57.7465% (minimum 60%, Enhanced); liver: 53.9474% (minimum 60%, Enhanced); midbrain: 54.6667% (minimum 75%, Missing); pituitary gland: 64.0625% (minimum 75%, Missing); retina: 1.3175% (minimum 75%, Missing); spinal cord: 52.5641% (minimum 75%, Missing)",0.123585,0.0592593,-0.736825,0,1,partial,307.1,1.9,2.3,"retina: 307.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129535,NRL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.0769% (minimum 75%, Baseline (adaptation disabled)); amygdala: 53.2468% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 52.5641% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 69.4915% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 55.4054% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.6897% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 56.9444% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.1940% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.7465% (minimum 75%, Baseline (adaptation disabled)); liver: 53.9474% (minimum 75%, Baseline (adaptation disabled)); midbrain: 54.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.9298% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 68.3333% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 64.0625% (minimum 75%, Baseline (adaptation disabled)); retina: 1.3175% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 66.1290% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 52.5641% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 64.0625% (minimum 65%, Baseline (adaptation disabled))",-0.009375,-0.0166667,-0.736825,0,1,partial,307.1,1.9,2.3,"retina: 307.1 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129535,NRL,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.2442% (minimum 95%, Missing); adrenal gland: 41.2385% (minimum 99%, Missing); amygdala: 38.9527% (minimum 99%, Missing); basal ganglia: 37.5154% (minimum 99%, Missing); bone marrow: 62.9385% (minimum 99%, Missing); cerebellum: 50.5302% (minimum 99%, Missing); cerebral cortex: 34.7301% (minimum 99%, Missing); choroid plexus: 46.4231% (minimum 99%, Missing); colon: 47.7159% (minimum 97%, Missing); duodenum: 73.7784% (minimum 99%, Missing); esophagus: 43.7088% (minimum 97%, Missing); heart muscle: 34.4477% (minimum 99%, Missing); hippocampal formation: 42.5502% (minimum 99%, Missing); hypothalamus: 40.9726% (minimum 99%, Missing); kidney: 44.4736% (minimum 99%, Missing); liver: 47.0970% (minimum 99%, Missing); lung: 51.5725% (minimum 99%, Missing); lymph node: 65.8463% (minimum 97%, Missing); midbrain: 41.3503% (minimum 99%, Missing); pancreas: 58.6088% (minimum 99%, Missing); parathyroid gland: 35.3582% (minimum 97%, Missing); pituitary gland: 52.1189% (minimum 99%, Missing); rectum: 64.0218% (minimum 97%, Missing); retina: 67.8683% (minimum 99%, Missing); salivary gland: 53.0250% (minimum 97%, Missing); skeletal muscle: 34.9450% (minimum 99%, Missing); skin: 46.3808% (minimum 95%, Missing); small intestine: 54.9154% (minimum 99%, Missing); smooth muscle: 61.8661% (minimum 99%, Missing); spinal cord: 47.5819% (minimum 99%, Missing); spleen: 48.7065% (minimum 95%, Missing); stomach: 51.7124% (minimum 97%, Missing); thymus: 55.4949% (minimum 95%, Missing); thyroid gland: 54.2126% (minimum 95%, Missing); tongue: 44.6167% (minimum 97%, Missing); urinary bladder: 50.9182% (minimum 97%, Missing)",-0.486192,-0.616418,-0.645523,0,0,routine_complete,290.2,278.8,176.3,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 2); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 2); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 2); skin: 176.3 nTPM (manageable, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 2); adipose tissue: 163.6 nTPM (manageable, limit 5); spleen: 160.6 nTPM (manageable, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 2); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 2); pituitary gland: 140.1 nTPM (vital, limit 1); salivary gland: 135.1 nTPM (protected, limit 2); thyroid gland: 128.8 nTPM (manageable, limit 5); small intestine: 125.2 nTPM (vital, limit 1); thymus: 122.3 nTPM (manageable, limit 5); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 2); lymph node: 79.1 nTPM (protected, limit 2); retina: 72.2 nTPM (vital, limit 1); duodenum: 54.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129559,NEDD8,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.2442% (minimum 65%, Missing); adrenal gland: 41.2385% (minimum 75%, Missing); amygdala: 38.9527% (minimum 75%, Missing); basal ganglia: 37.5154% (minimum 75%, Missing); bone marrow: 62.9385% (minimum 75%, Missing); cerebellum: 50.5302% (minimum 75%, Missing); cerebral cortex: 34.7301% (minimum 75%, Missing); choroid plexus: 46.4231% (minimum 75%, Missing); colon: 47.7159% (minimum 70%, Missing); duodenum: 73.7784% (minimum 75%, Missing); esophagus: 43.7088% (minimum 70%, Missing); heart muscle: 34.4477% (minimum 75%, Missing); hippocampal formation: 42.5502% (minimum 75%, Missing); hypothalamus: 40.9726% (minimum 75%, Missing); kidney: 44.4736% (minimum 75%, Missing); liver: 47.0970% (minimum 75%, Missing); lung: 51.5725% (minimum 75%, Missing); lymph node: 65.8463% (minimum 70%, Missing); midbrain: 41.3503% (minimum 75%, Missing); pancreas: 58.6088% (minimum 75%, Missing); parathyroid gland: 35.3582% (minimum 70%, Missing); pituitary gland: 52.1189% (minimum 75%, Missing); rectum: 64.0218% (minimum 70%, Missing); retina: 67.8683% (minimum 75%, Missing); salivary gland: 53.0250% (minimum 70%, Missing); skeletal muscle: 34.9450% (minimum 75%, Missing); skin: 46.3808% (minimum 65%, Missing); small intestine: 54.9154% (minimum 75%, Missing); smooth muscle: 61.8661% (minimum 75%, Missing); spinal cord: 47.5819% (minimum 75%, Missing); spleen: 48.7065% (minimum 65%, Missing); stomach: 51.7124% (minimum 70%, Missing); thymus: 55.4949% (minimum 65%, Missing); thyroid gland: 54.2126% (minimum 65%, Missing); tongue: 44.6167% (minimum 70%, Missing); urinary bladder: 50.9182% (minimum 70%, Missing)",-0.186192,-0.346418,-0.405523,0,0,routine_complete,290.2,278.8,176.3,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 2); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 2); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 2); skin: 176.3 nTPM (manageable, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 2); adipose tissue: 163.6 nTPM (manageable, limit 5); spleen: 160.6 nTPM (manageable, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 2); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 2); pituitary gland: 140.1 nTPM (vital, limit 1); salivary gland: 135.1 nTPM (protected, limit 2); thyroid gland: 128.8 nTPM (manageable, limit 5); small intestine: 125.2 nTPM (vital, limit 1); thymus: 122.3 nTPM (manageable, limit 5); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 2); lymph node: 79.1 nTPM (protected, limit 2); retina: 72.2 nTPM (vital, limit 1); duodenum: 54.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129559,NEDD8,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.2442% (minimum 65%, Missing); adrenal gland: 41.2385% (minimum 75%, Missing); amygdala: 38.9527% (minimum 75%, Missing); basal ganglia: 37.5154% (minimum 75%, Missing); bone marrow: 62.9385% (minimum 75%, Missing); cerebellum: 50.5302% (minimum 75%, Missing); cerebral cortex: 34.7301% (minimum 75%, Missing); choroid plexus: 46.4231% (minimum 75%, Missing); colon: 47.7159% (minimum 70%, Missing); duodenum: 73.7784% (minimum 75%, Missing); esophagus: 43.7088% (minimum 70%, Missing); heart muscle: 34.4477% (minimum 75%, Missing); hippocampal formation: 42.5502% (minimum 75%, Missing); hypothalamus: 40.9726% (minimum 75%, Missing); kidney: 44.4736% (minimum 75%, Missing); liver: 47.0970% (minimum 75%, Missing); lung: 51.5725% (minimum 75%, Missing); lymph node: 65.8463% (minimum 70%, Missing); midbrain: 41.3503% (minimum 75%, Missing); pancreas: 58.6088% (minimum 75%, Missing); parathyroid gland: 35.3582% (minimum 70%, Missing); pituitary gland: 52.1189% (minimum 75%, Missing); rectum: 64.0218% (minimum 70%, Missing); retina: 67.8683% (minimum 75%, Missing); salivary gland: 53.0250% (minimum 70%, Missing); skeletal muscle: 34.9450% (minimum 75%, Missing); skin: 46.3808% (minimum 65%, Missing); small intestine: 54.9154% (minimum 75%, Missing); smooth muscle: 61.8661% (minimum 75%, Missing); spinal cord: 47.5819% (minimum 75%, Missing); spleen: 48.7065% (minimum 65%, Missing); stomach: 51.7124% (minimum 70%, Missing); thymus: 55.4949% (minimum 65%, Missing); thyroid gland: 54.2126% (minimum 65%, Missing); tongue: 44.6167% (minimum 70%, Missing); urinary bladder: 50.9182% (minimum 70%, Missing)",-0.186192,-0.346418,-0.405523,0,0,routine_complete,290.2,278.8,176.3,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 3); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 3); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 3); skin: 176.3 nTPM (manageable, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 3); adipose tissue: 163.6 nTPM (manageable, limit 5); spleen: 160.6 nTPM (manageable, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 3); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 3); pituitary gland: 140.1 nTPM (vital, limit 1); salivary gland: 135.1 nTPM (protected, limit 3); thyroid gland: 128.8 nTPM (manageable, limit 5); small intestine: 125.2 nTPM (vital, limit 1); thymus: 122.3 nTPM (manageable, limit 5); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 3); lymph node: 79.1 nTPM (protected, limit 3); retina: 72.2 nTPM (vital, limit 1); duodenum: 54.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129559,NEDD8,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.2442% (minimum 65%, Missing); adrenal gland: 41.2385% (minimum 75%, Missing); amygdala: 38.9527% (minimum 75%, Missing); basal ganglia: 37.5154% (minimum 75%, Missing); bone marrow: 62.9385% (minimum 75%, Missing); cerebellum: 50.5302% (minimum 75%, Missing); cerebral cortex: 34.7301% (minimum 75%, Missing); choroid plexus: 46.4231% (minimum 75%, Missing); colon: 47.7159% (minimum 70%, Missing); duodenum: 73.7784% (minimum 75%, Missing); esophagus: 43.7088% (minimum 70%, Missing); heart muscle: 34.4477% (minimum 75%, Missing); hippocampal formation: 42.5502% (minimum 75%, Missing); hypothalamus: 40.9726% (minimum 75%, Missing); kidney: 44.4736% (minimum 75%, Missing); liver: 47.0970% (minimum 75%, Missing); lung: 51.5725% (minimum 75%, Missing); lymph node: 65.8463% (minimum 70%, Missing); midbrain: 41.3503% (minimum 75%, Missing); pancreas: 58.6088% (minimum 75%, Missing); parathyroid gland: 35.3582% (minimum 70%, Missing); pituitary gland: 52.1189% (minimum 75%, Missing); rectum: 64.0218% (minimum 70%, Missing); retina: 67.8683% (minimum 75%, Missing); salivary gland: 53.0250% (minimum 70%, Missing); skeletal muscle: 34.9450% (minimum 75%, Missing); skin: 46.3808% (minimum 65%, Missing); small intestine: 54.9154% (minimum 75%, Missing); smooth muscle: 61.8661% (minimum 75%, Missing); spinal cord: 47.5819% (minimum 75%, Missing); spleen: 48.7065% (minimum 65%, Missing); stomach: 51.7124% (minimum 70%, Missing); thymus: 55.4949% (minimum 65%, Missing); thyroid gland: 54.2126% (minimum 65%, Missing); tongue: 44.6167% (minimum 70%, Missing); urinary bladder: 50.9182% (minimum 70%, Missing)",-0.186192,-0.346418,-0.405523,0,0,routine_complete,290.2,278.8,176.3,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 3); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 3); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 3); skin: 176.3 nTPM (manageable, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 3); adipose tissue: 163.6 nTPM (manageable, limit 5); spleen: 160.6 nTPM (manageable, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 3); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 3); pituitary gland: 140.1 nTPM (vital, limit 1); salivary gland: 135.1 nTPM (protected, limit 3); thyroid gland: 128.8 nTPM (manageable, limit 5); small intestine: 125.2 nTPM (vital, limit 1); thymus: 122.3 nTPM (manageable, limit 5); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 3); lymph node: 79.1 nTPM (protected, limit 3); retina: 72.2 nTPM (vital, limit 1); duodenum: 54.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129559,NEDD8,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.2442% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 41.2385% (minimum 75%, Baseline (adaptation disabled)); amygdala: 38.9527% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 37.5154% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 62.9385% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 50.5302% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 34.7301% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 46.4231% (minimum 75%, Baseline (adaptation disabled)); colon: 47.7159% (minimum 70%, Baseline (adaptation disabled)); duodenum: 73.7784% (minimum 75%, Baseline (adaptation disabled)); esophagus: 43.7088% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 34.4477% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 42.5502% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 40.9726% (minimum 75%, Baseline (adaptation disabled)); kidney: 44.4736% (minimum 75%, Baseline (adaptation disabled)); liver: 47.0970% (minimum 75%, Baseline (adaptation disabled)); lung: 51.5725% (minimum 75%, Baseline (adaptation disabled)); lymph node: 65.8463% (minimum 70%, Baseline (adaptation disabled)); midbrain: 41.3503% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.6088% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 35.3582% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 52.1189% (minimum 75%, Baseline (adaptation disabled)); rectum: 64.0218% (minimum 70%, Baseline (adaptation disabled)); retina: 67.8683% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.0250% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 34.9450% (minimum 75%, Baseline (adaptation disabled)); skin: 46.3808% (minimum 65%, Baseline (adaptation disabled)); small intestine: 54.9154% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.8661% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 47.5819% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.7065% (minimum 65%, Baseline (adaptation disabled)); stomach: 51.7124% (minimum 70%, Baseline (adaptation disabled)); thymus: 55.4949% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.2126% (minimum 65%, Baseline (adaptation disabled)); tongue: 44.6167% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 50.9182% (minimum 70%, Baseline (adaptation disabled))",-0.186192,-0.346418,-0.405523,0,0,routine_complete,290.2,278.8,176.3,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 3); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 3); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 3); skin: 176.3 nTPM (manageable, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 3); adipose tissue: 163.6 nTPM (manageable, limit 5); spleen: 160.6 nTPM (manageable, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 3); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 3); pituitary gland: 140.1 nTPM (vital, limit 1); salivary gland: 135.1 nTPM (protected, limit 3); thyroid gland: 128.8 nTPM (manageable, limit 5); small intestine: 125.2 nTPM (vital, limit 1); thymus: 122.3 nTPM (manageable, limit 5); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 3); lymph node: 79.1 nTPM (protected, limit 3); retina: 72.2 nTPM (vital, limit 1); duodenum: 54.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129559,NEDD8,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 88.9447% (minimum 99%, Missing); basal ganglia: 84.6890% (minimum 99%, Missing); bone marrow: 90.7692% (minimum 95%, Enhanced); cerebellum: 70.8000% (minimum 95%, Enhanced); cerebral cortex: 83.8863% (minimum 95%, Enhanced); choroid plexus: 94.6524% (minimum 99%, Missing); heart muscle: 91.7098% (minimum 95%, Enhanced); hippocampal formation: 87.6238% (minimum 99%, Missing); hypothalamus: 85.0962% (minimum 99%, Missing); kidney: 90.3061% (minimum 95%, Enhanced); liver: 88.9447% (minimum 95%, Enhanced); lung: 91.2371% (minimum 95%, Enhanced); midbrain: 88.5000% (minimum 99%, Missing); pancreas: 90.7692% (minimum 95%, Enhanced); pituitary gland: 90.7692% (minimum 99%, Missing); retina: 87.1921% (minimum 99%, Missing); skeletal muscle: 93.6508% (minimum 95%, Enhanced); small intestine: 94.1489% (minimum 95%, Enhanced); spinal cord: 88.0597% (minimum 99%, Missing)",0.0225275,0.00252747,-0.242,0,2,partial,7.3,3.4,4.2,"cerebellum: 7.3 nTPM (vital, limit 6); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129646,QRICH2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308219,0.272527,0.09689,0,2,partial,7.3,3.4,4.2,"cerebellum: 7.3 nTPM (vital, limit 6); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129646,QRICH2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308219,0.272527,0.09689,0,2,partial,7.3,3.4,4.2,"cerebellum: 7.3 nTPM (vital, limit 6); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129646,QRICH2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308219,0.272527,0.09689,0,2,partial,7.3,3.4,4.2,"cerebellum: 7.3 nTPM (vital, limit 6); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129646,QRICH2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 70.8000% (minimum 75%, Baseline (adaptation disabled))",0.158219,0.138863,-0.042,0,2,partial,7.3,3.4,4.2,"cerebellum: 7.3 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129646,QRICH2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.7447% (minimum 99%, Missing); amygdala: 88.2353% (minimum 99%, Missing); basal ganglia: 91.8367% (minimum 99%, Missing); bone marrow: 78.9474% (minimum 99%, Missing); cerebellum: 88.2353% (minimum 99%, Missing); cerebral cortex: 88.2353% (minimum 99%, Missing); choroid plexus: 65.2174% (minimum 99%, Missing); duodenum: 97.8261% (minimum 99%, Missing); esophagus: 93.7500% (minimum 97%, Missing); heart muscle: 97.8261% (minimum 99%, Missing); hippocampal formation: 88.2353% (minimum 99%, Missing); hypothalamus: 86.5385% (minimum 99%, Missing); kidney: 93.7500% (minimum 99%, Missing); lung: 95.7447% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 84.9057% (minimum 99%, Missing); pancreas: 95.7447% (minimum 99%, Missing); pituitary gland: 93.7500% (minimum 99%, Missing); retina: 29.8013% (minimum 99%, Missing); skin: 77.5862% (minimum 95%, Missing); small intestine: 91.8367% (minimum 99%, Missing); spinal cord: 88.2353% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 95.7447% (minimum 97%, Missing); thyroid gland: 91.8367% (minimum 95%, Missing); urinary bladder: 95.7447% (minimum 97%, Missing)",-0.174138,-0.22,-0.691987,0,80,unavailable,10.6,1.5,1.3,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129673,AANAT,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.2174% (minimum 75%, Missing); retina: 29.8013% (minimum 75%, Missing)",0.125862,0.05,-0.451987,0,80,unavailable,10.6,1.5,1.3,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129673,AANAT,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.2174% (minimum 75%, Missing); retina: 29.8013% (minimum 75%, Missing)",0.125862,0.05,-0.451987,0,80,unavailable,10.6,1.5,1.3,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129673,AANAT,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.2174% (minimum 75%, Missing); retina: 29.8013% (minimum 75%, Missing)",0.125862,0.05,-0.451987,0,80,unavailable,10.6,1.5,1.3,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129673,AANAT,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.2174% (minimum 75%, Baseline (adaptation disabled)); retina: 29.8013% (minimum 75%, Baseline (adaptation disabled))",0.125862,0.05,-0.451987,0,80,unavailable,10.6,1.5,1.3,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129673,AANAT,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 43.0464% (minimum 95%, Enhanced); colon: 76.4706% (minimum 97%, Missing); duodenum: 74.7126% (minimum 99%, Missing); esophagus: 77.3810% (minimum 97%, Missing); liver: 91.5493% (minimum 95%, Enhanced); lymph node: 51.5873% (minimum 97%, Missing); rectum: 70.6522% (minimum 97%, Missing); retina: 98.4848% (minimum 99%, Missing); skin: 85.5263% (minimum 95%, Missing); small intestine: 73.0337% (minimum 99%, Missing); smooth muscle: 87.8378% (minimum 95%, Enhanced); spinal cord: 98.4848% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 82.2785% (minimum 97%, Missing); thymus: 34.0314% (minimum 95%, Missing); urinary bladder: 87.8378% (minimum 97%, Missing)",-0.609686,-0.454127,-0.519536,0,9,partial,8.6,6.1,12.6,"thymus: 12.6 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 6); lymph node: 6.1 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; appendix / germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129810,SGO1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 43.0464% (minimum 60%, Enhanced); duodenum: 74.7126% (minimum 75%, Missing); lymph node: 51.5873% (minimum 70%, Missing); small intestine: 73.0337% (minimum 75%, Missing); thymus: 34.0314% (minimum 65%, Missing)",-0.309686,-0.184127,-0.169536,0,9,partial,8.6,6.1,12.6,"thymus: 12.6 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 6); lymph node: 6.1 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; appendix / germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129810,SGO1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 43.0464% (minimum 60%, Enhanced); duodenum: 74.7126% (minimum 75%, Missing); lymph node: 51.5873% (minimum 70%, Missing); small intestine: 73.0337% (minimum 75%, Missing); thymus: 34.0314% (minimum 65%, Missing)",-0.309686,-0.184127,-0.169536,0,9,partial,8.6,6.1,12.6,"thymus: 12.6 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 6); lymph node: 6.1 nTPM (protected, limit 3); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; appendix / germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129810,SGO1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 43.0464% (minimum 60%, Enhanced); duodenum: 74.7126% (minimum 75%, Missing); lymph node: 51.5873% (minimum 70%, Missing); small intestine: 73.0337% (minimum 75%, Missing); thymus: 34.0314% (minimum 65%, Missing)",-0.309686,-0.184127,-0.169536,0,9,partial,8.6,6.1,12.6,"thymus: 12.6 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 6); lymph node: 6.1 nTPM (protected, limit 3); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; appendix / germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129810,SGO1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 43.0464% (minimum 75%, Baseline (adaptation disabled)); duodenum: 74.7126% (minimum 75%, Baseline (adaptation disabled)); lymph node: 51.5873% (minimum 70%, Baseline (adaptation disabled)); small intestine: 73.0337% (minimum 75%, Baseline (adaptation disabled)); thymus: 34.0314% (minimum 65%, Baseline (adaptation disabled))",-0.309686,-0.184127,-0.319536,0,9,partial,8.6,6.1,12.6,"thymus: 12.6 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 3); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; appendix / germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129810,SGO1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129862,VCY1B,admission_only,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129862,VCY1B,selectivity_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129862,VCY1B,grid_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129862,VCY1B,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129862,VCY1B,current_fixed,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,7,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129864,VCY,admission_only,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,7,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129864,VCY,selectivity_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,7,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129864,VCY,grid_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,7,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129864,VCY,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,7,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129864,VCY,current_fixed,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129873,CDY2B,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129873,CDY2B,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129873,CDY2B,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129873,CDY2B,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000129873,CDY2B,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.00543726,0,3,partial,5.1,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130167,TSPAN16,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.245437,0,3,partial,5.1,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130167,TSPAN16,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.245437,0,3,partial,5.1,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130167,TSPAN16,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.245437,0,3,partial,5.1,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130167,TSPAN16,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.348474,0.299237,0.2125,0,3,partial,5.1,0.1,0.2,"bone marrow: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130167,TSPAN16,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 89.9814% (minimum 99%, Missing); colon: 83.4768% (minimum 97%, Missing); duodenum: 21.3000% (minimum 99%, Missing); heart muscle: 54.0089% (minimum 95%, Enhanced); kidney: 36.2752% (minimum 99%, Missing); liver: 89.6488% (minimum 95%, Enhanced); pancreas: 95.2849% (minimum 99%, Missing); rectum: 89.3186% (minimum 97%, Missing); small intestine: 16.9344% (minimum 99%, Missing)",0.0397959,-0.135232,-0.820656,0,12,partial,237.9,9.6,8.6,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); heart muscle: 41.3 nTPM (vital, limit 6); colon: 9.6 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); choroid plexus: 5.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130234,ACE2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 21.3000% (minimum 75%, Missing); heart muscle: 54.0089% (minimum 60%, Enhanced); kidney: 36.2752% (minimum 75%, Missing); small intestine: 16.9344% (minimum 75%, Missing)",0.339796,0.134768,-0.580656,0,12,partial,237.9,9.6,8.6,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); heart muscle: 41.3 nTPM (vital, limit 6); colon: 9.6 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); choroid plexus: 5.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130234,ACE2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 21.3000% (minimum 75%, Missing); heart muscle: 54.0089% (minimum 60%, Enhanced); kidney: 36.2752% (minimum 75%, Missing); small intestine: 16.9344% (minimum 75%, Missing)",0.339796,0.134768,-0.580656,0,12,partial,237.9,9.6,8.6,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); heart muscle: 41.3 nTPM (vital, limit 6); colon: 9.6 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); choroid plexus: 5.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130234,ACE2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 21.3000% (minimum 75%, Missing); heart muscle: 54.0089% (minimum 60%, Enhanced); kidney: 36.2752% (minimum 75%, Missing); small intestine: 16.9344% (minimum 75%, Missing)",0.339796,0.134768,-0.580656,0,12,partial,237.9,9.6,8.6,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); heart muscle: 41.3 nTPM (vital, limit 6); colon: 9.6 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); choroid plexus: 5.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130234,ACE2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 21.3000% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 54.0089% (minimum 75%, Baseline (adaptation disabled)); kidney: 36.2752% (minimum 75%, Baseline (adaptation disabled)); small intestine: 16.9344% (minimum 75%, Baseline (adaptation disabled))",0.199387,0.134768,-0.580656,0,12,partial,237.9,9.6,8.6,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); heart muscle: 41.3 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 3); adipose tissue: 8.6 nTPM (manageable, limit 5); rectum: 5.8 nTPM (protected, limit 3); liver: 5.6 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130234,ACE2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.8103% (minimum 99%, Missing); bone marrow: 78.5978% (minimum 99%, Missing); choroid plexus: 98.1567% (minimum 99%, Missing); duodenum: 98.6111% (minimum 99%, Missing); liver: 97.2603% (minimum 99%, Missing); lung: 97.7064% (minimum 99%, Missing); lymph node: 96.8182% (minimum 97%, Missing); pituitary gland: 98.6111% (minimum 99%, Missing); retina: 98.1567% (minimum 99%, Missing); small intestine: 98.1567% (minimum 99%, Missing); smooth muscle: 96.8182% (minimum 99%, Missing); spleen: 86.9388% (minimum 95%, Missing); thymus: 90.6383% (minimum 95%, Missing)",-0.0806122,-0.00181818,-0.204022,0,80,unavailable,5.8,0.7,3.2,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130270,ATP8B3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.219388,0.268182,0.0359779,0,80,unavailable,5.8,0.7,3.2,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130270,ATP8B3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.219388,0.268182,0.0359779,0,80,unavailable,5.8,0.7,3.2,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130270,ATP8B3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.219388,0.268182,0.0359779,0,80,unavailable,5.8,0.7,3.2,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130270,ATP8B3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.219388,0.268182,0.0359779,0,80,unavailable,5.8,0.7,3.2,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130270,ATP8B3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.00682288,0,1,partial,0.5,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130377,ACSBG2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246823,0,1,partial,0.5,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130377,ACSBG2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246823,0,1,partial,0.5,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130377,ACSBG2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246823,0,1,partial,0.5,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130377,ACSBG2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348409,0.299204,0.246032,0,1,partial,0.5,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130377,ACSBG2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 99%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing)",0.05,-0.303333,-0.704286,0,80,unavailable,0.5,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130383,FUT5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,-0.464286,0,80,unavailable,0.5,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130383,FUT5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,-0.464286,0,80,unavailable,0.5,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130383,FUT5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,-0.464286,0,80,unavailable,0.5,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130383,FUT5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 75%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.0333333,-0.464286,0,80,unavailable,0.5,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130383,FUT5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000130385,BMP15,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000130385,BMP15,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000130385,BMP15,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000130385,BMP15,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000130385,BMP15,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.9170% (minimum 99%, Missing); basal ganglia: 98.2079% (minimum 99%, Missing); bone marrow: 91.6388% (minimum 95%, Enhanced); cerebellum: 93.8356% (minimum 99%, Missing); choroid plexus: 88.9610% (minimum 99%, Missing); hippocampal formation: 98.9170% (minimum 99%, Missing); hypothalamus: 97.8571% (minimum 99%, Missing); lung: 93.8356% (minimum 95%, Enhanced); pituitary gland: 93.5154% (minimum 99%, Missing); retina: 93.1973% (minimum 99%, Missing); spinal cord: 98.9170% (minimum 99%, Missing)",0.0181979,0.03,-0.10039,0,9,partial,3.4,1.1,2.4,"choroid plexus: 3.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130518,IQCN,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.318198,0.3,0.13961,0,9,partial,3.4,1.1,2.4,"choroid plexus: 3.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130518,IQCN,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.318198,0.3,0.13961,0,9,partial,3.4,1.1,2.4,"choroid plexus: 3.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130518,IQCN,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.318198,0.3,0.13961,0,9,partial,3.4,1.1,2.4,"choroid plexus: 3.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130518,IQCN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.269463,0.261404,0.13961,0,9,partial,3.4,1.1,2.4,"choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130518,IQCN,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.3333% (minimum 95%, Missing); adrenal gland: 52.5000% (minimum 99%, Missing); amygdala: 67.7419% (minimum 99%, Missing); basal ganglia: 65.6250% (minimum 99%, Missing); bone marrow: 36.2069% (minimum 99%, Missing); cerebellum: 51.2195% (minimum 99%, Missing); cerebral cortex: 53.8462% (minimum 99%, Missing); choroid plexus: 72.4138% (minimum 99%, Missing); colon: 58.3333% (minimum 97%, Missing); duodenum: 65.6250% (minimum 99%, Missing); esophagus: 55.2632% (minimum 97%, Missing); heart muscle: 63.6364% (minimum 99%, Missing); hippocampal formation: 63.6364% (minimum 99%, Missing); hypothalamus: 65.6250% (minimum 99%, Missing); kidney: 55.2632% (minimum 99%, Missing); liver: 50.0000% (minimum 99%, Missing); lung: 61.7647% (minimum 99%, Missing); lymph node: 45.6522% (minimum 97%, Missing); midbrain: 67.7419% (minimum 99%, Missing); pancreas: 55.2632% (minimum 99%, Missing); parathyroid gland: 55.2632% (minimum 97%, Missing); pituitary gland: 58.3333% (minimum 99%, Missing); rectum: 61.7647% (minimum 97%, Missing); retina: 55.2632% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 97%, Missing); skeletal muscle: 61.7647% (minimum 99%, Missing); skin: 52.5000% (minimum 95%, Missing); small intestine: 56.7568% (minimum 99%, Missing); smooth muscle: 58.3333% (minimum 99%, Missing); spinal cord: 63.6364% (minimum 99%, Missing); spleen: 47.7273% (minimum 95%, Missing); stomach: 55.2632% (minimum 97%, Missing); thymus: 47.7273% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 67.7419% (minimum 97%, Missing); urinary bladder: 58.3333% (minimum 97%, Missing)",-0.472727,-0.513478,-0.627931,0,80,unavailable,3.7,2.5,2.3,"bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130544,ZNF557,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.3333% (minimum 65%, Missing); adrenal gland: 52.5000% (minimum 75%, Missing); amygdala: 67.7419% (minimum 75%, Missing); basal ganglia: 65.6250% (minimum 75%, Missing); bone marrow: 36.2069% (minimum 75%, Missing); cerebellum: 51.2195% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); choroid plexus: 72.4138% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); esophagus: 55.2632% (minimum 70%, Missing); heart muscle: 63.6364% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 65.6250% (minimum 75%, Missing); kidney: 55.2632% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Missing); lung: 61.7647% (minimum 75%, Missing); lymph node: 45.6522% (minimum 70%, Missing); midbrain: 67.7419% (minimum 75%, Missing); pancreas: 55.2632% (minimum 75%, Missing); parathyroid gland: 55.2632% (minimum 70%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); rectum: 61.7647% (minimum 70%, Missing); retina: 55.2632% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 61.7647% (minimum 75%, Missing); skin: 52.5000% (minimum 65%, Missing); small intestine: 56.7568% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 75%, Missing); spinal cord: 63.6364% (minimum 75%, Missing); spleen: 47.7273% (minimum 65%, Missing); stomach: 55.2632% (minimum 70%, Missing); thymus: 47.7273% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 67.7419% (minimum 70%, Missing); urinary bladder: 58.3333% (minimum 70%, Missing)",-0.172727,-0.243478,-0.387931,0,80,unavailable,3.7,2.5,2.3,"bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130544,ZNF557,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.3333% (minimum 65%, Missing); adrenal gland: 52.5000% (minimum 75%, Missing); amygdala: 67.7419% (minimum 75%, Missing); basal ganglia: 65.6250% (minimum 75%, Missing); bone marrow: 36.2069% (minimum 75%, Missing); cerebellum: 51.2195% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); choroid plexus: 72.4138% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); esophagus: 55.2632% (minimum 70%, Missing); heart muscle: 63.6364% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 65.6250% (minimum 75%, Missing); kidney: 55.2632% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Missing); lung: 61.7647% (minimum 75%, Missing); lymph node: 45.6522% (minimum 70%, Missing); midbrain: 67.7419% (minimum 75%, Missing); pancreas: 55.2632% (minimum 75%, Missing); parathyroid gland: 55.2632% (minimum 70%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); rectum: 61.7647% (minimum 70%, Missing); retina: 55.2632% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 61.7647% (minimum 75%, Missing); skin: 52.5000% (minimum 65%, Missing); small intestine: 56.7568% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 75%, Missing); spinal cord: 63.6364% (minimum 75%, Missing); spleen: 47.7273% (minimum 65%, Missing); stomach: 55.2632% (minimum 70%, Missing); thymus: 47.7273% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 67.7419% (minimum 70%, Missing); urinary bladder: 58.3333% (minimum 70%, Missing)",-0.172727,-0.243478,-0.387931,0,80,unavailable,3.7,2.5,2.3,"bone marrow: 3.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130544,ZNF557,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.3333% (minimum 65%, Missing); adrenal gland: 52.5000% (minimum 75%, Missing); amygdala: 67.7419% (minimum 75%, Missing); basal ganglia: 65.6250% (minimum 75%, Missing); bone marrow: 36.2069% (minimum 75%, Missing); cerebellum: 51.2195% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); choroid plexus: 72.4138% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); esophagus: 55.2632% (minimum 70%, Missing); heart muscle: 63.6364% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 65.6250% (minimum 75%, Missing); kidney: 55.2632% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Missing); lung: 61.7647% (minimum 75%, Missing); lymph node: 45.6522% (minimum 70%, Missing); midbrain: 67.7419% (minimum 75%, Missing); pancreas: 55.2632% (minimum 75%, Missing); parathyroid gland: 55.2632% (minimum 70%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); rectum: 61.7647% (minimum 70%, Missing); retina: 55.2632% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 61.7647% (minimum 75%, Missing); skin: 52.5000% (minimum 65%, Missing); small intestine: 56.7568% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 75%, Missing); spinal cord: 63.6364% (minimum 75%, Missing); spleen: 47.7273% (minimum 65%, Missing); stomach: 55.2632% (minimum 70%, Missing); thymus: 47.7273% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 67.7419% (minimum 70%, Missing); urinary bladder: 58.3333% (minimum 70%, Missing)",-0.172727,-0.243478,-0.387931,0,80,unavailable,3.7,2.5,2.3,"bone marrow: 3.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130544,ZNF557,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.3333% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 52.5000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 67.7419% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.6250% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 36.2069% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 51.2195% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.8462% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.4138% (minimum 75%, Baseline (adaptation disabled)); colon: 58.3333% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.6250% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.2632% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.6364% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.6364% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.6250% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.2632% (minimum 75%, Baseline (adaptation disabled)); liver: 50.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 61.7647% (minimum 75%, Baseline (adaptation disabled)); lymph node: 45.6522% (minimum 70%, Baseline (adaptation disabled)); midbrain: 67.7419% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.2632% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.2632% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.3333% (minimum 75%, Baseline (adaptation disabled)); rectum: 61.7647% (minimum 70%, Baseline (adaptation disabled)); retina: 55.2632% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 61.7647% (minimum 75%, Baseline (adaptation disabled)); skin: 52.5000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.7568% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.6364% (minimum 75%, Baseline (adaptation disabled)); spleen: 47.7273% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.2632% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.7273% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.7419% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.3333% (minimum 70%, Baseline (adaptation disabled))",-0.172727,-0.243478,-0.387931,0,80,unavailable,3.7,2.5,2.3,"bone marrow: 3.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130544,ZNF557,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.7742% (minimum 99%, Missing); basal ganglia: 44.7761% (minimum 99%, Missing); hypothalamus: 96.7742% (minimum 99%, Missing); midbrain: 96.7742% (minimum 99%, Missing); retina: 0.2106% (minimum 99%, Missing)",0.05,0.03,-0.987894,0,5,partial,1421.5,0,0.1,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),57,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130561,SAG,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 44.7761% (minimum 75%, Missing); retina: 0.2106% (minimum 75%, Missing)",0.35,0.3,-0.747894,0,5,partial,1421.5,0,0.1,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),57,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130561,SAG,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 44.7761% (minimum 75%, Missing); retina: 0.2106% (minimum 75%, Missing)",0.35,0.3,-0.747894,0,5,partial,1421.5,0,0.1,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),57,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130561,SAG,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 44.7761% (minimum 75%, Missing); retina: 0.2106% (minimum 75%, Missing)",0.35,0.3,-0.747894,0,5,partial,1421.5,0,0.1,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),57,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130561,SAG,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 44.7761% (minimum 75%, Baseline (adaptation disabled)); retina: 0.2106% (minimum 75%, Baseline (adaptation disabled))",0.317742,0.3,-0.747894,0,5,partial,1421.5,0,0.1,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),57,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130561,SAG,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.0256% (minimum 99%, Missing); basal ganglia: 94.6667% (minimum 99%, Missing); bone marrow: 64.5455% (minimum 99%, Missing); cerebellum: 94.6667% (minimum 98%, Approved); cerebral cortex: 93.4211% (minimum 98%, Approved); choroid plexus: 84.5238% (minimum 99%, Missing); heart muscle: 97.2603% (minimum 98%, Approved); hippocampal formation: 93.4211% (minimum 99%, Missing); hypothalamus: 95.9459% (minimum 99%, Missing); liver: 97.2603% (minimum 98%, Approved); lung: 93.4211% (minimum 98%, Approved); midbrain: 97.2603% (minimum 99%, Missing); pituitary gland: 98.6111% (minimum 99%, Missing); spinal cord: 97.2603% (minimum 99%, Missing)",0.00945946,0.0226027,-0.344545,0,2,partial,3.9,0.2,0.6,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; spleen / cells in red pulp,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130656,HBZ,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 64.5455% (minimum 75%, Missing)",0.309459,0.3,-0.104545,0,2,partial,3.9,0.2,0.6,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; spleen / cells in red pulp,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130656,HBZ,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 64.5455% (minimum 75%, Missing)",0.309459,0.3,-0.104545,0,2,partial,3.9,0.2,0.6,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; spleen / cells in red pulp,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130656,HBZ,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 64.5455% (minimum 75%, Missing)",0.309459,0.3,-0.104545,0,2,partial,3.9,0.2,0.6,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; spleen / cells in red pulp,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130656,HBZ,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 64.5455% (minimum 75%, Baseline (adaptation disabled))",0.272078,0.272603,-0.104545,0,2,partial,3.9,0.2,0.6,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; spleen / cells in red pulp,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130656,HBZ,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.9827% (minimum 99%, Missing)",0.0470674,0.0256076,-0.0101729,0,2,partial,1.4,0.3,0.5,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130783,CCDC62,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347067,0.295608,0.229827,0,2,partial,1.4,0.3,0.5,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130783,CCDC62,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347067,0.295608,0.229827,0,2,partial,1.4,0.3,0.5,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130783,CCDC62,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347067,0.295608,0.229827,0,2,partial,1.4,0.3,0.5,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130783,CCDC62,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342701,0.295608,0.229827,0,2,partial,1.4,0.3,0.5,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130783,CCDC62,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.9340% (minimum 95%, Missing); adrenal gland: 50.1259% (minimum 99%, Missing); amygdala: 62.3824% (minimum 99%, Missing); basal ganglia: 60.6707% (minimum 99%, Missing); bone marrow: 63.3758% (minimum 99%, Missing); cerebellum: 54.0761% (minimum 99%, Missing); cerebral cortex: 57.0201% (minimum 99%, Missing); choroid plexus: 59.2262% (minimum 99%, Missing); colon: 52.3684% (minimum 97%, Missing); duodenum: 62.7760% (minimum 99%, Missing); esophagus: 42.4307% (minimum 97%, Missing); heart muscle: 53.7838% (minimum 99%, Missing); hippocampal formation: 60.4863% (minimum 99%, Missing); hypothalamus: 62.7760% (minimum 99%, Missing); kidney: 52.0942% (minimum 99%, Missing); liver: 45.4338% (minimum 99%, Missing); lung: 58.0175% (minimum 99%, Missing); lymph node: 53.6388% (minimum 97%, Missing); midbrain: 64.6104% (minimum 99%, Missing); pancreas: 46.9340% (minimum 99%, Missing); parathyroid gland: 71.3262% (minimum 97%, Missing); pituitary gland: 59.7598% (minimum 99%, Missing); rectum: 79.9197% (minimum 97%, Missing); retina: 82.2314% (minimum 99%, Missing); salivary gland: 55.1247% (minimum 97%, Missing); skeletal muscle: 38.6408% (minimum 99%, Missing); skin: 42.1610% (minimum 95%, Missing); small intestine: 50.6361% (minimum 99%, Missing); smooth muscle: 75.6654% (minimum 99%, Missing); spinal cord: 65.2459% (minimum 99%, Missing); spleen: 43.4498% (minimum 95%, Missing); stomach: 52.7851% (minimum 97%, Missing); thymus: 67.4576% (minimum 95%, Missing); thyroid gland: 56.2147% (minimum 95%, Missing); tongue: 65.6766% (minimum 97%, Missing); urinary bladder: 50.1259% (minimum 97%, Missing)",-0.52839,-0.545693,-0.603592,0,3,partial,31.6,27,27.3,"skeletal muscle: 31.6 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 27 nTPM (protected, limit 2); spleen: 25.9 nTPM (manageable, limit 5); liver: 23.9 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); pancreas: 22.5 nTPM (vital, limit 1); adrenal gland: 19.8 nTPM (vital, limit 1); urinary bladder: 19.8 nTPM (protected, limit 2); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 2); stomach: 17.8 nTPM (protected, limit 2); lymph node: 17.2 nTPM (protected, limit 2); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); salivary gland: 16.2 nTPM (protected, limit 2); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 2); thymus: 9.6 nTPM (manageable, limit 5); parathyroid gland: 8 nTPM (protected, limit 2); smooth muscle: 6.4 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130810,PPAN,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.9340% (minimum 65%, Missing); adrenal gland: 50.1259% (minimum 75%, Missing); amygdala: 62.3824% (minimum 75%, Missing); basal ganglia: 60.6707% (minimum 75%, Missing); bone marrow: 63.3758% (minimum 75%, Missing); cerebellum: 54.0761% (minimum 75%, Missing); cerebral cortex: 57.0201% (minimum 75%, Missing); choroid plexus: 59.2262% (minimum 75%, Missing); colon: 52.3684% (minimum 70%, Missing); duodenum: 62.7760% (minimum 75%, Missing); esophagus: 42.4307% (minimum 70%, Missing); heart muscle: 53.7838% (minimum 75%, Missing); hippocampal formation: 60.4863% (minimum 75%, Missing); hypothalamus: 62.7760% (minimum 75%, Missing); kidney: 52.0942% (minimum 75%, Missing); liver: 45.4338% (minimum 75%, Missing); lung: 58.0175% (minimum 75%, Missing); lymph node: 53.6388% (minimum 70%, Missing); midbrain: 64.6104% (minimum 75%, Missing); pancreas: 46.9340% (minimum 75%, Missing); pituitary gland: 59.7598% (minimum 75%, Missing); salivary gland: 55.1247% (minimum 70%, Missing); skeletal muscle: 38.6408% (minimum 75%, Missing); skin: 42.1610% (minimum 65%, Missing); small intestine: 50.6361% (minimum 75%, Missing); spinal cord: 65.2459% (minimum 75%, Missing); spleen: 43.4498% (minimum 65%, Missing); stomach: 52.7851% (minimum 70%, Missing); thyroid gland: 56.2147% (minimum 65%, Missing); tongue: 65.6766% (minimum 70%, Missing); urinary bladder: 50.1259% (minimum 70%, Missing)",-0.22839,-0.275693,-0.363592,0,3,partial,31.6,27,27.3,"skeletal muscle: 31.6 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 27 nTPM (protected, limit 2); spleen: 25.9 nTPM (manageable, limit 5); liver: 23.9 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); pancreas: 22.5 nTPM (vital, limit 1); adrenal gland: 19.8 nTPM (vital, limit 1); urinary bladder: 19.8 nTPM (protected, limit 2); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 2); stomach: 17.8 nTPM (protected, limit 2); lymph node: 17.2 nTPM (protected, limit 2); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); salivary gland: 16.2 nTPM (protected, limit 2); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 2); thymus: 9.6 nTPM (manageable, limit 5); parathyroid gland: 8 nTPM (protected, limit 2); smooth muscle: 6.4 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130810,PPAN,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.9340% (minimum 65%, Missing); adrenal gland: 50.1259% (minimum 75%, Missing); amygdala: 62.3824% (minimum 75%, Missing); basal ganglia: 60.6707% (minimum 75%, Missing); bone marrow: 63.3758% (minimum 75%, Missing); cerebellum: 54.0761% (minimum 75%, Missing); cerebral cortex: 57.0201% (minimum 75%, Missing); choroid plexus: 59.2262% (minimum 75%, Missing); colon: 52.3684% (minimum 70%, Missing); duodenum: 62.7760% (minimum 75%, Missing); esophagus: 42.4307% (minimum 70%, Missing); heart muscle: 53.7838% (minimum 75%, Missing); hippocampal formation: 60.4863% (minimum 75%, Missing); hypothalamus: 62.7760% (minimum 75%, Missing); kidney: 52.0942% (minimum 75%, Missing); liver: 45.4338% (minimum 75%, Missing); lung: 58.0175% (minimum 75%, Missing); lymph node: 53.6388% (minimum 70%, Missing); midbrain: 64.6104% (minimum 75%, Missing); pancreas: 46.9340% (minimum 75%, Missing); pituitary gland: 59.7598% (minimum 75%, Missing); salivary gland: 55.1247% (minimum 70%, Missing); skeletal muscle: 38.6408% (minimum 75%, Missing); skin: 42.1610% (minimum 65%, Missing); small intestine: 50.6361% (minimum 75%, Missing); spinal cord: 65.2459% (minimum 75%, Missing); spleen: 43.4498% (minimum 65%, Missing); stomach: 52.7851% (minimum 70%, Missing); thyroid gland: 56.2147% (minimum 65%, Missing); tongue: 65.6766% (minimum 70%, Missing); urinary bladder: 50.1259% (minimum 70%, Missing)",-0.22839,-0.275693,-0.363592,0,3,partial,31.6,27,27.3,"skeletal muscle: 31.6 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 27 nTPM (protected, limit 3); spleen: 25.9 nTPM (manageable, limit 5); liver: 23.9 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); pancreas: 22.5 nTPM (vital, limit 1); adrenal gland: 19.8 nTPM (vital, limit 1); urinary bladder: 19.8 nTPM (protected, limit 3); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 3); stomach: 17.8 nTPM (protected, limit 3); lymph node: 17.2 nTPM (protected, limit 3); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); salivary gland: 16.2 nTPM (protected, limit 3); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 3); thymus: 9.6 nTPM (manageable, limit 5); parathyroid gland: 8 nTPM (protected, limit 3); smooth muscle: 6.4 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130810,PPAN,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.9340% (minimum 65%, Missing); adrenal gland: 50.1259% (minimum 75%, Missing); amygdala: 62.3824% (minimum 75%, Missing); basal ganglia: 60.6707% (minimum 75%, Missing); bone marrow: 63.3758% (minimum 75%, Missing); cerebellum: 54.0761% (minimum 75%, Missing); cerebral cortex: 57.0201% (minimum 75%, Missing); choroid plexus: 59.2262% (minimum 75%, Missing); colon: 52.3684% (minimum 70%, Missing); duodenum: 62.7760% (minimum 75%, Missing); esophagus: 42.4307% (minimum 70%, Missing); heart muscle: 53.7838% (minimum 75%, Missing); hippocampal formation: 60.4863% (minimum 75%, Missing); hypothalamus: 62.7760% (minimum 75%, Missing); kidney: 52.0942% (minimum 75%, Missing); liver: 45.4338% (minimum 75%, Missing); lung: 58.0175% (minimum 75%, Missing); lymph node: 53.6388% (minimum 70%, Missing); midbrain: 64.6104% (minimum 75%, Missing); pancreas: 46.9340% (minimum 75%, Missing); pituitary gland: 59.7598% (minimum 75%, Missing); salivary gland: 55.1247% (minimum 70%, Missing); skeletal muscle: 38.6408% (minimum 75%, Missing); skin: 42.1610% (minimum 65%, Missing); small intestine: 50.6361% (minimum 75%, Missing); spinal cord: 65.2459% (minimum 75%, Missing); spleen: 43.4498% (minimum 65%, Missing); stomach: 52.7851% (minimum 70%, Missing); thyroid gland: 56.2147% (minimum 65%, Missing); tongue: 65.6766% (minimum 70%, Missing); urinary bladder: 50.1259% (minimum 70%, Missing)",-0.22839,-0.275693,-0.363592,0,3,partial,31.6,27,27.3,"skeletal muscle: 31.6 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 27 nTPM (protected, limit 3); spleen: 25.9 nTPM (manageable, limit 5); liver: 23.9 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); pancreas: 22.5 nTPM (vital, limit 1); adrenal gland: 19.8 nTPM (vital, limit 1); urinary bladder: 19.8 nTPM (protected, limit 3); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 3); stomach: 17.8 nTPM (protected, limit 3); lymph node: 17.2 nTPM (protected, limit 3); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); salivary gland: 16.2 nTPM (protected, limit 3); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 3); thymus: 9.6 nTPM (manageable, limit 5); parathyroid gland: 8 nTPM (protected, limit 3); smooth muscle: 6.4 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130810,PPAN,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.9340% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 50.1259% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.3824% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.6707% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 63.3758% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.0761% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.0201% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 59.2262% (minimum 75%, Baseline (adaptation disabled)); colon: 52.3684% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.7760% (minimum 75%, Baseline (adaptation disabled)); esophagus: 42.4307% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 53.7838% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 60.4863% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.7760% (minimum 75%, Baseline (adaptation disabled)); kidney: 52.0942% (minimum 75%, Baseline (adaptation disabled)); liver: 45.4338% (minimum 75%, Baseline (adaptation disabled)); lung: 58.0175% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.6388% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.6104% (minimum 75%, Baseline (adaptation disabled)); pancreas: 46.9340% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 59.7598% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.1247% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 38.6408% (minimum 75%, Baseline (adaptation disabled)); skin: 42.1610% (minimum 65%, Baseline (adaptation disabled)); small intestine: 50.6361% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.2459% (minimum 75%, Baseline (adaptation disabled)); spleen: 43.4498% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.7851% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 56.2147% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.6766% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 50.1259% (minimum 70%, Baseline (adaptation disabled))",-0.22839,-0.275693,-0.363592,0,3,partial,31.6,27,27.3,"skeletal muscle: 31.6 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 27 nTPM (protected, limit 3); spleen: 25.9 nTPM (manageable, limit 5); liver: 23.9 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); pancreas: 22.5 nTPM (vital, limit 1); adrenal gland: 19.8 nTPM (vital, limit 1); urinary bladder: 19.8 nTPM (protected, limit 3); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 3); stomach: 17.8 nTPM (protected, limit 3); lymph node: 17.2 nTPM (protected, limit 3); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); salivary gland: 16.2 nTPM (protected, limit 3); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 3); thymus: 9.6 nTPM (manageable, limit 5); parathyroid gland: 8 nTPM (protected, limit 3); smooth muscle: 6.4 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130810,PPAN,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 97.0588% (minimum 99%, Missing); duodenum: 94.2857% (minimum 95%, Enhanced); heart muscle: 91.6667% (minimum 95%, Enhanced); pancreas: 94.2857% (minimum 95%, Enhanced); pituitary gland: 97.0588% (minimum 99%, Missing); retina: 94.2857% (minimum 99%, Missing); small intestine: 94.2857% (minimum 95%, Enhanced); spinal cord: 97.0588% (minimum 99%, Missing)",0.05,0.000588235,-0.0471429,0,5,partial,0.3,0.1,0.5,,,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130943,PKDREJ,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.270588,0.192857,0,5,partial,0.3,0.1,0.5,,,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130943,PKDREJ,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.270588,0.192857,0,5,partial,0.3,0.1,0.5,,,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130943,PKDREJ,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.270588,0.192857,0,5,partial,0.3,0.1,0.5,,,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130943,PKDREJ,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.218421,0.270588,0.166667,0,5,partial,0.3,0.1,0.5,,,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130943,PKDREJ,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 92.7273% (minimum 99%, Missing); basal ganglia: 91.7738% (minimum 99%, Missing); cerebral cortex: 93.7008% (minimum 95%, Enhanced); choroid plexus: 98.8920% (minimum 99%, Missing); heart muscle: 94.4444% (minimum 95%, Enhanced); hippocampal formation: 89.6985% (minimum 99%, Missing); hypothalamus: 94.1953% (minimum 99%, Missing); kidney: 88.5856% (minimum 95%, Enhanced); liver: 70.6931% (minimum 95%, Enhanced); midbrain: 89.4737% (minimum 99%, Missing); pancreas: 89.9244% (minimum 95%, Enhanced); pituitary gland: 95.4545% (minimum 99%, Missing); retina: 98.0769% (minimum 99%, Missing); small intestine: 90.8397% (minimum 95%, Enhanced); spinal cord: 87.7150% (minimum 99%, Missing)",0.05,0.0272067,-0.243069,0,1,partial,14.8,2.6,9.7,"liver: 14.8 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130948,HSD17B3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.286344,0.297207,0.106931,0,1,partial,14.8,2.6,9.7,"liver: 14.8 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130948,HSD17B3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.286344,0.297207,0.106931,0,1,partial,14.8,2.6,9.7,"liver: 14.8 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130948,HSD17B3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.286344,0.297207,0.106931,0,1,partial,14.8,2.6,9.7,"liver: 14.8 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130948,HSD17B3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 70.6931% (minimum 75%, Baseline (adaptation disabled))",0.136344,0.232115,-0.0430693,0,1,partial,14.8,2.6,9.7,"liver: 14.8 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); spinal cord: 5 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130948,HSD17B3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 94.7368% (minimum 99%, Missing); liver: 94.7368% (minimum 99%, Missing)",0.05,0.03,-0.0426316,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130950,NUTM2F,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.197368,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130950,NUTM2F,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.197368,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130950,NUTM2F,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.197368,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130950,NUTM2F,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.197368,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000130950,NUTM2F,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.5616% (minimum 90%, Approved); adrenal gland: 83.5616% (minimum 98%, Approved); amygdala: 95.3125% (minimum 99%, Missing); basal ganglia: 95.3125% (minimum 99%, Missing); bone marrow: 89.7059% (minimum 99%, Missing); cerebral cortex: 88.4058% (minimum 98%, Approved); choroid plexus: 87.1429% (minimum 99%, Missing); colon: 88.4058% (minimum 95%, Approved); duodenum: 85.9155% (minimum 98%, Approved); esophagus: 80.2632% (minimum 97%, Missing); heart muscle: 89.7059% (minimum 98%, Approved); hippocampal formation: 95.3125% (minimum 99%, Missing); hypothalamus: 91.0448% (minimum 99%, Missing); kidney: 79.2208% (minimum 98%, Approved); liver: 87.1429% (minimum 98%, Approved); lung: 81.3333% (minimum 98%, Approved); lymph node: 92.4242% (minimum 97%, Missing); midbrain: 98.3871% (minimum 99%, Missing); pancreas: 91.0448% (minimum 98%, Approved); parathyroid gland: 87.1429% (minimum 95%, Approved); pituitary gland: 98.3871% (minimum 99%, Missing); rectum: 89.7059% (minimum 97%, Missing); retina: 89.7059% (minimum 99%, Missing); salivary gland: 93.8462% (minimum 95%, Approved); skeletal muscle: 49.1935% (minimum 98%, Approved); skin: 85.9155% (minimum 95%, Missing); small intestine: 92.4242% (minimum 98%, Approved); smooth muscle: 92.4242% (minimum 98%, Approved); spinal cord: 98.3871% (minimum 99%, Missing); spleen: 91.0448% (minimum 95%, Missing); stomach: 77.2152% (minimum 97%, Missing); thymus: 92.4242% (minimum 95%, Missing); thyroid gland: 55.9633% (minimum 90%, Approved); tongue: 93.8462% (minimum 97%, Missing); urinary bladder: 85.9155% (minimum 95%, Approved)",-0.340367,-0.197848,-0.488065,0,2,partial,6.3,1.8,4.8,"skeletal muscle: 6.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131019,ULBP3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skeletal muscle: 49.1935% (minimum 70%, Approved); thyroid gland: 55.9633% (minimum 60%, Approved)",-0.040367,0.0721519,-0.208065,0,2,partial,6.3,1.8,4.8,"skeletal muscle: 6.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131019,ULBP3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skeletal muscle: 49.1935% (minimum 70%, Approved); thyroid gland: 55.9633% (minimum 60%, Approved)",-0.040367,0.0721519,-0.208065,0,2,partial,6.3,1.8,4.8,"skeletal muscle: 6.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131019,ULBP3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skeletal muscle: 49.1935% (minimum 70%, Approved); thyroid gland: 55.9633% (minimum 60%, Approved)",-0.040367,0.0721519,-0.208065,0,2,partial,6.3,1.8,4.8,"skeletal muscle: 6.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131019,ULBP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skeletal muscle: 49.1935% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 55.9633% (minimum 65%, Baseline (adaptation disabled))",-0.090367,0.0721519,-0.258065,0,2,partial,6.3,1.8,4.8,"skeletal muscle: 6.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131019,ULBP3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.3607% (minimum 99%, Missing); amygdala: 76.9231% (minimum 99%, Missing); basal ganglia: 68.9655% (minimum 99%, Missing); cerebellum: 88.2353% (minimum 99%, Missing); cerebral cortex: 84.5070% (minimum 99%, Missing); choroid plexus: 28.5714% (minimum 99%, Missing); hippocampal formation: 70.5882% (minimum 99%, Missing); hypothalamus: 69.7674% (minimum 99%, Missing); kidney: 89.5522% (minimum 99%, Missing); lung: 84.5070% (minimum 99%, Missing); midbrain: 75.9494% (minimum 99%, Missing); pancreas: 96.7742% (minimum 99%, Missing); parathyroid gland: 90.9091% (minimum 97%, Missing); pituitary gland: 86.9565% (minimum 99%, Missing); retina: 93.7500% (minimum 99%, Missing); small intestine: 98.3607% (minimum 99%, Missing); spinal cord: 72.2892% (minimum 99%, Missing); thyroid gland: 90.9091% (minimum 95%, Missing)",-0.0409091,-0.0609091,-0.704286,0,80,unavailable,15,0.6,0.6,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131044,TTLL9,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 68.9655% (minimum 75%, Missing); choroid plexus: 28.5714% (minimum 75%, Missing); hippocampal formation: 70.5882% (minimum 75%, Missing); hypothalamus: 69.7674% (minimum 75%, Missing); spinal cord: 72.2892% (minimum 75%, Missing)",0.259091,0.209091,-0.464286,0,80,unavailable,15,0.6,0.6,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131044,TTLL9,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 68.9655% (minimum 75%, Missing); choroid plexus: 28.5714% (minimum 75%, Missing); hippocampal formation: 70.5882% (minimum 75%, Missing); hypothalamus: 69.7674% (minimum 75%, Missing); spinal cord: 72.2892% (minimum 75%, Missing)",0.259091,0.209091,-0.464286,0,80,unavailable,15,0.6,0.6,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131044,TTLL9,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 68.9655% (minimum 75%, Missing); choroid plexus: 28.5714% (minimum 75%, Missing); hippocampal formation: 70.5882% (minimum 75%, Missing); hypothalamus: 69.7674% (minimum 75%, Missing); spinal cord: 72.2892% (minimum 75%, Missing)",0.259091,0.209091,-0.464286,0,80,unavailable,15,0.6,0.6,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131044,TTLL9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 68.9655% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 28.5714% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.5882% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.7674% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.2892% (minimum 75%, Baseline (adaptation disabled))",0.259091,0.209091,-0.464286,0,80,unavailable,15,0.6,0.6,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131044,TTLL9,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 91.1111% (minimum 95%, Enhanced); heart muscle: 82.0000% (minimum 95%, Enhanced); hippocampal formation: 97.6190% (minimum 99%, Missing); kidney: 93.1818% (minimum 95%, Enhanced); pancreas: 51.8987% (minimum 95%, Enhanced); salivary gland: 0.0615% (minimum 97%, Missing)",0.05,-0.969385,-0.431013,0,5,partial,3.8,6665.1,0.3,"salivary gland: 6665.1 nTPM (protected, limit 2)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; salivary gland / glandular cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131050,BPIFA2,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 51.8987% (minimum 60%, Enhanced); salivary gland: 0.0615% (minimum 70%, Missing)",0.35,-0.699385,-0.0810127,0,5,partial,3.8,6665.1,0.3,"salivary gland: 6665.1 nTPM (protected, limit 2)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; salivary gland / glandular cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131050,BPIFA2,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 51.8987% (minimum 60%, Enhanced); salivary gland: 0.0615% (minimum 70%, Missing)",0.35,-0.699385,-0.0810127,0,5,partial,3.8,6665.1,0.3,"salivary gland: 6665.1 nTPM (protected, limit 3)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; salivary gland / glandular cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131050,BPIFA2,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 51.8987% (minimum 60%, Enhanced); salivary gland: 0.0615% (minimum 70%, Missing)",0.35,-0.699385,-0.0810127,0,5,partial,3.8,6665.1,0.3,"salivary gland: 6665.1 nTPM (protected, limit 3)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; salivary gland / glandular cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131050,BPIFA2,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 51.8987% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 0.0615% (minimum 70%, Baseline (adaptation disabled))",0.281818,-0.699385,-0.231013,0,5,partial,3.8,6665.1,0.3,"salivary gland: 6665.1 nTPM (protected, limit 3); pancreas: 3.8 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; salivary gland / glandular cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131050,BPIFA2,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131059,BPIFA3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131059,BPIFA3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131059,BPIFA3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131059,BPIFA3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131059,BPIFA3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000131068,DEFB118,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000131068,DEFB118,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000131068,DEFB118,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000131068,DEFB118,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000131068,DEFB118,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.2530% (minimum 95%, Uncertain); adrenal gland: 61.0465% (minimum 99%, Uncertain); amygdala: 60.3448% (minimum 99%, Missing); basal ganglia: 61.7647% (minimum 99%, Missing); bone marrow: 68.1818% (minimum 99%, Missing); cerebellum: 51.7241% (minimum 99%, Missing); cerebral cortex: 61.4035% (minimum 99%, Missing); choroid plexus: 66.4557% (minimum 99%, Missing); colon: 61.0465% (minimum 97%, Missing); duodenum: 66.4557% (minimum 99%, Missing); esophagus: 62.1302% (minimum 97%, Missing); heart muscle: 65.6250% (minimum 99%, Missing); hippocampal formation: 60.6936% (minimum 99%, Missing); hypothalamus: 61.0465% (minimum 99%, Missing); kidney: 61.0465% (minimum 99%, Missing); liver: 59.3220% (minimum 99%, Missing); lung: 64.0244% (minimum 99%, Missing); lymph node: 50.9709% (minimum 97%, Uncertain); midbrain: 57.6923% (minimum 99%, Missing); pancreas: 62.1302% (minimum 99%, Missing); parathyroid gland: 51.2195% (minimum 97%, Missing); pituitary gland: 57.3770% (minimum 99%, Missing); rectum: 65.2174% (minimum 97%, Missing); retina: 55.2632% (minimum 99%, Missing); salivary gland: 66.0377% (minimum 97%, Missing); skeletal muscle: 62.8743% (minimum 99%, Uncertain); skin: 62.5000% (minimum 95%, Missing); small intestine: 65.2174% (minimum 99%, Missing); smooth muscle: 61.7647% (minimum 99%, Uncertain); spinal cord: 56.1497% (minimum 99%, Missing); spleen: 53.2995% (minimum 95%, Missing); stomach: 55.5556% (minimum 97%, Missing); thymus: 38.6029% (minimum 95%, Missing); thyroid gland: 56.7568% (minimum 95%, Missing); tongue: 62.8743% (minimum 97%, Missing); urinary bladder: 60.3448% (minimum 97%, Missing)",-0.563971,-0.460291,-0.472759,0,1,partial,9.8,10.1,16.7,"thymus: 16.7 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 2); parathyroid gland: 10 nTPM (protected, limit 2); cerebellum: 9.8 nTPM (vital, limit 1); spleen: 9.2 nTPM (manageable, limit 5); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 2); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); kidney: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); pancreas: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 2); skeletal muscle: 6.2 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); lung: 5.9 nTPM (vital, limit 1); small intestine: 5.6 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 2); heart muscle: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); choroid plexus: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131115,ZNF227,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.2530% (minimum 65%, Uncertain); adrenal gland: 61.0465% (minimum 75%, Uncertain); amygdala: 60.3448% (minimum 75%, Missing); basal ganglia: 61.7647% (minimum 75%, Missing); bone marrow: 68.1818% (minimum 75%, Missing); cerebellum: 51.7241% (minimum 75%, Missing); cerebral cortex: 61.4035% (minimum 75%, Missing); choroid plexus: 66.4557% (minimum 75%, Missing); colon: 61.0465% (minimum 70%, Missing); duodenum: 66.4557% (minimum 75%, Missing); esophagus: 62.1302% (minimum 70%, Missing); heart muscle: 65.6250% (minimum 75%, Missing); hippocampal formation: 60.6936% (minimum 75%, Missing); hypothalamus: 61.0465% (minimum 75%, Missing); kidney: 61.0465% (minimum 75%, Missing); liver: 59.3220% (minimum 75%, Missing); lung: 64.0244% (minimum 75%, Missing); lymph node: 50.9709% (minimum 70%, Uncertain); midbrain: 57.6923% (minimum 75%, Missing); pancreas: 62.1302% (minimum 75%, Missing); parathyroid gland: 51.2195% (minimum 70%, Missing); pituitary gland: 57.3770% (minimum 75%, Missing); rectum: 65.2174% (minimum 70%, Missing); retina: 55.2632% (minimum 75%, Missing); salivary gland: 66.0377% (minimum 70%, Missing); skeletal muscle: 62.8743% (minimum 75%, Uncertain); skin: 62.5000% (minimum 65%, Missing); small intestine: 65.2174% (minimum 75%, Missing); smooth muscle: 61.7647% (minimum 75%, Uncertain); spinal cord: 56.1497% (minimum 75%, Missing); spleen: 53.2995% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 38.6029% (minimum 65%, Missing); thyroid gland: 56.7568% (minimum 65%, Missing); tongue: 62.8743% (minimum 70%, Missing); urinary bladder: 60.3448% (minimum 70%, Missing)",-0.263971,-0.190291,-0.232759,0,1,partial,9.8,10.1,16.7,"thymus: 16.7 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 2); parathyroid gland: 10 nTPM (protected, limit 2); cerebellum: 9.8 nTPM (vital, limit 1); spleen: 9.2 nTPM (manageable, limit 5); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 2); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); kidney: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); pancreas: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 2); skeletal muscle: 6.2 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); lung: 5.9 nTPM (vital, limit 1); small intestine: 5.6 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 2); heart muscle: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); choroid plexus: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131115,ZNF227,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.2530% (minimum 65%, Uncertain); adrenal gland: 61.0465% (minimum 75%, Uncertain); amygdala: 60.3448% (minimum 75%, Missing); basal ganglia: 61.7647% (minimum 75%, Missing); bone marrow: 68.1818% (minimum 75%, Missing); cerebellum: 51.7241% (minimum 75%, Missing); cerebral cortex: 61.4035% (minimum 75%, Missing); choroid plexus: 66.4557% (minimum 75%, Missing); colon: 61.0465% (minimum 70%, Missing); duodenum: 66.4557% (minimum 75%, Missing); esophagus: 62.1302% (minimum 70%, Missing); heart muscle: 65.6250% (minimum 75%, Missing); hippocampal formation: 60.6936% (minimum 75%, Missing); hypothalamus: 61.0465% (minimum 75%, Missing); kidney: 61.0465% (minimum 75%, Missing); liver: 59.3220% (minimum 75%, Missing); lung: 64.0244% (minimum 75%, Missing); lymph node: 50.9709% (minimum 70%, Uncertain); midbrain: 57.6923% (minimum 75%, Missing); pancreas: 62.1302% (minimum 75%, Missing); parathyroid gland: 51.2195% (minimum 70%, Missing); pituitary gland: 57.3770% (minimum 75%, Missing); rectum: 65.2174% (minimum 70%, Missing); retina: 55.2632% (minimum 75%, Missing); salivary gland: 66.0377% (minimum 70%, Missing); skeletal muscle: 62.8743% (minimum 75%, Uncertain); skin: 62.5000% (minimum 65%, Missing); small intestine: 65.2174% (minimum 75%, Missing); smooth muscle: 61.7647% (minimum 75%, Uncertain); spinal cord: 56.1497% (minimum 75%, Missing); spleen: 53.2995% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 38.6029% (minimum 65%, Missing); thyroid gland: 56.7568% (minimum 65%, Missing); tongue: 62.8743% (minimum 70%, Missing); urinary bladder: 60.3448% (minimum 70%, Missing)",-0.263971,-0.190291,-0.232759,0,1,partial,9.8,10.1,16.7,"thymus: 16.7 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 3); parathyroid gland: 10 nTPM (protected, limit 3); cerebellum: 9.8 nTPM (vital, limit 1); spleen: 9.2 nTPM (manageable, limit 5); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 3); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 3); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); kidney: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); pancreas: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 3); skeletal muscle: 6.2 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); lung: 5.9 nTPM (vital, limit 1); small intestine: 5.6 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 3); heart muscle: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); choroid plexus: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131115,ZNF227,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.2530% (minimum 65%, Uncertain); adrenal gland: 61.0465% (minimum 75%, Uncertain); amygdala: 60.3448% (minimum 75%, Missing); basal ganglia: 61.7647% (minimum 75%, Missing); bone marrow: 68.1818% (minimum 75%, Missing); cerebellum: 51.7241% (minimum 75%, Missing); cerebral cortex: 61.4035% (minimum 75%, Missing); choroid plexus: 66.4557% (minimum 75%, Missing); colon: 61.0465% (minimum 70%, Missing); duodenum: 66.4557% (minimum 75%, Missing); esophagus: 62.1302% (minimum 70%, Missing); heart muscle: 65.6250% (minimum 75%, Missing); hippocampal formation: 60.6936% (minimum 75%, Missing); hypothalamus: 61.0465% (minimum 75%, Missing); kidney: 61.0465% (minimum 75%, Missing); liver: 59.3220% (minimum 75%, Missing); lung: 64.0244% (minimum 75%, Missing); lymph node: 50.9709% (minimum 70%, Uncertain); midbrain: 57.6923% (minimum 75%, Missing); pancreas: 62.1302% (minimum 75%, Missing); parathyroid gland: 51.2195% (minimum 70%, Missing); pituitary gland: 57.3770% (minimum 75%, Missing); rectum: 65.2174% (minimum 70%, Missing); retina: 55.2632% (minimum 75%, Missing); salivary gland: 66.0377% (minimum 70%, Missing); skeletal muscle: 62.8743% (minimum 75%, Uncertain); skin: 62.5000% (minimum 65%, Missing); small intestine: 65.2174% (minimum 75%, Missing); smooth muscle: 61.7647% (minimum 75%, Uncertain); spinal cord: 56.1497% (minimum 75%, Missing); spleen: 53.2995% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 38.6029% (minimum 65%, Missing); thyroid gland: 56.7568% (minimum 65%, Missing); tongue: 62.8743% (minimum 70%, Missing); urinary bladder: 60.3448% (minimum 70%, Missing)",-0.263971,-0.190291,-0.232759,0,1,partial,9.8,10.1,16.7,"thymus: 16.7 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 3); parathyroid gland: 10 nTPM (protected, limit 3); cerebellum: 9.8 nTPM (vital, limit 1); spleen: 9.2 nTPM (manageable, limit 5); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 3); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 3); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); kidney: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); pancreas: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 3); skeletal muscle: 6.2 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); lung: 5.9 nTPM (vital, limit 1); small intestine: 5.6 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 3); heart muscle: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); choroid plexus: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131115,ZNF227,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.2530% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 61.0465% (minimum 75%, Baseline (adaptation disabled)); amygdala: 60.3448% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.7647% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 68.1818% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 51.7241% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.4035% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.4557% (minimum 75%, Baseline (adaptation disabled)); colon: 61.0465% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.4557% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.1302% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.6250% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 60.6936% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.0465% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.0465% (minimum 75%, Baseline (adaptation disabled)); liver: 59.3220% (minimum 75%, Baseline (adaptation disabled)); lung: 64.0244% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.9709% (minimum 70%, Baseline (adaptation disabled)); midbrain: 57.6923% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.1302% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.2195% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 57.3770% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.2174% (minimum 70%, Baseline (adaptation disabled)); retina: 55.2632% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.0377% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 62.8743% (minimum 75%, Baseline (adaptation disabled)); skin: 62.5000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 65.2174% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.7647% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.1497% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.2995% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.5556% (minimum 70%, Baseline (adaptation disabled)); thymus: 38.6029% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.7568% (minimum 65%, Baseline (adaptation disabled)); tongue: 62.8743% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.3448% (minimum 70%, Baseline (adaptation disabled))",-0.263971,-0.190291,-0.232759,0,1,partial,9.8,10.1,16.7,"thymus: 16.7 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 3); parathyroid gland: 10 nTPM (protected, limit 3); cerebellum: 9.8 nTPM (vital, limit 1); spleen: 9.2 nTPM (manageable, limit 5); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 3); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 3); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); kidney: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); pancreas: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 3); skeletal muscle: 6.2 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); lung: 5.9 nTPM (vital, limit 1); small intestine: 5.6 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 3); heart muscle: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); choroid plexus: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131115,ZNF227,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0413345,0.0282548,0.01,0,6,partial,1.5,1.2,1.5,,,49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131126,TEX101,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.341334,0.298255,0.25,0,6,partial,1.5,1.2,1.5,,,49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131126,TEX101,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.341334,0.298255,0.25,0,6,partial,1.5,1.2,1.5,,,49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131126,TEX101,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.341334,0.298255,0.25,0,6,partial,1.5,1.2,1.5,,,49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131126,TEX101,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.337058,0.289619,0.237058,0,6,partial,1.5,1.2,1.5,"pancreas: 1.5 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131126,TEX101,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 95.5224% (minimum 99%, Missing); cerebral cortex: 98.4615% (minimum 99%, Missing); duodenum: 98.4615% (minimum 99%, Missing); kidney: 98.4615% (minimum 99%, Missing); liver: 98.4615% (minimum 99%, Missing); lymph node: 96.9697% (minimum 97%, Missing); pancreas: 98.4615% (minimum 99%, Missing); retina: 94.1176% (minimum 99%, Missing)",0.0346154,-0.00030303,-0.0488235,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131379,C3orf20,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.334615,0.269697,0.191176,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131379,C3orf20,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.334615,0.269697,0.191176,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131379,C3orf20,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.334615,0.269697,0.191176,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131379,C3orf20,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.334615,0.269697,0.191176,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131379,C3orf20,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.3585% (minimum 95%, Missing); adrenal gland: 38.4615% (minimum 99%, Missing); amygdala: 38.3474% (minimum 99%, Missing); basal ganglia: 39.3002% (minimum 99%, Missing); bone marrow: 45.0320% (minimum 99%, Missing); cerebellum: 53.0459% (minimum 99%, Missing); cerebral cortex: 40.1139% (minimum 99%, Missing); choroid plexus: 24.3099% (minimum 99%, Missing); colon: 49.7752% (minimum 97%, Missing); duodenum: 46.9697% (minimum 99%, Missing); esophagus: 52.0484% (minimum 97%, Missing); heart muscle: 28.8533% (minimum 99%, Missing); hippocampal formation: 42.8177% (minimum 99%, Missing); hypothalamus: 41.7790% (minimum 99%, Missing); kidney: 35.4691% (minimum 99%, Missing); liver: 35.3881% (minimum 99%, Missing); lung: 59.9845% (minimum 99%, Missing); lymph node: 54.6159% (minimum 97%, Missing); midbrain: 38.4234% (minimum 99%, Missing); pancreas: 49.5524% (minimum 99%, Missing); parathyroid gland: 44.6172% (minimum 97%, Missing); pituitary gland: 50.1618% (minimum 99%, Missing); rectum: 56.7766% (minimum 97%, Missing); retina: 60.6891% (minimum 99%, Missing); salivary gland: 43.9093% (minimum 97%, Missing); skeletal muscle: 22.0484% (minimum 99%, Missing); skin: 60.4524% (minimum 95%, Missing); small intestine: 48.1068% (minimum 99%, Missing); smooth muscle: 71.8258% (minimum 99%, Missing); spinal cord: 44.8755% (minimum 99%, Missing); spleen: 52.2237% (minimum 95%, Missing); stomach: 46.7713% (minimum 97%, Missing); thymus: 50.4886% (minimum 95%, Missing); thyroid gland: 55.4760% (minimum 95%, Missing); tongue: 25.7561% (minimum 97%, Missing); urinary bladder: 59.2055% (minimum 97%, Missing)",-0.445114,-0.712439,-0.769516,0,6,partial,274,223.4,76,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 2); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); salivary gland: 99 nTPM (protected, limit 2); parathyroid gland: 96.2 nTPM (protected, limit 2); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 2); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 2); pituitary gland: 77 nTPM (vital, limit 1); thymus: 76 nTPM (manageable, limit 5); adipose tissue: 73.4 nTPM (manageable, limit 5); esophagus: 71.4 nTPM (protected, limit 2); spleen: 70.9 nTPM (manageable, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 2); thyroid gland: 62.2 nTPM (manageable, limit 5); rectum: 59 nTPM (protected, limit 2); urinary bladder: 53.4 nTPM (protected, limit 2); lung: 51.7 nTPM (vital, limit 1); skin: 50.7 nTPM (manageable, limit 5); retina: 50.2 nTPM (vital, limit 1); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131495,NDUFA2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.3585% (minimum 65%, Missing); adrenal gland: 38.4615% (minimum 75%, Missing); amygdala: 38.3474% (minimum 75%, Missing); basal ganglia: 39.3002% (minimum 75%, Missing); bone marrow: 45.0320% (minimum 75%, Missing); cerebellum: 53.0459% (minimum 75%, Missing); cerebral cortex: 40.1139% (minimum 75%, Missing); choroid plexus: 24.3099% (minimum 75%, Missing); colon: 49.7752% (minimum 70%, Missing); duodenum: 46.9697% (minimum 75%, Missing); esophagus: 52.0484% (minimum 70%, Missing); heart muscle: 28.8533% (minimum 75%, Missing); hippocampal formation: 42.8177% (minimum 75%, Missing); hypothalamus: 41.7790% (minimum 75%, Missing); kidney: 35.4691% (minimum 75%, Missing); liver: 35.3881% (minimum 75%, Missing); lung: 59.9845% (minimum 75%, Missing); lymph node: 54.6159% (minimum 70%, Missing); midbrain: 38.4234% (minimum 75%, Missing); pancreas: 49.5524% (minimum 75%, Missing); parathyroid gland: 44.6172% (minimum 70%, Missing); pituitary gland: 50.1618% (minimum 75%, Missing); rectum: 56.7766% (minimum 70%, Missing); retina: 60.6891% (minimum 75%, Missing); salivary gland: 43.9093% (minimum 70%, Missing); skeletal muscle: 22.0484% (minimum 75%, Missing); skin: 60.4524% (minimum 65%, Missing); small intestine: 48.1068% (minimum 75%, Missing); smooth muscle: 71.8258% (minimum 75%, Missing); spinal cord: 44.8755% (minimum 75%, Missing); spleen: 52.2237% (minimum 65%, Missing); stomach: 46.7713% (minimum 70%, Missing); thymus: 50.4886% (minimum 65%, Missing); thyroid gland: 55.4760% (minimum 65%, Missing); tongue: 25.7561% (minimum 70%, Missing); urinary bladder: 59.2055% (minimum 70%, Missing)",-0.145114,-0.442439,-0.529516,0,6,partial,274,223.4,76,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 2); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); salivary gland: 99 nTPM (protected, limit 2); parathyroid gland: 96.2 nTPM (protected, limit 2); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 2); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 2); pituitary gland: 77 nTPM (vital, limit 1); thymus: 76 nTPM (manageable, limit 5); adipose tissue: 73.4 nTPM (manageable, limit 5); esophagus: 71.4 nTPM (protected, limit 2); spleen: 70.9 nTPM (manageable, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 2); thyroid gland: 62.2 nTPM (manageable, limit 5); rectum: 59 nTPM (protected, limit 2); urinary bladder: 53.4 nTPM (protected, limit 2); lung: 51.7 nTPM (vital, limit 1); skin: 50.7 nTPM (manageable, limit 5); retina: 50.2 nTPM (vital, limit 1); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131495,NDUFA2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.3585% (minimum 65%, Missing); adrenal gland: 38.4615% (minimum 75%, Missing); amygdala: 38.3474% (minimum 75%, Missing); basal ganglia: 39.3002% (minimum 75%, Missing); bone marrow: 45.0320% (minimum 75%, Missing); cerebellum: 53.0459% (minimum 75%, Missing); cerebral cortex: 40.1139% (minimum 75%, Missing); choroid plexus: 24.3099% (minimum 75%, Missing); colon: 49.7752% (minimum 70%, Missing); duodenum: 46.9697% (minimum 75%, Missing); esophagus: 52.0484% (minimum 70%, Missing); heart muscle: 28.8533% (minimum 75%, Missing); hippocampal formation: 42.8177% (minimum 75%, Missing); hypothalamus: 41.7790% (minimum 75%, Missing); kidney: 35.4691% (minimum 75%, Missing); liver: 35.3881% (minimum 75%, Missing); lung: 59.9845% (minimum 75%, Missing); lymph node: 54.6159% (minimum 70%, Missing); midbrain: 38.4234% (minimum 75%, Missing); pancreas: 49.5524% (minimum 75%, Missing); parathyroid gland: 44.6172% (minimum 70%, Missing); pituitary gland: 50.1618% (minimum 75%, Missing); rectum: 56.7766% (minimum 70%, Missing); retina: 60.6891% (minimum 75%, Missing); salivary gland: 43.9093% (minimum 70%, Missing); skeletal muscle: 22.0484% (minimum 75%, Missing); skin: 60.4524% (minimum 65%, Missing); small intestine: 48.1068% (minimum 75%, Missing); smooth muscle: 71.8258% (minimum 75%, Missing); spinal cord: 44.8755% (minimum 75%, Missing); spleen: 52.2237% (minimum 65%, Missing); stomach: 46.7713% (minimum 70%, Missing); thymus: 50.4886% (minimum 65%, Missing); thyroid gland: 55.4760% (minimum 65%, Missing); tongue: 25.7561% (minimum 70%, Missing); urinary bladder: 59.2055% (minimum 70%, Missing)",-0.145114,-0.442439,-0.529516,0,6,partial,274,223.4,76,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 3); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); salivary gland: 99 nTPM (protected, limit 3); parathyroid gland: 96.2 nTPM (protected, limit 3); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 3); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 3); pituitary gland: 77 nTPM (vital, limit 1); thymus: 76 nTPM (manageable, limit 5); adipose tissue: 73.4 nTPM (manageable, limit 5); esophagus: 71.4 nTPM (protected, limit 3); spleen: 70.9 nTPM (manageable, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 3); thyroid gland: 62.2 nTPM (manageable, limit 5); rectum: 59 nTPM (protected, limit 3); urinary bladder: 53.4 nTPM (protected, limit 3); lung: 51.7 nTPM (vital, limit 1); skin: 50.7 nTPM (manageable, limit 5); retina: 50.2 nTPM (vital, limit 1); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131495,NDUFA2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.3585% (minimum 65%, Missing); adrenal gland: 38.4615% (minimum 75%, Missing); amygdala: 38.3474% (minimum 75%, Missing); basal ganglia: 39.3002% (minimum 75%, Missing); bone marrow: 45.0320% (minimum 75%, Missing); cerebellum: 53.0459% (minimum 75%, Missing); cerebral cortex: 40.1139% (minimum 75%, Missing); choroid plexus: 24.3099% (minimum 75%, Missing); colon: 49.7752% (minimum 70%, Missing); duodenum: 46.9697% (minimum 75%, Missing); esophagus: 52.0484% (minimum 70%, Missing); heart muscle: 28.8533% (minimum 75%, Missing); hippocampal formation: 42.8177% (minimum 75%, Missing); hypothalamus: 41.7790% (minimum 75%, Missing); kidney: 35.4691% (minimum 75%, Missing); liver: 35.3881% (minimum 75%, Missing); lung: 59.9845% (minimum 75%, Missing); lymph node: 54.6159% (minimum 70%, Missing); midbrain: 38.4234% (minimum 75%, Missing); pancreas: 49.5524% (minimum 75%, Missing); parathyroid gland: 44.6172% (minimum 70%, Missing); pituitary gland: 50.1618% (minimum 75%, Missing); rectum: 56.7766% (minimum 70%, Missing); retina: 60.6891% (minimum 75%, Missing); salivary gland: 43.9093% (minimum 70%, Missing); skeletal muscle: 22.0484% (minimum 75%, Missing); skin: 60.4524% (minimum 65%, Missing); small intestine: 48.1068% (minimum 75%, Missing); smooth muscle: 71.8258% (minimum 75%, Missing); spinal cord: 44.8755% (minimum 75%, Missing); spleen: 52.2237% (minimum 65%, Missing); stomach: 46.7713% (minimum 70%, Missing); thymus: 50.4886% (minimum 65%, Missing); thyroid gland: 55.4760% (minimum 65%, Missing); tongue: 25.7561% (minimum 70%, Missing); urinary bladder: 59.2055% (minimum 70%, Missing)",-0.145114,-0.442439,-0.529516,0,6,partial,274,223.4,76,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 3); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); salivary gland: 99 nTPM (protected, limit 3); parathyroid gland: 96.2 nTPM (protected, limit 3); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 3); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 3); pituitary gland: 77 nTPM (vital, limit 1); thymus: 76 nTPM (manageable, limit 5); adipose tissue: 73.4 nTPM (manageable, limit 5); esophagus: 71.4 nTPM (protected, limit 3); spleen: 70.9 nTPM (manageable, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 3); thyroid gland: 62.2 nTPM (manageable, limit 5); rectum: 59 nTPM (protected, limit 3); urinary bladder: 53.4 nTPM (protected, limit 3); lung: 51.7 nTPM (vital, limit 1); skin: 50.7 nTPM (manageable, limit 5); retina: 50.2 nTPM (vital, limit 1); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131495,NDUFA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.3585% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 38.4615% (minimum 75%, Baseline (adaptation disabled)); amygdala: 38.3474% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 39.3002% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 45.0320% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 53.0459% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 40.1139% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 24.3099% (minimum 75%, Baseline (adaptation disabled)); colon: 49.7752% (minimum 70%, Baseline (adaptation disabled)); duodenum: 46.9697% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.0484% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 28.8533% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 42.8177% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 41.7790% (minimum 75%, Baseline (adaptation disabled)); kidney: 35.4691% (minimum 75%, Baseline (adaptation disabled)); liver: 35.3881% (minimum 75%, Baseline (adaptation disabled)); lung: 59.9845% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.6159% (minimum 70%, Baseline (adaptation disabled)); midbrain: 38.4234% (minimum 75%, Baseline (adaptation disabled)); pancreas: 49.5524% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 44.6172% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 50.1618% (minimum 75%, Baseline (adaptation disabled)); rectum: 56.7766% (minimum 70%, Baseline (adaptation disabled)); retina: 60.6891% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 43.9093% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 22.0484% (minimum 75%, Baseline (adaptation disabled)); skin: 60.4524% (minimum 65%, Baseline (adaptation disabled)); small intestine: 48.1068% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.8258% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 44.8755% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.2237% (minimum 65%, Baseline (adaptation disabled)); stomach: 46.7713% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.4886% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.4760% (minimum 65%, Baseline (adaptation disabled)); tongue: 25.7561% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 59.2055% (minimum 70%, Baseline (adaptation disabled))",-0.145114,-0.442439,-0.529516,0,6,partial,274,223.4,76,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 3); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); salivary gland: 99 nTPM (protected, limit 3); parathyroid gland: 96.2 nTPM (protected, limit 3); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 3); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 3); pituitary gland: 77 nTPM (vital, limit 1); thymus: 76 nTPM (manageable, limit 5); adipose tissue: 73.4 nTPM (manageable, limit 5); esophagus: 71.4 nTPM (protected, limit 3); spleen: 70.9 nTPM (manageable, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 3); thyroid gland: 62.2 nTPM (manageable, limit 5); rectum: 59 nTPM (protected, limit 3); urinary bladder: 53.4 nTPM (protected, limit 3); lung: 51.7 nTPM (vital, limit 1); skin: 50.7 nTPM (manageable, limit 5); retina: 50.2 nTPM (vital, limit 1); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131495,NDUFA2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.000740741,0,1,partial,0.2,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131721,RHOXF2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240741,0,1,partial,0.2,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131721,RHOXF2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240741,0,1,partial,0.2,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131721,RHOXF2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240741,0,1,partial,0.2,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131721,RHOXF2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340741,0.3,0.231651,0,1,partial,0.2,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131721,RHOXF2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 22.2222% (minimum 80%, Supported); cerebral cortex: 33.3333% (minimum 97%, Supported); esophagus: 66.6667% (minimum 90%, Supported); hippocampal formation: 50.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 90%, Supported); skin: 0.2488% (minimum 95%, Missing); thymus: 13.3333% (minimum 95%, Missing)",-0.947512,-0.233333,-0.636667,0,6,partial,0.4,0.1,80.2,"skin: 80.2 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131738,KRT33B,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 22.2222% (minimum 55%, Supported); cerebral cortex: 33.3333% (minimum 65%, Supported); hippocampal formation: 50.0000% (minimum 75%, Missing); skin: 0.2488% (minimum 65%, Missing); thymus: 13.3333% (minimum 65%, Missing)",-0.647512,0.0666667,-0.316667,0,6,partial,0.4,0.1,80.2,"skin: 80.2 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131738,KRT33B,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 22.2222% (minimum 55%, Supported); cerebral cortex: 33.3333% (minimum 65%, Supported); hippocampal formation: 50.0000% (minimum 75%, Missing); skin: 0.2488% (minimum 65%, Missing); thymus: 13.3333% (minimum 65%, Missing)",-0.647512,0.0666667,-0.316667,0,6,partial,0.4,0.1,80.2,"skin: 80.2 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131738,KRT33B,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 22.2222% (minimum 55%, Supported); cerebral cortex: 33.3333% (minimum 65%, Supported); hippocampal formation: 50.0000% (minimum 75%, Missing); skin: 0.2488% (minimum 65%, Missing); thymus: 13.3333% (minimum 65%, Missing)",-0.647512,0.0666667,-0.316667,0,6,partial,0.4,0.1,80.2,"skin: 80.2 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131738,KRT33B,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 22.2222% (minimum 65%, Baseline (adaptation disabled)); cerebral cortex: 33.3333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); skin: 0.2488% (minimum 65%, Baseline (adaptation disabled)); thymus: 13.3333% (minimum 65%, Baseline (adaptation disabled))",-0.647512,-0.0333333,-0.416667,0,6,partial,0.4,0.1,80.2,"skin: 80.2 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131738,KRT33B,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.2293% (minimum 99%, Missing); bone marrow: 60.5888% (minimum 99%, Missing); colon: 78.7654% (minimum 97%, Missing); duodenum: 78.3784% (minimum 99%, Missing); esophagus: 69.3478% (minimum 97%, Missing); lung: 94.2393% (minimum 99%, Missing); lymph node: 61.8217% (minimum 97%, Missing); rectum: 76.9602% (minimum 97%, Missing); skin: 81.0673% (minimum 95%, Missing); small intestine: 79.4521% (minimum 99%, Missing); smooth muscle: 89.7328% (minimum 95%, Enhanced); spinal cord: 98.9147% (minimum 99%, Missing); spleen: 86.9210% (minimum 95%, Missing); stomach: 88.1215% (minimum 97%, Missing); thymus: 33.8821% (minimum 95%, Missing); urinary bladder: 91.6667% (minimum 97%, Missing)",-0.611179,-0.351783,-0.384112,0,6,partial,41.5,39.4,124.5,"thymus: 124.5 nTPM (manageable, limit 5); bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 2); esophagus: 28.2 nTPM (protected, limit 2); rectum: 19.1 nTPM (protected, limit 2); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 2); small intestine: 16.5 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); spleen: 9.6 nTPM (manageable, limit 5); stomach: 8.6 nTPM (protected, limit 2); smooth muscle: 7.3 nTPM (vital, limit 6); urinary bladder: 5.8 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 2 / cells in basal layer: High (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131747,TOP2A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 60.5888% (minimum 75%, Missing); esophagus: 69.3478% (minimum 70%, Missing); lymph node: 61.8217% (minimum 70%, Missing); thymus: 33.8821% (minimum 65%, Missing)",-0.311179,-0.0817829,-0.144112,0,6,partial,41.5,39.4,124.5,"thymus: 124.5 nTPM (manageable, limit 5); bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 2); esophagus: 28.2 nTPM (protected, limit 2); rectum: 19.1 nTPM (protected, limit 2); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 2); small intestine: 16.5 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); spleen: 9.6 nTPM (manageable, limit 5); stomach: 8.6 nTPM (protected, limit 2); smooth muscle: 7.3 nTPM (vital, limit 6); urinary bladder: 5.8 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 2 / cells in basal layer: High (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131747,TOP2A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 60.5888% (minimum 75%, Missing); esophagus: 69.3478% (minimum 70%, Missing); lymph node: 61.8217% (minimum 70%, Missing); thymus: 33.8821% (minimum 65%, Missing)",-0.311179,-0.0817829,-0.144112,0,6,partial,41.5,39.4,124.5,"thymus: 124.5 nTPM (manageable, limit 5); bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 3); esophagus: 28.2 nTPM (protected, limit 3); rectum: 19.1 nTPM (protected, limit 3); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 3); small intestine: 16.5 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); spleen: 9.6 nTPM (manageable, limit 5); stomach: 8.6 nTPM (protected, limit 3); smooth muscle: 7.3 nTPM (vital, limit 6); urinary bladder: 5.8 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 2 / cells in basal layer: High (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131747,TOP2A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 60.5888% (minimum 75%, Missing); esophagus: 69.3478% (minimum 70%, Missing); lymph node: 61.8217% (minimum 70%, Missing); thymus: 33.8821% (minimum 65%, Missing)",-0.311179,-0.0817829,-0.144112,0,6,partial,41.5,39.4,124.5,"thymus: 124.5 nTPM (manageable, limit 5); bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 3); esophagus: 28.2 nTPM (protected, limit 3); rectum: 19.1 nTPM (protected, limit 3); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 3); small intestine: 16.5 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); spleen: 9.6 nTPM (manageable, limit 5); stomach: 8.6 nTPM (protected, limit 3); smooth muscle: 7.3 nTPM (vital, limit 6); urinary bladder: 5.8 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 2 / cells in basal layer: High (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131747,TOP2A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 60.5888% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.3478% (minimum 70%, Baseline (adaptation disabled)); lymph node: 61.8217% (minimum 70%, Baseline (adaptation disabled)); thymus: 33.8821% (minimum 65%, Baseline (adaptation disabled))",-0.311179,-0.0817829,-0.144112,0,6,partial,41.5,39.4,124.5,"thymus: 124.5 nTPM (manageable, limit 5); bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 3); esophagus: 28.2 nTPM (protected, limit 3); rectum: 19.1 nTPM (protected, limit 3); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 3); small intestine: 16.5 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); spleen: 9.6 nTPM (manageable, limit 5); stomach: 8.6 nTPM (protected, limit 3); smooth muscle: 7.3 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 3); salivary gland: 4.2 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 2 / cells in basal layer: High (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131747,TOP2A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.4142% (minimum 95%, Missing); adrenal gland: 90.5750% (minimum 99%, Missing); amygdala: 83.7260% (minimum 99%, Missing); basal ganglia: 91.3876% (minimum 99%, Missing); bone marrow: 98.3269% (minimum 99%, Missing); cerebellum: 92.3821% (minimum 99%, Missing); cerebral cortex: 74.8286% (minimum 99%, Missing); choroid plexus: 97.0159% (minimum 99%, Missing); colon: 92.7184% (minimum 97%, Missing); duodenum: 97.4490% (minimum 99%, Missing); heart muscle: 93.8575% (minimum 99%, Missing); hippocampal formation: 84.0022% (minimum 99%, Missing); hypothalamus: 89.4090% (minimum 99%, Missing); kidney: 89.2002% (minimum 99%, Missing); liver: 92.7747% (minimum 95%, Enhanced); lung: 94.7303% (minimum 95%, Enhanced); midbrain: 89.5662% (minimum 99%, Missing); pancreas: 94.4376% (minimum 99%, Missing); parathyroid gland: 95.4403% (minimum 97%, Missing); pituitary gland: 95.8595% (minimum 99%, Missing); rectum: 94.6716% (minimum 97%, Missing); retina: 88.2727% (minimum 99%, Missing); salivary gland: 93.4557% (minimum 97%, Missing); skeletal muscle: 82.9533% (minimum 99%, Missing); small intestine: 96.4038% (minimum 99%, Missing); smooth muscle: 94.7891% (minimum 99%, Missing); spinal cord: 86.2302% (minimum 99%, Missing); stomach: 95.7994% (minimum 97%, Missing); thymus: 94.4960% (minimum 95%, Missing); tongue: 83.6344% (minimum 97%, Missing); urinary bladder: 93.7423% (minimum 97%, Missing)",-0.045858,-0.133656,-0.241714,0,11,partial,51.4,29.9,16.2,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 2); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (manageable, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 2); liver: 11.9 nTPM (vital, limit 6); salivary gland: 10.7 nTPM (protected, limit 2); urinary bladder: 10.2 nTPM (protected, limit 2); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); rectum: 8.6 nTPM (protected, limit 2); lung: 8.5 nTPM (vital, limit 6); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); stomach: 6.7 nTPM (protected, limit 2); pituitary gland: 6.6 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131773,KHDRBS3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 74.8286% (minimum 75%, Missing)",0.254142,0.136344,-0.00171401,0,11,partial,51.4,29.9,16.2,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 2); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (manageable, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 2); liver: 11.9 nTPM (vital, limit 6); salivary gland: 10.7 nTPM (protected, limit 2); urinary bladder: 10.2 nTPM (protected, limit 2); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); rectum: 8.6 nTPM (protected, limit 2); lung: 8.5 nTPM (vital, limit 6); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); stomach: 6.7 nTPM (protected, limit 2); pituitary gland: 6.6 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131773,KHDRBS3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 74.8286% (minimum 75%, Missing)",0.254142,0.136344,-0.00171401,0,11,partial,51.4,29.9,16.2,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 3); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (manageable, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 3); liver: 11.9 nTPM (vital, limit 6); salivary gland: 10.7 nTPM (protected, limit 3); urinary bladder: 10.2 nTPM (protected, limit 3); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); rectum: 8.6 nTPM (protected, limit 3); lung: 8.5 nTPM (vital, limit 6); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); stomach: 6.7 nTPM (protected, limit 3); pituitary gland: 6.6 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131773,KHDRBS3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 74.8286% (minimum 75%, Missing)",0.254142,0.136344,-0.00171401,0,11,partial,51.4,29.9,16.2,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 3); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (manageable, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 3); liver: 11.9 nTPM (vital, limit 6); salivary gland: 10.7 nTPM (protected, limit 3); urinary bladder: 10.2 nTPM (protected, limit 3); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); rectum: 8.6 nTPM (protected, limit 3); lung: 8.5 nTPM (vital, limit 6); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); stomach: 6.7 nTPM (protected, limit 3); pituitary gland: 6.6 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131773,KHDRBS3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 74.8286% (minimum 75%, Baseline (adaptation disabled))",0.254142,0.136344,-0.00171401,0,11,partial,51.4,29.9,16.2,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 3); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (manageable, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 3); liver: 11.9 nTPM (vital, limit 1); salivary gland: 10.7 nTPM (protected, limit 3); urinary bladder: 10.2 nTPM (protected, limit 3); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); rectum: 8.6 nTPM (protected, limit 3); lung: 8.5 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); stomach: 6.7 nTPM (protected, limit 3); pituitary gland: 6.6 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 3); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131773,KHDRBS3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 89.0511% (minimum 95%, Uncertain); adrenal gland: 88.7273% (minimum 99%, Missing); amygdala: 88.7273% (minimum 99%, Missing); basal ganglia: 83.8488% (minimum 99%, Missing); bone marrow: 91.7293% (minimum 99%, Uncertain); cerebellum: 94.2085% (minimum 99%, Uncertain); cerebral cortex: 88.4058% (minimum 99%, Uncertain); choroid plexus: 81.3333% (minimum 99%, Missing); colon: 89.3773% (minimum 97%, Missing); duodenum: 87.1429% (minimum 99%, Missing); esophagus: 89.3773% (minimum 97%, Uncertain); heart muscle: 85.9155% (minimum 99%, Uncertain); hippocampal formation: 88.4058% (minimum 99%, Missing); hypothalamus: 89.7059% (minimum 99%, Missing); kidney: 87.4552% (minimum 99%, Missing); liver: 90.7063% (minimum 99%, Uncertain); lung: 90.0369% (minimum 99%, Uncertain); lymph node: 91.7293% (minimum 97%, Uncertain); midbrain: 89.3773% (minimum 99%, Missing); pancreas: 90.7063% (minimum 99%, Uncertain); parathyroid gland: 88.4058% (minimum 97%, Missing); pituitary gland: 88.4058% (minimum 99%, Missing); rectum: 87.1429% (minimum 97%, Uncertain); retina: 91.7293% (minimum 99%, Missing); salivary gland: 88.7273% (minimum 97%, Missing); skeletal muscle: 86.5248% (minimum 99%, Uncertain); skin: 85.3147% (minimum 95%, Uncertain); small intestine: 89.3773% (minimum 99%, Missing); smooth muscle: 88.7273% (minimum 99%, Missing); spinal cord: 92.7757% (minimum 99%, Missing); spleen: 89.7059% (minimum 95%, Uncertain); stomach: 91.3858% (minimum 97%, Missing); thymus: 87.1429% (minimum 95%, Missing); thyroid gland: 88.4058% (minimum 95%, Uncertain); tongue: 88.0866% (minimum 97%, Missing); urinary bladder: 90.0369% (minimum 97%, Uncertain)",-0.0968531,-0.0985714,-0.176667,0,1,partial,5.6,3.6,4.2,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131848,ZSCAN5A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.203147,0.171429,0.0633333,0,1,partial,5.6,3.6,4.2,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131848,ZSCAN5A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.203147,0.171429,0.0633333,0,1,partial,5.6,3.6,4.2,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); kidney: 3.5 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); adrenal gland: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131848,ZSCAN5A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.203147,0.171429,0.0633333,0,1,partial,5.6,3.6,4.2,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); kidney: 3.5 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); adrenal gland: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131848,ZSCAN5A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.203147,0.171429,0.0633333,0,1,partial,5.6,3.6,4.2,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); kidney: 3.5 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); adrenal gland: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131848,ZSCAN5A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 75.0000% (minimum 95%, Enhanced); choroid plexus: 94.1176% (minimum 99%, Missing); heart muscle: 94.1176% (minimum 95%, Enhanced); pancreas: 78.6885% (minimum 95%, Enhanced); retina: 92.3077% (minimum 99%, Missing); skeletal muscle: 94.1176% (minimum 95%, Enhanced)",0.05,0.00959184,-0.2,0,7,partial,1.6,0.3,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131864,USP29,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.327586,0.279592,0.15,0,7,partial,1.6,0.3,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131864,USP29,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.327586,0.279592,0.15,0,7,partial,1.6,0.3,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131864,USP29,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.327586,0.279592,0.15,0,7,partial,1.6,0.3,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131864,USP29,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 75.0000% (minimum 75%, Baseline (adaptation disabled))",0.177586,0.241176,-1.11022e-16,0,7,partial,1.6,0.3,1,"bone marrow: 1.6 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131864,USP29,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"duodenum: 98.0392% (minimum 99%, Missing); lung: 98.0392% (minimum 99%, Missing); retina: 94.3396% (minimum 99%, Missing)",0.05,0.03,-0.0466038,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131914,LIN28A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.193396,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131914,LIN28A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.193396,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131914,LIN28A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.193396,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131914,LIN28A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.330392,0.280392,0.193396,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131914,LIN28A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2456% (minimum 99%, Missing); amygdala: 98.2456% (minimum 99%, Missing); basal ganglia: 96.5517% (minimum 99%, Missing); bone marrow: 98.2456% (minimum 99%, Missing); cerebral cortex: 98.2456% (minimum 99%, Missing); choroid plexus: 68.2927% (minimum 99%, Missing); hippocampal formation: 96.5517% (minimum 99%, Missing); hypothalamus: 96.5517% (minimum 99%, Missing); liver: 98.2456% (minimum 99%, Missing); midbrain: 98.2456% (minimum 99%, Missing); pituitary gland: 91.8033% (minimum 99%, Missing); retina: 98.2456% (minimum 99%, Missing); small intestine: 98.2456% (minimum 99%, Missing); spinal cord: 98.2456% (minimum 99%, Missing)",0.0324561,0.0124561,-0.307073,0,80,unavailable,2.6,0.1,0.1,"choroid plexus: 2.6 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131951,LRRC9,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.2927% (minimum 75%, Missing)",0.332456,0.282456,-0.0670732,0,80,unavailable,2.6,0.1,0.1,"choroid plexus: 2.6 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131951,LRRC9,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.2927% (minimum 75%, Missing)",0.332456,0.282456,-0.0670732,0,80,unavailable,2.6,0.1,0.1,"choroid plexus: 2.6 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131951,LRRC9,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.2927% (minimum 75%, Missing)",0.332456,0.282456,-0.0670732,0,80,unavailable,2.6,0.1,0.1,"choroid plexus: 2.6 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131951,LRRC9,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.2927% (minimum 75%, Baseline (adaptation disabled))",0.332456,0.282456,-0.0670732,0,80,unavailable,2.6,0.1,0.1,"choroid plexus: 2.6 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000131951,LRRC9,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 84.6154% (minimum 99%, Missing); basal ganglia: 88.2716% (minimum 99%, Missing); bone marrow: 91.0828% (minimum 95%, Enhanced); cerebellum: 74.4792% (minimum 95%, Enhanced); cerebral cortex: 82.6590% (minimum 99%, Missing); choroid plexus: 82.1839% (minimum 99%, Missing); colon: 83.1395% (minimum 97%, Missing); duodenum: 92.2581% (minimum 99%, Missing); esophagus: 72.9592% (minimum 97%, Missing); hippocampal formation: 84.6154% (minimum 99%, Missing); hypothalamus: 86.1446% (minimum 99%, Missing); kidney: 92.8571% (minimum 99%, Missing); liver: 90.5063% (minimum 95%, Enhanced); lung: 94.7020% (minimum 95%, Enhanced); midbrain: 85.1190% (minimum 99%, Missing); pancreas: 73.7113% (minimum 99%, Missing); pituitary gland: 92.8571% (minimum 99%, Missing); rectum: 95.9732% (minimum 97%, Missing); retina: 94.0789% (minimum 99%, Missing); salivary gland: 88.2716% (minimum 97%, Missing); skin: 74.0933% (minimum 95%, Missing); small intestine: 78.1421% (minimum 99%, Missing); spinal cord: 82.6590% (minimum 99%, Missing); stomach: 91.0828% (minimum 97%, Missing)",-0.209067,-0.240408,-0.252887,0,5,partial,5.1,5.3,5,"esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132016,BRME1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 73.7113% (minimum 75%, Missing)",0.0909326,0.0295918,-0.0128866,0,5,partial,5.1,5.3,5,"esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132016,BRME1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 73.7113% (minimum 75%, Missing)",0.0909326,0.0295918,-0.0128866,0,5,partial,5.1,5.3,5,"esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132016,BRME1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 73.7113% (minimum 75%, Missing)",0.0909326,0.0295918,-0.0128866,0,5,partial,5.1,5.3,5,"esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132016,BRME1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 74.4792% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.7113% (minimum 75%, Baseline (adaptation disabled))",0.0909326,0.0295918,-0.0128866,0,5,partial,5.1,5.3,5,"esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132016,BRME1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.3382% (minimum 95%, Missing); adrenal gland: 86.1702% (minimum 99%, Missing); amygdala: 90.0000% (minimum 99%, Missing); basal ganglia: 90.5028% (minimum 99%, Missing); bone marrow: 98.1818% (minimum 99%, Missing); cerebellum: 97.2000% (minimum 99%, Missing); cerebral cortex: 92.7481% (minimum 99%, Missing); choroid plexus: 88.8483% (minimum 99%, Missing); colon: 90.6716% (minimum 97%, Missing); duodenum: 94.9219% (minimum 99%, Missing); esophagus: 93.6416% (minimum 97%, Missing); heart muscle: 92.0455% (minimum 99%, Missing); hippocampal formation: 89.5028% (minimum 99%, Missing); hypothalamus: 90.5028% (minimum 99%, Missing); kidney: 89.3382% (minimum 99%, Missing); liver: 96.8127% (minimum 99%, Missing); lung: 89.5028% (minimum 99%, Missing); lymph node: 95.8580% (minimum 97%, Missing); midbrain: 87.7256% (minimum 99%, Missing); pancreas: 91.5254% (minimum 99%, Missing); parathyroid gland: 82.5127% (minimum 97%, Missing); pituitary gland: 85.4130% (minimum 99%, Missing); rectum: 92.7481% (minimum 97%, Missing); retina: 79.1531% (minimum 99%, Missing); salivary gland: 88.8483% (minimum 97%, Missing); skeletal muscle: 96.6203% (minimum 99%, Missing); skin: 91.8715% (minimum 95%, Missing); small intestine: 93.8224% (minimum 99%, Missing); smooth muscle: 91.8715% (minimum 99%, Missing); spinal cord: 88.2033% (minimum 99%, Missing); spleen: 93.1034% (minimum 95%, Missing); stomach: 88.2033% (minimum 97%, Missing); thymus: 94.1860% (minimum 95%, Missing); thyroid gland: 84.0830% (minimum 95%, Missing); tongue: 93.2821% (minimum 97%, Missing); urinary bladder: 89.3382% (minimum 97%, Missing)",-0.10917,-0.144873,-0.198469,0,80,unavailable,12.8,10.3,9.2,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 2); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); lung: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 2); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132122,SPATA6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19083,0.125127,0.0415309,0,80,unavailable,12.8,10.3,9.2,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 2); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); lung: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 2); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132122,SPATA6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19083,0.125127,0.0415309,0,80,unavailable,12.8,10.3,9.2,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 3); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 3); lung: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132122,SPATA6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19083,0.125127,0.0415309,0,80,unavailable,12.8,10.3,9.2,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 3); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 3); lung: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132122,SPATA6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19083,0.125127,0.0415309,0,80,unavailable,12.8,10.3,9.2,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 3); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 3); lung: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132122,SPATA6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.4543% (minimum 99%, Missing); amygdala: 98.3146% (minimum 99%, Missing); basal ganglia: 98.2358% (minimum 99%, Missing); bone marrow: 96.9913% (minimum 99%, Missing); cerebral cortex: 98.4727% (minimum 99%, Missing); choroid plexus: 98.4727% (minimum 99%, Missing); duodenum: 98.8701% (minimum 99%, Missing); heart muscle: 98.6312% (minimum 99%, Uncertain); hippocampal formation: 98.3936% (minimum 99%, Missing); hypothalamus: 98.3936% (minimum 99%, Missing); kidney: 96.9146% (minimum 99%, Missing); liver: 96.2294% (minimum 99%, Missing); midbrain: 97.7654% (minimum 99%, Missing); pancreas: 97.9217% (minimum 99%, Missing); pituitary gland: 97.8435% (minimum 99%, Missing); retina: 98.2358% (minimum 99%, Missing); skeletal muscle: 96.1538% (minimum 99%, Uncertain); small intestine: 98.8701% (minimum 99%, Missing); smooth muscle: 98.7107% (minimum 99%, Uncertain); spinal cord: 97.4543% (minimum 99%, Missing)",0.0276536,0.00145123,-0.0284615,0,6,partial,4.9,3.6,2.8,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132141,CCT6B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327654,0.271451,0.211538,0,6,partial,4.9,3.6,2.8,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132141,CCT6B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327654,0.271451,0.211538,0,6,partial,4.9,3.6,2.8,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 3); adrenal gland: 3.2 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132141,CCT6B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327654,0.271451,0.211538,0,6,partial,4.9,3.6,2.8,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 3); adrenal gland: 3.2 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132141,CCT6B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327654,0.271451,0.211538,0,6,partial,4.9,3.6,2.8,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 3); adrenal gland: 3.2 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132141,CCT6B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3448% (minimum 90%, Approved); adrenal gland: 71.8310% (minimum 99%, Missing); amygdala: 75.5556% (minimum 99%, Missing); basal ganglia: 69.3878% (minimum 99%, Missing); bone marrow: 54.5455% (minimum 99%, Missing); cerebellum: 61.0778% (minimum 99%, Missing); cerebral cortex: 62.5767% (minimum 99%, Missing); choroid plexus: 88.6957% (minimum 99%, Missing); colon: 63.3540% (minimum 97%, Missing); duodenum: 60.7143% (minimum 99%, Missing); esophagus: 54.2553% (minimum 97%, Missing); heart muscle: 73.9130% (minimum 99%, Missing); hippocampal formation: 73.3813% (minimum 99%, Missing); hypothalamus: 73.9130% (minimum 99%, Missing); kidney: 75.5556% (minimum 99%, Missing); liver: 69.3878% (minimum 99%, Missing); lung: 76.1194% (minimum 99%, Missing); lymph node: 50.7463% (minimum 97%, Missing); midbrain: 74.4526% (minimum 99%, Missing); pancreas: 79.0698% (minimum 99%, Missing); parathyroid gland: 73.9130% (minimum 97%, Missing); pituitary gland: 80.3150% (minimum 99%, Missing); rectum: 62.5767% (minimum 97%, Missing); retina: 52.5773% (minimum 99%, Missing); salivary gland: 73.9130% (minimum 97%, Missing); skeletal muscle: 62.5767% (minimum 99%, Missing); skin: 55.1351% (minimum 95%, Missing); small intestine: 62.9630% (minimum 99%, Missing); smooth muscle: 52.0408% (minimum 98%, Approved); spinal cord: 72.8571% (minimum 99%, Missing); spleen: 57.9545% (minimum 95%, Missing); stomach: 71.3287% (minimum 97%, Missing); thymus: 51.2563% (minimum 95%, Missing); thyroid gland: 74.4526% (minimum 95%, Missing); tongue: 56.9832% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.437437,-0.462537,-0.464227,0,1,partial,9.4,9.9,9.7,"lymph node: 9.9 nTPM (protected, limit 2); thymus: 9.7 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); tongue: 7.7 nTPM (protected, limit 2); spleen: 7.4 nTPM (manageable, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 2); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 2); liver: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132436,FIGNL1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.8310% (minimum 75%, Missing); basal ganglia: 69.3878% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 61.0778% (minimum 75%, Missing); cerebral cortex: 62.5767% (minimum 75%, Missing); colon: 63.3540% (minimum 70%, Missing); duodenum: 60.7143% (minimum 75%, Missing); esophagus: 54.2553% (minimum 70%, Missing); heart muscle: 73.9130% (minimum 75%, Missing); hippocampal formation: 73.3813% (minimum 75%, Missing); hypothalamus: 73.9130% (minimum 75%, Missing); liver: 69.3878% (minimum 75%, Missing); lymph node: 50.7463% (minimum 70%, Missing); midbrain: 74.4526% (minimum 75%, Missing); rectum: 62.5767% (minimum 70%, Missing); retina: 52.5773% (minimum 75%, Missing); skeletal muscle: 62.5767% (minimum 75%, Missing); skin: 55.1351% (minimum 65%, Missing); small intestine: 62.9630% (minimum 75%, Missing); smooth muscle: 52.0408% (minimum 70%, Approved); spinal cord: 72.8571% (minimum 75%, Missing); spleen: 57.9545% (minimum 65%, Missing); thymus: 51.2563% (minimum 65%, Missing); tongue: 56.9832% (minimum 70%, Missing)",-0.137437,-0.192537,-0.224227,0,1,partial,9.4,9.9,9.7,"lymph node: 9.9 nTPM (protected, limit 2); thymus: 9.7 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); tongue: 7.7 nTPM (protected, limit 2); spleen: 7.4 nTPM (manageable, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 2); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 2); liver: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132436,FIGNL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.8310% (minimum 75%, Missing); basal ganglia: 69.3878% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 61.0778% (minimum 75%, Missing); cerebral cortex: 62.5767% (minimum 75%, Missing); colon: 63.3540% (minimum 70%, Missing); duodenum: 60.7143% (minimum 75%, Missing); esophagus: 54.2553% (minimum 70%, Missing); heart muscle: 73.9130% (minimum 75%, Missing); hippocampal formation: 73.3813% (minimum 75%, Missing); hypothalamus: 73.9130% (minimum 75%, Missing); liver: 69.3878% (minimum 75%, Missing); lymph node: 50.7463% (minimum 70%, Missing); midbrain: 74.4526% (minimum 75%, Missing); rectum: 62.5767% (minimum 70%, Missing); retina: 52.5773% (minimum 75%, Missing); skeletal muscle: 62.5767% (minimum 75%, Missing); skin: 55.1351% (minimum 65%, Missing); small intestine: 62.9630% (minimum 75%, Missing); smooth muscle: 52.0408% (minimum 70%, Approved); spinal cord: 72.8571% (minimum 75%, Missing); spleen: 57.9545% (minimum 65%, Missing); thymus: 51.2563% (minimum 65%, Missing); tongue: 56.9832% (minimum 70%, Missing)",-0.137437,-0.192537,-0.224227,0,1,partial,9.4,9.9,9.7,"lymph node: 9.9 nTPM (protected, limit 3); thymus: 9.7 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); tongue: 7.7 nTPM (protected, limit 3); spleen: 7.4 nTPM (manageable, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 3); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 3); liver: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); hypothalamus: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132436,FIGNL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.8310% (minimum 75%, Missing); basal ganglia: 69.3878% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 61.0778% (minimum 75%, Missing); cerebral cortex: 62.5767% (minimum 75%, Missing); colon: 63.3540% (minimum 70%, Missing); duodenum: 60.7143% (minimum 75%, Missing); esophagus: 54.2553% (minimum 70%, Missing); heart muscle: 73.9130% (minimum 75%, Missing); hippocampal formation: 73.3813% (minimum 75%, Missing); hypothalamus: 73.9130% (minimum 75%, Missing); liver: 69.3878% (minimum 75%, Missing); lymph node: 50.7463% (minimum 70%, Missing); midbrain: 74.4526% (minimum 75%, Missing); rectum: 62.5767% (minimum 70%, Missing); retina: 52.5773% (minimum 75%, Missing); skeletal muscle: 62.5767% (minimum 75%, Missing); skin: 55.1351% (minimum 65%, Missing); small intestine: 62.9630% (minimum 75%, Missing); smooth muscle: 52.0408% (minimum 70%, Approved); spinal cord: 72.8571% (minimum 75%, Missing); spleen: 57.9545% (minimum 65%, Missing); thymus: 51.2563% (minimum 65%, Missing); tongue: 56.9832% (minimum 70%, Missing)",-0.137437,-0.192537,-0.224227,0,1,partial,9.4,9.9,9.7,"lymph node: 9.9 nTPM (protected, limit 3); thymus: 9.7 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); tongue: 7.7 nTPM (protected, limit 3); spleen: 7.4 nTPM (manageable, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 3); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 3); liver: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); hypothalamus: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132436,FIGNL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.8310% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 69.3878% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 54.5455% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.0778% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.5767% (minimum 75%, Baseline (adaptation disabled)); colon: 63.3540% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.7143% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.2553% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 73.9130% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.3813% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.9130% (minimum 75%, Baseline (adaptation disabled)); liver: 69.3878% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.7463% (minimum 70%, Baseline (adaptation disabled)); midbrain: 74.4526% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.5767% (minimum 70%, Baseline (adaptation disabled)); retina: 52.5773% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 62.5767% (minimum 75%, Baseline (adaptation disabled)); skin: 55.1351% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.9630% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 52.0408% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.8571% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.9545% (minimum 65%, Baseline (adaptation disabled)); thymus: 51.2563% (minimum 65%, Baseline (adaptation disabled)); tongue: 56.9832% (minimum 70%, Baseline (adaptation disabled))",-0.137437,-0.192537,-0.229592,0,1,partial,9.4,9.9,9.7,"lymph node: 9.9 nTPM (protected, limit 3); thymus: 9.7 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); tongue: 7.7 nTPM (protected, limit 3); spleen: 7.4 nTPM (manageable, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 3); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 3); liver: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); hypothalamus: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132436,FIGNL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.024359,0.03,0.01,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132446,FTHL17,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.324359,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132446,FTHL17,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.324359,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132446,FTHL17,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.324359,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132446,FTHL17,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.324359,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132446,FTHL17,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 98.6486% (minimum 99%, Missing); heart muscle: 53.6765% (minimum 99%, Missing); kidney: 45.9119% (minimum 99%, Missing); liver: 93.5897% (minimum 99%, Missing); lung: 96.0526% (minimum 99%, Missing); pancreas: 67.5926% (minimum 99%, Missing); parathyroid gland: 92.4051% (minimum 97%, Missing); pituitary gland: 97.3333% (minimum 99%, Missing); retina: 98.6486% (minimum 99%, Missing); skeletal muscle: 60.8333% (minimum 99%, Missing); small intestine: 97.3333% (minimum 99%, Missing); smooth muscle: 98.6486% (minimum 99%, Missing); stomach: 81.1111% (minimum 97%, Missing); tongue: 80.2198% (minimum 97%, Missing)",0.0364865,-0.167802,-0.530881,0,80,unavailable,8.6,1.8,0.1,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132464,ENAM,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 53.6765% (minimum 75%, Missing); kidney: 45.9119% (minimum 75%, Missing); pancreas: 67.5926% (minimum 75%, Missing); skeletal muscle: 60.8333% (minimum 75%, Missing)",0.336486,0.102198,-0.290881,0,80,unavailable,8.6,1.8,0.1,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132464,ENAM,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 53.6765% (minimum 75%, Missing); kidney: 45.9119% (minimum 75%, Missing); pancreas: 67.5926% (minimum 75%, Missing); skeletal muscle: 60.8333% (minimum 75%, Missing)",0.336486,0.102198,-0.290881,0,80,unavailable,8.6,1.8,0.1,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132464,ENAM,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 53.6765% (minimum 75%, Missing); kidney: 45.9119% (minimum 75%, Missing); pancreas: 67.5926% (minimum 75%, Missing); skeletal muscle: 60.8333% (minimum 75%, Missing)",0.336486,0.102198,-0.290881,0,80,unavailable,8.6,1.8,0.1,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132464,ENAM,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 53.6765% (minimum 75%, Baseline (adaptation disabled)); kidney: 45.9119% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.5926% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 60.8333% (minimum 75%, Baseline (adaptation disabled))",0.336486,0.102198,-0.290881,0,80,unavailable,8.6,1.8,0.1,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132464,ENAM,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5124% (minimum 99%, Missing); basal ganglia: 98.6755% (minimum 99%, Missing); choroid plexus: 90.3030% (minimum 99%, Missing); hippocampal formation: 98.6755% (minimum 99%, Missing); hypothalamus: 98.1878% (minimum 99%, Missing); lung: 97.3856% (minimum 99%, Missing); pituitary gland: 98.1878% (minimum 99%, Missing); retina: 98.5124% (minimum 99%, Missing); smooth muscle: 97.5450% (minimum 99%, Missing)",0.00819936,0.0249917,-0.0869697,0,80,unavailable,6.4,0.3,2.6,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132554,RGS22,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308199,0.294992,0.15303,0,80,unavailable,6.4,0.3,2.6,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132554,RGS22,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308199,0.294992,0.15303,0,80,unavailable,6.4,0.3,2.6,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132554,RGS22,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308199,0.294992,0.15303,0,80,unavailable,6.4,0.3,2.6,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132554,RGS22,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308199,0.294992,0.15303,0,80,unavailable,6.4,0.3,2.6,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132554,RGS22,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132631,SCP2D1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132631,SCP2D1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132631,SCP2D1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132631,SCP2D1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132631,SCP2D1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 98.1366% (minimum 99%, Missing); lymph node: 83.1579% (minimum 97%, Missing); retina: 86.8132% (minimum 99%, Missing); skeletal muscle: 84.4920% (minimum 99%, Missing); small intestine: 98.7500% (minimum 99%, Missing); spleen: 94.0476% (minimum 95%, Missing); urinary bladder: 76.3285% (minimum 97%, Missing)",-0.00952381,-0.206715,-0.14508,0,80,unavailable,2.9,4.9,1,"urinary bladder: 4.9 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132681,ATP1A4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.290476,0.063285,0.0949198,0,80,unavailable,2.9,4.9,1,"urinary bladder: 4.9 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132681,ATP1A4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.290476,0.063285,0.0949198,0,80,unavailable,2.9,4.9,1,"urinary bladder: 4.9 nTPM (protected, limit 3); lymph node: 3.2 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132681,ATP1A4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.290476,0.063285,0.0949198,0,80,unavailable,2.9,4.9,1,"urinary bladder: 4.9 nTPM (protected, limit 3); lymph node: 3.2 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132681,ATP1A4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.290476,0.063285,0.0949198,0,80,unavailable,2.9,4.9,1,"urinary bladder: 4.9 nTPM (protected, limit 3); lymph node: 3.2 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132681,ATP1A4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.2659% (minimum 99%, Missing); bone marrow: 87.3288% (minimum 99%, Missing); choroid plexus: 98.6460% (minimum 99%, Missing); colon: 95.5056% (minimum 97%, Missing); duodenum: 97.5143% (minimum 99%, Missing); hypothalamus: 98.2659% (minimum 99%, Missing); kidney: 94.4444% (minimum 99%, Missing); pancreas: 97.8887% (minimum 99%, Missing); parathyroid gland: 96.2264% (minimum 97%, Missing); pituitary gland: 95.6848% (minimum 99%, Missing); rectum: 94.6197% (minimum 97%, Missing); retina: 97.3282% (minimum 99%, Missing); salivary gland: 96.5909% (minimum 97%, Missing); small intestine: 97.5143% (minimum 99%, Missing)",0.0122642,-0.0238033,-0.116712,0,80,unavailable,7.4,2.9,2,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132749,TESMIN,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312264,0.246197,0.123288,0,80,unavailable,7.4,2.9,2,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132749,TESMIN,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312264,0.246197,0.123288,0,80,unavailable,7.4,2.9,2,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132749,TESMIN,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312264,0.246197,0.123288,0,80,unavailable,7.4,2.9,2,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132749,TESMIN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312264,0.246197,0.123288,0,80,unavailable,7.4,2.9,2,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132749,TESMIN,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.5238% (minimum 99%, Missing); amygdala: 34.7222% (minimum 99%, Missing); basal ganglia: 33.7838% (minimum 99%, Missing); cerebellum: 11.2613% (minimum 99%, Missing); cerebral cortex: 14.6199% (minimum 99%, Missing); choroid plexus: 86.2069% (minimum 99%, Missing); duodenum: 96.1538% (minimum 99%, Missing); hippocampal formation: 33.3333% (minimum 99%, Missing); hypothalamus: 19.6850% (minimum 99%, Missing); kidney: 89.2857% (minimum 95%, Enhanced); lung: 83.3333% (minimum 95%, Enhanced); lymph node: 96.1538% (minimum 97%, Missing); midbrain: 31.6456% (minimum 99%, Missing); pancreas: 92.5926% (minimum 99%, Missing); pituitary gland: 14.4509% (minimum 99%, Missing); retina: 14.8810% (minimum 99%, Missing); skeletal muscle: 92.5926% (minimum 95%, Enhanced); small intestine: 89.2857% (minimum 99%, Missing); spinal cord: 56.8182% (minimum 99%, Missing); stomach: 80.6452% (minimum 97%, Missing)",0.0115385,-0.163548,-0.877387,0,3,partial,19.7,0.6,0.1,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132932,ATP8A2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.5238% (minimum 75%, Missing); amygdala: 34.7222% (minimum 75%, Missing); basal ganglia: 33.7838% (minimum 75%, Missing); cerebellum: 11.2613% (minimum 75%, Missing); cerebral cortex: 14.6199% (minimum 75%, Missing); hippocampal formation: 33.3333% (minimum 75%, Missing); hypothalamus: 19.6850% (minimum 75%, Missing); midbrain: 31.6456% (minimum 75%, Missing); pituitary gland: 14.4509% (minimum 75%, Missing); retina: 14.8810% (minimum 75%, Missing); spinal cord: 56.8182% (minimum 75%, Missing)",0.311538,0.106452,-0.637387,0,3,partial,19.7,0.6,0.1,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132932,ATP8A2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.5238% (minimum 75%, Missing); amygdala: 34.7222% (minimum 75%, Missing); basal ganglia: 33.7838% (minimum 75%, Missing); cerebellum: 11.2613% (minimum 75%, Missing); cerebral cortex: 14.6199% (minimum 75%, Missing); hippocampal formation: 33.3333% (minimum 75%, Missing); hypothalamus: 19.6850% (minimum 75%, Missing); midbrain: 31.6456% (minimum 75%, Missing); pituitary gland: 14.4509% (minimum 75%, Missing); retina: 14.8810% (minimum 75%, Missing); spinal cord: 56.8182% (minimum 75%, Missing)",0.311538,0.106452,-0.637387,0,3,partial,19.7,0.6,0.1,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132932,ATP8A2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.5238% (minimum 75%, Missing); amygdala: 34.7222% (minimum 75%, Missing); basal ganglia: 33.7838% (minimum 75%, Missing); cerebellum: 11.2613% (minimum 75%, Missing); cerebral cortex: 14.6199% (minimum 75%, Missing); hippocampal formation: 33.3333% (minimum 75%, Missing); hypothalamus: 19.6850% (minimum 75%, Missing); midbrain: 31.6456% (minimum 75%, Missing); pituitary gland: 14.4509% (minimum 75%, Missing); retina: 14.8810% (minimum 75%, Missing); spinal cord: 56.8182% (minimum 75%, Missing)",0.311538,0.106452,-0.637387,0,3,partial,19.7,0.6,0.1,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132932,ATP8A2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.5238% (minimum 75%, Baseline (adaptation disabled)); amygdala: 34.7222% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 33.7838% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 11.2613% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 14.6199% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 33.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 19.6850% (minimum 75%, Baseline (adaptation disabled)); midbrain: 31.6456% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 14.4509% (minimum 75%, Baseline (adaptation disabled)); retina: 14.8810% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.8182% (minimum 75%, Baseline (adaptation disabled))",0.311538,0.106452,-0.637387,0,3,partial,19.7,0.6,0.1,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132932,ATP8A2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.2109% (minimum 95%, Uncertain); adrenal gland: 74.9175% (minimum 99%, Missing); amygdala: 89.3701% (minimum 99%, Missing); basal ganglia: 88.6719% (minimum 99%, Missing); bone marrow: 65.2299% (minimum 99%, Missing); cerebellum: 88.6719% (minimum 99%, Missing); cerebral cortex: 81.6547% (minimum 99%, Missing); choroid plexus: 87.3077% (minimum 99%, Missing); colon: 79.9296% (minimum 97%, Missing); duodenum: 79.0941% (minimum 99%, Missing); esophagus: 75.4153% (minimum 97%, Missing); heart muscle: 81.3620% (minimum 99%, Missing); hippocampal formation: 88.3268% (minimum 99%, Missing); hypothalamus: 88.6719% (minimum 99%, Missing); kidney: 78.2759% (minimum 99%, Missing); liver: 77.2109% (minimum 99%, Missing); lung: 77.7397% (minimum 99%, Missing); lymph node: 69.4190% (minimum 97%, Missing); midbrain: 86.6412% (minimum 99%, Missing); pancreas: 81.0714% (minimum 99%, Missing); parathyroid gland: 81.0714% (minimum 97%, Missing); pituitary gland: 82.8467% (minimum 99%, Missing); rectum: 79.0941% (minimum 97%, Missing); retina: 72.0635% (minimum 99%, Missing); salivary gland: 80.2120% (minimum 97%, Missing); skeletal muscle: 79.0941% (minimum 99%, Missing); skin: 74.9175% (minimum 95%, Missing); small intestine: 78.0069% (minimum 99%, Missing); smooth muscle: 77.4744% (minimum 99%, Missing); spinal cord: 83.1502% (minimum 99%, Missing); spleen: 75.6667% (minimum 95%, Missing); stomach: 76.1745% (minimum 97%, Missing); thymus: 69.8462% (minimum 95%, Missing); thyroid gland: 73.2258% (minimum 95%, Missing); tongue: 75.4153% (minimum 97%, Missing); urinary bladder: 76.6892% (minimum 97%, Missing)",-0.251538,-0.27581,-0.337701,0,3,partial,12.1,10,9.8,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); spleen: 7.3 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 2); urinary bladder: 6.9 nTPM (protected, limit 2); liver: 6.7 nTPM (vital, limit 1); adipose tissue: 6.7 nTPM (manageable, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); duodenum: 6 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); parathyroid gland: 5.3 nTPM (protected, limit 2); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132950,ZMYM5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.9175% (minimum 75%, Missing); bone marrow: 65.2299% (minimum 75%, Missing); lymph node: 69.4190% (minimum 70%, Missing); retina: 72.0635% (minimum 75%, Missing)",0.0484615,-0.0058104,-0.0977011,0,3,partial,12.1,10,9.8,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); spleen: 7.3 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 2); urinary bladder: 6.9 nTPM (protected, limit 2); liver: 6.7 nTPM (vital, limit 1); adipose tissue: 6.7 nTPM (manageable, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); duodenum: 6 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); parathyroid gland: 5.3 nTPM (protected, limit 2); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132950,ZMYM5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.9175% (minimum 75%, Missing); bone marrow: 65.2299% (minimum 75%, Missing); lymph node: 69.4190% (minimum 70%, Missing); retina: 72.0635% (minimum 75%, Missing)",0.0484615,-0.0058104,-0.0977011,0,3,partial,12.1,10,9.8,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); spleen: 7.3 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 3); urinary bladder: 6.9 nTPM (protected, limit 3); liver: 6.7 nTPM (vital, limit 1); adipose tissue: 6.7 nTPM (manageable, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); duodenum: 6 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); parathyroid gland: 5.3 nTPM (protected, limit 3); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132950,ZMYM5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.9175% (minimum 75%, Missing); bone marrow: 65.2299% (minimum 75%, Missing); lymph node: 69.4190% (minimum 70%, Missing); retina: 72.0635% (minimum 75%, Missing)",0.0484615,-0.0058104,-0.0977011,0,3,partial,12.1,10,9.8,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); spleen: 7.3 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 3); urinary bladder: 6.9 nTPM (protected, limit 3); liver: 6.7 nTPM (vital, limit 1); adipose tissue: 6.7 nTPM (manageable, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); duodenum: 6 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); parathyroid gland: 5.3 nTPM (protected, limit 3); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132950,ZMYM5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.9175% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 65.2299% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.4190% (minimum 70%, Baseline (adaptation disabled)); retina: 72.0635% (minimum 75%, Baseline (adaptation disabled))",0.0484615,-0.0058104,-0.0977011,0,3,partial,12.1,10,9.8,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); spleen: 7.3 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 3); urinary bladder: 6.9 nTPM (protected, limit 3); liver: 6.7 nTPM (vital, limit 1); adipose tissue: 6.7 nTPM (manageable, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); duodenum: 6 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); parathyroid gland: 5.3 nTPM (protected, limit 3); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132950,ZMYM5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.8235% (minimum 95%, Missing); adrenal gland: 63.1579% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 77.9221% (minimum 99%, Missing); bone marrow: 37.2671% (minimum 99%, Missing); cerebellum: 56.0748% (minimum 99%, Missing); cerebral cortex: 60.0000% (minimum 99%, Missing); choroid plexus: 68.1818% (minimum 99%, Missing); colon: 57.1429% (minimum 97%, Missing); duodenum: 62.5000% (minimum 99%, Missing); esophagus: 56.0748% (minimum 97%, Missing); heart muscle: 36.5854% (minimum 99%, Missing); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 80.0000% (minimum 99%, Missing); kidney: 55.0459% (minimum 99%, Missing); liver: 60.0000% (minimum 99%, Missing); lung: 50.4202% (minimum 99%, Missing); lymph node: 45.4545% (minimum 97%, Missing); midbrain: 76.9231% (minimum 99%, Missing); pancreas: 59.4059% (minimum 99%, Missing); parathyroid gland: 48.7805% (minimum 97%, Missing); pituitary gland: 67.4157% (minimum 99%, Missing); rectum: 52.1739% (minimum 97%, Missing); retina: 31.2500% (minimum 99%, Missing); salivary gland: 62.5000% (minimum 97%, Missing); skeletal muscle: 12.2951% (minimum 99%, Missing); skin: 52.1739% (minimum 95%, Missing); small intestine: 61.8557% (minimum 99%, Missing); smooth muscle: 52.6316% (minimum 99%, Missing); spinal cord: 68.9655% (minimum 99%, Missing); spleen: 51.2821% (minimum 95%, Missing); stomach: 56.6038% (minimum 97%, Missing); thymus: 46.5116% (minimum 95%, Missing); thyroid gland: 48.7805% (minimum 95%, Missing); tongue: 27.0270% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",-0.484884,-0.69973,-0.867049,0,80,unavailable,42.8,16.2,6.9,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 2); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thymus: 6.9 nTPM (manageable, limit 5); thyroid gland: 6.3 nTPM (manageable, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); cerebellum: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); urinary bladder: 4.5 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132953,XPO4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.8235% (minimum 65%, Missing); adrenal gland: 63.1579% (minimum 75%, Missing); bone marrow: 37.2671% (minimum 75%, Missing); cerebellum: 56.0748% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 62.5000% (minimum 75%, Missing); esophagus: 56.0748% (minimum 70%, Missing); heart muscle: 36.5854% (minimum 75%, Missing); kidney: 55.0459% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 50.4202% (minimum 75%, Missing); lymph node: 45.4545% (minimum 70%, Missing); pancreas: 59.4059% (minimum 75%, Missing); parathyroid gland: 48.7805% (minimum 70%, Missing); pituitary gland: 67.4157% (minimum 75%, Missing); rectum: 52.1739% (minimum 70%, Missing); retina: 31.2500% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 12.2951% (minimum 75%, Missing); skin: 52.1739% (minimum 65%, Missing); small intestine: 61.8557% (minimum 75%, Missing); smooth muscle: 52.6316% (minimum 75%, Missing); spinal cord: 68.9655% (minimum 75%, Missing); spleen: 51.2821% (minimum 65%, Missing); stomach: 56.6038% (minimum 70%, Missing); thymus: 46.5116% (minimum 65%, Missing); thyroid gland: 48.7805% (minimum 65%, Missing); tongue: 27.0270% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.184884,-0.42973,-0.627049,0,80,unavailable,42.8,16.2,6.9,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 2); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thymus: 6.9 nTPM (manageable, limit 5); thyroid gland: 6.3 nTPM (manageable, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); cerebellum: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); urinary bladder: 4.5 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132953,XPO4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.8235% (minimum 65%, Missing); adrenal gland: 63.1579% (minimum 75%, Missing); bone marrow: 37.2671% (minimum 75%, Missing); cerebellum: 56.0748% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 62.5000% (minimum 75%, Missing); esophagus: 56.0748% (minimum 70%, Missing); heart muscle: 36.5854% (minimum 75%, Missing); kidney: 55.0459% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 50.4202% (minimum 75%, Missing); lymph node: 45.4545% (minimum 70%, Missing); pancreas: 59.4059% (minimum 75%, Missing); parathyroid gland: 48.7805% (minimum 70%, Missing); pituitary gland: 67.4157% (minimum 75%, Missing); rectum: 52.1739% (minimum 70%, Missing); retina: 31.2500% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 12.2951% (minimum 75%, Missing); skin: 52.1739% (minimum 65%, Missing); small intestine: 61.8557% (minimum 75%, Missing); smooth muscle: 52.6316% (minimum 75%, Missing); spinal cord: 68.9655% (minimum 75%, Missing); spleen: 51.2821% (minimum 65%, Missing); stomach: 56.6038% (minimum 70%, Missing); thymus: 46.5116% (minimum 65%, Missing); thyroid gland: 48.7805% (minimum 65%, Missing); tongue: 27.0270% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.184884,-0.42973,-0.627049,0,80,unavailable,42.8,16.2,6.9,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 3); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thymus: 6.9 nTPM (manageable, limit 5); thyroid gland: 6.3 nTPM (manageable, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); cerebellum: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3); urinary bladder: 4.5 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132953,XPO4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.8235% (minimum 65%, Missing); adrenal gland: 63.1579% (minimum 75%, Missing); bone marrow: 37.2671% (minimum 75%, Missing); cerebellum: 56.0748% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 62.5000% (minimum 75%, Missing); esophagus: 56.0748% (minimum 70%, Missing); heart muscle: 36.5854% (minimum 75%, Missing); kidney: 55.0459% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 50.4202% (minimum 75%, Missing); lymph node: 45.4545% (minimum 70%, Missing); pancreas: 59.4059% (minimum 75%, Missing); parathyroid gland: 48.7805% (minimum 70%, Missing); pituitary gland: 67.4157% (minimum 75%, Missing); rectum: 52.1739% (minimum 70%, Missing); retina: 31.2500% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 12.2951% (minimum 75%, Missing); skin: 52.1739% (minimum 65%, Missing); small intestine: 61.8557% (minimum 75%, Missing); smooth muscle: 52.6316% (minimum 75%, Missing); spinal cord: 68.9655% (minimum 75%, Missing); spleen: 51.2821% (minimum 65%, Missing); stomach: 56.6038% (minimum 70%, Missing); thymus: 46.5116% (minimum 65%, Missing); thyroid gland: 48.7805% (minimum 65%, Missing); tongue: 27.0270% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.184884,-0.42973,-0.627049,0,80,unavailable,42.8,16.2,6.9,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 3); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thymus: 6.9 nTPM (manageable, limit 5); thyroid gland: 6.3 nTPM (manageable, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); cerebellum: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3); urinary bladder: 4.5 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132953,XPO4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.8235% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.1579% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 37.2671% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.0748% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.1818% (minimum 75%, Baseline (adaptation disabled)); colon: 57.1429% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.5000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 56.0748% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 36.5854% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.0459% (minimum 75%, Baseline (adaptation disabled)); liver: 60.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 50.4202% (minimum 75%, Baseline (adaptation disabled)); lymph node: 45.4545% (minimum 70%, Baseline (adaptation disabled)); pancreas: 59.4059% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 48.7805% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.4157% (minimum 75%, Baseline (adaptation disabled)); rectum: 52.1739% (minimum 70%, Baseline (adaptation disabled)); retina: 31.2500% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 12.2951% (minimum 75%, Baseline (adaptation disabled)); skin: 52.1739% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.8557% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 52.6316% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.9655% (minimum 75%, Baseline (adaptation disabled)); spleen: 51.2821% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.6038% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.5116% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 48.7805% (minimum 65%, Baseline (adaptation disabled)); tongue: 27.0270% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 70%, Baseline (adaptation disabled))",-0.184884,-0.42973,-0.627049,0,80,unavailable,42.8,16.2,6.9,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 3); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thymus: 6.9 nTPM (manageable, limit 5); thyroid gland: 6.3 nTPM (manageable, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); cerebellum: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3); urinary bladder: 4.5 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132953,XPO4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.6111% (minimum 99%, Missing); amygdala: 97.2603% (minimum 99%, Missing); basal ganglia: 94.6667% (minimum 99%, Missing); bone marrow: 98.6111% (minimum 99%, Missing); cerebellum: 94.6667% (minimum 99%, Missing); cerebral cortex: 94.6667% (minimum 99%, Missing); choroid plexus: 97.2603% (minimum 99%, Missing); duodenum: 93.4211% (minimum 99%, Missing); hippocampal formation: 98.6111% (minimum 99%, Missing); hypothalamus: 97.2603% (minimum 99%, Missing); kidney: 98.6111% (minimum 99%, Missing); liver: 98.6111% (minimum 99%, Missing); lymph node: 95.9459% (minimum 97%, Missing); midbrain: 98.6111% (minimum 99%, Missing); pituitary gland: 98.6111% (minimum 99%, Missing); retina: 93.4211% (minimum 99%, Missing); skeletal muscle: 95.9459% (minimum 99%, Missing); small intestine: 93.4211% (minimum 99%, Missing); smooth muscle: 98.6111% (minimum 99%, Missing); spinal cord: 98.6111% (minimum 99%, Missing)",0.0226027,-0.0105405,-0.0557895,0,80,unavailable,0.5,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132958,TPTE2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.322603,0.259459,0.184211,0,80,unavailable,0.5,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132958,TPTE2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.322603,0.259459,0.184211,0,80,unavailable,0.5,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132958,TPTE2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.322603,0.259459,0.184211,0,80,unavailable,0.5,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132958,TPTE2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.322603,0.259459,0.184211,0,80,unavailable,0.5,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132958,TPTE2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 98.7448% (minimum 99%, Missing)",0.05,0.0257806,-0.0025523,0,2,partial,0.3,0.1,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132972,RNF17,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.295781,0.237448,0,2,partial,0.3,0.1,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132972,RNF17,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.295781,0.237448,0,2,partial,0.3,0.1,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132972,RNF17,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.295781,0.237448,0,2,partial,0.3,0.1,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132972,RNF17,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.295781,0.237448,0,2,partial,0.3,0.1,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000132972,RNF17,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 91.4894% (minimum 99%, Missing); amygdala: 71.6667% (minimum 99%, Missing); basal ganglia: 74.1379% (minimum 99%, Missing); bone marrow: 95.5556% (minimum 98%, Approved); cerebral cortex: 30.7143% (minimum 99%, Missing); choroid plexus: 97.7273% (minimum 99%, Missing); colon: 39.0909% (minimum 97%, Missing); duodenum: 75.4386% (minimum 99%, Missing); esophagus: 37.3913% (minimum 97%, Missing); heart muscle: 91.4894% (minimum 98%, Approved); hippocampal formation: 67.1875% (minimum 99%, Missing); hypothalamus: 75.4386% (minimum 99%, Missing); kidney: 79.6296% (minimum 99%, Missing); liver: 91.4894% (minimum 99%, Missing); lung: 79.6296% (minimum 99%, Missing); midbrain: 91.4894% (minimum 99%, Missing); pancreas: 29.4521% (minimum 99%, Missing); parathyroid gland: 89.5833% (minimum 95%, Approved); pituitary gland: 89.5833% (minimum 99%, Missing); rectum: 60.5634% (minimum 97%, Missing); retina: 72.8814% (minimum 99%, Missing); salivary gland: 20.1878% (minimum 97%, Missing); skin: 78.1818% (minimum 95%, Missing); small intestine: 75.4386% (minimum 99%, Missing); smooth muscle: 51.8072% (minimum 99%, Missing); spinal cord: 95.5556% (minimum 99%, Missing); spleen: 86.0000% (minimum 90%, Approved); stomach: 46.7391% (minimum 97%, Missing); thyroid gland: 69.3548% (minimum 95%, Missing); urinary bladder: 38.7387% (minimum 97%, Missing)",-0.256452,-0.768122,-0.695479,0,2,partial,10.3,17,1.9,"salivary gland: 17 nTPM (protected, limit 2); pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); urinary bladder: 6.8 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133019,CHRM3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 71.6667% (minimum 75%, Missing); basal ganglia: 74.1379% (minimum 75%, Missing); cerebral cortex: 30.7143% (minimum 75%, Missing); colon: 39.0909% (minimum 70%, Missing); esophagus: 37.3913% (minimum 70%, Missing); hippocampal formation: 67.1875% (minimum 75%, Missing); pancreas: 29.4521% (minimum 75%, Missing); rectum: 60.5634% (minimum 70%, Missing); retina: 72.8814% (minimum 75%, Missing); salivary gland: 20.1878% (minimum 70%, Missing); smooth muscle: 51.8072% (minimum 75%, Missing); stomach: 46.7391% (minimum 70%, Missing); urinary bladder: 38.7387% (minimum 70%, Missing)",0.0435484,-0.498122,-0.455479,0,2,partial,10.3,17,1.9,"salivary gland: 17 nTPM (protected, limit 2); pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); urinary bladder: 6.8 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133019,CHRM3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 71.6667% (minimum 75%, Missing); basal ganglia: 74.1379% (minimum 75%, Missing); cerebral cortex: 30.7143% (minimum 75%, Missing); colon: 39.0909% (minimum 70%, Missing); esophagus: 37.3913% (minimum 70%, Missing); hippocampal formation: 67.1875% (minimum 75%, Missing); pancreas: 29.4521% (minimum 75%, Missing); rectum: 60.5634% (minimum 70%, Missing); retina: 72.8814% (minimum 75%, Missing); salivary gland: 20.1878% (minimum 70%, Missing); smooth muscle: 51.8072% (minimum 75%, Missing); stomach: 46.7391% (minimum 70%, Missing); urinary bladder: 38.7387% (minimum 70%, Missing)",0.0435484,-0.498122,-0.455479,0,2,partial,10.3,17,1.9,"salivary gland: 17 nTPM (protected, limit 3); pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); urinary bladder: 6.8 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); smooth muscle: 4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133019,CHRM3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 71.6667% (minimum 75%, Missing); basal ganglia: 74.1379% (minimum 75%, Missing); cerebral cortex: 30.7143% (minimum 75%, Missing); colon: 39.0909% (minimum 70%, Missing); esophagus: 37.3913% (minimum 70%, Missing); hippocampal formation: 67.1875% (minimum 75%, Missing); pancreas: 29.4521% (minimum 75%, Missing); rectum: 60.5634% (minimum 70%, Missing); retina: 72.8814% (minimum 75%, Missing); salivary gland: 20.1878% (minimum 70%, Missing); smooth muscle: 51.8072% (minimum 75%, Missing); stomach: 46.7391% (minimum 70%, Missing); urinary bladder: 38.7387% (minimum 70%, Missing)",0.0435484,-0.498122,-0.455479,0,2,partial,10.3,17,1.9,"salivary gland: 17 nTPM (protected, limit 3); pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); urinary bladder: 6.8 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); smooth muscle: 4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133019,CHRM3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 71.6667% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.1379% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 30.7143% (minimum 75%, Baseline (adaptation disabled)); colon: 39.0909% (minimum 70%, Baseline (adaptation disabled)); esophagus: 37.3913% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 67.1875% (minimum 75%, Baseline (adaptation disabled)); pancreas: 29.4521% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.5634% (minimum 70%, Baseline (adaptation disabled)); retina: 72.8814% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 20.1878% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 51.8072% (minimum 75%, Baseline (adaptation disabled)); stomach: 46.7391% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 38.7387% (minimum 70%, Baseline (adaptation disabled))",0.0435484,-0.498122,-0.455479,0,2,partial,10.3,17,1.9,"salivary gland: 17 nTPM (protected, limit 3); pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); urinary bladder: 6.8 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); smooth muscle: 4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133019,CHRM3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 92.8320% (minimum 99%, Missing); basal ganglia: 86.9087% (minimum 99%, Missing); cerebral cortex: 90.8046% (minimum 95%, Enhanced); choroid plexus: 90.5963% (minimum 99%, Missing); hippocampal formation: 91.4352% (minimum 99%, Missing); hypothalamus: 89.3665% (minimum 99%, Missing); midbrain: 96.1071% (minimum 99%, Missing); parathyroid gland: 78.6070% (minimum 80%, Enhanced); pituitary gland: 90.8046% (minimum 99%, Missing); retina: 98.8736% (minimum 99%, Missing); smooth muscle: 90.9091% (minimum 95%, Enhanced); spinal cord: 97.8934% (minimum 99%, Missing)",0.0449622,-0.0139303,-0.120913,0,4,partial,11.9,21.5,0.6,"parathyroid gland: 21.5 nTPM (protected, limit 12); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 6); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 6); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133101,CCNA1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344962,0.23607,0.119087,0,4,partial,11.9,21.5,0.6,"parathyroid gland: 21.5 nTPM (protected, limit 12); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 6); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 6); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133101,CCNA1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344962,0.23607,0.119087,0,4,partial,11.9,21.5,0.6,"parathyroid gland: 21.5 nTPM (protected, limit 12); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 6); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 6); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133101,CCNA1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344962,0.23607,0.119087,0,4,partial,11.9,21.5,0.6,"parathyroid gland: 21.5 nTPM (protected, limit 12); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 6); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 6); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133101,CCNA1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.342462,0.0860697,0.119087,0,4,partial,11.9,21.5,0.6,"parathyroid gland: 21.5 nTPM (protected, limit 3); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133101,CCNA1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.1111% (minimum 95%, Missing); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 61.1111% (minimum 99%, Missing); basal ganglia: 61.6822% (minimum 99%, Missing); bone marrow: 52.8000% (minimum 99%, Missing); cerebellum: 48.5294% (minimum 99%, Missing); cerebral cortex: 50.3817% (minimum 99%, Missing); choroid plexus: 77.6471% (minimum 99%, Missing); colon: 57.3913% (minimum 97%, Missing); duodenum: 68.7500% (minimum 99%, Missing); esophagus: 69.4737% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 61.6822% (minimum 99%, Missing); hypothalamus: 62.2642% (minimum 99%, Missing); kidney: 67.3469% (minimum 99%, Missing); liver: 72.5275% (minimum 99%, Missing); lung: 61.6822% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 61.6822% (minimum 99%, Missing); pancreas: 59.4595% (minimum 99%, Missing); parathyroid gland: 52.3810% (minimum 97%, Missing); pituitary gland: 59.4595% (minimum 99%, Missing); rectum: 62.2642% (minimum 97%, Missing); retina: 55.4622% (minimum 99%, Missing); salivary gland: 58.4071% (minimum 97%, Missing); skeletal muscle: 61.6822% (minimum 99%, Missing); skin: 66.0000% (minimum 95%, Missing); small intestine: 60.5505% (minimum 99%, Missing); smooth muscle: 54.5455% (minimum 99%, Missing); spinal cord: 57.3913% (minimum 99%, Missing); spleen: 57.3913% (minimum 95%, Missing); stomach: 61.6822% (minimum 97%, Missing); thymus: 45.2055% (minimum 95%, Missing); thyroid gland: 53.6585% (minimum 95%, Missing); tongue: 69.4737% (minimum 97%, Missing); urinary bladder: 62.8571% (minimum 97%, Missing)",-0.497945,-0.47,-0.504706,0,80,unavailable,7,6.6,8,"thymus: 8 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 2); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 2); spinal cord: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); basal ganglia: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); hypothalamus: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133111,RFXAP,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.1111% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 61.1111% (minimum 75%, Missing); basal ganglia: 61.6822% (minimum 75%, Missing); bone marrow: 52.8000% (minimum 75%, Missing); cerebellum: 48.5294% (minimum 75%, Missing); cerebral cortex: 50.3817% (minimum 75%, Missing); colon: 57.3913% (minimum 70%, Missing); duodenum: 68.7500% (minimum 75%, Missing); esophagus: 69.4737% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 61.6822% (minimum 75%, Missing); hypothalamus: 62.2642% (minimum 75%, Missing); kidney: 67.3469% (minimum 75%, Missing); liver: 72.5275% (minimum 75%, Missing); lung: 61.6822% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); midbrain: 61.6822% (minimum 75%, Missing); pancreas: 59.4595% (minimum 75%, Missing); parathyroid gland: 52.3810% (minimum 70%, Missing); pituitary gland: 59.4595% (minimum 75%, Missing); rectum: 62.2642% (minimum 70%, Missing); retina: 55.4622% (minimum 75%, Missing); salivary gland: 58.4071% (minimum 70%, Missing); skeletal muscle: 61.6822% (minimum 75%, Missing); small intestine: 60.5505% (minimum 75%, Missing); smooth muscle: 54.5455% (minimum 75%, Missing); spinal cord: 57.3913% (minimum 75%, Missing); spleen: 57.3913% (minimum 65%, Missing); stomach: 61.6822% (minimum 70%, Missing); thymus: 45.2055% (minimum 65%, Missing); thyroid gland: 53.6585% (minimum 65%, Missing); tongue: 69.4737% (minimum 70%, Missing); urinary bladder: 62.8571% (minimum 70%, Missing)",-0.197945,-0.2,-0.264706,0,80,unavailable,7,6.6,8,"thymus: 8 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 2); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 2); spinal cord: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); basal ganglia: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); hypothalamus: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133111,RFXAP,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.1111% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 61.1111% (minimum 75%, Missing); basal ganglia: 61.6822% (minimum 75%, Missing); bone marrow: 52.8000% (minimum 75%, Missing); cerebellum: 48.5294% (minimum 75%, Missing); cerebral cortex: 50.3817% (minimum 75%, Missing); colon: 57.3913% (minimum 70%, Missing); duodenum: 68.7500% (minimum 75%, Missing); esophagus: 69.4737% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 61.6822% (minimum 75%, Missing); hypothalamus: 62.2642% (minimum 75%, Missing); kidney: 67.3469% (minimum 75%, Missing); liver: 72.5275% (minimum 75%, Missing); lung: 61.6822% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); midbrain: 61.6822% (minimum 75%, Missing); pancreas: 59.4595% (minimum 75%, Missing); parathyroid gland: 52.3810% (minimum 70%, Missing); pituitary gland: 59.4595% (minimum 75%, Missing); rectum: 62.2642% (minimum 70%, Missing); retina: 55.4622% (minimum 75%, Missing); salivary gland: 58.4071% (minimum 70%, Missing); skeletal muscle: 61.6822% (minimum 75%, Missing); small intestine: 60.5505% (minimum 75%, Missing); smooth muscle: 54.5455% (minimum 75%, Missing); spinal cord: 57.3913% (minimum 75%, Missing); spleen: 57.3913% (minimum 65%, Missing); stomach: 61.6822% (minimum 70%, Missing); thymus: 45.2055% (minimum 65%, Missing); thyroid gland: 53.6585% (minimum 65%, Missing); tongue: 69.4737% (minimum 70%, Missing); urinary bladder: 62.8571% (minimum 70%, Missing)",-0.197945,-0.2,-0.264706,0,80,unavailable,7,6.6,8,"thymus: 8 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 3); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 3); salivary gland: 4.7 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); heart muscle: 3.3 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133111,RFXAP,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.1111% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 61.1111% (minimum 75%, Missing); basal ganglia: 61.6822% (minimum 75%, Missing); bone marrow: 52.8000% (minimum 75%, Missing); cerebellum: 48.5294% (minimum 75%, Missing); cerebral cortex: 50.3817% (minimum 75%, Missing); colon: 57.3913% (minimum 70%, Missing); duodenum: 68.7500% (minimum 75%, Missing); esophagus: 69.4737% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 61.6822% (minimum 75%, Missing); hypothalamus: 62.2642% (minimum 75%, Missing); kidney: 67.3469% (minimum 75%, Missing); liver: 72.5275% (minimum 75%, Missing); lung: 61.6822% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); midbrain: 61.6822% (minimum 75%, Missing); pancreas: 59.4595% (minimum 75%, Missing); parathyroid gland: 52.3810% (minimum 70%, Missing); pituitary gland: 59.4595% (minimum 75%, Missing); rectum: 62.2642% (minimum 70%, Missing); retina: 55.4622% (minimum 75%, Missing); salivary gland: 58.4071% (minimum 70%, Missing); skeletal muscle: 61.6822% (minimum 75%, Missing); small intestine: 60.5505% (minimum 75%, Missing); smooth muscle: 54.5455% (minimum 75%, Missing); spinal cord: 57.3913% (minimum 75%, Missing); spleen: 57.3913% (minimum 65%, Missing); stomach: 61.6822% (minimum 70%, Missing); thymus: 45.2055% (minimum 65%, Missing); thyroid gland: 53.6585% (minimum 65%, Missing); tongue: 69.4737% (minimum 70%, Missing); urinary bladder: 62.8571% (minimum 70%, Missing)",-0.197945,-0.2,-0.264706,0,80,unavailable,7,6.6,8,"thymus: 8 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 3); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 3); salivary gland: 4.7 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); heart muscle: 3.3 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133111,RFXAP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.1111% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); amygdala: 61.1111% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.6822% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 52.8000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.5294% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.3817% (minimum 75%, Baseline (adaptation disabled)); colon: 57.3913% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.7500% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.4737% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.6822% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.2642% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.3469% (minimum 75%, Baseline (adaptation disabled)); liver: 72.5275% (minimum 75%, Baseline (adaptation disabled)); lung: 61.6822% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); midbrain: 61.6822% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.4595% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.3810% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 59.4595% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.2642% (minimum 70%, Baseline (adaptation disabled)); retina: 55.4622% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.4071% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 61.6822% (minimum 75%, Baseline (adaptation disabled)); small intestine: 60.5505% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 54.5455% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.3913% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.3913% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.6822% (minimum 70%, Baseline (adaptation disabled)); thymus: 45.2055% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.6585% (minimum 65%, Baseline (adaptation disabled)); tongue: 69.4737% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.8571% (minimum 70%, Baseline (adaptation disabled))",-0.197945,-0.2,-0.264706,0,80,unavailable,7,6.6,8,"thymus: 8 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 3); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 3); salivary gland: 4.7 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); heart muscle: 3.3 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133111,RFXAP,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 88.4187% (minimum 97%, Missing); duodenum: 92.7570% (minimum 99%, Missing); esophagus: 66.8350% (minimum 80%, Enhanced); heart muscle: 95.4327% (minimum 99%, Missing); kidney: 91.0550% (minimum 99%, Missing); liver: 93.4118% (minimum 95%, Enhanced); pancreas: 75.1894% (minimum 95%, Enhanced); pituitary gland: 97.0660% (minimum 99%, Missing); rectum: 92.7570% (minimum 97%, Missing); small intestine: 84.2887% (minimum 99%, Missing); stomach: 85.7451% (minimum 97%, Missing); urinary bladder: 94.0758% (minimum 97%, Missing)",0.0302469,-0.13165,-0.198106,0,2,partial,13.1,19.7,18.2,"esophagus: 19.7 nTPM (protected, limit 12); pancreas: 13.1 nTPM (vital, limit 6); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133477,FAM83F,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.185665,0.11835,0.0928875,0,2,partial,13.1,19.7,18.2,"esophagus: 19.7 nTPM (protected, limit 12); pancreas: 13.1 nTPM (vital, limit 6); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133477,FAM83F,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.185665,0.11835,0.0928875,0,2,partial,13.1,19.7,18.2,"esophagus: 19.7 nTPM (protected, limit 12); pancreas: 13.1 nTPM (vital, limit 6); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133477,FAM83F,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.185665,0.11835,0.0928875,0,2,partial,13.1,19.7,18.2,"esophagus: 19.7 nTPM (protected, limit 12); pancreas: 13.1 nTPM (vital, limit 6); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133477,FAM83F,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 66.8350% (minimum 70%, Baseline (adaptation disabled))",0.0356649,-0.0316498,0.00189394,0,2,partial,13.1,19.7,18.2,"esophagus: 19.7 nTPM (protected, limit 3); skin: 18.2 nTPM (manageable, limit 5); pancreas: 13.1 nTPM (vital, limit 1); salivary gland: 8 nTPM (protected, limit 3); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); thyroid gland: 5.7 nTPM (manageable, limit 5); colon: 5.2 nTPM (protected, limit 3); parathyroid gland: 5.2 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); liver: 2.8 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133477,FAM83F,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5414% (minimum 99%, Missing); amygdala: 92.5926% (minimum 99%, Missing); basal ganglia: 89.2857% (minimum 99%, Missing); cerebral cortex: 96.7742% (minimum 99%, Missing); choroid plexus: 52.4476% (minimum 99%, Missing); heart muscle: 98.6842% (minimum 99%, Missing); hippocampal formation: 88.7574% (minimum 99%, Missing); hypothalamus: 87.2093% (minimum 99%, Missing); kidney: 88.7574% (minimum 99%, Missing); lung: 85.7143% (minimum 99%, Missing); midbrain: 95.5414% (minimum 99%, Missing); pancreas: 98.0392% (minimum 99%, Missing); parathyroid gland: 83.7989% (minimum 97%, Missing); pituitary gland: 92.0245% (minimum 99%, Missing); retina: 63.8298% (minimum 99%, Missing); smooth muscle: 96.1538% (minimum 99%, Missing); spinal cord: 96.7742% (minimum 99%, Missing); thyroid gland: 86.7052% (minimum 95%, Missing)",-0.082948,-0.132011,-0.465524,0,80,unavailable,13.6,2.9,2.3,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133640,LRRIQ1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 52.4476% (minimum 75%, Missing); retina: 63.8298% (minimum 75%, Missing)",0.217052,0.137989,-0.225524,0,80,unavailable,13.6,2.9,2.3,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133640,LRRIQ1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 52.4476% (minimum 75%, Missing); retina: 63.8298% (minimum 75%, Missing)",0.217052,0.137989,-0.225524,0,80,unavailable,13.6,2.9,2.3,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133640,LRRIQ1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 52.4476% (minimum 75%, Missing); retina: 63.8298% (minimum 75%, Missing)",0.217052,0.137989,-0.225524,0,80,unavailable,13.6,2.9,2.3,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133640,LRRIQ1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 52.4476% (minimum 75%, Baseline (adaptation disabled)); retina: 63.8298% (minimum 75%, Baseline (adaptation disabled))",0.217052,0.137989,-0.225524,0,80,unavailable,13.6,2.9,2.3,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133640,LRRIQ1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Missing); adrenal gland: 87.7470% (minimum 99%, Missing); amygdala: 72.6678% (minimum 99%, Missing); basal ganglia: 84.4106% (minimum 99%, Missing); bone marrow: 75.1269% (minimum 99%, Missing); cerebellum: 18.2042% (minimum 99%, Missing); cerebral cortex: 44.9848% (minimum 99%, Missing); choroid plexus: 76.2887% (minimum 99%, Missing); colon: 60.8219% (minimum 97%, Missing); duodenum: 76.8166% (minimum 99%, Missing); esophagus: 65.5835% (minimum 97%, Missing); heart muscle: 48.1040% (minimum 98%, Approved); hippocampal formation: 61.6667% (minimum 99%, Missing); hypothalamus: 87.5740% (minimum 99%, Missing); kidney: 92.3077% (minimum 99%, Missing); liver: 89.5161% (minimum 99%, Missing); lung: 64.2547% (minimum 99%, Missing); lymph node: 90.7975% (minimum 97%, Missing); midbrain: 92.5000% (minimum 99%, Missing); pancreas: 86.7188% (minimum 99%, Missing); parathyroid gland: 96.3124% (minimum 97%, Missing); pituitary gland: 97.5824% (minimum 99%, Missing); rectum: 62.9787% (minimum 97%, Missing); retina: 91.5464% (minimum 99%, Missing); salivary gland: 95.4839% (minimum 97%, Missing); skeletal muscle: 66.5667% (minimum 99%, Missing); skin: 74.6218% (minimum 95%, Missing); small intestine: 71.0400% (minimum 99%, Missing); smooth muscle: 49.3882% (minimum 99%, Missing); spinal cord: 84.0909% (minimum 99%, Missing); stomach: 80.1444% (minimum 97%, Missing); thymus: 91.9255% (minimum 95%, Missing); thyroid gland: 83.6158% (minimum 95%, Missing); tongue: 90.0609% (minimum 97%, Missing); urinary bladder: 71.3826% (minimum 97%, Missing)",-0.203782,-0.361781,-0.807958,0,2,partial,199.5,28.6,15.1,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 2); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 2); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 2); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 2); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 2); amygdala: 16.7 nTPM (vital, limit 1); skin: 15.1 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 2); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133816,MICAL2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.6678% (minimum 75%, Missing); cerebellum: 18.2042% (minimum 75%, Missing); cerebral cortex: 44.9848% (minimum 75%, Missing); colon: 60.8219% (minimum 70%, Missing); esophagus: 65.5835% (minimum 70%, Missing); heart muscle: 48.1040% (minimum 70%, Approved); hippocampal formation: 61.6667% (minimum 75%, Missing); lung: 64.2547% (minimum 75%, Missing); rectum: 62.9787% (minimum 70%, Missing); skeletal muscle: 66.5667% (minimum 75%, Missing); small intestine: 71.0400% (minimum 75%, Missing); smooth muscle: 49.3882% (minimum 75%, Missing)",0.0962185,-0.0917808,-0.567958,0,2,partial,199.5,28.6,15.1,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 2); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 2); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 2); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 2); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 2); amygdala: 16.7 nTPM (vital, limit 1); skin: 15.1 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 2); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133816,MICAL2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.6678% (minimum 75%, Missing); cerebellum: 18.2042% (minimum 75%, Missing); cerebral cortex: 44.9848% (minimum 75%, Missing); colon: 60.8219% (minimum 70%, Missing); esophagus: 65.5835% (minimum 70%, Missing); heart muscle: 48.1040% (minimum 70%, Approved); hippocampal formation: 61.6667% (minimum 75%, Missing); lung: 64.2547% (minimum 75%, Missing); rectum: 62.9787% (minimum 70%, Missing); skeletal muscle: 66.5667% (minimum 75%, Missing); small intestine: 71.0400% (minimum 75%, Missing); smooth muscle: 49.3882% (minimum 75%, Missing)",0.0962185,-0.0917808,-0.567958,0,2,partial,199.5,28.6,15.1,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 2); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 3); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 3); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 3); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 3); amygdala: 16.7 nTPM (vital, limit 1); skin: 15.1 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 3); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133816,MICAL2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.6678% (minimum 75%, Missing); cerebellum: 18.2042% (minimum 75%, Missing); cerebral cortex: 44.9848% (minimum 75%, Missing); colon: 60.8219% (minimum 70%, Missing); esophagus: 65.5835% (minimum 70%, Missing); heart muscle: 48.1040% (minimum 70%, Approved); hippocampal formation: 61.6667% (minimum 75%, Missing); lung: 64.2547% (minimum 75%, Missing); rectum: 62.9787% (minimum 70%, Missing); skeletal muscle: 66.5667% (minimum 75%, Missing); small intestine: 71.0400% (minimum 75%, Missing); smooth muscle: 49.3882% (minimum 75%, Missing)",0.0962185,-0.0917808,-0.567958,0,2,partial,199.5,28.6,15.1,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 2); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 3); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 3); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 3); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 3); amygdala: 16.7 nTPM (vital, limit 1); skin: 15.1 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 3); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133816,MICAL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.6678% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 18.2042% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 44.9848% (minimum 75%, Baseline (adaptation disabled)); colon: 60.8219% (minimum 70%, Baseline (adaptation disabled)); esophagus: 65.5835% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 48.1040% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.6667% (minimum 75%, Baseline (adaptation disabled)); lung: 64.2547% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.9787% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 66.5667% (minimum 75%, Baseline (adaptation disabled)); small intestine: 71.0400% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 49.3882% (minimum 75%, Baseline (adaptation disabled))",0.0962185,-0.0917808,-0.567958,0,2,partial,199.5,28.6,15.1,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 1); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 3); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 3); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 3); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 3); amygdala: 16.7 nTPM (vital, limit 1); skin: 15.1 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 3); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133816,MICAL2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.5207% (minimum 99%, Missing); basal ganglia: 95.1613% (minimum 99%, Missing); hippocampal formation: 98.3333% (minimum 99%, Missing); hypothalamus: 98.3333% (minimum 99%, Missing); pituitary gland: 95.1613% (minimum 99%, Missing); smooth muscle: 69.8225% (minimum 95%, Enhanced)",0.05,0.03,-0.251775,0,3,partial,5.1,0.4,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133863,TEX15,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0982249,0,3,partial,5.1,0.4,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133863,TEX15,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0982249,0,3,partial,5.1,0.4,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133863,TEX15,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0982249,0,3,partial,5.1,0.4,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133863,TEX15,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"smooth muscle: 69.8225% (minimum 75%, Baseline (adaptation disabled))",0.333333,0.267213,-0.0517751,0,3,partial,5.1,0.4,0.2,"smooth muscle: 5.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133863,TEX15,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 83.3333% (minimum 99%, Missing); bone marrow: 76.9231% (minimum 99%, Missing); cerebral cortex: 76.9231% (minimum 99%, Missing); colon: 62.5000% (minimum 97%, Missing); duodenum: 76.9231% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 71.4286% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 90.9091% (minimum 99%, Missing); lung: 62.5000% (minimum 99%, Missing); lymph node: 52.6316% (minimum 97%, Missing); pancreas: 8.7719% (minimum 99%, Missing); parathyroid gland: 76.9231% (minimum 97%, Missing); pituitary gland: 83.3333% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 58.8235% (minimum 99%, Missing); salivary gland: 29.4118% (minimum 97%, Missing); skeletal muscle: 47.6190% (minimum 99%, Missing); skin: 31.2500% (minimum 95%, Missing); small intestine: 52.6316% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spleen: 62.5000% (minimum 95%, Missing); stomach: 41.6667% (minimum 97%, Missing); thymus: 76.9231% (minimum 95%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); urinary bladder: 83.3333% (minimum 97%, Missing)",-0.6375,-0.675882,-0.902281,0,80,unavailable,10.4,2.4,2.2,"pancreas: 10.4 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133962,CATSPERB,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 62.5000% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); lung: 62.5000% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); pancreas: 8.7719% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 58.8235% (minimum 75%, Missing); salivary gland: 29.4118% (minimum 70%, Missing); skeletal muscle: 47.6190% (minimum 75%, Missing); skin: 31.2500% (minimum 65%, Missing); small intestine: 52.6316% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 41.6667% (minimum 70%, Missing)",-0.3375,-0.405882,-0.662281,0,80,unavailable,10.4,2.4,2.2,"pancreas: 10.4 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133962,CATSPERB,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 62.5000% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); lung: 62.5000% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); pancreas: 8.7719% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 58.8235% (minimum 75%, Missing); salivary gland: 29.4118% (minimum 70%, Missing); skeletal muscle: 47.6190% (minimum 75%, Missing); skin: 31.2500% (minimum 65%, Missing); small intestine: 52.6316% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 41.6667% (minimum 70%, Missing)",-0.3375,-0.405882,-0.662281,0,80,unavailable,10.4,2.4,2.2,"pancreas: 10.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133962,CATSPERB,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 62.5000% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); lung: 62.5000% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); pancreas: 8.7719% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 58.8235% (minimum 75%, Missing); salivary gland: 29.4118% (minimum 70%, Missing); skeletal muscle: 47.6190% (minimum 75%, Missing); skin: 31.2500% (minimum 65%, Missing); small intestine: 52.6316% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 41.6667% (minimum 70%, Missing)",-0.3375,-0.405882,-0.662281,0,80,unavailable,10.4,2.4,2.2,"pancreas: 10.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133962,CATSPERB,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 62.5000% (minimum 70%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); lung: 62.5000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.6316% (minimum 70%, Baseline (adaptation disabled)); pancreas: 8.7719% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 58.8235% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 29.4118% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 47.6190% (minimum 75%, Baseline (adaptation disabled)); skin: 31.2500% (minimum 65%, Baseline (adaptation disabled)); small intestine: 52.6316% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 65%, Baseline (adaptation disabled)); stomach: 41.6667% (minimum 70%, Baseline (adaptation disabled))",-0.3375,-0.405882,-0.662281,0,80,unavailable,10.4,2.4,2.2,"pancreas: 10.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133962,CATSPERB,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 94.1176% (minimum 99%, Missing); colon: 94.1176% (minimum 97%, Missing); duodenum: 88.8889% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); small intestine: 88.8889% (minimum 99%, Missing); spleen: 94.1176% (minimum 95%, Missing); stomach: 94.1176% (minimum 97%, Missing); tongue: 94.1176% (minimum 97%, Missing)",-0.00882353,-0.17,-0.101111,0,80,unavailable,0.2,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133980,VRTN,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.291176,0.1,0.138889,0,80,unavailable,0.2,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133980,VRTN,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.291176,0.1,0.138889,0,80,unavailable,0.2,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133980,VRTN,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.291176,0.1,0.138889,0,80,unavailable,0.2,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133980,VRTN,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.291176,0.1,0.138889,0,80,unavailable,0.2,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000133980,VRTN,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.0769% (minimum 99%, Missing); cerebellum: 92.7273% (minimum 95%, Enhanced); hippocampal formation: 98.0769% (minimum 99%, Missing); hypothalamus: 98.0769% (minimum 99%, Missing); pituitary gland: 98.0769% (minimum 99%, Missing); retina: 92.7273% (minimum 99%, Missing)",0.05,0.03,-0.0627273,0,1,partial,0.4,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134007,ADAM20,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.177273,0,1,partial,0.4,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134007,ADAM20,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.177273,0,1,partial,0.4,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134007,ADAM20,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.177273,0,1,partial,0.4,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134007,ADAM20,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.330769,0.280769,0.177273,0,1,partial,0.4,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134007,ADAM20,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1593% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); amygdala: 79.6875% (minimum 99%, Missing); basal ganglia: 76.3092% (minimum 99%, Missing); bone marrow: 60.3550% (minimum 99%, Missing); cerebellum: 75.1843% (minimum 99%, Missing); cerebral cortex: 78.4615% (minimum 99%, Missing); choroid plexus: 79.8956% (minimum 99%, Missing); colon: 64.6934% (minimum 97%, Missing); duodenum: 72.3404% (minimum 99%, Missing); esophagus: 51.6020% (minimum 97%, Missing); heart muscle: 68.0000% (minimum 99%, Missing); hippocampal formation: 80.5263% (minimum 99%, Missing); hypothalamus: 79.6875% (minimum 99%, Missing); kidney: 65.3846% (minimum 99%, Missing); liver: 65.1064% (minimum 99%, Missing); lung: 65.8065% (minimum 99%, Missing); lymph node: 49.4346% (minimum 97%, Missing); midbrain: 76.3092% (minimum 99%, Missing); pancreas: 64.4211% (minimum 99%, Missing); parathyroid gland: 65.8065% (minimum 97%, Missing); pituitary gland: 77.2727% (minimum 99%, Missing); rectum: 65.8065% (minimum 97%, Missing); retina: 68.9189% (minimum 99%, Missing); salivary gland: 61.9433% (minimum 97%, Missing); skeletal muscle: 67.2527% (minimum 99%, Missing); skin: 55.2347% (minimum 95%, Missing); small intestine: 66.9584% (minimum 99%, Missing); smooth muscle: 72.6841% (minimum 99%, Missing); spinal cord: 77.0781% (minimum 99%, Missing); spleen: 59.7656% (minimum 95%, Missing); stomach: 69.2308% (minimum 97%, Missing); thymus: 61.0778% (minimum 95%, Missing); thyroid gland: 50.4119% (minimum 95%, Missing); tongue: 65.5246% (minimum 97%, Missing); urinary bladder: 60.2362% (minimum 97%, Missing)",-0.445881,-0.475654,-0.38645,0,4,partial,20.1,31.3,30.1,"lymph node: 31.3 nTPM (protected, limit 2); thyroid gland: 30.1 nTPM (manageable, limit 5); esophagus: 28.7 nTPM (protected, limit 2); adipose tissue: 25.9 nTPM (manageable, limit 5); skin: 24.8 nTPM (manageable, limit 5); spleen: 20.6 nTPM (manageable, limit 5); urinary bladder: 20.2 nTPM (protected, limit 2); bone marrow: 20.1 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); salivary gland: 18.8 nTPM (protected, limit 2); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 2); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); parathyroid gland: 15.9 nTPM (protected, limit 2); rectum: 15.9 nTPM (protected, limit 2); lung: 15.9 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 2); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134046,MBD2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1593% (minimum 65%, Missing); bone marrow: 60.3550% (minimum 75%, Missing); colon: 64.6934% (minimum 70%, Missing); duodenum: 72.3404% (minimum 75%, Missing); esophagus: 51.6020% (minimum 70%, Missing); heart muscle: 68.0000% (minimum 75%, Missing); kidney: 65.3846% (minimum 75%, Missing); liver: 65.1064% (minimum 75%, Missing); lung: 65.8065% (minimum 75%, Missing); lymph node: 49.4346% (minimum 70%, Missing); pancreas: 64.4211% (minimum 75%, Missing); parathyroid gland: 65.8065% (minimum 70%, Missing); rectum: 65.8065% (minimum 70%, Missing); retina: 68.9189% (minimum 75%, Missing); salivary gland: 61.9433% (minimum 70%, Missing); skeletal muscle: 67.2527% (minimum 75%, Missing); skin: 55.2347% (minimum 65%, Missing); small intestine: 66.9584% (minimum 75%, Missing); smooth muscle: 72.6841% (minimum 75%, Missing); spleen: 59.7656% (minimum 65%, Missing); stomach: 69.2308% (minimum 70%, Missing); thymus: 61.0778% (minimum 65%, Missing); thyroid gland: 50.4119% (minimum 65%, Missing); tongue: 65.5246% (minimum 70%, Missing); urinary bladder: 60.2362% (minimum 70%, Missing)",-0.145881,-0.205654,-0.14645,0,4,partial,20.1,31.3,30.1,"lymph node: 31.3 nTPM (protected, limit 2); thyroid gland: 30.1 nTPM (manageable, limit 5); esophagus: 28.7 nTPM (protected, limit 2); adipose tissue: 25.9 nTPM (manageable, limit 5); skin: 24.8 nTPM (manageable, limit 5); spleen: 20.6 nTPM (manageable, limit 5); urinary bladder: 20.2 nTPM (protected, limit 2); bone marrow: 20.1 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); salivary gland: 18.8 nTPM (protected, limit 2); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 2); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); parathyroid gland: 15.9 nTPM (protected, limit 2); rectum: 15.9 nTPM (protected, limit 2); lung: 15.9 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 2); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134046,MBD2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1593% (minimum 65%, Missing); bone marrow: 60.3550% (minimum 75%, Missing); colon: 64.6934% (minimum 70%, Missing); duodenum: 72.3404% (minimum 75%, Missing); esophagus: 51.6020% (minimum 70%, Missing); heart muscle: 68.0000% (minimum 75%, Missing); kidney: 65.3846% (minimum 75%, Missing); liver: 65.1064% (minimum 75%, Missing); lung: 65.8065% (minimum 75%, Missing); lymph node: 49.4346% (minimum 70%, Missing); pancreas: 64.4211% (minimum 75%, Missing); parathyroid gland: 65.8065% (minimum 70%, Missing); rectum: 65.8065% (minimum 70%, Missing); retina: 68.9189% (minimum 75%, Missing); salivary gland: 61.9433% (minimum 70%, Missing); skeletal muscle: 67.2527% (minimum 75%, Missing); skin: 55.2347% (minimum 65%, Missing); small intestine: 66.9584% (minimum 75%, Missing); smooth muscle: 72.6841% (minimum 75%, Missing); spleen: 59.7656% (minimum 65%, Missing); stomach: 69.2308% (minimum 70%, Missing); thymus: 61.0778% (minimum 65%, Missing); thyroid gland: 50.4119% (minimum 65%, Missing); tongue: 65.5246% (minimum 70%, Missing); urinary bladder: 60.2362% (minimum 70%, Missing)",-0.145881,-0.205654,-0.14645,0,4,partial,20.1,31.3,30.1,"lymph node: 31.3 nTPM (protected, limit 3); thyroid gland: 30.1 nTPM (manageable, limit 5); esophagus: 28.7 nTPM (protected, limit 3); adipose tissue: 25.9 nTPM (manageable, limit 5); skin: 24.8 nTPM (manageable, limit 5); spleen: 20.6 nTPM (manageable, limit 5); urinary bladder: 20.2 nTPM (protected, limit 3); bone marrow: 20.1 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); salivary gland: 18.8 nTPM (protected, limit 3); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 3); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); parathyroid gland: 15.9 nTPM (protected, limit 3); rectum: 15.9 nTPM (protected, limit 3); lung: 15.9 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 3); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134046,MBD2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1593% (minimum 65%, Missing); bone marrow: 60.3550% (minimum 75%, Missing); colon: 64.6934% (minimum 70%, Missing); duodenum: 72.3404% (minimum 75%, Missing); esophagus: 51.6020% (minimum 70%, Missing); heart muscle: 68.0000% (minimum 75%, Missing); kidney: 65.3846% (minimum 75%, Missing); liver: 65.1064% (minimum 75%, Missing); lung: 65.8065% (minimum 75%, Missing); lymph node: 49.4346% (minimum 70%, Missing); pancreas: 64.4211% (minimum 75%, Missing); parathyroid gland: 65.8065% (minimum 70%, Missing); rectum: 65.8065% (minimum 70%, Missing); retina: 68.9189% (minimum 75%, Missing); salivary gland: 61.9433% (minimum 70%, Missing); skeletal muscle: 67.2527% (minimum 75%, Missing); skin: 55.2347% (minimum 65%, Missing); small intestine: 66.9584% (minimum 75%, Missing); smooth muscle: 72.6841% (minimum 75%, Missing); spleen: 59.7656% (minimum 65%, Missing); stomach: 69.2308% (minimum 70%, Missing); thymus: 61.0778% (minimum 65%, Missing); thyroid gland: 50.4119% (minimum 65%, Missing); tongue: 65.5246% (minimum 70%, Missing); urinary bladder: 60.2362% (minimum 70%, Missing)",-0.145881,-0.205654,-0.14645,0,4,partial,20.1,31.3,30.1,"lymph node: 31.3 nTPM (protected, limit 3); thyroid gland: 30.1 nTPM (manageable, limit 5); esophagus: 28.7 nTPM (protected, limit 3); adipose tissue: 25.9 nTPM (manageable, limit 5); skin: 24.8 nTPM (manageable, limit 5); spleen: 20.6 nTPM (manageable, limit 5); urinary bladder: 20.2 nTPM (protected, limit 3); bone marrow: 20.1 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); salivary gland: 18.8 nTPM (protected, limit 3); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 3); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); parathyroid gland: 15.9 nTPM (protected, limit 3); rectum: 15.9 nTPM (protected, limit 3); lung: 15.9 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 3); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134046,MBD2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1593% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 60.3550% (minimum 75%, Baseline (adaptation disabled)); colon: 64.6934% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.3404% (minimum 75%, Baseline (adaptation disabled)); esophagus: 51.6020% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.3846% (minimum 75%, Baseline (adaptation disabled)); liver: 65.1064% (minimum 75%, Baseline (adaptation disabled)); lung: 65.8065% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.4346% (minimum 70%, Baseline (adaptation disabled)); pancreas: 64.4211% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.8065% (minimum 70%, Baseline (adaptation disabled)); rectum: 65.8065% (minimum 70%, Baseline (adaptation disabled)); retina: 68.9189% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.9433% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 67.2527% (minimum 75%, Baseline (adaptation disabled)); skin: 55.2347% (minimum 65%, Baseline (adaptation disabled)); small intestine: 66.9584% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.6841% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.7656% (minimum 65%, Baseline (adaptation disabled)); stomach: 69.2308% (minimum 70%, Baseline (adaptation disabled)); thymus: 61.0778% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.4119% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.5246% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.2362% (minimum 70%, Baseline (adaptation disabled))",-0.145881,-0.205654,-0.14645,0,4,partial,20.1,31.3,30.1,"lymph node: 31.3 nTPM (protected, limit 3); thyroid gland: 30.1 nTPM (manageable, limit 5); esophagus: 28.7 nTPM (protected, limit 3); adipose tissue: 25.9 nTPM (manageable, limit 5); skin: 24.8 nTPM (manageable, limit 5); spleen: 20.6 nTPM (manageable, limit 5); urinary bladder: 20.2 nTPM (protected, limit 3); bone marrow: 20.1 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); salivary gland: 18.8 nTPM (protected, limit 3); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 3); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); parathyroid gland: 15.9 nTPM (protected, limit 3); rectum: 15.9 nTPM (protected, limit 3); lung: 15.9 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 3); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134046,MBD2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.9294% (minimum 95%, Missing); adrenal gland: 45.0658% (minimum 99%, Missing); amygdala: 64.0187% (minimum 99%, Missing); basal ganglia: 64.3192% (minimum 99%, Missing); bone marrow: 48.9286% (minimum 99%, Missing); cerebellum: 48.9286% (minimum 99%, Missing); cerebral cortex: 62.2727% (minimum 99%, Missing); choroid plexus: 47.5694% (minimum 99%, Missing); colon: 50.1832% (minimum 97%, Missing); duodenum: 45.3642% (minimum 99%, Missing); esophagus: 53.9370% (minimum 97%, Missing); heart muscle: 45.6667% (minimum 99%, Missing); hippocampal formation: 64.6226% (minimum 99%, Missing); hypothalamus: 59.0517% (minimum 99%, Missing); kidney: 31.1364% (minimum 99%, Missing); liver: 42.0245% (minimum 99%, Missing); lung: 53.5156% (minimum 99%, Missing); lymph node: 55.2419% (minimum 97%, Missing); midbrain: 64.0187% (minimum 99%, Missing); pancreas: 50.9294% (minimum 99%, Missing); parathyroid gland: 42.5466% (minimum 97%, Missing); pituitary gland: 47.5694% (minimum 99%, Missing); rectum: 52.0913% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 48.4099% (minimum 97%, Missing); skeletal muscle: 31.3501% (minimum 99%, Missing); skin: 50.5535% (minimum 95%, Missing); small intestine: 47.2414% (minimum 99%, Missing); smooth muscle: 59.8253% (minimum 97%, Supported); spinal cord: 64.9289% (minimum 99%, Missing); spleen: 55.9184% (minimum 95%, Missing); stomach: 46.9178% (minimum 97%, Missing); thymus: 55.9184% (minimum 95%, Missing); thyroid gland: 47.0790% (minimum 95%, Missing); tongue: 39.5954% (minimum 97%, Missing); urinary bladder: 50.5535% (minimum 97%, Missing)",-0.47921,-0.574046,-0.678636,0,13,partial,30.3,20.9,15.4,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 2); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 2); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 2); thyroid gland: 15.4 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); salivary gland: 14.6 nTPM (protected, limit 2); cerebellum: 14.3 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); urinary bladder: 13.4 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); pancreas: 13.2 nTPM (vital, limit 1); rectum: 12.6 nTPM (protected, limit 2); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 2); lymph node: 11.1 nTPM (protected, limit 2); spleen: 10.8 nTPM (manageable, limit 5); thymus: 10.8 nTPM (manageable, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 3); cerebral cortex: 8.3 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),97,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134049,IER3IP1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.9294% (minimum 65%, Missing); adrenal gland: 45.0658% (minimum 75%, Missing); amygdala: 64.0187% (minimum 75%, Missing); basal ganglia: 64.3192% (minimum 75%, Missing); bone marrow: 48.9286% (minimum 75%, Missing); cerebellum: 48.9286% (minimum 75%, Missing); cerebral cortex: 62.2727% (minimum 75%, Missing); choroid plexus: 47.5694% (minimum 75%, Missing); colon: 50.1832% (minimum 70%, Missing); duodenum: 45.3642% (minimum 75%, Missing); esophagus: 53.9370% (minimum 70%, Missing); heart muscle: 45.6667% (minimum 75%, Missing); hippocampal formation: 64.6226% (minimum 75%, Missing); hypothalamus: 59.0517% (minimum 75%, Missing); kidney: 31.1364% (minimum 75%, Missing); liver: 42.0245% (minimum 75%, Missing); lung: 53.5156% (minimum 75%, Missing); lymph node: 55.2419% (minimum 70%, Missing); midbrain: 64.0187% (minimum 75%, Missing); pancreas: 50.9294% (minimum 75%, Missing); parathyroid gland: 42.5466% (minimum 70%, Missing); pituitary gland: 47.5694% (minimum 75%, Missing); rectum: 52.0913% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 48.4099% (minimum 70%, Missing); skeletal muscle: 31.3501% (minimum 75%, Missing); skin: 50.5535% (minimum 65%, Missing); small intestine: 47.2414% (minimum 75%, Missing); smooth muscle: 59.8253% (minimum 65%, Supported); spinal cord: 64.9289% (minimum 75%, Missing); spleen: 55.9184% (minimum 65%, Missing); stomach: 46.9178% (minimum 70%, Missing); thymus: 55.9184% (minimum 65%, Missing); thyroid gland: 47.0790% (minimum 65%, Missing); tongue: 39.5954% (minimum 70%, Missing); urinary bladder: 50.5535% (minimum 70%, Missing)",-0.17921,-0.304046,-0.438636,0,13,partial,30.3,20.9,15.4,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 2); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 2); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 2); thyroid gland: 15.4 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); salivary gland: 14.6 nTPM (protected, limit 2); cerebellum: 14.3 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); urinary bladder: 13.4 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); pancreas: 13.2 nTPM (vital, limit 1); rectum: 12.6 nTPM (protected, limit 2); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 2); lymph node: 11.1 nTPM (protected, limit 2); spleen: 10.8 nTPM (manageable, limit 5); thymus: 10.8 nTPM (manageable, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 3); cerebral cortex: 8.3 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),97,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134049,IER3IP1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.9294% (minimum 65%, Missing); adrenal gland: 45.0658% (minimum 75%, Missing); amygdala: 64.0187% (minimum 75%, Missing); basal ganglia: 64.3192% (minimum 75%, Missing); bone marrow: 48.9286% (minimum 75%, Missing); cerebellum: 48.9286% (minimum 75%, Missing); cerebral cortex: 62.2727% (minimum 75%, Missing); choroid plexus: 47.5694% (minimum 75%, Missing); colon: 50.1832% (minimum 70%, Missing); duodenum: 45.3642% (minimum 75%, Missing); esophagus: 53.9370% (minimum 70%, Missing); heart muscle: 45.6667% (minimum 75%, Missing); hippocampal formation: 64.6226% (minimum 75%, Missing); hypothalamus: 59.0517% (minimum 75%, Missing); kidney: 31.1364% (minimum 75%, Missing); liver: 42.0245% (minimum 75%, Missing); lung: 53.5156% (minimum 75%, Missing); lymph node: 55.2419% (minimum 70%, Missing); midbrain: 64.0187% (minimum 75%, Missing); pancreas: 50.9294% (minimum 75%, Missing); parathyroid gland: 42.5466% (minimum 70%, Missing); pituitary gland: 47.5694% (minimum 75%, Missing); rectum: 52.0913% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 48.4099% (minimum 70%, Missing); skeletal muscle: 31.3501% (minimum 75%, Missing); skin: 50.5535% (minimum 65%, Missing); small intestine: 47.2414% (minimum 75%, Missing); smooth muscle: 59.8253% (minimum 65%, Supported); spinal cord: 64.9289% (minimum 75%, Missing); spleen: 55.9184% (minimum 65%, Missing); stomach: 46.9178% (minimum 70%, Missing); thymus: 55.9184% (minimum 65%, Missing); thyroid gland: 47.0790% (minimum 65%, Missing); tongue: 39.5954% (minimum 70%, Missing); urinary bladder: 50.5535% (minimum 70%, Missing)",-0.17921,-0.304046,-0.438636,0,13,partial,30.3,20.9,15.4,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 3); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 3); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 3); thyroid gland: 15.4 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); salivary gland: 14.6 nTPM (protected, limit 3); cerebellum: 14.3 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); urinary bladder: 13.4 nTPM (protected, limit 3); adipose tissue: 13.2 nTPM (manageable, limit 5); pancreas: 13.2 nTPM (vital, limit 1); rectum: 12.6 nTPM (protected, limit 3); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 3); lymph node: 11.1 nTPM (protected, limit 3); spleen: 10.8 nTPM (manageable, limit 5); thymus: 10.8 nTPM (manageable, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 3); cerebral cortex: 8.3 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),97,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134049,IER3IP1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.9294% (minimum 65%, Missing); adrenal gland: 45.0658% (minimum 75%, Missing); amygdala: 64.0187% (minimum 75%, Missing); basal ganglia: 64.3192% (minimum 75%, Missing); bone marrow: 48.9286% (minimum 75%, Missing); cerebellum: 48.9286% (minimum 75%, Missing); cerebral cortex: 62.2727% (minimum 75%, Missing); choroid plexus: 47.5694% (minimum 75%, Missing); colon: 50.1832% (minimum 70%, Missing); duodenum: 45.3642% (minimum 75%, Missing); esophagus: 53.9370% (minimum 70%, Missing); heart muscle: 45.6667% (minimum 75%, Missing); hippocampal formation: 64.6226% (minimum 75%, Missing); hypothalamus: 59.0517% (minimum 75%, Missing); kidney: 31.1364% (minimum 75%, Missing); liver: 42.0245% (minimum 75%, Missing); lung: 53.5156% (minimum 75%, Missing); lymph node: 55.2419% (minimum 70%, Missing); midbrain: 64.0187% (minimum 75%, Missing); pancreas: 50.9294% (minimum 75%, Missing); parathyroid gland: 42.5466% (minimum 70%, Missing); pituitary gland: 47.5694% (minimum 75%, Missing); rectum: 52.0913% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 48.4099% (minimum 70%, Missing); skeletal muscle: 31.3501% (minimum 75%, Missing); skin: 50.5535% (minimum 65%, Missing); small intestine: 47.2414% (minimum 75%, Missing); smooth muscle: 59.8253% (minimum 65%, Supported); spinal cord: 64.9289% (minimum 75%, Missing); spleen: 55.9184% (minimum 65%, Missing); stomach: 46.9178% (minimum 70%, Missing); thymus: 55.9184% (minimum 65%, Missing); thyroid gland: 47.0790% (minimum 65%, Missing); tongue: 39.5954% (minimum 70%, Missing); urinary bladder: 50.5535% (minimum 70%, Missing)",-0.17921,-0.304046,-0.438636,0,13,partial,30.3,20.9,15.4,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 3); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 3); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 3); thyroid gland: 15.4 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); salivary gland: 14.6 nTPM (protected, limit 3); cerebellum: 14.3 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); urinary bladder: 13.4 nTPM (protected, limit 3); adipose tissue: 13.2 nTPM (manageable, limit 5); pancreas: 13.2 nTPM (vital, limit 1); rectum: 12.6 nTPM (protected, limit 3); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 3); lymph node: 11.1 nTPM (protected, limit 3); spleen: 10.8 nTPM (manageable, limit 5); thymus: 10.8 nTPM (manageable, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 3); cerebral cortex: 8.3 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),97,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134049,IER3IP1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.9294% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 45.0658% (minimum 75%, Baseline (adaptation disabled)); amygdala: 64.0187% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.3192% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 48.9286% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.9286% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.2727% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 47.5694% (minimum 75%, Baseline (adaptation disabled)); colon: 50.1832% (minimum 70%, Baseline (adaptation disabled)); duodenum: 45.3642% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.9370% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 45.6667% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.6226% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 59.0517% (minimum 75%, Baseline (adaptation disabled)); kidney: 31.1364% (minimum 75%, Baseline (adaptation disabled)); liver: 42.0245% (minimum 75%, Baseline (adaptation disabled)); lung: 53.5156% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.2419% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.0187% (minimum 75%, Baseline (adaptation disabled)); pancreas: 50.9294% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 42.5466% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 47.5694% (minimum 75%, Baseline (adaptation disabled)); rectum: 52.0913% (minimum 70%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 48.4099% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 31.3501% (minimum 75%, Baseline (adaptation disabled)); skin: 50.5535% (minimum 65%, Baseline (adaptation disabled)); small intestine: 47.2414% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.8253% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.9289% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.9184% (minimum 65%, Baseline (adaptation disabled)); stomach: 46.9178% (minimum 70%, Baseline (adaptation disabled)); thymus: 55.9184% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 47.0790% (minimum 65%, Baseline (adaptation disabled)); tongue: 39.5954% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 50.5535% (minimum 70%, Baseline (adaptation disabled))",-0.17921,-0.304046,-0.438636,0,13,partial,30.3,20.9,15.4,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 3); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 3); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 3); thyroid gland: 15.4 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); salivary gland: 14.6 nTPM (protected, limit 3); cerebellum: 14.3 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); urinary bladder: 13.4 nTPM (protected, limit 3); adipose tissue: 13.2 nTPM (manageable, limit 5); pancreas: 13.2 nTPM (vital, limit 1); rectum: 12.6 nTPM (protected, limit 3); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 3); lymph node: 11.1 nTPM (protected, limit 3); spleen: 10.8 nTPM (manageable, limit 5); thymus: 10.8 nTPM (manageable, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),97,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134049,IER3IP1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.3158% (minimum 95%, Missing); adrenal gland: 59.7765% (minimum 99%, Missing); amygdala: 72.2973% (minimum 99%, Missing); basal ganglia: 71.3333% (minimum 99%, Missing); bone marrow: 66.4596% (minimum 98%, Approved); cerebellum: 75.3521% (minimum 98%, Approved); cerebral cortex: 66.8750% (minimum 99%, Missing); choroid plexus: 68.5897% (minimum 99%, Missing); colon: 62.2093% (minimum 97%, Missing); duodenum: 63.6905% (minimum 99%, Missing); esophagus: 53.7688% (minimum 95%, Approved); heart muscle: 52.1951% (minimum 99%, Missing); hippocampal formation: 73.7931% (minimum 99%, Missing); hypothalamus: 73.2877% (minimum 99%, Missing); kidney: 51.4423% (minimum 99%, Missing); liver: 57.8378% (minimum 99%, Missing); lung: 67.2956% (minimum 99%, Missing); lymph node: 67.7215% (minimum 95%, Approved); midbrain: 68.5897% (minimum 99%, Missing); pancreas: 43.6735% (minimum 99%, Missing); parathyroid gland: 56.0209% (minimum 97%, Missing); pituitary gland: 65.2439% (minimum 99%, Missing); rectum: 61.1429% (minimum 97%, Missing); retina: 55.4404% (minimum 99%, Missing); salivary gland: 62.2093% (minimum 97%, Missing); skeletal muscle: 50.7109% (minimum 99%, Missing); skin: 53.2338% (minimum 90%, Approved); small intestine: 62.5731% (minimum 99%, Missing); smooth muscle: 63.3136% (minimum 98%, Approved); spinal cord: 63.6905% (minimum 99%, Missing); spleen: 63.3136% (minimum 90%, Approved); stomach: 62.2093% (minimum 97%, Missing); thymus: 61.1429% (minimum 95%, Missing); thyroid gland: 50.4717% (minimum 95%, Missing); tongue: 61.8497% (minimum 97%, Missing); urinary bladder: 57.8378% (minimum 97%, Missing)",-0.445283,-0.412312,-0.553265,0,2,partial,13.8,9.2,10.5,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (manageable, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); esophagus: 9.2 nTPM (protected, limit 4); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 2); adipose tissue: 8.3 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 2); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 2); thymus: 6.8 nTPM (manageable, limit 5); tongue: 6.6 nTPM (protected, limit 2); salivary gland: 6.5 nTPM (protected, limit 2); colon: 6.5 nTPM (protected, limit 2); stomach: 6.5 nTPM (protected, limit 2); small intestine: 6.4 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 2); spinal cord: 6.1 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 2); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 4); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134146,DPH6,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.3158% (minimum 65%, Missing); adrenal gland: 59.7765% (minimum 75%, Missing); amygdala: 72.2973% (minimum 75%, Missing); basal ganglia: 71.3333% (minimum 75%, Missing); bone marrow: 66.4596% (minimum 70%, Approved); cerebral cortex: 66.8750% (minimum 75%, Missing); choroid plexus: 68.5897% (minimum 75%, Missing); colon: 62.2093% (minimum 70%, Missing); duodenum: 63.6905% (minimum 75%, Missing); esophagus: 53.7688% (minimum 65%, Approved); heart muscle: 52.1951% (minimum 75%, Missing); hippocampal formation: 73.7931% (minimum 75%, Missing); hypothalamus: 73.2877% (minimum 75%, Missing); kidney: 51.4423% (minimum 75%, Missing); liver: 57.8378% (minimum 75%, Missing); lung: 67.2956% (minimum 75%, Missing); midbrain: 68.5897% (minimum 75%, Missing); pancreas: 43.6735% (minimum 75%, Missing); parathyroid gland: 56.0209% (minimum 70%, Missing); pituitary gland: 65.2439% (minimum 75%, Missing); rectum: 61.1429% (minimum 70%, Missing); retina: 55.4404% (minimum 75%, Missing); salivary gland: 62.2093% (minimum 70%, Missing); skeletal muscle: 50.7109% (minimum 75%, Missing); skin: 53.2338% (minimum 60%, Approved); small intestine: 62.5731% (minimum 75%, Missing); smooth muscle: 63.3136% (minimum 70%, Approved); spinal cord: 63.6905% (minimum 75%, Missing); stomach: 62.2093% (minimum 70%, Missing); thymus: 61.1429% (minimum 65%, Missing); thyroid gland: 50.4717% (minimum 65%, Missing); tongue: 61.8497% (minimum 70%, Missing); urinary bladder: 57.8378% (minimum 70%, Missing)",-0.145283,-0.139791,-0.313265,0,2,partial,13.8,9.2,10.5,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (manageable, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); esophagus: 9.2 nTPM (protected, limit 4); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 2); adipose tissue: 8.3 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 2); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 2); thymus: 6.8 nTPM (manageable, limit 5); tongue: 6.6 nTPM (protected, limit 2); salivary gland: 6.5 nTPM (protected, limit 2); colon: 6.5 nTPM (protected, limit 2); stomach: 6.5 nTPM (protected, limit 2); small intestine: 6.4 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 2); spinal cord: 6.1 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 2); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 4); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134146,DPH6,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.3158% (minimum 65%, Missing); adrenal gland: 59.7765% (minimum 75%, Missing); amygdala: 72.2973% (minimum 75%, Missing); basal ganglia: 71.3333% (minimum 75%, Missing); bone marrow: 66.4596% (minimum 70%, Approved); cerebral cortex: 66.8750% (minimum 75%, Missing); choroid plexus: 68.5897% (minimum 75%, Missing); colon: 62.2093% (minimum 70%, Missing); duodenum: 63.6905% (minimum 75%, Missing); esophagus: 53.7688% (minimum 65%, Approved); heart muscle: 52.1951% (minimum 75%, Missing); hippocampal formation: 73.7931% (minimum 75%, Missing); hypothalamus: 73.2877% (minimum 75%, Missing); kidney: 51.4423% (minimum 75%, Missing); liver: 57.8378% (minimum 75%, Missing); lung: 67.2956% (minimum 75%, Missing); midbrain: 68.5897% (minimum 75%, Missing); pancreas: 43.6735% (minimum 75%, Missing); parathyroid gland: 56.0209% (minimum 70%, Missing); pituitary gland: 65.2439% (minimum 75%, Missing); rectum: 61.1429% (minimum 70%, Missing); retina: 55.4404% (minimum 75%, Missing); salivary gland: 62.2093% (minimum 70%, Missing); skeletal muscle: 50.7109% (minimum 75%, Missing); skin: 53.2338% (minimum 60%, Approved); small intestine: 62.5731% (minimum 75%, Missing); smooth muscle: 63.3136% (minimum 70%, Approved); spinal cord: 63.6905% (minimum 75%, Missing); stomach: 62.2093% (minimum 70%, Missing); thymus: 61.1429% (minimum 65%, Missing); thyroid gland: 50.4717% (minimum 65%, Missing); tongue: 61.8497% (minimum 70%, Missing); urinary bladder: 57.8378% (minimum 70%, Missing)",-0.145283,-0.139791,-0.313265,0,2,partial,13.8,9.2,10.5,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (manageable, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); esophagus: 9.2 nTPM (protected, limit 4); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 3); adipose tissue: 8.3 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 3); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 3); thymus: 6.8 nTPM (manageable, limit 5); tongue: 6.6 nTPM (protected, limit 3); salivary gland: 6.5 nTPM (protected, limit 3); colon: 6.5 nTPM (protected, limit 3); stomach: 6.5 nTPM (protected, limit 3); small intestine: 6.4 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 2); spinal cord: 6.1 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 2); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 4); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134146,DPH6,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.3158% (minimum 65%, Missing); adrenal gland: 59.7765% (minimum 75%, Missing); amygdala: 72.2973% (minimum 75%, Missing); basal ganglia: 71.3333% (minimum 75%, Missing); bone marrow: 66.4596% (minimum 70%, Approved); cerebral cortex: 66.8750% (minimum 75%, Missing); choroid plexus: 68.5897% (minimum 75%, Missing); colon: 62.2093% (minimum 70%, Missing); duodenum: 63.6905% (minimum 75%, Missing); esophagus: 53.7688% (minimum 65%, Approved); heart muscle: 52.1951% (minimum 75%, Missing); hippocampal formation: 73.7931% (minimum 75%, Missing); hypothalamus: 73.2877% (minimum 75%, Missing); kidney: 51.4423% (minimum 75%, Missing); liver: 57.8378% (minimum 75%, Missing); lung: 67.2956% (minimum 75%, Missing); midbrain: 68.5897% (minimum 75%, Missing); pancreas: 43.6735% (minimum 75%, Missing); parathyroid gland: 56.0209% (minimum 70%, Missing); pituitary gland: 65.2439% (minimum 75%, Missing); rectum: 61.1429% (minimum 70%, Missing); retina: 55.4404% (minimum 75%, Missing); salivary gland: 62.2093% (minimum 70%, Missing); skeletal muscle: 50.7109% (minimum 75%, Missing); skin: 53.2338% (minimum 60%, Approved); small intestine: 62.5731% (minimum 75%, Missing); smooth muscle: 63.3136% (minimum 70%, Approved); spinal cord: 63.6905% (minimum 75%, Missing); stomach: 62.2093% (minimum 70%, Missing); thymus: 61.1429% (minimum 65%, Missing); thyroid gland: 50.4717% (minimum 65%, Missing); tongue: 61.8497% (minimum 70%, Missing); urinary bladder: 57.8378% (minimum 70%, Missing)",-0.145283,-0.139791,-0.313265,0,2,partial,13.8,9.2,10.5,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (manageable, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); esophagus: 9.2 nTPM (protected, limit 4); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 3); adipose tissue: 8.3 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 3); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 3); thymus: 6.8 nTPM (manageable, limit 5); tongue: 6.6 nTPM (protected, limit 3); salivary gland: 6.5 nTPM (protected, limit 3); colon: 6.5 nTPM (protected, limit 3); stomach: 6.5 nTPM (protected, limit 3); small intestine: 6.4 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 2); spinal cord: 6.1 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 2); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 4); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134146,DPH6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.3158% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 59.7765% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.2973% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.3333% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.4596% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.8750% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.5897% (minimum 75%, Baseline (adaptation disabled)); colon: 62.2093% (minimum 70%, Baseline (adaptation disabled)); duodenum: 63.6905% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.7688% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.1951% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.7931% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.2877% (minimum 75%, Baseline (adaptation disabled)); kidney: 51.4423% (minimum 75%, Baseline (adaptation disabled)); liver: 57.8378% (minimum 75%, Baseline (adaptation disabled)); lung: 67.2956% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.7215% (minimum 70%, Baseline (adaptation disabled)); midbrain: 68.5897% (minimum 75%, Baseline (adaptation disabled)); pancreas: 43.6735% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 56.0209% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 65.2439% (minimum 75%, Baseline (adaptation disabled)); rectum: 61.1429% (minimum 70%, Baseline (adaptation disabled)); retina: 55.4404% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.2093% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 50.7109% (minimum 75%, Baseline (adaptation disabled)); skin: 53.2338% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.5731% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.3136% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.6905% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.3136% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.2093% (minimum 70%, Baseline (adaptation disabled)); thymus: 61.1429% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.4717% (minimum 65%, Baseline (adaptation disabled)); tongue: 61.8497% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.8378% (minimum 70%, Baseline (adaptation disabled))",-0.145283,-0.162312,-0.313265,0,2,partial,13.8,9.2,10.5,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (manageable, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.4 nTPM (manageable, limit 5); esophagus: 9.2 nTPM (protected, limit 3); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 3); adipose tissue: 8.3 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 3); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 3); thymus: 6.8 nTPM (manageable, limit 5); tongue: 6.6 nTPM (protected, limit 3); salivary gland: 6.5 nTPM (protected, limit 3); colon: 6.5 nTPM (protected, limit 3); stomach: 6.5 nTPM (protected, limit 3); small intestine: 6.4 nTPM (vital, limit 1); spleen: 6.2 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134146,DPH6,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 91.3043% (minimum 99%, Missing); choroid plexus: 95.4545% (minimum 99%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); midbrain: 75.0000% (minimum 99%, Missing); retina: 10.9948% (minimum 99%, Missing); skin: 30.8824% (minimum 60%, Enhanced); spinal cord: 72.4138% (minimum 99%, Missing)",-0.291176,0.03,-0.880052,0,2,partial,17,0.1,4.7,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),62,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134160,TRPM1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 10.9948% (minimum 75%, Missing); skin: 30.8824% (minimum 50%, Enhanced); spinal cord: 72.4138% (minimum 75%, Missing)",-0.191176,0.3,-0.640052,0,2,partial,17,0.1,4.7,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),62,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134160,TRPM1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 10.9948% (minimum 75%, Missing); skin: 30.8824% (minimum 50%, Enhanced); spinal cord: 72.4138% (minimum 75%, Missing)",-0.191176,0.3,-0.640052,0,2,partial,17,0.1,4.7,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),62,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134160,TRPM1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 10.9948% (minimum 75%, Missing); skin: 30.8824% (minimum 50%, Enhanced); spinal cord: 72.4138% (minimum 75%, Missing)",-0.191176,0.3,-0.640052,0,2,partial,17,0.1,4.7,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),62,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134160,TRPM1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 10.9948% (minimum 75%, Baseline (adaptation disabled)); skin: 30.8824% (minimum 65%, Baseline (adaptation disabled)); spinal cord: 72.4138% (minimum 75%, Baseline (adaptation disabled))",-0.341176,0.254545,-0.640052,0,2,partial,17,0.1,4.7,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),62,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134160,TRPM1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.7127% (minimum 95%, Missing); adrenal gland: 95.1289% (minimum 99%, Missing); amygdala: 95.6772% (minimum 99%, Missing); basal ganglia: 94.0510% (minimum 99%, Missing); bone marrow: 63.4799% (minimum 99%, Missing); cerebellum: 92.4791% (minimum 99%, Missing); cerebral cortex: 93.7853% (minimum 99%, Missing); choroid plexus: 83.2080% (minimum 99%, Missing); colon: 45.4172% (minimum 97%, Missing); duodenum: 78.6730% (minimum 99%, Missing); esophagus: 49.5522% (minimum 97%, Uncertain); heart muscle: 95.6772% (minimum 99%, Uncertain); hippocampal formation: 97.0760% (minimum 99%, Missing); hypothalamus: 95.1289% (minimum 99%, Missing); kidney: 29.0718% (minimum 99%, Missing); liver: 93.5211% (minimum 99%, Missing); lung: 89.4879% (minimum 99%, Missing); lymph node: 76.6744% (minimum 97%, Missing); midbrain: 89.9729% (minimum 99%, Missing); pancreas: 66.4000% (minimum 99%, Missing); parathyroid gland: 95.6772% (minimum 97%, Missing); pituitary gland: 96.2319% (minimum 99%, Missing); rectum: 40.2913% (minimum 97%, Missing); retina: 82.3821% (minimum 99%, Missing); salivary gland: 82.3821% (minimum 97%, Missing); skeletal muscle: 97.3607% (minimum 99%, Uncertain); skin: 41.0383% (minimum 95%, Missing); small intestine: 69.1667% (minimum 99%, Missing); smooth muscle: 90.4632% (minimum 99%, Uncertain); spinal cord: 98.2249% (minimum 99%, Missing); spleen: 75.2834% (minimum 95%, Missing); stomach: 82.3821% (minimum 97%, Missing); thymus: 79.4258% (minimum 95%, Missing); thyroid gland: 77.5701% (minimum 95%, Missing); tongue: 96.5116% (minimum 97%, Missing); urinary bladder: 72.9670% (minimum 97%, Missing)",-0.539617,-0.567087,-0.699282,0,7,partial,81,49.2,47.7,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 2); skin: 47.7 nTPM (manageable, limit 5); colon: 39.9 nTPM (protected, limit 2); esophagus: 33.8 nTPM (protected, limit 2); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 2); spleen: 10.9 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 2); thyroid gland: 9.6 nTPM (manageable, limit 5); duodenum: 9 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); retina: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); salivary gland: 7.1 nTPM (protected, limit 2); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134215,VAV3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.4799% (minimum 75%, Missing); colon: 45.4172% (minimum 70%, Missing); esophagus: 49.5522% (minimum 70%, Uncertain); kidney: 29.0718% (minimum 75%, Missing); pancreas: 66.4000% (minimum 75%, Missing); rectum: 40.2913% (minimum 70%, Missing); skin: 41.0383% (minimum 65%, Missing); small intestine: 69.1667% (minimum 75%, Missing)",-0.239617,-0.297087,-0.459282,0,7,partial,81,49.2,47.7,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 2); skin: 47.7 nTPM (manageable, limit 5); colon: 39.9 nTPM (protected, limit 2); esophagus: 33.8 nTPM (protected, limit 2); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 2); spleen: 10.9 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 2); thyroid gland: 9.6 nTPM (manageable, limit 5); duodenum: 9 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); retina: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); salivary gland: 7.1 nTPM (protected, limit 2); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134215,VAV3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.4799% (minimum 75%, Missing); colon: 45.4172% (minimum 70%, Missing); esophagus: 49.5522% (minimum 70%, Uncertain); kidney: 29.0718% (minimum 75%, Missing); pancreas: 66.4000% (minimum 75%, Missing); rectum: 40.2913% (minimum 70%, Missing); skin: 41.0383% (minimum 65%, Missing); small intestine: 69.1667% (minimum 75%, Missing)",-0.239617,-0.297087,-0.459282,0,7,partial,81,49.2,47.7,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 3); skin: 47.7 nTPM (manageable, limit 5); colon: 39.9 nTPM (protected, limit 3); esophagus: 33.8 nTPM (protected, limit 3); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 3); spleen: 10.9 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 3); thyroid gland: 9.6 nTPM (manageable, limit 5); duodenum: 9 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); retina: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); salivary gland: 7.1 nTPM (protected, limit 3); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134215,VAV3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.4799% (minimum 75%, Missing); colon: 45.4172% (minimum 70%, Missing); esophagus: 49.5522% (minimum 70%, Uncertain); kidney: 29.0718% (minimum 75%, Missing); pancreas: 66.4000% (minimum 75%, Missing); rectum: 40.2913% (minimum 70%, Missing); skin: 41.0383% (minimum 65%, Missing); small intestine: 69.1667% (minimum 75%, Missing)",-0.239617,-0.297087,-0.459282,0,7,partial,81,49.2,47.7,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 3); skin: 47.7 nTPM (manageable, limit 5); colon: 39.9 nTPM (protected, limit 3); esophagus: 33.8 nTPM (protected, limit 3); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 3); spleen: 10.9 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 3); thyroid gland: 9.6 nTPM (manageable, limit 5); duodenum: 9 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); retina: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); salivary gland: 7.1 nTPM (protected, limit 3); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134215,VAV3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.4799% (minimum 75%, Baseline (adaptation disabled)); colon: 45.4172% (minimum 70%, Baseline (adaptation disabled)); esophagus: 49.5522% (minimum 70%, Baseline (adaptation disabled)); kidney: 29.0718% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.4000% (minimum 75%, Baseline (adaptation disabled)); rectum: 40.2913% (minimum 70%, Baseline (adaptation disabled)); skin: 41.0383% (minimum 65%, Baseline (adaptation disabled)); small intestine: 69.1667% (minimum 75%, Baseline (adaptation disabled))",-0.239617,-0.297087,-0.459282,0,7,partial,81,49.2,47.7,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 3); skin: 47.7 nTPM (manageable, limit 5); colon: 39.9 nTPM (protected, limit 3); esophagus: 33.8 nTPM (protected, limit 3); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 3); spleen: 10.9 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 3); thyroid gland: 9.6 nTPM (manageable, limit 5); duodenum: 9 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); retina: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); salivary gland: 7.1 nTPM (protected, limit 3); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134215,VAV3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134249,ADAM30,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134249,ADAM30,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134249,ADAM30,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134249,ADAM30,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134249,ADAM30,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 90%, Approved); adrenal gland: 46.1538% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 11.3208% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 85.7143% (minimum 99%, Missing); colon: 25.0000% (minimum 97%, Missing); duodenum: 14.6341% (minimum 99%, Missing); esophagus: 40.0000% (minimum 97%, Missing); heart muscle: 60.0000% (minimum 99%, Missing); hippocampal formation: 85.7143% (minimum 99%, Missing); hypothalamus: 85.7143% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 50.0000% (minimum 99%, Missing); lung: 8.4507% (minimum 99%, Missing); lymph node: 24.0000% (minimum 97%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 42.8571% (minimum 99%, Missing); pituitary gland: 85.7143% (minimum 99%, Missing); rectum: 20.6897% (minimum 97%, Missing); retina: 85.7143% (minimum 99%, Missing); salivary gland: 28.5714% (minimum 97%, Missing); skeletal muscle: 85.7143% (minimum 99%, Missing); skin: 40.0000% (minimum 95%, Missing); small intestine: 8.9552% (minimum 99%, Missing); smooth muscle: 31.5789% (minimum 99%, Missing); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 16.2162% (minimum 90%, Approved); stomach: 30.0000% (minimum 97%, Missing); thymus: 33.3333% (minimum 95%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); urinary bladder: 33.3333% (minimum 95%, Approved)",-0.737838,-0.763103,-0.905493,0,2,partial,6.5,2.3,3.1,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134256,CD101,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 46.1538% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 11.3208% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 25.0000% (minimum 70%, Missing); duodenum: 14.6341% (minimum 75%, Missing); esophagus: 40.0000% (minimum 70%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Missing); lung: 8.4507% (minimum 75%, Missing); lymph node: 24.0000% (minimum 70%, Missing); pancreas: 42.8571% (minimum 75%, Missing); rectum: 20.6897% (minimum 70%, Missing); salivary gland: 28.5714% (minimum 70%, Missing); skin: 40.0000% (minimum 65%, Missing); small intestine: 8.9552% (minimum 75%, Missing); smooth muscle: 31.5789% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 16.2162% (minimum 60%, Approved); stomach: 30.0000% (minimum 70%, Missing); thymus: 33.3333% (minimum 65%, Missing); urinary bladder: 33.3333% (minimum 65%, Approved)",-0.437838,-0.493103,-0.665493,0,2,partial,6.5,2.3,3.1,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134256,CD101,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 46.1538% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 11.3208% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 25.0000% (minimum 70%, Missing); duodenum: 14.6341% (minimum 75%, Missing); esophagus: 40.0000% (minimum 70%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Missing); lung: 8.4507% (minimum 75%, Missing); lymph node: 24.0000% (minimum 70%, Missing); pancreas: 42.8571% (minimum 75%, Missing); rectum: 20.6897% (minimum 70%, Missing); salivary gland: 28.5714% (minimum 70%, Missing); skin: 40.0000% (minimum 65%, Missing); small intestine: 8.9552% (minimum 75%, Missing); smooth muscle: 31.5789% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 16.2162% (minimum 60%, Approved); stomach: 30.0000% (minimum 70%, Missing); thymus: 33.3333% (minimum 65%, Missing); urinary bladder: 33.3333% (minimum 65%, Approved)",-0.437838,-0.493103,-0.665493,0,2,partial,6.5,2.3,3.1,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134256,CD101,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 46.1538% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 11.3208% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 25.0000% (minimum 70%, Missing); duodenum: 14.6341% (minimum 75%, Missing); esophagus: 40.0000% (minimum 70%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Missing); lung: 8.4507% (minimum 75%, Missing); lymph node: 24.0000% (minimum 70%, Missing); pancreas: 42.8571% (minimum 75%, Missing); rectum: 20.6897% (minimum 70%, Missing); salivary gland: 28.5714% (minimum 70%, Missing); skin: 40.0000% (minimum 65%, Missing); small intestine: 8.9552% (minimum 75%, Missing); smooth muscle: 31.5789% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 16.2162% (minimum 60%, Approved); stomach: 30.0000% (minimum 70%, Missing); thymus: 33.3333% (minimum 65%, Missing); urinary bladder: 33.3333% (minimum 65%, Approved)",-0.437838,-0.493103,-0.665493,0,2,partial,6.5,2.3,3.1,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134256,CD101,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 46.1538% (minimum 75%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 11.3208% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); colon: 25.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 14.6341% (minimum 75%, Baseline (adaptation disabled)); esophagus: 40.0000% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 50.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 8.4507% (minimum 75%, Baseline (adaptation disabled)); lymph node: 24.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 42.8571% (minimum 75%, Baseline (adaptation disabled)); rectum: 20.6897% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 28.5714% (minimum 70%, Baseline (adaptation disabled)); skin: 40.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 8.9552% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 31.5789% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 16.2162% (minimum 65%, Baseline (adaptation disabled)); stomach: 30.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 33.3333% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 33.3333% (minimum 70%, Baseline (adaptation disabled))",-0.487838,-0.493103,-0.665493,0,2,partial,6.5,2.3,3.1,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134256,CD101,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.5517% (minimum 98%, Approved); amygdala: 19.4444% (minimum 99%, Missing); basal ganglia: 19.1781% (minimum 99%, Missing); bone marrow: 87.5000% (minimum 98%, Approved); cerebellum: 22.7642% (minimum 98%, Approved); cerebral cortex: 19.1781% (minimum 98%, Approved); choroid plexus: 80.0000% (minimum 99%, Missing); heart muscle: 96.5517% (minimum 98%, Approved); hippocampal formation: 22.4000% (minimum 99%, Missing); hypothalamus: 30.1075% (minimum 99%, Missing); kidney: 96.5517% (minimum 98%, Approved); lung: 96.5517% (minimum 98%, Approved); midbrain: 38.8889% (minimum 99%, Missing); pancreas: 90.3226% (minimum 98%, Approved); pituitary gland: 57.1429% (minimum 99%, Missing); retina: 3.7234% (minimum 99%, Missing); skeletal muscle: 82.3529% (minimum 98%, Approved); spinal cord: 43.7500% (minimum 99%, Missing); stomach: 93.3333% (minimum 95%, Approved); tongue: 87.5000% (minimum 97%, Missing)",0.0333333,-0.095,-0.952766,0,0,routine_complete,72.4,0.4,0.2,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 2); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 2); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),63,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134376,CRB1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 19.4444% (minimum 75%, Missing); basal ganglia: 19.1781% (minimum 75%, Missing); cerebellum: 22.7642% (minimum 70%, Approved); cerebral cortex: 19.1781% (minimum 70%, Approved); hippocampal formation: 22.4000% (minimum 75%, Missing); hypothalamus: 30.1075% (minimum 75%, Missing); midbrain: 38.8889% (minimum 75%, Missing); pituitary gland: 57.1429% (minimum 75%, Missing); retina: 3.7234% (minimum 75%, Missing); spinal cord: 43.7500% (minimum 75%, Missing)",0.333333,0.175,-0.712766,0,0,routine_complete,72.4,0.4,0.2,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 2); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 2); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),63,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134376,CRB1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 19.4444% (minimum 75%, Missing); basal ganglia: 19.1781% (minimum 75%, Missing); cerebellum: 22.7642% (minimum 70%, Approved); cerebral cortex: 19.1781% (minimum 70%, Approved); hippocampal formation: 22.4000% (minimum 75%, Missing); hypothalamus: 30.1075% (minimum 75%, Missing); midbrain: 38.8889% (minimum 75%, Missing); pituitary gland: 57.1429% (minimum 75%, Missing); retina: 3.7234% (minimum 75%, Missing); spinal cord: 43.7500% (minimum 75%, Missing)",0.333333,0.175,-0.712766,0,0,routine_complete,72.4,0.4,0.2,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 2); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 2); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),63,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134376,CRB1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 19.4444% (minimum 75%, Missing); basal ganglia: 19.1781% (minimum 75%, Missing); cerebellum: 22.7642% (minimum 70%, Approved); cerebral cortex: 19.1781% (minimum 70%, Approved); hippocampal formation: 22.4000% (minimum 75%, Missing); hypothalamus: 30.1075% (minimum 75%, Missing); midbrain: 38.8889% (minimum 75%, Missing); pituitary gland: 57.1429% (minimum 75%, Missing); retina: 3.7234% (minimum 75%, Missing); spinal cord: 43.7500% (minimum 75%, Missing)",0.333333,0.175,-0.712766,0,0,routine_complete,72.4,0.4,0.2,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 2); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 2); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),63,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134376,CRB1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 19.4444% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 19.1781% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 22.7642% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 19.1781% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 22.4000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 30.1075% (minimum 75%, Baseline (adaptation disabled)); midbrain: 38.8889% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 57.1429% (minimum 75%, Baseline (adaptation disabled)); retina: 3.7234% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 43.7500% (minimum 75%, Baseline (adaptation disabled))",0.283333,0.175,-0.712766,0,0,routine_complete,72.4,0.4,0.2,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),63,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134376,CRB1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,1,partial,162,0,0,"liver: 162 nTPM (vital, limit 3)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134389,CFHR5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,1,partial,162,0,0,"liver: 162 nTPM (vital, limit 3)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134389,CFHR5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,1,partial,162,0,0,"liver: 162 nTPM (vital, limit 3)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134389,CFHR5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,1,partial,162,0,0,"liver: 162 nTPM (vital, limit 3)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134389,CFHR5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,1,partial,162,0,0,"liver: 162 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134389,CFHR5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.3810% (minimum 95%, Missing); adrenal gland: 78.5714% (minimum 99%, Missing); amygdala: 78.5714% (minimum 99%, Missing); basal ganglia: 68.7500% (minimum 99%, Missing); bone marrow: 66.6667% (minimum 99%, Missing); cerebellum: 91.6667% (minimum 99%, Missing); cerebral cortex: 45.8333% (minimum 99%, Missing); choroid plexus: 95.6522% (minimum 99%, Missing); colon: 57.8947% (minimum 97%, Missing); duodenum: 59.4595% (minimum 99%, Missing); esophagus: 57.8947% (minimum 97%, Missing); heart muscle: 59.4595% (minimum 99%, Missing); hippocampal formation: 78.5714% (minimum 99%, Missing); hypothalamus: 75.8621% (minimum 99%, Missing); kidney: 68.7500% (minimum 99%, Missing); liver: 57.8947% (minimum 99%, Missing); lung: 61.1111% (minimum 99%, Missing); lymph node: 61.1111% (minimum 97%, Missing); midbrain: 81.4815% (minimum 99%, Missing); pancreas: 64.7059% (minimum 99%, Missing); parathyroid gland: 48.8889% (minimum 97%, Missing); pituitary gland: 68.7500% (minimum 99%, Missing); rectum: 50.0000% (minimum 97%, Missing); retina: 88.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 68.7500% (minimum 99%, Missing); skin: 73.3333% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); smooth muscle: 44.0000% (minimum 99%, Missing); spinal cord: 78.5714% (minimum 99%, Missing); spleen: 61.1111% (minimum 95%, Missing); stomach: 61.1111% (minimum 97%, Missing); thymus: 68.7500% (minimum 95%, Missing); thyroid gland: 51.1628% (minimum 95%, Missing); tongue: 73.3333% (minimum 97%, Missing); urinary bladder: 59.4595% (minimum 97%, Missing)",-0.438372,-0.481111,-0.55,0,80,unavailable,2.8,2.3,2.1,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134490,TMEM241,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.3810% (minimum 65%, Missing); basal ganglia: 68.7500% (minimum 75%, Missing); bone marrow: 66.6667% (minimum 75%, Missing); cerebral cortex: 45.8333% (minimum 75%, Missing); colon: 57.8947% (minimum 70%, Missing); duodenum: 59.4595% (minimum 75%, Missing); esophagus: 57.8947% (minimum 70%, Missing); heart muscle: 59.4595% (minimum 75%, Missing); kidney: 68.7500% (minimum 75%, Missing); liver: 57.8947% (minimum 75%, Missing); lung: 61.1111% (minimum 75%, Missing); lymph node: 61.1111% (minimum 70%, Missing); pancreas: 64.7059% (minimum 75%, Missing); parathyroid gland: 48.8889% (minimum 70%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); rectum: 50.0000% (minimum 70%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 68.7500% (minimum 75%, Missing); small intestine: 66.6667% (minimum 75%, Missing); smooth muscle: 44.0000% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); stomach: 61.1111% (minimum 70%, Missing); thyroid gland: 51.1628% (minimum 65%, Missing); urinary bladder: 59.4595% (minimum 70%, Missing)",-0.138372,-0.211111,-0.31,0,80,unavailable,2.8,2.3,2.1,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134490,TMEM241,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.3810% (minimum 65%, Missing); basal ganglia: 68.7500% (minimum 75%, Missing); bone marrow: 66.6667% (minimum 75%, Missing); cerebral cortex: 45.8333% (minimum 75%, Missing); colon: 57.8947% (minimum 70%, Missing); duodenum: 59.4595% (minimum 75%, Missing); esophagus: 57.8947% (minimum 70%, Missing); heart muscle: 59.4595% (minimum 75%, Missing); kidney: 68.7500% (minimum 75%, Missing); liver: 57.8947% (minimum 75%, Missing); lung: 61.1111% (minimum 75%, Missing); lymph node: 61.1111% (minimum 70%, Missing); pancreas: 64.7059% (minimum 75%, Missing); parathyroid gland: 48.8889% (minimum 70%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); rectum: 50.0000% (minimum 70%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 68.7500% (minimum 75%, Missing); small intestine: 66.6667% (minimum 75%, Missing); smooth muscle: 44.0000% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); stomach: 61.1111% (minimum 70%, Missing); thyroid gland: 51.1628% (minimum 65%, Missing); urinary bladder: 59.4595% (minimum 70%, Missing)",-0.138372,-0.211111,-0.31,0,80,unavailable,2.8,2.3,2.1,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134490,TMEM241,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.3810% (minimum 65%, Missing); basal ganglia: 68.7500% (minimum 75%, Missing); bone marrow: 66.6667% (minimum 75%, Missing); cerebral cortex: 45.8333% (minimum 75%, Missing); colon: 57.8947% (minimum 70%, Missing); duodenum: 59.4595% (minimum 75%, Missing); esophagus: 57.8947% (minimum 70%, Missing); heart muscle: 59.4595% (minimum 75%, Missing); kidney: 68.7500% (minimum 75%, Missing); liver: 57.8947% (minimum 75%, Missing); lung: 61.1111% (minimum 75%, Missing); lymph node: 61.1111% (minimum 70%, Missing); pancreas: 64.7059% (minimum 75%, Missing); parathyroid gland: 48.8889% (minimum 70%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); rectum: 50.0000% (minimum 70%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 68.7500% (minimum 75%, Missing); small intestine: 66.6667% (minimum 75%, Missing); smooth muscle: 44.0000% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); stomach: 61.1111% (minimum 70%, Missing); thyroid gland: 51.1628% (minimum 65%, Missing); urinary bladder: 59.4595% (minimum 70%, Missing)",-0.138372,-0.211111,-0.31,0,80,unavailable,2.8,2.3,2.1,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134490,TMEM241,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.3810% (minimum 65%, Baseline (adaptation disabled)); basal ganglia: 68.7500% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 45.8333% (minimum 75%, Baseline (adaptation disabled)); colon: 57.8947% (minimum 70%, Baseline (adaptation disabled)); duodenum: 59.4595% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.8947% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.4595% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.7500% (minimum 75%, Baseline (adaptation disabled)); liver: 57.8947% (minimum 75%, Baseline (adaptation disabled)); lung: 61.1111% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.1111% (minimum 70%, Baseline (adaptation disabled)); pancreas: 64.7059% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 48.8889% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 68.7500% (minimum 75%, Baseline (adaptation disabled)); rectum: 50.0000% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 68.7500% (minimum 75%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 44.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.1111% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.1111% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 51.1628% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 59.4595% (minimum 70%, Baseline (adaptation disabled))",-0.138372,-0.211111,-0.31,0,80,unavailable,2.8,2.3,2.1,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134490,TMEM241,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 80.0000% (minimum 90%, Approved)",-0.1,0.03,0.01,0,3,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134588,USP26,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.2,0.3,0.25,0,3,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134588,USP26,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.2,0.3,0.25,0,3,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134588,USP26,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.2,0.3,0.25,0,3,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134588,USP26,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.15,0.3,0.25,0,3,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134588,USP26,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8889% (minimum 99%, Missing); amygdala: 84.7619% (minimum 99%, Missing); basal ganglia: 83.1776% (minimum 99%, Missing); cerebellum: 96.7391% (minimum 99%, Missing); cerebral cortex: 85.5769% (minimum 99%, Missing); hippocampal formation: 87.2549% (minimum 99%, Missing); hypothalamus: 74.1667% (minimum 99%, Missing); midbrain: 87.2549% (minimum 99%, Missing); pituitary gland: 83.1776% (minimum 99%, Missing); retina: 97.8022% (minimum 99%, Missing); skeletal muscle: 97.8022% (minimum 99%, Missing); spinal cord: 89.0000% (minimum 99%, Missing)",0.0388889,0.03,-0.248333,0,80,unavailable,3.1,0,0.1,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134595,SOX3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 74.1667% (minimum 75%, Missing)",0.338889,0.3,-0.00833333,0,80,unavailable,3.1,0,0.1,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134595,SOX3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 74.1667% (minimum 75%, Missing)",0.338889,0.3,-0.00833333,0,80,unavailable,3.1,0,0.1,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134595,SOX3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 74.1667% (minimum 75%, Missing)",0.338889,0.3,-0.00833333,0,80,unavailable,3.1,0,0.1,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134595,SOX3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 74.1667% (minimum 75%, Baseline (adaptation disabled))",0.338889,0.3,-0.00833333,0,80,unavailable,3.1,0,0.1,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134595,SOX3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 76.9231% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 99%, Missing)",0.05,0.03,-0.220769,0,3,partial,0.3,0,0,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); skin 1 / fibroblasts: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134640,MTNR1B,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.0192308,0,3,partial,0.3,0,0,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); skin 1 / fibroblasts: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134640,MTNR1B,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.0192308,0,3,partial,0.3,0,0,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); skin 1 / fibroblasts: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134640,MTNR1B,grid_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.0192308,0,3,partial,0.3,0,0,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); skin 1 / fibroblasts: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134640,MTNR1B,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.0192308,0,3,partial,0.3,0,0,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); skin 1 / fibroblasts: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134640,MTNR1B,current_fixed,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.6332% (minimum 99%, Missing); amygdala: 97.3333% (minimum 99%, Missing); basal ganglia: 96.0526% (minimum 99%, Missing); bone marrow: 39.8182% (minimum 99%, Missing); cerebellum: 97.7679% (minimum 99%, Missing); cerebral cortex: 96.4758% (minimum 99%, Missing); choroid plexus: 98.2063% (minimum 99%, Missing); colon: 70.6452% (minimum 97%, Missing); duodenum: 73.0000% (minimum 99%, Missing); esophagus: 70.8738% (minimum 97%, Missing); hippocampal formation: 97.3333% (minimum 99%, Missing); hypothalamus: 97.3333% (minimum 99%, Missing); kidney: 96.4758% (minimum 99%, Missing); liver: 94.3966% (minimum 99%, Missing); lung: 93.9914% (minimum 95%, Enhanced); lymph node: 53.5452% (minimum 97%, Missing); midbrain: 96.9027% (minimum 99%, Missing); pancreas: 96.4758% (minimum 99%, Missing); pituitary gland: 97.3333% (minimum 99%, Missing); rectum: 66.7683% (minimum 97%, Missing); retina: 92.4051% (minimum 99%, Missing); skin: 77.9359% (minimum 95%, Missing); small intestine: 75.5172% (minimum 99%, Missing); smooth muscle: 89.0244% (minimum 95%, Enhanced); spinal cord: 96.4758% (minimum 99%, Missing); stomach: 82.3308% (minimum 97%, Missing); thymus: 36.6834% (minimum 95%, Missing); urinary bladder: 92.0168% (minimum 97%, Missing)",-0.583166,-0.434548,-0.591818,0,12,partial,33.1,19,37.8,"thymus: 37.8 nTPM (manageable, limit 5); bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 2); rectum: 10.9 nTPM (protected, limit 2); colon: 9.1 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),90,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134690,CDCA8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 39.8182% (minimum 75%, Missing); duodenum: 73.0000% (minimum 75%, Missing); lymph node: 53.5452% (minimum 70%, Missing); rectum: 66.7683% (minimum 70%, Missing); thymus: 36.6834% (minimum 65%, Missing)",-0.283166,-0.164548,-0.351818,0,12,partial,33.1,19,37.8,"thymus: 37.8 nTPM (manageable, limit 5); bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 2); rectum: 10.9 nTPM (protected, limit 2); colon: 9.1 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),90,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134690,CDCA8,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 39.8182% (minimum 75%, Missing); duodenum: 73.0000% (minimum 75%, Missing); lymph node: 53.5452% (minimum 70%, Missing); rectum: 66.7683% (minimum 70%, Missing); thymus: 36.6834% (minimum 65%, Missing)",-0.283166,-0.164548,-0.351818,0,12,partial,33.1,19,37.8,"thymus: 37.8 nTPM (manageable, limit 5); bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 3); rectum: 10.9 nTPM (protected, limit 3); colon: 9.1 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 3); retina: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),90,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134690,CDCA8,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 39.8182% (minimum 75%, Missing); duodenum: 73.0000% (minimum 75%, Missing); lymph node: 53.5452% (minimum 70%, Missing); rectum: 66.7683% (minimum 70%, Missing); thymus: 36.6834% (minimum 65%, Missing)",-0.283166,-0.164548,-0.351818,0,12,partial,33.1,19,37.8,"thymus: 37.8 nTPM (manageable, limit 5); bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 3); rectum: 10.9 nTPM (protected, limit 3); colon: 9.1 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 3); retina: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),90,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134690,CDCA8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 39.8182% (minimum 75%, Baseline (adaptation disabled)); duodenum: 73.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.5452% (minimum 70%, Baseline (adaptation disabled)); rectum: 66.7683% (minimum 70%, Baseline (adaptation disabled)); thymus: 36.6834% (minimum 65%, Baseline (adaptation disabled))",-0.283166,-0.164548,-0.351818,0,12,partial,33.1,19,37.8,"thymus: 37.8 nTPM (manageable, limit 5); bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 3); rectum: 10.9 nTPM (protected, limit 3); colon: 9.1 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),90,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134690,CDCA8,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.7833% (minimum 95%, Missing); adrenal gland: 94.2323% (minimum 99%, Missing); amygdala: 94.3857% (minimum 99%, Missing); basal ganglia: 94.9264% (minimum 99%, Missing); bone marrow: 55.0285% (minimum 99%, Missing); cerebellum: 93.2476% (minimum 99%, Missing); cerebral cortex: 92.2099% (minimum 99%, Missing); choroid plexus: 96.5058% (minimum 99%, Missing); colon: 83.6337% (minimum 97%, Missing); duodenum: 87.7458% (minimum 99%, Missing); esophagus: 88.9571% (minimum 97%, Missing); heart muscle: 95.3164% (minimum 99%, Missing); hippocampal formation: 94.0795% (minimum 99%, Missing); hypothalamus: 94.3089% (minimum 99%, Missing); kidney: 92.5778% (minimum 99%, Missing); liver: 84.6715% (minimum 99%, Missing); lung: 89.9922% (minimum 99%, Missing); lymph node: 83.0946% (minimum 97%, Missing); midbrain: 93.7753% (minimum 99%, Missing); pancreas: 88.0121% (minimum 99%, Missing); parathyroid gland: 91.4826% (minimum 97%, Missing); pituitary gland: 94.0795% (minimum 99%, Missing); rectum: 85.5457% (minimum 97%, Missing); retina: 93.0233% (minimum 99%, Missing); salivary gland: 92.3567% (minimum 97%, Missing); skeletal muscle: 94.5395% (minimum 99%, Missing); skin: 93.0979% (minimum 95%, Missing); small intestine: 87.3494% (minimum 99%, Missing); smooth muscle: 91.1233% (minimum 99%, Missing); spinal cord: 91.6996% (minimum 99%, Missing); spleen: 84.6715% (minimum 95%, Missing); stomach: 89.3683% (minimum 97%, Missing); thymus: 80.4997% (minimum 95%, Missing); thyroid gland: 90.9804% (minimum 95%, Missing); tongue: 94.6166% (minimum 97%, Missing); urinary bladder: 90.0621% (minimum 97%, Missing)",-0.145003,-0.139054,-0.439715,0,80,unavailable,94.8,23.6,28.1,"bone marrow: 94.8 nTPM (vital, limit 1); thymus: 28.1 nTPM (manageable, limit 5); lymph node: 23.6 nTPM (protected, limit 2); colon: 22.7 nTPM (protected, limit 2); liver: 21 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); rectum: 19.6 nTPM (protected, limit 2); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 2); stomach: 13.8 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 2); thyroid gland: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); skin: 8.6 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 2); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134758,RNF138,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.0285% (minimum 75%, Missing)",0.154997,0.130946,-0.199715,0,80,unavailable,94.8,23.6,28.1,"bone marrow: 94.8 nTPM (vital, limit 1); thymus: 28.1 nTPM (manageable, limit 5); lymph node: 23.6 nTPM (protected, limit 2); colon: 22.7 nTPM (protected, limit 2); liver: 21 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); rectum: 19.6 nTPM (protected, limit 2); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 2); stomach: 13.8 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 2); thyroid gland: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); skin: 8.6 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 2); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134758,RNF138,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.0285% (minimum 75%, Missing)",0.154997,0.130946,-0.199715,0,80,unavailable,94.8,23.6,28.1,"bone marrow: 94.8 nTPM (vital, limit 1); thymus: 28.1 nTPM (manageable, limit 5); lymph node: 23.6 nTPM (protected, limit 3); colon: 22.7 nTPM (protected, limit 3); liver: 21 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); rectum: 19.6 nTPM (protected, limit 3); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 3); stomach: 13.8 nTPM (protected, limit 3); adipose tissue: 13.2 nTPM (manageable, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 3); thyroid gland: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 3); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); skin: 8.6 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 3); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134758,RNF138,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.0285% (minimum 75%, Missing)",0.154997,0.130946,-0.199715,0,80,unavailable,94.8,23.6,28.1,"bone marrow: 94.8 nTPM (vital, limit 1); thymus: 28.1 nTPM (manageable, limit 5); lymph node: 23.6 nTPM (protected, limit 3); colon: 22.7 nTPM (protected, limit 3); liver: 21 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); rectum: 19.6 nTPM (protected, limit 3); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 3); stomach: 13.8 nTPM (protected, limit 3); adipose tissue: 13.2 nTPM (manageable, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 3); thyroid gland: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 3); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); skin: 8.6 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 3); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134758,RNF138,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.0285% (minimum 75%, Baseline (adaptation disabled))",0.154997,0.130946,-0.199715,0,80,unavailable,94.8,23.6,28.1,"bone marrow: 94.8 nTPM (vital, limit 1); thymus: 28.1 nTPM (manageable, limit 5); lymph node: 23.6 nTPM (protected, limit 3); colon: 22.7 nTPM (protected, limit 3); liver: 21 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); rectum: 19.6 nTPM (protected, limit 3); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 3); stomach: 13.8 nTPM (protected, limit 3); adipose tissue: 13.2 nTPM (manageable, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 3); thyroid gland: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 3); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); skin: 8.6 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 3); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134758,RNF138,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8666% (minimum 99%, Missing); basal ganglia: 97.9275% (minimum 99%, Missing); hippocampal formation: 98.9529% (minimum 99%, Missing); hypothalamus: 98.9529% (minimum 99%, Missing)",0.05,0.03,-0.0107254,0,3,partial,2.4,0.4,0.1,"basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134940,ACRV1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.229275,0,3,partial,2.4,0.4,0.1,"basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134940,ACRV1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.229275,0,3,partial,2.4,0.4,0.1,"basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134940,ACRV1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.229275,0,3,partial,2.4,0.4,0.1,"basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134940,ACRV1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349119,0.296485,0.229275,0,3,partial,2.4,0.4,0.1,"basal ganglia: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134940,ACRV1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.9599% (minimum 95%, Missing); adrenal gland: 63.1919% (minimum 99%, Missing); amygdala: 77.4887% (minimum 99%, Missing); basal ganglia: 76.5363% (minimum 99%, Missing); bone marrow: 68.5686% (minimum 99%, Missing); cerebellum: 86.2720% (minimum 99%, Missing); cerebral cortex: 68.4316% (minimum 99%, Missing); choroid plexus: 85.4115% (minimum 99%, Missing); colon: 62.7289% (minimum 97%, Missing); duodenum: 65.6130% (minimum 99%, Missing); esophagus: 68.5686% (minimum 97%, Missing); heart muscle: 61.9910% (minimum 99%, Missing); hippocampal formation: 75.6906% (minimum 99%, Missing); hypothalamus: 76.7077% (minimum 99%, Missing); kidney: 56.7053% (minimum 99%, Missing); liver: 46.7896% (minimum 99%, Missing); lung: 69.8267% (minimum 99%, Missing); lymph node: 74.9453% (minimum 97%, Missing); midbrain: 75.3575% (minimum 99%, Missing); pancreas: 66.6991% (minimum 99%, Missing); parathyroid gland: 56.9410% (minimum 97%, Missing); pituitary gland: 71.5778% (minimum 99%, Missing); rectum: 62.6143% (minimum 97%, Missing); retina: 78.6452% (minimum 99%, Missing); salivary gland: 61.8790% (minimum 97%, Missing); skeletal muscle: 76.3657% (minimum 99%, Missing); skin: 78.8262% (minimum 95%, Missing); small intestine: 64.7448% (minimum 99%, Missing); smooth muscle: 61.2154% (minimum 97%, Supported); spinal cord: 66.3760% (minimum 99%, Missing); spleen: 73.0277% (minimum 95%, Missing); stomach: 62.9017% (minimum 97%, Missing); thymus: 78.2857% (minimum 95%, Missing); thyroid gland: 46.9500% (minimum 95%, Missing); tongue: 74.2145% (minimum 97%, Missing); urinary bladder: 65.3626% (minimum 97%, Missing)",-0.4805,-0.40059,-0.522104,0,4,partial,77.9,51.8,77.4,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (manageable, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 2); smooth muscle: 43.4 nTPM (vital, limit 3); salivary gland: 42.2 nTPM (protected, limit 2); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 2); colon: 40.7 nTPM (protected, limit 2); stomach: 40.4 nTPM (protected, limit 2); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 2); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (manageable, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 2); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); pituitary gland: 27.2 nTPM (vital, limit 1); spleen: 25.3 nTPM (manageable, limit 5); tongue: 23.8 nTPM (protected, limit 2); lymph node: 22.9 nTPM (protected, limit 2); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); thymus: 19 nTPM (manageable, limit 5); retina: 18.6 nTPM (vital, limit 1); skin: 18.4 nTPM (manageable, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 1 / vascular mural cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134970,TMED7,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.1919% (minimum 75%, Missing); bone marrow: 68.5686% (minimum 75%, Missing); cerebral cortex: 68.4316% (minimum 75%, Missing); colon: 62.7289% (minimum 70%, Missing); duodenum: 65.6130% (minimum 75%, Missing); esophagus: 68.5686% (minimum 70%, Missing); heart muscle: 61.9910% (minimum 75%, Missing); kidney: 56.7053% (minimum 75%, Missing); liver: 46.7896% (minimum 75%, Missing); lung: 69.8267% (minimum 75%, Missing); pancreas: 66.6991% (minimum 75%, Missing); parathyroid gland: 56.9410% (minimum 70%, Missing); pituitary gland: 71.5778% (minimum 75%, Missing); rectum: 62.6143% (minimum 70%, Missing); salivary gland: 61.8790% (minimum 70%, Missing); small intestine: 64.7448% (minimum 75%, Missing); smooth muscle: 61.2154% (minimum 65%, Supported); spinal cord: 66.3760% (minimum 75%, Missing); stomach: 62.9017% (minimum 70%, Missing); thyroid gland: 46.9500% (minimum 65%, Missing); urinary bladder: 65.3626% (minimum 70%, Missing)",-0.1805,-0.13059,-0.282104,0,4,partial,77.9,51.8,77.4,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (manageable, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 2); smooth muscle: 43.4 nTPM (vital, limit 3); salivary gland: 42.2 nTPM (protected, limit 2); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 2); colon: 40.7 nTPM (protected, limit 2); stomach: 40.4 nTPM (protected, limit 2); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 2); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (manageable, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 2); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); pituitary gland: 27.2 nTPM (vital, limit 1); spleen: 25.3 nTPM (manageable, limit 5); tongue: 23.8 nTPM (protected, limit 2); lymph node: 22.9 nTPM (protected, limit 2); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); thymus: 19 nTPM (manageable, limit 5); retina: 18.6 nTPM (vital, limit 1); skin: 18.4 nTPM (manageable, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 1 / vascular mural cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134970,TMED7,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.1919% (minimum 75%, Missing); bone marrow: 68.5686% (minimum 75%, Missing); cerebral cortex: 68.4316% (minimum 75%, Missing); colon: 62.7289% (minimum 70%, Missing); duodenum: 65.6130% (minimum 75%, Missing); esophagus: 68.5686% (minimum 70%, Missing); heart muscle: 61.9910% (minimum 75%, Missing); kidney: 56.7053% (minimum 75%, Missing); liver: 46.7896% (minimum 75%, Missing); lung: 69.8267% (minimum 75%, Missing); pancreas: 66.6991% (minimum 75%, Missing); parathyroid gland: 56.9410% (minimum 70%, Missing); pituitary gland: 71.5778% (minimum 75%, Missing); rectum: 62.6143% (minimum 70%, Missing); salivary gland: 61.8790% (minimum 70%, Missing); small intestine: 64.7448% (minimum 75%, Missing); smooth muscle: 61.2154% (minimum 65%, Supported); spinal cord: 66.3760% (minimum 75%, Missing); stomach: 62.9017% (minimum 70%, Missing); thyroid gland: 46.9500% (minimum 65%, Missing); urinary bladder: 65.3626% (minimum 70%, Missing)",-0.1805,-0.13059,-0.282104,0,4,partial,77.9,51.8,77.4,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (manageable, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 3); smooth muscle: 43.4 nTPM (vital, limit 3); salivary gland: 42.2 nTPM (protected, limit 3); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 3); colon: 40.7 nTPM (protected, limit 3); stomach: 40.4 nTPM (protected, limit 3); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 3); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (manageable, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 3); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); pituitary gland: 27.2 nTPM (vital, limit 1); spleen: 25.3 nTPM (manageable, limit 5); tongue: 23.8 nTPM (protected, limit 3); lymph node: 22.9 nTPM (protected, limit 3); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); thymus: 19 nTPM (manageable, limit 5); retina: 18.6 nTPM (vital, limit 1); skin: 18.4 nTPM (manageable, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 1 / vascular mural cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134970,TMED7,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.1919% (minimum 75%, Missing); bone marrow: 68.5686% (minimum 75%, Missing); cerebral cortex: 68.4316% (minimum 75%, Missing); colon: 62.7289% (minimum 70%, Missing); duodenum: 65.6130% (minimum 75%, Missing); esophagus: 68.5686% (minimum 70%, Missing); heart muscle: 61.9910% (minimum 75%, Missing); kidney: 56.7053% (minimum 75%, Missing); liver: 46.7896% (minimum 75%, Missing); lung: 69.8267% (minimum 75%, Missing); pancreas: 66.6991% (minimum 75%, Missing); parathyroid gland: 56.9410% (minimum 70%, Missing); pituitary gland: 71.5778% (minimum 75%, Missing); rectum: 62.6143% (minimum 70%, Missing); salivary gland: 61.8790% (minimum 70%, Missing); small intestine: 64.7448% (minimum 75%, Missing); smooth muscle: 61.2154% (minimum 65%, Supported); spinal cord: 66.3760% (minimum 75%, Missing); stomach: 62.9017% (minimum 70%, Missing); thyroid gland: 46.9500% (minimum 65%, Missing); urinary bladder: 65.3626% (minimum 70%, Missing)",-0.1805,-0.13059,-0.282104,0,4,partial,77.9,51.8,77.4,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (manageable, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 3); smooth muscle: 43.4 nTPM (vital, limit 3); salivary gland: 42.2 nTPM (protected, limit 3); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 3); colon: 40.7 nTPM (protected, limit 3); stomach: 40.4 nTPM (protected, limit 3); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 3); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (manageable, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 3); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); pituitary gland: 27.2 nTPM (vital, limit 1); spleen: 25.3 nTPM (manageable, limit 5); tongue: 23.8 nTPM (protected, limit 3); lymph node: 22.9 nTPM (protected, limit 3); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); thymus: 19 nTPM (manageable, limit 5); retina: 18.6 nTPM (vital, limit 1); skin: 18.4 nTPM (manageable, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 1 / vascular mural cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134970,TMED7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.1919% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 68.5686% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.4316% (minimum 75%, Baseline (adaptation disabled)); colon: 62.7289% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.6130% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.5686% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 61.9910% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.7053% (minimum 75%, Baseline (adaptation disabled)); liver: 46.7896% (minimum 75%, Baseline (adaptation disabled)); lung: 69.8267% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.6991% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 56.9410% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.5778% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.6143% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 61.8790% (minimum 70%, Baseline (adaptation disabled)); small intestine: 64.7448% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.2154% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.3760% (minimum 75%, Baseline (adaptation disabled)); stomach: 62.9017% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 46.9500% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 65.3626% (minimum 70%, Baseline (adaptation disabled))",-0.1805,-0.13059,-0.282104,0,4,partial,77.9,51.8,77.4,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (manageable, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 3); smooth muscle: 43.4 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 3); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 3); colon: 40.7 nTPM (protected, limit 3); stomach: 40.4 nTPM (protected, limit 3); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 3); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (manageable, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 3); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); pituitary gland: 27.2 nTPM (vital, limit 1); spleen: 25.3 nTPM (manageable, limit 5); tongue: 23.8 nTPM (protected, limit 3); lymph node: 22.9 nTPM (protected, limit 3); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); thymus: 19 nTPM (manageable, limit 5); retina: 18.6 nTPM (vital, limit 1); skin: 18.4 nTPM (manageable, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 1 / vascular mural cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000134970,TMED7,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 78.2609% (minimum 99%, Missing); amygdala: 35.6436% (minimum 99%, Missing); basal ganglia: 31.0345% (minimum 99%, Missing); bone marrow: 78.2609% (minimum 95%, Enhanced); cerebellum: 27.4809% (minimum 99%, Missing); cerebral cortex: 24.8276% (minimum 99%, Missing); choroid plexus: 42.3529% (minimum 99%, Missing); duodenum: 87.8049% (minimum 95%, Enhanced); heart muscle: 90.0000% (minimum 95%, Enhanced); hippocampal formation: 31.5789% (minimum 99%, Missing); hypothalamus: 29.7521% (minimum 99%, Missing); kidney: 83.7209% (minimum 95%, Enhanced); lung: 92.3077% (minimum 95%, Enhanced); lymph node: 78.2609% (minimum 97%, Missing); midbrain: 34.9515% (minimum 99%, Missing); pancreas: 94.7368% (minimum 95%, Enhanced); pituitary gland: 41.8605% (minimum 99%, Missing); retina: 42.8571% (minimum 99%, Missing); skeletal muscle: 85.7143% (minimum 95%, Enhanced); small intestine: 87.8049% (minimum 95%, Enhanced); smooth muscle: 94.7368% (minimum 95%, Enhanced); spinal cord: 42.3529% (minimum 99%, Missing); thymus: 73.4694% (minimum 95%, Missing); thyroid gland: 87.8049% (minimum 95%, Missing)",-0.215306,-0.187391,-0.741724,0,0,routine_complete,10.9,1,1.3,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135119,RNFT2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 35.6436% (minimum 75%, Missing); basal ganglia: 31.0345% (minimum 75%, Missing); cerebellum: 27.4809% (minimum 75%, Missing); cerebral cortex: 24.8276% (minimum 75%, Missing); choroid plexus: 42.3529% (minimum 75%, Missing); hippocampal formation: 31.5789% (minimum 75%, Missing); hypothalamus: 29.7521% (minimum 75%, Missing); midbrain: 34.9515% (minimum 75%, Missing); pituitary gland: 41.8605% (minimum 75%, Missing); retina: 42.8571% (minimum 75%, Missing); spinal cord: 42.3529% (minimum 75%, Missing)",0.0846939,0.0826087,-0.501724,0,0,routine_complete,10.9,1,1.3,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135119,RNFT2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 35.6436% (minimum 75%, Missing); basal ganglia: 31.0345% (minimum 75%, Missing); cerebellum: 27.4809% (minimum 75%, Missing); cerebral cortex: 24.8276% (minimum 75%, Missing); choroid plexus: 42.3529% (minimum 75%, Missing); hippocampal formation: 31.5789% (minimum 75%, Missing); hypothalamus: 29.7521% (minimum 75%, Missing); midbrain: 34.9515% (minimum 75%, Missing); pituitary gland: 41.8605% (minimum 75%, Missing); retina: 42.8571% (minimum 75%, Missing); spinal cord: 42.3529% (minimum 75%, Missing)",0.0846939,0.0826087,-0.501724,0,0,routine_complete,10.9,1,1.3,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135119,RNFT2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 35.6436% (minimum 75%, Missing); basal ganglia: 31.0345% (minimum 75%, Missing); cerebellum: 27.4809% (minimum 75%, Missing); cerebral cortex: 24.8276% (minimum 75%, Missing); choroid plexus: 42.3529% (minimum 75%, Missing); hippocampal formation: 31.5789% (minimum 75%, Missing); hypothalamus: 29.7521% (minimum 75%, Missing); midbrain: 34.9515% (minimum 75%, Missing); pituitary gland: 41.8605% (minimum 75%, Missing); retina: 42.8571% (minimum 75%, Missing); spinal cord: 42.3529% (minimum 75%, Missing)",0.0846939,0.0826087,-0.501724,0,0,routine_complete,10.9,1,1.3,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135119,RNFT2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 35.6436% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 31.0345% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 27.4809% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 24.8276% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 42.3529% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 31.5789% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 29.7521% (minimum 75%, Baseline (adaptation disabled)); midbrain: 34.9515% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 41.8605% (minimum 75%, Baseline (adaptation disabled)); retina: 42.8571% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 42.3529% (minimum 75%, Baseline (adaptation disabled))",0.0846939,0.0826087,-0.501724,0,0,routine_complete,10.9,1,1.3,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135119,RNFT2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135175,OCM2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135175,OCM2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135175,OCM2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135175,OCM2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135175,OCM2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0404543,0.03,0.01,0,0,routine_complete,0.1,3.1,5.4,"thymus: 5.4 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135222,CSN2,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340454,0.3,0.25,0,0,routine_complete,0.1,3.1,5.4,"thymus: 5.4 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135222,CSN2,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340454,0.3,0.25,0,0,routine_complete,0.1,3.1,5.4,"thymus: 5.4 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135222,CSN2,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340454,0.3,0.25,0,0,routine_complete,0.1,3.1,5.4,"thymus: 5.4 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135222,CSN2,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340454,0.294498,0.249822,0,0,routine_complete,0.1,3.1,5.4,"thymus: 5.4 nTPM (manageable, limit 5); salivary gland: 3.1 nTPM (protected, limit 3)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135222,CSN2,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 98.9166% (minimum 99%, Missing); retina: 98.9166% (minimum 99%, Missing)",0.0489059,0.0289059,-0.000834236,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135248,GARIN1B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348906,0.298906,0.239166,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135248,GARIN1B,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348906,0.298906,0.239166,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135248,GARIN1B,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348906,0.298906,0.239166,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135248,GARIN1B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348906,0.298906,0.239166,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135248,GARIN1B,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.0968% (minimum 95%, Missing); adrenal gland: 89.0110% (minimum 99%, Missing); amygdala: 42.4084% (minimum 99%, Missing); basal ganglia: 36.3229% (minimum 99%, Missing); bone marrow: 97.5904% (minimum 99%, Missing); cerebellum: 46.8208% (minimum 99%, Missing); cerebral cortex: 37.1560% (minimum 99%, Missing); choroid plexus: 66.9421% (minimum 99%, Missing); colon: 84.3750% (minimum 97%, Missing); duodenum: 98.7805% (minimum 99%, Missing); esophagus: 90.0000% (minimum 97%, Missing); heart muscle: 68.6441% (minimum 99%, Missing); hippocampal formation: 46.8208% (minimum 99%, Missing); hypothalamus: 46.2857% (minimum 99%, Missing); kidney: 89.0110% (minimum 99%, Missing); liver: 98.7805% (minimum 99%, Missing); lung: 91.0112% (minimum 99%, Missing); lymph node: 86.1702% (minimum 97%, Missing); midbrain: 45.0000% (minimum 99%, Missing); pancreas: 75.7009% (minimum 99%, Missing); parathyroid gland: 79.4118% (minimum 97%, Missing); pituitary gland: 52.5974% (minimum 99%, Missing); rectum: 95.2941% (minimum 97%, Missing); retina: 69.2308% (minimum 99%, Missing); salivary gland: 93.1034% (minimum 97%, Missing); skeletal muscle: 88.0435% (minimum 99%, Missing); small intestine: 91.0112% (minimum 99%, Missing); smooth muscle: 90.0000% (minimum 99%, Missing); spinal cord: 53.2895% (minimum 99%, Missing); spleen: 92.0455% (minimum 95%, Missing); stomach: 84.3750% (minimum 97%, Missing); thymus: 79.4118% (minimum 95%, Missing); thyroid gland: 77.8846% (minimum 95%, Missing); tongue: 86.1702% (minimum 97%, Missing); urinary bladder: 86.1702% (minimum 97%, Missing)",-0.171154,-0.175882,-0.626771,0,80,unavailable,14.2,2.1,2.3,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135314,KHDC1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 42.4084% (minimum 75%, Missing); basal ganglia: 36.3229% (minimum 75%, Missing); cerebellum: 46.8208% (minimum 75%, Missing); cerebral cortex: 37.1560% (minimum 75%, Missing); choroid plexus: 66.9421% (minimum 75%, Missing); heart muscle: 68.6441% (minimum 75%, Missing); hippocampal formation: 46.8208% (minimum 75%, Missing); hypothalamus: 46.2857% (minimum 75%, Missing); midbrain: 45.0000% (minimum 75%, Missing); pituitary gland: 52.5974% (minimum 75%, Missing); retina: 69.2308% (minimum 75%, Missing); spinal cord: 53.2895% (minimum 75%, Missing)",0.128846,0.0941176,-0.386771,0,80,unavailable,14.2,2.1,2.3,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135314,KHDC1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 42.4084% (minimum 75%, Missing); basal ganglia: 36.3229% (minimum 75%, Missing); cerebellum: 46.8208% (minimum 75%, Missing); cerebral cortex: 37.1560% (minimum 75%, Missing); choroid plexus: 66.9421% (minimum 75%, Missing); heart muscle: 68.6441% (minimum 75%, Missing); hippocampal formation: 46.8208% (minimum 75%, Missing); hypothalamus: 46.2857% (minimum 75%, Missing); midbrain: 45.0000% (minimum 75%, Missing); pituitary gland: 52.5974% (minimum 75%, Missing); retina: 69.2308% (minimum 75%, Missing); spinal cord: 53.2895% (minimum 75%, Missing)",0.128846,0.0941176,-0.386771,0,80,unavailable,14.2,2.1,2.3,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135314,KHDC1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 42.4084% (minimum 75%, Missing); basal ganglia: 36.3229% (minimum 75%, Missing); cerebellum: 46.8208% (minimum 75%, Missing); cerebral cortex: 37.1560% (minimum 75%, Missing); choroid plexus: 66.9421% (minimum 75%, Missing); heart muscle: 68.6441% (minimum 75%, Missing); hippocampal formation: 46.8208% (minimum 75%, Missing); hypothalamus: 46.2857% (minimum 75%, Missing); midbrain: 45.0000% (minimum 75%, Missing); pituitary gland: 52.5974% (minimum 75%, Missing); retina: 69.2308% (minimum 75%, Missing); spinal cord: 53.2895% (minimum 75%, Missing)",0.128846,0.0941176,-0.386771,0,80,unavailable,14.2,2.1,2.3,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135314,KHDC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 42.4084% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 36.3229% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 46.8208% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 37.1560% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.9421% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 68.6441% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 46.8208% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 46.2857% (minimum 75%, Baseline (adaptation disabled)); midbrain: 45.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 52.5974% (minimum 75%, Baseline (adaptation disabled)); retina: 69.2308% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.2895% (minimum 75%, Baseline (adaptation disabled))",0.128846,0.0941176,-0.386771,0,80,unavailable,14.2,2.1,2.3,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135314,KHDC1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.1125% (minimum 95%, Missing); adrenal gland: 41.1475% (minimum 99%, Missing); amygdala: 42.5424% (minimum 99%, Missing); basal ganglia: 43.1271% (minimum 99%, Missing); bone marrow: 26.5048% (minimum 99%, Missing); cerebellum: 47.8095% (minimum 99%, Missing); cerebral cortex: 41.2151% (minimum 99%, Missing); choroid plexus: 50.7071% (minimum 99%, Missing); colon: 56.6591% (minimum 97%, Missing); duodenum: 66.9333% (minimum 99%, Missing); esophagus: 43.7282% (minimum 97%, Missing); heart muscle: 45.6364% (minimum 99%, Missing); hippocampal formation: 43.6522% (minimum 99%, Missing); hypothalamus: 44.7415% (minimum 99%, Missing); kidney: 55.4084% (minimum 99%, Missing); liver: 45.3069% (minimum 99%, Missing); lung: 43.8045% (minimum 99%, Missing); lymph node: 47.5379% (minimum 97%, Missing); midbrain: 46.0550% (minimum 99%, Missing); pancreas: 66.2269% (minimum 99%, Missing); parathyroid gland: 59.3381% (minimum 97%, Missing); pituitary gland: 52.4008% (minimum 99%, Missing); rectum: 67.4731% (minimum 97%, Missing); retina: 46.5677% (minimum 99%, Missing); salivary gland: 51.3292% (minimum 97%, Missing); skeletal muscle: 21.0747% (minimum 99%, Missing); skin: 53.0655% (minimum 95%, Missing); small intestine: 52.9536% (minimum 99%, Missing); smooth muscle: 61.3692% (minimum 99%, Missing); spinal cord: 44.5826% (minimum 99%, Missing); spleen: 34.3836% (minimum 95%, Missing); stomach: 60.6280% (minimum 97%, Missing); thymus: 45.2252% (minimum 95%, Missing); thyroid gland: 60.0478% (minimum 95%, Missing); tongue: 38.0303% (minimum 97%, Missing); urinary bladder: 52.7311% (minimum 97%, Missing)",-0.606164,-0.589697,-0.779253,0,80,unavailable,94,40.9,47.9,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); spleen: 47.9 nTPM (manageable, limit 5); tongue: 40.9 nTPM (protected, limit 2); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 2); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (manageable, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); thymus: 30.4 nTPM (manageable, limit 5); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 2); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); salivary gland: 23.8 nTPM (protected, limit 2); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 2); small intestine: 22.3 nTPM (vital, limit 1); skin: 22.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 2); parathyroid gland: 17.2 nTPM (protected, limit 2); thyroid gland: 16.7 nTPM (manageable, limit 5); stomach: 16.3 nTPM (protected, limit 2); smooth muscle: 15.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135334,AKIRIN2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.1125% (minimum 65%, Missing); adrenal gland: 41.1475% (minimum 75%, Missing); amygdala: 42.5424% (minimum 75%, Missing); basal ganglia: 43.1271% (minimum 75%, Missing); bone marrow: 26.5048% (minimum 75%, Missing); cerebellum: 47.8095% (minimum 75%, Missing); cerebral cortex: 41.2151% (minimum 75%, Missing); choroid plexus: 50.7071% (minimum 75%, Missing); colon: 56.6591% (minimum 70%, Missing); duodenum: 66.9333% (minimum 75%, Missing); esophagus: 43.7282% (minimum 70%, Missing); heart muscle: 45.6364% (minimum 75%, Missing); hippocampal formation: 43.6522% (minimum 75%, Missing); hypothalamus: 44.7415% (minimum 75%, Missing); kidney: 55.4084% (minimum 75%, Missing); liver: 45.3069% (minimum 75%, Missing); lung: 43.8045% (minimum 75%, Missing); lymph node: 47.5379% (minimum 70%, Missing); midbrain: 46.0550% (minimum 75%, Missing); pancreas: 66.2269% (minimum 75%, Missing); parathyroid gland: 59.3381% (minimum 70%, Missing); pituitary gland: 52.4008% (minimum 75%, Missing); rectum: 67.4731% (minimum 70%, Missing); retina: 46.5677% (minimum 75%, Missing); salivary gland: 51.3292% (minimum 70%, Missing); skeletal muscle: 21.0747% (minimum 75%, Missing); skin: 53.0655% (minimum 65%, Missing); small intestine: 52.9536% (minimum 75%, Missing); smooth muscle: 61.3692% (minimum 75%, Missing); spinal cord: 44.5826% (minimum 75%, Missing); spleen: 34.3836% (minimum 65%, Missing); stomach: 60.6280% (minimum 70%, Missing); thymus: 45.2252% (minimum 65%, Missing); thyroid gland: 60.0478% (minimum 65%, Missing); tongue: 38.0303% (minimum 70%, Missing); urinary bladder: 52.7311% (minimum 70%, Missing)",-0.306164,-0.319697,-0.539253,0,80,unavailable,94,40.9,47.9,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); spleen: 47.9 nTPM (manageable, limit 5); tongue: 40.9 nTPM (protected, limit 2); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 2); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (manageable, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); thymus: 30.4 nTPM (manageable, limit 5); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 2); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); salivary gland: 23.8 nTPM (protected, limit 2); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 2); small intestine: 22.3 nTPM (vital, limit 1); skin: 22.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 2); parathyroid gland: 17.2 nTPM (protected, limit 2); thyroid gland: 16.7 nTPM (manageable, limit 5); stomach: 16.3 nTPM (protected, limit 2); smooth muscle: 15.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135334,AKIRIN2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.1125% (minimum 65%, Missing); adrenal gland: 41.1475% (minimum 75%, Missing); amygdala: 42.5424% (minimum 75%, Missing); basal ganglia: 43.1271% (minimum 75%, Missing); bone marrow: 26.5048% (minimum 75%, Missing); cerebellum: 47.8095% (minimum 75%, Missing); cerebral cortex: 41.2151% (minimum 75%, Missing); choroid plexus: 50.7071% (minimum 75%, Missing); colon: 56.6591% (minimum 70%, Missing); duodenum: 66.9333% (minimum 75%, Missing); esophagus: 43.7282% (minimum 70%, Missing); heart muscle: 45.6364% (minimum 75%, Missing); hippocampal formation: 43.6522% (minimum 75%, Missing); hypothalamus: 44.7415% (minimum 75%, Missing); kidney: 55.4084% (minimum 75%, Missing); liver: 45.3069% (minimum 75%, Missing); lung: 43.8045% (minimum 75%, Missing); lymph node: 47.5379% (minimum 70%, Missing); midbrain: 46.0550% (minimum 75%, Missing); pancreas: 66.2269% (minimum 75%, Missing); parathyroid gland: 59.3381% (minimum 70%, Missing); pituitary gland: 52.4008% (minimum 75%, Missing); rectum: 67.4731% (minimum 70%, Missing); retina: 46.5677% (minimum 75%, Missing); salivary gland: 51.3292% (minimum 70%, Missing); skeletal muscle: 21.0747% (minimum 75%, Missing); skin: 53.0655% (minimum 65%, Missing); small intestine: 52.9536% (minimum 75%, Missing); smooth muscle: 61.3692% (minimum 75%, Missing); spinal cord: 44.5826% (minimum 75%, Missing); spleen: 34.3836% (minimum 65%, Missing); stomach: 60.6280% (minimum 70%, Missing); thymus: 45.2252% (minimum 65%, Missing); thyroid gland: 60.0478% (minimum 65%, Missing); tongue: 38.0303% (minimum 70%, Missing); urinary bladder: 52.7311% (minimum 70%, Missing)",-0.306164,-0.319697,-0.539253,0,80,unavailable,94,40.9,47.9,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); spleen: 47.9 nTPM (manageable, limit 5); tongue: 40.9 nTPM (protected, limit 3); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 3); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (manageable, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); thymus: 30.4 nTPM (manageable, limit 5); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 3); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); salivary gland: 23.8 nTPM (protected, limit 3); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 3); small intestine: 22.3 nTPM (vital, limit 1); skin: 22.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 3); parathyroid gland: 17.2 nTPM (protected, limit 3); thyroid gland: 16.7 nTPM (manageable, limit 5); stomach: 16.3 nTPM (protected, limit 3); smooth muscle: 15.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135334,AKIRIN2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.1125% (minimum 65%, Missing); adrenal gland: 41.1475% (minimum 75%, Missing); amygdala: 42.5424% (minimum 75%, Missing); basal ganglia: 43.1271% (minimum 75%, Missing); bone marrow: 26.5048% (minimum 75%, Missing); cerebellum: 47.8095% (minimum 75%, Missing); cerebral cortex: 41.2151% (minimum 75%, Missing); choroid plexus: 50.7071% (minimum 75%, Missing); colon: 56.6591% (minimum 70%, Missing); duodenum: 66.9333% (minimum 75%, Missing); esophagus: 43.7282% (minimum 70%, Missing); heart muscle: 45.6364% (minimum 75%, Missing); hippocampal formation: 43.6522% (minimum 75%, Missing); hypothalamus: 44.7415% (minimum 75%, Missing); kidney: 55.4084% (minimum 75%, Missing); liver: 45.3069% (minimum 75%, Missing); lung: 43.8045% (minimum 75%, Missing); lymph node: 47.5379% (minimum 70%, Missing); midbrain: 46.0550% (minimum 75%, Missing); pancreas: 66.2269% (minimum 75%, Missing); parathyroid gland: 59.3381% (minimum 70%, Missing); pituitary gland: 52.4008% (minimum 75%, Missing); rectum: 67.4731% (minimum 70%, Missing); retina: 46.5677% (minimum 75%, Missing); salivary gland: 51.3292% (minimum 70%, Missing); skeletal muscle: 21.0747% (minimum 75%, Missing); skin: 53.0655% (minimum 65%, Missing); small intestine: 52.9536% (minimum 75%, Missing); smooth muscle: 61.3692% (minimum 75%, Missing); spinal cord: 44.5826% (minimum 75%, Missing); spleen: 34.3836% (minimum 65%, Missing); stomach: 60.6280% (minimum 70%, Missing); thymus: 45.2252% (minimum 65%, Missing); thyroid gland: 60.0478% (minimum 65%, Missing); tongue: 38.0303% (minimum 70%, Missing); urinary bladder: 52.7311% (minimum 70%, Missing)",-0.306164,-0.319697,-0.539253,0,80,unavailable,94,40.9,47.9,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); spleen: 47.9 nTPM (manageable, limit 5); tongue: 40.9 nTPM (protected, limit 3); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 3); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (manageable, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); thymus: 30.4 nTPM (manageable, limit 5); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 3); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); salivary gland: 23.8 nTPM (protected, limit 3); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 3); small intestine: 22.3 nTPM (vital, limit 1); skin: 22.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 3); parathyroid gland: 17.2 nTPM (protected, limit 3); thyroid gland: 16.7 nTPM (manageable, limit 5); stomach: 16.3 nTPM (protected, limit 3); smooth muscle: 15.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135334,AKIRIN2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.1125% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 41.1475% (minimum 75%, Baseline (adaptation disabled)); amygdala: 42.5424% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 43.1271% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 26.5048% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 47.8095% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 41.2151% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 50.7071% (minimum 75%, Baseline (adaptation disabled)); colon: 56.6591% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.9333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 43.7282% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 45.6364% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 43.6522% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 44.7415% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.4084% (minimum 75%, Baseline (adaptation disabled)); liver: 45.3069% (minimum 75%, Baseline (adaptation disabled)); lung: 43.8045% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.5379% (minimum 70%, Baseline (adaptation disabled)); midbrain: 46.0550% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.2269% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.3381% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 52.4008% (minimum 75%, Baseline (adaptation disabled)); rectum: 67.4731% (minimum 70%, Baseline (adaptation disabled)); retina: 46.5677% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.3292% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 21.0747% (minimum 75%, Baseline (adaptation disabled)); skin: 53.0655% (minimum 65%, Baseline (adaptation disabled)); small intestine: 52.9536% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.3692% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 44.5826% (minimum 75%, Baseline (adaptation disabled)); spleen: 34.3836% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.6280% (minimum 70%, Baseline (adaptation disabled)); thymus: 45.2252% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 60.0478% (minimum 65%, Baseline (adaptation disabled)); tongue: 38.0303% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.7311% (minimum 70%, Baseline (adaptation disabled))",-0.306164,-0.319697,-0.539253,0,80,unavailable,94,40.9,47.9,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); spleen: 47.9 nTPM (manageable, limit 5); tongue: 40.9 nTPM (protected, limit 3); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 3); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (manageable, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); thymus: 30.4 nTPM (manageable, limit 5); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 3); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); salivary gland: 23.8 nTPM (protected, limit 3); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 3); small intestine: 22.3 nTPM (vital, limit 1); skin: 22.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 3); parathyroid gland: 17.2 nTPM (protected, limit 3); thyroid gland: 16.7 nTPM (manageable, limit 5); stomach: 16.3 nTPM (protected, limit 3); smooth muscle: 15.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135334,AKIRIN2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.6098% (minimum 80%, Supported); adrenal gland: 83.7838% (minimum 99%, Missing); amygdala: 68.3824% (minimum 99%, Missing); basal ganglia: 68.8889% (minimum 99%, Missing); bone marrow: 72.6562% (minimum 99%, Missing); cerebellum: 70.4545% (minimum 97%, Supported); cerebral cortex: 68.8889% (minimum 99%, Missing); choroid plexus: 40.0862% (minimum 99%, Missing); colon: 79.4872% (minimum 97%, Missing); duodenum: 90.2913% (minimum 99%, Missing); esophagus: 76.2295% (minimum 97%, Missing); heart muscle: 80.1724% (minimum 99%, Missing); hippocampal formation: 67.3913% (minimum 99%, Missing); hypothalamus: 69.9248% (minimum 99%, Missing); kidney: 77.5000% (minimum 99%, Missing); liver: 89.4231% (minimum 99%, Missing); lung: 70.4545% (minimum 99%, Missing); lymph node: 86.9159% (minimum 90%, Supported); midbrain: 69.9248% (minimum 99%, Missing); pancreas: 79.4872% (minimum 99%, Missing); parathyroid gland: 35.7692% (minimum 97%, Missing); pituitary gland: 72.6562% (minimum 99%, Missing); rectum: 86.1111% (minimum 97%, Missing); retina: 41.1504% (minimum 99%, Missing); salivary gland: 63.2653% (minimum 97%, Missing); skeletal muscle: 89.4231% (minimum 99%, Missing); small intestine: 87.7358% (minimum 99%, Missing); smooth muscle: 69.9248% (minimum 97%, Supported); spinal cord: 60.7843% (minimum 99%, Missing); stomach: 86.1111% (minimum 97%, Missing); thymus: 90.2913% (minimum 95%, Missing); thyroid gland: 60.3896% (minimum 95%, Missing); tongue: 83.0357% (minimum 97%, Missing); urinary bladder: 73.8095% (minimum 97%, Missing)",-0.346104,-0.612308,-0.589138,0,5,partial,13.9,16.7,6.1,"parathyroid gland: 16.7 nTPM (protected, limit 2); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); spinal cord: 6 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 3); lung: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135338,LCA5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 68.3824% (minimum 75%, Missing); basal ganglia: 68.8889% (minimum 75%, Missing); bone marrow: 72.6562% (minimum 75%, Missing); cerebral cortex: 68.8889% (minimum 75%, Missing); choroid plexus: 40.0862% (minimum 75%, Missing); hippocampal formation: 67.3913% (minimum 75%, Missing); hypothalamus: 69.9248% (minimum 75%, Missing); lung: 70.4545% (minimum 75%, Missing); midbrain: 69.9248% (minimum 75%, Missing); parathyroid gland: 35.7692% (minimum 70%, Missing); pituitary gland: 72.6562% (minimum 75%, Missing); retina: 41.1504% (minimum 75%, Missing); salivary gland: 63.2653% (minimum 70%, Missing); spinal cord: 60.7843% (minimum 75%, Missing); thyroid gland: 60.3896% (minimum 65%, Missing)",-0.0461039,-0.342308,-0.349138,0,5,partial,13.9,16.7,6.1,"parathyroid gland: 16.7 nTPM (protected, limit 2); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); spinal cord: 6 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 3); lung: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135338,LCA5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 68.3824% (minimum 75%, Missing); basal ganglia: 68.8889% (minimum 75%, Missing); bone marrow: 72.6562% (minimum 75%, Missing); cerebral cortex: 68.8889% (minimum 75%, Missing); choroid plexus: 40.0862% (minimum 75%, Missing); hippocampal formation: 67.3913% (minimum 75%, Missing); hypothalamus: 69.9248% (minimum 75%, Missing); lung: 70.4545% (minimum 75%, Missing); midbrain: 69.9248% (minimum 75%, Missing); parathyroid gland: 35.7692% (minimum 70%, Missing); pituitary gland: 72.6562% (minimum 75%, Missing); retina: 41.1504% (minimum 75%, Missing); salivary gland: 63.2653% (minimum 70%, Missing); spinal cord: 60.7843% (minimum 75%, Missing); thyroid gland: 60.3896% (minimum 65%, Missing)",-0.0461039,-0.342308,-0.349138,0,5,partial,13.9,16.7,6.1,"parathyroid gland: 16.7 nTPM (protected, limit 3); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); spinal cord: 6 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 3); lung: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 3); bone marrow: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135338,LCA5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 68.3824% (minimum 75%, Missing); basal ganglia: 68.8889% (minimum 75%, Missing); bone marrow: 72.6562% (minimum 75%, Missing); cerebral cortex: 68.8889% (minimum 75%, Missing); choroid plexus: 40.0862% (minimum 75%, Missing); hippocampal formation: 67.3913% (minimum 75%, Missing); hypothalamus: 69.9248% (minimum 75%, Missing); lung: 70.4545% (minimum 75%, Missing); midbrain: 69.9248% (minimum 75%, Missing); parathyroid gland: 35.7692% (minimum 70%, Missing); pituitary gland: 72.6562% (minimum 75%, Missing); retina: 41.1504% (minimum 75%, Missing); salivary gland: 63.2653% (minimum 70%, Missing); spinal cord: 60.7843% (minimum 75%, Missing); thyroid gland: 60.3896% (minimum 65%, Missing)",-0.0461039,-0.342308,-0.349138,0,5,partial,13.9,16.7,6.1,"parathyroid gland: 16.7 nTPM (protected, limit 3); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); spinal cord: 6 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 3); lung: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 3); bone marrow: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135338,LCA5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 68.3824% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 68.8889% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 72.6562% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.4545% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.8889% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 40.0862% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.3913% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.9248% (minimum 75%, Baseline (adaptation disabled)); lung: 70.4545% (minimum 75%, Baseline (adaptation disabled)); midbrain: 69.9248% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 35.7692% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.6562% (minimum 75%, Baseline (adaptation disabled)); retina: 41.1504% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.2653% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 69.9248% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 60.7843% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 60.3896% (minimum 65%, Baseline (adaptation disabled))",-0.0461039,-0.342308,-0.349138,0,5,partial,13.9,16.7,6.1,"parathyroid gland: 16.7 nTPM (protected, limit 3); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); spinal cord: 6 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135338,LCA5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 30.0000% (minimum 99%, Missing)",0.05,0.03,-0.69,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135355,GJA10,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 30.0000% (minimum 75%, Missing)",0.35,0.3,-0.45,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135355,GJA10,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 30.0000% (minimum 75%, Missing)",0.35,0.3,-0.45,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135355,GJA10,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 30.0000% (minimum 75%, Missing)",0.35,0.3,-0.45,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135355,GJA10,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 30.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.45,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135355,GJA10,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8938% (minimum 99%, Uncertain); bone marrow: 98.8938% (minimum 99%, Uncertain); choroid plexus: 98.2418% (minimum 99%, Missing); kidney: 98.8938% (minimum 99%, Uncertain); liver: 98.4581% (minimum 99%, Uncertain); pancreas: 96.7532% (minimum 99%, Uncertain); retina: 98.6755% (minimum 99%, Missing); skeletal muscle: 98.6755% (minimum 99%, Uncertain)",0.0259825,0.0102632,-0.0224675,0,3,partial,1.5,0.9,1.1,"pancreas: 1.5 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135436,FAM186B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.325983,0.280263,0.217532,0,3,partial,1.5,0.9,1.1,"pancreas: 1.5 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135436,FAM186B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.325983,0.280263,0.217532,0,3,partial,1.5,0.9,1.1,"pancreas: 1.5 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135436,FAM186B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.325983,0.280263,0.217532,0,3,partial,1.5,0.9,1.1,"pancreas: 1.5 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135436,FAM186B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.325983,0.280263,0.217532,0,3,partial,1.5,0.9,1.1,"pancreas: 1.5 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135436,FAM186B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.2862% (minimum 99%, Missing); bone marrow: 35.9137% (minimum 99%, Missing); cerebral cortex: 98.9510% (minimum 99%, Missing); choroid plexus: 94.3333% (minimum 99%, Missing); colon: 81.3218% (minimum 97%, Missing); duodenum: 76.4865% (minimum 99%, Missing); esophagus: 68.1928% (minimum 97%, Missing); heart muscle: 97.5862% (minimum 99%, Missing); kidney: 96.9178% (minimum 99%, Missing); liver: 94.6488% (minimum 99%, Uncertain); lung: 92.4837% (minimum 99%, Missing); lymph node: 72.0102% (minimum 97%, Missing); midbrain: 98.9510% (minimum 99%, Missing); pancreas: 97.2509% (minimum 99%, Missing); pituitary gland: 98.6063% (minimum 99%, Missing); rectum: 76.0753% (minimum 97%, Missing); retina: 97.9239% (minimum 99%, Missing); salivary gland: 92.1824% (minimum 97%, Missing); skeletal muscle: 98.9510% (minimum 99%, Missing); skin: 79.0503% (minimum 95%, Missing); small intestine: 79.4944% (minimum 99%, Missing); smooth muscle: 91.2903% (minimum 99%, Uncertain); spinal cord: 98.9510% (minimum 99%, Missing); spleen: 80.3977% (minimum 95%, Missing); stomach: 84.4776% (minimum 97%, Missing); thymus: 44.0810% (minimum 95%, Missing); urinary bladder: 94.0199% (minimum 97%, Missing)",-0.50919,-0.288072,-0.630863,0,3,partial,50.5,13.2,35.9,"bone marrow: 50.5 nTPM (vital, limit 1); thymus: 35.9 nTPM (manageable, limit 5); esophagus: 13.2 nTPM (protected, limit 2); lymph node: 11 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); duodenum: 8.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.3 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); colon: 6.5 nTPM (protected, limit 2); stomach: 5.2 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135451,TROAP,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.9137% (minimum 75%, Missing); esophagus: 68.1928% (minimum 70%, Missing); thymus: 44.0810% (minimum 65%, Missing)",-0.20919,-0.0180723,-0.390863,0,3,partial,50.5,13.2,35.9,"bone marrow: 50.5 nTPM (vital, limit 1); thymus: 35.9 nTPM (manageable, limit 5); esophagus: 13.2 nTPM (protected, limit 2); lymph node: 11 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); duodenum: 8.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.3 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); colon: 6.5 nTPM (protected, limit 2); stomach: 5.2 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135451,TROAP,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.9137% (minimum 75%, Missing); esophagus: 68.1928% (minimum 70%, Missing); thymus: 44.0810% (minimum 65%, Missing)",-0.20919,-0.0180723,-0.390863,0,3,partial,50.5,13.2,35.9,"bone marrow: 50.5 nTPM (vital, limit 1); thymus: 35.9 nTPM (manageable, limit 5); esophagus: 13.2 nTPM (protected, limit 3); lymph node: 11 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); duodenum: 8.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.3 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); colon: 6.5 nTPM (protected, limit 3); stomach: 5.2 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135451,TROAP,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.9137% (minimum 75%, Missing); esophagus: 68.1928% (minimum 70%, Missing); thymus: 44.0810% (minimum 65%, Missing)",-0.20919,-0.0180723,-0.390863,0,3,partial,50.5,13.2,35.9,"bone marrow: 50.5 nTPM (vital, limit 1); thymus: 35.9 nTPM (manageable, limit 5); esophagus: 13.2 nTPM (protected, limit 3); lymph node: 11 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); duodenum: 8.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.3 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); colon: 6.5 nTPM (protected, limit 3); stomach: 5.2 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135451,TROAP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.9137% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.1928% (minimum 70%, Baseline (adaptation disabled)); thymus: 44.0810% (minimum 65%, Baseline (adaptation disabled))",-0.20919,-0.0180723,-0.390863,0,3,partial,50.5,13.2,35.9,"bone marrow: 50.5 nTPM (vital, limit 1); thymus: 35.9 nTPM (manageable, limit 5); esophagus: 13.2 nTPM (protected, limit 3); lymph node: 11 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); duodenum: 8.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.3 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); colon: 6.5 nTPM (protected, limit 3); stomach: 5.2 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135451,TROAP,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.6667% (minimum 90%, Approved); adrenal gland: 83.8710% (minimum 99%, Missing); amygdala: 88.1356% (minimum 99%, Missing); basal ganglia: 86.6667% (minimum 99%, Missing); bone marrow: 83.2000% (minimum 99%, Missing); cerebellum: 88.8889% (minimum 99%, Missing); cerebral cortex: 78.7879% (minimum 99%, Missing); choroid plexus: 79.3893% (minimum 99%, Missing); colon: 81.2500% (minimum 97%, Missing); duodenum: 71.7241% (minimum 99%, Missing); esophagus: 87.3950% (minimum 97%, Missing); heart muscle: 70.7483% (minimum 99%, Missing); hippocampal formation: 88.8889% (minimum 99%, Missing); hypothalamus: 89.6552% (minimum 99%, Missing); kidney: 68.4211% (minimum 99%, Missing); liver: 74.2857% (minimum 99%, Missing); lung: 85.9504% (minimum 99%, Missing); lymph node: 85.2459% (minimum 95%, Approved); midbrain: 88.1356% (minimum 99%, Missing); pancreas: 83.8710% (minimum 99%, Missing); parathyroid gland: 67.0968% (minimum 95%, Approved); pituitary gland: 87.3950% (minimum 99%, Missing); rectum: 77.6119% (minimum 97%, Missing); retina: 78.1955% (minimum 99%, Missing); salivary gland: 85.9504% (minimum 97%, Missing); skeletal muscle: 74.8201% (minimum 99%, Missing); skin: 90.4348% (minimum 95%, Missing); small intestine: 78.1955% (minimum 99%, Missing); smooth muscle: 85.9504% (minimum 99%, Missing); spinal cord: 87.3950% (minimum 99%, Missing); spleen: 83.8710% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thymus: 82.5397% (minimum 95%, Missing); thyroid gland: 78.1955% (minimum 95%, Missing); tongue: 72.7273% (minimum 97%, Missing); urinary bladder: 86.6667% (minimum 97%, Missing)",-0.168045,-0.279032,-0.305789,0,5,partial,4.8,5.1,2.9,"parathyroid gland: 5.1 nTPM (protected, limit 4); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135537,AFG1L,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 71.7241% (minimum 75%, Missing); heart muscle: 70.7483% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); liver: 74.2857% (minimum 75%, Missing); skeletal muscle: 74.8201% (minimum 75%, Missing)",0.131955,0.0209677,-0.0657895,0,5,partial,4.8,5.1,2.9,"parathyroid gland: 5.1 nTPM (protected, limit 4); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135537,AFG1L,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 71.7241% (minimum 75%, Missing); heart muscle: 70.7483% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); liver: 74.2857% (minimum 75%, Missing); skeletal muscle: 74.8201% (minimum 75%, Missing)",0.131955,0.0209677,-0.0657895,0,5,partial,4.8,5.1,2.9,"parathyroid gland: 5.1 nTPM (protected, limit 4); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135537,AFG1L,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 71.7241% (minimum 75%, Missing); heart muscle: 70.7483% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); liver: 74.2857% (minimum 75%, Missing); skeletal muscle: 74.8201% (minimum 75%, Missing)",0.131955,0.0209677,-0.0657895,0,5,partial,4.8,5.1,2.9,"parathyroid gland: 5.1 nTPM (protected, limit 4); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135537,AFG1L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 71.7241% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.7483% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.4211% (minimum 75%, Baseline (adaptation disabled)); liver: 74.2857% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 67.0968% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 74.8201% (minimum 75%, Baseline (adaptation disabled))",0.131955,-0.0290323,-0.0657895,0,5,partial,4.8,5.1,2.9,"parathyroid gland: 5.1 nTPM (protected, limit 3); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135537,AFG1L,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 63.6364% (minimum 99%, Missing); cerebral cortex: 87.5000% (minimum 99%, Missing); esophagus: 87.5000% (minimum 97%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing); hypothalamus: 70.0000% (minimum 99%, Missing); midbrain: 87.5000% (minimum 99%, Missing); retina: 77.7778% (minimum 99%, Missing); salivary gland: 87.5000% (minimum 97%, Missing); spinal cord: 87.5000% (minimum 99%, Missing)",0.05,-0.095,-0.353636,0,80,unavailable,0.4,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135577,NMBR,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 63.6364% (minimum 75%, Missing); hypothalamus: 70.0000% (minimum 75%, Missing)",0.35,0.175,-0.113636,0,80,unavailable,0.4,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135577,NMBR,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 63.6364% (minimum 75%, Missing); hypothalamus: 70.0000% (minimum 75%, Missing)",0.35,0.175,-0.113636,0,80,unavailable,0.4,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135577,NMBR,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 63.6364% (minimum 75%, Missing); hypothalamus: 70.0000% (minimum 75%, Missing)",0.35,0.175,-0.113636,0,80,unavailable,0.4,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135577,NMBR,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 63.6364% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 70.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.175,-0.113636,0,80,unavailable,0.4,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135577,NMBR,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.2222% (minimum 99%, Missing); basal ganglia: 25.3333% (minimum 99%, Missing); cerebellum: 16.9643% (minimum 99%, Missing); cerebral cortex: 35.5140% (minimum 99%, Missing); choroid plexus: 95.0000% (minimum 99%, Missing); heart muscle: 92.6829% (minimum 95%, Enhanced); hippocampal formation: 28.1481% (minimum 99%, Missing); hypothalamus: 56.7164% (minimum 99%, Missing); midbrain: 95.0000% (minimum 99%, Missing); pituitary gland: 52.7778% (minimum 99%, Missing); spinal cord: 88.3721% (minimum 99%, Missing)",0.05,0.03,-0.820357,0,0,routine_complete,18.6,0.1,0.2,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),56,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135625,EGR4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.2222% (minimum 75%, Missing); basal ganglia: 25.3333% (minimum 75%, Missing); cerebellum: 16.9643% (minimum 75%, Missing); cerebral cortex: 35.5140% (minimum 75%, Missing); hippocampal formation: 28.1481% (minimum 75%, Missing); hypothalamus: 56.7164% (minimum 75%, Missing); pituitary gland: 52.7778% (minimum 75%, Missing)",0.35,0.3,-0.580357,0,0,routine_complete,18.6,0.1,0.2,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),56,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135625,EGR4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.2222% (minimum 75%, Missing); basal ganglia: 25.3333% (minimum 75%, Missing); cerebellum: 16.9643% (minimum 75%, Missing); cerebral cortex: 35.5140% (minimum 75%, Missing); hippocampal formation: 28.1481% (minimum 75%, Missing); hypothalamus: 56.7164% (minimum 75%, Missing); pituitary gland: 52.7778% (minimum 75%, Missing)",0.35,0.3,-0.580357,0,0,routine_complete,18.6,0.1,0.2,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),56,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135625,EGR4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.2222% (minimum 75%, Missing); basal ganglia: 25.3333% (minimum 75%, Missing); cerebellum: 16.9643% (minimum 75%, Missing); cerebral cortex: 35.5140% (minimum 75%, Missing); hippocampal formation: 28.1481% (minimum 75%, Missing); hypothalamus: 56.7164% (minimum 75%, Missing); pituitary gland: 52.7778% (minimum 75%, Missing)",0.35,0.3,-0.580357,0,0,routine_complete,18.6,0.1,0.2,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),56,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135625,EGR4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.2222% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 25.3333% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 16.9643% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 35.5140% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 28.1481% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 56.7164% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 52.7778% (minimum 75%, Baseline (adaptation disabled))",0.3,0.274359,-0.580357,0,0,routine_complete,18.6,0.1,0.2,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),56,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135625,EGR4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.6842% (minimum 95%, Enhanced); amygdala: 45.1613% (minimum 99%, Missing); basal ganglia: 9.5563% (minimum 99%, Missing); cerebellum: 23.1405% (minimum 99%, Missing); cerebral cortex: 45.9016% (minimum 95%, Enhanced); choroid plexus: 75.6757% (minimum 99%, Missing); colon: 96.5517% (minimum 97%, Missing); hippocampal formation: 54.9020% (minimum 99%, Missing); hypothalamus: 31.4607% (minimum 99%, Missing); midbrain: 25.6881% (minimum 99%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); retina: 8.6687% (minimum 99%, Missing); spinal cord: 40.5797% (minimum 99%, Missing); thyroid gland: 30.4348% (minimum 60%, Enhanced)",-0.295652,-0.00448276,-0.903313,0,7,partial,29.5,0.1,6.4,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135824,RGS8,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 45.1613% (minimum 75%, Missing); basal ganglia: 9.5563% (minimum 75%, Missing); cerebellum: 23.1405% (minimum 75%, Missing); cerebral cortex: 45.9016% (minimum 60%, Enhanced); hippocampal formation: 54.9020% (minimum 75%, Missing); hypothalamus: 31.4607% (minimum 75%, Missing); midbrain: 25.6881% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 8.6687% (minimum 75%, Missing); spinal cord: 40.5797% (minimum 75%, Missing); thyroid gland: 30.4348% (minimum 50%, Enhanced)",-0.195652,0.265517,-0.663313,0,7,partial,29.5,0.1,6.4,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135824,RGS8,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 45.1613% (minimum 75%, Missing); basal ganglia: 9.5563% (minimum 75%, Missing); cerebellum: 23.1405% (minimum 75%, Missing); cerebral cortex: 45.9016% (minimum 60%, Enhanced); hippocampal formation: 54.9020% (minimum 75%, Missing); hypothalamus: 31.4607% (minimum 75%, Missing); midbrain: 25.6881% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 8.6687% (minimum 75%, Missing); spinal cord: 40.5797% (minimum 75%, Missing); thyroid gland: 30.4348% (minimum 50%, Enhanced)",-0.195652,0.265517,-0.663313,0,7,partial,29.5,0.1,6.4,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135824,RGS8,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 45.1613% (minimum 75%, Missing); basal ganglia: 9.5563% (minimum 75%, Missing); cerebellum: 23.1405% (minimum 75%, Missing); cerebral cortex: 45.9016% (minimum 60%, Enhanced); hippocampal formation: 54.9020% (minimum 75%, Missing); hypothalamus: 31.4607% (minimum 75%, Missing); midbrain: 25.6881% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 8.6687% (minimum 75%, Missing); spinal cord: 40.5797% (minimum 75%, Missing); thyroid gland: 30.4348% (minimum 50%, Enhanced)",-0.195652,0.265517,-0.663313,0,7,partial,29.5,0.1,6.4,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135824,RGS8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.6842% (minimum 75%, Baseline (adaptation disabled)); amygdala: 45.1613% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 9.5563% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 23.1405% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 45.9016% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.9020% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 31.4607% (minimum 75%, Baseline (adaptation disabled)); midbrain: 25.6881% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 8.6687% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 40.5797% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 30.4348% (minimum 65%, Baseline (adaptation disabled))",-0.345652,0.265517,-0.663313,0,7,partial,29.5,0.1,6.4,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135824,RGS8,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.9955% (minimum 95%, Missing); adrenal gland: 63.5018% (minimum 99%, Missing); amygdala: 73.6767% (minimum 99%, Missing); basal ganglia: 70.4514% (minimum 99%, Missing); bone marrow: 28.4060% (minimum 99%, Missing); cerebellum: 58.7900% (minimum 99%, Missing); cerebral cortex: 58.0609% (minimum 99%, Missing); choroid plexus: 70.5479% (minimum 99%, Missing); colon: 56.9690% (minimum 97%, Missing); duodenum: 61.8990% (minimum 99%, Missing); esophagus: 62.2733% (minimum 97%, Missing); heart muscle: 65.1899% (minimum 99%, Missing); hippocampal formation: 75.0729% (minimum 99%, Missing); hypothalamus: 73.0496% (minimum 99%, Missing); kidney: 51.6550% (minimum 99%, Missing); liver: 58.9920% (minimum 99%, Missing); lung: 57.9303% (minimum 99%, Missing); lymph node: 48.0859% (minimum 97%, Missing); midbrain: 74.3146% (minimum 99%, Missing); pancreas: 63.5018% (minimum 99%, Missing); parathyroid gland: 43.8298% (minimum 97%, Missing); pituitary gland: 71.5278% (minimum 99%, Missing); rectum: 52.9835% (minimum 97%, Missing); retina: 44.4349% (minimum 99%, Missing); salivary gland: 61.9735% (minimum 97%, Missing); skeletal muscle: 63.8166% (minimum 99%, Missing); skin: 62.9584% (minimum 95%, Missing); small intestine: 59.3318% (minimum 99%, Missing); smooth muscle: 51.2948% (minimum 99%, Missing); spinal cord: 69.7832% (minimum 99%, Missing); spleen: 56.4074% (minimum 95%, Missing); stomach: 60.5170% (minimum 97%, Missing); thymus: 37.3730% (minimum 95%, Missing); thyroid gland: 52.4975% (minimum 95%, Missing); tongue: 58.6560% (minimum 97%, Missing); urinary bladder: 49.7585% (minimum 97%, Missing)",-0.57627,-0.531702,-0.70594,0,4,partial,129.8,66,86.3,"bone marrow: 129.8 nTPM (vital, limit 1); thymus: 86.3 nTPM (manageable, limit 5); parathyroid gland: 66 nTPM (protected, limit 2); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 2); urinary bladder: 52 nTPM (protected, limit 2); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (manageable, limit 5); rectum: 45.7 nTPM (protected, limit 2); spleen: 39.8 nTPM (manageable, limit 5); colon: 38.9 nTPM (protected, limit 2); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (manageable, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 2); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 2); duodenum: 31.7 nTPM (vital, limit 1); salivary gland: 31.6 nTPM (protected, limit 2); esophagus: 31.2 nTPM (protected, limit 2); skin: 30.3 nTPM (manageable, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135829,DHX9,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.9955% (minimum 65%, Missing); adrenal gland: 63.5018% (minimum 75%, Missing); amygdala: 73.6767% (minimum 75%, Missing); basal ganglia: 70.4514% (minimum 75%, Missing); bone marrow: 28.4060% (minimum 75%, Missing); cerebellum: 58.7900% (minimum 75%, Missing); cerebral cortex: 58.0609% (minimum 75%, Missing); choroid plexus: 70.5479% (minimum 75%, Missing); colon: 56.9690% (minimum 70%, Missing); duodenum: 61.8990% (minimum 75%, Missing); esophagus: 62.2733% (minimum 70%, Missing); heart muscle: 65.1899% (minimum 75%, Missing); hypothalamus: 73.0496% (minimum 75%, Missing); kidney: 51.6550% (minimum 75%, Missing); liver: 58.9920% (minimum 75%, Missing); lung: 57.9303% (minimum 75%, Missing); lymph node: 48.0859% (minimum 70%, Missing); midbrain: 74.3146% (minimum 75%, Missing); pancreas: 63.5018% (minimum 75%, Missing); parathyroid gland: 43.8298% (minimum 70%, Missing); pituitary gland: 71.5278% (minimum 75%, Missing); rectum: 52.9835% (minimum 70%, Missing); retina: 44.4349% (minimum 75%, Missing); salivary gland: 61.9735% (minimum 70%, Missing); skeletal muscle: 63.8166% (minimum 75%, Missing); skin: 62.9584% (minimum 65%, Missing); small intestine: 59.3318% (minimum 75%, Missing); smooth muscle: 51.2948% (minimum 75%, Missing); spinal cord: 69.7832% (minimum 75%, Missing); spleen: 56.4074% (minimum 65%, Missing); stomach: 60.5170% (minimum 70%, Missing); thymus: 37.3730% (minimum 65%, Missing); thyroid gland: 52.4975% (minimum 65%, Missing); tongue: 58.6560% (minimum 70%, Missing); urinary bladder: 49.7585% (minimum 70%, Missing)",-0.27627,-0.261702,-0.46594,0,4,partial,129.8,66,86.3,"bone marrow: 129.8 nTPM (vital, limit 1); thymus: 86.3 nTPM (manageable, limit 5); parathyroid gland: 66 nTPM (protected, limit 2); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 2); urinary bladder: 52 nTPM (protected, limit 2); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (manageable, limit 5); rectum: 45.7 nTPM (protected, limit 2); spleen: 39.8 nTPM (manageable, limit 5); colon: 38.9 nTPM (protected, limit 2); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (manageable, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 2); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 2); duodenum: 31.7 nTPM (vital, limit 1); salivary gland: 31.6 nTPM (protected, limit 2); esophagus: 31.2 nTPM (protected, limit 2); skin: 30.3 nTPM (manageable, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135829,DHX9,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.9955% (minimum 65%, Missing); adrenal gland: 63.5018% (minimum 75%, Missing); amygdala: 73.6767% (minimum 75%, Missing); basal ganglia: 70.4514% (minimum 75%, Missing); bone marrow: 28.4060% (minimum 75%, Missing); cerebellum: 58.7900% (minimum 75%, Missing); cerebral cortex: 58.0609% (minimum 75%, Missing); choroid plexus: 70.5479% (minimum 75%, Missing); colon: 56.9690% (minimum 70%, Missing); duodenum: 61.8990% (minimum 75%, Missing); esophagus: 62.2733% (minimum 70%, Missing); heart muscle: 65.1899% (minimum 75%, Missing); hypothalamus: 73.0496% (minimum 75%, Missing); kidney: 51.6550% (minimum 75%, Missing); liver: 58.9920% (minimum 75%, Missing); lung: 57.9303% (minimum 75%, Missing); lymph node: 48.0859% (minimum 70%, Missing); midbrain: 74.3146% (minimum 75%, Missing); pancreas: 63.5018% (minimum 75%, Missing); parathyroid gland: 43.8298% (minimum 70%, Missing); pituitary gland: 71.5278% (minimum 75%, Missing); rectum: 52.9835% (minimum 70%, Missing); retina: 44.4349% (minimum 75%, Missing); salivary gland: 61.9735% (minimum 70%, Missing); skeletal muscle: 63.8166% (minimum 75%, Missing); skin: 62.9584% (minimum 65%, Missing); small intestine: 59.3318% (minimum 75%, Missing); smooth muscle: 51.2948% (minimum 75%, Missing); spinal cord: 69.7832% (minimum 75%, Missing); spleen: 56.4074% (minimum 65%, Missing); stomach: 60.5170% (minimum 70%, Missing); thymus: 37.3730% (minimum 65%, Missing); thyroid gland: 52.4975% (minimum 65%, Missing); tongue: 58.6560% (minimum 70%, Missing); urinary bladder: 49.7585% (minimum 70%, Missing)",-0.27627,-0.261702,-0.46594,0,4,partial,129.8,66,86.3,"bone marrow: 129.8 nTPM (vital, limit 1); thymus: 86.3 nTPM (manageable, limit 5); parathyroid gland: 66 nTPM (protected, limit 3); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 3); urinary bladder: 52 nTPM (protected, limit 3); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (manageable, limit 5); rectum: 45.7 nTPM (protected, limit 3); spleen: 39.8 nTPM (manageable, limit 5); colon: 38.9 nTPM (protected, limit 3); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (manageable, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 3); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 3); duodenum: 31.7 nTPM (vital, limit 1); salivary gland: 31.6 nTPM (protected, limit 3); esophagus: 31.2 nTPM (protected, limit 3); skin: 30.3 nTPM (manageable, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135829,DHX9,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.9955% (minimum 65%, Missing); adrenal gland: 63.5018% (minimum 75%, Missing); amygdala: 73.6767% (minimum 75%, Missing); basal ganglia: 70.4514% (minimum 75%, Missing); bone marrow: 28.4060% (minimum 75%, Missing); cerebellum: 58.7900% (minimum 75%, Missing); cerebral cortex: 58.0609% (minimum 75%, Missing); choroid plexus: 70.5479% (minimum 75%, Missing); colon: 56.9690% (minimum 70%, Missing); duodenum: 61.8990% (minimum 75%, Missing); esophagus: 62.2733% (minimum 70%, Missing); heart muscle: 65.1899% (minimum 75%, Missing); hypothalamus: 73.0496% (minimum 75%, Missing); kidney: 51.6550% (minimum 75%, Missing); liver: 58.9920% (minimum 75%, Missing); lung: 57.9303% (minimum 75%, Missing); lymph node: 48.0859% (minimum 70%, Missing); midbrain: 74.3146% (minimum 75%, Missing); pancreas: 63.5018% (minimum 75%, Missing); parathyroid gland: 43.8298% (minimum 70%, Missing); pituitary gland: 71.5278% (minimum 75%, Missing); rectum: 52.9835% (minimum 70%, Missing); retina: 44.4349% (minimum 75%, Missing); salivary gland: 61.9735% (minimum 70%, Missing); skeletal muscle: 63.8166% (minimum 75%, Missing); skin: 62.9584% (minimum 65%, Missing); small intestine: 59.3318% (minimum 75%, Missing); smooth muscle: 51.2948% (minimum 75%, Missing); spinal cord: 69.7832% (minimum 75%, Missing); spleen: 56.4074% (minimum 65%, Missing); stomach: 60.5170% (minimum 70%, Missing); thymus: 37.3730% (minimum 65%, Missing); thyroid gland: 52.4975% (minimum 65%, Missing); tongue: 58.6560% (minimum 70%, Missing); urinary bladder: 49.7585% (minimum 70%, Missing)",-0.27627,-0.261702,-0.46594,0,4,partial,129.8,66,86.3,"bone marrow: 129.8 nTPM (vital, limit 1); thymus: 86.3 nTPM (manageable, limit 5); parathyroid gland: 66 nTPM (protected, limit 3); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 3); urinary bladder: 52 nTPM (protected, limit 3); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (manageable, limit 5); rectum: 45.7 nTPM (protected, limit 3); spleen: 39.8 nTPM (manageable, limit 5); colon: 38.9 nTPM (protected, limit 3); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (manageable, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 3); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 3); duodenum: 31.7 nTPM (vital, limit 1); salivary gland: 31.6 nTPM (protected, limit 3); esophagus: 31.2 nTPM (protected, limit 3); skin: 30.3 nTPM (manageable, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135829,DHX9,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.9955% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.5018% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.6767% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.4514% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 28.4060% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 58.7900% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.0609% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.5479% (minimum 75%, Baseline (adaptation disabled)); colon: 56.9690% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.8990% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.2733% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.1899% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.0496% (minimum 75%, Baseline (adaptation disabled)); kidney: 51.6550% (minimum 75%, Baseline (adaptation disabled)); liver: 58.9920% (minimum 75%, Baseline (adaptation disabled)); lung: 57.9303% (minimum 75%, Baseline (adaptation disabled)); lymph node: 48.0859% (minimum 70%, Baseline (adaptation disabled)); midbrain: 74.3146% (minimum 75%, Baseline (adaptation disabled)); pancreas: 63.5018% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 43.8298% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.5278% (minimum 75%, Baseline (adaptation disabled)); rectum: 52.9835% (minimum 70%, Baseline (adaptation disabled)); retina: 44.4349% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.9735% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 63.8166% (minimum 75%, Baseline (adaptation disabled)); skin: 62.9584% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.3318% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 51.2948% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.7832% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.4074% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.5170% (minimum 70%, Baseline (adaptation disabled)); thymus: 37.3730% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.4975% (minimum 65%, Baseline (adaptation disabled)); tongue: 58.6560% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 49.7585% (minimum 70%, Baseline (adaptation disabled))",-0.27627,-0.261702,-0.46594,0,4,partial,129.8,66,86.3,"bone marrow: 129.8 nTPM (vital, limit 1); thymus: 86.3 nTPM (manageable, limit 5); parathyroid gland: 66 nTPM (protected, limit 3); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 3); urinary bladder: 52 nTPM (protected, limit 3); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (manageable, limit 5); rectum: 45.7 nTPM (protected, limit 3); spleen: 39.8 nTPM (manageable, limit 5); colon: 38.9 nTPM (protected, limit 3); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (manageable, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 3); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 3); duodenum: 31.7 nTPM (vital, limit 1); salivary gland: 31.6 nTPM (protected, limit 3); esophagus: 31.2 nTPM (protected, limit 3); skin: 30.3 nTPM (manageable, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135829,DHX9,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.7447% (minimum 99%, Missing); basal ganglia: 56.2500% (minimum 99%, Missing); bone marrow: 95.7447% (minimum 99%, Missing); cerebral cortex: 86.5385% (minimum 99%, Missing); colon: 84.9057% (minimum 97%, Missing); duodenum: 77.5862% (minimum 99%, Missing); esophagus: 90.0000% (minimum 97%, Missing); heart muscle: 97.8261% (minimum 99%, Missing); hippocampal formation: 93.7500% (minimum 99%, Missing); hypothalamus: 93.7500% (minimum 99%, Missing); liver: 95.7447% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); lymph node: 61.6438% (minimum 97%, Missing); midbrain: 97.8261% (minimum 99%, Missing); pituitary gland: 91.8367% (minimum 99%, Missing); rectum: 84.9057% (minimum 97%, Missing); salivary gland: 81.8182% (minimum 97%, Missing); skin: 91.8367% (minimum 95%, Missing); small intestine: 68.1818% (minimum 99%, Missing); smooth muscle: 97.8261% (minimum 99%, Missing); spinal cord: 97.8261% (minimum 99%, Missing); spleen: 52.9412% (minimum 95%, Missing); stomach: 86.5385% (minimum 97%, Missing); thymus: 70.3125% (minimum 95%, Missing); urinary bladder: 84.9057% (minimum 97%, Missing)",-0.420588,-0.353562,-0.4275,0,80,unavailable,3.5,2.8,4,"basal ganglia: 3.5 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135898,GPR55,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 56.2500% (minimum 75%, Missing); lymph node: 61.6438% (minimum 70%, Missing); small intestine: 68.1818% (minimum 75%, Missing); spleen: 52.9412% (minimum 65%, Missing)",-0.120588,-0.0835616,-0.1875,0,80,unavailable,3.5,2.8,4,"basal ganglia: 3.5 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135898,GPR55,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 56.2500% (minimum 75%, Missing); lymph node: 61.6438% (minimum 70%, Missing); small intestine: 68.1818% (minimum 75%, Missing); spleen: 52.9412% (minimum 65%, Missing)",-0.120588,-0.0835616,-0.1875,0,80,unavailable,3.5,2.8,4,"basal ganglia: 3.5 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135898,GPR55,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 56.2500% (minimum 75%, Missing); lymph node: 61.6438% (minimum 70%, Missing); small intestine: 68.1818% (minimum 75%, Missing); spleen: 52.9412% (minimum 65%, Missing)",-0.120588,-0.0835616,-0.1875,0,80,unavailable,3.5,2.8,4,"basal ganglia: 3.5 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135898,GPR55,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 56.2500% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.6438% (minimum 70%, Baseline (adaptation disabled)); small intestine: 68.1818% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.9412% (minimum 65%, Baseline (adaptation disabled))",-0.120588,-0.0835616,-0.1875,0,80,unavailable,3.5,2.8,4,"basal ganglia: 3.5 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135898,GPR55,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.5503% (minimum 95%, Missing); adrenal gland: 75.4601% (minimum 99%, Missing); amygdala: 93.1818% (minimum 99%, Missing); basal ganglia: 92.4812% (minimum 99%, Missing); bone marrow: 51.6807% (minimum 98%, Approved); cerebellum: 82.0000% (minimum 99%, Missing); cerebral cortex: 76.8750% (minimum 99%, Missing); choroid plexus: 89.7810% (minimum 99%, Missing); colon: 80.9211% (minimum 97%, Missing); duodenum: 80.9211% (minimum 99%, Missing); esophagus: 76.3975% (minimum 97%, Missing); heart muscle: 84.8276% (minimum 99%, Missing); hippocampal formation: 93.1818% (minimum 99%, Missing); hypothalamus: 93.1818% (minimum 99%, Missing); kidney: 81.4570% (minimum 99%, Missing); liver: 76.8750% (minimum 99%, Missing); lung: 80.9211% (minimum 99%, Missing); lymph node: 67.9558% (minimum 97%, Missing); midbrain: 93.1818% (minimum 99%, Missing); pancreas: 80.9211% (minimum 99%, Missing); parathyroid gland: 76.3975% (minimum 97%, Missing); pituitary gland: 89.7810% (minimum 99%, Missing); rectum: 78.3439% (minimum 97%, Missing); retina: 58.8517% (minimum 99%, Missing); salivary gland: 76.8750% (minimum 97%, Missing); skeletal muscle: 82.0000% (minimum 98%, Approved); skin: 76.8750% (minimum 95%, Missing); small intestine: 78.8462% (minimum 99%, Missing); smooth muscle: 79.8701% (minimum 99%, Missing); spinal cord: 86.6197% (minimum 99%, Missing); spleen: 76.8750% (minimum 90%, Approved); stomach: 78.8462% (minimum 97%, Missing); thymus: 66.8478% (minimum 95%, Missing); thyroid gland: 71.9298% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 77.8481% (minimum 97%, Missing)",-0.281522,-0.290442,-0.463193,0,6,partial,11.5,5.8,6.1,"bone marrow: 11.5 nTPM (vital, limit 2); retina: 8.6 nTPM (vital, limit 1); thymus: 6.1 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 2); tongue: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 2); liver: 3.7 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); small intestine: 3.3 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135913,USP37,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 51.6807% (minimum 70%, Approved); lymph node: 67.9558% (minimum 70%, Missing); retina: 58.8517% (minimum 75%, Missing)",0.0184783,-0.020442,-0.183193,0,6,partial,11.5,5.8,6.1,"bone marrow: 11.5 nTPM (vital, limit 2); retina: 8.6 nTPM (vital, limit 1); thymus: 6.1 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 2); tongue: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 2); liver: 3.7 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); small intestine: 3.3 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135913,USP37,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 51.6807% (minimum 70%, Approved); lymph node: 67.9558% (minimum 70%, Missing); retina: 58.8517% (minimum 75%, Missing)",0.0184783,-0.020442,-0.183193,0,6,partial,11.5,5.8,6.1,"bone marrow: 11.5 nTPM (vital, limit 2); retina: 8.6 nTPM (vital, limit 1); thymus: 6.1 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); tongue: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); esophagus: 3.8 nTPM (protected, limit 3); liver: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 3); cerebral cortex: 3.7 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); small intestine: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135913,USP37,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 51.6807% (minimum 70%, Approved); lymph node: 67.9558% (minimum 70%, Missing); retina: 58.8517% (minimum 75%, Missing)",0.0184783,-0.020442,-0.183193,0,6,partial,11.5,5.8,6.1,"bone marrow: 11.5 nTPM (vital, limit 2); retina: 8.6 nTPM (vital, limit 1); thymus: 6.1 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); tongue: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); esophagus: 3.8 nTPM (protected, limit 3); liver: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 3); cerebral cortex: 3.7 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); small intestine: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135913,USP37,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 51.6807% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.9558% (minimum 70%, Baseline (adaptation disabled)); retina: 58.8517% (minimum 75%, Baseline (adaptation disabled))",0.0184783,-0.020442,-0.233193,0,6,partial,11.5,5.8,6.1,"bone marrow: 11.5 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); thymus: 6.1 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); tongue: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); esophagus: 3.8 nTPM (protected, limit 3); liver: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 3); cerebral cortex: 3.7 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); small intestine: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135913,USP37,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2353% (minimum 99%, Missing); amygdala: 97.8516% (minimum 99%, Missing); basal ganglia: 97.4708% (minimum 99%, Missing); bone marrow: 98.6220% (minimum 99%, Missing); cerebral cortex: 98.6220% (minimum 99%, Missing); choroid plexus: 94.1729% (minimum 99%, Missing); duodenum: 98.0431% (minimum 99%, Missing); hippocampal formation: 96.3462% (minimum 99%, Missing); hypothalamus: 96.9052% (minimum 99%, Missing); kidney: 94.3503% (minimum 99%, Missing); lung: 96.9052% (minimum 99%, Missing); midbrain: 97.4708% (minimum 99%, Missing); pancreas: 96.7181% (minimum 99%, Missing); pituitary gland: 95.4286% (minimum 99%, Missing); retina: 95.2471% (minimum 99%, Missing); small intestine: 98.8166% (minimum 99%, Missing); spinal cord: 97.0930% (minimum 99%, Missing); thyroid gland: 94.3503% (minimum 95%, Missing)",-0.00649718,0.000930233,-0.0482707,0,80,unavailable,3.1,1.5,3,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135951,TSGA10,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.293503,0.27093,0.191729,0,80,unavailable,3.1,1.5,3,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135951,TSGA10,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.293503,0.27093,0.191729,0,80,unavailable,3.1,1.5,3,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135951,TSGA10,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.293503,0.27093,0.191729,0,80,unavailable,3.1,1.5,3,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135951,TSGA10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.293503,0.27093,0.191729,0,80,unavailable,3.1,1.5,3,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135951,TSGA10,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 82.3529% (minimum 99%, Missing); colon: 53.8462% (minimum 97%, Missing); duodenum: 58.3333% (minimum 99%, Missing); esophagus: 28.5714% (minimum 97%, Missing); kidney: 70.0000% (minimum 99%, Missing); liver: 60.8696% (minimum 99%, Missing); lung: 87.5000% (minimum 99%, Missing); lymph node: 48.2759% (minimum 97%, Missing); pancreas: 93.3333% (minimum 99%, Missing); rectum: 42.4242% (minimum 97%, Missing); salivary gland: 73.6842% (minimum 97%, Missing); skin: 50.0000% (minimum 95%, Missing); small intestine: 58.3333% (minimum 99%, Missing); spleen: 87.5000% (minimum 95%, Missing); stomach: 63.6364% (minimum 97%, Missing); thymus: 56.0000% (minimum 95%, Missing); urinary bladder: 50.0000% (minimum 97%, Missing)",-0.45,-0.684286,-0.406667,0,4,partial,1,3.5,1.4,"esophagus: 3.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135960,EDAR,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"colon: 53.8462% (minimum 70%, Missing); duodenum: 58.3333% (minimum 75%, Missing); esophagus: 28.5714% (minimum 70%, Missing); kidney: 70.0000% (minimum 75%, Missing); liver: 60.8696% (minimum 75%, Missing); lymph node: 48.2759% (minimum 70%, Missing); rectum: 42.4242% (minimum 70%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 58.3333% (minimum 75%, Missing); stomach: 63.6364% (minimum 70%, Missing); thymus: 56.0000% (minimum 65%, Missing); urinary bladder: 50.0000% (minimum 70%, Missing)",-0.15,-0.414286,-0.166667,0,4,partial,1,3.5,1.4,"esophagus: 3.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135960,EDAR,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"colon: 53.8462% (minimum 70%, Missing); duodenum: 58.3333% (minimum 75%, Missing); esophagus: 28.5714% (minimum 70%, Missing); kidney: 70.0000% (minimum 75%, Missing); liver: 60.8696% (minimum 75%, Missing); lymph node: 48.2759% (minimum 70%, Missing); rectum: 42.4242% (minimum 70%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 58.3333% (minimum 75%, Missing); stomach: 63.6364% (minimum 70%, Missing); thymus: 56.0000% (minimum 65%, Missing); urinary bladder: 50.0000% (minimum 70%, Missing)",-0.15,-0.414286,-0.166667,0,4,partial,1,3.5,1.4,"esophagus: 3.5 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135960,EDAR,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"colon: 53.8462% (minimum 70%, Missing); duodenum: 58.3333% (minimum 75%, Missing); esophagus: 28.5714% (minimum 70%, Missing); kidney: 70.0000% (minimum 75%, Missing); liver: 60.8696% (minimum 75%, Missing); lymph node: 48.2759% (minimum 70%, Missing); rectum: 42.4242% (minimum 70%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 58.3333% (minimum 75%, Missing); stomach: 63.6364% (minimum 70%, Missing); thymus: 56.0000% (minimum 65%, Missing); urinary bladder: 50.0000% (minimum 70%, Missing)",-0.15,-0.414286,-0.166667,0,4,partial,1,3.5,1.4,"esophagus: 3.5 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135960,EDAR,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"colon: 53.8462% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.3333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 28.5714% (minimum 70%, Baseline (adaptation disabled)); kidney: 70.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 60.8696% (minimum 75%, Baseline (adaptation disabled)); lymph node: 48.2759% (minimum 70%, Baseline (adaptation disabled)); rectum: 42.4242% (minimum 70%, Baseline (adaptation disabled)); skin: 50.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 58.3333% (minimum 75%, Baseline (adaptation disabled)); stomach: 63.6364% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.0000% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 50.0000% (minimum 70%, Baseline (adaptation disabled))",-0.15,-0.414286,-0.166667,0,4,partial,1,3.5,1.4,"esophagus: 3.5 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000135960,EDAR,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9167% (minimum 99%, Missing); amygdala: 98.3264% (minimum 99%, Missing); basal ganglia: 98.7395% (minimum 99%, Missing); bone marrow: 98.7395% (minimum 99%, Missing); cerebellum: 85.7664% (minimum 99%, Missing); cerebral cortex: 98.3264% (minimum 99%, Missing); colon: 95.5285% (minimum 97%, Missing); heart muscle: 97.9167% (minimum 99%, Missing); hippocampal formation: 98.3264% (minimum 99%, Missing); hypothalamus: 98.7395% (minimum 99%, Missing); kidney: 94.7581% (minimum 99%, Missing); lung: 86.3971% (minimum 99%, Missing); lymph node: 95.9184% (minimum 97%, Missing); midbrain: 98.7395% (minimum 99%, Missing); pancreas: 91.0853% (minimum 99%, Missing); parathyroid gland: 93.6255% (minimum 97%, Missing); pituitary gland: 95.1417% (minimum 99%, Missing); retina: 93.6255% (minimum 99%, Missing); salivary gland: 95.9184% (minimum 97%, Missing); small intestine: 96.7078% (minimum 99%, Missing); smooth muscle: 96.7078% (minimum 99%, Missing); spinal cord: 98.7395% (minimum 99%, Missing); spleen: 94.0000% (minimum 95%, Missing); thymus: 86.7159% (minimum 95%, Missing)",-0.0828413,-0.033745,-0.132336,0,80,unavailable,3.9,1.6,3.6,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136014,USP44,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.217159,0.236255,0.107664,0,80,unavailable,3.9,1.6,3.6,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136014,USP44,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.217159,0.236255,0.107664,0,80,unavailable,3.9,1.6,3.6,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136014,USP44,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.217159,0.236255,0.107664,0,80,unavailable,3.9,1.6,3.6,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136014,USP44,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.217159,0.236255,0.107664,0,80,unavailable,3.9,1.6,3.6,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136014,USP44,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.0851% (minimum 95%, Missing); adrenal gland: 71.1111% (minimum 99%, Missing); amygdala: 64.0000% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 84.2105% (minimum 99%, Missing); cerebellum: 65.3061% (minimum 99%, Missing); cerebral cortex: 61.5385% (minimum 99%, Missing); choroid plexus: 65.3061% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 91.4286% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 61.5385% (minimum 99%, Missing); hippocampal formation: 65.3061% (minimum 99%, Missing); hypothalamus: 60.3774% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); liver: 69.5652% (minimum 99%, Missing); lung: 69.5652% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 59.2593% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 54.2373% (minimum 97%, Missing); pituitary gland: 69.5652% (minimum 99%, Missing); rectum: 78.0488% (minimum 97%, Missing); retina: 68.0851% (minimum 99%, Missing); salivary gland: 68.0851% (minimum 97%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 74.4186% (minimum 95%, Missing); small intestine: 72.7273% (minimum 99%, Missing); smooth muscle: 65.3061% (minimum 98%, Approved); spinal cord: 59.2593% (minimum 99%, Missing); spleen: 65.3061% (minimum 95%, Missing); stomach: 64.0000% (minimum 97%, Missing); thymus: 68.0851% (minimum 95%, Missing); thyroid gland: 54.2373% (minimum 95%, Missing); tongue: 62.7451% (minimum 97%, Missing); urinary bladder: 74.4186% (minimum 97%, Missing)",-0.407627,-0.427627,-0.418571,0,2,partial,2.4,2.7,2.7,"parathyroid gland: 2.7 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136197,C7orf25,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.1111% (minimum 75%, Missing); amygdala: 64.0000% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 65.3061% (minimum 75%, Missing); cerebral cortex: 61.5385% (minimum 75%, Missing); choroid plexus: 65.3061% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 65.3061% (minimum 75%, Missing); hypothalamus: 60.3774% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 69.5652% (minimum 75%, Missing); lung: 69.5652% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 59.2593% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 54.2373% (minimum 70%, Missing); pituitary gland: 69.5652% (minimum 75%, Missing); retina: 68.0851% (minimum 75%, Missing); salivary gland: 68.0851% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); smooth muscle: 65.3061% (minimum 70%, Approved); spinal cord: 59.2593% (minimum 75%, Missing); stomach: 64.0000% (minimum 70%, Missing); thyroid gland: 54.2373% (minimum 65%, Missing); tongue: 62.7451% (minimum 70%, Missing)",-0.107627,-0.157627,-0.178571,0,2,partial,2.4,2.7,2.7,"parathyroid gland: 2.7 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136197,C7orf25,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.1111% (minimum 75%, Missing); amygdala: 64.0000% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 65.3061% (minimum 75%, Missing); cerebral cortex: 61.5385% (minimum 75%, Missing); choroid plexus: 65.3061% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 65.3061% (minimum 75%, Missing); hypothalamus: 60.3774% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 69.5652% (minimum 75%, Missing); lung: 69.5652% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 59.2593% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 54.2373% (minimum 70%, Missing); pituitary gland: 69.5652% (minimum 75%, Missing); retina: 68.0851% (minimum 75%, Missing); salivary gland: 68.0851% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); smooth muscle: 65.3061% (minimum 70%, Approved); spinal cord: 59.2593% (minimum 75%, Missing); stomach: 64.0000% (minimum 70%, Missing); thyroid gland: 54.2373% (minimum 65%, Missing); tongue: 62.7451% (minimum 70%, Missing)",-0.107627,-0.157627,-0.178571,0,2,partial,2.4,2.7,2.7,"kidney: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136197,C7orf25,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.1111% (minimum 75%, Missing); amygdala: 64.0000% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 65.3061% (minimum 75%, Missing); cerebral cortex: 61.5385% (minimum 75%, Missing); choroid plexus: 65.3061% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 65.3061% (minimum 75%, Missing); hypothalamus: 60.3774% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 69.5652% (minimum 75%, Missing); lung: 69.5652% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 59.2593% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 54.2373% (minimum 70%, Missing); pituitary gland: 69.5652% (minimum 75%, Missing); retina: 68.0851% (minimum 75%, Missing); salivary gland: 68.0851% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); smooth muscle: 65.3061% (minimum 70%, Approved); spinal cord: 59.2593% (minimum 75%, Missing); stomach: 64.0000% (minimum 70%, Missing); thyroid gland: 54.2373% (minimum 65%, Missing); tongue: 62.7451% (minimum 70%, Missing)",-0.107627,-0.157627,-0.178571,0,2,partial,2.4,2.7,2.7,"kidney: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136197,C7orf25,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.1111% (minimum 75%, Baseline (adaptation disabled)); amygdala: 64.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.3061% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.5385% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 65.3061% (minimum 75%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 70%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 61.5385% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.3061% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.3774% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 75%, Baseline (adaptation disabled)); liver: 69.5652% (minimum 75%, Baseline (adaptation disabled)); lung: 69.5652% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); midbrain: 59.2593% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 54.2373% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.5652% (minimum 75%, Baseline (adaptation disabled)); retina: 68.0851% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.0851% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.7273% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.3061% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.2593% (minimum 75%, Baseline (adaptation disabled)); stomach: 64.0000% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 54.2373% (minimum 65%, Baseline (adaptation disabled)); tongue: 62.7451% (minimum 70%, Baseline (adaptation disabled))",-0.107627,-0.157627,-0.178571,0,2,partial,2.4,2.7,2.7,"kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136197,C7orf25,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.5294% (minimum 99%, Missing); basal ganglia: 98.5294% (minimum 99%, Missing); bone marrow: 81.7073% (minimum 97%, Supported); duodenum: 93.0556% (minimum 97%, Supported); hippocampal formation: 98.5294% (minimum 99%, Missing); hypothalamus: 98.5294% (minimum 99%, Missing); midbrain: 98.5294% (minimum 99%, Missing); pancreas: 95.7143% (minimum 97%, Supported); pituitary gland: 97.1014% (minimum 99%, Missing); retina: 91.7808% (minimum 99%, Missing); skeletal muscle: 83.7500% (minimum 97%, Supported); small intestine: 91.7808% (minimum 97%, Supported); spinal cord: 98.5294% (minimum 99%, Missing)",0.0481013,0.0178082,-0.152927,0,3,partial,1.5,0.6,1.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136206,SPDYE1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.298101,0.3,0.167073,0,3,partial,1.5,0.6,1.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136206,SPDYE1,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.298101,0.3,0.167073,0,3,partial,1.5,0.6,1.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136206,SPDYE1,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.298101,0.3,0.167073,0,3,partial,1.5,0.6,1.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136206,SPDYE1,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.198101,0.217808,0.0670732,0,3,partial,1.5,0.6,1.2,"bone marrow: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136206,SPDYE1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 97.5524% (minimum 99%, Missing); lymph node: 87.1875% (minimum 97%, Missing); thymus: 94.8980% (minimum 95%, Missing)",-0.00102041,-0.098125,-0.0144755,0,4,partial,0.7,4.1,1.5,"lymph node: 4.1 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136231,IGF2BP3,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.29898,0.171875,0.225524,0,4,partial,0.7,4.1,1.5,"lymph node: 4.1 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136231,IGF2BP3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.29898,0.171875,0.225524,0,4,partial,0.7,4.1,1.5,"lymph node: 4.1 nTPM (protected, limit 3)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136231,IGF2BP3,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.29898,0.171875,0.225524,0,4,partial,0.7,4.1,1.5,"lymph node: 4.1 nTPM (protected, limit 3)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136231,IGF2BP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.29898,0.171875,0.225524,0,4,partial,0.7,4.1,1.5,"lymph node: 4.1 nTPM (protected, limit 3)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136231,IGF2BP3,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.7179% (minimum 99%, Missing); basal ganglia: 96.2500% (minimum 99%, Missing); cerebral cortex: 98.7179% (minimum 99%, Missing); esophagus: 75.4902% (minimum 97%, Missing); hippocampal formation: 97.4684% (minimum 99%, Missing); hypothalamus: 84.6154% (minimum 99%, Missing); lung: 96.2500% (minimum 99%, Missing); midbrain: 84.6154% (minimum 99%, Missing); pituitary gland: 87.5000% (minimum 99%, Missing); spinal cord: 50.3268% (minimum 99%, Missing); thyroid gland: 84.6154% (minimum 95%, Missing)",-0.103846,-0.215098,-0.486732,0,80,unavailable,7.6,2.5,1.4,"spinal cord: 7.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136327,NKX2-8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 50.3268% (minimum 75%, Missing)",0.196154,0.054902,-0.246732,0,80,unavailable,7.6,2.5,1.4,"spinal cord: 7.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136327,NKX2-8,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 50.3268% (minimum 75%, Missing)",0.196154,0.054902,-0.246732,0,80,unavailable,7.6,2.5,1.4,"spinal cord: 7.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136327,NKX2-8,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 50.3268% (minimum 75%, Missing)",0.196154,0.054902,-0.246732,0,80,unavailable,7.6,2.5,1.4,"spinal cord: 7.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136327,NKX2-8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 50.3268% (minimum 75%, Baseline (adaptation disabled))",0.196154,0.054902,-0.246732,0,80,unavailable,7.6,2.5,1.4,"spinal cord: 7.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136327,NKX2-8,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.1366% (minimum 99%, Missing); choroid plexus: 92.6686% (minimum 99%, Missing); hippocampal formation: 98.9045% (minimum 99%, Missing); hypothalamus: 98.9045% (minimum 99%, Missing); pituitary gland: 98.7500% (minimum 99%, Missing); retina: 98.4424% (minimum 99%, Missing)",0.0390454,0.0159594,-0.0633138,0,6,partial,5,0.9,1,"choroid plexus: 5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136449,MYCBPAP,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.339045,0.285959,0.176686,0,6,partial,5,0.9,1,"choroid plexus: 5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136449,MYCBPAP,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.339045,0.285959,0.176686,0,6,partial,5,0.9,1,"choroid plexus: 5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136449,MYCBPAP,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.339045,0.285959,0.176686,0,6,partial,5,0.9,1,"choroid plexus: 5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136449,MYCBPAP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.334424,0.285959,0.176686,0,6,partial,5,0.9,1,"choroid plexus: 5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136449,MYCBPAP,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pituitary gland: 55.4114% (minimum 99%, Missing)",0.05,0.03,-0.435886,0,1,partial,99.7,0.2,0.2,"pituitary gland: 99.7 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136487,GH2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pituitary gland: 55.4114% (minimum 75%, Missing)",0.35,0.3,-0.195886,0,1,partial,99.7,0.2,0.2,"pituitary gland: 99.7 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136487,GH2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pituitary gland: 55.4114% (minimum 75%, Missing)",0.35,0.3,-0.195886,0,1,partial,99.7,0.2,0.2,"pituitary gland: 99.7 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136487,GH2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pituitary gland: 55.4114% (minimum 75%, Missing)",0.35,0.3,-0.195886,0,1,partial,99.7,0.2,0.2,"pituitary gland: 99.7 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136487,GH2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pituitary gland: 55.4114% (minimum 75%, Baseline (adaptation disabled))",0.348388,0.298388,-0.195886,0,1,partial,99.7,0.2,0.2,"pituitary gland: 99.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136487,GH2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0499159,0.03,0.00997897,0,2,partial,38.3,19.4,25.4,"smooth muscle: 38.3 nTPM (vital, limit 6); stomach: 19.4 nTPM (protected, limit 12); lung: 10.4 nTPM (vital, limit 6)",pituitary gland / cells in anterior : High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136488,CSH1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349916,0.3,0.249979,0,2,partial,38.3,19.4,25.4,"smooth muscle: 38.3 nTPM (vital, limit 6); stomach: 19.4 nTPM (protected, limit 12); lung: 10.4 nTPM (vital, limit 6)",pituitary gland / cells in anterior : High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136488,CSH1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349916,0.3,0.249979,0,2,partial,38.3,19.4,25.4,"smooth muscle: 38.3 nTPM (vital, limit 6); stomach: 19.4 nTPM (protected, limit 12); lung: 10.4 nTPM (vital, limit 6)",pituitary gland / cells in anterior : High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136488,CSH1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349916,0.3,0.249979,0,2,partial,38.3,19.4,25.4,"smooth muscle: 38.3 nTPM (vital, limit 6); stomach: 19.4 nTPM (protected, limit 12); lung: 10.4 nTPM (vital, limit 6)",pituitary gland / cells in anterior : High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136488,CSH1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347336,0.297964,0.245988,0,2,partial,38.3,19.4,25.4,"smooth muscle: 38.3 nTPM (vital, limit 1); spleen: 25.4 nTPM (manageable, limit 5); stomach: 19.4 nTPM (protected, limit 3); lung: 10.4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136488,CSH1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.9184% (minimum 99%, Missing); amygdala: 97.9167% (minimum 99%, Missing); basal ganglia: 94.0000% (minimum 99%, Missing); bone marrow: 63.5135% (minimum 99%, Missing); cerebral cortex: 97.9167% (minimum 99%, Missing); choroid plexus: 97.9167% (minimum 99%, Missing); colon: 87.0370% (minimum 97%, Missing); duodenum: 87.0370% (minimum 99%, Missing); esophagus: 78.3333% (minimum 97%, Missing); kidney: 97.9167% (minimum 99%, Missing); liver: 87.0370% (minimum 99%, Missing); lung: 94.0000% (minimum 99%, Missing); lymph node: 82.4561% (minimum 97%, Missing); pancreas: 95.9184% (minimum 99%, Missing); rectum: 87.0370% (minimum 97%, Missing); retina: 95.9184% (minimum 99%, Missing); salivary gland: 92.1569% (minimum 97%, Missing); skeletal muscle: 97.9167% (minimum 99%, Missing); skin: 87.0370% (minimum 95%, Missing); small intestine: 87.0370% (minimum 99%, Missing); smooth muscle: 97.9167% (minimum 98%, Approved); spleen: 92.1569% (minimum 95%, Missing); stomach: 92.1569% (minimum 97%, Missing); thymus: 56.6265% (minimum 95%, Missing); urinary bladder: 95.9184% (minimum 97%, Missing)",-0.383735,-0.186667,-0.354865,0,10,partial,2.7,1.3,3.6,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136492,BRIP1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.5135% (minimum 75%, Missing); thymus: 56.6265% (minimum 65%, Missing)",-0.0837349,0.0833333,-0.114865,0,10,partial,2.7,1.3,3.6,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136492,BRIP1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.5135% (minimum 75%, Missing); thymus: 56.6265% (minimum 65%, Missing)",-0.0837349,0.0833333,-0.114865,0,10,partial,2.7,1.3,3.6,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136492,BRIP1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.5135% (minimum 75%, Missing); thymus: 56.6265% (minimum 65%, Missing)",-0.0837349,0.0833333,-0.114865,0,10,partial,2.7,1.3,3.6,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136492,BRIP1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.5135% (minimum 75%, Baseline (adaptation disabled)); thymus: 56.6265% (minimum 65%, Baseline (adaptation disabled))",-0.0837349,0.0833333,-0.114865,0,10,partial,2.7,1.3,3.6,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136492,BRIP1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0000% (minimum 95%, Missing); adrenal gland: 53.5714% (minimum 99%, Missing); amygdala: 73.7705% (minimum 99%, Missing); basal ganglia: 72.1925% (minimum 99%, Missing); bone marrow: 36.9863% (minimum 99%, Missing); cerebellum: 88.2353% (minimum 99%, Uncertain); cerebral cortex: 53.7849% (minimum 99%, Missing); choroid plexus: 78.0347% (minimum 99%, Missing); colon: 57.2034% (minimum 97%, Missing); duodenum: 50.1859% (minimum 99%, Missing); esophagus: 60.2679% (minimum 97%, Missing); heart muscle: 53.7849% (minimum 99%, Uncertain); hippocampal formation: 72.1925% (minimum 99%, Missing); hypothalamus: 71.8085% (minimum 99%, Missing); kidney: 57.6923% (minimum 99%, Missing); liver: 47.2028% (minimum 99%, Missing); lung: 46.3918% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Uncertain); midbrain: 71.0526% (minimum 99%, Missing); pancreas: 59.2105% (minimum 99%, Uncertain); parathyroid gland: 71.0526% (minimum 97%, Missing); pituitary gland: 55.7851% (minimum 99%, Missing); rectum: 58.9520% (minimum 97%, Missing); retina: 59.2105% (minimum 99%, Missing); salivary gland: 65.2174% (minimum 97%, Missing); skeletal muscle: 55.7851% (minimum 99%, Missing); skin: 70.3125% (minimum 95%, Missing); small intestine: 49.4505% (minimum 99%, Missing); smooth muscle: 57.2034% (minimum 99%, Uncertain); spinal cord: 68.1818% (minimum 99%, Missing); spleen: 65.8537% (minimum 95%, Uncertain); stomach: 46.5517% (minimum 97%, Missing); thymus: 60.0000% (minimum 95%, Missing); thyroid gland: 55.1020% (minimum 95%, Missing); tongue: 39.5894% (minimum 97%, Missing); urinary bladder: 48.9130% (minimum 97%, Missing)",-0.41,-0.574106,-0.620137,0,1,partial,23,20.6,11.5,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 2); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 2); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 2); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 2); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 2); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); midbrain: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); hypothalamus: 5.3 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136603,SKIL,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0000% (minimum 65%, Missing); adrenal gland: 53.5714% (minimum 75%, Missing); amygdala: 73.7705% (minimum 75%, Missing); basal ganglia: 72.1925% (minimum 75%, Missing); bone marrow: 36.9863% (minimum 75%, Missing); cerebral cortex: 53.7849% (minimum 75%, Missing); colon: 57.2034% (minimum 70%, Missing); duodenum: 50.1859% (minimum 75%, Missing); esophagus: 60.2679% (minimum 70%, Missing); heart muscle: 53.7849% (minimum 75%, Uncertain); hippocampal formation: 72.1925% (minimum 75%, Missing); hypothalamus: 71.8085% (minimum 75%, Missing); kidney: 57.6923% (minimum 75%, Missing); liver: 47.2028% (minimum 75%, Missing); lung: 46.3918% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Uncertain); midbrain: 71.0526% (minimum 75%, Missing); pancreas: 59.2105% (minimum 75%, Uncertain); pituitary gland: 55.7851% (minimum 75%, Missing); rectum: 58.9520% (minimum 70%, Missing); retina: 59.2105% (minimum 75%, Missing); salivary gland: 65.2174% (minimum 70%, Missing); skeletal muscle: 55.7851% (minimum 75%, Missing); small intestine: 49.4505% (minimum 75%, Missing); smooth muscle: 57.2034% (minimum 75%, Uncertain); spinal cord: 68.1818% (minimum 75%, Missing); stomach: 46.5517% (minimum 70%, Missing); thymus: 60.0000% (minimum 65%, Missing); thyroid gland: 55.1020% (minimum 65%, Missing); tongue: 39.5894% (minimum 70%, Missing); urinary bladder: 48.9130% (minimum 70%, Missing)",-0.11,-0.304106,-0.380137,0,1,partial,23,20.6,11.5,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 2); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 2); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 2); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 2); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 2); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); midbrain: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); hypothalamus: 5.3 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136603,SKIL,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0000% (minimum 65%, Missing); adrenal gland: 53.5714% (minimum 75%, Missing); amygdala: 73.7705% (minimum 75%, Missing); basal ganglia: 72.1925% (minimum 75%, Missing); bone marrow: 36.9863% (minimum 75%, Missing); cerebral cortex: 53.7849% (minimum 75%, Missing); colon: 57.2034% (minimum 70%, Missing); duodenum: 50.1859% (minimum 75%, Missing); esophagus: 60.2679% (minimum 70%, Missing); heart muscle: 53.7849% (minimum 75%, Uncertain); hippocampal formation: 72.1925% (minimum 75%, Missing); hypothalamus: 71.8085% (minimum 75%, Missing); kidney: 57.6923% (minimum 75%, Missing); liver: 47.2028% (minimum 75%, Missing); lung: 46.3918% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Uncertain); midbrain: 71.0526% (minimum 75%, Missing); pancreas: 59.2105% (minimum 75%, Uncertain); pituitary gland: 55.7851% (minimum 75%, Missing); rectum: 58.9520% (minimum 70%, Missing); retina: 59.2105% (minimum 75%, Missing); salivary gland: 65.2174% (minimum 70%, Missing); skeletal muscle: 55.7851% (minimum 75%, Missing); small intestine: 49.4505% (minimum 75%, Missing); smooth muscle: 57.2034% (minimum 75%, Uncertain); spinal cord: 68.1818% (minimum 75%, Missing); stomach: 46.5517% (minimum 70%, Missing); thymus: 60.0000% (minimum 65%, Missing); thyroid gland: 55.1020% (minimum 65%, Missing); tongue: 39.5894% (minimum 70%, Missing); urinary bladder: 48.9130% (minimum 70%, Missing)",-0.11,-0.304106,-0.380137,0,1,partial,23,20.6,11.5,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 3); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 3); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 3); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 3); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 3); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); midbrain: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); hypothalamus: 5.3 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136603,SKIL,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0000% (minimum 65%, Missing); adrenal gland: 53.5714% (minimum 75%, Missing); amygdala: 73.7705% (minimum 75%, Missing); basal ganglia: 72.1925% (minimum 75%, Missing); bone marrow: 36.9863% (minimum 75%, Missing); cerebral cortex: 53.7849% (minimum 75%, Missing); colon: 57.2034% (minimum 70%, Missing); duodenum: 50.1859% (minimum 75%, Missing); esophagus: 60.2679% (minimum 70%, Missing); heart muscle: 53.7849% (minimum 75%, Uncertain); hippocampal formation: 72.1925% (minimum 75%, Missing); hypothalamus: 71.8085% (minimum 75%, Missing); kidney: 57.6923% (minimum 75%, Missing); liver: 47.2028% (minimum 75%, Missing); lung: 46.3918% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Uncertain); midbrain: 71.0526% (minimum 75%, Missing); pancreas: 59.2105% (minimum 75%, Uncertain); pituitary gland: 55.7851% (minimum 75%, Missing); rectum: 58.9520% (minimum 70%, Missing); retina: 59.2105% (minimum 75%, Missing); salivary gland: 65.2174% (minimum 70%, Missing); skeletal muscle: 55.7851% (minimum 75%, Missing); small intestine: 49.4505% (minimum 75%, Missing); smooth muscle: 57.2034% (minimum 75%, Uncertain); spinal cord: 68.1818% (minimum 75%, Missing); stomach: 46.5517% (minimum 70%, Missing); thymus: 60.0000% (minimum 65%, Missing); thyroid gland: 55.1020% (minimum 65%, Missing); tongue: 39.5894% (minimum 70%, Missing); urinary bladder: 48.9130% (minimum 70%, Missing)",-0.11,-0.304106,-0.380137,0,1,partial,23,20.6,11.5,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 3); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 3); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 3); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 3); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 3); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); midbrain: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); hypothalamus: 5.3 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136603,SKIL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 53.5714% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.7705% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 72.1925% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 36.9863% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.7849% (minimum 75%, Baseline (adaptation disabled)); colon: 57.2034% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.1859% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.2679% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 53.7849% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.1925% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.8085% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.6923% (minimum 75%, Baseline (adaptation disabled)); liver: 47.2028% (minimum 75%, Baseline (adaptation disabled)); lung: 46.3918% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); midbrain: 71.0526% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.2105% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 55.7851% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.9520% (minimum 70%, Baseline (adaptation disabled)); retina: 59.2105% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.2174% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.7851% (minimum 75%, Baseline (adaptation disabled)); small intestine: 49.4505% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.2034% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.1818% (minimum 75%, Baseline (adaptation disabled)); stomach: 46.5517% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.1020% (minimum 65%, Baseline (adaptation disabled)); tongue: 39.5894% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 48.9130% (minimum 70%, Baseline (adaptation disabled))",-0.11,-0.304106,-0.380137,0,1,partial,23,20.6,11.5,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 3); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 3); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 3); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 3); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 3); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); midbrain: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); hypothalamus: 5.3 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136603,SKIL,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.5047% (minimum 99%, Missing); basal ganglia: 97.2590% (minimum 99%, Missing); bone marrow: 93.2628% (minimum 95%, Enhanced); cerebellum: 91.0619% (minimum 95%, Enhanced); choroid plexus: 89.4005% (minimum 99%, Missing); colon: 95.4841% (minimum 97%, Missing); duodenum: 97.6590% (minimum 99%, Missing); hippocampal formation: 96.9840% (minimum 99%, Missing); hypothalamus: 96.5895% (minimum 99%, Missing); lung: 95.7803% (minimum 99%, Missing); midbrain: 97.2896% (minimum 99%, Missing); pituitary gland: 91.1965% (minimum 99%, Missing); rectum: 96.8623% (minimum 97%, Missing); retina: 97.0450% (minimum 99%, Missing); small intestine: 95.9590% (minimum 99%, Missing); spinal cord: 97.0450% (minimum 99%, Missing); thymus: 92.7584% (minimum 95%, Missing)",-0.0224159,-0.0151593,-0.0959948,0,13,partial,36.6,17.5,24.1,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 6); pituitary gland: 29.8 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); bone marrow: 22.3 nTPM (vital, limit 6); lymph node: 17.5 nTPM (protected, limit 12); urinary bladder: 16.1 nTPM (protected, limit 12); liver: 16 nTPM (vital, limit 6); colon: 14.6 nTPM (protected, limit 2); smooth muscle: 13.8 nTPM (vital, limit 6); kidney: 13.7 nTPM (vital, limit 6); lung: 13.6 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 12); small intestine: 13 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 6); pancreas: 11.5 nTPM (vital, limit 6); cerebral cortex: 11.1 nTPM (vital, limit 6); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 2); adrenal gland: 9.7 nTPM (vital, limit 6); hippocampal formation: 9.6 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 6); duodenum: 7.4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),85,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136811,ODF2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277584,0.254841,0.144005,0,13,partial,36.6,17.5,24.1,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 6); pituitary gland: 29.8 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); bone marrow: 22.3 nTPM (vital, limit 6); lymph node: 17.5 nTPM (protected, limit 12); urinary bladder: 16.1 nTPM (protected, limit 12); liver: 16 nTPM (vital, limit 6); colon: 14.6 nTPM (protected, limit 2); smooth muscle: 13.8 nTPM (vital, limit 6); kidney: 13.7 nTPM (vital, limit 6); lung: 13.6 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 12); small intestine: 13 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 6); pancreas: 11.5 nTPM (vital, limit 6); cerebral cortex: 11.1 nTPM (vital, limit 6); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 2); adrenal gland: 9.7 nTPM (vital, limit 6); hippocampal formation: 9.6 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 6); duodenum: 7.4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),85,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136811,ODF2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277584,0.254841,0.144005,0,13,partial,36.6,17.5,24.1,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 6); pituitary gland: 29.8 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); bone marrow: 22.3 nTPM (vital, limit 6); lymph node: 17.5 nTPM (protected, limit 12); urinary bladder: 16.1 nTPM (protected, limit 12); liver: 16 nTPM (vital, limit 6); colon: 14.6 nTPM (protected, limit 3); smooth muscle: 13.8 nTPM (vital, limit 6); kidney: 13.7 nTPM (vital, limit 6); lung: 13.6 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 12); small intestine: 13 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 6); pancreas: 11.5 nTPM (vital, limit 6); cerebral cortex: 11.1 nTPM (vital, limit 6); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 3); adrenal gland: 9.7 nTPM (vital, limit 6); hippocampal formation: 9.6 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 6); duodenum: 7.4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),85,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136811,ODF2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277584,0.254841,0.144005,0,13,partial,36.6,17.5,24.1,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 6); pituitary gland: 29.8 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); bone marrow: 22.3 nTPM (vital, limit 6); lymph node: 17.5 nTPM (protected, limit 12); urinary bladder: 16.1 nTPM (protected, limit 12); liver: 16 nTPM (vital, limit 6); colon: 14.6 nTPM (protected, limit 3); smooth muscle: 13.8 nTPM (vital, limit 6); kidney: 13.7 nTPM (vital, limit 6); lung: 13.6 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 12); small intestine: 13 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 6); pancreas: 11.5 nTPM (vital, limit 6); cerebral cortex: 11.1 nTPM (vital, limit 6); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 3); adrenal gland: 9.7 nTPM (vital, limit 6); hippocampal formation: 9.6 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 6); duodenum: 7.4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),85,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136811,ODF2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277584,0.246352,0.144005,0,13,partial,36.6,17.5,24.1,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pituitary gland: 29.8 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); bone marrow: 22.3 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 3); spleen: 17.2 nTPM (manageable, limit 5); urinary bladder: 16.1 nTPM (protected, limit 3); liver: 16 nTPM (vital, limit 1); colon: 14.6 nTPM (protected, limit 3); smooth muscle: 13.8 nTPM (vital, limit 1); kidney: 13.7 nTPM (vital, limit 1); lung: 13.6 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 3); skin: 12.7 nTPM (manageable, limit 5); heart muscle: 12.5 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 11.8 nTPM (protected, limit 3); esophagus: 11.5 nTPM (protected, limit 3); pancreas: 11.5 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 3); adrenal gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 3); spinal cord: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),85,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136811,ODF2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 81.2500% (minimum 95%, Missing); adrenal gland: 79.2683% (minimum 99%, Missing); amygdala: 78.3133% (minimum 99%, Missing); basal ganglia: 75.5814% (minimum 99%, Missing); bone marrow: 97.0149% (minimum 99%, Missing); cerebellum: 60.7477% (minimum 99%, Missing); cerebral cortex: 65.0000% (minimum 99%, Missing); choroid plexus: 85.5263% (minimum 99%, Missing); colon: 80.2469% (minimum 97%, Missing); duodenum: 90.2778% (minimum 99%, Missing); esophagus: 84.4156% (minimum 97%, Missing); heart muscle: 81.2500% (minimum 99%, Missing); hippocampal formation: 78.3133% (minimum 99%, Missing); hypothalamus: 75.5814% (minimum 99%, Missing); kidney: 74.7126% (minimum 99%, Missing); liver: 91.5493% (minimum 99%, Missing); lung: 84.4156% (minimum 99%, Missing); lymph node: 84.4156% (minimum 97%, Missing); midbrain: 79.2683% (minimum 99%, Missing); pancreas: 84.4156% (minimum 99%, Missing); parathyroid gland: 69.8925% (minimum 97%, Missing); pituitary gland: 63.7255% (minimum 99%, Missing); rectum: 86.6667% (minimum 97%, Missing); retina: 51.5873% (minimum 99%, Missing); salivary gland: 89.0411% (minimum 97%, Missing); skeletal muscle: 83.3333% (minimum 99%, Missing); skin: 84.4156% (minimum 95%, Missing); small intestine: 86.6667% (minimum 99%, Missing); smooth muscle: 73.0337% (minimum 99%, Missing); spinal cord: 73.0337% (minimum 99%, Missing); spleen: 76.4706% (minimum 95%, Missing); stomach: 84.4156% (minimum 97%, Missing); thymus: 85.5263% (minimum 95%, Missing); thyroid gland: 69.8925% (minimum 95%, Missing); tongue: 77.3810% (minimum 97%, Missing); urinary bladder: 79.2683% (minimum 97%, Missing)",-0.251075,-0.271075,-0.474127,0,80,unavailable,6.1,2.8,2.8,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136866,ZFP37,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 60.7477% (minimum 75%, Missing); cerebral cortex: 65.0000% (minimum 75%, Missing); kidney: 74.7126% (minimum 75%, Missing); parathyroid gland: 69.8925% (minimum 70%, Missing); pituitary gland: 63.7255% (minimum 75%, Missing); retina: 51.5873% (minimum 75%, Missing); smooth muscle: 73.0337% (minimum 75%, Missing); spinal cord: 73.0337% (minimum 75%, Missing)",0.0489247,-0.00107527,-0.234127,0,80,unavailable,6.1,2.8,2.8,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136866,ZFP37,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 60.7477% (minimum 75%, Missing); cerebral cortex: 65.0000% (minimum 75%, Missing); kidney: 74.7126% (minimum 75%, Missing); parathyroid gland: 69.8925% (minimum 70%, Missing); pituitary gland: 63.7255% (minimum 75%, Missing); retina: 51.5873% (minimum 75%, Missing); smooth muscle: 73.0337% (minimum 75%, Missing); spinal cord: 73.0337% (minimum 75%, Missing)",0.0489247,-0.00107527,-0.234127,0,80,unavailable,6.1,2.8,2.8,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136866,ZFP37,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 60.7477% (minimum 75%, Missing); cerebral cortex: 65.0000% (minimum 75%, Missing); kidney: 74.7126% (minimum 75%, Missing); parathyroid gland: 69.8925% (minimum 70%, Missing); pituitary gland: 63.7255% (minimum 75%, Missing); retina: 51.5873% (minimum 75%, Missing); smooth muscle: 73.0337% (minimum 75%, Missing); spinal cord: 73.0337% (minimum 75%, Missing)",0.0489247,-0.00107527,-0.234127,0,80,unavailable,6.1,2.8,2.8,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136866,ZFP37,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 60.7477% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.7126% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.8925% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.7255% (minimum 75%, Baseline (adaptation disabled)); retina: 51.5873% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.0337% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.0337% (minimum 75%, Baseline (adaptation disabled))",0.0489247,-0.00107527,-0.234127,0,80,unavailable,6.1,2.8,2.8,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136866,ZFP37,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 16.7749% (minimum 99%, Missing); retina: 98.7928% (minimum 99%, Missing); thymus: 79.7078% (minimum 95%, Missing)",-0.152922,0.0279675,-0.822251,0,2,partial,243.6,1.5,12.5,"bone marrow: 243.6 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136929,HEMGN,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 16.7749% (minimum 75%, Missing)",0.147078,0.297967,-0.582251,0,2,partial,243.6,1.5,12.5,"bone marrow: 243.6 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136929,HEMGN,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 16.7749% (minimum 75%, Missing)",0.147078,0.297967,-0.582251,0,2,partial,243.6,1.5,12.5,"bone marrow: 243.6 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136929,HEMGN,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 16.7749% (minimum 75%, Missing)",0.147078,0.297967,-0.582251,0,2,partial,243.6,1.5,12.5,"bone marrow: 243.6 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136929,HEMGN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 16.7749% (minimum 75%, Baseline (adaptation disabled))",0.147078,0.270356,-0.582251,0,2,partial,243.6,1.5,12.5,"bone marrow: 243.6 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136929,HEMGN,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.9565% (minimum 95%, Missing); bone marrow: 97.5610% (minimum 99%, Missing); choroid plexus: 97.5610% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); heart muscle: 67.7966% (minimum 99%, Missing); hypothalamus: 90.9091% (minimum 99%, Missing); kidney: 53.3333% (minimum 99%, Missing); lung: 97.5610% (minimum 99%, Missing); midbrain: 52.6316% (minimum 99%, Missing); pancreas: 95.2381% (minimum 99%, Missing); parathyroid gland: 80.0000% (minimum 97%, Missing); pituitary gland: 95.2381% (minimum 99%, Missing); salivary gland: 18.1818% (minimum 97%, Missing); skin: 66.6667% (minimum 95%, Missing); small intestine: 97.5610% (minimum 99%, Missing); spinal cord: 75.4717% (minimum 99%, Missing); thyroid gland: 90.9091% (minimum 95%, Missing)",-0.283333,-0.788182,-0.463684,0,80,unavailable,3.6,18,2,"salivary gland: 18 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136944,LMX1B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 67.7966% (minimum 75%, Missing); kidney: 53.3333% (minimum 75%, Missing); midbrain: 52.6316% (minimum 75%, Missing); salivary gland: 18.1818% (minimum 70%, Missing)",0.0166667,-0.518182,-0.223684,0,80,unavailable,3.6,18,2,"salivary gland: 18 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136944,LMX1B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 67.7966% (minimum 75%, Missing); kidney: 53.3333% (minimum 75%, Missing); midbrain: 52.6316% (minimum 75%, Missing); salivary gland: 18.1818% (minimum 70%, Missing)",0.0166667,-0.518182,-0.223684,0,80,unavailable,3.6,18,2,"salivary gland: 18 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136944,LMX1B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 67.7966% (minimum 75%, Missing); kidney: 53.3333% (minimum 75%, Missing); midbrain: 52.6316% (minimum 75%, Missing); salivary gland: 18.1818% (minimum 70%, Missing)",0.0166667,-0.518182,-0.223684,0,80,unavailable,3.6,18,2,"salivary gland: 18 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136944,LMX1B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 67.7966% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.3333% (minimum 75%, Baseline (adaptation disabled)); midbrain: 52.6316% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 18.1818% (minimum 70%, Baseline (adaptation disabled))",0.0166667,-0.518182,-0.223684,0,80,unavailable,3.6,18,2,"salivary gland: 18 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000136944,LMX1B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.8636% (minimum 99%, Missing)",0.05,0.03,-0.00136364,0,2,partial,0.3,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137090,DMRT1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.238636,0,2,partial,0.3,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137090,DMRT1,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.238636,0,2,partial,0.3,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137090,DMRT1,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.238636,0,2,partial,0.3,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137090,DMRT1,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342395,0.3,0.238636,0,2,partial,0.3,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137090,DMRT1,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 93.3544% (minimum 95%, Missing)",-0.0164557,0.0266216,0.00662162,0,3,partial,0.4,0.4,2.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137225,CAPN11,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.283544,0.296622,0.246622,0,3,partial,0.4,0.4,2.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137225,CAPN11,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.283544,0.296622,0.246622,0,3,partial,0.4,0.4,2.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137225,CAPN11,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.283544,0.296622,0.246622,0,3,partial,0.4,0.4,2.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137225,CAPN11,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.283544,0.286622,0.236622,0,3,partial,0.4,0.4,2.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137225,CAPN11,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 93.7500% (minimum 95%, Enhanced); retina: 98.4848% (minimum 99%, Missing); skeletal muscle: 85.1528% (minimum 95%, Enhanced)",0.05,0.03,-0.0984716,0,5,partial,3.4,0.2,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137270,GCM1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.234848,0,5,partial,3.4,0.2,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137270,GCM1,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.234848,0,5,partial,3.4,0.2,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137270,GCM1,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.234848,0,5,partial,3.4,0.2,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137270,GCM1,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329899,0.289848,0.101528,0,5,partial,3.4,0.2,0.4,"skeletal muscle: 3.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137270,GCM1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.0070% (minimum 95%, Missing); adrenal gland: 88.0795% (minimum 99%, Missing); amygdala: 75.5682% (minimum 99%, Missing); basal ganglia: 80.6061% (minimum 99%, Missing); bone marrow: 97.7941% (minimum 99%, Missing); cerebellum: 90.4762% (minimum 99%, Missing); cerebral cortex: 80.1205% (minimum 99%, Missing); choroid plexus: 84.1772% (minimum 99%, Missing); colon: 95.0000% (minimum 97%, Missing); duodenum: 89.8649% (minimum 99%, Missing); esophagus: 95.6835% (minimum 97%, Missing); heart muscle: 95.6835% (minimum 99%, Missing); hippocampal formation: 78.2353% (minimum 99%, Missing); hypothalamus: 75.5682% (minimum 99%, Missing); kidney: 75.5682% (minimum 99%, Missing); liver: 95.0000% (minimum 99%, Missing); lung: 93.0070% (minimum 99%, Missing); midbrain: 77.3256% (minimum 99%, Missing); pancreas: 85.8065% (minimum 99%, Missing); pituitary gland: 87.5000% (minimum 99%, Missing); retina: 95.0000% (minimum 99%, Missing); salivary gland: 95.0000% (minimum 97%, Missing); skeletal muscle: 96.3768% (minimum 99%, Missing); skin: 91.0959% (minimum 95%, Missing); small intestine: 95.0000% (minimum 99%, Missing); smooth muscle: 97.7941% (minimum 99%, Missing); spinal cord: 79.1667% (minimum 99%, Missing); stomach: 89.8649% (minimum 97%, Missing); thyroid gland: 93.6620% (minimum 95%, Missing); urinary bladder: 95.6835% (minimum 97%, Missing)",-0.0390411,-0.0713514,-0.234318,0,80,unavailable,4.3,1.5,1.3,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137434,C6orf52,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.260959,0.198649,0.00568182,0,80,unavailable,4.3,1.5,1.3,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137434,C6orf52,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.260959,0.198649,0.00568182,0,80,unavailable,4.3,1.5,1.3,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137434,C6orf52,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.260959,0.198649,0.00568182,0,80,unavailable,4.3,1.5,1.3,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137434,C6orf52,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.260959,0.198649,0.00568182,0,80,unavailable,4.3,1.5,1.3,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137434,C6orf52,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.7270% (minimum 99%, Missing); basal ganglia: 98.0337% (minimum 99%, Missing); choroid plexus: 92.2061% (minimum 99%, Missing); hippocampal formation: 98.1716% (minimum 99%, Missing); hypothalamus: 97.8962% (minimum 99%, Missing); lung: 97.3501% (minimum 99%, Uncertain)",0.0485694,0.0214773,-0.0679392,0,0,routine_complete,5.9,0.6,0.1,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137473,TTC29,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.348569,0.291477,0.172061,0,0,routine_complete,5.9,0.6,0.1,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137473,TTC29,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.348569,0.291477,0.172061,0,0,routine_complete,5.9,0.6,0.1,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137473,TTC29,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.348569,0.291477,0.172061,0,0,routine_complete,5.9,0.6,0.1,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137473,TTC29,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.348569,0.291477,0.172061,0,0,routine_complete,5.9,0.6,0.1,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137473,TTC29,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 85.7143% (minimum 99%, Missing)",0.05,0.03,-0.132857,0,80,unavailable,0.1,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137674,MMP20,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.107143,0,80,unavailable,0.1,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137674,MMP20,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.107143,0,80,unavailable,0.1,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137674,MMP20,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.107143,0,80,unavailable,0.1,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137674,MMP20,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.107143,0,80,unavailable,0.1,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137674,MMP20,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 89.8773% (minimum 95%, Enhanced); amygdala: 93.9103% (minimum 99%, Missing); basal ganglia: 90.9938% (minimum 99%, Missing); choroid plexus: 55.3875% (minimum 99%, Missing); hippocampal formation: 91.8495% (minimum 99%, Missing); hypothalamus: 89.6024% (minimum 99%, Missing); kidney: 94.8220% (minimum 95%, Enhanced); lung: 91.2773% (minimum 95%, Enhanced); midbrain: 95.1299% (minimum 99%, Missing); pituitary gland: 88.2530% (minimum 99%, Missing); retina: 95.7516% (minimum 99%, Missing); smooth muscle: 91.2773% (minimum 95%, Enhanced); spinal cord: 95.4397% (minimum 99%, Missing)",0.0299331,0.03,-0.436125,0,3,partial,23.6,2.9,3.5,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137691,CFAP300,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 55.3875% (minimum 75%, Missing)",0.329933,0.3,-0.196125,0,3,partial,23.6,2.9,3.5,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137691,CFAP300,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 55.3875% (minimum 75%, Missing)",0.329933,0.3,-0.196125,0,3,partial,23.6,2.9,3.5,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137691,CFAP300,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 55.3875% (minimum 75%, Missing)",0.329933,0.3,-0.196125,0,3,partial,23.6,2.9,3.5,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137691,CFAP300,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 55.3875% (minimum 75%, Baseline (adaptation disabled))",0.243293,0.209938,-0.196125,0,3,partial,23.6,2.9,3.5,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137691,CFAP300,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 83.6502% (minimum 99%, Missing); lung: 98.2143% (minimum 99%, Missing)",0.0454751,0.03,-0.153498,0,80,unavailable,4.3,0,0.1,"choroid plexus: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137707,BTG4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345475,0.3,0.0865019,0,80,unavailable,4.3,0,0.1,"choroid plexus: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137707,BTG4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345475,0.3,0.0865019,0,80,unavailable,4.3,0,0.1,"choroid plexus: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137707,BTG4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345475,0.3,0.0865019,0,80,unavailable,4.3,0,0.1,"choroid plexus: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137707,BTG4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345475,0.3,0.0865019,0,80,unavailable,4.3,0,0.1,"choroid plexus: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137707,BTG4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.1031% (minimum 90%, Approved); adrenal gland: 73.9130% (minimum 99%, Missing); amygdala: 86.0759% (minimum 99%, Missing); basal ganglia: 86.0759% (minimum 99%, Missing); bone marrow: 50.2463% (minimum 99%, Missing); cerebellum: 69.3878% (minimum 98%, Approved); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 86.4407% (minimum 99%, Missing); colon: 66.0194% (minimum 97%, Missing); duodenum: 67.7741% (minimum 99%, Missing); esophagus: 62.7692% (minimum 97%, Missing); heart muscle: 68.9189% (minimum 99%, Missing); hippocampal formation: 85.7143% (minimum 99%, Missing); hypothalamus: 86.8085% (minimum 99%, Missing); kidney: 66.2338% (minimum 99%, Missing); liver: 67.1053% (minimum 99%, Missing); lung: 66.8852% (minimum 99%, Missing); lymph node: 51.9084% (minimum 97%, Missing); midbrain: 87.9310% (minimum 99%, Missing); pancreas: 64.5570% (minimum 99%, Missing); parathyroid gland: 65.5949% (minimum 97%, Missing); pituitary gland: 83.9506% (minimum 99%, Missing); rectum: 65.1757% (minimum 97%, Missing); retina: 58.1197% (minimum 99%, Missing); salivary gland: 69.6246% (minimum 97%, Missing); skeletal muscle: 79.6875% (minimum 99%, Missing); skin: 72.0848% (minimum 95%, Missing); small intestine: 62.1951% (minimum 99%, Missing); smooth muscle: 60.3550% (minimum 98%, Approved); spinal cord: 84.6473% (minimum 99%, Missing); spleen: 61.2613% (minimum 95%, Missing); stomach: 68.2274% (minimum 97%, Missing); thymus: 45.3333% (minimum 95%, Missing); thyroid gland: 58.2857% (minimum 90%, Approved); tongue: 69.1525% (minimum 97%, Missing); urinary bladder: 63.3540% (minimum 97%, Missing)",-0.496667,-0.450916,-0.487537,0,5,partial,20.2,18.9,24.6,"thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 2); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (manageable, limit 10); smooth muscle: 13.4 nTPM (vital, limit 2); spleen: 12.9 nTPM (manageable, limit 5); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 2); urinary bladder: 11.8 nTPM (protected, limit 2); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.7 nTPM (protected, limit 2); colon: 10.5 nTPM (protected, limit 2); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 2); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 2); cerebellum: 9 nTPM (vital, limit 2); salivary gland: 8.9 nTPM (protected, limit 2); skin: 7.9 nTPM (manageable, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137770,CTDSPL2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.9130% (minimum 75%, Missing); bone marrow: 50.2463% (minimum 75%, Missing); cerebellum: 69.3878% (minimum 70%, Approved); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 66.0194% (minimum 70%, Missing); duodenum: 67.7741% (minimum 75%, Missing); esophagus: 62.7692% (minimum 70%, Missing); heart muscle: 68.9189% (minimum 75%, Missing); kidney: 66.2338% (minimum 75%, Missing); liver: 67.1053% (minimum 75%, Missing); lung: 66.8852% (minimum 75%, Missing); lymph node: 51.9084% (minimum 70%, Missing); pancreas: 64.5570% (minimum 75%, Missing); parathyroid gland: 65.5949% (minimum 70%, Missing); rectum: 65.1757% (minimum 70%, Missing); retina: 58.1197% (minimum 75%, Missing); salivary gland: 69.6246% (minimum 70%, Missing); small intestine: 62.1951% (minimum 75%, Missing); smooth muscle: 60.3550% (minimum 70%, Approved); spleen: 61.2613% (minimum 65%, Missing); stomach: 68.2274% (minimum 70%, Missing); thymus: 45.3333% (minimum 65%, Missing); thyroid gland: 58.2857% (minimum 60%, Approved); tongue: 69.1525% (minimum 70%, Missing); urinary bladder: 63.3540% (minimum 70%, Missing)",-0.196667,-0.180916,-0.247537,0,5,partial,20.2,18.9,24.6,"thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 2); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (manageable, limit 10); smooth muscle: 13.4 nTPM (vital, limit 2); spleen: 12.9 nTPM (manageable, limit 5); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 2); urinary bladder: 11.8 nTPM (protected, limit 2); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.7 nTPM (protected, limit 2); colon: 10.5 nTPM (protected, limit 2); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 2); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 2); cerebellum: 9 nTPM (vital, limit 2); salivary gland: 8.9 nTPM (protected, limit 2); skin: 7.9 nTPM (manageable, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137770,CTDSPL2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.9130% (minimum 75%, Missing); bone marrow: 50.2463% (minimum 75%, Missing); cerebellum: 69.3878% (minimum 70%, Approved); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 66.0194% (minimum 70%, Missing); duodenum: 67.7741% (minimum 75%, Missing); esophagus: 62.7692% (minimum 70%, Missing); heart muscle: 68.9189% (minimum 75%, Missing); kidney: 66.2338% (minimum 75%, Missing); liver: 67.1053% (minimum 75%, Missing); lung: 66.8852% (minimum 75%, Missing); lymph node: 51.9084% (minimum 70%, Missing); pancreas: 64.5570% (minimum 75%, Missing); parathyroid gland: 65.5949% (minimum 70%, Missing); rectum: 65.1757% (minimum 70%, Missing); retina: 58.1197% (minimum 75%, Missing); salivary gland: 69.6246% (minimum 70%, Missing); small intestine: 62.1951% (minimum 75%, Missing); smooth muscle: 60.3550% (minimum 70%, Approved); spleen: 61.2613% (minimum 65%, Missing); stomach: 68.2274% (minimum 70%, Missing); thymus: 45.3333% (minimum 65%, Missing); thyroid gland: 58.2857% (minimum 60%, Approved); tongue: 69.1525% (minimum 70%, Missing); urinary bladder: 63.3540% (minimum 70%, Missing)",-0.196667,-0.180916,-0.247537,0,5,partial,20.2,18.9,24.6,"thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 3); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (manageable, limit 10); smooth muscle: 13.4 nTPM (vital, limit 2); spleen: 12.9 nTPM (manageable, limit 5); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 3); urinary bladder: 11.8 nTPM (protected, limit 3); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.7 nTPM (protected, limit 3); colon: 10.5 nTPM (protected, limit 3); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 3); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 3); cerebellum: 9 nTPM (vital, limit 2); salivary gland: 8.9 nTPM (protected, limit 3); skin: 7.9 nTPM (manageable, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137770,CTDSPL2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.9130% (minimum 75%, Missing); bone marrow: 50.2463% (minimum 75%, Missing); cerebellum: 69.3878% (minimum 70%, Approved); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 66.0194% (minimum 70%, Missing); duodenum: 67.7741% (minimum 75%, Missing); esophagus: 62.7692% (minimum 70%, Missing); heart muscle: 68.9189% (minimum 75%, Missing); kidney: 66.2338% (minimum 75%, Missing); liver: 67.1053% (minimum 75%, Missing); lung: 66.8852% (minimum 75%, Missing); lymph node: 51.9084% (minimum 70%, Missing); pancreas: 64.5570% (minimum 75%, Missing); parathyroid gland: 65.5949% (minimum 70%, Missing); rectum: 65.1757% (minimum 70%, Missing); retina: 58.1197% (minimum 75%, Missing); salivary gland: 69.6246% (minimum 70%, Missing); small intestine: 62.1951% (minimum 75%, Missing); smooth muscle: 60.3550% (minimum 70%, Approved); spleen: 61.2613% (minimum 65%, Missing); stomach: 68.2274% (minimum 70%, Missing); thymus: 45.3333% (minimum 65%, Missing); thyroid gland: 58.2857% (minimum 60%, Approved); tongue: 69.1525% (minimum 70%, Missing); urinary bladder: 63.3540% (minimum 70%, Missing)",-0.196667,-0.180916,-0.247537,0,5,partial,20.2,18.9,24.6,"thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 3); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (manageable, limit 10); smooth muscle: 13.4 nTPM (vital, limit 2); spleen: 12.9 nTPM (manageable, limit 5); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 3); urinary bladder: 11.8 nTPM (protected, limit 3); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.7 nTPM (protected, limit 3); colon: 10.5 nTPM (protected, limit 3); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 3); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 3); cerebellum: 9 nTPM (vital, limit 2); salivary gland: 8.9 nTPM (protected, limit 3); skin: 7.9 nTPM (manageable, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137770,CTDSPL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.9130% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 50.2463% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 69.3878% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); colon: 66.0194% (minimum 70%, Baseline (adaptation disabled)); duodenum: 67.7741% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.7692% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.9189% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.2338% (minimum 75%, Baseline (adaptation disabled)); liver: 67.1053% (minimum 75%, Baseline (adaptation disabled)); lung: 66.8852% (minimum 75%, Baseline (adaptation disabled)); lymph node: 51.9084% (minimum 70%, Baseline (adaptation disabled)); pancreas: 64.5570% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.5949% (minimum 70%, Baseline (adaptation disabled)); rectum: 65.1757% (minimum 70%, Baseline (adaptation disabled)); retina: 58.1197% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 69.6246% (minimum 70%, Baseline (adaptation disabled)); small intestine: 62.1951% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.3550% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.2613% (minimum 65%, Baseline (adaptation disabled)); stomach: 68.2274% (minimum 70%, Baseline (adaptation disabled)); thymus: 45.3333% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.2857% (minimum 65%, Baseline (adaptation disabled)); tongue: 69.1525% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.3540% (minimum 70%, Baseline (adaptation disabled))",-0.196667,-0.180916,-0.247537,0,5,partial,20.2,18.9,24.6,"thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 3); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (manageable, limit 5); smooth muscle: 13.4 nTPM (vital, limit 1); spleen: 12.9 nTPM (manageable, limit 5); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 3); urinary bladder: 11.8 nTPM (protected, limit 3); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.7 nTPM (protected, limit 3); colon: 10.5 nTPM (protected, limit 3); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 3); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 3); cerebellum: 9 nTPM (vital, limit 1); salivary gland: 8.9 nTPM (protected, limit 3); adipose tissue: 8.7 nTPM (manageable, limit 5); skin: 7.9 nTPM (manageable, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137770,CTDSPL2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 76.2791% (minimum 99%, Missing); colon: 93.1818% (minimum 97%, Missing); duodenum: 91.6201% (minimum 99%, Missing); esophagus: 94.7977% (minimum 97%, Missing); lymph node: 82.4121% (minimum 97%, Missing); rectum: 92.6554% (minimum 97%, Missing); retina: 98.7952% (minimum 99%, Missing); small intestine: 91.1111% (minimum 99%, Missing); thymus: 69.4915% (minimum 95%, Missing)",-0.255085,-0.145879,-0.227209,0,2,partial,5.1,3.5,7.2,"thymus: 7.2 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137812,KNL1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0449153,0.124121,0.0127907,0,2,partial,5.1,3.5,7.2,"thymus: 7.2 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137812,KNL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0449153,0.124121,0.0127907,0,2,partial,5.1,3.5,7.2,"thymus: 7.2 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137812,KNL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0449153,0.124121,0.0127907,0,2,partial,5.1,3.5,7.2,"thymus: 7.2 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137812,KNL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0449153,0.124121,0.0127907,0,2,partial,5.1,3.5,7.2,"thymus: 7.2 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137812,KNL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.2540% (minimum 98%, Approved); amygdala: 43.5443% (minimum 99%, Missing); basal ganglia: 43.1078% (minimum 99%, Missing); bone marrow: 95.0276% (minimum 98%, Approved); cerebellum: 46.2366% (minimum 98%, Approved); cerebral cortex: 35.1020% (minimum 99%, Missing); choroid plexus: 88.2051% (minimum 99%, Missing); colon: 93.4783% (minimum 95%, Approved); duodenum: 92.4731% (minimum 98%, Approved); esophagus: 40.8551% (minimum 97%, Missing); heart muscle: 68.2540% (minimum 99%, Missing); hippocampal formation: 49.4253% (minimum 99%, Missing); hypothalamus: 67.9842% (minimum 99%, Missing); kidney: 78.8991% (minimum 99%, Missing); lung: 87.3096% (minimum 98%, Approved); midbrain: 83.9024% (minimum 99%, Missing); pancreas: 68.8000% (minimum 98%, Approved); parathyroid gland: 69.0763% (minimum 95%, Approved); pituitary gland: 59.3103% (minimum 99%, Missing); rectum: 94.5055% (minimum 95%, Approved); retina: 95.5556% (minimum 99%, Missing); salivary gland: 74.1379% (minimum 95%, Approved); skeletal muscle: 80.0000% (minimum 98%, Approved); skin: 38.6517% (minimum 95%, Missing); small intestine: 92.4731% (minimum 98%, Approved); spinal cord: 91.0053% (minimum 99%, Missing); stomach: 81.9048% (minimum 95%, Approved); thyroid gland: 70.4918% (minimum 95%, Missing); tongue: 93.4783% (minimum 97%, Missing); urinary bladder: 83.4951% (minimum 95%, Approved)",-0.563483,-0.561449,-0.63898,0,1,partial,31.8,24.9,27.3,"cerebral cortex: 31.8 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 24.9 nTPM (protected, limit 2); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 2); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 2); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 2); parathyroid gland: 7.7 nTPM (protected, limit 4); thyroid gland: 7.2 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 2); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); thyroid gland / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137843,PAK6,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.2540% (minimum 70%, Approved); amygdala: 43.5443% (minimum 75%, Missing); basal ganglia: 43.1078% (minimum 75%, Missing); cerebellum: 46.2366% (minimum 70%, Approved); cerebral cortex: 35.1020% (minimum 75%, Missing); esophagus: 40.8551% (minimum 70%, Missing); heart muscle: 68.2540% (minimum 75%, Missing); hippocampal formation: 49.4253% (minimum 75%, Missing); hypothalamus: 67.9842% (minimum 75%, Missing); pancreas: 68.8000% (minimum 70%, Approved); pituitary gland: 59.3103% (minimum 75%, Missing); skin: 38.6517% (minimum 65%, Missing)",-0.263483,-0.291449,-0.39898,0,1,partial,31.8,24.9,27.3,"cerebral cortex: 31.8 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 24.9 nTPM (protected, limit 2); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 2); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 2); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 2); parathyroid gland: 7.7 nTPM (protected, limit 4); thyroid gland: 7.2 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 2); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); thyroid gland / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137843,PAK6,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.2540% (minimum 70%, Approved); amygdala: 43.5443% (minimum 75%, Missing); basal ganglia: 43.1078% (minimum 75%, Missing); cerebellum: 46.2366% (minimum 70%, Approved); cerebral cortex: 35.1020% (minimum 75%, Missing); esophagus: 40.8551% (minimum 70%, Missing); heart muscle: 68.2540% (minimum 75%, Missing); hippocampal formation: 49.4253% (minimum 75%, Missing); hypothalamus: 67.9842% (minimum 75%, Missing); pancreas: 68.8000% (minimum 70%, Approved); pituitary gland: 59.3103% (minimum 75%, Missing); skin: 38.6517% (minimum 65%, Missing)",-0.263483,-0.291449,-0.39898,0,1,partial,31.8,24.9,27.3,"cerebral cortex: 31.8 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 24.9 nTPM (protected, limit 3); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 2); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 2); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 2); parathyroid gland: 7.7 nTPM (protected, limit 4); thyroid gland: 7.2 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 2); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); thyroid gland / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137843,PAK6,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.2540% (minimum 70%, Approved); amygdala: 43.5443% (minimum 75%, Missing); basal ganglia: 43.1078% (minimum 75%, Missing); cerebellum: 46.2366% (minimum 70%, Approved); cerebral cortex: 35.1020% (minimum 75%, Missing); esophagus: 40.8551% (minimum 70%, Missing); heart muscle: 68.2540% (minimum 75%, Missing); hippocampal formation: 49.4253% (minimum 75%, Missing); hypothalamus: 67.9842% (minimum 75%, Missing); pancreas: 68.8000% (minimum 70%, Approved); pituitary gland: 59.3103% (minimum 75%, Missing); skin: 38.6517% (minimum 65%, Missing)",-0.263483,-0.291449,-0.39898,0,1,partial,31.8,24.9,27.3,"cerebral cortex: 31.8 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 24.9 nTPM (protected, limit 3); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 2); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 2); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 2); parathyroid gland: 7.7 nTPM (protected, limit 4); thyroid gland: 7.2 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 2); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); thyroid gland / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137843,PAK6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.2540% (minimum 75%, Baseline (adaptation disabled)); amygdala: 43.5443% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 43.1078% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 46.2366% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 35.1020% (minimum 75%, Baseline (adaptation disabled)); esophagus: 40.8551% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.2540% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 49.4253% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.9842% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.8000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.0763% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 59.3103% (minimum 75%, Baseline (adaptation disabled)); skin: 38.6517% (minimum 65%, Baseline (adaptation disabled))",-0.263483,-0.291449,-0.39898,0,1,partial,31.8,24.9,27.3,"cerebral cortex: 31.8 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 24.9 nTPM (protected, limit 3); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 1); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 3); thyroid gland: 7.2 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 3); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); thyroid gland / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137843,PAK6,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.6286% (minimum 95%, Enhanced)",0.048343,0.0275166,-0.0137141,0,1,partial,8.2,3.3,8,"adrenal gland: 8.2 nTPM (vital, limit 6)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137869,CYP19A1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348343,0.297517,0.245045,0,1,partial,8.2,3.3,8,"adrenal gland: 8.2 nTPM (vital, limit 6)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137869,CYP19A1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348343,0.297517,0.245045,0,1,partial,8.2,3.3,8,"adrenal gland: 8.2 nTPM (vital, limit 6)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137869,CYP19A1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348343,0.297517,0.245045,0,1,partial,8.2,3.3,8,"adrenal gland: 8.2 nTPM (vital, limit 6)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137869,CYP19A1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.287743,0.273344,0.186286,0,1,partial,8.2,3.3,8,"adrenal gland: 8.2 nTPM (vital, limit 1); adipose tissue: 8 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137869,CYP19A1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0484351,0.0292169,3.0722e-05,0,6,partial,2.6,0.4,0.4,"bone marrow: 2.6 nTPM (vital, limit 2)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137948,BRDT,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348435,0.299217,0.247654,0,6,partial,2.6,0.4,0.4,"bone marrow: 2.6 nTPM (vital, limit 2)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137948,BRDT,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348435,0.299217,0.247654,0,6,partial,2.6,0.4,0.4,"bone marrow: 2.6 nTPM (vital, limit 2)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137948,BRDT,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348435,0.299217,0.247654,0,6,partial,2.6,0.4,0.4,"bone marrow: 2.6 nTPM (vital, limit 2)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137948,BRDT,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346875,0.296875,0.230031,0,6,partial,2.6,0.4,0.4,"bone marrow: 2.6 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137948,BRDT,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7368% (minimum 95%, Missing); adrenal gland: 88.5246% (minimum 99%, Missing); amygdala: 72.9730% (minimum 99%, Missing); basal ganglia: 85.7143% (minimum 99%, Missing); bone marrow: 96.4286% (minimum 99%, Missing); cerebellum: 96.4286% (minimum 99%, Missing); cerebral cortex: 62.7907% (minimum 99%, Missing); colon: 72.9730% (minimum 97%, Missing); duodenum: 81.8182% (minimum 99%, Missing); esophagus: 45.7627% (minimum 97%, Missing); heart muscle: 69.2308% (minimum 99%, Missing); hippocampal formation: 70.1299% (minimum 99%, Missing); hypothalamus: 69.2308% (minimum 99%, Missing); kidney: 73.9726% (minimum 99%, Missing); liver: 84.3750% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); lymph node: 91.5254% (minimum 97%, Missing); midbrain: 73.9726% (minimum 99%, Missing); pancreas: 76.0563% (minimum 99%, Missing); parathyroid gland: 60.0000% (minimum 97%, Missing); pituitary gland: 63.5294% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 69.2308% (minimum 99%, Missing); salivary gland: 79.4118% (minimum 97%, Missing); skeletal muscle: 78.2609% (minimum 99%, Missing); skin: 34.1772% (minimum 95%, Missing); small intestine: 80.5970% (minimum 99%, Missing); smooth muscle: 96.4286% (minimum 99%, Missing); spinal cord: 85.7143% (minimum 99%, Missing); spleen: 88.5246% (minimum 95%, Missing); stomach: 79.4118% (minimum 97%, Missing); thymus: 68.3544% (minimum 95%, Missing); thyroid gland: 88.5246% (minimum 95%, Missing); tongue: 78.2609% (minimum 97%, Missing); urinary bladder: 77.1429% (minimum 97%, Missing)",-0.608228,-0.512373,-0.362093,0,80,unavailable,3.2,6.4,10.4,"skin: 10.4 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137968,SLC44A5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.9730% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); esophagus: 45.7627% (minimum 70%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 70.1299% (minimum 75%, Missing); hypothalamus: 69.2308% (minimum 75%, Missing); kidney: 73.9726% (minimum 75%, Missing); midbrain: 73.9726% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); pituitary gland: 63.5294% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); skin: 34.1772% (minimum 65%, Missing)",-0.308228,-0.242373,-0.122093,0,80,unavailable,3.2,6.4,10.4,"skin: 10.4 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137968,SLC44A5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.9730% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); esophagus: 45.7627% (minimum 70%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 70.1299% (minimum 75%, Missing); hypothalamus: 69.2308% (minimum 75%, Missing); kidney: 73.9726% (minimum 75%, Missing); midbrain: 73.9726% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); pituitary gland: 63.5294% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); skin: 34.1772% (minimum 65%, Missing)",-0.308228,-0.242373,-0.122093,0,80,unavailable,3.2,6.4,10.4,"skin: 10.4 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137968,SLC44A5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.9730% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); esophagus: 45.7627% (minimum 70%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 70.1299% (minimum 75%, Missing); hypothalamus: 69.2308% (minimum 75%, Missing); kidney: 73.9726% (minimum 75%, Missing); midbrain: 73.9726% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); pituitary gland: 63.5294% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); skin: 34.1772% (minimum 65%, Missing)",-0.308228,-0.242373,-0.122093,0,80,unavailable,3.2,6.4,10.4,"skin: 10.4 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137968,SLC44A5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.9730% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.7907% (minimum 75%, Baseline (adaptation disabled)); esophagus: 45.7627% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.2308% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.1299% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.2308% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.9726% (minimum 75%, Baseline (adaptation disabled)); midbrain: 73.9726% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.5294% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 69.2308% (minimum 75%, Baseline (adaptation disabled)); skin: 34.1772% (minimum 65%, Baseline (adaptation disabled))",-0.308228,-0.242373,-0.122093,0,80,unavailable,3.2,6.4,10.4,"skin: 10.4 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137968,SLC44A5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.8571% (minimum 95%, Missing); adrenal gland: 98.4848% (minimum 99%, Missing); amygdala: 97.0149% (minimum 99%, Missing); basal ganglia: 86.6667% (minimum 99%, Missing); cerebellum: 98.4848% (minimum 99%, Missing); cerebral cortex: 95.5882% (minimum 99%, Missing); choroid plexus: 98.4848% (minimum 99%, Missing); colon: 94.2029% (minimum 97%, Missing); hippocampal formation: 95.5882% (minimum 99%, Missing); hypothalamus: 92.8571% (minimum 99%, Missing); liver: 95.5882% (minimum 99%, Missing); lung: 73.8636% (minimum 99%, Missing); lymph node: 90.2778% (minimum 97%, Missing); midbrain: 95.5882% (minimum 99%, Missing); pancreas: 90.2778% (minimum 99%, Missing); pituitary gland: 95.5882% (minimum 99%, Missing); rectum: 92.8571% (minimum 97%, Missing); salivary gland: 3.7835% (minimum 97%, Missing); skeletal muscle: 81.2500% (minimum 99%, Missing); small intestine: 98.4848% (minimum 99%, Missing); spinal cord: 84.4156% (minimum 99%, Missing); spleen: 94.2029% (minimum 95%, Missing); stomach: 90.2778% (minimum 97%, Missing)",-0.0214286,-0.932165,-0.251364,0,80,unavailable,2.3,165.3,0.5,"salivary gland: 165.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137976,DNASE2B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 73.8636% (minimum 75%, Missing); salivary gland: 3.7835% (minimum 70%, Missing)",0.278571,-0.662165,-0.0113636,0,80,unavailable,2.3,165.3,0.5,"salivary gland: 165.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137976,DNASE2B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 73.8636% (minimum 75%, Missing); salivary gland: 3.7835% (minimum 70%, Missing)",0.278571,-0.662165,-0.0113636,0,80,unavailable,2.3,165.3,0.5,"salivary gland: 165.3 nTPM (protected, limit 3); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137976,DNASE2B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 73.8636% (minimum 75%, Missing); salivary gland: 3.7835% (minimum 70%, Missing)",0.278571,-0.662165,-0.0113636,0,80,unavailable,2.3,165.3,0.5,"salivary gland: 165.3 nTPM (protected, limit 3); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137976,DNASE2B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 73.8636% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 3.7835% (minimum 70%, Baseline (adaptation disabled))",0.278571,-0.662165,-0.0113636,0,80,unavailable,2.3,165.3,0.5,"salivary gland: 165.3 nTPM (protected, limit 3); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000137976,DNASE2B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 85.7143% (minimum 99%, Missing); esophagus: 90.0000% (minimum 97%, Missing)",0.05,-0.07,-0.132857,0,80,unavailable,0.3,0.2,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000138068,SULT6B1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.2,0.107143,0,80,unavailable,0.3,0.2,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000138068,SULT6B1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.2,0.107143,0,80,unavailable,0.3,0.2,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000138068,SULT6B1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.2,0.107143,0,80,unavailable,0.3,0.2,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000138068,SULT6B1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.2,0.107143,0,80,unavailable,0.3,0.2,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000138068,SULT6B1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3636% (minimum 95%, Missing); adrenal gland: 67.5000% (minimum 99%, Missing); amygdala: 65.8537% (minimum 99%, Missing); basal ganglia: 65.8537% (minimum 99%, Missing); bone marrow: 47.0930% (minimum 99%, Missing); cerebellum: 66.9421% (minimum 99%, Missing); cerebral cortex: 62.7907% (minimum 99%, Missing); choroid plexus: 77.8846% (minimum 99%, Missing); colon: 71.6814% (minimum 97%, Missing); duodenum: 72.3214% (minimum 99%, Missing); esophagus: 64.8000% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); hippocampal formation: 65.3226% (minimum 99%, Missing); hypothalamus: 66.9421% (minimum 99%, Missing); kidney: 74.3119% (minimum 99%, Missing); liver: 76.4151% (minimum 99%, Missing); lung: 69.8276% (minimum 99%, Missing); lymph node: 62.7907% (minimum 97%, Missing); midbrain: 66.9421% (minimum 99%, Missing); pancreas: 81.0000% (minimum 99%, Missing); parathyroid gland: 84.3750% (minimum 97%, Missing); pituitary gland: 69.8276% (minimum 99%, Missing); rectum: 69.2308% (minimum 97%, Missing); retina: 85.2632% (minimum 99%, Missing); salivary gland: 76.4151% (minimum 97%, Missing); skeletal muscle: 73.6364% (minimum 99%, Missing); skin: 68.6441% (minimum 95%, Missing); small intestine: 68.0672% (minimum 99%, Missing); smooth muscle: 79.4118% (minimum 99%, Missing); spinal cord: 68.6441% (minimum 99%, Missing); spleen: 65.8537% (minimum 95%, Missing); stomach: 75.7009% (minimum 97%, Missing); thymus: 42.1875% (minimum 95%, Missing); thyroid gland: 71.0526% (minimum 95%, Missing); tongue: 81.0000% (minimum 97%, Missing); urinary bladder: 77.1429% (minimum 97%, Missing)",-0.528125,-0.342093,-0.51907,0,80,unavailable,9.1,4.8,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); hippocampal formation: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138092,CENPO,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3636% (minimum 65%, Missing); adrenal gland: 67.5000% (minimum 75%, Missing); amygdala: 65.8537% (minimum 75%, Missing); basal ganglia: 65.8537% (minimum 75%, Missing); bone marrow: 47.0930% (minimum 75%, Missing); cerebellum: 66.9421% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); duodenum: 72.3214% (minimum 75%, Missing); esophagus: 64.8000% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); hippocampal formation: 65.3226% (minimum 75%, Missing); hypothalamus: 66.9421% (minimum 75%, Missing); kidney: 74.3119% (minimum 75%, Missing); lung: 69.8276% (minimum 75%, Missing); lymph node: 62.7907% (minimum 70%, Missing); midbrain: 66.9421% (minimum 75%, Missing); pituitary gland: 69.8276% (minimum 75%, Missing); rectum: 69.2308% (minimum 70%, Missing); skeletal muscle: 73.6364% (minimum 75%, Missing); small intestine: 68.0672% (minimum 75%, Missing); spinal cord: 68.6441% (minimum 75%, Missing); thymus: 42.1875% (minimum 65%, Missing)",-0.228125,-0.072093,-0.27907,0,80,unavailable,9.1,4.8,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); hippocampal formation: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138092,CENPO,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3636% (minimum 65%, Missing); adrenal gland: 67.5000% (minimum 75%, Missing); amygdala: 65.8537% (minimum 75%, Missing); basal ganglia: 65.8537% (minimum 75%, Missing); bone marrow: 47.0930% (minimum 75%, Missing); cerebellum: 66.9421% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); duodenum: 72.3214% (minimum 75%, Missing); esophagus: 64.8000% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); hippocampal formation: 65.3226% (minimum 75%, Missing); hypothalamus: 66.9421% (minimum 75%, Missing); kidney: 74.3119% (minimum 75%, Missing); lung: 69.8276% (minimum 75%, Missing); lymph node: 62.7907% (minimum 70%, Missing); midbrain: 66.9421% (minimum 75%, Missing); pituitary gland: 69.8276% (minimum 75%, Missing); rectum: 69.2308% (minimum 70%, Missing); skeletal muscle: 73.6364% (minimum 75%, Missing); small intestine: 68.0672% (minimum 75%, Missing); spinal cord: 68.6441% (minimum 75%, Missing); thymus: 42.1875% (minimum 65%, Missing)",-0.228125,-0.072093,-0.27907,0,80,unavailable,9.1,4.8,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); lymph node: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 3); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138092,CENPO,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3636% (minimum 65%, Missing); adrenal gland: 67.5000% (minimum 75%, Missing); amygdala: 65.8537% (minimum 75%, Missing); basal ganglia: 65.8537% (minimum 75%, Missing); bone marrow: 47.0930% (minimum 75%, Missing); cerebellum: 66.9421% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); duodenum: 72.3214% (minimum 75%, Missing); esophagus: 64.8000% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); hippocampal formation: 65.3226% (minimum 75%, Missing); hypothalamus: 66.9421% (minimum 75%, Missing); kidney: 74.3119% (minimum 75%, Missing); lung: 69.8276% (minimum 75%, Missing); lymph node: 62.7907% (minimum 70%, Missing); midbrain: 66.9421% (minimum 75%, Missing); pituitary gland: 69.8276% (minimum 75%, Missing); rectum: 69.2308% (minimum 70%, Missing); skeletal muscle: 73.6364% (minimum 75%, Missing); small intestine: 68.0672% (minimum 75%, Missing); spinal cord: 68.6441% (minimum 75%, Missing); thymus: 42.1875% (minimum 65%, Missing)",-0.228125,-0.072093,-0.27907,0,80,unavailable,9.1,4.8,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); lymph node: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 3); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138092,CENPO,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3636% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 67.5000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.8537% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.8537% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 47.0930% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 66.9421% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.7907% (minimum 75%, Baseline (adaptation disabled)); duodenum: 72.3214% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.8000% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.3226% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.9421% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.3119% (minimum 75%, Baseline (adaptation disabled)); lung: 69.8276% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.7907% (minimum 70%, Baseline (adaptation disabled)); midbrain: 66.9421% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 69.8276% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.2308% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 73.6364% (minimum 75%, Baseline (adaptation disabled)); small intestine: 68.0672% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.6441% (minimum 75%, Baseline (adaptation disabled)); thymus: 42.1875% (minimum 65%, Baseline (adaptation disabled))",-0.228125,-0.072093,-0.27907,0,80,unavailable,9.1,4.8,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); lymph node: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 3); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138092,CENPO,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.6429% (minimum 95%, Enhanced); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 62.9032% (minimum 99%, Missing); cerebellum: 81.2500% (minimum 95%, Enhanced); cerebral cortex: 67.2414% (minimum 95%, Enhanced); choroid plexus: 82.9787% (minimum 99%, Missing); colon: 90.6977% (minimum 97%, Missing); heart muscle: 92.8571% (minimum 95%, Enhanced); hippocampal formation: 73.5849% (minimum 99%, Missing); hypothalamus: 60.9375% (minimum 99%, Missing); kidney: 73.5849% (minimum 95%, Enhanced); liver: 0.1864% (minimum 99%, Missing); lung: 90.6977% (minimum 95%, Enhanced); midbrain: 79.5918% (minimum 99%, Missing); pancreas: 70.9091% (minimum 95%, Enhanced); pituitary gland: 56.5217% (minimum 99%, Missing); retina: 56.5217% (minimum 99%, Missing); small intestine: 78.0000% (minimum 99%, Missing); spinal cord: 78.0000% (minimum 99%, Missing); stomach: 40.2062% (minimum 80%, Enhanced)",0.00121951,-0.397938,-0.988136,0,6,partial,2088.7,5.8,1,"liver: 2088.7 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138115,CYP2C8,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 62.9032% (minimum 75%, Missing); hippocampal formation: 73.5849% (minimum 75%, Missing); hypothalamus: 60.9375% (minimum 75%, Missing); liver: 0.1864% (minimum 75%, Missing); pituitary gland: 56.5217% (minimum 75%, Missing); retina: 56.5217% (minimum 75%, Missing); stomach: 40.2062% (minimum 55%, Enhanced)",0.295918,-0.147938,-0.748136,0,6,partial,2088.7,5.8,1,"liver: 2088.7 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138115,CYP2C8,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 62.9032% (minimum 75%, Missing); hippocampal formation: 73.5849% (minimum 75%, Missing); hypothalamus: 60.9375% (minimum 75%, Missing); liver: 0.1864% (minimum 75%, Missing); pituitary gland: 56.5217% (minimum 75%, Missing); retina: 56.5217% (minimum 75%, Missing); stomach: 40.2062% (minimum 55%, Enhanced)",0.295918,-0.147938,-0.748136,0,6,partial,2088.7,5.8,1,"liver: 2088.7 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138115,CYP2C8,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 62.9032% (minimum 75%, Missing); hippocampal formation: 73.5849% (minimum 75%, Missing); hypothalamus: 60.9375% (minimum 75%, Missing); liver: 0.1864% (minimum 75%, Missing); pituitary gland: 56.5217% (minimum 75%, Missing); retina: 56.5217% (minimum 75%, Missing); stomach: 40.2062% (minimum 55%, Enhanced)",0.295918,-0.147938,-0.748136,0,6,partial,2088.7,5.8,1,"liver: 2088.7 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138115,CYP2C8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.6429% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.9032% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 67.2414% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.5849% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.9375% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.5849% (minimum 75%, Baseline (adaptation disabled)); liver: 0.1864% (minimum 75%, Baseline (adaptation disabled)); pancreas: 70.9091% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 56.5217% (minimum 75%, Baseline (adaptation disabled)); retina: 56.5217% (minimum 75%, Baseline (adaptation disabled)); stomach: 40.2062% (minimum 70%, Baseline (adaptation disabled))",0.145918,-0.297938,-0.748136,0,6,partial,2088.7,5.8,1,"liver: 2088.7 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 3); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138115,CYP2C8,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.5405% (minimum 99%, Missing); amygdala: 98.5294% (minimum 99%, Missing); basal ganglia: 98.5294% (minimum 99%, Missing); bone marrow: 39.8810% (minimum 99%, Missing); cerebellum: 93.0556% (minimum 97%, Supported); cerebral cortex: 89.3333% (minimum 99%, Missing); choroid plexus: 98.5294% (minimum 99%, Missing); colon: 68.3673% (minimum 97%, Missing); duodenum: 65.6863% (minimum 97%, Supported); esophagus: 68.3673% (minimum 97%, Missing); heart muscle: 88.1579% (minimum 97%, Supported); hippocampal formation: 98.5294% (minimum 99%, Missing); hypothalamus: 98.5294% (minimum 99%, Missing); kidney: 84.8101% (minimum 99%, Missing); liver: 83.7500% (minimum 99%, Missing); lung: 82.7160% (minimum 97%, Supported); lymph node: 46.2069% (minimum 97%, Missing); midbrain: 98.5294% (minimum 99%, Missing); pancreas: 90.5405% (minimum 99%, Missing); parathyroid gland: 85.8974% (minimum 90%, Supported); pituitary gland: 97.1014% (minimum 99%, Missing); rectum: 63.2075% (minimum 97%, Missing); retina: 85.8974% (minimum 99%, Missing); salivary gland: 87.0130% (minimum 97%, Missing); skeletal muscle: 94.3662% (minimum 97%, Supported); skin: 73.6264% (minimum 95%, Missing); small intestine: 67.0000% (minimum 97%, Supported); smooth muscle: 76.1364% (minimum 97%, Supported); spinal cord: 98.5294% (minimum 99%, Missing); spleen: 67.6768% (minimum 95%, Missing); stomach: 73.6264% (minimum 97%, Missing); thymus: 41.1043% (minimum 95%, Missing); thyroid gland: 79.7619% (minimum 80%, Supported); tongue: 91.7808% (minimum 97%, Missing); urinary bladder: 80.7229% (minimum 90%, Supported)",-0.538957,-0.507931,-0.59119,0,9,partial,10.1,7.8,9.6,"bone marrow: 10.1 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 3); small intestine: 3.3 nTPM (vital, limit 3); colon: 3.1 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Medium (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Low (Supported); skin 1 / lymphocytes: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Low (Supported); skin 2 / fibrohistiocytic cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138182,KIF20B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 39.8810% (minimum 75%, Missing); colon: 68.3673% (minimum 70%, Missing); esophagus: 68.3673% (minimum 70%, Missing); lymph node: 46.2069% (minimum 70%, Missing); rectum: 63.2075% (minimum 70%, Missing); thymus: 41.1043% (minimum 65%, Missing)",-0.238957,-0.237931,-0.35119,0,9,partial,10.1,7.8,9.6,"bone marrow: 10.1 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 3); small intestine: 3.3 nTPM (vital, limit 3); colon: 3.1 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Medium (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Low (Supported); skin 1 / lymphocytes: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Low (Supported); skin 2 / fibrohistiocytic cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138182,KIF20B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 39.8810% (minimum 75%, Missing); colon: 68.3673% (minimum 70%, Missing); esophagus: 68.3673% (minimum 70%, Missing); lymph node: 46.2069% (minimum 70%, Missing); rectum: 63.2075% (minimum 70%, Missing); thymus: 41.1043% (minimum 65%, Missing)",-0.238957,-0.237931,-0.35119,0,9,partial,10.1,7.8,9.6,"bone marrow: 10.1 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 3); small intestine: 3.3 nTPM (vital, limit 3); colon: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Medium (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Low (Supported); skin 1 / lymphocytes: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Low (Supported); skin 2 / fibrohistiocytic cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138182,KIF20B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 39.8810% (minimum 75%, Missing); colon: 68.3673% (minimum 70%, Missing); esophagus: 68.3673% (minimum 70%, Missing); lymph node: 46.2069% (minimum 70%, Missing); rectum: 63.2075% (minimum 70%, Missing); thymus: 41.1043% (minimum 65%, Missing)",-0.238957,-0.237931,-0.35119,0,9,partial,10.1,7.8,9.6,"bone marrow: 10.1 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 3); small intestine: 3.3 nTPM (vital, limit 3); colon: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Medium (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Low (Supported); skin 1 / lymphocytes: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Low (Supported); skin 2 / fibrohistiocytic cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138182,KIF20B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 39.8810% (minimum 75%, Baseline (adaptation disabled)); colon: 68.3673% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.6863% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.3673% (minimum 70%, Baseline (adaptation disabled)); lymph node: 46.2069% (minimum 70%, Baseline (adaptation disabled)); rectum: 63.2075% (minimum 70%, Baseline (adaptation disabled)); small intestine: 67.0000% (minimum 75%, Baseline (adaptation disabled)); thymus: 41.1043% (minimum 65%, Baseline (adaptation disabled))",-0.238957,-0.237931,-0.35119,0,9,partial,10.1,7.8,9.6,"bone marrow: 10.1 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Medium (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Low (Supported); skin 1 / lymphocytes: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Low (Supported); skin 2 / fibrohistiocytic cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138182,KIF20B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 85.7143% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 80.0000% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 63.1579% (minimum 99%, Missing); choroid plexus: 92.3077% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 92.3077% (minimum 99%, Missing); esophagus: 85.7143% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 80.0000% (minimum 99%, Missing); kidney: 80.0000% (minimum 99%, Missing); liver: 85.7143% (minimum 99%, Missing); lung: 85.7143% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 85.7143% (minimum 99%, Missing); parathyroid gland: 63.1579% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 80.0000% (minimum 97%, Missing); retina: 44.4444% (minimum 99%, Missing); salivary gland: 54.5455% (minimum 97%, Missing); skeletal muscle: 60.0000% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 85.7143% (minimum 99%, Missing); smooth muscle: 70.5882% (minimum 99%, Missing); spinal cord: 70.5882% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 75.0000% (minimum 97%, Missing); thymus: 38.7097% (minimum 95%, Missing); thyroid gland: 70.5882% (minimum 95%, Missing); tongue: 80.0000% (minimum 97%, Missing); urinary bladder: 85.7143% (minimum 97%, Missing)",-0.562903,-0.424545,-0.545556,0,80,unavailable,1.5,1,1.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138336,TET1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 63.1579% (minimum 75%, Missing); parathyroid gland: 63.1579% (minimum 70%, Missing); retina: 44.4444% (minimum 75%, Missing); salivary gland: 54.5455% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); smooth muscle: 70.5882% (minimum 75%, Missing); spinal cord: 70.5882% (minimum 75%, Missing); thymus: 38.7097% (minimum 65%, Missing)",-0.262903,-0.154545,-0.305556,0,80,unavailable,1.5,1,1.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138336,TET1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 63.1579% (minimum 75%, Missing); parathyroid gland: 63.1579% (minimum 70%, Missing); retina: 44.4444% (minimum 75%, Missing); salivary gland: 54.5455% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); smooth muscle: 70.5882% (minimum 75%, Missing); spinal cord: 70.5882% (minimum 75%, Missing); thymus: 38.7097% (minimum 65%, Missing)",-0.262903,-0.154545,-0.305556,0,80,unavailable,1.5,1,1.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138336,TET1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 63.1579% (minimum 75%, Missing); parathyroid gland: 63.1579% (minimum 70%, Missing); retina: 44.4444% (minimum 75%, Missing); salivary gland: 54.5455% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); smooth muscle: 70.5882% (minimum 75%, Missing); spinal cord: 70.5882% (minimum 75%, Missing); thymus: 38.7097% (minimum 65%, Missing)",-0.262903,-0.154545,-0.305556,0,80,unavailable,1.5,1,1.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138336,TET1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.1579% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.1579% (minimum 70%, Baseline (adaptation disabled)); retina: 44.4444% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 54.5455% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.5882% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.5882% (minimum 75%, Baseline (adaptation disabled)); thymus: 38.7097% (minimum 65%, Baseline (adaptation disabled))",-0.262903,-0.154545,-0.305556,0,80,unavailable,1.5,1,1.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138336,TET1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.0000% (minimum 90%, Approved); adrenal gland: 57.1429% (minimum 98%, Approved); amygdala: 63.1579% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); cerebellum: 60.0000% (minimum 98%, Approved); cerebral cortex: 63.1579% (minimum 98%, Approved); colon: 66.6667% (minimum 95%, Approved); duodenum: 85.7143% (minimum 98%, Approved); esophagus: 54.5455% (minimum 95%, Approved); heart muscle: 80.0000% (minimum 98%, Approved); hippocampal formation: 63.1579% (minimum 99%, Missing); hypothalamus: 63.1579% (minimum 99%, Missing); kidney: 70.5882% (minimum 98%, Approved); liver: 92.3077% (minimum 98%, Approved); lung: 85.7143% (minimum 98%, Approved); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 85.7143% (minimum 98%, Approved); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 75.0000% (minimum 95%, Approved); retina: 28.5714% (minimum 99%, Missing); salivary gland: 75.0000% (minimum 95%, Approved); skeletal muscle: 11.0092% (minimum 98%, Approved); skin: 70.5882% (minimum 90%, Approved); small intestine: 85.7143% (minimum 98%, Approved); smooth muscle: 80.0000% (minimum 98%, Approved); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 85.7143% (minimum 90%, Approved); stomach: 85.7143% (minimum 95%, Approved); thyroid gland: 80.0000% (minimum 90%, Approved); tongue: 7.5472% (minimum 97%, Missing); urinary bladder: 85.7143% (minimum 95%, Approved)",-0.194118,-0.894528,-0.869908,0,2,partial,9.7,14.7,0.5,"tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 9.7 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138379,MSTN,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.1429% (minimum 70%, Approved); amygdala: 63.1579% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 60.0000% (minimum 70%, Approved); cerebral cortex: 63.1579% (minimum 70%, Approved); esophagus: 54.5455% (minimum 65%, Approved); hippocampal formation: 63.1579% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); skeletal muscle: 11.0092% (minimum 70%, Approved); tongue: 7.5472% (minimum 70%, Missing)",0.105882,-0.624528,-0.589908,0,2,partial,9.7,14.7,0.5,"tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 9.7 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138379,MSTN,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.1429% (minimum 70%, Approved); amygdala: 63.1579% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 60.0000% (minimum 70%, Approved); cerebral cortex: 63.1579% (minimum 70%, Approved); esophagus: 54.5455% (minimum 65%, Approved); hippocampal formation: 63.1579% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); skeletal muscle: 11.0092% (minimum 70%, Approved); tongue: 7.5472% (minimum 70%, Missing)",0.105882,-0.624528,-0.589908,0,2,partial,9.7,14.7,0.5,"tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 9.7 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138379,MSTN,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.1429% (minimum 70%, Approved); amygdala: 63.1579% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 60.0000% (minimum 70%, Approved); cerebral cortex: 63.1579% (minimum 70%, Approved); esophagus: 54.5455% (minimum 65%, Approved); hippocampal formation: 63.1579% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); skeletal muscle: 11.0092% (minimum 70%, Approved); tongue: 7.5472% (minimum 70%, Missing)",0.105882,-0.624528,-0.589908,0,2,partial,9.7,14.7,0.5,"tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 9.7 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138379,MSTN,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.1429% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.1579% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.1579% (minimum 75%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 70%, Baseline (adaptation disabled)); esophagus: 54.5455% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 63.1579% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.1579% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.5882% (minimum 75%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 28.5714% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 11.0092% (minimum 75%, Baseline (adaptation disabled)); tongue: 7.5472% (minimum 70%, Baseline (adaptation disabled))",0.0558824,-0.624528,-0.639908,0,2,partial,9.7,14.7,0.5,"tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 9.7 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138379,MSTN,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.9365% (minimum 95%, Missing); adrenal gland: 80.3846% (minimum 99%, Missing); amygdala: 84.6154% (minimum 99%, Missing); basal ganglia: 84.9593% (minimum 99%, Missing); bone marrow: 79.7710% (minimum 99%, Missing); cerebellum: 81.9608% (minimum 99%, Missing); cerebral cortex: 74.1135% (minimum 99%, Missing); choroid plexus: 80.6950% (minimum 99%, Missing); colon: 80.3846% (minimum 97%, Missing); duodenum: 82.6087% (minimum 99%, Missing); esophagus: 79.7710% (minimum 97%, Missing); heart muscle: 81.3230% (minimum 99%, Missing); hippocampal formation: 82.9365% (minimum 99%, Missing); hypothalamus: 84.9593% (minimum 99%, Missing); kidney: 76.2774% (minimum 99%, Missing); liver: 82.9365% (minimum 99%, Missing); lung: 81.0078% (minimum 99%, Missing); lymph node: 70.8475% (minimum 97%, Missing); midbrain: 81.3230% (minimum 99%, Missing); pancreas: 84.6154% (minimum 99%, Missing); parathyroid gland: 73.3333% (minimum 97%, Missing); pituitary gland: 80.6950% (minimum 99%, Missing); rectum: 78.2772% (minimum 97%, Missing); retina: 57.2603% (minimum 99%, Missing); salivary gland: 82.2835% (minimum 97%, Missing); skeletal muscle: 82.9365% (minimum 99%, Missing); skin: 74.6429% (minimum 95%, Missing); small intestine: 81.3230% (minimum 99%, Missing); smooth muscle: 76.5568% (minimum 99%, Missing); spinal cord: 74.6429% (minimum 99%, Missing); spleen: 74.1135% (minimum 95%, Missing); stomach: 78.2772% (minimum 97%, Missing); thymus: 69.4352% (minimum 95%, Missing); thyroid gland: 66.9872% (minimum 95%, Missing); tongue: 80.0766% (minimum 97%, Missing); urinary bladder: 79.1667% (minimum 97%, Missing)",-0.280128,-0.261525,-0.417397,0,3,partial,15.6,8.6,10.3,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); lymph node: 8.6 nTPM (protected, limit 2); parathyroid gland: 7.6 nTPM (protected, limit 2); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); urinary bladder: 5.5 nTPM (protected, limit 2); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); tongue: 5.2 nTPM (protected, limit 2); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138380,CARF,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 74.1135% (minimum 75%, Missing); retina: 57.2603% (minimum 75%, Missing); spinal cord: 74.6429% (minimum 75%, Missing)",0.0198718,0.00847458,-0.177397,0,3,partial,15.6,8.6,10.3,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); lymph node: 8.6 nTPM (protected, limit 2); parathyroid gland: 7.6 nTPM (protected, limit 2); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); urinary bladder: 5.5 nTPM (protected, limit 2); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); tongue: 5.2 nTPM (protected, limit 2); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138380,CARF,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 74.1135% (minimum 75%, Missing); retina: 57.2603% (minimum 75%, Missing); spinal cord: 74.6429% (minimum 75%, Missing)",0.0198718,0.00847458,-0.177397,0,3,partial,15.6,8.6,10.3,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); lymph node: 8.6 nTPM (protected, limit 3); parathyroid gland: 7.6 nTPM (protected, limit 3); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); urinary bladder: 5.5 nTPM (protected, limit 3); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); tongue: 5.2 nTPM (protected, limit 3); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); duodenum: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138380,CARF,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 74.1135% (minimum 75%, Missing); retina: 57.2603% (minimum 75%, Missing); spinal cord: 74.6429% (minimum 75%, Missing)",0.0198718,0.00847458,-0.177397,0,3,partial,15.6,8.6,10.3,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); lymph node: 8.6 nTPM (protected, limit 3); parathyroid gland: 7.6 nTPM (protected, limit 3); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); urinary bladder: 5.5 nTPM (protected, limit 3); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); tongue: 5.2 nTPM (protected, limit 3); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); duodenum: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138380,CARF,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 74.1135% (minimum 75%, Baseline (adaptation disabled)); retina: 57.2603% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.6429% (minimum 75%, Baseline (adaptation disabled))",0.0198718,0.00847458,-0.177397,0,3,partial,15.6,8.6,10.3,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); lymph node: 8.6 nTPM (protected, limit 3); parathyroid gland: 7.6 nTPM (protected, limit 3); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); urinary bladder: 5.5 nTPM (protected, limit 3); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); tongue: 5.2 nTPM (protected, limit 3); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); duodenum: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138380,CARF,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.4444% (minimum 98%, Approved); amygdala: 91.1877% (minimum 99%, Missing); basal ganglia: 85.3047% (minimum 99%, Missing); cerebellum: 95.2000% (minimum 98%, Approved); cerebral cortex: 90.8397% (minimum 98%, Approved); choroid plexus: 53.9683% (minimum 99%, Missing); heart muscle: 95.2000% (minimum 98%, Approved); hippocampal formation: 90.1515% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); kidney: 88.8060% (minimum 98%, Approved); lung: 92.2481% (minimum 99%, Missing); midbrain: 91.1877% (minimum 99%, Missing); pancreas: 96.3563% (minimum 98%, Approved); parathyroid gland: 85.6115% (minimum 95%, Approved); pituitary gland: 72.5610% (minimum 99%, Missing); retina: 74.1433% (minimum 99%, Missing); smooth muscle: 96.7480% (minimum 98%, Approved); spinal cord: 94.8207% (minimum 99%, Missing); thyroid gland: 83.5088% (minimum 90%, Approved)",-0.0649123,-0.0938849,-0.450317,0,7,partial,20.3,4,4.7,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 2); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138400,MDH1B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 53.9683% (minimum 75%, Missing); pituitary gland: 72.5610% (minimum 75%, Missing); retina: 74.1433% (minimum 75%, Missing)",0.235088,0.206115,-0.210317,0,7,partial,20.3,4,4.7,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 2); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138400,MDH1B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 53.9683% (minimum 75%, Missing); pituitary gland: 72.5610% (minimum 75%, Missing); retina: 74.1433% (minimum 75%, Missing)",0.235088,0.206115,-0.210317,0,7,partial,20.3,4,4.7,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 2); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138400,MDH1B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 53.9683% (minimum 75%, Missing); pituitary gland: 72.5610% (minimum 75%, Missing); retina: 74.1433% (minimum 75%, Missing)",0.235088,0.206115,-0.210317,0,7,partial,20.3,4,4.7,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 2); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138400,MDH1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 53.9683% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 72.5610% (minimum 75%, Baseline (adaptation disabled)); retina: 74.1433% (minimum 75%, Baseline (adaptation disabled))",0.185088,0.156115,-0.210317,0,7,partial,20.3,4,4.7,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138400,MDH1B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.0491228,0.03,0.0038918,0,80,unavailable,0.7,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138483,CCDC54,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349123,0.3,0.243892,0,80,unavailable,0.7,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138483,CCDC54,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349123,0.3,0.243892,0,80,unavailable,0.7,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138483,CCDC54,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349123,0.3,0.243892,0,80,unavailable,0.7,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138483,CCDC54,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349123,0.3,0.243892,0,80,unavailable,0.7,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138483,CCDC54,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.0954% (minimum 99%, Missing); amygdala: 93.9759% (minimum 99%, Missing); basal ganglia: 91.5851% (minimum 99%, Missing); bone marrow: 91.2281% (minimum 99%, Missing); cerebellum: 86.1878% (minimum 99%, Missing); cerebral cortex: 95.7055% (minimum 99%, Missing); choroid plexus: 68.0233% (minimum 99%, Missing); colon: 96.2963% (minimum 97%, Missing); duodenum: 95.5102% (minimum 99%, Missing); esophagus: 94.7368% (minimum 97%, Missing); heart muscle: 95.1220% (minimum 99%, Missing); hippocampal formation: 91.9450% (minimum 99%, Missing); hypothalamus: 91.9450% (minimum 99%, Missing); kidney: 82.1053% (minimum 99%, Missing); liver: 96.0986% (minimum 99%, Missing); lung: 93.4132% (minimum 99%, Missing); midbrain: 94.9290% (minimum 99%, Missing); pancreas: 95.3157% (minimum 99%, Missing); pituitary gland: 93.2271% (minimum 99%, Missing); rectum: 95.9016% (minimum 97%, Missing); retina: 91.2281% (minimum 99%, Missing); salivary gland: 96.0986% (minimum 97%, Missing); skeletal muscle: 97.9079% (minimum 99%, Missing); small intestine: 95.9016% (minimum 99%, Missing); smooth muscle: 97.2973% (minimum 99%, Missing); spinal cord: 93.6000% (minimum 99%, Missing); stomach: 95.7055% (minimum 97%, Missing); thymus: 89.6552% (minimum 95%, Missing); thyroid gland: 94.3548% (minimum 95%, Missing)",-0.0534483,-0.0226316,-0.309767,0,80,unavailable,22,2.6,5.4,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); thymus: 5.4 nTPM (manageable, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138587,MNS1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.0233% (minimum 75%, Missing)",0.246552,0.247368,-0.0697674,0,80,unavailable,22,2.6,5.4,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); thymus: 5.4 nTPM (manageable, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138587,MNS1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.0233% (minimum 75%, Missing)",0.246552,0.247368,-0.0697674,0,80,unavailable,22,2.6,5.4,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); thymus: 5.4 nTPM (manageable, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138587,MNS1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.0233% (minimum 75%, Missing)",0.246552,0.247368,-0.0697674,0,80,unavailable,22,2.6,5.4,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); thymus: 5.4 nTPM (manageable, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138587,MNS1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.0233% (minimum 75%, Baseline (adaptation disabled))",0.246552,0.247368,-0.0697674,0,80,unavailable,22,2.6,5.4,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); thymus: 5.4 nTPM (manageable, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138587,MNS1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.6452% (minimum 99%, Missing); amygdala: 93.9799% (minimum 99%, Missing); basal ganglia: 94.2953% (minimum 99%, Missing); bone marrow: 75.1337% (minimum 97%, Supported); cerebral cortex: 94.7723% (minimum 97%, Supported); choroid plexus: 85.0227% (minimum 99%, Missing); colon: 93.6667% (minimum 97%, Missing); duodenum: 93.5108% (minimum 97%, Supported); heart muscle: 93.6667% (minimum 97%, Supported); hippocampal formation: 94.9324% (minimum 99%, Missing); hypothalamus: 95.0931% (minimum 99%, Missing); kidney: 90.0641% (minimum 99%, Missing); liver: 85.6707% (minimum 99%, Missing); lung: 89.9200% (minimum 97%, Supported); lymph node: 88.9241% (minimum 90%, Supported); midbrain: 94.1374% (minimum 99%, Missing); pancreas: 88.2261% (minimum 97%, Supported); parathyroid gland: 85.8015% (minimum 90%, Supported); pituitary gland: 93.3555% (minimum 99%, Missing); rectum: 95.7411% (minimum 97%, Missing); retina: 93.9799% (minimum 99%, Missing); salivary gland: 82.8909% (minimum 90%, Supported); small intestine: 92.5865% (minimum 99%, Missing); smooth muscle: 81.2139% (minimum 97%, Supported); spinal cord: 94.9324% (minimum 99%, Missing); stomach: 92.2824% (minimum 97%, Missing); thymus: 80.6313% (minimum 95%, Missing); tongue: 94.6128% (minimum 97%, Missing)",-0.143687,-0.0710914,-0.218663,0,3,partial,18.6,11.6,13.5,"bone marrow: 18.6 nTPM (vital, limit 3); thymus: 13.5 nTPM (manageable, limit 5); smooth muscle: 13 nTPM (vital, limit 3); salivary gland: 11.6 nTPM (protected, limit 6); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 6); pancreas: 7.5 nTPM (vital, limit 3); lymph node: 7 nTPM (protected, limit 6); lung: 6.3 nTPM (vital, limit 3); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 3); heart muscle: 3.8 nTPM (vital, limit 3); colon: 3.8 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138646,HERC5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.156313,0.222824,0.100227,0,3,partial,18.6,11.6,13.5,"bone marrow: 18.6 nTPM (vital, limit 3); thymus: 13.5 nTPM (manageable, limit 5); smooth muscle: 13 nTPM (vital, limit 3); salivary gland: 11.6 nTPM (protected, limit 6); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 6); pancreas: 7.5 nTPM (vital, limit 3); lymph node: 7 nTPM (protected, limit 6); lung: 6.3 nTPM (vital, limit 3); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 3); heart muscle: 3.8 nTPM (vital, limit 3); colon: 3.8 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138646,HERC5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.156313,0.222824,0.100227,0,3,partial,18.6,11.6,13.5,"bone marrow: 18.6 nTPM (vital, limit 3); thymus: 13.5 nTPM (manageable, limit 5); smooth muscle: 13 nTPM (vital, limit 3); salivary gland: 11.6 nTPM (protected, limit 6); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 6); pancreas: 7.5 nTPM (vital, limit 3); lymph node: 7 nTPM (protected, limit 6); lung: 6.3 nTPM (vital, limit 3); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 3); heart muscle: 3.8 nTPM (vital, limit 3); colon: 3.8 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138646,HERC5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.156313,0.222824,0.100227,0,3,partial,18.6,11.6,13.5,"bone marrow: 18.6 nTPM (vital, limit 3); thymus: 13.5 nTPM (manageable, limit 5); smooth muscle: 13 nTPM (vital, limit 3); salivary gland: 11.6 nTPM (protected, limit 6); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 6); pancreas: 7.5 nTPM (vital, limit 3); lymph node: 7 nTPM (protected, limit 6); lung: 6.3 nTPM (vital, limit 3); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 3); heart muscle: 3.8 nTPM (vital, limit 3); colon: 3.8 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138646,HERC5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.156313,0.128909,0.0013369,0,3,partial,18.6,11.6,13.5,"bone marrow: 18.6 nTPM (vital, limit 1); thymus: 13.5 nTPM (manageable, limit 5); smooth muscle: 13 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 5); salivary gland: 11.6 nTPM (protected, limit 3); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 3); pancreas: 7.5 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 3); lung: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); thyroid gland: 5.1 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 3); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); retina: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138646,HERC5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.5660% (minimum 95%, Missing); adrenal gland: 97.9592% (minimum 99%, Missing); amygdala: 82.7586% (minimum 99%, Missing); basal ganglia: 91.4286% (minimum 99%, Missing); bone marrow: 95.0495% (minimum 99%, Missing); cerebellum: 98.9691% (minimum 99%, Missing); cerebral cortex: 82.7586% (minimum 99%, Missing); choroid plexus: 98.9691% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); duodenum: 49.4845% (minimum 99%, Missing); esophagus: 77.4194% (minimum 97%, Missing); heart muscle: 69.0647% (minimum 99%, Missing); hippocampal formation: 86.4865% (minimum 99%, Missing); hypothalamus: 84.2105% (minimum 99%, Missing); kidney: 96.0000% (minimum 99%, Missing); liver: 98.9691% (minimum 99%, Missing); lung: 73.8462% (minimum 99%, Missing); midbrain: 88.0734% (minimum 99%, Missing); pancreas: 88.0734% (minimum 99%, Missing); pituitary gland: 82.0513% (minimum 99%, Missing); rectum: 76.8000% (minimum 97%, Missing); retina: 96.9697% (minimum 99%, Missing); salivary gland: 96.9697% (minimum 97%, Missing); skin: 89.7196% (minimum 95%, Missing); small intestine: 41.9214% (minimum 99%, Missing); smooth muscle: 95.0495% (minimum 99%, Missing); spinal cord: 94.1176% (minimum 99%, Missing); stomach: 91.4286% (minimum 97%, Missing); thymus: 90.5660% (minimum 95%, Missing); thyroid gland: 91.4286% (minimum 95%, Missing); urinary bladder: 95.0495% (minimum 97%, Missing)",-0.0528037,-0.202,-0.570786,0,0,routine_complete,13.3,2.9,1.1,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138669,PRKG2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 49.4845% (minimum 75%, Missing); heart muscle: 69.0647% (minimum 75%, Missing); lung: 73.8462% (minimum 75%, Missing); small intestine: 41.9214% (minimum 75%, Missing)",0.247196,0.068,-0.330786,0,0,routine_complete,13.3,2.9,1.1,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138669,PRKG2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 49.4845% (minimum 75%, Missing); heart muscle: 69.0647% (minimum 75%, Missing); lung: 73.8462% (minimum 75%, Missing); small intestine: 41.9214% (minimum 75%, Missing)",0.247196,0.068,-0.330786,0,0,routine_complete,13.3,2.9,1.1,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138669,PRKG2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 49.4845% (minimum 75%, Missing); heart muscle: 69.0647% (minimum 75%, Missing); lung: 73.8462% (minimum 75%, Missing); small intestine: 41.9214% (minimum 75%, Missing)",0.247196,0.068,-0.330786,0,0,routine_complete,13.3,2.9,1.1,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138669,PRKG2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 49.4845% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 69.0647% (minimum 75%, Baseline (adaptation disabled)); lung: 73.8462% (minimum 75%, Baseline (adaptation disabled)); small intestine: 41.9214% (minimum 75%, Baseline (adaptation disabled))",0.247196,0.068,-0.330786,0,0,routine_complete,13.3,2.9,1.1,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138669,PRKG2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 10.7692% (minimum 97%, Missing); spleen: 87.5000% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thymus: 87.5000% (minimum 95%, Missing); urinary bladder: 77.7778% (minimum 97%, Missing)",-0.075,-0.862308,0.01,0,80,unavailable,0,5.8,0.1,"lymph node: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138684,IL21,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 10.7692% (minimum 70%, Missing)",0.225,-0.592308,0.25,0,80,unavailable,0,5.8,0.1,"lymph node: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138684,IL21,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 10.7692% (minimum 70%, Missing)",0.225,-0.592308,0.25,0,80,unavailable,0,5.8,0.1,"lymph node: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138684,IL21,grid_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 10.7692% (minimum 70%, Missing)",0.225,-0.592308,0.25,0,80,unavailable,0,5.8,0.1,"lymph node: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138684,IL21,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 10.7692% (minimum 70%, Baseline (adaptation disabled))",0.225,-0.592308,0.25,0,80,unavailable,0,5.8,0.1,"lymph node: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138684,IL21,current_fixed,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.8580% (minimum 90%, Approved); adrenal gland: 62.6168% (minimum 98%, Approved); amygdala: 55.2198% (minimum 99%, Missing); basal ganglia: 50.6297% (minimum 99%, Missing); bone marrow: 51.2102% (minimum 98%, Approved); cerebellum: 48.6683% (minimum 98%, Approved); cerebral cortex: 52.3438% (minimum 98%, Approved); choroid plexus: 54.9180% (minimum 99%, Missing); colon: 58.4302% (minimum 97%, Missing); duodenum: 77.6062% (minimum 99%, Missing); esophagus: 70.4028% (minimum 95%, Approved); heart muscle: 64.5265% (minimum 99%, Missing); hippocampal formation: 54.9180% (minimum 99%, Missing); hypothalamus: 58.7719% (minimum 99%, Missing); kidney: 62.0370% (minimum 99%, Missing); liver: 69.3103% (minimum 98%, Approved); lung: 59.7325% (minimum 99%, Missing); lymph node: 77.6062% (minimum 95%, Approved); midbrain: 54.3243% (minimum 99%, Missing); pancreas: 62.6168% (minimum 99%, Missing); parathyroid gland: 49.5684% (minimum 95%, Approved); pituitary gland: 46.6899% (minimum 99%, Missing); rectum: 74.1697% (minimum 97%, Missing); retina: 39.9602% (minimum 99%, Missing); salivary gland: 64.9435% (minimum 95%, Approved); skeletal muscle: 50.0623% (minimum 98%, Approved); skin: 65.1540% (minimum 95%, Missing); small intestine: 59.4675% (minimum 99%, Missing); smooth muscle: 74.4444% (minimum 99%, Missing); spinal cord: 50.0623% (minimum 99%, Missing); spleen: 61.0015% (minimum 90%, Approved); stomach: 64.1148% (minimum 97%, Missing); thymus: 71.0247% (minimum 95%, Missing); thyroid gland: 57.0213% (minimum 95%, Missing); tongue: 54.9932% (minimum 97%, Missing); urinary bladder: 62.9108% (minimum 97%, Missing)",-0.379787,-0.454316,-0.590398,0,7,partial,60.4,40.9,30.3,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 2); parathyroid gland: 40.9 nTPM (protected, limit 4); spinal cord: 40.1 nTPM (vital, limit 1); skeletal muscle: 40.1 nTPM (vital, limit 2); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 2); cerebral cortex: 36.6 nTPM (vital, limit 2); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 2); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 2); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (manageable, limit 10); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); spleen: 25.7 nTPM (manageable, limit 10); kidney: 24.6 nTPM (vital, limit 1); pancreas: 24 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 2); urinary bladder: 23.7 nTPM (protected, limit 2); stomach: 22.5 nTPM (protected, limit 2); heart muscle: 22.1 nTPM (vital, limit 1); salivary gland: 21.7 nTPM (protected, limit 4); skin: 21.5 nTPM (manageable, limit 5); liver: 17.8 nTPM (vital, limit 2); esophagus: 16.9 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 14 nTPM (protected, limit 2); smooth muscle: 13.8 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 4); duodenum: 11.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138688,BLTP1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.8580% (minimum 60%, Approved); adrenal gland: 62.6168% (minimum 70%, Approved); amygdala: 55.2198% (minimum 75%, Missing); basal ganglia: 50.6297% (minimum 75%, Missing); bone marrow: 51.2102% (minimum 70%, Approved); cerebellum: 48.6683% (minimum 70%, Approved); cerebral cortex: 52.3438% (minimum 70%, Approved); choroid plexus: 54.9180% (minimum 75%, Missing); colon: 58.4302% (minimum 70%, Missing); heart muscle: 64.5265% (minimum 75%, Missing); hippocampal formation: 54.9180% (minimum 75%, Missing); hypothalamus: 58.7719% (minimum 75%, Missing); kidney: 62.0370% (minimum 75%, Missing); liver: 69.3103% (minimum 70%, Approved); lung: 59.7325% (minimum 75%, Missing); midbrain: 54.3243% (minimum 75%, Missing); pancreas: 62.6168% (minimum 75%, Missing); parathyroid gland: 49.5684% (minimum 65%, Approved); pituitary gland: 46.6899% (minimum 75%, Missing); retina: 39.9602% (minimum 75%, Missing); salivary gland: 64.9435% (minimum 65%, Approved); skeletal muscle: 50.0623% (minimum 70%, Approved); small intestine: 59.4675% (minimum 75%, Missing); smooth muscle: 74.4444% (minimum 75%, Missing); spinal cord: 50.0623% (minimum 75%, Missing); stomach: 64.1148% (minimum 70%, Missing); thyroid gland: 57.0213% (minimum 65%, Missing); tongue: 54.9932% (minimum 70%, Missing); urinary bladder: 62.9108% (minimum 70%, Missing)",-0.0797872,-0.154316,-0.350398,0,7,partial,60.4,40.9,30.3,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 2); parathyroid gland: 40.9 nTPM (protected, limit 4); spinal cord: 40.1 nTPM (vital, limit 1); skeletal muscle: 40.1 nTPM (vital, limit 2); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 2); cerebral cortex: 36.6 nTPM (vital, limit 2); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 2); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 2); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (manageable, limit 10); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); spleen: 25.7 nTPM (manageable, limit 10); kidney: 24.6 nTPM (vital, limit 1); pancreas: 24 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 2); urinary bladder: 23.7 nTPM (protected, limit 2); stomach: 22.5 nTPM (protected, limit 2); heart muscle: 22.1 nTPM (vital, limit 1); salivary gland: 21.7 nTPM (protected, limit 4); skin: 21.5 nTPM (manageable, limit 5); liver: 17.8 nTPM (vital, limit 2); esophagus: 16.9 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 14 nTPM (protected, limit 2); smooth muscle: 13.8 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 4); duodenum: 11.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138688,BLTP1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.8580% (minimum 60%, Approved); adrenal gland: 62.6168% (minimum 70%, Approved); amygdala: 55.2198% (minimum 75%, Missing); basal ganglia: 50.6297% (minimum 75%, Missing); bone marrow: 51.2102% (minimum 70%, Approved); cerebellum: 48.6683% (minimum 70%, Approved); cerebral cortex: 52.3438% (minimum 70%, Approved); choroid plexus: 54.9180% (minimum 75%, Missing); colon: 58.4302% (minimum 70%, Missing); heart muscle: 64.5265% (minimum 75%, Missing); hippocampal formation: 54.9180% (minimum 75%, Missing); hypothalamus: 58.7719% (minimum 75%, Missing); kidney: 62.0370% (minimum 75%, Missing); liver: 69.3103% (minimum 70%, Approved); lung: 59.7325% (minimum 75%, Missing); midbrain: 54.3243% (minimum 75%, Missing); pancreas: 62.6168% (minimum 75%, Missing); parathyroid gland: 49.5684% (minimum 65%, Approved); pituitary gland: 46.6899% (minimum 75%, Missing); retina: 39.9602% (minimum 75%, Missing); salivary gland: 64.9435% (minimum 65%, Approved); skeletal muscle: 50.0623% (minimum 70%, Approved); small intestine: 59.4675% (minimum 75%, Missing); smooth muscle: 74.4444% (minimum 75%, Missing); spinal cord: 50.0623% (minimum 75%, Missing); stomach: 64.1148% (minimum 70%, Missing); thyroid gland: 57.0213% (minimum 65%, Missing); tongue: 54.9932% (minimum 70%, Missing); urinary bladder: 62.9108% (minimum 70%, Missing)",-0.0797872,-0.154316,-0.350398,0,7,partial,60.4,40.9,30.3,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 2); parathyroid gland: 40.9 nTPM (protected, limit 4); spinal cord: 40.1 nTPM (vital, limit 1); skeletal muscle: 40.1 nTPM (vital, limit 2); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 2); cerebral cortex: 36.6 nTPM (vital, limit 2); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 3); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 3); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (manageable, limit 10); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); spleen: 25.7 nTPM (manageable, limit 10); kidney: 24.6 nTPM (vital, limit 1); pancreas: 24 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 2); urinary bladder: 23.7 nTPM (protected, limit 3); stomach: 22.5 nTPM (protected, limit 3); heart muscle: 22.1 nTPM (vital, limit 1); salivary gland: 21.7 nTPM (protected, limit 4); skin: 21.5 nTPM (manageable, limit 5); liver: 17.8 nTPM (vital, limit 2); esophagus: 16.9 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 14 nTPM (protected, limit 3); smooth muscle: 13.8 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 4); duodenum: 11.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138688,BLTP1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.8580% (minimum 60%, Approved); adrenal gland: 62.6168% (minimum 70%, Approved); amygdala: 55.2198% (minimum 75%, Missing); basal ganglia: 50.6297% (minimum 75%, Missing); bone marrow: 51.2102% (minimum 70%, Approved); cerebellum: 48.6683% (minimum 70%, Approved); cerebral cortex: 52.3438% (minimum 70%, Approved); choroid plexus: 54.9180% (minimum 75%, Missing); colon: 58.4302% (minimum 70%, Missing); heart muscle: 64.5265% (minimum 75%, Missing); hippocampal formation: 54.9180% (minimum 75%, Missing); hypothalamus: 58.7719% (minimum 75%, Missing); kidney: 62.0370% (minimum 75%, Missing); liver: 69.3103% (minimum 70%, Approved); lung: 59.7325% (minimum 75%, Missing); midbrain: 54.3243% (minimum 75%, Missing); pancreas: 62.6168% (minimum 75%, Missing); parathyroid gland: 49.5684% (minimum 65%, Approved); pituitary gland: 46.6899% (minimum 75%, Missing); retina: 39.9602% (minimum 75%, Missing); salivary gland: 64.9435% (minimum 65%, Approved); skeletal muscle: 50.0623% (minimum 70%, Approved); small intestine: 59.4675% (minimum 75%, Missing); smooth muscle: 74.4444% (minimum 75%, Missing); spinal cord: 50.0623% (minimum 75%, Missing); stomach: 64.1148% (minimum 70%, Missing); thyroid gland: 57.0213% (minimum 65%, Missing); tongue: 54.9932% (minimum 70%, Missing); urinary bladder: 62.9108% (minimum 70%, Missing)",-0.0797872,-0.154316,-0.350398,0,7,partial,60.4,40.9,30.3,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 2); parathyroid gland: 40.9 nTPM (protected, limit 4); spinal cord: 40.1 nTPM (vital, limit 1); skeletal muscle: 40.1 nTPM (vital, limit 2); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 2); cerebral cortex: 36.6 nTPM (vital, limit 2); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 3); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 3); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (manageable, limit 10); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); spleen: 25.7 nTPM (manageable, limit 10); kidney: 24.6 nTPM (vital, limit 1); pancreas: 24 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 2); urinary bladder: 23.7 nTPM (protected, limit 3); stomach: 22.5 nTPM (protected, limit 3); heart muscle: 22.1 nTPM (vital, limit 1); salivary gland: 21.7 nTPM (protected, limit 4); skin: 21.5 nTPM (manageable, limit 5); liver: 17.8 nTPM (vital, limit 2); esophagus: 16.9 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 14 nTPM (protected, limit 3); smooth muscle: 13.8 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 4); duodenum: 11.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138688,BLTP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.8580% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.6168% (minimum 75%, Baseline (adaptation disabled)); amygdala: 55.2198% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 50.6297% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 51.2102% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.6683% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 52.3438% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 54.9180% (minimum 75%, Baseline (adaptation disabled)); colon: 58.4302% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.5265% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.9180% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.7719% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.0370% (minimum 75%, Baseline (adaptation disabled)); liver: 69.3103% (minimum 75%, Baseline (adaptation disabled)); lung: 59.7325% (minimum 75%, Baseline (adaptation disabled)); midbrain: 54.3243% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.6168% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.5684% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 46.6899% (minimum 75%, Baseline (adaptation disabled)); retina: 39.9602% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.9435% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 50.0623% (minimum 75%, Baseline (adaptation disabled)); small intestine: 59.4675% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 74.4444% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.0623% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.0015% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.1148% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 57.0213% (minimum 65%, Baseline (adaptation disabled)); tongue: 54.9932% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.9108% (minimum 70%, Baseline (adaptation disabled))",-0.0797872,-0.204316,-0.350398,0,7,partial,60.4,40.9,30.3,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 1); parathyroid gland: 40.9 nTPM (protected, limit 3); spinal cord: 40.1 nTPM (vital, limit 1); skeletal muscle: 40.1 nTPM (vital, limit 1); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 1); cerebral cortex: 36.6 nTPM (vital, limit 1); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 3); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 3); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (manageable, limit 5); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); spleen: 25.7 nTPM (manageable, limit 5); kidney: 24.6 nTPM (vital, limit 1); pancreas: 24 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 1); urinary bladder: 23.7 nTPM (protected, limit 3); stomach: 22.5 nTPM (protected, limit 3); heart muscle: 22.1 nTPM (vital, limit 1); salivary gland: 21.7 nTPM (protected, limit 3); skin: 21.5 nTPM (manageable, limit 5); liver: 17.8 nTPM (vital, limit 1); esophagus: 16.9 nTPM (protected, limit 3); thymus: 16.4 nTPM (manageable, limit 5); rectum: 14 nTPM (protected, limit 3); smooth muscle: 13.8 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 3); duodenum: 11.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138688,BLTP1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 97.5610% (minimum 99%, Missing); basal ganglia: 95.2381% (minimum 99%, Missing); bone marrow: 28.7770% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 95%, Enhanced); colon: 70.1754% (minimum 80%, Enhanced); duodenum: 72.7273% (minimum 99%, Missing); esophagus: 67.7966% (minimum 97%, Missing); heart muscle: 95.2381% (minimum 99%, Missing); hippocampal formation: 97.5610% (minimum 99%, Missing); hypothalamus: 95.2381% (minimum 99%, Missing); kidney: 95.2381% (minimum 99%, Missing); liver: 88.8889% (minimum 99%, Missing); lung: 85.1064% (minimum 99%, Missing); lymph node: 42.1053% (minimum 97%, Missing); midbrain: 95.2381% (minimum 99%, Missing); rectum: 67.7966% (minimum 97%, Missing); retina: 90.9091% (minimum 99%, Missing); salivary gland: 93.0233% (minimum 97%, Missing); skin: 67.7966% (minimum 95%, Missing); small intestine: 71.4286% (minimum 95%, Enhanced); smooth muscle: 78.4314% (minimum 99%, Missing); spinal cord: 95.2381% (minimum 99%, Missing); stomach: 80.0000% (minimum 97%, Missing); thymus: 31.0078% (minimum 95%, Missing); tongue: 86.9565% (minimum 97%, Missing); urinary bladder: 85.1064% (minimum 97%, Missing)",-0.639922,-0.548947,-0.70223,0,7,partial,9.9,5.5,8.9,"bone marrow: 9.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: High (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138778,CENPE,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 28.7770% (minimum 75%, Missing); duodenum: 72.7273% (minimum 75%, Missing); esophagus: 67.7966% (minimum 70%, Missing); lymph node: 42.1053% (minimum 70%, Missing); rectum: 67.7966% (minimum 70%, Missing); thymus: 31.0078% (minimum 65%, Missing)",-0.339922,-0.278947,-0.46223,0,7,partial,9.9,5.5,8.9,"bone marrow: 9.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: High (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138778,CENPE,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 28.7770% (minimum 75%, Missing); duodenum: 72.7273% (minimum 75%, Missing); esophagus: 67.7966% (minimum 70%, Missing); lymph node: 42.1053% (minimum 70%, Missing); rectum: 67.7966% (minimum 70%, Missing); thymus: 31.0078% (minimum 65%, Missing)",-0.339922,-0.278947,-0.46223,0,7,partial,9.9,5.5,8.9,"bone marrow: 9.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: High (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138778,CENPE,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 28.7770% (minimum 75%, Missing); duodenum: 72.7273% (minimum 75%, Missing); esophagus: 67.7966% (minimum 70%, Missing); lymph node: 42.1053% (minimum 70%, Missing); rectum: 67.7966% (minimum 70%, Missing); thymus: 31.0078% (minimum 65%, Missing)",-0.339922,-0.278947,-0.46223,0,7,partial,9.9,5.5,8.9,"bone marrow: 9.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: High (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138778,CENPE,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 28.7770% (minimum 75%, Baseline (adaptation disabled)); duodenum: 72.7273% (minimum 75%, Baseline (adaptation disabled)); esophagus: 67.7966% (minimum 70%, Baseline (adaptation disabled)); lymph node: 42.1053% (minimum 70%, Baseline (adaptation disabled)); rectum: 67.7966% (minimum 70%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 75%, Baseline (adaptation disabled)); thymus: 31.0078% (minimum 65%, Baseline (adaptation disabled))",-0.339922,-0.278947,-0.46223,0,7,partial,9.9,5.5,8.9,"bone marrow: 9.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: High (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138778,CENPE,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Missing); adrenal gland: 82.0312% (minimum 99%, Missing); amygdala: 84.0000% (minimum 99%, Missing); basal ganglia: 84.0000% (minimum 99%, Missing); bone marrow: 66.8790% (minimum 99%, Missing); cerebellum: 78.9474% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); choroid plexus: 78.3582% (minimum 99%, Missing); colon: 74.4681% (minimum 97%, Missing); duodenum: 80.7692% (minimum 99%, Missing); esophagus: 68.6275% (minimum 97%, Missing); heart muscle: 82.6772% (minimum 99%, Missing); hippocampal formation: 84.6774% (minimum 99%, Missing); hypothalamus: 84.0000% (minimum 99%, Missing); kidney: 71.4286% (minimum 99%, Missing); liver: 81.3953% (minimum 99%, Missing); lung: 80.1527% (minimum 99%, Missing); lymph node: 70.0000% (minimum 97%, Missing); midbrain: 83.3333% (minimum 99%, Missing); pancreas: 77.2059% (minimum 99%, Missing); parathyroid gland: 75.5396% (minimum 97%, Missing); pituitary gland: 82.0312% (minimum 99%, Missing); rectum: 72.9167% (minimum 97%, Missing); retina: 59.6591% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 84.0000% (minimum 99%, Missing); skin: 76.0870% (minimum 95%, Missing); small intestine: 78.3582% (minimum 99%, Missing); smooth muscle: 72.9167% (minimum 99%, Missing); spinal cord: 81.3953% (minimum 99%, Missing); spleen: 79.5455% (minimum 95%, Missing); stomach: 76.6423% (minimum 97%, Missing); thymus: 70.0000% (minimum 95%, Missing); thyroid gland: 66.8790% (minimum 95%, Missing); tongue: 80.7692% (minimum 97%, Missing); urinary bladder: 82.0312% (minimum 97%, Missing)",-0.28121,-0.283725,-0.393409,0,5,partial,7.1,4.8,5.2,"retina: 7.1 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); esophagus: 4.8 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); duodenum: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138780,GSTCD,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.8790% (minimum 75%, Missing); esophagus: 68.6275% (minimum 70%, Missing); kidney: 71.4286% (minimum 75%, Missing); retina: 59.6591% (minimum 75%, Missing); smooth muscle: 72.9167% (minimum 75%, Missing)",0.0187898,-0.0137255,-0.153409,0,5,partial,7.1,4.8,5.2,"retina: 7.1 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); esophagus: 4.8 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); duodenum: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138780,GSTCD,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.8790% (minimum 75%, Missing); esophagus: 68.6275% (minimum 70%, Missing); kidney: 71.4286% (minimum 75%, Missing); retina: 59.6591% (minimum 75%, Missing); smooth muscle: 72.9167% (minimum 75%, Missing)",0.0187898,-0.0137255,-0.153409,0,5,partial,7.1,4.8,5.2,"retina: 7.1 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 5.2 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 3.9 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138780,GSTCD,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.8790% (minimum 75%, Missing); esophagus: 68.6275% (minimum 70%, Missing); kidney: 71.4286% (minimum 75%, Missing); retina: 59.6591% (minimum 75%, Missing); smooth muscle: 72.9167% (minimum 75%, Missing)",0.0187898,-0.0137255,-0.153409,0,5,partial,7.1,4.8,5.2,"retina: 7.1 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 5.2 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 3.9 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138780,GSTCD,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.8790% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.6275% (minimum 70%, Baseline (adaptation disabled)); kidney: 71.4286% (minimum 75%, Baseline (adaptation disabled)); retina: 59.6591% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.9167% (minimum 75%, Baseline (adaptation disabled))",0.0187898,-0.0137255,-0.153409,0,5,partial,7.1,4.8,5.2,"retina: 7.1 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 5.2 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 3.9 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138780,GSTCD,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138813,C4orf17,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138813,C4orf17,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138813,C4orf17,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138813,C4orf17,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138813,C4orf17,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138892,TTLL8,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138892,TTLL8,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138892,TTLL8,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138892,TTLL8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000138892,TTLL8,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 90%, Approved); adrenal gland: 55.9322% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 89.1892% (minimum 99%, Missing); bone marrow: 45.2055% (minimum 99%, Missing); cerebellum: 84.6154% (minimum 99%, Missing); cerebral cortex: 76.7442% (minimum 99%, Missing); choroid plexus: 86.8421% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 67.3469% (minimum 99%, Missing); esophagus: 61.1111% (minimum 97%, Missing); heart muscle: 76.7442% (minimum 99%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 89.1892% (minimum 99%, Missing); kidney: 64.7059% (minimum 99%, Missing); liver: 54.0984% (minimum 99%, Missing); lung: 64.7059% (minimum 99%, Missing); lymph node: 47.8261% (minimum 97%, Missing); midbrain: 91.6667% (minimum 99%, Missing); pancreas: 68.7500% (minimum 99%, Missing); parathyroid gland: 60.0000% (minimum 97%, Missing); pituitary gland: 84.6154% (minimum 99%, Missing); rectum: 63.4615% (minimum 97%, Missing); retina: 50.7692% (minimum 99%, Missing); salivary gland: 68.7500% (minimum 97%, Missing); skeletal muscle: 78.5714% (minimum 99%, Missing); skin: 63.4615% (minimum 95%, Missing); small intestine: 66.0000% (minimum 99%, Missing); smooth muscle: 61.1111% (minimum 99%, Missing); spinal cord: 89.1892% (minimum 99%, Missing); spleen: 54.0984% (minimum 95%, Missing); stomach: 63.4615% (minimum 97%, Missing); thymus: 48.5294% (minimum 95%, Missing); thyroid gland: 55.0000% (minimum 95%, Missing); tongue: 73.3333% (minimum 97%, Missing); urinary bladder: 73.3333% (minimum 97%, Missing)",-0.464706,-0.491739,-0.537945,0,1,partial,4,3.6,3.5,"bone marrow: 4 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); esophagus: 2.1 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139133,ALG10,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.9322% (minimum 75%, Missing); bone marrow: 45.2055% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 67.3469% (minimum 75%, Missing); esophagus: 61.1111% (minimum 70%, Missing); kidney: 64.7059% (minimum 75%, Missing); liver: 54.0984% (minimum 75%, Missing); lung: 64.7059% (minimum 75%, Missing); lymph node: 47.8261% (minimum 70%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); rectum: 63.4615% (minimum 70%, Missing); retina: 50.7692% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skin: 63.4615% (minimum 65%, Missing); small intestine: 66.0000% (minimum 75%, Missing); smooth muscle: 61.1111% (minimum 75%, Missing); spleen: 54.0984% (minimum 65%, Missing); stomach: 63.4615% (minimum 70%, Missing); thymus: 48.5294% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing)",-0.164706,-0.221739,-0.297945,0,1,partial,4,3.6,3.5,"bone marrow: 4 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); esophagus: 2.1 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139133,ALG10,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.9322% (minimum 75%, Missing); bone marrow: 45.2055% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 67.3469% (minimum 75%, Missing); esophagus: 61.1111% (minimum 70%, Missing); kidney: 64.7059% (minimum 75%, Missing); liver: 54.0984% (minimum 75%, Missing); lung: 64.7059% (minimum 75%, Missing); lymph node: 47.8261% (minimum 70%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); rectum: 63.4615% (minimum 70%, Missing); retina: 50.7692% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skin: 63.4615% (minimum 65%, Missing); small intestine: 66.0000% (minimum 75%, Missing); smooth muscle: 61.1111% (minimum 75%, Missing); spleen: 54.0984% (minimum 65%, Missing); stomach: 63.4615% (minimum 70%, Missing); thymus: 48.5294% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing)",-0.164706,-0.221739,-0.297945,0,1,partial,4,3.6,3.5,"bone marrow: 4 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139133,ALG10,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.9322% (minimum 75%, Missing); bone marrow: 45.2055% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 67.3469% (minimum 75%, Missing); esophagus: 61.1111% (minimum 70%, Missing); kidney: 64.7059% (minimum 75%, Missing); liver: 54.0984% (minimum 75%, Missing); lung: 64.7059% (minimum 75%, Missing); lymph node: 47.8261% (minimum 70%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); rectum: 63.4615% (minimum 70%, Missing); retina: 50.7692% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skin: 63.4615% (minimum 65%, Missing); small intestine: 66.0000% (minimum 75%, Missing); smooth muscle: 61.1111% (minimum 75%, Missing); spleen: 54.0984% (minimum 65%, Missing); stomach: 63.4615% (minimum 70%, Missing); thymus: 48.5294% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing)",-0.164706,-0.221739,-0.297945,0,1,partial,4,3.6,3.5,"bone marrow: 4 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139133,ALG10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 55.9322% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 45.2055% (minimum 75%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 67.3469% (minimum 75%, Baseline (adaptation disabled)); esophagus: 61.1111% (minimum 70%, Baseline (adaptation disabled)); kidney: 64.7059% (minimum 75%, Baseline (adaptation disabled)); liver: 54.0984% (minimum 75%, Baseline (adaptation disabled)); lung: 64.7059% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.8261% (minimum 70%, Baseline (adaptation disabled)); pancreas: 68.7500% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); rectum: 63.4615% (minimum 70%, Baseline (adaptation disabled)); retina: 50.7692% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.7500% (minimum 70%, Baseline (adaptation disabled)); skin: 63.4615% (minimum 65%, Baseline (adaptation disabled)); small intestine: 66.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.1111% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.0984% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.4615% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.5294% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.0000% (minimum 65%, Baseline (adaptation disabled))",-0.164706,-0.221739,-0.297945,0,1,partial,4,3.6,3.5,"bone marrow: 4 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139133,ALG10,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0102804,0.0203614,0.000361446,0,80,unavailable,0.4,0.4,1.7,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139151,PLCZ1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31028,0.290361,0.240361,0,80,unavailable,0.4,0.4,1.7,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139151,PLCZ1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31028,0.290361,0.240361,0,80,unavailable,0.4,0.4,1.7,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139151,PLCZ1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31028,0.290361,0.240361,0,80,unavailable,0.4,0.4,1.7,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139151,PLCZ1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31028,0.290361,0.240361,0,80,unavailable,0.4,0.4,1.7,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139151,PLCZ1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.9189% (minimum 95%, Uncertain); adrenal gland: 57.9545% (minimum 99%, Missing); amygdala: 71.8310% (minimum 99%, Missing); basal ganglia: 68.0000% (minimum 99%, Missing); bone marrow: 69.8630% (minimum 99%, Uncertain); cerebellum: 65.3846% (minimum 99%, Missing); cerebral cortex: 68.9189% (minimum 99%, Missing); choroid plexus: 65.3846% (minimum 99%, Missing); colon: 68.9189% (minimum 97%, Missing); duodenum: 64.5570% (minimum 99%, Missing); esophagus: 68.9189% (minimum 97%, Missing); heart muscle: 59.3023% (minimum 99%, Missing); hippocampal formation: 71.8310% (minimum 99%, Missing); hypothalamus: 71.8310% (minimum 99%, Missing); kidney: 46.3636% (minimum 99%, Missing); liver: 35.1724% (minimum 99%, Missing); lung: 71.8310% (minimum 99%, Missing); lymph node: 76.1194% (minimum 97%, Uncertain); midbrain: 71.8310% (minimum 99%, Missing); pancreas: 60.7143% (minimum 99%, Missing); parathyroid gland: 52.5773% (minimum 97%, Missing); pituitary gland: 67.1053% (minimum 99%, Missing); rectum: 68.0000% (minimum 97%, Missing); retina: 46.3636% (minimum 99%, Missing); salivary gland: 69.8630% (minimum 97%, Missing); skeletal muscle: 41.1290% (minimum 99%, Missing); skin: 68.9189% (minimum 95%, Missing); small intestine: 71.8310% (minimum 99%, Missing); smooth muscle: 63.7500% (minimum 99%, Uncertain); spinal cord: 68.9189% (minimum 99%, Missing); spleen: 68.0000% (minimum 95%, Uncertain); stomach: 66.2338% (minimum 97%, Missing); thymus: 85.0000% (minimum 95%, Missing); thyroid gland: 59.3023% (minimum 95%, Missing); tongue: 40.4762% (minimum 97%, Missing); urinary bladder: 71.8310% (minimum 97%, Missing)",-0.356977,-0.565238,-0.638276,0,2,partial,9.4,7.5,3.5,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 2); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139160,ETFBKMT,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.9545% (minimum 75%, Missing); amygdala: 71.8310% (minimum 75%, Missing); basal ganglia: 68.0000% (minimum 75%, Missing); bone marrow: 69.8630% (minimum 75%, Uncertain); cerebellum: 65.3846% (minimum 75%, Missing); cerebral cortex: 68.9189% (minimum 75%, Missing); choroid plexus: 65.3846% (minimum 75%, Missing); colon: 68.9189% (minimum 70%, Missing); duodenum: 64.5570% (minimum 75%, Missing); esophagus: 68.9189% (minimum 70%, Missing); heart muscle: 59.3023% (minimum 75%, Missing); hippocampal formation: 71.8310% (minimum 75%, Missing); hypothalamus: 71.8310% (minimum 75%, Missing); kidney: 46.3636% (minimum 75%, Missing); liver: 35.1724% (minimum 75%, Missing); lung: 71.8310% (minimum 75%, Missing); midbrain: 71.8310% (minimum 75%, Missing); pancreas: 60.7143% (minimum 75%, Missing); parathyroid gland: 52.5773% (minimum 70%, Missing); pituitary gland: 67.1053% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 46.3636% (minimum 75%, Missing); salivary gland: 69.8630% (minimum 70%, Missing); skeletal muscle: 41.1290% (minimum 75%, Missing); small intestine: 71.8310% (minimum 75%, Missing); smooth muscle: 63.7500% (minimum 75%, Uncertain); spinal cord: 68.9189% (minimum 75%, Missing); stomach: 66.2338% (minimum 70%, Missing); thyroid gland: 59.3023% (minimum 65%, Missing); tongue: 40.4762% (minimum 70%, Missing)",-0.0569767,-0.295238,-0.398276,0,2,partial,9.4,7.5,3.5,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 2); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139160,ETFBKMT,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.9545% (minimum 75%, Missing); amygdala: 71.8310% (minimum 75%, Missing); basal ganglia: 68.0000% (minimum 75%, Missing); bone marrow: 69.8630% (minimum 75%, Uncertain); cerebellum: 65.3846% (minimum 75%, Missing); cerebral cortex: 68.9189% (minimum 75%, Missing); choroid plexus: 65.3846% (minimum 75%, Missing); colon: 68.9189% (minimum 70%, Missing); duodenum: 64.5570% (minimum 75%, Missing); esophagus: 68.9189% (minimum 70%, Missing); heart muscle: 59.3023% (minimum 75%, Missing); hippocampal formation: 71.8310% (minimum 75%, Missing); hypothalamus: 71.8310% (minimum 75%, Missing); kidney: 46.3636% (minimum 75%, Missing); liver: 35.1724% (minimum 75%, Missing); lung: 71.8310% (minimum 75%, Missing); midbrain: 71.8310% (minimum 75%, Missing); pancreas: 60.7143% (minimum 75%, Missing); parathyroid gland: 52.5773% (minimum 70%, Missing); pituitary gland: 67.1053% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 46.3636% (minimum 75%, Missing); salivary gland: 69.8630% (minimum 70%, Missing); skeletal muscle: 41.1290% (minimum 75%, Missing); small intestine: 71.8310% (minimum 75%, Missing); smooth muscle: 63.7500% (minimum 75%, Uncertain); spinal cord: 68.9189% (minimum 75%, Missing); stomach: 66.2338% (minimum 70%, Missing); thyroid gland: 59.3023% (minimum 65%, Missing); tongue: 40.4762% (minimum 70%, Missing)",-0.0569767,-0.295238,-0.398276,0,2,partial,9.4,7.5,3.5,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 3); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139160,ETFBKMT,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.9545% (minimum 75%, Missing); amygdala: 71.8310% (minimum 75%, Missing); basal ganglia: 68.0000% (minimum 75%, Missing); bone marrow: 69.8630% (minimum 75%, Uncertain); cerebellum: 65.3846% (minimum 75%, Missing); cerebral cortex: 68.9189% (minimum 75%, Missing); choroid plexus: 65.3846% (minimum 75%, Missing); colon: 68.9189% (minimum 70%, Missing); duodenum: 64.5570% (minimum 75%, Missing); esophagus: 68.9189% (minimum 70%, Missing); heart muscle: 59.3023% (minimum 75%, Missing); hippocampal formation: 71.8310% (minimum 75%, Missing); hypothalamus: 71.8310% (minimum 75%, Missing); kidney: 46.3636% (minimum 75%, Missing); liver: 35.1724% (minimum 75%, Missing); lung: 71.8310% (minimum 75%, Missing); midbrain: 71.8310% (minimum 75%, Missing); pancreas: 60.7143% (minimum 75%, Missing); parathyroid gland: 52.5773% (minimum 70%, Missing); pituitary gland: 67.1053% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 46.3636% (minimum 75%, Missing); salivary gland: 69.8630% (minimum 70%, Missing); skeletal muscle: 41.1290% (minimum 75%, Missing); small intestine: 71.8310% (minimum 75%, Missing); smooth muscle: 63.7500% (minimum 75%, Uncertain); spinal cord: 68.9189% (minimum 75%, Missing); stomach: 66.2338% (minimum 70%, Missing); thyroid gland: 59.3023% (minimum 65%, Missing); tongue: 40.4762% (minimum 70%, Missing)",-0.0569767,-0.295238,-0.398276,0,2,partial,9.4,7.5,3.5,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 3); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139160,ETFBKMT,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.9545% (minimum 75%, Baseline (adaptation disabled)); amygdala: 71.8310% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 68.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 69.8630% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.3846% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.9189% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 65.3846% (minimum 75%, Baseline (adaptation disabled)); colon: 68.9189% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.5570% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.9189% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.3023% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.8310% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.8310% (minimum 75%, Baseline (adaptation disabled)); kidney: 46.3636% (minimum 75%, Baseline (adaptation disabled)); liver: 35.1724% (minimum 75%, Baseline (adaptation disabled)); lung: 71.8310% (minimum 75%, Baseline (adaptation disabled)); midbrain: 71.8310% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.7143% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.5773% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.1053% (minimum 75%, Baseline (adaptation disabled)); rectum: 68.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 46.3636% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 69.8630% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 41.1290% (minimum 75%, Baseline (adaptation disabled)); small intestine: 71.8310% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.7500% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.9189% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.2338% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 59.3023% (minimum 65%, Baseline (adaptation disabled)); tongue: 40.4762% (minimum 70%, Baseline (adaptation disabled))",-0.0569767,-0.295238,-0.398276,0,2,partial,9.4,7.5,3.5,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 3); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139160,ETFBKMT,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.0900% (minimum 95%, Missing); adrenal gland: 57.7039% (minimum 99%, Missing); amygdala: 67.7305% (minimum 99%, Missing); basal ganglia: 67.0175% (minimum 99%, Missing); bone marrow: 61.4148% (minimum 98%, Approved); cerebellum: 61.4148% (minimum 99%, Missing); cerebral cortex: 53.8028% (minimum 99%, Missing); choroid plexus: 72.9008% (minimum 99%, Missing); colon: 42.0705% (minimum 97%, Missing); duodenum: 45.6938% (minimum 99%, Missing); esophagus: 64.5270% (minimum 97%, Missing); heart muscle: 72.9008% (minimum 99%, Missing); hippocampal formation: 67.0175% (minimum 99%, Missing); hypothalamus: 56.8452% (minimum 99%, Missing); kidney: 51.7615% (minimum 99%, Missing); liver: 51.9022% (minimum 99%, Missing); lung: 61.0224% (minimum 99%, Missing); lymph node: 52.9086% (minimum 97%, Missing); midbrain: 65.8621% (minimum 99%, Missing); pancreas: 64.7458% (minimum 99%, Missing); parathyroid gland: 64.5270% (minimum 95%, Approved); pituitary gland: 58.9506% (minimum 99%, Missing); rectum: 56.1765% (minimum 97%, Missing); retina: 52.0436% (minimum 99%, Missing); salivary gland: 61.2179% (minimum 97%, Missing); skeletal muscle: 76.0956% (minimum 99%, Missing); skin: 56.1765% (minimum 95%, Missing); small intestine: 56.0117% (minimum 99%, Missing); smooth muscle: 72.3485% (minimum 98%, Approved); spinal cord: 63.2450% (minimum 99%, Missing); spleen: 53.9548% (minimum 90%, Approved); stomach: 30.3175% (minimum 97%, Missing); thymus: 45.9135% (minimum 95%, Missing); thyroid gland: 57.5301% (minimum 95%, Missing); tongue: 77.9592% (minimum 97%, Missing); urinary bladder: 64.7458% (minimum 97%, Missing)",-0.490865,-0.666825,-0.533062,0,4,partial,22.7,43.9,22.5,"stomach: 43.9 nTPM (protected, limit 2); colon: 26.3 nTPM (protected, limit 2); duodenum: 22.7 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 2); cerebral cortex: 16.4 nTPM (vital, limit 1); spleen: 16.3 nTPM (manageable, limit 10); small intestine: 15 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); rectum: 14.9 nTPM (protected, limit 2); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (manageable, limit 5); adrenal gland: 14 nTPM (vital, limit 1); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 2); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 2); spinal cord: 11.1 nTPM (vital, limit 1); esophagus: 10.5 nTPM (protected, limit 2); parathyroid gland: 10.5 nTPM (protected, limit 4); pancreas: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (manageable, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 2); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139163,ETNK1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.7039% (minimum 75%, Missing); amygdala: 67.7305% (minimum 75%, Missing); basal ganglia: 67.0175% (minimum 75%, Missing); bone marrow: 61.4148% (minimum 70%, Approved); cerebellum: 61.4148% (minimum 75%, Missing); cerebral cortex: 53.8028% (minimum 75%, Missing); choroid plexus: 72.9008% (minimum 75%, Missing); colon: 42.0705% (minimum 70%, Missing); duodenum: 45.6938% (minimum 75%, Missing); esophagus: 64.5270% (minimum 70%, Missing); heart muscle: 72.9008% (minimum 75%, Missing); hippocampal formation: 67.0175% (minimum 75%, Missing); hypothalamus: 56.8452% (minimum 75%, Missing); kidney: 51.7615% (minimum 75%, Missing); liver: 51.9022% (minimum 75%, Missing); lung: 61.0224% (minimum 75%, Missing); lymph node: 52.9086% (minimum 70%, Missing); midbrain: 65.8621% (minimum 75%, Missing); pancreas: 64.7458% (minimum 75%, Missing); parathyroid gland: 64.5270% (minimum 65%, Approved); pituitary gland: 58.9506% (minimum 75%, Missing); rectum: 56.1765% (minimum 70%, Missing); retina: 52.0436% (minimum 75%, Missing); salivary gland: 61.2179% (minimum 70%, Missing); skin: 56.1765% (minimum 65%, Missing); small intestine: 56.0117% (minimum 75%, Missing); spinal cord: 63.2450% (minimum 75%, Missing); spleen: 53.9548% (minimum 60%, Approved); stomach: 30.3175% (minimum 70%, Missing); thymus: 45.9135% (minimum 65%, Missing); thyroid gland: 57.5301% (minimum 65%, Missing); urinary bladder: 64.7458% (minimum 70%, Missing)",-0.190865,-0.396825,-0.293062,0,4,partial,22.7,43.9,22.5,"stomach: 43.9 nTPM (protected, limit 2); colon: 26.3 nTPM (protected, limit 2); duodenum: 22.7 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 2); cerebral cortex: 16.4 nTPM (vital, limit 1); spleen: 16.3 nTPM (manageable, limit 10); small intestine: 15 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); rectum: 14.9 nTPM (protected, limit 2); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (manageable, limit 5); adrenal gland: 14 nTPM (vital, limit 1); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 2); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 2); spinal cord: 11.1 nTPM (vital, limit 1); esophagus: 10.5 nTPM (protected, limit 2); parathyroid gland: 10.5 nTPM (protected, limit 4); pancreas: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (manageable, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 2); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139163,ETNK1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.7039% (minimum 75%, Missing); amygdala: 67.7305% (minimum 75%, Missing); basal ganglia: 67.0175% (minimum 75%, Missing); bone marrow: 61.4148% (minimum 70%, Approved); cerebellum: 61.4148% (minimum 75%, Missing); cerebral cortex: 53.8028% (minimum 75%, Missing); choroid plexus: 72.9008% (minimum 75%, Missing); colon: 42.0705% (minimum 70%, Missing); duodenum: 45.6938% (minimum 75%, Missing); esophagus: 64.5270% (minimum 70%, Missing); heart muscle: 72.9008% (minimum 75%, Missing); hippocampal formation: 67.0175% (minimum 75%, Missing); hypothalamus: 56.8452% (minimum 75%, Missing); kidney: 51.7615% (minimum 75%, Missing); liver: 51.9022% (minimum 75%, Missing); lung: 61.0224% (minimum 75%, Missing); lymph node: 52.9086% (minimum 70%, Missing); midbrain: 65.8621% (minimum 75%, Missing); pancreas: 64.7458% (minimum 75%, Missing); parathyroid gland: 64.5270% (minimum 65%, Approved); pituitary gland: 58.9506% (minimum 75%, Missing); rectum: 56.1765% (minimum 70%, Missing); retina: 52.0436% (minimum 75%, Missing); salivary gland: 61.2179% (minimum 70%, Missing); skin: 56.1765% (minimum 65%, Missing); small intestine: 56.0117% (minimum 75%, Missing); spinal cord: 63.2450% (minimum 75%, Missing); spleen: 53.9548% (minimum 60%, Approved); stomach: 30.3175% (minimum 70%, Missing); thymus: 45.9135% (minimum 65%, Missing); thyroid gland: 57.5301% (minimum 65%, Missing); urinary bladder: 64.7458% (minimum 70%, Missing)",-0.190865,-0.396825,-0.293062,0,4,partial,22.7,43.9,22.5,"stomach: 43.9 nTPM (protected, limit 3); colon: 26.3 nTPM (protected, limit 3); duodenum: 22.7 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 3); cerebral cortex: 16.4 nTPM (vital, limit 1); spleen: 16.3 nTPM (manageable, limit 10); small intestine: 15 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); rectum: 14.9 nTPM (protected, limit 3); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (manageable, limit 5); adrenal gland: 14 nTPM (vital, limit 1); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 3); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 2); spinal cord: 11.1 nTPM (vital, limit 1); esophagus: 10.5 nTPM (protected, limit 3); parathyroid gland: 10.5 nTPM (protected, limit 4); pancreas: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (manageable, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 2); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139163,ETNK1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.7039% (minimum 75%, Missing); amygdala: 67.7305% (minimum 75%, Missing); basal ganglia: 67.0175% (minimum 75%, Missing); bone marrow: 61.4148% (minimum 70%, Approved); cerebellum: 61.4148% (minimum 75%, Missing); cerebral cortex: 53.8028% (minimum 75%, Missing); choroid plexus: 72.9008% (minimum 75%, Missing); colon: 42.0705% (minimum 70%, Missing); duodenum: 45.6938% (minimum 75%, Missing); esophagus: 64.5270% (minimum 70%, Missing); heart muscle: 72.9008% (minimum 75%, Missing); hippocampal formation: 67.0175% (minimum 75%, Missing); hypothalamus: 56.8452% (minimum 75%, Missing); kidney: 51.7615% (minimum 75%, Missing); liver: 51.9022% (minimum 75%, Missing); lung: 61.0224% (minimum 75%, Missing); lymph node: 52.9086% (minimum 70%, Missing); midbrain: 65.8621% (minimum 75%, Missing); pancreas: 64.7458% (minimum 75%, Missing); parathyroid gland: 64.5270% (minimum 65%, Approved); pituitary gland: 58.9506% (minimum 75%, Missing); rectum: 56.1765% (minimum 70%, Missing); retina: 52.0436% (minimum 75%, Missing); salivary gland: 61.2179% (minimum 70%, Missing); skin: 56.1765% (minimum 65%, Missing); small intestine: 56.0117% (minimum 75%, Missing); spinal cord: 63.2450% (minimum 75%, Missing); spleen: 53.9548% (minimum 60%, Approved); stomach: 30.3175% (minimum 70%, Missing); thymus: 45.9135% (minimum 65%, Missing); thyroid gland: 57.5301% (minimum 65%, Missing); urinary bladder: 64.7458% (minimum 70%, Missing)",-0.190865,-0.396825,-0.293062,0,4,partial,22.7,43.9,22.5,"stomach: 43.9 nTPM (protected, limit 3); colon: 26.3 nTPM (protected, limit 3); duodenum: 22.7 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 3); cerebral cortex: 16.4 nTPM (vital, limit 1); spleen: 16.3 nTPM (manageable, limit 10); small intestine: 15 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); rectum: 14.9 nTPM (protected, limit 3); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (manageable, limit 5); adrenal gland: 14 nTPM (vital, limit 1); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 3); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 2); spinal cord: 11.1 nTPM (vital, limit 1); esophagus: 10.5 nTPM (protected, limit 3); parathyroid gland: 10.5 nTPM (protected, limit 4); pancreas: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (manageable, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 2); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139163,ETNK1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.7039% (minimum 75%, Baseline (adaptation disabled)); amygdala: 67.7305% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 67.0175% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.4148% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.4148% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.8028% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.9008% (minimum 75%, Baseline (adaptation disabled)); colon: 42.0705% (minimum 70%, Baseline (adaptation disabled)); duodenum: 45.6938% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.5270% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 72.9008% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.0175% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 56.8452% (minimum 75%, Baseline (adaptation disabled)); kidney: 51.7615% (minimum 75%, Baseline (adaptation disabled)); liver: 51.9022% (minimum 75%, Baseline (adaptation disabled)); lung: 61.0224% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.9086% (minimum 70%, Baseline (adaptation disabled)); midbrain: 65.8621% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.7458% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.5270% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.9506% (minimum 75%, Baseline (adaptation disabled)); rectum: 56.1765% (minimum 70%, Baseline (adaptation disabled)); retina: 52.0436% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.2179% (minimum 70%, Baseline (adaptation disabled)); skin: 56.1765% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.0117% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.3485% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.2450% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.9548% (minimum 65%, Baseline (adaptation disabled)); stomach: 30.3175% (minimum 70%, Baseline (adaptation disabled)); thymus: 45.9135% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.5301% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 64.7458% (minimum 70%, Baseline (adaptation disabled))",-0.190865,-0.396825,-0.293062,0,4,partial,22.7,43.9,22.5,"stomach: 43.9 nTPM (protected, limit 3); colon: 26.3 nTPM (protected, limit 3); duodenum: 22.7 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 3); cerebral cortex: 16.4 nTPM (vital, limit 1); spleen: 16.3 nTPM (manageable, limit 5); small intestine: 15 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); rectum: 14.9 nTPM (protected, limit 3); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (manageable, limit 5); adrenal gland: 14 nTPM (vital, limit 1); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 3); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); esophagus: 10.5 nTPM (protected, limit 3); parathyroid gland: 10.5 nTPM (protected, limit 3); pancreas: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (manageable, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139163,ETNK1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.6140% (minimum 95%, Missing); basal ganglia: 86.6667% (minimum 99%, Missing); cerebral cortex: 96.2963% (minimum 99%, Missing); colon: 96.2963% (minimum 97%, Missing); esophagus: 96.2963% (minimum 97%, Missing); heart muscle: 70.2703% (minimum 99%, Missing); hippocampal formation: 96.2963% (minimum 99%, Missing); hypothalamus: 92.8571% (minimum 99%, Missing); kidney: 27.3684% (minimum 99%, Missing); lung: 54.1667% (minimum 99%, Missing); lymph node: 74.2857% (minimum 97%, Missing); pancreas: 89.6552% (minimum 99%, Missing); parathyroid gland: 96.2963% (minimum 97%, Missing); pituitary gland: 96.2963% (minimum 99%, Missing); retina: 78.7879% (minimum 99%, Missing); salivary gland: 96.2963% (minimum 97%, Missing); skeletal muscle: 92.8571% (minimum 99%, Missing); stomach: 96.2963% (minimum 97%, Missing); thymus: 92.8571% (minimum 95%, Missing); thyroid gland: 48.1481% (minimum 95%, Missing); urinary bladder: 40.0000% (minimum 97%, Missing)",-0.49386,-0.57,-0.716316,0,80,unavailable,6.9,3.9,3.1,"kidney: 6.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139304,PTPRQ,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.6140% (minimum 65%, Missing); heart muscle: 70.2703% (minimum 75%, Missing); kidney: 27.3684% (minimum 75%, Missing); lung: 54.1667% (minimum 75%, Missing); thyroid gland: 48.1481% (minimum 65%, Missing); urinary bladder: 40.0000% (minimum 70%, Missing)",-0.19386,-0.3,-0.476316,0,80,unavailable,6.9,3.9,3.1,"kidney: 6.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139304,PTPRQ,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.6140% (minimum 65%, Missing); heart muscle: 70.2703% (minimum 75%, Missing); kidney: 27.3684% (minimum 75%, Missing); lung: 54.1667% (minimum 75%, Missing); thyroid gland: 48.1481% (minimum 65%, Missing); urinary bladder: 40.0000% (minimum 70%, Missing)",-0.19386,-0.3,-0.476316,0,80,unavailable,6.9,3.9,3.1,"kidney: 6.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139304,PTPRQ,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.6140% (minimum 65%, Missing); heart muscle: 70.2703% (minimum 75%, Missing); kidney: 27.3684% (minimum 75%, Missing); lung: 54.1667% (minimum 75%, Missing); thyroid gland: 48.1481% (minimum 65%, Missing); urinary bladder: 40.0000% (minimum 70%, Missing)",-0.19386,-0.3,-0.476316,0,80,unavailable,6.9,3.9,3.1,"kidney: 6.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139304,PTPRQ,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.6140% (minimum 65%, Baseline (adaptation disabled)); heart muscle: 70.2703% (minimum 75%, Baseline (adaptation disabled)); kidney: 27.3684% (minimum 75%, Baseline (adaptation disabled)); lung: 54.1667% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 48.1481% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 40.0000% (minimum 70%, Baseline (adaptation disabled))",-0.19386,-0.3,-0.476316,0,80,unavailable,6.9,3.9,3.1,"kidney: 6.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139304,PTPRQ,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.2397% (minimum 95%, Missing); adrenal gland: 80.3509% (minimum 99%, Missing); amygdala: 90.1575% (minimum 99%, Missing); basal ganglia: 89.4531% (minimum 99%, Missing); bone marrow: 60.2632% (minimum 99%, Missing); cerebellum: 95.4167% (minimum 99%, Missing); cerebral cortex: 87.0722% (minimum 99%, Missing); choroid plexus: 85.4478% (minimum 99%, Missing); colon: 74.1100% (minimum 97%, Missing); duodenum: 76.8456% (minimum 99%, Missing); esophagus: 70.2454% (minimum 97%, Missing); heart muscle: 72.0126% (minimum 99%, Missing); hippocampal formation: 89.4531% (minimum 99%, Missing); hypothalamus: 90.5138% (minimum 99%, Missing); kidney: 72.6984% (minimum 99%, Missing); liver: 78.9655% (minimum 99%, Missing); lung: 72.9299% (minimum 99%, Missing); lymph node: 60.4222% (minimum 97%, Missing); midbrain: 89.8039% (minimum 99%, Missing); pancreas: 76.8456% (minimum 99%, Missing); parathyroid gland: 61.3941% (minimum 97%, Missing); pituitary gland: 86.0902% (minimum 99%, Missing); rectum: 70.8978% (minimum 97%, Missing); retina: 76.5886% (minimum 99%, Missing); salivary gland: 77.6271% (minimum 97%, Missing); skeletal muscle: 38.4228% (minimum 99%, Missing); skin: 74.1100% (minimum 95%, Missing); small intestine: 77.3649% (minimum 99%, Missing); smooth muscle: 64.5070% (minimum 99%, Missing); spinal cord: 86.7424% (minimum 99%, Missing); spleen: 63.7883% (minimum 95%, Missing); stomach: 76.5886% (minimum 97%, Missing); thymus: 51.1161% (minimum 95%, Missing); thyroid gland: 69.1843% (minimum 95%, Missing); tongue: 48.2105% (minimum 97%, Missing); urinary bladder: 71.3396% (minimum 97%, Missing)",-0.438839,-0.487895,-0.605772,0,2,partial,36.7,24.6,21.9,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 2); thymus: 21.9 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 2); parathyroid gland: 14.4 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 2); rectum: 9.4 nTPM (protected, limit 2); urinary bladder: 9.2 nTPM (protected, limit 2); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); retina: 7 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); duodenum: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139350,NEDD1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 60.2632% (minimum 75%, Missing); heart muscle: 72.0126% (minimum 75%, Missing); kidney: 72.6984% (minimum 75%, Missing); lung: 72.9299% (minimum 75%, Missing); lymph node: 60.4222% (minimum 70%, Missing); parathyroid gland: 61.3941% (minimum 70%, Missing); skeletal muscle: 38.4228% (minimum 75%, Missing); smooth muscle: 64.5070% (minimum 75%, Missing); spleen: 63.7883% (minimum 65%, Missing); thymus: 51.1161% (minimum 65%, Missing); tongue: 48.2105% (minimum 70%, Missing)",-0.138839,-0.217895,-0.365772,0,2,partial,36.7,24.6,21.9,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 2); thymus: 21.9 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 2); parathyroid gland: 14.4 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 2); rectum: 9.4 nTPM (protected, limit 2); urinary bladder: 9.2 nTPM (protected, limit 2); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); retina: 7 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); duodenum: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139350,NEDD1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 60.2632% (minimum 75%, Missing); heart muscle: 72.0126% (minimum 75%, Missing); kidney: 72.6984% (minimum 75%, Missing); lung: 72.9299% (minimum 75%, Missing); lymph node: 60.4222% (minimum 70%, Missing); parathyroid gland: 61.3941% (minimum 70%, Missing); skeletal muscle: 38.4228% (minimum 75%, Missing); smooth muscle: 64.5070% (minimum 75%, Missing); spleen: 63.7883% (minimum 65%, Missing); thymus: 51.1161% (minimum 65%, Missing); tongue: 48.2105% (minimum 70%, Missing)",-0.138839,-0.217895,-0.365772,0,2,partial,36.7,24.6,21.9,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 3); thymus: 21.9 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 3); parathyroid gland: 14.4 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 3); rectum: 9.4 nTPM (protected, limit 3); urinary bladder: 9.2 nTPM (protected, limit 3); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); retina: 7 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); duodenum: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139350,NEDD1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 60.2632% (minimum 75%, Missing); heart muscle: 72.0126% (minimum 75%, Missing); kidney: 72.6984% (minimum 75%, Missing); lung: 72.9299% (minimum 75%, Missing); lymph node: 60.4222% (minimum 70%, Missing); parathyroid gland: 61.3941% (minimum 70%, Missing); skeletal muscle: 38.4228% (minimum 75%, Missing); smooth muscle: 64.5070% (minimum 75%, Missing); spleen: 63.7883% (minimum 65%, Missing); thymus: 51.1161% (minimum 65%, Missing); tongue: 48.2105% (minimum 70%, Missing)",-0.138839,-0.217895,-0.365772,0,2,partial,36.7,24.6,21.9,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 3); thymus: 21.9 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 3); parathyroid gland: 14.4 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 3); rectum: 9.4 nTPM (protected, limit 3); urinary bladder: 9.2 nTPM (protected, limit 3); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); retina: 7 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); duodenum: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139350,NEDD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 60.2632% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 72.0126% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.6984% (minimum 75%, Baseline (adaptation disabled)); lung: 72.9299% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.4222% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 61.3941% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 38.4228% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.5070% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.7883% (minimum 65%, Baseline (adaptation disabled)); thymus: 51.1161% (minimum 65%, Baseline (adaptation disabled)); tongue: 48.2105% (minimum 70%, Baseline (adaptation disabled))",-0.138839,-0.217895,-0.365772,0,2,partial,36.7,24.6,21.9,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 3); thymus: 21.9 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 3); parathyroid gland: 14.4 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 3); rectum: 9.4 nTPM (protected, limit 3); urinary bladder: 9.2 nTPM (protected, limit 3); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); retina: 7 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); duodenum: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139350,NEDD1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.0487593,0.03,0.00875931,0,1,partial,0.7,0.5,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139351,SYCP3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348759,0.3,0.248759,0,1,partial,0.7,0.5,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139351,SYCP3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348759,0.3,0.248759,0,1,partial,0.7,0.5,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139351,SYCP3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348759,0.3,0.248759,0,1,partial,0.7,0.5,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139351,SYCP3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347522,0.293827,0.241379,0,1,partial,0.7,0.5,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139351,SYCP3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.2301% (minimum 99%, Missing); choroid plexus: 95.6897% (minimum 99%, Missing); kidney: 98.2301% (minimum 99%, Missing); liver: 93.2773% (minimum 99%, Missing); pituitary gland: 98.2301% (minimum 99%, Missing); retina: 96.5217% (minimum 99%, Missing); skeletal muscle: 98.2301% (minimum 99%, Missing)",0.0236842,0.00368421,-0.0572269,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139445,FOXN4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.323684,0.273684,0.182773,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139445,FOXN4,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.323684,0.273684,0.182773,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139445,FOXN4,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.323684,0.273684,0.182773,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139445,FOXN4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.323684,0.273684,0.182773,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139445,FOXN4,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.5618% (minimum 90%, Approved); adrenal gland: 79.3852% (minimum 98%, Approved); amygdala: 81.1460% (minimum 99%, Missing); basal ganglia: 79.9636% (minimum 99%, Missing); bone marrow: 69.5721% (minimum 98%, Approved); cerebellum: 73.0449% (minimum 99%, Missing); cerebral cortex: 75.8204% (minimum 99%, Missing); choroid plexus: 91.2682% (minimum 99%, Missing); colon: 80.4029% (minimum 97%, Missing); duodenum: 79.8182% (minimum 99%, Missing); esophagus: 77.9751% (minimum 97%, Missing); heart muscle: 77.0175% (minimum 99%, Missing); hippocampal formation: 80.1095% (minimum 99%, Missing); hypothalamus: 77.6991% (minimum 99%, Missing); kidney: 75.8204% (minimum 99%, Missing); liver: 76.2153% (minimum 99%, Missing); lung: 72.2039% (minimum 99%, Missing); lymph node: 68.9168% (minimum 97%, Missing); midbrain: 81.5985% (minimum 99%, Missing); pancreas: 80.6985% (minimum 99%, Missing); parathyroid gland: 81.9030% (minimum 97%, Missing); pituitary gland: 68.3801% (minimum 99%, Missing); rectum: 77.9751% (minimum 97%, Missing); retina: 63.3478% (minimum 99%, Missing); salivary gland: 80.8471% (minimum 97%, Missing); skeletal muscle: 70.0159% (minimum 98%, Approved); skin: 79.5290% (minimum 95%, Missing); small intestine: 80.2559% (minimum 99%, Missing); smooth muscle: 78.1139% (minimum 99%, Missing); spinal cord: 80.1095% (minimum 99%, Missing); spleen: 79.5290% (minimum 95%, Missing); stomach: 78.8151% (minimum 97%, Missing); thymus: 62.9842% (minimum 95%, Missing); thyroid gland: 70.5788% (minimum 95%, Missing); tongue: 66.1145% (minimum 97%, Missing); urinary bladder: 71.0356% (minimum 97%, Missing)",-0.320158,-0.308855,-0.356522,0,7,partial,25.4,22.5,25.8,"thymus: 25.8 nTPM (manageable, limit 5); retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 2); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 2); bone marrow: 19.2 nTPM (vital, limit 2); skeletal muscle: 18.8 nTPM (vital, limit 2); thyroid gland: 18.3 nTPM (manageable, limit 5); urinary bladder: 17.9 nTPM (protected, limit 2); lung: 16.9 nTPM (vital, limit 1); cerebellum: 16.2 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 10); hypothalamus: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 2); rectum: 12.4 nTPM (protected, limit 2); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 2); adrenal gland: 11.4 nTPM (vital, limit 2); spleen: 11.3 nTPM (manageable, limit 5); skin: 11.3 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); pancreas: 10.5 nTPM (vital, limit 1); salivary gland: 10.4 nTPM (protected, limit 2); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 2); choroid plexus: 4.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139496,NUP58,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 69.5721% (minimum 70%, Approved); cerebellum: 73.0449% (minimum 75%, Missing); lung: 72.2039% (minimum 75%, Missing); lymph node: 68.9168% (minimum 70%, Missing); pituitary gland: 68.3801% (minimum 75%, Missing); retina: 63.3478% (minimum 75%, Missing); thymus: 62.9842% (minimum 65%, Missing); tongue: 66.1145% (minimum 70%, Missing)",-0.0201578,-0.0388554,-0.116522,0,7,partial,25.4,22.5,25.8,"thymus: 25.8 nTPM (manageable, limit 5); retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 2); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 2); bone marrow: 19.2 nTPM (vital, limit 2); skeletal muscle: 18.8 nTPM (vital, limit 2); thyroid gland: 18.3 nTPM (manageable, limit 5); urinary bladder: 17.9 nTPM (protected, limit 2); lung: 16.9 nTPM (vital, limit 1); cerebellum: 16.2 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 10); hypothalamus: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 2); rectum: 12.4 nTPM (protected, limit 2); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 2); adrenal gland: 11.4 nTPM (vital, limit 2); spleen: 11.3 nTPM (manageable, limit 5); skin: 11.3 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); pancreas: 10.5 nTPM (vital, limit 1); salivary gland: 10.4 nTPM (protected, limit 2); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 2); choroid plexus: 4.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139496,NUP58,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 69.5721% (minimum 70%, Approved); cerebellum: 73.0449% (minimum 75%, Missing); lung: 72.2039% (minimum 75%, Missing); lymph node: 68.9168% (minimum 70%, Missing); pituitary gland: 68.3801% (minimum 75%, Missing); retina: 63.3478% (minimum 75%, Missing); thymus: 62.9842% (minimum 65%, Missing); tongue: 66.1145% (minimum 70%, Missing)",-0.0201578,-0.0388554,-0.116522,0,7,partial,25.4,22.5,25.8,"thymus: 25.8 nTPM (manageable, limit 5); retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 3); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 3); bone marrow: 19.2 nTPM (vital, limit 2); skeletal muscle: 18.8 nTPM (vital, limit 2); thyroid gland: 18.3 nTPM (manageable, limit 5); urinary bladder: 17.9 nTPM (protected, limit 3); lung: 16.9 nTPM (vital, limit 1); cerebellum: 16.2 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 10); hypothalamus: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 3); rectum: 12.4 nTPM (protected, limit 3); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 3); adrenal gland: 11.4 nTPM (vital, limit 2); spleen: 11.3 nTPM (manageable, limit 5); skin: 11.3 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); pancreas: 10.5 nTPM (vital, limit 1); salivary gland: 10.4 nTPM (protected, limit 3); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 3); choroid plexus: 4.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139496,NUP58,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 69.5721% (minimum 70%, Approved); cerebellum: 73.0449% (minimum 75%, Missing); lung: 72.2039% (minimum 75%, Missing); lymph node: 68.9168% (minimum 70%, Missing); pituitary gland: 68.3801% (minimum 75%, Missing); retina: 63.3478% (minimum 75%, Missing); thymus: 62.9842% (minimum 65%, Missing); tongue: 66.1145% (minimum 70%, Missing)",-0.0201578,-0.0388554,-0.116522,0,7,partial,25.4,22.5,25.8,"thymus: 25.8 nTPM (manageable, limit 5); retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 3); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 3); bone marrow: 19.2 nTPM (vital, limit 2); skeletal muscle: 18.8 nTPM (vital, limit 2); thyroid gland: 18.3 nTPM (manageable, limit 5); urinary bladder: 17.9 nTPM (protected, limit 3); lung: 16.9 nTPM (vital, limit 1); cerebellum: 16.2 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 10); hypothalamus: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 3); rectum: 12.4 nTPM (protected, limit 3); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 3); adrenal gland: 11.4 nTPM (vital, limit 2); spleen: 11.3 nTPM (manageable, limit 5); skin: 11.3 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); pancreas: 10.5 nTPM (vital, limit 1); salivary gland: 10.4 nTPM (protected, limit 3); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 3); choroid plexus: 4.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139496,NUP58,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 69.5721% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.0449% (minimum 75%, Baseline (adaptation disabled)); lung: 72.2039% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.9168% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 68.3801% (minimum 75%, Baseline (adaptation disabled)); retina: 63.3478% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 70.0159% (minimum 75%, Baseline (adaptation disabled)); thymus: 62.9842% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.1145% (minimum 70%, Baseline (adaptation disabled))",-0.0201578,-0.0388554,-0.116522,0,7,partial,25.4,22.5,25.8,"thymus: 25.8 nTPM (manageable, limit 5); retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 3); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 3); bone marrow: 19.2 nTPM (vital, limit 1); skeletal muscle: 18.8 nTPM (vital, limit 1); thyroid gland: 18.3 nTPM (manageable, limit 5); urinary bladder: 17.9 nTPM (protected, limit 3); lung: 16.9 nTPM (vital, limit 1); cerebellum: 16.2 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); hypothalamus: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 3); rectum: 12.4 nTPM (protected, limit 3); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 3); adrenal gland: 11.4 nTPM (vital, limit 1); spleen: 11.3 nTPM (manageable, limit 5); skin: 11.3 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); pancreas: 10.5 nTPM (vital, limit 1); salivary gland: 10.4 nTPM (protected, limit 3); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 3); choroid plexus: 4.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139496,NUP58,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9071% (minimum 99%, Missing); amygdala: 94.5170% (minimum 99%, Missing); basal ganglia: 91.4141% (minimum 99%, Missing); bone marrow: 96.2766% (minimum 99%, Missing); cerebellum: 98.1030% (minimum 99%, Missing); cerebral cortex: 94.5170% (minimum 99%, Missing); choroid plexus: 65.6987% (minimum 99%, Missing); hippocampal formation: 92.3469% (minimum 99%, Missing); hypothalamus: 91.4141% (minimum 99%, Missing); kidney: 95.5145% (minimum 99%, Missing); lung: 92.8205% (minimum 99%, Missing); midbrain: 97.8378% (minimum 99%, Missing); pancreas: 97.8378% (minimum 99%, Missing); parathyroid gland: 96.2766% (minimum 97%, Missing); pituitary gland: 94.5170% (minimum 99%, Missing); retina: 83.9907% (minimum 99%, Missing); small intestine: 98.6376% (minimum 99%, Missing); spinal cord: 97.8378% (minimum 99%, Missing); thyroid gland: 93.5401% (minimum 95%, Missing)",-0.0145995,-0.00723404,-0.333013,0,80,unavailable,18.9,1.4,2.5,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139537,CCDC65,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.6987% (minimum 75%, Missing)",0.285401,0.262766,-0.0930127,0,80,unavailable,18.9,1.4,2.5,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139537,CCDC65,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.6987% (minimum 75%, Missing)",0.285401,0.262766,-0.0930127,0,80,unavailable,18.9,1.4,2.5,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139537,CCDC65,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.6987% (minimum 75%, Missing)",0.285401,0.262766,-0.0930127,0,80,unavailable,18.9,1.4,2.5,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139537,CCDC65,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.6987% (minimum 75%, Baseline (adaptation disabled))",0.285401,0.262766,-0.0930127,0,80,unavailable,18.9,1.4,2.5,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139537,CCDC65,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.7805% (minimum 99%, Missing); cerebellum: 98.7805% (minimum 99%, Missing); heart muscle: 96.4286% (minimum 99%, Missing); hypothalamus: 98.7805% (minimum 99%, Missing); kidney: 96.4286% (minimum 99%, Missing); lung: 97.0060% (minimum 99%, Missing); midbrain: 98.7805% (minimum 99%, Missing); pituitary gland: 96.4286% (minimum 99%, Missing); small intestine: 97.5904% (minimum 99%, Missing); smooth muscle: 97.5904% (minimum 99%, Missing); spinal cord: 94.1860% (minimum 99%, Missing); urinary bladder: 96.4286% (minimum 97%, Missing)",0.00294118,-0.00571429,-0.0481395,0,80,unavailable,1,0.6,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139549,DHH,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.302941,0.264286,0.19186,0,80,unavailable,1,0.6,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139549,DHH,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.302941,0.264286,0.19186,0,80,unavailable,1,0.6,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139549,DHH,grid_revised,True,False,True,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.302941,0.264286,0.19186,0,80,unavailable,1,0.6,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139549,DHH,current_adaptive,True,False,True,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.302941,0.264286,0.19186,0,80,unavailable,1,0.6,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139549,DHH,current_fixed,True,False,True,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Missing); adrenal gland: 96.7742% (minimum 99%, Missing); bone marrow: 35.7143% (minimum 99%, Missing); cerebral cortex: 96.7742% (minimum 99%, Missing); colon: 78.9474% (minimum 97%, Missing); duodenum: 85.7143% (minimum 99%, Missing); esophagus: 85.7143% (minimum 97%, Missing); kidney: 96.7742% (minimum 99%, Missing); liver: 93.7500% (minimum 99%, Missing); lung: 90.9091% (minimum 99%, Missing); lymph node: 58.8235% (minimum 97%, Missing); pancreas: 96.7742% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); salivary gland: 93.7500% (minimum 97%, Missing); skin: 81.0811% (minimum 95%, Missing); small intestine: 85.7143% (minimum 99%, Missing); smooth muscle: 90.9091% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 81.0811% (minimum 97%, Missing); thymus: 40.5405% (minimum 95%, Missing); thyroid gland: 93.7500% (minimum 95%, Missing); urinary bladder: 85.7143% (minimum 97%, Missing)",-0.544595,-0.381765,-0.632857,0,80,unavailable,5.4,2.1,4.4,"bone marrow: 5.4 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139618,BRCA2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 35.7143% (minimum 75%, Missing); lymph node: 58.8235% (minimum 70%, Missing); thymus: 40.5405% (minimum 65%, Missing)",-0.244595,-0.111765,-0.392857,0,80,unavailable,5.4,2.1,4.4,"bone marrow: 5.4 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139618,BRCA2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 35.7143% (minimum 75%, Missing); lymph node: 58.8235% (minimum 70%, Missing); thymus: 40.5405% (minimum 65%, Missing)",-0.244595,-0.111765,-0.392857,0,80,unavailable,5.4,2.1,4.4,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139618,BRCA2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 35.7143% (minimum 75%, Missing); lymph node: 58.8235% (minimum 70%, Missing); thymus: 40.5405% (minimum 65%, Missing)",-0.244595,-0.111765,-0.392857,0,80,unavailable,5.4,2.1,4.4,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139618,BRCA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 35.7143% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.8235% (minimum 70%, Baseline (adaptation disabled)); thymus: 40.5405% (minimum 65%, Baseline (adaptation disabled))",-0.244595,-0.111765,-0.392857,0,80,unavailable,5.4,2.1,4.4,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139618,BRCA2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.6522% (minimum 99%, Missing); amygdala: 67.6923% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 84.6154% (minimum 99%, Missing); cerebellum: 95.6522% (minimum 99%, Missing); cerebral cortex: 64.7059% (minimum 99%, Missing); choroid plexus: 42.3077% (minimum 99%, Missing); duodenum: 95.6522% (minimum 99%, Missing); heart muscle: 95.6522% (minimum 99%, Missing); hippocampal formation: 63.7681% (minimum 99%, Missing); hypothalamus: 68.7500% (minimum 99%, Missing); kidney: 86.2745% (minimum 99%, Missing); liver: 97.7778% (minimum 99%, Missing); lung: 83.0189% (minimum 99%, Missing); lymph node: 78.5714% (minimum 97%, Missing); midbrain: 89.7959% (minimum 99%, Missing); pancreas: 93.6170% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 78.5714% (minimum 99%, Missing); rectum: 95.6522% (minimum 97%, Missing); retina: 88.0000% (minimum 99%, Missing); salivary gland: 91.6667% (minimum 97%, Missing); skeletal muscle: 97.7778% (minimum 99%, Missing); skin: 70.9677% (minimum 95%, Missing); small intestine: 91.6667% (minimum 99%, Missing); smooth muscle: 95.6522% (minimum 99%, Missing); spinal cord: 91.6667% (minimum 99%, Missing); spleen: 86.2745% (minimum 95%, Missing); stomach: 88.0000% (minimum 97%, Missing); thymus: 83.0189% (minimum 95%, Missing); thyroid gland: 88.0000% (minimum 95%, Missing); urinary bladder: 95.6522% (minimum 97%, Missing)",-0.240323,-0.303333,-0.566923,0,80,unavailable,6,2.2,1.8,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139714,MORN3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 67.6923% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 64.7059% (minimum 75%, Missing); choroid plexus: 42.3077% (minimum 75%, Missing); hippocampal formation: 63.7681% (minimum 75%, Missing); hypothalamus: 68.7500% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing)",0.0596774,-0.0333333,-0.326923,0,80,unavailable,6,2.2,1.8,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139714,MORN3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 67.6923% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 64.7059% (minimum 75%, Missing); choroid plexus: 42.3077% (minimum 75%, Missing); hippocampal formation: 63.7681% (minimum 75%, Missing); hypothalamus: 68.7500% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing)",0.0596774,-0.0333333,-0.326923,0,80,unavailable,6,2.2,1.8,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139714,MORN3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 67.6923% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 64.7059% (minimum 75%, Missing); choroid plexus: 42.3077% (minimum 75%, Missing); hippocampal formation: 63.7681% (minimum 75%, Missing); hypothalamus: 68.7500% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing)",0.0596774,-0.0333333,-0.326923,0,80,unavailable,6,2.2,1.8,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139714,MORN3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 67.6923% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.7059% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 42.3077% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.7681% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.7500% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 70%, Baseline (adaptation disabled))",0.0596774,-0.0333333,-0.326923,0,80,unavailable,6,2.2,1.8,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139714,MORN3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.5659% (minimum 95%, Missing); adrenal gland: 55.4054% (minimum 99%, Missing); amygdala: 59.4203% (minimum 99%, Missing); basal ganglia: 56.1644% (minimum 99%, Missing); bone marrow: 56.5517% (minimum 99%, Missing); cerebellum: 52.2293% (minimum 99%, Missing); cerebral cortex: 51.2500% (minimum 99%, Missing); choroid plexus: 58.9928% (minimum 99%, Missing); colon: 55.4054% (minimum 97%, Missing); duodenum: 62.1212% (minimum 99%, Missing); esophagus: 62.5954% (minimum 97%, Missing); heart muscle: 64.0625% (minimum 99%, Missing); hippocampal formation: 57.3427% (minimum 99%, Missing); hypothalamus: 56.1644% (minimum 99%, Missing); kidney: 65.6000% (minimum 99%, Missing); liver: 58.9928% (minimum 99%, Missing); lung: 61.6541% (minimum 99%, Missing); lymph node: 51.2500% (minimum 97%, Missing); midbrain: 57.7465% (minimum 99%, Missing); pancreas: 60.7407% (minimum 99%, Missing); parathyroid gland: 58.1560% (minimum 97%, Missing); pituitary gland: 47.6744% (minimum 99%, Missing); rectum: 60.7407% (minimum 97%, Missing); retina: 44.8087% (minimum 99%, Missing); salivary gland: 65.0794% (minimum 97%, Missing); skeletal muscle: 48.8095% (minimum 99%, Missing); skin: 55.0336% (minimum 95%, Missing); small intestine: 58.5714% (minimum 99%, Missing); smooth muscle: 56.9444% (minimum 99%, Missing); spinal cord: 56.9444% (minimum 99%, Missing); spleen: 54.6667% (minimum 95%, Missing); stomach: 60.2941% (minimum 97%, Missing); thymus: 46.8571% (minimum 95%, Missing); thyroid gland: 66.1290% (minimum 95%, Missing); tongue: 58.5714% (minimum 97%, Missing); urinary bladder: 61.6541% (minimum 97%, Missing)",-0.481429,-0.4575,-0.541913,0,80,unavailable,10.1,7.8,9.3,"retina: 10.1 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); skin: 6.7 nTPM (manageable, limit 5); colon: 6.6 nTPM (protected, limit 2); adrenal gland: 6.6 nTPM (vital, limit 1); hypothalamus: 6.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 2); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); duodenum: 5 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); heart muscle: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); kidney: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139719,VPS33A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.5659% (minimum 65%, Missing); adrenal gland: 55.4054% (minimum 75%, Missing); amygdala: 59.4203% (minimum 75%, Missing); basal ganglia: 56.1644% (minimum 75%, Missing); bone marrow: 56.5517% (minimum 75%, Missing); cerebellum: 52.2293% (minimum 75%, Missing); cerebral cortex: 51.2500% (minimum 75%, Missing); choroid plexus: 58.9928% (minimum 75%, Missing); colon: 55.4054% (minimum 70%, Missing); duodenum: 62.1212% (minimum 75%, Missing); esophagus: 62.5954% (minimum 70%, Missing); heart muscle: 64.0625% (minimum 75%, Missing); hippocampal formation: 57.3427% (minimum 75%, Missing); hypothalamus: 56.1644% (minimum 75%, Missing); kidney: 65.6000% (minimum 75%, Missing); liver: 58.9928% (minimum 75%, Missing); lung: 61.6541% (minimum 75%, Missing); lymph node: 51.2500% (minimum 70%, Missing); midbrain: 57.7465% (minimum 75%, Missing); pancreas: 60.7407% (minimum 75%, Missing); parathyroid gland: 58.1560% (minimum 70%, Missing); pituitary gland: 47.6744% (minimum 75%, Missing); rectum: 60.7407% (minimum 70%, Missing); retina: 44.8087% (minimum 75%, Missing); salivary gland: 65.0794% (minimum 70%, Missing); skeletal muscle: 48.8095% (minimum 75%, Missing); skin: 55.0336% (minimum 65%, Missing); small intestine: 58.5714% (minimum 75%, Missing); smooth muscle: 56.9444% (minimum 75%, Missing); spinal cord: 56.9444% (minimum 75%, Missing); spleen: 54.6667% (minimum 65%, Missing); stomach: 60.2941% (minimum 70%, Missing); thymus: 46.8571% (minimum 65%, Missing); tongue: 58.5714% (minimum 70%, Missing); urinary bladder: 61.6541% (minimum 70%, Missing)",-0.181429,-0.1875,-0.301913,0,80,unavailable,10.1,7.8,9.3,"retina: 10.1 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); skin: 6.7 nTPM (manageable, limit 5); colon: 6.6 nTPM (protected, limit 2); adrenal gland: 6.6 nTPM (vital, limit 1); hypothalamus: 6.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 2); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); duodenum: 5 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); heart muscle: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); kidney: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139719,VPS33A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.5659% (minimum 65%, Missing); adrenal gland: 55.4054% (minimum 75%, Missing); amygdala: 59.4203% (minimum 75%, Missing); basal ganglia: 56.1644% (minimum 75%, Missing); bone marrow: 56.5517% (minimum 75%, Missing); cerebellum: 52.2293% (minimum 75%, Missing); cerebral cortex: 51.2500% (minimum 75%, Missing); choroid plexus: 58.9928% (minimum 75%, Missing); colon: 55.4054% (minimum 70%, Missing); duodenum: 62.1212% (minimum 75%, Missing); esophagus: 62.5954% (minimum 70%, Missing); heart muscle: 64.0625% (minimum 75%, Missing); hippocampal formation: 57.3427% (minimum 75%, Missing); hypothalamus: 56.1644% (minimum 75%, Missing); kidney: 65.6000% (minimum 75%, Missing); liver: 58.9928% (minimum 75%, Missing); lung: 61.6541% (minimum 75%, Missing); lymph node: 51.2500% (minimum 70%, Missing); midbrain: 57.7465% (minimum 75%, Missing); pancreas: 60.7407% (minimum 75%, Missing); parathyroid gland: 58.1560% (minimum 70%, Missing); pituitary gland: 47.6744% (minimum 75%, Missing); rectum: 60.7407% (minimum 70%, Missing); retina: 44.8087% (minimum 75%, Missing); salivary gland: 65.0794% (minimum 70%, Missing); skeletal muscle: 48.8095% (minimum 75%, Missing); skin: 55.0336% (minimum 65%, Missing); small intestine: 58.5714% (minimum 75%, Missing); smooth muscle: 56.9444% (minimum 75%, Missing); spinal cord: 56.9444% (minimum 75%, Missing); spleen: 54.6667% (minimum 65%, Missing); stomach: 60.2941% (minimum 70%, Missing); thymus: 46.8571% (minimum 65%, Missing); tongue: 58.5714% (minimum 70%, Missing); urinary bladder: 61.6541% (minimum 70%, Missing)",-0.181429,-0.1875,-0.301913,0,80,unavailable,10.1,7.8,9.3,"retina: 10.1 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); skin: 6.7 nTPM (manageable, limit 5); colon: 6.6 nTPM (protected, limit 3); adrenal gland: 6.6 nTPM (vital, limit 1); hypothalamus: 6.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 3); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 3); duodenum: 5 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 3); heart muscle: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); kidney: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139719,VPS33A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.5659% (minimum 65%, Missing); adrenal gland: 55.4054% (minimum 75%, Missing); amygdala: 59.4203% (minimum 75%, Missing); basal ganglia: 56.1644% (minimum 75%, Missing); bone marrow: 56.5517% (minimum 75%, Missing); cerebellum: 52.2293% (minimum 75%, Missing); cerebral cortex: 51.2500% (minimum 75%, Missing); choroid plexus: 58.9928% (minimum 75%, Missing); colon: 55.4054% (minimum 70%, Missing); duodenum: 62.1212% (minimum 75%, Missing); esophagus: 62.5954% (minimum 70%, Missing); heart muscle: 64.0625% (minimum 75%, Missing); hippocampal formation: 57.3427% (minimum 75%, Missing); hypothalamus: 56.1644% (minimum 75%, Missing); kidney: 65.6000% (minimum 75%, Missing); liver: 58.9928% (minimum 75%, Missing); lung: 61.6541% (minimum 75%, Missing); lymph node: 51.2500% (minimum 70%, Missing); midbrain: 57.7465% (minimum 75%, Missing); pancreas: 60.7407% (minimum 75%, Missing); parathyroid gland: 58.1560% (minimum 70%, Missing); pituitary gland: 47.6744% (minimum 75%, Missing); rectum: 60.7407% (minimum 70%, Missing); retina: 44.8087% (minimum 75%, Missing); salivary gland: 65.0794% (minimum 70%, Missing); skeletal muscle: 48.8095% (minimum 75%, Missing); skin: 55.0336% (minimum 65%, Missing); small intestine: 58.5714% (minimum 75%, Missing); smooth muscle: 56.9444% (minimum 75%, Missing); spinal cord: 56.9444% (minimum 75%, Missing); spleen: 54.6667% (minimum 65%, Missing); stomach: 60.2941% (minimum 70%, Missing); thymus: 46.8571% (minimum 65%, Missing); tongue: 58.5714% (minimum 70%, Missing); urinary bladder: 61.6541% (minimum 70%, Missing)",-0.181429,-0.1875,-0.301913,0,80,unavailable,10.1,7.8,9.3,"retina: 10.1 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); skin: 6.7 nTPM (manageable, limit 5); colon: 6.6 nTPM (protected, limit 3); adrenal gland: 6.6 nTPM (vital, limit 1); hypothalamus: 6.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 3); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 3); duodenum: 5 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 3); heart muscle: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); kidney: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139719,VPS33A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.5659% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 55.4054% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.4203% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.1644% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 56.5517% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 52.2293% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.2500% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.9928% (minimum 75%, Baseline (adaptation disabled)); colon: 55.4054% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.1212% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.5954% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.0625% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.3427% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 56.1644% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.6000% (minimum 75%, Baseline (adaptation disabled)); liver: 58.9928% (minimum 75%, Baseline (adaptation disabled)); lung: 61.6541% (minimum 75%, Baseline (adaptation disabled)); lymph node: 51.2500% (minimum 70%, Baseline (adaptation disabled)); midbrain: 57.7465% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.7407% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.1560% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 47.6744% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.7407% (minimum 70%, Baseline (adaptation disabled)); retina: 44.8087% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.0794% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 48.8095% (minimum 75%, Baseline (adaptation disabled)); skin: 55.0336% (minimum 65%, Baseline (adaptation disabled)); small intestine: 58.5714% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.9444% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.9444% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.6667% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.2941% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.8571% (minimum 65%, Baseline (adaptation disabled)); tongue: 58.5714% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.6541% (minimum 70%, Baseline (adaptation disabled))",-0.181429,-0.1875,-0.301913,0,80,unavailable,10.1,7.8,9.3,"retina: 10.1 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); skin: 6.7 nTPM (manageable, limit 5); colon: 6.6 nTPM (protected, limit 3); adrenal gland: 6.6 nTPM (vital, limit 1); hypothalamus: 6.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 3); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 3); duodenum: 5 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 3); heart muscle: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); kidney: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139719,VPS33A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.8115% (minimum 99%, Missing); basal ganglia: 95.8115% (minimum 99%, Missing); bone marrow: 72.3320% (minimum 99%, Missing); cerebral cortex: 95.8115% (minimum 99%, Missing); colon: 91.0448% (minimum 97%, Missing); duodenum: 91.0448% (minimum 99%, Missing); esophagus: 89.7059% (minimum 97%, Missing); hippocampal formation: 97.3404% (minimum 99%, Missing); hypothalamus: 96.3158% (minimum 99%, Missing); kidney: 95.8115% (minimum 99%, Missing); liver: 98.9189% (minimum 99%, Missing); lung: 93.8462% (minimum 99%, Missing); lymph node: 88.8350% (minimum 97%, Missing); midbrain: 97.3404% (minimum 99%, Missing); pancreas: 98.9189% (minimum 99%, Missing); rectum: 90.1478% (minimum 97%, Missing); skin: 93.8462% (minimum 95%, Missing); small intestine: 91.9598% (minimum 99%, Missing); smooth muscle: 87.9808% (minimum 99%, Missing); spinal cord: 98.9189% (minimum 99%, Missing); stomach: 92.4242% (minimum 97%, Missing); thymus: 77.5424% (minimum 95%, Missing); urinary bladder: 96.8254% (minimum 97%, Missing)",-0.174576,-0.0816505,-0.26668,0,80,unavailable,7,2.3,5.3,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); smooth muscle: 2.5 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); esophagus: 2.1 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139734,DIAPH3,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.3320% (minimum 75%, Missing)",0.125424,0.18835,-0.0266798,0,80,unavailable,7,2.3,5.3,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); smooth muscle: 2.5 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); esophagus: 2.1 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139734,DIAPH3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.3320% (minimum 75%, Missing)",0.125424,0.18835,-0.0266798,0,80,unavailable,7,2.3,5.3,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); smooth muscle: 2.5 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139734,DIAPH3,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.3320% (minimum 75%, Missing)",0.125424,0.18835,-0.0266798,0,80,unavailable,7,2.3,5.3,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); smooth muscle: 2.5 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139734,DIAPH3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.3320% (minimum 75%, Baseline (adaptation disabled))",0.125424,0.18835,-0.0266798,0,80,unavailable,7,2.3,5.3,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); smooth muscle: 2.5 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139734,DIAPH3,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.0056427,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139797,RNF113B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245643,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139797,RNF113B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245643,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139797,RNF113B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245643,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139797,RNF113B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245643,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139797,RNF113B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 99%, Missing); basal ganglia: 81.8182% (minimum 99%, Missing); cerebellum: 11.7647% (minimum 99%, Missing); cerebral cortex: 61.0169% (minimum 99%, Missing); choroid plexus: 40.4494% (minimum 99%, Missing); hippocampal formation: 67.9245% (minimum 99%, Missing); hypothalamus: 81.8182% (minimum 99%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pituitary gland: 94.7368% (minimum 99%, Missing); retina: 52.1739% (minimum 99%, Missing); spinal cord: 76.5957% (minimum 99%, Missing)",0.05,0.03,-0.872353,0,80,unavailable,27,0,0,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139800,ZIC5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 75%, Missing); cerebellum: 11.7647% (minimum 75%, Missing); cerebral cortex: 61.0169% (minimum 75%, Missing); choroid plexus: 40.4494% (minimum 75%, Missing); hippocampal formation: 67.9245% (minimum 75%, Missing); retina: 52.1739% (minimum 75%, Missing)",0.35,0.3,-0.632353,0,80,unavailable,27,0,0,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139800,ZIC5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 75%, Missing); cerebellum: 11.7647% (minimum 75%, Missing); cerebral cortex: 61.0169% (minimum 75%, Missing); choroid plexus: 40.4494% (minimum 75%, Missing); hippocampal formation: 67.9245% (minimum 75%, Missing); retina: 52.1739% (minimum 75%, Missing)",0.35,0.3,-0.632353,0,80,unavailable,27,0,0,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139800,ZIC5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 75%, Missing); cerebellum: 11.7647% (minimum 75%, Missing); cerebral cortex: 61.0169% (minimum 75%, Missing); choroid plexus: 40.4494% (minimum 75%, Missing); hippocampal formation: 67.9245% (minimum 75%, Missing); retina: 52.1739% (minimum 75%, Missing)",0.35,0.3,-0.632353,0,80,unavailable,27,0,0,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139800,ZIC5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 11.7647% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.0169% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 40.4494% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.9245% (minimum 75%, Baseline (adaptation disabled)); retina: 52.1739% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.632353,0,80,unavailable,27,0,0,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139800,ZIC5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.0370% (minimum 95%, Missing); adrenal gland: 92.1569% (minimum 99%, Missing); amygdala: 90.3846% (minimum 99%, Missing); basal ganglia: 38.5246% (minimum 99%, Missing); bone marrow: 32.6389% (minimum 99%, Missing); cerebellum: 61.8421% (minimum 99%, Missing); cerebral cortex: 75.8065% (minimum 99%, Missing); choroid plexus: 78.3333% (minimum 99%, Missing); colon: 79.6610% (minimum 97%, Missing); duodenum: 94.0000% (minimum 99%, Missing); esophagus: 87.0370% (minimum 97%, Missing); heart muscle: 92.1569% (minimum 99%, Missing); hippocampal formation: 77.0492% (minimum 99%, Missing); hypothalamus: 72.3077% (minimum 99%, Missing); kidney: 74.6032% (minimum 99%, Missing); liver: 88.6792% (minimum 99%, Missing); lung: 68.1159% (minimum 99%, Missing); lymph node: 83.9286% (minimum 97%, Missing); midbrain: 92.1569% (minimum 99%, Missing); pancreas: 90.3846% (minimum 99%, Missing); parathyroid gland: 78.3333% (minimum 97%, Missing); pituitary gland: 45.6311% (minimum 99%, Missing); retina: 90.3846% (minimum 99%, Missing); salivary gland: 85.4545% (minimum 97%, Missing); skeletal muscle: 85.4545% (minimum 99%, Missing); skin: 69.1176% (minimum 95%, Missing); small intestine: 70.1493% (minimum 99%, Missing); smooth muscle: 95.9184% (minimum 99%, Missing); spinal cord: 88.6792% (minimum 99%, Missing); spleen: 45.1923% (minimum 95%, Missing); stomach: 85.4545% (minimum 97%, Missing); thymus: 88.6792% (minimum 95%, Missing); thyroid gland: 82.4561% (minimum 95%, Missing); tongue: 94.0000% (minimum 97%, Missing); urinary bladder: 82.4561% (minimum 97%, Missing)",-0.498077,-0.186667,-0.663611,0,80,unavailable,9.7,1.3,5.7,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139890,REM2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 38.5246% (minimum 75%, Missing); bone marrow: 32.6389% (minimum 75%, Missing); cerebellum: 61.8421% (minimum 75%, Missing); hypothalamus: 72.3077% (minimum 75%, Missing); kidney: 74.6032% (minimum 75%, Missing); lung: 68.1159% (minimum 75%, Missing); pituitary gland: 45.6311% (minimum 75%, Missing); small intestine: 70.1493% (minimum 75%, Missing); spleen: 45.1923% (minimum 65%, Missing)",-0.198077,0.0833333,-0.423611,0,80,unavailable,9.7,1.3,5.7,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139890,REM2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 38.5246% (minimum 75%, Missing); bone marrow: 32.6389% (minimum 75%, Missing); cerebellum: 61.8421% (minimum 75%, Missing); hypothalamus: 72.3077% (minimum 75%, Missing); kidney: 74.6032% (minimum 75%, Missing); lung: 68.1159% (minimum 75%, Missing); pituitary gland: 45.6311% (minimum 75%, Missing); small intestine: 70.1493% (minimum 75%, Missing); spleen: 45.1923% (minimum 65%, Missing)",-0.198077,0.0833333,-0.423611,0,80,unavailable,9.7,1.3,5.7,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139890,REM2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 38.5246% (minimum 75%, Missing); bone marrow: 32.6389% (minimum 75%, Missing); cerebellum: 61.8421% (minimum 75%, Missing); hypothalamus: 72.3077% (minimum 75%, Missing); kidney: 74.6032% (minimum 75%, Missing); lung: 68.1159% (minimum 75%, Missing); pituitary gland: 45.6311% (minimum 75%, Missing); small intestine: 70.1493% (minimum 75%, Missing); spleen: 45.1923% (minimum 65%, Missing)",-0.198077,0.0833333,-0.423611,0,80,unavailable,9.7,1.3,5.7,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139890,REM2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 38.5246% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 32.6389% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.8421% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.3077% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.6032% (minimum 75%, Baseline (adaptation disabled)); lung: 68.1159% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 45.6311% (minimum 75%, Baseline (adaptation disabled)); small intestine: 70.1493% (minimum 75%, Baseline (adaptation disabled)); spleen: 45.1923% (minimum 65%, Baseline (adaptation disabled))",-0.198077,0.0833333,-0.423611,0,80,unavailable,9.7,1.3,5.7,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139890,REM2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.8718% (minimum 99%, Uncertain); amygdala: 78.7234% (minimum 99%, Missing); basal ganglia: 82.2222% (minimum 99%, Missing); cerebellum: 94.8718% (minimum 99%, Uncertain); cerebral cortex: 51.3889% (minimum 99%, Uncertain); choroid plexus: 94.8718% (minimum 99%, Missing); hippocampal formation: 80.4348% (minimum 99%, Missing); hypothalamus: 74.0000% (minimum 99%, Missing); kidney: 97.3684% (minimum 99%, Uncertain); liver: 97.3684% (minimum 99%, Uncertain); midbrain: 84.0909% (minimum 99%, Missing); retina: 46.2500% (minimum 99%, Missing); skin: 92.5000% (minimum 95%, Uncertain); spinal cord: 68.5185% (minimum 99%, Missing); stomach: 94.8718% (minimum 97%, Uncertain)",-0.025,-0.0212821,-0.5275,0,4,partial,4.3,0.2,0.3,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,51,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139915,MDGA2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 51.3889% (minimum 75%, Uncertain); hypothalamus: 74.0000% (minimum 75%, Missing); retina: 46.2500% (minimum 75%, Missing); spinal cord: 68.5185% (minimum 75%, Missing)",0.275,0.248718,-0.2875,0,4,partial,4.3,0.2,0.3,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,51,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139915,MDGA2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 51.3889% (minimum 75%, Uncertain); hypothalamus: 74.0000% (minimum 75%, Missing); retina: 46.2500% (minimum 75%, Missing); spinal cord: 68.5185% (minimum 75%, Missing)",0.275,0.248718,-0.2875,0,4,partial,4.3,0.2,0.3,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,51,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139915,MDGA2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 51.3889% (minimum 75%, Uncertain); hypothalamus: 74.0000% (minimum 75%, Missing); retina: 46.2500% (minimum 75%, Missing); spinal cord: 68.5185% (minimum 75%, Missing)",0.275,0.248718,-0.2875,0,4,partial,4.3,0.2,0.3,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,51,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139915,MDGA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 51.3889% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 46.2500% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.5185% (minimum 75%, Baseline (adaptation disabled))",0.275,0.248718,-0.2875,0,4,partial,4.3,0.2,0.3,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,51,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000139915,MDGA2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2047% (minimum 95%, Uncertain); adrenal gland: 58.0882% (minimum 99%, Missing); amygdala: 65.2893% (minimum 99%, Missing); basal ganglia: 64.7541% (minimum 99%, Missing); bone marrow: 72.4771% (minimum 99%, Uncertain); cerebellum: 58.0882% (minimum 99%, Uncertain); cerebral cortex: 60.7692% (minimum 99%, Missing); choroid plexus: 74.5283% (minimum 99%, Missing); colon: 57.2464% (minimum 97%, Missing); duodenum: 61.7188% (minimum 99%, Missing); esophagus: 60.7692% (minimum 97%, Uncertain); heart muscle: 65.2893% (minimum 99%, Uncertain); hippocampal formation: 65.8333% (minimum 99%, Missing); hypothalamus: 65.8333% (minimum 99%, Missing); kidney: 48.1707% (minimum 99%, Missing); liver: 48.1707% (minimum 99%, Missing); lung: 59.8485% (minimum 99%, Missing); lymph node: 41.7989% (minimum 97%, Missing); midbrain: 68.6957% (minimum 99%, Missing); pancreas: 58.0882% (minimum 99%, Missing); parathyroid gland: 52.3179% (minimum 97%, Missing); pituitary gland: 72.4771% (minimum 99%, Missing); rectum: 54.8611% (minimum 97%, Missing); retina: 41.7989% (minimum 99%, Missing); salivary gland: 66.9492% (minimum 97%, Missing); skeletal muscle: 58.5185% (minimum 99%, Uncertain); skin: 56.8345% (minimum 95%, Uncertain); small intestine: 66.9492% (minimum 99%, Missing); smooth muscle: 60.7692% (minimum 99%, Uncertain); spinal cord: 64.2276% (minimum 99%, Missing); spleen: 48.4663% (minimum 95%, Uncertain); stomach: 59.8485% (minimum 97%, Missing); thymus: 44.6328% (minimum 95%, Missing); thyroid gland: 47.0238% (minimum 95%, Missing); tongue: 53.0201% (minimum 97%, Missing); urinary bladder: 55.2448% (minimum 97%, Missing)",-0.503672,-0.552011,-0.572011,0,4,partial,11,11,9.8,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 2); tongue: 7 nTPM (protected, limit 2); rectum: 6.5 nTPM (protected, limit 2); urinary bladder: 6.4 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); colon: 5.9 nTPM (protected, limit 2); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); esophagus: 5.1 nTPM (protected, limit 2); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140006,WDR89,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2047% (minimum 65%, Uncertain); adrenal gland: 58.0882% (minimum 75%, Missing); amygdala: 65.2893% (minimum 75%, Missing); basal ganglia: 64.7541% (minimum 75%, Missing); bone marrow: 72.4771% (minimum 75%, Uncertain); cerebellum: 58.0882% (minimum 75%, Uncertain); cerebral cortex: 60.7692% (minimum 75%, Missing); choroid plexus: 74.5283% (minimum 75%, Missing); colon: 57.2464% (minimum 70%, Missing); duodenum: 61.7188% (minimum 75%, Missing); esophagus: 60.7692% (minimum 70%, Uncertain); heart muscle: 65.2893% (minimum 75%, Uncertain); hippocampal formation: 65.8333% (minimum 75%, Missing); hypothalamus: 65.8333% (minimum 75%, Missing); kidney: 48.1707% (minimum 75%, Missing); liver: 48.1707% (minimum 75%, Missing); lung: 59.8485% (minimum 75%, Missing); lymph node: 41.7989% (minimum 70%, Missing); midbrain: 68.6957% (minimum 75%, Missing); pancreas: 58.0882% (minimum 75%, Missing); parathyroid gland: 52.3179% (minimum 70%, Missing); pituitary gland: 72.4771% (minimum 75%, Missing); rectum: 54.8611% (minimum 70%, Missing); retina: 41.7989% (minimum 75%, Missing); salivary gland: 66.9492% (minimum 70%, Missing); skeletal muscle: 58.5185% (minimum 75%, Uncertain); skin: 56.8345% (minimum 65%, Uncertain); small intestine: 66.9492% (minimum 75%, Missing); smooth muscle: 60.7692% (minimum 75%, Uncertain); spinal cord: 64.2276% (minimum 75%, Missing); spleen: 48.4663% (minimum 65%, Uncertain); stomach: 59.8485% (minimum 70%, Missing); thymus: 44.6328% (minimum 65%, Missing); thyroid gland: 47.0238% (minimum 65%, Missing); tongue: 53.0201% (minimum 70%, Missing); urinary bladder: 55.2448% (minimum 70%, Missing)",-0.203672,-0.282011,-0.332011,0,4,partial,11,11,9.8,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 2); tongue: 7 nTPM (protected, limit 2); rectum: 6.5 nTPM (protected, limit 2); urinary bladder: 6.4 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); colon: 5.9 nTPM (protected, limit 2); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); esophagus: 5.1 nTPM (protected, limit 2); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140006,WDR89,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2047% (minimum 65%, Uncertain); adrenal gland: 58.0882% (minimum 75%, Missing); amygdala: 65.2893% (minimum 75%, Missing); basal ganglia: 64.7541% (minimum 75%, Missing); bone marrow: 72.4771% (minimum 75%, Uncertain); cerebellum: 58.0882% (minimum 75%, Uncertain); cerebral cortex: 60.7692% (minimum 75%, Missing); choroid plexus: 74.5283% (minimum 75%, Missing); colon: 57.2464% (minimum 70%, Missing); duodenum: 61.7188% (minimum 75%, Missing); esophagus: 60.7692% (minimum 70%, Uncertain); heart muscle: 65.2893% (minimum 75%, Uncertain); hippocampal formation: 65.8333% (minimum 75%, Missing); hypothalamus: 65.8333% (minimum 75%, Missing); kidney: 48.1707% (minimum 75%, Missing); liver: 48.1707% (minimum 75%, Missing); lung: 59.8485% (minimum 75%, Missing); lymph node: 41.7989% (minimum 70%, Missing); midbrain: 68.6957% (minimum 75%, Missing); pancreas: 58.0882% (minimum 75%, Missing); parathyroid gland: 52.3179% (minimum 70%, Missing); pituitary gland: 72.4771% (minimum 75%, Missing); rectum: 54.8611% (minimum 70%, Missing); retina: 41.7989% (minimum 75%, Missing); salivary gland: 66.9492% (minimum 70%, Missing); skeletal muscle: 58.5185% (minimum 75%, Uncertain); skin: 56.8345% (minimum 65%, Uncertain); small intestine: 66.9492% (minimum 75%, Missing); smooth muscle: 60.7692% (minimum 75%, Uncertain); spinal cord: 64.2276% (minimum 75%, Missing); spleen: 48.4663% (minimum 65%, Uncertain); stomach: 59.8485% (minimum 70%, Missing); thymus: 44.6328% (minimum 65%, Missing); thyroid gland: 47.0238% (minimum 65%, Missing); tongue: 53.0201% (minimum 70%, Missing); urinary bladder: 55.2448% (minimum 70%, Missing)",-0.203672,-0.282011,-0.332011,0,4,partial,11,11,9.8,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 3); tongue: 7 nTPM (protected, limit 3); rectum: 6.5 nTPM (protected, limit 3); urinary bladder: 6.4 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); colon: 5.9 nTPM (protected, limit 3); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); esophagus: 5.1 nTPM (protected, limit 3); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140006,WDR89,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2047% (minimum 65%, Uncertain); adrenal gland: 58.0882% (minimum 75%, Missing); amygdala: 65.2893% (minimum 75%, Missing); basal ganglia: 64.7541% (minimum 75%, Missing); bone marrow: 72.4771% (minimum 75%, Uncertain); cerebellum: 58.0882% (minimum 75%, Uncertain); cerebral cortex: 60.7692% (minimum 75%, Missing); choroid plexus: 74.5283% (minimum 75%, Missing); colon: 57.2464% (minimum 70%, Missing); duodenum: 61.7188% (minimum 75%, Missing); esophagus: 60.7692% (minimum 70%, Uncertain); heart muscle: 65.2893% (minimum 75%, Uncertain); hippocampal formation: 65.8333% (minimum 75%, Missing); hypothalamus: 65.8333% (minimum 75%, Missing); kidney: 48.1707% (minimum 75%, Missing); liver: 48.1707% (minimum 75%, Missing); lung: 59.8485% (minimum 75%, Missing); lymph node: 41.7989% (minimum 70%, Missing); midbrain: 68.6957% (minimum 75%, Missing); pancreas: 58.0882% (minimum 75%, Missing); parathyroid gland: 52.3179% (minimum 70%, Missing); pituitary gland: 72.4771% (minimum 75%, Missing); rectum: 54.8611% (minimum 70%, Missing); retina: 41.7989% (minimum 75%, Missing); salivary gland: 66.9492% (minimum 70%, Missing); skeletal muscle: 58.5185% (minimum 75%, Uncertain); skin: 56.8345% (minimum 65%, Uncertain); small intestine: 66.9492% (minimum 75%, Missing); smooth muscle: 60.7692% (minimum 75%, Uncertain); spinal cord: 64.2276% (minimum 75%, Missing); spleen: 48.4663% (minimum 65%, Uncertain); stomach: 59.8485% (minimum 70%, Missing); thymus: 44.6328% (minimum 65%, Missing); thyroid gland: 47.0238% (minimum 65%, Missing); tongue: 53.0201% (minimum 70%, Missing); urinary bladder: 55.2448% (minimum 70%, Missing)",-0.203672,-0.282011,-0.332011,0,4,partial,11,11,9.8,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 3); tongue: 7 nTPM (protected, limit 3); rectum: 6.5 nTPM (protected, limit 3); urinary bladder: 6.4 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); colon: 5.9 nTPM (protected, limit 3); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); esophagus: 5.1 nTPM (protected, limit 3); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140006,WDR89,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2047% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 58.0882% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.2893% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.7541% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 72.4771% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 58.0882% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.7692% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.5283% (minimum 75%, Baseline (adaptation disabled)); colon: 57.2464% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.7188% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.7692% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.2893% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.8333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.8333% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.1707% (minimum 75%, Baseline (adaptation disabled)); liver: 48.1707% (minimum 75%, Baseline (adaptation disabled)); lung: 59.8485% (minimum 75%, Baseline (adaptation disabled)); lymph node: 41.7989% (minimum 70%, Baseline (adaptation disabled)); midbrain: 68.6957% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.0882% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.3179% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.4771% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.8611% (minimum 70%, Baseline (adaptation disabled)); retina: 41.7989% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.9492% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 58.5185% (minimum 75%, Baseline (adaptation disabled)); skin: 56.8345% (minimum 65%, Baseline (adaptation disabled)); small intestine: 66.9492% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.7692% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.2276% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.4663% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.8485% (minimum 70%, Baseline (adaptation disabled)); thymus: 44.6328% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 47.0238% (minimum 65%, Baseline (adaptation disabled)); tongue: 53.0201% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 55.2448% (minimum 70%, Baseline (adaptation disabled))",-0.203672,-0.282011,-0.332011,0,4,partial,11,11,9.8,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 3); tongue: 7 nTPM (protected, limit 3); rectum: 6.5 nTPM (protected, limit 3); urinary bladder: 6.4 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); colon: 5.9 nTPM (protected, limit 3); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); esophagus: 5.1 nTPM (protected, limit 3); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140006,WDR89,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.2456% (minimum 99%, Missing); amygdala: 98.2143% (minimum 99%, Missing); basal ganglia: 96.4912% (minimum 99%, Missing); bone marrow: 85.9375% (minimum 95%, Enhanced); cerebellum: 88.7097% (minimum 95%, Enhanced); cerebral cortex: 94.8276% (minimum 95%, Enhanced); choroid plexus: 98.2143% (minimum 99%, Missing); duodenum: 85.9375% (minimum 95%, Enhanced); heart muscle: 90.1639% (minimum 95%, Enhanced); hippocampal formation: 98.2143% (minimum 99%, Missing); hypothalamus: 94.8276% (minimum 99%, Missing); kidney: 79.7101% (minimum 95%, Enhanced); liver: 88.7097% (minimum 95%, Enhanced); lung: 90.1639% (minimum 95%, Enhanced); lymph node: 73.3333% (minimum 97%, Missing); midbrain: 98.2143% (minimum 99%, Missing); pancreas: 73.3333% (minimum 95%, Enhanced); pituitary gland: 88.7097% (minimum 99%, Missing); rectum: 85.9375% (minimum 97%, Missing); retina: 75.3425% (minimum 99%, Missing); skeletal muscle: 80.8824% (minimum 95%, Enhanced); small intestine: 82.0896% (minimum 95%, Enhanced); smooth muscle: 94.8276% (minimum 95%, Enhanced); spinal cord: 98.2143% (minimum 99%, Missing); thymus: 69.6203% (minimum 95%, Missing); tongue: 96.4912% (minimum 97%, Missing)",-0.253797,-0.236667,-0.507544,0,2,partial,5.9,2,2.4,"adrenal gland: 5.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140009,ESR2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.2456% (minimum 75%, Missing)",0.0462025,0.0333333,-0.267544,0,2,partial,5.9,2,2.4,"adrenal gland: 5.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140009,ESR2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.2456% (minimum 75%, Missing)",0.0462025,0.0333333,-0.267544,0,2,partial,5.9,2,2.4,"adrenal gland: 5.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140009,ESR2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.2456% (minimum 75%, Missing)",0.0462025,0.0333333,-0.267544,0,2,partial,5.9,2,2.4,"adrenal gland: 5.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140009,ESR2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.2456% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.3333% (minimum 75%, Baseline (adaptation disabled))",0.0462025,0.0333333,-0.267544,0,2,partial,5.9,2,2.4,"adrenal gland: 5.9 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140009,ESR2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 95%, Missing); adrenal gland: 23.0769% (minimum 99%, Missing); amygdala: 33.3333% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); cerebral cortex: 11.5385% (minimum 99%, Missing); choroid plexus: 37.5000% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 23.0769% (minimum 99%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pituitary gland: 50.0000% (minimum 99%, Missing); retina: 6.5217% (minimum 99%, Missing); spinal cord: 60.0000% (minimum 99%, Missing)",-0.35,0.03,-0.924783,0,80,unavailable,4.3,0,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140015,KCNH5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); adrenal gland: 23.0769% (minimum 75%, Missing); amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); cerebral cortex: 11.5385% (minimum 75%, Missing); choroid plexus: 37.5000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 23.0769% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 6.5217% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing)",-0.05,0.3,-0.684783,0,80,unavailable,4.3,0,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140015,KCNH5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); adrenal gland: 23.0769% (minimum 75%, Missing); amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); cerebral cortex: 11.5385% (minimum 75%, Missing); choroid plexus: 37.5000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 23.0769% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 6.5217% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing)",-0.05,0.3,-0.684783,0,80,unavailable,4.3,0,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140015,KCNH5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); adrenal gland: 23.0769% (minimum 75%, Missing); amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); cerebral cortex: 11.5385% (minimum 75%, Missing); choroid plexus: 37.5000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 23.0769% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 6.5217% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing)",-0.05,0.3,-0.684783,0,80,unavailable,4.3,0,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140015,KCNH5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 23.0769% (minimum 75%, Baseline (adaptation disabled)); amygdala: 33.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 11.5385% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 37.5000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 23.0769% (minimum 75%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 6.5217% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 60.0000% (minimum 75%, Baseline (adaptation disabled))",-0.05,0.3,-0.684783,0,80,unavailable,4.3,0,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140015,KCNH5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.1481% (minimum 95%, Missing); adrenal gland: 89.9244% (minimum 99%, Missing); amygdala: 82.4480% (minimum 99%, Missing); basal ganglia: 85.0000% (minimum 99%, Missing); bone marrow: 85.8173% (minimum 99%, Missing); cerebellum: 94.4444% (minimum 99%, Missing); cerebral cortex: 87.9310% (minimum 99%, Missing); choroid plexus: 86.6505% (minimum 99%, Missing); colon: 87.2861% (minimum 97%, Missing); duodenum: 87.9310% (minimum 99%, Missing); esophagus: 88.3663% (minimum 97%, Missing); heart muscle: 93.4555% (minimum 99%, Missing); hippocampal formation: 85.8173% (minimum 99%, Missing); hypothalamus: 87.7150% (minimum 99%, Missing); kidney: 83.0233% (minimum 99%, Missing); liver: 86.0241% (minimum 99%, Missing); lung: 92.2481% (minimum 99%, Missing); lymph node: 90.8397% (minimum 97%, Missing); midbrain: 82.8306% (minimum 99%, Missing); pancreas: 88.3663% (minimum 99%, Missing); parathyroid gland: 81.8807% (minimum 97%, Missing); pituitary gland: 91.7738% (minimum 99%, Missing); rectum: 87.0732% (minimum 97%, Missing); retina: 85.6115% (minimum 99%, Missing); salivary gland: 88.5856% (minimum 97%, Missing); skeletal muscle: 94.9468% (minimum 99%, Missing); skin: 92.0103% (minimum 95%, Missing); small intestine: 90.6091% (minimum 99%, Missing); smooth muscle: 90.6091% (minimum 99%, Missing); spinal cord: 84.3972% (minimum 99%, Missing); spleen: 91.3043% (minimum 95%, Missing); stomach: 89.0274% (minimum 97%, Missing); thymus: 89.4737% (minimum 95%, Missing); thyroid gland: 82.4480% (minimum 95%, Missing); tongue: 93.9474% (minimum 97%, Missing); urinary bladder: 88.8060% (minimum 97%, Missing)",-0.12552,-0.151193,-0.16552,0,80,unavailable,7.6,7.9,7.6,"parathyroid gland: 7.9 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); urinary bladder: 4.5 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140025,EFCAB11,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17448,0.118807,0.0744804,0,80,unavailable,7.6,7.9,7.6,"parathyroid gland: 7.9 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); urinary bladder: 4.5 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140025,EFCAB11,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17448,0.118807,0.0744804,0,80,unavailable,7.6,7.9,7.6,"parathyroid gland: 7.9 nTPM (protected, limit 3); thyroid gland: 7.6 nTPM (manageable, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 3); urinary bladder: 4.5 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140025,EFCAB11,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17448,0.118807,0.0744804,0,80,unavailable,7.6,7.9,7.6,"parathyroid gland: 7.9 nTPM (protected, limit 3); thyroid gland: 7.6 nTPM (manageable, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 3); urinary bladder: 4.5 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140025,EFCAB11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17448,0.118807,0.0744804,0,80,unavailable,7.6,7.9,7.6,"parathyroid gland: 7.9 nTPM (protected, limit 3); thyroid gland: 7.6 nTPM (manageable, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 3); urinary bladder: 4.5 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140025,EFCAB11,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4894% (minimum 90%, Approved); adrenal gland: 58.7413% (minimum 99%, Missing); amygdala: 55.6291% (minimum 99%, Missing); basal ganglia: 55.2632% (minimum 99%, Missing); bone marrow: 97.1098% (minimum 98%, Approved); cerebellum: 74.3363% (minimum 99%, Missing); cerebral cortex: 57.3379% (minimum 99%, Missing); choroid plexus: 50.9091% (minimum 99%, Missing); colon: 70.5882% (minimum 97%, Missing); duodenum: 58.7413% (minimum 99%, Missing); esophagus: 77.7778% (minimum 95%, Approved); heart muscle: 38.8889% (minimum 99%, Missing); hippocampal formation: 59.7865% (minimum 99%, Missing); hypothalamus: 60.2151% (minimum 99%, Missing); kidney: 48.0000% (minimum 99%, Missing); liver: 47.5921% (minimum 99%, Missing); lung: 75.6757% (minimum 99%, Missing); lymph node: 84.8485% (minimum 97%, Missing); midbrain: 53.5032% (minimum 99%, Missing); pancreas: 76.7123% (minimum 99%, Missing); parathyroid gland: 62.2222% (minimum 97%, Missing); pituitary gland: 69.4215% (minimum 99%, Missing); rectum: 75.3363% (minimum 97%, Missing); retina: 61.5385% (minimum 99%, Missing); salivary gland: 71.7949% (minimum 97%, Missing); skeletal muscle: 34.6392% (minimum 99%, Missing); skin: 71.1864% (minimum 95%, Missing); small intestine: 65.8824% (minimum 99%, Missing); smooth muscle: 87.0466% (minimum 98%, Approved); spinal cord: 57.5342% (minimum 99%, Missing); spleen: 83.5821% (minimum 95%, Missing); stomach: 73.3624% (minimum 97%, Missing); thymus: 85.2792% (minimum 95%, Missing); thyroid gland: 57.7320% (minimum 95%, Missing); tongue: 35.0731% (minimum 97%, Missing); urinary bladder: 80.3828% (minimum 97%, Missing)",-0.37268,-0.619269,-0.643608,0,4,partial,31.7,31.1,12.3,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 2); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (manageable, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 2); skin: 6.8 nTPM (manageable, limit 5); salivary gland: 6.6 nTPM (protected, limit 2); stomach: 6.1 nTPM (protected, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 4); urinary bladder: 4.1 nTPM (protected, limit 2); lymph node: 3 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140043,PTGR2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.7413% (minimum 75%, Missing); amygdala: 55.6291% (minimum 75%, Missing); basal ganglia: 55.2632% (minimum 75%, Missing); cerebellum: 74.3363% (minimum 75%, Missing); cerebral cortex: 57.3379% (minimum 75%, Missing); choroid plexus: 50.9091% (minimum 75%, Missing); duodenum: 58.7413% (minimum 75%, Missing); heart muscle: 38.8889% (minimum 75%, Missing); hippocampal formation: 59.7865% (minimum 75%, Missing); hypothalamus: 60.2151% (minimum 75%, Missing); kidney: 48.0000% (minimum 75%, Missing); liver: 47.5921% (minimum 75%, Missing); midbrain: 53.5032% (minimum 75%, Missing); parathyroid gland: 62.2222% (minimum 70%, Missing); pituitary gland: 69.4215% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing); skeletal muscle: 34.6392% (minimum 75%, Missing); small intestine: 65.8824% (minimum 75%, Missing); spinal cord: 57.5342% (minimum 75%, Missing); thyroid gland: 57.7320% (minimum 65%, Missing); tongue: 35.0731% (minimum 70%, Missing)",-0.0726804,-0.349269,-0.403608,0,4,partial,31.7,31.1,12.3,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 2); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (manageable, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 2); skin: 6.8 nTPM (manageable, limit 5); salivary gland: 6.6 nTPM (protected, limit 2); stomach: 6.1 nTPM (protected, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 4); urinary bladder: 4.1 nTPM (protected, limit 2); lymph node: 3 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140043,PTGR2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.7413% (minimum 75%, Missing); amygdala: 55.6291% (minimum 75%, Missing); basal ganglia: 55.2632% (minimum 75%, Missing); cerebellum: 74.3363% (minimum 75%, Missing); cerebral cortex: 57.3379% (minimum 75%, Missing); choroid plexus: 50.9091% (minimum 75%, Missing); duodenum: 58.7413% (minimum 75%, Missing); heart muscle: 38.8889% (minimum 75%, Missing); hippocampal formation: 59.7865% (minimum 75%, Missing); hypothalamus: 60.2151% (minimum 75%, Missing); kidney: 48.0000% (minimum 75%, Missing); liver: 47.5921% (minimum 75%, Missing); midbrain: 53.5032% (minimum 75%, Missing); parathyroid gland: 62.2222% (minimum 70%, Missing); pituitary gland: 69.4215% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing); skeletal muscle: 34.6392% (minimum 75%, Missing); small intestine: 65.8824% (minimum 75%, Missing); spinal cord: 57.5342% (minimum 75%, Missing); thyroid gland: 57.7320% (minimum 65%, Missing); tongue: 35.0731% (minimum 70%, Missing)",-0.0726804,-0.349269,-0.403608,0,4,partial,31.7,31.1,12.3,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 3); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (manageable, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 3); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 3); skin: 6.8 nTPM (manageable, limit 5); salivary gland: 6.6 nTPM (protected, limit 3); stomach: 6.1 nTPM (protected, limit 3); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 3); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 4); urinary bladder: 4.1 nTPM (protected, limit 3); smooth muscle: 2.5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140043,PTGR2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.7413% (minimum 75%, Missing); amygdala: 55.6291% (minimum 75%, Missing); basal ganglia: 55.2632% (minimum 75%, Missing); cerebellum: 74.3363% (minimum 75%, Missing); cerebral cortex: 57.3379% (minimum 75%, Missing); choroid plexus: 50.9091% (minimum 75%, Missing); duodenum: 58.7413% (minimum 75%, Missing); heart muscle: 38.8889% (minimum 75%, Missing); hippocampal formation: 59.7865% (minimum 75%, Missing); hypothalamus: 60.2151% (minimum 75%, Missing); kidney: 48.0000% (minimum 75%, Missing); liver: 47.5921% (minimum 75%, Missing); midbrain: 53.5032% (minimum 75%, Missing); parathyroid gland: 62.2222% (minimum 70%, Missing); pituitary gland: 69.4215% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing); skeletal muscle: 34.6392% (minimum 75%, Missing); small intestine: 65.8824% (minimum 75%, Missing); spinal cord: 57.5342% (minimum 75%, Missing); thyroid gland: 57.7320% (minimum 65%, Missing); tongue: 35.0731% (minimum 70%, Missing)",-0.0726804,-0.349269,-0.403608,0,4,partial,31.7,31.1,12.3,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 3); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (manageable, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 3); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 3); skin: 6.8 nTPM (manageable, limit 5); salivary gland: 6.6 nTPM (protected, limit 3); stomach: 6.1 nTPM (protected, limit 3); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 3); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 4); urinary bladder: 4.1 nTPM (protected, limit 3); smooth muscle: 2.5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140043,PTGR2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.7413% (minimum 75%, Baseline (adaptation disabled)); amygdala: 55.6291% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.2632% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.3363% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.3379% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 50.9091% (minimum 75%, Baseline (adaptation disabled)); duodenum: 58.7413% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 38.8889% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 59.7865% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.2151% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 47.5921% (minimum 75%, Baseline (adaptation disabled)); midbrain: 53.5032% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.2222% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.4215% (minimum 75%, Baseline (adaptation disabled)); retina: 61.5385% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 34.6392% (minimum 75%, Baseline (adaptation disabled)); small intestine: 65.8824% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.5342% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 57.7320% (minimum 65%, Baseline (adaptation disabled)); tongue: 35.0731% (minimum 70%, Baseline (adaptation disabled))",-0.0726804,-0.349269,-0.403608,0,4,partial,31.7,31.1,12.3,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 3); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (manageable, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 3); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 3); skin: 6.8 nTPM (manageable, limit 5); adipose tissue: 6.7 nTPM (manageable, limit 5); salivary gland: 6.6 nTPM (protected, limit 3); stomach: 6.1 nTPM (protected, limit 3); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 3); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); urinary bladder: 4.1 nTPM (protected, limit 3); smooth muscle: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140043,PTGR2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.7336% (minimum 95%, Enhanced); amygdala: 92.1569% (minimum 99%, Missing); basal ganglia: 85.7664% (minimum 99%, Missing); bone marrow: 94.3775% (minimum 95%, Enhanced); cerebral cortex: 94.3775% (minimum 95%, Enhanced); choroid plexus: 57.0388% (minimum 99%, Missing); colon: 92.1569% (minimum 97%, Missing); duodenum: 92.8854% (minimum 99%, Missing); hippocampal formation: 86.7159% (minimum 99%, Missing); hypothalamus: 81.5972% (minimum 99%, Missing); kidney: 84.5324% (minimum 99%, Missing); liver: 94.0000% (minimum 95%, Enhanced); lung: 85.7664% (minimum 99%, Missing); midbrain: 95.1417% (minimum 99%, Missing); pancreas: 91.7969% (minimum 99%, Missing); parathyroid gland: 77.8146% (minimum 80%, Enhanced); pituitary gland: 82.4561% (minimum 99%, Missing); rectum: 94.0000% (minimum 97%, Missing); retina: 89.3536% (minimum 99%, Missing); small intestine: 95.1417% (minimum 99%, Missing); spinal cord: 93.6255% (minimum 99%, Missing); spleen: 88.0150% (minimum 95%, Missing); stomach: 90.0383% (minimum 97%, Missing)",-0.0698502,-0.0696169,-0.419612,0,13,partial,17.7,6.7,5.4,"choroid plexus: 17.7 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140057,AK7,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 57.0388% (minimum 75%, Missing)",0.23015,0.200383,-0.179612,0,13,partial,17.7,6.7,5.4,"choroid plexus: 17.7 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140057,AK7,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 57.0388% (minimum 75%, Missing)",0.23015,0.200383,-0.179612,0,13,partial,17.7,6.7,5.4,"choroid plexus: 17.7 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140057,AK7,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 57.0388% (minimum 75%, Missing)",0.23015,0.200383,-0.179612,0,13,partial,17.7,6.7,5.4,"choroid plexus: 17.7 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140057,AK7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 57.0388% (minimum 75%, Baseline (adaptation disabled))",0.163149,0.0781457,-0.179612,0,13,partial,17.7,6.7,5.4,"choroid plexus: 17.7 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 3); skin: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140057,AK7,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 70.0665% (minimum 99%, Missing); basal ganglia: 76.1446% (minimum 99%, Missing); cerebellum: 91.0663% (minimum 95%, Enhanced); cerebral cortex: 72.8111% (minimum 95%, Enhanced); choroid plexus: 94.0476% (minimum 99%, Missing); hippocampal formation: 78.0247% (minimum 99%, Missing); hypothalamus: 77.4510% (minimum 99%, Missing); midbrain: 79.5970% (minimum 99%, Missing); pituitary gland: 93.4911% (minimum 99%, Missing); skeletal muscle: 92.1283% (minimum 95%, Enhanced); spinal cord: 87.7778% (minimum 99%, Missing)",0.05,0.03,-0.289335,0,2,partial,13.5,0,1.1,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 6); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140067,FAM181A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 70.0665% (minimum 75%, Missing)",0.35,0.3,-0.0493348,0,2,partial,13.5,0,1.1,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 6); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140067,FAM181A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 70.0665% (minimum 75%, Missing)",0.35,0.3,-0.0493348,0,2,partial,13.5,0,1.1,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 6); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140067,FAM181A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 70.0665% (minimum 75%, Missing)",0.35,0.3,-0.0493348,0,2,partial,13.5,0,1.1,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 6); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140067,FAM181A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 70.0665% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.8111% (minimum 75%, Baseline (adaptation disabled))",0.316361,0.3,-0.0493348,0,2,partial,13.5,0,1.1,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140067,FAM181A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 25.6410% (minimum 99%, Missing); basal ganglia: 20.4082% (minimum 99%, Missing); bone marrow: 22.2222% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 17.5439% (minimum 99%, Missing); choroid plexus: 2.1834% (minimum 99%, Missing); colon: 83.3333% (minimum 97%, Missing); duodenum: 83.3333% (minimum 99%, Missing); esophagus: 90.9091% (minimum 97%, Missing); heart muscle: 83.3333% (minimum 99%, Missing); hippocampal formation: 35.7143% (minimum 99%, Missing); hypothalamus: 32.2581% (minimum 99%, Missing); liver: 90.9091% (minimum 99%, Missing); lung: 58.8235% (minimum 99%, Missing); lymph node: 47.6190% (minimum 97%, Missing); midbrain: 16.3934% (minimum 99%, Missing); pancreas: 90.9091% (minimum 99%, Missing); pituitary gland: 43.4783% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 7.6923% (minimum 99%, Missing); salivary gland: 90.9091% (minimum 97%, Missing); skeletal muscle: 55.5556% (minimum 99%, Missing); skin: 90.9091% (minimum 95%, Missing); small intestine: 76.9231% (minimum 99%, Missing); smooth muscle: 71.4286% (minimum 99%, Missing); spinal cord: 30.3030% (minimum 99%, Missing); spleen: 27.7778% (minimum 95%, Missing); stomach: 90.9091% (minimum 97%, Missing); thymus: 71.4286% (minimum 95%, Missing); thyroid gland: 90.9091% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 76.9231% (minimum 97%, Missing)",-0.672222,-0.49381,-0.968166,0,80,unavailable,44.8,1.1,2.6,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140090,SLC24A4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 25.6410% (minimum 75%, Missing); basal ganglia: 20.4082% (minimum 75%, Missing); bone marrow: 22.2222% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 17.5439% (minimum 75%, Missing); choroid plexus: 2.1834% (minimum 75%, Missing); hippocampal formation: 35.7143% (minimum 75%, Missing); hypothalamus: 32.2581% (minimum 75%, Missing); lung: 58.8235% (minimum 75%, Missing); lymph node: 47.6190% (minimum 70%, Missing); midbrain: 16.3934% (minimum 75%, Missing); pituitary gland: 43.4783% (minimum 75%, Missing); retina: 7.6923% (minimum 75%, Missing); skeletal muscle: 55.5556% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing); spinal cord: 30.3030% (minimum 75%, Missing); spleen: 27.7778% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing)",-0.372222,-0.22381,-0.728166,0,80,unavailable,44.8,1.1,2.6,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140090,SLC24A4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 25.6410% (minimum 75%, Missing); basal ganglia: 20.4082% (minimum 75%, Missing); bone marrow: 22.2222% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 17.5439% (minimum 75%, Missing); choroid plexus: 2.1834% (minimum 75%, Missing); hippocampal formation: 35.7143% (minimum 75%, Missing); hypothalamus: 32.2581% (minimum 75%, Missing); lung: 58.8235% (minimum 75%, Missing); lymph node: 47.6190% (minimum 70%, Missing); midbrain: 16.3934% (minimum 75%, Missing); pituitary gland: 43.4783% (minimum 75%, Missing); retina: 7.6923% (minimum 75%, Missing); skeletal muscle: 55.5556% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing); spinal cord: 30.3030% (minimum 75%, Missing); spleen: 27.7778% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing)",-0.372222,-0.22381,-0.728166,0,80,unavailable,44.8,1.1,2.6,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140090,SLC24A4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 25.6410% (minimum 75%, Missing); basal ganglia: 20.4082% (minimum 75%, Missing); bone marrow: 22.2222% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 17.5439% (minimum 75%, Missing); choroid plexus: 2.1834% (minimum 75%, Missing); hippocampal formation: 35.7143% (minimum 75%, Missing); hypothalamus: 32.2581% (minimum 75%, Missing); lung: 58.8235% (minimum 75%, Missing); lymph node: 47.6190% (minimum 70%, Missing); midbrain: 16.3934% (minimum 75%, Missing); pituitary gland: 43.4783% (minimum 75%, Missing); retina: 7.6923% (minimum 75%, Missing); skeletal muscle: 55.5556% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing); spinal cord: 30.3030% (minimum 75%, Missing); spleen: 27.7778% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing)",-0.372222,-0.22381,-0.728166,0,80,unavailable,44.8,1.1,2.6,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140090,SLC24A4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 25.6410% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 20.4082% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 22.2222% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 17.5439% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 2.1834% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 35.7143% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 32.2581% (minimum 75%, Baseline (adaptation disabled)); lung: 58.8235% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.6190% (minimum 70%, Baseline (adaptation disabled)); midbrain: 16.3934% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 43.4783% (minimum 75%, Baseline (adaptation disabled)); retina: 7.6923% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 55.5556% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 30.3030% (minimum 75%, Baseline (adaptation disabled)); spleen: 27.7778% (minimum 65%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 70%, Baseline (adaptation disabled))",-0.372222,-0.22381,-0.728166,0,80,unavailable,44.8,1.1,2.6,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140090,SLC24A4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.1917% (minimum 95%, Uncertain); adrenal gland: 86.5517% (minimum 99%, Missing); amygdala: 80.7074% (minimum 99%, Missing); basal ganglia: 78.4375% (minimum 99%, Missing); bone marrow: 48.6434% (minimum 99%, Missing); cerebellum: 76.5244% (minimum 99%, Uncertain); cerebral cortex: 75.6024% (minimum 99%, Missing); choroid plexus: 91.6058% (minimum 99%, Missing); colon: 82.5658% (minimum 97%, Missing); duodenum: 77.9503% (minimum 99%, Missing); esophagus: 57.8341% (minimum 97%, Uncertain); heart muscle: 77.9503% (minimum 99%, Uncertain); hippocampal formation: 79.4304% (minimum 99%, Missing); hypothalamus: 79.4304% (minimum 99%, Missing); kidney: 62.1287% (minimum 99%, Uncertain); liver: 86.8512% (minimum 99%, Uncertain); lung: 74.0413% (minimum 99%, Missing); lymph node: 71.9198% (minimum 97%, Missing); midbrain: 78.1931% (minimum 99%, Missing); pancreas: 88.0702% (minimum 99%, Missing); parathyroid gland: 89.3238% (minimum 97%, Uncertain); pituitary gland: 82.0261% (minimum 99%, Missing); rectum: 80.9677% (minimum 97%, Missing); retina: 45.4710% (minimum 99%, Missing); salivary gland: 80.1917% (minimum 97%, Missing); skeletal muscle: 71.1048% (minimum 99%, Uncertain); skin: 76.9939% (minimum 95%, Uncertain); small intestine: 74.0413% (minimum 99%, Missing); smooth muscle: 84.2282% (minimum 99%, Uncertain); spinal cord: 74.7024% (minimum 99%, Missing); spleen: 66.7553% (minimum 95%, Uncertain); stomach: 79.4304% (minimum 97%, Missing); thymus: 62.4378% (minimum 95%, Missing); thyroid gland: 74.2604% (minimum 95%, Missing); tongue: 70.5056% (minimum 97%, Missing); urinary bladder: 75.8308% (minimum 97%, Missing)",-0.325622,-0.391659,-0.53529,0,3,partial,30.1,18.3,15.1,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 2); kidney: 15.3 nTPM (vital, limit 1); thymus: 15.1 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); tongue: 10.5 nTPM (protected, limit 2); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 2); lung: 8.8 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 2); cerebellum: 7.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); salivary gland: 6.2 nTPM (protected, limit 2); adipose tissue: 6.2 nTPM (manageable, limit 5); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140199,SLC12A6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 48.6434% (minimum 75%, Missing); esophagus: 57.8341% (minimum 70%, Uncertain); kidney: 62.1287% (minimum 75%, Uncertain); lung: 74.0413% (minimum 75%, Missing); retina: 45.4710% (minimum 75%, Missing); skeletal muscle: 71.1048% (minimum 75%, Uncertain); small intestine: 74.0413% (minimum 75%, Missing); spinal cord: 74.7024% (minimum 75%, Missing); thymus: 62.4378% (minimum 65%, Missing)",-0.0256219,-0.121659,-0.29529,0,3,partial,30.1,18.3,15.1,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 2); kidney: 15.3 nTPM (vital, limit 1); thymus: 15.1 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); tongue: 10.5 nTPM (protected, limit 2); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 2); lung: 8.8 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 2); cerebellum: 7.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); salivary gland: 6.2 nTPM (protected, limit 2); adipose tissue: 6.2 nTPM (manageable, limit 5); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140199,SLC12A6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 48.6434% (minimum 75%, Missing); esophagus: 57.8341% (minimum 70%, Uncertain); kidney: 62.1287% (minimum 75%, Uncertain); lung: 74.0413% (minimum 75%, Missing); retina: 45.4710% (minimum 75%, Missing); skeletal muscle: 71.1048% (minimum 75%, Uncertain); small intestine: 74.0413% (minimum 75%, Missing); spinal cord: 74.7024% (minimum 75%, Missing); thymus: 62.4378% (minimum 65%, Missing)",-0.0256219,-0.121659,-0.29529,0,3,partial,30.1,18.3,15.1,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 3); kidney: 15.3 nTPM (vital, limit 1); thymus: 15.1 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); tongue: 10.5 nTPM (protected, limit 3); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 3); small intestine: 8.8 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 3); cerebellum: 7.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); hippocampal formation: 6.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); adipose tissue: 6.2 nTPM (manageable, limit 5); salivary gland: 6.2 nTPM (protected, limit 3); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140199,SLC12A6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 48.6434% (minimum 75%, Missing); esophagus: 57.8341% (minimum 70%, Uncertain); kidney: 62.1287% (minimum 75%, Uncertain); lung: 74.0413% (minimum 75%, Missing); retina: 45.4710% (minimum 75%, Missing); skeletal muscle: 71.1048% (minimum 75%, Uncertain); small intestine: 74.0413% (minimum 75%, Missing); spinal cord: 74.7024% (minimum 75%, Missing); thymus: 62.4378% (minimum 65%, Missing)",-0.0256219,-0.121659,-0.29529,0,3,partial,30.1,18.3,15.1,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 3); kidney: 15.3 nTPM (vital, limit 1); thymus: 15.1 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); tongue: 10.5 nTPM (protected, limit 3); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 3); small intestine: 8.8 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 3); cerebellum: 7.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); hippocampal formation: 6.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); adipose tissue: 6.2 nTPM (manageable, limit 5); salivary gland: 6.2 nTPM (protected, limit 3); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140199,SLC12A6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 48.6434% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.8341% (minimum 70%, Baseline (adaptation disabled)); kidney: 62.1287% (minimum 75%, Baseline (adaptation disabled)); lung: 74.0413% (minimum 75%, Baseline (adaptation disabled)); retina: 45.4710% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 71.1048% (minimum 75%, Baseline (adaptation disabled)); small intestine: 74.0413% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.7024% (minimum 75%, Baseline (adaptation disabled)); thymus: 62.4378% (minimum 65%, Baseline (adaptation disabled))",-0.0256219,-0.121659,-0.29529,0,3,partial,30.1,18.3,15.1,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 3); kidney: 15.3 nTPM (vital, limit 1); thymus: 15.1 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); tongue: 10.5 nTPM (protected, limit 3); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 3); small intestine: 8.8 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 3); cerebellum: 7.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); hippocampal formation: 6.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); adipose tissue: 6.2 nTPM (manageable, limit 5); salivary gland: 6.2 nTPM (protected, limit 3); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140199,SLC12A6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.4118% (minimum 95%, Missing); adrenal gland: 71.0526% (minimum 99%, Missing); amygdala: 57.4468% (minimum 99%, Missing); basal ganglia: 60.0000% (minimum 99%, Missing); bone marrow: 81.8182% (minimum 99%, Missing); cerebellum: 90.0000% (minimum 99%, Missing); cerebral cortex: 62.7907% (minimum 99%, Missing); choroid plexus: 56.2500% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 84.3750% (minimum 99%, Missing); esophagus: 57.4468% (minimum 97%, Missing); heart muscle: 69.2308% (minimum 99%, Missing); hippocampal formation: 65.8537% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 72.9730% (minimum 99%, Missing); liver: 26.7327% (minimum 99%, Missing); lung: 65.8537% (minimum 99%, Missing); lymph node: 84.3750% (minimum 97%, Missing); midbrain: 77.1429% (minimum 99%, Missing); pancreas: 36.0000% (minimum 99%, Missing); parathyroid gland: 93.1034% (minimum 97%, Missing); pituitary gland: 69.2308% (minimum 99%, Missing); rectum: 87.0968% (minimum 97%, Missing); retina: 79.4118% (minimum 99%, Missing); salivary gland: 51.9231% (minimum 97%, Missing); skeletal muscle: 33.3333% (minimum 99%, Missing); skin: 56.2500% (minimum 95%, Missing); small intestine: 71.0526% (minimum 99%, Missing); smooth muscle: 84.3750% (minimum 99%, Missing); spinal cord: 81.8182% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 72.9730% (minimum 97%, Missing); thymus: 20.6107% (minimum 95%, Missing); thyroid gland: 79.4118% (minimum 95%, Missing); tongue: 96.4286% (minimum 97%, Missing); urinary bladder: 62.7907% (minimum 97%, Missing)",-0.743893,-0.450769,-0.722673,0,80,unavailable,7.4,2.5,10.4,"thymus: 10.4 nTPM (manageable, limit 5); liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140470,ADAMTS17,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.0526% (minimum 75%, Missing); amygdala: 57.4468% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); choroid plexus: 56.2500% (minimum 75%, Missing); esophagus: 57.4468% (minimum 70%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 65.8537% (minimum 75%, Missing); kidney: 72.9730% (minimum 75%, Missing); liver: 26.7327% (minimum 75%, Missing); lung: 65.8537% (minimum 75%, Missing); pancreas: 36.0000% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); salivary gland: 51.9231% (minimum 70%, Missing); skeletal muscle: 33.3333% (minimum 75%, Missing); skin: 56.2500% (minimum 65%, Missing); small intestine: 71.0526% (minimum 75%, Missing); thymus: 20.6107% (minimum 65%, Missing); urinary bladder: 62.7907% (minimum 70%, Missing)",-0.443893,-0.180769,-0.482673,0,80,unavailable,7.4,2.5,10.4,"thymus: 10.4 nTPM (manageable, limit 5); liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140470,ADAMTS17,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.0526% (minimum 75%, Missing); amygdala: 57.4468% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); choroid plexus: 56.2500% (minimum 75%, Missing); esophagus: 57.4468% (minimum 70%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 65.8537% (minimum 75%, Missing); kidney: 72.9730% (minimum 75%, Missing); liver: 26.7327% (minimum 75%, Missing); lung: 65.8537% (minimum 75%, Missing); pancreas: 36.0000% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); salivary gland: 51.9231% (minimum 70%, Missing); skeletal muscle: 33.3333% (minimum 75%, Missing); skin: 56.2500% (minimum 65%, Missing); small intestine: 71.0526% (minimum 75%, Missing); thymus: 20.6107% (minimum 65%, Missing); urinary bladder: 62.7907% (minimum 70%, Missing)",-0.443893,-0.180769,-0.482673,0,80,unavailable,7.4,2.5,10.4,"thymus: 10.4 nTPM (manageable, limit 5); liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140470,ADAMTS17,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.0526% (minimum 75%, Missing); amygdala: 57.4468% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); choroid plexus: 56.2500% (minimum 75%, Missing); esophagus: 57.4468% (minimum 70%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 65.8537% (minimum 75%, Missing); kidney: 72.9730% (minimum 75%, Missing); liver: 26.7327% (minimum 75%, Missing); lung: 65.8537% (minimum 75%, Missing); pancreas: 36.0000% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); salivary gland: 51.9231% (minimum 70%, Missing); skeletal muscle: 33.3333% (minimum 75%, Missing); skin: 56.2500% (minimum 65%, Missing); small intestine: 71.0526% (minimum 75%, Missing); thymus: 20.6107% (minimum 65%, Missing); urinary bladder: 62.7907% (minimum 70%, Missing)",-0.443893,-0.180769,-0.482673,0,80,unavailable,7.4,2.5,10.4,"thymus: 10.4 nTPM (manageable, limit 5); liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140470,ADAMTS17,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.0526% (minimum 75%, Baseline (adaptation disabled)); amygdala: 57.4468% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.7907% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 56.2500% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.4468% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.2308% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.8537% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.9730% (minimum 75%, Baseline (adaptation disabled)); liver: 26.7327% (minimum 75%, Baseline (adaptation disabled)); lung: 65.8537% (minimum 75%, Baseline (adaptation disabled)); pancreas: 36.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 69.2308% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.9231% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 33.3333% (minimum 75%, Baseline (adaptation disabled)); skin: 56.2500% (minimum 65%, Baseline (adaptation disabled)); small intestine: 71.0526% (minimum 75%, Baseline (adaptation disabled)); thymus: 20.6107% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 62.7907% (minimum 70%, Baseline (adaptation disabled))",-0.443893,-0.180769,-0.482673,0,80,unavailable,7.4,2.5,10.4,"thymus: 10.4 nTPM (manageable, limit 5); liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140470,ADAMTS17,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 94.3548% (minimum 97%, Supported)",0.05,0.03,-0.0264516,0,1,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140478,GOLGA6D,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140478,GOLGA6D,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140478,GOLGA6D,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140478,GOLGA6D,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.193548,0,1,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140478,GOLGA6D,current_fixed,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 94.9153% (minimum 99%, Missing); basal ganglia: 91.0569% (minimum 99%, Missing); bone marrow: 97.3913% (minimum 99%, Missing); cerebellum: 94.9153% (minimum 99%, Missing); cerebral cortex: 98.2456% (minimum 99%, Missing); choroid plexus: 62.2222% (minimum 99%, Missing); heart muscle: 91.0569% (minimum 99%, Missing); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 92.5620% (minimum 99%, Missing); kidney: 92.5620% (minimum 99%, Missing); lung: 92.5620% (minimum 99%, Missing); midbrain: 98.2456% (minimum 99%, Missing); pancreas: 94.9153% (minimum 99%, Missing); parathyroid gland: 95.7265% (minimum 97%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); retina: 80.5755% (minimum 99%, Missing); skeletal muscle: 97.3913% (minimum 99%, Missing); spinal cord: 98.2456% (minimum 99%, Missing); thyroid gland: 86.8217% (minimum 95%, Missing)",-0.0817829,-0.012735,-0.367778,0,80,unavailable,6.8,0.5,1.7,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140527,WDR93,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 62.2222% (minimum 75%, Missing)",0.218217,0.257265,-0.127778,0,80,unavailable,6.8,0.5,1.7,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140527,WDR93,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 62.2222% (minimum 75%, Missing)",0.218217,0.257265,-0.127778,0,80,unavailable,6.8,0.5,1.7,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140527,WDR93,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 62.2222% (minimum 75%, Missing)",0.218217,0.257265,-0.127778,0,80,unavailable,6.8,0.5,1.7,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140527,WDR93,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 62.2222% (minimum 75%, Baseline (adaptation disabled))",0.218217,0.257265,-0.127778,0,80,unavailable,6.8,0.5,1.7,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140527,WDR93,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 82.3529% (minimum 95%, Missing); adrenal gland: 93.3333% (minimum 99%, Missing); amygdala: 93.3333% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); bone marrow: 29.1667% (minimum 99%, Missing); cerebral cortex: 87.5000% (minimum 99%, Missing); colon: 63.6364% (minimum 97%, Missing); duodenum: 58.3333% (minimum 99%, Missing); esophagus: 25.4545% (minimum 97%, Missing); heart muscle: 93.3333% (minimum 99%, Missing); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 93.3333% (minimum 99%, Missing); kidney: 93.3333% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); lung: 87.5000% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 93.3333% (minimum 99%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); rectum: 56.0000% (minimum 97%, Missing); retina: 93.3333% (minimum 99%, Missing); salivary gland: 73.6842% (minimum 97%, Missing); skin: 73.6842% (minimum 95%, Missing); small intestine: 60.8696% (minimum 99%, Missing); smooth muscle: 87.5000% (minimum 99%, Missing); spleen: 73.6842% (minimum 95%, Missing); stomach: 77.7778% (minimum 97%, Missing); thymus: 25.9259% (minimum 95%, Missing); thyroid gland: 93.3333% (minimum 95%, Missing); urinary bladder: 82.3529% (minimum 97%, Missing)",-0.690741,-0.715455,-0.698333,0,80,unavailable,3.4,4.1,4,"esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140534,TICRR,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 29.1667% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 58.3333% (minimum 75%, Missing); esophagus: 25.4545% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); rectum: 56.0000% (minimum 70%, Missing); small intestine: 60.8696% (minimum 75%, Missing); thymus: 25.9259% (minimum 65%, Missing)",-0.390741,-0.445455,-0.458333,0,80,unavailable,3.4,4.1,4,"esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140534,TICRR,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 29.1667% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 58.3333% (minimum 75%, Missing); esophagus: 25.4545% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); rectum: 56.0000% (minimum 70%, Missing); small intestine: 60.8696% (minimum 75%, Missing); thymus: 25.9259% (minimum 65%, Missing)",-0.390741,-0.445455,-0.458333,0,80,unavailable,3.4,4.1,4,"esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140534,TICRR,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 29.1667% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 58.3333% (minimum 75%, Missing); esophagus: 25.4545% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); rectum: 56.0000% (minimum 70%, Missing); small intestine: 60.8696% (minimum 75%, Missing); thymus: 25.9259% (minimum 65%, Missing)",-0.390741,-0.445455,-0.458333,0,80,unavailable,3.4,4.1,4,"esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140534,TICRR,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 29.1667% (minimum 75%, Baseline (adaptation disabled)); colon: 63.6364% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.3333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 25.4545% (minimum 70%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); rectum: 56.0000% (minimum 70%, Baseline (adaptation disabled)); small intestine: 60.8696% (minimum 75%, Baseline (adaptation disabled)); thymus: 25.9259% (minimum 65%, Baseline (adaptation disabled))",-0.390741,-0.445455,-0.458333,0,80,unavailable,3.4,4.1,4,"esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140534,TICRR,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 96.8750% (minimum 99%, Missing)",0.05,0.03,-0.02125,0,80,unavailable,3.1,0,0,"cerebellum: 3.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140623,SEPTIN12,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.21875,0,80,unavailable,3.1,0,0,"cerebellum: 3.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140623,SEPTIN12,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.21875,0,80,unavailable,3.1,0,0,"cerebellum: 3.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140623,SEPTIN12,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.21875,0,80,unavailable,3.1,0,0,"cerebellum: 3.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140623,SEPTIN12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.21875,0,80,unavailable,3.1,0,0,"cerebellum: 3.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140623,SEPTIN12,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 93.3333% (minimum 99%, Missing); cerebellum: 96.5517% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); hippocampal formation: 77.7778% (minimum 99%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing)",0.05,0.03,-0.323333,0,80,unavailable,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140798,ABCC12,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 66.6667% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.0833333,0,80,unavailable,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140798,ABCC12,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 66.6667% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.0833333,0,80,unavailable,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140798,ABCC12,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 66.6667% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.0833333,0,80,unavailable,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140798,ABCC12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.0833333,0,80,unavailable,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140798,ABCC12,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0477859,0.0296831,0.00810157,0,80,unavailable,1.2,0.2,1.4,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140932,CMTM2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347786,0.299683,0.248102,0,80,unavailable,1.2,0.2,1.4,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140932,CMTM2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347786,0.299683,0.248102,0,80,unavailable,1.2,0.2,1.4,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140932,CMTM2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347786,0.299683,0.248102,0,80,unavailable,1.2,0.2,1.4,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140932,CMTM2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347786,0.299683,0.248102,0,80,unavailable,1.2,0.2,1.4,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140932,CMTM2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.5194% (minimum 99%, Missing); basal ganglia: 96.7692% (minimum 99%, Missing); hippocampal formation: 98.5893% (minimum 99%, Missing)",0.0421136,0.0268304,-0.0223077,0,10,partial,2.1,0.7,3.6,"basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140955,ADAD2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342114,0.29683,0.217692,0,10,partial,2.1,0.7,3.6,"basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140955,ADAD2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342114,0.29683,0.217692,0,10,partial,2.1,0.7,3.6,"basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140955,ADAD2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342114,0.29683,0.217692,0,10,partial,2.1,0.7,3.6,"basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140955,ADAD2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.295865,0.288994,0.217692,0,10,partial,2.1,0.7,3.6,"basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140955,ADAD2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Uncertain); adrenal gland: 73.1343% (minimum 99%, Missing); amygdala: 68.0556% (minimum 99%, Missing); basal ganglia: 68.0556% (minimum 99%, Missing); bone marrow: 92.4528% (minimum 99%, Missing); cerebellum: 60.4938% (minimum 99%, Missing); cerebral cortex: 67.1233% (minimum 99%, Uncertain); choroid plexus: 50.7772% (minimum 99%, Missing); colon: 67.1233% (minimum 97%, Missing); duodenum: 83.7607% (minimum 99%, Missing); esophagus: 81.6667% (minimum 97%, Missing); heart muscle: 65.3333% (minimum 99%, Missing); hippocampal formation: 68.0556% (minimum 99%, Missing); hypothalamus: 65.3333% (minimum 99%, Missing); kidney: 62.8205% (minimum 99%, Missing); liver: 76.5625% (minimum 99%, Missing); lung: 77.1654% (minimum 99%, Missing); lymph node: 71.0145% (minimum 97%, Missing); midbrain: 68.5315% (minimum 99%, Missing); pancreas: 75.9690% (minimum 99%, Missing); parathyroid gland: 60.8696% (minimum 97%, Missing); pituitary gland: 55.3672% (minimum 99%, Missing); rectum: 84.4828% (minimum 97%, Missing); retina: 55.0562% (minimum 99%, Missing); salivary gland: 79.0323% (minimum 97%, Missing); skeletal muscle: 71.0145% (minimum 99%, Missing); skin: 79.6748% (minimum 95%, Missing); small intestine: 78.4000% (minimum 99%, Missing); smooth muscle: 74.8092% (minimum 99%, Missing); spinal cord: 68.0556% (minimum 99%, Missing); spleen: 67.5862% (minimum 95%, Uncertain); stomach: 79.0323% (minimum 97%, Missing); thymus: 73.1343% (minimum 95%, Missing); thyroid gland: 58.3333% (minimum 95%, Missing); tongue: 66.2162% (minimum 97%, Missing); urinary bladder: 71.5328% (minimum 97%, Missing)",-0.366667,-0.361304,-0.482228,0,3,partial,9.5,6.3,7,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (manageable, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); kidney: 5.8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); colon: 4.8 nTPM (protected, limit 2); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); lymph node: 4 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140993,TIGD7,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.1343% (minimum 75%, Missing); amygdala: 68.0556% (minimum 75%, Missing); basal ganglia: 68.0556% (minimum 75%, Missing); cerebellum: 60.4938% (minimum 75%, Missing); cerebral cortex: 67.1233% (minimum 75%, Uncertain); choroid plexus: 50.7772% (minimum 75%, Missing); colon: 67.1233% (minimum 70%, Missing); heart muscle: 65.3333% (minimum 75%, Missing); hippocampal formation: 68.0556% (minimum 75%, Missing); hypothalamus: 65.3333% (minimum 75%, Missing); kidney: 62.8205% (minimum 75%, Missing); midbrain: 68.5315% (minimum 75%, Missing); parathyroid gland: 60.8696% (minimum 70%, Missing); pituitary gland: 55.3672% (minimum 75%, Missing); retina: 55.0562% (minimum 75%, Missing); skeletal muscle: 71.0145% (minimum 75%, Missing); smooth muscle: 74.8092% (minimum 75%, Missing); spinal cord: 68.0556% (minimum 75%, Missing); thyroid gland: 58.3333% (minimum 65%, Missing); tongue: 66.2162% (minimum 70%, Missing)",-0.0666667,-0.0913043,-0.242228,0,3,partial,9.5,6.3,7,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (manageable, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); kidney: 5.8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); colon: 4.8 nTPM (protected, limit 2); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); lymph node: 4 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140993,TIGD7,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.1343% (minimum 75%, Missing); amygdala: 68.0556% (minimum 75%, Missing); basal ganglia: 68.0556% (minimum 75%, Missing); cerebellum: 60.4938% (minimum 75%, Missing); cerebral cortex: 67.1233% (minimum 75%, Uncertain); choroid plexus: 50.7772% (minimum 75%, Missing); colon: 67.1233% (minimum 70%, Missing); heart muscle: 65.3333% (minimum 75%, Missing); hippocampal formation: 68.0556% (minimum 75%, Missing); hypothalamus: 65.3333% (minimum 75%, Missing); kidney: 62.8205% (minimum 75%, Missing); midbrain: 68.5315% (minimum 75%, Missing); parathyroid gland: 60.8696% (minimum 70%, Missing); pituitary gland: 55.3672% (minimum 75%, Missing); retina: 55.0562% (minimum 75%, Missing); skeletal muscle: 71.0145% (minimum 75%, Missing); smooth muscle: 74.8092% (minimum 75%, Missing); spinal cord: 68.0556% (minimum 75%, Missing); thyroid gland: 58.3333% (minimum 65%, Missing); tongue: 66.2162% (minimum 70%, Missing)",-0.0666667,-0.0913043,-0.242228,0,3,partial,9.5,6.3,7,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (manageable, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); kidney: 5.8 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); colon: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); lymph node: 4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140993,TIGD7,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.1343% (minimum 75%, Missing); amygdala: 68.0556% (minimum 75%, Missing); basal ganglia: 68.0556% (minimum 75%, Missing); cerebellum: 60.4938% (minimum 75%, Missing); cerebral cortex: 67.1233% (minimum 75%, Uncertain); choroid plexus: 50.7772% (minimum 75%, Missing); colon: 67.1233% (minimum 70%, Missing); heart muscle: 65.3333% (minimum 75%, Missing); hippocampal formation: 68.0556% (minimum 75%, Missing); hypothalamus: 65.3333% (minimum 75%, Missing); kidney: 62.8205% (minimum 75%, Missing); midbrain: 68.5315% (minimum 75%, Missing); parathyroid gland: 60.8696% (minimum 70%, Missing); pituitary gland: 55.3672% (minimum 75%, Missing); retina: 55.0562% (minimum 75%, Missing); skeletal muscle: 71.0145% (minimum 75%, Missing); smooth muscle: 74.8092% (minimum 75%, Missing); spinal cord: 68.0556% (minimum 75%, Missing); thyroid gland: 58.3333% (minimum 65%, Missing); tongue: 66.2162% (minimum 70%, Missing)",-0.0666667,-0.0913043,-0.242228,0,3,partial,9.5,6.3,7,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (manageable, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); kidney: 5.8 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); colon: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); lymph node: 4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140993,TIGD7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.1343% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.0556% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 68.0556% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.4938% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 67.1233% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 50.7772% (minimum 75%, Baseline (adaptation disabled)); colon: 67.1233% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.3333% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.0556% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.3333% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.8205% (minimum 75%, Baseline (adaptation disabled)); midbrain: 68.5315% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.8696% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.3672% (minimum 75%, Baseline (adaptation disabled)); retina: 55.0562% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 71.0145% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 74.8092% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.0556% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 58.3333% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.2162% (minimum 70%, Baseline (adaptation disabled))",-0.0666667,-0.0913043,-0.242228,0,3,partial,9.5,6.3,7,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (manageable, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); kidney: 5.8 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); colon: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); lymph node: 4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000140993,TIGD7,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
True,compatible,,True,True,True,,0.0478166,0.017041,0.0056427,0,3,partial,1.7,0.6,2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141096,DPEP3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.347817,0.287041,0.245643,0,3,partial,1.7,0.6,2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141096,DPEP3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.347817,0.287041,0.245643,0,3,partial,1.7,0.6,2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141096,DPEP3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.347817,0.287041,0.245643,0,3,partial,1.7,0.6,2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141096,DPEP3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308071,0.287041,0.214135,0,3,partial,1.7,0.6,2,"bone marrow: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141096,DPEP3,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 66.6667% (minimum 99%, Missing); lymph node: 33.3333% (minimum 97%, Missing); pancreas: 66.6667% (minimum 99%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 66.6667% (minimum 95%, Missing); spleen: 40.0000% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); urinary bladder: 66.6667% (minimum 97%, Missing)",-0.55,-0.636667,-0.704286,0,80,unavailable,0.5,0.4,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141194,OR4D1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lymph node: 33.3333% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",-0.25,-0.366667,-0.464286,0,80,unavailable,0.5,0.4,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141194,OR4D1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lymph node: 33.3333% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",-0.25,-0.366667,-0.464286,0,80,unavailable,0.5,0.4,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141194,OR4D1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lymph node: 33.3333% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",-0.25,-0.366667,-0.464286,0,80,unavailable,0.5,0.4,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141194,OR4D1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lymph node: 33.3333% (minimum 70%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 40.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 66.6667% (minimum 70%, Baseline (adaptation disabled))",-0.25,-0.366667,-0.464286,0,80,unavailable,0.5,0.4,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141194,OR4D1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.05,0.03,0.01,0,0,routine_complete,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141200,KIF2B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141200,KIF2B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141200,KIF2B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141200,KIF2B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141200,KIF2B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4411% (minimum 95%, Missing); adrenal gland: 80.0416% (minimum 99%, Missing); amygdala: 82.2650% (minimum 99%, Missing); basal ganglia: 81.5678% (minimum 99%, Missing); bone marrow: 92.5481% (minimum 99%, Missing); cerebellum: 74.7573% (minimum 99%, Missing); cerebral cortex: 79.7101% (minimum 99%, Missing); choroid plexus: 83.8780% (minimum 99%, Missing); colon: 77.4648% (minimum 97%, Missing); duodenum: 79.2181% (minimum 99%, Missing); esophagus: 82.2650% (minimum 97%, Missing); heart muscle: 71.9626% (minimum 99%, Missing); hippocampal formation: 82.9741% (minimum 99%, Missing); hypothalamus: 82.0896% (minimum 99%, Missing); kidney: 76.0870% (minimum 99%, Missing); liver: 80.3758% (minimum 99%, Missing); lung: 81.5678% (minimum 99%, Missing); lymph node: 74.4681% (minimum 97%, Missing); midbrain: 81.5678% (minimum 99%, Missing); pancreas: 81.0526% (minimum 99%, Missing); parathyroid gland: 70.9024% (minimum 97%, Missing); pituitary gland: 78.8934% (minimum 99%, Missing); rectum: 79.8755% (minimum 97%, Missing); retina: 63.3224% (minimum 99%, Missing); salivary gland: 78.8934% (minimum 97%, Missing); skeletal muscle: 62.7036% (minimum 99%, Missing); skin: 82.4411% (minimum 95%, Missing); small intestine: 80.7128% (minimum 99%, Missing); smooth muscle: 76.0870% (minimum 99%, Missing); spinal cord: 82.4411% (minimum 99%, Missing); spleen: 78.7321% (minimum 95%, Missing); stomach: 79.7101% (minimum 97%, Missing); thymus: 69.2446% (minimum 95%, Missing); thyroid gland: 71.4286% (minimum 95%, Missing); tongue: 65.0338% (minimum 97%, Missing); urinary bladder: 81.3953% (minimum 97%, Missing)",-0.257554,-0.319662,-0.362964,0,1,partial,22.9,20.7,17.1,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 2); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 2); thyroid gland: 15.4 nTPM (manageable, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 2); cerebellum: 13 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 2); spleen: 10.4 nTPM (manageable, limit 5); salivary gland: 10.3 nTPM (protected, limit 2); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 2); cerebral cortex: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 2); midbrain: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); esophagus: 8.3 nTPM (protected, limit 2); amygdala: 8.3 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141219,MTNAP1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 74.7573% (minimum 75%, Missing); heart muscle: 71.9626% (minimum 75%, Missing); retina: 63.3224% (minimum 75%, Missing); skeletal muscle: 62.7036% (minimum 75%, Missing); tongue: 65.0338% (minimum 70%, Missing)",0.042446,-0.0496622,-0.122964,0,1,partial,22.9,20.7,17.1,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 2); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 2); thyroid gland: 15.4 nTPM (manageable, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 2); cerebellum: 13 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 2); spleen: 10.4 nTPM (manageable, limit 5); salivary gland: 10.3 nTPM (protected, limit 2); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 2); cerebral cortex: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 2); midbrain: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); esophagus: 8.3 nTPM (protected, limit 2); amygdala: 8.3 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141219,MTNAP1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 74.7573% (minimum 75%, Missing); heart muscle: 71.9626% (minimum 75%, Missing); retina: 63.3224% (minimum 75%, Missing); skeletal muscle: 62.7036% (minimum 75%, Missing); tongue: 65.0338% (minimum 70%, Missing)",0.042446,-0.0496622,-0.122964,0,1,partial,22.9,20.7,17.1,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 3); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 3); thyroid gland: 15.4 nTPM (manageable, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 3); cerebellum: 13 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 3); spleen: 10.4 nTPM (manageable, limit 5); salivary gland: 10.3 nTPM (protected, limit 3); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 3); cerebral cortex: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 3); midbrain: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); esophagus: 8.3 nTPM (protected, limit 3); amygdala: 8.3 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141219,MTNAP1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 74.7573% (minimum 75%, Missing); heart muscle: 71.9626% (minimum 75%, Missing); retina: 63.3224% (minimum 75%, Missing); skeletal muscle: 62.7036% (minimum 75%, Missing); tongue: 65.0338% (minimum 70%, Missing)",0.042446,-0.0496622,-0.122964,0,1,partial,22.9,20.7,17.1,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 3); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 3); thyroid gland: 15.4 nTPM (manageable, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 3); cerebellum: 13 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 3); spleen: 10.4 nTPM (manageable, limit 5); salivary gland: 10.3 nTPM (protected, limit 3); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 3); cerebral cortex: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 3); midbrain: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); esophagus: 8.3 nTPM (protected, limit 3); amygdala: 8.3 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141219,MTNAP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 74.7573% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.9626% (minimum 75%, Baseline (adaptation disabled)); retina: 63.3224% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 62.7036% (minimum 75%, Baseline (adaptation disabled)); tongue: 65.0338% (minimum 70%, Baseline (adaptation disabled))",0.042446,-0.0496622,-0.122964,0,1,partial,22.9,20.7,17.1,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 3); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 3); thyroid gland: 15.4 nTPM (manageable, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 3); cerebellum: 13 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 3); spleen: 10.4 nTPM (manageable, limit 5); salivary gland: 10.3 nTPM (protected, limit 3); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 3); cerebral cortex: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 3); midbrain: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); esophagus: 8.3 nTPM (protected, limit 3); amygdala: 8.3 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141219,MTNAP1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0455437,0.0180584,0.00510022,0,80,unavailable,1.1,2.7,1,"parathyroid gland: 2.7 nTPM (protected, limit 2); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141255,SPATA22,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345544,0.288058,0.2451,0,80,unavailable,1.1,2.7,1,"parathyroid gland: 2.7 nTPM (protected, limit 2); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141255,SPATA22,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345544,0.288058,0.2451,0,80,unavailable,1.1,2.7,1,"midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141255,SPATA22,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345544,0.288058,0.2451,0,80,unavailable,1.1,2.7,1,"midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141255,SPATA22,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345544,0.288058,0.2451,0,80,unavailable,1.1,2.7,1,"midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141255,SPATA22,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.5437% (minimum 99%, Missing); pancreas: 85.7143% (minimum 95%, Enhanced)",0.05,0.03,-0.0928571,0,6,partial,20.3,0.2,0.3,"pancreas: 20.3 nTPM (vital, limit 6); choroid plexus: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141316,SPACA3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.235437,0,6,partial,20.3,0.2,0.3,"pancreas: 20.3 nTPM (vital, limit 6); choroid plexus: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141316,SPACA3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.235437,0,6,partial,20.3,0.2,0.3,"pancreas: 20.3 nTPM (vital, limit 6); choroid plexus: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141316,SPACA3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.235437,0,6,partial,20.3,0.2,0.3,"pancreas: 20.3 nTPM (vital, limit 6); choroid plexus: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141316,SPACA3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347543,0.298361,0.107143,0,6,partial,20.3,0.2,0.3,"pancreas: 20.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141316,SPACA3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0492401,0.03,0.0084814,0,4,partial,0.6,0.1,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141371,CHCT1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34924,0.3,0.248481,0,4,partial,0.6,0.1,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141371,CHCT1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34924,0.3,0.248481,0,4,partial,0.6,0.1,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141371,CHCT1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34924,0.3,0.248481,0,4,partial,0.6,0.1,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141371,CHCT1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346212,0.29924,0.245458,0,4,partial,0.6,0.1,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141371,CHCT1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.2712% (minimum 95%, Uncertain); adrenal gland: 69.2308% (minimum 99%, Missing); amygdala: 95.7447% (minimum 99%, Missing); basal ganglia: 91.8367% (minimum 99%, Missing); bone marrow: 61.6438% (minimum 99%, Uncertain); cerebellum: 86.5385% (minimum 99%, Missing); cerebral cortex: 80.3571% (minimum 99%, Missing); colon: 73.7705% (minimum 97%, Missing); duodenum: 91.8367% (minimum 99%, Missing); esophagus: 81.8182% (minimum 97%, Missing); heart muscle: 93.7500% (minimum 99%, Missing); hippocampal formation: 95.7447% (minimum 99%, Missing); hypothalamus: 93.7500% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 97.8261% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 95.7447% (minimum 99%, Missing); pancreas: 80.3571% (minimum 99%, Missing); parathyroid gland: 88.2353% (minimum 97%, Missing); pituitary gland: 95.7447% (minimum 99%, Missing); rectum: 77.5862% (minimum 97%, Missing); retina: 93.7500% (minimum 99%, Missing); salivary gland: 80.3571% (minimum 97%, Missing); skeletal muscle: 77.5862% (minimum 99%, Missing); skin: 76.2712% (minimum 95%, Uncertain); small intestine: 84.9057% (minimum 99%, Missing); smooth muscle: 80.3571% (minimum 99%, Missing); spinal cord: 95.7447% (minimum 99%, Missing); spleen: 65.2174% (minimum 95%, Uncertain); stomach: 71.4286% (minimum 97%, Missing); thymus: 72.5806% (minimum 95%, Missing); thyroid gland: 72.5806% (minimum 95%, Missing); tongue: 88.2353% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.297826,-0.37,-0.373562,0,0,routine_complete,2.8,3,2.4,"lymph node: 3 nTPM (protected, limit 2); bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141384,TAF4B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.2308% (minimum 75%, Missing); bone marrow: 61.6438% (minimum 75%, Uncertain); lymph node: 60.0000% (minimum 70%, Missing)",0.00217391,-0.1,-0.133562,0,0,routine_complete,2.8,3,2.4,"lymph node: 3 nTPM (protected, limit 2); bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141384,TAF4B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.2308% (minimum 75%, Missing); bone marrow: 61.6438% (minimum 75%, Uncertain); lymph node: 60.0000% (minimum 70%, Missing)",0.00217391,-0.1,-0.133562,0,0,routine_complete,2.8,3,2.4,"bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141384,TAF4B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.2308% (minimum 75%, Missing); bone marrow: 61.6438% (minimum 75%, Uncertain); lymph node: 60.0000% (minimum 70%, Missing)",0.00217391,-0.1,-0.133562,0,0,routine_complete,2.8,3,2.4,"bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141384,TAF4B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.2308% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.6438% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 70%, Baseline (adaptation disabled))",0.00217391,-0.1,-0.133562,0,0,routine_complete,2.8,3,2.4,"bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141384,TAF4B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.1348% (minimum 99%, Missing); amygdala: 48.9552% (minimum 99%, Missing); basal ganglia: 20.9987% (minimum 99%, Missing); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 50.9317% (minimum 95%, Enhanced); choroid plexus: 76.6355% (minimum 99%, Missing); colon: 70.3863% (minimum 97%, Missing); duodenum: 91.6201% (minimum 99%, Missing); esophagus: 68.0498% (minimum 80%, Enhanced); heart muscle: 82.8283% (minimum 95%, Enhanced); hippocampal formation: 59.2058% (minimum 99%, Missing); hypothalamus: 57.1429% (minimum 99%, Missing); kidney: 80.7882% (minimum 99%, Missing); liver: 89.1304% (minimum 95%, Enhanced); lung: 86.3158% (minimum 99%, Missing); lymph node: 77.7251% (minimum 97%, Missing); midbrain: 63.5659% (minimum 99%, Missing); pancreas: 90.1099% (minimum 95%, Enhanced); parathyroid gland: 78.0952% (minimum 80%, Enhanced); pituitary gland: 50.9317% (minimum 99%, Missing); rectum: 82.4121% (minimum 97%, Missing); retina: 80.3922% (minimum 99%, Missing); salivary gland: 78.4689% (minimum 80%, Enhanced); skeletal muscle: 43.8503% (minimum 95%, Enhanced); small intestine: 84.1026% (minimum 99%, Missing); smooth muscle: 69.4915% (minimum 95%, Enhanced); spinal cord: 78.8462% (minimum 99%, Missing); spleen: 84.9741% (minimum 95%, Missing); thymus: 79.6117% (minimum 95%, Missing); tongue: 56.5517% (minimum 97%, Missing); urinary bladder: 56.1644% (minimum 97%, Missing)",-0.153883,-0.408356,-0.780013,0,11,partial,61.7,12.8,7.6,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 6); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 2); tongue: 12.6 nTPM (protected, limit 2); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); smooth muscle: 7.2 nTPM (vital, limit 6); colon: 6.9 nTPM (protected, limit 2); choroid plexus: 5 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); small intestine: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141404,GNAL,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 48.9552% (minimum 75%, Missing); basal ganglia: 20.9987% (minimum 75%, Missing); cerebral cortex: 50.9317% (minimum 60%, Enhanced); hippocampal formation: 59.2058% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); midbrain: 63.5659% (minimum 75%, Missing); pituitary gland: 50.9317% (minimum 75%, Missing); skeletal muscle: 43.8503% (minimum 60%, Enhanced); tongue: 56.5517% (minimum 70%, Missing); urinary bladder: 56.1644% (minimum 70%, Missing)",0.146117,-0.138356,-0.540013,0,11,partial,61.7,12.8,7.6,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 6); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 2); tongue: 12.6 nTPM (protected, limit 2); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); smooth muscle: 7.2 nTPM (vital, limit 6); colon: 6.9 nTPM (protected, limit 2); choroid plexus: 5 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); small intestine: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141404,GNAL,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 48.9552% (minimum 75%, Missing); basal ganglia: 20.9987% (minimum 75%, Missing); cerebral cortex: 50.9317% (minimum 60%, Enhanced); hippocampal formation: 59.2058% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); midbrain: 63.5659% (minimum 75%, Missing); pituitary gland: 50.9317% (minimum 75%, Missing); skeletal muscle: 43.8503% (minimum 60%, Enhanced); tongue: 56.5517% (minimum 70%, Missing); urinary bladder: 56.1644% (minimum 70%, Missing)",0.146117,-0.138356,-0.540013,0,11,partial,61.7,12.8,7.6,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 6); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 3); tongue: 12.6 nTPM (protected, limit 3); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); smooth muscle: 7.2 nTPM (vital, limit 6); colon: 6.9 nTPM (protected, limit 3); choroid plexus: 5 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 3); small intestine: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141404,GNAL,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 48.9552% (minimum 75%, Missing); basal ganglia: 20.9987% (minimum 75%, Missing); cerebral cortex: 50.9317% (minimum 60%, Enhanced); hippocampal formation: 59.2058% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); midbrain: 63.5659% (minimum 75%, Missing); pituitary gland: 50.9317% (minimum 75%, Missing); skeletal muscle: 43.8503% (minimum 60%, Enhanced); tongue: 56.5517% (minimum 70%, Missing); urinary bladder: 56.1644% (minimum 70%, Missing)",0.146117,-0.138356,-0.540013,0,11,partial,61.7,12.8,7.6,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 6); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 3); tongue: 12.6 nTPM (protected, limit 3); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); smooth muscle: 7.2 nTPM (vital, limit 6); colon: 6.9 nTPM (protected, limit 3); choroid plexus: 5 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 3); small intestine: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141404,GNAL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 48.9552% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 20.9987% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.9317% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.0498% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 59.2058% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 57.1429% (minimum 75%, Baseline (adaptation disabled)); midbrain: 63.5659% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 50.9317% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 43.8503% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 69.4915% (minimum 75%, Baseline (adaptation disabled)); tongue: 56.5517% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.1644% (minimum 70%, Baseline (adaptation disabled))",0.0333333,-0.138356,-0.540013,0,11,partial,61.7,12.8,7.6,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 3); tongue: 12.6 nTPM (protected, limit 3); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 3); thyroid gland: 7.6 nTPM (manageable, limit 5); adipose tissue: 7.4 nTPM (manageable, limit 5); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5); colon: 6.9 nTPM (protected, limit 3); choroid plexus: 5 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); parathyroid gland: 4.6 nTPM (protected, limit 3); salivary gland: 4.5 nTPM (protected, limit 3); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141404,GNAL,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.3210% (minimum 95%, Missing); adrenal gland: 76.9336% (minimum 99%, Missing); amygdala: 71.9590% (minimum 99%, Missing); basal ganglia: 75.8435% (minimum 99%, Missing); bone marrow: 90.9385% (minimum 99%, Missing); cerebellum: 73.8017% (minimum 99%, Missing); cerebral cortex: 70.9596% (minimum 99%, Missing); choroid plexus: 85.2807% (minimum 99%, Missing); colon: 79.7163% (minimum 97%, Missing); duodenum: 85.8671% (minimum 99%, Missing); esophagus: 83.1361% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 72.8451% (minimum 99%, Missing); hypothalamus: 73.9474% (minimum 99%, Missing); kidney: 81.3314% (minimum 99%, Missing); liver: 84.1948% (minimum 99%, Missing); lung: 85.7361% (minimum 99%, Missing); lymph node: 85.5403% (minimum 97%, Missing); midbrain: 73.9961% (minimum 99%, Missing); pancreas: 83.1976% (minimum 99%, Missing); parathyroid gland: 81.6860% (minimum 97%, Missing); pituitary gland: 80.5735% (minimum 99%, Missing); rectum: 84.9584% (minimum 97%, Missing); retina: 73.6566% (minimum 99%, Missing); salivary gland: 80.4006% (minimum 97%, Missing); skeletal muscle: 68.0387% (minimum 99%, Missing); skin: 84.7662% (minimum 95%, Missing); small intestine: 85.9327% (minimum 99%, Missing); smooth muscle: 84.5113% (minimum 99%, Missing); spinal cord: 72.4694% (minimum 99%, Missing); spleen: 83.8180% (minimum 95%, Missing); stomach: 84.4478% (minimum 97%, Missing); thymus: 85.2807% (minimum 95%, Missing); thyroid gland: 78.3275% (minimum 95%, Missing); tongue: 71.5468% (minimum 97%, Missing); urinary bladder: 80.8052% (minimum 97%, Missing)",-0.166725,-0.254532,-0.309613,0,12,partial,52.8,44.7,31.1,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 2); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 2); heart muscle: 28.1 nTPM (vital, limit 1); salivary gland: 27.4 nTPM (protected, limit 2); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 2); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 2); esophagus: 22.8 nTPM (protected, limit 2); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); spleen: 21.7 nTPM (manageable, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 2); smooth muscle: 20.6 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); rectum: 19.9 nTPM (protected, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); lymph node: 19 nTPM (protected, limit 2); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141425,RPRD1A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 71.9590% (minimum 75%, Missing); cerebellum: 73.8017% (minimum 75%, Missing); cerebral cortex: 70.9596% (minimum 75%, Missing); hippocampal formation: 72.8451% (minimum 75%, Missing); hypothalamus: 73.9474% (minimum 75%, Missing); midbrain: 73.9961% (minimum 75%, Missing); retina: 73.6566% (minimum 75%, Missing); skeletal muscle: 68.0387% (minimum 75%, Missing); spinal cord: 72.4694% (minimum 75%, Missing)",0.133275,0.0154679,-0.0696126,0,12,partial,52.8,44.7,31.1,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 2); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 2); heart muscle: 28.1 nTPM (vital, limit 1); salivary gland: 27.4 nTPM (protected, limit 2); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 2); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 2); esophagus: 22.8 nTPM (protected, limit 2); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); spleen: 21.7 nTPM (manageable, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 2); smooth muscle: 20.6 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); rectum: 19.9 nTPM (protected, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); lymph node: 19 nTPM (protected, limit 2); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141425,RPRD1A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 71.9590% (minimum 75%, Missing); cerebellum: 73.8017% (minimum 75%, Missing); cerebral cortex: 70.9596% (minimum 75%, Missing); hippocampal formation: 72.8451% (minimum 75%, Missing); hypothalamus: 73.9474% (minimum 75%, Missing); midbrain: 73.9961% (minimum 75%, Missing); retina: 73.6566% (minimum 75%, Missing); skeletal muscle: 68.0387% (minimum 75%, Missing); spinal cord: 72.4694% (minimum 75%, Missing)",0.133275,0.0154679,-0.0696126,0,12,partial,52.8,44.7,31.1,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 3); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 3); heart muscle: 28.1 nTPM (vital, limit 1); salivary gland: 27.4 nTPM (protected, limit 3); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 3); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 3); esophagus: 22.8 nTPM (protected, limit 3); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); spleen: 21.7 nTPM (manageable, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 3); smooth muscle: 20.6 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); rectum: 19.9 nTPM (protected, limit 3); choroid plexus: 19.4 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); lymph node: 19 nTPM (protected, limit 3); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141425,RPRD1A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 71.9590% (minimum 75%, Missing); cerebellum: 73.8017% (minimum 75%, Missing); cerebral cortex: 70.9596% (minimum 75%, Missing); hippocampal formation: 72.8451% (minimum 75%, Missing); hypothalamus: 73.9474% (minimum 75%, Missing); midbrain: 73.9961% (minimum 75%, Missing); retina: 73.6566% (minimum 75%, Missing); skeletal muscle: 68.0387% (minimum 75%, Missing); spinal cord: 72.4694% (minimum 75%, Missing)",0.133275,0.0154679,-0.0696126,0,12,partial,52.8,44.7,31.1,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 3); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 3); heart muscle: 28.1 nTPM (vital, limit 1); salivary gland: 27.4 nTPM (protected, limit 3); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 3); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 3); esophagus: 22.8 nTPM (protected, limit 3); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); spleen: 21.7 nTPM (manageable, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 3); smooth muscle: 20.6 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); rectum: 19.9 nTPM (protected, limit 3); choroid plexus: 19.4 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); lymph node: 19 nTPM (protected, limit 3); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141425,RPRD1A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 71.9590% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.8017% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.9596% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.8451% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.9474% (minimum 75%, Baseline (adaptation disabled)); midbrain: 73.9961% (minimum 75%, Baseline (adaptation disabled)); retina: 73.6566% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 68.0387% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.4694% (minimum 75%, Baseline (adaptation disabled))",0.133275,0.0154679,-0.0696126,0,12,partial,52.8,44.7,31.1,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 3); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 3); heart muscle: 28.1 nTPM (vital, limit 1); salivary gland: 27.4 nTPM (protected, limit 3); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 3); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 3); esophagus: 22.8 nTPM (protected, limit 3); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); spleen: 21.7 nTPM (manageable, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 3); smooth muscle: 20.6 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); rectum: 19.9 nTPM (protected, limit 3); choroid plexus: 19.4 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); lymph node: 19 nTPM (protected, limit 3); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141425,RPRD1A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.4737% (minimum 95%, Missing); amygdala: 68.0000% (minimum 99%, Missing); basal ganglia: 80.9524% (minimum 99%, Missing); cerebellum: 94.4444% (minimum 99%, Missing); cerebral cortex: 53.1250% (minimum 99%, Missing); choroid plexus: 77.2727% (minimum 99%, Missing); colon: 73.9130% (minimum 97%, Missing); duodenum: 89.4737% (minimum 99%, Missing); heart muscle: 77.2727% (minimum 99%, Missing); hippocampal formation: 70.8333% (minimum 99%, Missing); hypothalamus: 65.3846% (minimum 99%, Missing); kidney: 73.9130% (minimum 99%, Missing); liver: 80.9524% (minimum 99%, Missing); lung: 89.4737% (minimum 99%, Missing); midbrain: 73.9130% (minimum 99%, Missing); pancreas: 85.0000% (minimum 99%, Missing); parathyroid gland: 89.4737% (minimum 97%, Missing); pituitary gland: 70.8333% (minimum 99%, Missing); rectum: 94.4444% (minimum 97%, Missing); retina: 77.2727% (minimum 99%, Missing); salivary gland: 89.4737% (minimum 97%, Missing); skin: 94.4444% (minimum 95%, Missing); small intestine: 85.0000% (minimum 99%, Missing); smooth muscle: 89.4737% (minimum 99%, Missing); spinal cord: 73.9130% (minimum 99%, Missing); spleen: 94.4444% (minimum 95%, Missing); stomach: 68.0000% (minimum 97%, Missing); thyroid gland: 65.3846% (minimum 95%, Missing); urinary bladder: 77.2727% (minimum 97%, Missing)",-0.296154,-0.29,-0.45875,0,80,unavailable,1.5,0.8,0.9,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141431,ASXL3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 68.0000% (minimum 75%, Missing); cerebral cortex: 53.1250% (minimum 75%, Missing); hippocampal formation: 70.8333% (minimum 75%, Missing); hypothalamus: 65.3846% (minimum 75%, Missing); kidney: 73.9130% (minimum 75%, Missing); midbrain: 73.9130% (minimum 75%, Missing); pituitary gland: 70.8333% (minimum 75%, Missing); spinal cord: 73.9130% (minimum 75%, Missing); stomach: 68.0000% (minimum 70%, Missing)",0.00384615,-0.02,-0.21875,0,80,unavailable,1.5,0.8,0.9,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141431,ASXL3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 68.0000% (minimum 75%, Missing); cerebral cortex: 53.1250% (minimum 75%, Missing); hippocampal formation: 70.8333% (minimum 75%, Missing); hypothalamus: 65.3846% (minimum 75%, Missing); kidney: 73.9130% (minimum 75%, Missing); midbrain: 73.9130% (minimum 75%, Missing); pituitary gland: 70.8333% (minimum 75%, Missing); spinal cord: 73.9130% (minimum 75%, Missing); stomach: 68.0000% (minimum 70%, Missing)",0.00384615,-0.02,-0.21875,0,80,unavailable,1.5,0.8,0.9,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141431,ASXL3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 68.0000% (minimum 75%, Missing); cerebral cortex: 53.1250% (minimum 75%, Missing); hippocampal formation: 70.8333% (minimum 75%, Missing); hypothalamus: 65.3846% (minimum 75%, Missing); kidney: 73.9130% (minimum 75%, Missing); midbrain: 73.9130% (minimum 75%, Missing); pituitary gland: 70.8333% (minimum 75%, Missing); spinal cord: 73.9130% (minimum 75%, Missing); stomach: 68.0000% (minimum 70%, Missing)",0.00384615,-0.02,-0.21875,0,80,unavailable,1.5,0.8,0.9,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141431,ASXL3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 68.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.1250% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.8333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.3846% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.9130% (minimum 75%, Baseline (adaptation disabled)); midbrain: 73.9130% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 70.8333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.9130% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.0000% (minimum 70%, Baseline (adaptation disabled))",0.00384615,-0.02,-0.21875,0,80,unavailable,1.5,0.8,0.9,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141431,ASXL3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 94.3925% (minimum 99%, Missing); pituitary gland: 98.0583% (minimum 99%, Missing); skeletal muscle: 95.2830% (minimum 99%, Missing)",0.0305825,0.03,-0.0460748,0,80,unavailable,0.6,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141437,SLC25A52,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.330583,0.3,0.193925,0,80,unavailable,0.6,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141437,SLC25A52,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.330583,0.3,0.193925,0,80,unavailable,0.6,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141437,SLC25A52,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.330583,0.3,0.193925,0,80,unavailable,0.6,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141437,SLC25A52,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.330583,0.3,0.193925,0,80,unavailable,0.6,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141437,SLC25A52,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.1781% (minimum 95%, Missing); adrenal gland: 95.4861% (minimum 99%, Missing); amygdala: 93.8567% (minimum 99%, Missing); basal ganglia: 96.1538% (minimum 99%, Missing); bone marrow: 96.4912% (minimum 99%, Missing); cerebellum: 98.5663% (minimum 99%, Missing); cerebral cortex: 95.4861% (minimum 99%, Missing); choroid plexus: 92.2819% (minimum 99%, Missing); duodenum: 87.5796% (minimum 99%, Missing); esophagus: 96.8310% (minimum 97%, Missing); heart muscle: 98.2143% (minimum 99%, Missing); hippocampal formation: 93.8567% (minimum 99%, Missing); hypothalamus: 95.1557% (minimum 99%, Missing); kidney: 93.5374% (minimum 99%, Missing); liver: 90.1639% (minimum 99%, Missing); lung: 85.9375% (minimum 99%, Missing); lymph node: 94.5017% (minimum 97%, Missing); midbrain: 93.5374% (minimum 99%, Missing); pancreas: 95.8188% (minimum 99%, Missing); parathyroid gland: 83.8415% (minimum 97%, Missing); pituitary gland: 95.4861% (minimum 99%, Missing); retina: 98.9209% (minimum 99%, Missing); salivary gland: 90.1639% (minimum 97%, Missing); skeletal muscle: 98.5663% (minimum 99%, Missing); small intestine: 90.4605% (minimum 99%, Missing); smooth muscle: 97.8648% (minimum 99%, Missing); spinal cord: 89.5765% (minimum 99%, Missing); spleen: 83.8415% (minimum 95%, Missing); stomach: 93.8567% (minimum 97%, Missing); urinary bladder: 94.1781% (minimum 97%, Missing)",-0.111585,-0.131585,-0.130625,0,80,unavailable,4.5,5.3,5.3,"spleen: 5.3 nTPM (manageable, limit 5); parathyroid gland: 5.3 nTPM (protected, limit 2); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141497,ZMYND15,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.188415,0.138415,0.109375,0,80,unavailable,4.5,5.3,5.3,"spleen: 5.3 nTPM (manageable, limit 5); parathyroid gland: 5.3 nTPM (protected, limit 2); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141497,ZMYND15,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.188415,0.138415,0.109375,0,80,unavailable,4.5,5.3,5.3,"spleen: 5.3 nTPM (manageable, limit 5); parathyroid gland: 5.3 nTPM (protected, limit 3); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141497,ZMYND15,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.188415,0.138415,0.109375,0,80,unavailable,4.5,5.3,5.3,"spleen: 5.3 nTPM (manageable, limit 5); parathyroid gland: 5.3 nTPM (protected, limit 3); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141497,ZMYND15,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.188415,0.138415,0.109375,0,80,unavailable,4.5,5.3,5.3,"spleen: 5.3 nTPM (manageable, limit 5); parathyroid gland: 5.3 nTPM (protected, limit 3); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141497,ZMYND15,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.8339% (minimum 95%, Enhanced); amygdala: 79.3210% (minimum 99%, Missing); basal ganglia: 83.9869% (minimum 99%, Missing); bone marrow: 91.4591% (minimum 95%, Enhanced); cerebellum: 54.7974% (minimum 95%, Enhanced); cerebral cortex: 63.7717% (minimum 95%, Enhanced); choroid plexus: 85.3821% (minimum 99%, Missing); duodenum: 92.1147% (minimum 95%, Enhanced); hippocampal formation: 82.9032% (minimum 99%, Missing); hypothalamus: 78.5933% (minimum 99%, Missing); liver: 2.3550% (minimum 99%, Missing); lung: 87.1186% (minimum 95%, Enhanced); midbrain: 86.8243% (minimum 99%, Missing); parathyroid gland: 79.0769% (minimum 80%, Enhanced); pituitary gland: 90.1754% (minimum 99%, Missing); retina: 84.8185% (minimum 99%, Missing); skeletal muscle: 94.8339% (minimum 95%, Enhanced); skin: 85.6667% (minimum 95%, Missing); small intestine: 94.8339% (minimum 95%, Enhanced); spinal cord: 91.1348% (minimum 99%, Missing); stomach: 95.1852% (minimum 97%, Missing)",-0.0933333,-0.0181481,-0.96645,0,5,partial,1065.6,6.8,5.6,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 6); cerebral cortex: 14.6 nTPM (vital, limit 6); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1)",liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141505,ASGR1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 54.7974% (minimum 60%, Enhanced); liver: 2.3550% (minimum 75%, Missing)",0.206667,0.240769,-0.72645,0,5,partial,1065.6,6.8,5.6,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 6); cerebral cortex: 14.6 nTPM (vital, limit 6); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1)",liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141505,ASGR1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 54.7974% (minimum 60%, Enhanced); liver: 2.3550% (minimum 75%, Missing)",0.206667,0.240769,-0.72645,0,5,partial,1065.6,6.8,5.6,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 6); cerebral cortex: 14.6 nTPM (vital, limit 6); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1)",liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141505,ASGR1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 54.7974% (minimum 60%, Enhanced); liver: 2.3550% (minimum 75%, Missing)",0.206667,0.240769,-0.72645,0,5,partial,1065.6,6.8,5.6,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 6); cerebral cortex: 14.6 nTPM (vital, limit 6); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1)",liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141505,ASGR1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 54.7974% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.7717% (minimum 75%, Baseline (adaptation disabled)); liver: 2.3550% (minimum 75%, Baseline (adaptation disabled))",0.171086,0.0907692,-0.72645,0,5,partial,1065.6,6.8,5.6,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); parathyroid gland: 6.8 nTPM (protected, limit 3); amygdala: 6.7 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141505,ASGR1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.9541% (minimum 95%, Missing); adrenal gland: 90.5045% (minimum 99%, Missing); amygdala: 39.7653% (minimum 99%, Missing); basal ganglia: 42.1271% (minimum 99%, Missing); bone marrow: 93.5583% (minimum 99%, Missing); cerebellum: 56.1694% (minimum 99%, Missing); cerebral cortex: 28.9100% (minimum 99%, Missing); choroid plexus: 75.6824% (minimum 99%, Missing); colon: 76.2500% (minimum 97%, Missing); duodenum: 76.6332% (minimum 99%, Missing); heart muscle: 83.1063% (minimum 99%, Missing); hippocampal formation: 33.5903% (minimum 99%, Missing); hypothalamus: 47.2136% (minimum 99%, Missing); kidney: 84.4875% (minimum 99%, Missing); liver: 92.7052% (minimum 99%, Missing); lung: 95.6113% (minimum 99%, Missing); lymph node: 85.9155% (minimum 97%, Missing); midbrain: 42.7171% (minimum 99%, Missing); pancreas: 90.2367% (minimum 99%, Missing); parathyroid gland: 68.3857% (minimum 97%, Missing); pituitary gland: 83.3333% (minimum 99%, Missing); rectum: 81.9892% (minimum 97%, Missing); retina: 34.7777% (minimum 99%, Missing); salivary gland: 94.1358% (minimum 97%, Missing); skeletal muscle: 29.9902% (minimum 99%, Missing); small intestine: 75.1232% (minimum 99%, Missing); smooth muscle: 94.4272% (minimum 99%, Missing); spinal cord: 53.1359% (minimum 99%, Missing); spleen: 89.9705% (minimum 95%, Missing); stomach: 89.1813% (minimum 97%, Missing); thymus: 91.8675% (minimum 95%, Missing); thyroid gland: 90.2367% (minimum 95%, Missing); tongue: 42.0690% (minimum 97%, Missing); urinary bladder: 91.3174% (minimum 97%, Missing)",-0.250459,-0.54931,-0.7009,0,80,unavailable,75,42,13.1,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 2); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); adipose tissue: 13.1 nTPM (manageable, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141576,RNF157,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 39.7653% (minimum 75%, Missing); basal ganglia: 42.1271% (minimum 75%, Missing); cerebellum: 56.1694% (minimum 75%, Missing); cerebral cortex: 28.9100% (minimum 75%, Missing); hippocampal formation: 33.5903% (minimum 75%, Missing); hypothalamus: 47.2136% (minimum 75%, Missing); midbrain: 42.7171% (minimum 75%, Missing); parathyroid gland: 68.3857% (minimum 70%, Missing); retina: 34.7777% (minimum 75%, Missing); skeletal muscle: 29.9902% (minimum 75%, Missing); spinal cord: 53.1359% (minimum 75%, Missing); tongue: 42.0690% (minimum 70%, Missing)",0.0495413,-0.27931,-0.4609,0,80,unavailable,75,42,13.1,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 2); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); adipose tissue: 13.1 nTPM (manageable, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141576,RNF157,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 39.7653% (minimum 75%, Missing); basal ganglia: 42.1271% (minimum 75%, Missing); cerebellum: 56.1694% (minimum 75%, Missing); cerebral cortex: 28.9100% (minimum 75%, Missing); hippocampal formation: 33.5903% (minimum 75%, Missing); hypothalamus: 47.2136% (minimum 75%, Missing); midbrain: 42.7171% (minimum 75%, Missing); parathyroid gland: 68.3857% (minimum 70%, Missing); retina: 34.7777% (minimum 75%, Missing); skeletal muscle: 29.9902% (minimum 75%, Missing); spinal cord: 53.1359% (minimum 75%, Missing); tongue: 42.0690% (minimum 70%, Missing)",0.0495413,-0.27931,-0.4609,0,80,unavailable,75,42,13.1,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 3); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); adipose tissue: 13.1 nTPM (manageable, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 3); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141576,RNF157,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 39.7653% (minimum 75%, Missing); basal ganglia: 42.1271% (minimum 75%, Missing); cerebellum: 56.1694% (minimum 75%, Missing); cerebral cortex: 28.9100% (minimum 75%, Missing); hippocampal formation: 33.5903% (minimum 75%, Missing); hypothalamus: 47.2136% (minimum 75%, Missing); midbrain: 42.7171% (minimum 75%, Missing); parathyroid gland: 68.3857% (minimum 70%, Missing); retina: 34.7777% (minimum 75%, Missing); skeletal muscle: 29.9902% (minimum 75%, Missing); spinal cord: 53.1359% (minimum 75%, Missing); tongue: 42.0690% (minimum 70%, Missing)",0.0495413,-0.27931,-0.4609,0,80,unavailable,75,42,13.1,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 3); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); adipose tissue: 13.1 nTPM (manageable, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 3); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141576,RNF157,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 39.7653% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 42.1271% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.1694% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 28.9100% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 33.5903% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 47.2136% (minimum 75%, Baseline (adaptation disabled)); midbrain: 42.7171% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 68.3857% (minimum 70%, Baseline (adaptation disabled)); retina: 34.7777% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 29.9902% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.1359% (minimum 75%, Baseline (adaptation disabled)); tongue: 42.0690% (minimum 70%, Baseline (adaptation disabled))",0.0495413,-0.27931,-0.4609,0,80,unavailable,75,42,13.1,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 3); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); adipose tissue: 13.1 nTPM (manageable, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 3); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141576,RNF157,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.6184% (minimum 90%, Approved); adrenal gland: 68.9766% (minimum 99%, Missing); amygdala: 78.1735% (minimum 99%, Missing); basal ganglia: 76.6338% (minimum 99%, Missing); bone marrow: 66.1004% (minimum 99%, Missing); cerebellum: 70.2215% (minimum 99%, Missing); cerebral cortex: 71.3928% (minimum 99%, Missing); choroid plexus: 80.1498% (minimum 99%, Missing); colon: 71.2739% (minimum 97%, Missing); duodenum: 78.1022% (minimum 99%, Missing); esophagus: 69.1997% (minimum 97%, Missing); heart muscle: 71.2739% (minimum 99%, Missing); hippocampal formation: 77.2563% (minimum 99%, Missing); hypothalamus: 78.9668% (minimum 99%, Missing); kidney: 73.0375% (minimum 99%, Missing); liver: 71.0963% (minimum 98%, Approved); lung: 74.6946% (minimum 99%, Missing); lymph node: 74.1126% (minimum 97%, Missing); midbrain: 80.2249% (minimum 99%, Missing); pancreas: 71.8724% (minimum 99%, Missing); parathyroid gland: 73.0999% (minimum 97%, Missing); pituitary gland: 67.2956% (minimum 99%, Missing); rectum: 83.1068% (minimum 97%, Missing); retina: 78.5321% (minimum 99%, Missing); salivary gland: 74.3056% (minimum 97%, Missing); skeletal muscle: 63.5015% (minimum 99%, Missing); skin: 67.0321% (minimum 95%, Missing); small intestine: 72.3584% (minimum 99%, Missing); smooth muscle: 80.8310% (minimum 98%, Approved); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 68.1529% (minimum 95%, Missing); stomach: 72.4196% (minimum 97%, Missing); thymus: 74.5645% (minimum 95%, Missing); thyroid gland: 71.3928% (minimum 95%, Missing); tongue: 75.3521% (minimum 97%, Missing); urinary bladder: 71.4524% (minimum 97%, Missing)",-0.279679,-0.278003,-0.354985,0,5,partial,49.2,38.1,42.1,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); skin: 42.1 nTPM (manageable, limit 5); pituitary gland: 41.6 nTPM (vital, limit 1); spleen: 40 nTPM (manageable, limit 5); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 2); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 2); colon: 34.5 nTPM (protected, limit 2); heart muscle: 34.5 nTPM (vital, limit 1); cerebral cortex: 34.3 nTPM (vital, limit 1); thyroid gland: 34.3 nTPM (manageable, limit 5); urinary bladder: 34.2 nTPM (protected, limit 2); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 2); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 2); lymph node: 29.9 nTPM (protected, limit 2); salivary gland: 29.6 nTPM (protected, limit 2); thymus: 29.2 nTPM (manageable, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 2); adipose tissue: 27.6 nTPM (manageable, limit 10); basal ganglia: 26.1 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 2); rectum: 17.4 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141644,MBD1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.9766% (minimum 75%, Missing); bone marrow: 66.1004% (minimum 75%, Missing); cerebellum: 70.2215% (minimum 75%, Missing); cerebral cortex: 71.3928% (minimum 75%, Missing); esophagus: 69.1997% (minimum 70%, Missing); heart muscle: 71.2739% (minimum 75%, Missing); kidney: 73.0375% (minimum 75%, Missing); lung: 74.6946% (minimum 75%, Missing); pancreas: 71.8724% (minimum 75%, Missing); pituitary gland: 67.2956% (minimum 75%, Missing); skeletal muscle: 63.5015% (minimum 75%, Missing); small intestine: 72.3584% (minimum 75%, Missing)",0.0203211,-0.00800323,-0.114985,0,5,partial,49.2,38.1,42.1,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); skin: 42.1 nTPM (manageable, limit 5); pituitary gland: 41.6 nTPM (vital, limit 1); spleen: 40 nTPM (manageable, limit 5); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 2); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 2); colon: 34.5 nTPM (protected, limit 2); heart muscle: 34.5 nTPM (vital, limit 1); cerebral cortex: 34.3 nTPM (vital, limit 1); thyroid gland: 34.3 nTPM (manageable, limit 5); urinary bladder: 34.2 nTPM (protected, limit 2); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 2); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 2); lymph node: 29.9 nTPM (protected, limit 2); salivary gland: 29.6 nTPM (protected, limit 2); thymus: 29.2 nTPM (manageable, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 2); adipose tissue: 27.6 nTPM (manageable, limit 10); basal ganglia: 26.1 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 2); rectum: 17.4 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141644,MBD1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.9766% (minimum 75%, Missing); bone marrow: 66.1004% (minimum 75%, Missing); cerebellum: 70.2215% (minimum 75%, Missing); cerebral cortex: 71.3928% (minimum 75%, Missing); esophagus: 69.1997% (minimum 70%, Missing); heart muscle: 71.2739% (minimum 75%, Missing); kidney: 73.0375% (minimum 75%, Missing); lung: 74.6946% (minimum 75%, Missing); pancreas: 71.8724% (minimum 75%, Missing); pituitary gland: 67.2956% (minimum 75%, Missing); skeletal muscle: 63.5015% (minimum 75%, Missing); small intestine: 72.3584% (minimum 75%, Missing)",0.0203211,-0.00800323,-0.114985,0,5,partial,49.2,38.1,42.1,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); skin: 42.1 nTPM (manageable, limit 5); pituitary gland: 41.6 nTPM (vital, limit 1); spleen: 40 nTPM (manageable, limit 5); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 3); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 2); colon: 34.5 nTPM (protected, limit 3); heart muscle: 34.5 nTPM (vital, limit 1); cerebral cortex: 34.3 nTPM (vital, limit 1); thyroid gland: 34.3 nTPM (manageable, limit 5); urinary bladder: 34.2 nTPM (protected, limit 3); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 3); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 3); lymph node: 29.9 nTPM (protected, limit 3); salivary gland: 29.6 nTPM (protected, limit 3); thymus: 29.2 nTPM (manageable, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 3); adipose tissue: 27.6 nTPM (manageable, limit 10); basal ganglia: 26.1 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 2); rectum: 17.4 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141644,MBD1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.9766% (minimum 75%, Missing); bone marrow: 66.1004% (minimum 75%, Missing); cerebellum: 70.2215% (minimum 75%, Missing); cerebral cortex: 71.3928% (minimum 75%, Missing); esophagus: 69.1997% (minimum 70%, Missing); heart muscle: 71.2739% (minimum 75%, Missing); kidney: 73.0375% (minimum 75%, Missing); lung: 74.6946% (minimum 75%, Missing); pancreas: 71.8724% (minimum 75%, Missing); pituitary gland: 67.2956% (minimum 75%, Missing); skeletal muscle: 63.5015% (minimum 75%, Missing); small intestine: 72.3584% (minimum 75%, Missing)",0.0203211,-0.00800323,-0.114985,0,5,partial,49.2,38.1,42.1,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); skin: 42.1 nTPM (manageable, limit 5); pituitary gland: 41.6 nTPM (vital, limit 1); spleen: 40 nTPM (manageable, limit 5); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 3); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 2); colon: 34.5 nTPM (protected, limit 3); heart muscle: 34.5 nTPM (vital, limit 1); cerebral cortex: 34.3 nTPM (vital, limit 1); thyroid gland: 34.3 nTPM (manageable, limit 5); urinary bladder: 34.2 nTPM (protected, limit 3); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 3); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 3); lymph node: 29.9 nTPM (protected, limit 3); salivary gland: 29.6 nTPM (protected, limit 3); thymus: 29.2 nTPM (manageable, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 3); adipose tissue: 27.6 nTPM (manageable, limit 10); basal ganglia: 26.1 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 2); rectum: 17.4 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141644,MBD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.9766% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.1004% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.2215% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 71.3928% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.1997% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 71.2739% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.0375% (minimum 75%, Baseline (adaptation disabled)); liver: 71.0963% (minimum 75%, Baseline (adaptation disabled)); lung: 74.6946% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.8724% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 67.2956% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 63.5015% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.3584% (minimum 75%, Baseline (adaptation disabled))",0.0203211,-0.00800323,-0.114985,0,5,partial,49.2,38.1,42.1,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); skin: 42.1 nTPM (manageable, limit 5); pituitary gland: 41.6 nTPM (vital, limit 1); spleen: 40 nTPM (manageable, limit 5); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 3); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 1); colon: 34.5 nTPM (protected, limit 3); heart muscle: 34.5 nTPM (vital, limit 1); cerebral cortex: 34.3 nTPM (vital, limit 1); thyroid gland: 34.3 nTPM (manageable, limit 5); urinary bladder: 34.2 nTPM (protected, limit 3); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 3); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 3); lymph node: 29.9 nTPM (protected, limit 3); salivary gland: 29.6 nTPM (protected, limit 3); thymus: 29.2 nTPM (manageable, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 3); adipose tissue: 27.6 nTPM (manageable, limit 5); basal ganglia: 26.1 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141644,MBD1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.0000% (minimum 99%, Missing); amygdala: 87.3418% (minimum 99%, Missing); basal ganglia: 83.1325% (minimum 99%, Missing); bone marrow: 98.5714% (minimum 99%, Missing); cerebellum: 93.2432% (minimum 99%, Missing); cerebral cortex: 84.1463% (minimum 99%, Missing); choroid plexus: 70.4082% (minimum 99%, Missing); duodenum: 98.5714% (minimum 99%, Missing); heart muscle: 98.5714% (minimum 99%, Missing); hippocampal formation: 86.2500% (minimum 99%, Missing); hypothalamus: 85.1852% (minimum 99%, Missing); kidney: 87.3418% (minimum 99%, Missing); liver: 94.5205% (minimum 99%, Missing); lung: 94.5205% (minimum 99%, Missing); midbrain: 88.4615% (minimum 99%, Missing); pancreas: 94.5205% (minimum 99%, Missing); parathyroid gland: 92.0000% (minimum 97%, Missing); pituitary gland: 83.1325% (minimum 99%, Missing); retina: 67.6471% (minimum 99%, Missing); salivary gland: 95.8333% (minimum 97%, Missing); skeletal muscle: 98.5714% (minimum 99%, Missing); small intestine: 98.5714% (minimum 99%, Missing); spinal cord: 88.4615% (minimum 99%, Missing); thyroid gland: 92.0000% (minimum 95%, Missing)",-0.03,-0.05,-0.313529,0,80,unavailable,3.3,0.6,0.6,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141665,FBXO15,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 70.4082% (minimum 75%, Missing); retina: 67.6471% (minimum 75%, Missing)",0.27,0.22,-0.0735294,0,80,unavailable,3.3,0.6,0.6,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141665,FBXO15,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 70.4082% (minimum 75%, Missing); retina: 67.6471% (minimum 75%, Missing)",0.27,0.22,-0.0735294,0,80,unavailable,3.3,0.6,0.6,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141665,FBXO15,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 70.4082% (minimum 75%, Missing); retina: 67.6471% (minimum 75%, Missing)",0.27,0.22,-0.0735294,0,80,unavailable,3.3,0.6,0.6,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141665,FBXO15,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 70.4082% (minimum 75%, Baseline (adaptation disabled)); retina: 67.6471% (minimum 75%, Baseline (adaptation disabled))",0.27,0.22,-0.0735294,0,80,unavailable,3.3,0.6,0.6,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141665,FBXO15,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 75.0000% (minimum 99%, Missing); skeletal muscle: 60.0000% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); spleen: 75.0000% (minimum 95%, Missing)",-0.2,0.03,-0.39,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141946,ZIM3,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 75.0000% (minimum 75%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing)",0.1,0.3,-0.15,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141946,ZIM3,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 75.0000% (minimum 75%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing)",0.1,0.3,-0.15,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141946,ZIM3,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 75.0000% (minimum 75%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing)",0.1,0.3,-0.15,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141946,ZIM3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 75.0000% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled))",0.1,0.3,-0.15,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141946,ZIM3,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.8421% (minimum 99%, Missing); lymph node: 87.5000% (minimum 97%, Missing); spleen: 87.5000% (minimum 95%, Missing)",-0.075,-0.095,-0.621579,0,80,unavailable,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141977,CIB3,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.8421% (minimum 75%, Missing)",0.225,0.175,-0.381579,0,80,unavailable,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141977,CIB3,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.8421% (minimum 75%, Missing)",0.225,0.175,-0.381579,0,80,unavailable,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141977,CIB3,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.8421% (minimum 75%, Missing)",0.225,0.175,-0.381579,0,80,unavailable,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141977,CIB3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.8421% (minimum 75%, Baseline (adaptation disabled))",0.225,0.175,-0.381579,0,80,unavailable,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000141977,CIB3,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0474874,0.0249875,0.0025,0,3,partial,0.3,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142025,DMRTC2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347487,0.294987,0.2425,0,3,partial,0.3,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142025,DMRTC2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347487,0.294987,0.2425,0,3,partial,0.3,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142025,DMRTC2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347487,0.294987,0.2425,0,3,partial,0.3,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142025,DMRTC2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347487,0.294987,0.2425,0,3,partial,0.3,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142025,DMRTC2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.5385% (minimum 95%, Missing); adrenal gland: 81.8182% (minimum 99%, Missing); amygdala: 81.8182% (minimum 99%, Missing); basal ganglia: 78.9474% (minimum 99%, Missing); bone marrow: 95.7447% (minimum 99%, Missing); cerebellum: 78.9474% (minimum 99%, Missing); cerebral cortex: 61.6438% (minimum 99%, Missing); choroid plexus: 95.7447% (minimum 99%, Missing); colon: 56.2500% (minimum 97%, Missing); duodenum: 76.2712% (minimum 99%, Missing); esophagus: 91.8367% (minimum 97%, Missing); heart muscle: 91.8367% (minimum 99%, Missing); hippocampal formation: 76.2712% (minimum 99%, Missing); hypothalamus: 78.9474% (minimum 99%, Missing); kidney: 55.5556% (minimum 99%, Missing); liver: 90.0000% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 93.7500% (minimum 97%, Missing); midbrain: 93.7500% (minimum 99%, Missing); pancreas: 32.1429% (minimum 99%, Missing); pituitary gland: 80.3571% (minimum 99%, Missing); rectum: 55.5556% (minimum 97%, Missing); retina: 60.8108% (minimum 99%, Missing); salivary gland: 90.0000% (minimum 97%, Missing); skeletal muscle: 93.7500% (minimum 99%, Missing); skin: 60.8108% (minimum 95%, Missing); small intestine: 63.3803% (minimum 99%, Missing); smooth muscle: 66.1765% (minimum 99%, Missing); spinal cord: 93.7500% (minimum 99%, Missing); stomach: 78.9474% (minimum 97%, Missing); thymus: 86.5385% (minimum 95%, Missing); thyroid gland: 90.0000% (minimum 95%, Missing); tongue: 95.7447% (minimum 97%, Missing); urinary bladder: 76.2712% (minimum 97%, Missing)",-0.341892,-0.414444,-0.668571,0,2,partial,9.5,3.6,2.9,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142149,HUNK,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 61.6438% (minimum 75%, Missing); colon: 56.2500% (minimum 70%, Missing); kidney: 55.5556% (minimum 75%, Missing); pancreas: 32.1429% (minimum 75%, Missing); rectum: 55.5556% (minimum 70%, Missing); retina: 60.8108% (minimum 75%, Missing); skin: 60.8108% (minimum 65%, Missing); small intestine: 63.3803% (minimum 75%, Missing); smooth muscle: 66.1765% (minimum 75%, Missing)",-0.0418919,-0.144444,-0.428571,0,2,partial,9.5,3.6,2.9,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142149,HUNK,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 61.6438% (minimum 75%, Missing); colon: 56.2500% (minimum 70%, Missing); kidney: 55.5556% (minimum 75%, Missing); pancreas: 32.1429% (minimum 75%, Missing); rectum: 55.5556% (minimum 70%, Missing); retina: 60.8108% (minimum 75%, Missing); skin: 60.8108% (minimum 65%, Missing); small intestine: 63.3803% (minimum 75%, Missing); smooth muscle: 66.1765% (minimum 75%, Missing)",-0.0418919,-0.144444,-0.428571,0,2,partial,9.5,3.6,2.9,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142149,HUNK,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 61.6438% (minimum 75%, Missing); colon: 56.2500% (minimum 70%, Missing); kidney: 55.5556% (minimum 75%, Missing); pancreas: 32.1429% (minimum 75%, Missing); rectum: 55.5556% (minimum 70%, Missing); retina: 60.8108% (minimum 75%, Missing); skin: 60.8108% (minimum 65%, Missing); small intestine: 63.3803% (minimum 75%, Missing); smooth muscle: 66.1765% (minimum 75%, Missing)",-0.0418919,-0.144444,-0.428571,0,2,partial,9.5,3.6,2.9,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142149,HUNK,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 61.6438% (minimum 75%, Baseline (adaptation disabled)); colon: 56.2500% (minimum 70%, Baseline (adaptation disabled)); kidney: 55.5556% (minimum 75%, Baseline (adaptation disabled)); pancreas: 32.1429% (minimum 75%, Baseline (adaptation disabled)); rectum: 55.5556% (minimum 70%, Baseline (adaptation disabled)); retina: 60.8108% (minimum 75%, Baseline (adaptation disabled)); skin: 60.8108% (minimum 65%, Baseline (adaptation disabled)); small intestine: 63.3803% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.1765% (minimum 75%, Baseline (adaptation disabled))",-0.0418919,-0.144444,-0.428571,0,2,partial,9.5,3.6,2.9,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142149,HUNK,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 2.9361% (minimum 97%, Missing)",0.05,-0.940639,0.01,0,80,unavailable,0,56.2,0,"parathyroid gland: 56.2 nTPM (protected, limit 2)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142511,GPR32,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 2.9361% (minimum 70%, Missing)",0.35,-0.670639,0.25,0,80,unavailable,0,56.2,0,"parathyroid gland: 56.2 nTPM (protected, limit 2)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142511,GPR32,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 2.9361% (minimum 70%, Missing)",0.35,-0.670639,0.25,0,80,unavailable,0,56.2,0,"parathyroid gland: 56.2 nTPM (protected, limit 3)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142511,GPR32,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 2.9361% (minimum 70%, Missing)",0.35,-0.670639,0.25,0,80,unavailable,0,56.2,0,"parathyroid gland: 56.2 nTPM (protected, limit 3)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142511,GPR32,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 2.9361% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.670639,0.25,0,80,unavailable,0,56.2,0,"parathyroid gland: 56.2 nTPM (protected, limit 3)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142511,GPR32,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 94.7368% (minimum 99%, Missing); bone marrow: 87.8049% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); pancreas: 94.7368% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 97.2973% (minimum 99%, Missing)",-0.2,0.00297297,-0.111951,0,80,unavailable,0.5,0.1,1.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142513,ACP4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.1,0.272973,0.128049,0,80,unavailable,0.5,0.1,1.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142513,ACP4,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.1,0.272973,0.128049,0,80,unavailable,0.5,0.1,1.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142513,ACP4,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.1,0.272973,0.128049,0,80,unavailable,0.5,0.1,1.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142513,ACP4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.1,0.272973,0.128049,0,80,unavailable,0.5,0.1,1.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142513,ACP4,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6755% (minimum 99%, Missing); amygdala: 90.9646% (minimum 99%, Missing); basal ganglia: 89.2216% (minimum 99%, Missing); cerebellum: 94.5431% (minimum 99%, Missing); cerebral cortex: 90.4126% (minimum 99%, Missing); choroid plexus: 96.6278% (minimum 99%, Missing); duodenum: 98.5450% (minimum 99%, Missing); heart muscle: 98.1555% (minimum 99%, Missing); hippocampal formation: 93.4755% (minimum 99%, Missing); hypothalamus: 89.8673% (minimum 99%, Missing); kidney: 95.6354% (minimum 99%, Missing); liver: 96.6278% (minimum 99%, Missing); lung: 98.8064% (minimum 99%, Missing); midbrain: 89.3285% (minimum 99%, Missing); pancreas: 97.0052% (minimum 99%, Missing); pituitary gland: 95.0255% (minimum 99%, Missing); retina: 98.4148% (minimum 99%, Missing); salivary gland: 96.7532% (minimum 97%, Missing); skeletal muscle: 95.3905% (minimum 99%, Missing); small intestine: 98.8064% (minimum 99%, Missing); spinal cord: 94.9045% (minimum 99%, Missing)",0.0213168,-0.00246753,-0.0977844,0,80,unavailable,9,2.5,2.2,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142530,GARIN5A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321317,0.267532,0.142216,0,80,unavailable,9,2.5,2.2,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142530,GARIN5A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321317,0.267532,0.142216,0,80,unavailable,9,2.5,2.2,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142530,GARIN5A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321317,0.267532,0.142216,0,80,unavailable,9,2.5,2.2,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142530,GARIN5A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321317,0.267532,0.142216,0,80,unavailable,9,2.5,2.2,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142530,GARIN5A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 16.6667% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); midbrain: 66.6667% (minimum 99%, Missing)",0.05,0.03,-0.823333,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000142538,PTH2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 16.6667% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.583333,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000142538,PTH2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 16.6667% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.583333,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000142538,PTH2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 16.6667% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.583333,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000142538,PTH2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 16.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.583333,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000142538,PTH2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 94.3396% (minimum 99%, Missing); basal ganglia: 91.4634% (minimum 99%, Missing); choroid plexus: 59.5238% (minimum 99%, Missing); duodenum: 94.9367% (minimum 95%, Enhanced); hippocampal formation: 90.3614% (minimum 99%, Missing); hypothalamus: 89.2857% (minimum 99%, Missing); lung: 81.0811% (minimum 95%, Enhanced); midbrain: 97.4026% (minimum 99%, Missing); parathyroid gland: 94.3396% (minimum 97%, Missing); pituitary gland: 96.1538% (minimum 99%, Missing); retina: 98.6842% (minimum 99%, Missing); small intestine: 93.7500% (minimum 95%, Enhanced); spinal cord: 97.4026% (minimum 99%, Missing)",0.0433775,-0.0266038,-0.394762,0,8,partial,10.2,2.2,1.2,"choroid plexus: 10.2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142621,FHAD1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 59.5238% (minimum 75%, Missing)",0.343377,0.243396,-0.154762,0,8,partial,10.2,2.2,1.2,"choroid plexus: 10.2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142621,FHAD1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 59.5238% (minimum 75%, Missing)",0.343377,0.243396,-0.154762,0,8,partial,10.2,2.2,1.2,"choroid plexus: 10.2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142621,FHAD1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 59.5238% (minimum 75%, Missing)",0.343377,0.243396,-0.154762,0,8,partial,10.2,2.2,1.2,"choroid plexus: 10.2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142621,FHAD1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 59.5238% (minimum 75%, Baseline (adaptation disabled))",0.275926,0.172093,-0.154762,0,8,partial,10.2,2.2,1.2,"choroid plexus: 10.2 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142621,FHAD1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2644% (minimum 95%, Missing); adrenal gland: 50.2423% (minimum 99%, Missing); amygdala: 53.8062% (minimum 99%, Missing); basal ganglia: 55.0442% (minimum 99%, Missing); bone marrow: 60.7422% (minimum 99%, Missing); cerebellum: 68.8053% (minimum 99%, Missing); cerebral cortex: 54.6573% (minimum 99%, Missing); choroid plexus: 43.1345% (minimum 99%, Missing); colon: 57.5926% (minimum 97%, Missing); duodenum: 71.1670% (minimum 99%, Missing); esophagus: 49.6013% (minimum 97%, Missing); heart muscle: 45.8702% (minimum 99%, Missing); hippocampal formation: 55.8348% (minimum 99%, Missing); hypothalamus: 52.4452% (minimum 99%, Missing); kidney: 44.3020% (minimum 99%, Missing); liver: 33.2976% (minimum 99%, Missing); lung: 59.5785% (minimum 99%, Missing); lymph node: 76.0391% (minimum 97%, Missing); midbrain: 52.0938% (minimum 99%, Missing); pancreas: 34.2511% (minimum 99%, Missing); parathyroid gland: 66.3113% (minimum 97%, Missing); pituitary gland: 55.4367% (minimum 99%, Missing); rectum: 83.8275% (minimum 97%, Missing); retina: 92.8358% (minimum 99%, Missing); salivary gland: 56.9597% (minimum 97%, Missing); skeletal muscle: 24.1460% (minimum 99%, Missing); skin: 49.7600% (minimum 95%, Missing); small intestine: 60.2713% (minimum 99%, Missing); smooth muscle: 82.2751% (minimum 99%, Missing); spinal cord: 60.9804% (minimum 99%, Missing); spleen: 53.0717% (minimum 95%, Missing); stomach: 45.0725% (minimum 97%, Missing); thymus: 87.3596% (minimum 95%, Missing); thyroid gland: 53.3448% (minimum 95%, Missing); tongue: 59.6929% (minimum 97%, Missing); urinary bladder: 55.7348% (minimum 97%, Missing)",-0.477356,-0.519275,-0.74854,0,5,partial,97.7,37.9,34.7,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 2); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (manageable, limit 5); esophagus: 31.6 nTPM (protected, limit 2); skin: 31.4 nTPM (manageable, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); spleen: 27.5 nTPM (manageable, limit 5); thyroid gland: 27.2 nTPM (manageable, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 2); hippocampal formation: 24.6 nTPM (vital, limit 1); salivary gland: 23.5 nTPM (protected, limit 2); colon: 22.9 nTPM (protected, limit 2); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 2); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 2); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 2); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142684,ZNF593,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2644% (minimum 65%, Missing); adrenal gland: 50.2423% (minimum 75%, Missing); amygdala: 53.8062% (minimum 75%, Missing); basal ganglia: 55.0442% (minimum 75%, Missing); bone marrow: 60.7422% (minimum 75%, Missing); cerebellum: 68.8053% (minimum 75%, Missing); cerebral cortex: 54.6573% (minimum 75%, Missing); choroid plexus: 43.1345% (minimum 75%, Missing); colon: 57.5926% (minimum 70%, Missing); duodenum: 71.1670% (minimum 75%, Missing); esophagus: 49.6013% (minimum 70%, Missing); heart muscle: 45.8702% (minimum 75%, Missing); hippocampal formation: 55.8348% (minimum 75%, Missing); hypothalamus: 52.4452% (minimum 75%, Missing); kidney: 44.3020% (minimum 75%, Missing); liver: 33.2976% (minimum 75%, Missing); lung: 59.5785% (minimum 75%, Missing); midbrain: 52.0938% (minimum 75%, Missing); pancreas: 34.2511% (minimum 75%, Missing); parathyroid gland: 66.3113% (minimum 70%, Missing); pituitary gland: 55.4367% (minimum 75%, Missing); salivary gland: 56.9597% (minimum 70%, Missing); skeletal muscle: 24.1460% (minimum 75%, Missing); skin: 49.7600% (minimum 65%, Missing); small intestine: 60.2713% (minimum 75%, Missing); spinal cord: 60.9804% (minimum 75%, Missing); spleen: 53.0717% (minimum 65%, Missing); stomach: 45.0725% (minimum 70%, Missing); thyroid gland: 53.3448% (minimum 65%, Missing); tongue: 59.6929% (minimum 70%, Missing); urinary bladder: 55.7348% (minimum 70%, Missing)",-0.177356,-0.249275,-0.50854,0,5,partial,97.7,37.9,34.7,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 2); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (manageable, limit 5); esophagus: 31.6 nTPM (protected, limit 2); skin: 31.4 nTPM (manageable, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); spleen: 27.5 nTPM (manageable, limit 5); thyroid gland: 27.2 nTPM (manageable, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 2); hippocampal formation: 24.6 nTPM (vital, limit 1); salivary gland: 23.5 nTPM (protected, limit 2); colon: 22.9 nTPM (protected, limit 2); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 2); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 2); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 2); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142684,ZNF593,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2644% (minimum 65%, Missing); adrenal gland: 50.2423% (minimum 75%, Missing); amygdala: 53.8062% (minimum 75%, Missing); basal ganglia: 55.0442% (minimum 75%, Missing); bone marrow: 60.7422% (minimum 75%, Missing); cerebellum: 68.8053% (minimum 75%, Missing); cerebral cortex: 54.6573% (minimum 75%, Missing); choroid plexus: 43.1345% (minimum 75%, Missing); colon: 57.5926% (minimum 70%, Missing); duodenum: 71.1670% (minimum 75%, Missing); esophagus: 49.6013% (minimum 70%, Missing); heart muscle: 45.8702% (minimum 75%, Missing); hippocampal formation: 55.8348% (minimum 75%, Missing); hypothalamus: 52.4452% (minimum 75%, Missing); kidney: 44.3020% (minimum 75%, Missing); liver: 33.2976% (minimum 75%, Missing); lung: 59.5785% (minimum 75%, Missing); midbrain: 52.0938% (minimum 75%, Missing); pancreas: 34.2511% (minimum 75%, Missing); parathyroid gland: 66.3113% (minimum 70%, Missing); pituitary gland: 55.4367% (minimum 75%, Missing); salivary gland: 56.9597% (minimum 70%, Missing); skeletal muscle: 24.1460% (minimum 75%, Missing); skin: 49.7600% (minimum 65%, Missing); small intestine: 60.2713% (minimum 75%, Missing); spinal cord: 60.9804% (minimum 75%, Missing); spleen: 53.0717% (minimum 65%, Missing); stomach: 45.0725% (minimum 70%, Missing); thyroid gland: 53.3448% (minimum 65%, Missing); tongue: 59.6929% (minimum 70%, Missing); urinary bladder: 55.7348% (minimum 70%, Missing)",-0.177356,-0.249275,-0.50854,0,5,partial,97.7,37.9,34.7,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 3); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (manageable, limit 5); esophagus: 31.6 nTPM (protected, limit 3); skin: 31.4 nTPM (manageable, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); spleen: 27.5 nTPM (manageable, limit 5); thyroid gland: 27.2 nTPM (manageable, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 3); hippocampal formation: 24.6 nTPM (vital, limit 1); salivary gland: 23.5 nTPM (protected, limit 3); colon: 22.9 nTPM (protected, limit 3); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 3); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 3); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 3); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142684,ZNF593,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2644% (minimum 65%, Missing); adrenal gland: 50.2423% (minimum 75%, Missing); amygdala: 53.8062% (minimum 75%, Missing); basal ganglia: 55.0442% (minimum 75%, Missing); bone marrow: 60.7422% (minimum 75%, Missing); cerebellum: 68.8053% (minimum 75%, Missing); cerebral cortex: 54.6573% (minimum 75%, Missing); choroid plexus: 43.1345% (minimum 75%, Missing); colon: 57.5926% (minimum 70%, Missing); duodenum: 71.1670% (minimum 75%, Missing); esophagus: 49.6013% (minimum 70%, Missing); heart muscle: 45.8702% (minimum 75%, Missing); hippocampal formation: 55.8348% (minimum 75%, Missing); hypothalamus: 52.4452% (minimum 75%, Missing); kidney: 44.3020% (minimum 75%, Missing); liver: 33.2976% (minimum 75%, Missing); lung: 59.5785% (minimum 75%, Missing); midbrain: 52.0938% (minimum 75%, Missing); pancreas: 34.2511% (minimum 75%, Missing); parathyroid gland: 66.3113% (minimum 70%, Missing); pituitary gland: 55.4367% (minimum 75%, Missing); salivary gland: 56.9597% (minimum 70%, Missing); skeletal muscle: 24.1460% (minimum 75%, Missing); skin: 49.7600% (minimum 65%, Missing); small intestine: 60.2713% (minimum 75%, Missing); spinal cord: 60.9804% (minimum 75%, Missing); spleen: 53.0717% (minimum 65%, Missing); stomach: 45.0725% (minimum 70%, Missing); thyroid gland: 53.3448% (minimum 65%, Missing); tongue: 59.6929% (minimum 70%, Missing); urinary bladder: 55.7348% (minimum 70%, Missing)",-0.177356,-0.249275,-0.50854,0,5,partial,97.7,37.9,34.7,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 3); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (manageable, limit 5); esophagus: 31.6 nTPM (protected, limit 3); skin: 31.4 nTPM (manageable, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); spleen: 27.5 nTPM (manageable, limit 5); thyroid gland: 27.2 nTPM (manageable, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 3); hippocampal formation: 24.6 nTPM (vital, limit 1); salivary gland: 23.5 nTPM (protected, limit 3); colon: 22.9 nTPM (protected, limit 3); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 3); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 3); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 3); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142684,ZNF593,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2644% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 50.2423% (minimum 75%, Baseline (adaptation disabled)); amygdala: 53.8062% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.0442% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 60.7422% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.8053% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 54.6573% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 43.1345% (minimum 75%, Baseline (adaptation disabled)); colon: 57.5926% (minimum 70%, Baseline (adaptation disabled)); duodenum: 71.1670% (minimum 75%, Baseline (adaptation disabled)); esophagus: 49.6013% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 45.8702% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.8348% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 52.4452% (minimum 75%, Baseline (adaptation disabled)); kidney: 44.3020% (minimum 75%, Baseline (adaptation disabled)); liver: 33.2976% (minimum 75%, Baseline (adaptation disabled)); lung: 59.5785% (minimum 75%, Baseline (adaptation disabled)); midbrain: 52.0938% (minimum 75%, Baseline (adaptation disabled)); pancreas: 34.2511% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.3113% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.4367% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.9597% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 24.1460% (minimum 75%, Baseline (adaptation disabled)); skin: 49.7600% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.2713% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 60.9804% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.0717% (minimum 65%, Baseline (adaptation disabled)); stomach: 45.0725% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.3448% (minimum 65%, Baseline (adaptation disabled)); tongue: 59.6929% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 55.7348% (minimum 70%, Baseline (adaptation disabled))",-0.177356,-0.249275,-0.50854,0,5,partial,97.7,37.9,34.7,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 3); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (manageable, limit 5); esophagus: 31.6 nTPM (protected, limit 3); skin: 31.4 nTPM (manageable, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); spleen: 27.5 nTPM (manageable, limit 5); thyroid gland: 27.2 nTPM (manageable, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 3); hippocampal formation: 24.6 nTPM (vital, limit 1); salivary gland: 23.5 nTPM (protected, limit 3); colon: 22.9 nTPM (protected, limit 3); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 3); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 3); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 3); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142684,ZNF593,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 96.9388% (minimum 99%, Missing); basal ganglia: 97.9381% (minimum 99%, Missing); cerebral cortex: 96.4467% (minimum 99%, Missing); hippocampal formation: 97.4359% (minimum 99%, Missing); hypothalamus: 96.9388% (minimum 99%, Missing); midbrain: 97.4359% (minimum 99%, Missing); spinal cord: 96.9388% (minimum 99%, Missing)",0.05,0.03,-0.025533,0,80,unavailable,0.7,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142698,C1orf94,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.214467,0,80,unavailable,0.7,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142698,C1orf94,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.214467,0,80,unavailable,0.7,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142698,C1orf94,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.214467,0,80,unavailable,0.7,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142698,C1orf94,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.214467,0,80,unavailable,0.7,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142698,C1orf94,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.6522% (minimum 98%, Approved); amygdala: 96.9163% (minimum 99%, Missing); basal ganglia: 96.0699% (minimum 99%, Missing); bone marrow: 49.6614% (minimum 99%, Missing); cerebral cortex: 96.0699% (minimum 99%, Missing); colon: 86.6142% (minimum 97%, Missing); duodenum: 89.0688% (minimum 99%, Missing); esophagus: 87.3016% (minimum 97%, Missing); heart muscle: 97.7778% (minimum 98%, Approved); hippocampal formation: 97.7778% (minimum 99%, Missing); hypothalamus: 97.3451% (minimum 99%, Missing); kidney: 97.3451% (minimum 99%, Missing); liver: 96.4912% (minimum 99%, Missing); lung: 96.0699% (minimum 99%, Missing); lymph node: 75.0853% (minimum 97%, Missing); midbrain: 97.3451% (minimum 99%, Missing); pancreas: 98.2143% (minimum 99%, Missing); rectum: 84.2912% (minimum 97%, Missing); retina: 91.6667% (minimum 99%, Missing); salivary gland: 96.0699% (minimum 97%, Missing); skin: 90.5350% (minimum 95%, Missing); small intestine: 88.7097% (minimum 99%, Missing); smooth muscle: 92.4370% (minimum 98%, Approved); spinal cord: 96.9163% (minimum 99%, Missing); spleen: 93.2203% (minimum 95%, Missing); stomach: 92.0502% (minimum 97%, Missing); thymus: 61.1111% (minimum 95%, Missing); urinary bladder: 94.4206% (minimum 95%, Approved)",-0.338889,-0.219147,-0.493386,0,1,partial,22.3,7.3,14,"bone marrow: 22.3 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 2); rectum: 4.1 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142731,PLK4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 49.6614% (minimum 75%, Missing); thymus: 61.1111% (minimum 65%, Missing)",-0.0388889,0.0508532,-0.253386,0,1,partial,22.3,7.3,14,"bone marrow: 22.3 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 2); rectum: 4.1 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142731,PLK4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 49.6614% (minimum 75%, Missing); thymus: 61.1111% (minimum 65%, Missing)",-0.0388889,0.0508532,-0.253386,0,1,partial,22.3,7.3,14,"bone marrow: 22.3 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 3); rectum: 4.1 nTPM (protected, limit 3); colon: 3.4 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142731,PLK4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 49.6614% (minimum 75%, Missing); thymus: 61.1111% (minimum 65%, Missing)",-0.0388889,0.0508532,-0.253386,0,1,partial,22.3,7.3,14,"bone marrow: 22.3 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 3); rectum: 4.1 nTPM (protected, limit 3); colon: 3.4 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142731,PLK4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 49.6614% (minimum 75%, Baseline (adaptation disabled)); thymus: 61.1111% (minimum 65%, Baseline (adaptation disabled))",-0.0388889,0.0508532,-0.253386,0,1,partial,22.3,7.3,14,"bone marrow: 22.3 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 3); rectum: 4.1 nTPM (protected, limit 3); colon: 3.4 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142731,PLK4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 89.3983% (minimum 99%, Missing); amygdala: 78.5894% (minimum 99%, Missing); basal ganglia: 76.2836% (minimum 99%, Missing); cerebellum: 82.5397% (minimum 99%, Missing); cerebral cortex: 72.5581% (minimum 99%, Missing); choroid plexus: 83.2000% (minimum 99%, Missing); colon: 90.1734% (minimum 97%, Missing); duodenum: 98.7342% (minimum 99%, Missing); heart muscle: 89.9135% (minimum 99%, Missing); hippocampal formation: 73.5849% (minimum 99%, Missing); hypothalamus: 78.5894% (minimum 99%, Missing); kidney: 92.3077% (minimum 99%, Missing); liver: 97.8056% (minimum 99%, Missing); lung: 96.0000% (minimum 99%, Missing); midbrain: 72.8972% (minimum 99%, Missing); pancreas: 95.1220% (minimum 99%, Missing); parathyroid gland: 90.6977% (minimum 97%, Missing); pituitary gland: 90.1734% (minimum 99%, Missing); rectum: 96.5944% (minimum 97%, Missing); retina: 91.4956% (minimum 99%, Missing); salivary gland: 93.6937% (minimum 97%, Missing); skeletal muscle: 96.8944% (minimum 99%, Missing); small intestine: 96.2963% (minimum 99%, Missing); smooth muscle: 96.0000% (minimum 99%, Missing); spinal cord: 59.0909% (minimum 99%, Missing); stomach: 96.8944% (minimum 97%, Missing); thyroid gland: 92.5816% (minimum 95%, Missing); tongue: 94.2598% (minimum 97%, Missing); urinary bladder: 95.7055% (minimum 97%, Missing)",-0.024184,-0.0682659,-0.399091,0,80,unavailable,21.6,3.4,2.5,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142920,AZIN2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 72.5581% (minimum 75%, Missing); hippocampal formation: 73.5849% (minimum 75%, Missing); midbrain: 72.8972% (minimum 75%, Missing); spinal cord: 59.0909% (minimum 75%, Missing)",0.275816,0.201734,-0.159091,0,80,unavailable,21.6,3.4,2.5,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142920,AZIN2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 72.5581% (minimum 75%, Missing); hippocampal formation: 73.5849% (minimum 75%, Missing); midbrain: 72.8972% (minimum 75%, Missing); spinal cord: 59.0909% (minimum 75%, Missing)",0.275816,0.201734,-0.159091,0,80,unavailable,21.6,3.4,2.5,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); pituitary gland: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142920,AZIN2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 72.5581% (minimum 75%, Missing); hippocampal formation: 73.5849% (minimum 75%, Missing); midbrain: 72.8972% (minimum 75%, Missing); spinal cord: 59.0909% (minimum 75%, Missing)",0.275816,0.201734,-0.159091,0,80,unavailable,21.6,3.4,2.5,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); pituitary gland: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142920,AZIN2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 72.5581% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.5849% (minimum 75%, Baseline (adaptation disabled)); midbrain: 72.8972% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.0909% (minimum 75%, Baseline (adaptation disabled))",0.275816,0.201734,-0.159091,0,80,unavailable,21.6,3.4,2.5,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); pituitary gland: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142920,AZIN2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5042% (minimum 99%, Missing); choroid plexus: 98.6720% (minimum 99%, Missing); colon: 92.5280% (minimum 97%, Missing); duodenum: 93.3417% (minimum 99%, Missing); lymph node: 82.1903% (minimum 97%, Missing); rectum: 90.9425% (minimum 97%, Missing); retina: 98.9348% (minimum 99%, Missing); small intestine: 93.6948% (minimum 99%, Missing); thymus: 67.1183% (minimum 95%, Missing)",-0.278817,-0.148097,-0.294958,0,12,partial,32.6,16.1,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6 nTPM (protected, limit 2); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142945,KIF2C,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5042% (minimum 75%, Missing)",0.0211834,0.121903,-0.0549579,0,12,partial,32.6,16.1,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6 nTPM (protected, limit 2); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142945,KIF2C,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5042% (minimum 75%, Missing)",0.0211834,0.121903,-0.0549579,0,12,partial,32.6,16.1,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6 nTPM (protected, limit 3); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142945,KIF2C,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5042% (minimum 75%, Missing)",0.0211834,0.121903,-0.0549579,0,12,partial,32.6,16.1,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6 nTPM (protected, limit 3); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142945,KIF2C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5042% (minimum 75%, Baseline (adaptation disabled))",0.0211834,0.121903,-0.0549579,0,12,partial,32.6,16.1,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); esophagus: 7.1 nTPM (protected, limit 3); colon: 6 nTPM (protected, limit 3); skin: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); smooth muscle: 3.1 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000142945,KIF2C,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143006,DMRTB1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143006,DMRTB1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143006,DMRTB1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143006,DMRTB1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348361,0.3,0.25,0,2,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143006,DMRTB1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.6522% (minimum 99%, Missing); cerebellum: 4.7722% (minimum 99%, Missing); cerebral cortex: 91.6667% (minimum 99%, Missing); choroid plexus: 95.6522% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); midbrain: 88.0000% (minimum 99%, Missing); retina: 44.8980% (minimum 99%, Missing); spinal cord: 75.8621% (minimum 99%, Missing)",0.05,0.03,-0.942278,0,80,unavailable,43.9,0,0,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143032,BARHL2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 4.7722% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); retina: 44.8980% (minimum 75%, Missing)",0.35,0.3,-0.702278,0,80,unavailable,43.9,0,0,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143032,BARHL2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 4.7722% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); retina: 44.8980% (minimum 75%, Missing)",0.35,0.3,-0.702278,0,80,unavailable,43.9,0,0,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143032,BARHL2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 4.7722% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); retina: 44.8980% (minimum 75%, Missing)",0.35,0.3,-0.702278,0,80,unavailable,43.9,0,0,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143032,BARHL2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 4.7722% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 44.8980% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.702278,0,80,unavailable,43.9,0,0,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143032,BARHL2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lung: 80.0000% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); thymus: 66.6667% (minimum 95%, Missing)",-0.283333,0.03,-0.19,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143105,KCNA10,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0166667,0.3,0.05,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143105,KCNA10,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0166667,0.3,0.05,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143105,KCNA10,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0166667,0.3,0.05,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143105,KCNA10,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0166667,0.3,0.05,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143105,KCNA10,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 84.6154% (minimum 99%, Missing); basal ganglia: 84.6154% (minimum 99%, Missing); bone marrow: 91.6667% (minimum 95%, Enhanced); cerebellum: 91.6667% (minimum 95%, Enhanced); cerebral cortex: 91.6667% (minimum 95%, Enhanced); hippocampal formation: 78.5714% (minimum 99%, Missing); hypothalamus: 84.6154% (minimum 99%, Missing); pituitary gland: 84.6154% (minimum 99%, Missing); retina: 73.3333% (minimum 99%, Missing); spinal cord: 91.6667% (minimum 99%, Missing)",0.05,0.03,-0.256667,0,4,partial,0.4,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143107,FNDC7,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 73.3333% (minimum 75%, Missing)",0.35,0.3,-0.0166667,0,4,partial,0.4,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143107,FNDC7,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 73.3333% (minimum 75%, Missing)",0.35,0.3,-0.0166667,0,4,partial,0.4,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143107,FNDC7,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 73.3333% (minimum 75%, Missing)",0.35,0.3,-0.0166667,0,4,partial,0.4,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143107,FNDC7,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 73.3333% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.0166667,0,4,partial,0.4,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143107,FNDC7,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.7229% (minimum 99%, Missing); cerebral cortex: 97.8481% (minimum 98%, Approved); heart muscle: 96.6250% (minimum 98%, Approved); hippocampal formation: 98.7229% (minimum 99%, Missing); retina: 97.3552% (minimum 99%, Missing)",0.0493536,0.0222978,-0.0164484,0,5,partial,5.4,1.2,0.1,"heart muscle: 5.4 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143194,MAEL,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349354,0.292298,0.223552,0,5,partial,5.4,1.2,0.1,"heart muscle: 5.4 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143194,MAEL,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349354,0.292298,0.223552,0,5,partial,5.4,1.2,0.1,"heart muscle: 5.4 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143194,MAEL,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349354,0.292298,0.223552,0,5,partial,5.4,1.2,0.1,"heart muscle: 5.4 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143194,MAEL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349354,0.292298,0.21625,0,5,partial,5.4,1.2,0.1,"heart muscle: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143194,MAEL,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8439% (minimum 99%, Missing); amygdala: 98.8439% (minimum 99%, Missing); basal ganglia: 98.2759% (minimum 99%, Missing); cerebellum: 91.9355% (minimum 98%, Approved); cerebral cortex: 97.7143% (minimum 99%, Missing); duodenum: 98.2759% (minimum 99%, Missing); hippocampal formation: 98.2759% (minimum 99%, Missing); hypothalamus: 98.2759% (minimum 99%, Missing); kidney: 97.7143% (minimum 99%, Missing); liver: 74.3478% (minimum 98%, Approved); lung: 98.8439% (minimum 99%, Missing); midbrain: 98.8439% (minimum 99%, Missing); pancreas: 97.7143% (minimum 99%, Missing); small intestine: 98.8439% (minimum 99%, Missing); spinal cord: 98.8439% (minimum 99%, Missing)",0.044186,0.0184393,-0.236522,0,3,partial,5.9,0.2,0.1,"liver: 5.9 nTPM (vital, limit 2)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143199,ADCY10,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344186,0.288439,0.0434783,0,3,partial,5.9,0.2,0.1,"liver: 5.9 nTPM (vital, limit 2)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143199,ADCY10,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344186,0.288439,0.0434783,0,3,partial,5.9,0.2,0.1,"liver: 5.9 nTPM (vital, limit 2)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143199,ADCY10,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344186,0.288439,0.0434783,0,3,partial,5.9,0.2,0.1,"liver: 5.9 nTPM (vital, limit 2)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143199,ADCY10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"liver: 74.3478% (minimum 75%, Baseline (adaptation disabled))",0.344186,0.288439,-0.00652174,0,3,partial,5.9,0.2,0.1,"liver: 5.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143199,ADCY10,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8593% (minimum 99%, Missing); bone marrow: 65.0000% (minimum 99%, Missing); cerebral cortex: 98.4848% (minimum 99%, Missing); colon: 92.6916% (minimum 97%, Missing); duodenum: 92.5267% (minimum 99%, Missing); esophagus: 90.2778% (minimum 97%, Missing); liver: 98.6717% (minimum 99%, Missing); lung: 98.2987% (minimum 99%, Missing); lymph node: 74.4986% (minimum 97%, Missing); midbrain: 98.8593% (minimum 99%, Missing); rectum: 91.0683% (minimum 97%, Missing); retina: 97.3783% (minimum 99%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 92.5267% (minimum 99%, Missing); smooth muscle: 95.9410% (minimum 99%, Missing); spinal cord: 98.2987% (minimum 99%, Missing); spleen: 93.6937% (minimum 95%, Missing); stomach: 95.4128% (minimum 97%, Missing); thymus: 67.2704% (minimum 95%, Missing); urinary bladder: 96.6543% (minimum 97%, Missing)",-0.277296,-0.225014,-0.34,0,80,unavailable,28,17.8,25.3,"bone marrow: 28 nTPM (vital, limit 1); thymus: 25.3 nTPM (manageable, limit 5); lymph node: 17.8 nTPM (protected, limit 2); esophagus: 5.6 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143228,NUF2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 65.0000% (minimum 75%, Missing)",0.0227038,0.0449857,-0.1,0,80,unavailable,28,17.8,25.3,"bone marrow: 28 nTPM (vital, limit 1); thymus: 25.3 nTPM (manageable, limit 5); lymph node: 17.8 nTPM (protected, limit 2); esophagus: 5.6 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143228,NUF2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 65.0000% (minimum 75%, Missing)",0.0227038,0.0449857,-0.1,0,80,unavailable,28,17.8,25.3,"bone marrow: 28 nTPM (vital, limit 1); thymus: 25.3 nTPM (manageable, limit 5); lymph node: 17.8 nTPM (protected, limit 3); esophagus: 5.6 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 3); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143228,NUF2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 65.0000% (minimum 75%, Missing)",0.0227038,0.0449857,-0.1,0,80,unavailable,28,17.8,25.3,"bone marrow: 28 nTPM (vital, limit 1); thymus: 25.3 nTPM (manageable, limit 5); lymph node: 17.8 nTPM (protected, limit 3); esophagus: 5.6 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 3); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143228,NUF2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 65.0000% (minimum 75%, Baseline (adaptation disabled))",0.0227038,0.0449857,-0.1,0,80,unavailable,28,17.8,25.3,"bone marrow: 28 nTPM (vital, limit 1); thymus: 25.3 nTPM (manageable, limit 5); lymph node: 17.8 nTPM (protected, limit 3); esophagus: 5.6 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 3); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143228,NUF2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9558% (minimum 99%, Missing); amygdala: 95.3488% (minimum 99%, Missing); basal ganglia: 90.4412% (minimum 99%, Missing); cerebellum: 97.6190% (minimum 99%, Missing); cerebral cortex: 83.6735% (minimum 99%, Missing); colon: 88.4892% (minimum 97%, Missing); duodenum: 91.7910% (minimum 99%, Missing); heart muscle: 96.0938% (minimum 99%, Missing); hippocampal formation: 98.4000% (minimum 99%, Missing); hypothalamus: 94.6154% (minimum 99%, Missing); lymph node: 95.3488% (minimum 97%, Missing); midbrain: 93.8931% (minimum 99%, Missing); pancreas: 96.8504% (minimum 99%, Missing); pituitary gland: 29.9270% (minimum 99%, Missing); rectum: 96.0938% (minimum 97%, Missing); retina: 94.6154% (minimum 99%, Missing); small intestine: 92.4812% (minimum 99%, Missing); smooth muscle: 96.8504% (minimum 99%, Missing); stomach: 93.1818% (minimum 97%, Missing); thymus: 44.0860% (minimum 95%, Missing); thyroid gland: 93.8931% (minimum 95%, Missing)",-0.50914,-0.0851079,-0.69073,0,80,unavailable,28.8,1.6,15.6,"pituitary gland: 28.8 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143340,FAM163A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9558% (minimum 75%, Missing); pituitary gland: 29.9270% (minimum 75%, Missing); thymus: 44.0860% (minimum 65%, Missing)",-0.20914,0.184892,-0.45073,0,80,unavailable,28.8,1.6,15.6,"pituitary gland: 28.8 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143340,FAM163A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9558% (minimum 75%, Missing); pituitary gland: 29.9270% (minimum 75%, Missing); thymus: 44.0860% (minimum 65%, Missing)",-0.20914,0.184892,-0.45073,0,80,unavailable,28.8,1.6,15.6,"pituitary gland: 28.8 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143340,FAM163A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9558% (minimum 75%, Missing); pituitary gland: 29.9270% (minimum 75%, Missing); thymus: 44.0860% (minimum 65%, Missing)",-0.20914,0.184892,-0.45073,0,80,unavailable,28.8,1.6,15.6,"pituitary gland: 28.8 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143340,FAM163A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9558% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 29.9270% (minimum 75%, Baseline (adaptation disabled)); thymus: 44.0860% (minimum 65%, Baseline (adaptation disabled))",-0.20914,0.184892,-0.45073,0,80,unavailable,28.8,1.6,15.6,"pituitary gland: 28.8 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143340,FAM163A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.3158% (minimum 99%, Missing); basal ganglia: 98.9189% (minimum 99%, Missing); choroid plexus: 96.8254% (minimum 99%, Missing); heart muscle: 97.8610% (minimum 99%, Missing); hippocampal formation: 98.9189% (minimum 99%, Missing); hypothalamus: 93.8462% (minimum 99%, Missing); liver: 97.8610% (minimum 99%, Missing); lung: 92.8934% (minimum 99%, Missing); midbrain: 98.9189% (minimum 99%, Missing); retina: 83.5616% (minimum 99%, Missing)",0.0445652,0.03,-0.154384,0,80,unavailable,3.6,0,0.1,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143355,LHX9,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344565,0.3,0.0856164,0,80,unavailable,3.6,0,0.1,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143355,LHX9,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344565,0.3,0.0856164,0,80,unavailable,3.6,0,0.1,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143355,LHX9,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344565,0.3,0.0856164,0,80,unavailable,3.6,0,0.1,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143355,LHX9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344565,0.3,0.0856164,0,80,unavailable,3.6,0,0.1,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143355,LHX9,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 88.2562% (minimum 95%, Enhanced); amygdala: 95.8763% (minimum 99%, Missing); basal ganglia: 95.6298% (minimum 99%, Missing); cerebellum: 94.1772% (minimum 95%, Enhanced); choroid plexus: 93.2331% (minimum 99%, Missing); heart muscle: 90.6212% (minimum 95%, Enhanced); hippocampal formation: 95.5071% (minimum 99%, Missing); hypothalamus: 95.7529% (minimum 99%, Missing); kidney: 92.0792% (minimum 99%, Missing); liver: 90.1818% (minimum 95%, Enhanced); midbrain: 95.3846% (minimum 99%, Missing); pancreas: 91.0649% (minimum 95%, Enhanced); pituitary gland: 88.4661% (minimum 99%, Missing); retina: 97.5098% (minimum 99%, Missing); skeletal muscle: 92.1933% (minimum 95%, Enhanced); spinal cord: 95.3846% (minimum 99%, Missing)",0.0446524,0.00127937,-0.105339,0,4,partial,9.9,5.3,7.9,"adrenal gland: 9.9 nTPM (vital, limit 6); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 6); heart muscle: 7.7 nTPM (vital, limit 6); pancreas: 7.3 nTPM (vital, limit 6); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); retina: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143443,C1orf56,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344652,0.271279,0.134661,0,4,partial,9.9,5.3,7.9,"adrenal gland: 9.9 nTPM (vital, limit 6); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 6); heart muscle: 7.7 nTPM (vital, limit 6); pancreas: 7.3 nTPM (vital, limit 6); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); retina: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143443,C1orf56,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344652,0.271279,0.134661,0,4,partial,9.9,5.3,7.9,"adrenal gland: 9.9 nTPM (vital, limit 6); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 6); heart muscle: 7.7 nTPM (vital, limit 6); pancreas: 7.3 nTPM (vital, limit 6); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143443,C1orf56,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344652,0.271279,0.134661,0,4,partial,9.9,5.3,7.9,"adrenal gland: 9.9 nTPM (vital, limit 6); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 6); heart muscle: 7.7 nTPM (vital, limit 6); pancreas: 7.3 nTPM (vital, limit 6); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143443,C1orf56,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.25401,0.233501,0.132562,0,4,partial,9.9,5.3,7.9,"adrenal gland: 9.9 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); thyroid gland: 7.9 nTPM (manageable, limit 5); heart muscle: 7.7 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); salivary gland: 5.3 nTPM (protected, limit 3); esophagus: 5.2 nTPM (protected, limit 3); urinary bladder: 5 nTPM (protected, limit 3); colon: 4.7 nTPM (protected, limit 3); cerebellum: 4.6 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); amygdala: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143443,C1orf56,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 98.9556% (minimum 99%, Missing); retina: 98.6465% (minimum 99%, Missing); salivary gland: 96.1929% (minimum 97%, Missing); skeletal muscle: 98.5439% (minimum 99%, Missing)",0.0390397,-0.00807107,-0.00456058,0,80,unavailable,2.8,7.5,2.1,"salivary gland: 7.5 nTPM (protected, limit 2); parathyroid gland: 4.1 nTPM (protected, limit 2); skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143450,OAZ3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33904,0.261929,0.235439,0,80,unavailable,2.8,7.5,2.1,"salivary gland: 7.5 nTPM (protected, limit 2); parathyroid gland: 4.1 nTPM (protected, limit 2); skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143450,OAZ3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33904,0.261929,0.235439,0,80,unavailable,2.8,7.5,2.1,"salivary gland: 7.5 nTPM (protected, limit 3); parathyroid gland: 4.1 nTPM (protected, limit 3); skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143450,OAZ3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33904,0.261929,0.235439,0,80,unavailable,2.8,7.5,2.1,"salivary gland: 7.5 nTPM (protected, limit 3); parathyroid gland: 4.1 nTPM (protected, limit 3); skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143450,OAZ3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33904,0.261929,0.235439,0,80,unavailable,2.8,7.5,2.1,"salivary gland: 7.5 nTPM (protected, limit 3); parathyroid gland: 4.1 nTPM (protected, limit 3); skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143450,OAZ3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00912587,0,3,partial,0.5,3.5,6.6,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143452,HORMAD1,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249126,0,3,partial,0.5,3.5,6.6,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143452,HORMAD1,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249126,0,3,partial,0.5,3.5,6.6,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143452,HORMAD1,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249126,0,3,partial,0.5,3.5,6.6,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143452,HORMAD1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.295409,0.270289,0.245645,0,3,partial,0.5,3.5,6.6,"skin: 6.6 nTPM (manageable, limit 5); esophagus: 3.5 nTPM (protected, limit 3)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143452,HORMAD1,current_fixed,True,False,False,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.1111% (minimum 99%, Missing); amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 94.1176% (minimum 99%, Missing); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 62.7451% (minimum 99%, Missing); hippocampal formation: 94.1176% (minimum 99%, Missing); hypothalamus: 94.1176% (minimum 99%, Missing); midbrain: 94.1176% (minimum 99%, Missing); pancreas: 91.4286% (minimum 99%, Missing); pituitary gland: 84.2105% (minimum 99%, Missing); retina: 45.7143% (minimum 99%, Missing); spinal cord: 94.1176% (minimum 99%, Missing); thyroid gland: 34.7826% (minimum 95%, Missing); tongue: 96.9697% (minimum 97%, Missing)",-0.602174,-0.00030303,-0.532857,0,80,unavailable,3.8,0.1,6,"thyroid gland: 6 nTPM (manageable, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143469,SYT14,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.1111% (minimum 75%, Missing); cerebral cortex: 62.7451% (minimum 75%, Missing); retina: 45.7143% (minimum 75%, Missing); thyroid gland: 34.7826% (minimum 65%, Missing)",-0.302174,0.269697,-0.292857,0,80,unavailable,3.8,0.1,6,"thyroid gland: 6 nTPM (manageable, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143469,SYT14,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.1111% (minimum 75%, Missing); cerebral cortex: 62.7451% (minimum 75%, Missing); retina: 45.7143% (minimum 75%, Missing); thyroid gland: 34.7826% (minimum 65%, Missing)",-0.302174,0.269697,-0.292857,0,80,unavailable,3.8,0.1,6,"thyroid gland: 6 nTPM (manageable, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143469,SYT14,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.1111% (minimum 75%, Missing); cerebral cortex: 62.7451% (minimum 75%, Missing); retina: 45.7143% (minimum 75%, Missing); thyroid gland: 34.7826% (minimum 65%, Missing)",-0.302174,0.269697,-0.292857,0,80,unavailable,3.8,0.1,6,"thyroid gland: 6 nTPM (manageable, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143469,SYT14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.1111% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.7451% (minimum 75%, Baseline (adaptation disabled)); retina: 45.7143% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 34.7826% (minimum 65%, Baseline (adaptation disabled))",-0.302174,0.269697,-0.292857,0,80,unavailable,3.8,0.1,6,"thyroid gland: 6 nTPM (manageable, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143469,SYT14,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 48.0144% (minimum 99%, Missing); colon: 80.6061% (minimum 90%, Supported); duodenum: 85.8065% (minimum 97%, Supported); esophagus: 87.5000% (minimum 97%, Missing); liver: 91.7241% (minimum 97%, Supported); lung: 90.4762% (minimum 99%, Missing); lymph node: 71.1230% (minimum 97%, Missing); pituitary gland: 98.5185% (minimum 99%, Missing); rectum: 74.3017% (minimum 90%, Supported); skin: 86.3636% (minimum 95%, Missing); small intestine: 82.0988% (minimum 97%, Supported); smooth muscle: 88.0795% (minimum 99%, Missing); thymus: 49.0775% (minimum 95%, Missing)",-0.459225,-0.25877,-0.509856,0,2,partial,14.4,5.4,13.8,"bone marrow: 14.4 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); lymph node: 5.4 nTPM (protected, limit 2); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); skin 2 / epidermal cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143476,DTL,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 48.0144% (minimum 75%, Missing); thymus: 49.0775% (minimum 65%, Missing)",-0.159225,0.0112299,-0.269856,0,2,partial,14.4,5.4,13.8,"bone marrow: 14.4 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); lymph node: 5.4 nTPM (protected, limit 2); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); skin 2 / epidermal cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143476,DTL,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 48.0144% (minimum 75%, Missing); thymus: 49.0775% (minimum 65%, Missing)",-0.159225,0.0112299,-0.269856,0,2,partial,14.4,5.4,13.8,"bone marrow: 14.4 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); lymph node: 5.4 nTPM (protected, limit 3); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); skin 2 / epidermal cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143476,DTL,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 48.0144% (minimum 75%, Missing); thymus: 49.0775% (minimum 65%, Missing)",-0.159225,0.0112299,-0.269856,0,2,partial,14.4,5.4,13.8,"bone marrow: 14.4 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); lymph node: 5.4 nTPM (protected, limit 3); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); skin 2 / epidermal cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143476,DTL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 48.0144% (minimum 75%, Baseline (adaptation disabled)); thymus: 49.0775% (minimum 65%, Baseline (adaptation disabled))",-0.159225,0.0112299,-0.269856,0,2,partial,14.4,5.4,13.8,"bone marrow: 14.4 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); lymph node: 5.4 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); colon: 3.2 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); skin 2 / epidermal cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143476,DTL,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.4312% (minimum 95%, Missing); adrenal gland: 95.2869% (minimum 99%, Missing); amygdala: 95.8763% (minimum 99%, Missing); basal ganglia: 96.0744% (minimum 99%, Missing); bone marrow: 84.2391% (minimum 99%, Missing); cerebellum: 98.5169% (minimum 99%, Missing); cerebral cortex: 94.8980% (minimum 99%, Missing); choroid plexus: 85.1648% (minimum 99%, Missing); colon: 95.2869% (minimum 97%, Missing); duodenum: 97.8947% (minimum 99%, Missing); esophagus: 94.5122% (minimum 97%, Missing); heart muscle: 85.3211% (minimum 99%, Missing); hippocampal formation: 94.5122% (minimum 99%, Missing); hypothalamus: 94.8980% (minimum 99%, Missing); kidney: 93.5614% (minimum 99%, Missing); liver: 92.0792% (minimum 99%, Missing); lung: 89.7683% (minimum 99%, Missing); lymph node: 96.6736% (minimum 97%, Missing); midbrain: 97.0772% (minimum 99%, Missing); pancreas: 92.6295% (minimum 99%, Missing); parathyroid gland: 94.1296% (minimum 97%, Missing); pituitary gland: 88.0682% (minimum 99%, Missing); retina: 88.2353% (minimum 99%, Missing); salivary gland: 91.8972% (minimum 97%, Missing); skeletal muscle: 98.3087% (minimum 99%, Missing); small intestine: 96.4730% (minimum 99%, Missing); smooth muscle: 85.4779% (minimum 99%, Missing); spinal cord: 98.1013% (minimum 99%, Missing); stomach: 93.9394% (minimum 97%, Missing); thymus: 88.9101% (minimum 95%, Missing); thyroid gland: 85.1648% (minimum 95%, Missing); tongue: 96.2733% (minimum 97%, Missing); urinary bladder: 86.5922% (minimum 97%, Missing)",-0.0983516,-0.104078,-0.147609,0,80,unavailable,8.7,7.2,8.1,"bone marrow: 8.7 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 2); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); esophagus: 2.7 nTPM (protected, limit 2); hippocampal formation: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143479,DYRK3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.201648,0.165922,0.0923913,0,80,unavailable,8.7,7.2,8.1,"bone marrow: 8.7 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 2); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); esophagus: 2.7 nTPM (protected, limit 2); hippocampal formation: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143479,DYRK3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.201648,0.165922,0.0923913,0,80,unavailable,8.7,7.2,8.1,"bone marrow: 8.7 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 3); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 3); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143479,DYRK3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.201648,0.165922,0.0923913,0,80,unavailable,8.7,7.2,8.1,"bone marrow: 8.7 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 3); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 3); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143479,DYRK3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.201648,0.165922,0.0923913,0,80,unavailable,8.7,7.2,8.1,"bone marrow: 8.7 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 3); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 3); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143479,DYRK3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 82.7957% (minimum 95%, Missing); adrenal gland: 98.7179% (minimum 99%, Missing); amygdala: 92.7711% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 89.5349% (minimum 99%, Missing); cerebellum: 96.2500% (minimum 99%, Missing); cerebral cortex: 90.5882% (minimum 99%, Missing); choroid plexus: 97.4684% (minimum 99%, Missing); colon: 93.9024% (minimum 97%, Missing); duodenum: 91.6667% (minimum 99%, Missing); esophagus: 66.3793% (minimum 97%, Missing); heart muscle: 87.5000% (minimum 99%, Missing); hippocampal formation: 95.0617% (minimum 99%, Missing); hypothalamus: 92.7711% (minimum 99%, Missing); kidney: 96.2500% (minimum 99%, Missing); liver: 97.4684% (minimum 99%, Missing); lung: 88.5057% (minimum 99%, Missing); lymph node: 77.7778% (minimum 97%, Missing); midbrain: 96.2500% (minimum 99%, Missing); pancreas: 97.4684% (minimum 99%, Missing); parathyroid gland: 90.5882% (minimum 97%, Missing); pituitary gland: 75.4902% (minimum 99%, Missing); rectum: 92.7711% (minimum 97%, Missing); retina: 93.9024% (minimum 99%, Missing); salivary gland: 90.5882% (minimum 97%, Missing); skeletal muscle: 93.9024% (minimum 99%, Missing); small intestine: 90.5882% (minimum 99%, Missing); smooth muscle: 81.9149% (minimum 99%, Missing); spinal cord: 97.4684% (minimum 99%, Missing); spleen: 86.5169% (minimum 95%, Missing); stomach: 91.6667% (minimum 97%, Missing); thymus: 65.2542% (minimum 95%, Missing); tongue: 90.5882% (minimum 97%, Missing); urinary bladder: 84.6154% (minimum 97%, Missing)",-0.297458,-0.306207,-0.235098,0,80,unavailable,2.5,3.9,4.1,"esophagus: 3.9 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143494,VASH2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 66.3793% (minimum 70%, Missing)",0.00254237,-0.0362069,0.00490196,0,80,unavailable,2.5,3.9,4.1,"esophagus: 3.9 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143494,VASH2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 66.3793% (minimum 70%, Missing)",0.00254237,-0.0362069,0.00490196,0,80,unavailable,2.5,3.9,4.1,"esophagus: 3.9 nTPM (protected, limit 3); pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143494,VASH2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 66.3793% (minimum 70%, Missing)",0.00254237,-0.0362069,0.00490196,0,80,unavailable,2.5,3.9,4.1,"esophagus: 3.9 nTPM (protected, limit 3); pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143494,VASH2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 66.3793% (minimum 70%, Baseline (adaptation disabled))",0.00254237,-0.0362069,0.00490196,0,80,unavailable,2.5,3.9,4.1,"esophagus: 3.9 nTPM (protected, limit 3); pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143494,VASH2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.7778% (minimum 90%, Approved); adrenal gland: 64.8936% (minimum 99%, Missing); amygdala: 80.2632% (minimum 99%, Missing); basal ganglia: 78.2051% (minimum 99%, Missing); bone marrow: 69.3182% (minimum 99%, Missing); cerebellum: 77.2152% (minimum 99%, Missing); cerebral cortex: 67.0330% (minimum 99%, Missing); choroid plexus: 83.5616% (minimum 99%, Missing); colon: 75.3086% (minimum 97%, Missing); duodenum: 71.7647% (minimum 99%, Missing); esophagus: 70.9302% (minimum 97%, Missing); heart muscle: 77.2152% (minimum 99%, Missing); hippocampal formation: 81.3333% (minimum 99%, Missing); hypothalamus: 74.3902% (minimum 99%, Missing); kidney: 75.3086% (minimum 99%, Missing); liver: 77.2152% (minimum 99%, Missing); lung: 69.3182% (minimum 99%, Missing); lymph node: 49.1935% (minimum 97%, Missing); midbrain: 78.2051% (minimum 99%, Missing); pancreas: 76.2500% (minimum 99%, Missing); parathyroid gland: 77.2152% (minimum 97%, Missing); pituitary gland: 71.7647% (minimum 99%, Missing); rectum: 70.9302% (minimum 97%, Missing); retina: 61.0000% (minimum 99%, Missing); salivary gland: 76.2500% (minimum 97%, Missing); skeletal muscle: 83.5616% (minimum 99%, Missing); skin: 75.3086% (minimum 95%, Missing); small intestine: 72.6190% (minimum 99%, Missing); smooth muscle: 71.7647% (minimum 99%, Missing); spinal cord: 75.3086% (minimum 99%, Missing); spleen: 58.6538% (minimum 95%, Missing); stomach: 64.8936% (minimum 97%, Missing); thymus: 58.6538% (minimum 95%, Missing); thyroid gland: 55.4545% (minimum 95%, Missing); tongue: 82.4324% (minimum 97%, Missing); urinary bladder: 54.4643% (minimum 97%, Missing)",-0.395455,-0.478065,-0.38,0,5,partial,3.9,6.3,4.9,"lymph node: 6.3 nTPM (protected, limit 2); urinary bladder: 5.1 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143498,TAF1A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 64.8936% (minimum 75%, Missing); bone marrow: 69.3182% (minimum 75%, Missing); cerebral cortex: 67.0330% (minimum 75%, Missing); duodenum: 71.7647% (minimum 75%, Missing); hypothalamus: 74.3902% (minimum 75%, Missing); lung: 69.3182% (minimum 75%, Missing); lymph node: 49.1935% (minimum 70%, Missing); pituitary gland: 71.7647% (minimum 75%, Missing); retina: 61.0000% (minimum 75%, Missing); small intestine: 72.6190% (minimum 75%, Missing); smooth muscle: 71.7647% (minimum 75%, Missing); spleen: 58.6538% (minimum 65%, Missing); stomach: 64.8936% (minimum 70%, Missing); thymus: 58.6538% (minimum 65%, Missing); thyroid gland: 55.4545% (minimum 65%, Missing); urinary bladder: 54.4643% (minimum 70%, Missing)",-0.0954545,-0.208065,-0.14,0,5,partial,3.9,6.3,4.9,"lymph node: 6.3 nTPM (protected, limit 2); urinary bladder: 5.1 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143498,TAF1A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 64.8936% (minimum 75%, Missing); bone marrow: 69.3182% (minimum 75%, Missing); cerebral cortex: 67.0330% (minimum 75%, Missing); duodenum: 71.7647% (minimum 75%, Missing); hypothalamus: 74.3902% (minimum 75%, Missing); lung: 69.3182% (minimum 75%, Missing); lymph node: 49.1935% (minimum 70%, Missing); pituitary gland: 71.7647% (minimum 75%, Missing); retina: 61.0000% (minimum 75%, Missing); small intestine: 72.6190% (minimum 75%, Missing); smooth muscle: 71.7647% (minimum 75%, Missing); spleen: 58.6538% (minimum 65%, Missing); stomach: 64.8936% (minimum 70%, Missing); thymus: 58.6538% (minimum 65%, Missing); thyroid gland: 55.4545% (minimum 65%, Missing); urinary bladder: 54.4643% (minimum 70%, Missing)",-0.0954545,-0.208065,-0.14,0,5,partial,3.9,6.3,4.9,"lymph node: 6.3 nTPM (protected, limit 3); urinary bladder: 5.1 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143498,TAF1A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 64.8936% (minimum 75%, Missing); bone marrow: 69.3182% (minimum 75%, Missing); cerebral cortex: 67.0330% (minimum 75%, Missing); duodenum: 71.7647% (minimum 75%, Missing); hypothalamus: 74.3902% (minimum 75%, Missing); lung: 69.3182% (minimum 75%, Missing); lymph node: 49.1935% (minimum 70%, Missing); pituitary gland: 71.7647% (minimum 75%, Missing); retina: 61.0000% (minimum 75%, Missing); small intestine: 72.6190% (minimum 75%, Missing); smooth muscle: 71.7647% (minimum 75%, Missing); spleen: 58.6538% (minimum 65%, Missing); stomach: 64.8936% (minimum 70%, Missing); thymus: 58.6538% (minimum 65%, Missing); thyroid gland: 55.4545% (minimum 65%, Missing); urinary bladder: 54.4643% (minimum 70%, Missing)",-0.0954545,-0.208065,-0.14,0,5,partial,3.9,6.3,4.9,"lymph node: 6.3 nTPM (protected, limit 3); urinary bladder: 5.1 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143498,TAF1A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 64.8936% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 69.3182% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 67.0330% (minimum 75%, Baseline (adaptation disabled)); duodenum: 71.7647% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.3902% (minimum 75%, Baseline (adaptation disabled)); lung: 69.3182% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.1935% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.7647% (minimum 75%, Baseline (adaptation disabled)); retina: 61.0000% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.6190% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.7647% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.6538% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.8936% (minimum 70%, Baseline (adaptation disabled)); thymus: 58.6538% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.4545% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 54.4643% (minimum 70%, Baseline (adaptation disabled))",-0.0954545,-0.208065,-0.14,0,5,partial,3.9,6.3,4.9,"lymph node: 6.3 nTPM (protected, limit 3); urinary bladder: 5.1 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143498,TAF1A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.0000% (minimum 95%, Enhanced); pituitary gland: 97.9167% (minimum 99%, Missing); retina: 97.9167% (minimum 99%, Missing)",0.05,0.0245614,-0.0108333,0,2,partial,0.3,1,1.9,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143512,HHIPL2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.212121,0.274561,0.229167,0,2,partial,0.3,1,1.9,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143512,HHIPL2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.212121,0.274561,0.229167,0,2,partial,0.3,1,1.9,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143512,HHIPL2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.212121,0.274561,0.229167,0,2,partial,0.3,1,1.9,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143512,HHIPL2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.0621212,0.124561,0.19,0,2,partial,0.3,1,1.9,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143512,HHIPL2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 97.7273% (minimum 99%, Missing); pituitary gland: 98.8506% (minimum 99%, Missing); retina: 98.4733% (minimum 99%, Missing)",0.05,0.03,-0.0127273,0,2,partial,0.6,0.3,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143552,NUP210L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.227273,0,2,partial,0.6,0.3,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143552,NUP210L,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.227273,0,2,partial,0.6,0.3,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143552,NUP210L,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.227273,0,2,partial,0.6,0.3,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143552,NUP210L,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342308,0.288506,0.227273,0,2,partial,0.6,0.3,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143552,NUP210L,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.7981% (minimum 95%, Uncertain); adrenal gland: 94.6855% (minimum 99%, Uncertain); amygdala: 93.0704% (minimum 99%, Missing); basal ganglia: 93.0704% (minimum 99%, Missing); bone marrow: 62.6705% (minimum 99%, Uncertain); cerebellum: 78.0161% (minimum 99%, Uncertain); cerebral cortex: 83.7812% (minimum 99%, Missing); choroid plexus: 96.6777% (minimum 99%, Missing); colon: 94.2765% (minimum 97%, Missing); duodenum: 96.6777% (minimum 99%, Missing); esophagus: 94.8913% (minimum 97%, Uncertain); heart muscle: 92.3810% (minimum 99%, Uncertain); hippocampal formation: 91.7981% (minimum 99%, Missing); hypothalamus: 90.8429% (minimum 99%, Missing); kidney: 97.1079% (minimum 99%, Uncertain); liver: 93.3690% (minimum 99%, Uncertain); lung: 91.3180% (minimum 99%, Missing); lymph node: 93.2692% (minimum 97%, Uncertain); midbrain: 90.0000% (minimum 99%, Missing); pancreas: 97.7604% (minimum 99%, Missing); pituitary gland: 95.4098% (minimum 99%, Missing); rectum: 96.7849% (minimum 97%, Missing); retina: 89.1726% (minimum 99%, Missing); salivary gland: 96.0396% (minimum 97%, Missing); skeletal muscle: 89.8148% (minimum 99%, Missing); small intestine: 95.4098% (minimum 99%, Missing); smooth muscle: 93.5691% (minimum 99%, Uncertain); spinal cord: 78.6486% (minimum 99%, Missing); spleen: 92.9712% (minimum 95%, Uncertain); stomach: 96.4641% (minimum 97%, Missing); thymus: 89.2638% (minimum 95%, Missing); thyroid gland: 87.9154% (minimum 95%, Missing); tongue: 93.9720% (minimum 97%, Missing); urinary bladder: 93.2692% (minimum 97%, Uncertain)",-0.0708459,-0.0373077,-0.363295,0,5,partial,52,6.3,12,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (manageable, limit 5); retina: 10.6 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); heart muscle: 7.2 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); basal ganglia: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); lymph node: 6.3 nTPM (protected, limit 2); urinary bladder: 6.3 nTPM (protected, limit 2); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 2); colon: 5.3 nTPM (protected, limit 2); adrenal gland: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143702,CEP170,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.6705% (minimum 75%, Uncertain)",0.229154,0.232692,-0.123295,0,5,partial,52,6.3,12,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (manageable, limit 5); retina: 10.6 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); heart muscle: 7.2 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); basal ganglia: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); lymph node: 6.3 nTPM (protected, limit 2); urinary bladder: 6.3 nTPM (protected, limit 2); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 2); colon: 5.3 nTPM (protected, limit 2); adrenal gland: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143702,CEP170,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.6705% (minimum 75%, Uncertain)",0.229154,0.232692,-0.123295,0,5,partial,52,6.3,12,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (manageable, limit 5); retina: 10.6 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); heart muscle: 7.2 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); urinary bladder: 6.3 nTPM (protected, limit 3); lymph node: 6.3 nTPM (protected, limit 3); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 3); colon: 5.3 nTPM (protected, limit 3); adrenal gland: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143702,CEP170,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.6705% (minimum 75%, Uncertain)",0.229154,0.232692,-0.123295,0,5,partial,52,6.3,12,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (manageable, limit 5); retina: 10.6 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); heart muscle: 7.2 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); urinary bladder: 6.3 nTPM (protected, limit 3); lymph node: 6.3 nTPM (protected, limit 3); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 3); colon: 5.3 nTPM (protected, limit 3); adrenal gland: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143702,CEP170,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.6705% (minimum 75%, Baseline (adaptation disabled))",0.229154,0.232692,-0.123295,0,5,partial,52,6.3,12,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (manageable, limit 5); retina: 10.6 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); heart muscle: 7.2 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); urinary bladder: 6.3 nTPM (protected, limit 3); lymph node: 6.3 nTPM (protected, limit 3); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 3); colon: 5.3 nTPM (protected, limit 3); adrenal gland: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143702,CEP170,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 40.2827% (minimum 95%, Missing); adrenal gland: 57.8680% (minimum 99%, Missing); amygdala: 67.4556% (minimum 99%, Missing); basal ganglia: 69.9387% (minimum 99%, Missing); bone marrow: 26.0274% (minimum 99%, Missing); cerebellum: 73.0769% (minimum 99%, Missing); cerebral cortex: 62.2951% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 58.7629% (minimum 97%, Missing); duodenum: 56.7164% (minimum 99%, Missing); esophagus: 55.0725% (minimum 97%, Missing); heart muscle: 60.6383% (minimum 99%, Missing); hippocampal formation: 67.4556% (minimum 99%, Missing); hypothalamus: 67.0588% (minimum 99%, Missing); kidney: 56.1576% (minimum 99%, Missing); liver: 44.7059% (minimum 99%, Missing); lung: 56.1576% (minimum 99%, Missing); lymph node: 48.5106% (minimum 97%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 55.0725% (minimum 99%, Missing); parathyroid gland: 51.3514% (minimum 97%, Missing); pituitary gland: 73.0769% (minimum 99%, Missing); rectum: 56.4356% (minimum 97%, Missing); retina: 69.9387% (minimum 99%, Missing); salivary gland: 63.6872% (minimum 97%, Missing); skeletal muscle: 48.1013% (minimum 99%, Missing); skin: 52.2936% (minimum 95%, Missing); small intestine: 56.7164% (minimum 99%, Missing); smooth muscle: 54.8077% (minimum 99%, Missing); spinal cord: 61.9565% (minimum 99%, Missing); spleen: 53.0233% (minimum 95%, Missing); stomach: 60.3175% (minimum 97%, Missing); thymus: 33.9286% (minimum 95%, Missing); thyroid gland: 48.5106% (minimum 95%, Missing); tongue: 55.0725% (minimum 97%, Missing); urinary bladder: 50.4425% (minimum 97%, Missing)",-0.610714,-0.484894,-0.729726,0,1,partial,32.4,12.1,22.2,"bone marrow: 32.4 nTPM (vital, limit 1); thymus: 22.2 nTPM (manageable, limit 5); adipose tissue: 16.9 nTPM (manageable, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); lymph node: 12.1 nTPM (protected, limit 2); urinary bladder: 11.2 nTPM (protected, limit 2); parathyroid gland: 10.8 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); spleen: 10.1 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 2); tongue: 9.3 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 2); stomach: 7.5 nTPM (protected, limit 2); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); salivary gland: 6.5 nTPM (protected, limit 2); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143751,SDE2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 40.2827% (minimum 65%, Missing); adrenal gland: 57.8680% (minimum 75%, Missing); amygdala: 67.4556% (minimum 75%, Missing); basal ganglia: 69.9387% (minimum 75%, Missing); bone marrow: 26.0274% (minimum 75%, Missing); cerebellum: 73.0769% (minimum 75%, Missing); cerebral cortex: 62.2951% (minimum 75%, Missing); colon: 58.7629% (minimum 70%, Missing); duodenum: 56.7164% (minimum 75%, Missing); esophagus: 55.0725% (minimum 70%, Missing); heart muscle: 60.6383% (minimum 75%, Missing); hippocampal formation: 67.4556% (minimum 75%, Missing); hypothalamus: 67.0588% (minimum 75%, Missing); kidney: 56.1576% (minimum 75%, Missing); liver: 44.7059% (minimum 75%, Missing); lung: 56.1576% (minimum 75%, Missing); lymph node: 48.5106% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 55.0725% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 73.0769% (minimum 75%, Missing); rectum: 56.4356% (minimum 70%, Missing); retina: 69.9387% (minimum 75%, Missing); salivary gland: 63.6872% (minimum 70%, Missing); skeletal muscle: 48.1013% (minimum 75%, Missing); skin: 52.2936% (minimum 65%, Missing); small intestine: 56.7164% (minimum 75%, Missing); smooth muscle: 54.8077% (minimum 75%, Missing); spinal cord: 61.9565% (minimum 75%, Missing); spleen: 53.0233% (minimum 65%, Missing); stomach: 60.3175% (minimum 70%, Missing); thymus: 33.9286% (minimum 65%, Missing); thyroid gland: 48.5106% (minimum 65%, Missing); tongue: 55.0725% (minimum 70%, Missing); urinary bladder: 50.4425% (minimum 70%, Missing)",-0.310714,-0.214894,-0.489726,0,1,partial,32.4,12.1,22.2,"bone marrow: 32.4 nTPM (vital, limit 1); thymus: 22.2 nTPM (manageable, limit 5); adipose tissue: 16.9 nTPM (manageable, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); lymph node: 12.1 nTPM (protected, limit 2); urinary bladder: 11.2 nTPM (protected, limit 2); parathyroid gland: 10.8 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); spleen: 10.1 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 2); tongue: 9.3 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 2); stomach: 7.5 nTPM (protected, limit 2); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); salivary gland: 6.5 nTPM (protected, limit 2); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143751,SDE2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 40.2827% (minimum 65%, Missing); adrenal gland: 57.8680% (minimum 75%, Missing); amygdala: 67.4556% (minimum 75%, Missing); basal ganglia: 69.9387% (minimum 75%, Missing); bone marrow: 26.0274% (minimum 75%, Missing); cerebellum: 73.0769% (minimum 75%, Missing); cerebral cortex: 62.2951% (minimum 75%, Missing); colon: 58.7629% (minimum 70%, Missing); duodenum: 56.7164% (minimum 75%, Missing); esophagus: 55.0725% (minimum 70%, Missing); heart muscle: 60.6383% (minimum 75%, Missing); hippocampal formation: 67.4556% (minimum 75%, Missing); hypothalamus: 67.0588% (minimum 75%, Missing); kidney: 56.1576% (minimum 75%, Missing); liver: 44.7059% (minimum 75%, Missing); lung: 56.1576% (minimum 75%, Missing); lymph node: 48.5106% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 55.0725% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 73.0769% (minimum 75%, Missing); rectum: 56.4356% (minimum 70%, Missing); retina: 69.9387% (minimum 75%, Missing); salivary gland: 63.6872% (minimum 70%, Missing); skeletal muscle: 48.1013% (minimum 75%, Missing); skin: 52.2936% (minimum 65%, Missing); small intestine: 56.7164% (minimum 75%, Missing); smooth muscle: 54.8077% (minimum 75%, Missing); spinal cord: 61.9565% (minimum 75%, Missing); spleen: 53.0233% (minimum 65%, Missing); stomach: 60.3175% (minimum 70%, Missing); thymus: 33.9286% (minimum 65%, Missing); thyroid gland: 48.5106% (minimum 65%, Missing); tongue: 55.0725% (minimum 70%, Missing); urinary bladder: 50.4425% (minimum 70%, Missing)",-0.310714,-0.214894,-0.489726,0,1,partial,32.4,12.1,22.2,"bone marrow: 32.4 nTPM (vital, limit 1); thymus: 22.2 nTPM (manageable, limit 5); adipose tissue: 16.9 nTPM (manageable, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); lymph node: 12.1 nTPM (protected, limit 3); urinary bladder: 11.2 nTPM (protected, limit 3); parathyroid gland: 10.8 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); spleen: 10.1 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 3); tongue: 9.3 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 1); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 3); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 3); stomach: 7.5 nTPM (protected, limit 3); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); salivary gland: 6.5 nTPM (protected, limit 3); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143751,SDE2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 40.2827% (minimum 65%, Missing); adrenal gland: 57.8680% (minimum 75%, Missing); amygdala: 67.4556% (minimum 75%, Missing); basal ganglia: 69.9387% (minimum 75%, Missing); bone marrow: 26.0274% (minimum 75%, Missing); cerebellum: 73.0769% (minimum 75%, Missing); cerebral cortex: 62.2951% (minimum 75%, Missing); colon: 58.7629% (minimum 70%, Missing); duodenum: 56.7164% (minimum 75%, Missing); esophagus: 55.0725% (minimum 70%, Missing); heart muscle: 60.6383% (minimum 75%, Missing); hippocampal formation: 67.4556% (minimum 75%, Missing); hypothalamus: 67.0588% (minimum 75%, Missing); kidney: 56.1576% (minimum 75%, Missing); liver: 44.7059% (minimum 75%, Missing); lung: 56.1576% (minimum 75%, Missing); lymph node: 48.5106% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 55.0725% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 73.0769% (minimum 75%, Missing); rectum: 56.4356% (minimum 70%, Missing); retina: 69.9387% (minimum 75%, Missing); salivary gland: 63.6872% (minimum 70%, Missing); skeletal muscle: 48.1013% (minimum 75%, Missing); skin: 52.2936% (minimum 65%, Missing); small intestine: 56.7164% (minimum 75%, Missing); smooth muscle: 54.8077% (minimum 75%, Missing); spinal cord: 61.9565% (minimum 75%, Missing); spleen: 53.0233% (minimum 65%, Missing); stomach: 60.3175% (minimum 70%, Missing); thymus: 33.9286% (minimum 65%, Missing); thyroid gland: 48.5106% (minimum 65%, Missing); tongue: 55.0725% (minimum 70%, Missing); urinary bladder: 50.4425% (minimum 70%, Missing)",-0.310714,-0.214894,-0.489726,0,1,partial,32.4,12.1,22.2,"bone marrow: 32.4 nTPM (vital, limit 1); thymus: 22.2 nTPM (manageable, limit 5); adipose tissue: 16.9 nTPM (manageable, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); lymph node: 12.1 nTPM (protected, limit 3); urinary bladder: 11.2 nTPM (protected, limit 3); parathyroid gland: 10.8 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); spleen: 10.1 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 3); tongue: 9.3 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 1); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 3); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 3); stomach: 7.5 nTPM (protected, limit 3); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); salivary gland: 6.5 nTPM (protected, limit 3); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143751,SDE2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 40.2827% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 57.8680% (minimum 75%, Baseline (adaptation disabled)); amygdala: 67.4556% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 69.9387% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 26.0274% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.0769% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.2951% (minimum 75%, Baseline (adaptation disabled)); colon: 58.7629% (minimum 70%, Baseline (adaptation disabled)); duodenum: 56.7164% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.0725% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.6383% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.4556% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.0588% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.1576% (minimum 75%, Baseline (adaptation disabled)); liver: 44.7059% (minimum 75%, Baseline (adaptation disabled)); lung: 56.1576% (minimum 75%, Baseline (adaptation disabled)); lymph node: 48.5106% (minimum 70%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.0725% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.3514% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 73.0769% (minimum 75%, Baseline (adaptation disabled)); rectum: 56.4356% (minimum 70%, Baseline (adaptation disabled)); retina: 69.9387% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.6872% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 48.1013% (minimum 75%, Baseline (adaptation disabled)); skin: 52.2936% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.7164% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 54.8077% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.9565% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.0233% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.3175% (minimum 70%, Baseline (adaptation disabled)); thymus: 33.9286% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 48.5106% (minimum 65%, Baseline (adaptation disabled)); tongue: 55.0725% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 50.4425% (minimum 70%, Baseline (adaptation disabled))",-0.310714,-0.214894,-0.489726,0,1,partial,32.4,12.1,22.2,"bone marrow: 32.4 nTPM (vital, limit 1); thymus: 22.2 nTPM (manageable, limit 5); adipose tissue: 16.9 nTPM (manageable, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); lymph node: 12.1 nTPM (protected, limit 3); urinary bladder: 11.2 nTPM (protected, limit 3); parathyroid gland: 10.8 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); spleen: 10.1 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 3); tongue: 9.3 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 1); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 3); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 3); stomach: 7.5 nTPM (protected, limit 3); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); salivary gland: 6.5 nTPM (protected, limit 3); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143751,SDE2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 95%, Missing); adrenal gland: 58.2278% (minimum 99%, Uncertain); amygdala: 76.6667% (minimum 99%, Missing); basal ganglia: 69.6970% (minimum 99%, Missing); bone marrow: 38.6555% (minimum 99%, Uncertain); cerebellum: 77.9661% (minimum 99%, Missing); cerebral cortex: 53.4884% (minimum 99%, Missing); choroid plexus: 51.6854% (minimum 99%, Missing); colon: 76.6667% (minimum 97%, Missing); duodenum: 74.1935% (minimum 99%, Missing); esophagus: 71.8750% (minimum 97%, Missing); heart muscle: 50.0000% (minimum 99%, Missing); hippocampal formation: 73.0159% (minimum 99%, Missing); hypothalamus: 74.1935% (minimum 99%, Missing); kidney: 58.2278% (minimum 99%, Missing); liver: 67.6471% (minimum 99%, Uncertain); lung: 65.7143% (minimum 99%, Missing); lymph node: 59.7403% (minimum 97%, Missing); midbrain: 76.6667% (minimum 99%, Missing); pancreas: 76.6667% (minimum 99%, Missing); parathyroid gland: 62.1622% (minimum 97%, Missing); pituitary gland: 70.7692% (minimum 99%, Missing); rectum: 74.1935% (minimum 97%, Missing); retina: 28.5714% (minimum 99%, Missing); salivary gland: 69.6970% (minimum 97%, Missing); skeletal muscle: 48.9362% (minimum 99%, Missing); skin: 59.7403% (minimum 95%, Missing); small intestine: 75.4098% (minimum 99%, Missing); smooth muscle: 62.1622% (minimum 99%, Uncertain); spinal cord: 68.6567% (minimum 99%, Missing); spleen: 59.7403% (minimum 95%, Uncertain); stomach: 58.9744% (minimum 97%, Missing); thymus: 57.5000% (minimum 95%, Missing); thyroid gland: 58.9744% (minimum 95%, Missing); tongue: 62.1622% (minimum 97%, Missing); urinary bladder: 73.0159% (minimum 97%, Uncertain)",-0.438889,-0.380256,-0.704286,0,3,partial,11.5,3.2,4.4,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); tongue: 2.8 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143951,WDPCP,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 65%, Missing); adrenal gland: 58.2278% (minimum 75%, Uncertain); basal ganglia: 69.6970% (minimum 75%, Missing); bone marrow: 38.6555% (minimum 75%, Uncertain); cerebral cortex: 53.4884% (minimum 75%, Missing); choroid plexus: 51.6854% (minimum 75%, Missing); duodenum: 74.1935% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 75%, Missing); hippocampal formation: 73.0159% (minimum 75%, Missing); hypothalamus: 74.1935% (minimum 75%, Missing); kidney: 58.2278% (minimum 75%, Missing); liver: 67.6471% (minimum 75%, Uncertain); lung: 65.7143% (minimum 75%, Missing); lymph node: 59.7403% (minimum 70%, Missing); parathyroid gland: 62.1622% (minimum 70%, Missing); pituitary gland: 70.7692% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); salivary gland: 69.6970% (minimum 70%, Missing); skeletal muscle: 48.9362% (minimum 75%, Missing); skin: 59.7403% (minimum 65%, Missing); smooth muscle: 62.1622% (minimum 75%, Uncertain); spinal cord: 68.6567% (minimum 75%, Missing); spleen: 59.7403% (minimum 65%, Uncertain); stomach: 58.9744% (minimum 70%, Missing); thymus: 57.5000% (minimum 65%, Missing); thyroid gland: 58.9744% (minimum 65%, Missing); tongue: 62.1622% (minimum 70%, Missing)",-0.138889,-0.110256,-0.464286,0,3,partial,11.5,3.2,4.4,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); tongue: 2.8 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143951,WDPCP,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 65%, Missing); adrenal gland: 58.2278% (minimum 75%, Uncertain); basal ganglia: 69.6970% (minimum 75%, Missing); bone marrow: 38.6555% (minimum 75%, Uncertain); cerebral cortex: 53.4884% (minimum 75%, Missing); choroid plexus: 51.6854% (minimum 75%, Missing); duodenum: 74.1935% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 75%, Missing); hippocampal formation: 73.0159% (minimum 75%, Missing); hypothalamus: 74.1935% (minimum 75%, Missing); kidney: 58.2278% (minimum 75%, Missing); liver: 67.6471% (minimum 75%, Uncertain); lung: 65.7143% (minimum 75%, Missing); lymph node: 59.7403% (minimum 70%, Missing); parathyroid gland: 62.1622% (minimum 70%, Missing); pituitary gland: 70.7692% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); salivary gland: 69.6970% (minimum 70%, Missing); skeletal muscle: 48.9362% (minimum 75%, Missing); skin: 59.7403% (minimum 65%, Missing); smooth muscle: 62.1622% (minimum 75%, Uncertain); spinal cord: 68.6567% (minimum 75%, Missing); spleen: 59.7403% (minimum 65%, Uncertain); stomach: 58.9744% (minimum 70%, Missing); thymus: 57.5000% (minimum 65%, Missing); thyroid gland: 58.9744% (minimum 65%, Missing); tongue: 62.1622% (minimum 70%, Missing)",-0.138889,-0.110256,-0.464286,0,3,partial,11.5,3.2,4.4,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); smooth muscle: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143951,WDPCP,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 65%, Missing); adrenal gland: 58.2278% (minimum 75%, Uncertain); basal ganglia: 69.6970% (minimum 75%, Missing); bone marrow: 38.6555% (minimum 75%, Uncertain); cerebral cortex: 53.4884% (minimum 75%, Missing); choroid plexus: 51.6854% (minimum 75%, Missing); duodenum: 74.1935% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 75%, Missing); hippocampal formation: 73.0159% (minimum 75%, Missing); hypothalamus: 74.1935% (minimum 75%, Missing); kidney: 58.2278% (minimum 75%, Missing); liver: 67.6471% (minimum 75%, Uncertain); lung: 65.7143% (minimum 75%, Missing); lymph node: 59.7403% (minimum 70%, Missing); parathyroid gland: 62.1622% (minimum 70%, Missing); pituitary gland: 70.7692% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); salivary gland: 69.6970% (minimum 70%, Missing); skeletal muscle: 48.9362% (minimum 75%, Missing); skin: 59.7403% (minimum 65%, Missing); smooth muscle: 62.1622% (minimum 75%, Uncertain); spinal cord: 68.6567% (minimum 75%, Missing); spleen: 59.7403% (minimum 65%, Uncertain); stomach: 58.9744% (minimum 70%, Missing); thymus: 57.5000% (minimum 65%, Missing); thyroid gland: 58.9744% (minimum 65%, Missing); tongue: 62.1622% (minimum 70%, Missing)",-0.138889,-0.110256,-0.464286,0,3,partial,11.5,3.2,4.4,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); smooth muscle: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143951,WDPCP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 58.2278% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 69.6970% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 38.6555% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.4884% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 51.6854% (minimum 75%, Baseline (adaptation disabled)); duodenum: 74.1935% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.0159% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.1935% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.2278% (minimum 75%, Baseline (adaptation disabled)); liver: 67.6471% (minimum 75%, Baseline (adaptation disabled)); lung: 65.7143% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.7403% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 62.1622% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.7692% (minimum 75%, Baseline (adaptation disabled)); retina: 28.5714% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 69.6970% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 48.9362% (minimum 75%, Baseline (adaptation disabled)); skin: 59.7403% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 62.1622% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.6567% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.7403% (minimum 65%, Baseline (adaptation disabled)); stomach: 58.9744% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.5000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.9744% (minimum 65%, Baseline (adaptation disabled)); tongue: 62.1622% (minimum 70%, Baseline (adaptation disabled))",-0.138889,-0.110256,-0.464286,0,3,partial,11.5,3.2,4.4,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); smooth muscle: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143951,WDPCP,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.2222% (minimum 99%, Missing); amygdala: 98.1308% (minimum 99%, Missing); basal ganglia: 97.2222% (minimum 99%, Missing); cerebral cortex: 97.6744% (minimum 99%, Missing); heart muscle: 97.6744% (minimum 99%, Missing); hippocampal formation: 98.5915% (minimum 99%, Missing); kidney: 98.5915% (minimum 99%, Missing); liver: 86.7769% (minimum 99%, Missing); midbrain: 98.1308% (minimum 99%, Missing); retina: 98.1308% (minimum 99%, Missing); salivary gland: 93.7500% (minimum 97%, Missing); skeletal muscle: 92.1053% (minimum 99%, Missing); smooth muscle: 98.5915% (minimum 99%, Missing); spinal cord: 98.5915% (minimum 99%, Missing); tongue: 92.9204% (minimum 97%, Missing)",0.000226244,-0.0407965,-0.122231,0,6,partial,3.2,1.6,1.1,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143994,ABHD1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.300226,0.229204,0.117769,0,6,partial,3.2,1.6,1.1,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143994,ABHD1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.300226,0.229204,0.117769,0,6,partial,3.2,1.6,1.1,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143994,ABHD1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.300226,0.229204,0.117769,0,6,partial,3.2,1.6,1.1,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143994,ABHD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.300226,0.229204,0.117769,0,6,partial,3.2,1.6,1.1,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000143994,ABHD1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebral cortex: 75.0000% (minimum 99%, Missing); thymus: 50.0000% (minimum 95%, Missing)",-0.45,0.03,-0.24,0,80,unavailable,0.1,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000144010,TRIM43B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebral cortex: 75.0000% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-1.11022e-16,0,80,unavailable,0.1,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000144010,TRIM43B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebral cortex: 75.0000% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-1.11022e-16,0,80,unavailable,0.1,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000144010,TRIM43B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebral cortex: 75.0000% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-1.11022e-16,0,80,unavailable,0.1,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000144010,TRIM43B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebral cortex: 75.0000% (minimum 75%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 65%, Baseline (adaptation disabled))",-0.15,0.3,-1.11022e-16,0,80,unavailable,0.1,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000144010,TRIM43B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 75.0000% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); stomach: 60.0000% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing)",-0.45,-0.37,-0.24,0,80,unavailable,0.1,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144015,TRIM43,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); stomach: 60.0000% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,-0.1,-1.11022e-16,0,80,unavailable,0.1,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144015,TRIM43,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); stomach: 60.0000% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,-0.1,-1.11022e-16,0,80,unavailable,0.1,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144015,TRIM43,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); stomach: 60.0000% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,-0.1,-1.11022e-16,0,80,unavailable,0.1,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144015,TRIM43,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 75.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 75.0000% (minimum 75%, Baseline (adaptation disabled)); stomach: 60.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 65%, Baseline (adaptation disabled))",-0.15,-0.1,-1.11022e-16,0,80,unavailable,0.1,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144015,TRIM43,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.9299% (minimum 90%, Approved); adrenal gland: 87.0036% (minimum 99%, Missing); amygdala: 83.1034% (minimum 99%, Missing); basal ganglia: 77.4920% (minimum 99%, Missing); cerebellum: 96.0159% (minimum 99%, Missing); cerebral cortex: 84.8592% (minimum 99%, Missing); choroid plexus: 39.3791% (minimum 99%, Missing); colon: 82.5342% (minimum 97%, Missing); duodenum: 96.4000% (minimum 99%, Missing); esophagus: 94.8819% (minimum 97%, Missing); heart muscle: 83.6806% (minimum 99%, Missing); hippocampal formation: 81.4189% (minimum 99%, Missing); hypothalamus: 76.2658% (minimum 99%, Missing); kidney: 75.5486% (minimum 99%, Missing); liver: 96.7871% (minimum 99%, Missing); lung: 85.1590% (minimum 99%, Missing); lymph node: 96.7871% (minimum 97%, Missing); midbrain: 86.3799% (minimum 99%, Missing); pancreas: 88.6029% (minimum 99%, Missing); parathyroid gland: 59.5062% (minimum 95%, Approved); pituitary gland: 67.8873% (minimum 99%, Missing); rectum: 93.4109% (minimum 97%, Missing); retina: 69.8551% (minimum 99%, Missing); salivary gland: 90.9434% (minimum 97%, Missing); skeletal muscle: 40.7783% (minimum 99%, Missing); skin: 93.4109% (minimum 95%, Missing); small intestine: 93.0502% (minimum 99%, Missing); smooth muscle: 84.2657% (minimum 99%, Missing); spinal cord: 87.0036% (minimum 99%, Missing); spleen: 93.0502% (minimum 95%, Missing); stomach: 87.3188% (minimum 97%, Missing); thyroid gland: 76.9968% (minimum 95%, Missing); tongue: 70.0581% (minimum 97%, Missing); urinary bladder: 85.7651% (minimum 97%, Missing)",-0.180032,-0.354938,-0.596209,0,4,partial,37.1,16.4,7.2,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 4); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 2); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144061,NPHP1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 39.3791% (minimum 75%, Missing); parathyroid gland: 59.5062% (minimum 65%, Approved); pituitary gland: 67.8873% (minimum 75%, Missing); retina: 69.8551% (minimum 75%, Missing); skeletal muscle: 40.7783% (minimum 75%, Missing)",0.119968,-0.0549383,-0.356209,0,4,partial,37.1,16.4,7.2,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 4); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 2); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144061,NPHP1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 39.3791% (minimum 75%, Missing); parathyroid gland: 59.5062% (minimum 65%, Approved); pituitary gland: 67.8873% (minimum 75%, Missing); retina: 69.8551% (minimum 75%, Missing); skeletal muscle: 40.7783% (minimum 75%, Missing)",0.119968,-0.0549383,-0.356209,0,4,partial,37.1,16.4,7.2,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 4); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 3); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); midbrain: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144061,NPHP1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 39.3791% (minimum 75%, Missing); parathyroid gland: 59.5062% (minimum 65%, Approved); pituitary gland: 67.8873% (minimum 75%, Missing); retina: 69.8551% (minimum 75%, Missing); skeletal muscle: 40.7783% (minimum 75%, Missing)",0.119968,-0.0549383,-0.356209,0,4,partial,37.1,16.4,7.2,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 4); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 3); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); midbrain: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144061,NPHP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 39.3791% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.5062% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.8873% (minimum 75%, Baseline (adaptation disabled)); retina: 69.8551% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 40.7783% (minimum 75%, Baseline (adaptation disabled))",0.119968,-0.104938,-0.356209,0,4,partial,37.1,16.4,7.2,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 3); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 3); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); midbrain: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144061,NPHP1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.5676% (minimum 99%, Missing); lung: 96.1538% (minimum 99%, Missing); lymph node: 75.7576% (minimum 97%, Missing); small intestine: 96.1538% (minimum 99%, Missing); spleen: 89.2857% (minimum 95%, Missing)",-0.0571429,-0.212424,-0.314324,0,80,unavailable,1.2,0.8,0.3,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144130,NT5DC4,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.5676% (minimum 75%, Missing)",0.242857,0.0575758,-0.0743243,0,80,unavailable,1.2,0.8,0.3,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144130,NT5DC4,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.5676% (minimum 75%, Missing)",0.242857,0.0575758,-0.0743243,0,80,unavailable,1.2,0.8,0.3,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144130,NT5DC4,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.5676% (minimum 75%, Missing)",0.242857,0.0575758,-0.0743243,0,80,unavailable,1.2,0.8,0.3,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144130,NT5DC4,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.5676% (minimum 75%, Baseline (adaptation disabled))",0.242857,0.0575758,-0.0743243,0,80,unavailable,1.2,0.8,0.3,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144130,NT5DC4,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 66.5049% (minimum 95%, Missing); adrenal gland: 64.6226% (minimum 99%, Missing); amygdala: 72.1053% (minimum 99%, Missing); basal ganglia: 69.5431% (minimum 99%, Missing); bone marrow: 52.8958% (minimum 98%, Approved); cerebellum: 71.7277% (minimum 98%, Approved); cerebral cortex: 74.8634% (minimum 99%, Missing); choroid plexus: 77.8409% (minimum 99%, Missing); colon: 67.8218% (minimum 97%, Missing); duodenum: 62.8440% (minimum 99%, Missing); esophagus: 73.6559% (minimum 95%, Approved); heart muscle: 62.5571% (minimum 99%, Missing); hippocampal formation: 69.5431% (minimum 99%, Missing); hypothalamus: 72.4868% (minimum 99%, Missing); kidney: 55.6911% (minimum 99%, Missing); liver: 63.4259% (minimum 99%, Missing); lung: 71.3542% (minimum 98%, Approved); lymph node: 56.8465% (minimum 95%, Approved); midbrain: 66.5049% (minimum 99%, Missing); pancreas: 66.1836% (minimum 99%, Missing); parathyroid gland: 69.1919% (minimum 95%, Approved); pituitary gland: 67.8218% (minimum 99%, Missing); rectum: 66.1836% (minimum 97%, Missing); retina: 65.2381% (minimum 99%, Missing); salivary gland: 61.1607% (minimum 95%, Approved); skeletal muscle: 60.8889% (minimum 99%, Missing); skin: 66.8293% (minimum 95%, Missing); small intestine: 62.8440% (minimum 98%, Approved); smooth muscle: 71.7277% (minimum 98%, Approved); spinal cord: 65.5502% (minimum 99%, Missing); spleen: 54.1502% (minimum 90%, Approved); stomach: 67.1569% (minimum 97%, Missing); thymus: 72.4868% (minimum 95%, Missing); thyroid gland: 55.4656% (minimum 90%, Approved); tongue: 61.4350% (minimum 97%, Missing); urinary bladder: 69.1919% (minimum 97%, Missing)",-0.358498,-0.381535,-0.451042,0,7,partial,12.2,10.4,11.6,"bone marrow: 12.2 nTPM (vital, limit 2); spleen: 11.6 nTPM (manageable, limit 10); thyroid gland: 11 nTPM (manageable, limit 10); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 4); skeletal muscle: 8.8 nTPM (vital, limit 1); salivary gland: 8.7 nTPM (protected, limit 4); tongue: 8.6 nTPM (protected, limit 2); heart muscle: 8.2 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 2); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 2); pancreas: 7 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (manageable, limit 5); midbrain: 6.9 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); stomach: 6.7 nTPM (protected, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); parathyroid gland: 6.1 nTPM (protected, limit 4); basal ganglia: 6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 2); smooth muscle: 5.4 nTPM (vital, limit 2); cerebellum: 5.4 nTPM (vital, limit 2); amygdala: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 4); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144182,LIPT1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.6226% (minimum 75%, Missing); amygdala: 72.1053% (minimum 75%, Missing); basal ganglia: 69.5431% (minimum 75%, Missing); bone marrow: 52.8958% (minimum 70%, Approved); cerebral cortex: 74.8634% (minimum 75%, Missing); colon: 67.8218% (minimum 70%, Missing); duodenum: 62.8440% (minimum 75%, Missing); heart muscle: 62.5571% (minimum 75%, Missing); hippocampal formation: 69.5431% (minimum 75%, Missing); hypothalamus: 72.4868% (minimum 75%, Missing); kidney: 55.6911% (minimum 75%, Missing); liver: 63.4259% (minimum 75%, Missing); lymph node: 56.8465% (minimum 65%, Approved); midbrain: 66.5049% (minimum 75%, Missing); pancreas: 66.1836% (minimum 75%, Missing); pituitary gland: 67.8218% (minimum 75%, Missing); rectum: 66.1836% (minimum 70%, Missing); retina: 65.2381% (minimum 75%, Missing); salivary gland: 61.1607% (minimum 65%, Approved); skeletal muscle: 60.8889% (minimum 75%, Missing); small intestine: 62.8440% (minimum 70%, Approved); spinal cord: 65.5502% (minimum 75%, Missing); spleen: 54.1502% (minimum 60%, Approved); stomach: 67.1569% (minimum 70%, Missing); thyroid gland: 55.4656% (minimum 60%, Approved); tongue: 61.4350% (minimum 70%, Missing); urinary bladder: 69.1919% (minimum 70%, Missing)",-0.058498,-0.0856502,-0.193089,0,7,partial,12.2,10.4,11.6,"bone marrow: 12.2 nTPM (vital, limit 2); spleen: 11.6 nTPM (manageable, limit 10); thyroid gland: 11 nTPM (manageable, limit 10); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 4); skeletal muscle: 8.8 nTPM (vital, limit 1); salivary gland: 8.7 nTPM (protected, limit 4); tongue: 8.6 nTPM (protected, limit 2); heart muscle: 8.2 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 2); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 2); pancreas: 7 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (manageable, limit 5); midbrain: 6.9 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); stomach: 6.7 nTPM (protected, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); parathyroid gland: 6.1 nTPM (protected, limit 4); basal ganglia: 6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 2); smooth muscle: 5.4 nTPM (vital, limit 2); cerebellum: 5.4 nTPM (vital, limit 2); amygdala: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 4); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144182,LIPT1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.6226% (minimum 75%, Missing); amygdala: 72.1053% (minimum 75%, Missing); basal ganglia: 69.5431% (minimum 75%, Missing); bone marrow: 52.8958% (minimum 70%, Approved); cerebral cortex: 74.8634% (minimum 75%, Missing); colon: 67.8218% (minimum 70%, Missing); duodenum: 62.8440% (minimum 75%, Missing); heart muscle: 62.5571% (minimum 75%, Missing); hippocampal formation: 69.5431% (minimum 75%, Missing); hypothalamus: 72.4868% (minimum 75%, Missing); kidney: 55.6911% (minimum 75%, Missing); liver: 63.4259% (minimum 75%, Missing); lymph node: 56.8465% (minimum 65%, Approved); midbrain: 66.5049% (minimum 75%, Missing); pancreas: 66.1836% (minimum 75%, Missing); pituitary gland: 67.8218% (minimum 75%, Missing); rectum: 66.1836% (minimum 70%, Missing); retina: 65.2381% (minimum 75%, Missing); salivary gland: 61.1607% (minimum 65%, Approved); skeletal muscle: 60.8889% (minimum 75%, Missing); small intestine: 62.8440% (minimum 70%, Approved); spinal cord: 65.5502% (minimum 75%, Missing); spleen: 54.1502% (minimum 60%, Approved); stomach: 67.1569% (minimum 70%, Missing); thyroid gland: 55.4656% (minimum 60%, Approved); tongue: 61.4350% (minimum 70%, Missing); urinary bladder: 69.1919% (minimum 70%, Missing)",-0.058498,-0.0856502,-0.193089,0,7,partial,12.2,10.4,11.6,"bone marrow: 12.2 nTPM (vital, limit 2); spleen: 11.6 nTPM (manageable, limit 10); thyroid gland: 11 nTPM (manageable, limit 10); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 4); skeletal muscle: 8.8 nTPM (vital, limit 1); salivary gland: 8.7 nTPM (protected, limit 4); tongue: 8.6 nTPM (protected, limit 3); heart muscle: 8.2 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 2); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 3); pancreas: 7 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (manageable, limit 5); midbrain: 6.9 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); stomach: 6.7 nTPM (protected, limit 3); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); parathyroid gland: 6.1 nTPM (protected, limit 4); basal ganglia: 6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 2); smooth muscle: 5.4 nTPM (vital, limit 2); cerebellum: 5.4 nTPM (vital, limit 2); amygdala: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 4); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144182,LIPT1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.6226% (minimum 75%, Missing); amygdala: 72.1053% (minimum 75%, Missing); basal ganglia: 69.5431% (minimum 75%, Missing); bone marrow: 52.8958% (minimum 70%, Approved); cerebral cortex: 74.8634% (minimum 75%, Missing); colon: 67.8218% (minimum 70%, Missing); duodenum: 62.8440% (minimum 75%, Missing); heart muscle: 62.5571% (minimum 75%, Missing); hippocampal formation: 69.5431% (minimum 75%, Missing); hypothalamus: 72.4868% (minimum 75%, Missing); kidney: 55.6911% (minimum 75%, Missing); liver: 63.4259% (minimum 75%, Missing); lymph node: 56.8465% (minimum 65%, Approved); midbrain: 66.5049% (minimum 75%, Missing); pancreas: 66.1836% (minimum 75%, Missing); pituitary gland: 67.8218% (minimum 75%, Missing); rectum: 66.1836% (minimum 70%, Missing); retina: 65.2381% (minimum 75%, Missing); salivary gland: 61.1607% (minimum 65%, Approved); skeletal muscle: 60.8889% (minimum 75%, Missing); small intestine: 62.8440% (minimum 70%, Approved); spinal cord: 65.5502% (minimum 75%, Missing); spleen: 54.1502% (minimum 60%, Approved); stomach: 67.1569% (minimum 70%, Missing); thyroid gland: 55.4656% (minimum 60%, Approved); tongue: 61.4350% (minimum 70%, Missing); urinary bladder: 69.1919% (minimum 70%, Missing)",-0.058498,-0.0856502,-0.193089,0,7,partial,12.2,10.4,11.6,"bone marrow: 12.2 nTPM (vital, limit 2); spleen: 11.6 nTPM (manageable, limit 10); thyroid gland: 11 nTPM (manageable, limit 10); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 4); skeletal muscle: 8.8 nTPM (vital, limit 1); salivary gland: 8.7 nTPM (protected, limit 4); tongue: 8.6 nTPM (protected, limit 3); heart muscle: 8.2 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 2); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 3); pancreas: 7 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (manageable, limit 5); midbrain: 6.9 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); stomach: 6.7 nTPM (protected, limit 3); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); parathyroid gland: 6.1 nTPM (protected, limit 4); basal ganglia: 6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 2); smooth muscle: 5.4 nTPM (vital, limit 2); cerebellum: 5.4 nTPM (vital, limit 2); amygdala: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 4); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144182,LIPT1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.6226% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.1053% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 69.5431% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 52.8958% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 71.7277% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.8634% (minimum 75%, Baseline (adaptation disabled)); colon: 67.8218% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.8440% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 62.5571% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 69.5431% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.4868% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.6911% (minimum 75%, Baseline (adaptation disabled)); liver: 63.4259% (minimum 75%, Baseline (adaptation disabled)); lung: 71.3542% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.8465% (minimum 70%, Baseline (adaptation disabled)); midbrain: 66.5049% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.1836% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.1919% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.8218% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.1836% (minimum 70%, Baseline (adaptation disabled)); retina: 65.2381% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.1607% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.8889% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.8440% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.7277% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.5502% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.1502% (minimum 65%, Baseline (adaptation disabled)); stomach: 67.1569% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 55.4656% (minimum 65%, Baseline (adaptation disabled)); tongue: 61.4350% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 69.1919% (minimum 70%, Baseline (adaptation disabled))",-0.108498,-0.131535,-0.221042,0,7,partial,12.2,10.4,11.6,"bone marrow: 12.2 nTPM (vital, limit 1); spleen: 11.6 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 3); skeletal muscle: 8.8 nTPM (vital, limit 1); salivary gland: 8.7 nTPM (protected, limit 3); tongue: 8.6 nTPM (protected, limit 3); heart muscle: 8.2 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 3); pancreas: 7 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (manageable, limit 5); midbrain: 6.9 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); stomach: 6.7 nTPM (protected, limit 3); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); parathyroid gland: 6.1 nTPM (protected, limit 3); basal ganglia: 6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 3); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144182,LIPT1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.9592% (minimum 99%, Missing); basal ganglia: 96.0000% (minimum 99%, Missing); bone marrow: 88.8889% (minimum 99%, Missing); duodenum: 97.9592% (minimum 99%, Missing); hippocampal formation: 97.9592% (minimum 99%, Missing); hypothalamus: 97.9592% (minimum 99%, Missing); kidney: 65.7534% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lymph node: 96.0000% (minimum 97%, Missing); midbrain: 97.9592% (minimum 99%, Missing); rectum: 96.0000% (minimum 97%, Missing); skeletal muscle: 97.9592% (minimum 99%, Missing); small intestine: 97.9592% (minimum 99%, Missing); spinal cord: 96.0000% (minimum 99%, Missing); thymus: 82.7586% (minimum 95%, Missing)",-0.122414,-0.01,-0.332466,0,80,unavailable,2.5,0.2,1,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144395,CCDC150,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 65.7534% (minimum 75%, Missing)",0.177586,0.26,-0.0924658,0,80,unavailable,2.5,0.2,1,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144395,CCDC150,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 65.7534% (minimum 75%, Missing)",0.177586,0.26,-0.0924658,0,80,unavailable,2.5,0.2,1,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144395,CCDC150,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 65.7534% (minimum 75%, Missing)",0.177586,0.26,-0.0924658,0,80,unavailable,2.5,0.2,1,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144395,CCDC150,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 65.7534% (minimum 75%, Baseline (adaptation disabled))",0.177586,0.26,-0.0924658,0,80,unavailable,2.5,0.2,1,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144395,CCDC150,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.6296% (minimum 95%, Missing); adrenal gland: 57.5610% (minimum 99%, Missing); amygdala: 42.4460% (minimum 99%, Missing); basal ganglia: 40.1361% (minimum 99%, Missing); bone marrow: 34.8083% (minimum 99%, Missing); cerebellum: 47.7733% (minimum 99%, Missing); cerebral cortex: 40.8304% (minimum 99%, Missing); choroid plexus: 45.5598% (minimum 99%, Missing); colon: 57.0048% (minimum 97%, Missing); duodenum: 62.4339% (minimum 99%, Missing); esophagus: 64.4809% (minimum 97%, Missing); heart muscle: 47.2000% (minimum 99%, Missing); hippocampal formation: 44.0299% (minimum 99%, Missing); hypothalamus: 43.2234% (minimum 99%, Missing); kidney: 51.9824% (minimum 99%, Missing); liver: 33.8109% (minimum 99%, Missing); lung: 59.5960% (minimum 99%, Missing); lymph node: 42.4460% (minimum 97%, Missing); midbrain: 38.5621% (minimum 99%, Missing); pancreas: 57.8431% (minimum 99%, Missing); parathyroid gland: 55.3991% (minimum 97%, Uncertain); pituitary gland: 55.1402% (minimum 99%, Missing); rectum: 57.8431% (minimum 97%, Missing); retina: 45.3846% (minimum 99%, Missing); salivary gland: 60.2041% (minimum 97%, Missing); skeletal muscle: 44.0299% (minimum 99%, Uncertain); skin: 73.7500% (minimum 95%, Missing); small intestine: 57.8431% (minimum 99%, Missing); smooth muscle: 61.4583% (minimum 99%, Missing); spinal cord: 37.3418% (minimum 99%, Missing); spleen: 45.0382% (minimum 95%, Missing); stomach: 52.6786% (minimum 97%, Missing); thymus: 40.6897% (minimum 95%, Missing); thyroid gland: 49.7890% (minimum 95%, Missing); tongue: 58.1281% (minimum 97%, Missing); urinary bladder: 59.0000% (minimum 97%, Missing)",-0.543103,-0.54554,-0.651891,0,1,partial,23.1,16,17.2,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); thymus: 17.2 nTPM (manageable, limit 5); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 2); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); spleen: 14.4 nTPM (manageable, limit 5); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 2); adipose tissue: 9.8 nTPM (manageable, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 2); colon: 8.9 nTPM (protected, limit 2); adrenal gland: 8.7 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 2); pancreas: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 2); urinary bladder: 8.2 nTPM (protected, limit 2); lung: 8 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 2); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); esophagus: 6.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144401,METTL21A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.6296% (minimum 65%, Missing); adrenal gland: 57.5610% (minimum 75%, Missing); amygdala: 42.4460% (minimum 75%, Missing); basal ganglia: 40.1361% (minimum 75%, Missing); bone marrow: 34.8083% (minimum 75%, Missing); cerebellum: 47.7733% (minimum 75%, Missing); cerebral cortex: 40.8304% (minimum 75%, Missing); choroid plexus: 45.5598% (minimum 75%, Missing); colon: 57.0048% (minimum 70%, Missing); duodenum: 62.4339% (minimum 75%, Missing); esophagus: 64.4809% (minimum 70%, Missing); heart muscle: 47.2000% (minimum 75%, Missing); hippocampal formation: 44.0299% (minimum 75%, Missing); hypothalamus: 43.2234% (minimum 75%, Missing); kidney: 51.9824% (minimum 75%, Missing); liver: 33.8109% (minimum 75%, Missing); lung: 59.5960% (minimum 75%, Missing); lymph node: 42.4460% (minimum 70%, Missing); midbrain: 38.5621% (minimum 75%, Missing); pancreas: 57.8431% (minimum 75%, Missing); parathyroid gland: 55.3991% (minimum 70%, Uncertain); pituitary gland: 55.1402% (minimum 75%, Missing); rectum: 57.8431% (minimum 70%, Missing); retina: 45.3846% (minimum 75%, Missing); salivary gland: 60.2041% (minimum 70%, Missing); skeletal muscle: 44.0299% (minimum 75%, Uncertain); small intestine: 57.8431% (minimum 75%, Missing); smooth muscle: 61.4583% (minimum 75%, Missing); spinal cord: 37.3418% (minimum 75%, Missing); spleen: 45.0382% (minimum 65%, Missing); stomach: 52.6786% (minimum 70%, Missing); thymus: 40.6897% (minimum 65%, Missing); thyroid gland: 49.7890% (minimum 65%, Missing); tongue: 58.1281% (minimum 70%, Missing); urinary bladder: 59.0000% (minimum 70%, Missing)",-0.243103,-0.27554,-0.411891,0,1,partial,23.1,16,17.2,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); thymus: 17.2 nTPM (manageable, limit 5); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 2); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); spleen: 14.4 nTPM (manageable, limit 5); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 2); adipose tissue: 9.8 nTPM (manageable, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 2); colon: 8.9 nTPM (protected, limit 2); adrenal gland: 8.7 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 2); pancreas: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 2); urinary bladder: 8.2 nTPM (protected, limit 2); lung: 8 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 2); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); esophagus: 6.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144401,METTL21A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.6296% (minimum 65%, Missing); adrenal gland: 57.5610% (minimum 75%, Missing); amygdala: 42.4460% (minimum 75%, Missing); basal ganglia: 40.1361% (minimum 75%, Missing); bone marrow: 34.8083% (minimum 75%, Missing); cerebellum: 47.7733% (minimum 75%, Missing); cerebral cortex: 40.8304% (minimum 75%, Missing); choroid plexus: 45.5598% (minimum 75%, Missing); colon: 57.0048% (minimum 70%, Missing); duodenum: 62.4339% (minimum 75%, Missing); esophagus: 64.4809% (minimum 70%, Missing); heart muscle: 47.2000% (minimum 75%, Missing); hippocampal formation: 44.0299% (minimum 75%, Missing); hypothalamus: 43.2234% (minimum 75%, Missing); kidney: 51.9824% (minimum 75%, Missing); liver: 33.8109% (minimum 75%, Missing); lung: 59.5960% (minimum 75%, Missing); lymph node: 42.4460% (minimum 70%, Missing); midbrain: 38.5621% (minimum 75%, Missing); pancreas: 57.8431% (minimum 75%, Missing); parathyroid gland: 55.3991% (minimum 70%, Uncertain); pituitary gland: 55.1402% (minimum 75%, Missing); rectum: 57.8431% (minimum 70%, Missing); retina: 45.3846% (minimum 75%, Missing); salivary gland: 60.2041% (minimum 70%, Missing); skeletal muscle: 44.0299% (minimum 75%, Uncertain); small intestine: 57.8431% (minimum 75%, Missing); smooth muscle: 61.4583% (minimum 75%, Missing); spinal cord: 37.3418% (minimum 75%, Missing); spleen: 45.0382% (minimum 65%, Missing); stomach: 52.6786% (minimum 70%, Missing); thymus: 40.6897% (minimum 65%, Missing); thyroid gland: 49.7890% (minimum 65%, Missing); tongue: 58.1281% (minimum 70%, Missing); urinary bladder: 59.0000% (minimum 70%, Missing)",-0.243103,-0.27554,-0.411891,0,1,partial,23.1,16,17.2,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); thymus: 17.2 nTPM (manageable, limit 5); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 3); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); spleen: 14.4 nTPM (manageable, limit 5); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 3); adipose tissue: 9.8 nTPM (manageable, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 3); colon: 8.9 nTPM (protected, limit 3); adrenal gland: 8.7 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 3); pancreas: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 3); urinary bladder: 8.2 nTPM (protected, limit 3); lung: 8 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 3); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); esophagus: 6.5 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144401,METTL21A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.6296% (minimum 65%, Missing); adrenal gland: 57.5610% (minimum 75%, Missing); amygdala: 42.4460% (minimum 75%, Missing); basal ganglia: 40.1361% (minimum 75%, Missing); bone marrow: 34.8083% (minimum 75%, Missing); cerebellum: 47.7733% (minimum 75%, Missing); cerebral cortex: 40.8304% (minimum 75%, Missing); choroid plexus: 45.5598% (minimum 75%, Missing); colon: 57.0048% (minimum 70%, Missing); duodenum: 62.4339% (minimum 75%, Missing); esophagus: 64.4809% (minimum 70%, Missing); heart muscle: 47.2000% (minimum 75%, Missing); hippocampal formation: 44.0299% (minimum 75%, Missing); hypothalamus: 43.2234% (minimum 75%, Missing); kidney: 51.9824% (minimum 75%, Missing); liver: 33.8109% (minimum 75%, Missing); lung: 59.5960% (minimum 75%, Missing); lymph node: 42.4460% (minimum 70%, Missing); midbrain: 38.5621% (minimum 75%, Missing); pancreas: 57.8431% (minimum 75%, Missing); parathyroid gland: 55.3991% (minimum 70%, Uncertain); pituitary gland: 55.1402% (minimum 75%, Missing); rectum: 57.8431% (minimum 70%, Missing); retina: 45.3846% (minimum 75%, Missing); salivary gland: 60.2041% (minimum 70%, Missing); skeletal muscle: 44.0299% (minimum 75%, Uncertain); small intestine: 57.8431% (minimum 75%, Missing); smooth muscle: 61.4583% (minimum 75%, Missing); spinal cord: 37.3418% (minimum 75%, Missing); spleen: 45.0382% (minimum 65%, Missing); stomach: 52.6786% (minimum 70%, Missing); thymus: 40.6897% (minimum 65%, Missing); thyroid gland: 49.7890% (minimum 65%, Missing); tongue: 58.1281% (minimum 70%, Missing); urinary bladder: 59.0000% (minimum 70%, Missing)",-0.243103,-0.27554,-0.411891,0,1,partial,23.1,16,17.2,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); thymus: 17.2 nTPM (manageable, limit 5); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 3); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); spleen: 14.4 nTPM (manageable, limit 5); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 3); adipose tissue: 9.8 nTPM (manageable, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 3); colon: 8.9 nTPM (protected, limit 3); adrenal gland: 8.7 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 3); pancreas: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 3); urinary bladder: 8.2 nTPM (protected, limit 3); lung: 8 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 3); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); esophagus: 6.5 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144401,METTL21A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.6296% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 57.5610% (minimum 75%, Baseline (adaptation disabled)); amygdala: 42.4460% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 40.1361% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 34.8083% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 47.7733% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 40.8304% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 45.5598% (minimum 75%, Baseline (adaptation disabled)); colon: 57.0048% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.4339% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.4809% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 47.2000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 44.0299% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 43.2234% (minimum 75%, Baseline (adaptation disabled)); kidney: 51.9824% (minimum 75%, Baseline (adaptation disabled)); liver: 33.8109% (minimum 75%, Baseline (adaptation disabled)); lung: 59.5960% (minimum 75%, Baseline (adaptation disabled)); lymph node: 42.4460% (minimum 70%, Baseline (adaptation disabled)); midbrain: 38.5621% (minimum 75%, Baseline (adaptation disabled)); pancreas: 57.8431% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.3991% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.1402% (minimum 75%, Baseline (adaptation disabled)); rectum: 57.8431% (minimum 70%, Baseline (adaptation disabled)); retina: 45.3846% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.2041% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 44.0299% (minimum 75%, Baseline (adaptation disabled)); small intestine: 57.8431% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.4583% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 37.3418% (minimum 75%, Baseline (adaptation disabled)); spleen: 45.0382% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.6786% (minimum 70%, Baseline (adaptation disabled)); thymus: 40.6897% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 49.7890% (minimum 65%, Baseline (adaptation disabled)); tongue: 58.1281% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 59.0000% (minimum 70%, Baseline (adaptation disabled))",-0.243103,-0.27554,-0.411891,0,1,partial,23.1,16,17.2,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); thymus: 17.2 nTPM (manageable, limit 5); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 3); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); spleen: 14.4 nTPM (manageable, limit 5); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 3); adipose tissue: 9.8 nTPM (manageable, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 3); colon: 8.9 nTPM (protected, limit 3); adrenal gland: 8.7 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 3); pancreas: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 3); urinary bladder: 8.2 nTPM (protected, limit 3); lung: 8 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 3); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); esophagus: 6.5 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144401,METTL21A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 68.7151% (minimum 95%, Uncertain); adrenal gland: 75.4601% (minimum 99%, Missing); amygdala: 81.7276% (minimum 99%, Missing); basal ganglia: 80.6557% (minimum 99%, Missing); bone marrow: 81.7276% (minimum 99%, Missing); cerebellum: 75.4601% (minimum 99%, Missing); cerebral cortex: 82.5503% (minimum 99%, Missing); choroid plexus: 83.6735% (minimum 99%, Missing); colon: 71.9298% (minimum 97%, Missing); duodenum: 79.6117% (minimum 99%, Missing); esophagus: 78.5942% (minimum 97%, Missing); heart muscle: 72.3529% (minimum 99%, Missing); hippocampal formation: 80.6557% (minimum 99%, Missing); hypothalamus: 80.6557% (minimum 99%, Missing); kidney: 52.9032% (minimum 99%, Missing); liver: 72.9970% (minimum 99%, Missing); lung: 68.1440% (minimum 99%, Missing); lymph node: 79.0997% (minimum 97%, Missing); midbrain: 81.1881% (minimum 99%, Missing); pancreas: 62.5954% (minimum 99%, Missing); parathyroid gland: 11.3364% (minimum 97%, Missing); pituitary gland: 71.7201% (minimum 99%, Missing); rectum: 78.8462% (minimum 97%, Missing); retina: 66.8478% (minimum 99%, Missing); salivary gland: 71.7201% (minimum 97%, Missing); skeletal muscle: 67.9558% (minimum 99%, Missing); skin: 65.6000% (minimum 95%, Missing); small intestine: 78.8462% (minimum 99%, Missing); smooth muscle: 65.7754% (minimum 99%, Missing); spinal cord: 78.0952% (minimum 99%, Missing); spleen: 80.1303% (minimum 95%, Uncertain); stomach: 66.8478% (minimum 97%, Missing); thymus: 48.6166% (minimum 95%, Missing); thyroid gland: 56.2929% (minimum 95%, Missing); tongue: 58.1560% (minimum 97%, Missing); urinary bladder: 65.0794% (minimum 97%, Missing)",-0.463834,-0.856636,-0.460968,0,3,partial,21.9,192.4,26,"parathyroid gland: 192.4 nTPM (protected, limit 2); thymus: 26 nTPM (manageable, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); tongue: 17.7 nTPM (protected, limit 2); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 2); skin: 12.9 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 2); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); rectum: 6.6 nTPM (protected, limit 2); small intestine: 6.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144445,KANSL1L,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"heart muscle: 72.3529% (minimum 75%, Missing); kidney: 52.9032% (minimum 75%, Missing); liver: 72.9970% (minimum 75%, Missing); lung: 68.1440% (minimum 75%, Missing); pancreas: 62.5954% (minimum 75%, Missing); parathyroid gland: 11.3364% (minimum 70%, Missing); pituitary gland: 71.7201% (minimum 75%, Missing); retina: 66.8478% (minimum 75%, Missing); skeletal muscle: 67.9558% (minimum 75%, Missing); smooth muscle: 65.7754% (minimum 75%, Missing); stomach: 66.8478% (minimum 70%, Missing); thymus: 48.6166% (minimum 65%, Missing); thyroid gland: 56.2929% (minimum 65%, Missing); tongue: 58.1560% (minimum 70%, Missing); urinary bladder: 65.0794% (minimum 70%, Missing)",-0.163834,-0.586636,-0.220968,0,3,partial,21.9,192.4,26,"parathyroid gland: 192.4 nTPM (protected, limit 2); thymus: 26 nTPM (manageable, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); tongue: 17.7 nTPM (protected, limit 2); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 2); skin: 12.9 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 2); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); rectum: 6.6 nTPM (protected, limit 2); small intestine: 6.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144445,KANSL1L,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"heart muscle: 72.3529% (minimum 75%, Missing); kidney: 52.9032% (minimum 75%, Missing); liver: 72.9970% (minimum 75%, Missing); lung: 68.1440% (minimum 75%, Missing); pancreas: 62.5954% (minimum 75%, Missing); parathyroid gland: 11.3364% (minimum 70%, Missing); pituitary gland: 71.7201% (minimum 75%, Missing); retina: 66.8478% (minimum 75%, Missing); skeletal muscle: 67.9558% (minimum 75%, Missing); smooth muscle: 65.7754% (minimum 75%, Missing); stomach: 66.8478% (minimum 70%, Missing); thymus: 48.6166% (minimum 65%, Missing); thyroid gland: 56.2929% (minimum 65%, Missing); tongue: 58.1560% (minimum 70%, Missing); urinary bladder: 65.0794% (minimum 70%, Missing)",-0.163834,-0.586636,-0.220968,0,3,partial,21.9,192.4,26,"parathyroid gland: 192.4 nTPM (protected, limit 3); thymus: 26 nTPM (manageable, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); tongue: 17.7 nTPM (protected, limit 3); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 3); skin: 12.9 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 3); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); rectum: 6.6 nTPM (protected, limit 3); small intestine: 6.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144445,KANSL1L,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"heart muscle: 72.3529% (minimum 75%, Missing); kidney: 52.9032% (minimum 75%, Missing); liver: 72.9970% (minimum 75%, Missing); lung: 68.1440% (minimum 75%, Missing); pancreas: 62.5954% (minimum 75%, Missing); parathyroid gland: 11.3364% (minimum 70%, Missing); pituitary gland: 71.7201% (minimum 75%, Missing); retina: 66.8478% (minimum 75%, Missing); skeletal muscle: 67.9558% (minimum 75%, Missing); smooth muscle: 65.7754% (minimum 75%, Missing); stomach: 66.8478% (minimum 70%, Missing); thymus: 48.6166% (minimum 65%, Missing); thyroid gland: 56.2929% (minimum 65%, Missing); tongue: 58.1560% (minimum 70%, Missing); urinary bladder: 65.0794% (minimum 70%, Missing)",-0.163834,-0.586636,-0.220968,0,3,partial,21.9,192.4,26,"parathyroid gland: 192.4 nTPM (protected, limit 3); thymus: 26 nTPM (manageable, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); tongue: 17.7 nTPM (protected, limit 3); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 3); skin: 12.9 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 3); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); rectum: 6.6 nTPM (protected, limit 3); small intestine: 6.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144445,KANSL1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"heart muscle: 72.3529% (minimum 75%, Baseline (adaptation disabled)); kidney: 52.9032% (minimum 75%, Baseline (adaptation disabled)); liver: 72.9970% (minimum 75%, Baseline (adaptation disabled)); lung: 68.1440% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.5954% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 11.3364% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.7201% (minimum 75%, Baseline (adaptation disabled)); retina: 66.8478% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 67.9558% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.7754% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.8478% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.6166% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.2929% (minimum 65%, Baseline (adaptation disabled)); tongue: 58.1560% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.0794% (minimum 70%, Baseline (adaptation disabled))",-0.163834,-0.586636,-0.220968,0,3,partial,21.9,192.4,26,"parathyroid gland: 192.4 nTPM (protected, limit 3); thymus: 26 nTPM (manageable, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); tongue: 17.7 nTPM (protected, limit 3); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 3); skin: 12.9 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 3); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); rectum: 6.6 nTPM (protected, limit 3); small intestine: 6.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144445,KANSL1L,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 84.0000% (minimum 95%, Missing); adrenal gland: 87.5000% (minimum 99%, Missing); amygdala: 95.4545% (minimum 99%, Missing); basal ganglia: 91.3043% (minimum 99%, Missing); cerebellum: 33.8710% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); choroid plexus: 87.5000% (minimum 99%, Missing); colon: 72.4138% (minimum 97%, Missing); duodenum: 87.5000% (minimum 99%, Missing); esophagus: 95.4545% (minimum 97%, Missing); heart muscle: 77.7778% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); kidney: 87.5000% (minimum 99%, Missing); liver: 56.7568% (minimum 99%, Missing); lung: 91.3043% (minimum 99%, Missing); lymph node: 80.7692% (minimum 97%, Missing); midbrain: 95.4545% (minimum 99%, Missing); pancreas: 87.5000% (minimum 99%, Missing); pituitary gland: 51.2195% (minimum 99%, Missing); skeletal muscle: 91.3043% (minimum 99%, Missing); skin: 91.3043% (minimum 95%, Missing); small intestine: 38.1818% (minimum 99%, Missing); smooth muscle: 84.0000% (minimum 99%, Missing); spinal cord: 95.4545% (minimum 99%, Missing); spleen: 65.6250% (minimum 95%, Missing); stomach: 91.3043% (minimum 97%, Missing); thymus: 87.5000% (minimum 95%, Missing); thyroid gland: 70.0000% (minimum 95%, Missing); urinary bladder: 77.7778% (minimum 97%, Missing)",-0.29375,-0.245862,-0.65129,0,80,unavailable,4.1,0.8,1.1,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144488,ESPNL,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 33.8710% (minimum 75%, Missing); liver: 56.7568% (minimum 75%, Missing); pituitary gland: 51.2195% (minimum 75%, Missing); small intestine: 38.1818% (minimum 75%, Missing)",0.00625,0.0241379,-0.41129,0,80,unavailable,4.1,0.8,1.1,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144488,ESPNL,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 33.8710% (minimum 75%, Missing); liver: 56.7568% (minimum 75%, Missing); pituitary gland: 51.2195% (minimum 75%, Missing); small intestine: 38.1818% (minimum 75%, Missing)",0.00625,0.0241379,-0.41129,0,80,unavailable,4.1,0.8,1.1,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144488,ESPNL,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 33.8710% (minimum 75%, Missing); liver: 56.7568% (minimum 75%, Missing); pituitary gland: 51.2195% (minimum 75%, Missing); small intestine: 38.1818% (minimum 75%, Missing)",0.00625,0.0241379,-0.41129,0,80,unavailable,4.1,0.8,1.1,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144488,ESPNL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 33.8710% (minimum 75%, Baseline (adaptation disabled)); liver: 56.7568% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 51.2195% (minimum 75%, Baseline (adaptation disabled)); small intestine: 38.1818% (minimum 75%, Baseline (adaptation disabled))",0.00625,0.0241379,-0.41129,0,80,unavailable,4.1,0.8,1.1,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144488,ESPNL,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.3681% (minimum 95%, Missing); adrenal gland: 96.3235% (minimum 99%, Missing); amygdala: 94.9275% (minimum 99%, Missing); basal ganglia: 94.9275% (minimum 99%, Missing); cerebellum: 73.5955% (minimum 99%, Missing); cerebral cortex: 63.5922% (minimum 99%, Missing); colon: 74.4318% (minimum 97%, Missing); duodenum: 88.5135% (minimum 99%, Missing); esophagus: 81.3665% (minimum 97%, Missing); heart muscle: 84.5161% (minimum 99%, Missing); hippocampal formation: 95.6204% (minimum 99%, Missing); hypothalamus: 93.5714% (minimum 99%, Missing); kidney: 76.6082% (minimum 99%, Missing); liver: 82.3899% (minimum 99%, Missing); lung: 85.0649% (minimum 99%, Missing); lymph node: 92.9078% (minimum 97%, Missing); midbrain: 93.5714% (minimum 99%, Missing); pancreas: 89.7260% (minimum 99%, Missing); parathyroid gland: 37.5358% (minimum 97%, Missing); pituitary gland: 87.3333% (minimum 99%, Missing); rectum: 80.3681% (minimum 97%, Missing); retina: 40.5573% (minimum 99%, Missing); salivary gland: 94.2446% (minimum 97%, Missing); skeletal muscle: 95.6204% (minimum 99%, Missing); skin: 94.9275% (minimum 95%, Missing); small intestine: 77.0588% (minimum 99%, Missing); smooth muscle: 75.2874% (minimum 99%, Missing); spinal cord: 96.3235% (minimum 99%, Missing); spleen: 93.5714% (minimum 95%, Missing); stomach: 78.9157% (minimum 97%, Missing); thymus: 85.6209% (minimum 95%, Missing); thyroid gland: 56.7100% (minimum 95%, Missing); tongue: 77.0588% (minimum 97%, Missing); urinary bladder: 78.9157% (minimum 97%, Missing)",-0.3829,-0.594642,-0.584427,0,80,unavailable,19.2,21.8,10,"parathyroid gland: 21.8 nTPM (protected, limit 2); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); rectum: 3.2 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144619,CNTN4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 73.5955% (minimum 75%, Missing); cerebral cortex: 63.5922% (minimum 75%, Missing); parathyroid gland: 37.5358% (minimum 70%, Missing); retina: 40.5573% (minimum 75%, Missing); thyroid gland: 56.7100% (minimum 65%, Missing)",-0.0829004,-0.324642,-0.344427,0,80,unavailable,19.2,21.8,10,"parathyroid gland: 21.8 nTPM (protected, limit 2); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); rectum: 3.2 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144619,CNTN4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 73.5955% (minimum 75%, Missing); cerebral cortex: 63.5922% (minimum 75%, Missing); parathyroid gland: 37.5358% (minimum 70%, Missing); retina: 40.5573% (minimum 75%, Missing); thyroid gland: 56.7100% (minimum 65%, Missing)",-0.0829004,-0.324642,-0.344427,0,80,unavailable,19.2,21.8,10,"parathyroid gland: 21.8 nTPM (protected, limit 3); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); rectum: 3.2 nTPM (protected, limit 3); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144619,CNTN4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 73.5955% (minimum 75%, Missing); cerebral cortex: 63.5922% (minimum 75%, Missing); parathyroid gland: 37.5358% (minimum 70%, Missing); retina: 40.5573% (minimum 75%, Missing); thyroid gland: 56.7100% (minimum 65%, Missing)",-0.0829004,-0.324642,-0.344427,0,80,unavailable,19.2,21.8,10,"parathyroid gland: 21.8 nTPM (protected, limit 3); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); rectum: 3.2 nTPM (protected, limit 3); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144619,CNTN4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 73.5955% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.5922% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 37.5358% (minimum 70%, Baseline (adaptation disabled)); retina: 40.5573% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 56.7100% (minimum 65%, Baseline (adaptation disabled))",-0.0829004,-0.324642,-0.344427,0,80,unavailable,19.2,21.8,10,"parathyroid gland: 21.8 nTPM (protected, limit 3); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); rectum: 3.2 nTPM (protected, limit 3); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144619,CNTN4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.4138% (minimum 99%, Missing); basal ganglia: 97.4138% (minimum 99%, Missing); bone marrow: 98.2609% (minimum 99%, Missing); cerebellum: 89.6825% (minimum 99%, Missing); cerebral cortex: 92.6230% (minimum 99%, Missing); hippocampal formation: 97.4138% (minimum 99%, Missing); hypothalamus: 97.4138% (minimum 99%, Missing); kidney: 95.7627% (minimum 99%, Missing); midbrain: 98.2609% (minimum 99%, Missing); pituitary gland: 97.4138% (minimum 99%, Missing); skeletal muscle: 97.4138% (minimum 99%, Missing)",0.0412281,0.0126087,-0.0931746,0,80,unavailable,1.3,0.2,0.1,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144671,SLC22A14,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341228,0.282609,0.146825,0,80,unavailable,1.3,0.2,0.1,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144671,SLC22A14,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341228,0.282609,0.146825,0,80,unavailable,1.3,0.2,0.1,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144671,SLC22A14,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341228,0.282609,0.146825,0,80,unavailable,1.3,0.2,0.1,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144671,SLC22A14,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341228,0.282609,0.146825,0,80,unavailable,1.3,0.2,0.1,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144671,SLC22A14,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 82.5000% (minimum 99%, Missing); amygdala: 76.7442% (minimum 99%, Missing); basal ganglia: 76.7442% (minimum 99%, Missing); bone marrow: 80.4878% (minimum 99%, Missing); cerebellum: 58.9286% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 99%, Missing); choroid plexus: 89.1892% (minimum 99%, Missing); colon: 70.2128% (minimum 97%, Missing); duodenum: 97.0588% (minimum 99%, Missing); esophagus: 91.6667% (minimum 97%, Missing); heart muscle: 76.7442% (minimum 99%, Missing); hippocampal formation: 76.7442% (minimum 99%, Missing); hypothalamus: 73.3333% (minimum 99%, Missing); kidney: 76.7442% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 78.5714% (minimum 99%, Missing); lymph node: 78.5714% (minimum 97%, Missing); midbrain: 76.7442% (minimum 99%, Missing); pancreas: 80.4878% (minimum 99%, Missing); parathyroid gland: 82.5000% (minimum 97%, Missing); pituitary gland: 57.8947% (minimum 99%, Missing); rectum: 91.6667% (minimum 97%, Missing); retina: 42.8571% (minimum 99%, Missing); salivary gland: 84.6154% (minimum 97%, Missing); skeletal muscle: 89.1892% (minimum 99%, Missing); skin: 91.6667% (minimum 95%, Missing); small intestine: 78.5714% (minimum 99%, Missing); smooth muscle: 78.5714% (minimum 99%, Missing); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 76.7442% (minimum 95%, Missing); stomach: 80.4878% (minimum 97%, Missing); thymus: 80.4878% (minimum 95%, Missing); thyroid gland: 68.7500% (minimum 95%, Missing); tongue: 89.1892% (minimum 97%, Missing); urinary bladder: 73.3333% (minimum 97%, Missing)",-0.2625,-0.267872,-0.561429,0,80,unavailable,4.4,1.4,1.5,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144792,ZNF660,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 58.9286% (minimum 75%, Missing); hypothalamus: 73.3333% (minimum 75%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); retina: 42.8571% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing)",0.0375,0.00212766,-0.321429,0,80,unavailable,4.4,1.4,1.5,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144792,ZNF660,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 58.9286% (minimum 75%, Missing); hypothalamus: 73.3333% (minimum 75%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); retina: 42.8571% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing)",0.0375,0.00212766,-0.321429,0,80,unavailable,4.4,1.4,1.5,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144792,ZNF660,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 58.9286% (minimum 75%, Missing); hypothalamus: 73.3333% (minimum 75%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); retina: 42.8571% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing)",0.0375,0.00212766,-0.321429,0,80,unavailable,4.4,1.4,1.5,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144792,ZNF660,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 58.9286% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.3333% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 57.8947% (minimum 75%, Baseline (adaptation disabled)); retina: 42.8571% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 75%, Baseline (adaptation disabled))",0.0375,0.00212766,-0.321429,0,80,unavailable,4.4,1.4,1.5,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144792,ZNF660,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Uncertain); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 30.0000% (minimum 99%, Missing); basal ganglia: 33.3333% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 99%, Missing); cerebellum: 50.0000% (minimum 99%, Missing); cerebral cortex: 33.3333% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Uncertain); duodenum: 60.0000% (minimum 99%, Uncertain); heart muscle: 60.0000% (minimum 99%, Missing); hippocampal formation: 30.0000% (minimum 99%, Missing); hypothalamus: 33.3333% (minimum 99%, Missing); lung: 66.6667% (minimum 99%, Missing); lymph node: 85.7143% (minimum 97%, Uncertain); midbrain: 25.0000% (minimum 99%, Missing); pituitary gland: 42.8571% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Uncertain); retina: 16.2162% (minimum 99%, Missing); salivary gland: 85.7143% (minimum 97%, Uncertain); skeletal muscle: 75.0000% (minimum 99%, Missing); skin: 54.5455% (minimum 95%, Missing); small intestine: 50.0000% (minimum 99%, Missing); spinal cord: 26.0870% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Uncertain); stomach: 85.7143% (minimum 97%, Uncertain); thymus: 85.7143% (minimum 95%, Missing); thyroid gland: 85.7143% (minimum 95%, Uncertain); tongue: 23.0769% (minimum 97%, Missing)",-0.404545,-0.739231,-0.827838,0,1,partial,3.1,2,0.5,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144821,MYH15,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 30.0000% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); cerebellum: 50.0000% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Uncertain); duodenum: 60.0000% (minimum 75%, Uncertain); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 30.0000% (minimum 75%, Missing); hypothalamus: 33.3333% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); midbrain: 25.0000% (minimum 75%, Missing); pituitary gland: 42.8571% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Uncertain); retina: 16.2162% (minimum 75%, Missing); skeletal muscle: 75.0000% (minimum 75%, Missing); skin: 54.5455% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); spinal cord: 26.0870% (minimum 75%, Missing); tongue: 23.0769% (minimum 70%, Missing)",-0.104545,-0.469231,-0.587838,0,1,partial,3.1,2,0.5,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144821,MYH15,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 30.0000% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); cerebellum: 50.0000% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Uncertain); duodenum: 60.0000% (minimum 75%, Uncertain); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 30.0000% (minimum 75%, Missing); hypothalamus: 33.3333% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); midbrain: 25.0000% (minimum 75%, Missing); pituitary gland: 42.8571% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Uncertain); retina: 16.2162% (minimum 75%, Missing); skeletal muscle: 75.0000% (minimum 75%, Missing); skin: 54.5455% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); spinal cord: 26.0870% (minimum 75%, Missing); tongue: 23.0769% (minimum 70%, Missing)",-0.104545,-0.469231,-0.587838,0,1,partial,3.1,2,0.5,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144821,MYH15,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 30.0000% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); cerebellum: 50.0000% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Uncertain); duodenum: 60.0000% (minimum 75%, Uncertain); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 30.0000% (minimum 75%, Missing); hypothalamus: 33.3333% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); midbrain: 25.0000% (minimum 75%, Missing); pituitary gland: 42.8571% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Uncertain); retina: 16.2162% (minimum 75%, Missing); skeletal muscle: 75.0000% (minimum 75%, Missing); skin: 54.5455% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); spinal cord: 26.0870% (minimum 75%, Missing); tongue: 23.0769% (minimum 70%, Missing)",-0.104545,-0.469231,-0.587838,0,1,partial,3.1,2,0.5,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144821,MYH15,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); amygdala: 30.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 33.3333% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 50.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 33.3333% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.0000% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 30.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 33.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 66.6667% (minimum 75%, Baseline (adaptation disabled)); midbrain: 25.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 42.8571% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 16.2162% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 54.5455% (minimum 65%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 26.0870% (minimum 75%, Baseline (adaptation disabled)); tongue: 23.0769% (minimum 70%, Baseline (adaptation disabled))",-0.104545,-0.469231,-0.587838,0,1,partial,3.1,2,0.5,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144821,MYH15,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.9735% (minimum 95%, Missing); adrenal gland: 35.2697% (minimum 99%, Uncertain); amygdala: 47.2222% (minimum 99%, Missing); basal ganglia: 44.2708% (minimum 99%, Missing); bone marrow: 61.5942% (minimum 99%, Missing); cerebellum: 49.4186% (minimum 99%, Missing); cerebral cortex: 46.4481% (minimum 99%, Missing); choroid plexus: 62.9630% (minimum 99%, Missing); colon: 51.8293% (minimum 97%, Missing); duodenum: 61.5942% (minimum 99%, Missing); esophagus: 52.4691% (minimum 97%, Missing); heart muscle: 54.8387% (minimum 99%, Missing); hippocampal formation: 49.7076% (minimum 99%, Missing); hypothalamus: 46.4481% (minimum 99%, Missing); kidney: 47.2222% (minimum 99%, Missing); liver: 47.4860% (minimum 99%, Missing); lung: 61.1511% (minimum 99%, Missing); lymph node: 59.4406% (minimum 97%, Uncertain); midbrain: 41.4634% (minimum 99%, Missing); pancreas: 57.8231% (minimum 99%, Missing); parathyroid gland: 42.7136% (minimum 97%, Missing); pituitary gland: 58.2192% (minimum 99%, Missing); rectum: 50.5952% (minimum 97%, Missing); retina: 60.2837% (minimum 99%, Missing); salivary gland: 55.9211% (minimum 97%, Missing); skeletal muscle: 38.9908% (minimum 99%, Missing); skin: 58.2192% (minimum 95%, Missing); small intestine: 59.4406% (minimum 99%, Missing); smooth muscle: 58.6207% (minimum 99%, Missing); spinal cord: 37.9464% (minimum 99%, Missing); spleen: 61.1511% (minimum 95%, Uncertain); stomach: 55.1948% (minimum 97%, Missing); thymus: 57.8231% (minimum 95%, Missing); thyroid gland: 41.6667% (minimum 95%, Missing); tongue: 42.7136% (minimum 97%, Missing); urinary bladder: 54.4872% (minimum 97%, Missing)",-0.533333,-0.542864,-0.637303,0,4,partial,15.6,11.4,11.9,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); tongue: 11.4 nTPM (protected, limit 2); parathyroid gland: 11.4 nTPM (protected, limit 2); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 2); colon: 7.9 nTPM (protected, limit 2); esophagus: 7.7 nTPM (protected, limit 2); urinary bladder: 7.1 nTPM (protected, limit 2); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 2); salivary gland: 6.7 nTPM (protected, limit 2); pancreas: 6.2 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); pituitary gland: 6.1 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); lung: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144840,RABL3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.9735% (minimum 65%, Missing); adrenal gland: 35.2697% (minimum 75%, Uncertain); amygdala: 47.2222% (minimum 75%, Missing); basal ganglia: 44.2708% (minimum 75%, Missing); bone marrow: 61.5942% (minimum 75%, Missing); cerebellum: 49.4186% (minimum 75%, Missing); cerebral cortex: 46.4481% (minimum 75%, Missing); choroid plexus: 62.9630% (minimum 75%, Missing); colon: 51.8293% (minimum 70%, Missing); duodenum: 61.5942% (minimum 75%, Missing); esophagus: 52.4691% (minimum 70%, Missing); heart muscle: 54.8387% (minimum 75%, Missing); hippocampal formation: 49.7076% (minimum 75%, Missing); hypothalamus: 46.4481% (minimum 75%, Missing); kidney: 47.2222% (minimum 75%, Missing); liver: 47.4860% (minimum 75%, Missing); lung: 61.1511% (minimum 75%, Missing); lymph node: 59.4406% (minimum 70%, Uncertain); midbrain: 41.4634% (minimum 75%, Missing); pancreas: 57.8231% (minimum 75%, Missing); parathyroid gland: 42.7136% (minimum 70%, Missing); pituitary gland: 58.2192% (minimum 75%, Missing); rectum: 50.5952% (minimum 70%, Missing); retina: 60.2837% (minimum 75%, Missing); salivary gland: 55.9211% (minimum 70%, Missing); skeletal muscle: 38.9908% (minimum 75%, Missing); skin: 58.2192% (minimum 65%, Missing); small intestine: 59.4406% (minimum 75%, Missing); smooth muscle: 58.6207% (minimum 75%, Missing); spinal cord: 37.9464% (minimum 75%, Missing); spleen: 61.1511% (minimum 65%, Uncertain); stomach: 55.1948% (minimum 70%, Missing); thymus: 57.8231% (minimum 65%, Missing); thyroid gland: 41.6667% (minimum 65%, Missing); tongue: 42.7136% (minimum 70%, Missing); urinary bladder: 54.4872% (minimum 70%, Missing)",-0.233333,-0.272864,-0.397303,0,4,partial,15.6,11.4,11.9,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); tongue: 11.4 nTPM (protected, limit 2); parathyroid gland: 11.4 nTPM (protected, limit 2); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 2); colon: 7.9 nTPM (protected, limit 2); esophagus: 7.7 nTPM (protected, limit 2); urinary bladder: 7.1 nTPM (protected, limit 2); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 2); salivary gland: 6.7 nTPM (protected, limit 2); pancreas: 6.2 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); pituitary gland: 6.1 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); lung: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144840,RABL3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.9735% (minimum 65%, Missing); adrenal gland: 35.2697% (minimum 75%, Uncertain); amygdala: 47.2222% (minimum 75%, Missing); basal ganglia: 44.2708% (minimum 75%, Missing); bone marrow: 61.5942% (minimum 75%, Missing); cerebellum: 49.4186% (minimum 75%, Missing); cerebral cortex: 46.4481% (minimum 75%, Missing); choroid plexus: 62.9630% (minimum 75%, Missing); colon: 51.8293% (minimum 70%, Missing); duodenum: 61.5942% (minimum 75%, Missing); esophagus: 52.4691% (minimum 70%, Missing); heart muscle: 54.8387% (minimum 75%, Missing); hippocampal formation: 49.7076% (minimum 75%, Missing); hypothalamus: 46.4481% (minimum 75%, Missing); kidney: 47.2222% (minimum 75%, Missing); liver: 47.4860% (minimum 75%, Missing); lung: 61.1511% (minimum 75%, Missing); lymph node: 59.4406% (minimum 70%, Uncertain); midbrain: 41.4634% (minimum 75%, Missing); pancreas: 57.8231% (minimum 75%, Missing); parathyroid gland: 42.7136% (minimum 70%, Missing); pituitary gland: 58.2192% (minimum 75%, Missing); rectum: 50.5952% (minimum 70%, Missing); retina: 60.2837% (minimum 75%, Missing); salivary gland: 55.9211% (minimum 70%, Missing); skeletal muscle: 38.9908% (minimum 75%, Missing); skin: 58.2192% (minimum 65%, Missing); small intestine: 59.4406% (minimum 75%, Missing); smooth muscle: 58.6207% (minimum 75%, Missing); spinal cord: 37.9464% (minimum 75%, Missing); spleen: 61.1511% (minimum 65%, Uncertain); stomach: 55.1948% (minimum 70%, Missing); thymus: 57.8231% (minimum 65%, Missing); thyroid gland: 41.6667% (minimum 65%, Missing); tongue: 42.7136% (minimum 70%, Missing); urinary bladder: 54.4872% (minimum 70%, Missing)",-0.233333,-0.272864,-0.397303,0,4,partial,15.6,11.4,11.9,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); tongue: 11.4 nTPM (protected, limit 3); parathyroid gland: 11.4 nTPM (protected, limit 3); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 3); colon: 7.9 nTPM (protected, limit 3); esophagus: 7.7 nTPM (protected, limit 3); urinary bladder: 7.1 nTPM (protected, limit 3); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 3); salivary gland: 6.7 nTPM (protected, limit 3); pancreas: 6.2 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); pituitary gland: 6.1 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); lung: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144840,RABL3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.9735% (minimum 65%, Missing); adrenal gland: 35.2697% (minimum 75%, Uncertain); amygdala: 47.2222% (minimum 75%, Missing); basal ganglia: 44.2708% (minimum 75%, Missing); bone marrow: 61.5942% (minimum 75%, Missing); cerebellum: 49.4186% (minimum 75%, Missing); cerebral cortex: 46.4481% (minimum 75%, Missing); choroid plexus: 62.9630% (minimum 75%, Missing); colon: 51.8293% (minimum 70%, Missing); duodenum: 61.5942% (minimum 75%, Missing); esophagus: 52.4691% (minimum 70%, Missing); heart muscle: 54.8387% (minimum 75%, Missing); hippocampal formation: 49.7076% (minimum 75%, Missing); hypothalamus: 46.4481% (minimum 75%, Missing); kidney: 47.2222% (minimum 75%, Missing); liver: 47.4860% (minimum 75%, Missing); lung: 61.1511% (minimum 75%, Missing); lymph node: 59.4406% (minimum 70%, Uncertain); midbrain: 41.4634% (minimum 75%, Missing); pancreas: 57.8231% (minimum 75%, Missing); parathyroid gland: 42.7136% (minimum 70%, Missing); pituitary gland: 58.2192% (minimum 75%, Missing); rectum: 50.5952% (minimum 70%, Missing); retina: 60.2837% (minimum 75%, Missing); salivary gland: 55.9211% (minimum 70%, Missing); skeletal muscle: 38.9908% (minimum 75%, Missing); skin: 58.2192% (minimum 65%, Missing); small intestine: 59.4406% (minimum 75%, Missing); smooth muscle: 58.6207% (minimum 75%, Missing); spinal cord: 37.9464% (minimum 75%, Missing); spleen: 61.1511% (minimum 65%, Uncertain); stomach: 55.1948% (minimum 70%, Missing); thymus: 57.8231% (minimum 65%, Missing); thyroid gland: 41.6667% (minimum 65%, Missing); tongue: 42.7136% (minimum 70%, Missing); urinary bladder: 54.4872% (minimum 70%, Missing)",-0.233333,-0.272864,-0.397303,0,4,partial,15.6,11.4,11.9,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); tongue: 11.4 nTPM (protected, limit 3); parathyroid gland: 11.4 nTPM (protected, limit 3); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 3); colon: 7.9 nTPM (protected, limit 3); esophagus: 7.7 nTPM (protected, limit 3); urinary bladder: 7.1 nTPM (protected, limit 3); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 3); salivary gland: 6.7 nTPM (protected, limit 3); pancreas: 6.2 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); pituitary gland: 6.1 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); lung: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144840,RABL3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.9735% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 35.2697% (minimum 75%, Baseline (adaptation disabled)); amygdala: 47.2222% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 44.2708% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.5942% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 49.4186% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 46.4481% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 62.9630% (minimum 75%, Baseline (adaptation disabled)); colon: 51.8293% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.5942% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.4691% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 54.8387% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 49.7076% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 46.4481% (minimum 75%, Baseline (adaptation disabled)); kidney: 47.2222% (minimum 75%, Baseline (adaptation disabled)); liver: 47.4860% (minimum 75%, Baseline (adaptation disabled)); lung: 61.1511% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.4406% (minimum 70%, Baseline (adaptation disabled)); midbrain: 41.4634% (minimum 75%, Baseline (adaptation disabled)); pancreas: 57.8231% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 42.7136% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.2192% (minimum 75%, Baseline (adaptation disabled)); rectum: 50.5952% (minimum 70%, Baseline (adaptation disabled)); retina: 60.2837% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.9211% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 38.9908% (minimum 75%, Baseline (adaptation disabled)); skin: 58.2192% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.4406% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.6207% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 37.9464% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.1511% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.1948% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.8231% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 41.6667% (minimum 65%, Baseline (adaptation disabled)); tongue: 42.7136% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 54.4872% (minimum 70%, Baseline (adaptation disabled))",-0.233333,-0.272864,-0.397303,0,4,partial,15.6,11.4,11.9,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); tongue: 11.4 nTPM (protected, limit 3); parathyroid gland: 11.4 nTPM (protected, limit 3); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 3); colon: 7.9 nTPM (protected, limit 3); esophagus: 7.7 nTPM (protected, limit 3); urinary bladder: 7.1 nTPM (protected, limit 3); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 3); salivary gland: 6.7 nTPM (protected, limit 3); pancreas: 6.2 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); pituitary gland: 6.1 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); lung: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144840,RABL3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.1754% (minimum 99%, Missing); amygdala: 55.5556% (minimum 99%, Missing); basal ganglia: 58.8235% (minimum 99%, Missing); bone marrow: 51.2821% (minimum 95%, Enhanced); cerebellum: 61.5385% (minimum 99%, Missing); cerebral cortex: 52.6316% (minimum 99%, Missing); choroid plexus: 59.7015% (minimum 99%, Missing); colon: 95.2381% (minimum 97%, Missing); duodenum: 83.3333% (minimum 99%, Missing); heart muscle: 93.0233% (minimum 95%, Enhanced); hippocampal formation: 61.5385% (minimum 99%, Missing); hypothalamus: 61.5385% (minimum 99%, Missing); lung: 95.2381% (minimum 99%, Missing); midbrain: 57.1429% (minimum 99%, Missing); pancreas: 97.5610% (minimum 99%, Missing); pituitary gland: 71.4286% (minimum 99%, Missing); retina: 59.7015% (minimum 99%, Missing); skeletal muscle: 93.0233% (minimum 95%, Enhanced); small intestine: 93.0233% (minimum 95%, Enhanced); smooth muscle: 93.0233% (minimum 99%, Missing); spinal cord: 61.5385% (minimum 99%, Missing); thymus: 90.9091% (minimum 95%, Missing)",-0.0409091,-0.017619,-0.463684,0,1,partial,3.8,1,0.7,"cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144893,MED12L,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.1754% (minimum 75%, Missing); amygdala: 55.5556% (minimum 75%, Missing); basal ganglia: 58.8235% (minimum 75%, Missing); bone marrow: 51.2821% (minimum 60%, Enhanced); cerebellum: 61.5385% (minimum 75%, Missing); cerebral cortex: 52.6316% (minimum 75%, Missing); choroid plexus: 59.7015% (minimum 75%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); midbrain: 57.1429% (minimum 75%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 59.7015% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing)",0.259091,0.25,-0.223684,0,1,partial,3.8,1,0.7,"cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144893,MED12L,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.1754% (minimum 75%, Missing); amygdala: 55.5556% (minimum 75%, Missing); basal ganglia: 58.8235% (minimum 75%, Missing); bone marrow: 51.2821% (minimum 60%, Enhanced); cerebellum: 61.5385% (minimum 75%, Missing); cerebral cortex: 52.6316% (minimum 75%, Missing); choroid plexus: 59.7015% (minimum 75%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); midbrain: 57.1429% (minimum 75%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 59.7015% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing)",0.259091,0.25,-0.223684,0,1,partial,3.8,1,0.7,"cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144893,MED12L,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.1754% (minimum 75%, Missing); amygdala: 55.5556% (minimum 75%, Missing); basal ganglia: 58.8235% (minimum 75%, Missing); bone marrow: 51.2821% (minimum 60%, Enhanced); cerebellum: 61.5385% (minimum 75%, Missing); cerebral cortex: 52.6316% (minimum 75%, Missing); choroid plexus: 59.7015% (minimum 75%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); midbrain: 57.1429% (minimum 75%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 59.7015% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing)",0.259091,0.25,-0.223684,0,1,partial,3.8,1,0.7,"cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144893,MED12L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.1754% (minimum 75%, Baseline (adaptation disabled)); amygdala: 55.5556% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.8235% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 51.2821% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.5385% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 52.6316% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 59.7015% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.5385% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.5385% (minimum 75%, Baseline (adaptation disabled)); midbrain: 57.1429% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 71.4286% (minimum 75%, Baseline (adaptation disabled)); retina: 59.7015% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.5385% (minimum 75%, Baseline (adaptation disabled))",0.201064,0.1,-0.237179,0,1,partial,3.8,1,0.7,"bone marrow: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144893,MED12L,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144962,SPATA16,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144962,SPATA16,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144962,SPATA16,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144962,SPATA16,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000144962,SPATA16,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7273% (minimum 99%, Missing); basal ganglia: 95.5556% (minimum 99%, Missing); bone marrow: 97.7273% (minimum 99%, Missing); cerebellum: 91.4894% (minimum 99%, Missing); cerebral cortex: 97.7273% (minimum 99%, Missing); choroid plexus: 97.7273% (minimum 99%, Missing); colon: 95.5556% (minimum 97%, Missing); duodenum: 97.7273% (minimum 99%, Missing); esophagus: 56.5789% (minimum 97%, Missing); heart muscle: 93.4783% (minimum 99%, Missing); hippocampal formation: 97.7273% (minimum 99%, Missing); hypothalamus: 89.5833% (minimum 99%, Missing); kidney: 75.4386% (minimum 99%, Missing); lung: 95.5556% (minimum 99%, Missing); midbrain: 97.7273% (minimum 99%, Missing); pituitary gland: 93.4783% (minimum 99%, Missing); salivary gland: 72.8814% (minimum 97%, Missing); skeletal muscle: 95.5556% (minimum 99%, Missing); skin: 25.1462% (minimum 95%, Missing); small intestine: 95.5556% (minimum 99%, Missing); smooth muscle: 95.5556% (minimum 99%, Missing); spinal cord: 97.7273% (minimum 99%, Missing); spleen: 87.7551% (minimum 95%, Missing); urinary bladder: 89.5833% (minimum 97%, Missing)",-0.698538,-0.404211,-0.235614,0,80,unavailable,1.4,3.3,12.8,"skin: 12.8 nTPM (manageable, limit 5); esophagus: 3.3 nTPM (protected, limit 2); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145040,UCN2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 56.5789% (minimum 70%, Missing); skin: 25.1462% (minimum 65%, Missing)",-0.398538,-0.134211,0.00438596,0,80,unavailable,1.4,3.3,12.8,"skin: 12.8 nTPM (manageable, limit 5); esophagus: 3.3 nTPM (protected, limit 2); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145040,UCN2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 56.5789% (minimum 70%, Missing); skin: 25.1462% (minimum 65%, Missing)",-0.398538,-0.134211,0.00438596,0,80,unavailable,1.4,3.3,12.8,"skin: 12.8 nTPM (manageable, limit 5); esophagus: 3.3 nTPM (protected, limit 3); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145040,UCN2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 56.5789% (minimum 70%, Missing); skin: 25.1462% (minimum 65%, Missing)",-0.398538,-0.134211,0.00438596,0,80,unavailable,1.4,3.3,12.8,"skin: 12.8 nTPM (manageable, limit 5); esophagus: 3.3 nTPM (protected, limit 3); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145040,UCN2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 56.5789% (minimum 70%, Baseline (adaptation disabled)); skin: 25.1462% (minimum 65%, Baseline (adaptation disabled))",-0.398538,-0.134211,0.00438596,0,80,unavailable,1.4,3.3,12.8,"skin: 12.8 nTPM (manageable, limit 5); esophagus: 3.3 nTPM (protected, limit 3); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145040,UCN2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.4490% (minimum 95%, Missing); adrenal gland: 66.8122% (minimum 99%, Missing); amygdala: 73.5577% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 52.3973% (minimum 99%, Missing); cerebellum: 70.6697% (minimum 99%, Missing); cerebral cortex: 69.7039% (minimum 99%, Missing); choroid plexus: 81.1671% (minimum 99%, Missing); colon: 68.7640% (minimum 97%, Missing); duodenum: 73.5577% (minimum 99%, Missing); esophagus: 66.5217% (minimum 97%, Missing); heart muscle: 70.9977% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 75.1843% (minimum 99%, Missing); kidney: 70.3448% (minimum 99%, Missing); liver: 70.1835% (minimum 99%, Missing); lung: 68.9189% (minimum 99%, Missing); lymph node: 61.8182% (minimum 97%, Missing); midbrain: 74.6341% (minimum 99%, Missing); pancreas: 75.9305% (minimum 99%, Missing); parathyroid gland: 64.6934% (minimum 90%, Supported); pituitary gland: 76.5000% (minimum 99%, Missing); rectum: 68.1514% (minimum 97%, Missing); retina: 65.2452% (minimum 99%, Missing); salivary gland: 68.3036% (minimum 90%, Supported); skeletal muscle: 55.1351% (minimum 99%, Missing); skin: 63.8831% (minimum 95%, Missing); small intestine: 68.6099% (minimum 99%, Missing); smooth muscle: 67.4009% (minimum 99%, Missing); spinal cord: 71.1628% (minimum 99%, Missing); spleen: 69.0745% (minimum 80%, Supported); stomach: 69.5455% (minimum 97%, Missing); thymus: 51.4286% (minimum 95%, Missing); thyroid gland: 67.2527% (minimum 95%, Missing); tongue: 72.0000% (minimum 97%, Missing); urinary bladder: 64.4211% (minimum 97%, Missing)",-0.435714,-0.351818,-0.466027,0,7,partial,27.8,18.9,28.9,"thymus: 28.9 nTPM (manageable, limit 5); bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 2); adipose tissue: 18.4 nTPM (manageable, limit 5); skin: 17.3 nTPM (manageable, limit 5); urinary bladder: 16.9 nTPM (protected, limit 2); parathyroid gland: 16.7 nTPM (protected, limit 6); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 2); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (manageable, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 2); salivary gland: 14.2 nTPM (protected, limit 6); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 2); lung: 13.8 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 2); duodenum: 11 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145216,FIP1L1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.4490% (minimum 65%, Missing); adrenal gland: 66.8122% (minimum 75%, Missing); amygdala: 73.5577% (minimum 75%, Missing); bone marrow: 52.3973% (minimum 75%, Missing); cerebellum: 70.6697% (minimum 75%, Missing); cerebral cortex: 69.7039% (minimum 75%, Missing); colon: 68.7640% (minimum 70%, Missing); duodenum: 73.5577% (minimum 75%, Missing); esophagus: 66.5217% (minimum 70%, Missing); heart muscle: 70.9977% (minimum 75%, Missing); kidney: 70.3448% (minimum 75%, Missing); liver: 70.1835% (minimum 75%, Missing); lung: 68.9189% (minimum 75%, Missing); lymph node: 61.8182% (minimum 70%, Missing); midbrain: 74.6341% (minimum 75%, Missing); rectum: 68.1514% (minimum 70%, Missing); retina: 65.2452% (minimum 75%, Missing); skeletal muscle: 55.1351% (minimum 75%, Missing); skin: 63.8831% (minimum 65%, Missing); small intestine: 68.6099% (minimum 75%, Missing); smooth muscle: 67.4009% (minimum 75%, Missing); spinal cord: 71.1628% (minimum 75%, Missing); stomach: 69.5455% (minimum 70%, Missing); thymus: 51.4286% (minimum 65%, Missing); urinary bladder: 64.4211% (minimum 70%, Missing)",-0.135714,-0.0818182,-0.226027,0,7,partial,27.8,18.9,28.9,"thymus: 28.9 nTPM (manageable, limit 5); bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 2); adipose tissue: 18.4 nTPM (manageable, limit 5); skin: 17.3 nTPM (manageable, limit 5); urinary bladder: 16.9 nTPM (protected, limit 2); parathyroid gland: 16.7 nTPM (protected, limit 6); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 2); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (manageable, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 2); salivary gland: 14.2 nTPM (protected, limit 6); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 2); lung: 13.8 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 2); duodenum: 11 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145216,FIP1L1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.4490% (minimum 65%, Missing); adrenal gland: 66.8122% (minimum 75%, Missing); amygdala: 73.5577% (minimum 75%, Missing); bone marrow: 52.3973% (minimum 75%, Missing); cerebellum: 70.6697% (minimum 75%, Missing); cerebral cortex: 69.7039% (minimum 75%, Missing); colon: 68.7640% (minimum 70%, Missing); duodenum: 73.5577% (minimum 75%, Missing); esophagus: 66.5217% (minimum 70%, Missing); heart muscle: 70.9977% (minimum 75%, Missing); kidney: 70.3448% (minimum 75%, Missing); liver: 70.1835% (minimum 75%, Missing); lung: 68.9189% (minimum 75%, Missing); lymph node: 61.8182% (minimum 70%, Missing); midbrain: 74.6341% (minimum 75%, Missing); rectum: 68.1514% (minimum 70%, Missing); retina: 65.2452% (minimum 75%, Missing); skeletal muscle: 55.1351% (minimum 75%, Missing); skin: 63.8831% (minimum 65%, Missing); small intestine: 68.6099% (minimum 75%, Missing); smooth muscle: 67.4009% (minimum 75%, Missing); spinal cord: 71.1628% (minimum 75%, Missing); stomach: 69.5455% (minimum 70%, Missing); thymus: 51.4286% (minimum 65%, Missing); urinary bladder: 64.4211% (minimum 70%, Missing)",-0.135714,-0.0818182,-0.226027,0,7,partial,27.8,18.9,28.9,"thymus: 28.9 nTPM (manageable, limit 5); bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 3); adipose tissue: 18.4 nTPM (manageable, limit 5); skin: 17.3 nTPM (manageable, limit 5); urinary bladder: 16.9 nTPM (protected, limit 3); parathyroid gland: 16.7 nTPM (protected, limit 6); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 3); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (manageable, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 3); salivary gland: 14.2 nTPM (protected, limit 6); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 3); lung: 13.8 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 3); duodenum: 11 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145216,FIP1L1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.4490% (minimum 65%, Missing); adrenal gland: 66.8122% (minimum 75%, Missing); amygdala: 73.5577% (minimum 75%, Missing); bone marrow: 52.3973% (minimum 75%, Missing); cerebellum: 70.6697% (minimum 75%, Missing); cerebral cortex: 69.7039% (minimum 75%, Missing); colon: 68.7640% (minimum 70%, Missing); duodenum: 73.5577% (minimum 75%, Missing); esophagus: 66.5217% (minimum 70%, Missing); heart muscle: 70.9977% (minimum 75%, Missing); kidney: 70.3448% (minimum 75%, Missing); liver: 70.1835% (minimum 75%, Missing); lung: 68.9189% (minimum 75%, Missing); lymph node: 61.8182% (minimum 70%, Missing); midbrain: 74.6341% (minimum 75%, Missing); rectum: 68.1514% (minimum 70%, Missing); retina: 65.2452% (minimum 75%, Missing); skeletal muscle: 55.1351% (minimum 75%, Missing); skin: 63.8831% (minimum 65%, Missing); small intestine: 68.6099% (minimum 75%, Missing); smooth muscle: 67.4009% (minimum 75%, Missing); spinal cord: 71.1628% (minimum 75%, Missing); stomach: 69.5455% (minimum 70%, Missing); thymus: 51.4286% (minimum 65%, Missing); urinary bladder: 64.4211% (minimum 70%, Missing)",-0.135714,-0.0818182,-0.226027,0,7,partial,27.8,18.9,28.9,"thymus: 28.9 nTPM (manageable, limit 5); bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 3); adipose tissue: 18.4 nTPM (manageable, limit 5); skin: 17.3 nTPM (manageable, limit 5); urinary bladder: 16.9 nTPM (protected, limit 3); parathyroid gland: 16.7 nTPM (protected, limit 6); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 3); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (manageable, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 3); salivary gland: 14.2 nTPM (protected, limit 6); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 3); lung: 13.8 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 3); duodenum: 11 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145216,FIP1L1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.4490% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 66.8122% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.5577% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 52.3973% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.6697% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 69.7039% (minimum 75%, Baseline (adaptation disabled)); colon: 68.7640% (minimum 70%, Baseline (adaptation disabled)); duodenum: 73.5577% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.5217% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.9977% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.3448% (minimum 75%, Baseline (adaptation disabled)); liver: 70.1835% (minimum 75%, Baseline (adaptation disabled)); lung: 68.9189% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.8182% (minimum 70%, Baseline (adaptation disabled)); midbrain: 74.6341% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.6934% (minimum 70%, Baseline (adaptation disabled)); rectum: 68.1514% (minimum 70%, Baseline (adaptation disabled)); retina: 65.2452% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.3036% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.1351% (minimum 75%, Baseline (adaptation disabled)); skin: 63.8831% (minimum 65%, Baseline (adaptation disabled)); small intestine: 68.6099% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.4009% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.1628% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.5455% (minimum 70%, Baseline (adaptation disabled)); thymus: 51.4286% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 64.4211% (minimum 70%, Baseline (adaptation disabled))",-0.135714,-0.0818182,-0.226027,0,7,partial,27.8,18.9,28.9,"thymus: 28.9 nTPM (manageable, limit 5); bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 3); adipose tissue: 18.4 nTPM (manageable, limit 5); skin: 17.3 nTPM (manageable, limit 5); urinary bladder: 16.9 nTPM (protected, limit 3); parathyroid gland: 16.7 nTPM (protected, limit 3); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 3); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (manageable, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 3); salivary gland: 14.2 nTPM (protected, limit 3); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 3); lung: 13.8 nTPM (vital, limit 1); spleen: 13.7 nTPM (manageable, limit 5); stomach: 13.4 nTPM (protected, limit 3); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 3); amygdala: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145216,FIP1L1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,3.9,0,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145309,CABS1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,3.9,0,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145309,CABS1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,3.9,0,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145309,CABS1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,3.9,0,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145309,CABS1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.263653,0.25,0,1,partial,0,3.9,0,"salivary gland: 3.9 nTPM (protected, limit 3)",,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145309,CABS1,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.0730% (minimum 95%, Missing); adrenal gland: 72.7273% (minimum 99%, Missing); amygdala: 81.3559% (minimum 99%, Missing); basal ganglia: 78.6885% (minimum 99%, Missing); bone marrow: 81.3559% (minimum 99%, Missing); cerebellum: 86.4865% (minimum 99%, Missing); cerebral cortex: 75.5906% (minimum 99%, Missing); choroid plexus: 91.4286% (minimum 99%, Missing); colon: 73.2824% (minimum 97%, Missing); duodenum: 69.5652% (minimum 99%, Missing); esophagus: 73.2824% (minimum 97%, Missing); heart muscle: 81.3559% (minimum 99%, Missing); hippocampal formation: 80.6723% (minimum 99%, Missing); hypothalamus: 80.6723% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 50.2618% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 69.0647% (minimum 97%, Missing); midbrain: 77.4194% (minimum 99%, Missing); pancreas: 62.7451% (minimum 99%, Missing); parathyroid gland: 72.7273% (minimum 97%, Missing); pituitary gland: 80.6723% (minimum 99%, Missing); rectum: 73.2824% (minimum 97%, Missing); retina: 78.0488% (minimum 99%, Missing); salivary gland: 71.6418% (minimum 97%, Missing); skeletal muscle: 71.6418% (minimum 99%, Missing); skin: 72.7273% (minimum 95%, Missing); small intestine: 68.5714% (minimum 99%, Missing); smooth muscle: 78.6885% (minimum 99%, Missing); spinal cord: 71.6418% (minimum 99%, Missing); spleen: 73.8462% (minimum 95%, Missing); stomach: 69.0647% (minimum 97%, Missing); thymus: 69.5652% (minimum 95%, Missing); thyroid gland: 61.9355% (minimum 95%, Missing); tongue: 78.6885% (minimum 97%, Missing); urinary bladder: 77.4194% (minimum 97%, Missing)",-0.330645,-0.279353,-0.487382,0,80,unavailable,9.5,4.3,5.9,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 2); stomach: 4.3 nTPM (protected, limit 2); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145331,TRMT10A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.7273% (minimum 75%, Missing); duodenum: 69.5652% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 50.2618% (minimum 75%, Missing); lymph node: 69.0647% (minimum 70%, Missing); pancreas: 62.7451% (minimum 75%, Missing); skeletal muscle: 71.6418% (minimum 75%, Missing); small intestine: 68.5714% (minimum 75%, Missing); spinal cord: 71.6418% (minimum 75%, Missing); stomach: 69.0647% (minimum 70%, Missing); thyroid gland: 61.9355% (minimum 65%, Missing)",-0.0306452,-0.00935252,-0.247382,0,80,unavailable,9.5,4.3,5.9,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 2); stomach: 4.3 nTPM (protected, limit 2); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145331,TRMT10A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.7273% (minimum 75%, Missing); duodenum: 69.5652% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 50.2618% (minimum 75%, Missing); lymph node: 69.0647% (minimum 70%, Missing); pancreas: 62.7451% (minimum 75%, Missing); skeletal muscle: 71.6418% (minimum 75%, Missing); small intestine: 68.5714% (minimum 75%, Missing); spinal cord: 71.6418% (minimum 75%, Missing); stomach: 69.0647% (minimum 70%, Missing); thyroid gland: 61.9355% (minimum 65%, Missing)",-0.0306452,-0.00935252,-0.247382,0,80,unavailable,9.5,4.3,5.9,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 3); lymph node: 4.3 nTPM (protected, limit 3); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145331,TRMT10A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.7273% (minimum 75%, Missing); duodenum: 69.5652% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 50.2618% (minimum 75%, Missing); lymph node: 69.0647% (minimum 70%, Missing); pancreas: 62.7451% (minimum 75%, Missing); skeletal muscle: 71.6418% (minimum 75%, Missing); small intestine: 68.5714% (minimum 75%, Missing); spinal cord: 71.6418% (minimum 75%, Missing); stomach: 69.0647% (minimum 70%, Missing); thyroid gland: 61.9355% (minimum 65%, Missing)",-0.0306452,-0.00935252,-0.247382,0,80,unavailable,9.5,4.3,5.9,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 3); lymph node: 4.3 nTPM (protected, limit 3); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145331,TRMT10A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.7273% (minimum 75%, Baseline (adaptation disabled)); duodenum: 69.5652% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 50.2618% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.0647% (minimum 70%, Baseline (adaptation disabled)); pancreas: 62.7451% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 71.6418% (minimum 75%, Baseline (adaptation disabled)); small intestine: 68.5714% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.6418% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.0647% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 61.9355% (minimum 65%, Baseline (adaptation disabled))",-0.0306452,-0.00935252,-0.247382,0,80,unavailable,9.5,4.3,5.9,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 3); lymph node: 4.3 nTPM (protected, limit 3); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145331,TRMT10A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.9167% (minimum 90%, Approved); adrenal gland: 81.3953% (minimum 99%, Missing); amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 71.4286% (minimum 99%, Missing); cerebellum: 81.3953% (minimum 99%, Missing); cerebral cortex: 81.3953% (minimum 99%, Missing); choroid plexus: 85.3659% (minimum 99%, Missing); colon: 77.7778% (minimum 97%, Missing); duodenum: 83.3333% (minimum 99%, Missing); esophagus: 77.7778% (minimum 97%, Missing); heart muscle: 81.3953% (minimum 99%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing); hypothalamus: 85.3659% (minimum 99%, Missing); kidney: 76.0870% (minimum 99%, Missing); liver: 76.0870% (minimum 99%, Missing); lung: 79.5455% (minimum 99%, Missing); lymph node: 74.4681% (minimum 97%, Missing); midbrain: 85.3659% (minimum 99%, Missing); pancreas: 81.3953% (minimum 99%, Missing); parathyroid gland: 70.0000% (minimum 97%, Missing); pituitary gland: 83.3333% (minimum 99%, Missing); rectum: 74.4681% (minimum 97%, Missing); retina: 61.4035% (minimum 99%, Missing); salivary gland: 76.0870% (minimum 97%, Missing); skeletal muscle: 72.9167% (minimum 98%, Approved); skin: 74.4681% (minimum 95%, Missing); small intestine: 83.3333% (minimum 99%, Missing); smooth muscle: 74.4681% (minimum 98%, Approved); spinal cord: 83.3333% (minimum 99%, Missing); spleen: 74.4681% (minimum 95%, Missing); stomach: 60.3448% (minimum 97%, Missing); thymus: 63.6364% (minimum 95%, Missing); thyroid gland: 70.0000% (minimum 95%, Missing); tongue: 74.4681% (minimum 97%, Missing); urinary bladder: 77.7778% (minimum 97%, Missing)",-0.313636,-0.366552,-0.375965,0,0,routine_complete,2.2,2.3,2,"stomach: 2.3 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145375,AFG2A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); retina: 61.4035% (minimum 75%, Missing); stomach: 60.3448% (minimum 70%, Missing); thymus: 63.6364% (minimum 65%, Missing)",-0.0136364,-0.0965517,-0.135965,0,0,routine_complete,2.2,2.3,2,"stomach: 2.3 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145375,AFG2A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); retina: 61.4035% (minimum 75%, Missing); stomach: 60.3448% (minimum 70%, Missing); thymus: 63.6364% (minimum 65%, Missing)",-0.0136364,-0.0965517,-0.135965,0,0,routine_complete,2.2,2.3,2,"retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145375,AFG2A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); retina: 61.4035% (minimum 75%, Missing); stomach: 60.3448% (minimum 70%, Missing); thymus: 63.6364% (minimum 65%, Missing)",-0.0136364,-0.0965517,-0.135965,0,0,routine_complete,2.2,2.3,2,"retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145375,AFG2A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 71.4286% (minimum 75%, Baseline (adaptation disabled)); retina: 61.4035% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 72.9167% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 74.4681% (minimum 75%, Baseline (adaptation disabled)); stomach: 60.3448% (minimum 70%, Baseline (adaptation disabled)); thymus: 63.6364% (minimum 65%, Baseline (adaptation disabled))",-0.0136364,-0.0965517,-0.135965,0,0,routine_complete,2.2,2.3,2,"retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145375,AFG2A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.9288% (minimum 99%, Missing); basal ganglia: 98.7421% (minimum 99%, Missing); choroid plexus: 96.6154% (minimum 99%, Missing); hippocampal formation: 98.2171% (minimum 99%, Missing); hypothalamus: 98.5562% (minimum 99%, Missing)",0.0493635,0.0290455,-0.0238462,0,4,partial,11,0.4,4.3,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145491,ROPN1L,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349363,0.299045,0.216154,0,4,partial,11,0.4,4.3,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145491,ROPN1L,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349363,0.299045,0.216154,0,4,partial,11,0.4,4.3,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145491,ROPN1L,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349363,0.299045,0.216154,0,4,partial,11,0.4,4.3,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145491,ROPN1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.336491,0.298728,0.216154,0,4,partial,11,0.4,4.3,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145491,ROPN1L,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.1538% (minimum 95%, Missing); adrenal gland: 50.0000% (minimum 99%, Missing); amygdala: 93.5780% (minimum 99%, Missing); basal ganglia: 91.8919% (minimum 99%, Missing); bone marrow: 68.9189% (minimum 99%, Missing); cerebellum: 89.4737% (minimum 99%, Missing); cerebral cortex: 37.7778% (minimum 99%, Missing); choroid plexus: 76.6917% (minimum 99%, Missing); colon: 57.3034% (minimum 97%, Missing); duodenum: 56.0440% (minimum 99%, Missing); esophagus: 53.9683% (minimum 97%, Missing); heart muscle: 34.0000% (minimum 99%, Missing); hippocampal formation: 94.4444% (minimum 99%, Missing); hypothalamus: 91.8919% (minimum 99%, Missing); kidney: 44.7368% (minimum 99%, Missing); liver: 49.0385% (minimum 99%, Uncertain); lung: 60.7143% (minimum 99%, Missing); lymph node: 61.4458% (minimum 97%, Uncertain); midbrain: 94.4444% (minimum 99%, Missing); pancreas: 57.9545% (minimum 99%, Missing); parathyroid gland: 34.9315% (minimum 97%, Uncertain); pituitary gland: 92.7273% (minimum 99%, Missing); rectum: 56.9832% (minimum 97%, Missing); retina: 35.0515% (minimum 99%, Missing); salivary gland: 57.9545% (minimum 97%, Missing); skeletal muscle: 19.5402% (minimum 99%, Missing); skin: 60.7143% (minimum 95%, Missing); small intestine: 55.7377% (minimum 99%, Missing); smooth muscle: 54.5455% (minimum 99%, Missing); spinal cord: 93.5780% (minimum 99%, Missing); spleen: 55.4348% (minimum 95%, Missing); stomach: 56.9832% (minimum 97%, Uncertain); thymus: 57.9545% (minimum 95%, Missing); thyroid gland: 36.0424% (minimum 95%, Uncertain); tongue: 25.0614% (minimum 97%, Missing); urinary bladder: 62.1951% (minimum 97%, Missing)",-0.589576,-0.719386,-0.794598,0,6,partial,42,30.5,18.1,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 2); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 2); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); smooth muscle: 8.5 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); rectum: 7.7 nTPM (protected, limit 2); colon: 7.6 nTPM (protected, limit 2); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.4 nTPM (vital, limit 1); salivary gland: 7.4 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145743,FBXL17,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.1538% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); bone marrow: 68.9189% (minimum 75%, Missing); cerebral cortex: 37.7778% (minimum 75%, Missing); colon: 57.3034% (minimum 70%, Missing); duodenum: 56.0440% (minimum 75%, Missing); esophagus: 53.9683% (minimum 70%, Missing); heart muscle: 34.0000% (minimum 75%, Missing); kidney: 44.7368% (minimum 75%, Missing); liver: 49.0385% (minimum 75%, Uncertain); lung: 60.7143% (minimum 75%, Missing); lymph node: 61.4458% (minimum 70%, Uncertain); pancreas: 57.9545% (minimum 75%, Missing); parathyroid gland: 34.9315% (minimum 70%, Uncertain); rectum: 56.9832% (minimum 70%, Missing); retina: 35.0515% (minimum 75%, Missing); salivary gland: 57.9545% (minimum 70%, Missing); skeletal muscle: 19.5402% (minimum 75%, Missing); skin: 60.7143% (minimum 65%, Missing); small intestine: 55.7377% (minimum 75%, Missing); smooth muscle: 54.5455% (minimum 75%, Missing); spleen: 55.4348% (minimum 65%, Missing); stomach: 56.9832% (minimum 70%, Uncertain); thymus: 57.9545% (minimum 65%, Missing); thyroid gland: 36.0424% (minimum 65%, Uncertain); tongue: 25.0614% (minimum 70%, Missing); urinary bladder: 62.1951% (minimum 70%, Missing)",-0.289576,-0.449386,-0.554598,0,6,partial,42,30.5,18.1,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 2); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 2); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); smooth muscle: 8.5 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); rectum: 7.7 nTPM (protected, limit 2); colon: 7.6 nTPM (protected, limit 2); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.4 nTPM (vital, limit 1); salivary gland: 7.4 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145743,FBXL17,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.1538% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); bone marrow: 68.9189% (minimum 75%, Missing); cerebral cortex: 37.7778% (minimum 75%, Missing); colon: 57.3034% (minimum 70%, Missing); duodenum: 56.0440% (minimum 75%, Missing); esophagus: 53.9683% (minimum 70%, Missing); heart muscle: 34.0000% (minimum 75%, Missing); kidney: 44.7368% (minimum 75%, Missing); liver: 49.0385% (minimum 75%, Uncertain); lung: 60.7143% (minimum 75%, Missing); lymph node: 61.4458% (minimum 70%, Uncertain); pancreas: 57.9545% (minimum 75%, Missing); parathyroid gland: 34.9315% (minimum 70%, Uncertain); rectum: 56.9832% (minimum 70%, Missing); retina: 35.0515% (minimum 75%, Missing); salivary gland: 57.9545% (minimum 70%, Missing); skeletal muscle: 19.5402% (minimum 75%, Missing); skin: 60.7143% (minimum 65%, Missing); small intestine: 55.7377% (minimum 75%, Missing); smooth muscle: 54.5455% (minimum 75%, Missing); spleen: 55.4348% (minimum 65%, Missing); stomach: 56.9832% (minimum 70%, Uncertain); thymus: 57.9545% (minimum 65%, Missing); thyroid gland: 36.0424% (minimum 65%, Uncertain); tongue: 25.0614% (minimum 70%, Missing); urinary bladder: 62.1951% (minimum 70%, Missing)",-0.289576,-0.449386,-0.554598,0,6,partial,42,30.5,18.1,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 3); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 3); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 3); smooth muscle: 8.5 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); rectum: 7.7 nTPM (protected, limit 3); colon: 7.6 nTPM (protected, limit 3); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.4 nTPM (vital, limit 1); salivary gland: 7.4 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145743,FBXL17,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.1538% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); bone marrow: 68.9189% (minimum 75%, Missing); cerebral cortex: 37.7778% (minimum 75%, Missing); colon: 57.3034% (minimum 70%, Missing); duodenum: 56.0440% (minimum 75%, Missing); esophagus: 53.9683% (minimum 70%, Missing); heart muscle: 34.0000% (minimum 75%, Missing); kidney: 44.7368% (minimum 75%, Missing); liver: 49.0385% (minimum 75%, Uncertain); lung: 60.7143% (minimum 75%, Missing); lymph node: 61.4458% (minimum 70%, Uncertain); pancreas: 57.9545% (minimum 75%, Missing); parathyroid gland: 34.9315% (minimum 70%, Uncertain); rectum: 56.9832% (minimum 70%, Missing); retina: 35.0515% (minimum 75%, Missing); salivary gland: 57.9545% (minimum 70%, Missing); skeletal muscle: 19.5402% (minimum 75%, Missing); skin: 60.7143% (minimum 65%, Missing); small intestine: 55.7377% (minimum 75%, Missing); smooth muscle: 54.5455% (minimum 75%, Missing); spleen: 55.4348% (minimum 65%, Missing); stomach: 56.9832% (minimum 70%, Uncertain); thymus: 57.9545% (minimum 65%, Missing); thyroid gland: 36.0424% (minimum 65%, Uncertain); tongue: 25.0614% (minimum 70%, Missing); urinary bladder: 62.1951% (minimum 70%, Missing)",-0.289576,-0.449386,-0.554598,0,6,partial,42,30.5,18.1,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 3); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 3); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 3); smooth muscle: 8.5 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); rectum: 7.7 nTPM (protected, limit 3); colon: 7.6 nTPM (protected, limit 3); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.4 nTPM (vital, limit 1); salivary gland: 7.4 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145743,FBXL17,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.1538% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 68.9189% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 37.7778% (minimum 75%, Baseline (adaptation disabled)); colon: 57.3034% (minimum 70%, Baseline (adaptation disabled)); duodenum: 56.0440% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.9683% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 34.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 44.7368% (minimum 75%, Baseline (adaptation disabled)); liver: 49.0385% (minimum 75%, Baseline (adaptation disabled)); lung: 60.7143% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.4458% (minimum 70%, Baseline (adaptation disabled)); pancreas: 57.9545% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 34.9315% (minimum 70%, Baseline (adaptation disabled)); rectum: 56.9832% (minimum 70%, Baseline (adaptation disabled)); retina: 35.0515% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 57.9545% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 19.5402% (minimum 75%, Baseline (adaptation disabled)); skin: 60.7143% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.7377% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 54.5455% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.4348% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.9832% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.9545% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 36.0424% (minimum 65%, Baseline (adaptation disabled)); tongue: 25.0614% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.1951% (minimum 70%, Baseline (adaptation disabled))",-0.289576,-0.449386,-0.554598,0,6,partial,42,30.5,18.1,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 3); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 3); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 3); smooth muscle: 8.5 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); rectum: 7.7 nTPM (protected, limit 3); colon: 7.6 nTPM (protected, limit 3); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.4 nTPM (vital, limit 1); salivary gland: 7.4 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145743,FBXL17,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"pancreas: 98.8593% (minimum 99%, Missing)",0.05,0.0223664,-0.00140684,0,4,partial,0.3,0.2,1,,caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145757,SPATA9,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.292366,0.238593,0,4,partial,0.3,0.2,1,,caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145757,SPATA9,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.292366,0.238593,0,4,partial,0.3,0.2,1,,caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145757,SPATA9,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.292366,0.238593,0,4,partial,0.3,0.2,1,,caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145757,SPATA9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.312963,0.292366,0.238593,0,4,partial,0.3,0.2,1,,caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145757,SPATA9,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 89.8588% (minimum 99%, Missing); kidney: 97.6971% (minimum 98%, Approved); liver: 89.8588% (minimum 98%, Approved); lymph node: 72.2022% (minimum 97%, Missing); spleen: 94.7226% (minimum 95%, Missing); thymus: 86.5266% (minimum 95%, Missing)",-0.0847342,-0.247978,-0.0914121,0,4,partial,15.8,53.9,21.8,"lymph node: 53.9 nTPM (protected, limit 2); thymus: 21.8 nTPM (manageable, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 2); adipose tissue: 14.3 nTPM (manageable, limit 10); spleen: 7.8 nTPM (manageable, limit 5); urinary bladder: 4.7 nTPM (protected, limit 4); kidney: 3.3 nTPM (vital, limit 2); choroid plexus: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145850,TIMD4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.215266,0.0220217,0.148588,0,4,partial,15.8,53.9,21.8,"lymph node: 53.9 nTPM (protected, limit 2); thymus: 21.8 nTPM (manageable, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 2); adipose tissue: 14.3 nTPM (manageable, limit 10); spleen: 7.8 nTPM (manageable, limit 5); urinary bladder: 4.7 nTPM (protected, limit 4); kidney: 3.3 nTPM (vital, limit 2); choroid plexus: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145850,TIMD4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.215266,0.0220217,0.148588,0,4,partial,15.8,53.9,21.8,"lymph node: 53.9 nTPM (protected, limit 3); thymus: 21.8 nTPM (manageable, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 2); adipose tissue: 14.3 nTPM (manageable, limit 10); spleen: 7.8 nTPM (manageable, limit 5); urinary bladder: 4.7 nTPM (protected, limit 4); kidney: 3.3 nTPM (vital, limit 2); choroid plexus: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145850,TIMD4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.215266,0.0220217,0.148588,0,4,partial,15.8,53.9,21.8,"lymph node: 53.9 nTPM (protected, limit 3); thymus: 21.8 nTPM (manageable, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 2); adipose tissue: 14.3 nTPM (manageable, limit 10); spleen: 7.8 nTPM (manageable, limit 5); urinary bladder: 4.7 nTPM (protected, limit 4); kidney: 3.3 nTPM (vital, limit 2); choroid plexus: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145850,TIMD4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.215266,0.0220217,0.148588,0,4,partial,15.8,53.9,21.8,"lymph node: 53.9 nTPM (protected, limit 3); thymus: 21.8 nTPM (manageable, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); urinary bladder: 4.7 nTPM (protected, limit 3); kidney: 3.3 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145850,TIMD4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.2075% (minimum 90%, Approved); adrenal gland: 55.9524% (minimum 99%, Missing); amygdala: 67.4641% (minimum 99%, Missing); basal ganglia: 65.5814% (minimum 99%, Missing); bone marrow: 59.2437% (minimum 98%, Approved); cerebellum: 56.1753% (minimum 99%, Missing); cerebral cortex: 60.7759% (minimum 99%, Missing); choroid plexus: 64.3836% (minimum 99%, Missing); colon: 53.8168% (minimum 97%, Missing); duodenum: 60.0000% (minimum 99%, Missing); esophagus: 58.0247% (minimum 97%, Missing); heart muscle: 45.6311% (minimum 99%, Missing); hippocampal formation: 64.9770% (minimum 99%, Missing); hypothalamus: 65.8879% (minimum 99%, Missing); kidney: 53.0075% (minimum 99%, Missing); liver: 44.6203% (minimum 99%, Missing); lung: 50.0000% (minimum 99%, Missing); lymph node: 49.8233% (minimum 95%, Approved); midbrain: 64.6789% (minimum 99%, Missing); pancreas: 60.5150% (minimum 99%, Missing); parathyroid gland: 44.0625% (minimum 97%, Missing); pituitary gland: 58.7500% (minimum 99%, Missing); rectum: 52.8090% (minimum 97%, Missing); retina: 57.0850% (minimum 99%, Missing); salivary gland: 55.7312% (minimum 97%, Missing); skeletal muscle: 43.9252% (minimum 98%, Approved); skin: 54.4402% (minimum 95%, Missing); small intestine: 55.5118% (minimum 99%, Missing); smooth muscle: 54.4402% (minimum 99%, Missing); spinal cord: 60.2564% (minimum 99%, Missing); spleen: 50.1779% (minimum 90%, Approved); stomach: 53.8168% (minimum 97%, Missing); thymus: 41.7160% (minimum 95%, Missing); thyroid gland: 54.2308% (minimum 95%, Missing); tongue: 46.5347% (minimum 97%, Missing); urinary bladder: 51.4599% (minimum 97%, Missing)",-0.53284,-0.529375,-0.543797,0,3,partial,18,17.9,19.7,"thymus: 19.7 nTPM (manageable, limit 5); skeletal muscle: 18 nTPM (vital, limit 2); parathyroid gland: 17.9 nTPM (protected, limit 2); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 2); lymph node: 14.2 nTPM (protected, limit 4); lung: 14.1 nTPM (vital, limit 1); spleen: 14 nTPM (manageable, limit 10); urinary bladder: 13.3 nTPM (protected, limit 2); rectum: 12.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (manageable, limit 10); colon: 12.1 nTPM (protected, limit 2); stomach: 12.1 nTPM (protected, limit 2); thyroid gland: 11.9 nTPM (manageable, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); small intestine: 11.3 nTPM (vital, limit 1); salivary gland: 11.2 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 2); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 2); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145868,FBXO38,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.2075% (minimum 60%, Approved); adrenal gland: 55.9524% (minimum 75%, Missing); amygdala: 67.4641% (minimum 75%, Missing); basal ganglia: 65.5814% (minimum 75%, Missing); bone marrow: 59.2437% (minimum 70%, Approved); cerebellum: 56.1753% (minimum 75%, Missing); cerebral cortex: 60.7759% (minimum 75%, Missing); choroid plexus: 64.3836% (minimum 75%, Missing); colon: 53.8168% (minimum 70%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 58.0247% (minimum 70%, Missing); heart muscle: 45.6311% (minimum 75%, Missing); hippocampal formation: 64.9770% (minimum 75%, Missing); hypothalamus: 65.8879% (minimum 75%, Missing); kidney: 53.0075% (minimum 75%, Missing); liver: 44.6203% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 49.8233% (minimum 65%, Approved); midbrain: 64.6789% (minimum 75%, Missing); pancreas: 60.5150% (minimum 75%, Missing); parathyroid gland: 44.0625% (minimum 70%, Missing); pituitary gland: 58.7500% (minimum 75%, Missing); rectum: 52.8090% (minimum 70%, Missing); retina: 57.0850% (minimum 75%, Missing); salivary gland: 55.7312% (minimum 70%, Missing); skeletal muscle: 43.9252% (minimum 70%, Approved); skin: 54.4402% (minimum 65%, Missing); small intestine: 55.5118% (minimum 75%, Missing); smooth muscle: 54.4402% (minimum 75%, Missing); spinal cord: 60.2564% (minimum 75%, Missing); spleen: 50.1779% (minimum 60%, Approved); stomach: 53.8168% (minimum 70%, Missing); thymus: 41.7160% (minimum 65%, Missing); thyroid gland: 54.2308% (minimum 65%, Missing); tongue: 46.5347% (minimum 70%, Missing); urinary bladder: 51.4599% (minimum 70%, Missing)",-0.23284,-0.259375,-0.303797,0,3,partial,18,17.9,19.7,"thymus: 19.7 nTPM (manageable, limit 5); skeletal muscle: 18 nTPM (vital, limit 2); parathyroid gland: 17.9 nTPM (protected, limit 2); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 2); lymph node: 14.2 nTPM (protected, limit 4); lung: 14.1 nTPM (vital, limit 1); spleen: 14 nTPM (manageable, limit 10); urinary bladder: 13.3 nTPM (protected, limit 2); rectum: 12.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (manageable, limit 10); colon: 12.1 nTPM (protected, limit 2); stomach: 12.1 nTPM (protected, limit 2); thyroid gland: 11.9 nTPM (manageable, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); small intestine: 11.3 nTPM (vital, limit 1); salivary gland: 11.2 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 2); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 2); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145868,FBXO38,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.2075% (minimum 60%, Approved); adrenal gland: 55.9524% (minimum 75%, Missing); amygdala: 67.4641% (minimum 75%, Missing); basal ganglia: 65.5814% (minimum 75%, Missing); bone marrow: 59.2437% (minimum 70%, Approved); cerebellum: 56.1753% (minimum 75%, Missing); cerebral cortex: 60.7759% (minimum 75%, Missing); choroid plexus: 64.3836% (minimum 75%, Missing); colon: 53.8168% (minimum 70%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 58.0247% (minimum 70%, Missing); heart muscle: 45.6311% (minimum 75%, Missing); hippocampal formation: 64.9770% (minimum 75%, Missing); hypothalamus: 65.8879% (minimum 75%, Missing); kidney: 53.0075% (minimum 75%, Missing); liver: 44.6203% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 49.8233% (minimum 65%, Approved); midbrain: 64.6789% (minimum 75%, Missing); pancreas: 60.5150% (minimum 75%, Missing); parathyroid gland: 44.0625% (minimum 70%, Missing); pituitary gland: 58.7500% (minimum 75%, Missing); rectum: 52.8090% (minimum 70%, Missing); retina: 57.0850% (minimum 75%, Missing); salivary gland: 55.7312% (minimum 70%, Missing); skeletal muscle: 43.9252% (minimum 70%, Approved); skin: 54.4402% (minimum 65%, Missing); small intestine: 55.5118% (minimum 75%, Missing); smooth muscle: 54.4402% (minimum 75%, Missing); spinal cord: 60.2564% (minimum 75%, Missing); spleen: 50.1779% (minimum 60%, Approved); stomach: 53.8168% (minimum 70%, Missing); thymus: 41.7160% (minimum 65%, Missing); thyroid gland: 54.2308% (minimum 65%, Missing); tongue: 46.5347% (minimum 70%, Missing); urinary bladder: 51.4599% (minimum 70%, Missing)",-0.23284,-0.259375,-0.303797,0,3,partial,18,17.9,19.7,"thymus: 19.7 nTPM (manageable, limit 5); skeletal muscle: 18 nTPM (vital, limit 2); parathyroid gland: 17.9 nTPM (protected, limit 3); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 3); lymph node: 14.2 nTPM (protected, limit 4); lung: 14.1 nTPM (vital, limit 1); spleen: 14 nTPM (manageable, limit 10); urinary bladder: 13.3 nTPM (protected, limit 3); rectum: 12.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (manageable, limit 10); colon: 12.1 nTPM (protected, limit 3); stomach: 12.1 nTPM (protected, limit 3); thyroid gland: 11.9 nTPM (manageable, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); small intestine: 11.3 nTPM (vital, limit 1); salivary gland: 11.2 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 3); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 2); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145868,FBXO38,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.2075% (minimum 60%, Approved); adrenal gland: 55.9524% (minimum 75%, Missing); amygdala: 67.4641% (minimum 75%, Missing); basal ganglia: 65.5814% (minimum 75%, Missing); bone marrow: 59.2437% (minimum 70%, Approved); cerebellum: 56.1753% (minimum 75%, Missing); cerebral cortex: 60.7759% (minimum 75%, Missing); choroid plexus: 64.3836% (minimum 75%, Missing); colon: 53.8168% (minimum 70%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 58.0247% (minimum 70%, Missing); heart muscle: 45.6311% (minimum 75%, Missing); hippocampal formation: 64.9770% (minimum 75%, Missing); hypothalamus: 65.8879% (minimum 75%, Missing); kidney: 53.0075% (minimum 75%, Missing); liver: 44.6203% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 49.8233% (minimum 65%, Approved); midbrain: 64.6789% (minimum 75%, Missing); pancreas: 60.5150% (minimum 75%, Missing); parathyroid gland: 44.0625% (minimum 70%, Missing); pituitary gland: 58.7500% (minimum 75%, Missing); rectum: 52.8090% (minimum 70%, Missing); retina: 57.0850% (minimum 75%, Missing); salivary gland: 55.7312% (minimum 70%, Missing); skeletal muscle: 43.9252% (minimum 70%, Approved); skin: 54.4402% (minimum 65%, Missing); small intestine: 55.5118% (minimum 75%, Missing); smooth muscle: 54.4402% (minimum 75%, Missing); spinal cord: 60.2564% (minimum 75%, Missing); spleen: 50.1779% (minimum 60%, Approved); stomach: 53.8168% (minimum 70%, Missing); thymus: 41.7160% (minimum 65%, Missing); thyroid gland: 54.2308% (minimum 65%, Missing); tongue: 46.5347% (minimum 70%, Missing); urinary bladder: 51.4599% (minimum 70%, Missing)",-0.23284,-0.259375,-0.303797,0,3,partial,18,17.9,19.7,"thymus: 19.7 nTPM (manageable, limit 5); skeletal muscle: 18 nTPM (vital, limit 2); parathyroid gland: 17.9 nTPM (protected, limit 3); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 3); lymph node: 14.2 nTPM (protected, limit 4); lung: 14.1 nTPM (vital, limit 1); spleen: 14 nTPM (manageable, limit 10); urinary bladder: 13.3 nTPM (protected, limit 3); rectum: 12.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (manageable, limit 10); colon: 12.1 nTPM (protected, limit 3); stomach: 12.1 nTPM (protected, limit 3); thyroid gland: 11.9 nTPM (manageable, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); small intestine: 11.3 nTPM (vital, limit 1); salivary gland: 11.2 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 3); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 2); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145868,FBXO38,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.2075% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 55.9524% (minimum 75%, Baseline (adaptation disabled)); amygdala: 67.4641% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.5814% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 59.2437% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.1753% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.7759% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.3836% (minimum 75%, Baseline (adaptation disabled)); colon: 53.8168% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 58.0247% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 45.6311% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.9770% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.8879% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.0075% (minimum 75%, Baseline (adaptation disabled)); liver: 44.6203% (minimum 75%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.8233% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.6789% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.5150% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 44.0625% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.7500% (minimum 75%, Baseline (adaptation disabled)); rectum: 52.8090% (minimum 70%, Baseline (adaptation disabled)); retina: 57.0850% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.7312% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 43.9252% (minimum 75%, Baseline (adaptation disabled)); skin: 54.4402% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.5118% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 54.4402% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 60.2564% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.1779% (minimum 65%, Baseline (adaptation disabled)); stomach: 53.8168% (minimum 70%, Baseline (adaptation disabled)); thymus: 41.7160% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.2308% (minimum 65%, Baseline (adaptation disabled)); tongue: 46.5347% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.4599% (minimum 70%, Baseline (adaptation disabled))",-0.23284,-0.259375,-0.310748,0,3,partial,18,17.9,19.7,"thymus: 19.7 nTPM (manageable, limit 5); skeletal muscle: 18 nTPM (vital, limit 1); parathyroid gland: 17.9 nTPM (protected, limit 3); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 3); lymph node: 14.2 nTPM (protected, limit 3); lung: 14.1 nTPM (vital, limit 1); spleen: 14 nTPM (manageable, limit 5); urinary bladder: 13.3 nTPM (protected, limit 3); rectum: 12.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.1 nTPM (protected, limit 3); stomach: 12.1 nTPM (protected, limit 3); thyroid gland: 11.9 nTPM (manageable, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); small intestine: 11.3 nTPM (vital, limit 1); salivary gland: 11.2 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 3); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 1); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145868,FBXO38,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 97.9730% (minimum 99%, Missing); pancreas: 90.6250% (minimum 99%, Missing)",0.05,0.03,-0.08375,0,80,unavailable,1.5,0,0,"pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145975,FAM217A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.15625,0,80,unavailable,1.5,0,0,"pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145975,FAM217A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.15625,0,80,unavailable,1.5,0,0,"pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145975,FAM217A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.15625,0,80,unavailable,1.5,0,0,"pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145975,FAM217A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.15625,0,80,unavailable,1.5,0,0,"pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145975,FAM217A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.0702% (minimum 90%, Approved); adrenal gland: 62.5806% (minimum 99%, Missing); amygdala: 59.8765% (minimum 99%, Missing); basal ganglia: 61.5873% (minimum 99%, Missing); bone marrow: 42.6374% (minimum 98%, Approved); cerebellum: 64.4518% (minimum 98%, Approved); cerebral cortex: 51.1873% (minimum 99%, Missing); choroid plexus: 67.5958% (minimum 99%, Missing); colon: 56.8915% (minimum 95%, Approved); duodenum: 57.9104% (minimum 99%, Missing); esophagus: 53.7396% (minimum 95%, Approved); heart muscle: 38.8778% (minimum 98%, Approved); hippocampal formation: 58.7879% (minimum 99%, Missing); hypothalamus: 60.4361% (minimum 99%, Missing); kidney: 48.6216% (minimum 99%, Missing); liver: 53.1507% (minimum 99%, Missing); lung: 64.6667% (minimum 98%, Approved); lymph node: 58.7879% (minimum 95%, Approved); midbrain: 61.3924% (minimum 99%, Missing); pancreas: 66.2116% (minimum 99%, Missing); parathyroid gland: 61.7834% (minimum 97%, Missing); pituitary gland: 65.1007% (minimum 99%, Missing); rectum: 54.9575% (minimum 95%, Approved); retina: 63.6066% (minimum 99%, Missing); salivary gland: 62.1795% (minimum 95%, Approved); skeletal muscle: 55.2707% (minimum 98%, Approved); skin: 59.3272% (minimum 90%, Approved); small intestine: 64.8829% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 98%, Approved); spinal cord: 60.0619% (minimum 99%, Missing); spleen: 61.7834% (minimum 90%, Approved); stomach: 67.1280% (minimum 95%, Approved); thymus: 54.1899% (minimum 95%, Missing); thyroid gland: 71.3235% (minimum 90%, Approved); tongue: 58.2583% (minimum 97%, Missing); urinary bladder: 66.8966% (minimum 95%, Approved)",-0.408101,-0.412604,-0.591222,0,3,partial,30.5,16.7,16.4,"heart muscle: 30.5 nTPM (vital, limit 2); bone marrow: 26.1 nTPM (vital, limit 2); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 15.9 nTPM (protected, limit 4); skeletal muscle: 15.7 nTPM (vital, limit 2); colon: 14.7 nTPM (protected, limit 4); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 2); lymph node: 13.6 nTPM (protected, limit 4); hippocampal formation: 13.6 nTPM (vital, limit 1); skin: 13.3 nTPM (manageable, limit 10); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); spleen: 12 nTPM (manageable, limit 10); parathyroid gland: 12 nTPM (protected, limit 2); salivary gland: 11.8 nTPM (protected, limit 4); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 2); lung: 10.6 nTPM (vital, limit 2); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 2); urinary bladder: 9.6 nTPM (protected, limit 4); stomach: 9.5 nTPM (protected, limit 4); choroid plexus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145979,TBC1D7,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.5806% (minimum 75%, Missing); amygdala: 59.8765% (minimum 75%, Missing); basal ganglia: 61.5873% (minimum 75%, Missing); bone marrow: 42.6374% (minimum 70%, Approved); cerebellum: 64.4518% (minimum 70%, Approved); cerebral cortex: 51.1873% (minimum 75%, Missing); choroid plexus: 67.5958% (minimum 75%, Missing); colon: 56.8915% (minimum 65%, Approved); duodenum: 57.9104% (minimum 75%, Missing); esophagus: 53.7396% (minimum 65%, Approved); heart muscle: 38.8778% (minimum 70%, Approved); hippocampal formation: 58.7879% (minimum 75%, Missing); hypothalamus: 60.4361% (minimum 75%, Missing); kidney: 48.6216% (minimum 75%, Missing); liver: 53.1507% (minimum 75%, Missing); lung: 64.6667% (minimum 70%, Approved); lymph node: 58.7879% (minimum 65%, Approved); midbrain: 61.3924% (minimum 75%, Missing); pancreas: 66.2116% (minimum 75%, Missing); parathyroid gland: 61.7834% (minimum 70%, Missing); pituitary gland: 65.1007% (minimum 75%, Missing); rectum: 54.9575% (minimum 65%, Approved); retina: 63.6066% (minimum 75%, Missing); salivary gland: 62.1795% (minimum 65%, Approved); skeletal muscle: 55.2707% (minimum 70%, Approved); skin: 59.3272% (minimum 60%, Approved); small intestine: 64.8829% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 70%, Approved); spinal cord: 60.0619% (minimum 75%, Missing); thymus: 54.1899% (minimum 65%, Missing); tongue: 58.2583% (minimum 70%, Missing)",-0.108101,-0.117417,-0.311222,0,3,partial,30.5,16.7,16.4,"heart muscle: 30.5 nTPM (vital, limit 2); bone marrow: 26.1 nTPM (vital, limit 2); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 15.9 nTPM (protected, limit 4); skeletal muscle: 15.7 nTPM (vital, limit 2); colon: 14.7 nTPM (protected, limit 4); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 2); lymph node: 13.6 nTPM (protected, limit 4); hippocampal formation: 13.6 nTPM (vital, limit 1); skin: 13.3 nTPM (manageable, limit 10); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); spleen: 12 nTPM (manageable, limit 10); parathyroid gland: 12 nTPM (protected, limit 2); salivary gland: 11.8 nTPM (protected, limit 4); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 2); lung: 10.6 nTPM (vital, limit 2); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 2); urinary bladder: 9.6 nTPM (protected, limit 4); stomach: 9.5 nTPM (protected, limit 4); choroid plexus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145979,TBC1D7,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.5806% (minimum 75%, Missing); amygdala: 59.8765% (minimum 75%, Missing); basal ganglia: 61.5873% (minimum 75%, Missing); bone marrow: 42.6374% (minimum 70%, Approved); cerebellum: 64.4518% (minimum 70%, Approved); cerebral cortex: 51.1873% (minimum 75%, Missing); choroid plexus: 67.5958% (minimum 75%, Missing); colon: 56.8915% (minimum 65%, Approved); duodenum: 57.9104% (minimum 75%, Missing); esophagus: 53.7396% (minimum 65%, Approved); heart muscle: 38.8778% (minimum 70%, Approved); hippocampal formation: 58.7879% (minimum 75%, Missing); hypothalamus: 60.4361% (minimum 75%, Missing); kidney: 48.6216% (minimum 75%, Missing); liver: 53.1507% (minimum 75%, Missing); lung: 64.6667% (minimum 70%, Approved); lymph node: 58.7879% (minimum 65%, Approved); midbrain: 61.3924% (minimum 75%, Missing); pancreas: 66.2116% (minimum 75%, Missing); parathyroid gland: 61.7834% (minimum 70%, Missing); pituitary gland: 65.1007% (minimum 75%, Missing); rectum: 54.9575% (minimum 65%, Approved); retina: 63.6066% (minimum 75%, Missing); salivary gland: 62.1795% (minimum 65%, Approved); skeletal muscle: 55.2707% (minimum 70%, Approved); skin: 59.3272% (minimum 60%, Approved); small intestine: 64.8829% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 70%, Approved); spinal cord: 60.0619% (minimum 75%, Missing); thymus: 54.1899% (minimum 65%, Missing); tongue: 58.2583% (minimum 70%, Missing)",-0.108101,-0.117417,-0.311222,0,3,partial,30.5,16.7,16.4,"heart muscle: 30.5 nTPM (vital, limit 2); bone marrow: 26.1 nTPM (vital, limit 2); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 15.9 nTPM (protected, limit 4); skeletal muscle: 15.7 nTPM (vital, limit 2); colon: 14.7 nTPM (protected, limit 4); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 3); lymph node: 13.6 nTPM (protected, limit 4); hippocampal formation: 13.6 nTPM (vital, limit 1); skin: 13.3 nTPM (manageable, limit 10); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); spleen: 12 nTPM (manageable, limit 10); parathyroid gland: 12 nTPM (protected, limit 3); salivary gland: 11.8 nTPM (protected, limit 4); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 2); lung: 10.6 nTPM (vital, limit 2); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 2); urinary bladder: 9.6 nTPM (protected, limit 4); stomach: 9.5 nTPM (protected, limit 4); choroid plexus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145979,TBC1D7,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.5806% (minimum 75%, Missing); amygdala: 59.8765% (minimum 75%, Missing); basal ganglia: 61.5873% (minimum 75%, Missing); bone marrow: 42.6374% (minimum 70%, Approved); cerebellum: 64.4518% (minimum 70%, Approved); cerebral cortex: 51.1873% (minimum 75%, Missing); choroid plexus: 67.5958% (minimum 75%, Missing); colon: 56.8915% (minimum 65%, Approved); duodenum: 57.9104% (minimum 75%, Missing); esophagus: 53.7396% (minimum 65%, Approved); heart muscle: 38.8778% (minimum 70%, Approved); hippocampal formation: 58.7879% (minimum 75%, Missing); hypothalamus: 60.4361% (minimum 75%, Missing); kidney: 48.6216% (minimum 75%, Missing); liver: 53.1507% (minimum 75%, Missing); lung: 64.6667% (minimum 70%, Approved); lymph node: 58.7879% (minimum 65%, Approved); midbrain: 61.3924% (minimum 75%, Missing); pancreas: 66.2116% (minimum 75%, Missing); parathyroid gland: 61.7834% (minimum 70%, Missing); pituitary gland: 65.1007% (minimum 75%, Missing); rectum: 54.9575% (minimum 65%, Approved); retina: 63.6066% (minimum 75%, Missing); salivary gland: 62.1795% (minimum 65%, Approved); skeletal muscle: 55.2707% (minimum 70%, Approved); skin: 59.3272% (minimum 60%, Approved); small intestine: 64.8829% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 70%, Approved); spinal cord: 60.0619% (minimum 75%, Missing); thymus: 54.1899% (minimum 65%, Missing); tongue: 58.2583% (minimum 70%, Missing)",-0.108101,-0.117417,-0.311222,0,3,partial,30.5,16.7,16.4,"heart muscle: 30.5 nTPM (vital, limit 2); bone marrow: 26.1 nTPM (vital, limit 2); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 15.9 nTPM (protected, limit 4); skeletal muscle: 15.7 nTPM (vital, limit 2); colon: 14.7 nTPM (protected, limit 4); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 3); lymph node: 13.6 nTPM (protected, limit 4); hippocampal formation: 13.6 nTPM (vital, limit 1); skin: 13.3 nTPM (manageable, limit 10); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); spleen: 12 nTPM (manageable, limit 10); parathyroid gland: 12 nTPM (protected, limit 3); salivary gland: 11.8 nTPM (protected, limit 4); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 2); lung: 10.6 nTPM (vital, limit 2); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 2); urinary bladder: 9.6 nTPM (protected, limit 4); stomach: 9.5 nTPM (protected, limit 4); choroid plexus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145979,TBC1D7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.5806% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.8765% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.5873% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 42.6374% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.4518% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.1873% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.5958% (minimum 75%, Baseline (adaptation disabled)); colon: 56.8915% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.9104% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.7396% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 38.8778% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.7879% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.4361% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.6216% (minimum 75%, Baseline (adaptation disabled)); liver: 53.1507% (minimum 75%, Baseline (adaptation disabled)); lung: 64.6667% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.7879% (minimum 70%, Baseline (adaptation disabled)); midbrain: 61.3924% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.2116% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.7834% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 65.1007% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.9575% (minimum 70%, Baseline (adaptation disabled)); retina: 63.6066% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.1795% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.2707% (minimum 75%, Baseline (adaptation disabled)); skin: 59.3272% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.8829% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 60.0619% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.7834% (minimum 65%, Baseline (adaptation disabled)); stomach: 67.1280% (minimum 70%, Baseline (adaptation disabled)); thymus: 54.1899% (minimum 65%, Baseline (adaptation disabled)); tongue: 58.2583% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 66.8966% (minimum 70%, Baseline (adaptation disabled))",-0.108101,-0.162604,-0.361222,0,3,partial,30.5,16.7,16.4,"heart muscle: 30.5 nTPM (vital, limit 1); bone marrow: 26.1 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 3); thymus: 16.4 nTPM (manageable, limit 5); rectum: 15.9 nTPM (protected, limit 3); skeletal muscle: 15.7 nTPM (vital, limit 1); colon: 14.7 nTPM (protected, limit 3); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 3); hippocampal formation: 13.6 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 3); skin: 13.3 nTPM (manageable, limit 5); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); parathyroid gland: 12 nTPM (protected, limit 3); spleen: 12 nTPM (manageable, limit 5); salivary gland: 11.8 nTPM (protected, limit 3); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); urinary bladder: 9.6 nTPM (protected, limit 3); stomach: 9.5 nTPM (protected, limit 3); choroid plexus: 9.3 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); thyroid gland: 7.8 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000145979,TBC1D7,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,family_exclusion,True,True,True,,0.05,0.03,0.01,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146047,H2BC1,admission_only,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146047,H2BC1,selectivity_revised,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146047,H2BC1,grid_revised,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146047,H2BC1,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.35,0.3,0.234127,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146047,H2BC1,current_fixed,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.4025% (minimum 99%, Missing); basal ganglia: 91.8239% (minimum 99%, Missing); bone marrow: 97.0100% (minimum 99%, Missing); cerebellum: 79.3478% (minimum 99%, Missing); cerebral cortex: 91.5361% (minimum 99%, Missing); choroid plexus: 95.7377% (minimum 99%, Missing); hippocampal formation: 87.1642% (minimum 99%, Missing); hypothalamus: 91.2500% (minimum 99%, Missing); lung: 95.4248% (minimum 99%, Missing); midbrain: 95.4248% (minimum 99%, Missing); pituitary gland: 98.3165% (minimum 99%, Missing); retina: 96.6887% (minimum 99%, Missing); spinal cord: 96.0526% (minimum 99%, Missing)",0.033165,0.0231973,-0.196522,0,80,unavailable,7.6,0.2,0.5,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146221,TCTE1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333165,0.293197,0.0434783,0,80,unavailable,7.6,0.2,0.5,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146221,TCTE1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333165,0.293197,0.0434783,0,80,unavailable,7.6,0.2,0.5,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146221,TCTE1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333165,0.293197,0.0434783,0,80,unavailable,7.6,0.2,0.5,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146221,TCTE1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333165,0.293197,0.0434783,0,80,unavailable,7.6,0.2,0.5,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146221,TCTE1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 74.1379% (minimum 95%, Missing); adrenal gland: 71.6667% (minimum 99%, Missing); amygdala: 78.1818% (minimum 99%, Missing); basal ganglia: 70.4918% (minimum 99%, Missing); bone marrow: 44.7917% (minimum 99%, Missing); cerebellum: 74.1379% (minimum 99%, Missing); cerebral cortex: 72.8814% (minimum 99%, Missing); choroid plexus: 69.3548% (minimum 99%, Missing); colon: 72.8814% (minimum 97%, Missing); duodenum: 79.6296% (minimum 99%, Missing); esophagus: 78.1818% (minimum 97%, Missing); heart muscle: 72.8814% (minimum 99%, Missing); hippocampal formation: 76.7857% (minimum 99%, Missing); hypothalamus: 74.1379% (minimum 99%, Missing); kidney: 60.5634% (minimum 99%, Missing); liver: 82.6923% (minimum 99%, Missing); lung: 67.1875% (minimum 99%, Missing); lymph node: 70.4918% (minimum 97%, Missing); midbrain: 79.6296% (minimum 99%, Missing); pancreas: 58.1081% (minimum 99%, Missing); parathyroid gland: 55.1282% (minimum 97%, Missing); pituitary gland: 56.5789% (minimum 99%, Missing); rectum: 76.7857% (minimum 97%, Missing); retina: 44.3299% (minimum 99%, Missing); salivary gland: 62.3188% (minimum 97%, Missing); skeletal muscle: 79.6296% (minimum 99%, Missing); skin: 66.1538% (minimum 95%, Missing); small intestine: 75.4386% (minimum 99%, Missing); smooth muscle: 68.2540% (minimum 99%, Missing); spinal cord: 79.6296% (minimum 99%, Missing); spleen: 69.3548% (minimum 95%, Missing); stomach: 56.5789% (minimum 97%, Missing); thymus: 59.7222% (minimum 95%, Missing); thyroid gland: 57.3333% (minimum 95%, Missing); tongue: 81.1321% (minimum 97%, Missing); urinary bladder: 75.4386% (minimum 97%, Missing)",-0.376667,-0.418718,-0.546701,0,80,unavailable,5.4,3.5,3.2,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); stomach: 3.3 nTPM (protected, limit 2); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146243,IRAK1BP1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.6667% (minimum 75%, Missing); basal ganglia: 70.4918% (minimum 75%, Missing); bone marrow: 44.7917% (minimum 75%, Missing); cerebellum: 74.1379% (minimum 75%, Missing); cerebral cortex: 72.8814% (minimum 75%, Missing); choroid plexus: 69.3548% (minimum 75%, Missing); heart muscle: 72.8814% (minimum 75%, Missing); hypothalamus: 74.1379% (minimum 75%, Missing); kidney: 60.5634% (minimum 75%, Missing); lung: 67.1875% (minimum 75%, Missing); pancreas: 58.1081% (minimum 75%, Missing); parathyroid gland: 55.1282% (minimum 70%, Missing); pituitary gland: 56.5789% (minimum 75%, Missing); retina: 44.3299% (minimum 75%, Missing); salivary gland: 62.3188% (minimum 70%, Missing); smooth muscle: 68.2540% (minimum 75%, Missing); stomach: 56.5789% (minimum 70%, Missing); thymus: 59.7222% (minimum 65%, Missing); thyroid gland: 57.3333% (minimum 65%, Missing)",-0.0766667,-0.148718,-0.306701,0,80,unavailable,5.4,3.5,3.2,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); stomach: 3.3 nTPM (protected, limit 2); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146243,IRAK1BP1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.6667% (minimum 75%, Missing); basal ganglia: 70.4918% (minimum 75%, Missing); bone marrow: 44.7917% (minimum 75%, Missing); cerebellum: 74.1379% (minimum 75%, Missing); cerebral cortex: 72.8814% (minimum 75%, Missing); choroid plexus: 69.3548% (minimum 75%, Missing); heart muscle: 72.8814% (minimum 75%, Missing); hypothalamus: 74.1379% (minimum 75%, Missing); kidney: 60.5634% (minimum 75%, Missing); lung: 67.1875% (minimum 75%, Missing); pancreas: 58.1081% (minimum 75%, Missing); parathyroid gland: 55.1282% (minimum 70%, Missing); pituitary gland: 56.5789% (minimum 75%, Missing); retina: 44.3299% (minimum 75%, Missing); salivary gland: 62.3188% (minimum 70%, Missing); smooth muscle: 68.2540% (minimum 75%, Missing); stomach: 56.5789% (minimum 70%, Missing); thymus: 59.7222% (minimum 65%, Missing); thyroid gland: 57.3333% (minimum 65%, Missing)",-0.0766667,-0.148718,-0.306701,0,80,unavailable,5.4,3.5,3.2,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146243,IRAK1BP1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.6667% (minimum 75%, Missing); basal ganglia: 70.4918% (minimum 75%, Missing); bone marrow: 44.7917% (minimum 75%, Missing); cerebellum: 74.1379% (minimum 75%, Missing); cerebral cortex: 72.8814% (minimum 75%, Missing); choroid plexus: 69.3548% (minimum 75%, Missing); heart muscle: 72.8814% (minimum 75%, Missing); hypothalamus: 74.1379% (minimum 75%, Missing); kidney: 60.5634% (minimum 75%, Missing); lung: 67.1875% (minimum 75%, Missing); pancreas: 58.1081% (minimum 75%, Missing); parathyroid gland: 55.1282% (minimum 70%, Missing); pituitary gland: 56.5789% (minimum 75%, Missing); retina: 44.3299% (minimum 75%, Missing); salivary gland: 62.3188% (minimum 70%, Missing); smooth muscle: 68.2540% (minimum 75%, Missing); stomach: 56.5789% (minimum 70%, Missing); thymus: 59.7222% (minimum 65%, Missing); thyroid gland: 57.3333% (minimum 65%, Missing)",-0.0766667,-0.148718,-0.306701,0,80,unavailable,5.4,3.5,3.2,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146243,IRAK1BP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.6667% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.4918% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 44.7917% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.1379% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.8814% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.3548% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 72.8814% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.1379% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.5634% (minimum 75%, Baseline (adaptation disabled)); lung: 67.1875% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.1081% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.1282% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 56.5789% (minimum 75%, Baseline (adaptation disabled)); retina: 44.3299% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.3188% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 68.2540% (minimum 75%, Baseline (adaptation disabled)); stomach: 56.5789% (minimum 70%, Baseline (adaptation disabled)); thymus: 59.7222% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.3333% (minimum 65%, Baseline (adaptation disabled))",-0.0766667,-0.148718,-0.306701,0,80,unavailable,5.4,3.5,3.2,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146243,IRAK1BP1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Missing); adrenal gland: 86.8421% (minimum 99%, Missing); amygdala: 90.4110% (minimum 99%, Missing); basal ganglia: 89.1892% (minimum 99%, Missing); bone marrow: 48.5294% (minimum 99%, Missing); cerebellum: 94.2857% (minimum 99%, Missing); cerebral cortex: 90.4110% (minimum 99%, Missing); choroid plexus: 91.6667% (minimum 99%, Missing); colon: 80.4878% (minimum 97%, Missing); duodenum: 84.6154% (minimum 99%, Missing); esophagus: 80.4878% (minimum 97%, Missing); heart muscle: 91.6667% (minimum 99%, Missing); hippocampal formation: 88.0000% (minimum 99%, Missing); hypothalamus: 89.1892% (minimum 99%, Missing); kidney: 89.1892% (minimum 99%, Missing); liver: 88.0000% (minimum 99%, Missing); lung: 86.8421% (minimum 99%, Missing); lymph node: 66.0000% (minimum 97%, Missing); midbrain: 84.6154% (minimum 99%, Missing); pancreas: 84.6154% (minimum 99%, Missing); parathyroid gland: 82.5000% (minimum 97%, Missing); pituitary gland: 92.9577% (minimum 99%, Missing); rectum: 74.1573% (minimum 97%, Missing); retina: 74.1573% (minimum 99%, Missing); salivary gland: 86.8421% (minimum 97%, Missing); skeletal muscle: 92.9577% (minimum 99%, Missing); skin: 70.2128% (minimum 95%, Missing); small intestine: 80.4878% (minimum 99%, Missing); smooth muscle: 82.5000% (minimum 99%, Missing); spinal cord: 78.5714% (minimum 99%, Missing); spleen: 82.5000% (minimum 95%, Missing); stomach: 85.7143% (minimum 97%, Missing); thymus: 56.4103% (minimum 95%, Missing); thyroid gland: 85.7143% (minimum 95%, Missing); tongue: 92.9577% (minimum 97%, Missing); urinary bladder: 83.5443% (minimum 97%, Missing)",-0.385897,-0.31,-0.504706,0,80,unavailable,7,3.4,5.1,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); lymph node: 3.4 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146263,MMS22L,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.5294% (minimum 75%, Missing); lymph node: 66.0000% (minimum 70%, Missing); retina: 74.1573% (minimum 75%, Missing); thymus: 56.4103% (minimum 65%, Missing)",-0.0858974,-0.04,-0.264706,0,80,unavailable,7,3.4,5.1,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); lymph node: 3.4 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146263,MMS22L,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.5294% (minimum 75%, Missing); lymph node: 66.0000% (minimum 70%, Missing); retina: 74.1573% (minimum 75%, Missing); thymus: 56.4103% (minimum 65%, Missing)",-0.0858974,-0.04,-0.264706,0,80,unavailable,7,3.4,5.1,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); lymph node: 3.4 nTPM (protected, limit 3); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146263,MMS22L,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.5294% (minimum 75%, Missing); lymph node: 66.0000% (minimum 70%, Missing); retina: 74.1573% (minimum 75%, Missing); thymus: 56.4103% (minimum 65%, Missing)",-0.0858974,-0.04,-0.264706,0,80,unavailable,7,3.4,5.1,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); lymph node: 3.4 nTPM (protected, limit 3); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146263,MMS22L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.5294% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 74.1573% (minimum 75%, Baseline (adaptation disabled)); thymus: 56.4103% (minimum 65%, Baseline (adaptation disabled))",-0.0858974,-0.04,-0.264706,0,80,unavailable,7,3.4,5.1,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); lymph node: 3.4 nTPM (protected, limit 3); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146263,MMS22L,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 90.0000% (minimum 99%, Missing); esophagus: 90.0000% (minimum 97%, Missing); kidney: 75.0000% (minimum 99%, Missing); retina: 3.6290% (minimum 99%, Missing); skeletal muscle: 90.0000% (minimum 99%, Missing); skin: 90.0000% (minimum 95%, Missing); urinary bladder: 90.0000% (minimum 97%, Missing)",-0.05,-0.07,-0.95371,0,80,unavailable,23.9,0.1,0.1,"retina: 23.9 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146276,GABRR1,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 3.6290% (minimum 75%, Missing)",0.25,0.2,-0.71371,0,80,unavailable,23.9,0.1,0.1,"retina: 23.9 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146276,GABRR1,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 3.6290% (minimum 75%, Missing)",0.25,0.2,-0.71371,0,80,unavailable,23.9,0.1,0.1,"retina: 23.9 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146276,GABRR1,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 3.6290% (minimum 75%, Missing)",0.25,0.2,-0.71371,0,80,unavailable,23.9,0.1,0.1,"retina: 23.9 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146276,GABRR1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 3.6290% (minimum 75%, Baseline (adaptation disabled))",0.25,0.2,-0.71371,0,80,unavailable,23.9,0.1,0.1,"retina: 23.9 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146276,GABRR1,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000146378,TAAR2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000146378,TAAR2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000146378,TAAR2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000146378,TAAR2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000146378,TAAR2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.1507% (minimum 98%, Approved); amygdala: 95.7746% (minimum 99%, Missing); basal ganglia: 95.7746% (minimum 99%, Missing); bone marrow: 29.6943% (minimum 99%, Missing); cerebellum: 93.1507% (minimum 98%, Approved); cerebral cortex: 95.7746% (minimum 98%, Approved); choroid plexus: 98.5507% (minimum 99%, Missing); colon: 70.8333% (minimum 97%, Missing); duodenum: 71.5789% (minimum 99%, Missing); esophagus: 73.1183% (minimum 95%, Approved); heart muscle: 95.7746% (minimum 98%, Approved); hippocampal formation: 94.4444% (minimum 99%, Missing); hypothalamus: 95.7746% (minimum 99%, Missing); kidney: 93.1507% (minimum 98%, Approved); liver: 94.4444% (minimum 98%, Approved); lung: 86.0759% (minimum 98%, Approved); lymph node: 52.3077% (minimum 97%, Missing); midbrain: 93.1507% (minimum 99%, Missing); pancreas: 94.4444% (minimum 98%, Approved); pituitary gland: 94.4444% (minimum 99%, Missing); rectum: 65.3846% (minimum 97%, Missing); retina: 93.1507% (minimum 99%, Missing); salivary gland: 89.4737% (minimum 95%, Approved); skeletal muscle: 86.0759% (minimum 98%, Approved); skin: 78.1609% (minimum 90%, Approved); small intestine: 75.5556% (minimum 99%, Missing); smooth muscle: 87.1795% (minimum 98%, Approved); spinal cord: 94.4444% (minimum 99%, Missing); spleen: 75.5556% (minimum 90%, Approved); stomach: 86.0759% (minimum 97%, Missing); thymus: 53.1250% (minimum 95%, Missing); urinary bladder: 89.4737% (minimum 97%, Missing)",-0.41875,-0.446923,-0.693057,0,0,routine_complete,16.1,6.2,6,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); thymus: 6 nTPM (manageable, limit 5); rectum: 3.6 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146410,MTFR2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 29.6943% (minimum 75%, Missing); duodenum: 71.5789% (minimum 75%, Missing); lymph node: 52.3077% (minimum 70%, Missing); rectum: 65.3846% (minimum 70%, Missing); thymus: 53.1250% (minimum 65%, Missing)",-0.11875,-0.176923,-0.453057,0,0,routine_complete,16.1,6.2,6,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); thymus: 6 nTPM (manageable, limit 5); rectum: 3.6 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146410,MTFR2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 29.6943% (minimum 75%, Missing); duodenum: 71.5789% (minimum 75%, Missing); lymph node: 52.3077% (minimum 70%, Missing); rectum: 65.3846% (minimum 70%, Missing); thymus: 53.1250% (minimum 65%, Missing)",-0.11875,-0.176923,-0.453057,0,0,routine_complete,16.1,6.2,6,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); thymus: 6 nTPM (manageable, limit 5); rectum: 3.6 nTPM (protected, limit 3); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146410,MTFR2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 29.6943% (minimum 75%, Missing); duodenum: 71.5789% (minimum 75%, Missing); lymph node: 52.3077% (minimum 70%, Missing); rectum: 65.3846% (minimum 70%, Missing); thymus: 53.1250% (minimum 65%, Missing)",-0.11875,-0.176923,-0.453057,0,0,routine_complete,16.1,6.2,6,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); thymus: 6 nTPM (manageable, limit 5); rectum: 3.6 nTPM (protected, limit 3); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146410,MTFR2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 29.6943% (minimum 75%, Baseline (adaptation disabled)); duodenum: 71.5789% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.3077% (minimum 70%, Baseline (adaptation disabled)); rectum: 65.3846% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.1250% (minimum 65%, Baseline (adaptation disabled))",-0.11875,-0.176923,-0.453057,0,0,routine_complete,16.1,6.2,6,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); thymus: 6 nTPM (manageable, limit 5); rectum: 3.6 nTPM (protected, limit 3); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146410,MTFR2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.5309% (minimum 99%, Missing); amygdala: 94.0476% (minimum 99%, Missing); basal ganglia: 68.6957% (minimum 99%, Missing); bone marrow: 98.7500% (minimum 99%, Uncertain); cerebellum: 96.3415% (minimum 99%, Missing); cerebral cortex: 81.4433% (minimum 99%, Missing); choroid plexus: 98.7500% (minimum 99%, Missing); colon: 96.3415% (minimum 97%, Missing); heart muscle: 97.5309% (minimum 99%, Uncertain); hippocampal formation: 92.9412% (minimum 99%, Missing); hypothalamus: 96.3415% (minimum 99%, Missing); kidney: 97.5309% (minimum 99%, Missing); liver: 94.0476% (minimum 99%, Uncertain); lung: 97.5309% (minimum 99%, Missing); lymph node: 95.1807% (minimum 97%, Uncertain); midbrain: 95.1807% (minimum 99%, Missing); pancreas: 83.1579% (minimum 99%, Missing); pituitary gland: 96.3415% (minimum 99%, Missing); retina: 98.7500% (minimum 99%, Missing); skeletal muscle: 98.7500% (minimum 99%, Uncertain); skin: 88.7640% (minimum 95%, Missing); small intestine: 98.7500% (minimum 99%, Missing); spinal cord: 94.0476% (minimum 99%, Missing)",-0.0623596,-0.0181928,-0.303043,0,1,partial,3.6,0.4,1,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146453,PNLDC1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 68.6957% (minimum 75%, Missing)",0.23764,0.251807,-0.0630435,0,1,partial,3.6,0.4,1,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146453,PNLDC1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 68.6957% (minimum 75%, Missing)",0.23764,0.251807,-0.0630435,0,1,partial,3.6,0.4,1,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146453,PNLDC1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 68.6957% (minimum 75%, Missing)",0.23764,0.251807,-0.0630435,0,1,partial,3.6,0.4,1,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146453,PNLDC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 68.6957% (minimum 75%, Baseline (adaptation disabled))",0.23764,0.251807,-0.0630435,0,1,partial,3.6,0.4,1,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146453,PNLDC1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.8421% (minimum 99%, Missing); amygdala: 97.6127% (minimum 99%, Missing); basal ganglia: 98.1333% (minimum 99%, Missing); bone marrow: 41.1173% (minimum 99%, Missing); cerebellum: 97.8723% (minimum 99%, Missing); cerebral cortex: 93.1646% (minimum 99%, Missing); choroid plexus: 97.3545% (minimum 99%, Missing); colon: 84.7926% (minimum 97%, Missing); duodenum: 86.7925% (minimum 99%, Missing); esophagus: 80.1743% (minimum 97%, Missing); hippocampal formation: 97.6127% (minimum 99%, Missing); hypothalamus: 98.1333% (minimum 99%, Missing); kidney: 97.6127% (minimum 99%, Missing); lymph node: 68.9139% (minimum 97%, Missing); midbrain: 97.6127% (minimum 99%, Missing); pancreas: 98.1333% (minimum 99%, Missing); pituitary gland: 98.6595% (minimum 99%, Missing); rectum: 83.2579% (minimum 97%, Missing); retina: 98.6595% (minimum 99%, Missing); salivary gland: 96.3351% (minimum 97%, Missing); skeletal muscle: 98.3957% (minimum 99%, Missing); skin: 89.9756% (minimum 95%, Missing); small intestine: 86.5882% (minimum 99%, Missing); smooth muscle: 92.4623% (minimum 95%, Enhanced); spinal cord: 98.3957% (minimum 99%, Missing); spleen: 85.1852% (minimum 95%, Missing); stomach: 92.2306% (minimum 97%, Missing); thymus: 57.8616% (minimum 95%, Missing); urinary bladder: 94.6015% (minimum 97%, Missing)",-0.371384,-0.280861,-0.578827,0,13,partial,52.7,16.6,26.8,"bone marrow: 52.7 nTPM (vital, limit 1); thymus: 26.8 nTPM (manageable, limit 5); lymph node: 16.6 nTPM (protected, limit 2); esophagus: 9.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6.6 nTPM (protected, limit 2); spleen: 6.4 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146670,CDCA5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 41.1173% (minimum 75%, Missing); lymph node: 68.9139% (minimum 70%, Missing); thymus: 57.8616% (minimum 65%, Missing)",-0.0713836,-0.0108614,-0.338827,0,13,partial,52.7,16.6,26.8,"bone marrow: 52.7 nTPM (vital, limit 1); thymus: 26.8 nTPM (manageable, limit 5); lymph node: 16.6 nTPM (protected, limit 2); esophagus: 9.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6.6 nTPM (protected, limit 2); spleen: 6.4 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146670,CDCA5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 41.1173% (minimum 75%, Missing); lymph node: 68.9139% (minimum 70%, Missing); thymus: 57.8616% (minimum 65%, Missing)",-0.0713836,-0.0108614,-0.338827,0,13,partial,52.7,16.6,26.8,"bone marrow: 52.7 nTPM (vital, limit 1); thymus: 26.8 nTPM (manageable, limit 5); lymph node: 16.6 nTPM (protected, limit 3); esophagus: 9.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6.6 nTPM (protected, limit 3); spleen: 6.4 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146670,CDCA5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 41.1173% (minimum 75%, Missing); lymph node: 68.9139% (minimum 70%, Missing); thymus: 57.8616% (minimum 65%, Missing)",-0.0713836,-0.0108614,-0.338827,0,13,partial,52.7,16.6,26.8,"bone marrow: 52.7 nTPM (vital, limit 1); thymus: 26.8 nTPM (manageable, limit 5); lymph node: 16.6 nTPM (protected, limit 3); esophagus: 9.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6.6 nTPM (protected, limit 3); spleen: 6.4 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146670,CDCA5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 41.1173% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.9139% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.8616% (minimum 65%, Baseline (adaptation disabled))",-0.0713836,-0.0108614,-0.338827,0,13,partial,52.7,16.6,26.8,"bone marrow: 52.7 nTPM (vital, limit 1); thymus: 26.8 nTPM (manageable, limit 5); lymph node: 16.6 nTPM (protected, limit 3); esophagus: 9.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6.6 nTPM (protected, limit 3); spleen: 6.4 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); smooth muscle: 3 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146670,CDCA5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.1845% (minimum 90%, Approved); adrenal gland: 63.3466% (minimum 99%, Missing); amygdala: 60.2273% (minimum 99%, Missing); basal ganglia: 56.3830% (minimum 99%, Missing); bone marrow: 80.7107% (minimum 98%, Approved); cerebellum: 70.0441% (minimum 99%, Missing); cerebral cortex: 60.2273% (minimum 99%, Missing); choroid plexus: 55.0173% (minimum 99%, Missing); colon: 76.8116% (minimum 97%, Missing); duodenum: 79.1045% (minimum 99%, Missing); esophagus: 65.1639% (minimum 97%, Missing); heart muscle: 66.8067% (minimum 99%, Missing); hippocampal formation: 62.3529% (minimum 99%, Missing); hypothalamus: 62.8458% (minimum 99%, Missing); kidney: 62.1094% (minimum 99%, Missing); liver: 70.6667% (minimum 98%, Approved); lung: 82.3834% (minimum 99%, Missing); lymph node: 75.7143% (minimum 95%, Approved); midbrain: 61.8677% (minimum 99%, Missing); pancreas: 70.9821% (minimum 99%, Missing); parathyroid gland: 70.6667% (minimum 97%, Missing); pituitary gland: 63.3466% (minimum 99%, Missing); rectum: 78.7129% (minimum 97%, Missing); retina: 79.1045% (minimum 99%, Missing); salivary gland: 78.7129% (minimum 97%, Missing); skeletal muscle: 77.9412% (minimum 98%, Approved); skin: 79.5000% (minimum 95%, Missing); small intestine: 79.8995% (minimum 99%, Missing); smooth muscle: 76.4423% (minimum 98%, Approved); spinal cord: 57.4007% (minimum 99%, Missing); spleen: 80.7107% (minimum 90%, Approved); stomach: 72.6027% (minimum 97%, Missing); thymus: 71.6216% (minimum 95%, Missing); thyroid gland: 70.0441% (minimum 95%, Missing); tongue: 71.3004% (minimum 97%, Missing); urinary bladder: 76.0766% (minimum 97%, Missing)",-0.249559,-0.318361,-0.439827,0,4,partial,13,8.5,6.8,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); heart muscle: 7.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 2); parathyroid gland: 6.6 nTPM (protected, limit 2); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 2); lymph node: 5.1 nTPM (protected, limit 4); urinary bladder: 5 nTPM (protected, limit 2); smooth muscle: 4.9 nTPM (vital, limit 2); colon: 4.8 nTPM (protected, limit 2); skeletal muscle: 4.5 nTPM (vital, limit 2); salivary gland: 4.3 nTPM (protected, limit 2); rectum: 4.3 nTPM (protected, limit 2); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 2); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146733,PSPH,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.3466% (minimum 75%, Missing); amygdala: 60.2273% (minimum 75%, Missing); basal ganglia: 56.3830% (minimum 75%, Missing); cerebellum: 70.0441% (minimum 75%, Missing); cerebral cortex: 60.2273% (minimum 75%, Missing); choroid plexus: 55.0173% (minimum 75%, Missing); esophagus: 65.1639% (minimum 70%, Missing); heart muscle: 66.8067% (minimum 75%, Missing); hippocampal formation: 62.3529% (minimum 75%, Missing); hypothalamus: 62.8458% (minimum 75%, Missing); kidney: 62.1094% (minimum 75%, Missing); midbrain: 61.8677% (minimum 75%, Missing); pancreas: 70.9821% (minimum 75%, Missing); pituitary gland: 63.3466% (minimum 75%, Missing); spinal cord: 57.4007% (minimum 75%, Missing)",0.0504405,-0.0483607,-0.199827,0,4,partial,13,8.5,6.8,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); heart muscle: 7.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 2); parathyroid gland: 6.6 nTPM (protected, limit 2); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 2); lymph node: 5.1 nTPM (protected, limit 4); urinary bladder: 5 nTPM (protected, limit 2); smooth muscle: 4.9 nTPM (vital, limit 2); colon: 4.8 nTPM (protected, limit 2); skeletal muscle: 4.5 nTPM (vital, limit 2); salivary gland: 4.3 nTPM (protected, limit 2); rectum: 4.3 nTPM (protected, limit 2); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 2); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146733,PSPH,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.3466% (minimum 75%, Missing); amygdala: 60.2273% (minimum 75%, Missing); basal ganglia: 56.3830% (minimum 75%, Missing); cerebellum: 70.0441% (minimum 75%, Missing); cerebral cortex: 60.2273% (minimum 75%, Missing); choroid plexus: 55.0173% (minimum 75%, Missing); esophagus: 65.1639% (minimum 70%, Missing); heart muscle: 66.8067% (minimum 75%, Missing); hippocampal formation: 62.3529% (minimum 75%, Missing); hypothalamus: 62.8458% (minimum 75%, Missing); kidney: 62.1094% (minimum 75%, Missing); midbrain: 61.8677% (minimum 75%, Missing); pancreas: 70.9821% (minimum 75%, Missing); pituitary gland: 63.3466% (minimum 75%, Missing); spinal cord: 57.4007% (minimum 75%, Missing)",0.0504405,-0.0483607,-0.199827,0,4,partial,13,8.5,6.8,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); heart muscle: 7.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 2); parathyroid gland: 6.6 nTPM (protected, limit 3); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 3); lymph node: 5.1 nTPM (protected, limit 4); urinary bladder: 5 nTPM (protected, limit 3); smooth muscle: 4.9 nTPM (vital, limit 2); colon: 4.8 nTPM (protected, limit 3); skeletal muscle: 4.5 nTPM (vital, limit 2); salivary gland: 4.3 nTPM (protected, limit 3); rectum: 4.3 nTPM (protected, limit 3); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 2); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146733,PSPH,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.3466% (minimum 75%, Missing); amygdala: 60.2273% (minimum 75%, Missing); basal ganglia: 56.3830% (minimum 75%, Missing); cerebellum: 70.0441% (minimum 75%, Missing); cerebral cortex: 60.2273% (minimum 75%, Missing); choroid plexus: 55.0173% (minimum 75%, Missing); esophagus: 65.1639% (minimum 70%, Missing); heart muscle: 66.8067% (minimum 75%, Missing); hippocampal formation: 62.3529% (minimum 75%, Missing); hypothalamus: 62.8458% (minimum 75%, Missing); kidney: 62.1094% (minimum 75%, Missing); midbrain: 61.8677% (minimum 75%, Missing); pancreas: 70.9821% (minimum 75%, Missing); pituitary gland: 63.3466% (minimum 75%, Missing); spinal cord: 57.4007% (minimum 75%, Missing)",0.0504405,-0.0483607,-0.199827,0,4,partial,13,8.5,6.8,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); heart muscle: 7.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 2); parathyroid gland: 6.6 nTPM (protected, limit 3); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 3); lymph node: 5.1 nTPM (protected, limit 4); urinary bladder: 5 nTPM (protected, limit 3); smooth muscle: 4.9 nTPM (vital, limit 2); colon: 4.8 nTPM (protected, limit 3); skeletal muscle: 4.5 nTPM (vital, limit 2); salivary gland: 4.3 nTPM (protected, limit 3); rectum: 4.3 nTPM (protected, limit 3); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 2); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146733,PSPH,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.3466% (minimum 75%, Baseline (adaptation disabled)); amygdala: 60.2273% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.3830% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.0441% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.2273% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 55.0173% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.1639% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.8067% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 62.3529% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.8458% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.1094% (minimum 75%, Baseline (adaptation disabled)); liver: 70.6667% (minimum 75%, Baseline (adaptation disabled)); midbrain: 61.8677% (minimum 75%, Baseline (adaptation disabled)); pancreas: 70.9821% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 63.3466% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.4007% (minimum 75%, Baseline (adaptation disabled))",0.0504405,-0.0483607,-0.199827,0,4,partial,13,8.5,6.8,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); heart muscle: 7.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 3); lymph node: 5.1 nTPM (protected, limit 3); urinary bladder: 5 nTPM (protected, limit 3); smooth muscle: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); skeletal muscle: 4.5 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 3); rectum: 4.3 nTPM (protected, limit 3); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146733,PSPH,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146839,ZAN,admission_only,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146839,ZAN,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146839,ZAN,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146839,ZAN,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146839,ZAN,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.2649% (minimum 95%, Missing); adrenal gland: 59.5652% (minimum 99%, Missing); amygdala: 81.0651% (minimum 99%, Missing); basal ganglia: 75.4821% (minimum 99%, Missing); bone marrow: 71.7277% (minimum 99%, Missing); cerebellum: 91.3333% (minimum 99%, Missing); cerebral cortex: 77.4011% (minimum 99%, Missing); choroid plexus: 83.2827% (minimum 99%, Missing); colon: 62.2727% (minimum 97%, Missing); duodenum: 61.2975% (minimum 99%, Missing); esophagus: 75.4821% (minimum 97%, Missing); heart muscle: 47.9860% (minimum 99%, Missing); hippocampal formation: 74.6594% (minimum 99%, Missing); hypothalamus: 79.4203% (minimum 99%, Missing); kidney: 50.9294% (minimum 99%, Missing); liver: 34.5088% (minimum 99%, Missing); lung: 47.9021% (minimum 99%, Missing); lymph node: 58.1741% (minimum 97%, Missing); midbrain: 66.9927% (minimum 99%, Missing); pancreas: 65.5502% (minimum 99%, Missing); parathyroid gland: 91.9463% (minimum 97%, Missing); pituitary gland: 84.3077% (minimum 99%, Missing); rectum: 77.1831% (minimum 97%, Missing); retina: 90.4290% (minimum 99%, Missing); salivary gland: 61.7117% (minimum 97%, Missing); skeletal muscle: 24.4861% (minimum 99%, Missing); skin: 75.4821% (minimum 95%, Missing); small intestine: 62.1315% (minimum 99%, Missing); smooth muscle: 73.0667% (minimum 99%, Missing); spinal cord: 53.6204% (minimum 99%, Missing); spleen: 50.2752% (minimum 95%, Missing); stomach: 69.1919% (minimum 97%, Missing); thymus: 81.3056% (minimum 95%, Missing); thyroid gland: 72.1053% (minimum 95%, Missing); tongue: 57.6842% (minimum 97%, Missing); urinary bladder: 63.1336% (minimum 97%, Missing)",-0.507351,-0.393158,-0.745139,0,80,unavailable,84.5,20.1,34.5,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (manageable, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); spleen: 27.1 nTPM (manageable, limit 5); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 2); lymph node: 19.7 nTPM (protected, limit 2); adrenal gland: 18.6 nTPM (vital, limit 1); duodenum: 17.3 nTPM (vital, limit 1); salivary gland: 17 nTPM (protected, limit 2); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 2); urinary bladder: 16 nTPM (protected, limit 2); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 2); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); skin: 8.9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 2); rectum: 8.1 nTPM (protected, limit 2); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146859,TMEM140,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.2649% (minimum 65%, Missing); adrenal gland: 59.5652% (minimum 75%, Missing); bone marrow: 71.7277% (minimum 75%, Missing); colon: 62.2727% (minimum 70%, Missing); duodenum: 61.2975% (minimum 75%, Missing); heart muscle: 47.9860% (minimum 75%, Missing); hippocampal formation: 74.6594% (minimum 75%, Missing); kidney: 50.9294% (minimum 75%, Missing); liver: 34.5088% (minimum 75%, Missing); lung: 47.9021% (minimum 75%, Missing); lymph node: 58.1741% (minimum 70%, Missing); midbrain: 66.9927% (minimum 75%, Missing); pancreas: 65.5502% (minimum 75%, Missing); salivary gland: 61.7117% (minimum 70%, Missing); skeletal muscle: 24.4861% (minimum 75%, Missing); small intestine: 62.1315% (minimum 75%, Missing); smooth muscle: 73.0667% (minimum 75%, Missing); spinal cord: 53.6204% (minimum 75%, Missing); spleen: 50.2752% (minimum 65%, Missing); stomach: 69.1919% (minimum 70%, Missing); tongue: 57.6842% (minimum 70%, Missing); urinary bladder: 63.1336% (minimum 70%, Missing)",-0.207351,-0.123158,-0.505139,0,80,unavailable,84.5,20.1,34.5,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (manageable, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); spleen: 27.1 nTPM (manageable, limit 5); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 2); lymph node: 19.7 nTPM (protected, limit 2); adrenal gland: 18.6 nTPM (vital, limit 1); duodenum: 17.3 nTPM (vital, limit 1); salivary gland: 17 nTPM (protected, limit 2); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 2); urinary bladder: 16 nTPM (protected, limit 2); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 2); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); skin: 8.9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 2); rectum: 8.1 nTPM (protected, limit 2); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146859,TMEM140,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.2649% (minimum 65%, Missing); adrenal gland: 59.5652% (minimum 75%, Missing); bone marrow: 71.7277% (minimum 75%, Missing); colon: 62.2727% (minimum 70%, Missing); duodenum: 61.2975% (minimum 75%, Missing); heart muscle: 47.9860% (minimum 75%, Missing); hippocampal formation: 74.6594% (minimum 75%, Missing); kidney: 50.9294% (minimum 75%, Missing); liver: 34.5088% (minimum 75%, Missing); lung: 47.9021% (minimum 75%, Missing); lymph node: 58.1741% (minimum 70%, Missing); midbrain: 66.9927% (minimum 75%, Missing); pancreas: 65.5502% (minimum 75%, Missing); salivary gland: 61.7117% (minimum 70%, Missing); skeletal muscle: 24.4861% (minimum 75%, Missing); small intestine: 62.1315% (minimum 75%, Missing); smooth muscle: 73.0667% (minimum 75%, Missing); spinal cord: 53.6204% (minimum 75%, Missing); spleen: 50.2752% (minimum 65%, Missing); stomach: 69.1919% (minimum 70%, Missing); tongue: 57.6842% (minimum 70%, Missing); urinary bladder: 63.1336% (minimum 70%, Missing)",-0.207351,-0.123158,-0.505139,0,80,unavailable,84.5,20.1,34.5,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (manageable, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); spleen: 27.1 nTPM (manageable, limit 5); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 3); lymph node: 19.7 nTPM (protected, limit 3); adrenal gland: 18.6 nTPM (vital, limit 1); duodenum: 17.3 nTPM (vital, limit 1); salivary gland: 17 nTPM (protected, limit 3); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 3); urinary bladder: 16 nTPM (protected, limit 3); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 3); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); skin: 8.9 nTPM (manageable, limit 5); basal ganglia: 8.9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 3); rectum: 8.1 nTPM (protected, limit 3); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146859,TMEM140,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.2649% (minimum 65%, Missing); adrenal gland: 59.5652% (minimum 75%, Missing); bone marrow: 71.7277% (minimum 75%, Missing); colon: 62.2727% (minimum 70%, Missing); duodenum: 61.2975% (minimum 75%, Missing); heart muscle: 47.9860% (minimum 75%, Missing); hippocampal formation: 74.6594% (minimum 75%, Missing); kidney: 50.9294% (minimum 75%, Missing); liver: 34.5088% (minimum 75%, Missing); lung: 47.9021% (minimum 75%, Missing); lymph node: 58.1741% (minimum 70%, Missing); midbrain: 66.9927% (minimum 75%, Missing); pancreas: 65.5502% (minimum 75%, Missing); salivary gland: 61.7117% (minimum 70%, Missing); skeletal muscle: 24.4861% (minimum 75%, Missing); small intestine: 62.1315% (minimum 75%, Missing); smooth muscle: 73.0667% (minimum 75%, Missing); spinal cord: 53.6204% (minimum 75%, Missing); spleen: 50.2752% (minimum 65%, Missing); stomach: 69.1919% (minimum 70%, Missing); tongue: 57.6842% (minimum 70%, Missing); urinary bladder: 63.1336% (minimum 70%, Missing)",-0.207351,-0.123158,-0.505139,0,80,unavailable,84.5,20.1,34.5,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (manageable, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); spleen: 27.1 nTPM (manageable, limit 5); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 3); lymph node: 19.7 nTPM (protected, limit 3); adrenal gland: 18.6 nTPM (vital, limit 1); duodenum: 17.3 nTPM (vital, limit 1); salivary gland: 17 nTPM (protected, limit 3); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 3); urinary bladder: 16 nTPM (protected, limit 3); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 3); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); skin: 8.9 nTPM (manageable, limit 5); basal ganglia: 8.9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 3); rectum: 8.1 nTPM (protected, limit 3); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146859,TMEM140,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.2649% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 59.5652% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 71.7277% (minimum 75%, Baseline (adaptation disabled)); colon: 62.2727% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.2975% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 47.9860% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.6594% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.9294% (minimum 75%, Baseline (adaptation disabled)); liver: 34.5088% (minimum 75%, Baseline (adaptation disabled)); lung: 47.9021% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.1741% (minimum 70%, Baseline (adaptation disabled)); midbrain: 66.9927% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.5502% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.7117% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 24.4861% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.1315% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.0667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.6204% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.2752% (minimum 65%, Baseline (adaptation disabled)); stomach: 69.1919% (minimum 70%, Baseline (adaptation disabled)); tongue: 57.6842% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.1336% (minimum 70%, Baseline (adaptation disabled))",-0.207351,-0.123158,-0.505139,0,80,unavailable,84.5,20.1,34.5,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (manageable, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); spleen: 27.1 nTPM (manageable, limit 5); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 3); lymph node: 19.7 nTPM (protected, limit 3); adrenal gland: 18.6 nTPM (vital, limit 1); duodenum: 17.3 nTPM (vital, limit 1); salivary gland: 17 nTPM (protected, limit 3); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 3); urinary bladder: 16 nTPM (protected, limit 3); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 3); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); skin: 8.9 nTPM (manageable, limit 5); basal ganglia: 8.9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 3); rectum: 8.1 nTPM (protected, limit 3); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146859,TMEM140,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 90%, Approved); adrenal gland: 85.7143% (minimum 99%, Missing); amygdala: 85.7143% (minimum 99%, Missing); basal ganglia: 84.7059% (minimum 99%, Missing); bone marrow: 37.4026% (minimum 99%, Missing); cerebellum: 85.2071% (minimum 99%, Missing); cerebral cortex: 81.3559% (minimum 99%, Missing); choroid plexus: 91.7197% (minimum 99%, Missing); colon: 68.2464% (minimum 97%, Missing); duodenum: 77.0053% (minimum 99%, Missing); esophagus: 68.2464% (minimum 97%, Missing); heart muscle: 83.7209% (minimum 99%, Missing); hippocampal formation: 84.7059% (minimum 99%, Missing); hypothalamus: 87.8049% (minimum 99%, Missing); kidney: 85.2071% (minimum 99%, Missing); liver: 78.2609% (minimum 99%, Missing); lung: 82.7586% (minimum 99%, Missing); lymph node: 54.3396% (minimum 97%, Missing); midbrain: 86.2275% (minimum 99%, Missing); pancreas: 87.2727% (minimum 99%, Missing); parathyroid gland: 76.1905% (minimum 97%, Missing); pituitary gland: 80.8989% (minimum 99%, Missing); rectum: 66.0550% (minimum 97%, Missing); retina: 84.2105% (minimum 99%, Missing); salivary gland: 80.8989% (minimum 97%, Missing); skeletal muscle: 81.3559% (minimum 99%, Missing); skin: 68.5714% (minimum 95%, Missing); small intestine: 72.0000% (minimum 99%, Missing); smooth muscle: 75.3927% (minimum 99%, Missing); spinal cord: 82.7586% (minimum 99%, Missing); spleen: 76.5957% (minimum 95%, Missing); stomach: 72.7273% (minimum 97%, Missing); thymus: 34.6154% (minimum 95%, Missing); thyroid gland: 82.2857% (minimum 95%, Missing); tongue: 78.6885% (minimum 97%, Missing); urinary bladder: 78.6885% (minimum 97%, Missing)",-0.603846,-0.426604,-0.615974,0,1,partial,24.1,12.1,27.2,"thymus: 27.2 nTPM (manageable, limit 5); bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); esophagus: 6.7 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146918,NCAPG2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.4026% (minimum 75%, Missing); colon: 68.2464% (minimum 70%, Missing); esophagus: 68.2464% (minimum 70%, Missing); lymph node: 54.3396% (minimum 70%, Missing); rectum: 66.0550% (minimum 70%, Missing); small intestine: 72.0000% (minimum 75%, Missing); thymus: 34.6154% (minimum 65%, Missing)",-0.303846,-0.156604,-0.375974,0,1,partial,24.1,12.1,27.2,"thymus: 27.2 nTPM (manageable, limit 5); bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); esophagus: 6.7 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146918,NCAPG2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.4026% (minimum 75%, Missing); colon: 68.2464% (minimum 70%, Missing); esophagus: 68.2464% (minimum 70%, Missing); lymph node: 54.3396% (minimum 70%, Missing); rectum: 66.0550% (minimum 70%, Missing); small intestine: 72.0000% (minimum 75%, Missing); thymus: 34.6154% (minimum 65%, Missing)",-0.303846,-0.156604,-0.375974,0,1,partial,24.1,12.1,27.2,"thymus: 27.2 nTPM (manageable, limit 5); bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); esophagus: 6.7 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); pituitary gland: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146918,NCAPG2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.4026% (minimum 75%, Missing); colon: 68.2464% (minimum 70%, Missing); esophagus: 68.2464% (minimum 70%, Missing); lymph node: 54.3396% (minimum 70%, Missing); rectum: 66.0550% (minimum 70%, Missing); small intestine: 72.0000% (minimum 75%, Missing); thymus: 34.6154% (minimum 65%, Missing)",-0.303846,-0.156604,-0.375974,0,1,partial,24.1,12.1,27.2,"thymus: 27.2 nTPM (manageable, limit 5); bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); esophagus: 6.7 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); pituitary gland: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146918,NCAPG2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.4026% (minimum 75%, Baseline (adaptation disabled)); colon: 68.2464% (minimum 70%, Baseline (adaptation disabled)); esophagus: 68.2464% (minimum 70%, Baseline (adaptation disabled)); lymph node: 54.3396% (minimum 70%, Baseline (adaptation disabled)); rectum: 66.0550% (minimum 70%, Baseline (adaptation disabled)); small intestine: 72.0000% (minimum 75%, Baseline (adaptation disabled)); thymus: 34.6154% (minimum 65%, Baseline (adaptation disabled))",-0.303846,-0.156604,-0.375974,0,1,partial,24.1,12.1,27.2,"thymus: 27.2 nTPM (manageable, limit 5); bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); esophagus: 6.7 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); pituitary gland: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000146918,NCAPG2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147081,AKAP4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147081,AKAP4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147081,AKAP4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147081,AKAP4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147081,AKAP4,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.0000% (minimum 99%, Missing); amygdala: 93.4426% (minimum 99%, Missing); basal ganglia: 93.4426% (minimum 99%, Missing); cerebellum: 96.6102% (minimum 99%, Missing); cerebral cortex: 93.4426% (minimum 99%, Missing); choroid plexus: 93.4426% (minimum 99%, Missing); heart muscle: 98.2759% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 89.0625% (minimum 99%, Missing); kidney: 91.9355% (minimum 99%, Missing); liver: 93.4426% (minimum 99%, Missing); lung: 95.0000% (minimum 99%, Missing); midbrain: 82.6087% (minimum 99%, Missing); pancreas: 93.4426% (minimum 99%, Missing); pituitary gland: 89.0625% (minimum 99%, Missing); retina: 91.9355% (minimum 99%, Missing); skeletal muscle: 93.4426% (minimum 99%, Missing); small intestine: 98.2759% (minimum 99%, Missing); spinal cord: 69.5122% (minimum 99%, Missing); stomach: 93.4426% (minimum 97%, Missing)",1.11022e-16,-0.0355738,-0.294878,0,80,unavailable,2.5,0.4,0.3,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147082,CCNB3,admission_only,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 69.5122% (minimum 75%, Missing)",0.3,0.234426,-0.054878,0,80,unavailable,2.5,0.4,0.3,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147082,CCNB3,selectivity_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 69.5122% (minimum 75%, Missing)",0.3,0.234426,-0.054878,0,80,unavailable,2.5,0.4,0.3,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147082,CCNB3,grid_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 69.5122% (minimum 75%, Missing)",0.3,0.234426,-0.054878,0,80,unavailable,2.5,0.4,0.3,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147082,CCNB3,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 69.5122% (minimum 75%, Baseline (adaptation disabled))",0.3,0.234426,-0.054878,0,80,unavailable,2.5,0.4,0.3,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147082,CCNB3,current_fixed,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.1220% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 70.9091% (minimum 99%, Missing); bone marrow: 97.5000% (minimum 99%, Missing); cerebellum: 84.7826% (minimum 99%, Missing); cerebral cortex: 73.5849% (minimum 99%, Missing); choroid plexus: 97.5000% (minimum 99%, Missing); colon: 92.8571% (minimum 97%, Missing); duodenum: 97.5000% (minimum 99%, Missing); heart muscle: 95.1220% (minimum 99%, Missing); hippocampal formation: 79.5918% (minimum 99%, Missing); hypothalamus: 76.4706% (minimum 99%, Missing); kidney: 95.1220% (minimum 99%, Missing); liver: 97.5000% (minimum 99%, Missing); lung: 97.5000% (minimum 99%, Missing); midbrain: 72.2222% (minimum 99%, Missing); pancreas: 97.5000% (minimum 99%, Missing); pituitary gland: 95.1220% (minimum 99%, Missing); retina: 6.5109% (minimum 99%, Missing); salivary gland: 95.1220% (minimum 97%, Missing); skeletal muscle: 97.5000% (minimum 99%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 90.6977% (minimum 99%, Missing); spinal cord: 78.0000% (minimum 99%, Missing); urinary bladder: 95.1220% (minimum 97%, Missing)",-0.0214286,-0.0414286,-0.924891,0,80,unavailable,56,0.3,0.3,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147127,RAB41,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 70.9091% (minimum 75%, Missing); cerebral cortex: 73.5849% (minimum 75%, Missing); midbrain: 72.2222% (minimum 75%, Missing); retina: 6.5109% (minimum 75%, Missing)",0.278571,0.228571,-0.684891,0,80,unavailable,56,0.3,0.3,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147127,RAB41,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 70.9091% (minimum 75%, Missing); cerebral cortex: 73.5849% (minimum 75%, Missing); midbrain: 72.2222% (minimum 75%, Missing); retina: 6.5109% (minimum 75%, Missing)",0.278571,0.228571,-0.684891,0,80,unavailable,56,0.3,0.3,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147127,RAB41,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 70.9091% (minimum 75%, Missing); cerebral cortex: 73.5849% (minimum 75%, Missing); midbrain: 72.2222% (minimum 75%, Missing); retina: 6.5109% (minimum 75%, Missing)",0.278571,0.228571,-0.684891,0,80,unavailable,56,0.3,0.3,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147127,RAB41,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 70.9091% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.5849% (minimum 75%, Baseline (adaptation disabled)); midbrain: 72.2222% (minimum 75%, Baseline (adaptation disabled)); retina: 6.5109% (minimum 75%, Baseline (adaptation disabled))",0.278571,0.228571,-0.684891,0,80,unavailable,56,0.3,0.3,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147127,RAB41,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.1198% (minimum 99%, Missing); amygdala: 80.0885% (minimum 99%, Missing); basal ganglia: 81.9005% (minimum 99%, Missing); bone marrow: 83.6028% (minimum 95%, Enhanced); cerebellum: 76.3713% (minimum 99%, Missing); cerebral cortex: 66.4220% (minimum 99%, Missing); choroid plexus: 96.7914% (minimum 99%, Missing); colon: 91.1839% (minimum 97%, Missing); duodenum: 92.3469% (minimum 99%, Missing); heart muscle: 90.9548% (minimum 99%, Missing); hippocampal formation: 81.5315% (minimum 99%, Missing); hypothalamus: 80.0885% (minimum 99%, Missing); kidney: 87.8641% (minimum 99%, Missing); lung: 95.5145% (minimum 99%, Missing); midbrain: 83.7963% (minimum 99%, Missing); pancreas: 88.5086% (minimum 95%, Enhanced); pituitary gland: 77.3504% (minimum 99%, Missing); rectum: 95.5145% (minimum 97%, Missing); retina: 86.8106% (minimum 99%, Missing); small intestine: 88.9435% (minimum 99%, Missing); smooth muscle: 92.1120% (minimum 95%, Enhanced); spinal cord: 83.7963% (minimum 99%, Missing); thymus: 69.4818% (minimum 95%, Missing); tongue: 96.0212% (minimum 97%, Missing); urinary bladder: 92.5831% (minimum 97%, Missing)",-0.255182,-0.0581612,-0.32578,0,6,partial,18.3,4,15.9,"cerebral cortex: 18.3 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 6); midbrain: 7 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147180,ZNF711,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.1198% (minimum 75%, Missing); cerebral cortex: 66.4220% (minimum 75%, Missing)",0.0448177,0.211839,-0.0857798,0,6,partial,18.3,4,15.9,"cerebral cortex: 18.3 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 6); midbrain: 7 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147180,ZNF711,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.1198% (minimum 75%, Missing); cerebral cortex: 66.4220% (minimum 75%, Missing)",0.0448177,0.211839,-0.0857798,0,6,partial,18.3,4,15.9,"cerebral cortex: 18.3 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 6); midbrain: 7 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147180,ZNF711,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.1198% (minimum 75%, Missing); cerebral cortex: 66.4220% (minimum 75%, Missing)",0.0448177,0.211839,-0.0857798,0,6,partial,18.3,4,15.9,"cerebral cortex: 18.3 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 6); midbrain: 7 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147180,ZNF711,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.1198% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.4220% (minimum 75%, Baseline (adaptation disabled))",0.0448177,0.200498,-0.0857798,0,6,partial,18.3,4,15.9,"cerebral cortex: 18.3 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 3); heart muscle: 3.6 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 3); smooth muscle: 3.1 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147180,ZNF711,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147183,CPXCR1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147183,CPXCR1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147183,CPXCR1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147183,CPXCR1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147183,CPXCR1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"bone marrow: 93.5108% (minimum 98%, Approved); duodenum: 98.9437% (minimum 99%, Missing); lung: 92.1311% (minimum 98%, Approved); small intestine: 95.0931% (minimum 98%, Approved)",0.05,0.03,-0.0586885,0,2,partial,4.8,1,0.6,"lung: 4.8 nTPM (vital, limit 2); bone marrow: 3.9 nTPM (vital, limit 2); small intestine: 2.9 nTPM (vital, limit 2)",duodenum / glandular cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000147206,NXF3,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.221311,0,2,partial,4.8,1,0.6,"lung: 4.8 nTPM (vital, limit 2); bone marrow: 3.9 nTPM (vital, limit 2); small intestine: 2.9 nTPM (vital, limit 2)",duodenum / glandular cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000147206,NXF3,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.221311,0,2,partial,4.8,1,0.6,"lung: 4.8 nTPM (vital, limit 2); bone marrow: 3.9 nTPM (vital, limit 2); small intestine: 2.9 nTPM (vital, limit 2)",duodenum / glandular cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000147206,NXF3,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.221311,0,2,partial,4.8,1,0.6,"lung: 4.8 nTPM (vital, limit 2); bone marrow: 3.9 nTPM (vital, limit 2); small intestine: 2.9 nTPM (vital, limit 2)",duodenum / glandular cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000147206,NXF3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.339437,0.282517,0.171311,0,2,partial,4.8,1,0.6,"lung: 4.8 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000147206,NXF3,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5862% (minimum 95%, Missing); adrenal gland: 62.8866% (minimum 99%, Missing); amygdala: 62.8866% (minimum 99%, Missing); basal ganglia: 61.0000% (minimum 99%, Missing); bone marrow: 31.7708% (minimum 99%, Missing); cerebellum: 55.9633% (minimum 99%, Missing); cerebral cortex: 58.0952% (minimum 99%, Missing); choroid plexus: 67.7778% (minimum 99%, Missing); colon: 55.9633% (minimum 97%, Missing); duodenum: 61.6162% (minimum 99%, Missing); esophagus: 57.0093% (minimum 97%, Missing); heart muscle: 59.8039% (minimum 99%, Missing); hippocampal formation: 61.6162% (minimum 99%, Missing); hypothalamus: 64.2105% (minimum 99%, Missing); kidney: 59.2233% (minimum 99%, Missing); liver: 61.6162% (minimum 99%, Missing); lung: 58.6538% (minimum 99%, Missing); lymph node: 53.9823% (minimum 97%, Missing); midbrain: 61.0000% (minimum 99%, Missing); pancreas: 54.9550% (minimum 99%, Missing); parathyroid gland: 60.3960% (minimum 97%, Missing); pituitary gland: 62.2449% (minimum 99%, Missing); rectum: 67.0330% (minimum 97%, Missing); retina: 58.0952% (minimum 99%, Missing); salivary gland: 51.6949% (minimum 97%, Missing); skeletal muscle: 39.1026% (minimum 99%, Missing); skin: 54.9550% (minimum 95%, Missing); small intestine: 57.5472% (minimum 99%, Missing); smooth muscle: 68.5393% (minimum 99%, Missing); spinal cord: 57.0093% (minimum 99%, Missing); spleen: 55.4545% (minimum 95%, Missing); stomach: 57.5472% (minimum 97%, Missing); thymus: 27.3543% (minimum 95%, Missing); thyroid gland: 57.5472% (minimum 95%, Missing); tongue: 62.2449% (minimum 97%, Missing); urinary bladder: 53.9823% (minimum 97%, Missing)",-0.676457,-0.453051,-0.672292,0,4,partial,13.1,5.7,16.2,"thymus: 16.2 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); salivary gland: 5.7 nTPM (protected, limit 2); adipose tissue: 5.5 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 2); urinary bladder: 5.2 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); spinal cord: 4.6 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147316,MCPH1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5862% (minimum 65%, Missing); adrenal gland: 62.8866% (minimum 75%, Missing); amygdala: 62.8866% (minimum 75%, Missing); basal ganglia: 61.0000% (minimum 75%, Missing); bone marrow: 31.7708% (minimum 75%, Missing); cerebellum: 55.9633% (minimum 75%, Missing); cerebral cortex: 58.0952% (minimum 75%, Missing); choroid plexus: 67.7778% (minimum 75%, Missing); colon: 55.9633% (minimum 70%, Missing); duodenum: 61.6162% (minimum 75%, Missing); esophagus: 57.0093% (minimum 70%, Missing); heart muscle: 59.8039% (minimum 75%, Missing); hippocampal formation: 61.6162% (minimum 75%, Missing); hypothalamus: 64.2105% (minimum 75%, Missing); kidney: 59.2233% (minimum 75%, Missing); liver: 61.6162% (minimum 75%, Missing); lung: 58.6538% (minimum 75%, Missing); lymph node: 53.9823% (minimum 70%, Missing); midbrain: 61.0000% (minimum 75%, Missing); pancreas: 54.9550% (minimum 75%, Missing); parathyroid gland: 60.3960% (minimum 70%, Missing); pituitary gland: 62.2449% (minimum 75%, Missing); rectum: 67.0330% (minimum 70%, Missing); retina: 58.0952% (minimum 75%, Missing); salivary gland: 51.6949% (minimum 70%, Missing); skeletal muscle: 39.1026% (minimum 75%, Missing); skin: 54.9550% (minimum 65%, Missing); small intestine: 57.5472% (minimum 75%, Missing); smooth muscle: 68.5393% (minimum 75%, Missing); spinal cord: 57.0093% (minimum 75%, Missing); spleen: 55.4545% (minimum 65%, Missing); stomach: 57.5472% (minimum 70%, Missing); thymus: 27.3543% (minimum 65%, Missing); thyroid gland: 57.5472% (minimum 65%, Missing); tongue: 62.2449% (minimum 70%, Missing); urinary bladder: 53.9823% (minimum 70%, Missing)",-0.376457,-0.183051,-0.432292,0,4,partial,13.1,5.7,16.2,"thymus: 16.2 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); salivary gland: 5.7 nTPM (protected, limit 2); adipose tissue: 5.5 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 2); urinary bladder: 5.2 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); spinal cord: 4.6 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147316,MCPH1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5862% (minimum 65%, Missing); adrenal gland: 62.8866% (minimum 75%, Missing); amygdala: 62.8866% (minimum 75%, Missing); basal ganglia: 61.0000% (minimum 75%, Missing); bone marrow: 31.7708% (minimum 75%, Missing); cerebellum: 55.9633% (minimum 75%, Missing); cerebral cortex: 58.0952% (minimum 75%, Missing); choroid plexus: 67.7778% (minimum 75%, Missing); colon: 55.9633% (minimum 70%, Missing); duodenum: 61.6162% (minimum 75%, Missing); esophagus: 57.0093% (minimum 70%, Missing); heart muscle: 59.8039% (minimum 75%, Missing); hippocampal formation: 61.6162% (minimum 75%, Missing); hypothalamus: 64.2105% (minimum 75%, Missing); kidney: 59.2233% (minimum 75%, Missing); liver: 61.6162% (minimum 75%, Missing); lung: 58.6538% (minimum 75%, Missing); lymph node: 53.9823% (minimum 70%, Missing); midbrain: 61.0000% (minimum 75%, Missing); pancreas: 54.9550% (minimum 75%, Missing); parathyroid gland: 60.3960% (minimum 70%, Missing); pituitary gland: 62.2449% (minimum 75%, Missing); rectum: 67.0330% (minimum 70%, Missing); retina: 58.0952% (minimum 75%, Missing); salivary gland: 51.6949% (minimum 70%, Missing); skeletal muscle: 39.1026% (minimum 75%, Missing); skin: 54.9550% (minimum 65%, Missing); small intestine: 57.5472% (minimum 75%, Missing); smooth muscle: 68.5393% (minimum 75%, Missing); spinal cord: 57.0093% (minimum 75%, Missing); spleen: 55.4545% (minimum 65%, Missing); stomach: 57.5472% (minimum 70%, Missing); thymus: 27.3543% (minimum 65%, Missing); thyroid gland: 57.5472% (minimum 65%, Missing); tongue: 62.2449% (minimum 70%, Missing); urinary bladder: 53.9823% (minimum 70%, Missing)",-0.376457,-0.183051,-0.432292,0,4,partial,13.1,5.7,16.2,"thymus: 16.2 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); salivary gland: 5.7 nTPM (protected, limit 3); adipose tissue: 5.5 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 3); urinary bladder: 5.2 nTPM (protected, limit 3); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); spinal cord: 4.6 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147316,MCPH1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5862% (minimum 65%, Missing); adrenal gland: 62.8866% (minimum 75%, Missing); amygdala: 62.8866% (minimum 75%, Missing); basal ganglia: 61.0000% (minimum 75%, Missing); bone marrow: 31.7708% (minimum 75%, Missing); cerebellum: 55.9633% (minimum 75%, Missing); cerebral cortex: 58.0952% (minimum 75%, Missing); choroid plexus: 67.7778% (minimum 75%, Missing); colon: 55.9633% (minimum 70%, Missing); duodenum: 61.6162% (minimum 75%, Missing); esophagus: 57.0093% (minimum 70%, Missing); heart muscle: 59.8039% (minimum 75%, Missing); hippocampal formation: 61.6162% (minimum 75%, Missing); hypothalamus: 64.2105% (minimum 75%, Missing); kidney: 59.2233% (minimum 75%, Missing); liver: 61.6162% (minimum 75%, Missing); lung: 58.6538% (minimum 75%, Missing); lymph node: 53.9823% (minimum 70%, Missing); midbrain: 61.0000% (minimum 75%, Missing); pancreas: 54.9550% (minimum 75%, Missing); parathyroid gland: 60.3960% (minimum 70%, Missing); pituitary gland: 62.2449% (minimum 75%, Missing); rectum: 67.0330% (minimum 70%, Missing); retina: 58.0952% (minimum 75%, Missing); salivary gland: 51.6949% (minimum 70%, Missing); skeletal muscle: 39.1026% (minimum 75%, Missing); skin: 54.9550% (minimum 65%, Missing); small intestine: 57.5472% (minimum 75%, Missing); smooth muscle: 68.5393% (minimum 75%, Missing); spinal cord: 57.0093% (minimum 75%, Missing); spleen: 55.4545% (minimum 65%, Missing); stomach: 57.5472% (minimum 70%, Missing); thymus: 27.3543% (minimum 65%, Missing); thyroid gland: 57.5472% (minimum 65%, Missing); tongue: 62.2449% (minimum 70%, Missing); urinary bladder: 53.9823% (minimum 70%, Missing)",-0.376457,-0.183051,-0.432292,0,4,partial,13.1,5.7,16.2,"thymus: 16.2 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); salivary gland: 5.7 nTPM (protected, limit 3); adipose tissue: 5.5 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 3); urinary bladder: 5.2 nTPM (protected, limit 3); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); spinal cord: 4.6 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147316,MCPH1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5862% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.8866% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.8866% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 31.7708% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.9633% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.0952% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.7778% (minimum 75%, Baseline (adaptation disabled)); colon: 55.9633% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.6162% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.0093% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.8039% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.6162% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.2105% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.2233% (minimum 75%, Baseline (adaptation disabled)); liver: 61.6162% (minimum 75%, Baseline (adaptation disabled)); lung: 58.6538% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.9823% (minimum 70%, Baseline (adaptation disabled)); midbrain: 61.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.9550% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.3960% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.2449% (minimum 75%, Baseline (adaptation disabled)); rectum: 67.0330% (minimum 70%, Baseline (adaptation disabled)); retina: 58.0952% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.6949% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 39.1026% (minimum 75%, Baseline (adaptation disabled)); skin: 54.9550% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.5472% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.5393% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.0093% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.4545% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.5472% (minimum 70%, Baseline (adaptation disabled)); thymus: 27.3543% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.5472% (minimum 65%, Baseline (adaptation disabled)); tongue: 62.2449% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 53.9823% (minimum 70%, Baseline (adaptation disabled))",-0.376457,-0.183051,-0.432292,0,4,partial,13.1,5.7,16.2,"thymus: 16.2 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); salivary gland: 5.7 nTPM (protected, limit 3); adipose tissue: 5.5 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 3); urinary bladder: 5.2 nTPM (protected, limit 3); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); spinal cord: 4.6 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147316,MCPH1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.0406183,0.0287102,0.00785223,0,2,partial,0.9,0.3,2.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147378,FATE1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340618,0.29871,0.247852,0,2,partial,0.9,0.3,2.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147378,FATE1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340618,0.29871,0.247852,0,2,partial,0.9,0.3,2.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147378,FATE1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340618,0.29871,0.247852,0,2,partial,0.9,0.3,2.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147378,FATE1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340618,0.29871,0.246141,0,2,partial,0.9,0.3,2.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147378,FATE1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0.1,0.6,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147381,MAGEA4,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.6,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147381,MAGEA4,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.6,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147381,MAGEA4,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.6,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147381,MAGEA4,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.34537,0.272851,0.24537,0,2,partial,0.1,0.6,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147381,MAGEA4,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Missing); adrenal gland: 80.0000% (minimum 99%, Missing); amygdala: 84.8485% (minimum 99%, Missing); basal ganglia: 84.8485% (minimum 99%, Missing); bone marrow: 32.9412% (minimum 99%, Missing); cerebellum: 90.3226% (minimum 99%, Missing); cerebral cortex: 75.6757% (minimum 99%, Missing); choroid plexus: 80.0000% (minimum 99%, Missing); colon: 58.3333% (minimum 97%, Missing); duodenum: 65.1163% (minimum 99%, Missing); esophagus: 63.6364% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 82.3529% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); kidney: 82.3529% (minimum 99%, Missing); liver: 68.2927% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 35.8974% (minimum 97%, Missing); midbrain: 82.3529% (minimum 99%, Missing); pancreas: 77.7778% (minimum 99%, Missing); parathyroid gland: 82.3529% (minimum 97%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); rectum: 49.1228% (minimum 97%, Missing); retina: 77.7778% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 84.8485% (minimum 99%, Missing); skin: 58.3333% (minimum 95%, Missing); small intestine: 63.6364% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 73.6842% (minimum 99%, Missing); spleen: 63.6364% (minimum 95%, Missing); stomach: 70.0000% (minimum 97%, Missing); thymus: 31.8182% (minimum 95%, Missing); thyroid gland: 70.0000% (minimum 95%, Missing); tongue: 96.5517% (minimum 97%, Missing); urinary bladder: 71.7949% (minimum 97%, Missing)",-0.631818,-0.611026,-0.660588,0,1,partial,5.7,5,6,"thymus: 6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147536,GINS4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 32.9412% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 65.1163% (minimum 75%, Missing); esophagus: 63.6364% (minimum 70%, Missing); liver: 68.2927% (minimum 75%, Missing); lymph node: 35.8974% (minimum 70%, Missing); rectum: 49.1228% (minimum 70%, Missing); skin: 58.3333% (minimum 65%, Missing); small intestine: 63.6364% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 73.6842% (minimum 75%, Missing); spleen: 63.6364% (minimum 65%, Missing); thymus: 31.8182% (minimum 65%, Missing)",-0.331818,-0.341026,-0.420588,0,1,partial,5.7,5,6,"thymus: 6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147536,GINS4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 32.9412% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 65.1163% (minimum 75%, Missing); esophagus: 63.6364% (minimum 70%, Missing); liver: 68.2927% (minimum 75%, Missing); lymph node: 35.8974% (minimum 70%, Missing); rectum: 49.1228% (minimum 70%, Missing); skin: 58.3333% (minimum 65%, Missing); small intestine: 63.6364% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 73.6842% (minimum 75%, Missing); spleen: 63.6364% (minimum 65%, Missing); thymus: 31.8182% (minimum 65%, Missing)",-0.331818,-0.341026,-0.420588,0,1,partial,5.7,5,6,"thymus: 6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147536,GINS4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 32.9412% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 65.1163% (minimum 75%, Missing); esophagus: 63.6364% (minimum 70%, Missing); liver: 68.2927% (minimum 75%, Missing); lymph node: 35.8974% (minimum 70%, Missing); rectum: 49.1228% (minimum 70%, Missing); skin: 58.3333% (minimum 65%, Missing); small intestine: 63.6364% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 73.6842% (minimum 75%, Missing); spleen: 63.6364% (minimum 65%, Missing); thymus: 31.8182% (minimum 65%, Missing)",-0.331818,-0.341026,-0.420588,0,1,partial,5.7,5,6,"thymus: 6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147536,GINS4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 32.9412% (minimum 75%, Baseline (adaptation disabled)); colon: 58.3333% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.1163% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.6364% (minimum 70%, Baseline (adaptation disabled)); liver: 68.2927% (minimum 75%, Baseline (adaptation disabled)); lymph node: 35.8974% (minimum 70%, Baseline (adaptation disabled)); rectum: 49.1228% (minimum 70%, Baseline (adaptation disabled)); skin: 58.3333% (minimum 65%, Baseline (adaptation disabled)); small intestine: 63.6364% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.6842% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.6364% (minimum 65%, Baseline (adaptation disabled)); thymus: 31.8182% (minimum 65%, Baseline (adaptation disabled))",-0.331818,-0.341026,-0.420588,0,1,partial,5.7,5,6,"thymus: 6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147536,GINS4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 98.2998% (minimum 99%, Missing); liver: 97.5460% (minimum 99%, Missing); lung: 91.5108% (minimum 99%, Missing); lymph node: 89.4515% (minimum 97%, Missing); skeletal muscle: 98.9114% (minimum 99%, Missing); small intestine: 97.8462% (minimum 99%, Missing); tongue: 95.3523% (minimum 97%, Missing)",0.0284615,-0.0754852,-0.0748921,0,80,unavailable,5.9,7.5,1.4,"lymph node: 7.5 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147570,DNAJC5B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328462,0.194515,0.165108,0,80,unavailable,5.9,7.5,1.4,"lymph node: 7.5 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147570,DNAJC5B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328462,0.194515,0.165108,0,80,unavailable,5.9,7.5,1.4,"lymph node: 7.5 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147570,DNAJC5B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328462,0.194515,0.165108,0,80,unavailable,5.9,7.5,1.4,"lymph node: 7.5 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147570,DNAJC5B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328462,0.194515,0.165108,0,80,unavailable,5.9,7.5,1.4,"lymph node: 7.5 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147570,DNAJC5B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Missing); adrenal gland: 96.9231% (minimum 99%, Missing); amygdala: 52.5000% (minimum 99%, Missing); basal ganglia: 64.9485% (minimum 99%, Missing); bone marrow: 98.4375% (minimum 99%, Missing); cerebral cortex: 35.3933% (minimum 99%, Missing); choroid plexus: 96.9231% (minimum 99%, Missing); hippocampal formation: 61.7647% (minimum 99%, Missing); hypothalamus: 12.0459% (minimum 99%, Missing); midbrain: 95.4545% (minimum 99%, Missing); pancreas: 80.7692% (minimum 99%, Missing); parathyroid gland: 91.3043% (minimum 97%, Missing); pituitary gland: 96.9231% (minimum 99%, Missing); retina: 92.6471% (minimum 99%, Missing); smooth muscle: 98.4375% (minimum 99%, Missing); spinal cord: 78.7500% (minimum 99%, Missing)",-0.142308,-0.0569565,-0.869541,0,80,unavailable,46,0.6,1.5,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147571,CRH,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 52.5000% (minimum 75%, Missing); basal ganglia: 64.9485% (minimum 75%, Missing); cerebral cortex: 35.3933% (minimum 75%, Missing); hippocampal formation: 61.7647% (minimum 75%, Missing); hypothalamus: 12.0459% (minimum 75%, Missing)",0.157692,0.213043,-0.629541,0,80,unavailable,46,0.6,1.5,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147571,CRH,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 52.5000% (minimum 75%, Missing); basal ganglia: 64.9485% (minimum 75%, Missing); cerebral cortex: 35.3933% (minimum 75%, Missing); hippocampal formation: 61.7647% (minimum 75%, Missing); hypothalamus: 12.0459% (minimum 75%, Missing)",0.157692,0.213043,-0.629541,0,80,unavailable,46,0.6,1.5,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147571,CRH,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 52.5000% (minimum 75%, Missing); basal ganglia: 64.9485% (minimum 75%, Missing); cerebral cortex: 35.3933% (minimum 75%, Missing); hippocampal formation: 61.7647% (minimum 75%, Missing); hypothalamus: 12.0459% (minimum 75%, Missing)",0.157692,0.213043,-0.629541,0,80,unavailable,46,0.6,1.5,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147571,CRH,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 52.5000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.9485% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 35.3933% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.7647% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 12.0459% (minimum 75%, Baseline (adaptation disabled))",0.157692,0.213043,-0.629541,0,80,unavailable,46,0.6,1.5,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147571,CRH,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 77.7778% (minimum 99%, Missing); choroid plexus: 77.7778% (minimum 99%, Missing); duodenum: 87.5000% (minimum 99%, Missing); heart muscle: 87.5000% (minimum 99%, Missing); kidney: 87.5000% (minimum 99%, Missing); lung: 87.5000% (minimum 99%, Missing); retina: 77.7778% (minimum 99%, Missing); skin: 87.5000% (minimum 95%, Missing); spleen: 87.5000% (minimum 95%, Missing)",-0.075,0.03,-0.212222,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147596,PRDM14,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.3,0.0277778,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147596,PRDM14,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.3,0.0277778,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147596,PRDM14,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.3,0.0277778,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147596,PRDM14,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.3,0.0277778,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147596,PRDM14,current_fixed,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 33.3333% (minimum 99%, Missing); retina: 4.0000% (minimum 99%, Missing)",0.05,0.03,-0.95,0,5,partial,2.4,0,0,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147613,PSKH2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 33.3333% (minimum 75%, Missing); retina: 4.0000% (minimum 75%, Missing)",0.35,0.3,-0.71,0,5,partial,2.4,0,0,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147613,PSKH2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 33.3333% (minimum 75%, Missing); retina: 4.0000% (minimum 75%, Missing)",0.35,0.3,-0.71,0,5,partial,2.4,0,0,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147613,PSKH2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 33.3333% (minimum 75%, Missing); retina: 4.0000% (minimum 75%, Missing)",0.35,0.3,-0.71,0,5,partial,2.4,0,0,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147613,PSKH2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 33.3333% (minimum 75%, Baseline (adaptation disabled)); retina: 4.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.71,0,5,partial,2.4,0,0,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147613,PSKH2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.0423% (minimum 95%, Missing); adrenal gland: 78.7162% (minimum 99%, Missing); amygdala: 83.2143% (minimum 99%, Missing); basal ganglia: 83.5125% (minimum 99%, Missing); bone marrow: 58.1047% (minimum 99%, Missing); cerebellum: 81.7544% (minimum 99%, Missing); cerebral cortex: 76.6447% (minimum 99%, Missing); choroid plexus: 89.2720% (minimum 99%, Missing); colon: 80.6228% (minimum 97%, Missing); duodenum: 85.6618% (minimum 99%, Missing); esophagus: 82.3322% (minimum 97%, Missing); heart muscle: 82.3322% (minimum 99%, Missing); hippocampal formation: 82.9181% (minimum 99%, Missing); hypothalamus: 85.3480% (minimum 99%, Missing); kidney: 85.6618% (minimum 99%, Missing); liver: 77.6667% (minimum 99%, Missing); lung: 83.5125% (minimum 99%, Missing); lymph node: 67.7326% (minimum 97%, Missing); midbrain: 80.3448% (minimum 99%, Missing); pancreas: 85.9779% (minimum 99%, Missing); parathyroid gland: 79.7945% (minimum 97%, Missing); pituitary gland: 88.9313% (minimum 99%, Missing); rectum: 79.5222% (minimum 97%, Missing); retina: 72.8125% (minimum 99%, Missing); salivary gland: 84.4203% (minimum 97%, Missing); skeletal muscle: 84.7273% (minimum 99%, Missing); skin: 74.6795% (minimum 95%, Missing); small intestine: 82.0423% (minimum 99%, Missing); smooth muscle: 77.1523% (minimum 99%, Missing); spinal cord: 75.4045% (minimum 99%, Missing); spleen: 77.6667% (minimum 95%, Missing); stomach: 84.7273% (minimum 97%, Missing); thymus: 61.3158% (minimum 95%, Missing); thyroid gland: 82.0423% (minimum 95%, Missing); tongue: 77.1523% (minimum 97%, Missing); urinary bladder: 79.7945% (minimum 97%, Missing)",-0.336842,-0.292674,-0.408953,0,4,partial,16.8,11.1,14.7,"bone marrow: 16.8 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 2); retina: 8.7 nTPM (vital, limit 1); skin: 7.9 nTPM (manageable, limit 5); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 2); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); urinary bladder: 5.9 nTPM (protected, limit 2); parathyroid gland: 5.9 nTPM (protected, limit 2); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); cerebellum: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 5.1 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); hypothalamus: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147874,HAUS6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 58.1047% (minimum 75%, Missing); lymph node: 67.7326% (minimum 70%, Missing); retina: 72.8125% (minimum 75%, Missing); thymus: 61.3158% (minimum 65%, Missing)",-0.0368421,-0.0226744,-0.168953,0,4,partial,16.8,11.1,14.7,"bone marrow: 16.8 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 2); retina: 8.7 nTPM (vital, limit 1); skin: 7.9 nTPM (manageable, limit 5); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 2); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); urinary bladder: 5.9 nTPM (protected, limit 2); parathyroid gland: 5.9 nTPM (protected, limit 2); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); cerebellum: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 5.1 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); hypothalamus: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147874,HAUS6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 58.1047% (minimum 75%, Missing); lymph node: 67.7326% (minimum 70%, Missing); retina: 72.8125% (minimum 75%, Missing); thymus: 61.3158% (minimum 65%, Missing)",-0.0368421,-0.0226744,-0.168953,0,4,partial,16.8,11.1,14.7,"bone marrow: 16.8 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 3); retina: 8.7 nTPM (vital, limit 1); skin: 7.9 nTPM (manageable, limit 5); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 3); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); urinary bladder: 5.9 nTPM (protected, limit 3); parathyroid gland: 5.9 nTPM (protected, limit 3); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); cerebellum: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 5.1 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 3); skeletal muscle: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); hypothalamus: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147874,HAUS6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 58.1047% (minimum 75%, Missing); lymph node: 67.7326% (minimum 70%, Missing); retina: 72.8125% (minimum 75%, Missing); thymus: 61.3158% (minimum 65%, Missing)",-0.0368421,-0.0226744,-0.168953,0,4,partial,16.8,11.1,14.7,"bone marrow: 16.8 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 3); retina: 8.7 nTPM (vital, limit 1); skin: 7.9 nTPM (manageable, limit 5); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 3); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); urinary bladder: 5.9 nTPM (protected, limit 3); parathyroid gland: 5.9 nTPM (protected, limit 3); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); cerebellum: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 5.1 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 3); skeletal muscle: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); hypothalamus: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147874,HAUS6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 58.1047% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.7326% (minimum 70%, Baseline (adaptation disabled)); retina: 72.8125% (minimum 75%, Baseline (adaptation disabled)); thymus: 61.3158% (minimum 65%, Baseline (adaptation disabled))",-0.0368421,-0.0226744,-0.168953,0,4,partial,16.8,11.1,14.7,"bone marrow: 16.8 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 3); retina: 8.7 nTPM (vital, limit 1); skin: 7.9 nTPM (manageable, limit 5); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 3); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); urinary bladder: 5.9 nTPM (protected, limit 3); parathyroid gland: 5.9 nTPM (protected, limit 3); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); cerebellum: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 5.1 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 3); skeletal muscle: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); hypothalamus: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147874,HAUS6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.9474% (minimum 95%, Uncertain); adrenal gland: 57.6923% (minimum 99%, Uncertain); amygdala: 72.4138% (minimum 99%, Missing); basal ganglia: 64.4172% (minimum 99%, Missing); bone marrow: 92.9204% (minimum 99%, Uncertain); cerebellum: 73.4266% (minimum 99%, Uncertain); cerebral cortex: 57.6923% (minimum 99%, Uncertain); choroid plexus: 82.6772% (minimum 99%, Missing); colon: 59.3220% (minimum 97%, Missing); duodenum: 86.0656% (minimum 99%, Missing); esophagus: 77.2059% (minimum 97%, Uncertain); heart muscle: 73.4266% (minimum 99%, Uncertain); hippocampal formation: 66.0377% (minimum 99%, Missing); hypothalamus: 68.1818% (minimum 99%, Missing); kidney: 73.9437% (minimum 99%, Uncertain); liver: 75.0000% (minimum 99%, Uncertain); lung: 82.6772% (minimum 99%, Missing); lymph node: 66.0377% (minimum 97%, Uncertain); midbrain: 76.6423% (minimum 99%, Missing); pancreas: 62.1302% (minimum 99%, Uncertain); parathyroid gland: 73.9437% (minimum 97%, Uncertain); pituitary gland: 39.6226% (minimum 99%, Missing); rectum: 86.0656% (minimum 97%, Missing); retina: 86.7769% (minimum 99%, Missing); salivary gland: 55.8511% (minimum 97%, Uncertain); skeletal muscle: 26.7857% (minimum 99%, Uncertain); skin: 85.3659% (minimum 95%, Uncertain); small intestine: 69.5364% (minimum 99%, Missing); smooth muscle: 77.2059% (minimum 99%, Uncertain); spinal cord: 80.7692% (minimum 99%, Missing); spleen: 51.7241% (minimum 95%, Uncertain); stomach: 77.2059% (minimum 97%, Uncertain); thymus: 84.0000% (minimum 95%, Missing); thyroid gland: 58.6592% (minimum 95%, Uncertain); tongue: 43.9331% (minimum 97%, Missing); urinary bladder: 78.3582% (minimum 97%, Uncertain)",-0.432759,-0.530669,-0.722143,0,3,partial,28.7,13.4,9.8,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 2); spleen: 9.8 nTPM (manageable, limit 5); salivary gland: 8.3 nTPM (protected, limit 2); adrenal gland: 7.7 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (manageable, limit 5); colon: 7.2 nTPM (protected, limit 2); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); hippocampal formation: 5.4 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147912,FBXO10,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 57.6923% (minimum 75%, Uncertain); amygdala: 72.4138% (minimum 75%, Missing); basal ganglia: 64.4172% (minimum 75%, Missing); cerebellum: 73.4266% (minimum 75%, Uncertain); cerebral cortex: 57.6923% (minimum 75%, Uncertain); colon: 59.3220% (minimum 70%, Missing); heart muscle: 73.4266% (minimum 75%, Uncertain); hippocampal formation: 66.0377% (minimum 75%, Missing); hypothalamus: 68.1818% (minimum 75%, Missing); kidney: 73.9437% (minimum 75%, Uncertain); lymph node: 66.0377% (minimum 70%, Uncertain); pancreas: 62.1302% (minimum 75%, Uncertain); pituitary gland: 39.6226% (minimum 75%, Missing); salivary gland: 55.8511% (minimum 70%, Uncertain); skeletal muscle: 26.7857% (minimum 75%, Uncertain); small intestine: 69.5364% (minimum 75%, Missing); spleen: 51.7241% (minimum 65%, Uncertain); thyroid gland: 58.6592% (minimum 65%, Uncertain); tongue: 43.9331% (minimum 70%, Missing)",-0.132759,-0.260669,-0.482143,0,3,partial,28.7,13.4,9.8,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 2); spleen: 9.8 nTPM (manageable, limit 5); salivary gland: 8.3 nTPM (protected, limit 2); adrenal gland: 7.7 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (manageable, limit 5); colon: 7.2 nTPM (protected, limit 2); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); hippocampal formation: 5.4 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147912,FBXO10,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 57.6923% (minimum 75%, Uncertain); amygdala: 72.4138% (minimum 75%, Missing); basal ganglia: 64.4172% (minimum 75%, Missing); cerebellum: 73.4266% (minimum 75%, Uncertain); cerebral cortex: 57.6923% (minimum 75%, Uncertain); colon: 59.3220% (minimum 70%, Missing); heart muscle: 73.4266% (minimum 75%, Uncertain); hippocampal formation: 66.0377% (minimum 75%, Missing); hypothalamus: 68.1818% (minimum 75%, Missing); kidney: 73.9437% (minimum 75%, Uncertain); lymph node: 66.0377% (minimum 70%, Uncertain); pancreas: 62.1302% (minimum 75%, Uncertain); pituitary gland: 39.6226% (minimum 75%, Missing); salivary gland: 55.8511% (minimum 70%, Uncertain); skeletal muscle: 26.7857% (minimum 75%, Uncertain); small intestine: 69.5364% (minimum 75%, Missing); spleen: 51.7241% (minimum 65%, Uncertain); thyroid gland: 58.6592% (minimum 65%, Uncertain); tongue: 43.9331% (minimum 70%, Missing)",-0.132759,-0.260669,-0.482143,0,3,partial,28.7,13.4,9.8,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 3); spleen: 9.8 nTPM (manageable, limit 5); salivary gland: 8.3 nTPM (protected, limit 3); adrenal gland: 7.7 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (manageable, limit 5); colon: 7.2 nTPM (protected, limit 3); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); hippocampal formation: 5.4 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147912,FBXO10,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 57.6923% (minimum 75%, Uncertain); amygdala: 72.4138% (minimum 75%, Missing); basal ganglia: 64.4172% (minimum 75%, Missing); cerebellum: 73.4266% (minimum 75%, Uncertain); cerebral cortex: 57.6923% (minimum 75%, Uncertain); colon: 59.3220% (minimum 70%, Missing); heart muscle: 73.4266% (minimum 75%, Uncertain); hippocampal formation: 66.0377% (minimum 75%, Missing); hypothalamus: 68.1818% (minimum 75%, Missing); kidney: 73.9437% (minimum 75%, Uncertain); lymph node: 66.0377% (minimum 70%, Uncertain); pancreas: 62.1302% (minimum 75%, Uncertain); pituitary gland: 39.6226% (minimum 75%, Missing); salivary gland: 55.8511% (minimum 70%, Uncertain); skeletal muscle: 26.7857% (minimum 75%, Uncertain); small intestine: 69.5364% (minimum 75%, Missing); spleen: 51.7241% (minimum 65%, Uncertain); thyroid gland: 58.6592% (minimum 65%, Uncertain); tongue: 43.9331% (minimum 70%, Missing)",-0.132759,-0.260669,-0.482143,0,3,partial,28.7,13.4,9.8,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 3); spleen: 9.8 nTPM (manageable, limit 5); salivary gland: 8.3 nTPM (protected, limit 3); adrenal gland: 7.7 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (manageable, limit 5); colon: 7.2 nTPM (protected, limit 3); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); hippocampal formation: 5.4 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147912,FBXO10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 57.6923% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.4138% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.4172% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.4266% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.6923% (minimum 75%, Baseline (adaptation disabled)); colon: 59.3220% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 73.4266% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 66.0377% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.1818% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.9437% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.0377% (minimum 70%, Baseline (adaptation disabled)); pancreas: 62.1302% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 39.6226% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.8511% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 26.7857% (minimum 75%, Baseline (adaptation disabled)); small intestine: 69.5364% (minimum 75%, Baseline (adaptation disabled)); spleen: 51.7241% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.6592% (minimum 65%, Baseline (adaptation disabled)); tongue: 43.9331% (minimum 70%, Baseline (adaptation disabled))",-0.132759,-0.260669,-0.482143,0,3,partial,28.7,13.4,9.8,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 3); spleen: 9.8 nTPM (manageable, limit 5); salivary gland: 8.3 nTPM (protected, limit 3); adrenal gland: 7.7 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (manageable, limit 5); colon: 7.2 nTPM (protected, limit 3); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); hippocampal formation: 5.4 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000147912,FBXO10,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5000% (minimum 90%, Approved); adrenal gland: 84.0000% (minimum 99%, Missing); amygdala: 78.6096% (minimum 99%, Missing); basal ganglia: 79.4595% (minimum 99%, Missing); bone marrow: 54.6468% (minimum 99%, Missing); cerebellum: 71.3592% (minimum 99%, Missing); cerebral cortex: 76.5625% (minimum 99%, Missing); choroid plexus: 86.9822% (minimum 99%, Missing); colon: 81.2155% (minimum 97%, Missing); duodenum: 84.0000% (minimum 98%, Approved); esophagus: 81.2155% (minimum 97%, Missing); heart muscle: 90.7407% (minimum 99%, Missing); hippocampal formation: 78.1915% (minimum 99%, Missing); hypothalamus: 80.7692% (minimum 99%, Missing); kidney: 80.7692% (minimum 99%, Missing); liver: 81.2155% (minimum 99%, Missing); lung: 82.1229% (minimum 99%, Missing); lymph node: 71.0145% (minimum 97%, Missing); midbrain: 78.1915% (minimum 99%, Missing); pancreas: 85.4651% (minimum 99%, Missing); parathyroid gland: 77.7778% (minimum 95%, Approved); pituitary gland: 84.9711% (minimum 99%, Missing); rectum: 79.4595% (minimum 97%, Missing); retina: 62.0253% (minimum 99%, Missing); salivary gland: 82.1229% (minimum 97%, Missing); skeletal muscle: 90.1840% (minimum 99%, Missing); skin: 80.7692% (minimum 95%, Missing); small intestine: 84.0000% (minimum 99%, Missing); smooth muscle: 76.1658% (minimum 98%, Approved); spinal cord: 76.5625% (minimum 99%, Missing); spleen: 75.0000% (minimum 90%, Approved); stomach: 83.5227% (minimum 97%, Missing); thymus: 56.7568% (minimum 95%, Missing); thyroid gland: 80.3279% (minimum 95%, Missing); tongue: 90.1840% (minimum 97%, Missing); urinary bladder: 82.5843% (minimum 97%, Missing)",-0.382432,-0.259855,-0.443532,0,2,partial,12.2,6,11.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 11.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 2); cerebral cortex: 4.5 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 4); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); liver: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 2); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148019,CEP78,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.6468% (minimum 75%, Missing); cerebellum: 71.3592% (minimum 75%, Missing); retina: 62.0253% (minimum 75%, Missing); thymus: 56.7568% (minimum 65%, Missing)",-0.0824324,0.0101449,-0.203532,0,2,partial,12.2,6,11.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 11.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 2); cerebral cortex: 4.5 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 4); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); liver: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 2); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148019,CEP78,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.6468% (minimum 75%, Missing); cerebellum: 71.3592% (minimum 75%, Missing); retina: 62.0253% (minimum 75%, Missing); thymus: 56.7568% (minimum 65%, Missing)",-0.0824324,0.0101449,-0.203532,0,2,partial,12.2,6,11.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 11.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 2); cerebral cortex: 4.5 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 4); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); esophagus: 3.4 nTPM (protected, limit 3); liver: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); lung: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 2); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148019,CEP78,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.6468% (minimum 75%, Missing); cerebellum: 71.3592% (minimum 75%, Missing); retina: 62.0253% (minimum 75%, Missing); thymus: 56.7568% (minimum 65%, Missing)",-0.0824324,0.0101449,-0.203532,0,2,partial,12.2,6,11.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 11.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 2); cerebral cortex: 4.5 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 4); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); esophagus: 3.4 nTPM (protected, limit 3); liver: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); lung: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 2); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148019,CEP78,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.6468% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 71.3592% (minimum 75%, Baseline (adaptation disabled)); retina: 62.0253% (minimum 75%, Baseline (adaptation disabled)); thymus: 56.7568% (minimum 65%, Baseline (adaptation disabled))",-0.0824324,0.0101449,-0.203532,0,2,partial,12.2,6,11.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 11.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); esophagus: 3.4 nTPM (protected, limit 3); liver: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); lung: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148019,CEP78,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148156,ACTL7B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148156,ACTL7B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148156,ACTL7B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148156,ACTL7B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148156,ACTL7B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.5217% (minimum 99%, Missing); amygdala: 96.1039% (minimum 99%, Missing); basal ganglia: 95.6897% (minimum 99%, Missing); bone marrow: 83.7736% (minimum 99%, Missing); cerebellum: 91.7355% (minimum 99%, Missing); cerebral cortex: 94.8718% (minimum 99%, Missing); choroid plexus: 94.4681% (minimum 99%, Missing); colon: 90.9836% (minimum 97%, Missing); duodenum: 92.8870% (minimum 99%, Missing); esophagus: 92.5000% (minimum 97%, Missing); heart muscle: 95.6897% (minimum 99%, Missing); hippocampal formation: 95.6897% (minimum 99%, Missing); hypothalamus: 95.6897% (minimum 99%, Missing); kidney: 93.2773% (minimum 99%, Missing); liver: 89.5161% (minimum 99%, Missing); lung: 93.6709% (minimum 99%, Missing); midbrain: 96.5217% (minimum 99%, Missing); pancreas: 88.8000% (minimum 99%, Missing); parathyroid gland: 96.5217% (minimum 97%, Missing); pituitary gland: 94.0678% (minimum 99%, Missing); rectum: 93.6709% (minimum 97%, Missing); retina: 88.0952% (minimum 99%, Missing); salivary gland: 94.8718% (minimum 97%, Missing); skeletal muscle: 94.4681% (minimum 99%, Missing); skin: 91.3580% (minimum 95%, Missing); small intestine: 89.8785% (minimum 99%, Missing); smooth muscle: 98.2301% (minimum 99%, Missing); spinal cord: 96.9432% (minimum 99%, Missing); thyroid gland: 81.0219% (minimum 95%, Missing); tongue: 96.5217% (minimum 97%, Missing); urinary bladder: 96.9432% (minimum 97%, Missing)",-0.139781,-0.0601639,-0.152264,0,80,unavailable,4.3,2.2,5.2,"thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148200,NR6A1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.160219,0.209836,0.0877358,0,80,unavailable,4.3,2.2,5.2,"thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148200,NR6A1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.160219,0.209836,0.0877358,0,80,unavailable,4.3,2.2,5.2,"thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148200,NR6A1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.160219,0.209836,0.0877358,0,80,unavailable,4.3,2.2,5.2,"thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148200,NR6A1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.160219,0.209836,0.0877358,0,80,unavailable,4.3,2.2,5.2,"thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148200,NR6A1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148215,OR5C1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148215,OR5C1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148215,OR5C1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148215,OR5C1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148215,OR5C1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.3607% (minimum 99%, Missing); retina: 19.4175% (minimum 99%, Missing)",0.05,0.03,-0.795825,0,80,unavailable,24.9,0,0,"retina: 24.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148602,LRIT1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 19.4175% (minimum 75%, Missing)",0.35,0.3,-0.555825,0,80,unavailable,24.9,0,0,"retina: 24.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148602,LRIT1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 19.4175% (minimum 75%, Missing)",0.35,0.3,-0.555825,0,80,unavailable,24.9,0,0,"retina: 24.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148602,LRIT1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 19.4175% (minimum 75%, Missing)",0.35,0.3,-0.555825,0,80,unavailable,24.9,0,0,"retina: 24.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148602,LRIT1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 19.4175% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.555825,0,80,unavailable,24.9,0,0,"retina: 24.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148602,LRIT1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); amygdala: 12.9032% (minimum 99%, Missing); basal ganglia: 10.8108% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 7.1429% (minimum 99%, Missing); choroid plexus: 2.3392% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); esophagus: 88.8889% (minimum 97%, Missing); heart muscle: 61.5385% (minimum 99%, Missing); hippocampal formation: 30.7692% (minimum 99%, Missing); hypothalamus: 27.5862% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); midbrain: 20.0000% (minimum 99%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); retina: 0.5900% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); small intestine: 88.8889% (minimum 99%, Missing); spinal cord: 88.8889% (minimum 99%, Missing); stomach: 80.0000% (minimum 97%, Missing)",-0.15,-0.17,-0.9841,0,80,unavailable,134.8,0.2,0.2,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148604,RGR,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 12.9032% (minimum 75%, Missing); basal ganglia: 10.8108% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 7.1429% (minimum 75%, Missing); choroid plexus: 2.3392% (minimum 75%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 30.7692% (minimum 75%, Missing); hypothalamus: 27.5862% (minimum 75%, Missing); midbrain: 20.0000% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 0.5900% (minimum 75%, Missing)",0.15,0.1,-0.7441,0,80,unavailable,134.8,0.2,0.2,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148604,RGR,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 12.9032% (minimum 75%, Missing); basal ganglia: 10.8108% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 7.1429% (minimum 75%, Missing); choroid plexus: 2.3392% (minimum 75%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 30.7692% (minimum 75%, Missing); hypothalamus: 27.5862% (minimum 75%, Missing); midbrain: 20.0000% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 0.5900% (minimum 75%, Missing)",0.15,0.1,-0.7441,0,80,unavailable,134.8,0.2,0.2,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148604,RGR,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 12.9032% (minimum 75%, Missing); basal ganglia: 10.8108% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 7.1429% (minimum 75%, Missing); choroid plexus: 2.3392% (minimum 75%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 30.7692% (minimum 75%, Missing); hypothalamus: 27.5862% (minimum 75%, Missing); midbrain: 20.0000% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 0.5900% (minimum 75%, Missing)",0.15,0.1,-0.7441,0,80,unavailable,134.8,0.2,0.2,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148604,RGR,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 12.9032% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 10.8108% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 7.1429% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 2.3392% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 61.5385% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 30.7692% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 27.5862% (minimum 75%, Baseline (adaptation disabled)); midbrain: 20.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 0.5900% (minimum 75%, Baseline (adaptation disabled))",0.15,0.1,-0.7441,0,80,unavailable,134.8,0.2,0.2,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148604,RGR,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.7011% (minimum 99%, Missing); amygdala: 95.5056% (minimum 99%, Missing); basal ganglia: 96.5909% (minimum 99%, Missing); bone marrow: 96.5909% (minimum 98%, Approved); cerebral cortex: 85.8586% (minimum 99%, Missing); choroid plexus: 98.8372% (minimum 99%, Missing); colon: 93.4066% (minimum 97%, Missing); duodenum: 94.4444% (minimum 98%, Approved); esophagus: 92.3913% (minimum 95%, Approved); hippocampal formation: 89.4737% (minimum 99%, Missing); hypothalamus: 80.9524% (minimum 99%, Missing); liver: 95.5056% (minimum 98%, Approved); lung: 97.7011% (minimum 99%, Missing); lymph node: 93.4066% (minimum 97%, Missing); midbrain: 94.4444% (minimum 99%, Missing); pancreas: 98.8372% (minimum 99%, Missing); parathyroid gland: 40.0943% (minimum 97%, Missing); pituitary gland: 98.8372% (minimum 99%, Missing); rectum: 90.4255% (minimum 95%, Approved); retina: 98.8372% (minimum 99%, Missing); skeletal muscle: 90.4255% (minimum 98%, Approved); small intestine: 86.7347% (minimum 98%, Approved); smooth muscle: 96.5909% (minimum 98%, Approved); spinal cord: 96.5909% (minimum 99%, Missing); spleen: 88.5417% (minimum 95%, Missing); stomach: 92.3913% (minimum 97%, Missing); tongue: 94.4444% (minimum 97%, Missing); urinary bladder: 79.4393% (minimum 97%, Missing)",-0.0645833,-0.569057,-0.180476,0,3,partial,2,12.7,1.1,"parathyroid gland: 12.7 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148680,HTR7,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"parathyroid gland: 40.0943% (minimum 70%, Missing)",0.235417,-0.299057,0.0595238,0,3,partial,2,12.7,1.1,"parathyroid gland: 12.7 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148680,HTR7,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"parathyroid gland: 40.0943% (minimum 70%, Missing)",0.235417,-0.299057,0.0595238,0,3,partial,2,12.7,1.1,"parathyroid gland: 12.7 nTPM (protected, limit 3); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148680,HTR7,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"parathyroid gland: 40.0943% (minimum 70%, Missing)",0.235417,-0.299057,0.0595238,0,3,partial,2,12.7,1.1,"parathyroid gland: 12.7 nTPM (protected, limit 3); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148680,HTR7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"parathyroid gland: 40.0943% (minimum 70%, Baseline (adaptation disabled))",0.235417,-0.299057,0.0595238,0,3,partial,2,12.7,1.1,"parathyroid gland: 12.7 nTPM (protected, limit 3); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148680,HTR7,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.9612% (minimum 95%, Enhanced); amygdala: 84.6774% (minimum 99%, Missing); basal ganglia: 83.8084% (minimum 99%, Missing); cerebellum: 94.2308% (minimum 99%, Missing); cerebral cortex: 84.3858% (minimum 99%, Missing); choroid plexus: 82.7703% (minimum 99%, Missing); colon: 94.2308% (minimum 97%, Missing); duodenum: 96.7105% (minimum 99%, Missing); hippocampal formation: 83.9041% (minimum 99%, Missing); hypothalamus: 85.8645% (minimum 99%, Missing); kidney: 91.4179% (minimum 99%, Missing); midbrain: 87.9187% (minimum 99%, Missing); parathyroid gland: 90.5172% (minimum 97%, Missing); pituitary gland: 90.4059% (minimum 99%, Missing); rectum: 96.7105% (minimum 97%, Missing); retina: 87.3960% (minimum 99%, Missing); small intestine: 95.8279% (minimum 99%, Missing); smooth muscle: 94.7165% (minimum 99%, Missing); spinal cord: 89.9633% (minimum 99%, Missing); stomach: 95.0841% (minimum 97%, Missing)",0.0145669,-0.0648276,-0.162297,0,10,partial,15.3,7.7,6.2,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); kidney: 6.9 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148814,LRRC27,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.314567,0.205172,0.0777027,0,10,partial,15.3,7.7,6.2,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); kidney: 6.9 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148814,LRRC27,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.314567,0.205172,0.0777027,0,10,partial,15.3,7.7,6.2,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 3); kidney: 6.9 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148814,LRRC27,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.314567,0.205172,0.0777027,0,10,partial,15.3,7.7,6.2,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 3); kidney: 6.9 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148814,LRRC27,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.272208,0.205172,0.0777027,0,10,partial,15.3,7.7,6.2,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 3); kidney: 6.9 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); spleen: 5.4 nTPM (manageable, limit 5); colon: 4.5 nTPM (protected, limit 3); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); pancreas: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148814,LRRC27,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.6620% (minimum 95%, Missing); adrenal gland: 92.3611% (minimum 99%, Missing); amygdala: 91.7241% (minimum 99%, Missing); basal ganglia: 91.7241% (minimum 99%, Missing); cerebellum: 90.1695% (minimum 99%, Missing); cerebral cortex: 91.0959% (minimum 99%, Missing); colon: 91.4089% (minimum 97%, Missing); duodenum: 93.6620% (minimum 99%, Missing); esophagus: 81.3456% (minimum 97%, Missing); heart muscle: 94.6619% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 93.0070% (minimum 99%, Missing); kidney: 88.9632% (minimum 99%, Missing); liver: 78.0059% (minimum 99%, Missing); lung: 95.0000% (minimum 99%, Missing); midbrain: 91.7241% (minimum 99%, Missing); pancreas: 91.7241% (minimum 99%, Missing); pituitary gland: 94.6619% (minimum 99%, Missing); salivary gland: 89.8649% (minimum 97%, Missing); skeletal muscle: 90.1695% (minimum 99%, Missing); skin: 90.7850% (minimum 95%, Missing); small intestine: 86.0841% (minimum 99%, Missing); smooth muscle: 98.8848% (minimum 99%, Missing); spinal cord: 86.9281% (minimum 99%, Missing); spleen: 84.9840% (minimum 95%, Missing); stomach: 91.7241% (minimum 97%, Missing); thyroid gland: 94.3262% (minimum 95%, Missing); urinary bladder: 90.4762% (minimum 97%, Missing)",-0.10016,-0.156544,-0.209941,0,80,unavailable,7.5,6.1,4.7,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148832,PAOX,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19984,0.113456,0.0300587,0,80,unavailable,7.5,6.1,4.7,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148832,PAOX,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19984,0.113456,0.0300587,0,80,unavailable,7.5,6.1,4.7,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148832,PAOX,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19984,0.113456,0.0300587,0,80,unavailable,7.5,6.1,4.7,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148832,PAOX,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19984,0.113456,0.0300587,0,80,unavailable,7.5,6.1,4.7,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148832,PAOX,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.4894% (minimum 99%, Missing)",0.0393778,0.03,-0.00510574,0,3,partial,3.1,8.6,7.8,"basal ganglia: 2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148848,ADAM12,admission_only,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339378,0.3,0.234894,0,3,partial,3.1,8.6,7.8,"basal ganglia: 2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148848,ADAM12,selectivity_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339378,0.3,0.234894,0,3,partial,3.1,8.6,7.8,"basal ganglia: 2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148848,ADAM12,grid_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339378,0.3,0.234894,0,3,partial,3.1,8.6,7.8,"basal ganglia: 2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148848,ADAM12,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.29356,0.238129,0.226779,0,3,partial,3.1,8.6,7.8,"urinary bladder: 8.6 nTPM (protected, limit 3); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 3.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148848,ADAM12,current_fixed,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.9603% (minimum 90%, Approved); adrenal gland: 65.7596% (minimum 99%, Missing); amygdala: 42.2125% (minimum 99%, Missing); basal ganglia: 39.3487% (minimum 99%, Missing); bone marrow: 72.5000% (minimum 99%, Missing); cerebellum: 39.4022% (minimum 99%, Missing); cerebral cortex: 44.8916% (minimum 99%, Missing); choroid plexus: 44.8223% (minimum 99%, Missing); colon: 70.2179% (minimum 97%, Missing); duodenum: 77.5401% (minimum 99%, Missing); esophagus: 71.7822% (minimum 97%, Missing); heart muscle: 53.3088% (minimum 99%, Missing); hippocampal formation: 46.2520% (minimum 99%, Missing); hypothalamus: 49.4881% (minimum 99%, Missing); kidney: 52.3466% (minimum 99%, Missing); liver: 61.5711% (minimum 99%, Missing); lung: 76.9231% (minimum 99%, Missing); lymph node: 75.7180% (minimum 97%, Missing); midbrain: 52.5362% (minimum 99%, Missing); pancreas: 64.4444% (minimum 99%, Missing); parathyroid gland: 62.7706% (minimum 97%, Missing); pituitary gland: 56.0928% (minimum 99%, Missing); rectum: 74.9354% (minimum 97%, Missing); retina: 44.2748% (minimum 99%, Missing); salivary gland: 71.7822% (minimum 97%, Missing); skeletal muscle: 37.5162% (minimum 99%, Missing); skin: 70.5596% (minimum 95%, Missing); small intestine: 75.9162% (minimum 99%, Missing); smooth muscle: 73.7913% (minimum 99%, Missing); spinal cord: 56.2016% (minimum 99%, Missing); spleen: 73.2323% (minimum 95%, Missing); stomach: 66.3616% (minimum 97%, Missing); thymus: 54.6139% (minimum 95%, Missing); thyroid gland: 69.3780% (minimum 95%, Missing); tongue: 41.4286% (minimum 97%, Missing); urinary bladder: 73.4177% (minimum 97%, Missing)",-0.403861,-0.555714,-0.614838,0,5,partial,48.3,41,24.1,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 2); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 2); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 2); thyroid gland: 12.8 nTPM (manageable, limit 5); colon: 12.3 nTPM (protected, limit 2); skin: 12.1 nTPM (manageable, limit 5); esophagus: 11.4 nTPM (protected, limit 2); salivary gland: 11.4 nTPM (protected, limit 2); adipose tissue: 11.3 nTPM (manageable, limit 10); bone marrow: 11 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); urinary bladder: 10.5 nTPM (protected, limit 2); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); lymph node: 9.3 nTPM (protected, limit 2); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148950,IMMP1L,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.7596% (minimum 75%, Missing); amygdala: 42.2125% (minimum 75%, Missing); basal ganglia: 39.3487% (minimum 75%, Missing); bone marrow: 72.5000% (minimum 75%, Missing); cerebellum: 39.4022% (minimum 75%, Missing); cerebral cortex: 44.8916% (minimum 75%, Missing); choroid plexus: 44.8223% (minimum 75%, Missing); heart muscle: 53.3088% (minimum 75%, Missing); hippocampal formation: 46.2520% (minimum 75%, Missing); hypothalamus: 49.4881% (minimum 75%, Missing); kidney: 52.3466% (minimum 75%, Missing); liver: 61.5711% (minimum 75%, Missing); midbrain: 52.5362% (minimum 75%, Missing); pancreas: 64.4444% (minimum 75%, Missing); parathyroid gland: 62.7706% (minimum 70%, Missing); pituitary gland: 56.0928% (minimum 75%, Missing); retina: 44.2748% (minimum 75%, Missing); skeletal muscle: 37.5162% (minimum 75%, Missing); smooth muscle: 73.7913% (minimum 75%, Missing); spinal cord: 56.2016% (minimum 75%, Missing); stomach: 66.3616% (minimum 70%, Missing); thymus: 54.6139% (minimum 65%, Missing); tongue: 41.4286% (minimum 70%, Missing)",-0.103861,-0.285714,-0.374838,0,5,partial,48.3,41,24.1,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 2); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 2); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 2); thyroid gland: 12.8 nTPM (manageable, limit 5); colon: 12.3 nTPM (protected, limit 2); skin: 12.1 nTPM (manageable, limit 5); esophagus: 11.4 nTPM (protected, limit 2); salivary gland: 11.4 nTPM (protected, limit 2); adipose tissue: 11.3 nTPM (manageable, limit 10); bone marrow: 11 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); urinary bladder: 10.5 nTPM (protected, limit 2); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); lymph node: 9.3 nTPM (protected, limit 2); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148950,IMMP1L,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.7596% (minimum 75%, Missing); amygdala: 42.2125% (minimum 75%, Missing); basal ganglia: 39.3487% (minimum 75%, Missing); bone marrow: 72.5000% (minimum 75%, Missing); cerebellum: 39.4022% (minimum 75%, Missing); cerebral cortex: 44.8916% (minimum 75%, Missing); choroid plexus: 44.8223% (minimum 75%, Missing); heart muscle: 53.3088% (minimum 75%, Missing); hippocampal formation: 46.2520% (minimum 75%, Missing); hypothalamus: 49.4881% (minimum 75%, Missing); kidney: 52.3466% (minimum 75%, Missing); liver: 61.5711% (minimum 75%, Missing); midbrain: 52.5362% (minimum 75%, Missing); pancreas: 64.4444% (minimum 75%, Missing); parathyroid gland: 62.7706% (minimum 70%, Missing); pituitary gland: 56.0928% (minimum 75%, Missing); retina: 44.2748% (minimum 75%, Missing); skeletal muscle: 37.5162% (minimum 75%, Missing); smooth muscle: 73.7913% (minimum 75%, Missing); spinal cord: 56.2016% (minimum 75%, Missing); stomach: 66.3616% (minimum 70%, Missing); thymus: 54.6139% (minimum 65%, Missing); tongue: 41.4286% (minimum 70%, Missing)",-0.103861,-0.285714,-0.374838,0,5,partial,48.3,41,24.1,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 3); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 3); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 3); thyroid gland: 12.8 nTPM (manageable, limit 5); colon: 12.3 nTPM (protected, limit 3); skin: 12.1 nTPM (manageable, limit 5); esophagus: 11.4 nTPM (protected, limit 3); salivary gland: 11.4 nTPM (protected, limit 3); adipose tissue: 11.3 nTPM (manageable, limit 10); bone marrow: 11 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); urinary bladder: 10.5 nTPM (protected, limit 3); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); lymph node: 9.3 nTPM (protected, limit 3); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148950,IMMP1L,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.7596% (minimum 75%, Missing); amygdala: 42.2125% (minimum 75%, Missing); basal ganglia: 39.3487% (minimum 75%, Missing); bone marrow: 72.5000% (minimum 75%, Missing); cerebellum: 39.4022% (minimum 75%, Missing); cerebral cortex: 44.8916% (minimum 75%, Missing); choroid plexus: 44.8223% (minimum 75%, Missing); heart muscle: 53.3088% (minimum 75%, Missing); hippocampal formation: 46.2520% (minimum 75%, Missing); hypothalamus: 49.4881% (minimum 75%, Missing); kidney: 52.3466% (minimum 75%, Missing); liver: 61.5711% (minimum 75%, Missing); midbrain: 52.5362% (minimum 75%, Missing); pancreas: 64.4444% (minimum 75%, Missing); parathyroid gland: 62.7706% (minimum 70%, Missing); pituitary gland: 56.0928% (minimum 75%, Missing); retina: 44.2748% (minimum 75%, Missing); skeletal muscle: 37.5162% (minimum 75%, Missing); smooth muscle: 73.7913% (minimum 75%, Missing); spinal cord: 56.2016% (minimum 75%, Missing); stomach: 66.3616% (minimum 70%, Missing); thymus: 54.6139% (minimum 65%, Missing); tongue: 41.4286% (minimum 70%, Missing)",-0.103861,-0.285714,-0.374838,0,5,partial,48.3,41,24.1,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 3); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 3); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 3); thyroid gland: 12.8 nTPM (manageable, limit 5); colon: 12.3 nTPM (protected, limit 3); skin: 12.1 nTPM (manageable, limit 5); esophagus: 11.4 nTPM (protected, limit 3); salivary gland: 11.4 nTPM (protected, limit 3); adipose tissue: 11.3 nTPM (manageable, limit 10); bone marrow: 11 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); urinary bladder: 10.5 nTPM (protected, limit 3); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); lymph node: 9.3 nTPM (protected, limit 3); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148950,IMMP1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.7596% (minimum 75%, Baseline (adaptation disabled)); amygdala: 42.2125% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 39.3487% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 72.5000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 39.4022% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 44.8916% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 44.8223% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 53.3088% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 46.2520% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 49.4881% (minimum 75%, Baseline (adaptation disabled)); kidney: 52.3466% (minimum 75%, Baseline (adaptation disabled)); liver: 61.5711% (minimum 75%, Baseline (adaptation disabled)); midbrain: 52.5362% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.4444% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.7706% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 56.0928% (minimum 75%, Baseline (adaptation disabled)); retina: 44.2748% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 37.5162% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.7913% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.2016% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.3616% (minimum 70%, Baseline (adaptation disabled)); thymus: 54.6139% (minimum 65%, Baseline (adaptation disabled)); tongue: 41.4286% (minimum 70%, Baseline (adaptation disabled))",-0.103861,-0.285714,-0.374838,0,5,partial,48.3,41,24.1,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 3); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 3); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 3); thyroid gland: 12.8 nTPM (manageable, limit 5); colon: 12.3 nTPM (protected, limit 3); skin: 12.1 nTPM (manageable, limit 5); esophagus: 11.4 nTPM (protected, limit 3); salivary gland: 11.4 nTPM (protected, limit 3); adipose tissue: 11.3 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); urinary bladder: 10.5 nTPM (protected, limit 3); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); lymph node: 9.3 nTPM (protected, limit 3); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000148950,IMMP1L,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.0465% (minimum 95%, Missing); adrenal gland: 78.7234% (minimum 99%, Missing); amygdala: 82.2222% (minimum 99%, Missing); basal ganglia: 74.0000% (minimum 99%, Missing); cerebellum: 77.0833% (minimum 99%, Missing); cerebral cortex: 72.5490% (minimum 99%, Missing); choroid plexus: 69.8113% (minimum 99%, Missing); colon: 75.5102% (minimum 97%, Missing); duodenum: 88.0952% (minimum 99%, Missing); esophagus: 88.0952% (minimum 97%, Missing); heart muscle: 82.2222% (minimum 99%, Missing); hippocampal formation: 78.7234% (minimum 99%, Missing); hypothalamus: 77.0833% (minimum 99%, Missing); kidney: 61.6667% (minimum 99%, Missing); liver: 75.5102% (minimum 99%, Missing); lung: 75.5102% (minimum 99%, Missing); lymph node: 94.8718% (minimum 97%, Missing); midbrain: 86.0465% (minimum 99%, Missing); pancreas: 78.7234% (minimum 99%, Missing); parathyroid gland: 60.6557% (minimum 97%, Missing); pituitary gland: 74.0000% (minimum 99%, Missing); rectum: 78.7234% (minimum 97%, Missing); retina: 41.5730% (minimum 99%, Missing); salivary gland: 80.4348% (minimum 97%, Missing); skeletal muscle: 92.5000% (minimum 99%, Missing); skin: 92.5000% (minimum 95%, Missing); small intestine: 86.0465% (minimum 99%, Missing); smooth muscle: 68.5185% (minimum 99%, Missing); spinal cord: 84.0909% (minimum 99%, Missing); spleen: 94.8718% (minimum 95%, Missing); stomach: 86.0465% (minimum 97%, Missing); thymus: 94.8718% (minimum 95%, Missing); thyroid gland: 52.8571% (minimum 95%, Missing); tongue: 90.2439% (minimum 97%, Missing); urinary bladder: 72.5490% (minimum 97%, Missing)",-0.421429,-0.363443,-0.57427,0,80,unavailable,5.2,2.4,3.3,"retina: 5.2 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149050,ZNF214,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 74.0000% (minimum 75%, Missing); cerebral cortex: 72.5490% (minimum 75%, Missing); choroid plexus: 69.8113% (minimum 75%, Missing); kidney: 61.6667% (minimum 75%, Missing); parathyroid gland: 60.6557% (minimum 70%, Missing); pituitary gland: 74.0000% (minimum 75%, Missing); retina: 41.5730% (minimum 75%, Missing); smooth muscle: 68.5185% (minimum 75%, Missing); thyroid gland: 52.8571% (minimum 65%, Missing)",-0.121429,-0.0934426,-0.33427,0,80,unavailable,5.2,2.4,3.3,"retina: 5.2 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149050,ZNF214,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 74.0000% (minimum 75%, Missing); cerebral cortex: 72.5490% (minimum 75%, Missing); choroid plexus: 69.8113% (minimum 75%, Missing); kidney: 61.6667% (minimum 75%, Missing); parathyroid gland: 60.6557% (minimum 70%, Missing); pituitary gland: 74.0000% (minimum 75%, Missing); retina: 41.5730% (minimum 75%, Missing); smooth muscle: 68.5185% (minimum 75%, Missing); thyroid gland: 52.8571% (minimum 65%, Missing)",-0.121429,-0.0934426,-0.33427,0,80,unavailable,5.2,2.4,3.3,"retina: 5.2 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149050,ZNF214,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 74.0000% (minimum 75%, Missing); cerebral cortex: 72.5490% (minimum 75%, Missing); choroid plexus: 69.8113% (minimum 75%, Missing); kidney: 61.6667% (minimum 75%, Missing); parathyroid gland: 60.6557% (minimum 70%, Missing); pituitary gland: 74.0000% (minimum 75%, Missing); retina: 41.5730% (minimum 75%, Missing); smooth muscle: 68.5185% (minimum 75%, Missing); thyroid gland: 52.8571% (minimum 65%, Missing)",-0.121429,-0.0934426,-0.33427,0,80,unavailable,5.2,2.4,3.3,"retina: 5.2 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149050,ZNF214,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 74.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.5490% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.8113% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.6667% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.6557% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 74.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 41.5730% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.5185% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 52.8571% (minimum 65%, Baseline (adaptation disabled))",-0.121429,-0.0934426,-0.33427,0,80,unavailable,5.2,2.4,3.3,"retina: 5.2 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149050,ZNF214,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 78.9474% (minimum 95%, Enhanced); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 88.2353% (minimum 99%, Missing); bone marrow: 68.1818% (minimum 99%, Missing); cerebellum: 93.7500% (minimum 95%, Enhanced); cerebral cortex: 75.0000% (minimum 95%, Enhanced); choroid plexus: 93.7500% (minimum 99%, Missing); colon: 42.8571% (minimum 80%, Enhanced); duodenum: 41.6667% (minimum 95%, Enhanced); esophagus: 65.2174% (minimum 80%, Enhanced); heart muscle: 78.9474% (minimum 99%, Missing); hippocampal formation: 88.2353% (minimum 99%, Missing); hypothalamus: 71.4286% (minimum 99%, Missing); kidney: 60.0000% (minimum 95%, Enhanced); liver: 83.3333% (minimum 95%, Enhanced); lung: 75.0000% (minimum 99%, Missing); lymph node: 31.2500% (minimum 97%, Missing); midbrain: 93.7500% (minimum 99%, Missing); pancreas: 40.5405% (minimum 99%, Missing); pituitary gland: 88.2353% (minimum 99%, Missing); rectum: 37.5000% (minimum 80%, Enhanced); retina: 78.9474% (minimum 99%, Missing); salivary gland: 53.5714% (minimum 80%, Enhanced); skeletal muscle: 88.2353% (minimum 95%, Enhanced); skin: 75.0000% (minimum 95%, Missing); small intestine: 44.1176% (minimum 95%, Enhanced); smooth muscle: 75.0000% (minimum 99%, Missing); spinal cord: 93.7500% (minimum 99%, Missing); spleen: 48.3871% (minimum 95%, Missing); stomach: 68.1818% (minimum 80%, Enhanced); thymus: 57.6923% (minimum 95%, Missing); thyroid gland: 65.2174% (minimum 95%, Missing); tongue: 93.7500% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 80%, Enhanced)",-0.466129,-0.6575,-0.584595,0,2,partial,2.2,3.3,1.6,"lymph node: 3.3 nTPM (protected, limit 2); pancreas: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149054,ZNF215,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.1818% (minimum 75%, Missing); colon: 42.8571% (minimum 55%, Enhanced); duodenum: 41.6667% (minimum 60%, Enhanced); hypothalamus: 71.4286% (minimum 75%, Missing); lymph node: 31.2500% (minimum 70%, Missing); pancreas: 40.5405% (minimum 75%, Missing); rectum: 37.5000% (minimum 55%, Enhanced); salivary gland: 53.5714% (minimum 55%, Enhanced); small intestine: 44.1176% (minimum 60%, Enhanced); spleen: 48.3871% (minimum 65%, Missing); thymus: 57.6923% (minimum 65%, Missing)",-0.166129,-0.3875,-0.344595,0,2,partial,2.2,3.3,1.6,"lymph node: 3.3 nTPM (protected, limit 2); pancreas: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149054,ZNF215,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.1818% (minimum 75%, Missing); colon: 42.8571% (minimum 55%, Enhanced); duodenum: 41.6667% (minimum 60%, Enhanced); hypothalamus: 71.4286% (minimum 75%, Missing); lymph node: 31.2500% (minimum 70%, Missing); pancreas: 40.5405% (minimum 75%, Missing); rectum: 37.5000% (minimum 55%, Enhanced); salivary gland: 53.5714% (minimum 55%, Enhanced); small intestine: 44.1176% (minimum 60%, Enhanced); spleen: 48.3871% (minimum 65%, Missing); thymus: 57.6923% (minimum 65%, Missing)",-0.166129,-0.3875,-0.344595,0,2,partial,2.2,3.3,1.6,"lymph node: 3.3 nTPM (protected, limit 3); pancreas: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149054,ZNF215,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.1818% (minimum 75%, Missing); colon: 42.8571% (minimum 55%, Enhanced); duodenum: 41.6667% (minimum 60%, Enhanced); hypothalamus: 71.4286% (minimum 75%, Missing); lymph node: 31.2500% (minimum 70%, Missing); pancreas: 40.5405% (minimum 75%, Missing); rectum: 37.5000% (minimum 55%, Enhanced); salivary gland: 53.5714% (minimum 55%, Enhanced); small intestine: 44.1176% (minimum 60%, Enhanced); spleen: 48.3871% (minimum 65%, Missing); thymus: 57.6923% (minimum 65%, Missing)",-0.166129,-0.3875,-0.344595,0,2,partial,2.2,3.3,1.6,"lymph node: 3.3 nTPM (protected, limit 3); pancreas: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149054,ZNF215,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.1818% (minimum 75%, Baseline (adaptation disabled)); colon: 42.8571% (minimum 70%, Baseline (adaptation disabled)); duodenum: 41.6667% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.2174% (minimum 70%, Baseline (adaptation disabled)); hypothalamus: 71.4286% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 31.2500% (minimum 70%, Baseline (adaptation disabled)); pancreas: 40.5405% (minimum 75%, Baseline (adaptation disabled)); rectum: 37.5000% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 53.5714% (minimum 70%, Baseline (adaptation disabled)); small intestine: 44.1176% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.3871% (minimum 65%, Baseline (adaptation disabled)); stomach: 68.1818% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.6923% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 70%, Baseline (adaptation disabled))",-0.166129,-0.3875,-0.344595,0,2,partial,2.2,3.3,1.6,"lymph node: 3.3 nTPM (protected, limit 3); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149054,ZNF215,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.7798% (minimum 95%, Missing); adrenal gland: 76.8493% (minimum 99%, Missing); amygdala: 75.5047% (minimum 99%, Missing); basal ganglia: 64.6313% (minimum 99%, Missing); bone marrow: 76.0163% (minimum 99%, Missing); cerebellum: 88.7658% (minimum 99%, Missing); cerebral cortex: 73.7188% (minimum 99%, Missing); choroid plexus: 85.3881% (minimum 99%, Missing); colon: 91.0714% (minimum 97%, Missing); duodenum: 89.9038% (minimum 99%, Missing); esophagus: 86.7079% (minimum 97%, Missing); heart muscle: 91.5171% (minimum 99%, Missing); hippocampal formation: 82.5000% (minimum 99%, Missing); hypothalamus: 80.6034% (minimum 99%, Missing); kidney: 84.7432% (minimum 99%, Missing); liver: 88.4858% (minimum 99%, Missing); lung: 86.4407% (minimum 99%, Missing); lymph node: 70.2128% (minimum 97%, Missing); midbrain: 79.8009% (minimum 99%, Missing); pancreas: 94.9239% (minimum 99%, Missing); parathyroid gland: 69.1739% (minimum 97%, Missing); pituitary gland: 83.7313% (minimum 99%, Missing); rectum: 89.9038% (minimum 97%, Missing); retina: 71.1929% (minimum 99%, Missing); salivary gland: 85.3881% (minimum 97%, Missing); skeletal muscle: 91.6667% (minimum 99%, Missing); skin: 84.3609% (minimum 95%, Missing); small intestine: 82.2581% (minimum 99%, Missing); smooth muscle: 86.3077% (minimum 99%, Missing); spinal cord: 82.1376% (minimum 99%, Missing); spleen: 76.9547% (minimum 95%, Missing); stomach: 92.1182% (minimum 97%, Missing); thymus: 72.5744% (minimum 95%, Missing); thyroid gland: 72.6684% (minimum 95%, Missing); tongue: 81.5407% (minimum 97%, Missing); urinary bladder: 83.8565% (minimum 97%, Missing)",-0.224256,-0.278261,-0.343687,0,80,unavailable,30.7,25,21.2,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 2); lymph node: 23.8 nTPM (protected, limit 2); retina: 22.7 nTPM (vital, limit 1); thymus: 21.2 nTPM (manageable, limit 5); thyroid gland: 21.1 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); spleen: 16.8 nTPM (manageable, limit 5); midbrain: 14.2 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); kidney: 10.1 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 2); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); pancreas: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149212,SESN3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 64.6313% (minimum 75%, Missing); cerebral cortex: 73.7188% (minimum 75%, Missing); parathyroid gland: 69.1739% (minimum 70%, Missing); retina: 71.1929% (minimum 75%, Missing)",0.0757439,-0.00826141,-0.103687,0,80,unavailable,30.7,25,21.2,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 2); lymph node: 23.8 nTPM (protected, limit 2); retina: 22.7 nTPM (vital, limit 1); thymus: 21.2 nTPM (manageable, limit 5); thyroid gland: 21.1 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); spleen: 16.8 nTPM (manageable, limit 5); midbrain: 14.2 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); kidney: 10.1 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 2); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); pancreas: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149212,SESN3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 64.6313% (minimum 75%, Missing); cerebral cortex: 73.7188% (minimum 75%, Missing); parathyroid gland: 69.1739% (minimum 70%, Missing); retina: 71.1929% (minimum 75%, Missing)",0.0757439,-0.00826141,-0.103687,0,80,unavailable,30.7,25,21.2,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 3); lymph node: 23.8 nTPM (protected, limit 3); retina: 22.7 nTPM (vital, limit 1); thymus: 21.2 nTPM (manageable, limit 5); thyroid gland: 21.1 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); spleen: 16.8 nTPM (manageable, limit 5); midbrain: 14.2 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); kidney: 10.1 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 3); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 3); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); pancreas: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149212,SESN3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 64.6313% (minimum 75%, Missing); cerebral cortex: 73.7188% (minimum 75%, Missing); parathyroid gland: 69.1739% (minimum 70%, Missing); retina: 71.1929% (minimum 75%, Missing)",0.0757439,-0.00826141,-0.103687,0,80,unavailable,30.7,25,21.2,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 3); lymph node: 23.8 nTPM (protected, limit 3); retina: 22.7 nTPM (vital, limit 1); thymus: 21.2 nTPM (manageable, limit 5); thyroid gland: 21.1 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); spleen: 16.8 nTPM (manageable, limit 5); midbrain: 14.2 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); kidney: 10.1 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 3); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 3); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); pancreas: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149212,SESN3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 64.6313% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.7188% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.1739% (minimum 70%, Baseline (adaptation disabled)); retina: 71.1929% (minimum 75%, Baseline (adaptation disabled))",0.0757439,-0.00826141,-0.103687,0,80,unavailable,30.7,25,21.2,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 3); lymph node: 23.8 nTPM (protected, limit 3); retina: 22.7 nTPM (vital, limit 1); thymus: 21.2 nTPM (manageable, limit 5); thyroid gland: 21.1 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); spleen: 16.8 nTPM (manageable, limit 5); midbrain: 14.2 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); kidney: 10.1 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 3); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 3); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); pancreas: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149212,SESN3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.8367% (minimum 95%, Enhanced); amygdala: 71.4286% (minimum 99%, Missing); basal ganglia: 46.3918% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 95%, Enhanced); cerebral cortex: 64.2857% (minimum 95%, Enhanced); choroid plexus: 96.7742% (minimum 99%, Missing); heart muscle: 91.8367% (minimum 95%, Enhanced); hippocampal formation: 70.8661% (minimum 99%, Missing); hypothalamus: 60.8108% (minimum 99%, Missing); lung: 92.7835% (minimum 95%, Enhanced); midbrain: 77.5862% (minimum 99%, Missing); pancreas: 84.1121% (minimum 95%, Enhanced); pituitary gland: 90.9091% (minimum 99%, Missing); retina: 93.7500% (minimum 99%, Missing); spinal cord: 65.6934% (minimum 99%, Missing)",0.039011,0.00826087,-0.526082,0,3,partial,10.4,1.1,1.1,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149243,KLHL35,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 46.3918% (minimum 75%, Missing); hippocampal formation: 70.8661% (minimum 75%, Missing); hypothalamus: 60.8108% (minimum 75%, Missing); spinal cord: 65.6934% (minimum 75%, Missing)",0.339011,0.278261,-0.286082,0,3,partial,10.4,1.1,1.1,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149243,KLHL35,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 46.3918% (minimum 75%, Missing); hippocampal formation: 70.8661% (minimum 75%, Missing); hypothalamus: 60.8108% (minimum 75%, Missing); spinal cord: 65.6934% (minimum 75%, Missing)",0.339011,0.278261,-0.286082,0,3,partial,10.4,1.1,1.1,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149243,KLHL35,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 46.3918% (minimum 75%, Missing); hippocampal formation: 70.8661% (minimum 75%, Missing); hypothalamus: 60.8108% (minimum 75%, Missing); spinal cord: 65.6934% (minimum 75%, Missing)",0.339011,0.278261,-0.286082,0,3,partial,10.4,1.1,1.1,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149243,KLHL35,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 71.4286% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 46.3918% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.2857% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.8661% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.8108% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.6934% (minimum 75%, Baseline (adaptation disabled))",0.241089,0.191089,-0.286082,0,3,partial,10.4,1.1,1.1,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149243,KLHL35,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.4098% (minimum 90%, Approved); adrenal gland: 70.7692% (minimum 99%, Missing); amygdala: 70.7692% (minimum 99%, Missing); basal ganglia: 63.0137% (minimum 99%, Missing); bone marrow: 73.0159% (minimum 99%, Missing); cerebellum: 74.1935% (minimum 99%, Missing); cerebral cortex: 70.7692% (minimum 99%, Missing); choroid plexus: 76.6667% (minimum 99%, Missing); colon: 69.6970% (minimum 97%, Missing); duodenum: 71.8750% (minimum 99%, Missing); esophagus: 63.8889% (minimum 97%, Missing); heart muscle: 77.9661% (minimum 99%, Missing); hippocampal formation: 69.6970% (minimum 99%, Missing); hypothalamus: 64.7887% (minimum 99%, Missing); kidney: 63.0137% (minimum 99%, Missing); liver: 59.7403% (minimum 99%, Missing); lung: 76.6667% (minimum 99%, Missing); lymph node: 68.6567% (minimum 97%, Missing); midbrain: 67.6471% (minimum 99%, Missing); pancreas: 62.1622% (minimum 99%, Missing); parathyroid gland: 58.9744% (minimum 97%, Missing); pituitary gland: 50.0000% (minimum 99%, Missing); rectum: 67.6471% (minimum 97%, Missing); retina: 46.9388% (minimum 99%, Missing); salivary gland: 71.8750% (minimum 97%, Missing); skeletal muscle: 53.4884% (minimum 99%, Missing); skin: 56.0976% (minimum 95%, Missing); small intestine: 69.6970% (minimum 99%, Missing); smooth muscle: 82.1429% (minimum 99%, Missing); spinal cord: 63.8889% (minimum 99%, Missing); spleen: 64.7887% (minimum 90%, Approved); stomach: 67.6471% (minimum 97%, Missing); thymus: 64.7887% (minimum 95%, Missing); thyroid gland: 63.8889% (minimum 95%, Missing); tongue: 85.1852% (minimum 97%, Missing); urinary bladder: 74.1935% (minimum 97%, Missing)",-0.389024,-0.380256,-0.520612,0,1,partial,5.2,3.2,3.6,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149346,SLX4IP,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.7692% (minimum 75%, Missing); amygdala: 70.7692% (minimum 75%, Missing); basal ganglia: 63.0137% (minimum 75%, Missing); bone marrow: 73.0159% (minimum 75%, Missing); cerebellum: 74.1935% (minimum 75%, Missing); cerebral cortex: 70.7692% (minimum 75%, Missing); colon: 69.6970% (minimum 70%, Missing); duodenum: 71.8750% (minimum 75%, Missing); esophagus: 63.8889% (minimum 70%, Missing); hippocampal formation: 69.6970% (minimum 75%, Missing); hypothalamus: 64.7887% (minimum 75%, Missing); kidney: 63.0137% (minimum 75%, Missing); liver: 59.7403% (minimum 75%, Missing); lymph node: 68.6567% (minimum 70%, Missing); midbrain: 67.6471% (minimum 75%, Missing); pancreas: 62.1622% (minimum 75%, Missing); parathyroid gland: 58.9744% (minimum 70%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); rectum: 67.6471% (minimum 70%, Missing); retina: 46.9388% (minimum 75%, Missing); skeletal muscle: 53.4884% (minimum 75%, Missing); skin: 56.0976% (minimum 65%, Missing); small intestine: 69.6970% (minimum 75%, Missing); spinal cord: 63.8889% (minimum 75%, Missing); stomach: 67.6471% (minimum 70%, Missing); thymus: 64.7887% (minimum 65%, Missing); thyroid gland: 63.8889% (minimum 65%, Missing)",-0.0890244,-0.110256,-0.280612,0,1,partial,5.2,3.2,3.6,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149346,SLX4IP,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.7692% (minimum 75%, Missing); amygdala: 70.7692% (minimum 75%, Missing); basal ganglia: 63.0137% (minimum 75%, Missing); bone marrow: 73.0159% (minimum 75%, Missing); cerebellum: 74.1935% (minimum 75%, Missing); cerebral cortex: 70.7692% (minimum 75%, Missing); colon: 69.6970% (minimum 70%, Missing); duodenum: 71.8750% (minimum 75%, Missing); esophagus: 63.8889% (minimum 70%, Missing); hippocampal formation: 69.6970% (minimum 75%, Missing); hypothalamus: 64.7887% (minimum 75%, Missing); kidney: 63.0137% (minimum 75%, Missing); liver: 59.7403% (minimum 75%, Missing); lymph node: 68.6567% (minimum 70%, Missing); midbrain: 67.6471% (minimum 75%, Missing); pancreas: 62.1622% (minimum 75%, Missing); parathyroid gland: 58.9744% (minimum 70%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); rectum: 67.6471% (minimum 70%, Missing); retina: 46.9388% (minimum 75%, Missing); skeletal muscle: 53.4884% (minimum 75%, Missing); skin: 56.0976% (minimum 65%, Missing); small intestine: 69.6970% (minimum 75%, Missing); spinal cord: 63.8889% (minimum 75%, Missing); stomach: 67.6471% (minimum 70%, Missing); thymus: 64.7887% (minimum 65%, Missing); thyroid gland: 63.8889% (minimum 65%, Missing)",-0.0890244,-0.110256,-0.280612,0,1,partial,5.2,3.2,3.6,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149346,SLX4IP,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.7692% (minimum 75%, Missing); amygdala: 70.7692% (minimum 75%, Missing); basal ganglia: 63.0137% (minimum 75%, Missing); bone marrow: 73.0159% (minimum 75%, Missing); cerebellum: 74.1935% (minimum 75%, Missing); cerebral cortex: 70.7692% (minimum 75%, Missing); colon: 69.6970% (minimum 70%, Missing); duodenum: 71.8750% (minimum 75%, Missing); esophagus: 63.8889% (minimum 70%, Missing); hippocampal formation: 69.6970% (minimum 75%, Missing); hypothalamus: 64.7887% (minimum 75%, Missing); kidney: 63.0137% (minimum 75%, Missing); liver: 59.7403% (minimum 75%, Missing); lymph node: 68.6567% (minimum 70%, Missing); midbrain: 67.6471% (minimum 75%, Missing); pancreas: 62.1622% (minimum 75%, Missing); parathyroid gland: 58.9744% (minimum 70%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); rectum: 67.6471% (minimum 70%, Missing); retina: 46.9388% (minimum 75%, Missing); skeletal muscle: 53.4884% (minimum 75%, Missing); skin: 56.0976% (minimum 65%, Missing); small intestine: 69.6970% (minimum 75%, Missing); spinal cord: 63.8889% (minimum 75%, Missing); stomach: 67.6471% (minimum 70%, Missing); thymus: 64.7887% (minimum 65%, Missing); thyroid gland: 63.8889% (minimum 65%, Missing)",-0.0890244,-0.110256,-0.280612,0,1,partial,5.2,3.2,3.6,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149346,SLX4IP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.7692% (minimum 75%, Baseline (adaptation disabled)); amygdala: 70.7692% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 63.0137% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 73.0159% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.1935% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.7692% (minimum 75%, Baseline (adaptation disabled)); colon: 69.6970% (minimum 70%, Baseline (adaptation disabled)); duodenum: 71.8750% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.8889% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 69.6970% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.7887% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.0137% (minimum 75%, Baseline (adaptation disabled)); liver: 59.7403% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.6567% (minimum 70%, Baseline (adaptation disabled)); midbrain: 67.6471% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.1622% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.9744% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); rectum: 67.6471% (minimum 70%, Baseline (adaptation disabled)); retina: 46.9388% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 53.4884% (minimum 75%, Baseline (adaptation disabled)); skin: 56.0976% (minimum 65%, Baseline (adaptation disabled)); small intestine: 69.6970% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.8889% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.7887% (minimum 65%, Baseline (adaptation disabled)); stomach: 67.6471% (minimum 70%, Baseline (adaptation disabled)); thymus: 64.7887% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 63.8889% (minimum 65%, Baseline (adaptation disabled))",-0.0890244,-0.110256,-0.280612,0,1,partial,5.2,3.2,3.6,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149346,SLX4IP,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149507,OOSP2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149507,OOSP2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149507,OOSP2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149507,OOSP2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149507,OOSP2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.5780% (minimum 95%, Missing); adrenal gland: 97.1429% (minimum 99%, Missing); amygdala: 96.2264% (minimum 99%, Missing); basal ganglia: 97.1429% (minimum 99%, Missing); bone marrow: 82.9268% (minimum 99%, Missing); cerebellum: 98.0769% (minimum 99%, Missing); cerebral cortex: 96.2264% (minimum 99%, Missing); choroid plexus: 97.1429% (minimum 99%, Missing); colon: 93.5780% (minimum 97%, Missing); duodenum: 93.5780% (minimum 99%, Missing); esophagus: 92.7273% (minimum 97%, Missing); heart muscle: 98.0769% (minimum 99%, Missing); hippocampal formation: 97.1429% (minimum 99%, Missing); hypothalamus: 97.1429% (minimum 99%, Missing); kidney: 94.4444% (minimum 99%, Missing); liver: 88.6957% (minimum 99%, Missing); lung: 93.5780% (minimum 99%, Missing); lymph node: 89.4737% (minimum 97%, Missing); midbrain: 96.2264% (minimum 99%, Missing); pancreas: 92.7273% (minimum 99%, Missing); parathyroid gland: 94.4444% (minimum 97%, Missing); pituitary gland: 95.3271% (minimum 99%, Missing); rectum: 92.7273% (minimum 97%, Missing); retina: 86.4407% (minimum 99%, Missing); salivary gland: 72.8571% (minimum 97%, Missing); skin: 82.9268% (minimum 95%, Missing); small intestine: 94.4444% (minimum 99%, Missing); smooth muscle: 94.4444% (minimum 99%, Missing); spinal cord: 95.3271% (minimum 99%, Missing); spleen: 92.7273% (minimum 95%, Missing); stomach: 94.4444% (minimum 97%, Missing); thymus: 79.0698% (minimum 95%, Missing); thyroid gland: 94.4444% (minimum 95%, Missing); urinary bladder: 95.3271% (minimum 97%, Missing)",-0.159302,-0.241429,-0.160732,0,80,unavailable,2.1,3.8,2.7,"salivary gland: 3.8 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149548,CCDC15,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.140698,0.0285714,0.0792683,0,80,unavailable,2.1,3.8,2.7,"salivary gland: 3.8 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149548,CCDC15,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.140698,0.0285714,0.0792683,0,80,unavailable,2.1,3.8,2.7,"salivary gland: 3.8 nTPM (protected, limit 3); bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149548,CCDC15,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.140698,0.0285714,0.0792683,0,80,unavailable,2.1,3.8,2.7,"salivary gland: 3.8 nTPM (protected, limit 3); bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149548,CCDC15,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.140698,0.0285714,0.0792683,0,80,unavailable,2.1,3.8,2.7,"salivary gland: 3.8 nTPM (protected, limit 3); bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149548,CCDC15,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.5338% (minimum 95%, Missing); adrenal gland: 96.0784% (minimum 99%, Missing); amygdala: 96.0784% (minimum 99%, Missing); basal ganglia: 95.4545% (minimum 99%, Missing); bone marrow: 53.0686% (minimum 99%, Missing); cerebellum: 98.0000% (minimum 99%, Missing); cerebral cortex: 96.3934% (minimum 99%, Missing); colon: 78.6096% (minimum 97%, Missing); duodenum: 81.6667% (minimum 99%, Missing); esophagus: 87.5000% (minimum 97%, Missing); heart muscle: 97.0297% (minimum 99%, Missing); hippocampal formation: 96.0784% (minimum 99%, Missing); hypothalamus: 96.0784% (minimum 99%, Missing); kidney: 92.7445% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); lung: 95.7655% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 94.8387% (minimum 99%, Missing); pancreas: 93.9297% (minimum 99%, Missing); parathyroid gland: 69.6682% (minimum 97%, Missing); pituitary gland: 94.8387% (minimum 99%, Missing); rectum: 77.3684% (minimum 97%, Missing); retina: 97.0297% (minimum 99%, Missing); salivary gland: 95.1456% (minimum 97%, Missing); skeletal muscle: 98.0000% (minimum 99%, Missing); skin: 89.3617% (minimum 95%, Missing); small intestine: 80.1090% (minimum 99%, Missing); smooth muscle: 89.9083% (minimum 99%, Missing); spinal cord: 95.4545% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Missing); stomach: 91.3043% (minimum 97%, Missing); thymus: 59.0361% (minimum 95%, Missing); tongue: 96.0784% (minimum 97%, Missing); urinary bladder: 89.9083% (minimum 97%, Missing)",-0.359639,-0.303333,-0.459314,0,80,unavailable,26,14.7,20.4,"bone marrow: 26 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 2); parathyroid gland: 12.8 nTPM (protected, limit 2); rectum: 8.6 nTPM (protected, limit 2); colon: 8 nTPM (protected, limit 2); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149554,CHEK1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 53.0686% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); parathyroid gland: 69.6682% (minimum 70%, Missing); thymus: 59.0361% (minimum 65%, Missing)",-0.0596386,-0.0333333,-0.219314,0,80,unavailable,26,14.7,20.4,"bone marrow: 26 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 2); parathyroid gland: 12.8 nTPM (protected, limit 2); rectum: 8.6 nTPM (protected, limit 2); colon: 8 nTPM (protected, limit 2); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149554,CHEK1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 53.0686% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); parathyroid gland: 69.6682% (minimum 70%, Missing); thymus: 59.0361% (minimum 65%, Missing)",-0.0596386,-0.0333333,-0.219314,0,80,unavailable,26,14.7,20.4,"bone marrow: 26 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 3); parathyroid gland: 12.8 nTPM (protected, limit 3); rectum: 8.6 nTPM (protected, limit 3); colon: 8 nTPM (protected, limit 3); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149554,CHEK1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 53.0686% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); parathyroid gland: 69.6682% (minimum 70%, Missing); thymus: 59.0361% (minimum 65%, Missing)",-0.0596386,-0.0333333,-0.219314,0,80,unavailable,26,14.7,20.4,"bone marrow: 26 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 3); parathyroid gland: 12.8 nTPM (protected, limit 3); rectum: 8.6 nTPM (protected, limit 3); colon: 8 nTPM (protected, limit 3); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149554,CHEK1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 53.0686% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 69.6682% (minimum 70%, Baseline (adaptation disabled)); thymus: 59.0361% (minimum 65%, Baseline (adaptation disabled))",-0.0596386,-0.0333333,-0.219314,0,80,unavailable,26,14.7,20.4,"bone marrow: 26 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 3); parathyroid gland: 12.8 nTPM (protected, limit 3); rectum: 8.6 nTPM (protected, limit 3); colon: 8 nTPM (protected, limit 3); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149554,CHEK1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149609,C20orf144,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149609,C20orf144,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149609,C20orf144,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149609,C20orf144,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149609,C20orf144,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.3043% (minimum 95%, Missing); adrenal gland: 85.4237% (minimum 99%, Missing); amygdala: 86.3014% (minimum 99%, Missing); basal ganglia: 84.8485% (minimum 99%, Missing); bone marrow: 74.3363% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); cerebral cortex: 86.8966% (minimum 99%, Missing); choroid plexus: 79.7468% (minimum 99%, Missing); colon: 86.0068% (minimum 97%, Missing); duodenum: 87.1972% (minimum 99%, Missing); esophagus: 89.3617% (minimum 97%, Missing); heart muscle: 86.8966% (minimum 99%, Missing); hippocampal formation: 86.5979% (minimum 99%, Missing); hypothalamus: 85.1351% (minimum 99%, Missing); kidney: 77.0642% (minimum 99%, Missing); liver: 82.3529% (minimum 99%, Missing); lung: 91.6364% (minimum 99%, Missing); lymph node: 86.3014% (minimum 97%, Missing); midbrain: 85.4237% (minimum 99%, Missing); pancreas: 78.7500% (minimum 99%, Missing); parathyroid gland: 82.0847% (minimum 97%, Missing); pituitary gland: 84.0000% (minimum 99%, Missing); rectum: 90.3226% (minimum 97%, Missing); retina: 62.2222% (minimum 99%, Missing); salivary gland: 86.3014% (minimum 97%, Missing); skeletal muscle: 52.3909% (minimum 99%, Missing); skin: 81.8182% (minimum 95%, Missing); small intestine: 84.8485% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spinal cord: 88.4211% (minimum 99%, Missing); spleen: 81.8182% (minimum 95%, Missing); stomach: 87.1972% (minimum 97%, Missing); thymus: 85.7143% (minimum 95%, Missing); thyroid gland: 84.8485% (minimum 95%, Missing); tongue: 61.0169% (minimum 97%, Missing); urinary bladder: 90.3226% (minimum 97%, Missing)",-0.131818,-0.359831,-0.466091,0,6,partial,22.9,16.1,5.6,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 2); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 2); salivary gland: 4 nTPM (protected, limit 2); lymph node: 4 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); urinary bladder: 2.7 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149646,CNBD2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 74.3363% (minimum 75%, Missing); retina: 62.2222% (minimum 75%, Missing); skeletal muscle: 52.3909% (minimum 75%, Missing); tongue: 61.0169% (minimum 70%, Missing)",0.168182,-0.0898305,-0.226091,0,6,partial,22.9,16.1,5.6,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 2); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 2); salivary gland: 4 nTPM (protected, limit 2); lymph node: 4 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); urinary bladder: 2.7 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149646,CNBD2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 74.3363% (minimum 75%, Missing); retina: 62.2222% (minimum 75%, Missing); skeletal muscle: 52.3909% (minimum 75%, Missing); tongue: 61.0169% (minimum 70%, Missing)",0.168182,-0.0898305,-0.226091,0,6,partial,22.9,16.1,5.6,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); skin: 5.6 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 3); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 3); amygdala: 4 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 3); lymph node: 4 nTPM (protected, limit 3); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149646,CNBD2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 74.3363% (minimum 75%, Missing); retina: 62.2222% (minimum 75%, Missing); skeletal muscle: 52.3909% (minimum 75%, Missing); tongue: 61.0169% (minimum 70%, Missing)",0.168182,-0.0898305,-0.226091,0,6,partial,22.9,16.1,5.6,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); skin: 5.6 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 3); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 3); amygdala: 4 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 3); lymph node: 4 nTPM (protected, limit 3); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149646,CNBD2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 74.3363% (minimum 75%, Baseline (adaptation disabled)); retina: 62.2222% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 52.3909% (minimum 75%, Baseline (adaptation disabled)); tongue: 61.0169% (minimum 70%, Baseline (adaptation disabled))",0.168182,-0.0898305,-0.226091,0,6,partial,22.9,16.1,5.6,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); skin: 5.6 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 3); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 3); amygdala: 4 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 3); lymph node: 4 nTPM (protected, limit 3); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149646,CNBD2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.00633834,0,2,partial,1,0,0,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland / glandular cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / non-germinal center cells,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000149651,SPINT4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.246338,0,2,partial,1,0,0,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland / glandular cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / non-germinal center cells,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000149651,SPINT4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.246338,0,2,partial,1,0,0,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland / glandular cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / non-germinal center cells,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000149651,SPINT4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.246338,0,2,partial,1,0,0,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland / glandular cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / non-germinal center cells,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000149651,SPINT4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.246338,0,2,partial,1,0,0,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland / glandular cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / non-germinal center cells,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000149651,SPINT4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.9231% (minimum 95%, Missing); adrenal gland: 91.2387% (minimum 99%, Missing); amygdala: 87.7907% (minimum 99%, Missing); basal ganglia: 88.5630% (minimum 99%, Missing); bone marrow: 79.0576% (minimum 99%, Missing); cerebellum: 68.6364% (minimum 99%, Missing); cerebral cortex: 77.8351% (minimum 99%, Missing); choroid plexus: 93.4985% (minimum 99%, Missing); colon: 87.7907% (minimum 97%, Missing); duodenum: 91.5152% (minimum 99%, Missing); esophagus: 90.6907% (minimum 97%, Missing); heart muscle: 74.7525% (minimum 99%, Missing); hippocampal formation: 88.0466% (minimum 99%, Missing); hypothalamus: 85.5524% (minimum 99%, Missing); kidney: 92.3547% (minimum 99%, Missing); liver: 88.5630% (minimum 99%, Missing); lung: 91.5152% (minimum 99%, Missing); lymph node: 86.0399% (minimum 97%, Missing); midbrain: 89.0855% (minimum 99%, Missing); pancreas: 90.6907% (minimum 99%, Missing); parathyroid gland: 89.0855% (minimum 97%, Missing); pituitary gland: 84.1226% (minimum 99%, Missing); rectum: 90.6907% (minimum 97%, Missing); retina: 84.5938% (minimum 99%, Missing); salivary gland: 90.4192% (minimum 97%, Missing); skeletal muscle: 84.3575% (minimum 99%, Missing); skin: 87.7907% (minimum 95%, Missing); small intestine: 87.5362% (minimum 99%, Missing); smooth muscle: 90.4192% (minimum 99%, Missing); spinal cord: 89.6142% (minimum 99%, Missing); spleen: 88.0466% (minimum 95%, Missing); stomach: 88.8235% (minimum 97%, Missing); thymus: 85.3107% (minimum 95%, Missing); thyroid gland: 85.7955% (minimum 95%, Missing); tongue: 88.5630% (minimum 97%, Missing); urinary bladder: 89.3491% (minimum 97%, Missing)",-0.0968927,-0.109601,-0.303636,0,80,unavailable,13.8,4.9,5.2,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.1 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); basal ganglia: 3.9 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); midbrain: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); urinary bladder: 3.6 nTPM (protected, limit 2); spinal cord: 3.5 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149679,CABLES2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 68.6364% (minimum 75%, Missing); heart muscle: 74.7525% (minimum 75%, Missing)",0.203107,0.160399,-0.0636364,0,80,unavailable,13.8,4.9,5.2,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.1 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); basal ganglia: 3.9 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); midbrain: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); urinary bladder: 3.6 nTPM (protected, limit 2); spinal cord: 3.5 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149679,CABLES2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 68.6364% (minimum 75%, Missing); heart muscle: 74.7525% (minimum 75%, Missing)",0.203107,0.160399,-0.0636364,0,80,unavailable,13.8,4.9,5.2,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.1 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); basal ganglia: 3.9 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); midbrain: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); urinary bladder: 3.6 nTPM (protected, limit 3); spinal cord: 3.5 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149679,CABLES2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 68.6364% (minimum 75%, Missing); heart muscle: 74.7525% (minimum 75%, Missing)",0.203107,0.160399,-0.0636364,0,80,unavailable,13.8,4.9,5.2,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.1 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); basal ganglia: 3.9 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); midbrain: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); urinary bladder: 3.6 nTPM (protected, limit 3); spinal cord: 3.5 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149679,CABLES2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 68.6364% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 74.7525% (minimum 75%, Baseline (adaptation disabled))",0.203107,0.160399,-0.0636364,0,80,unavailable,13.8,4.9,5.2,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.1 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); basal ganglia: 3.9 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); midbrain: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); urinary bladder: 3.6 nTPM (protected, limit 3); spinal cord: 3.5 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149679,CABLES2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.1696% (minimum 99%, Missing); amygdala: 80.6171% (minimum 99%, Missing); basal ganglia: 82.3767% (minimum 99%, Missing); bone marrow: 98.8361% (minimum 99%, Missing); cerebellum: 54.4629% (minimum 99%, Missing); cerebral cortex: 70.8131% (minimum 99%, Missing); choroid plexus: 98.8361% (minimum 99%, Missing); hippocampal formation: 76.8477% (minimum 99%, Missing); hypothalamus: 84.6346% (minimum 99%, Missing); midbrain: 86.5760% (minimum 99%, Missing); pituitary gland: 82.9805% (minimum 99%, Missing); retina: 60.7633% (minimum 99%, Missing); skeletal muscle: 90.1770% (minimum 99%, Missing); spinal cord: 91.2265% (minimum 99%, Missing)",0.0393204,0.0145411,-0.445371,0,80,unavailable,85.2,1.6,1.1,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149926,TLCD3B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 54.4629% (minimum 75%, Missing); cerebral cortex: 70.8131% (minimum 75%, Missing); retina: 60.7633% (minimum 75%, Missing)",0.33932,0.284541,-0.205371,0,80,unavailable,85.2,1.6,1.1,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149926,TLCD3B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 54.4629% (minimum 75%, Missing); cerebral cortex: 70.8131% (minimum 75%, Missing); retina: 60.7633% (minimum 75%, Missing)",0.33932,0.284541,-0.205371,0,80,unavailable,85.2,1.6,1.1,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149926,TLCD3B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 54.4629% (minimum 75%, Missing); cerebral cortex: 70.8131% (minimum 75%, Missing); retina: 60.7633% (minimum 75%, Missing)",0.33932,0.284541,-0.205371,0,80,unavailable,85.2,1.6,1.1,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149926,TLCD3B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 54.4629% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.8131% (minimum 75%, Baseline (adaptation disabled)); retina: 60.7633% (minimum 75%, Baseline (adaptation disabled))",0.33932,0.284541,-0.205371,0,80,unavailable,85.2,1.6,1.1,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149926,TLCD3B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 97.3684% (minimum 99%, Missing); bone marrow: 43.5294% (minimum 99%, Missing); cerebral cortex: 97.3684% (minimum 99%, Missing); choroid plexus: 97.3684% (minimum 99%, Missing); colon: 64.9123% (minimum 97%, Missing); duodenum: 74.0000% (minimum 99%, Missing); esophagus: 92.5000% (minimum 97%, Missing); heart muscle: 97.3684% (minimum 99%, Missing); kidney: 94.8718% (minimum 99%, Missing); liver: 94.8718% (minimum 99%, Missing); lung: 97.3684% (minimum 99%, Missing); pancreas: 80.4348% (minimum 99%, Missing); pituitary gland: 90.2439% (minimum 99%, Missing); rectum: 61.6667% (minimum 97%, Missing); retina: 88.0952% (minimum 99%, Missing); skeletal muscle: 69.8113% (minimum 99%, Missing); skin: 90.2439% (minimum 95%, Missing); small intestine: 78.7234% (minimum 99%, Missing); smooth muscle: 97.3684% (minimum 99%, Missing); stomach: 77.0833% (minimum 97%, Missing); thymus: 94.8718% (minimum 95%, Missing); thyroid gland: 86.0465% (minimum 95%, Missing); tongue: 94.8718% (minimum 97%, Missing)",-0.0895349,-0.353333,-0.554706,0,4,partial,4.8,2.3,0.6,"bone marrow: 4.8 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149948,HMGA2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 43.5294% (minimum 75%, Missing); colon: 64.9123% (minimum 70%, Missing); duodenum: 74.0000% (minimum 75%, Missing); rectum: 61.6667% (minimum 70%, Missing); skeletal muscle: 69.8113% (minimum 75%, Missing)",0.210465,-0.0833333,-0.314706,0,4,partial,4.8,2.3,0.6,"bone marrow: 4.8 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149948,HMGA2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 43.5294% (minimum 75%, Missing); colon: 64.9123% (minimum 70%, Missing); duodenum: 74.0000% (minimum 75%, Missing); rectum: 61.6667% (minimum 70%, Missing); skeletal muscle: 69.8113% (minimum 75%, Missing)",0.210465,-0.0833333,-0.314706,0,4,partial,4.8,2.3,0.6,"bone marrow: 4.8 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149948,HMGA2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 43.5294% (minimum 75%, Missing); colon: 64.9123% (minimum 70%, Missing); duodenum: 74.0000% (minimum 75%, Missing); rectum: 61.6667% (minimum 70%, Missing); skeletal muscle: 69.8113% (minimum 75%, Missing)",0.210465,-0.0833333,-0.314706,0,4,partial,4.8,2.3,0.6,"bone marrow: 4.8 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149948,HMGA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 43.5294% (minimum 75%, Baseline (adaptation disabled)); colon: 64.9123% (minimum 70%, Baseline (adaptation disabled)); duodenum: 74.0000% (minimum 75%, Baseline (adaptation disabled)); rectum: 61.6667% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 69.8113% (minimum 75%, Baseline (adaptation disabled))",0.210465,-0.0833333,-0.314706,0,4,partial,4.8,2.3,0.6,"bone marrow: 4.8 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000149948,HMGA2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150244,TRIM48,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150244,TRIM48,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150244,TRIM48,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150244,TRIM48,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150244,TRIM48,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 14.8148% (minimum 99%, Missing); amygdala: 32.0000% (minimum 99%, Missing); basal ganglia: 47.7612% (minimum 99%, Missing); bone marrow: 96.9697% (minimum 99%, Missing); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 32.6531% (minimum 99%, Missing); choroid plexus: 94.1176% (minimum 99%, Missing); colon: 96.9697% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); esophagus: 96.9697% (minimum 97%, Missing); heart muscle: 86.4865% (minimum 99%, Missing); hippocampal formation: 35.1648% (minimum 99%, Missing); hypothalamus: 38.5542% (minimum 99%, Missing); kidney: 29.3578% (minimum 99%, Missing); lung: 57.1429% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); midbrain: 38.5542% (minimum 99%, Missing); parathyroid gland: 86.4865% (minimum 97%, Missing); pituitary gland: 41.0256% (minimum 99%, Missing); retina: 5.0713% (minimum 99%, Missing); salivary gland: 96.9697% (minimum 97%, Missing); small intestine: 94.1176% (minimum 99%, Missing); spinal cord: 53.3333% (minimum 99%, Missing); spleen: 82.0513% (minimum 95%, Missing); stomach: 91.4286% (minimum 97%, Missing); urinary bladder: 88.8889% (minimum 97%, Missing)",-0.129487,-0.105135,-0.939287,0,80,unavailable,59.9,0.5,0.7,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150275,PCDH15,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 14.8148% (minimum 75%, Missing); amygdala: 32.0000% (minimum 75%, Missing); basal ganglia: 47.7612% (minimum 75%, Missing); cerebral cortex: 32.6531% (minimum 75%, Missing); hippocampal formation: 35.1648% (minimum 75%, Missing); hypothalamus: 38.5542% (minimum 75%, Missing); kidney: 29.3578% (minimum 75%, Missing); lung: 57.1429% (minimum 75%, Missing); midbrain: 38.5542% (minimum 75%, Missing); pituitary gland: 41.0256% (minimum 75%, Missing); retina: 5.0713% (minimum 75%, Missing); spinal cord: 53.3333% (minimum 75%, Missing)",0.170513,0.164865,-0.699287,0,80,unavailable,59.9,0.5,0.7,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150275,PCDH15,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 14.8148% (minimum 75%, Missing); amygdala: 32.0000% (minimum 75%, Missing); basal ganglia: 47.7612% (minimum 75%, Missing); cerebral cortex: 32.6531% (minimum 75%, Missing); hippocampal formation: 35.1648% (minimum 75%, Missing); hypothalamus: 38.5542% (minimum 75%, Missing); kidney: 29.3578% (minimum 75%, Missing); lung: 57.1429% (minimum 75%, Missing); midbrain: 38.5542% (minimum 75%, Missing); pituitary gland: 41.0256% (minimum 75%, Missing); retina: 5.0713% (minimum 75%, Missing); spinal cord: 53.3333% (minimum 75%, Missing)",0.170513,0.164865,-0.699287,0,80,unavailable,59.9,0.5,0.7,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150275,PCDH15,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 14.8148% (minimum 75%, Missing); amygdala: 32.0000% (minimum 75%, Missing); basal ganglia: 47.7612% (minimum 75%, Missing); cerebral cortex: 32.6531% (minimum 75%, Missing); hippocampal formation: 35.1648% (minimum 75%, Missing); hypothalamus: 38.5542% (minimum 75%, Missing); kidney: 29.3578% (minimum 75%, Missing); lung: 57.1429% (minimum 75%, Missing); midbrain: 38.5542% (minimum 75%, Missing); pituitary gland: 41.0256% (minimum 75%, Missing); retina: 5.0713% (minimum 75%, Missing); spinal cord: 53.3333% (minimum 75%, Missing)",0.170513,0.164865,-0.699287,0,80,unavailable,59.9,0.5,0.7,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150275,PCDH15,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 14.8148% (minimum 75%, Baseline (adaptation disabled)); amygdala: 32.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 47.7612% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 32.6531% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 35.1648% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 38.5542% (minimum 75%, Baseline (adaptation disabled)); kidney: 29.3578% (minimum 75%, Baseline (adaptation disabled)); lung: 57.1429% (minimum 75%, Baseline (adaptation disabled)); midbrain: 38.5542% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 41.0256% (minimum 75%, Baseline (adaptation disabled)); retina: 5.0713% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.3333% (minimum 75%, Baseline (adaptation disabled))",0.170513,0.164865,-0.699287,0,80,unavailable,59.9,0.5,0.7,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150275,PCDH15,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.6330% (minimum 95%, Missing); adrenal gland: 60.1852% (minimum 99%, Missing); amygdala: 77.3810% (minimum 99%, Missing); basal ganglia: 76.4706% (minimum 99%, Missing); bone marrow: 77.3810% (minimum 99%, Missing); cerebellum: 71.4286% (minimum 99%, Missing); cerebral cortex: 69.8925% (minimum 99%, Missing); choroid plexus: 63.7255% (minimum 99%, Missing); colon: 54.1667% (minimum 97%, Missing); duodenum: 45.7746% (minimum 99%, Missing); esophagus: 57.5221% (minimum 97%, Missing); heart muscle: 51.1811% (minimum 99%, Missing); hippocampal formation: 80.2469% (minimum 99%, Missing); hypothalamus: 73.0337% (minimum 99%, Missing); kidney: 61.9048% (minimum 99%, Missing); liver: 49.6183% (minimum 99%, Missing); lung: 63.1068% (minimum 99%, Missing); lymph node: 63.1068% (minimum 97%, Missing); midbrain: 73.0337% (minimum 99%, Missing); pancreas: 51.5873% (minimum 99%, Missing); parathyroid gland: 49.6183% (minimum 97%, Missing); pituitary gland: 65.0000% (minimum 99%, Missing); rectum: 54.1667% (minimum 97%, Missing); retina: 68.4211% (minimum 99%, Missing); salivary gland: 44.8276% (minimum 97%, Missing); skeletal muscle: 58.0357% (minimum 99%, Missing); skin: 61.9048% (minimum 95%, Missing); small intestine: 45.1389% (minimum 99%, Missing); smooth muscle: 58.0357% (minimum 99%, Missing); spinal cord: 81.2500% (minimum 99%, Missing); spleen: 58.5586% (minimum 95%, Missing); stomach: 63.1068% (minimum 97%, Missing); thymus: 67.7083% (minimum 95%, Missing); thyroid gland: 56.0345% (minimum 95%, Missing); tongue: 57.0175% (minimum 97%, Missing); urinary bladder: 59.6330% (minimum 97%, Missing)",-0.389655,-0.521724,-0.538611,0,80,unavailable,7.9,8,5.1,"salivary gland: 8 nTPM (protected, limit 2); small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); thyroid gland: 5.1 nTPM (manageable, limit 5); tongue: 4.9 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); lymph node: 3.8 nTPM (protected, limit 2); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150455,TIRAP,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.6330% (minimum 65%, Missing); adrenal gland: 60.1852% (minimum 75%, Missing); cerebellum: 71.4286% (minimum 75%, Missing); cerebral cortex: 69.8925% (minimum 75%, Missing); choroid plexus: 63.7255% (minimum 75%, Missing); colon: 54.1667% (minimum 70%, Missing); duodenum: 45.7746% (minimum 75%, Missing); esophagus: 57.5221% (minimum 70%, Missing); heart muscle: 51.1811% (minimum 75%, Missing); hypothalamus: 73.0337% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 49.6183% (minimum 75%, Missing); lung: 63.1068% (minimum 75%, Missing); lymph node: 63.1068% (minimum 70%, Missing); midbrain: 73.0337% (minimum 75%, Missing); pancreas: 51.5873% (minimum 75%, Missing); parathyroid gland: 49.6183% (minimum 70%, Missing); pituitary gland: 65.0000% (minimum 75%, Missing); rectum: 54.1667% (minimum 70%, Missing); retina: 68.4211% (minimum 75%, Missing); salivary gland: 44.8276% (minimum 70%, Missing); skeletal muscle: 58.0357% (minimum 75%, Missing); skin: 61.9048% (minimum 65%, Missing); small intestine: 45.1389% (minimum 75%, Missing); smooth muscle: 58.0357% (minimum 75%, Missing); spleen: 58.5586% (minimum 65%, Missing); stomach: 63.1068% (minimum 70%, Missing); thyroid gland: 56.0345% (minimum 65%, Missing); tongue: 57.0175% (minimum 70%, Missing); urinary bladder: 59.6330% (minimum 70%, Missing)",-0.0896552,-0.251724,-0.298611,0,80,unavailable,7.9,8,5.1,"salivary gland: 8 nTPM (protected, limit 2); small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); thyroid gland: 5.1 nTPM (manageable, limit 5); tongue: 4.9 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); lymph node: 3.8 nTPM (protected, limit 2); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150455,TIRAP,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.6330% (minimum 65%, Missing); adrenal gland: 60.1852% (minimum 75%, Missing); cerebellum: 71.4286% (minimum 75%, Missing); cerebral cortex: 69.8925% (minimum 75%, Missing); choroid plexus: 63.7255% (minimum 75%, Missing); colon: 54.1667% (minimum 70%, Missing); duodenum: 45.7746% (minimum 75%, Missing); esophagus: 57.5221% (minimum 70%, Missing); heart muscle: 51.1811% (minimum 75%, Missing); hypothalamus: 73.0337% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 49.6183% (minimum 75%, Missing); lung: 63.1068% (minimum 75%, Missing); lymph node: 63.1068% (minimum 70%, Missing); midbrain: 73.0337% (minimum 75%, Missing); pancreas: 51.5873% (minimum 75%, Missing); parathyroid gland: 49.6183% (minimum 70%, Missing); pituitary gland: 65.0000% (minimum 75%, Missing); rectum: 54.1667% (minimum 70%, Missing); retina: 68.4211% (minimum 75%, Missing); salivary gland: 44.8276% (minimum 70%, Missing); skeletal muscle: 58.0357% (minimum 75%, Missing); skin: 61.9048% (minimum 65%, Missing); small intestine: 45.1389% (minimum 75%, Missing); smooth muscle: 58.0357% (minimum 75%, Missing); spleen: 58.5586% (minimum 65%, Missing); stomach: 63.1068% (minimum 70%, Missing); thyroid gland: 56.0345% (minimum 65%, Missing); tongue: 57.0175% (minimum 70%, Missing); urinary bladder: 59.6330% (minimum 70%, Missing)",-0.0896552,-0.251724,-0.298611,0,80,unavailable,7.9,8,5.1,"salivary gland: 8 nTPM (protected, limit 3); small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); liver: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); thyroid gland: 5.1 nTPM (manageable, limit 5); tongue: 4.9 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 3); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); lymph node: 3.8 nTPM (protected, limit 3); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150455,TIRAP,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.6330% (minimum 65%, Missing); adrenal gland: 60.1852% (minimum 75%, Missing); cerebellum: 71.4286% (minimum 75%, Missing); cerebral cortex: 69.8925% (minimum 75%, Missing); choroid plexus: 63.7255% (minimum 75%, Missing); colon: 54.1667% (minimum 70%, Missing); duodenum: 45.7746% (minimum 75%, Missing); esophagus: 57.5221% (minimum 70%, Missing); heart muscle: 51.1811% (minimum 75%, Missing); hypothalamus: 73.0337% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 49.6183% (minimum 75%, Missing); lung: 63.1068% (minimum 75%, Missing); lymph node: 63.1068% (minimum 70%, Missing); midbrain: 73.0337% (minimum 75%, Missing); pancreas: 51.5873% (minimum 75%, Missing); parathyroid gland: 49.6183% (minimum 70%, Missing); pituitary gland: 65.0000% (minimum 75%, Missing); rectum: 54.1667% (minimum 70%, Missing); retina: 68.4211% (minimum 75%, Missing); salivary gland: 44.8276% (minimum 70%, Missing); skeletal muscle: 58.0357% (minimum 75%, Missing); skin: 61.9048% (minimum 65%, Missing); small intestine: 45.1389% (minimum 75%, Missing); smooth muscle: 58.0357% (minimum 75%, Missing); spleen: 58.5586% (minimum 65%, Missing); stomach: 63.1068% (minimum 70%, Missing); thyroid gland: 56.0345% (minimum 65%, Missing); tongue: 57.0175% (minimum 70%, Missing); urinary bladder: 59.6330% (minimum 70%, Missing)",-0.0896552,-0.251724,-0.298611,0,80,unavailable,7.9,8,5.1,"salivary gland: 8 nTPM (protected, limit 3); small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); liver: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); thyroid gland: 5.1 nTPM (manageable, limit 5); tongue: 4.9 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 3); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); lymph node: 3.8 nTPM (protected, limit 3); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150455,TIRAP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.6330% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.1852% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 71.4286% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 69.8925% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 63.7255% (minimum 75%, Baseline (adaptation disabled)); colon: 54.1667% (minimum 70%, Baseline (adaptation disabled)); duodenum: 45.7746% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.5221% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 51.1811% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.0337% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.9048% (minimum 75%, Baseline (adaptation disabled)); liver: 49.6183% (minimum 75%, Baseline (adaptation disabled)); lung: 63.1068% (minimum 75%, Baseline (adaptation disabled)); lymph node: 63.1068% (minimum 70%, Baseline (adaptation disabled)); midbrain: 73.0337% (minimum 75%, Baseline (adaptation disabled)); pancreas: 51.5873% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.6183% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 65.0000% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.1667% (minimum 70%, Baseline (adaptation disabled)); retina: 68.4211% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 44.8276% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 58.0357% (minimum 75%, Baseline (adaptation disabled)); skin: 61.9048% (minimum 65%, Baseline (adaptation disabled)); small intestine: 45.1389% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.0357% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.5586% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.1068% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 56.0345% (minimum 65%, Baseline (adaptation disabled)); tongue: 57.0175% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 59.6330% (minimum 70%, Baseline (adaptation disabled))",-0.0896552,-0.251724,-0.298611,0,80,unavailable,7.9,8,5.1,"salivary gland: 8 nTPM (protected, limit 3); small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); liver: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); thyroid gland: 5.1 nTPM (manageable, limit 5); tongue: 4.9 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 3); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); lymph node: 3.8 nTPM (protected, limit 3); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150455,TIRAP,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.0059% (minimum 90%, Approved); adrenal gland: 72.2892% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 81.6327% (minimum 99%, Missing); bone marrow: 45.6274% (minimum 99%, Missing); cerebellum: 83.9161% (minimum 99%, Missing); cerebral cortex: 65.2174% (minimum 99%, Missing); choroid plexus: 67.4157% (minimum 99%, Missing); colon: 75.9494% (minimum 97%, Missing); duodenum: 71.4286% (minimum 99%, Missing); esophagus: 75.4717% (minimum 97%, Missing); heart muscle: 71.4286% (minimum 99%, Missing); hippocampal formation: 80.5369% (minimum 99%, Missing); hypothalamus: 82.1918% (minimum 99%, Missing); kidney: 70.5882% (minimum 99%, Missing); liver: 73.1707% (minimum 99%, Missing); lung: 69.3642% (minimum 99%, Missing); lymph node: 69.3642% (minimum 97%, Missing); midbrain: 76.9231% (minimum 99%, Missing); pancreas: 75.9494% (minimum 99%, Missing); parathyroid gland: 76.4331% (minimum 97%, Missing); pituitary gland: 81.6327% (minimum 99%, Missing); rectum: 78.4314% (minimum 97%, Missing); retina: 36.9231% (minimum 99%, Missing); salivary gland: 64.1711% (minimum 97%, Missing); skeletal muscle: 63.1579% (minimum 99%, Missing); skin: 58.8235% (minimum 95%, Missing); small intestine: 68.5714% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spinal cord: 73.6196% (minimum 99%, Missing); spleen: 68.9655% (minimum 95%, Missing); stomach: 69.3642% (minimum 97%, Missing); thymus: 78.9474% (minimum 95%, Missing); thyroid gland: 71.4286% (minimum 95%, Missing); tongue: 77.4194% (minimum 97%, Missing); urinary bladder: 79.4702% (minimum 97%, Missing)",-0.361765,-0.328289,-0.620769,0,3,partial,20.5,6.7,8.4,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skin: 8.4 nTPM (manageable, limit 5); skeletal muscle: 7 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); pancreas: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.7 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150477,KIAA1328,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.2892% (minimum 75%, Missing); bone marrow: 45.6274% (minimum 75%, Missing); cerebral cortex: 65.2174% (minimum 75%, Missing); choroid plexus: 67.4157% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); kidney: 70.5882% (minimum 75%, Missing); liver: 73.1707% (minimum 75%, Missing); lung: 69.3642% (minimum 75%, Missing); lymph node: 69.3642% (minimum 70%, Missing); retina: 36.9231% (minimum 75%, Missing); salivary gland: 64.1711% (minimum 70%, Missing); skeletal muscle: 63.1579% (minimum 75%, Missing); skin: 58.8235% (minimum 65%, Missing); small intestine: 68.5714% (minimum 75%, Missing); spinal cord: 73.6196% (minimum 75%, Missing); stomach: 69.3642% (minimum 70%, Missing)",-0.0617647,-0.0582888,-0.380769,0,3,partial,20.5,6.7,8.4,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skin: 8.4 nTPM (manageable, limit 5); skeletal muscle: 7 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); pancreas: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.7 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150477,KIAA1328,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.2892% (minimum 75%, Missing); bone marrow: 45.6274% (minimum 75%, Missing); cerebral cortex: 65.2174% (minimum 75%, Missing); choroid plexus: 67.4157% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); kidney: 70.5882% (minimum 75%, Missing); liver: 73.1707% (minimum 75%, Missing); lung: 69.3642% (minimum 75%, Missing); lymph node: 69.3642% (minimum 70%, Missing); retina: 36.9231% (minimum 75%, Missing); salivary gland: 64.1711% (minimum 70%, Missing); skeletal muscle: 63.1579% (minimum 75%, Missing); skin: 58.8235% (minimum 65%, Missing); small intestine: 68.5714% (minimum 75%, Missing); spinal cord: 73.6196% (minimum 75%, Missing); stomach: 69.3642% (minimum 70%, Missing)",-0.0617647,-0.0582888,-0.380769,0,3,partial,20.5,6.7,8.4,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skin: 8.4 nTPM (manageable, limit 5); skeletal muscle: 7 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); pancreas: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.7 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); rectum: 3.3 nTPM (protected, limit 3); urinary bladder: 3.1 nTPM (protected, limit 3); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150477,KIAA1328,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.2892% (minimum 75%, Missing); bone marrow: 45.6274% (minimum 75%, Missing); cerebral cortex: 65.2174% (minimum 75%, Missing); choroid plexus: 67.4157% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); kidney: 70.5882% (minimum 75%, Missing); liver: 73.1707% (minimum 75%, Missing); lung: 69.3642% (minimum 75%, Missing); lymph node: 69.3642% (minimum 70%, Missing); retina: 36.9231% (minimum 75%, Missing); salivary gland: 64.1711% (minimum 70%, Missing); skeletal muscle: 63.1579% (minimum 75%, Missing); skin: 58.8235% (minimum 65%, Missing); small intestine: 68.5714% (minimum 75%, Missing); spinal cord: 73.6196% (minimum 75%, Missing); stomach: 69.3642% (minimum 70%, Missing)",-0.0617647,-0.0582888,-0.380769,0,3,partial,20.5,6.7,8.4,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skin: 8.4 nTPM (manageable, limit 5); skeletal muscle: 7 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); pancreas: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.7 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); rectum: 3.3 nTPM (protected, limit 3); urinary bladder: 3.1 nTPM (protected, limit 3); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150477,KIAA1328,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.2892% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 45.6274% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.2174% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.4157% (minimum 75%, Baseline (adaptation disabled)); duodenum: 71.4286% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.5882% (minimum 75%, Baseline (adaptation disabled)); liver: 73.1707% (minimum 75%, Baseline (adaptation disabled)); lung: 69.3642% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.3642% (minimum 70%, Baseline (adaptation disabled)); retina: 36.9231% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.1711% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 63.1579% (minimum 75%, Baseline (adaptation disabled)); skin: 58.8235% (minimum 65%, Baseline (adaptation disabled)); small intestine: 68.5714% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.6196% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.3642% (minimum 70%, Baseline (adaptation disabled))",-0.0617647,-0.0582888,-0.380769,0,3,partial,20.5,6.7,8.4,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skin: 8.4 nTPM (manageable, limit 5); skeletal muscle: 7 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); pancreas: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.7 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); rectum: 3.3 nTPM (protected, limit 3); urinary bladder: 3.1 nTPM (protected, limit 3); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150477,KIAA1328,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.6467% (minimum 90%, Approved); adrenal gland: 60.0000% (minimum 99%, Missing); amygdala: 87.8719% (minimum 99%, Missing); basal ganglia: 85.5234% (minimum 99%, Missing); bone marrow: 62.3377% (minimum 99%, Missing); cerebellum: 86.2921% (minimum 99%, Missing); cerebral cortex: 80.8421% (minimum 99%, Missing); choroid plexus: 31.3725% (minimum 99%, Missing); colon: 56.4706% (minimum 97%, Missing); duodenum: 33.3333% (minimum 99%, Missing); esophagus: 59.4427% (minimum 97%, Missing); heart muscle: 70.7182% (minimum 98%, Approved); hippocampal formation: 86.4865% (minimum 99%, Missing); hypothalamus: 84.5815% (minimum 99%, Missing); kidney: 34.2246% (minimum 99%, Missing); liver: 22.6682% (minimum 99%, Missing); lung: 72.1805% (minimum 99%, Missing); lymph node: 70.8487% (minimum 97%, Missing); midbrain: 86.6817% (minimum 99%, Missing); pancreas: 47.9401% (minimum 99%, Missing); parathyroid gland: 50.8609% (minimum 97%, Missing); pituitary gland: 71.7757% (minimum 99%, Missing); rectum: 53.4819% (minimum 97%, Missing); retina: 75.5906% (minimum 99%, Missing); salivary gland: 42.9530% (minimum 97%, Missing); skeletal muscle: 42.1978% (minimum 98%, Approved); skin: 80.0000% (minimum 95%, Missing); small intestine: 33.9523% (minimum 99%, Missing); smooth muscle: 76.3419% (minimum 99%, Missing); spinal cord: 84.2105% (minimum 99%, Missing); spleen: 73.1429% (minimum 95%, Missing); stomach: 46.8293% (minimum 97%, Missing); thymus: 73.4226% (minimum 95%, Missing); thyroid gland: 45.9330% (minimum 95%, Missing); tongue: 65.8662% (minimum 97%, Missing); urinary bladder: 71.1111% (minimum 97%, Missing)",-0.49067,-0.54047,-0.763318,0,4,partial,131,51,45.2,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 2); salivary gland: 51 nTPM (protected, limit 2); thyroid gland: 45.2 nTPM (manageable, limit 5); stomach: 43.6 nTPM (protected, limit 2); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 2); rectum: 33.4 nTPM (protected, limit 2); colon: 29.6 nTPM (protected, limit 2); esophagus: 26.2 nTPM (protected, limit 2); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 2); heart muscle: 15.9 nTPM (vital, limit 2); lymph node: 15.8 nTPM (protected, limit 2); urinary bladder: 15.6 nTPM (protected, limit 2); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); spleen: 14.1 nTPM (manageable, limit 5); thymus: 13.9 nTPM (manageable, limit 5); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (manageable, limit 10); skin: 9.6 nTPM (manageable, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150527,MIA2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.0000% (minimum 75%, Missing); bone marrow: 62.3377% (minimum 75%, Missing); choroid plexus: 31.3725% (minimum 75%, Missing); colon: 56.4706% (minimum 70%, Missing); duodenum: 33.3333% (minimum 75%, Missing); esophagus: 59.4427% (minimum 70%, Missing); kidney: 34.2246% (minimum 75%, Missing); liver: 22.6682% (minimum 75%, Missing); lung: 72.1805% (minimum 75%, Missing); pancreas: 47.9401% (minimum 75%, Missing); parathyroid gland: 50.8609% (minimum 70%, Missing); pituitary gland: 71.7757% (minimum 75%, Missing); rectum: 53.4819% (minimum 70%, Missing); salivary gland: 42.9530% (minimum 70%, Missing); skeletal muscle: 42.1978% (minimum 70%, Approved); small intestine: 33.9523% (minimum 75%, Missing); stomach: 46.8293% (minimum 70%, Missing); thyroid gland: 45.9330% (minimum 65%, Missing); tongue: 65.8662% (minimum 70%, Missing)",-0.19067,-0.27047,-0.523318,0,4,partial,131,51,45.2,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 2); salivary gland: 51 nTPM (protected, limit 2); thyroid gland: 45.2 nTPM (manageable, limit 5); stomach: 43.6 nTPM (protected, limit 2); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 2); rectum: 33.4 nTPM (protected, limit 2); colon: 29.6 nTPM (protected, limit 2); esophagus: 26.2 nTPM (protected, limit 2); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 2); heart muscle: 15.9 nTPM (vital, limit 2); lymph node: 15.8 nTPM (protected, limit 2); urinary bladder: 15.6 nTPM (protected, limit 2); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); spleen: 14.1 nTPM (manageable, limit 5); thymus: 13.9 nTPM (manageable, limit 5); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (manageable, limit 10); skin: 9.6 nTPM (manageable, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150527,MIA2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.0000% (minimum 75%, Missing); bone marrow: 62.3377% (minimum 75%, Missing); choroid plexus: 31.3725% (minimum 75%, Missing); colon: 56.4706% (minimum 70%, Missing); duodenum: 33.3333% (minimum 75%, Missing); esophagus: 59.4427% (minimum 70%, Missing); kidney: 34.2246% (minimum 75%, Missing); liver: 22.6682% (minimum 75%, Missing); lung: 72.1805% (minimum 75%, Missing); pancreas: 47.9401% (minimum 75%, Missing); parathyroid gland: 50.8609% (minimum 70%, Missing); pituitary gland: 71.7757% (minimum 75%, Missing); rectum: 53.4819% (minimum 70%, Missing); salivary gland: 42.9530% (minimum 70%, Missing); skeletal muscle: 42.1978% (minimum 70%, Approved); small intestine: 33.9523% (minimum 75%, Missing); stomach: 46.8293% (minimum 70%, Missing); thyroid gland: 45.9330% (minimum 65%, Missing); tongue: 65.8662% (minimum 70%, Missing)",-0.19067,-0.27047,-0.523318,0,4,partial,131,51,45.2,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 2); salivary gland: 51 nTPM (protected, limit 3); thyroid gland: 45.2 nTPM (manageable, limit 5); stomach: 43.6 nTPM (protected, limit 3); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 3); rectum: 33.4 nTPM (protected, limit 3); colon: 29.6 nTPM (protected, limit 3); esophagus: 26.2 nTPM (protected, limit 3); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 3); heart muscle: 15.9 nTPM (vital, limit 2); lymph node: 15.8 nTPM (protected, limit 3); urinary bladder: 15.6 nTPM (protected, limit 3); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); spleen: 14.1 nTPM (manageable, limit 5); thymus: 13.9 nTPM (manageable, limit 5); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (manageable, limit 10); skin: 9.6 nTPM (manageable, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150527,MIA2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.0000% (minimum 75%, Missing); bone marrow: 62.3377% (minimum 75%, Missing); choroid plexus: 31.3725% (minimum 75%, Missing); colon: 56.4706% (minimum 70%, Missing); duodenum: 33.3333% (minimum 75%, Missing); esophagus: 59.4427% (minimum 70%, Missing); kidney: 34.2246% (minimum 75%, Missing); liver: 22.6682% (minimum 75%, Missing); lung: 72.1805% (minimum 75%, Missing); pancreas: 47.9401% (minimum 75%, Missing); parathyroid gland: 50.8609% (minimum 70%, Missing); pituitary gland: 71.7757% (minimum 75%, Missing); rectum: 53.4819% (minimum 70%, Missing); salivary gland: 42.9530% (minimum 70%, Missing); skeletal muscle: 42.1978% (minimum 70%, Approved); small intestine: 33.9523% (minimum 75%, Missing); stomach: 46.8293% (minimum 70%, Missing); thyroid gland: 45.9330% (minimum 65%, Missing); tongue: 65.8662% (minimum 70%, Missing)",-0.19067,-0.27047,-0.523318,0,4,partial,131,51,45.2,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 2); salivary gland: 51 nTPM (protected, limit 3); thyroid gland: 45.2 nTPM (manageable, limit 5); stomach: 43.6 nTPM (protected, limit 3); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 3); rectum: 33.4 nTPM (protected, limit 3); colon: 29.6 nTPM (protected, limit 3); esophagus: 26.2 nTPM (protected, limit 3); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 3); heart muscle: 15.9 nTPM (vital, limit 2); lymph node: 15.8 nTPM (protected, limit 3); urinary bladder: 15.6 nTPM (protected, limit 3); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); spleen: 14.1 nTPM (manageable, limit 5); thymus: 13.9 nTPM (manageable, limit 5); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (manageable, limit 10); skin: 9.6 nTPM (manageable, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150527,MIA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 62.3377% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 31.3725% (minimum 75%, Baseline (adaptation disabled)); colon: 56.4706% (minimum 70%, Baseline (adaptation disabled)); duodenum: 33.3333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.4427% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.7182% (minimum 75%, Baseline (adaptation disabled)); kidney: 34.2246% (minimum 75%, Baseline (adaptation disabled)); liver: 22.6682% (minimum 75%, Baseline (adaptation disabled)); lung: 72.1805% (minimum 75%, Baseline (adaptation disabled)); pancreas: 47.9401% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.8609% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.7757% (minimum 75%, Baseline (adaptation disabled)); rectum: 53.4819% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 42.9530% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 42.1978% (minimum 75%, Baseline (adaptation disabled)); small intestine: 33.9523% (minimum 75%, Baseline (adaptation disabled)); stomach: 46.8293% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 45.9330% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.8662% (minimum 70%, Baseline (adaptation disabled))",-0.19067,-0.27047,-0.523318,0,4,partial,131,51,45.2,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 1); salivary gland: 51 nTPM (protected, limit 3); thyroid gland: 45.2 nTPM (manageable, limit 5); stomach: 43.6 nTPM (protected, limit 3); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 3); rectum: 33.4 nTPM (protected, limit 3); colon: 29.6 nTPM (protected, limit 3); esophagus: 26.2 nTPM (protected, limit 3); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 3); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 3); urinary bladder: 15.6 nTPM (protected, limit 3); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); spleen: 14.1 nTPM (manageable, limit 5); thymus: 13.9 nTPM (manageable, limit 5); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150527,MIA2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.6162% (minimum 99%, Missing); retina: 98.4012% (minimum 99%, Missing)",0.05,0.0270545,-0.00598837,0,3,partial,2.2,0.4,1.6,"retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150628,SPATA4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.297054,0.234012,0,3,partial,2.2,0.4,1.6,"retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150628,SPATA4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.297054,0.234012,0,3,partial,2.2,0.4,1.6,"retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150628,SPATA4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.297054,0.234012,0,3,partial,2.2,0.4,1.6,"retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150628,SPATA4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338321,0.297054,0.234012,0,3,partial,2.2,0.4,1.6,"kidney: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150628,SPATA4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.2222% (minimum 99%, Missing); amygdala: 93.3333% (minimum 99%, Missing); basal ganglia: 90.9091% (minimum 99%, Missing); bone marrow: 92.1053% (minimum 99%, Missing); cerebellum: 97.2222% (minimum 99%, Missing); cerebral cortex: 92.1053% (minimum 99%, Missing); choroid plexus: 77.7778% (minimum 99%, Missing); colon: 49.6454% (minimum 97%, Missing); duodenum: 98.5915% (minimum 99%, Missing); heart muscle: 97.2222% (minimum 99%, Missing); hippocampal formation: 94.5946% (minimum 99%, Missing); hypothalamus: 88.6076% (minimum 99%, Missing); kidney: 89.7436% (minimum 99%, Missing); liver: 98.5915% (minimum 99%, Missing); lung: 97.2222% (minimum 99%, Missing); midbrain: 95.8904% (minimum 99%, Missing); pancreas: 98.5915% (minimum 99%, Missing); parathyroid gland: 89.7436% (minimum 97%, Missing); pituitary gland: 83.3333% (minimum 99%, Missing); rectum: 39.7727% (minimum 97%, Missing); retina: 89.7436% (minimum 99%, Missing); skeletal muscle: 97.2222% (minimum 99%, Missing); skin: 89.7436% (minimum 95%, Missing); small intestine: 98.5915% (minimum 99%, Missing); smooth muscle: 95.8904% (minimum 99%, Missing); spinal cord: 97.2222% (minimum 99%, Missing); stomach: 93.3333% (minimum 97%, Missing); thymus: 84.3373% (minimum 95%, Missing); thyroid gland: 94.5946% (minimum 95%, Missing); urinary bladder: 95.8904% (minimum 97%, Missing)",-0.106627,-0.572273,-0.212222,0,80,unavailable,2,10.6,1.3,"rectum: 10.6 nTPM (protected, limit 2); colon: 7.1 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150667,FSIP1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 49.6454% (minimum 70%, Missing); rectum: 39.7727% (minimum 70%, Missing)",0.193373,-0.302273,0.0277778,0,80,unavailable,2,10.6,1.3,"rectum: 10.6 nTPM (protected, limit 2); colon: 7.1 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150667,FSIP1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 49.6454% (minimum 70%, Missing); rectum: 39.7727% (minimum 70%, Missing)",0.193373,-0.302273,0.0277778,0,80,unavailable,2,10.6,1.3,"rectum: 10.6 nTPM (protected, limit 3); colon: 7.1 nTPM (protected, limit 3); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150667,FSIP1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 49.6454% (minimum 70%, Missing); rectum: 39.7727% (minimum 70%, Missing)",0.193373,-0.302273,0.0277778,0,80,unavailable,2,10.6,1.3,"rectum: 10.6 nTPM (protected, limit 3); colon: 7.1 nTPM (protected, limit 3); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150667,FSIP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 49.6454% (minimum 70%, Baseline (adaptation disabled)); rectum: 39.7727% (minimum 70%, Baseline (adaptation disabled))",0.193373,-0.302273,0.0277778,0,80,unavailable,2,10.6,1.3,"rectum: 10.6 nTPM (protected, limit 3); colon: 7.1 nTPM (protected, limit 3); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150667,FSIP1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150676,CCDC83,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150676,CCDC83,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150676,CCDC83,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150676,CCDC83,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150676,CCDC83,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9361% (minimum 95%, Missing); adrenal gland: 75.6173% (minimum 98%, Approved); amygdala: 42.6829% (minimum 99%, Missing); basal ganglia: 44.1441% (minimum 99%, Missing); bone marrow: 97.2222% (minimum 99%, Missing); cerebellum: 80.8581% (minimum 99%, Missing); cerebral cortex: 55.8087% (minimum 99%, Missing); choroid plexus: 70.6052% (minimum 99%, Missing); colon: 58.8942% (minimum 97%, Missing); duodenum: 65.3333% (minimum 99%, Missing); esophagus: 60.9453% (minimum 97%, Missing); heart muscle: 64.1361% (minimum 99%, Missing); hippocampal formation: 46.0526% (minimum 99%, Missing); hypothalamus: 53.0303% (minimum 99%, Missing); kidney: 56.8445% (minimum 99%, Missing); liver: 72.4852% (minimum 99%, Missing); lung: 64.8148% (minimum 99%, Missing); lymph node: 84.4828% (minimum 95%, Approved); midbrain: 40.8333% (minimum 99%, Missing); pancreas: 64.1361% (minimum 99%, Missing); parathyroid gland: 49.7967% (minimum 97%, Missing); pituitary gland: 81.6667% (minimum 99%, Missing); rectum: 64.6438% (minimum 95%, Approved); retina: 91.7603% (minimum 99%, Missing); salivary gland: 58.7530% (minimum 97%, Missing); skeletal muscle: 83.0508% (minimum 98%, Approved); skin: 42.9825% (minimum 95%, Missing); small intestine: 62.6598% (minimum 99%, Missing); smooth muscle: 56.9767% (minimum 99%, Missing); spinal cord: 45.2030% (minimum 99%, Missing); spleen: 71.6374% (minimum 95%, Missing); stomach: 65.5080% (minimum 97%, Missing); thymus: 74.6951% (minimum 95%, Missing); thyroid gland: 48.7078% (minimum 95%, Missing); tongue: 70.8092% (minimum 97%, Missing); urinary bladder: 60.6436% (minimum 97%, Missing)",-0.520175,-0.472033,-0.581667,0,7,partial,35.5,24.7,32.5,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); skin: 32.5 nTPM (manageable, limit 5); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (manageable, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 2); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 2); colon: 17.1 nTPM (protected, limit 2); urinary bladder: 15.9 nTPM (protected, limit 2); esophagus: 15.7 nTPM (protected, limit 2); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 4); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 2); spleen: 9.7 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.9 nTPM (vital, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 2); lymph node: 4.5 nTPM (protected, limit 4); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150760,DOCK1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9361% (minimum 65%, Missing); amygdala: 42.6829% (minimum 75%, Missing); basal ganglia: 44.1441% (minimum 75%, Missing); cerebral cortex: 55.8087% (minimum 75%, Missing); choroid plexus: 70.6052% (minimum 75%, Missing); colon: 58.8942% (minimum 70%, Missing); duodenum: 65.3333% (minimum 75%, Missing); esophagus: 60.9453% (minimum 70%, Missing); heart muscle: 64.1361% (minimum 75%, Missing); hippocampal formation: 46.0526% (minimum 75%, Missing); hypothalamus: 53.0303% (minimum 75%, Missing); kidney: 56.8445% (minimum 75%, Missing); liver: 72.4852% (minimum 75%, Missing); lung: 64.8148% (minimum 75%, Missing); midbrain: 40.8333% (minimum 75%, Missing); pancreas: 64.1361% (minimum 75%, Missing); parathyroid gland: 49.7967% (minimum 70%, Missing); rectum: 64.6438% (minimum 65%, Approved); salivary gland: 58.7530% (minimum 70%, Missing); skin: 42.9825% (minimum 65%, Missing); small intestine: 62.6598% (minimum 75%, Missing); smooth muscle: 56.9767% (minimum 75%, Missing); spinal cord: 45.2030% (minimum 75%, Missing); stomach: 65.5080% (minimum 70%, Missing); thyroid gland: 48.7078% (minimum 65%, Missing); urinary bladder: 60.6436% (minimum 70%, Missing)",-0.220175,-0.202033,-0.341667,0,7,partial,35.5,24.7,32.5,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); skin: 32.5 nTPM (manageable, limit 5); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (manageable, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 2); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 2); colon: 17.1 nTPM (protected, limit 2); urinary bladder: 15.9 nTPM (protected, limit 2); esophagus: 15.7 nTPM (protected, limit 2); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 4); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 2); spleen: 9.7 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.9 nTPM (vital, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 2); lymph node: 4.5 nTPM (protected, limit 4); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150760,DOCK1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9361% (minimum 65%, Missing); amygdala: 42.6829% (minimum 75%, Missing); basal ganglia: 44.1441% (minimum 75%, Missing); cerebral cortex: 55.8087% (minimum 75%, Missing); choroid plexus: 70.6052% (minimum 75%, Missing); colon: 58.8942% (minimum 70%, Missing); duodenum: 65.3333% (minimum 75%, Missing); esophagus: 60.9453% (minimum 70%, Missing); heart muscle: 64.1361% (minimum 75%, Missing); hippocampal formation: 46.0526% (minimum 75%, Missing); hypothalamus: 53.0303% (minimum 75%, Missing); kidney: 56.8445% (minimum 75%, Missing); liver: 72.4852% (minimum 75%, Missing); lung: 64.8148% (minimum 75%, Missing); midbrain: 40.8333% (minimum 75%, Missing); pancreas: 64.1361% (minimum 75%, Missing); parathyroid gland: 49.7967% (minimum 70%, Missing); rectum: 64.6438% (minimum 65%, Approved); salivary gland: 58.7530% (minimum 70%, Missing); skin: 42.9825% (minimum 65%, Missing); small intestine: 62.6598% (minimum 75%, Missing); smooth muscle: 56.9767% (minimum 75%, Missing); spinal cord: 45.2030% (minimum 75%, Missing); stomach: 65.5080% (minimum 70%, Missing); thyroid gland: 48.7078% (minimum 65%, Missing); urinary bladder: 60.6436% (minimum 70%, Missing)",-0.220175,-0.202033,-0.341667,0,7,partial,35.5,24.7,32.5,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); skin: 32.5 nTPM (manageable, limit 5); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (manageable, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 3); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 3); colon: 17.1 nTPM (protected, limit 3); urinary bladder: 15.9 nTPM (protected, limit 3); esophagus: 15.7 nTPM (protected, limit 3); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 4); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 3); spleen: 9.7 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.9 nTPM (vital, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 2); lymph node: 4.5 nTPM (protected, limit 4); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150760,DOCK1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9361% (minimum 65%, Missing); amygdala: 42.6829% (minimum 75%, Missing); basal ganglia: 44.1441% (minimum 75%, Missing); cerebral cortex: 55.8087% (minimum 75%, Missing); choroid plexus: 70.6052% (minimum 75%, Missing); colon: 58.8942% (minimum 70%, Missing); duodenum: 65.3333% (minimum 75%, Missing); esophagus: 60.9453% (minimum 70%, Missing); heart muscle: 64.1361% (minimum 75%, Missing); hippocampal formation: 46.0526% (minimum 75%, Missing); hypothalamus: 53.0303% (minimum 75%, Missing); kidney: 56.8445% (minimum 75%, Missing); liver: 72.4852% (minimum 75%, Missing); lung: 64.8148% (minimum 75%, Missing); midbrain: 40.8333% (minimum 75%, Missing); pancreas: 64.1361% (minimum 75%, Missing); parathyroid gland: 49.7967% (minimum 70%, Missing); rectum: 64.6438% (minimum 65%, Approved); salivary gland: 58.7530% (minimum 70%, Missing); skin: 42.9825% (minimum 65%, Missing); small intestine: 62.6598% (minimum 75%, Missing); smooth muscle: 56.9767% (minimum 75%, Missing); spinal cord: 45.2030% (minimum 75%, Missing); stomach: 65.5080% (minimum 70%, Missing); thyroid gland: 48.7078% (minimum 65%, Missing); urinary bladder: 60.6436% (minimum 70%, Missing)",-0.220175,-0.202033,-0.341667,0,7,partial,35.5,24.7,32.5,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); skin: 32.5 nTPM (manageable, limit 5); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (manageable, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 3); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 3); colon: 17.1 nTPM (protected, limit 3); urinary bladder: 15.9 nTPM (protected, limit 3); esophagus: 15.7 nTPM (protected, limit 3); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 4); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 3); spleen: 9.7 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.9 nTPM (vital, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 2); lymph node: 4.5 nTPM (protected, limit 4); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150760,DOCK1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9361% (minimum 65%, Baseline (adaptation disabled)); amygdala: 42.6829% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 44.1441% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 55.8087% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.6052% (minimum 75%, Baseline (adaptation disabled)); colon: 58.8942% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.3333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.9453% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.1361% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 46.0526% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.0303% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.8445% (minimum 75%, Baseline (adaptation disabled)); liver: 72.4852% (minimum 75%, Baseline (adaptation disabled)); lung: 64.8148% (minimum 75%, Baseline (adaptation disabled)); midbrain: 40.8333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.1361% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.7967% (minimum 70%, Baseline (adaptation disabled)); rectum: 64.6438% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 58.7530% (minimum 70%, Baseline (adaptation disabled)); skin: 42.9825% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.6598% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.9767% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 45.2030% (minimum 75%, Baseline (adaptation disabled)); stomach: 65.5080% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 48.7078% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 60.6436% (minimum 70%, Baseline (adaptation disabled))",-0.220175,-0.202033,-0.341667,0,7,partial,35.5,24.7,32.5,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); skin: 32.5 nTPM (manageable, limit 5); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (manageable, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 3); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 3); colon: 17.1 nTPM (protected, limit 3); urinary bladder: 15.9 nTPM (protected, limit 3); esophagus: 15.7 nTPM (protected, limit 3); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 3); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 3); spleen: 9.7 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.9 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150760,DOCK1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4733% (minimum 99%, Missing); amygdala: 97.7273% (minimum 99%, Missing); basal ganglia: 96.8468% (minimum 99%, Missing); cerebellum: 98.6239% (minimum 99%, Missing); cerebral cortex: 98.0243% (minimum 99%, Missing); choroid plexus: 87.3984% (minimum 99%, Missing); heart muscle: 98.1735% (minimum 99%, Missing); hippocampal formation: 97.1386% (minimum 99%, Missing); hypothalamus: 96.8468% (minimum 99%, Missing); kidney: 94.5748% (minimum 99%, Missing); liver: 98.9264% (minimum 99%, Missing); lung: 95.8395% (minimum 99%, Missing); midbrain: 98.0243% (minimum 99%, Missing); pancreas: 98.3232% (minimum 99%, Missing); parathyroid gland: 94.1606% (minimum 97%, Missing); pituitary gland: 95.2733% (minimum 99%, Missing); retina: 84.3137% (minimum 99%, Missing); skeletal muscle: 98.4733% (minimum 99%, Missing); spinal cord: 98.7749% (minimum 99%, Missing); thyroid gland: 92.5395% (minimum 95%, Missing)",-0.0246055,-0.0283942,-0.146863,0,80,unavailable,12,4,5.2,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4 nTPM (protected, limit 2); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150773,PIH1D2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.275395,0.241606,0.0931373,0,80,unavailable,12,4,5.2,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4 nTPM (protected, limit 2); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150773,PIH1D2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.275395,0.241606,0.0931373,0,80,unavailable,12,4,5.2,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4 nTPM (protected, limit 3); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150773,PIH1D2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.275395,0.241606,0.0931373,0,80,unavailable,12,4,5.2,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4 nTPM (protected, limit 3); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150773,PIH1D2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.275395,0.241606,0.0931373,0,80,unavailable,12,4,5.2,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4 nTPM (protected, limit 3); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150773,PIH1D2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1045% (minimum 95%, Missing); adrenal gland: 64.2857% (minimum 99%, Missing); amygdala: 60.1824% (minimum 99%, Missing); basal ganglia: 62.4606% (minimum 99%, Missing); bone marrow: 60.7362% (minimum 99%, Missing); cerebellum: 47.4820% (minimum 99%, Missing); cerebral cortex: 58.4071% (minimum 99%, Missing); choroid plexus: 72.2628% (minimum 99%, Missing); colon: 62.6582% (minimum 97%, Missing); duodenum: 64.2857% (minimum 99%, Missing); esophagus: 59.6386% (minimum 95%, Approved); heart muscle: 61.1111% (minimum 98%, Approved); hippocampal formation: 60.5505% (minimum 99%, Missing); hypothalamus: 58.7537% (minimum 99%, Missing); kidney: 58.4071% (minimum 99%, Missing); liver: 63.4615% (minimum 99%, Missing); lung: 64.9180% (minimum 99%, Missing); lymph node: 58.9286% (minimum 97%, Missing); midbrain: 59.4595% (minimum 99%, Missing); pancreas: 62.4606% (minimum 99%, Missing); parathyroid gland: 59.2814% (minimum 95%, Approved); pituitary gland: 72.5275% (minimum 99%, Missing); rectum: 63.6656% (minimum 97%, Missing); retina: 37.9310% (minimum 99%, Missing); salivary gland: 59.8187% (minimum 97%, Missing); skeletal muscle: 52.5199% (minimum 98%, Approved); skin: 62.6582% (minimum 95%, Missing); small intestine: 64.7059% (minimum 99%, Missing); smooth muscle: 62.2642% (minimum 98%, Approved); spinal cord: 59.2814% (minimum 99%, Missing); spleen: 61.6822% (minimum 90%, Approved); stomach: 63.8710% (minimum 97%, Missing); thymus: 54.5455% (minimum 95%, Missing); thyroid gland: 56.0907% (minimum 95%, Missing); tongue: 67.1186% (minimum 97%, Missing); urinary bladder: 64.0777% (minimum 97%, Missing)",-0.404545,-0.380714,-0.61069,0,5,partial,32.4,13.8,16.5,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 2); thymus: 16.5 nTPM (manageable, limit 5); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 2); adipose tissue: 13.7 nTPM (manageable, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 4); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 4); salivary gland: 13.3 nTPM (protected, limit 2); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 2); spleen: 12.3 nTPM (manageable, limit 10); smooth muscle: 12 nTPM (vital, limit 2); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); colon: 11.8 nTPM (protected, limit 2); liver: 11.4 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 2); stomach: 11.2 nTPM (protected, limit 2); urinary bladder: 11.1 nTPM (protected, limit 2); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 2); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150776,NKAPD1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1045% (minimum 65%, Missing); adrenal gland: 64.2857% (minimum 75%, Missing); amygdala: 60.1824% (minimum 75%, Missing); basal ganglia: 62.4606% (minimum 75%, Missing); bone marrow: 60.7362% (minimum 75%, Missing); cerebellum: 47.4820% (minimum 75%, Missing); cerebral cortex: 58.4071% (minimum 75%, Missing); choroid plexus: 72.2628% (minimum 75%, Missing); colon: 62.6582% (minimum 70%, Missing); duodenum: 64.2857% (minimum 75%, Missing); esophagus: 59.6386% (minimum 65%, Approved); heart muscle: 61.1111% (minimum 70%, Approved); hippocampal formation: 60.5505% (minimum 75%, Missing); hypothalamus: 58.7537% (minimum 75%, Missing); kidney: 58.4071% (minimum 75%, Missing); liver: 63.4615% (minimum 75%, Missing); lung: 64.9180% (minimum 75%, Missing); lymph node: 58.9286% (minimum 70%, Missing); midbrain: 59.4595% (minimum 75%, Missing); pancreas: 62.4606% (minimum 75%, Missing); parathyroid gland: 59.2814% (minimum 65%, Approved); pituitary gland: 72.5275% (minimum 75%, Missing); rectum: 63.6656% (minimum 70%, Missing); retina: 37.9310% (minimum 75%, Missing); salivary gland: 59.8187% (minimum 70%, Missing); skeletal muscle: 52.5199% (minimum 70%, Approved); skin: 62.6582% (minimum 65%, Missing); small intestine: 64.7059% (minimum 75%, Missing); smooth muscle: 62.2642% (minimum 70%, Approved); spinal cord: 59.2814% (minimum 75%, Missing); stomach: 63.8710% (minimum 70%, Missing); thymus: 54.5455% (minimum 65%, Missing); thyroid gland: 56.0907% (minimum 65%, Missing); tongue: 67.1186% (minimum 70%, Missing); urinary bladder: 64.0777% (minimum 70%, Missing)",-0.104545,-0.110714,-0.37069,0,5,partial,32.4,13.8,16.5,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 2); thymus: 16.5 nTPM (manageable, limit 5); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 2); adipose tissue: 13.7 nTPM (manageable, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 4); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 4); salivary gland: 13.3 nTPM (protected, limit 2); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 2); spleen: 12.3 nTPM (manageable, limit 10); smooth muscle: 12 nTPM (vital, limit 2); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); colon: 11.8 nTPM (protected, limit 2); liver: 11.4 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 2); stomach: 11.2 nTPM (protected, limit 2); urinary bladder: 11.1 nTPM (protected, limit 2); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 2); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150776,NKAPD1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1045% (minimum 65%, Missing); adrenal gland: 64.2857% (minimum 75%, Missing); amygdala: 60.1824% (minimum 75%, Missing); basal ganglia: 62.4606% (minimum 75%, Missing); bone marrow: 60.7362% (minimum 75%, Missing); cerebellum: 47.4820% (minimum 75%, Missing); cerebral cortex: 58.4071% (minimum 75%, Missing); choroid plexus: 72.2628% (minimum 75%, Missing); colon: 62.6582% (minimum 70%, Missing); duodenum: 64.2857% (minimum 75%, Missing); esophagus: 59.6386% (minimum 65%, Approved); heart muscle: 61.1111% (minimum 70%, Approved); hippocampal formation: 60.5505% (minimum 75%, Missing); hypothalamus: 58.7537% (minimum 75%, Missing); kidney: 58.4071% (minimum 75%, Missing); liver: 63.4615% (minimum 75%, Missing); lung: 64.9180% (minimum 75%, Missing); lymph node: 58.9286% (minimum 70%, Missing); midbrain: 59.4595% (minimum 75%, Missing); pancreas: 62.4606% (minimum 75%, Missing); parathyroid gland: 59.2814% (minimum 65%, Approved); pituitary gland: 72.5275% (minimum 75%, Missing); rectum: 63.6656% (minimum 70%, Missing); retina: 37.9310% (minimum 75%, Missing); salivary gland: 59.8187% (minimum 70%, Missing); skeletal muscle: 52.5199% (minimum 70%, Approved); skin: 62.6582% (minimum 65%, Missing); small intestine: 64.7059% (minimum 75%, Missing); smooth muscle: 62.2642% (minimum 70%, Approved); spinal cord: 59.2814% (minimum 75%, Missing); stomach: 63.8710% (minimum 70%, Missing); thymus: 54.5455% (minimum 65%, Missing); thyroid gland: 56.0907% (minimum 65%, Missing); tongue: 67.1186% (minimum 70%, Missing); urinary bladder: 64.0777% (minimum 70%, Missing)",-0.104545,-0.110714,-0.37069,0,5,partial,32.4,13.8,16.5,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 2); thymus: 16.5 nTPM (manageable, limit 5); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 3); adipose tissue: 13.7 nTPM (manageable, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 4); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 4); salivary gland: 13.3 nTPM (protected, limit 3); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 2); spleen: 12.3 nTPM (manageable, limit 10); smooth muscle: 12 nTPM (vital, limit 2); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); colon: 11.8 nTPM (protected, limit 3); liver: 11.4 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 3); stomach: 11.2 nTPM (protected, limit 3); urinary bladder: 11.1 nTPM (protected, limit 3); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 3); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150776,NKAPD1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1045% (minimum 65%, Missing); adrenal gland: 64.2857% (minimum 75%, Missing); amygdala: 60.1824% (minimum 75%, Missing); basal ganglia: 62.4606% (minimum 75%, Missing); bone marrow: 60.7362% (minimum 75%, Missing); cerebellum: 47.4820% (minimum 75%, Missing); cerebral cortex: 58.4071% (minimum 75%, Missing); choroid plexus: 72.2628% (minimum 75%, Missing); colon: 62.6582% (minimum 70%, Missing); duodenum: 64.2857% (minimum 75%, Missing); esophagus: 59.6386% (minimum 65%, Approved); heart muscle: 61.1111% (minimum 70%, Approved); hippocampal formation: 60.5505% (minimum 75%, Missing); hypothalamus: 58.7537% (minimum 75%, Missing); kidney: 58.4071% (minimum 75%, Missing); liver: 63.4615% (minimum 75%, Missing); lung: 64.9180% (minimum 75%, Missing); lymph node: 58.9286% (minimum 70%, Missing); midbrain: 59.4595% (minimum 75%, Missing); pancreas: 62.4606% (minimum 75%, Missing); parathyroid gland: 59.2814% (minimum 65%, Approved); pituitary gland: 72.5275% (minimum 75%, Missing); rectum: 63.6656% (minimum 70%, Missing); retina: 37.9310% (minimum 75%, Missing); salivary gland: 59.8187% (minimum 70%, Missing); skeletal muscle: 52.5199% (minimum 70%, Approved); skin: 62.6582% (minimum 65%, Missing); small intestine: 64.7059% (minimum 75%, Missing); smooth muscle: 62.2642% (minimum 70%, Approved); spinal cord: 59.2814% (minimum 75%, Missing); stomach: 63.8710% (minimum 70%, Missing); thymus: 54.5455% (minimum 65%, Missing); thyroid gland: 56.0907% (minimum 65%, Missing); tongue: 67.1186% (minimum 70%, Missing); urinary bladder: 64.0777% (minimum 70%, Missing)",-0.104545,-0.110714,-0.37069,0,5,partial,32.4,13.8,16.5,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 2); thymus: 16.5 nTPM (manageable, limit 5); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 3); adipose tissue: 13.7 nTPM (manageable, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 4); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 4); salivary gland: 13.3 nTPM (protected, limit 3); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 2); spleen: 12.3 nTPM (manageable, limit 10); smooth muscle: 12 nTPM (vital, limit 2); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); colon: 11.8 nTPM (protected, limit 3); liver: 11.4 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 3); stomach: 11.2 nTPM (protected, limit 3); urinary bladder: 11.1 nTPM (protected, limit 3); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 3); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150776,NKAPD1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1045% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 64.2857% (minimum 75%, Baseline (adaptation disabled)); amygdala: 60.1824% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.4606% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 60.7362% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 47.4820% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.4071% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.2628% (minimum 75%, Baseline (adaptation disabled)); colon: 62.6582% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.2857% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.6386% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 61.1111% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 60.5505% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.7537% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.4071% (minimum 75%, Baseline (adaptation disabled)); liver: 63.4615% (minimum 75%, Baseline (adaptation disabled)); lung: 64.9180% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.9286% (minimum 70%, Baseline (adaptation disabled)); midbrain: 59.4595% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.4606% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.2814% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.5275% (minimum 75%, Baseline (adaptation disabled)); rectum: 63.6656% (minimum 70%, Baseline (adaptation disabled)); retina: 37.9310% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.8187% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 52.5199% (minimum 75%, Baseline (adaptation disabled)); skin: 62.6582% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.7059% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.2642% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.2814% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.6822% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.8710% (minimum 70%, Baseline (adaptation disabled)); thymus: 54.5455% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.0907% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.1186% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 64.0777% (minimum 70%, Baseline (adaptation disabled))",-0.104545,-0.110714,-0.37069,0,5,partial,32.4,13.8,16.5,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 1); thymus: 16.5 nTPM (manageable, limit 5); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 3); adipose tissue: 13.7 nTPM (manageable, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 3); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 3); salivary gland: 13.3 nTPM (protected, limit 3); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); smooth muscle: 12 nTPM (vital, limit 1); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); colon: 11.8 nTPM (protected, limit 3); liver: 11.4 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 3); stomach: 11.2 nTPM (protected, limit 3); urinary bladder: 11.1 nTPM (protected, limit 3); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 3); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150776,NKAPD1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.5263% (minimum 99%, Missing); tongue: 96.6346% (minimum 97%, Missing)",0.0450495,-0.00365385,-0.284737,0,1,partial,8.4,0.7,0.7,"retina: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150783,TEX12,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.5263% (minimum 75%, Missing)",0.34505,0.266346,-0.0447368,0,1,partial,8.4,0.7,0.7,"retina: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150783,TEX12,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.5263% (minimum 75%, Missing)",0.34505,0.266346,-0.0447368,0,1,partial,8.4,0.7,0.7,"retina: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150783,TEX12,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.5263% (minimum 75%, Missing)",0.34505,0.266346,-0.0447368,0,1,partial,8.4,0.7,0.7,"retina: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150783,TEX12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.5263% (minimum 75%, Baseline (adaptation disabled))",0.316346,0.266346,-0.0447368,0,1,partial,8.4,0.7,0.7,"retina: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000150783,TEX12,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.0482206,0.03,0.00822064,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151005,TKTL2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348221,0.3,0.248221,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151005,TKTL2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348221,0.3,0.248221,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151005,TKTL2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348221,0.3,0.248221,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151005,TKTL2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348221,0.3,0.248221,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151005,TKTL2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151033,LYZL2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151033,LYZL2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151033,LYZL2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151033,LYZL2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151033,LYZL2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 50.0000% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 75.0000% (minimum 97%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); lung: 60.0000% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pituitary gland: 60.0000% (minimum 99%, Missing); retina: 1.5152% (minimum 99%, Missing); salivary gland: 75.0000% (minimum 97%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 60.0000% (minimum 99%, Missing); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); thymus: 75.0000% (minimum 95%, Missing); tongue: 42.8571% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",-0.45,-0.541429,-0.974848,0,80,unavailable,19.5,0.4,0.3,"retina: 19.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151062,CACNA2D4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); adrenal gland: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 50.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); duodenum: 50.0000% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 1.5152% (minimum 75%, Missing); small intestine: 75.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); tongue: 42.8571% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.15,-0.271429,-0.734848,0,80,unavailable,19.5,0.4,0.3,"retina: 19.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151062,CACNA2D4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); adrenal gland: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 50.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); duodenum: 50.0000% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 1.5152% (minimum 75%, Missing); small intestine: 75.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); tongue: 42.8571% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.15,-0.271429,-0.734848,0,80,unavailable,19.5,0.4,0.3,"retina: 19.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151062,CACNA2D4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); adrenal gland: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 50.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); duodenum: 50.0000% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 1.5152% (minimum 75%, Missing); small intestine: 75.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); tongue: 42.8571% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.15,-0.271429,-0.734848,0,80,unavailable,19.5,0.4,0.3,"retina: 19.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151062,CACNA2D4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 75.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 50.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 60.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 70%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 1.5152% (minimum 75%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 42.8571% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 70%, Baseline (adaptation disabled))",-0.15,-0.271429,-0.734848,0,80,unavailable,19.5,0.4,0.3,"retina: 19.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151062,CACNA2D4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.4912% (minimum 99%, Missing); basal ganglia: 96.4912% (minimum 99%, Missing); bone marrow: 97.3451% (minimum 98%, Approved); cerebral cortex: 97.3451% (minimum 98%, Approved); heart muscle: 94.0171% (minimum 98%, Approved); hippocampal formation: 96.4912% (minimum 99%, Missing); hypothalamus: 97.3451% (minimum 99%, Missing); liver: 97.3451% (minimum 98%, Approved); lung: 97.3451% (minimum 98%, Approved); midbrain: 95.6522% (minimum 99%, Missing); retina: 96.4912% (minimum 99%, Missing); skeletal muscle: 93.2203% (minimum 99%, Missing); smooth muscle: 96.4912% (minimum 98%, Approved); spinal cord: 94.0171% (minimum 99%, Missing); tongue: 95.6522% (minimum 97%, Missing)",0.0149123,-0.0134783,-0.0577966,0,1,partial,0.8,0.5,0.4,,skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151164,RAD9B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.314912,0.256522,0.182203,0,1,partial,0.8,0.5,0.4,,skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151164,RAD9B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.314912,0.256522,0.182203,0,1,partial,0.8,0.5,0.4,,skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151164,RAD9B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.314912,0.256522,0.182203,0,1,partial,0.8,0.5,0.4,,skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151164,RAD9B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.314912,0.256522,0.182203,0,1,partial,0.8,0.5,0.4,,skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151164,RAD9B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.3844% (minimum 95%, Missing); adrenal gland: 62.5773% (minimum 99%, Missing); amygdala: 70.3360% (minimum 99%, Missing); basal ganglia: 71.4959% (minimum 99%, Missing); bone marrow: 51.7477% (minimum 99%, Missing); cerebellum: 73.4867% (minimum 99%, Missing); cerebral cortex: 62.5129% (minimum 99%, Missing); choroid plexus: 66.4114% (minimum 99%, Missing); colon: 58.1975% (minimum 97%, Missing); duodenum: 63.4274% (minimum 99%, Missing); esophagus: 54.8329% (minimum 97%, Missing); heart muscle: 62.6419% (minimum 99%, Missing); hippocampal formation: 72.8691% (minimum 99%, Missing); hypothalamus: 66.7033% (minimum 99%, Missing); kidney: 57.0489% (minimum 99%, Missing); liver: 59.1042% (minimum 99%, Missing); lung: 69.8504% (minimum 99%, Missing); lymph node: 58.1975% (minimum 97%, Missing); midbrain: 67.4444% (minimum 99%, Missing); pancreas: 69.7701% (minimum 99%, Missing); parathyroid gland: 58.2534% (minimum 97%, Missing); pituitary gland: 78.5252% (minimum 99%, Missing); rectum: 54.5373% (minimum 97%, Missing); retina: 53.6693% (minimum 99%, Missing); salivary gland: 66.7033% (minimum 97%, Missing); skeletal muscle: 61.6244% (minimum 99%, Missing); skin: 72.1760% (minimum 95%, Missing); small intestine: 64.4374% (minimum 99%, Missing); smooth muscle: 61.5619% (minimum 99%, Missing); spinal cord: 62.9668% (minimum 99%, Missing); spleen: 66.4841% (minimum 95%, Missing); stomach: 63.4937% (minimum 97%, Missing); thymus: 53.9556% (minimum 95%, Missing); thyroid gland: 54.3420% (minimum 95%, Missing); tongue: 56.7290% (minimum 97%, Missing); urinary bladder: 53.6693% (minimum 97%, Missing)",-0.410444,-0.433307,-0.472523,0,9,partial,56.6,52.4,51.8,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 2); retina: 52.4 nTPM (vital, limit 1); thymus: 51.8 nTPM (manageable, limit 5); thyroid gland: 51 nTPM (manageable, limit 5); rectum: 50.6 nTPM (protected, limit 2); esophagus: 50 nTPM (protected, limit 2); tongue: 46.3 nTPM (protected, limit 2); kidney: 45.7 nTPM (vital, limit 1); colon: 43.6 nTPM (protected, limit 2); lymph node: 43.6 nTPM (protected, limit 2); parathyroid gland: 43.5 nTPM (protected, limit 2); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); adipose tissue: 36.6 nTPM (manageable, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 2); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); spleen: 30.6 nTPM (manageable, limit 5); salivary gland: 30.3 nTPM (protected, limit 2); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); skin: 23.4 nTPM (manageable, limit 5); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: High (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / eccrine glands: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: High (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: High (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151247,EIF4E,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.3844% (minimum 65%, Missing); adrenal gland: 62.5773% (minimum 75%, Missing); amygdala: 70.3360% (minimum 75%, Missing); basal ganglia: 71.4959% (minimum 75%, Missing); bone marrow: 51.7477% (minimum 75%, Missing); cerebellum: 73.4867% (minimum 75%, Missing); cerebral cortex: 62.5129% (minimum 75%, Missing); choroid plexus: 66.4114% (minimum 75%, Missing); colon: 58.1975% (minimum 70%, Missing); duodenum: 63.4274% (minimum 75%, Missing); esophagus: 54.8329% (minimum 70%, Missing); heart muscle: 62.6419% (minimum 75%, Missing); hippocampal formation: 72.8691% (minimum 75%, Missing); hypothalamus: 66.7033% (minimum 75%, Missing); kidney: 57.0489% (minimum 75%, Missing); liver: 59.1042% (minimum 75%, Missing); lung: 69.8504% (minimum 75%, Missing); lymph node: 58.1975% (minimum 70%, Missing); midbrain: 67.4444% (minimum 75%, Missing); pancreas: 69.7701% (minimum 75%, Missing); parathyroid gland: 58.2534% (minimum 70%, Missing); rectum: 54.5373% (minimum 70%, Missing); retina: 53.6693% (minimum 75%, Missing); salivary gland: 66.7033% (minimum 70%, Missing); skeletal muscle: 61.6244% (minimum 75%, Missing); small intestine: 64.4374% (minimum 75%, Missing); smooth muscle: 61.5619% (minimum 75%, Missing); spinal cord: 62.9668% (minimum 75%, Missing); stomach: 63.4937% (minimum 70%, Missing); thymus: 53.9556% (minimum 65%, Missing); thyroid gland: 54.3420% (minimum 65%, Missing); tongue: 56.7290% (minimum 70%, Missing); urinary bladder: 53.6693% (minimum 70%, Missing)",-0.110444,-0.163307,-0.232523,0,9,partial,56.6,52.4,51.8,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 2); retina: 52.4 nTPM (vital, limit 1); thymus: 51.8 nTPM (manageable, limit 5); thyroid gland: 51 nTPM (manageable, limit 5); rectum: 50.6 nTPM (protected, limit 2); esophagus: 50 nTPM (protected, limit 2); tongue: 46.3 nTPM (protected, limit 2); kidney: 45.7 nTPM (vital, limit 1); colon: 43.6 nTPM (protected, limit 2); lymph node: 43.6 nTPM (protected, limit 2); parathyroid gland: 43.5 nTPM (protected, limit 2); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); adipose tissue: 36.6 nTPM (manageable, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 2); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); spleen: 30.6 nTPM (manageable, limit 5); salivary gland: 30.3 nTPM (protected, limit 2); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); skin: 23.4 nTPM (manageable, limit 5); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: High (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / eccrine glands: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: High (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: High (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151247,EIF4E,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.3844% (minimum 65%, Missing); adrenal gland: 62.5773% (minimum 75%, Missing); amygdala: 70.3360% (minimum 75%, Missing); basal ganglia: 71.4959% (minimum 75%, Missing); bone marrow: 51.7477% (minimum 75%, Missing); cerebellum: 73.4867% (minimum 75%, Missing); cerebral cortex: 62.5129% (minimum 75%, Missing); choroid plexus: 66.4114% (minimum 75%, Missing); colon: 58.1975% (minimum 70%, Missing); duodenum: 63.4274% (minimum 75%, Missing); esophagus: 54.8329% (minimum 70%, Missing); heart muscle: 62.6419% (minimum 75%, Missing); hippocampal formation: 72.8691% (minimum 75%, Missing); hypothalamus: 66.7033% (minimum 75%, Missing); kidney: 57.0489% (minimum 75%, Missing); liver: 59.1042% (minimum 75%, Missing); lung: 69.8504% (minimum 75%, Missing); lymph node: 58.1975% (minimum 70%, Missing); midbrain: 67.4444% (minimum 75%, Missing); pancreas: 69.7701% (minimum 75%, Missing); parathyroid gland: 58.2534% (minimum 70%, Missing); rectum: 54.5373% (minimum 70%, Missing); retina: 53.6693% (minimum 75%, Missing); salivary gland: 66.7033% (minimum 70%, Missing); skeletal muscle: 61.6244% (minimum 75%, Missing); small intestine: 64.4374% (minimum 75%, Missing); smooth muscle: 61.5619% (minimum 75%, Missing); spinal cord: 62.9668% (minimum 75%, Missing); stomach: 63.4937% (minimum 70%, Missing); thymus: 53.9556% (minimum 65%, Missing); thyroid gland: 54.3420% (minimum 65%, Missing); tongue: 56.7290% (minimum 70%, Missing); urinary bladder: 53.6693% (minimum 70%, Missing)",-0.110444,-0.163307,-0.232523,0,9,partial,56.6,52.4,51.8,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 3); retina: 52.4 nTPM (vital, limit 1); thymus: 51.8 nTPM (manageable, limit 5); thyroid gland: 51 nTPM (manageable, limit 5); rectum: 50.6 nTPM (protected, limit 3); esophagus: 50 nTPM (protected, limit 3); tongue: 46.3 nTPM (protected, limit 3); kidney: 45.7 nTPM (vital, limit 1); colon: 43.6 nTPM (protected, limit 3); lymph node: 43.6 nTPM (protected, limit 3); parathyroid gland: 43.5 nTPM (protected, limit 3); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); adipose tissue: 36.6 nTPM (manageable, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 3); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); spleen: 30.6 nTPM (manageable, limit 5); salivary gland: 30.3 nTPM (protected, limit 3); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); skin: 23.4 nTPM (manageable, limit 5); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: High (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / eccrine glands: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: High (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: High (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151247,EIF4E,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.3844% (minimum 65%, Missing); adrenal gland: 62.5773% (minimum 75%, Missing); amygdala: 70.3360% (minimum 75%, Missing); basal ganglia: 71.4959% (minimum 75%, Missing); bone marrow: 51.7477% (minimum 75%, Missing); cerebellum: 73.4867% (minimum 75%, Missing); cerebral cortex: 62.5129% (minimum 75%, Missing); choroid plexus: 66.4114% (minimum 75%, Missing); colon: 58.1975% (minimum 70%, Missing); duodenum: 63.4274% (minimum 75%, Missing); esophagus: 54.8329% (minimum 70%, Missing); heart muscle: 62.6419% (minimum 75%, Missing); hippocampal formation: 72.8691% (minimum 75%, Missing); hypothalamus: 66.7033% (minimum 75%, Missing); kidney: 57.0489% (minimum 75%, Missing); liver: 59.1042% (minimum 75%, Missing); lung: 69.8504% (minimum 75%, Missing); lymph node: 58.1975% (minimum 70%, Missing); midbrain: 67.4444% (minimum 75%, Missing); pancreas: 69.7701% (minimum 75%, Missing); parathyroid gland: 58.2534% (minimum 70%, Missing); rectum: 54.5373% (minimum 70%, Missing); retina: 53.6693% (minimum 75%, Missing); salivary gland: 66.7033% (minimum 70%, Missing); skeletal muscle: 61.6244% (minimum 75%, Missing); small intestine: 64.4374% (minimum 75%, Missing); smooth muscle: 61.5619% (minimum 75%, Missing); spinal cord: 62.9668% (minimum 75%, Missing); stomach: 63.4937% (minimum 70%, Missing); thymus: 53.9556% (minimum 65%, Missing); thyroid gland: 54.3420% (minimum 65%, Missing); tongue: 56.7290% (minimum 70%, Missing); urinary bladder: 53.6693% (minimum 70%, Missing)",-0.110444,-0.163307,-0.232523,0,9,partial,56.6,52.4,51.8,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 3); retina: 52.4 nTPM (vital, limit 1); thymus: 51.8 nTPM (manageable, limit 5); thyroid gland: 51 nTPM (manageable, limit 5); rectum: 50.6 nTPM (protected, limit 3); esophagus: 50 nTPM (protected, limit 3); tongue: 46.3 nTPM (protected, limit 3); kidney: 45.7 nTPM (vital, limit 1); colon: 43.6 nTPM (protected, limit 3); lymph node: 43.6 nTPM (protected, limit 3); parathyroid gland: 43.5 nTPM (protected, limit 3); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); adipose tissue: 36.6 nTPM (manageable, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 3); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); spleen: 30.6 nTPM (manageable, limit 5); salivary gland: 30.3 nTPM (protected, limit 3); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); skin: 23.4 nTPM (manageable, limit 5); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: High (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / eccrine glands: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: High (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: High (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151247,EIF4E,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.3844% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.5773% (minimum 75%, Baseline (adaptation disabled)); amygdala: 70.3360% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.4959% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 51.7477% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.4867% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.5129% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.4114% (minimum 75%, Baseline (adaptation disabled)); colon: 58.1975% (minimum 70%, Baseline (adaptation disabled)); duodenum: 63.4274% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.8329% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 62.6419% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.8691% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.7033% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.0489% (minimum 75%, Baseline (adaptation disabled)); liver: 59.1042% (minimum 75%, Baseline (adaptation disabled)); lung: 69.8504% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.1975% (minimum 70%, Baseline (adaptation disabled)); midbrain: 67.4444% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.7701% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.2534% (minimum 70%, Baseline (adaptation disabled)); rectum: 54.5373% (minimum 70%, Baseline (adaptation disabled)); retina: 53.6693% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.7033% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 61.6244% (minimum 75%, Baseline (adaptation disabled)); small intestine: 64.4374% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.5619% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.9668% (minimum 75%, Baseline (adaptation disabled)); stomach: 63.4937% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.9556% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.3420% (minimum 65%, Baseline (adaptation disabled)); tongue: 56.7290% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 53.6693% (minimum 70%, Baseline (adaptation disabled))",-0.110444,-0.163307,-0.232523,0,9,partial,56.6,52.4,51.8,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 3); retina: 52.4 nTPM (vital, limit 1); thymus: 51.8 nTPM (manageable, limit 5); thyroid gland: 51 nTPM (manageable, limit 5); rectum: 50.6 nTPM (protected, limit 3); esophagus: 50 nTPM (protected, limit 3); tongue: 46.3 nTPM (protected, limit 3); kidney: 45.7 nTPM (vital, limit 1); colon: 43.6 nTPM (protected, limit 3); lymph node: 43.6 nTPM (protected, limit 3); parathyroid gland: 43.5 nTPM (protected, limit 3); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); adipose tissue: 36.6 nTPM (manageable, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 3); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); spleen: 30.6 nTPM (manageable, limit 5); salivary gland: 30.3 nTPM (protected, limit 3); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); skin: 23.4 nTPM (manageable, limit 5); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: High (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / eccrine glands: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: High (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: High (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151247,EIF4E,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.7107% (minimum 99%, Missing); basal ganglia: 95.3600% (minimum 99%, Missing); bone marrow: 89.3553% (minimum 95%, Enhanced); cerebellum: 91.6923% (minimum 95%, Enhanced); cerebral cortex: 92.3315% (minimum 95%, Enhanced); choroid plexus: 94.8290% (minimum 99%, Missing); heart muscle: 93.1250% (minimum 95%, Enhanced); hippocampal formation: 94.8290% (minimum 99%, Missing); hypothalamus: 92.6185% (minimum 99%, Missing); kidney: 86.5650% (minimum 95%, Enhanced); liver: 75.4430% (minimum 95%, Enhanced); lymph node: 91.1315% (minimum 97%, Missing); midbrain: 93.8583% (minimum 99%, Missing); pituitary gland: 94.4532% (minimum 99%, Missing); retina: 94.2292% (minimum 99%, Missing); skeletal muscle: 92.6905% (minimum 95%, Enhanced); skin: 94.2292% (minimum 95%, Missing); smooth muscle: 94.4532% (minimum 95%, Enhanced); spinal cord: 93.8583% (minimum 99%, Missing); thymus: 88.3617% (minimum 95%, Missing); tongue: 92.9797% (minimum 97%, Missing)",-0.0663825,-0.058685,-0.19557,0,8,partial,38.8,11.6,15.7,"liver: 38.8 nTPM (vital, limit 6); kidney: 18.5 nTPM (vital, limit 6); thymus: 15.7 nTPM (manageable, limit 5); bone marrow: 14.2 nTPM (vital, limit 6); lymph node: 11.6 nTPM (protected, limit 2); cerebellum: 10.8 nTPM (vital, limit 6); cerebral cortex: 9.9 nTPM (vital, limit 6); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 6); tongue: 9 nTPM (protected, limit 2); heart muscle: 8.8 nTPM (vital, limit 6); amygdala: 8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 6); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1)",skin 1 / cells in corneal layer: High (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 2 / cells in corneal layer; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151287,TEX30,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.233617,0.211315,0.15443,0,8,partial,38.8,11.6,15.7,"liver: 38.8 nTPM (vital, limit 6); kidney: 18.5 nTPM (vital, limit 6); thymus: 15.7 nTPM (manageable, limit 5); bone marrow: 14.2 nTPM (vital, limit 6); lymph node: 11.6 nTPM (protected, limit 2); cerebellum: 10.8 nTPM (vital, limit 6); cerebral cortex: 9.9 nTPM (vital, limit 6); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 6); tongue: 9 nTPM (protected, limit 2); heart muscle: 8.8 nTPM (vital, limit 6); amygdala: 8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 6); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1)",skin 1 / cells in corneal layer: High (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 2 / cells in corneal layer; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151287,TEX30,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.233617,0.211315,0.15443,0,8,partial,38.8,11.6,15.7,"liver: 38.8 nTPM (vital, limit 6); kidney: 18.5 nTPM (vital, limit 6); thymus: 15.7 nTPM (manageable, limit 5); bone marrow: 14.2 nTPM (vital, limit 6); lymph node: 11.6 nTPM (protected, limit 3); cerebellum: 10.8 nTPM (vital, limit 6); cerebral cortex: 9.9 nTPM (vital, limit 6); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 6); tongue: 9 nTPM (protected, limit 3); heart muscle: 8.8 nTPM (vital, limit 6); amygdala: 8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 6); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1)",skin 1 / cells in corneal layer: High (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 2 / cells in corneal layer; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151287,TEX30,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.233617,0.211315,0.15443,0,8,partial,38.8,11.6,15.7,"liver: 38.8 nTPM (vital, limit 6); kidney: 18.5 nTPM (vital, limit 6); thymus: 15.7 nTPM (manageable, limit 5); bone marrow: 14.2 nTPM (vital, limit 6); lymph node: 11.6 nTPM (protected, limit 3); cerebellum: 10.8 nTPM (vital, limit 6); cerebral cortex: 9.9 nTPM (vital, limit 6); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 6); tongue: 9 nTPM (protected, limit 3); heart muscle: 8.8 nTPM (vital, limit 6); amygdala: 8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 6); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1)",skin 1 / cells in corneal layer: High (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 2 / cells in corneal layer; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151287,TEX30,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.233617,0.211315,0.00443038,0,8,partial,38.8,11.6,15.7,"liver: 38.8 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); thymus: 15.7 nTPM (manageable, limit 5); bone marrow: 14.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 3); cerebellum: 10.8 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 3); amygdala: 8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); retina: 7.3 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 3); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); spleen: 6.3 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 3); colon: 5.4 nTPM (protected, limit 3); duodenum: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 3)",skin 1 / cells in corneal layer: High (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 2 / cells in corneal layer; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151287,TEX30,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.3585% (minimum 95%, Missing); adrenal gland: 73.8739% (minimum 99%, Missing); amygdala: 86.3158% (minimum 99%, Missing); basal ganglia: 85.4167% (minimum 99%, Missing); bone marrow: 92.1348% (minimum 95%, Enhanced); cerebellum: 95.3488% (minimum 99%, Missing); cerebral cortex: 80.3922% (minimum 99%, Missing); choroid plexus: 84.5361% (minimum 99%, Missing); colon: 76.6355% (minimum 97%, Missing); duodenum: 83.6735% (minimum 99%, Missing); esophagus: 73.2143% (minimum 97%, Missing); heart muscle: 75.2294% (minimum 99%, Missing); hippocampal formation: 87.2340% (minimum 99%, Missing); hypothalamus: 83.6735% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 82.8283% (minimum 99%, Missing); lung: 76.6355% (minimum 99%, Missing); lymph node: 95.3488% (minimum 97%, Missing); midbrain: 84.5361% (minimum 99%, Missing); pancreas: 66.1290% (minimum 99%, Missing); parathyroid gland: 55.0336% (minimum 97%, Missing); pituitary gland: 75.9259% (minimum 99%, Missing); rectum: 80.3922% (minimum 97%, Missing); retina: 73.2143% (minimum 99%, Missing); salivary gland: 72.5664% (minimum 97%, Missing); skeletal muscle: 81.1881% (minimum 99%, Missing); skin: 83.6735% (minimum 95%, Missing); small intestine: 84.5361% (minimum 99%, Missing); smooth muscle: 71.3043% (minimum 99%, Missing); spinal cord: 80.3922% (minimum 99%, Missing); spleen: 85.4167% (minimum 95%, Missing); stomach: 70.0855% (minimum 97%, Missing); thymus: 90.1099% (minimum 95%, Missing); thyroid gland: 59.4203% (minimum 95%, Missing); tongue: 75.2294% (minimum 97%, Missing); urinary bladder: 71.9298% (minimum 97%, Missing)",-0.355797,-0.419664,-0.32871,0,3,partial,4.2,6.7,5.6,"parathyroid gland: 6.7 nTPM (protected, limit 2); thyroid gland: 5.6 nTPM (manageable, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); lung: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151338,MIPOL1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.8739% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); pancreas: 66.1290% (minimum 75%, Missing); parathyroid gland: 55.0336% (minimum 70%, Missing); retina: 73.2143% (minimum 75%, Missing); smooth muscle: 71.3043% (minimum 75%, Missing); thyroid gland: 59.4203% (minimum 65%, Missing)",-0.0557971,-0.149664,-0.0887097,0,3,partial,4.2,6.7,5.6,"parathyroid gland: 6.7 nTPM (protected, limit 2); thyroid gland: 5.6 nTPM (manageable, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); lung: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151338,MIPOL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.8739% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); pancreas: 66.1290% (minimum 75%, Missing); parathyroid gland: 55.0336% (minimum 70%, Missing); retina: 73.2143% (minimum 75%, Missing); smooth muscle: 71.3043% (minimum 75%, Missing); thyroid gland: 59.4203% (minimum 65%, Missing)",-0.0557971,-0.149664,-0.0887097,0,3,partial,4.2,6.7,5.6,"parathyroid gland: 6.7 nTPM (protected, limit 3); thyroid gland: 5.6 nTPM (manageable, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 3); salivary gland: 3.1 nTPM (protected, limit 3); retina: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151338,MIPOL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.8739% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); pancreas: 66.1290% (minimum 75%, Missing); parathyroid gland: 55.0336% (minimum 70%, Missing); retina: 73.2143% (minimum 75%, Missing); smooth muscle: 71.3043% (minimum 75%, Missing); thyroid gland: 59.4203% (minimum 65%, Missing)",-0.0557971,-0.149664,-0.0887097,0,3,partial,4.2,6.7,5.6,"parathyroid gland: 6.7 nTPM (protected, limit 3); thyroid gland: 5.6 nTPM (manageable, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 3); salivary gland: 3.1 nTPM (protected, limit 3); retina: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151338,MIPOL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.8739% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.1290% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.0336% (minimum 70%, Baseline (adaptation disabled)); retina: 73.2143% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.3043% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 59.4203% (minimum 65%, Baseline (adaptation disabled))",-0.0557971,-0.149664,-0.0887097,0,3,partial,4.2,6.7,5.6,"parathyroid gland: 6.7 nTPM (protected, limit 3); thyroid gland: 5.6 nTPM (manageable, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 3); salivary gland: 3.1 nTPM (protected, limit 3); retina: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151338,MIPOL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 97.5610% (minimum 99%, Missing); liver: 96.3855% (minimum 99%, Missing)",0.0437888,0.03,-0.0261446,0,80,unavailable,0.6,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151360,ALLC,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343789,0.3,0.213855,0,80,unavailable,0.6,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151360,ALLC,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343789,0.3,0.213855,0,80,unavailable,0.6,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151360,ALLC,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343789,0.3,0.213855,0,80,unavailable,0.6,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151360,ALLC,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343789,0.3,0.213855,0,80,unavailable,0.6,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151360,ALLC,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.00782609,0,0,routine_complete,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151475,SLC25A31,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.247826,0,0,routine_complete,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151475,SLC25A31,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.247826,0,0,routine_complete,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151475,SLC25A31,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.247826,0,0,routine_complete,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151475,SLC25A31,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.247826,0,0,routine_complete,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151475,SLC25A31,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.0635% (minimum 95%, Missing); adrenal gland: 78.9116% (minimum 99%, Missing); amygdala: 80.5556% (minimum 99%, Missing); basal ganglia: 75.8170% (minimum 99%, Missing); bone marrow: 94.3089% (minimum 99%, Missing); cerebellum: 93.5484% (minimum 99%, Missing); cerebral cortex: 87.8788% (minimum 99%, Missing); choroid plexus: 63.0435% (minimum 99%, Missing); colon: 86.5672% (minimum 97%, Missing); duodenum: 68.2353% (minimum 99%, Missing); esophagus: 78.3784% (minimum 97%, Missing); heart muscle: 95.0820% (minimum 99%, Missing); hippocampal formation: 76.8212% (minimum 99%, Missing); hypothalamus: 71.1656% (minimum 99%, Missing); kidney: 64.8045% (minimum 99%, Missing); liver: 94.3089% (minimum 99%, Missing); lung: 84.0580% (minimum 99%, Missing); lymph node: 81.1189% (minimum 97%, Missing); midbrain: 81.1189% (minimum 99%, Missing); pancreas: 80.0000% (minimum 99%, Missing); parathyroid gland: 63.7363% (minimum 97%, Missing); pituitary gland: 56.3107% (minimum 99%, Missing); rectum: 84.0580% (minimum 97%, Missing); retina: 67.0520% (minimum 99%, Missing); salivary gland: 62.3656% (minimum 97%, Missing); skeletal muscle: 97.4790% (minimum 99%, Missing); skin: 83.4532% (minimum 95%, Missing); small intestine: 75.3247% (minimum 99%, Missing); smooth muscle: 92.8000% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 85.2941% (minimum 95%, Missing); stomach: 67.8363% (minimum 97%, Missing); thymus: 88.5496% (minimum 95%, Missing); thyroid gland: 59.7938% (minimum 95%, Missing); tongue: 95.0820% (minimum 97%, Missing); urinary bladder: 88.5496% (minimum 97%, Missing)",-0.352062,-0.346344,-0.426893,0,80,unavailable,9,7,7.8,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); salivary gland: 7 nTPM (protected, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151575,TEX9,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.0435% (minimum 75%, Missing); duodenum: 68.2353% (minimum 75%, Missing); hypothalamus: 71.1656% (minimum 75%, Missing); kidney: 64.8045% (minimum 75%, Missing); parathyroid gland: 63.7363% (minimum 70%, Missing); pituitary gland: 56.3107% (minimum 75%, Missing); retina: 67.0520% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); stomach: 67.8363% (minimum 70%, Missing); thyroid gland: 59.7938% (minimum 65%, Missing)",-0.0520619,-0.0763441,-0.186893,0,80,unavailable,9,7,7.8,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); salivary gland: 7 nTPM (protected, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151575,TEX9,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.0435% (minimum 75%, Missing); duodenum: 68.2353% (minimum 75%, Missing); hypothalamus: 71.1656% (minimum 75%, Missing); kidney: 64.8045% (minimum 75%, Missing); parathyroid gland: 63.7363% (minimum 70%, Missing); pituitary gland: 56.3107% (minimum 75%, Missing); retina: 67.0520% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); stomach: 67.8363% (minimum 70%, Missing); thyroid gland: 59.7938% (minimum 65%, Missing)",-0.0520619,-0.0763441,-0.186893,0,80,unavailable,9,7,7.8,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); salivary gland: 7 nTPM (protected, limit 3); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 3); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 3); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151575,TEX9,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.0435% (minimum 75%, Missing); duodenum: 68.2353% (minimum 75%, Missing); hypothalamus: 71.1656% (minimum 75%, Missing); kidney: 64.8045% (minimum 75%, Missing); parathyroid gland: 63.7363% (minimum 70%, Missing); pituitary gland: 56.3107% (minimum 75%, Missing); retina: 67.0520% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); stomach: 67.8363% (minimum 70%, Missing); thyroid gland: 59.7938% (minimum 65%, Missing)",-0.0520619,-0.0763441,-0.186893,0,80,unavailable,9,7,7.8,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); salivary gland: 7 nTPM (protected, limit 3); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 3); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 3); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151575,TEX9,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.0435% (minimum 75%, Baseline (adaptation disabled)); duodenum: 68.2353% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.1656% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.8045% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.7363% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 56.3107% (minimum 75%, Baseline (adaptation disabled)); retina: 67.0520% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.3656% (minimum 70%, Baseline (adaptation disabled)); stomach: 67.8363% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 59.7938% (minimum 65%, Baseline (adaptation disabled))",-0.0520619,-0.0763441,-0.186893,0,80,unavailable,9,7,7.8,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); salivary gland: 7 nTPM (protected, limit 3); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 3); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 3); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151575,TEX9,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 15.7895% (minimum 99%, Missing); hypothalamus: 85.7143% (minimum 99%, Missing); retina: 85.7143% (minimum 99%, Missing)",0.05,0.03,-0.832105,0,80,unavailable,3.2,0,0,"basal ganglia: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151577,DRD3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 15.7895% (minimum 75%, Missing)",0.35,0.3,-0.592105,0,80,unavailable,3.2,0,0,"basal ganglia: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151577,DRD3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 15.7895% (minimum 75%, Missing)",0.35,0.3,-0.592105,0,80,unavailable,3.2,0,0,"basal ganglia: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151577,DRD3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 15.7895% (minimum 75%, Missing)",0.35,0.3,-0.592105,0,80,unavailable,3.2,0,0,"basal ganglia: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151577,DRD3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 15.7895% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.592105,0,80,unavailable,3.2,0,0,"basal ganglia: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151577,DRD3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 83.3333% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing)",0.05,0.03,-0.49,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151615,POU4F2,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151615,POU4F2,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151615,POU4F2,grid_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151615,POU4F2,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.25,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151615,POU4F2,current_fixed,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 93.3333% (minimum 99%, Missing); bone marrow: 96.5517% (minimum 99%, Missing); choroid plexus: 96.5517% (minimum 99%, Missing); colon: 96.5517% (minimum 97%, Missing); duodenum: 96.5517% (minimum 99%, Missing); heart muscle: 98.2456% (minimum 99%, Missing); kidney: 96.5517% (minimum 99%, Missing); liver: 94.9153% (minimum 99%, Missing); lung: 94.9153% (minimum 99%, Missing); lymph node: 91.8033% (minimum 97%, Missing); pancreas: 91.8033% (minimum 99%, Missing); parathyroid gland: 90.3226% (minimum 97%, Missing); pituitary gland: 98.2456% (minimum 99%, Missing); rectum: 93.3333% (minimum 97%, Missing); retina: 90.3226% (minimum 99%, Missing); salivary gland: 91.8033% (minimum 97%, Missing); skeletal muscle: 98.2456% (minimum 99%, Missing); skin: 94.9153% (minimum 95%, Missing); small intestine: 94.9153% (minimum 99%, Missing); smooth muscle: 96.5517% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Missing); stomach: 91.8033% (minimum 97%, Missing); thyroid gland: 91.8033% (minimum 95%, Missing); urinary bladder: 96.5517% (minimum 97%, Missing)",-0.0319672,-0.0667742,-0.0867742,0,80,unavailable,0.6,0.6,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151687,ANKAR,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.268033,0.203226,0.153226,0,80,unavailable,0.6,0.6,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151687,ANKAR,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.268033,0.203226,0.153226,0,80,unavailable,0.6,0.6,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151687,ANKAR,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.268033,0.203226,0.153226,0,80,unavailable,0.6,0.6,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151687,ANKAR,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.268033,0.203226,0.153226,0,80,unavailable,0.6,0.6,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151687,ANKAR,current_fixed,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.2963% (minimum 99%, Missing); amygdala: 98.9619% (minimum 99%, Missing); basal ganglia: 98.9619% (minimum 99%, Missing); bone marrow: 31.6372% (minimum 99%, Missing); cerebellum: 98.2818% (minimum 99%, Missing); cerebral cortex: 96.6216% (minimum 99%, Missing); choroid plexus: 98.6207% (minimum 99%, Missing); colon: 79.2244% (minimum 97%, Missing); duodenum: 85.3731% (minimum 99%, Missing); esophagus: 73.9018% (minimum 97%, Missing); heart muscle: 95.3333% (minimum 99%, Missing); hippocampal formation: 98.9619% (minimum 99%, Missing); kidney: 97.6109% (minimum 99%, Missing); liver: 88.8199% (minimum 99%, Missing); lung: 94.3894% (minimum 99%, Missing); lymph node: 64.4144% (minimum 97%, Missing); midbrain: 98.9619% (minimum 99%, Missing); pancreas: 96.9492% (minimum 99%, Missing); parathyroid gland: 95.3333% (minimum 97%, Missing); rectum: 78.5714% (minimum 97%, Missing); retina: 95.0166% (minimum 99%, Missing); salivary gland: 91.6667% (minimum 97%, Missing); skeletal muscle: 96.9492% (minimum 99%, Missing); skin: 65.7471% (minimum 95%, Missing); small intestine: 84.6154% (minimum 99%, Missing); smooth muscle: 91.6667% (minimum 99%, Missing); spinal cord: 98.2818% (minimum 99%, Missing); spleen: 92.5566% (minimum 95%, Missing); stomach: 88.8199% (minimum 97%, Missing); thymus: 69.5864% (minimum 95%, Missing); urinary bladder: 93.4641% (minimum 97%, Missing)",-0.292529,-0.325856,-0.673628,0,80,unavailable,61.8,15.8,14.9,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 2); skin: 14.9 nTPM (manageable, limit 5); thymus: 12.5 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 2); rectum: 7.8 nTPM (protected, limit 2); colon: 7.5 nTPM (protected, limit 2); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151725,CENPU,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 31.6372% (minimum 75%, Missing); lymph node: 64.4144% (minimum 70%, Missing)",0.00747126,-0.0558559,-0.433628,0,80,unavailable,61.8,15.8,14.9,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 2); skin: 14.9 nTPM (manageable, limit 5); thymus: 12.5 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 2); rectum: 7.8 nTPM (protected, limit 2); colon: 7.5 nTPM (protected, limit 2); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151725,CENPU,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 31.6372% (minimum 75%, Missing); lymph node: 64.4144% (minimum 70%, Missing)",0.00747126,-0.0558559,-0.433628,0,80,unavailable,61.8,15.8,14.9,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 3); skin: 14.9 nTPM (manageable, limit 5); thymus: 12.5 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 3); rectum: 7.8 nTPM (protected, limit 3); colon: 7.5 nTPM (protected, limit 3); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151725,CENPU,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 31.6372% (minimum 75%, Missing); lymph node: 64.4144% (minimum 70%, Missing)",0.00747126,-0.0558559,-0.433628,0,80,unavailable,61.8,15.8,14.9,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 3); skin: 14.9 nTPM (manageable, limit 5); thymus: 12.5 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 3); rectum: 7.8 nTPM (protected, limit 3); colon: 7.5 nTPM (protected, limit 3); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151725,CENPU,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 31.6372% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.4144% (minimum 70%, Baseline (adaptation disabled))",0.00747126,-0.0558559,-0.433628,0,80,unavailable,61.8,15.8,14.9,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 3); skin: 14.9 nTPM (manageable, limit 5); thymus: 12.5 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 3); rectum: 7.8 nTPM (protected, limit 3); colon: 7.5 nTPM (protected, limit 3); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151725,CENPU,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.6667% (minimum 90%, Approved); adrenal gland: 65.4321% (minimum 99%, Missing); amygdala: 80.3030% (minimum 99%, Missing); basal ganglia: 76.8116% (minimum 99%, Missing); bone marrow: 85.4839% (minimum 98%, Approved); cerebellum: 89.8305% (minimum 99%, Missing); cerebral cortex: 76.8116% (minimum 99%, Missing); choroid plexus: 88.3333% (minimum 99%, Missing); colon: 65.4321% (minimum 97%, Missing); duodenum: 76.8116% (minimum 99%, Missing); esophagus: 72.6027% (minimum 97%, Missing); heart muscle: 54.0816% (minimum 99%, Missing); hippocampal formation: 74.6479% (minimum 99%, Missing); hypothalamus: 77.9412% (minimum 99%, Missing); kidney: 64.6341% (minimum 99%, Missing); liver: 69.7368% (minimum 99%, Missing); lung: 72.6027% (minimum 99%, Missing); lymph node: 66.2500% (minimum 97%, Missing); midbrain: 74.6479% (minimum 99%, Missing); pancreas: 60.2273% (minimum 98%, Approved); parathyroid gland: 57.6087% (minimum 95%, Approved); pituitary gland: 63.0952% (minimum 99%, Missing); rectum: 60.9195% (minimum 97%, Missing); retina: 89.8305% (minimum 99%, Missing); salivary gland: 63.0952% (minimum 97%, Missing); skeletal muscle: 84.1270% (minimum 99%, Missing); skin: 57.6087% (minimum 95%, Missing); small intestine: 68.8312% (minimum 99%, Missing); smooth muscle: 62.3529% (minimum 99%, Missing); spinal cord: 73.6111% (minimum 99%, Missing); spleen: 64.6341% (minimum 90%, Approved); stomach: 63.8554% (minimum 97%, Missing); thymus: 72.6027% (minimum 95%, Missing); thyroid gland: 52.4752% (minimum 95%, Missing); tongue: 94.6429% (minimum 97%, Missing); urinary bladder: 65.4321% (minimum 97%, Missing)",-0.425248,-0.373913,-0.449184,0,1,partial,4.5,3.9,4.8,"heart muscle: 4.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 2); rectum: 3.4 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151773,CCDC122,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.4321% (minimum 75%, Missing); colon: 65.4321% (minimum 70%, Missing); heart muscle: 54.0816% (minimum 75%, Missing); hippocampal formation: 74.6479% (minimum 75%, Missing); kidney: 64.6341% (minimum 75%, Missing); liver: 69.7368% (minimum 75%, Missing); lung: 72.6027% (minimum 75%, Missing); lymph node: 66.2500% (minimum 70%, Missing); midbrain: 74.6479% (minimum 75%, Missing); pancreas: 60.2273% (minimum 70%, Approved); parathyroid gland: 57.6087% (minimum 65%, Approved); pituitary gland: 63.0952% (minimum 75%, Missing); rectum: 60.9195% (minimum 70%, Missing); salivary gland: 63.0952% (minimum 70%, Missing); skin: 57.6087% (minimum 65%, Missing); small intestine: 68.8312% (minimum 75%, Missing); smooth muscle: 62.3529% (minimum 75%, Missing); spinal cord: 73.6111% (minimum 75%, Missing); stomach: 63.8554% (minimum 70%, Missing); thyroid gland: 52.4752% (minimum 65%, Missing); urinary bladder: 65.4321% (minimum 70%, Missing)",-0.125248,-0.0908046,-0.209184,0,1,partial,4.5,3.9,4.8,"heart muscle: 4.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 2); rectum: 3.4 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151773,CCDC122,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.4321% (minimum 75%, Missing); colon: 65.4321% (minimum 70%, Missing); heart muscle: 54.0816% (minimum 75%, Missing); hippocampal formation: 74.6479% (minimum 75%, Missing); kidney: 64.6341% (minimum 75%, Missing); liver: 69.7368% (minimum 75%, Missing); lung: 72.6027% (minimum 75%, Missing); lymph node: 66.2500% (minimum 70%, Missing); midbrain: 74.6479% (minimum 75%, Missing); pancreas: 60.2273% (minimum 70%, Approved); parathyroid gland: 57.6087% (minimum 65%, Approved); pituitary gland: 63.0952% (minimum 75%, Missing); rectum: 60.9195% (minimum 70%, Missing); salivary gland: 63.0952% (minimum 70%, Missing); skin: 57.6087% (minimum 65%, Missing); small intestine: 68.8312% (minimum 75%, Missing); smooth muscle: 62.3529% (minimum 75%, Missing); spinal cord: 73.6111% (minimum 75%, Missing); stomach: 63.8554% (minimum 70%, Missing); thyroid gland: 52.4752% (minimum 65%, Missing); urinary bladder: 65.4321% (minimum 70%, Missing)",-0.125248,-0.0908046,-0.209184,0,1,partial,4.5,3.9,4.8,"heart muscle: 4.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 2); rectum: 3.4 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151773,CCDC122,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.4321% (minimum 75%, Missing); colon: 65.4321% (minimum 70%, Missing); heart muscle: 54.0816% (minimum 75%, Missing); hippocampal formation: 74.6479% (minimum 75%, Missing); kidney: 64.6341% (minimum 75%, Missing); liver: 69.7368% (minimum 75%, Missing); lung: 72.6027% (minimum 75%, Missing); lymph node: 66.2500% (minimum 70%, Missing); midbrain: 74.6479% (minimum 75%, Missing); pancreas: 60.2273% (minimum 70%, Approved); parathyroid gland: 57.6087% (minimum 65%, Approved); pituitary gland: 63.0952% (minimum 75%, Missing); rectum: 60.9195% (minimum 70%, Missing); salivary gland: 63.0952% (minimum 70%, Missing); skin: 57.6087% (minimum 65%, Missing); small intestine: 68.8312% (minimum 75%, Missing); smooth muscle: 62.3529% (minimum 75%, Missing); spinal cord: 73.6111% (minimum 75%, Missing); stomach: 63.8554% (minimum 70%, Missing); thyroid gland: 52.4752% (minimum 65%, Missing); urinary bladder: 65.4321% (minimum 70%, Missing)",-0.125248,-0.0908046,-0.209184,0,1,partial,4.5,3.9,4.8,"heart muscle: 4.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 2); rectum: 3.4 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151773,CCDC122,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.4321% (minimum 75%, Baseline (adaptation disabled)); colon: 65.4321% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 54.0816% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.6479% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.6341% (minimum 75%, Baseline (adaptation disabled)); liver: 69.7368% (minimum 75%, Baseline (adaptation disabled)); lung: 72.6027% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.2500% (minimum 70%, Baseline (adaptation disabled)); midbrain: 74.6479% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.2273% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.6087% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.0952% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.9195% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 63.0952% (minimum 70%, Baseline (adaptation disabled)); skin: 57.6087% (minimum 65%, Baseline (adaptation disabled)); small intestine: 68.8312% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.3529% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.6111% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.6341% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.8554% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 52.4752% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 65.4321% (minimum 70%, Baseline (adaptation disabled))",-0.125248,-0.123913,-0.209184,0,1,partial,4.5,3.9,4.8,"heart muscle: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); pancreas: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151773,CCDC122,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.5833% (minimum 95%, Missing); adrenal gland: 96.8750% (minimum 99%, Missing); amygdala: 80.5195% (minimum 99%, Missing); basal ganglia: 76.5432% (minimum 99%, Missing); bone marrow: 96.8750% (minimum 99%, Missing); cerebellum: 46.2687% (minimum 99%, Missing); cerebral cortex: 62.0000% (minimum 99%, Missing); choroid plexus: 84.9315% (minimum 99%, Missing); colon: 88.5714% (minimum 97%, Missing); duodenum: 96.8750% (minimum 99%, Missing); esophagus: 75.6098% (minimum 97%, Missing); heart muscle: 78.4810% (minimum 99%, Missing); hippocampal formation: 82.6667% (minimum 99%, Missing); hypothalamus: 82.6667% (minimum 99%, Missing); kidney: 78.4810% (minimum 99%, Missing); liver: 95.3846% (minimum 99%, Missing); lung: 91.1765% (minimum 99%, Missing); lymph node: 89.8551% (minimum 97%, Missing); midbrain: 72.0930% (minimum 99%, Missing); pancreas: 93.9394% (minimum 99%, Missing); parathyroid gland: 96.8750% (minimum 97%, Missing); pituitary gland: 98.4127% (minimum 99%, Missing); rectum: 93.9394% (minimum 97%, Missing); retina: 43.9716% (minimum 99%, Missing); salivary gland: 91.1765% (minimum 97%, Missing); skeletal muscle: 84.9315% (minimum 99%, Missing); skin: 91.1765% (minimum 95%, Missing); small intestine: 92.5373% (minimum 99%, Missing); smooth muscle: 81.5789% (minimum 99%, Missing); spinal cord: 89.8551% (minimum 99%, Missing); stomach: 93.9394% (minimum 97%, Missing); thymus: 91.1765% (minimum 95%, Missing); thyroid gland: 92.5373% (minimum 95%, Missing); tongue: 63.9175% (minimum 97%, Missing); urinary bladder: 68.8889% (minimum 97%, Missing)",-0.304167,-0.330825,-0.550284,0,80,unavailable,7.9,3.5,3.4,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151789,ZNF385D,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.5833% (minimum 65%, Missing); cerebellum: 46.2687% (minimum 75%, Missing); cerebral cortex: 62.0000% (minimum 75%, Missing); midbrain: 72.0930% (minimum 75%, Missing); retina: 43.9716% (minimum 75%, Missing); tongue: 63.9175% (minimum 70%, Missing); urinary bladder: 68.8889% (minimum 70%, Missing)",-0.00416667,-0.0608247,-0.310284,0,80,unavailable,7.9,3.5,3.4,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151789,ZNF385D,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.5833% (minimum 65%, Missing); cerebellum: 46.2687% (minimum 75%, Missing); cerebral cortex: 62.0000% (minimum 75%, Missing); midbrain: 72.0930% (minimum 75%, Missing); retina: 43.9716% (minimum 75%, Missing); tongue: 63.9175% (minimum 70%, Missing); urinary bladder: 68.8889% (minimum 70%, Missing)",-0.00416667,-0.0608247,-0.310284,0,80,unavailable,7.9,3.5,3.4,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151789,ZNF385D,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.5833% (minimum 65%, Missing); cerebellum: 46.2687% (minimum 75%, Missing); cerebral cortex: 62.0000% (minimum 75%, Missing); midbrain: 72.0930% (minimum 75%, Missing); retina: 43.9716% (minimum 75%, Missing); tongue: 63.9175% (minimum 70%, Missing); urinary bladder: 68.8889% (minimum 70%, Missing)",-0.00416667,-0.0608247,-0.310284,0,80,unavailable,7.9,3.5,3.4,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151789,ZNF385D,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.5833% (minimum 65%, Baseline (adaptation disabled)); cerebellum: 46.2687% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 72.0930% (minimum 75%, Baseline (adaptation disabled)); retina: 43.9716% (minimum 75%, Baseline (adaptation disabled)); tongue: 63.9175% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 68.8889% (minimum 70%, Baseline (adaptation disabled))",-0.00416667,-0.0608247,-0.310284,0,80,unavailable,7.9,3.5,3.4,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151789,ZNF385D,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0361878,0.00808219,0.00166667,0,4,partial,0.4,0.8,0.5,,bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151846,PABPC3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.336188,0.278082,0.241667,0,4,partial,0.4,0.8,0.5,,bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151846,PABPC3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.336188,0.278082,0.241667,0,4,partial,0.4,0.8,0.5,,bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151846,PABPC3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.336188,0.278082,0.241667,0,4,partial,0.4,0.8,0.5,,bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151846,PABPC3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.336188,0.278082,0.23892,0,4,partial,0.4,0.8,0.5,,bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151846,PABPC3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.0352941,0.0262825,0.00628253,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151962,RBM46,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.335294,0.296283,0.246283,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151962,RBM46,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.335294,0.296283,0.246283,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151962,RBM46,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.335294,0.296283,0.246283,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151962,RBM46,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.335294,0.296283,0.246283,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000151962,RBM46,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 76.7913% (minimum 99%, Missing)",0.05,0.03,-0.222087,0,80,unavailable,51.5,0,0,"heart muscle: 51.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152086,TUBA3E,admission_only,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;family_exclusion,True,True,True,,0.35,0.3,0.0179135,0,80,unavailable,51.5,0,0,"heart muscle: 51.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152086,TUBA3E,selectivity_revised,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;family_exclusion,True,True,True,,0.35,0.3,0.0179135,0,80,unavailable,51.5,0,0,"heart muscle: 51.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152086,TUBA3E,grid_revised,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;family_exclusion,True,True,True,,0.35,0.3,0.0179135,0,80,unavailable,51.5,0,0,"heart muscle: 51.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152086,TUBA3E,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;family_exclusion,True,True,True,,0.35,0.3,0.0179135,0,80,unavailable,51.5,0,0,"heart muscle: 51.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152086,TUBA3E,current_fixed,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.3571% (minimum 60%, Enhanced); adrenal gland: 60.3406% (minimum 95%, Enhanced); amygdala: 47.4641% (minimum 99%, Missing); basal ganglia: 41.7508% (minimum 99%, Missing); bone marrow: 52.0462% (minimum 95%, Enhanced); cerebellum: 43.7004% (minimum 99%, Missing); cerebral cortex: 42.1053% (minimum 99%, Missing); choroid plexus: 70.2550% (minimum 99%, Missing); colon: 48.6275% (minimum 80%, Enhanced); duodenum: 65.9574% (minimum 95%, Enhanced); esophagus: 59.8311% (minimum 80%, Enhanced); heart muscle: 54.1485% (minimum 99%, Missing); hippocampal formation: 47.5551% (minimum 99%, Missing); hypothalamus: 52.3759% (minimum 99%, Missing); kidney: 57.2088% (minimum 95%, Enhanced); liver: 62.2334% (minimum 95%, Enhanced); lung: 65.0066% (minimum 95%, Enhanced); lymph node: 64.6675% (minimum 97%, Missing); midbrain: 47.5551% (minimum 99%, Missing); pancreas: 62.9442% (minimum 95%, Enhanced); parathyroid gland: 52.3207% (minimum 80%, Enhanced); pituitary gland: 71.4697% (minimum 99%, Missing); rectum: 61.6149% (minimum 80%, Enhanced); retina: 51.2927% (minimum 99%, Missing); salivary gland: 64.4993% (minimum 80%, Enhanced); skeletal muscle: 42.3932% (minimum 99%, Missing); small intestine: 59.7590% (minimum 95%, Enhanced); smooth muscle: 55.7303% (minimum 95%, Enhanced); spinal cord: 47.4641% (minimum 99%, Missing); stomach: 58.4906% (minimum 97%, Missing); thymus: 56.9460% (minimum 95%, Missing); thyroid gland: 58.5596% (minimum 95%, Missing); tongue: 49.3532% (minimum 97%, Missing); urinary bladder: 51.8286% (minimum 97%, Missing)",-0.38054,-0.476468,-0.572492,0,2,partial,69.2,52.4,40,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 12); tongue: 50.9 nTPM (protected, limit 2); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 2); bone marrow: 45.7 nTPM (vital, limit 6); parathyroid gland: 45.2 nTPM (protected, limit 12); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (manageable, limit 30); smooth muscle: 39.4 nTPM (vital, limit 6); thymus: 37.5 nTPM (manageable, limit 5); kidney: 37.1 nTPM (vital, limit 6); stomach: 35.2 nTPM (protected, limit 2); thyroid gland: 35.1 nTPM (manageable, limit 5); small intestine: 33.4 nTPM (vital, limit 6); esophagus: 33.3 nTPM (protected, limit 12); adrenal gland: 32.6 nTPM (vital, limit 6); rectum: 30.9 nTPM (protected, limit 12); liver: 30.1 nTPM (vital, limit 6); pancreas: 29.2 nTPM (vital, limit 6); salivary gland: 27.3 nTPM (protected, limit 12); lymph node: 27.1 nTPM (protected, limit 2); lung: 26.7 nTPM (vital, limit 6); duodenum: 25.6 nTPM (vital, limit 6); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152102,FAM168B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 47.4641% (minimum 75%, Missing); basal ganglia: 41.7508% (minimum 75%, Missing); bone marrow: 52.0462% (minimum 60%, Enhanced); cerebellum: 43.7004% (minimum 75%, Missing); cerebral cortex: 42.1053% (minimum 75%, Missing); choroid plexus: 70.2550% (minimum 75%, Missing); colon: 48.6275% (minimum 55%, Enhanced); heart muscle: 54.1485% (minimum 75%, Missing); hippocampal formation: 47.5551% (minimum 75%, Missing); hypothalamus: 52.3759% (minimum 75%, Missing); kidney: 57.2088% (minimum 60%, Enhanced); lymph node: 64.6675% (minimum 70%, Missing); midbrain: 47.5551% (minimum 75%, Missing); parathyroid gland: 52.3207% (minimum 55%, Enhanced); pituitary gland: 71.4697% (minimum 75%, Missing); retina: 51.2927% (minimum 75%, Missing); skeletal muscle: 42.3932% (minimum 75%, Missing); small intestine: 59.7590% (minimum 60%, Enhanced); smooth muscle: 55.7303% (minimum 60%, Enhanced); spinal cord: 47.4641% (minimum 75%, Missing); stomach: 58.4906% (minimum 70%, Missing); thymus: 56.9460% (minimum 65%, Missing); thyroid gland: 58.5596% (minimum 65%, Missing); tongue: 49.3532% (minimum 70%, Missing); urinary bladder: 51.8286% (minimum 70%, Missing)",-0.0805396,-0.206468,-0.332492,0,2,partial,69.2,52.4,40,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 12); tongue: 50.9 nTPM (protected, limit 2); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 2); bone marrow: 45.7 nTPM (vital, limit 6); parathyroid gland: 45.2 nTPM (protected, limit 12); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (manageable, limit 30); smooth muscle: 39.4 nTPM (vital, limit 6); thymus: 37.5 nTPM (manageable, limit 5); kidney: 37.1 nTPM (vital, limit 6); stomach: 35.2 nTPM (protected, limit 2); thyroid gland: 35.1 nTPM (manageable, limit 5); small intestine: 33.4 nTPM (vital, limit 6); esophagus: 33.3 nTPM (protected, limit 12); adrenal gland: 32.6 nTPM (vital, limit 6); rectum: 30.9 nTPM (protected, limit 12); liver: 30.1 nTPM (vital, limit 6); pancreas: 29.2 nTPM (vital, limit 6); salivary gland: 27.3 nTPM (protected, limit 12); lymph node: 27.1 nTPM (protected, limit 2); lung: 26.7 nTPM (vital, limit 6); duodenum: 25.6 nTPM (vital, limit 6); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152102,FAM168B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 47.4641% (minimum 75%, Missing); basal ganglia: 41.7508% (minimum 75%, Missing); bone marrow: 52.0462% (minimum 60%, Enhanced); cerebellum: 43.7004% (minimum 75%, Missing); cerebral cortex: 42.1053% (minimum 75%, Missing); choroid plexus: 70.2550% (minimum 75%, Missing); colon: 48.6275% (minimum 55%, Enhanced); heart muscle: 54.1485% (minimum 75%, Missing); hippocampal formation: 47.5551% (minimum 75%, Missing); hypothalamus: 52.3759% (minimum 75%, Missing); kidney: 57.2088% (minimum 60%, Enhanced); lymph node: 64.6675% (minimum 70%, Missing); midbrain: 47.5551% (minimum 75%, Missing); parathyroid gland: 52.3207% (minimum 55%, Enhanced); pituitary gland: 71.4697% (minimum 75%, Missing); retina: 51.2927% (minimum 75%, Missing); skeletal muscle: 42.3932% (minimum 75%, Missing); small intestine: 59.7590% (minimum 60%, Enhanced); smooth muscle: 55.7303% (minimum 60%, Enhanced); spinal cord: 47.4641% (minimum 75%, Missing); stomach: 58.4906% (minimum 70%, Missing); thymus: 56.9460% (minimum 65%, Missing); thyroid gland: 58.5596% (minimum 65%, Missing); tongue: 49.3532% (minimum 70%, Missing); urinary bladder: 51.8286% (minimum 70%, Missing)",-0.0805396,-0.206468,-0.332492,0,2,partial,69.2,52.4,40,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 12); tongue: 50.9 nTPM (protected, limit 3); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 3); bone marrow: 45.7 nTPM (vital, limit 6); parathyroid gland: 45.2 nTPM (protected, limit 12); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (manageable, limit 30); smooth muscle: 39.4 nTPM (vital, limit 6); thymus: 37.5 nTPM (manageable, limit 5); kidney: 37.1 nTPM (vital, limit 6); stomach: 35.2 nTPM (protected, limit 3); thyroid gland: 35.1 nTPM (manageable, limit 5); small intestine: 33.4 nTPM (vital, limit 6); esophagus: 33.3 nTPM (protected, limit 12); adrenal gland: 32.6 nTPM (vital, limit 6); rectum: 30.9 nTPM (protected, limit 12); liver: 30.1 nTPM (vital, limit 6); pancreas: 29.2 nTPM (vital, limit 6); salivary gland: 27.3 nTPM (protected, limit 12); lymph node: 27.1 nTPM (protected, limit 3); lung: 26.7 nTPM (vital, limit 6); duodenum: 25.6 nTPM (vital, limit 6); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152102,FAM168B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 47.4641% (minimum 75%, Missing); basal ganglia: 41.7508% (minimum 75%, Missing); bone marrow: 52.0462% (minimum 60%, Enhanced); cerebellum: 43.7004% (minimum 75%, Missing); cerebral cortex: 42.1053% (minimum 75%, Missing); choroid plexus: 70.2550% (minimum 75%, Missing); colon: 48.6275% (minimum 55%, Enhanced); heart muscle: 54.1485% (minimum 75%, Missing); hippocampal formation: 47.5551% (minimum 75%, Missing); hypothalamus: 52.3759% (minimum 75%, Missing); kidney: 57.2088% (minimum 60%, Enhanced); lymph node: 64.6675% (minimum 70%, Missing); midbrain: 47.5551% (minimum 75%, Missing); parathyroid gland: 52.3207% (minimum 55%, Enhanced); pituitary gland: 71.4697% (minimum 75%, Missing); retina: 51.2927% (minimum 75%, Missing); skeletal muscle: 42.3932% (minimum 75%, Missing); small intestine: 59.7590% (minimum 60%, Enhanced); smooth muscle: 55.7303% (minimum 60%, Enhanced); spinal cord: 47.4641% (minimum 75%, Missing); stomach: 58.4906% (minimum 70%, Missing); thymus: 56.9460% (minimum 65%, Missing); thyroid gland: 58.5596% (minimum 65%, Missing); tongue: 49.3532% (minimum 70%, Missing); urinary bladder: 51.8286% (minimum 70%, Missing)",-0.0805396,-0.206468,-0.332492,0,2,partial,69.2,52.4,40,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 12); tongue: 50.9 nTPM (protected, limit 3); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 3); bone marrow: 45.7 nTPM (vital, limit 6); parathyroid gland: 45.2 nTPM (protected, limit 12); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (manageable, limit 30); smooth muscle: 39.4 nTPM (vital, limit 6); thymus: 37.5 nTPM (manageable, limit 5); kidney: 37.1 nTPM (vital, limit 6); stomach: 35.2 nTPM (protected, limit 3); thyroid gland: 35.1 nTPM (manageable, limit 5); small intestine: 33.4 nTPM (vital, limit 6); esophagus: 33.3 nTPM (protected, limit 12); adrenal gland: 32.6 nTPM (vital, limit 6); rectum: 30.9 nTPM (protected, limit 12); liver: 30.1 nTPM (vital, limit 6); pancreas: 29.2 nTPM (vital, limit 6); salivary gland: 27.3 nTPM (protected, limit 12); lymph node: 27.1 nTPM (protected, limit 3); lung: 26.7 nTPM (vital, limit 6); duodenum: 25.6 nTPM (vital, limit 6); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152102,FAM168B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.3571% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.3406% (minimum 75%, Baseline (adaptation disabled)); amygdala: 47.4641% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 41.7508% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 52.0462% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.7004% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 42.1053% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.2550% (minimum 75%, Baseline (adaptation disabled)); colon: 48.6275% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.9574% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.8311% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 54.1485% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 47.5551% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 52.3759% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.2088% (minimum 75%, Baseline (adaptation disabled)); liver: 62.2334% (minimum 75%, Baseline (adaptation disabled)); lung: 65.0066% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.6675% (minimum 70%, Baseline (adaptation disabled)); midbrain: 47.5551% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.9442% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.3207% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.4697% (minimum 75%, Baseline (adaptation disabled)); rectum: 61.6149% (minimum 70%, Baseline (adaptation disabled)); retina: 51.2927% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.4993% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 42.3932% (minimum 75%, Baseline (adaptation disabled)); skin: 63.1043% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.7590% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.7303% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 47.4641% (minimum 75%, Baseline (adaptation disabled)); stomach: 58.4906% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.9460% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.5596% (minimum 65%, Baseline (adaptation disabled)); tongue: 49.3532% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.8286% (minimum 70%, Baseline (adaptation disabled))",-0.0964286,-0.213725,-0.332492,0,2,partial,69.2,52.4,40,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 3); tongue: 50.9 nTPM (protected, limit 3); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 3); bone marrow: 45.7 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 3); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (manageable, limit 5); smooth muscle: 39.4 nTPM (vital, limit 1); thymus: 37.5 nTPM (manageable, limit 5); kidney: 37.1 nTPM (vital, limit 1); stomach: 35.2 nTPM (protected, limit 3); thyroid gland: 35.1 nTPM (manageable, limit 5); small intestine: 33.4 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 3); adrenal gland: 32.6 nTPM (vital, limit 1); rectum: 30.9 nTPM (protected, limit 3); liver: 30.1 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); skin: 29 nTPM (manageable, limit 5); salivary gland: 27.3 nTPM (protected, limit 3); lymph node: 27.1 nTPM (protected, limit 3); lung: 26.7 nTPM (vital, limit 1); duodenum: 25.6 nTPM (vital, limit 1); spleen: 23.6 nTPM (manageable, limit 5); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152102,FAM168B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 81.8182% (minimum 99%, Missing); basal ganglia: 90.0000% (minimum 99%, Missing); bone marrow: 75.0000% (minimum 95%, Enhanced); cerebral cortex: 90.0000% (minimum 95%, Enhanced); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 90.0000% (minimum 99%, Missing); lymph node: 64.2857% (minimum 80%, Enhanced); midbrain: 90.0000% (minimum 99%, Missing); retina: 26.4706% (minimum 99%, Missing); skeletal muscle: 69.2308% (minimum 95%, Enhanced); spinal cord: 64.2857% (minimum 99%, Missing); thymus: 56.2500% (minimum 95%, Missing); tongue: 90.0000% (minimum 97%, Missing)",-0.3875,-0.157143,-0.725294,0,1,partial,2.5,0.5,0.7,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152192,POU4F1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 26.4706% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing); thymus: 56.2500% (minimum 65%, Missing)",-0.0875,0.0928571,-0.485294,0,1,partial,2.5,0.5,0.7,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152192,POU4F1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 26.4706% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing); thymus: 56.2500% (minimum 65%, Missing)",-0.0875,0.0928571,-0.485294,0,1,partial,2.5,0.5,0.7,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152192,POU4F1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 26.4706% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing); thymus: 56.2500% (minimum 65%, Missing)",-0.0875,0.0928571,-0.485294,0,1,partial,2.5,0.5,0.7,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152192,POU4F1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 64.2857% (minimum 70%, Baseline (adaptation disabled)); retina: 26.4706% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 69.2308% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.2857% (minimum 75%, Baseline (adaptation disabled)); thymus: 56.2500% (minimum 65%, Baseline (adaptation disabled))",-0.0875,-0.0571429,-0.485294,0,1,partial,2.5,0.5,0.7,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152192,POU4F1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.7500% (minimum 95%, Enhanced); amygdala: 95.1009% (minimum 99%, Missing); basal ganglia: 90.4110% (minimum 99%, Missing); cerebellum: 74.6606% (minimum 99%, Missing); cerebral cortex: 90.4110% (minimum 95%, Enhanced); hippocampal formation: 95.6522% (minimum 99%, Missing); hypothalamus: 90.9091% (minimum 99%, Missing); midbrain: 94.8276% (minimum 99%, Missing); retina: 87.5332% (minimum 99%, Missing); spinal cord: 95.1009% (minimum 99%, Missing)",0.05,0.0269789,-0.243394,0,5,partial,11.2,0.1,0,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152208,GRID2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 74.6606% (minimum 75%, Missing)",0.35,0.296979,-0.00339367,0,5,partial,11.2,0.1,0,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152208,GRID2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 74.6606% (minimum 75%, Missing)",0.35,0.296979,-0.00339367,0,5,partial,11.2,0.1,0,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152208,GRID2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 74.6606% (minimum 75%, Missing)",0.35,0.296979,-0.00339367,0,5,partial,11.2,0.1,0,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152208,GRID2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 74.6606% (minimum 75%, Baseline (adaptation disabled))",0.35,0.296979,-0.00339367,0,5,partial,11.2,0.1,0,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152208,GRID2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 80.4878% (minimum 95%, Enhanced); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 86.8421% (minimum 99%, Missing); bone marrow: 45.8333% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 95%, Enhanced); choroid plexus: 97.0588% (minimum 99%, Missing); colon: 62.2642% (minimum 97%, Missing); duodenum: 50.7692% (minimum 99%, Missing); esophagus: 43.4211% (minimum 97%, Missing); heart muscle: 91.6667% (minimum 95%, Enhanced); hippocampal formation: 78.5714% (minimum 99%, Missing); hypothalamus: 80.4878% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 80.4878% (minimum 95%, Enhanced); lung: 78.5714% (minimum 95%, Enhanced); lymph node: 45.8333% (minimum 97%, Missing); midbrain: 84.6154% (minimum 99%, Missing); pancreas: 76.7442% (minimum 95%, Enhanced); pituitary gland: 97.0588% (minimum 99%, Missing); rectum: 68.7500% (minimum 97%, Missing); retina: 67.3469% (minimum 99%, Missing); salivary gland: 76.7442% (minimum 80%, Enhanced); skeletal muscle: 86.8421% (minimum 95%, Enhanced); skin: 76.7442% (minimum 95%, Missing); small intestine: 62.2642% (minimum 99%, Missing); smooth muscle: 78.5714% (minimum 95%, Enhanced); spinal cord: 89.1892% (minimum 99%, Missing); spleen: 61.1111% (minimum 95%, Missing); stomach: 67.3469% (minimum 97%, Missing); thymus: 28.2051% (minimum 95%, Missing)",-0.667949,-0.535789,-0.531667,0,2,partial,3.9,4.3,8.4,"thymus: 8.4 nTPM (manageable, limit 5); esophagus: 4.3 nTPM (protected, limit 2); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152253,SPC25,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); bone marrow: 45.8333% (minimum 75%, Missing); colon: 62.2642% (minimum 70%, Missing); duodenum: 50.7692% (minimum 75%, Missing); esophagus: 43.4211% (minimum 70%, Missing); kidney: 75.0000% (minimum 75%, Missing); lymph node: 45.8333% (minimum 70%, Missing); rectum: 68.7500% (minimum 70%, Missing); retina: 67.3469% (minimum 75%, Missing); small intestine: 62.2642% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); stomach: 67.3469% (minimum 70%, Missing); thymus: 28.2051% (minimum 65%, Missing)",-0.367949,-0.265789,-0.291667,0,2,partial,3.9,4.3,8.4,"thymus: 8.4 nTPM (manageable, limit 5); esophagus: 4.3 nTPM (protected, limit 2); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152253,SPC25,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); bone marrow: 45.8333% (minimum 75%, Missing); colon: 62.2642% (minimum 70%, Missing); duodenum: 50.7692% (minimum 75%, Missing); esophagus: 43.4211% (minimum 70%, Missing); kidney: 75.0000% (minimum 75%, Missing); lymph node: 45.8333% (minimum 70%, Missing); rectum: 68.7500% (minimum 70%, Missing); retina: 67.3469% (minimum 75%, Missing); small intestine: 62.2642% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); stomach: 67.3469% (minimum 70%, Missing); thymus: 28.2051% (minimum 65%, Missing)",-0.367949,-0.265789,-0.291667,0,2,partial,3.9,4.3,8.4,"thymus: 8.4 nTPM (manageable, limit 5); esophagus: 4.3 nTPM (protected, limit 3); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152253,SPC25,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); bone marrow: 45.8333% (minimum 75%, Missing); colon: 62.2642% (minimum 70%, Missing); duodenum: 50.7692% (minimum 75%, Missing); esophagus: 43.4211% (minimum 70%, Missing); kidney: 75.0000% (minimum 75%, Missing); lymph node: 45.8333% (minimum 70%, Missing); rectum: 68.7500% (minimum 70%, Missing); retina: 67.3469% (minimum 75%, Missing); small intestine: 62.2642% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); stomach: 67.3469% (minimum 70%, Missing); thymus: 28.2051% (minimum 65%, Missing)",-0.367949,-0.265789,-0.291667,0,2,partial,3.9,4.3,8.4,"thymus: 8.4 nTPM (manageable, limit 5); esophagus: 4.3 nTPM (protected, limit 3); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152253,SPC25,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 45.8333% (minimum 75%, Baseline (adaptation disabled)); colon: 62.2642% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.7692% (minimum 75%, Baseline (adaptation disabled)); esophagus: 43.4211% (minimum 70%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 45.8333% (minimum 70%, Baseline (adaptation disabled)); rectum: 68.7500% (minimum 70%, Baseline (adaptation disabled)); retina: 67.3469% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.2642% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.1111% (minimum 65%, Baseline (adaptation disabled)); stomach: 67.3469% (minimum 70%, Baseline (adaptation disabled)); thymus: 28.2051% (minimum 65%, Baseline (adaptation disabled))",-0.367949,-0.265789,-0.291667,0,2,partial,3.9,4.3,8.4,"thymus: 8.4 nTPM (manageable, limit 5); esophagus: 4.3 nTPM (protected, limit 3); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152253,SPC25,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.8367% (minimum 98%, Approved); amygdala: 89.1089% (minimum 99%, Missing); basal ganglia: 91.8367% (minimum 99%, Missing); cerebral cortex: 87.3786% (minimum 99%, Missing); choroid plexus: 67.6692% (minimum 99%, Missing); duodenum: 95.7447% (minimum 98%, Approved); heart muscle: 84.9057% (minimum 98%, Approved); hippocampal formation: 90.0000% (minimum 99%, Missing); hypothalamus: 88.2353% (minimum 99%, Missing); kidney: 70.3125% (minimum 98%, Approved); liver: 94.7368% (minimum 98%, Approved); lung: 95.7447% (minimum 98%, Approved); lymph node: 93.7500% (minimum 95%, Approved); midbrain: 90.0000% (minimum 99%, Missing); pancreas: 96.7742% (minimum 98%, Approved); parathyroid gland: 60.8108% (minimum 95%, Approved); pituitary gland: 96.7742% (minimum 99%, Missing); rectum: 94.7368% (minimum 95%, Approved); small intestine: 94.7368% (minimum 98%, Approved); smooth muscle: 96.7742% (minimum 98%, Approved); spinal cord: 88.2353% (minimum 99%, Missing); thymus: 90.0000% (minimum 95%, Missing); thyroid gland: 83.3333% (minimum 90%, Approved)",-0.0666667,-0.341892,-0.313308,0,0,routine_complete,4.3,5.8,1.8,"parathyroid gland: 5.8 nTPM (protected, limit 4); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 2); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152315,KCNK13,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 67.6692% (minimum 75%, Missing); parathyroid gland: 60.8108% (minimum 65%, Approved)",0.233333,-0.0418919,-0.0733083,0,0,routine_complete,4.3,5.8,1.8,"parathyroid gland: 5.8 nTPM (protected, limit 4); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 2); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152315,KCNK13,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 67.6692% (minimum 75%, Missing); parathyroid gland: 60.8108% (minimum 65%, Approved)",0.233333,-0.0418919,-0.0733083,0,0,routine_complete,4.3,5.8,1.8,"parathyroid gland: 5.8 nTPM (protected, limit 4); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 2); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152315,KCNK13,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 67.6692% (minimum 75%, Missing); parathyroid gland: 60.8108% (minimum 65%, Approved)",0.233333,-0.0418919,-0.0733083,0,0,routine_complete,4.3,5.8,1.8,"parathyroid gland: 5.8 nTPM (protected, limit 4); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 2); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152315,KCNK13,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 67.6692% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.3125% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.8108% (minimum 70%, Baseline (adaptation disabled))",0.183333,-0.0918919,-0.0733083,0,0,routine_complete,4.3,5.8,1.8,"parathyroid gland: 5.8 nTPM (protected, limit 3); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152315,KCNK13,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.4638% (minimum 95%, Missing); adrenal gland: 66.2252% (minimum 99%, Missing); amygdala: 74.6269% (minimum 99%, Missing); basal ganglia: 75.7576% (minimum 99%, Missing); bone marrow: 65.3595% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 99%, Missing); cerebral cortex: 72.4638% (minimum 99%, Missing); choroid plexus: 62.8931% (minimum 99%, Missing); colon: 65.3595% (minimum 97%, Missing); duodenum: 75.7576% (minimum 99%, Missing); esophagus: 67.5676% (minimum 97%, Missing); heart muscle: 69.4444% (minimum 99%, Missing); hippocampal formation: 75.1880% (minimum 99%, Missing); hypothalamus: 75.7576% (minimum 99%, Missing); kidney: 64.9351% (minimum 99%, Missing); liver: 61.3497% (minimum 99%, Missing); lung: 73.5294% (minimum 99%, Missing); lymph node: 74.6269% (minimum 97%, Missing); midbrain: 71.9424% (minimum 99%, Missing); pancreas: 69.9301% (minimum 99%, Missing); parathyroid gland: 47.1698% (minimum 95%, Approved); pituitary gland: 71.9424% (minimum 99%, Missing); rectum: 62.8931% (minimum 97%, Missing); retina: 74.6269% (minimum 99%, Missing); salivary gland: 73.5294% (minimum 97%, Missing); skeletal muscle: 59.1716% (minimum 99%, Missing); skin: 62.1118% (minimum 95%, Missing); small intestine: 76.3359% (minimum 99%, Missing); smooth muscle: 65.3595% (minimum 99%, Missing); spinal cord: 69.4444% (minimum 99%, Missing); spleen: 72.4638% (minimum 95%, Missing); stomach: 68.9655% (minimum 97%, Missing); thymus: 56.8182% (minimum 95%, Missing); thyroid gland: 59.1716% (minimum 95%, Missing); tongue: 76.9231% (minimum 97%, Missing); urinary bladder: 72.4638% (minimum 97%, Missing)",-0.381818,-0.478302,-0.398284,0,3,partial,6.9,11.2,7.6,"parathyroid gland: 11.2 nTPM (protected, limit 4); thymus: 7.6 nTPM (manageable, limit 5); thyroid gland: 6.9 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); rectum: 5.9 nTPM (protected, limit 2); choroid plexus: 5.9 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); stomach: 4.5 nTPM (protected, limit 2); heart muscle: 4.4 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); salivary gland: 3.6 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); retina: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152348,ATG10,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.2252% (minimum 75%, Missing); amygdala: 74.6269% (minimum 75%, Missing); bone marrow: 65.3595% (minimum 75%, Missing); cerebral cortex: 72.4638% (minimum 75%, Missing); choroid plexus: 62.8931% (minimum 75%, Missing); colon: 65.3595% (minimum 70%, Missing); esophagus: 67.5676% (minimum 70%, Missing); heart muscle: 69.4444% (minimum 75%, Missing); kidney: 64.9351% (minimum 75%, Missing); liver: 61.3497% (minimum 75%, Missing); lung: 73.5294% (minimum 75%, Missing); midbrain: 71.9424% (minimum 75%, Missing); pancreas: 69.9301% (minimum 75%, Missing); parathyroid gland: 47.1698% (minimum 65%, Approved); pituitary gland: 71.9424% (minimum 75%, Missing); rectum: 62.8931% (minimum 70%, Missing); retina: 74.6269% (minimum 75%, Missing); skeletal muscle: 59.1716% (minimum 75%, Missing); skin: 62.1118% (minimum 65%, Missing); smooth muscle: 65.3595% (minimum 75%, Missing); spinal cord: 69.4444% (minimum 75%, Missing); stomach: 68.9655% (minimum 70%, Missing); thymus: 56.8182% (minimum 65%, Missing); thyroid gland: 59.1716% (minimum 65%, Missing)",-0.0818182,-0.178302,-0.158284,0,3,partial,6.9,11.2,7.6,"parathyroid gland: 11.2 nTPM (protected, limit 4); thymus: 7.6 nTPM (manageable, limit 5); thyroid gland: 6.9 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); rectum: 5.9 nTPM (protected, limit 2); choroid plexus: 5.9 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); stomach: 4.5 nTPM (protected, limit 2); heart muscle: 4.4 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); salivary gland: 3.6 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); retina: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152348,ATG10,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.2252% (minimum 75%, Missing); amygdala: 74.6269% (minimum 75%, Missing); bone marrow: 65.3595% (minimum 75%, Missing); cerebral cortex: 72.4638% (minimum 75%, Missing); choroid plexus: 62.8931% (minimum 75%, Missing); colon: 65.3595% (minimum 70%, Missing); esophagus: 67.5676% (minimum 70%, Missing); heart muscle: 69.4444% (minimum 75%, Missing); kidney: 64.9351% (minimum 75%, Missing); liver: 61.3497% (minimum 75%, Missing); lung: 73.5294% (minimum 75%, Missing); midbrain: 71.9424% (minimum 75%, Missing); pancreas: 69.9301% (minimum 75%, Missing); parathyroid gland: 47.1698% (minimum 65%, Approved); pituitary gland: 71.9424% (minimum 75%, Missing); rectum: 62.8931% (minimum 70%, Missing); retina: 74.6269% (minimum 75%, Missing); skeletal muscle: 59.1716% (minimum 75%, Missing); skin: 62.1118% (minimum 65%, Missing); smooth muscle: 65.3595% (minimum 75%, Missing); spinal cord: 69.4444% (minimum 75%, Missing); stomach: 68.9655% (minimum 70%, Missing); thymus: 56.8182% (minimum 65%, Missing); thyroid gland: 59.1716% (minimum 65%, Missing)",-0.0818182,-0.178302,-0.158284,0,3,partial,6.9,11.2,7.6,"parathyroid gland: 11.2 nTPM (protected, limit 4); thymus: 7.6 nTPM (manageable, limit 5); thyroid gland: 6.9 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); rectum: 5.9 nTPM (protected, limit 3); choroid plexus: 5.9 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); stomach: 4.5 nTPM (protected, limit 3); spinal cord: 4.4 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152348,ATG10,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.2252% (minimum 75%, Missing); amygdala: 74.6269% (minimum 75%, Missing); bone marrow: 65.3595% (minimum 75%, Missing); cerebral cortex: 72.4638% (minimum 75%, Missing); choroid plexus: 62.8931% (minimum 75%, Missing); colon: 65.3595% (minimum 70%, Missing); esophagus: 67.5676% (minimum 70%, Missing); heart muscle: 69.4444% (minimum 75%, Missing); kidney: 64.9351% (minimum 75%, Missing); liver: 61.3497% (minimum 75%, Missing); lung: 73.5294% (minimum 75%, Missing); midbrain: 71.9424% (minimum 75%, Missing); pancreas: 69.9301% (minimum 75%, Missing); parathyroid gland: 47.1698% (minimum 65%, Approved); pituitary gland: 71.9424% (minimum 75%, Missing); rectum: 62.8931% (minimum 70%, Missing); retina: 74.6269% (minimum 75%, Missing); skeletal muscle: 59.1716% (minimum 75%, Missing); skin: 62.1118% (minimum 65%, Missing); smooth muscle: 65.3595% (minimum 75%, Missing); spinal cord: 69.4444% (minimum 75%, Missing); stomach: 68.9655% (minimum 70%, Missing); thymus: 56.8182% (minimum 65%, Missing); thyroid gland: 59.1716% (minimum 65%, Missing)",-0.0818182,-0.178302,-0.158284,0,3,partial,6.9,11.2,7.6,"parathyroid gland: 11.2 nTPM (protected, limit 4); thymus: 7.6 nTPM (manageable, limit 5); thyroid gland: 6.9 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); rectum: 5.9 nTPM (protected, limit 3); choroid plexus: 5.9 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); stomach: 4.5 nTPM (protected, limit 3); spinal cord: 4.4 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152348,ATG10,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.2252% (minimum 75%, Baseline (adaptation disabled)); amygdala: 74.6269% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 65.3595% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.4638% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 62.8931% (minimum 75%, Baseline (adaptation disabled)); colon: 65.3595% (minimum 70%, Baseline (adaptation disabled)); esophagus: 67.5676% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.4444% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.9351% (minimum 75%, Baseline (adaptation disabled)); liver: 61.3497% (minimum 75%, Baseline (adaptation disabled)); lung: 73.5294% (minimum 75%, Baseline (adaptation disabled)); midbrain: 71.9424% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.9301% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 47.1698% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.9424% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.8931% (minimum 70%, Baseline (adaptation disabled)); retina: 74.6269% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 59.1716% (minimum 75%, Baseline (adaptation disabled)); skin: 62.1118% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 65.3595% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.4444% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.9655% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.8182% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 59.1716% (minimum 65%, Baseline (adaptation disabled))",-0.0818182,-0.228302,-0.158284,0,3,partial,6.9,11.2,7.6,"parathyroid gland: 11.2 nTPM (protected, limit 3); thymus: 7.6 nTPM (manageable, limit 5); thyroid gland: 6.9 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); rectum: 5.9 nTPM (protected, limit 3); choroid plexus: 5.9 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); stomach: 4.5 nTPM (protected, limit 3); spinal cord: 4.4 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152348,ATG10,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Uncertain); adrenal gland: 72.8814% (minimum 99%, Missing); amygdala: 75.8824% (minimum 99%, Missing); basal ganglia: 71.6667% (minimum 99%, Missing); bone marrow: 55.8442% (minimum 99%, Missing); cerebellum: 62.9268% (minimum 99%, Missing); cerebral cortex: 67.1875% (minimum 99%, Missing); choroid plexus: 80.6250% (minimum 99%, Missing); colon: 55.1282% (minimum 97%, Missing); duodenum: 80.6250% (minimum 99%, Missing); esophagus: 72.8814% (minimum 97%, Missing); heart muscle: 72.8814% (minimum 99%, Missing); hippocampal formation: 75.4386% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 67.5393% (minimum 99%, Missing); liver: 71.6667% (minimum 99%, Missing); lung: 77.2455% (minimum 99%, Missing); lymph node: 75.8824% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 58.6364% (minimum 99%, Missing); parathyroid gland: 53.7500% (minimum 97%, Missing); pituitary gland: 73.2955% (minimum 99%, Missing); rectum: 75.4386% (minimum 97%, Missing); retina: 53.0864% (minimum 99%, Missing); salivary gland: 64.1791% (minimum 97%, Missing); skeletal muscle: 60.0000% (minimum 99%, Missing); skin: 66.4948% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 64.8241% (minimum 99%, Missing); spinal cord: 72.8814% (minimum 99%, Missing); spleen: 72.8814% (minimum 95%, Missing); stomach: 72.0670% (minimum 97%, Missing); thymus: 70.4918% (minimum 95%, Missing); thyroid gland: 56.5789% (minimum 95%, Missing); tongue: 63.5468% (minimum 97%, Missing); urinary bladder: 68.9840% (minimum 97%, Missing)",-0.384211,-0.4325,-0.459136,0,2,partial,11.4,11.1,9.9,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); colon: 10.5 nTPM (protected, limit 2); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); smooth muscle: 7 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); thymus: 5.4 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152409,JMY,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.8814% (minimum 75%, Missing); basal ganglia: 71.6667% (minimum 75%, Missing); bone marrow: 55.8442% (minimum 75%, Missing); cerebellum: 62.9268% (minimum 75%, Missing); cerebral cortex: 67.1875% (minimum 75%, Missing); colon: 55.1282% (minimum 70%, Missing); heart muscle: 72.8814% (minimum 75%, Missing); kidney: 67.5393% (minimum 75%, Missing); liver: 71.6667% (minimum 75%, Missing); pancreas: 58.6364% (minimum 75%, Missing); parathyroid gland: 53.7500% (minimum 70%, Missing); pituitary gland: 73.2955% (minimum 75%, Missing); retina: 53.0864% (minimum 75%, Missing); salivary gland: 64.1791% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); smooth muscle: 64.8241% (minimum 75%, Missing); spinal cord: 72.8814% (minimum 75%, Missing); thyroid gland: 56.5789% (minimum 65%, Missing); tongue: 63.5468% (minimum 70%, Missing); urinary bladder: 68.9840% (minimum 70%, Missing)",-0.0842105,-0.1625,-0.219136,0,2,partial,11.4,11.1,9.9,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); colon: 10.5 nTPM (protected, limit 2); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); smooth muscle: 7 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); thymus: 5.4 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152409,JMY,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.8814% (minimum 75%, Missing); basal ganglia: 71.6667% (minimum 75%, Missing); bone marrow: 55.8442% (minimum 75%, Missing); cerebellum: 62.9268% (minimum 75%, Missing); cerebral cortex: 67.1875% (minimum 75%, Missing); colon: 55.1282% (minimum 70%, Missing); heart muscle: 72.8814% (minimum 75%, Missing); kidney: 67.5393% (minimum 75%, Missing); liver: 71.6667% (minimum 75%, Missing); pancreas: 58.6364% (minimum 75%, Missing); parathyroid gland: 53.7500% (minimum 70%, Missing); pituitary gland: 73.2955% (minimum 75%, Missing); retina: 53.0864% (minimum 75%, Missing); salivary gland: 64.1791% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); smooth muscle: 64.8241% (minimum 75%, Missing); spinal cord: 72.8814% (minimum 75%, Missing); thyroid gland: 56.5789% (minimum 65%, Missing); tongue: 63.5468% (minimum 70%, Missing); urinary bladder: 68.9840% (minimum 70%, Missing)",-0.0842105,-0.1625,-0.219136,0,2,partial,11.4,11.1,9.9,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); colon: 10.5 nTPM (protected, limit 3); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); smooth muscle: 7 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 3); thymus: 5.4 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 3); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 3); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152409,JMY,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.8814% (minimum 75%, Missing); basal ganglia: 71.6667% (minimum 75%, Missing); bone marrow: 55.8442% (minimum 75%, Missing); cerebellum: 62.9268% (minimum 75%, Missing); cerebral cortex: 67.1875% (minimum 75%, Missing); colon: 55.1282% (minimum 70%, Missing); heart muscle: 72.8814% (minimum 75%, Missing); kidney: 67.5393% (minimum 75%, Missing); liver: 71.6667% (minimum 75%, Missing); pancreas: 58.6364% (minimum 75%, Missing); parathyroid gland: 53.7500% (minimum 70%, Missing); pituitary gland: 73.2955% (minimum 75%, Missing); retina: 53.0864% (minimum 75%, Missing); salivary gland: 64.1791% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); smooth muscle: 64.8241% (minimum 75%, Missing); spinal cord: 72.8814% (minimum 75%, Missing); thyroid gland: 56.5789% (minimum 65%, Missing); tongue: 63.5468% (minimum 70%, Missing); urinary bladder: 68.9840% (minimum 70%, Missing)",-0.0842105,-0.1625,-0.219136,0,2,partial,11.4,11.1,9.9,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); colon: 10.5 nTPM (protected, limit 3); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); smooth muscle: 7 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 3); thymus: 5.4 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 3); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 3); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152409,JMY,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.8814% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.6667% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 55.8442% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.9268% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 67.1875% (minimum 75%, Baseline (adaptation disabled)); colon: 55.1282% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 72.8814% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.5393% (minimum 75%, Baseline (adaptation disabled)); liver: 71.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.6364% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 53.7500% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 73.2955% (minimum 75%, Baseline (adaptation disabled)); retina: 53.0864% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.1791% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.8241% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.8814% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 56.5789% (minimum 65%, Baseline (adaptation disabled)); tongue: 63.5468% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 68.9840% (minimum 70%, Baseline (adaptation disabled))",-0.0842105,-0.1625,-0.219136,0,2,partial,11.4,11.1,9.9,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); colon: 10.5 nTPM (protected, limit 3); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); smooth muscle: 7 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 3); thymus: 5.4 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 3); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 3); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152409,JMY,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.4062% (minimum 95%, Missing); adrenal gland: 67.4603% (minimum 99%, Missing); amygdala: 70.2479% (minimum 99%, Missing); basal ganglia: 66.9291% (minimum 99%, Missing); bone marrow: 65.8915% (minimum 99%, Missing); cerebellum: 84.1584% (minimum 99%, Missing); cerebral cortex: 72.0339% (minimum 99%, Missing); choroid plexus: 85.0000% (minimum 99%, Missing); colon: 59.8592% (minimum 97%, Missing); duodenum: 53.7975% (minimum 99%, Missing); esophagus: 69.6721% (minimum 97%, Missing); heart muscle: 52.4691% (minimum 99%, Missing); hippocampal formation: 68.5484% (minimum 99%, Missing); hypothalamus: 73.2759% (minimum 99%, Missing); kidney: 54.8387% (minimum 99%, Missing); liver: 61.5942% (minimum 97%, Supported); lung: 65.3846% (minimum 99%, Missing); lymph node: 50.5952% (minimum 97%, Missing); midbrain: 68.0000% (minimum 99%, Missing); pancreas: 77.9817% (minimum 99%, Missing); parathyroid gland: 77.9817% (minimum 97%, Missing); pituitary gland: 80.1887% (minimum 99%, Missing); rectum: 60.7143% (minimum 97%, Missing); retina: 78.7037% (minimum 99%, Missing); salivary gland: 72.0339% (minimum 97%, Missing); skeletal muscle: 77.2727% (minimum 99%, Missing); skin: 72.6496% (minimum 95%, Missing); small intestine: 62.9630% (minimum 99%, Missing); smooth muscle: 69.6721% (minimum 97%, Supported); spinal cord: 68.0000% (minimum 99%, Missing); spleen: 64.3939% (minimum 95%, Missing); stomach: 66.9291% (minimum 97%, Missing); thymus: 45.9459% (minimum 95%, Missing); thyroid gland: 66.9291% (minimum 95%, Missing); tongue: 78.7037% (minimum 97%, Missing); urinary bladder: 61.5942% (minimum 97%, Missing)",-0.490541,-0.464048,-0.465309,0,6,partial,7.7,8.3,10,"thymus: 10 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 2); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 3); urinary bladder: 5.3 nTPM (protected, limit 2); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); adrenal gland: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 3); esophagus: 3.7 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152422,XRCC4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.4603% (minimum 75%, Missing); amygdala: 70.2479% (minimum 75%, Missing); basal ganglia: 66.9291% (minimum 75%, Missing); bone marrow: 65.8915% (minimum 75%, Missing); cerebral cortex: 72.0339% (minimum 75%, Missing); colon: 59.8592% (minimum 70%, Missing); duodenum: 53.7975% (minimum 75%, Missing); esophagus: 69.6721% (minimum 70%, Missing); heart muscle: 52.4691% (minimum 75%, Missing); hippocampal formation: 68.5484% (minimum 75%, Missing); hypothalamus: 73.2759% (minimum 75%, Missing); kidney: 54.8387% (minimum 75%, Missing); liver: 61.5942% (minimum 65%, Supported); lung: 65.3846% (minimum 75%, Missing); lymph node: 50.5952% (minimum 70%, Missing); midbrain: 68.0000% (minimum 75%, Missing); rectum: 60.7143% (minimum 70%, Missing); small intestine: 62.9630% (minimum 75%, Missing); spinal cord: 68.0000% (minimum 75%, Missing); spleen: 64.3939% (minimum 65%, Missing); stomach: 66.9291% (minimum 70%, Missing); thymus: 45.9459% (minimum 65%, Missing); urinary bladder: 61.5942% (minimum 70%, Missing)",-0.190541,-0.194048,-0.225309,0,6,partial,7.7,8.3,10,"thymus: 10 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 2); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 3); urinary bladder: 5.3 nTPM (protected, limit 2); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); adrenal gland: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 3); esophagus: 3.7 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152422,XRCC4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.4603% (minimum 75%, Missing); amygdala: 70.2479% (minimum 75%, Missing); basal ganglia: 66.9291% (minimum 75%, Missing); bone marrow: 65.8915% (minimum 75%, Missing); cerebral cortex: 72.0339% (minimum 75%, Missing); colon: 59.8592% (minimum 70%, Missing); duodenum: 53.7975% (minimum 75%, Missing); esophagus: 69.6721% (minimum 70%, Missing); heart muscle: 52.4691% (minimum 75%, Missing); hippocampal formation: 68.5484% (minimum 75%, Missing); hypothalamus: 73.2759% (minimum 75%, Missing); kidney: 54.8387% (minimum 75%, Missing); liver: 61.5942% (minimum 65%, Supported); lung: 65.3846% (minimum 75%, Missing); lymph node: 50.5952% (minimum 70%, Missing); midbrain: 68.0000% (minimum 75%, Missing); rectum: 60.7143% (minimum 70%, Missing); small intestine: 62.9630% (minimum 75%, Missing); spinal cord: 68.0000% (minimum 75%, Missing); spleen: 64.3939% (minimum 65%, Missing); stomach: 66.9291% (minimum 70%, Missing); thymus: 45.9459% (minimum 65%, Missing); urinary bladder: 61.5942% (minimum 70%, Missing)",-0.190541,-0.194048,-0.225309,0,6,partial,7.7,8.3,10,"thymus: 10 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 3); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); urinary bladder: 5.3 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 3); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 3); esophagus: 3.7 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152422,XRCC4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.4603% (minimum 75%, Missing); amygdala: 70.2479% (minimum 75%, Missing); basal ganglia: 66.9291% (minimum 75%, Missing); bone marrow: 65.8915% (minimum 75%, Missing); cerebral cortex: 72.0339% (minimum 75%, Missing); colon: 59.8592% (minimum 70%, Missing); duodenum: 53.7975% (minimum 75%, Missing); esophagus: 69.6721% (minimum 70%, Missing); heart muscle: 52.4691% (minimum 75%, Missing); hippocampal formation: 68.5484% (minimum 75%, Missing); hypothalamus: 73.2759% (minimum 75%, Missing); kidney: 54.8387% (minimum 75%, Missing); liver: 61.5942% (minimum 65%, Supported); lung: 65.3846% (minimum 75%, Missing); lymph node: 50.5952% (minimum 70%, Missing); midbrain: 68.0000% (minimum 75%, Missing); rectum: 60.7143% (minimum 70%, Missing); small intestine: 62.9630% (minimum 75%, Missing); spinal cord: 68.0000% (minimum 75%, Missing); spleen: 64.3939% (minimum 65%, Missing); stomach: 66.9291% (minimum 70%, Missing); thymus: 45.9459% (minimum 65%, Missing); urinary bladder: 61.5942% (minimum 70%, Missing)",-0.190541,-0.194048,-0.225309,0,6,partial,7.7,8.3,10,"thymus: 10 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 3); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); urinary bladder: 5.3 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 3); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 3); esophagus: 3.7 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152422,XRCC4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.4603% (minimum 75%, Baseline (adaptation disabled)); amygdala: 70.2479% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.9291% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 65.8915% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.0339% (minimum 75%, Baseline (adaptation disabled)); colon: 59.8592% (minimum 70%, Baseline (adaptation disabled)); duodenum: 53.7975% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.6721% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.4691% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.5484% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.2759% (minimum 75%, Baseline (adaptation disabled)); kidney: 54.8387% (minimum 75%, Baseline (adaptation disabled)); liver: 61.5942% (minimum 75%, Baseline (adaptation disabled)); lung: 65.3846% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.5952% (minimum 70%, Baseline (adaptation disabled)); midbrain: 68.0000% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.7143% (minimum 70%, Baseline (adaptation disabled)); small intestine: 62.9630% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 69.6721% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.3939% (minimum 65%, Baseline (adaptation disabled)); stomach: 66.9291% (minimum 70%, Baseline (adaptation disabled)); thymus: 45.9459% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 61.5942% (minimum 70%, Baseline (adaptation disabled))",-0.190541,-0.194048,-0.225309,0,6,partial,7.7,8.3,10,"thymus: 10 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 3); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); urinary bladder: 5.3 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152422,XRCC4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 92.9550% (minimum 95%, Enhanced)",0.05,0.00336066,-0.0204501,0,1,partial,3.6,1.3,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152430,BOLL,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.273361,0.25,0,1,partial,3.6,1.3,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152430,BOLL,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.273361,0.25,0,1,partial,3.6,1.3,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152430,BOLL,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.273361,0.25,0,1,partial,3.6,1.3,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152430,BOLL,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.273361,0.17955,0,1,partial,3.6,1.3,0,"skeletal muscle: 3.6 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152430,BOLL,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.3992% (minimum 95%, Missing); adrenal gland: 77.0073% (minimum 99%, Missing); amygdala: 79.3233% (minimum 99%, Missing); basal ganglia: 78.1481% (minimum 99%, Missing); bone marrow: 55.5263% (minimum 99%, Missing); cerebellum: 59.7734% (minimum 99%, Missing); cerebral cortex: 77.0073% (minimum 99%, Missing); choroid plexus: 77.8598% (minimum 99%, Missing); colon: 77.2894% (minimum 97%, Missing); duodenum: 77.2894% (minimum 99%, Missing); esophagus: 81.1538% (minimum 97%, Missing); heart muscle: 75.3571% (minimum 99%, Missing); hippocampal formation: 78.7313% (minimum 99%, Missing); hypothalamus: 78.4387% (minimum 99%, Missing); kidney: 74.0351% (minimum 99%, Missing); liver: 76.1733% (minimum 99%, Missing); lung: 77.5735% (minimum 99%, Missing); lymph node: 72.2603% (minimum 97%, Missing); midbrain: 80.5344% (minimum 99%, Missing); pancreas: 82.4219% (minimum 99%, Missing); parathyroid gland: 66.7722% (minimum 97%, Missing); pituitary gland: 72.5086% (minimum 99%, Missing); rectum: 76.4493% (minimum 97%, Missing); retina: 51.3382% (minimum 99%, Missing); salivary gland: 73.5192% (minimum 97%, Missing); skeletal muscle: 70.5686% (minimum 99%, Missing); skin: 77.0073% (minimum 95%, Missing); small intestine: 78.4387% (minimum 99%, Missing); smooth muscle: 84.0637% (minimum 99%, Missing); spinal cord: 78.4387% (minimum 99%, Missing); spleen: 72.7586% (minimum 95%, Missing); stomach: 74.0351% (minimum 97%, Missing); thymus: 63.1737% (minimum 95%, Missing); thyroid gland: 70.0997% (minimum 95%, Missing); tongue: 68.0645% (minimum 97%, Missing); urinary bladder: 79.6226% (minimum 97%, Missing)",-0.318263,-0.302278,-0.476618,0,80,unavailable,20,10.5,12.3,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); thymus: 12.3 nTPM (manageable, limit 5); parathyroid gland: 10.5 nTPM (protected, limit 2); tongue: 9.9 nTPM (protected, limit 2); thyroid gland: 9 nTPM (manageable, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 2); pituitary gland: 8 nTPM (vital, limit 1); spleen: 7.9 nTPM (manageable, limit 5); salivary gland: 7.6 nTPM (protected, limit 2); kidney: 7.4 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 2); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); midbrain: 5.1 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152443,ZNF776,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.5263% (minimum 75%, Missing); cerebellum: 59.7734% (minimum 75%, Missing); kidney: 74.0351% (minimum 75%, Missing); parathyroid gland: 66.7722% (minimum 70%, Missing); pituitary gland: 72.5086% (minimum 75%, Missing); retina: 51.3382% (minimum 75%, Missing); skeletal muscle: 70.5686% (minimum 75%, Missing); thymus: 63.1737% (minimum 65%, Missing); tongue: 68.0645% (minimum 70%, Missing)",-0.0182635,-0.0322785,-0.236618,0,80,unavailable,20,10.5,12.3,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); thymus: 12.3 nTPM (manageable, limit 5); parathyroid gland: 10.5 nTPM (protected, limit 2); tongue: 9.9 nTPM (protected, limit 2); thyroid gland: 9 nTPM (manageable, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 2); pituitary gland: 8 nTPM (vital, limit 1); spleen: 7.9 nTPM (manageable, limit 5); salivary gland: 7.6 nTPM (protected, limit 2); kidney: 7.4 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 2); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); midbrain: 5.1 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152443,ZNF776,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.5263% (minimum 75%, Missing); cerebellum: 59.7734% (minimum 75%, Missing); kidney: 74.0351% (minimum 75%, Missing); parathyroid gland: 66.7722% (minimum 70%, Missing); pituitary gland: 72.5086% (minimum 75%, Missing); retina: 51.3382% (minimum 75%, Missing); skeletal muscle: 70.5686% (minimum 75%, Missing); thymus: 63.1737% (minimum 65%, Missing); tongue: 68.0645% (minimum 70%, Missing)",-0.0182635,-0.0322785,-0.236618,0,80,unavailable,20,10.5,12.3,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); thymus: 12.3 nTPM (manageable, limit 5); parathyroid gland: 10.5 nTPM (protected, limit 3); tongue: 9.9 nTPM (protected, limit 3); thyroid gland: 9 nTPM (manageable, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 3); pituitary gland: 8 nTPM (vital, limit 1); spleen: 7.9 nTPM (manageable, limit 5); salivary gland: 7.6 nTPM (protected, limit 3); kidney: 7.4 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 3); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); midbrain: 5.1 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152443,ZNF776,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.5263% (minimum 75%, Missing); cerebellum: 59.7734% (minimum 75%, Missing); kidney: 74.0351% (minimum 75%, Missing); parathyroid gland: 66.7722% (minimum 70%, Missing); pituitary gland: 72.5086% (minimum 75%, Missing); retina: 51.3382% (minimum 75%, Missing); skeletal muscle: 70.5686% (minimum 75%, Missing); thymus: 63.1737% (minimum 65%, Missing); tongue: 68.0645% (minimum 70%, Missing)",-0.0182635,-0.0322785,-0.236618,0,80,unavailable,20,10.5,12.3,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); thymus: 12.3 nTPM (manageable, limit 5); parathyroid gland: 10.5 nTPM (protected, limit 3); tongue: 9.9 nTPM (protected, limit 3); thyroid gland: 9 nTPM (manageable, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 3); pituitary gland: 8 nTPM (vital, limit 1); spleen: 7.9 nTPM (manageable, limit 5); salivary gland: 7.6 nTPM (protected, limit 3); kidney: 7.4 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 3); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); midbrain: 5.1 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152443,ZNF776,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.5263% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 59.7734% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.0351% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.7722% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.5086% (minimum 75%, Baseline (adaptation disabled)); retina: 51.3382% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 70.5686% (minimum 75%, Baseline (adaptation disabled)); thymus: 63.1737% (minimum 65%, Baseline (adaptation disabled)); tongue: 68.0645% (minimum 70%, Baseline (adaptation disabled))",-0.0182635,-0.0322785,-0.236618,0,80,unavailable,20,10.5,12.3,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); thymus: 12.3 nTPM (manageable, limit 5); parathyroid gland: 10.5 nTPM (protected, limit 3); tongue: 9.9 nTPM (protected, limit 3); thyroid gland: 9 nTPM (manageable, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 3); pituitary gland: 8 nTPM (vital, limit 1); spleen: 7.9 nTPM (manageable, limit 5); salivary gland: 7.6 nTPM (protected, limit 3); kidney: 7.4 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 3); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); midbrain: 5.1 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152443,ZNF776,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.4887% (minimum 99%, Missing); basal ganglia: 95.9698% (minimum 99%, Missing); bone marrow: 88.6047% (minimum 95%, Enhanced); choroid plexus: 98.9610% (minimum 99%, Missing); hippocampal formation: 96.4557% (minimum 99%, Missing); hypothalamus: 96.7005% (minimum 99%, Missing); kidney: 94.0741% (minimum 95%, Enhanced); liver: 92.7007% (minimum 95%, Enhanced); midbrain: 95.7286% (minimum 99%, Missing); pancreas: 94.5409% (minimum 95%, Enhanced); pituitary gland: 96.7005% (minimum 99%, Missing); retina: 92.0290% (minimum 99%, Missing); small intestine: 93.8424% (minimum 95%, Enhanced); smooth muscle: 94.3069% (minimum 95%, Enhanced); spinal cord: 96.2121% (minimum 99%, Missing); thymus: 86.5909% (minimum 95%, Missing); tongue: 96.9466% (minimum 97%, Missing)",-0.0840909,-0.000534351,-0.0697101,0,1,partial,4.9,3.3,5.9,"thymus: 5.9 nTPM (manageable, limit 5); retina: 3.3 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152455,SUV39H2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.215909,0.269466,0.17029,0,1,partial,4.9,3.3,5.9,"thymus: 5.9 nTPM (manageable, limit 5); retina: 3.3 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152455,SUV39H2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.215909,0.269466,0.17029,0,1,partial,4.9,3.3,5.9,"thymus: 5.9 nTPM (manageable, limit 5); retina: 3.3 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152455,SUV39H2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.215909,0.269466,0.17029,0,1,partial,4.9,3.3,5.9,"thymus: 5.9 nTPM (manageable, limit 5); retina: 3.3 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152455,SUV39H2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.215909,0.22029,0.136047,0,1,partial,4.9,3.3,5.9,"thymus: 5.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); liver: 3 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152455,SUV39H2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.6667% (minimum 99%, Missing); amygdala: 98.4906% (minimum 99%, Missing); basal ganglia: 98.1203% (minimum 99%, Missing); choroid plexus: 97.3881% (minimum 99%, Missing); hippocampal formation: 98.4906% (minimum 99%, Missing); hypothalamus: 98.8636% (minimum 99%, Missing); lung: 93.8849% (minimum 95%, Enhanced); midbrain: 98.1203% (minimum 99%, Missing); pituitary gland: 96.3100% (minimum 99%, Missing); retina: 97.3881% (minimum 99%, Missing); salivary gland: 90.9408% (minimum 97%, Missing)",0.0461832,-0.0605923,-0.0269004,0,3,partial,1.7,2.9,8.7,"salivary gland: 2.6 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152463,OLAH,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.25,0.209408,0.2131,0,3,partial,1.7,2.9,8.7,"salivary gland: 2.6 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152463,OLAH,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.25,0.209408,0.2131,0,3,partial,1.7,2.9,8.7,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152463,OLAH,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.25,0.209408,0.2131,0,3,partial,1.7,2.9,8.7,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152463,OLAH,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.1,0.2,0.188849,0,3,partial,1.7,2.9,8.7,"spleen: 8.7 nTPM (manageable, limit 5); lung: 1.7 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152463,OLAH,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.5748% (minimum 90%, Approved); adrenal gland: 78.8851% (minimum 98%, Approved); amygdala: 83.3929% (minimum 99%, Missing); basal ganglia: 80.9359% (minimum 99%, Missing); bone marrow: 79.1525% (minimum 98%, Approved); cerebellum: 68.4751% (minimum 99%, Missing); cerebral cortex: 82.2183% (minimum 99%, Missing); choroid plexus: 73.3124% (minimum 99%, Missing); colon: 74.7200% (minimum 97%, Missing); duodenum: 75.2013% (minimum 99%, Missing); esophagus: 74.7200% (minimum 97%, Missing); heart muscle: 78.7521% (minimum 99%, Missing); hippocampal formation: 82.6549% (minimum 99%, Missing); hypothalamus: 82.0738% (minimum 99%, Missing); kidney: 73.6593% (minimum 99%, Missing); liver: 71.1890% (minimum 98%, Approved); lung: 77.8333% (minimum 99%, Missing); lymph node: 70.4374% (minimum 97%, Missing); midbrain: 82.2183% (minimum 99%, Missing); pancreas: 75.9350% (minimum 98%, Approved); parathyroid gland: 77.1901% (minimum 95%, Approved); pituitary gland: 78.0936% (minimum 99%, Missing); rectum: 74.3631% (minimum 97%, Missing); retina: 78.2245% (minimum 99%, Missing); salivary gland: 76.9357% (minimum 97%, Missing); skeletal muscle: 71.8462% (minimum 98%, Approved); skin: 73.6593% (minimum 95%, Missing); small intestine: 74.3631% (minimum 99%, Missing); smooth muscle: 79.5571% (minimum 98%, Approved); spinal cord: 82.2183% (minimum 99%, Missing); spleen: 73.0829% (minimum 90%, Approved); stomach: 75.6888% (minimum 97%, Missing); thymus: 75.3226% (minimum 95%, Missing); thyroid gland: 74.8397% (minimum 90%, Approved); tongue: 76.5574% (minimum 97%, Missing); urinary bladder: 73.3124% (minimum 97%, Missing)",-0.213407,-0.265626,-0.305249,0,3,partial,21.5,19.6,17.2,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 2); liver: 18.9 nTPM (vital, limit 2); skeletal muscle: 18.3 nTPM (vital, limit 2); spleen: 17.2 nTPM (manageable, limit 10); urinary bladder: 17 nTPM (protected, limit 2); choroid plexus: 17 nTPM (vital, limit 1); kidney: 16.7 nTPM (vital, limit 1); skin: 16.7 nTPM (manageable, limit 5); small intestine: 16.1 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 2); esophagus: 15.8 nTPM (protected, limit 2); colon: 15.8 nTPM (protected, limit 2); thyroid gland: 15.7 nTPM (manageable, limit 10); duodenum: 15.4 nTPM (vital, limit 1); thymus: 15.3 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); pancreas: 14.8 nTPM (vital, limit 2); tongue: 14.3 nTPM (protected, limit 2); salivary gland: 14 nTPM (protected, limit 2); parathyroid gland: 13.8 nTPM (protected, limit 4); adipose tissue: 13.5 nTPM (manageable, limit 10); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); bone marrow: 12.3 nTPM (vital, limit 2); smooth muscle: 12 nTPM (vital, limit 2); basal ganglia: 11 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152464,RPP38,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 68.4751% (minimum 75%, Missing); choroid plexus: 73.3124% (minimum 75%, Missing); kidney: 73.6593% (minimum 75%, Missing); small intestine: 74.3631% (minimum 75%, Missing)",0.0865931,0.00437406,-0.0652493,0,3,partial,21.5,19.6,17.2,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 2); liver: 18.9 nTPM (vital, limit 2); skeletal muscle: 18.3 nTPM (vital, limit 2); spleen: 17.2 nTPM (manageable, limit 10); urinary bladder: 17 nTPM (protected, limit 2); choroid plexus: 17 nTPM (vital, limit 1); kidney: 16.7 nTPM (vital, limit 1); skin: 16.7 nTPM (manageable, limit 5); small intestine: 16.1 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 2); esophagus: 15.8 nTPM (protected, limit 2); colon: 15.8 nTPM (protected, limit 2); thyroid gland: 15.7 nTPM (manageable, limit 10); duodenum: 15.4 nTPM (vital, limit 1); thymus: 15.3 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); pancreas: 14.8 nTPM (vital, limit 2); tongue: 14.3 nTPM (protected, limit 2); salivary gland: 14 nTPM (protected, limit 2); parathyroid gland: 13.8 nTPM (protected, limit 4); adipose tissue: 13.5 nTPM (manageable, limit 10); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); bone marrow: 12.3 nTPM (vital, limit 2); smooth muscle: 12 nTPM (vital, limit 2); basal ganglia: 11 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152464,RPP38,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 68.4751% (minimum 75%, Missing); choroid plexus: 73.3124% (minimum 75%, Missing); kidney: 73.6593% (minimum 75%, Missing); small intestine: 74.3631% (minimum 75%, Missing)",0.0865931,0.00437406,-0.0652493,0,3,partial,21.5,19.6,17.2,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 3); liver: 18.9 nTPM (vital, limit 2); skeletal muscle: 18.3 nTPM (vital, limit 2); spleen: 17.2 nTPM (manageable, limit 10); urinary bladder: 17 nTPM (protected, limit 3); choroid plexus: 17 nTPM (vital, limit 1); kidney: 16.7 nTPM (vital, limit 1); skin: 16.7 nTPM (manageable, limit 5); small intestine: 16.1 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 3); esophagus: 15.8 nTPM (protected, limit 3); colon: 15.8 nTPM (protected, limit 3); thyroid gland: 15.7 nTPM (manageable, limit 10); duodenum: 15.4 nTPM (vital, limit 1); thymus: 15.3 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); pancreas: 14.8 nTPM (vital, limit 2); tongue: 14.3 nTPM (protected, limit 3); salivary gland: 14 nTPM (protected, limit 3); parathyroid gland: 13.8 nTPM (protected, limit 4); adipose tissue: 13.5 nTPM (manageable, limit 10); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); bone marrow: 12.3 nTPM (vital, limit 2); smooth muscle: 12 nTPM (vital, limit 2); basal ganglia: 11 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152464,RPP38,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 68.4751% (minimum 75%, Missing); choroid plexus: 73.3124% (minimum 75%, Missing); kidney: 73.6593% (minimum 75%, Missing); small intestine: 74.3631% (minimum 75%, Missing)",0.0865931,0.00437406,-0.0652493,0,3,partial,21.5,19.6,17.2,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 3); liver: 18.9 nTPM (vital, limit 2); skeletal muscle: 18.3 nTPM (vital, limit 2); spleen: 17.2 nTPM (manageable, limit 10); urinary bladder: 17 nTPM (protected, limit 3); choroid plexus: 17 nTPM (vital, limit 1); kidney: 16.7 nTPM (vital, limit 1); skin: 16.7 nTPM (manageable, limit 5); small intestine: 16.1 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 3); esophagus: 15.8 nTPM (protected, limit 3); colon: 15.8 nTPM (protected, limit 3); thyroid gland: 15.7 nTPM (manageable, limit 10); duodenum: 15.4 nTPM (vital, limit 1); thymus: 15.3 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); pancreas: 14.8 nTPM (vital, limit 2); tongue: 14.3 nTPM (protected, limit 3); salivary gland: 14 nTPM (protected, limit 3); parathyroid gland: 13.8 nTPM (protected, limit 4); adipose tissue: 13.5 nTPM (manageable, limit 10); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); bone marrow: 12.3 nTPM (vital, limit 2); smooth muscle: 12 nTPM (vital, limit 2); basal ganglia: 11 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152464,RPP38,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 68.4751% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.3124% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.6593% (minimum 75%, Baseline (adaptation disabled)); liver: 71.1890% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 71.8462% (minimum 75%, Baseline (adaptation disabled)); small intestine: 74.3631% (minimum 75%, Baseline (adaptation disabled))",0.0808294,0.00437406,-0.0652493,0,3,partial,21.5,19.6,17.2,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 3); liver: 18.9 nTPM (vital, limit 1); skeletal muscle: 18.3 nTPM (vital, limit 1); spleen: 17.2 nTPM (manageable, limit 5); urinary bladder: 17 nTPM (protected, limit 3); choroid plexus: 17 nTPM (vital, limit 1); kidney: 16.7 nTPM (vital, limit 1); skin: 16.7 nTPM (manageable, limit 5); small intestine: 16.1 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 3); esophagus: 15.8 nTPM (protected, limit 3); colon: 15.8 nTPM (protected, limit 3); thyroid gland: 15.7 nTPM (manageable, limit 5); duodenum: 15.4 nTPM (vital, limit 1); thymus: 15.3 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); pancreas: 14.8 nTPM (vital, limit 1); tongue: 14.3 nTPM (protected, limit 3); salivary gland: 14 nTPM (protected, limit 3); parathyroid gland: 13.8 nTPM (protected, limit 3); adipose tissue: 13.5 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); bone marrow: 12.3 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152464,RPP38,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.0937% (minimum 99%, Missing); amygdala: 62.7586% (minimum 99%, Missing); basal ganglia: 34.7328% (minimum 99%, Missing); bone marrow: 74.5902% (minimum 99%, Missing); cerebellum: 14.5367% (minimum 99%, Missing); cerebral cortex: 47.8947% (minimum 99%, Missing); choroid plexus: 97.8495% (minimum 99%, Missing); colon: 87.5000% (minimum 97%, Missing); duodenum: 87.5000% (minimum 99%, Missing); esophagus: 92.8571% (minimum 95%, Approved); hippocampal formation: 64.5390% (minimum 99%, Missing); hypothalamus: 75.2066% (minimum 99%, Missing); kidney: 93.8144% (minimum 99%, Missing); liver: 86.6667% (minimum 99%, Missing); lung: 90.0990% (minimum 99%, Missing); lymph node: 53.5294% (minimum 97%, Missing); midbrain: 86.6667% (minimum 99%, Missing); pancreas: 96.8085% (minimum 98%, Approved); pituitary gland: 93.8144% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 66.4234% (minimum 99%, Missing); small intestine: 79.8246% (minimum 99%, Missing); smooth muscle: 91.9192% (minimum 98%, Approved); spinal cord: 85.0467% (minimum 99%, Missing); spleen: 77.7778% (minimum 90%, Approved); stomach: 85.8491% (minimum 97%, Missing); thymus: 14.4216% (minimum 95%, Missing); urinary bladder: 84.2593% (minimum 97%, Missing)",-0.805784,-0.434706,-0.844633,0,1,partial,53.5,7.9,54,"thymus: 54 nTPM (manageable, limit 5); cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152495,CAMK4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.0937% (minimum 75%, Missing); amygdala: 62.7586% (minimum 75%, Missing); basal ganglia: 34.7328% (minimum 75%, Missing); bone marrow: 74.5902% (minimum 75%, Missing); cerebellum: 14.5367% (minimum 75%, Missing); cerebral cortex: 47.8947% (minimum 75%, Missing); hippocampal formation: 64.5390% (minimum 75%, Missing); lymph node: 53.5294% (minimum 70%, Missing); retina: 66.4234% (minimum 75%, Missing); thymus: 14.4216% (minimum 65%, Missing)",-0.505784,-0.164706,-0.604633,0,1,partial,53.5,7.9,54,"thymus: 54 nTPM (manageable, limit 5); cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152495,CAMK4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.0937% (minimum 75%, Missing); amygdala: 62.7586% (minimum 75%, Missing); basal ganglia: 34.7328% (minimum 75%, Missing); bone marrow: 74.5902% (minimum 75%, Missing); cerebellum: 14.5367% (minimum 75%, Missing); cerebral cortex: 47.8947% (minimum 75%, Missing); hippocampal formation: 64.5390% (minimum 75%, Missing); lymph node: 53.5294% (minimum 70%, Missing); retina: 66.4234% (minimum 75%, Missing); thymus: 14.4216% (minimum 65%, Missing)",-0.505784,-0.164706,-0.604633,0,1,partial,53.5,7.9,54,"thymus: 54 nTPM (manageable, limit 5); cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152495,CAMK4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.0937% (minimum 75%, Missing); amygdala: 62.7586% (minimum 75%, Missing); basal ganglia: 34.7328% (minimum 75%, Missing); bone marrow: 74.5902% (minimum 75%, Missing); cerebellum: 14.5367% (minimum 75%, Missing); cerebral cortex: 47.8947% (minimum 75%, Missing); hippocampal formation: 64.5390% (minimum 75%, Missing); lymph node: 53.5294% (minimum 70%, Missing); retina: 66.4234% (minimum 75%, Missing); thymus: 14.4216% (minimum 65%, Missing)",-0.505784,-0.164706,-0.604633,0,1,partial,53.5,7.9,54,"thymus: 54 nTPM (manageable, limit 5); cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152495,CAMK4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.0937% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.7586% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 34.7328% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 74.5902% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 14.5367% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 47.8947% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.5390% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.5294% (minimum 70%, Baseline (adaptation disabled)); retina: 66.4234% (minimum 75%, Baseline (adaptation disabled)); thymus: 14.4216% (minimum 65%, Baseline (adaptation disabled))",-0.505784,-0.164706,-0.604633,0,1,partial,53.5,7.9,54,"thymus: 54 nTPM (manageable, limit 5); cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152495,CAMK4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 93.9478% (minimum 99%, Missing); basal ganglia: 97.2973% (minimum 99%, Missing); cerebral cortex: 91.4595% (minimum 99%, Missing); choroid plexus: 92.1569% (minimum 99%, Missing); colon: 95.9184% (minimum 97%, Missing); duodenum: 92.5096% (minimum 99%, Missing); hippocampal formation: 92.8650% (minimum 99%, Missing); hypothalamus: 92.8140% (minimum 99%, Missing); midbrain: 93.2745% (minimum 99%, Missing); pituitary gland: 92.8650% (minimum 99%, Missing); rectum: 95.8640% (minimum 97%, Missing); retina: 79.7737% (minimum 99%, Missing); small intestine: 92.6616% (minimum 99%, Missing); spinal cord: 90.9677% (minimum 99%, Missing)",0.0458799,-0.0113598,-0.192263,0,80,unavailable,42.9,7.3,0.7,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152503,TRIM36,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34588,0.25864,0.0477369,0,80,unavailable,42.9,7.3,0.7,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152503,TRIM36,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34588,0.25864,0.0477369,0,80,unavailable,42.9,7.3,0.7,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); basal ganglia: 4.7 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152503,TRIM36,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34588,0.25864,0.0477369,0,80,unavailable,42.9,7.3,0.7,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); basal ganglia: 4.7 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152503,TRIM36,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34588,0.25864,0.0477369,0,80,unavailable,42.9,7.3,0.7,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); basal ganglia: 4.7 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152503,TRIM36,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 80.9524% (minimum 95%, Enhanced); amygdala: 85.9551% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 91.6168% (minimum 95%, Enhanced); cerebellum: 88.4393% (minimum 95%, Enhanced); cerebral cortex: 75.7426% (minimum 95%, Enhanced); choroid plexus: 45.2663% (minimum 99%, Missing); duodenum: 94.4444% (minimum 95%, Enhanced); heart muscle: 89.4737% (minimum 95%, Enhanced); hippocampal formation: 85.0000% (minimum 99%, Missing); hypothalamus: 78.8660% (minimum 99%, Missing); kidney: 67.4009% (minimum 95%, Enhanced); liver: 91.6168% (minimum 95%, Enhanced); lung: 77.6650% (minimum 95%, Enhanced); midbrain: 90.0000% (minimum 99%, Missing); pancreas: 78.0612% (minimum 95%, Enhanced); parathyroid gland: 64.8305% (minimum 80%, Enhanced); pituitary gland: 70.8333% (minimum 99%, Missing); retina: 60.7143% (minimum 99%, Missing); small intestine: 91.0714% (minimum 95%, Enhanced); smooth muscle: 78.8660% (minimum 95%, Enhanced); spinal cord: 90.0000% (minimum 99%, Missing); thymus: 88.4393% (minimum 95%, Missing); tongue: 96.8354% (minimum 97%, Missing)",-0.0656069,-0.151695,-0.537337,0,4,partial,18.5,8.3,8.4,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); kidney: 7.4 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152582,SPEF2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 45.2663% (minimum 75%, Missing); pituitary gland: 70.8333% (minimum 75%, Missing); retina: 60.7143% (minimum 75%, Missing)",0.14557,0.0983051,-0.297337,0,4,partial,18.5,8.3,8.4,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); kidney: 7.4 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152582,SPEF2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 45.2663% (minimum 75%, Missing); pituitary gland: 70.8333% (minimum 75%, Missing); retina: 60.7143% (minimum 75%, Missing)",0.14557,0.0983051,-0.297337,0,4,partial,18.5,8.3,8.4,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); kidney: 7.4 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152582,SPEF2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 45.2663% (minimum 75%, Missing); pituitary gland: 70.8333% (minimum 75%, Missing); retina: 60.7143% (minimum 75%, Missing)",0.14557,0.0983051,-0.297337,0,4,partial,18.5,8.3,8.4,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); kidney: 7.4 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152582,SPEF2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 45.2663% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.4009% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.8305% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.8333% (minimum 75%, Baseline (adaptation disabled)); retina: 60.7143% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 64.5570% (minimum 65%, Baseline (adaptation disabled))",-0.00443038,-0.0516949,-0.297337,0,4,partial,18.5,8.3,8.4,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); thyroid gland: 8.4 nTPM (manageable, limit 5); parathyroid gland: 8.3 nTPM (protected, limit 3); kidney: 7.4 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152582,SPEF2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"urinary bladder: 88.8889% (minimum 97%, Missing)",0.05,-0.0811111,0.01,0,4,partial,0,0.1,0,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152592,DMP1,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.188889,0.25,0,4,partial,0,0.1,0,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152592,DMP1,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.188889,0.25,0,4,partial,0,0.1,0,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152592,DMP1,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.188889,0.25,0,4,partial,0,0.1,0,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152592,DMP1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.188889,0.25,0,4,partial,0,0.1,0,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152592,DMP1,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.0573% (minimum 99%, Missing); basal ganglia: 94.6161% (minimum 99%, Missing); choroid plexus: 54.7777% (minimum 99%, Missing); hippocampal formation: 93.7883% (minimum 99%, Missing); hypothalamus: 93.5428% (minimum 99%, Missing); lung: 93.5428% (minimum 95%, Enhanced); midbrain: 98.5294% (minimum 99%, Missing); pituitary gland: 89.0365% (minimum 99%, Missing); spinal cord: 98.5294% (minimum 99%, Missing); thymus: 94.2832% (minimum 95%, Missing)",-0.00716799,0.03,-0.442223,0,5,partial,88.5,1.1,6.5,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); hippocampal formation: 7.1 nTPM (vital, limit 1); thymus: 6.5 nTPM (manageable, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152611,CAPSL,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 54.7777% (minimum 75%, Missing)",0.292832,0.3,-0.202223,0,5,partial,88.5,1.1,6.5,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); hippocampal formation: 7.1 nTPM (vital, limit 1); thymus: 6.5 nTPM (manageable, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152611,CAPSL,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 54.7777% (minimum 75%, Missing)",0.292832,0.3,-0.202223,0,5,partial,88.5,1.1,6.5,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); hippocampal formation: 7.1 nTPM (vital, limit 1); thymus: 6.5 nTPM (manageable, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152611,CAPSL,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 54.7777% (minimum 75%, Missing)",0.292832,0.3,-0.202223,0,5,partial,88.5,1.1,6.5,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); hippocampal formation: 7.1 nTPM (vital, limit 1); thymus: 6.5 nTPM (manageable, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152611,CAPSL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 54.7777% (minimum 75%, Baseline (adaptation disabled))",0.292832,0.289843,-0.202223,0,5,partial,88.5,1.1,6.5,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); thymus: 6.5 nTPM (manageable, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152611,CAPSL,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.0486245,0.03,0.00793814,0,1,partial,0.4,0.2,0.2,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152670,DDX4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348624,0.3,0.247938,0,1,partial,0.4,0.2,0.2,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152670,DDX4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348624,0.3,0.247938,0,1,partial,0.4,0.2,0.2,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152670,DDX4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348624,0.3,0.247938,0,1,partial,0.4,0.2,0.2,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152670,DDX4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348624,0.298624,0.247253,0,1,partial,0.4,0.2,0.2,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152670,DDX4,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.2973% (minimum 99%, Missing); amygdala: 97.9592% (minimum 99%, Missing); basal ganglia: 97.2973% (minimum 99%, Missing); bone marrow: 97.9592% (minimum 99%, Missing); cerebellum: 98.2935% (minimum 99%, Missing); cerebral cortex: 97.9592% (minimum 99%, Missing); choroid plexus: 95.6811% (minimum 99%, Missing); duodenum: 97.9592% (minimum 99%, Missing); heart muscle: 97.6271% (minimum 99%, Missing); hippocampal formation: 98.2935% (minimum 99%, Missing); hypothalamus: 97.6271% (minimum 99%, Missing); kidney: 94.7368% (minimum 99%, Missing); liver: 94.4262% (minimum 99%, Missing); lung: 98.6301% (minimum 99%, Missing); midbrain: 97.6271% (minimum 99%, Missing); pancreas: 95.6811% (minimum 99%, Missing); pituitary gland: 97.2973% (minimum 99%, Missing); retina: 91.7197% (minimum 99%, Missing); skeletal muscle: 90.8517% (minimum 99%, Missing); small intestine: 97.6271% (minimum 99%, Missing); spinal cord: 97.9592% (minimum 99%, Missing); tongue: 94.4262% (minimum 97%, Missing)",0.0262712,-0.0257377,-0.0814826,0,80,unavailable,2.9,1.7,0.7,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152705,CATSPER3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326271,0.244262,0.158517,0,80,unavailable,2.9,1.7,0.7,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152705,CATSPER3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326271,0.244262,0.158517,0,80,unavailable,2.9,1.7,0.7,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152705,CATSPER3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326271,0.244262,0.158517,0,80,unavailable,2.9,1.7,0.7,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152705,CATSPER3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326271,0.244262,0.158517,0,80,unavailable,2.9,1.7,0.7,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152705,CATSPER3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5307% (minimum 99%, Missing); amygdala: 94.7368% (minimum 99%, Missing); basal ganglia: 92.9348% (minimum 99%, Missing); cerebellum: 98.8439% (minimum 99%, Missing); cerebral cortex: 96.6102% (minimum 99%, Missing); choroid plexus: 63.0996% (minimum 99%, Missing); colon: 86.8020% (minimum 97%, Missing); duodenum: 97.9943% (minimum 99%, Missing); heart muscle: 96.8839% (minimum 99%, Missing); hippocampal formation: 92.9348% (minimum 99%, Missing); hypothalamus: 91.9355% (minimum 99%, Missing); kidney: 84.8635% (minimum 99%, Missing); liver: 96.6102% (minimum 99%, Missing); lung: 89.2950% (minimum 99%, Missing); midbrain: 95.7983% (minimum 99%, Missing); pancreas: 96.0674% (minimum 99%, Missing); parathyroid gland: 83.6186% (minimum 97%, Missing); pituitary gland: 92.6829% (minimum 99%, Missing); rectum: 89.5288% (minimum 97%, Missing); retina: 89.7638% (minimum 99%, Missing); skeletal muscle: 98.5591% (minimum 99%, Missing); small intestine: 98.2759% (minimum 99%, Missing); smooth muscle: 96.3380% (minimum 99%, Missing); spinal cord: 95.5307% (minimum 99%, Missing); thymus: 93.9560% (minimum 95%, Missing); thyroid gland: 85.7143% (minimum 95%, Missing)",-0.0928571,-0.133814,-0.359004,0,80,unavailable,20,6.7,5.7,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 2); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); colon: 5.2 nTPM (protected, limit 2); lung: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152763,DNAI4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.0996% (minimum 75%, Missing)",0.207143,0.136186,-0.119004,0,80,unavailable,20,6.7,5.7,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 2); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); colon: 5.2 nTPM (protected, limit 2); lung: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152763,DNAI4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.0996% (minimum 75%, Missing)",0.207143,0.136186,-0.119004,0,80,unavailable,20,6.7,5.7,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 3); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); colon: 5.2 nTPM (protected, limit 3); lung: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152763,DNAI4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.0996% (minimum 75%, Missing)",0.207143,0.136186,-0.119004,0,80,unavailable,20,6.7,5.7,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 3); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); colon: 5.2 nTPM (protected, limit 3); lung: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152763,DNAI4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.0996% (minimum 75%, Baseline (adaptation disabled))",0.207143,0.136186,-0.119004,0,80,unavailable,20,6.7,5.7,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 3); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); colon: 5.2 nTPM (protected, limit 3); lung: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000152763,DNAI4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.8049% (minimum 90%, Approved); adrenal gland: 93.8111% (minimum 99%, Missing); amygdala: 92.0128% (minimum 99%, Missing); basal ganglia: 91.1392% (minimum 99%, Missing); bone marrow: 46.4516% (minimum 98%, Approved); cerebellum: 94.4262% (minimum 99%, Missing); cerebral cortex: 92.9032% (minimum 99%, Missing); choroid plexus: 97.9592% (minimum 99%, Missing); colon: 80.2228% (minimum 97%, Missing); duodenum: 81.8182% (minimum 99%, Missing); esophagus: 79.7784% (minimum 97%, Missing); heart muscle: 88.3436% (minimum 99%, Missing); hippocampal formation: 92.9032% (minimum 99%, Missing); hypothalamus: 93.5065% (minimum 99%, Missing); kidney: 95.0495% (minimum 99%, Missing); liver: 89.1641% (minimum 99%, Missing); lung: 91.4286% (minimum 99%, Missing); lymph node: 62.4729% (minimum 97%, Missing); midbrain: 92.0128% (minimum 99%, Missing); pancreas: 95.0495% (minimum 99%, Missing); parathyroid gland: 93.8111% (minimum 97%, Missing); pituitary gland: 95.3642% (minimum 99%, Missing); rectum: 78.6885% (minimum 97%, Missing); retina: 92.3077% (minimum 99%, Missing); salivary gland: 91.1392% (minimum 97%, Missing); skeletal muscle: 88.0734% (minimum 99%, Missing); skin: 76.3926% (minimum 95%, Missing); small intestine: 83.4783% (minimum 99%, Missing); smooth muscle: 88.8889% (minimum 99%, Missing); spinal cord: 92.0128% (minimum 99%, Missing); spleen: 85.2071% (minimum 90%, Approved); stomach: 88.8889% (minimum 97%, Missing); thymus: 61.5385% (minimum 95%, Missing); tongue: 88.3436% (minimum 97%, Missing); urinary bladder: 88.6154% (minimum 97%, Missing)",-0.334615,-0.345271,-0.515484,0,6,partial,33.2,17.3,18,"bone marrow: 33.2 nTPM (vital, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 17.3 nTPM (protected, limit 2); skin: 8.9 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 2); esophagus: 7.3 nTPM (protected, limit 2); colon: 7.1 nTPM (protected, limit 2); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); heart muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153044,CENPH,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.4516% (minimum 70%, Approved); lymph node: 62.4729% (minimum 70%, Missing); thymus: 61.5385% (minimum 65%, Missing)",-0.0346154,-0.0752711,-0.235484,0,6,partial,33.2,17.3,18,"bone marrow: 33.2 nTPM (vital, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 17.3 nTPM (protected, limit 2); skin: 8.9 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 2); esophagus: 7.3 nTPM (protected, limit 2); colon: 7.1 nTPM (protected, limit 2); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); heart muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153044,CENPH,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.4516% (minimum 70%, Approved); lymph node: 62.4729% (minimum 70%, Missing); thymus: 61.5385% (minimum 65%, Missing)",-0.0346154,-0.0752711,-0.235484,0,6,partial,33.2,17.3,18,"bone marrow: 33.2 nTPM (vital, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 17.3 nTPM (protected, limit 3); skin: 8.9 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 3); esophagus: 7.3 nTPM (protected, limit 3); colon: 7.1 nTPM (protected, limit 3); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); heart muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153044,CENPH,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.4516% (minimum 70%, Approved); lymph node: 62.4729% (minimum 70%, Missing); thymus: 61.5385% (minimum 65%, Missing)",-0.0346154,-0.0752711,-0.235484,0,6,partial,33.2,17.3,18,"bone marrow: 33.2 nTPM (vital, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 17.3 nTPM (protected, limit 3); skin: 8.9 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 3); esophagus: 7.3 nTPM (protected, limit 3); colon: 7.1 nTPM (protected, limit 3); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); heart muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153044,CENPH,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.4516% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.4729% (minimum 70%, Baseline (adaptation disabled)); thymus: 61.5385% (minimum 65%, Baseline (adaptation disabled))",-0.0346154,-0.0752711,-0.285484,0,6,partial,33.2,17.3,18,"bone marrow: 33.2 nTPM (vital, limit 1); thymus: 18 nTPM (manageable, limit 5); lymph node: 17.3 nTPM (protected, limit 3); skin: 8.9 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 3); esophagus: 7.3 nTPM (protected, limit 3); colon: 7.1 nTPM (protected, limit 3); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); heart muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153044,CENPH,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.7342% (minimum 99%, Missing); hippocampal formation: 98.7342% (minimum 99%, Missing); liver: 97.5000% (minimum 99%, Missing)",0.0468051,0.00196262,-0.015,0,80,unavailable,0.8,0.9,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153060,TEKT5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346805,0.271963,0.225,0,80,unavailable,0.8,0.9,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153060,TEKT5,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346805,0.271963,0.225,0,80,unavailable,0.8,0.9,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153060,TEKT5,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346805,0.271963,0.225,0,80,unavailable,0.8,0.9,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153060,TEKT5,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346805,0.271963,0.225,0,80,unavailable,0.8,0.9,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153060,TEKT5,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.2222% (minimum 99%, Missing); basal ganglia: 98.5915% (minimum 99%, Missing); bone marrow: 85.3659% (minimum 99%, Missing); cerebral cortex: 95.8904% (minimum 99%, Missing); colon: 94.5946% (minimum 97%, Missing); duodenum: 97.2222% (minimum 99%, Missing); esophagus: 94.5946% (minimum 97%, Missing); heart muscle: 94.5946% (minimum 99%, Missing); kidney: 95.8904% (minimum 99%, Missing); lung: 44.0252% (minimum 99%, Missing); lymph node: 90.9091% (minimum 97%, Missing); pancreas: 92.1053% (minimum 99%, Missing); parathyroid gland: 72.1649% (minimum 97%, Missing); pituitary gland: 97.2222% (minimum 99%, Missing); rectum: 95.8904% (minimum 97%, Missing); retina: 93.3333% (minimum 99%, Missing); salivary gland: 94.5946% (minimum 97%, Missing); skeletal muscle: 97.2222% (minimum 99%, Missing); skin: 94.5946% (minimum 95%, Missing); small intestine: 97.2222% (minimum 99%, Missing); spleen: 92.1053% (minimum 95%, Missing); stomach: 95.8904% (minimum 97%, Missing); thyroid gland: 92.1053% (minimum 95%, Missing); urinary bladder: 60.8696% (minimum 97%, Missing)",-0.0289474,-0.361304,-0.549748,0,80,unavailable,8.9,4.5,0.6,"lung: 8.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); parathyroid gland: 2.7 nTPM (protected, limit 2); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153093,ACOXL,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 44.0252% (minimum 75%, Missing); urinary bladder: 60.8696% (minimum 70%, Missing)",0.271053,-0.0913043,-0.309748,0,80,unavailable,8.9,4.5,0.6,"lung: 8.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); parathyroid gland: 2.7 nTPM (protected, limit 2); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153093,ACOXL,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 44.0252% (minimum 75%, Missing); urinary bladder: 60.8696% (minimum 70%, Missing)",0.271053,-0.0913043,-0.309748,0,80,unavailable,8.9,4.5,0.6,"lung: 8.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153093,ACOXL,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 44.0252% (minimum 75%, Missing); urinary bladder: 60.8696% (minimum 70%, Missing)",0.271053,-0.0913043,-0.309748,0,80,unavailable,8.9,4.5,0.6,"lung: 8.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153093,ACOXL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 44.0252% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 60.8696% (minimum 70%, Baseline (adaptation disabled))",0.271053,-0.0913043,-0.309748,0,80,unavailable,8.9,4.5,0.6,"lung: 8.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153093,ACOXL,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.5159% (minimum 95%, Enhanced); amygdala: 98.9238% (minimum 99%, Missing); basal ganglia: 98.3943% (minimum 99%, Missing); cerebellum: 93.3164% (minimum 95%, Enhanced); choroid plexus: 93.3164% (minimum 99%, Missing); heart muscle: 65.7722% (minimum 95%, Enhanced); hippocampal formation: 98.9238% (minimum 99%, Missing); hypothalamus: 95.8297% (minimum 99%, Missing); midbrain: 98.2191% (minimum 99%, Missing); pituitary gland: 91.0066% (minimum 99%, Missing); retina: 86.8504% (minimum 99%, Missing); spinal cord: 98.9238% (minimum 99%, Missing)",0.0287045,0.0165832,-0.292278,0,1,partial,57.4,2.5,2.6,"heart muscle: 57.4 nTPM (vital, limit 6); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 6); choroid plexus: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153132,CLGN,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328705,0.286583,0.0577221,0,1,partial,57.4,2.5,2.6,"heart muscle: 57.4 nTPM (vital, limit 6); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 6); choroid plexus: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153132,CLGN,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328705,0.286583,0.0577221,0,1,partial,57.4,2.5,2.6,"heart muscle: 57.4 nTPM (vital, limit 6); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 6); choroid plexus: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153132,CLGN,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328705,0.286583,0.0577221,0,1,partial,57.4,2.5,2.6,"heart muscle: 57.4 nTPM (vital, limit 6); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 6); choroid plexus: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153132,CLGN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 65.7722% (minimum 75%, Baseline (adaptation disabled))",0.326971,0.277837,-0.0922779,0,1,partial,57.4,2.5,2.6,"heart muscle: 57.4 nTPM (vital, limit 1); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153132,CLGN,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.7838% (minimum 95%, Missing); adrenal gland: 91.1765% (minimum 99%, Missing); amygdala: 86.1111% (minimum 99%, Missing); basal ganglia: 86.1111% (minimum 99%, Missing); bone marrow: 81.5789% (minimum 99%, Missing); cerebellum: 72.0930% (minimum 99%, Missing); cerebral cortex: 81.5789% (minimum 99%, Missing); choroid plexus: 91.1765% (minimum 99%, Missing); colon: 91.1765% (minimum 97%, Missing); duodenum: 96.8750% (minimum 99%, Missing); esophagus: 93.9394% (minimum 97%, Missing); heart muscle: 72.0930% (minimum 99%, Missing); hippocampal formation: 86.1111% (minimum 99%, Missing); hypothalamus: 88.5714% (minimum 99%, Missing); kidney: 73.8095% (minimum 99%, Missing); liver: 96.8750% (minimum 99%, Missing); lung: 64.5833% (minimum 99%, Missing); lymph node: 88.5714% (minimum 97%, Missing); midbrain: 86.1111% (minimum 99%, Missing); pancreas: 65.9574% (minimum 99%, Missing); parathyroid gland: 4.4604% (minimum 97%, Missing); pituitary gland: 91.1765% (minimum 99%, Missing); rectum: 93.9394% (minimum 97%, Missing); retina: 81.5789% (minimum 99%, Missing); salivary gland: 91.1765% (minimum 97%, Missing); skeletal muscle: 93.9394% (minimum 99%, Missing); skin: 88.5714% (minimum 95%, Missing); small intestine: 91.1765% (minimum 99%, Missing); smooth muscle: 93.9394% (minimum 99%, Missing); spinal cord: 86.1111% (minimum 99%, Missing); spleen: 86.1111% (minimum 95%, Missing); stomach: 91.1765% (minimum 97%, Missing); thyroid gland: 73.8095% (minimum 95%, Missing); tongue: 77.5000% (minimum 97%, Missing); urinary bladder: 91.1765% (minimum 97%, Missing)",-0.211905,-0.925396,-0.344167,0,80,unavailable,1.7,66.4,1.1,"parathyroid gland: 66.4 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153157,SYCP2L,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 72.0930% (minimum 75%, Missing); heart muscle: 72.0930% (minimum 75%, Missing); kidney: 73.8095% (minimum 75%, Missing); lung: 64.5833% (minimum 75%, Missing); pancreas: 65.9574% (minimum 75%, Missing); parathyroid gland: 4.4604% (minimum 70%, Missing)",0.0880952,-0.655396,-0.104167,0,80,unavailable,1.7,66.4,1.1,"parathyroid gland: 66.4 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153157,SYCP2L,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 72.0930% (minimum 75%, Missing); heart muscle: 72.0930% (minimum 75%, Missing); kidney: 73.8095% (minimum 75%, Missing); lung: 64.5833% (minimum 75%, Missing); pancreas: 65.9574% (minimum 75%, Missing); parathyroid gland: 4.4604% (minimum 70%, Missing)",0.0880952,-0.655396,-0.104167,0,80,unavailable,1.7,66.4,1.1,"parathyroid gland: 66.4 nTPM (protected, limit 3); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153157,SYCP2L,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 72.0930% (minimum 75%, Missing); heart muscle: 72.0930% (minimum 75%, Missing); kidney: 73.8095% (minimum 75%, Missing); lung: 64.5833% (minimum 75%, Missing); pancreas: 65.9574% (minimum 75%, Missing); parathyroid gland: 4.4604% (minimum 70%, Missing)",0.0880952,-0.655396,-0.104167,0,80,unavailable,1.7,66.4,1.1,"parathyroid gland: 66.4 nTPM (protected, limit 3); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153157,SYCP2L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 72.0930% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 72.0930% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.8095% (minimum 75%, Baseline (adaptation disabled)); lung: 64.5833% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.9574% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 4.4604% (minimum 70%, Baseline (adaptation disabled))",0.0880952,-0.655396,-0.104167,0,80,unavailable,1.7,66.4,1.1,"parathyroid gland: 66.4 nTPM (protected, limit 3); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153157,SYCP2L,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.5294% (minimum 99%, Missing); amygdala: 95.7143% (minimum 99%, Missing); basal ganglia: 95.7143% (minimum 99%, Missing); bone marrow: 95.7143% (minimum 99%, Missing); cerebellum: 97.1014% (minimum 99%, Missing); cerebral cortex: 94.3662% (minimum 99%, Missing); choroid plexus: 97.1014% (minimum 99%, Missing); duodenum: 98.5294% (minimum 99%, Missing); heart muscle: 98.5294% (minimum 99%, Missing); hippocampal formation: 95.7143% (minimum 99%, Missing); hypothalamus: 95.7143% (minimum 99%, Missing); kidney: 90.5405% (minimum 99%, Missing); liver: 90.5405% (minimum 99%, Missing); lung: 97.1014% (minimum 99%, Missing); midbrain: 93.0556% (minimum 99%, Missing); pancreas: 97.1014% (minimum 99%, Missing); pituitary gland: 93.0556% (minimum 99%, Missing); retina: 88.1579% (minimum 99%, Missing); skeletal muscle: 98.5294% (minimum 99%, Missing); small intestine: 98.5294% (minimum 99%, Missing); smooth muscle: 98.5294% (minimum 99%, Missing); spinal cord: 95.7143% (minimum 99%, Missing); spleen: 93.0556% (minimum 95%, Missing); thymus: 77.9070% (minimum 95%, Missing); urinary bladder: 95.7143% (minimum 97%, Missing)",-0.17093,-0.0128571,-0.108421,0,80,unavailable,0.9,0.3,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153165,RGPD3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.12907,0.257143,0.131579,0,80,unavailable,0.9,0.3,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153165,RGPD3,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.12907,0.257143,0.131579,0,80,unavailable,0.9,0.3,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153165,RGPD3,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.12907,0.257143,0.131579,0,80,unavailable,0.9,0.3,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153165,RGPD3,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.12907,0.257143,0.131579,0,80,unavailable,0.9,0.3,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153165,RGPD3,current_fixed,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.0824% (minimum 95%, Missing); adrenal gland: 81.3953% (minimum 99%, Missing); amygdala: 90.7781% (minimum 99%, Missing); basal ganglia: 89.2351% (minimum 99%, Missing); bone marrow: 65.3527% (minimum 99%, Missing); cerebellum: 79.3451% (minimum 99%, Missing); cerebral cortex: 82.6772% (minimum 99%, Missing); choroid plexus: 86.5385% (minimum 99%, Missing); colon: 78.1638% (minimum 97%, Missing); duodenum: 83.1135% (minimum 99%, Missing); esophagus: 77.9703% (minimum 97%, Missing); heart muscle: 83.1135% (minimum 99%, Missing); hippocampal formation: 90.7781% (minimum 99%, Missing); hypothalamus: 90.5172% (minimum 99%, Missing); kidney: 77.0171% (minimum 99%, Missing); liver: 74.8219% (minimum 99%, Missing); lung: 82.0312% (minimum 99%, Missing); lymph node: 77.9703% (minimum 97%, Missing); midbrain: 91.0405% (minimum 99%, Missing); pancreas: 76.6423% (minimum 99%, Missing); parathyroid gland: 71.2670% (minimum 97%, Missing); pituitary gland: 83.5544% (minimum 99%, Missing); rectum: 82.4607% (minimum 97%, Missing); retina: 80.1527% (minimum 99%, Missing); salivary gland: 82.6772% (minimum 97%, Missing); skeletal muscle: 74.8219% (minimum 99%, Missing); skin: 80.1527% (minimum 95%, Missing); small intestine: 83.1135% (minimum 99%, Missing); smooth muscle: 80.5627% (minimum 99%, Missing); spinal cord: 90.7781% (minimum 99%, Missing); spleen: 77.7778% (minimum 95%, Missing); stomach: 79.1457% (minimum 97%, Missing); thymus: 72.5806% (minimum 95%, Missing); thyroid gland: 70.3125% (minimum 95%, Missing); tongue: 67.5966% (minimum 97%, Missing); urinary bladder: 76.0870% (minimum 97%, Missing)",-0.246875,-0.294034,-0.336473,0,2,partial,16.7,15.1,13.3,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 2); thyroid gland: 13.3 nTPM (manageable, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 2); adipose tissue: 12.2 nTPM (manageable, limit 5); thymus: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); skeletal muscle: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 2); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); lymph node: 8.9 nTPM (protected, limit 2); esophagus: 8.9 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); stomach: 8.3 nTPM (protected, limit 2); cerebellum: 8.2 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153207,AHCTF1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 65.3527% (minimum 75%, Missing); liver: 74.8219% (minimum 75%, Missing); skeletal muscle: 74.8219% (minimum 75%, Missing); tongue: 67.5966% (minimum 70%, Missing)",0.053125,-0.0240343,-0.096473,0,2,partial,16.7,15.1,13.3,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 2); thyroid gland: 13.3 nTPM (manageable, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 2); adipose tissue: 12.2 nTPM (manageable, limit 5); thymus: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); skeletal muscle: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 2); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); lymph node: 8.9 nTPM (protected, limit 2); esophagus: 8.9 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); stomach: 8.3 nTPM (protected, limit 2); cerebellum: 8.2 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153207,AHCTF1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 65.3527% (minimum 75%, Missing); liver: 74.8219% (minimum 75%, Missing); skeletal muscle: 74.8219% (minimum 75%, Missing); tongue: 67.5966% (minimum 70%, Missing)",0.053125,-0.0240343,-0.096473,0,2,partial,16.7,15.1,13.3,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 3); thyroid gland: 13.3 nTPM (manageable, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 3); adipose tissue: 12.2 nTPM (manageable, limit 5); thymus: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); skeletal muscle: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 3); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); lymph node: 8.9 nTPM (protected, limit 3); esophagus: 8.9 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); stomach: 8.3 nTPM (protected, limit 3); cerebellum: 8.2 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.6 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153207,AHCTF1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 65.3527% (minimum 75%, Missing); liver: 74.8219% (minimum 75%, Missing); skeletal muscle: 74.8219% (minimum 75%, Missing); tongue: 67.5966% (minimum 70%, Missing)",0.053125,-0.0240343,-0.096473,0,2,partial,16.7,15.1,13.3,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 3); thyroid gland: 13.3 nTPM (manageable, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 3); adipose tissue: 12.2 nTPM (manageable, limit 5); thymus: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); skeletal muscle: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 3); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); lymph node: 8.9 nTPM (protected, limit 3); esophagus: 8.9 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); stomach: 8.3 nTPM (protected, limit 3); cerebellum: 8.2 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.6 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153207,AHCTF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 65.3527% (minimum 75%, Baseline (adaptation disabled)); liver: 74.8219% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 74.8219% (minimum 75%, Baseline (adaptation disabled)); tongue: 67.5966% (minimum 70%, Baseline (adaptation disabled))",0.053125,-0.0240343,-0.096473,0,2,partial,16.7,15.1,13.3,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 3); thyroid gland: 13.3 nTPM (manageable, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 3); adipose tissue: 12.2 nTPM (manageable, limit 5); thymus: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); skeletal muscle: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 3); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); lymph node: 8.9 nTPM (protected, limit 3); esophagus: 8.9 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); stomach: 8.3 nTPM (protected, limit 3); cerebellum: 8.2 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.6 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153207,AHCTF1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.1176% (minimum 99%, Missing); amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 92.3077% (minimum 99%, Missing); cerebellum: 84.2105% (minimum 99%, Missing); cerebral cortex: 94.1176% (minimum 99%, Missing); choroid plexus: 62.3377% (minimum 99%, Missing); heart muscle: 97.9592% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); kidney: 61.5385% (minimum 99%, Missing); liver: 96.0000% (minimum 99%, Missing); lung: 92.3077% (minimum 99%, Missing); midbrain: 92.3077% (minimum 99%, Missing); pancreas: 96.0000% (minimum 99%, Missing); parathyroid gland: 60.7595% (minimum 97%, Missing); pituitary gland: 82.7586% (minimum 99%, Missing); retina: 65.7534% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); smooth muscle: 97.9592% (minimum 99%, Missing); spinal cord: 90.5660% (minimum 99%, Missing); thyroid gland: 80.0000% (minimum 95%, Missing)",-0.15,-0.362405,-0.374615,0,80,unavailable,3,3.1,1.2,"parathyroid gland: 3.1 nTPM (protected, limit 2); kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153237,CCDC148,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 62.3377% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); parathyroid gland: 60.7595% (minimum 70%, Missing); retina: 65.7534% (minimum 75%, Missing)",0.15,-0.0924051,-0.134615,0,80,unavailable,3,3.1,1.2,"parathyroid gland: 3.1 nTPM (protected, limit 2); kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153237,CCDC148,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 62.3377% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); parathyroid gland: 60.7595% (minimum 70%, Missing); retina: 65.7534% (minimum 75%, Missing)",0.15,-0.0924051,-0.134615,0,80,unavailable,3,3.1,1.2,"parathyroid gland: 3.1 nTPM (protected, limit 3); kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153237,CCDC148,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 62.3377% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); parathyroid gland: 60.7595% (minimum 70%, Missing); retina: 65.7534% (minimum 75%, Missing)",0.15,-0.0924051,-0.134615,0,80,unavailable,3,3.1,1.2,"parathyroid gland: 3.1 nTPM (protected, limit 3); kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153237,CCDC148,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 62.3377% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.5385% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.7595% (minimum 70%, Baseline (adaptation disabled)); retina: 65.7534% (minimum 75%, Baseline (adaptation disabled))",0.15,-0.0924051,-0.134615,0,80,unavailable,3,3.1,1.2,"parathyroid gland: 3.1 nTPM (protected, limit 3); kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153237,CCDC148,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.2040% (minimum 99%, Missing); basal ganglia: 95.0762% (minimum 99%, Missing); choroid plexus: 57.2336% (minimum 99%, Missing); heart muscle: 91.7421% (minimum 98%, Approved); hippocampal formation: 94.0835% (minimum 99%, Missing); hypothalamus: 92.3690% (minimum 99%, Missing); lung: 95.0762% (minimum 98%, Approved); midbrain: 97.8287% (minimum 99%, Missing); pituitary gland: 95.7497% (minimum 99%, Missing); spinal cord: 97.8287% (minimum 99%, Missing)",0.05,0.0212575,-0.417664,0,2,partial,60.6,2.4,1.6,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153347,FAM81B,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 57.2336% (minimum 75%, Missing)",0.35,0.3,-0.177664,0,2,partial,60.6,2.4,1.6,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153347,FAM81B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 57.2336% (minimum 75%, Missing)",0.35,0.3,-0.177664,0,2,partial,60.6,2.4,1.6,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153347,FAM81B,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 57.2336% (minimum 75%, Missing)",0.35,0.3,-0.177664,0,2,partial,60.6,2.4,1.6,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153347,FAM81B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 57.2336% (minimum 75%, Baseline (adaptation disabled))",0.330653,0.271257,-0.177664,0,2,partial,60.6,2.4,1.6,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153347,FAM81B,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 89.5204% (minimum 99%, Missing); basal ganglia: 92.9889% (minimum 99%, Missing); cerebellum: 97.8641% (minimum 99%, Missing); cerebral cortex: 80.7692% (minimum 99%, Missing); choroid plexus: 98.0545% (minimum 99%, Missing); hippocampal formation: 96.1832% (minimum 99%, Missing); hypothalamus: 97.8641% (minimum 99%, Missing); kidney: 98.6301% (minimum 99%, Missing); liver: 98.2456% (minimum 99%, Missing); midbrain: 98.0545% (minimum 99%, Missing); pancreas: 98.8235% (minimum 99%, Missing); pituitary gland: 97.1098% (minimum 99%, Missing); spinal cord: 98.6301% (minimum 99%, Missing)",0.0363014,0.0201768,-0.182308,0,80,unavailable,12,0.5,0.7,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153495,TEX29,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336301,0.290177,0.0576923,0,80,unavailable,12,0.5,0.7,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153495,TEX29,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336301,0.290177,0.0576923,0,80,unavailable,12,0.5,0.7,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153495,TEX29,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336301,0.290177,0.0576923,0,80,unavailable,12,0.5,0.7,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153495,TEX29,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336301,0.290177,0.0576923,0,80,unavailable,12,0.5,0.7,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153495,TEX29,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.00634146,0,3,partial,0.5,0.3,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153498,SPACA7,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246341,0,3,partial,0.5,0.3,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153498,SPACA7,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246341,0,3,partial,0.5,0.3,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153498,SPACA7,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246341,0,3,partial,0.5,0.3,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153498,SPACA7,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347558,0.296341,0.243917,0,3,partial,0.5,0.3,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153498,SPACA7,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.00186992,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000153684,GOLGA8F,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.24187,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000153684,GOLGA8F,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.24187,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000153684,GOLGA8F,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.24187,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000153684,GOLGA8F,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.24187,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000153684,GOLGA8F,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.2727% (minimum 90%, Approved); adrenal gland: 87.0588% (minimum 99%, Missing); amygdala: 78.7234% (minimum 99%, Missing); basal ganglia: 79.5699% (minimum 99%, Missing); bone marrow: 90.2439% (minimum 99%, Missing); cerebellum: 92.5000% (minimum 99%, Missing); cerebral cortex: 86.0465% (minimum 99%, Missing); choroid plexus: 52.4823% (minimum 99%, Missing); colon: 54.0146% (minimum 97%, Missing); duodenum: 56.9231% (minimum 99%, Missing); esophagus: 36.6337% (minimum 97%, Missing); heart muscle: 54.8148% (minimum 99%, Missing); hippocampal formation: 75.5102% (minimum 99%, Missing); hypothalamus: 83.1461% (minimum 99%, Missing); kidney: 50.3401% (minimum 99%, Missing); liver: 44.3114% (minimum 99%, Missing); lung: 67.2727% (minimum 99%, Missing); lymph node: 84.0909% (minimum 97%, Missing); midbrain: 76.2887% (minimum 99%, Missing); pancreas: 28.7938% (minimum 99%, Missing); parathyroid gland: 91.3580% (minimum 97%, Missing); pituitary gland: 77.0833% (minimum 99%, Missing); rectum: 69.1589% (minimum 97%, Missing); retina: 74.7475% (minimum 99%, Missing); salivary gland: 57.3643% (minimum 95%, Approved); skeletal muscle: 87.0588% (minimum 99%, Missing); skin: 66.0714% (minimum 95%, Missing); small intestine: 54.4118% (minimum 99%, Missing); smooth muscle: 54.0146% (minimum 98%, Approved); spinal cord: 65.4867% (minimum 99%, Missing); spleen: 62.7119% (minimum 95%, Missing); stomach: 65.4867% (minimum 97%, Missing); thymus: 77.8947% (minimum 95%, Missing); thyroid gland: 78.7234% (minimum 95%, Missing); tongue: 84.0909% (minimum 97%, Missing); urinary bladder: 63.7931% (minimum 97%, Missing)",-0.322881,-0.603663,-0.702062,0,1,partial,18.3,12.8,4.4,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 2); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); smooth muscle: 6.3 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 4); urinary bladder: 4.2 nTPM (protected, limit 2); stomach: 3.9 nTPM (protected, limit 2); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153721,CNKSR3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 52.4823% (minimum 75%, Missing); colon: 54.0146% (minimum 70%, Missing); duodenum: 56.9231% (minimum 75%, Missing); esophagus: 36.6337% (minimum 70%, Missing); heart muscle: 54.8148% (minimum 75%, Missing); kidney: 50.3401% (minimum 75%, Missing); liver: 44.3114% (minimum 75%, Missing); lung: 67.2727% (minimum 75%, Missing); pancreas: 28.7938% (minimum 75%, Missing); rectum: 69.1589% (minimum 70%, Missing); retina: 74.7475% (minimum 75%, Missing); salivary gland: 57.3643% (minimum 65%, Approved); small intestine: 54.4118% (minimum 75%, Missing); smooth muscle: 54.0146% (minimum 70%, Approved); spinal cord: 65.4867% (minimum 75%, Missing); spleen: 62.7119% (minimum 65%, Missing); stomach: 65.4867% (minimum 70%, Missing); urinary bladder: 63.7931% (minimum 70%, Missing)",-0.0228814,-0.333663,-0.462062,0,1,partial,18.3,12.8,4.4,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 2); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); smooth muscle: 6.3 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 4); urinary bladder: 4.2 nTPM (protected, limit 2); stomach: 3.9 nTPM (protected, limit 2); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153721,CNKSR3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 52.4823% (minimum 75%, Missing); colon: 54.0146% (minimum 70%, Missing); duodenum: 56.9231% (minimum 75%, Missing); esophagus: 36.6337% (minimum 70%, Missing); heart muscle: 54.8148% (minimum 75%, Missing); kidney: 50.3401% (minimum 75%, Missing); liver: 44.3114% (minimum 75%, Missing); lung: 67.2727% (minimum 75%, Missing); pancreas: 28.7938% (minimum 75%, Missing); rectum: 69.1589% (minimum 70%, Missing); retina: 74.7475% (minimum 75%, Missing); salivary gland: 57.3643% (minimum 65%, Approved); small intestine: 54.4118% (minimum 75%, Missing); smooth muscle: 54.0146% (minimum 70%, Approved); spinal cord: 65.4867% (minimum 75%, Missing); spleen: 62.7119% (minimum 65%, Missing); stomach: 65.4867% (minimum 70%, Missing); urinary bladder: 63.7931% (minimum 70%, Missing)",-0.0228814,-0.333663,-0.462062,0,1,partial,18.3,12.8,4.4,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 3); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); smooth muscle: 6.3 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 4); urinary bladder: 4.2 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 3); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153721,CNKSR3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 52.4823% (minimum 75%, Missing); colon: 54.0146% (minimum 70%, Missing); duodenum: 56.9231% (minimum 75%, Missing); esophagus: 36.6337% (minimum 70%, Missing); heart muscle: 54.8148% (minimum 75%, Missing); kidney: 50.3401% (minimum 75%, Missing); liver: 44.3114% (minimum 75%, Missing); lung: 67.2727% (minimum 75%, Missing); pancreas: 28.7938% (minimum 75%, Missing); rectum: 69.1589% (minimum 70%, Missing); retina: 74.7475% (minimum 75%, Missing); salivary gland: 57.3643% (minimum 65%, Approved); small intestine: 54.4118% (minimum 75%, Missing); smooth muscle: 54.0146% (minimum 70%, Approved); spinal cord: 65.4867% (minimum 75%, Missing); spleen: 62.7119% (minimum 65%, Missing); stomach: 65.4867% (minimum 70%, Missing); urinary bladder: 63.7931% (minimum 70%, Missing)",-0.0228814,-0.333663,-0.462062,0,1,partial,18.3,12.8,4.4,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 3); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); smooth muscle: 6.3 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 4); urinary bladder: 4.2 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 3); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153721,CNKSR3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 52.4823% (minimum 75%, Baseline (adaptation disabled)); colon: 54.0146% (minimum 70%, Baseline (adaptation disabled)); duodenum: 56.9231% (minimum 75%, Baseline (adaptation disabled)); esophagus: 36.6337% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 54.8148% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.3401% (minimum 75%, Baseline (adaptation disabled)); liver: 44.3114% (minimum 75%, Baseline (adaptation disabled)); lung: 67.2727% (minimum 75%, Baseline (adaptation disabled)); pancreas: 28.7938% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.1589% (minimum 70%, Baseline (adaptation disabled)); retina: 74.7475% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 57.3643% (minimum 70%, Baseline (adaptation disabled)); small intestine: 54.4118% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 54.0146% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.4867% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.7119% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.4867% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.7931% (minimum 70%, Baseline (adaptation disabled))",-0.0228814,-0.333663,-0.462062,0,1,partial,18.3,12.8,4.4,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 3); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); smooth muscle: 6.3 nTPM (vital, limit 1); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); urinary bladder: 4.2 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 3); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153721,CNKSR3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153779,TGIF2LX,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153779,TGIF2LX,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153779,TGIF2LX,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153779,TGIF2LX,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153779,TGIF2LX,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 89.3258% (minimum 99%, Missing); amygdala: 97.5460% (minimum 99%, Missing); basal ganglia: 96.2179% (minimum 99%, Missing); bone marrow: 97.0992% (minimum 99%, Missing); cerebellum: 94.3620% (minimum 99%, Missing); cerebral cortex: 98.2998% (minimum 99%, Missing); choroid plexus: 97.5460% (minimum 99%, Missing); colon: 90.5983% (minimum 97%, Missing); duodenum: 93.6672% (minimum 99%, Missing); esophagus: 96.3636% (minimum 97%, Missing); heart muscle: 96.8037% (minimum 99%, Missing); hippocampal formation: 97.3966% (minimum 99%, Missing); hypothalamus: 97.5460% (minimum 99%, Missing); kidney: 95.9276% (minimum 99%, Missing); liver: 97.9969% (minimum 99%, Missing); lung: 96.2179% (minimum 99%, Missing); lymph node: 95.2096% (minimum 97%, Missing); midbrain: 97.3966% (minimum 99%, Missing); pancreas: 96.9512% (minimum 99%, Missing); parathyroid gland: 94.3620% (minimum 97%, Missing); pituitary gland: 96.8037% (minimum 99%, Missing); rectum: 93.5294% (minimum 97%, Missing); retina: 96.0725% (minimum 99%, Missing); salivary gland: 94.9254% (minimum 97%, Missing); skeletal muscle: 98.6047% (minimum 99%, Missing); small intestine: 94.5022% (minimum 99%, Missing); smooth muscle: 95.6391% (minimum 99%, Missing); spinal cord: 95.6391% (minimum 99%, Missing); spleen: 94.2222% (minimum 95%, Missing); stomach: 93.5294% (minimum 97%, Missing); thymus: 93.8053% (minimum 95%, Missing); thyroid gland: 94.0828% (minimum 95%, Missing); urinary bladder: 94.5022% (minimum 97%, Missing)",-0.0119469,-0.0640171,-0.0967416,0,80,unavailable,7.6,6.6,4.2,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); spinal cord: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153790,SPMIP4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288053,0.205983,0.143258,0,80,unavailable,7.6,6.6,4.2,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); spinal cord: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153790,SPMIP4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288053,0.205983,0.143258,0,80,unavailable,7.6,6.6,4.2,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); small intestine: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); lymph node: 3.2 nTPM (protected, limit 3); spinal cord: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153790,SPMIP4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288053,0.205983,0.143258,0,80,unavailable,7.6,6.6,4.2,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); small intestine: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); lymph node: 3.2 nTPM (protected, limit 3); spinal cord: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153790,SPMIP4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288053,0.205983,0.143258,0,80,unavailable,7.6,6.6,4.2,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); small intestine: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); lymph node: 3.2 nTPM (protected, limit 3); spinal cord: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153790,SPMIP4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 84.7826% (minimum 95%, Missing); adrenal gland: 31.4516% (minimum 99%, Missing); amygdala: 97.5000% (minimum 99%, Missing); basal ganglia: 97.5000% (minimum 99%, Missing); bone marrow: 59.0909% (minimum 99%, Missing); cerebral cortex: 97.5000% (minimum 99%, Missing); choroid plexus: 92.8571% (minimum 99%, Missing); colon: 28.4672% (minimum 97%, Missing); duodenum: 70.9091% (minimum 99%, Missing); esophagus: 84.7826% (minimum 97%, Missing); heart muscle: 90.6977% (minimum 99%, Missing); hippocampal formation: 95.1220% (minimum 99%, Missing); hypothalamus: 97.5000% (minimum 99%, Missing); kidney: 79.5918% (minimum 99%, Missing); liver: 86.6667% (minimum 99%, Missing); lung: 42.3913% (minimum 99%, Missing); lymph node: 23.7805% (minimum 97%, Missing); midbrain: 97.5000% (minimum 99%, Missing); pancreas: 82.9787% (minimum 99%, Missing); parathyroid gland: 78.0000% (minimum 97%, Missing); pituitary gland: 88.6364% (minimum 99%, Missing); rectum: 21.0811% (minimum 97%, Missing); salivary gland: 84.7826% (minimum 97%, Missing); skeletal muscle: 95.1220% (minimum 99%, Missing); skin: 66.1017% (minimum 95%, Missing); small intestine: 42.3913% (minimum 99%, Missing); smooth muscle: 86.6667% (minimum 99%, Missing); spinal cord: 92.8571% (minimum 99%, Missing); spleen: 37.1429% (minimum 95%, Missing); stomach: 65.0000% (minimum 97%, Missing); thymus: 63.9344% (minimum 95%, Missing); thyroid gland: 88.6364% (minimum 95%, Missing); urinary bladder: 72.2222% (minimum 97%, Missing)",-0.578571,-0.759189,-0.675484,0,80,unavailable,8.5,14.6,6.6,"rectum: 14.6 nTPM (protected, limit 2); lymph node: 12.5 nTPM (protected, limit 2); colon: 9.8 nTPM (protected, limit 2); adrenal gland: 8.5 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153898,MCOLN2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 31.4516% (minimum 75%, Missing); bone marrow: 59.0909% (minimum 75%, Missing); colon: 28.4672% (minimum 70%, Missing); duodenum: 70.9091% (minimum 75%, Missing); lung: 42.3913% (minimum 75%, Missing); lymph node: 23.7805% (minimum 70%, Missing); rectum: 21.0811% (minimum 70%, Missing); small intestine: 42.3913% (minimum 75%, Missing); spleen: 37.1429% (minimum 65%, Missing); stomach: 65.0000% (minimum 70%, Missing); thymus: 63.9344% (minimum 65%, Missing)",-0.278571,-0.489189,-0.435484,0,80,unavailable,8.5,14.6,6.6,"rectum: 14.6 nTPM (protected, limit 2); lymph node: 12.5 nTPM (protected, limit 2); colon: 9.8 nTPM (protected, limit 2); adrenal gland: 8.5 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153898,MCOLN2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 31.4516% (minimum 75%, Missing); bone marrow: 59.0909% (minimum 75%, Missing); colon: 28.4672% (minimum 70%, Missing); duodenum: 70.9091% (minimum 75%, Missing); lung: 42.3913% (minimum 75%, Missing); lymph node: 23.7805% (minimum 70%, Missing); rectum: 21.0811% (minimum 70%, Missing); small intestine: 42.3913% (minimum 75%, Missing); spleen: 37.1429% (minimum 65%, Missing); stomach: 65.0000% (minimum 70%, Missing); thymus: 63.9344% (minimum 65%, Missing)",-0.278571,-0.489189,-0.435484,0,80,unavailable,8.5,14.6,6.6,"rectum: 14.6 nTPM (protected, limit 3); lymph node: 12.5 nTPM (protected, limit 3); colon: 9.8 nTPM (protected, limit 3); adrenal gland: 8.5 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153898,MCOLN2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 31.4516% (minimum 75%, Missing); bone marrow: 59.0909% (minimum 75%, Missing); colon: 28.4672% (minimum 70%, Missing); duodenum: 70.9091% (minimum 75%, Missing); lung: 42.3913% (minimum 75%, Missing); lymph node: 23.7805% (minimum 70%, Missing); rectum: 21.0811% (minimum 70%, Missing); small intestine: 42.3913% (minimum 75%, Missing); spleen: 37.1429% (minimum 65%, Missing); stomach: 65.0000% (minimum 70%, Missing); thymus: 63.9344% (minimum 65%, Missing)",-0.278571,-0.489189,-0.435484,0,80,unavailable,8.5,14.6,6.6,"rectum: 14.6 nTPM (protected, limit 3); lymph node: 12.5 nTPM (protected, limit 3); colon: 9.8 nTPM (protected, limit 3); adrenal gland: 8.5 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153898,MCOLN2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 31.4516% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 59.0909% (minimum 75%, Baseline (adaptation disabled)); colon: 28.4672% (minimum 70%, Baseline (adaptation disabled)); duodenum: 70.9091% (minimum 75%, Baseline (adaptation disabled)); lung: 42.3913% (minimum 75%, Baseline (adaptation disabled)); lymph node: 23.7805% (minimum 70%, Baseline (adaptation disabled)); rectum: 21.0811% (minimum 70%, Baseline (adaptation disabled)); small intestine: 42.3913% (minimum 75%, Baseline (adaptation disabled)); spleen: 37.1429% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 63.9344% (minimum 65%, Baseline (adaptation disabled))",-0.278571,-0.489189,-0.435484,0,80,unavailable,8.5,14.6,6.6,"rectum: 14.6 nTPM (protected, limit 3); lymph node: 12.5 nTPM (protected, limit 3); colon: 9.8 nTPM (protected, limit 3); adrenal gland: 8.5 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153898,MCOLN2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.2222% (minimum 95%, Missing); adrenal gland: 83.0000% (minimum 99%, Missing); amygdala: 61.4815% (minimum 99%, Missing); basal ganglia: 58.8652% (minimum 99%, Missing); bone marrow: 84.6939% (minimum 99%, Missing); cerebellum: 45.3552% (minimum 99%, Missing); cerebral cortex: 41.7085% (minimum 99%, Missing); choroid plexus: 74.1071% (minimum 99%, Missing); colon: 82.1782% (minimum 97%, Missing); duodenum: 59.7122% (minimum 99%, Missing); esophagus: 91.2088% (minimum 97%, Missing); heart muscle: 88.2979% (minimum 99%, Missing); hippocampal formation: 58.0420% (minimum 99%, Missing); hypothalamus: 52.2013% (minimum 99%, Missing); kidney: 80.5825% (minimum 99%, Missing); liver: 89.2473% (minimum 99%, Missing); lung: 79.0476% (minimum 99%, Missing); lymph node: 91.2088% (minimum 97%, Missing); midbrain: 62.8788% (minimum 99%, Missing); pancreas: 89.2473% (minimum 99%, Missing); parathyroid gland: 59.2857% (minimum 97%, Missing); pituitary gland: 83.0000% (minimum 99%, Missing); rectum: 84.6939% (minimum 97%, Missing); retina: 59.7122% (minimum 99%, Missing); salivary gland: 79.0476% (minimum 97%, Missing); skeletal muscle: 83.8384% (minimum 99%, Missing); skin: 86.4583% (minimum 95%, Missing); small intestine: 66.9355% (minimum 99%, Missing); smooth muscle: 87.3684% (minimum 99%, Missing); spinal cord: 65.8730% (minimum 99%, Missing); spleen: 85.5670% (minimum 95%, Missing); stomach: 62.4060% (minimum 97%, Missing); thymus: 83.8384% (minimum 95%, Missing); thyroid gland: 76.8519% (minimum 95%, Missing); tongue: 92.2222% (minimum 97%, Missing); urinary bladder: 87.3684% (minimum 97%, Missing)",-0.181481,-0.377143,-0.572915,0,80,unavailable,11.6,5.7,2.5,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 2); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 2); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153982,GDPD1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 61.4815% (minimum 75%, Missing); basal ganglia: 58.8652% (minimum 75%, Missing); cerebellum: 45.3552% (minimum 75%, Missing); cerebral cortex: 41.7085% (minimum 75%, Missing); choroid plexus: 74.1071% (minimum 75%, Missing); duodenum: 59.7122% (minimum 75%, Missing); hippocampal formation: 58.0420% (minimum 75%, Missing); hypothalamus: 52.2013% (minimum 75%, Missing); midbrain: 62.8788% (minimum 75%, Missing); parathyroid gland: 59.2857% (minimum 70%, Missing); retina: 59.7122% (minimum 75%, Missing); small intestine: 66.9355% (minimum 75%, Missing); spinal cord: 65.8730% (minimum 75%, Missing); stomach: 62.4060% (minimum 70%, Missing)",0.118519,-0.107143,-0.332915,0,80,unavailable,11.6,5.7,2.5,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 2); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 2); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153982,GDPD1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 61.4815% (minimum 75%, Missing); basal ganglia: 58.8652% (minimum 75%, Missing); cerebellum: 45.3552% (minimum 75%, Missing); cerebral cortex: 41.7085% (minimum 75%, Missing); choroid plexus: 74.1071% (minimum 75%, Missing); duodenum: 59.7122% (minimum 75%, Missing); hippocampal formation: 58.0420% (minimum 75%, Missing); hypothalamus: 52.2013% (minimum 75%, Missing); midbrain: 62.8788% (minimum 75%, Missing); parathyroid gland: 59.2857% (minimum 70%, Missing); retina: 59.7122% (minimum 75%, Missing); small intestine: 66.9355% (minimum 75%, Missing); spinal cord: 65.8730% (minimum 75%, Missing); stomach: 62.4060% (minimum 70%, Missing)",0.118519,-0.107143,-0.332915,0,80,unavailable,11.6,5.7,2.5,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 3); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 3); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153982,GDPD1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 61.4815% (minimum 75%, Missing); basal ganglia: 58.8652% (minimum 75%, Missing); cerebellum: 45.3552% (minimum 75%, Missing); cerebral cortex: 41.7085% (minimum 75%, Missing); choroid plexus: 74.1071% (minimum 75%, Missing); duodenum: 59.7122% (minimum 75%, Missing); hippocampal formation: 58.0420% (minimum 75%, Missing); hypothalamus: 52.2013% (minimum 75%, Missing); midbrain: 62.8788% (minimum 75%, Missing); parathyroid gland: 59.2857% (minimum 70%, Missing); retina: 59.7122% (minimum 75%, Missing); small intestine: 66.9355% (minimum 75%, Missing); spinal cord: 65.8730% (minimum 75%, Missing); stomach: 62.4060% (minimum 70%, Missing)",0.118519,-0.107143,-0.332915,0,80,unavailable,11.6,5.7,2.5,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 3); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 3); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153982,GDPD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 61.4815% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.8652% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 45.3552% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 41.7085% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.1071% (minimum 75%, Baseline (adaptation disabled)); duodenum: 59.7122% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.0420% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 52.2013% (minimum 75%, Baseline (adaptation disabled)); midbrain: 62.8788% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.2857% (minimum 70%, Baseline (adaptation disabled)); retina: 59.7122% (minimum 75%, Baseline (adaptation disabled)); small intestine: 66.9355% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.8730% (minimum 75%, Baseline (adaptation disabled)); stomach: 62.4060% (minimum 70%, Baseline (adaptation disabled))",0.118519,-0.107143,-0.332915,0,80,unavailable,11.6,5.7,2.5,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 3); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 3); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000153982,GDPD1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.00589322,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154007,ASB17,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245893,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154007,ASB17,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245893,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154007,ASB17,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245893,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154007,ASB17,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245893,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154007,ASB17,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.3011% (minimum 99%, Missing); basal ganglia: 98.9936% (minimum 99%, Missing); choroid plexus: 95.8739% (minimum 99%, Missing); hippocampal formation: 97.6829% (minimum 99%, Missing); hypothalamus: 98.2357% (minimum 99%, Missing); midbrain: 98.2684% (minimum 99%, Missing); pituitary gland: 97.3606% (minimum 99%, Missing); retina: 98.2030% (minimum 99%, Missing); spinal cord: 97.7800% (minimum 99%, Missing)",0.0452782,0.0296612,-0.0312606,0,1,partial,12.7,2.3,2,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 6); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154040,CABYR,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345278,0.299661,0.208739,0,1,partial,12.7,2.3,2,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 6); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154040,CABYR,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345278,0.299661,0.208739,0,1,partial,12.7,2.3,2,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 6); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154040,CABYR,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345278,0.299661,0.208739,0,1,partial,12.7,2.3,2,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 6); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154040,CABYR,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343268,0.292266,0.208739,0,1,partial,12.7,2.3,2,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154040,CABYR,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1075% (minimum 90%, Approved); adrenal gland: 62.1974% (minimum 99%, Missing); amygdala: 73.8938% (minimum 99%, Missing); basal ganglia: 71.5203% (minimum 99%, Missing); bone marrow: 68.1633% (minimum 99%, Missing); cerebellum: 91.0082% (minimum 99%, Missing); cerebral cortex: 70.0210% (minimum 99%, Missing); choroid plexus: 78.9598% (minimum 99%, Missing); colon: 65.7480% (minimum 97%, Missing); duodenum: 68.1633% (minimum 99%, Missing); esophagus: 61.3971% (minimum 97%, Missing); heart muscle: 64.2308% (minimum 99%, Missing); hippocampal formation: 77.4942% (minimum 99%, Missing); hypothalamus: 65.7480% (minimum 99%, Missing); kidney: 58.6995% (minimum 99%, Missing); liver: 60.7273% (minimum 98%, Approved); lung: 68.7243% (minimum 98%, Approved); lymph node: 74.8879% (minimum 97%, Missing); midbrain: 71.5203% (minimum 99%, Missing); pancreas: 62.6642% (minimum 99%, Missing); parathyroid gland: 55.3897% (minimum 95%, Approved); pituitary gland: 77.4942% (minimum 99%, Missing); rectum: 69.8745% (minimum 97%, Missing); retina: 77.3148% (minimum 99%, Missing); salivary gland: 57.9861% (minimum 97%, Missing); skeletal muscle: 63.0189% (minimum 99%, Missing); skin: 75.0562% (minimum 95%, Missing); small intestine: 67.6113% (minimum 99%, Missing); smooth muscle: 72.7669% (minimum 99%, Missing); spinal cord: 68.7243% (minimum 99%, Missing); spleen: 69.2946% (minimum 90%, Approved); stomach: 68.4426% (minimum 97%, Missing); thymus: 75.3950% (minimum 95%, Missing); thyroid gland: 51.4638% (minimum 95%, Missing); tongue: 72.6087% (minimum 97%, Missing); urinary bladder: 73.2456% (minimum 97%, Missing)",-0.435362,-0.396103,-0.403005,0,3,partial,23.5,26.9,31.5,"thyroid gland: 31.5 nTPM (manageable, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 4); salivary gland: 24.2 nTPM (protected, limit 2); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 2); esophagus: 21 nTPM (protected, limit 2); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (manageable, limit 10); heart muscle: 18.6 nTPM (vital, limit 1); hypothalamus: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 2); spinal cord: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 2); spleen: 14.8 nTPM (manageable, limit 10); rectum: 14.4 nTPM (protected, limit 2); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 2); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); amygdala: 11.8 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 2); skin: 11.1 nTPM (manageable, limit 5); thymus: 10.9 nTPM (manageable, limit 5); retina: 9.8 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154059,IMPACT,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.1974% (minimum 75%, Missing); amygdala: 73.8938% (minimum 75%, Missing); basal ganglia: 71.5203% (minimum 75%, Missing); bone marrow: 68.1633% (minimum 75%, Missing); cerebral cortex: 70.0210% (minimum 75%, Missing); colon: 65.7480% (minimum 70%, Missing); duodenum: 68.1633% (minimum 75%, Missing); esophagus: 61.3971% (minimum 70%, Missing); heart muscle: 64.2308% (minimum 75%, Missing); hypothalamus: 65.7480% (minimum 75%, Missing); kidney: 58.6995% (minimum 75%, Missing); liver: 60.7273% (minimum 70%, Approved); lung: 68.7243% (minimum 70%, Approved); midbrain: 71.5203% (minimum 75%, Missing); pancreas: 62.6642% (minimum 75%, Missing); parathyroid gland: 55.3897% (minimum 65%, Approved); rectum: 69.8745% (minimum 70%, Missing); salivary gland: 57.9861% (minimum 70%, Missing); skeletal muscle: 63.0189% (minimum 75%, Missing); small intestine: 67.6113% (minimum 75%, Missing); smooth muscle: 72.7669% (minimum 75%, Missing); spinal cord: 68.7243% (minimum 75%, Missing); stomach: 68.4426% (minimum 70%, Missing); thyroid gland: 51.4638% (minimum 65%, Missing)",-0.135362,-0.120139,-0.163005,0,3,partial,23.5,26.9,31.5,"thyroid gland: 31.5 nTPM (manageable, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 4); salivary gland: 24.2 nTPM (protected, limit 2); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 2); esophagus: 21 nTPM (protected, limit 2); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (manageable, limit 10); heart muscle: 18.6 nTPM (vital, limit 1); hypothalamus: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 2); spinal cord: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 2); spleen: 14.8 nTPM (manageable, limit 10); rectum: 14.4 nTPM (protected, limit 2); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 2); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); amygdala: 11.8 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 2); skin: 11.1 nTPM (manageable, limit 5); thymus: 10.9 nTPM (manageable, limit 5); retina: 9.8 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154059,IMPACT,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.1974% (minimum 75%, Missing); amygdala: 73.8938% (minimum 75%, Missing); basal ganglia: 71.5203% (minimum 75%, Missing); bone marrow: 68.1633% (minimum 75%, Missing); cerebral cortex: 70.0210% (minimum 75%, Missing); colon: 65.7480% (minimum 70%, Missing); duodenum: 68.1633% (minimum 75%, Missing); esophagus: 61.3971% (minimum 70%, Missing); heart muscle: 64.2308% (minimum 75%, Missing); hypothalamus: 65.7480% (minimum 75%, Missing); kidney: 58.6995% (minimum 75%, Missing); liver: 60.7273% (minimum 70%, Approved); lung: 68.7243% (minimum 70%, Approved); midbrain: 71.5203% (minimum 75%, Missing); pancreas: 62.6642% (minimum 75%, Missing); parathyroid gland: 55.3897% (minimum 65%, Approved); rectum: 69.8745% (minimum 70%, Missing); salivary gland: 57.9861% (minimum 70%, Missing); skeletal muscle: 63.0189% (minimum 75%, Missing); small intestine: 67.6113% (minimum 75%, Missing); smooth muscle: 72.7669% (minimum 75%, Missing); spinal cord: 68.7243% (minimum 75%, Missing); stomach: 68.4426% (minimum 70%, Missing); thyroid gland: 51.4638% (minimum 65%, Missing)",-0.135362,-0.120139,-0.163005,0,3,partial,23.5,26.9,31.5,"thyroid gland: 31.5 nTPM (manageable, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 4); salivary gland: 24.2 nTPM (protected, limit 3); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 2); esophagus: 21 nTPM (protected, limit 3); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (manageable, limit 10); heart muscle: 18.6 nTPM (vital, limit 1); hypothalamus: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 3); spinal cord: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 2); spleen: 14.8 nTPM (manageable, limit 10); rectum: 14.4 nTPM (protected, limit 3); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 3); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); amygdala: 11.8 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 3); skin: 11.1 nTPM (manageable, limit 5); thymus: 10.9 nTPM (manageable, limit 5); retina: 9.8 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154059,IMPACT,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.1974% (minimum 75%, Missing); amygdala: 73.8938% (minimum 75%, Missing); basal ganglia: 71.5203% (minimum 75%, Missing); bone marrow: 68.1633% (minimum 75%, Missing); cerebral cortex: 70.0210% (minimum 75%, Missing); colon: 65.7480% (minimum 70%, Missing); duodenum: 68.1633% (minimum 75%, Missing); esophagus: 61.3971% (minimum 70%, Missing); heart muscle: 64.2308% (minimum 75%, Missing); hypothalamus: 65.7480% (minimum 75%, Missing); kidney: 58.6995% (minimum 75%, Missing); liver: 60.7273% (minimum 70%, Approved); lung: 68.7243% (minimum 70%, Approved); midbrain: 71.5203% (minimum 75%, Missing); pancreas: 62.6642% (minimum 75%, Missing); parathyroid gland: 55.3897% (minimum 65%, Approved); rectum: 69.8745% (minimum 70%, Missing); salivary gland: 57.9861% (minimum 70%, Missing); skeletal muscle: 63.0189% (minimum 75%, Missing); small intestine: 67.6113% (minimum 75%, Missing); smooth muscle: 72.7669% (minimum 75%, Missing); spinal cord: 68.7243% (minimum 75%, Missing); stomach: 68.4426% (minimum 70%, Missing); thyroid gland: 51.4638% (minimum 65%, Missing)",-0.135362,-0.120139,-0.163005,0,3,partial,23.5,26.9,31.5,"thyroid gland: 31.5 nTPM (manageable, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 4); salivary gland: 24.2 nTPM (protected, limit 3); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 2); esophagus: 21 nTPM (protected, limit 3); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (manageable, limit 10); heart muscle: 18.6 nTPM (vital, limit 1); hypothalamus: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 3); spinal cord: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 2); spleen: 14.8 nTPM (manageable, limit 10); rectum: 14.4 nTPM (protected, limit 3); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 3); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); amygdala: 11.8 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 3); skin: 11.1 nTPM (manageable, limit 5); thymus: 10.9 nTPM (manageable, limit 5); retina: 9.8 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154059,IMPACT,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1075% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.1974% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.8938% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.5203% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 68.1633% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.0210% (minimum 75%, Baseline (adaptation disabled)); colon: 65.7480% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.1633% (minimum 75%, Baseline (adaptation disabled)); esophagus: 61.3971% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.2308% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.7480% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.6995% (minimum 75%, Baseline (adaptation disabled)); liver: 60.7273% (minimum 75%, Baseline (adaptation disabled)); lung: 68.7243% (minimum 75%, Baseline (adaptation disabled)); midbrain: 71.5203% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.6642% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.3897% (minimum 70%, Baseline (adaptation disabled)); rectum: 69.8745% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 57.9861% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 63.0189% (minimum 75%, Baseline (adaptation disabled)); small intestine: 67.6113% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.7669% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.7243% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.4426% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 51.4638% (minimum 65%, Baseline (adaptation disabled))",-0.135362,-0.146103,-0.163005,0,3,partial,23.5,26.9,31.5,"thyroid gland: 31.5 nTPM (manageable, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 3); salivary gland: 24.2 nTPM (protected, limit 3); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 3); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (manageable, limit 5); heart muscle: 18.6 nTPM (vital, limit 1); hypothalamus: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 3); spinal cord: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); spleen: 14.8 nTPM (manageable, limit 5); rectum: 14.4 nTPM (protected, limit 3); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 3); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); amygdala: 11.8 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 3); skin: 11.1 nTPM (manageable, limit 5); thymus: 10.9 nTPM (manageable, limit 5); retina: 9.8 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154059,IMPACT,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 92.6160% (minimum 99%, Missing); basal ganglia: 89.0467% (minimum 99%, Missing); choroid plexus: 64.9408% (minimum 99%, Missing); hippocampal formation: 89.4094% (minimum 99%, Missing); hypothalamus: 84.4231% (minimum 99%, Missing); lung: 92.8118% (minimum 95%, Enhanced); midbrain: 97.5556% (minimum 99%, Missing); pituitary gland: 95.0216% (minimum 99%, Missing); spinal cord: 97.1239% (minimum 99%, Missing)",0.05,0.03,-0.340592,0,5,partial,23.7,0.4,1.5,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154099,DNAAF1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 64.9408% (minimum 75%, Missing)",0.35,0.3,-0.100592,0,5,partial,23.7,0.4,1.5,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154099,DNAAF1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 64.9408% (minimum 75%, Missing)",0.35,0.3,-0.100592,0,5,partial,23.7,0.4,1.5,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154099,DNAAF1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 64.9408% (minimum 75%, Missing)",0.35,0.3,-0.100592,0,5,partial,23.7,0.4,1.5,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154099,DNAAF1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 64.9408% (minimum 75%, Baseline (adaptation disabled))",0.31696,0.290971,-0.100592,0,5,partial,23.7,0.4,1.5,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154099,DNAAF1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7959% (minimum 90%, Approved); adrenal gland: 63.5000% (minimum 99%, Missing); amygdala: 74.2690% (minimum 99%, Missing); basal ganglia: 72.1591% (minimum 99%, Missing); bone marrow: 69.7802% (minimum 99%, Missing); cerebellum: 72.9885% (minimum 99%, Missing); cerebral cortex: 66.1458% (minimum 99%, Missing); choroid plexus: 46.8635% (minimum 99%, Missing); colon: 64.4670% (minimum 97%, Missing); duodenum: 72.5714% (minimum 99%, Missing); esophagus: 69.7802% (minimum 97%, Missing); heart muscle: 57.9909% (minimum 99%, Missing); hippocampal formation: 71.7514% (minimum 99%, Missing); hypothalamus: 72.9885% (minimum 99%, Missing); kidney: 62.5616% (minimum 99%, Missing); liver: 47.3881% (minimum 98%, Approved); lung: 58.2569% (minimum 99%, Missing); lymph node: 64.4670% (minimum 97%, Missing); midbrain: 71.7514% (minimum 99%, Missing); pancreas: 68.2796% (minimum 99%, Missing); parathyroid gland: 46.0145% (minimum 97%, Missing); pituitary gland: 62.8713% (minimum 99%, Missing); rectum: 69.7802% (minimum 97%, Missing); retina: 61.3527% (minimum 99%, Missing); salivary gland: 65.4639% (minimum 97%, Missing); skeletal muscle: 69.0217% (minimum 99%, Missing); skin: 72.9885% (minimum 95%, Missing); small intestine: 69.7802% (minimum 99%, Missing); smooth muscle: 58.7963% (minimum 99%, Missing); spinal cord: 67.5532% (minimum 99%, Missing); spleen: 62.2549% (minimum 95%, Missing); stomach: 69.0217% (minimum 97%, Missing); thymus: 64.7959% (minimum 95%, Missing); thyroid gland: 56.6964% (minimum 95%, Missing); tongue: 63.1841% (minimum 97%, Missing); urinary bladder: 68.2796% (minimum 97%, Missing)",-0.383036,-0.509855,-0.521365,0,4,partial,14.4,14.9,9.7,"parathyroid gland: 14.9 nTPM (protected, limit 2); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); adrenal gland: 7.3 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 2); lymph node: 7 nTPM (protected, limit 2); thymus: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 2); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 2); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); small intestine: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); bone marrow: 5.5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154114,TBCEL,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.5000% (minimum 75%, Missing); amygdala: 74.2690% (minimum 75%, Missing); basal ganglia: 72.1591% (minimum 75%, Missing); bone marrow: 69.7802% (minimum 75%, Missing); cerebellum: 72.9885% (minimum 75%, Missing); cerebral cortex: 66.1458% (minimum 75%, Missing); choroid plexus: 46.8635% (minimum 75%, Missing); colon: 64.4670% (minimum 70%, Missing); duodenum: 72.5714% (minimum 75%, Missing); esophagus: 69.7802% (minimum 70%, Missing); heart muscle: 57.9909% (minimum 75%, Missing); hippocampal formation: 71.7514% (minimum 75%, Missing); hypothalamus: 72.9885% (minimum 75%, Missing); kidney: 62.5616% (minimum 75%, Missing); liver: 47.3881% (minimum 70%, Approved); lung: 58.2569% (minimum 75%, Missing); lymph node: 64.4670% (minimum 70%, Missing); midbrain: 71.7514% (minimum 75%, Missing); pancreas: 68.2796% (minimum 75%, Missing); parathyroid gland: 46.0145% (minimum 70%, Missing); pituitary gland: 62.8713% (minimum 75%, Missing); rectum: 69.7802% (minimum 70%, Missing); retina: 61.3527% (minimum 75%, Missing); salivary gland: 65.4639% (minimum 70%, Missing); skeletal muscle: 69.0217% (minimum 75%, Missing); small intestine: 69.7802% (minimum 75%, Missing); smooth muscle: 58.7963% (minimum 75%, Missing); spinal cord: 67.5532% (minimum 75%, Missing); spleen: 62.2549% (minimum 65%, Missing); stomach: 69.0217% (minimum 70%, Missing); thymus: 64.7959% (minimum 65%, Missing); thyroid gland: 56.6964% (minimum 65%, Missing); tongue: 63.1841% (minimum 70%, Missing); urinary bladder: 68.2796% (minimum 70%, Missing)",-0.0830357,-0.239855,-0.281365,0,4,partial,14.4,14.9,9.7,"parathyroid gland: 14.9 nTPM (protected, limit 2); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); adrenal gland: 7.3 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 2); lymph node: 7 nTPM (protected, limit 2); thymus: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 2); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 2); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); small intestine: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); bone marrow: 5.5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154114,TBCEL,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.5000% (minimum 75%, Missing); amygdala: 74.2690% (minimum 75%, Missing); basal ganglia: 72.1591% (minimum 75%, Missing); bone marrow: 69.7802% (minimum 75%, Missing); cerebellum: 72.9885% (minimum 75%, Missing); cerebral cortex: 66.1458% (minimum 75%, Missing); choroid plexus: 46.8635% (minimum 75%, Missing); colon: 64.4670% (minimum 70%, Missing); duodenum: 72.5714% (minimum 75%, Missing); esophagus: 69.7802% (minimum 70%, Missing); heart muscle: 57.9909% (minimum 75%, Missing); hippocampal formation: 71.7514% (minimum 75%, Missing); hypothalamus: 72.9885% (minimum 75%, Missing); kidney: 62.5616% (minimum 75%, Missing); liver: 47.3881% (minimum 70%, Approved); lung: 58.2569% (minimum 75%, Missing); lymph node: 64.4670% (minimum 70%, Missing); midbrain: 71.7514% (minimum 75%, Missing); pancreas: 68.2796% (minimum 75%, Missing); parathyroid gland: 46.0145% (minimum 70%, Missing); pituitary gland: 62.8713% (minimum 75%, Missing); rectum: 69.7802% (minimum 70%, Missing); retina: 61.3527% (minimum 75%, Missing); salivary gland: 65.4639% (minimum 70%, Missing); skeletal muscle: 69.0217% (minimum 75%, Missing); small intestine: 69.7802% (minimum 75%, Missing); smooth muscle: 58.7963% (minimum 75%, Missing); spinal cord: 67.5532% (minimum 75%, Missing); spleen: 62.2549% (minimum 65%, Missing); stomach: 69.0217% (minimum 70%, Missing); thymus: 64.7959% (minimum 65%, Missing); thyroid gland: 56.6964% (minimum 65%, Missing); tongue: 63.1841% (minimum 70%, Missing); urinary bladder: 68.2796% (minimum 70%, Missing)",-0.0830357,-0.239855,-0.281365,0,4,partial,14.4,14.9,9.7,"parathyroid gland: 14.9 nTPM (protected, limit 3); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); adrenal gland: 7.3 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 3); lymph node: 7 nTPM (protected, limit 3); thymus: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 3); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 3); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); small intestine: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); bone marrow: 5.5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154114,TBCEL,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.5000% (minimum 75%, Missing); amygdala: 74.2690% (minimum 75%, Missing); basal ganglia: 72.1591% (minimum 75%, Missing); bone marrow: 69.7802% (minimum 75%, Missing); cerebellum: 72.9885% (minimum 75%, Missing); cerebral cortex: 66.1458% (minimum 75%, Missing); choroid plexus: 46.8635% (minimum 75%, Missing); colon: 64.4670% (minimum 70%, Missing); duodenum: 72.5714% (minimum 75%, Missing); esophagus: 69.7802% (minimum 70%, Missing); heart muscle: 57.9909% (minimum 75%, Missing); hippocampal formation: 71.7514% (minimum 75%, Missing); hypothalamus: 72.9885% (minimum 75%, Missing); kidney: 62.5616% (minimum 75%, Missing); liver: 47.3881% (minimum 70%, Approved); lung: 58.2569% (minimum 75%, Missing); lymph node: 64.4670% (minimum 70%, Missing); midbrain: 71.7514% (minimum 75%, Missing); pancreas: 68.2796% (minimum 75%, Missing); parathyroid gland: 46.0145% (minimum 70%, Missing); pituitary gland: 62.8713% (minimum 75%, Missing); rectum: 69.7802% (minimum 70%, Missing); retina: 61.3527% (minimum 75%, Missing); salivary gland: 65.4639% (minimum 70%, Missing); skeletal muscle: 69.0217% (minimum 75%, Missing); small intestine: 69.7802% (minimum 75%, Missing); smooth muscle: 58.7963% (minimum 75%, Missing); spinal cord: 67.5532% (minimum 75%, Missing); spleen: 62.2549% (minimum 65%, Missing); stomach: 69.0217% (minimum 70%, Missing); thymus: 64.7959% (minimum 65%, Missing); thyroid gland: 56.6964% (minimum 65%, Missing); tongue: 63.1841% (minimum 70%, Missing); urinary bladder: 68.2796% (minimum 70%, Missing)",-0.0830357,-0.239855,-0.281365,0,4,partial,14.4,14.9,9.7,"parathyroid gland: 14.9 nTPM (protected, limit 3); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); adrenal gland: 7.3 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 3); lymph node: 7 nTPM (protected, limit 3); thymus: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 3); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 3); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); small intestine: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); bone marrow: 5.5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154114,TBCEL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7959% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.5000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 74.2690% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 72.1591% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 69.7802% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.9885% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.1458% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 46.8635% (minimum 75%, Baseline (adaptation disabled)); colon: 64.4670% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.5714% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.7802% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 57.9909% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.7514% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.9885% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.5616% (minimum 75%, Baseline (adaptation disabled)); liver: 47.3881% (minimum 75%, Baseline (adaptation disabled)); lung: 58.2569% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.4670% (minimum 70%, Baseline (adaptation disabled)); midbrain: 71.7514% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.2796% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 46.0145% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.8713% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.7802% (minimum 70%, Baseline (adaptation disabled)); retina: 61.3527% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.4639% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 69.0217% (minimum 75%, Baseline (adaptation disabled)); small intestine: 69.7802% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.7963% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.5532% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.2549% (minimum 65%, Baseline (adaptation disabled)); stomach: 69.0217% (minimum 70%, Baseline (adaptation disabled)); thymus: 64.7959% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.6964% (minimum 65%, Baseline (adaptation disabled)); tongue: 63.1841% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 68.2796% (minimum 70%, Baseline (adaptation disabled))",-0.0830357,-0.239855,-0.281365,0,4,partial,14.4,14.9,9.7,"parathyroid gland: 14.9 nTPM (protected, limit 3); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); adrenal gland: 7.3 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 3); colon: 7 nTPM (protected, limit 3); thymus: 6.9 nTPM (manageable, limit 5); adipose tissue: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 3); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 3); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 3); bone marrow: 5.5 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 3); esophagus: 5.5 nTPM (protected, limit 3); midbrain: 5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154114,TBCEL,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 50.0000% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing)",0.05,-0.47,-0.49,0,80,unavailable,0.2,0.2,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154143,PANX3,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 50.0000% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing)",0.35,-0.2,-0.25,0,80,unavailable,0.2,0.2,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154143,PANX3,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 50.0000% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing)",0.35,-0.2,-0.25,0,80,unavailable,0.2,0.2,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154143,PANX3,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 50.0000% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing)",0.35,-0.2,-0.25,0,80,unavailable,0.2,0.2,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154143,PANX3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.2,-0.25,0,80,unavailable,0.2,0.2,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154143,PANX3,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 35.4217% (minimum 97%, Missing); pituitary gland: 98.9899% (minimum 99%, Missing); salivary gland: 78.1915% (minimum 95%, Approved); skeletal muscle: 98.0000% (minimum 99%, Missing); skin: 32.1663% (minimum 95%, Missing)",-0.628337,-0.615783,-0.01,0,2,partial,0.6,53.6,62,"skin: 62 nTPM (manageable, limit 5); esophagus: 53.6 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 4)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154227,CERS3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 35.4217% (minimum 70%, Missing); skin: 32.1663% (minimum 65%, Missing)",-0.328337,-0.345783,0.23,0,2,partial,0.6,53.6,62,"skin: 62 nTPM (manageable, limit 5); esophagus: 53.6 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 4)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154227,CERS3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 35.4217% (minimum 70%, Missing); skin: 32.1663% (minimum 65%, Missing)",-0.328337,-0.345783,0.23,0,2,partial,0.6,53.6,62,"skin: 62 nTPM (manageable, limit 5); esophagus: 53.6 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 4)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154227,CERS3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 35.4217% (minimum 70%, Missing); skin: 32.1663% (minimum 65%, Missing)",-0.328337,-0.345783,0.23,0,2,partial,0.6,53.6,62,"skin: 62 nTPM (manageable, limit 5); esophagus: 53.6 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 4)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154227,CERS3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 35.4217% (minimum 70%, Baseline (adaptation disabled)); skin: 32.1663% (minimum 65%, Baseline (adaptation disabled))",-0.328337,-0.345783,0.23,0,2,partial,0.6,53.6,62,"skin: 62 nTPM (manageable, limit 5); esophagus: 53.6 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154227,CERS3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154438,ASZ1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154438,ASZ1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154438,ASZ1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154438,ASZ1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154438,ASZ1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.9309% (minimum 99%, Missing); basal ganglia: 95.1100% (minimum 99%, Missing); bone marrow: 95.5774% (minimum 98%, Approved); cerebral cortex: 95.2264% (minimum 98%, Approved); choroid plexus: 62.8941% (minimum 99%, Missing); hippocampal formation: 94.6472% (minimum 99%, Missing); hypothalamus: 94.7625% (minimum 99%, Missing); lung: 97.0075% (minimum 98%, Approved); midbrain: 97.9849% (minimum 99%, Missing); pancreas: 98.2323% (minimum 99%, Missing); pituitary gland: 96.8867% (minimum 99%, Missing); retina: 92.2894% (minimum 99%, Missing); spinal cord: 97.9849% (minimum 99%, Missing)",0.0474359,0.0274359,-0.361059,0,6,partial,45.9,1.5,3.3,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 2); bone marrow: 3.6 nTPM (vital, limit 2); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154479,CFAP210,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 62.8941% (minimum 75%, Missing)",0.347436,0.297436,-0.121059,0,6,partial,45.9,1.5,3.3,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 2); bone marrow: 3.6 nTPM (vital, limit 2); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154479,CFAP210,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 62.8941% (minimum 75%, Missing)",0.347436,0.297436,-0.121059,0,6,partial,45.9,1.5,3.3,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 2); bone marrow: 3.6 nTPM (vital, limit 2); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154479,CFAP210,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 62.8941% (minimum 75%, Missing)",0.347436,0.297436,-0.121059,0,6,partial,45.9,1.5,3.3,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 2); bone marrow: 3.6 nTPM (vital, limit 2); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154479,CFAP210,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 62.8941% (minimum 75%, Baseline (adaptation disabled))",0.309309,0.281084,-0.121059,0,6,partial,45.9,1.5,3.3,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154479,CFAP210,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.5217% (minimum 98%, Approved); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 77.0833% (minimum 99%, Missing); bone marrow: 96.5217% (minimum 98%, Approved); cerebellum: 76.5517% (minimum 98%, Approved); cerebral cortex: 72.5490% (minimum 98%, Approved); choroid plexus: 95.6897% (minimum 99%, Missing); colon: 94.8718% (minimum 95%, Approved); heart muscle: 96.5217% (minimum 98%, Approved); hippocampal formation: 78.7234% (minimum 99%, Missing); hypothalamus: 74.0000% (minimum 99%, Missing); kidney: 86.7188% (minimum 98%, Approved); liver: 97.3684% (minimum 98%, Approved); lung: 96.5217% (minimum 98%, Approved); midbrain: 86.0465% (minimum 99%, Missing); pancreas: 94.8718% (minimum 98%, Approved); parathyroid gland: 88.0952% (minimum 97%, Missing); pituitary gland: 81.6176% (minimum 99%, Missing); retina: 82.8358% (minimum 99%, Missing); smooth muscle: 92.5000% (minimum 98%, Approved); spinal cord: 91.7355% (minimum 99%, Missing); urinary bladder: 94.0678% (minimum 95%, Approved)",0.00243902,-0.0890476,-0.25451,0,3,partial,4.2,1.5,1.2,"cerebral cortex: 4.2 nTPM (vital, limit 2); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 2); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154548,SRSF12,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); hypothalamus: 74.0000% (minimum 75%, Missing)",0.302439,0.180952,-0.01,0,3,partial,4.2,1.5,1.2,"cerebral cortex: 4.2 nTPM (vital, limit 2); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 2); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154548,SRSF12,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); hypothalamus: 74.0000% (minimum 75%, Missing)",0.302439,0.180952,-0.01,0,3,partial,4.2,1.5,1.2,"cerebral cortex: 4.2 nTPM (vital, limit 2); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 2); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154548,SRSF12,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); hypothalamus: 74.0000% (minimum 75%, Missing)",0.302439,0.180952,-0.01,0,3,partial,4.2,1.5,1.2,"cerebral cortex: 4.2 nTPM (vital, limit 2); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 2); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154548,SRSF12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 75.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.5490% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.0000% (minimum 75%, Baseline (adaptation disabled))",0.252439,0.180952,-0.0245098,0,3,partial,4.2,1.5,1.2,"cerebral cortex: 4.2 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154548,SRSF12,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 92.6554% (minimum 97%, Missing)",0.0204142,-0.0434463,0.00393939,0,80,unavailable,0.1,1.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154611,PSMA8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.320414,0.226554,0.243939,0,80,unavailable,0.1,1.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154611,PSMA8,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.320414,0.226554,0.243939,0,80,unavailable,0.1,1.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154611,PSMA8,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.320414,0.226554,0.243939,0,80,unavailable,0.1,1.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154611,PSMA8,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.320414,0.226554,0.243939,0,80,unavailable,0.1,1.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154611,PSMA8,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.7695% (minimum 95%, Enhanced); amygdala: 97.4110% (minimum 99%, Missing); basal ganglia: 93.7695% (minimum 99%, Missing); choroid plexus: 96.4744% (minimum 99%, Missing); colon: 91.7683% (minimum 97%, Missing); duodenum: 94.9527% (minimum 99%, Missing); heart muscle: 89.5833% (minimum 95%, Enhanced); hippocampal formation: 96.1661% (minimum 99%, Missing); hypothalamus: 79.2105% (minimum 99%, Missing); kidney: 89.5833% (minimum 95%, Enhanced); midbrain: 95.8599% (minimum 99%, Missing); pituitary gland: 92.6154% (minimum 99%, Missing); rectum: 89.8507% (minimum 97%, Missing); retina: 98.0456% (minimum 99%, Missing); small intestine: 97.0968% (minimum 99%, Missing); spinal cord: 93.1889% (minimum 99%, Missing); tongue: 94.9527% (minimum 97%, Missing)",0.0401316,-0.0714925,-0.197895,0,2,partial,7.9,3.4,13.7,"hypothalamus: 7.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154645,CHODL,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.187215,0.198507,0.0421053,0,2,partial,7.9,3.4,13.7,"hypothalamus: 7.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154645,CHODL,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.187215,0.198507,0.0421053,0,2,partial,7.9,3.4,13.7,"hypothalamus: 7.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154645,CHODL,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.187215,0.198507,0.0421053,0,2,partial,7.9,3.4,13.7,"hypothalamus: 7.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154645,CHODL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0372146,0.198507,0.0421053,0,2,partial,7.9,3.4,13.7,"spleen: 13.7 nTPM (manageable, limit 5); hypothalamus: 7.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154645,CHODL,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.9211% (minimum 90%, Approved); adrenal gland: 74.5455% (minimum 99%, Missing); amygdala: 78.8462% (minimum 99%, Missing); basal ganglia: 82.5503% (minimum 99%, Missing); bone marrow: 89.7810% (minimum 99%, Missing); cerebellum: 97.6190% (minimum 99%, Missing); cerebral cortex: 79.3548% (minimum 99%, Missing); choroid plexus: 84.8276% (minimum 99%, Missing); colon: 86.0140% (minimum 97%, Missing); duodenum: 80.9211% (minimum 98%, Approved); esophagus: 78.3439% (minimum 97%, Missing); heart muscle: 71.9298% (minimum 98%, Approved); hippocampal formation: 77.8481% (minimum 99%, Missing); hypothalamus: 83.6735% (minimum 99%, Missing); kidney: 64.0625% (minimum 99%, Missing); liver: 59.1346% (minimum 98%, Approved); lung: 76.8750% (minimum 99%, Missing); lymph node: 86.6197% (minimum 97%, Missing); midbrain: 79.3548% (minimum 99%, Missing); pancreas: 66.1290% (minimum 99%, Missing); parathyroid gland: 60.0000% (minimum 95%, Approved); pituitary gland: 79.8701% (minimum 99%, Missing); rectum: 86.6197% (minimum 95%, Approved); retina: 88.4892% (minimum 99%, Missing); salivary gland: 79.3548% (minimum 97%, Missing); skeletal muscle: 93.1818% (minimum 99%, Missing); skin: 63.7306% (minimum 95%, Missing); small intestine: 78.3439% (minimum 99%, Missing); smooth muscle: 91.1111% (minimum 99%, Missing); spinal cord: 84.2466% (minimum 99%, Missing); spleen: 81.4570% (minimum 90%, Approved); stomach: 79.8701% (minimum 97%, Missing); thymus: 81.4570% (minimum 95%, Missing); thyroid gland: 68.7151% (minimum 95%, Missing); tongue: 90.4412% (minimum 97%, Missing); urinary bladder: 89.7810% (minimum 97%, Missing)",-0.312694,-0.35,-0.388654,0,2,partial,8.5,8.2,7,"liver: 8.5 nTPM (vital, limit 2); parathyroid gland: 8.2 nTPM (protected, limit 4); skin: 7 nTPM (manageable, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); heart muscle: 4.8 nTPM (vital, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 2); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); stomach: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154655,L3MBTL4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.5455% (minimum 75%, Missing); kidney: 64.0625% (minimum 75%, Missing); liver: 59.1346% (minimum 70%, Approved); pancreas: 66.1290% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 65%, Approved); skin: 63.7306% (minimum 65%, Missing)",-0.0126943,-0.05,-0.109375,0,2,partial,8.5,8.2,7,"liver: 8.5 nTPM (vital, limit 2); parathyroid gland: 8.2 nTPM (protected, limit 4); skin: 7 nTPM (manageable, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); heart muscle: 4.8 nTPM (vital, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 2); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); stomach: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154655,L3MBTL4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.5455% (minimum 75%, Missing); kidney: 64.0625% (minimum 75%, Missing); liver: 59.1346% (minimum 70%, Approved); pancreas: 66.1290% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 65%, Approved); skin: 63.7306% (minimum 65%, Missing)",-0.0126943,-0.05,-0.109375,0,2,partial,8.5,8.2,7,"liver: 8.5 nTPM (vital, limit 2); parathyroid gland: 8.2 nTPM (protected, limit 4); skin: 7 nTPM (manageable, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); heart muscle: 4.8 nTPM (vital, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 3); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); stomach: 3.1 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154655,L3MBTL4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.5455% (minimum 75%, Missing); kidney: 64.0625% (minimum 75%, Missing); liver: 59.1346% (minimum 70%, Approved); pancreas: 66.1290% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 65%, Approved); skin: 63.7306% (minimum 65%, Missing)",-0.0126943,-0.05,-0.109375,0,2,partial,8.5,8.2,7,"liver: 8.5 nTPM (vital, limit 2); parathyroid gland: 8.2 nTPM (protected, limit 4); skin: 7 nTPM (manageable, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); heart muscle: 4.8 nTPM (vital, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 3); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); stomach: 3.1 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154655,L3MBTL4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.5455% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.9298% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.0625% (minimum 75%, Baseline (adaptation disabled)); liver: 59.1346% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.1290% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); skin: 63.7306% (minimum 65%, Baseline (adaptation disabled))",-0.0126943,-0.1,-0.158654,0,2,partial,8.5,8.2,7,"liver: 8.5 nTPM (vital, limit 1); parathyroid gland: 8.2 nTPM (protected, limit 3); skin: 7 nTPM (manageable, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 3); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); stomach: 3.1 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154655,L3MBTL4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.0422% (minimum 95%, Missing); adrenal gland: 64.0625% (minimum 99%, Missing); amygdala: 82.0000% (minimum 99%, Missing); basal ganglia: 79.6117% (minimum 99%, Missing); bone marrow: 24.4533% (minimum 99%, Missing); cerebellum: 65.4255% (minimum 99%, Missing); cerebral cortex: 66.3073% (minimum 99%, Missing); choroid plexus: 64.5669% (minimum 99%, Missing); colon: 70.0855% (minimum 97%, Missing); duodenum: 75.9259% (minimum 99%, Missing); esophagus: 56.1644% (minimum 97%, Missing); heart muscle: 71.9298% (minimum 99%, Missing); hippocampal formation: 80.6557% (minimum 99%, Missing); hypothalamus: 75.9259% (minimum 99%, Missing); kidney: 68.7151% (minimum 99%, Missing); liver: 62.7551% (minimum 99%, Missing); lung: 70.4871% (minimum 99%, Missing); lymph node: 68.3333% (minimum 97%, Missing); midbrain: 83.3898% (minimum 99%, Missing); pancreas: 72.3529% (minimum 99%, Missing); parathyroid gland: 63.0769% (minimum 97%, Missing); pituitary gland: 85.1211% (minimum 99%, Missing); rectum: 67.9558% (minimum 97%, Missing); retina: 33.6525% (minimum 99%, Missing); salivary gland: 74.3202% (minimum 97%, Missing); skeletal muscle: 65.7754% (minimum 99%, Missing); skin: 51.3570% (minimum 95%, Missing); small intestine: 73.2143% (minimum 99%, Missing); smooth muscle: 67.2131% (minimum 99%, Missing); spinal cord: 83.6735% (minimum 99%, Missing); spleen: 72.1408% (minimum 95%, Missing); stomach: 70.4871% (minimum 97%, Missing); thymus: 65.4255% (minimum 95%, Missing); thyroid gland: 61.1940% (minimum 95%, Missing); tongue: 65.6000% (minimum 97%, Missing); urinary bladder: 57.0766% (minimum 97%, Missing)",-0.43643,-0.408356,-0.745467,0,80,unavailable,76,19.2,23.3,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); skin: 23.3 nTPM (manageable, limit 5); esophagus: 19.2 nTPM (protected, limit 2); urinary bladder: 18.5 nTPM (protected, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 5); thyroid gland: 15.6 nTPM (manageable, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); thymus: 13 nTPM (manageable, limit 5); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 2); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 2); lymph node: 11.4 nTPM (protected, limit 2); kidney: 11.2 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 2); lung: 10.3 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 2); heart muscle: 9.6 nTPM (vital, limit 1); spleen: 9.5 nTPM (manageable, limit 5); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); salivary gland: 8.5 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154710,RABGEF1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.0422% (minimum 65%, Missing); adrenal gland: 64.0625% (minimum 75%, Missing); bone marrow: 24.4533% (minimum 75%, Missing); cerebellum: 65.4255% (minimum 75%, Missing); cerebral cortex: 66.3073% (minimum 75%, Missing); choroid plexus: 64.5669% (minimum 75%, Missing); esophagus: 56.1644% (minimum 70%, Missing); heart muscle: 71.9298% (minimum 75%, Missing); kidney: 68.7151% (minimum 75%, Missing); liver: 62.7551% (minimum 75%, Missing); lung: 70.4871% (minimum 75%, Missing); lymph node: 68.3333% (minimum 70%, Missing); pancreas: 72.3529% (minimum 75%, Missing); parathyroid gland: 63.0769% (minimum 70%, Missing); rectum: 67.9558% (minimum 70%, Missing); retina: 33.6525% (minimum 75%, Missing); skeletal muscle: 65.7754% (minimum 75%, Missing); skin: 51.3570% (minimum 65%, Missing); small intestine: 73.2143% (minimum 75%, Missing); smooth muscle: 67.2131% (minimum 75%, Missing); thyroid gland: 61.1940% (minimum 65%, Missing); tongue: 65.6000% (minimum 70%, Missing); urinary bladder: 57.0766% (minimum 70%, Missing)",-0.13643,-0.138356,-0.505467,0,80,unavailable,76,19.2,23.3,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); skin: 23.3 nTPM (manageable, limit 5); esophagus: 19.2 nTPM (protected, limit 2); urinary bladder: 18.5 nTPM (protected, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 5); thyroid gland: 15.6 nTPM (manageable, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); thymus: 13 nTPM (manageable, limit 5); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 2); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 2); lymph node: 11.4 nTPM (protected, limit 2); kidney: 11.2 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 2); lung: 10.3 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 2); heart muscle: 9.6 nTPM (vital, limit 1); spleen: 9.5 nTPM (manageable, limit 5); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); salivary gland: 8.5 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154710,RABGEF1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.0422% (minimum 65%, Missing); adrenal gland: 64.0625% (minimum 75%, Missing); bone marrow: 24.4533% (minimum 75%, Missing); cerebellum: 65.4255% (minimum 75%, Missing); cerebral cortex: 66.3073% (minimum 75%, Missing); choroid plexus: 64.5669% (minimum 75%, Missing); esophagus: 56.1644% (minimum 70%, Missing); heart muscle: 71.9298% (minimum 75%, Missing); kidney: 68.7151% (minimum 75%, Missing); liver: 62.7551% (minimum 75%, Missing); lung: 70.4871% (minimum 75%, Missing); lymph node: 68.3333% (minimum 70%, Missing); pancreas: 72.3529% (minimum 75%, Missing); parathyroid gland: 63.0769% (minimum 70%, Missing); rectum: 67.9558% (minimum 70%, Missing); retina: 33.6525% (minimum 75%, Missing); skeletal muscle: 65.7754% (minimum 75%, Missing); skin: 51.3570% (minimum 65%, Missing); small intestine: 73.2143% (minimum 75%, Missing); smooth muscle: 67.2131% (minimum 75%, Missing); thyroid gland: 61.1940% (minimum 65%, Missing); tongue: 65.6000% (minimum 70%, Missing); urinary bladder: 57.0766% (minimum 70%, Missing)",-0.13643,-0.138356,-0.505467,0,80,unavailable,76,19.2,23.3,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); skin: 23.3 nTPM (manageable, limit 5); esophagus: 19.2 nTPM (protected, limit 3); urinary bladder: 18.5 nTPM (protected, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 5); thyroid gland: 15.6 nTPM (manageable, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); thymus: 13 nTPM (manageable, limit 5); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 3); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 3); lymph node: 11.4 nTPM (protected, limit 3); kidney: 11.2 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 3); lung: 10.3 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); spleen: 9.5 nTPM (manageable, limit 5); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); salivary gland: 8.5 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154710,RABGEF1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.0422% (minimum 65%, Missing); adrenal gland: 64.0625% (minimum 75%, Missing); bone marrow: 24.4533% (minimum 75%, Missing); cerebellum: 65.4255% (minimum 75%, Missing); cerebral cortex: 66.3073% (minimum 75%, Missing); choroid plexus: 64.5669% (minimum 75%, Missing); esophagus: 56.1644% (minimum 70%, Missing); heart muscle: 71.9298% (minimum 75%, Missing); kidney: 68.7151% (minimum 75%, Missing); liver: 62.7551% (minimum 75%, Missing); lung: 70.4871% (minimum 75%, Missing); lymph node: 68.3333% (minimum 70%, Missing); pancreas: 72.3529% (minimum 75%, Missing); parathyroid gland: 63.0769% (minimum 70%, Missing); rectum: 67.9558% (minimum 70%, Missing); retina: 33.6525% (minimum 75%, Missing); skeletal muscle: 65.7754% (minimum 75%, Missing); skin: 51.3570% (minimum 65%, Missing); small intestine: 73.2143% (minimum 75%, Missing); smooth muscle: 67.2131% (minimum 75%, Missing); thyroid gland: 61.1940% (minimum 65%, Missing); tongue: 65.6000% (minimum 70%, Missing); urinary bladder: 57.0766% (minimum 70%, Missing)",-0.13643,-0.138356,-0.505467,0,80,unavailable,76,19.2,23.3,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); skin: 23.3 nTPM (manageable, limit 5); esophagus: 19.2 nTPM (protected, limit 3); urinary bladder: 18.5 nTPM (protected, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 5); thyroid gland: 15.6 nTPM (manageable, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); thymus: 13 nTPM (manageable, limit 5); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 3); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 3); lymph node: 11.4 nTPM (protected, limit 3); kidney: 11.2 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 3); lung: 10.3 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); spleen: 9.5 nTPM (manageable, limit 5); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); salivary gland: 8.5 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154710,RABGEF1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.0422% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 64.0625% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 24.4533% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.4255% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.3073% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.5669% (minimum 75%, Baseline (adaptation disabled)); esophagus: 56.1644% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 71.9298% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.7151% (minimum 75%, Baseline (adaptation disabled)); liver: 62.7551% (minimum 75%, Baseline (adaptation disabled)); lung: 70.4871% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.3333% (minimum 70%, Baseline (adaptation disabled)); pancreas: 72.3529% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.0769% (minimum 70%, Baseline (adaptation disabled)); rectum: 67.9558% (minimum 70%, Baseline (adaptation disabled)); retina: 33.6525% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 65.7754% (minimum 75%, Baseline (adaptation disabled)); skin: 51.3570% (minimum 65%, Baseline (adaptation disabled)); small intestine: 73.2143% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.2131% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 61.1940% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.6000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.0766% (minimum 70%, Baseline (adaptation disabled))",-0.13643,-0.138356,-0.505467,0,80,unavailable,76,19.2,23.3,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); skin: 23.3 nTPM (manageable, limit 5); esophagus: 19.2 nTPM (protected, limit 3); urinary bladder: 18.5 nTPM (protected, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 5); thyroid gland: 15.6 nTPM (manageable, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); thymus: 13 nTPM (manageable, limit 5); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 3); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 3); lymph node: 11.4 nTPM (protected, limit 3); kidney: 11.2 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 3); lung: 10.3 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); spleen: 9.5 nTPM (manageable, limit 5); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); salivary gland: 8.5 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154710,RABGEF1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1022% (minimum 95%, Missing); adrenal gland: 63.8814% (minimum 99%, Missing); amygdala: 79.2642% (minimum 99%, Missing); basal ganglia: 73.1481% (minimum 99%, Missing); bone marrow: 60.0000% (minimum 97%, Supported); cerebellum: 74.0625% (minimum 97%, Supported); cerebral cortex: 73.6025% (minimum 99%, Missing); choroid plexus: 89.4340% (minimum 99%, Missing); colon: 66.2011% (minimum 97%, Missing); duodenum: 65.2893% (minimum 99%, Missing); esophagus: 68.4971% (minimum 97%, Missing); heart muscle: 65.4696% (minimum 97%, Supported); hippocampal formation: 78.7375% (minimum 99%, Missing); hypothalamus: 81.7241% (minimum 99%, Missing); kidney: 64.0541% (minimum 99%, Missing); liver: 55.8962% (minimum 97%, Supported); lung: 64.7541% (minimum 99%, Missing); lymph node: 54.3578% (minimum 97%, Missing); midbrain: 77.7049% (minimum 99%, Missing); pancreas: 70.5357% (minimum 99%, Missing); parathyroid gland: 61.5584% (minimum 97%, Missing); pituitary gland: 78.4768% (minimum 99%, Missing); rectum: 64.0541% (minimum 97%, Missing); retina: 68.1034% (minimum 99%, Missing); salivary gland: 70.1183% (minimum 97%, Missing); skeletal muscle: 69.9115% (minimum 99%, Missing); skin: 70.3264% (minimum 95%, Missing); small intestine: 64.5777% (minimum 99%, Missing); smooth muscle: 61.5584% (minimum 99%, Missing); spinal cord: 73.1481% (minimum 99%, Missing); spleen: 56.5632% (minimum 95%, Missing); stomach: 67.3295% (minimum 97%, Missing); thymus: 52.4336% (minimum 95%, Missing); thyroid gland: 53.4989% (minimum 95%, Missing); tongue: 59.8485% (minimum 97%, Missing); urinary bladder: 65.4696% (minimum 97%, Missing)",-0.425664,-0.426422,-0.411038,0,2,partial,18.7,19.9,21.5,"thymus: 21.5 nTPM (manageable, limit 5); thyroid gland: 20.6 nTPM (manageable, limit 5); lymph node: 19.9 nTPM (protected, limit 2); liver: 18.7 nTPM (vital, limit 3); spleen: 18.2 nTPM (manageable, limit 5); adipose tissue: 16.4 nTPM (manageable, limit 5); tongue: 15.9 nTPM (protected, limit 2); bone marrow: 15.8 nTPM (vital, limit 3); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 2); adrenal gland: 13.4 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 2); kidney: 13.3 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 2); heart muscle: 12.5 nTPM (vital, limit 3); colon: 12.1 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 2); skeletal muscle: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); skin: 10 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 3); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154727,GABPA,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1022% (minimum 65%, Missing); adrenal gland: 63.8814% (minimum 75%, Missing); basal ganglia: 73.1481% (minimum 75%, Missing); bone marrow: 60.0000% (minimum 65%, Supported); cerebral cortex: 73.6025% (minimum 75%, Missing); colon: 66.2011% (minimum 70%, Missing); duodenum: 65.2893% (minimum 75%, Missing); esophagus: 68.4971% (minimum 70%, Missing); kidney: 64.0541% (minimum 75%, Missing); liver: 55.8962% (minimum 65%, Supported); lung: 64.7541% (minimum 75%, Missing); lymph node: 54.3578% (minimum 70%, Missing); pancreas: 70.5357% (minimum 75%, Missing); parathyroid gland: 61.5584% (minimum 70%, Missing); rectum: 64.0541% (minimum 70%, Missing); retina: 68.1034% (minimum 75%, Missing); skeletal muscle: 69.9115% (minimum 75%, Missing); small intestine: 64.5777% (minimum 75%, Missing); smooth muscle: 61.5584% (minimum 75%, Missing); spinal cord: 73.1481% (minimum 75%, Missing); spleen: 56.5632% (minimum 65%, Missing); stomach: 67.3295% (minimum 70%, Missing); thymus: 52.4336% (minimum 65%, Missing); thyroid gland: 53.4989% (minimum 65%, Missing); tongue: 59.8485% (minimum 70%, Missing); urinary bladder: 65.4696% (minimum 70%, Missing)",-0.125664,-0.156422,-0.134416,0,2,partial,18.7,19.9,21.5,"thymus: 21.5 nTPM (manageable, limit 5); thyroid gland: 20.6 nTPM (manageable, limit 5); lymph node: 19.9 nTPM (protected, limit 2); liver: 18.7 nTPM (vital, limit 3); spleen: 18.2 nTPM (manageable, limit 5); adipose tissue: 16.4 nTPM (manageable, limit 5); tongue: 15.9 nTPM (protected, limit 2); bone marrow: 15.8 nTPM (vital, limit 3); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 2); adrenal gland: 13.4 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 2); kidney: 13.3 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 2); heart muscle: 12.5 nTPM (vital, limit 3); colon: 12.1 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 2); skeletal muscle: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); skin: 10 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 3); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154727,GABPA,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1022% (minimum 65%, Missing); adrenal gland: 63.8814% (minimum 75%, Missing); basal ganglia: 73.1481% (minimum 75%, Missing); bone marrow: 60.0000% (minimum 65%, Supported); cerebral cortex: 73.6025% (minimum 75%, Missing); colon: 66.2011% (minimum 70%, Missing); duodenum: 65.2893% (minimum 75%, Missing); esophagus: 68.4971% (minimum 70%, Missing); kidney: 64.0541% (minimum 75%, Missing); liver: 55.8962% (minimum 65%, Supported); lung: 64.7541% (minimum 75%, Missing); lymph node: 54.3578% (minimum 70%, Missing); pancreas: 70.5357% (minimum 75%, Missing); parathyroid gland: 61.5584% (minimum 70%, Missing); rectum: 64.0541% (minimum 70%, Missing); retina: 68.1034% (minimum 75%, Missing); skeletal muscle: 69.9115% (minimum 75%, Missing); small intestine: 64.5777% (minimum 75%, Missing); smooth muscle: 61.5584% (minimum 75%, Missing); spinal cord: 73.1481% (minimum 75%, Missing); spleen: 56.5632% (minimum 65%, Missing); stomach: 67.3295% (minimum 70%, Missing); thymus: 52.4336% (minimum 65%, Missing); thyroid gland: 53.4989% (minimum 65%, Missing); tongue: 59.8485% (minimum 70%, Missing); urinary bladder: 65.4696% (minimum 70%, Missing)",-0.125664,-0.156422,-0.134416,0,2,partial,18.7,19.9,21.5,"thymus: 21.5 nTPM (manageable, limit 5); thyroid gland: 20.6 nTPM (manageable, limit 5); lymph node: 19.9 nTPM (protected, limit 3); liver: 18.7 nTPM (vital, limit 3); spleen: 18.2 nTPM (manageable, limit 5); adipose tissue: 16.4 nTPM (manageable, limit 5); tongue: 15.9 nTPM (protected, limit 3); bone marrow: 15.8 nTPM (vital, limit 3); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 3); adrenal gland: 13.4 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 3); kidney: 13.3 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 3); heart muscle: 12.5 nTPM (vital, limit 3); colon: 12.1 nTPM (protected, limit 3); stomach: 11.5 nTPM (protected, limit 3); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 3); skeletal muscle: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); skin: 10 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 3); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154727,GABPA,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1022% (minimum 65%, Missing); adrenal gland: 63.8814% (minimum 75%, Missing); basal ganglia: 73.1481% (minimum 75%, Missing); bone marrow: 60.0000% (minimum 65%, Supported); cerebral cortex: 73.6025% (minimum 75%, Missing); colon: 66.2011% (minimum 70%, Missing); duodenum: 65.2893% (minimum 75%, Missing); esophagus: 68.4971% (minimum 70%, Missing); kidney: 64.0541% (minimum 75%, Missing); liver: 55.8962% (minimum 65%, Supported); lung: 64.7541% (minimum 75%, Missing); lymph node: 54.3578% (minimum 70%, Missing); pancreas: 70.5357% (minimum 75%, Missing); parathyroid gland: 61.5584% (minimum 70%, Missing); rectum: 64.0541% (minimum 70%, Missing); retina: 68.1034% (minimum 75%, Missing); skeletal muscle: 69.9115% (minimum 75%, Missing); small intestine: 64.5777% (minimum 75%, Missing); smooth muscle: 61.5584% (minimum 75%, Missing); spinal cord: 73.1481% (minimum 75%, Missing); spleen: 56.5632% (minimum 65%, Missing); stomach: 67.3295% (minimum 70%, Missing); thymus: 52.4336% (minimum 65%, Missing); thyroid gland: 53.4989% (minimum 65%, Missing); tongue: 59.8485% (minimum 70%, Missing); urinary bladder: 65.4696% (minimum 70%, Missing)",-0.125664,-0.156422,-0.134416,0,2,partial,18.7,19.9,21.5,"thymus: 21.5 nTPM (manageable, limit 5); thyroid gland: 20.6 nTPM (manageable, limit 5); lymph node: 19.9 nTPM (protected, limit 3); liver: 18.7 nTPM (vital, limit 3); spleen: 18.2 nTPM (manageable, limit 5); adipose tissue: 16.4 nTPM (manageable, limit 5); tongue: 15.9 nTPM (protected, limit 3); bone marrow: 15.8 nTPM (vital, limit 3); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 3); adrenal gland: 13.4 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 3); kidney: 13.3 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 3); heart muscle: 12.5 nTPM (vital, limit 3); colon: 12.1 nTPM (protected, limit 3); stomach: 11.5 nTPM (protected, limit 3); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 3); skeletal muscle: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); skin: 10 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 3); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154727,GABPA,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1022% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.8814% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.1481% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 60.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.0625% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.6025% (minimum 75%, Baseline (adaptation disabled)); colon: 66.2011% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.2893% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.4971% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.4696% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.0541% (minimum 75%, Baseline (adaptation disabled)); liver: 55.8962% (minimum 75%, Baseline (adaptation disabled)); lung: 64.7541% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.3578% (minimum 70%, Baseline (adaptation disabled)); pancreas: 70.5357% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.5584% (minimum 70%, Baseline (adaptation disabled)); rectum: 64.0541% (minimum 70%, Baseline (adaptation disabled)); retina: 68.1034% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 69.9115% (minimum 75%, Baseline (adaptation disabled)); small intestine: 64.5777% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.5584% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.1481% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.5632% (minimum 65%, Baseline (adaptation disabled)); stomach: 67.3295% (minimum 70%, Baseline (adaptation disabled)); thymus: 52.4336% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.4989% (minimum 65%, Baseline (adaptation disabled)); tongue: 59.8485% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.4696% (minimum 70%, Baseline (adaptation disabled))",-0.125664,-0.156422,-0.191038,0,2,partial,18.7,19.9,21.5,"thymus: 21.5 nTPM (manageable, limit 5); thyroid gland: 20.6 nTPM (manageable, limit 5); lymph node: 19.9 nTPM (protected, limit 3); liver: 18.7 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); adipose tissue: 16.4 nTPM (manageable, limit 5); tongue: 15.9 nTPM (protected, limit 3); bone marrow: 15.8 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 3); adrenal gland: 13.4 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 3); kidney: 13.3 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 3); heart muscle: 12.5 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 3); stomach: 11.5 nTPM (protected, limit 3); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 3); skeletal muscle: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); skin: 10 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154727,GABPA,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 41.2698% (minimum 99%, Missing); basal ganglia: 44.8276% (minimum 99%, Missing); bone marrow: 96.2963% (minimum 98%, Approved); cerebellum: 83.8710% (minimum 98%, Approved); cerebral cortex: 39.3939% (minimum 98%, Approved); choroid plexus: 96.2963% (minimum 99%, Missing); esophagus: 86.6667% (minimum 95%, Approved); hippocampal formation: 61.9048% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 92.8571% (minimum 98%, Approved); lung: 56.5217% (minimum 98%, Approved); lymph node: 92.8571% (minimum 95%, Approved); midbrain: 63.4146% (minimum 99%, Missing); pancreas: 96.2963% (minimum 98%, Approved); skin: 74.2857% (minimum 90%, Approved); spinal cord: 74.2857% (minimum 99%, Missing); spleen: 68.4211% (minimum 90%, Approved); urinary bladder: 89.6552% (minimum 95%, Approved)",-0.215789,-0.0833333,-0.586061,0,1,partial,4,0.4,1.2,"cerebral cortex: 4 nTPM (vital, limit 2); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154764,WNT7A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 41.2698% (minimum 75%, Missing); basal ganglia: 44.8276% (minimum 75%, Missing); cerebral cortex: 39.3939% (minimum 70%, Approved); hippocampal formation: 61.9048% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); lung: 56.5217% (minimum 70%, Approved); midbrain: 63.4146% (minimum 75%, Missing); spinal cord: 74.2857% (minimum 75%, Missing)",0.0842105,0.216667,-0.337302,0,1,partial,4,0.4,1.2,"cerebral cortex: 4 nTPM (vital, limit 2); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154764,WNT7A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 41.2698% (minimum 75%, Missing); basal ganglia: 44.8276% (minimum 75%, Missing); cerebral cortex: 39.3939% (minimum 70%, Approved); hippocampal formation: 61.9048% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); lung: 56.5217% (minimum 70%, Approved); midbrain: 63.4146% (minimum 75%, Missing); spinal cord: 74.2857% (minimum 75%, Missing)",0.0842105,0.216667,-0.337302,0,1,partial,4,0.4,1.2,"cerebral cortex: 4 nTPM (vital, limit 2); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154764,WNT7A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 41.2698% (minimum 75%, Missing); basal ganglia: 44.8276% (minimum 75%, Missing); cerebral cortex: 39.3939% (minimum 70%, Approved); hippocampal formation: 61.9048% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); lung: 56.5217% (minimum 70%, Approved); midbrain: 63.4146% (minimum 75%, Missing); spinal cord: 74.2857% (minimum 75%, Missing)",0.0842105,0.216667,-0.337302,0,1,partial,4,0.4,1.2,"cerebral cortex: 4 nTPM (vital, limit 2); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154764,WNT7A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 41.2698% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 44.8276% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 39.3939% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.9048% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lung: 56.5217% (minimum 75%, Baseline (adaptation disabled)); midbrain: 63.4146% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.2857% (minimum 75%, Baseline (adaptation disabled))",0.0342105,0.166667,-0.356061,0,1,partial,4,0.4,1.2,"cerebral cortex: 4 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154764,WNT7A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.1111% (minimum 95%, Missing); adrenal gland: 89.1304% (minimum 99%, Missing); bone marrow: 25.7862% (minimum 99%, Missing); cerebellum: 85.4167% (minimum 99%, Missing); cerebral cortex: 93.1818% (minimum 99%, Missing); choroid plexus: 93.1818% (minimum 99%, Missing); colon: 71.9298% (minimum 97%, Missing); duodenum: 70.6897% (minimum 99%, Missing); esophagus: 62.1212% (minimum 97%, Missing); heart muscle: 95.3488% (minimum 99%, Missing); hypothalamus: 97.6190% (minimum 99%, Missing); kidney: 97.6190% (minimum 99%, Missing); liver: 93.1818% (minimum 99%, Missing); lung: 93.1818% (minimum 99%, Missing); lymph node: 46.5909% (minimum 97%, Missing); midbrain: 97.6190% (minimum 99%, Missing); pancreas: 91.1111% (minimum 99%, Missing); rectum: 67.2131% (minimum 97%, Missing); retina: 93.1818% (minimum 99%, Missing); salivary gland: 93.1818% (minimum 97%, Missing); skeletal muscle: 89.1304% (minimum 99%, Missing); skin: 73.2143% (minimum 95%, Missing); small intestine: 75.9259% (minimum 99%, Missing); smooth muscle: 78.8462% (minimum 99%, Missing); spinal cord: 97.6190% (minimum 99%, Missing); spleen: 75.9259% (minimum 90%, Approved); stomach: 83.6735% (minimum 97%, Missing); thymus: 53.9474% (minimum 95%, Missing); thyroid gland: 93.1818% (minimum 95%, Missing); tongue: 95.3488% (minimum 97%, Missing); urinary bladder: 89.1304% (minimum 97%, Missing)",-0.410526,-0.504091,-0.732138,0,3,partial,11.8,4.7,3.5,"bone marrow: 11.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154839,SKA1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.7862% (minimum 75%, Missing); duodenum: 70.6897% (minimum 75%, Missing); esophagus: 62.1212% (minimum 70%, Missing); lymph node: 46.5909% (minimum 70%, Missing); rectum: 67.2131% (minimum 70%, Missing); thymus: 53.9474% (minimum 65%, Missing)",-0.110526,-0.234091,-0.492138,0,3,partial,11.8,4.7,3.5,"bone marrow: 11.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154839,SKA1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.7862% (minimum 75%, Missing); duodenum: 70.6897% (minimum 75%, Missing); esophagus: 62.1212% (minimum 70%, Missing); lymph node: 46.5909% (minimum 70%, Missing); rectum: 67.2131% (minimum 70%, Missing); thymus: 53.9474% (minimum 65%, Missing)",-0.110526,-0.234091,-0.492138,0,3,partial,11.8,4.7,3.5,"bone marrow: 11.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154839,SKA1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.7862% (minimum 75%, Missing); duodenum: 70.6897% (minimum 75%, Missing); esophagus: 62.1212% (minimum 70%, Missing); lymph node: 46.5909% (minimum 70%, Missing); rectum: 67.2131% (minimum 70%, Missing); thymus: 53.9474% (minimum 65%, Missing)",-0.110526,-0.234091,-0.492138,0,3,partial,11.8,4.7,3.5,"bone marrow: 11.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154839,SKA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.7862% (minimum 75%, Baseline (adaptation disabled)); duodenum: 70.6897% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.1212% (minimum 70%, Baseline (adaptation disabled)); lymph node: 46.5909% (minimum 70%, Baseline (adaptation disabled)); rectum: 67.2131% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.9474% (minimum 65%, Baseline (adaptation disabled))",-0.110526,-0.234091,-0.492138,0,3,partial,11.8,4.7,3.5,"bone marrow: 11.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154839,SKA1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.5373% (minimum 95%, Missing); adrenal gland: 95.3846% (minimum 99%, Missing); amygdala: 96.8750% (minimum 99%, Missing); basal ganglia: 96.8750% (minimum 99%, Missing); bone marrow: 59.0476% (minimum 99%, Missing); cerebellum: 98.4127% (minimum 99%, Missing); cerebral cortex: 95.3846% (minimum 99%, Missing); colon: 87.3239% (minimum 97%, Missing); duodenum: 89.8551% (minimum 99%, Missing); esophagus: 86.1111% (minimum 97%, Missing); heart muscle: 96.8750% (minimum 99%, Missing); hippocampal formation: 95.3846% (minimum 99%, Missing); hypothalamus: 98.4127% (minimum 99%, Missing); kidney: 96.8750% (minimum 99%, Missing); liver: 93.9394% (minimum 99%, Missing); lung: 93.9394% (minimum 99%, Missing); lymph node: 73.8095% (minimum 97%, Missing); midbrain: 96.8750% (minimum 99%, Missing); pancreas: 96.8750% (minimum 99%, Missing); pituitary gland: 98.4127% (minimum 99%, Missing); rectum: 83.7838% (minimum 97%, Missing); retina: 93.9394% (minimum 99%, Missing); salivary gland: 93.9394% (minimum 97%, Missing); skeletal muscle: 96.8750% (minimum 99%, Missing); skin: 86.1111% (minimum 95%, Missing); small intestine: 89.8551% (minimum 99%, Missing); smooth muscle: 91.1765% (minimum 99%, Missing); spinal cord: 95.3846% (minimum 99%, Missing); spleen: 87.3239% (minimum 95%, Missing); stomach: 93.9394% (minimum 97%, Missing); thymus: 65.9574% (minimum 95%, Missing); urinary bladder: 93.9394% (minimum 97%, Missing)",-0.290426,-0.231905,-0.399524,0,2,partial,4.3,2.2,3.2,"bone marrow: 4.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154920,EME1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 59.0476% (minimum 75%, Missing)",0.00957447,0.0380952,-0.159524,0,2,partial,4.3,2.2,3.2,"bone marrow: 4.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154920,EME1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 59.0476% (minimum 75%, Missing)",0.00957447,0.0380952,-0.159524,0,2,partial,4.3,2.2,3.2,"bone marrow: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154920,EME1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 59.0476% (minimum 75%, Missing)",0.00957447,0.0380952,-0.159524,0,2,partial,4.3,2.2,3.2,"bone marrow: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154920,EME1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 59.0476% (minimum 75%, Baseline (adaptation disabled))",0.00957447,0.0380952,-0.159524,0,2,partial,4.3,2.2,3.2,"bone marrow: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154920,EME1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.7571% (minimum 99%, Missing); basal ganglia: 41.2698% (minimum 99%, Missing); bone marrow: 94.5455% (minimum 95%, Enhanced); cerebellum: 33.9869% (minimum 99%, Missing); cerebral cortex: 43.5146% (minimum 95%, Enhanced); choroid plexus: 97.1963% (minimum 99%, Missing); colon: 77.0370% (minimum 97%, Missing); duodenum: 88.8889% (minimum 95%, Enhanced); hippocampal formation: 67.0968% (minimum 99%, Missing); hypothalamus: 72.7273% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 87.3950% (minimum 95%, Enhanced); midbrain: 87.3950% (minimum 99%, Missing); pituitary gland: 92.0354% (minimum 99%, Missing); retina: 72.2222% (minimum 99%, Missing); skeletal muscle: 68.8742% (minimum 95%, Enhanced); small intestine: 93.6937% (minimum 95%, Enhanced); smooth muscle: 93.6937% (minimum 95%, Enhanced); spinal cord: 88.1356% (minimum 99%, Missing); stomach: 94.5455% (minimum 97%, Missing); thymus: 94.5455% (minimum 95%, Missing); thyroid gland: 60.4651% (minimum 95%, Missing); tongue: 51.2315% (minimum 97%, Missing); urinary bladder: 88.1356% (minimum 97%, Missing)",-0.345349,-0.457685,-0.650131,0,9,partial,20.2,9.9,6.8,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 6); tongue: 9.9 nTPM (protected, limit 2); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154928,EPHB1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.7571% (minimum 75%, Missing); basal ganglia: 41.2698% (minimum 75%, Missing); cerebellum: 33.9869% (minimum 75%, Missing); cerebral cortex: 43.5146% (minimum 60%, Enhanced); hippocampal formation: 67.0968% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); retina: 72.2222% (minimum 75%, Missing); thyroid gland: 60.4651% (minimum 65%, Missing); tongue: 51.2315% (minimum 70%, Missing)",-0.0453488,-0.187685,-0.410131,0,9,partial,20.2,9.9,6.8,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 6); tongue: 9.9 nTPM (protected, limit 2); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154928,EPHB1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.7571% (minimum 75%, Missing); basal ganglia: 41.2698% (minimum 75%, Missing); cerebellum: 33.9869% (minimum 75%, Missing); cerebral cortex: 43.5146% (minimum 60%, Enhanced); hippocampal formation: 67.0968% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); retina: 72.2222% (minimum 75%, Missing); thyroid gland: 60.4651% (minimum 65%, Missing); tongue: 51.2315% (minimum 70%, Missing)",-0.0453488,-0.187685,-0.410131,0,9,partial,20.2,9.9,6.8,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 6); tongue: 9.9 nTPM (protected, limit 3); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154928,EPHB1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.7571% (minimum 75%, Missing); basal ganglia: 41.2698% (minimum 75%, Missing); cerebellum: 33.9869% (minimum 75%, Missing); cerebral cortex: 43.5146% (minimum 60%, Enhanced); hippocampal formation: 67.0968% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); retina: 72.2222% (minimum 75%, Missing); thyroid gland: 60.4651% (minimum 65%, Missing); tongue: 51.2315% (minimum 70%, Missing)",-0.0453488,-0.187685,-0.410131,0,9,partial,20.2,9.9,6.8,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 6); tongue: 9.9 nTPM (protected, limit 3); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154928,EPHB1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.7571% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 41.2698% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 33.9869% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 43.5146% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.0968% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.7273% (minimum 75%, Baseline (adaptation disabled)); retina: 72.2222% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 68.8742% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 60.4651% (minimum 65%, Baseline (adaptation disabled)); tongue: 51.2315% (minimum 70%, Baseline (adaptation disabled))",-0.0453488,-0.187685,-0.410131,0,9,partial,20.2,9.9,6.8,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 3); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); liver: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154928,EPHB1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.5350% (minimum 95%, Enhanced); choroid plexus: 98.6547% (minimum 99%, Missing); liver: 90.9091% (minimum 95%, Enhanced); pituitary gland: 94.4206% (minimum 99%, Missing); retina: 91.6667% (minimum 99%, Missing); thymus: 94.8276% (minimum 95%, Missing)",-0.00172414,0.00777778,-0.0733333,0,3,partial,2.3,1.1,1.4,"retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154997,SEPTIN14,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.298276,0.277778,0.166667,0,3,partial,2.3,1.1,1.4,"retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154997,SEPTIN14,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.298276,0.277778,0.166667,0,3,partial,2.3,1.1,1.4,"retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154997,SEPTIN14,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.298276,0.277778,0.166667,0,3,partial,2.3,1.1,1.4,"retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154997,SEPTIN14,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.290171,0.252381,0.15535,0,3,partial,2.3,1.1,1.4,"bone marrow: 2.3 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000154997,SEPTIN14,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 94.5813% (minimum 99%, Missing); basal ganglia: 93.2039% (minimum 99%, Missing); choroid plexus: 82.0513% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); lung: 93.2039% (minimum 97%, Supported); midbrain: 97.9592% (minimum 99%, Missing); pituitary gland: 94.5813% (minimum 99%, Missing); retina: 98.4615% (minimum 99%, Missing); spinal cord: 97.4619% (minimum 99%, Missing)",0.05,0.0248187,-0.169487,0,4,partial,4.2,0.9,1,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155026,RSPH10B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.294819,0.0705128,0,4,partial,4.2,0.9,1,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155026,RSPH10B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.294819,0.0705128,0,4,partial,4.2,0.9,1,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155026,RSPH10B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.294819,0.0705128,0,4,partial,4.2,0.9,1,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155026,RSPH10B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.300495,0.255224,0.0705128,0,4,partial,4.2,0.9,1,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155026,RSPH10B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.5641% (minimum 95%, Missing); adrenal gland: 84.2932% (minimum 99%, Missing); amygdala: 77.0335% (minimum 99%, Missing); basal ganglia: 75.5869% (minimum 99%, Missing); bone marrow: 81.3131% (minimum 99%, Missing); cerebellum: 73.8532% (minimum 99%, Missing); cerebral cortex: 76.6667% (minimum 99%, Missing); choroid plexus: 50.9494% (minimum 99%, Missing); colon: 78.5366% (minimum 97%, Missing); duodenum: 82.1429% (minimum 99%, Missing); esophagus: 79.7030% (minimum 97%, Missing); heart muscle: 77.4038% (minimum 99%, Missing); hippocampal formation: 73.8532% (minimum 99%, Missing); hypothalamus: 70.6140% (minimum 99%, Missing); kidney: 75.9434% (minimum 99%, Missing); liver: 84.2932% (minimum 99%, Missing); lung: 80.0995% (minimum 99%, Missing); lymph node: 80.0995% (minimum 97%, Missing); midbrain: 72.1973% (minimum 99%, Missing); pancreas: 82.9897% (minimum 99%, Missing); parathyroid gland: 64.6586% (minimum 97%, Missing); pituitary gland: 68.2203% (minimum 99%, Missing); rectum: 79.3103% (minimum 97%, Missing); retina: 54.2088% (minimum 99%, Missing); salivary gland: 76.3033% (minimum 97%, Missing); skeletal muscle: 77.7778% (minimum 99%, Missing); skin: 80.9045% (minimum 95%, Missing); small intestine: 82.5641% (minimum 99%, Missing); smooth muscle: 81.3131% (minimum 99%, Missing); spinal cord: 68.5106% (minimum 99%, Missing); spleen: 80.5000% (minimum 95%, Missing); stomach: 78.5366% (minimum 97%, Missing); thymus: 68.8034% (minimum 95%, Missing); thyroid gland: 70.9251% (minimum 95%, Missing); tongue: 82.5641% (minimum 97%, Missing); urinary bladder: 82.9897% (minimum 97%, Missing)",-0.261966,-0.323414,-0.480506,0,2,partial,15.5,8.8,7.3,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 2); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); colon: 4.4 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); lymph node: 4 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); urinary bladder: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155085,AK9,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 73.8532% (minimum 75%, Missing); choroid plexus: 50.9494% (minimum 75%, Missing); hippocampal formation: 73.8532% (minimum 75%, Missing); hypothalamus: 70.6140% (minimum 75%, Missing); midbrain: 72.1973% (minimum 75%, Missing); parathyroid gland: 64.6586% (minimum 70%, Missing); pituitary gland: 68.2203% (minimum 75%, Missing); retina: 54.2088% (minimum 75%, Missing); spinal cord: 68.5106% (minimum 75%, Missing)",0.0380342,-0.0534137,-0.240506,0,2,partial,15.5,8.8,7.3,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 2); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); colon: 4.4 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); lymph node: 4 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); urinary bladder: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155085,AK9,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 73.8532% (minimum 75%, Missing); choroid plexus: 50.9494% (minimum 75%, Missing); hippocampal formation: 73.8532% (minimum 75%, Missing); hypothalamus: 70.6140% (minimum 75%, Missing); midbrain: 72.1973% (minimum 75%, Missing); parathyroid gland: 64.6586% (minimum 70%, Missing); pituitary gland: 68.2203% (minimum 75%, Missing); retina: 54.2088% (minimum 75%, Missing); spinal cord: 68.5106% (minimum 75%, Missing)",0.0380342,-0.0534137,-0.240506,0,2,partial,15.5,8.8,7.3,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 3); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); colon: 4.4 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); lymph node: 4 nTPM (protected, limit 3); lung: 4 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); urinary bladder: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155085,AK9,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 73.8532% (minimum 75%, Missing); choroid plexus: 50.9494% (minimum 75%, Missing); hippocampal formation: 73.8532% (minimum 75%, Missing); hypothalamus: 70.6140% (minimum 75%, Missing); midbrain: 72.1973% (minimum 75%, Missing); parathyroid gland: 64.6586% (minimum 70%, Missing); pituitary gland: 68.2203% (minimum 75%, Missing); retina: 54.2088% (minimum 75%, Missing); spinal cord: 68.5106% (minimum 75%, Missing)",0.0380342,-0.0534137,-0.240506,0,2,partial,15.5,8.8,7.3,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 3); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); colon: 4.4 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); lymph node: 4 nTPM (protected, limit 3); lung: 4 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); urinary bladder: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155085,AK9,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 73.8532% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 50.9494% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.8532% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 70.6140% (minimum 75%, Baseline (adaptation disabled)); midbrain: 72.1973% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.6586% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 68.2203% (minimum 75%, Baseline (adaptation disabled)); retina: 54.2088% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.5106% (minimum 75%, Baseline (adaptation disabled))",0.0380342,-0.0534137,-0.240506,0,2,partial,15.5,8.8,7.3,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 3); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); colon: 4.4 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); lymph node: 4 nTPM (protected, limit 3); lung: 4 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); urinary bladder: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155085,AK9,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.00818981,0,1,partial,0.7,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155087,ODF1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.24819,0,1,partial,0.7,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155087,ODF1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.24819,0,1,partial,0.7,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155087,ODF1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.24819,0,1,partial,0.7,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155087,ODF1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.349741,0.299741,0.24819,0,1,partial,0.7,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155087,ODF1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000155249,OR4K1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000155249,OR4K1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000155249,OR4K1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000155249,OR4K1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000155249,OR4K1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.0934% (minimum 95%, Missing); adrenal gland: 80.7692% (minimum 99%, Missing); amygdala: 80.3982% (minimum 99%, Missing); basal ganglia: 77.4336% (minimum 99%, Missing); bone marrow: 66.2043% (minimum 99%, Missing); cerebellum: 88.2353% (minimum 99%, Missing); cerebral cortex: 78.3582% (minimum 99%, Missing); choroid plexus: 85.0891% (minimum 99%, Missing); colon: 78.0089% (minimum 97%, Missing); duodenum: 81.0185% (minimum 99%, Missing); esophagus: 71.4286% (minimum 97%, Missing); heart muscle: 65.8720% (minimum 99%, Missing); hippocampal formation: 80.1527% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); kidney: 71.9178% (minimum 99%, Missing); liver: 73.0181% (minimum 99%, Missing); lung: 69.5364% (minimum 99%, Missing); lymph node: 72.8155% (minimum 97%, Missing); midbrain: 85.9247% (minimum 99%, Missing); pancreas: 77.3196% (minimum 99%, Missing); parathyroid gland: 79.3051% (minimum 97%, Missing); pituitary gland: 87.6461% (minimum 99%, Missing); rectum: 77.0925% (minimum 97%, Missing); retina: 84.9515% (minimum 99%, Missing); salivary gland: 75.7576% (minimum 97%, Missing); skeletal muscle: 31.1019% (minimum 99%, Missing); skin: 80.6452% (minimum 95%, Missing); small intestine: 80.1527% (minimum 99%, Missing); smooth muscle: 59.8632% (minimum 99%, Missing); spinal cord: 84.6774% (minimum 99%, Missing); spleen: 73.8397% (minimum 95%, Missing); stomach: 80.5215% (minimum 97%, Missing); thymus: 67.8295% (minimum 95%, Missing); thyroid gland: 77.7778% (minimum 95%, Missing); tongue: 41.9329% (minimum 97%, Missing); urinary bladder: 77.8932% (minimum 97%, Missing)",-0.271705,-0.550671,-0.678981,0,0,routine_complete,116.3,72.7,24.9,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 2); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); thymus: 24.9 nTPM (manageable, limit 5); adipose tissue: 24.6 nTPM (manageable, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 2); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 2); liver: 19.4 nTPM (vital, limit 1); spleen: 18.6 nTPM (manageable, limit 5); salivary gland: 16.8 nTPM (protected, limit 2); rectum: 15.6 nTPM (protected, limit 2); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); urinary bladder: 14.9 nTPM (protected, limit 2); colon: 14.8 nTPM (protected, limit 2); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 2); small intestine: 13 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); skin: 12.6 nTPM (manageable, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155313,USP25,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.2043% (minimum 75%, Missing); heart muscle: 65.8720% (minimum 75%, Missing); kidney: 71.9178% (minimum 75%, Missing); liver: 73.0181% (minimum 75%, Missing); lung: 69.5364% (minimum 75%, Missing); skeletal muscle: 31.1019% (minimum 75%, Missing); smooth muscle: 59.8632% (minimum 75%, Missing); tongue: 41.9329% (minimum 70%, Missing)",0.0282946,-0.280671,-0.438981,0,0,routine_complete,116.3,72.7,24.9,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 2); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); thymus: 24.9 nTPM (manageable, limit 5); adipose tissue: 24.6 nTPM (manageable, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 2); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 2); liver: 19.4 nTPM (vital, limit 1); spleen: 18.6 nTPM (manageable, limit 5); salivary gland: 16.8 nTPM (protected, limit 2); rectum: 15.6 nTPM (protected, limit 2); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); urinary bladder: 14.9 nTPM (protected, limit 2); colon: 14.8 nTPM (protected, limit 2); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 2); small intestine: 13 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); skin: 12.6 nTPM (manageable, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155313,USP25,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.2043% (minimum 75%, Missing); heart muscle: 65.8720% (minimum 75%, Missing); kidney: 71.9178% (minimum 75%, Missing); liver: 73.0181% (minimum 75%, Missing); lung: 69.5364% (minimum 75%, Missing); skeletal muscle: 31.1019% (minimum 75%, Missing); smooth muscle: 59.8632% (minimum 75%, Missing); tongue: 41.9329% (minimum 70%, Missing)",0.0282946,-0.280671,-0.438981,0,0,routine_complete,116.3,72.7,24.9,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 3); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); thymus: 24.9 nTPM (manageable, limit 5); adipose tissue: 24.6 nTPM (manageable, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 3); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 3); liver: 19.4 nTPM (vital, limit 1); spleen: 18.6 nTPM (manageable, limit 5); salivary gland: 16.8 nTPM (protected, limit 3); rectum: 15.6 nTPM (protected, limit 3); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); urinary bladder: 14.9 nTPM (protected, limit 3); colon: 14.8 nTPM (protected, limit 3); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 3); small intestine: 13 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 3); skin: 12.6 nTPM (manageable, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155313,USP25,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.2043% (minimum 75%, Missing); heart muscle: 65.8720% (minimum 75%, Missing); kidney: 71.9178% (minimum 75%, Missing); liver: 73.0181% (minimum 75%, Missing); lung: 69.5364% (minimum 75%, Missing); skeletal muscle: 31.1019% (minimum 75%, Missing); smooth muscle: 59.8632% (minimum 75%, Missing); tongue: 41.9329% (minimum 70%, Missing)",0.0282946,-0.280671,-0.438981,0,0,routine_complete,116.3,72.7,24.9,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 3); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); thymus: 24.9 nTPM (manageable, limit 5); adipose tissue: 24.6 nTPM (manageable, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 3); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 3); liver: 19.4 nTPM (vital, limit 1); spleen: 18.6 nTPM (manageable, limit 5); salivary gland: 16.8 nTPM (protected, limit 3); rectum: 15.6 nTPM (protected, limit 3); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); urinary bladder: 14.9 nTPM (protected, limit 3); colon: 14.8 nTPM (protected, limit 3); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 3); small intestine: 13 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 3); skin: 12.6 nTPM (manageable, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155313,USP25,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.2043% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 65.8720% (minimum 75%, Baseline (adaptation disabled)); kidney: 71.9178% (minimum 75%, Baseline (adaptation disabled)); liver: 73.0181% (minimum 75%, Baseline (adaptation disabled)); lung: 69.5364% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 31.1019% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.8632% (minimum 75%, Baseline (adaptation disabled)); tongue: 41.9329% (minimum 70%, Baseline (adaptation disabled))",0.0282946,-0.280671,-0.438981,0,0,routine_complete,116.3,72.7,24.9,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 3); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); thymus: 24.9 nTPM (manageable, limit 5); adipose tissue: 24.6 nTPM (manageable, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 3); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 3); liver: 19.4 nTPM (vital, limit 1); spleen: 18.6 nTPM (manageable, limit 5); salivary gland: 16.8 nTPM (protected, limit 3); rectum: 15.6 nTPM (protected, limit 3); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); urinary bladder: 14.9 nTPM (protected, limit 3); colon: 14.8 nTPM (protected, limit 3); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 3); small intestine: 13 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 3); skin: 12.6 nTPM (manageable, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155313,USP25,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.1776% (minimum 95%, Uncertain); adrenal gland: 79.4643% (minimum 99%, Uncertain); amygdala: 81.6514% (minimum 99%, Missing); basal ganglia: 75.4237% (minimum 99%, Missing); bone marrow: 60.5442% (minimum 99%, Uncertain); cerebellum: 83.9623% (minimum 99%, Missing); cerebral cortex: 75.7447% (minimum 99%, Missing); choroid plexus: 86.4078% (minimum 99%, Missing); colon: 82.0276% (minimum 97%, Uncertain); duodenum: 87.2549% (minimum 99%, Uncertain); esophagus: 79.8206% (minimum 97%, Missing); heart muscle: 74.7899% (minimum 99%, Missing); hippocampal formation: 81.6514% (minimum 99%, Missing); hypothalamus: 83.5681% (minimum 99%, Missing); kidney: 70.9163% (minimum 99%, Missing); liver: 58.3607% (minimum 99%, Uncertain); lung: 82.0276% (minimum 99%, Uncertain); lymph node: 75.1055% (minimum 97%, Uncertain); midbrain: 85.5769% (minimum 99%, Missing); pancreas: 88.1188% (minimum 99%, Uncertain); parathyroid gland: 77.7293% (minimum 97%, Uncertain); pituitary gland: 82.4074% (minimum 99%, Missing); rectum: 89.0000% (minimum 97%, Missing); retina: 88.5572% (minimum 99%, Missing); salivary gland: 84.7619% (minimum 97%, Uncertain); skeletal muscle: 57.4194% (minimum 99%, Missing); skin: 83.1776% (minimum 95%, Missing); small intestine: 79.4643% (minimum 99%, Uncertain); smooth muscle: 86.8293% (minimum 99%, Uncertain); spinal cord: 84.7619% (minimum 99%, Missing); spleen: 82.4074% (minimum 95%, Uncertain); stomach: 86.4078% (minimum 97%, Missing); thymus: 83.1776% (minimum 95%, Missing); thyroid gland: 86.4078% (minimum 95%, Uncertain); tongue: 71.2000% (minimum 97%, Missing); urinary bladder: 81.6514% (minimum 97%, Missing)",-0.125926,-0.258,-0.415806,0,1,partial,13.2,7.2,3.8,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 2); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 2); adrenal gland: 4.6 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); hippocampal formation: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155330,C16orf87,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 60.5442% (minimum 75%, Uncertain); heart muscle: 74.7899% (minimum 75%, Missing); kidney: 70.9163% (minimum 75%, Missing); liver: 58.3607% (minimum 75%, Uncertain); skeletal muscle: 57.4194% (minimum 75%, Missing)",0.174074,0.012,-0.175806,0,1,partial,13.2,7.2,3.8,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 2); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 2); adrenal gland: 4.6 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); hippocampal formation: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155330,C16orf87,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 60.5442% (minimum 75%, Uncertain); heart muscle: 74.7899% (minimum 75%, Missing); kidney: 70.9163% (minimum 75%, Missing); liver: 58.3607% (minimum 75%, Uncertain); skeletal muscle: 57.4194% (minimum 75%, Missing)",0.174074,0.012,-0.175806,0,1,partial,13.2,7.2,3.8,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 3); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 3); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 3); small intestine: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); urinary bladder: 4 nTPM (protected, limit 3); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 3); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155330,C16orf87,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 60.5442% (minimum 75%, Uncertain); heart muscle: 74.7899% (minimum 75%, Missing); kidney: 70.9163% (minimum 75%, Missing); liver: 58.3607% (minimum 75%, Uncertain); skeletal muscle: 57.4194% (minimum 75%, Missing)",0.174074,0.012,-0.175806,0,1,partial,13.2,7.2,3.8,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 3); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 3); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 3); small intestine: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); urinary bladder: 4 nTPM (protected, limit 3); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 3); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155330,C16orf87,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 60.5442% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 74.7899% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.9163% (minimum 75%, Baseline (adaptation disabled)); liver: 58.3607% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 57.4194% (minimum 75%, Baseline (adaptation disabled))",0.174074,0.012,-0.175806,0,1,partial,13.2,7.2,3.8,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 3); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 3); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 3); small intestine: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); urinary bladder: 4 nTPM (protected, limit 3); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 3); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155330,C16orf87,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.8269% (minimum 99%, Missing); amygdala: 88.8252% (minimum 99%, Missing); basal ganglia: 93.3735% (minimum 99%, Missing); bone marrow: 98.7261% (minimum 99%, Uncertain); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 88.5714% (minimum 99%, Missing); choroid plexus: 94.6565% (minimum 99%, Missing); duodenum: 98.8836% (minimum 99%, Missing); esophagus: 93.3735% (minimum 97%, Missing); heart muscle: 88.0682% (minimum 99%, Missing); hippocampal formation: 92.3994% (minimum 99%, Missing); hypothalamus: 91.0426% (minimum 99%, Missing); kidney: 89.2086% (minimum 99%, Missing); liver: 98.8836% (minimum 99%, Uncertain); lung: 97.6378% (minimum 99%, Missing); lymph node: 94.6565% (minimum 97%, Missing); midbrain: 92.9535% (minimum 99%, Missing); pancreas: 97.4843% (minimum 99%, Missing); parathyroid gland: 91.3108% (minimum 97%, Missing); pituitary gland: 96.1240% (minimum 99%, Missing); retina: 89.3372% (minimum 99%, Missing); salivary gland: 95.8269% (minimum 97%, Missing); skeletal muscle: 45.8919% (minimum 99%, Missing); skin: 76.1671% (minimum 95%, Missing); small intestine: 97.7918% (minimum 99%, Missing); smooth muscle: 97.7918% (minimum 99%, Uncertain); spinal cord: 97.1787% (minimum 99%, Missing); tongue: 69.5847% (minimum 97%, Missing)",-0.188329,-0.274153,-0.531081,0,6,partial,73.1,27.1,19.4,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 2); skin: 19.4 nTPM (manageable, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155367,PPM1J,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skeletal muscle: 45.8919% (minimum 75%, Missing); tongue: 69.5847% (minimum 70%, Missing)",0.111671,-0.00415264,-0.291081,0,6,partial,73.1,27.1,19.4,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 2); skin: 19.4 nTPM (manageable, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155367,PPM1J,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skeletal muscle: 45.8919% (minimum 75%, Missing); tongue: 69.5847% (minimum 70%, Missing)",0.111671,-0.00415264,-0.291081,0,6,partial,73.1,27.1,19.4,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 3); skin: 19.4 nTPM (manageable, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 3); lymph node: 3.5 nTPM (protected, limit 3); choroid plexus: 3.5 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155367,PPM1J,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skeletal muscle: 45.8919% (minimum 75%, Missing); tongue: 69.5847% (minimum 70%, Missing)",0.111671,-0.00415264,-0.291081,0,6,partial,73.1,27.1,19.4,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 3); skin: 19.4 nTPM (manageable, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 3); lymph node: 3.5 nTPM (protected, limit 3); choroid plexus: 3.5 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155367,PPM1J,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skeletal muscle: 45.8919% (minimum 75%, Baseline (adaptation disabled)); tongue: 69.5847% (minimum 70%, Baseline (adaptation disabled))",0.111671,-0.00415264,-0.291081,0,6,partial,73.1,27.1,19.4,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 3); skin: 19.4 nTPM (manageable, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 3); lymph node: 3.5 nTPM (protected, limit 3); choroid plexus: 3.5 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155367,PPM1J,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155495,MAGEC1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155495,MAGEC1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155495,MAGEC1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155495,MAGEC1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.336111,0.3,0.25,0,1,partial,0,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155495,MAGEC1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.1538% (minimum 99%, Missing); amygdala: 96.1538% (minimum 99%, Missing); basal ganglia: 92.5926% (minimum 99%, Missing); bone marrow: 89.2857% (minimum 99%, Missing); cerebellum: 98.0392% (minimum 99%, Missing); cerebral cortex: 98.0392% (minimum 99%, Missing); choroid plexus: 60.9756% (minimum 99%, Missing); colon: 96.1538% (minimum 97%, Missing); duodenum: 98.0392% (minimum 99%, Missing); heart muscle: 98.0392% (minimum 99%, Missing); hippocampal formation: 92.5926% (minimum 99%, Missing); hypothalamus: 92.5926% (minimum 99%, Missing); kidney: 90.9091% (minimum 99%, Missing); liver: 92.5926% (minimum 99%, Missing); lung: 90.9091% (minimum 99%, Missing); midbrain: 98.0392% (minimum 99%, Missing); pancreas: 86.2069% (minimum 99%, Missing); parathyroid gland: 96.1538% (minimum 97%, Missing); pituitary gland: 87.7193% (minimum 99%, Missing); rectum: 96.1538% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 90.9091% (minimum 97%, Missing); skin: 90.9091% (minimum 95%, Missing); small intestine: 96.1538% (minimum 99%, Missing); smooth muscle: 96.1538% (minimum 99%, Missing); spinal cord: 98.0392% (minimum 99%, Missing); spleen: 90.9091% (minimum 95%, Missing); stomach: 96.1538% (minimum 97%, Missing); thyroid gland: 90.9091% (minimum 95%, Missing)",-0.0409091,-0.0609091,-0.380244,0,80,unavailable,3.2,0.5,0.5,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155530,LRGUK,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 60.9756% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.259091,0.209091,-0.140244,0,80,unavailable,3.2,0.5,0.5,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155530,LRGUK,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 60.9756% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.259091,0.209091,-0.140244,0,80,unavailable,3.2,0.5,0.5,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155530,LRGUK,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 60.9756% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.259091,0.209091,-0.140244,0,80,unavailable,3.2,0.5,0.5,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155530,LRGUK,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 60.9756% (minimum 75%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.259091,0.209091,-0.140244,0,80,unavailable,3.2,0.5,0.5,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155530,LRGUK,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Missing); adrenal gland: 75.4717% (minimum 99%, Missing); amygdala: 71.4286% (minimum 99%, Missing); basal ganglia: 72.7273% (minimum 99%, Missing); bone marrow: 68.9655% (minimum 99%, Missing); cerebellum: 68.9655% (minimum 99%, Missing); cerebral cortex: 64.5161% (minimum 99%, Missing); choroid plexus: 85.1064% (minimum 99%, Missing); colon: 75.4717% (minimum 97%, Missing); duodenum: 86.9565% (minimum 99%, Missing); esophagus: 86.9565% (minimum 97%, Missing); heart muscle: 68.9655% (minimum 99%, Missing); hippocampal formation: 71.4286% (minimum 99%, Missing); hypothalamus: 67.7966% (minimum 99%, Missing); kidney: 72.7273% (minimum 99%, Missing); liver: 71.4286% (minimum 99%, Missing); lung: 78.4314% (minimum 99%, Missing); lymph node: 76.9231% (minimum 97%, Missing); midbrain: 72.7273% (minimum 99%, Missing); pancreas: 80.0000% (minimum 99%, Missing); parathyroid gland: 58.8235% (minimum 97%, Missing); pituitary gland: 71.4286% (minimum 99%, Missing); rectum: 81.6327% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 78.4314% (minimum 97%, Missing); skeletal muscle: 56.3380% (minimum 99%, Missing); skin: 86.9565% (minimum 95%, Missing); small intestine: 81.6327% (minimum 99%, Missing); smooth muscle: 68.9655% (minimum 99%, Missing); spinal cord: 71.4286% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 78.4314% (minimum 97%, Missing); thymus: 63.4921% (minimum 95%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); tongue: 47.6190% (minimum 97%, Missing); urinary bladder: 78.4314% (minimum 97%, Missing)",-0.315079,-0.49381,-0.49,0,80,unavailable,4,4.4,2.3,"tongue: 4.4 nTPM (protected, limit 2); retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155592,ZKSCAN2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 72.7273% (minimum 75%, Missing); bone marrow: 68.9655% (minimum 75%, Missing); cerebellum: 68.9655% (minimum 75%, Missing); cerebral cortex: 64.5161% (minimum 75%, Missing); heart muscle: 68.9655% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 67.7966% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); midbrain: 72.7273% (minimum 75%, Missing); parathyroid gland: 58.8235% (minimum 70%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); skeletal muscle: 56.3380% (minimum 75%, Missing); smooth muscle: 68.9655% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing); thymus: 63.4921% (minimum 65%, Missing); tongue: 47.6190% (minimum 70%, Missing)",-0.0150794,-0.22381,-0.25,0,80,unavailable,4,4.4,2.3,"tongue: 4.4 nTPM (protected, limit 2); retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155592,ZKSCAN2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 72.7273% (minimum 75%, Missing); bone marrow: 68.9655% (minimum 75%, Missing); cerebellum: 68.9655% (minimum 75%, Missing); cerebral cortex: 64.5161% (minimum 75%, Missing); heart muscle: 68.9655% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 67.7966% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); midbrain: 72.7273% (minimum 75%, Missing); parathyroid gland: 58.8235% (minimum 70%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); skeletal muscle: 56.3380% (minimum 75%, Missing); smooth muscle: 68.9655% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing); thymus: 63.4921% (minimum 65%, Missing); tongue: 47.6190% (minimum 70%, Missing)",-0.0150794,-0.22381,-0.25,0,80,unavailable,4,4.4,2.3,"tongue: 4.4 nTPM (protected, limit 3); retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155592,ZKSCAN2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 72.7273% (minimum 75%, Missing); bone marrow: 68.9655% (minimum 75%, Missing); cerebellum: 68.9655% (minimum 75%, Missing); cerebral cortex: 64.5161% (minimum 75%, Missing); heart muscle: 68.9655% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 67.7966% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); midbrain: 72.7273% (minimum 75%, Missing); parathyroid gland: 58.8235% (minimum 70%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); skeletal muscle: 56.3380% (minimum 75%, Missing); smooth muscle: 68.9655% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing); thymus: 63.4921% (minimum 65%, Missing); tongue: 47.6190% (minimum 70%, Missing)",-0.0150794,-0.22381,-0.25,0,80,unavailable,4,4.4,2.3,"tongue: 4.4 nTPM (protected, limit 3); retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155592,ZKSCAN2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 71.4286% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 72.7273% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 68.9655% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.9655% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.5161% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 68.9655% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.4286% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.7966% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.7273% (minimum 75%, Baseline (adaptation disabled)); liver: 71.4286% (minimum 75%, Baseline (adaptation disabled)); midbrain: 72.7273% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.8235% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.4286% (minimum 75%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 56.3380% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.9655% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.4286% (minimum 75%, Baseline (adaptation disabled)); thymus: 63.4921% (minimum 65%, Baseline (adaptation disabled)); tongue: 47.6190% (minimum 70%, Baseline (adaptation disabled))",-0.0150794,-0.22381,-0.25,0,80,unavailable,4,4.4,2.3,"tongue: 4.4 nTPM (protected, limit 3); retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155592,ZKSCAN2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.9888% (minimum 90%, Approved); adrenal gland: 62.1302% (minimum 99%, Missing); amygdala: 60.0000% (minimum 99%, Missing); basal ganglia: 59.6591% (minimum 99%, Missing); bone marrow: 64.4172% (minimum 98%, Approved); cerebellum: 75.5396% (minimum 99%, Missing); cerebral cortex: 64.0244% (minimum 99%, Missing); choroid plexus: 74.4681% (minimum 99%, Missing); colon: 58.6592% (minimum 97%, Missing); duodenum: 48.3871% (minimum 99%, Missing); esophagus: 52.2388% (minimum 97%, Missing); heart muscle: 64.0244% (minimum 99%, Missing); hippocampal formation: 58.9888% (minimum 99%, Missing); hypothalamus: 60.6936% (minimum 99%, Missing); kidney: 61.0465% (minimum 99%, Missing); liver: 58.3333% (minimum 99%, Missing); lung: 68.1818% (minimum 99%, Missing); lymph node: 55.8511% (minimum 95%, Approved); midbrain: 56.7568% (minimum 99%, Missing); pancreas: 58.0110% (minimum 99%, Missing); parathyroid gland: 69.0789% (minimum 97%, Missing); pituitary gland: 64.4172% (minimum 99%, Missing); rectum: 59.3220% (minimum 97%, Missing); retina: 63.6364% (minimum 99%, Missing); salivary gland: 55.2632% (minimum 97%, Missing); skeletal muscle: 55.8511% (minimum 99%, Missing); skin: 49.5283% (minimum 95%, Missing); small intestine: 57.0652% (minimum 99%, Missing); smooth muscle: 63.6364% (minimum 98%, Approved); spinal cord: 50.7246% (minimum 99%, Missing); spleen: 62.5000% (minimum 90%, Approved); stomach: 61.4035% (minimum 97%, Missing); thymus: 56.1497% (minimum 95%, Missing); thyroid gland: 56.1497% (minimum 95%, Missing); tongue: 57.0652% (minimum 97%, Missing); urinary bladder: 53.0303% (minimum 97%, Missing)",-0.454717,-0.447612,-0.506129,0,7,partial,11.2,9.6,10.7,"duodenum: 11.2 nTPM (vital, limit 1); skin: 10.7 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 2); urinary bladder: 9.3 nTPM (protected, limit 2); salivary gland: 8.5 nTPM (protected, limit 2); lymph node: 8.3 nTPM (protected, limit 4); skeletal muscle: 8.3 nTPM (vital, limit 1); thyroid gland: 8.2 nTPM (manageable, limit 5); thymus: 8.2 nTPM (manageable, limit 5); midbrain: 8 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 2); small intestine: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 2); hippocampal formation: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 2); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); adrenal gland: 6.4 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155621,C9orf85,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.9888% (minimum 60%, Approved); adrenal gland: 62.1302% (minimum 75%, Missing); amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 59.6591% (minimum 75%, Missing); bone marrow: 64.4172% (minimum 70%, Approved); cerebral cortex: 64.0244% (minimum 75%, Missing); choroid plexus: 74.4681% (minimum 75%, Missing); colon: 58.6592% (minimum 70%, Missing); duodenum: 48.3871% (minimum 75%, Missing); esophagus: 52.2388% (minimum 70%, Missing); heart muscle: 64.0244% (minimum 75%, Missing); hippocampal formation: 58.9888% (minimum 75%, Missing); hypothalamus: 60.6936% (minimum 75%, Missing); kidney: 61.0465% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lung: 68.1818% (minimum 75%, Missing); lymph node: 55.8511% (minimum 65%, Approved); midbrain: 56.7568% (minimum 75%, Missing); pancreas: 58.0110% (minimum 75%, Missing); parathyroid gland: 69.0789% (minimum 70%, Missing); pituitary gland: 64.4172% (minimum 75%, Missing); rectum: 59.3220% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); salivary gland: 55.2632% (minimum 70%, Missing); skeletal muscle: 55.8511% (minimum 75%, Missing); skin: 49.5283% (minimum 65%, Missing); small intestine: 57.0652% (minimum 75%, Missing); smooth muscle: 63.6364% (minimum 70%, Approved); spinal cord: 50.7246% (minimum 75%, Missing); stomach: 61.4035% (minimum 70%, Missing); thymus: 56.1497% (minimum 65%, Missing); thyroid gland: 56.1497% (minimum 65%, Missing); tongue: 57.0652% (minimum 70%, Missing); urinary bladder: 53.0303% (minimum 70%, Missing)",-0.154717,-0.177612,-0.266129,0,7,partial,11.2,9.6,10.7,"duodenum: 11.2 nTPM (vital, limit 1); skin: 10.7 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 2); urinary bladder: 9.3 nTPM (protected, limit 2); salivary gland: 8.5 nTPM (protected, limit 2); lymph node: 8.3 nTPM (protected, limit 4); skeletal muscle: 8.3 nTPM (vital, limit 1); thyroid gland: 8.2 nTPM (manageable, limit 5); thymus: 8.2 nTPM (manageable, limit 5); midbrain: 8 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 2); small intestine: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 2); hippocampal formation: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 2); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); adrenal gland: 6.4 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155621,C9orf85,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.9888% (minimum 60%, Approved); adrenal gland: 62.1302% (minimum 75%, Missing); amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 59.6591% (minimum 75%, Missing); bone marrow: 64.4172% (minimum 70%, Approved); cerebral cortex: 64.0244% (minimum 75%, Missing); choroid plexus: 74.4681% (minimum 75%, Missing); colon: 58.6592% (minimum 70%, Missing); duodenum: 48.3871% (minimum 75%, Missing); esophagus: 52.2388% (minimum 70%, Missing); heart muscle: 64.0244% (minimum 75%, Missing); hippocampal formation: 58.9888% (minimum 75%, Missing); hypothalamus: 60.6936% (minimum 75%, Missing); kidney: 61.0465% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lung: 68.1818% (minimum 75%, Missing); lymph node: 55.8511% (minimum 65%, Approved); midbrain: 56.7568% (minimum 75%, Missing); pancreas: 58.0110% (minimum 75%, Missing); parathyroid gland: 69.0789% (minimum 70%, Missing); pituitary gland: 64.4172% (minimum 75%, Missing); rectum: 59.3220% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); salivary gland: 55.2632% (minimum 70%, Missing); skeletal muscle: 55.8511% (minimum 75%, Missing); skin: 49.5283% (minimum 65%, Missing); small intestine: 57.0652% (minimum 75%, Missing); smooth muscle: 63.6364% (minimum 70%, Approved); spinal cord: 50.7246% (minimum 75%, Missing); stomach: 61.4035% (minimum 70%, Missing); thymus: 56.1497% (minimum 65%, Missing); thyroid gland: 56.1497% (minimum 65%, Missing); tongue: 57.0652% (minimum 70%, Missing); urinary bladder: 53.0303% (minimum 70%, Missing)",-0.154717,-0.177612,-0.266129,0,7,partial,11.2,9.6,10.7,"duodenum: 11.2 nTPM (vital, limit 1); skin: 10.7 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 3); urinary bladder: 9.3 nTPM (protected, limit 3); salivary gland: 8.5 nTPM (protected, limit 3); lymph node: 8.3 nTPM (protected, limit 4); skeletal muscle: 8.3 nTPM (vital, limit 1); thyroid gland: 8.2 nTPM (manageable, limit 5); thymus: 8.2 nTPM (manageable, limit 5); midbrain: 8 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 3); small intestine: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 3); hippocampal formation: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 3); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); adrenal gland: 6.4 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155621,C9orf85,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.9888% (minimum 60%, Approved); adrenal gland: 62.1302% (minimum 75%, Missing); amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 59.6591% (minimum 75%, Missing); bone marrow: 64.4172% (minimum 70%, Approved); cerebral cortex: 64.0244% (minimum 75%, Missing); choroid plexus: 74.4681% (minimum 75%, Missing); colon: 58.6592% (minimum 70%, Missing); duodenum: 48.3871% (minimum 75%, Missing); esophagus: 52.2388% (minimum 70%, Missing); heart muscle: 64.0244% (minimum 75%, Missing); hippocampal formation: 58.9888% (minimum 75%, Missing); hypothalamus: 60.6936% (minimum 75%, Missing); kidney: 61.0465% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lung: 68.1818% (minimum 75%, Missing); lymph node: 55.8511% (minimum 65%, Approved); midbrain: 56.7568% (minimum 75%, Missing); pancreas: 58.0110% (minimum 75%, Missing); parathyroid gland: 69.0789% (minimum 70%, Missing); pituitary gland: 64.4172% (minimum 75%, Missing); rectum: 59.3220% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); salivary gland: 55.2632% (minimum 70%, Missing); skeletal muscle: 55.8511% (minimum 75%, Missing); skin: 49.5283% (minimum 65%, Missing); small intestine: 57.0652% (minimum 75%, Missing); smooth muscle: 63.6364% (minimum 70%, Approved); spinal cord: 50.7246% (minimum 75%, Missing); stomach: 61.4035% (minimum 70%, Missing); thymus: 56.1497% (minimum 65%, Missing); thyroid gland: 56.1497% (minimum 65%, Missing); tongue: 57.0652% (minimum 70%, Missing); urinary bladder: 53.0303% (minimum 70%, Missing)",-0.154717,-0.177612,-0.266129,0,7,partial,11.2,9.6,10.7,"duodenum: 11.2 nTPM (vital, limit 1); skin: 10.7 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 3); urinary bladder: 9.3 nTPM (protected, limit 3); salivary gland: 8.5 nTPM (protected, limit 3); lymph node: 8.3 nTPM (protected, limit 4); skeletal muscle: 8.3 nTPM (vital, limit 1); thyroid gland: 8.2 nTPM (manageable, limit 5); thymus: 8.2 nTPM (manageable, limit 5); midbrain: 8 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 3); small intestine: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 3); hippocampal formation: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 3); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); adrenal gland: 6.4 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155621,C9orf85,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.9888% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.1302% (minimum 75%, Baseline (adaptation disabled)); amygdala: 60.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 59.6591% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 64.4172% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.0244% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.4681% (minimum 75%, Baseline (adaptation disabled)); colon: 58.6592% (minimum 70%, Baseline (adaptation disabled)); duodenum: 48.3871% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.2388% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.0244% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.9888% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.6936% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.0465% (minimum 75%, Baseline (adaptation disabled)); liver: 58.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 68.1818% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.8511% (minimum 70%, Baseline (adaptation disabled)); midbrain: 56.7568% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.0110% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.0789% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 64.4172% (minimum 75%, Baseline (adaptation disabled)); rectum: 59.3220% (minimum 70%, Baseline (adaptation disabled)); retina: 63.6364% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.2632% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.8511% (minimum 75%, Baseline (adaptation disabled)); skin: 49.5283% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.0652% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.6364% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.7246% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.4035% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.1497% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.1497% (minimum 65%, Baseline (adaptation disabled)); tongue: 57.0652% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 53.0303% (minimum 70%, Baseline (adaptation disabled))",-0.154717,-0.177612,-0.266129,0,7,partial,11.2,9.6,10.7,"duodenum: 11.2 nTPM (vital, limit 1); skin: 10.7 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 3); urinary bladder: 9.3 nTPM (protected, limit 3); salivary gland: 8.5 nTPM (protected, limit 3); skeletal muscle: 8.3 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 3); thyroid gland: 8.2 nTPM (manageable, limit 5); thymus: 8.2 nTPM (manageable, limit 5); midbrain: 8 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 3); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 3); adipose tissue: 7.3 nTPM (manageable, limit 5); hippocampal formation: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 3); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); adrenal gland: 6.4 nTPM (vital, limit 1); spleen: 6.3 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155621,C9orf85,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"lung: 97.2222% (minimum 99%, Missing)",0.0489621,0.0294808,-0.0177778,0,3,unreliable,5.5,0.1,0.2,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),50,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155622,XAGE2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.348962,0.299481,0.222222,0,3,unreliable,5.5,0.1,0.2,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),50,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155622,XAGE2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.348962,0.299481,0.222222,0,3,unreliable,5.5,0.1,0.2,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),50,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155622,XAGE2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.348962,0.299481,0.222222,0,3,unreliable,5.5,0.1,0.2,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),50,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155622,XAGE2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.348962,0.299481,0.222222,0,3,unreliable,5.5,0.1,0.2,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),50,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155622,XAGE2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.5752% (minimum 99%, Missing); basal ganglia: 91.5254% (minimum 99%, Missing); cerebellum: 84.3750% (minimum 99%, Missing); cerebral cortex: 92.3077% (minimum 99%, Missing); hippocampal formation: 94.7368% (minimum 99%, Missing); hypothalamus: 94.7368% (minimum 99%, Missing); midbrain: 96.4286% (minimum 99%, Missing); pituitary gland: 97.2973% (minimum 99%, Missing); small intestine: 98.1818% (minimum 99%, Missing); spinal cord: 98.1818% (minimum 99%, Missing)",0.0408257,0.0118182,-0.14625,0,80,unavailable,2,0.2,0.1,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155714,PDZD9,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340826,0.281818,0.09375,0,80,unavailable,2,0.2,0.1,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155714,PDZD9,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340826,0.281818,0.09375,0,80,unavailable,2,0.2,0.1,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155714,PDZD9,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340826,0.281818,0.09375,0,80,unavailable,2,0.2,0.1,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155714,PDZD9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340826,0.281818,0.09375,0,80,unavailable,2,0.2,0.1,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155714,PDZD9,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.5000% (minimum 99%, Missing); basal ganglia: 97.5000% (minimum 99%, Missing); bone marrow: 92.8571% (minimum 95%, Enhanced); cerebral cortex: 92.8571% (minimum 95%, Enhanced); hippocampal formation: 97.5000% (minimum 99%, Missing); liver: 92.8571% (minimum 95%, Enhanced); pituitary gland: 92.8571% (minimum 99%, Missing); spinal cord: 90.6977% (minimum 99%, Missing); spleen: 66.1017% (minimum 95%, Missing); thymus: 92.8571% (minimum 95%, Missing)",-0.288983,0.03,-0.0830233,0,1,partial,0.4,0.2,2,,spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155719,OTOA,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0110169,0.3,0.156977,0,1,partial,0.4,0.2,2,,spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155719,OTOA,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0110169,0.3,0.156977,0,1,partial,0.4,0.2,2,,spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155719,OTOA,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0110169,0.3,0.156977,0,1,partial,0.4,0.2,2,,spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155719,OTOA,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0110169,0.25122,0.156977,0,1,partial,0.4,0.2,2,,spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155719,OTOA,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.8571% (minimum 95%, Missing); adrenal gland: 94.3182% (minimum 99%, Missing); amygdala: 93.7853% (minimum 99%, Missing); basal ganglia: 89.2473% (minimum 99%, Missing); bone marrow: 76.8519% (minimum 99%, Missing); cerebellum: 96.5116% (minimum 99%, Missing); cerebral cortex: 94.3182% (minimum 99%, Missing); choroid plexus: 65.6126% (minimum 99%, Missing); colon: 95.4023% (minimum 97%, Missing); duodenum: 97.0760% (minimum 99%, Missing); esophagus: 93.7853% (minimum 97%, Missing); heart muscle: 80.1932% (minimum 99%, Missing); hippocampal formation: 90.7104% (minimum 99%, Missing); hypothalamus: 89.7297% (minimum 99%, Missing); kidney: 93.2584% (minimum 99%, Missing); liver: 95.9538% (minimum 99%, Missing); lung: 87.3684% (minimum 99%, Missing); lymph node: 92.2222% (minimum 97%, Missing); midbrain: 94.8571% (minimum 99%, Missing); pancreas: 94.8571% (minimum 99%, Missing); parathyroid gland: 95.9538% (minimum 97%, Missing); pituitary gland: 93.7853% (minimum 99%, Missing); rectum: 94.8571% (minimum 97%, Missing); retina: 83.8384% (minimum 99%, Missing); salivary gland: 93.7853% (minimum 97%, Missing); skeletal muscle: 90.7104% (minimum 99%, Missing); skin: 93.7853% (minimum 95%, Missing); small intestine: 94.3182% (minimum 99%, Missing); smooth muscle: 96.5116% (minimum 99%, Missing); spinal cord: 95.4023% (minimum 99%, Missing); thyroid gland: 91.2088% (minimum 95%, Missing); urinary bladder: 96.5116% (minimum 97%, Missing)",-0.0379121,-0.0477778,-0.333874,0,80,unavailable,8.7,1.4,1.6,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155749,FLACC1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.6126% (minimum 75%, Missing)",0.262088,0.222222,-0.0938735,0,80,unavailable,8.7,1.4,1.6,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155749,FLACC1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.6126% (minimum 75%, Missing)",0.262088,0.222222,-0.0938735,0,80,unavailable,8.7,1.4,1.6,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155749,FLACC1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.6126% (minimum 75%, Missing)",0.262088,0.222222,-0.0938735,0,80,unavailable,8.7,1.4,1.6,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155749,FLACC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.6126% (minimum 75%, Baseline (adaptation disabled))",0.262088,0.222222,-0.0938735,0,80,unavailable,8.7,1.4,1.6,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155749,FLACC1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2234% (minimum 99%, Missing); choroid plexus: 96.9925% (minimum 99%, Missing); heart muscle: 96.9925% (minimum 99%, Missing); midbrain: 98.9770% (minimum 99%, Missing); pituitary gland: 98.2234% (minimum 99%, Missing); retina: 97.7273% (minimum 99%, Missing); spinal cord: 97.2362% (minimum 99%, Missing)",0.0347328,0.0248586,-0.0200752,0,80,unavailable,1.2,0.2,0.6,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155754,C2CD6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334733,0.294859,0.219925,0,80,unavailable,1.2,0.2,0.6,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155754,C2CD6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334733,0.294859,0.219925,0,80,unavailable,1.2,0.2,0.6,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155754,C2CD6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334733,0.294859,0.219925,0,80,unavailable,1.2,0.2,0.6,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155754,C2CD6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334733,0.294859,0.219925,0,80,unavailable,1.2,0.2,0.6,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155754,C2CD6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155833,CYLC2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155833,CYLC2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155833,CYLC2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155833,CYLC2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155833,CYLC2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0473333,0.03,0.00468085,0,2,partial,0.2,0.1,0.2,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155875,SAXO1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.347333,0.3,0.244681,0,2,partial,0.2,0.1,0.2,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155875,SAXO1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.347333,0.3,0.244681,0,2,partial,0.2,0.1,0.2,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155875,SAXO1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.347333,0.3,0.244681,0,2,partial,0.2,0.1,0.2,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155875,SAXO1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.344681,0.297333,0.244681,0,2,partial,0.2,0.1,0.2,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155875,SAXO1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155890,TRIM42,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155890,TRIM42,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155890,TRIM42,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155890,TRIM42,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000155890,TRIM42,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00224806,0,3,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156009,MAGEA8,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,"Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.242248,0,3,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156009,MAGEA8,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,"Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.242248,0,3,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156009,MAGEA8,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,"Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.242248,0,3,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156009,MAGEA8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,"Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.342248,0.3,0.234615,0,3,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156009,MAGEA8,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,"Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 81.8565% (minimum 99%, Missing); amygdala: 86.2222% (minimum 99%, Missing); basal ganglia: 81.8565% (minimum 99%, Missing); cerebellum: 94.1748% (minimum 95%, Enhanced); cerebral cortex: 91.9431% (minimum 95%, Enhanced); choroid plexus: 24.8718% (minimum 99%, Missing); heart muscle: 94.1748% (minimum 95%, Enhanced); hippocampal formation: 83.2618% (minimum 99%, Missing); hypothalamus: 80.1653% (minimum 99%, Missing); kidney: 71.8519% (minimum 95%, Enhanced); liver: 89.8148% (minimum 95%, Enhanced); lung: 86.9955% (minimum 99%, Missing); midbrain: 91.5094% (minimum 99%, Missing); pancreas: 87.3874% (minimum 95%, Enhanced); pituitary gland: 59.6923% (minimum 99%, Missing); retina: 65.9864% (minimum 99%, Missing); spinal cord: 91.5094% (minimum 99%, Missing)",0.02,0,-0.741282,0,6,partial,58.6,4.1,6.1,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156042,CFAP70,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 24.8718% (minimum 75%, Missing); pituitary gland: 59.6923% (minimum 75%, Missing); retina: 65.9864% (minimum 75%, Missing)",0.260784,0.27,-0.501282,0,6,partial,58.6,4.1,6.1,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156042,CFAP70,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 24.8718% (minimum 75%, Missing); pituitary gland: 59.6923% (minimum 75%, Missing); retina: 65.9864% (minimum 75%, Missing)",0.260784,0.27,-0.501282,0,6,partial,58.6,4.1,6.1,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156042,CFAP70,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 24.8718% (minimum 75%, Missing); pituitary gland: 59.6923% (minimum 75%, Missing); retina: 65.9864% (minimum 75%, Missing)",0.260784,0.27,-0.501282,0,6,partial,58.6,4.1,6.1,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156042,CFAP70,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 24.8718% (minimum 75%, Baseline (adaptation disabled)); kidney: 71.8519% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 59.6923% (minimum 75%, Baseline (adaptation disabled)); retina: 65.9864% (minimum 75%, Baseline (adaptation disabled))",0.110784,0.125532,-0.501282,0,6,partial,58.6,4.1,6.1,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 3); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156042,CFAP70,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.0909% (minimum 95%, Missing); adrenal gland: 69.0909% (minimum 99%, Missing); amygdala: 63.3333% (minimum 99%, Missing); basal ganglia: 58.4615% (minimum 99%, Missing); bone marrow: 82.6087% (minimum 99%, Missing); cerebellum: 67.8571% (minimum 98%, Approved); cerebral cortex: 61.2903% (minimum 99%, Missing); choroid plexus: 59.3750% (minimum 99%, Missing); colon: 79.1667% (minimum 97%, Missing); duodenum: 80.8511% (minimum 99%, Missing); esophagus: 79.1667% (minimum 97%, Missing); heart muscle: 59.3750% (minimum 99%, Missing); hippocampal formation: 64.4068% (minimum 99%, Missing); hypothalamus: 63.3333% (minimum 99%, Missing); kidney: 62.2951% (minimum 99%, Missing); liver: 69.0909% (minimum 99%, Missing); lung: 71.6981% (minimum 99%, Missing); lymph node: 64.4068% (minimum 97%, Missing); midbrain: 64.4068% (minimum 99%, Missing); pancreas: 76.0000% (minimum 99%, Missing); parathyroid gland: 53.5211% (minimum 97%, Missing); pituitary gland: 63.3333% (minimum 99%, Missing); rectum: 80.8511% (minimum 97%, Missing); retina: 43.6782% (minimum 99%, Missing); salivary gland: 71.6981% (minimum 95%, Approved); skeletal muscle: 79.1667% (minimum 99%, Missing); skin: 71.6981% (minimum 90%, Approved); small intestine: 79.1667% (minimum 99%, Missing); smooth muscle: 63.3333% (minimum 98%, Approved); spinal cord: 67.8571% (minimum 99%, Missing); spleen: 70.3704% (minimum 95%, Missing); stomach: 77.5510% (minimum 97%, Missing); thymus: 62.2951% (minimum 95%, Missing); thyroid gland: 61.2903% (minimum 95%, Missing); tongue: 67.8571% (minimum 97%, Missing); urinary bladder: 77.5510% (minimum 97%, Missing)",-0.337097,-0.434789,-0.553218,0,0,routine_complete,4.9,3.3,2.4,"retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156172,CFAP418,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0909% (minimum 75%, Missing); amygdala: 63.3333% (minimum 75%, Missing); basal ganglia: 58.4615% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 70%, Approved); cerebral cortex: 61.2903% (minimum 75%, Missing); choroid plexus: 59.3750% (minimum 75%, Missing); heart muscle: 59.3750% (minimum 75%, Missing); hippocampal formation: 64.4068% (minimum 75%, Missing); hypothalamus: 63.3333% (minimum 75%, Missing); kidney: 62.2951% (minimum 75%, Missing); liver: 69.0909% (minimum 75%, Missing); lung: 71.6981% (minimum 75%, Missing); lymph node: 64.4068% (minimum 70%, Missing); midbrain: 64.4068% (minimum 75%, Missing); parathyroid gland: 53.5211% (minimum 70%, Missing); pituitary gland: 63.3333% (minimum 75%, Missing); retina: 43.6782% (minimum 75%, Missing); smooth muscle: 63.3333% (minimum 70%, Approved); spinal cord: 67.8571% (minimum 75%, Missing); thymus: 62.2951% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 67.8571% (minimum 70%, Missing)",-0.0370968,-0.164789,-0.313218,0,0,routine_complete,4.9,3.3,2.4,"retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156172,CFAP418,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0909% (minimum 75%, Missing); amygdala: 63.3333% (minimum 75%, Missing); basal ganglia: 58.4615% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 70%, Approved); cerebral cortex: 61.2903% (minimum 75%, Missing); choroid plexus: 59.3750% (minimum 75%, Missing); heart muscle: 59.3750% (minimum 75%, Missing); hippocampal formation: 64.4068% (minimum 75%, Missing); hypothalamus: 63.3333% (minimum 75%, Missing); kidney: 62.2951% (minimum 75%, Missing); liver: 69.0909% (minimum 75%, Missing); lung: 71.6981% (minimum 75%, Missing); lymph node: 64.4068% (minimum 70%, Missing); midbrain: 64.4068% (minimum 75%, Missing); parathyroid gland: 53.5211% (minimum 70%, Missing); pituitary gland: 63.3333% (minimum 75%, Missing); retina: 43.6782% (minimum 75%, Missing); smooth muscle: 63.3333% (minimum 70%, Approved); spinal cord: 67.8571% (minimum 75%, Missing); thymus: 62.2951% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 67.8571% (minimum 70%, Missing)",-0.0370968,-0.164789,-0.313218,0,0,routine_complete,4.9,3.3,2.4,"retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156172,CFAP418,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0909% (minimum 75%, Missing); amygdala: 63.3333% (minimum 75%, Missing); basal ganglia: 58.4615% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 70%, Approved); cerebral cortex: 61.2903% (minimum 75%, Missing); choroid plexus: 59.3750% (minimum 75%, Missing); heart muscle: 59.3750% (minimum 75%, Missing); hippocampal formation: 64.4068% (minimum 75%, Missing); hypothalamus: 63.3333% (minimum 75%, Missing); kidney: 62.2951% (minimum 75%, Missing); liver: 69.0909% (minimum 75%, Missing); lung: 71.6981% (minimum 75%, Missing); lymph node: 64.4068% (minimum 70%, Missing); midbrain: 64.4068% (minimum 75%, Missing); parathyroid gland: 53.5211% (minimum 70%, Missing); pituitary gland: 63.3333% (minimum 75%, Missing); retina: 43.6782% (minimum 75%, Missing); smooth muscle: 63.3333% (minimum 70%, Approved); spinal cord: 67.8571% (minimum 75%, Missing); thymus: 62.2951% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 67.8571% (minimum 70%, Missing)",-0.0370968,-0.164789,-0.313218,0,0,routine_complete,4.9,3.3,2.4,"retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156172,CFAP418,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0909% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.4615% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.8571% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.2903% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 59.3750% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 59.3750% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.4068% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.3333% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.2951% (minimum 75%, Baseline (adaptation disabled)); liver: 69.0909% (minimum 75%, Baseline (adaptation disabled)); lung: 71.6981% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.4068% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.4068% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 53.5211% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.3333% (minimum 75%, Baseline (adaptation disabled)); retina: 43.6782% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.8571% (minimum 75%, Baseline (adaptation disabled)); thymus: 62.2951% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 61.2903% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.8571% (minimum 70%, Baseline (adaptation disabled))",-0.0370968,-0.164789,-0.313218,0,0,routine_complete,4.9,3.3,2.4,"retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156172,CFAP418,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 83.3333% (minimum 99%, Missing); cerebellum: 45.4545% (minimum 99%, Missing); choroid plexus: 38.4615% (minimum 99%, Missing); retina: 0.2156% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing)",-0.116667,0.03,-0.987844,0,80,unavailable,231.4,0,0.1,"retina: 231.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156194,PPEF2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 45.4545% (minimum 75%, Missing); choroid plexus: 38.4615% (minimum 75%, Missing); retina: 0.2156% (minimum 75%, Missing)",0.183333,0.3,-0.747844,0,80,unavailable,231.4,0,0.1,"retina: 231.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156194,PPEF2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 45.4545% (minimum 75%, Missing); choroid plexus: 38.4615% (minimum 75%, Missing); retina: 0.2156% (minimum 75%, Missing)",0.183333,0.3,-0.747844,0,80,unavailable,231.4,0,0.1,"retina: 231.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156194,PPEF2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 45.4545% (minimum 75%, Missing); choroid plexus: 38.4615% (minimum 75%, Missing); retina: 0.2156% (minimum 75%, Missing)",0.183333,0.3,-0.747844,0,80,unavailable,231.4,0,0.1,"retina: 231.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156194,PPEF2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 45.4545% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 38.4615% (minimum 75%, Baseline (adaptation disabled)); retina: 0.2156% (minimum 75%, Baseline (adaptation disabled))",0.183333,0.3,-0.747844,0,80,unavailable,231.4,0,0.1,"retina: 231.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156194,PPEF2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.3607% (minimum 99%, Missing); retina: 93.7500% (minimum 99%, Missing)",0.05,0.03,-0.0525,0,2,partial,0.4,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156269,NAA11,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,2,partial,0.4,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156269,NAA11,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,2,partial,0.4,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156269,NAA11,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,2,partial,0.4,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156269,NAA11,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.333607,0.3,0.1875,0,2,partial,0.4,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156269,NAA11,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.1682% (minimum 90%, Approved); adrenal gland: 80.6931% (minimum 98%, Approved); amygdala: 92.0904% (minimum 99%, Missing); basal ganglia: 93.1429% (minimum 99%, Missing); bone marrow: 35.6674% (minimum 99%, Missing); cerebellum: 95.5078% (minimum 98%, Approved); cerebral cortex: 84.4560% (minimum 98%, Approved); choroid plexus: 91.5730% (minimum 99%, Missing); colon: 79.1262% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 68.7764% (minimum 97%, Missing); heart muscle: 79.3831% (minimum 99%, Missing); hippocampal formation: 92.2642% (minimum 99%, Missing); hypothalamus: 92.6136% (minimum 99%, Missing); kidney: 76.1682% (minimum 98%, Approved); liver: 62.2930% (minimum 98%, Approved); lung: 70.2586% (minimum 98%, Approved); lymph node: 74.8851% (minimum 95%, Approved); midbrain: 90.7236% (minimum 99%, Missing); pancreas: 74.5427% (minimum 98%, Approved); parathyroid gland: 85.7895% (minimum 95%, Approved); pituitary gland: 93.6782% (minimum 99%, Missing); rectum: 79.3831% (minimum 95%, Approved); retina: 80.9603% (minimum 99%, Missing); salivary gland: 74.3161% (minimum 95%, Approved); skeletal muscle: 65.8143% (minimum 98%, Approved); skin: 68.3916% (minimum 95%, Missing); small intestine: 74.3161% (minimum 99%, Missing); smooth muscle: 76.0498% (minimum 99%, Missing); spinal cord: 89.7248% (minimum 99%, Missing); spleen: 70.8696% (minimum 90%, Approved); stomach: 78.8710% (minimum 97%, Missing); thymus: 77.9904% (minimum 95%, Missing); thyroid gland: 80.0327% (minimum 90%, Approved); tongue: 79.9020% (minimum 97%, Missing); urinary bladder: 63.0968% (minimum 97%, Missing)",-0.266084,-0.339032,-0.633326,0,8,partial,88.2,28.6,22.6,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 2); urinary bladder: 28.6 nTPM (protected, limit 2); skeletal muscle: 25.4 nTPM (vital, limit 2); skin: 22.6 nTPM (manageable, limit 5); esophagus: 22.2 nTPM (protected, limit 2); lung: 20.7 nTPM (vital, limit 2); spleen: 20.1 nTPM (manageable, limit 10); small intestine: 16.9 nTPM (vital, limit 1); salivary gland: 16.9 nTPM (protected, limit 4); pancreas: 16.7 nTPM (vital, limit 2); lymph node: 16.4 nTPM (protected, limit 4); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); adipose tissue: 15.3 nTPM (manageable, limit 10); kidney: 15.3 nTPM (vital, limit 2); thymus: 13.8 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 2); colon: 12.9 nTPM (protected, limit 2); heart muscle: 12.7 nTPM (vital, limit 1); rectum: 12.7 nTPM (protected, limit 4); tongue: 12.3 nTPM (protected, limit 2); thyroid gland: 12.2 nTPM (manageable, limit 10); adrenal gland: 11.7 nTPM (vital, limit 2); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 2); parathyroid gland: 8.1 nTPM (protected, limit 4); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156273,BACH1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.6674% (minimum 75%, Missing); esophagus: 68.7764% (minimum 70%, Missing); liver: 62.2930% (minimum 70%, Approved); skeletal muscle: 65.8143% (minimum 70%, Approved); small intestine: 74.3161% (minimum 75%, Missing); urinary bladder: 63.0968% (minimum 70%, Missing)",0.0339161,-0.0690323,-0.393326,0,8,partial,88.2,28.6,22.6,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 2); urinary bladder: 28.6 nTPM (protected, limit 2); skeletal muscle: 25.4 nTPM (vital, limit 2); skin: 22.6 nTPM (manageable, limit 5); esophagus: 22.2 nTPM (protected, limit 2); lung: 20.7 nTPM (vital, limit 2); spleen: 20.1 nTPM (manageable, limit 10); small intestine: 16.9 nTPM (vital, limit 1); salivary gland: 16.9 nTPM (protected, limit 4); pancreas: 16.7 nTPM (vital, limit 2); lymph node: 16.4 nTPM (protected, limit 4); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); adipose tissue: 15.3 nTPM (manageable, limit 10); kidney: 15.3 nTPM (vital, limit 2); thymus: 13.8 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 2); colon: 12.9 nTPM (protected, limit 2); heart muscle: 12.7 nTPM (vital, limit 1); rectum: 12.7 nTPM (protected, limit 4); tongue: 12.3 nTPM (protected, limit 2); thyroid gland: 12.2 nTPM (manageable, limit 10); adrenal gland: 11.7 nTPM (vital, limit 2); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 2); parathyroid gland: 8.1 nTPM (protected, limit 4); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156273,BACH1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.6674% (minimum 75%, Missing); esophagus: 68.7764% (minimum 70%, Missing); liver: 62.2930% (minimum 70%, Approved); skeletal muscle: 65.8143% (minimum 70%, Approved); small intestine: 74.3161% (minimum 75%, Missing); urinary bladder: 63.0968% (minimum 70%, Missing)",0.0339161,-0.0690323,-0.393326,0,8,partial,88.2,28.6,22.6,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 2); urinary bladder: 28.6 nTPM (protected, limit 3); skeletal muscle: 25.4 nTPM (vital, limit 2); skin: 22.6 nTPM (manageable, limit 5); esophagus: 22.2 nTPM (protected, limit 3); lung: 20.7 nTPM (vital, limit 2); spleen: 20.1 nTPM (manageable, limit 10); small intestine: 16.9 nTPM (vital, limit 1); salivary gland: 16.9 nTPM (protected, limit 4); pancreas: 16.7 nTPM (vital, limit 2); lymph node: 16.4 nTPM (protected, limit 4); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); adipose tissue: 15.3 nTPM (manageable, limit 10); kidney: 15.3 nTPM (vital, limit 2); thymus: 13.8 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 3); colon: 12.9 nTPM (protected, limit 3); heart muscle: 12.7 nTPM (vital, limit 1); rectum: 12.7 nTPM (protected, limit 4); tongue: 12.3 nTPM (protected, limit 3); thyroid gland: 12.2 nTPM (manageable, limit 10); adrenal gland: 11.7 nTPM (vital, limit 2); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 2); parathyroid gland: 8.1 nTPM (protected, limit 4); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156273,BACH1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.6674% (minimum 75%, Missing); esophagus: 68.7764% (minimum 70%, Missing); liver: 62.2930% (minimum 70%, Approved); skeletal muscle: 65.8143% (minimum 70%, Approved); small intestine: 74.3161% (minimum 75%, Missing); urinary bladder: 63.0968% (minimum 70%, Missing)",0.0339161,-0.0690323,-0.393326,0,8,partial,88.2,28.6,22.6,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 2); urinary bladder: 28.6 nTPM (protected, limit 3); skeletal muscle: 25.4 nTPM (vital, limit 2); skin: 22.6 nTPM (manageable, limit 5); esophagus: 22.2 nTPM (protected, limit 3); lung: 20.7 nTPM (vital, limit 2); spleen: 20.1 nTPM (manageable, limit 10); small intestine: 16.9 nTPM (vital, limit 1); salivary gland: 16.9 nTPM (protected, limit 4); pancreas: 16.7 nTPM (vital, limit 2); lymph node: 16.4 nTPM (protected, limit 4); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); adipose tissue: 15.3 nTPM (manageable, limit 10); kidney: 15.3 nTPM (vital, limit 2); thymus: 13.8 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 3); colon: 12.9 nTPM (protected, limit 3); heart muscle: 12.7 nTPM (vital, limit 1); rectum: 12.7 nTPM (protected, limit 4); tongue: 12.3 nTPM (protected, limit 3); thyroid gland: 12.2 nTPM (manageable, limit 10); adrenal gland: 11.7 nTPM (vital, limit 2); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 2); parathyroid gland: 8.1 nTPM (protected, limit 4); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156273,BACH1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.6674% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.7764% (minimum 70%, Baseline (adaptation disabled)); liver: 62.2930% (minimum 75%, Baseline (adaptation disabled)); lung: 70.2586% (minimum 75%, Baseline (adaptation disabled)); pancreas: 74.5427% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 65.8143% (minimum 75%, Baseline (adaptation disabled)); small intestine: 74.3161% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 63.0968% (minimum 70%, Baseline (adaptation disabled))",0.0339161,-0.0690323,-0.393326,0,8,partial,88.2,28.6,22.6,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 1); urinary bladder: 28.6 nTPM (protected, limit 3); skeletal muscle: 25.4 nTPM (vital, limit 1); skin: 22.6 nTPM (manageable, limit 5); esophagus: 22.2 nTPM (protected, limit 3); lung: 20.7 nTPM (vital, limit 1); spleen: 20.1 nTPM (manageable, limit 5); small intestine: 16.9 nTPM (vital, limit 1); salivary gland: 16.9 nTPM (protected, limit 3); pancreas: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 3); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); adipose tissue: 15.3 nTPM (manageable, limit 5); kidney: 15.3 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 3); colon: 12.9 nTPM (protected, limit 3); heart muscle: 12.7 nTPM (vital, limit 1); rectum: 12.7 nTPM (protected, limit 3); tongue: 12.3 nTPM (protected, limit 3); thyroid gland: 12.2 nTPM (manageable, limit 5); adrenal gland: 11.7 nTPM (vital, limit 1); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 3); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156273,BACH1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.5517% (minimum 90%, Approved); adrenal gland: 74.3119% (minimum 99%, Missing); amygdala: 68.9362% (minimum 99%, Missing); basal ganglia: 61.5970% (minimum 99%, Missing); bone marrow: 57.2438% (minimum 98%, Approved); cerebellum: 65.3226% (minimum 99%, Missing); cerebral cortex: 68.6441% (minimum 99%, Missing); choroid plexus: 51.2658% (minimum 99%, Missing); colon: 64.8000% (minimum 97%, Missing); duodenum: 84.8168% (minimum 99%, Missing); esophagus: 75.3488% (minimum 97%, Missing); heart muscle: 63.0350% (minimum 99%, Missing); hippocampal formation: 64.0316% (minimum 99%, Missing); hypothalamus: 58.0645% (minimum 99%, Missing); kidney: 72.9730% (minimum 99%, Missing); liver: 81.8182% (minimum 99%, Missing); lung: 52.9412% (minimum 99%, Missing); lymph node: 81.8182% (minimum 97%, Missing); midbrain: 62.5483% (minimum 99%, Missing); pancreas: 69.2308% (minimum 99%, Missing); parathyroid gland: 86.6310% (minimum 97%, Missing); pituitary gland: 33.6100% (minimum 99%, Missing); rectum: 82.2335% (minimum 97%, Missing); retina: 57.8571% (minimum 99%, Missing); salivary gland: 76.0563% (minimum 97%, Missing); skeletal muscle: 58.2734% (minimum 99%, Missing); skin: 73.6364% (minimum 95%, Missing); small intestine: 64.0316% (minimum 99%, Missing); smooth muscle: 79.0244% (minimum 99%, Missing); spinal cord: 59.7786% (minimum 99%, Missing); spleen: 76.4151% (minimum 90%, Approved); stomach: 71.0526% (minimum 97%, Missing); thymus: 77.8846% (minimum 95%, Missing); thyroid gland: 63.2812% (minimum 95%, Missing); tongue: 81.8182% (minimum 97%, Missing); urinary bladder: 65.8537% (minimum 97%, Missing)",-0.434483,-0.322,-0.6539,0,4,partial,32,8.8,18.6,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (manageable, limit 10); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 2); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 2); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 2); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); kidney: 6 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); salivary gland: 5.1 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); lymph node: 3.6 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156313,RPGR,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.5517% (minimum 60%, Approved); adrenal gland: 74.3119% (minimum 75%, Missing); amygdala: 68.9362% (minimum 75%, Missing); basal ganglia: 61.5970% (minimum 75%, Missing); bone marrow: 57.2438% (minimum 70%, Approved); cerebellum: 65.3226% (minimum 75%, Missing); cerebral cortex: 68.6441% (minimum 75%, Missing); choroid plexus: 51.2658% (minimum 75%, Missing); colon: 64.8000% (minimum 70%, Missing); heart muscle: 63.0350% (minimum 75%, Missing); hippocampal formation: 64.0316% (minimum 75%, Missing); hypothalamus: 58.0645% (minimum 75%, Missing); kidney: 72.9730% (minimum 75%, Missing); lung: 52.9412% (minimum 75%, Missing); midbrain: 62.5483% (minimum 75%, Missing); pancreas: 69.2308% (minimum 75%, Missing); pituitary gland: 33.6100% (minimum 75%, Missing); retina: 57.8571% (minimum 75%, Missing); skeletal muscle: 58.2734% (minimum 75%, Missing); small intestine: 64.0316% (minimum 75%, Missing); spinal cord: 59.7786% (minimum 75%, Missing); thyroid gland: 63.2812% (minimum 65%, Missing); urinary bladder: 65.8537% (minimum 70%, Missing)",-0.134483,-0.052,-0.4139,0,4,partial,32,8.8,18.6,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (manageable, limit 10); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 2); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 2); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 2); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); kidney: 6 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); salivary gland: 5.1 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); lymph node: 3.6 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156313,RPGR,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.5517% (minimum 60%, Approved); adrenal gland: 74.3119% (minimum 75%, Missing); amygdala: 68.9362% (minimum 75%, Missing); basal ganglia: 61.5970% (minimum 75%, Missing); bone marrow: 57.2438% (minimum 70%, Approved); cerebellum: 65.3226% (minimum 75%, Missing); cerebral cortex: 68.6441% (minimum 75%, Missing); choroid plexus: 51.2658% (minimum 75%, Missing); colon: 64.8000% (minimum 70%, Missing); heart muscle: 63.0350% (minimum 75%, Missing); hippocampal formation: 64.0316% (minimum 75%, Missing); hypothalamus: 58.0645% (minimum 75%, Missing); kidney: 72.9730% (minimum 75%, Missing); lung: 52.9412% (minimum 75%, Missing); midbrain: 62.5483% (minimum 75%, Missing); pancreas: 69.2308% (minimum 75%, Missing); pituitary gland: 33.6100% (minimum 75%, Missing); retina: 57.8571% (minimum 75%, Missing); skeletal muscle: 58.2734% (minimum 75%, Missing); small intestine: 64.0316% (minimum 75%, Missing); spinal cord: 59.7786% (minimum 75%, Missing); thyroid gland: 63.2812% (minimum 65%, Missing); urinary bladder: 65.8537% (minimum 70%, Missing)",-0.134483,-0.052,-0.4139,0,4,partial,32,8.8,18.6,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (manageable, limit 10); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 2); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 3); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 3); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); kidney: 6 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); salivary gland: 5.1 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); liver: 3.6 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156313,RPGR,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.5517% (minimum 60%, Approved); adrenal gland: 74.3119% (minimum 75%, Missing); amygdala: 68.9362% (minimum 75%, Missing); basal ganglia: 61.5970% (minimum 75%, Missing); bone marrow: 57.2438% (minimum 70%, Approved); cerebellum: 65.3226% (minimum 75%, Missing); cerebral cortex: 68.6441% (minimum 75%, Missing); choroid plexus: 51.2658% (minimum 75%, Missing); colon: 64.8000% (minimum 70%, Missing); heart muscle: 63.0350% (minimum 75%, Missing); hippocampal formation: 64.0316% (minimum 75%, Missing); hypothalamus: 58.0645% (minimum 75%, Missing); kidney: 72.9730% (minimum 75%, Missing); lung: 52.9412% (minimum 75%, Missing); midbrain: 62.5483% (minimum 75%, Missing); pancreas: 69.2308% (minimum 75%, Missing); pituitary gland: 33.6100% (minimum 75%, Missing); retina: 57.8571% (minimum 75%, Missing); skeletal muscle: 58.2734% (minimum 75%, Missing); small intestine: 64.0316% (minimum 75%, Missing); spinal cord: 59.7786% (minimum 75%, Missing); thyroid gland: 63.2812% (minimum 65%, Missing); urinary bladder: 65.8537% (minimum 70%, Missing)",-0.134483,-0.052,-0.4139,0,4,partial,32,8.8,18.6,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (manageable, limit 10); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 2); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 3); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 3); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); kidney: 6 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); salivary gland: 5.1 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); liver: 3.6 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156313,RPGR,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.5517% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 74.3119% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.9362% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.5970% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 57.2438% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.3226% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.6441% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 51.2658% (minimum 75%, Baseline (adaptation disabled)); colon: 64.8000% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.0350% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.0316% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.0645% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.9730% (minimum 75%, Baseline (adaptation disabled)); lung: 52.9412% (minimum 75%, Baseline (adaptation disabled)); midbrain: 62.5483% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.2308% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 33.6100% (minimum 75%, Baseline (adaptation disabled)); retina: 57.8571% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 58.2734% (minimum 75%, Baseline (adaptation disabled)); small intestine: 64.0316% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.7786% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 63.2812% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 65.8537% (minimum 70%, Baseline (adaptation disabled))",-0.184483,-0.052,-0.4139,0,4,partial,32,8.8,18.6,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (manageable, limit 5); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 1); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 3); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 3); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); kidney: 6 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); salivary gland: 5.1 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); liver: 3.6 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156313,RPGR,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.4643% (minimum 95%, Missing); adrenal gland: 80.5430% (minimum 99%, Missing); amygdala: 78.0702% (minimum 99%, Missing); basal ganglia: 77.3913% (minimum 99%, Missing); bone marrow: 64.4928% (minimum 99%, Missing); cerebellum: 83.9623% (minimum 99%, Missing); cerebral cortex: 72.9508% (minimum 99%, Missing); choroid plexus: 69.5312% (minimum 99%, Missing); colon: 77.7293% (minimum 97%, Missing); duodenum: 79.8206% (minimum 99%, Missing); esophagus: 79.1111% (minimum 97%, Missing); heart muscle: 70.9163% (minimum 99%, Missing); hippocampal formation: 75.7447% (minimum 99%, Missing); hypothalamus: 79.8206% (minimum 99%, Missing); kidney: 79.1111% (minimum 99%, Missing); liver: 85.5769% (minimum 99%, Missing); lung: 74.4770% (minimum 99%, Missing); lymph node: 66.9173% (minimum 97%, Missing); midbrain: 72.6531% (minimum 99%, Missing); pancreas: 75.7447% (minimum 99%, Missing); parathyroid gland: 83.9623% (minimum 97%, Missing); pituitary gland: 86.4078% (minimum 99%, Missing); rectum: 74.1667% (minimum 97%, Missing); retina: 80.9091% (minimum 99%, Missing); salivary gland: 82.0276% (minimum 97%, Missing); skeletal muscle: 81.6514% (minimum 99%, Missing); skin: 80.5430% (minimum 95%, Missing); small intestine: 75.1055% (minimum 99%, Missing); smooth muscle: 76.7241% (minimum 99%, Missing); spinal cord: 63.5714% (minimum 99%, Missing); spleen: 74.4770% (minimum 95%, Missing); stomach: 77.0563% (minimum 97%, Missing); thymus: 61.1684% (minimum 95%, Missing); thyroid gland: 71.4859% (minimum 95%, Missing); tongue: 78.0702% (minimum 97%, Missing); urinary bladder: 77.3913% (minimum 97%, Missing)",-0.338316,-0.300827,-0.354286,0,80,unavailable,10.2,8.8,11.3,"thymus: 11.3 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); small intestine: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); urinary bladder: 5.2 nTPM (protected, limit 2); basal ganglia: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); parathyroid gland: 3.4 nTPM (protected, limit 2); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156384,SFR1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 64.4928% (minimum 75%, Missing); cerebral cortex: 72.9508% (minimum 75%, Missing); choroid plexus: 69.5312% (minimum 75%, Missing); heart muscle: 70.9163% (minimum 75%, Missing); lung: 74.4770% (minimum 75%, Missing); lymph node: 66.9173% (minimum 70%, Missing); midbrain: 72.6531% (minimum 75%, Missing); spinal cord: 63.5714% (minimum 75%, Missing); thymus: 61.1684% (minimum 65%, Missing)",-0.0383162,-0.0308271,-0.114286,0,80,unavailable,10.2,8.8,11.3,"thymus: 11.3 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); small intestine: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); urinary bladder: 5.2 nTPM (protected, limit 2); basal ganglia: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); parathyroid gland: 3.4 nTPM (protected, limit 2); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156384,SFR1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 64.4928% (minimum 75%, Missing); cerebral cortex: 72.9508% (minimum 75%, Missing); choroid plexus: 69.5312% (minimum 75%, Missing); heart muscle: 70.9163% (minimum 75%, Missing); lung: 74.4770% (minimum 75%, Missing); lymph node: 66.9173% (minimum 70%, Missing); midbrain: 72.6531% (minimum 75%, Missing); spinal cord: 63.5714% (minimum 75%, Missing); thymus: 61.1684% (minimum 65%, Missing)",-0.0383162,-0.0308271,-0.114286,0,80,unavailable,10.2,8.8,11.3,"thymus: 11.3 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); small intestine: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); urinary bladder: 5.2 nTPM (protected, limit 3); basal ganglia: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); parathyroid gland: 3.4 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156384,SFR1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 64.4928% (minimum 75%, Missing); cerebral cortex: 72.9508% (minimum 75%, Missing); choroid plexus: 69.5312% (minimum 75%, Missing); heart muscle: 70.9163% (minimum 75%, Missing); lung: 74.4770% (minimum 75%, Missing); lymph node: 66.9173% (minimum 70%, Missing); midbrain: 72.6531% (minimum 75%, Missing); spinal cord: 63.5714% (minimum 75%, Missing); thymus: 61.1684% (minimum 65%, Missing)",-0.0383162,-0.0308271,-0.114286,0,80,unavailable,10.2,8.8,11.3,"thymus: 11.3 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); small intestine: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); urinary bladder: 5.2 nTPM (protected, limit 3); basal ganglia: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); parathyroid gland: 3.4 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156384,SFR1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 64.4928% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.9508% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.5312% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.9163% (minimum 75%, Baseline (adaptation disabled)); lung: 74.4770% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.9173% (minimum 70%, Baseline (adaptation disabled)); midbrain: 72.6531% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.5714% (minimum 75%, Baseline (adaptation disabled)); thymus: 61.1684% (minimum 65%, Baseline (adaptation disabled))",-0.0383162,-0.0308271,-0.114286,0,80,unavailable,10.2,8.8,11.3,"thymus: 11.3 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); small intestine: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); urinary bladder: 5.2 nTPM (protected, limit 3); basal ganglia: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); parathyroid gland: 3.4 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156384,SFR1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.9831% (minimum 95%, Missing); amygdala: 93.7500% (minimum 99%, Missing); basal ganglia: 98.1308% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); colon: 93.7500% (minimum 97%, Missing); duodenum: 97.2222% (minimum 99%, Missing); esophagus: 96.3303% (minimum 97%, Missing); heart muscle: 79.5455% (minimum 99%, Missing); hippocampal formation: 96.3303% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); kidney: 98.1308% (minimum 99%, Missing); liver: 97.2222% (minimum 99%, Missing); lung: 98.1308% (minimum 99%, Missing); midbrain: 96.3303% (minimum 99%, Missing); pancreas: 94.5946% (minimum 99%, Missing); small intestine: 92.9204% (minimum 99%, Missing); smooth muscle: 91.3043% (minimum 99%, Missing); stomach: 94.5946% (minimum 97%, Missing); thyroid gland: 94.5946% (minimum 95%, Missing); urinary bladder: 92.9204% (minimum 97%, Missing)",-0.0601695,-0.0407965,-0.194545,0,80,unavailable,2.7,0.8,1.3,"heart muscle: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156466,GDF6,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.239831,0.229204,0.0454545,0,80,unavailable,2.7,0.8,1.3,"heart muscle: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156466,GDF6,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.239831,0.229204,0.0454545,0,80,unavailable,2.7,0.8,1.3,"heart muscle: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156466,GDF6,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.239831,0.229204,0.0454545,0,80,unavailable,2.7,0.8,1.3,"heart muscle: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156466,GDF6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.239831,0.229204,0.0454545,0,80,unavailable,2.7,0.8,1.3,"heart muscle: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156466,GDF6,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.4000% (minimum 90%, Approved); adrenal gland: 85.8333% (minimum 99%, Missing); amygdala: 90.3509% (minimum 99%, Missing); basal ganglia: 85.1240% (minimum 99%, Missing); bone marrow: 63.5802% (minimum 99%, Missing); cerebellum: 96.2617% (minimum 99%, Missing); cerebral cortex: 82.4000% (minimum 98%, Approved); choroid plexus: 59.1954% (minimum 99%, Missing); colon: 85.8333% (minimum 97%, Missing); duodenum: 91.9643% (minimum 99%, Missing); esophagus: 85.8333% (minimum 97%, Missing); heart muscle: 88.7931% (minimum 99%, Missing); hippocampal formation: 91.1504% (minimum 99%, Missing); hypothalamus: 90.3509% (minimum 99%, Missing); kidney: 87.2881% (minimum 99%, Missing); liver: 85.1240% (minimum 99%, Missing); lung: 83.0645% (minimum 99%, Missing); lymph node: 71.5278% (minimum 97%, Missing); midbrain: 91.1504% (minimum 99%, Missing); pancreas: 93.6364% (minimum 99%, Missing); parathyroid gland: 87.2881% (minimum 97%, Missing); pituitary gland: 87.2881% (minimum 99%, Missing); rectum: 87.2881% (minimum 97%, Missing); retina: 65.1899% (minimum 99%, Missing); salivary gland: 72.0280% (minimum 97%, Missing); skeletal muscle: 86.5546% (minimum 98%, Approved); skin: 88.0342% (minimum 95%, Missing); small intestine: 88.7931% (minimum 99%, Missing); smooth muscle: 78.0303% (minimum 98%, Approved); spinal cord: 91.1504% (minimum 99%, Missing); spleen: 72.5352% (minimum 95%, Missing); stomach: 79.2308% (minimum 97%, Missing); thymus: 71.5278% (minimum 95%, Missing); thyroid gland: 87.2881% (minimum 95%, Missing); tongue: 88.7931% (minimum 97%, Missing); urinary bladder: 84.4262% (minimum 97%, Missing)",-0.234722,-0.254722,-0.398046,0,4,partial,7.1,4.1,4.1,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); salivary gland: 4 nTPM (protected, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); stomach: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156500,PABIR3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 63.5802% (minimum 75%, Missing); choroid plexus: 59.1954% (minimum 75%, Missing); retina: 65.1899% (minimum 75%, Missing)",0.0652778,0.0152778,-0.158046,0,4,partial,7.1,4.1,4.1,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); salivary gland: 4 nTPM (protected, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); stomach: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156500,PABIR3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 63.5802% (minimum 75%, Missing); choroid plexus: 59.1954% (minimum 75%, Missing); retina: 65.1899% (minimum 75%, Missing)",0.0652778,0.0152778,-0.158046,0,4,partial,7.1,4.1,4.1,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); salivary gland: 4 nTPM (protected, limit 3); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156500,PABIR3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 63.5802% (minimum 75%, Missing); choroid plexus: 59.1954% (minimum 75%, Missing); retina: 65.1899% (minimum 75%, Missing)",0.0652778,0.0152778,-0.158046,0,4,partial,7.1,4.1,4.1,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); salivary gland: 4 nTPM (protected, limit 3); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156500,PABIR3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 63.5802% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 59.1954% (minimum 75%, Baseline (adaptation disabled)); retina: 65.1899% (minimum 75%, Baseline (adaptation disabled))",0.0652778,0.0152778,-0.158046,0,4,partial,7.1,4.1,4.1,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); salivary gland: 4 nTPM (protected, limit 3); smooth muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156500,PABIR3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 94.5946% (minimum 97%, Missing); thymus: 92.1053% (minimum 95%, Missing)",-0.0289474,-0.0240541,0.01,0,80,unavailable,0,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156509,FBXO43,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
True,compatible,,True,True,True,,0.271053,0.245946,0.25,0,80,unavailable,0,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156509,FBXO43,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
True,compatible,,True,True,True,,0.271053,0.245946,0.25,0,80,unavailable,0,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156509,FBXO43,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
True,compatible,,True,True,True,,0.271053,0.245946,0.25,0,80,unavailable,0,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156509,FBXO43,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
True,compatible,,True,True,True,,0.271053,0.245946,0.25,0,80,unavailable,0,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156509,FBXO43,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Missing); adrenal gland: 84.4156% (minimum 99%, Uncertain); amygdala: 86.6667% (minimum 99%, Missing); basal ganglia: 86.6667% (minimum 99%, Missing); bone marrow: 52.4194% (minimum 99%, Missing); cerebellum: 68.4211% (minimum 99%, Uncertain); cerebral cortex: 85.5263% (minimum 99%, Missing); choroid plexus: 97.0149% (minimum 99%, Missing); colon: 75.5814% (minimum 97%, Missing); duodenum: 70.6522% (minimum 99%, Missing); esophagus: 76.4706% (minimum 97%, Missing); heart muscle: 86.6667% (minimum 99%, Uncertain); hippocampal formation: 84.4156% (minimum 99%, Missing); hypothalamus: 86.6667% (minimum 99%, Missing); kidney: 86.6667% (minimum 99%, Missing); liver: 82.2785% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Uncertain); lymph node: 61.3208% (minimum 97%, Uncertain); midbrain: 84.4156% (minimum 99%, Missing); pancreas: 83.3333% (minimum 99%, Missing); parathyroid gland: 63.1068% (minimum 97%, Uncertain); pituitary gland: 80.2469% (minimum 99%, Missing); rectum: 69.1489% (minimum 97%, Missing); retina: 54.1667% (minimum 99%, Missing); salivary gland: 79.2683% (minimum 97%, Uncertain); skeletal muscle: 83.3333% (minimum 99%, Missing); skin: 75.5814% (minimum 95%, Missing); small intestine: 74.7126% (minimum 99%, Uncertain); smooth muscle: 79.2683% (minimum 99%, Missing); spinal cord: 77.3810% (minimum 99%, Missing); spleen: 76.4706% (minimum 95%, Uncertain); stomach: 76.4706% (minimum 97%, Missing); thymus: 60.7477% (minimum 95%, Missing); thyroid gland: 81.2500% (minimum 95%, Missing); tongue: 87.8378% (minimum 97%, Missing); urinary bladder: 82.2785% (minimum 97%, Missing)",-0.342523,-0.356792,-0.465806,0,4,partial,5.9,4.1,4.2,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156876,SASS6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 52.4194% (minimum 75%, Missing); cerebellum: 68.4211% (minimum 75%, Uncertain); duodenum: 70.6522% (minimum 75%, Missing); lymph node: 61.3208% (minimum 70%, Uncertain); parathyroid gland: 63.1068% (minimum 70%, Uncertain); rectum: 69.1489% (minimum 70%, Missing); retina: 54.1667% (minimum 75%, Missing); small intestine: 74.7126% (minimum 75%, Uncertain); thymus: 60.7477% (minimum 65%, Missing)",-0.0425234,-0.0867925,-0.225806,0,4,partial,5.9,4.1,4.2,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156876,SASS6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 52.4194% (minimum 75%, Missing); cerebellum: 68.4211% (minimum 75%, Uncertain); duodenum: 70.6522% (minimum 75%, Missing); lymph node: 61.3208% (minimum 70%, Uncertain); parathyroid gland: 63.1068% (minimum 70%, Uncertain); rectum: 69.1489% (minimum 70%, Missing); retina: 54.1667% (minimum 75%, Missing); small intestine: 74.7126% (minimum 75%, Uncertain); thymus: 60.7477% (minimum 65%, Missing)",-0.0425234,-0.0867925,-0.225806,0,4,partial,5.9,4.1,4.2,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); parathyroid gland: 3.8 nTPM (protected, limit 3); cerebellum: 3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156876,SASS6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 52.4194% (minimum 75%, Missing); cerebellum: 68.4211% (minimum 75%, Uncertain); duodenum: 70.6522% (minimum 75%, Missing); lymph node: 61.3208% (minimum 70%, Uncertain); parathyroid gland: 63.1068% (minimum 70%, Uncertain); rectum: 69.1489% (minimum 70%, Missing); retina: 54.1667% (minimum 75%, Missing); small intestine: 74.7126% (minimum 75%, Uncertain); thymus: 60.7477% (minimum 65%, Missing)",-0.0425234,-0.0867925,-0.225806,0,4,partial,5.9,4.1,4.2,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); parathyroid gland: 3.8 nTPM (protected, limit 3); cerebellum: 3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156876,SASS6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 52.4194% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.4211% (minimum 75%, Baseline (adaptation disabled)); duodenum: 70.6522% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.3208% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 63.1068% (minimum 70%, Baseline (adaptation disabled)); rectum: 69.1489% (minimum 70%, Baseline (adaptation disabled)); retina: 54.1667% (minimum 75%, Baseline (adaptation disabled)); small intestine: 74.7126% (minimum 75%, Baseline (adaptation disabled)); thymus: 60.7477% (minimum 65%, Baseline (adaptation disabled))",-0.0425234,-0.0867925,-0.225806,0,4,partial,5.9,4.1,4.2,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); parathyroid gland: 3.8 nTPM (protected, limit 3); cerebellum: 3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156876,SASS6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7376% (minimum 99%, Missing); bone marrow: 55.1020% (minimum 99%, Missing); cerebral cortex: 98.6301% (minimum 99%, Missing); choroid plexus: 63.1579% (minimum 99%, Missing); colon: 83.0769% (minimum 97%, Missing); duodenum: 82.7586% (minimum 99%, Missing); esophagus: 81.2030% (minimum 97%, Missing); heart muscle: 98.6301% (minimum 99%, Missing); kidney: 98.6301% (minimum 99%, Missing); liver: 98.1818% (minimum 99%, Missing); lung: 96.0000% (minimum 99%, Missing); lymph node: 63.7168% (minimum 97%, Missing); rectum: 78.8321% (minimum 97%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); skin: 86.4000% (minimum 95%, Missing); small intestine: 84.3750% (minimum 99%, Missing); smooth muscle: 91.5254% (minimum 99%, Missing); spleen: 87.8049% (minimum 95%, Missing); stomach: 90.3766% (minimum 97%, Missing); thymus: 38.2979% (minimum 95%, Missing); urinary bladder: 93.9130% (minimum 97%, Missing)",-0.567021,-0.332832,-0.43898,0,80,unavailable,17.6,12.3,34.8,"thymus: 34.8 nTPM (manageable, limit 5); bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156970,BUB1B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.1020% (minimum 75%, Missing); choroid plexus: 63.1579% (minimum 75%, Missing); lymph node: 63.7168% (minimum 70%, Missing); thymus: 38.2979% (minimum 65%, Missing)",-0.267021,-0.0628319,-0.19898,0,80,unavailable,17.6,12.3,34.8,"thymus: 34.8 nTPM (manageable, limit 5); bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156970,BUB1B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.1020% (minimum 75%, Missing); choroid plexus: 63.1579% (minimum 75%, Missing); lymph node: 63.7168% (minimum 70%, Missing); thymus: 38.2979% (minimum 65%, Missing)",-0.267021,-0.0628319,-0.19898,0,80,unavailable,17.6,12.3,34.8,"thymus: 34.8 nTPM (manageable, limit 5); bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156970,BUB1B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.1020% (minimum 75%, Missing); choroid plexus: 63.1579% (minimum 75%, Missing); lymph node: 63.7168% (minimum 70%, Missing); thymus: 38.2979% (minimum 65%, Missing)",-0.267021,-0.0628319,-0.19898,0,80,unavailable,17.6,12.3,34.8,"thymus: 34.8 nTPM (manageable, limit 5); bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156970,BUB1B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.1020% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 63.1579% (minimum 75%, Baseline (adaptation disabled)); lymph node: 63.7168% (minimum 70%, Baseline (adaptation disabled)); thymus: 38.2979% (minimum 65%, Baseline (adaptation disabled))",-0.267021,-0.0628319,-0.19898,0,80,unavailable,17.6,12.3,34.8,"thymus: 34.8 nTPM (manageable, limit 5); bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000156970,BUB1B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.4396% (minimum 95%, Missing); adrenal gland: 60.9694% (minimum 99%, Missing); amygdala: 52.7594% (minimum 99%, Missing); basal ganglia: 54.3182% (minimum 99%, Missing); bone marrow: 41.2781% (minimum 99%, Missing); cerebellum: 57.0406% (minimum 99%, Missing); cerebral cortex: 50.9595% (minimum 99%, Missing); choroid plexus: 69.4767% (minimum 99%, Missing); colon: 61.4396% (minimum 97%, Missing); duodenum: 66.0221% (minimum 99%, Missing); esophagus: 55.1963% (minimum 97%, Missing); heart muscle: 60.3535% (minimum 99%, Missing); hippocampal formation: 54.5662% (minimum 99%, Missing); hypothalamus: 61.7571% (minimum 99%, Missing); kidney: 58.0097% (minimum 99%, Missing); liver: 63.5638% (minimum 99%, Missing); lung: 58.7224% (minimum 99%, Missing); lymph node: 53.1111% (minimum 97%, Missing); midbrain: 62.2396% (minimum 99%, Missing); pancreas: 55.3241% (minimum 99%, Missing); parathyroid gland: 58.0097% (minimum 97%, Missing); pituitary gland: 58.0097% (minimum 99%, Missing); rectum: 62.7297% (minimum 97%, Missing); retina: 73.3129% (minimum 99%, Missing); salivary gland: 58.1509% (minimum 97%, Missing); skeletal muscle: 62.4021% (minimum 99%, Missing); skin: 54.4419% (minimum 95%, Missing); small intestine: 56.6351% (minimum 99%, Missing); smooth muscle: 64.7696% (minimum 99%, Missing); spinal cord: 62.0779% (minimum 99%, Missing); spleen: 50.6356% (minimum 95%, Missing); stomach: 59.6010% (minimum 97%, Missing); thymus: 42.9856% (minimum 95%, Missing); thyroid gland: 54.1950% (minimum 95%, Missing); tongue: 69.6793% (minimum 97%, Missing); urinary bladder: 59.8997% (minimum 97%, Missing)",-0.520144,-0.438889,-0.577219,0,2,partial,34,21.1,31.7,"bone marrow: 34 nTPM (vital, limit 1); thymus: 31.7 nTPM (manageable, limit 5); spleen: 23.3 nTPM (manageable, limit 5); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 2); thyroid gland: 20.2 nTPM (manageable, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); skin: 20 nTPM (manageable, limit 5); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 2); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 2); kidney: 17.3 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 2); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 2); urinary bladder: 16 nTPM (protected, limit 2); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); colon: 15 nTPM (protected, limit 2); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 2); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 2); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157014,TATDN2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.4396% (minimum 65%, Missing); adrenal gland: 60.9694% (minimum 75%, Missing); amygdala: 52.7594% (minimum 75%, Missing); basal ganglia: 54.3182% (minimum 75%, Missing); bone marrow: 41.2781% (minimum 75%, Missing); cerebellum: 57.0406% (minimum 75%, Missing); cerebral cortex: 50.9595% (minimum 75%, Missing); choroid plexus: 69.4767% (minimum 75%, Missing); colon: 61.4396% (minimum 70%, Missing); duodenum: 66.0221% (minimum 75%, Missing); esophagus: 55.1963% (minimum 70%, Missing); heart muscle: 60.3535% (minimum 75%, Missing); hippocampal formation: 54.5662% (minimum 75%, Missing); hypothalamus: 61.7571% (minimum 75%, Missing); kidney: 58.0097% (minimum 75%, Missing); liver: 63.5638% (minimum 75%, Missing); lung: 58.7224% (minimum 75%, Missing); lymph node: 53.1111% (minimum 70%, Missing); midbrain: 62.2396% (minimum 75%, Missing); pancreas: 55.3241% (minimum 75%, Missing); parathyroid gland: 58.0097% (minimum 70%, Missing); pituitary gland: 58.0097% (minimum 75%, Missing); rectum: 62.7297% (minimum 70%, Missing); retina: 73.3129% (minimum 75%, Missing); salivary gland: 58.1509% (minimum 70%, Missing); skeletal muscle: 62.4021% (minimum 75%, Missing); skin: 54.4419% (minimum 65%, Missing); small intestine: 56.6351% (minimum 75%, Missing); smooth muscle: 64.7696% (minimum 75%, Missing); spinal cord: 62.0779% (minimum 75%, Missing); spleen: 50.6356% (minimum 65%, Missing); stomach: 59.6010% (minimum 70%, Missing); thymus: 42.9856% (minimum 65%, Missing); thyroid gland: 54.1950% (minimum 65%, Missing); tongue: 69.6793% (minimum 70%, Missing); urinary bladder: 59.8997% (minimum 70%, Missing)",-0.220144,-0.168889,-0.337219,0,2,partial,34,21.1,31.7,"bone marrow: 34 nTPM (vital, limit 1); thymus: 31.7 nTPM (manageable, limit 5); spleen: 23.3 nTPM (manageable, limit 5); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 2); thyroid gland: 20.2 nTPM (manageable, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); skin: 20 nTPM (manageable, limit 5); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 2); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 2); kidney: 17.3 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 2); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 2); urinary bladder: 16 nTPM (protected, limit 2); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); colon: 15 nTPM (protected, limit 2); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 2); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 2); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157014,TATDN2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.4396% (minimum 65%, Missing); adrenal gland: 60.9694% (minimum 75%, Missing); amygdala: 52.7594% (minimum 75%, Missing); basal ganglia: 54.3182% (minimum 75%, Missing); bone marrow: 41.2781% (minimum 75%, Missing); cerebellum: 57.0406% (minimum 75%, Missing); cerebral cortex: 50.9595% (minimum 75%, Missing); choroid plexus: 69.4767% (minimum 75%, Missing); colon: 61.4396% (minimum 70%, Missing); duodenum: 66.0221% (minimum 75%, Missing); esophagus: 55.1963% (minimum 70%, Missing); heart muscle: 60.3535% (minimum 75%, Missing); hippocampal formation: 54.5662% (minimum 75%, Missing); hypothalamus: 61.7571% (minimum 75%, Missing); kidney: 58.0097% (minimum 75%, Missing); liver: 63.5638% (minimum 75%, Missing); lung: 58.7224% (minimum 75%, Missing); lymph node: 53.1111% (minimum 70%, Missing); midbrain: 62.2396% (minimum 75%, Missing); pancreas: 55.3241% (minimum 75%, Missing); parathyroid gland: 58.0097% (minimum 70%, Missing); pituitary gland: 58.0097% (minimum 75%, Missing); rectum: 62.7297% (minimum 70%, Missing); retina: 73.3129% (minimum 75%, Missing); salivary gland: 58.1509% (minimum 70%, Missing); skeletal muscle: 62.4021% (minimum 75%, Missing); skin: 54.4419% (minimum 65%, Missing); small intestine: 56.6351% (minimum 75%, Missing); smooth muscle: 64.7696% (minimum 75%, Missing); spinal cord: 62.0779% (minimum 75%, Missing); spleen: 50.6356% (minimum 65%, Missing); stomach: 59.6010% (minimum 70%, Missing); thymus: 42.9856% (minimum 65%, Missing); thyroid gland: 54.1950% (minimum 65%, Missing); tongue: 69.6793% (minimum 70%, Missing); urinary bladder: 59.8997% (minimum 70%, Missing)",-0.220144,-0.168889,-0.337219,0,2,partial,34,21.1,31.7,"bone marrow: 34 nTPM (vital, limit 1); thymus: 31.7 nTPM (manageable, limit 5); spleen: 23.3 nTPM (manageable, limit 5); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 3); thyroid gland: 20.2 nTPM (manageable, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); skin: 20 nTPM (manageable, limit 5); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 3); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 3); kidney: 17.3 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 3); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 3); urinary bladder: 16 nTPM (protected, limit 3); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); colon: 15 nTPM (protected, limit 3); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 3); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 3); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157014,TATDN2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.4396% (minimum 65%, Missing); adrenal gland: 60.9694% (minimum 75%, Missing); amygdala: 52.7594% (minimum 75%, Missing); basal ganglia: 54.3182% (minimum 75%, Missing); bone marrow: 41.2781% (minimum 75%, Missing); cerebellum: 57.0406% (minimum 75%, Missing); cerebral cortex: 50.9595% (minimum 75%, Missing); choroid plexus: 69.4767% (minimum 75%, Missing); colon: 61.4396% (minimum 70%, Missing); duodenum: 66.0221% (minimum 75%, Missing); esophagus: 55.1963% (minimum 70%, Missing); heart muscle: 60.3535% (minimum 75%, Missing); hippocampal formation: 54.5662% (minimum 75%, Missing); hypothalamus: 61.7571% (minimum 75%, Missing); kidney: 58.0097% (minimum 75%, Missing); liver: 63.5638% (minimum 75%, Missing); lung: 58.7224% (minimum 75%, Missing); lymph node: 53.1111% (minimum 70%, Missing); midbrain: 62.2396% (minimum 75%, Missing); pancreas: 55.3241% (minimum 75%, Missing); parathyroid gland: 58.0097% (minimum 70%, Missing); pituitary gland: 58.0097% (minimum 75%, Missing); rectum: 62.7297% (minimum 70%, Missing); retina: 73.3129% (minimum 75%, Missing); salivary gland: 58.1509% (minimum 70%, Missing); skeletal muscle: 62.4021% (minimum 75%, Missing); skin: 54.4419% (minimum 65%, Missing); small intestine: 56.6351% (minimum 75%, Missing); smooth muscle: 64.7696% (minimum 75%, Missing); spinal cord: 62.0779% (minimum 75%, Missing); spleen: 50.6356% (minimum 65%, Missing); stomach: 59.6010% (minimum 70%, Missing); thymus: 42.9856% (minimum 65%, Missing); thyroid gland: 54.1950% (minimum 65%, Missing); tongue: 69.6793% (minimum 70%, Missing); urinary bladder: 59.8997% (minimum 70%, Missing)",-0.220144,-0.168889,-0.337219,0,2,partial,34,21.1,31.7,"bone marrow: 34 nTPM (vital, limit 1); thymus: 31.7 nTPM (manageable, limit 5); spleen: 23.3 nTPM (manageable, limit 5); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 3); thyroid gland: 20.2 nTPM (manageable, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); skin: 20 nTPM (manageable, limit 5); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 3); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 3); kidney: 17.3 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 3); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 3); urinary bladder: 16 nTPM (protected, limit 3); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); colon: 15 nTPM (protected, limit 3); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 3); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 3); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157014,TATDN2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.4396% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.9694% (minimum 75%, Baseline (adaptation disabled)); amygdala: 52.7594% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.3182% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 41.2781% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.0406% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.9595% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.4767% (minimum 75%, Baseline (adaptation disabled)); colon: 61.4396% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.0221% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.1963% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.3535% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.5662% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.7571% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.0097% (minimum 75%, Baseline (adaptation disabled)); liver: 63.5638% (minimum 75%, Baseline (adaptation disabled)); lung: 58.7224% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.1111% (minimum 70%, Baseline (adaptation disabled)); midbrain: 62.2396% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.3241% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.0097% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.0097% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.7297% (minimum 70%, Baseline (adaptation disabled)); retina: 73.3129% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.1509% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 62.4021% (minimum 75%, Baseline (adaptation disabled)); skin: 54.4419% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.6351% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.7696% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.0779% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.6356% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.6010% (minimum 70%, Baseline (adaptation disabled)); thymus: 42.9856% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.1950% (minimum 65%, Baseline (adaptation disabled)); tongue: 69.6793% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 59.8997% (minimum 70%, Baseline (adaptation disabled))",-0.220144,-0.168889,-0.337219,0,2,partial,34,21.1,31.7,"bone marrow: 34 nTPM (vital, limit 1); thymus: 31.7 nTPM (manageable, limit 5); spleen: 23.3 nTPM (manageable, limit 5); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 3); thyroid gland: 20.2 nTPM (manageable, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); skin: 20 nTPM (manageable, limit 5); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 3); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 3); kidney: 17.3 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 3); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 3); urinary bladder: 16 nTPM (protected, limit 3); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); colon: 15 nTPM (protected, limit 3); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 3); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 3); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157014,TATDN2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,kidney / distal tubules: Medium (Enhanced),58,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157060,SHCBP1L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,kidney / distal tubules: Medium (Enhanced),58,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157060,SHCBP1L,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,kidney / distal tubules: Medium (Enhanced),58,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157060,SHCBP1L,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,kidney / distal tubules: Medium (Enhanced),58,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157060,SHCBP1L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,kidney / distal tubules: Medium (Enhanced),58,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157060,SHCBP1L,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.0658% (minimum 99%, Missing)",0.05,0.03,-0.00934236,0,1,partial,1,0,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157093,LYZL4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.230658,0,1,partial,1,0,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157093,LYZL4,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.230658,0,1,partial,1,0,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157093,LYZL4,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.230658,0,1,partial,1,0,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157093,LYZL4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348031,0.3,0.230658,0,1,partial,1,0,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157093,LYZL4,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.6709% (minimum 95%, Uncertain); adrenal gland: 87.0588% (minimum 99%, Uncertain); amygdala: 71.8447% (minimum 99%, Missing); basal ganglia: 80.4348% (minimum 99%, Missing); bone marrow: 85.0575% (minimum 99%, Missing); cerebellum: 68.5185% (minimum 99%, Missing); cerebral cortex: 57.3643% (minimum 99%, Missing); choroid plexus: 71.1538% (minimum 99%, Missing); colon: 72.5490% (minimum 97%, Uncertain); duodenum: 77.8947% (minimum 99%, Uncertain); esophagus: 74.0000% (minimum 97%, Uncertain); heart muscle: 80.4348% (minimum 99%, Uncertain); hippocampal formation: 77.8947% (minimum 99%, Missing); hypothalamus: 38.7435% (minimum 99%, Missing); kidney: 48.0519% (minimum 99%, Uncertain); liver: 30.9623% (minimum 99%, Uncertain); lung: 68.5185% (minimum 99%, Uncertain); lymph node: 96.1039% (minimum 97%, Missing); midbrain: 63.7931% (minimum 99%, Missing); pancreas: 92.5000% (minimum 99%, Uncertain); parathyroid gland: 92.5000% (minimum 97%, Missing); pituitary gland: 67.2727% (minimum 99%, Missing); rectum: 71.8447% (minimum 97%, Uncertain); retina: 39.5722% (minimum 99%, Missing); salivary gland: 74.7475% (minimum 97%, Uncertain); skeletal muscle: 98.6667% (minimum 99%, Uncertain); skin: 61.1570% (minimum 95%, Missing); small intestine: 76.2887% (minimum 99%, Uncertain); smooth muscle: 88.0952% (minimum 99%, Uncertain); spinal cord: 78.7234% (minimum 99%, Missing); spleen: 83.1461% (minimum 95%, Missing); stomach: 77.8947% (minimum 97%, Uncertain); thymus: 90.2439% (minimum 95%, Missing); thyroid gland: 44.0476% (minimum 95%, Uncertain); urinary bladder: 45.3988% (minimum 97%, Uncertain)",-0.509524,-0.516012,-0.680377,0,2,partial,16.5,8.9,9.4,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 2); kidney: 8 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157168,NRG1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 71.8447% (minimum 75%, Missing); cerebellum: 68.5185% (minimum 75%, Missing); cerebral cortex: 57.3643% (minimum 75%, Missing); choroid plexus: 71.1538% (minimum 75%, Missing); hypothalamus: 38.7435% (minimum 75%, Missing); kidney: 48.0519% (minimum 75%, Uncertain); liver: 30.9623% (minimum 75%, Uncertain); lung: 68.5185% (minimum 75%, Uncertain); midbrain: 63.7931% (minimum 75%, Missing); pituitary gland: 67.2727% (minimum 75%, Missing); retina: 39.5722% (minimum 75%, Missing); skin: 61.1570% (minimum 65%, Missing); thyroid gland: 44.0476% (minimum 65%, Uncertain); urinary bladder: 45.3988% (minimum 70%, Uncertain)",-0.209524,-0.246012,-0.440377,0,2,partial,16.5,8.9,9.4,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 2); kidney: 8 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157168,NRG1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 71.8447% (minimum 75%, Missing); cerebellum: 68.5185% (minimum 75%, Missing); cerebral cortex: 57.3643% (minimum 75%, Missing); choroid plexus: 71.1538% (minimum 75%, Missing); hypothalamus: 38.7435% (minimum 75%, Missing); kidney: 48.0519% (minimum 75%, Uncertain); liver: 30.9623% (minimum 75%, Uncertain); lung: 68.5185% (minimum 75%, Uncertain); midbrain: 63.7931% (minimum 75%, Missing); pituitary gland: 67.2727% (minimum 75%, Missing); retina: 39.5722% (minimum 75%, Missing); skin: 61.1570% (minimum 65%, Missing); thyroid gland: 44.0476% (minimum 65%, Uncertain); urinary bladder: 45.3988% (minimum 70%, Uncertain)",-0.209524,-0.246012,-0.440377,0,2,partial,16.5,8.9,9.4,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 3); kidney: 8 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157168,NRG1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 71.8447% (minimum 75%, Missing); cerebellum: 68.5185% (minimum 75%, Missing); cerebral cortex: 57.3643% (minimum 75%, Missing); choroid plexus: 71.1538% (minimum 75%, Missing); hypothalamus: 38.7435% (minimum 75%, Missing); kidney: 48.0519% (minimum 75%, Uncertain); liver: 30.9623% (minimum 75%, Uncertain); lung: 68.5185% (minimum 75%, Uncertain); midbrain: 63.7931% (minimum 75%, Missing); pituitary gland: 67.2727% (minimum 75%, Missing); retina: 39.5722% (minimum 75%, Missing); skin: 61.1570% (minimum 65%, Missing); thyroid gland: 44.0476% (minimum 65%, Uncertain); urinary bladder: 45.3988% (minimum 70%, Uncertain)",-0.209524,-0.246012,-0.440377,0,2,partial,16.5,8.9,9.4,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 3); kidney: 8 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157168,NRG1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 71.8447% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.5185% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.3643% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 71.1538% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 38.7435% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.0519% (minimum 75%, Baseline (adaptation disabled)); liver: 30.9623% (minimum 75%, Baseline (adaptation disabled)); lung: 68.5185% (minimum 75%, Baseline (adaptation disabled)); midbrain: 63.7931% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 67.2727% (minimum 75%, Baseline (adaptation disabled)); retina: 39.5722% (minimum 75%, Baseline (adaptation disabled)); skin: 61.1570% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 44.0476% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 45.3988% (minimum 70%, Baseline (adaptation disabled))",-0.209524,-0.246012,-0.440377,0,2,partial,16.5,8.9,9.4,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 3); kidney: 8 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157168,NRG1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.9394% (minimum 95%, Missing); adrenal gland: 77.5000% (minimum 99%, Missing); amygdala: 91.1765% (minimum 99%, Missing); basal ganglia: 79.4872% (minimum 99%, Missing); bone marrow: 88.5714% (minimum 99%, Missing); cerebellum: 96.8750% (minimum 99%, Missing); cerebral cortex: 88.5714% (minimum 99%, Missing); choroid plexus: 16.3158% (minimum 99%, Missing); colon: 88.5714% (minimum 97%, Missing); duodenum: 96.8750% (minimum 99%, Missing); esophagus: 96.8750% (minimum 97%, Missing); heart muscle: 96.8750% (minimum 99%, Missing); hippocampal formation: 88.5714% (minimum 99%, Missing); hypothalamus: 83.7838% (minimum 99%, Missing); kidney: 11.7871% (minimum 99%, Missing); liver: 93.9394% (minimum 99%, Missing); lung: 88.5714% (minimum 99%, Missing); lymph node: 93.9394% (minimum 97%, Missing); midbrain: 88.5714% (minimum 99%, Missing); pancreas: 88.5714% (minimum 99%, Missing); parathyroid gland: 96.8750% (minimum 97%, Missing); pituitary gland: 88.5714% (minimum 99%, Missing); rectum: 96.8750% (minimum 97%, Missing); retina: 96.8750% (minimum 99%, Missing); salivary gland: 83.7838% (minimum 97%, Missing); skeletal muscle: 93.9394% (minimum 99%, Missing); skin: 91.1765% (minimum 95%, Missing); small intestine: 81.5789% (minimum 99%, Missing); spinal cord: 73.8095% (minimum 99%, Missing); spleen: 72.0930% (minimum 95%, Missing); stomach: 86.1111% (minimum 97%, Missing); thymus: 93.9394% (minimum 95%, Missing); thyroid gland: 88.5714% (minimum 95%, Missing); urinary bladder: 91.1765% (minimum 97%, Missing)",-0.22907,-0.132162,-0.872129,0,80,unavailable,23.2,0.6,1.2,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157322,CLEC18A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 16.3158% (minimum 75%, Missing); kidney: 11.7871% (minimum 75%, Missing); spinal cord: 73.8095% (minimum 75%, Missing)",0.0709302,0.137838,-0.632129,0,80,unavailable,23.2,0.6,1.2,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157322,CLEC18A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 16.3158% (minimum 75%, Missing); kidney: 11.7871% (minimum 75%, Missing); spinal cord: 73.8095% (minimum 75%, Missing)",0.0709302,0.137838,-0.632129,0,80,unavailable,23.2,0.6,1.2,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157322,CLEC18A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 16.3158% (minimum 75%, Missing); kidney: 11.7871% (minimum 75%, Missing); spinal cord: 73.8095% (minimum 75%, Missing)",0.0709302,0.137838,-0.632129,0,80,unavailable,23.2,0.6,1.2,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157322,CLEC18A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 16.3158% (minimum 75%, Baseline (adaptation disabled)); kidney: 11.7871% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.8095% (minimum 75%, Baseline (adaptation disabled))",0.0709302,0.137838,-0.632129,0,80,unavailable,23.2,0.6,1.2,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157322,CLEC18A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.9381% (minimum 99%, Missing); basal ganglia: 95.7661% (minimum 99%, Missing); choroid plexus: 51.1853% (minimum 99%, Missing); hippocampal formation: 96.3489% (minimum 99%, Missing); hypothalamus: 94.8104% (minimum 99%, Missing); lung: 96.3489% (minimum 99%, Missing); pituitary gland: 98.7526% (minimum 99%, Missing); skeletal muscle: 97.5359% (minimum 99%, Missing)",0.037526,0.0278992,-0.478147,0,80,unavailable,45.3,0.1,0.6,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157330,CFAP107,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 51.1853% (minimum 75%, Missing)",0.337526,0.297899,-0.238147,0,80,unavailable,45.3,0.1,0.6,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157330,CFAP107,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 51.1853% (minimum 75%, Missing)",0.337526,0.297899,-0.238147,0,80,unavailable,45.3,0.1,0.6,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157330,CFAP107,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 51.1853% (minimum 75%, Missing)",0.337526,0.297899,-0.238147,0,80,unavailable,45.3,0.1,0.6,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157330,CFAP107,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 51.1853% (minimum 75%, Baseline (adaptation disabled))",0.337526,0.297899,-0.238147,0,80,unavailable,45.3,0.1,0.6,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157330,CFAP107,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.7055% (minimum 99%, Missing); basal ganglia: 94.5455% (minimum 99%, Missing); choroid plexus: 92.0354% (minimum 99%, Missing); hippocampal formation: 96.4451% (minimum 99%, Missing); hypothalamus: 95.7055% (minimum 99%, Missing); liver: 93.4132% (minimum 95%, Enhanced); midbrain: 96.5944% (minimum 99%, Missing); pituitary gland: 85.1296% (minimum 99%, Missing); retina: 97.9592% (minimum 99%, Missing); spinal cord: 96.8944% (minimum 99%, Missing)",0.00558959,0.00805643,-0.138704,0,3,partial,10.9,1.4,2.9,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157343,ARMC12,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.30559,0.278056,0.101296,0,3,partial,10.9,1.4,2.9,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157343,ARMC12,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.30559,0.278056,0.101296,0,3,partial,10.9,1.4,2.9,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157343,ARMC12,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.30559,0.278056,0.101296,0,3,partial,10.9,1.4,2.9,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157343,ARMC12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.30559,0.278056,0.101296,0,3,partial,10.9,1.4,2.9,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157343,ARMC12,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.5455% (minimum 95%, Enhanced); amygdala: 81.2500% (minimum 99%, Missing); basal ganglia: 73.2394% (minimum 99%, Missing); bone marrow: 91.2281% (minimum 95%, Enhanced); cerebellum: 82.5397% (minimum 95%, Enhanced); cerebral cortex: 81.2500% (minimum 95%, Enhanced); choroid plexus: 61.9048% (minimum 99%, Missing); colon: 89.6552% (minimum 97%, Missing); duodenum: 96.2963% (minimum 99%, Missing); heart muscle: 91.2281% (minimum 95%, Enhanced); hippocampal formation: 74.2857% (minimum 99%, Missing); hypothalamus: 71.2329% (minimum 99%, Missing); kidney: 80.0000% (minimum 95%, Enhanced); liver: 92.8571% (minimum 95%, Enhanced); lung: 78.7879% (minimum 95%, Enhanced); lymph node: 96.2963% (minimum 97%, Missing); midbrain: 83.8710% (minimum 99%, Missing); pancreas: 88.1356% (minimum 95%, Enhanced); parathyroid gland: 68.4211% (minimum 80%, Enhanced); pituitary gland: 55.3191% (minimum 99%, Missing); retina: 44.0678% (minimum 99%, Missing); small intestine: 96.2963% (minimum 99%, Missing); spinal cord: 81.2500% (minimum 99%, Missing)",0.0311321,-0.115789,-0.549322,0,13,partial,6.6,2.4,1.8,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157423,HYDIN,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 73.2394% (minimum 75%, Missing); choroid plexus: 61.9048% (minimum 75%, Missing); hippocampal formation: 74.2857% (minimum 75%, Missing); hypothalamus: 71.2329% (minimum 75%, Missing); pituitary gland: 55.3191% (minimum 75%, Missing); retina: 44.0678% (minimum 75%, Missing)",0.242857,0.134211,-0.309322,0,13,partial,6.6,2.4,1.8,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157423,HYDIN,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 73.2394% (minimum 75%, Missing); choroid plexus: 61.9048% (minimum 75%, Missing); hippocampal formation: 74.2857% (minimum 75%, Missing); hypothalamus: 71.2329% (minimum 75%, Missing); pituitary gland: 55.3191% (minimum 75%, Missing); retina: 44.0678% (minimum 75%, Missing)",0.242857,0.134211,-0.309322,0,13,partial,6.6,2.4,1.8,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157423,HYDIN,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 73.2394% (minimum 75%, Missing); choroid plexus: 61.9048% (minimum 75%, Missing); hippocampal formation: 74.2857% (minimum 75%, Missing); hypothalamus: 71.2329% (minimum 75%, Missing); pituitary gland: 55.3191% (minimum 75%, Missing); retina: 44.0678% (minimum 75%, Missing)",0.242857,0.134211,-0.309322,0,13,partial,6.6,2.4,1.8,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157423,HYDIN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 73.2394% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 61.9048% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.2857% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.2329% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 68.4211% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.3191% (minimum 75%, Baseline (adaptation disabled)); retina: 44.0678% (minimum 75%, Baseline (adaptation disabled))",0.0928571,-0.0157895,-0.309322,0,13,partial,6.6,2.4,1.8,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157423,HYDIN,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.8877% (minimum 90%, Approved); adrenal gland: 85.1648% (minimum 99%, Missing); amygdala: 92.8144% (minimum 99%, Missing); basal ganglia: 91.1765% (minimum 99%, Missing); bone marrow: 85.6354% (minimum 98%, Approved); cerebellum: 94.5122% (minimum 99%, Missing); cerebral cortex: 77.1144% (minimum 98%, Approved); choroid plexus: 63.2653% (minimum 99%, Missing); colon: 87.0787% (minimum 97%, Missing); duodenum: 81.1518% (minimum 99%, Missing); esophagus: 78.6802% (minimum 97%, Missing); heart muscle: 79.0816% (minimum 99%, Missing); hippocampal formation: 92.2619% (minimum 99%, Missing); hypothalamus: 91.1765% (minimum 99%, Missing); kidney: 82.0106% (minimum 99%, Missing); liver: 88.0682% (minimum 99%, Missing); lung: 78.6802% (minimum 99%, Missing); lymph node: 84.2391% (minimum 97%, Missing); midbrain: 93.9394% (minimum 99%, Missing); pancreas: 72.0930% (minimum 99%, Missing); parathyroid gland: 78.6802% (minimum 97%, Missing); pituitary gland: 74.8792% (minimum 99%, Missing); rectum: 88.5714% (minimum 97%, Missing); retina: 59.3870% (minimum 99%, Missing); salivary gland: 82.4468% (minimum 97%, Missing); skeletal muscle: 62.5000% (minimum 98%, Approved); skin: 71.4286% (minimum 95%, Missing); small intestine: 84.2391% (minimum 99%, Missing); smooth muscle: 91.1765% (minimum 98%, Approved); spinal cord: 93.3735% (minimum 99%, Missing); spleen: 85.1648% (minimum 95%, Missing); stomach: 85.1648% (minimum 97%, Missing); thymus: 93.9394% (minimum 95%, Missing); thyroid gland: 66.5236% (minimum 95%, Missing); tongue: 90.1163% (minimum 97%, Missing); urinary bladder: 90.6433% (minimum 97%, Missing)",-0.284764,-0.183198,-0.39613,0,5,partial,10.6,4.2,7.8,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 2); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); skin: 6.2 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); lung: 4.2 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); stomach: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 2); colon: 2.3 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157429,ZNF19,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.2653% (minimum 75%, Missing); pancreas: 72.0930% (minimum 75%, Missing); pituitary gland: 74.8792% (minimum 75%, Missing); retina: 59.3870% (minimum 75%, Missing); skeletal muscle: 62.5000% (minimum 70%, Approved)",0.0152361,0.086802,-0.15613,0,5,partial,10.6,4.2,7.8,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 2); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); skin: 6.2 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); lung: 4.2 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); stomach: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 2); colon: 2.3 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157429,ZNF19,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.2653% (minimum 75%, Missing); pancreas: 72.0930% (minimum 75%, Missing); pituitary gland: 74.8792% (minimum 75%, Missing); retina: 59.3870% (minimum 75%, Missing); skeletal muscle: 62.5000% (minimum 70%, Approved)",0.0152361,0.086802,-0.15613,0,5,partial,10.6,4.2,7.8,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 2); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); skin: 6.2 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); esophagus: 4.2 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157429,ZNF19,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.2653% (minimum 75%, Missing); pancreas: 72.0930% (minimum 75%, Missing); pituitary gland: 74.8792% (minimum 75%, Missing); retina: 59.3870% (minimum 75%, Missing); skeletal muscle: 62.5000% (minimum 70%, Approved)",0.0152361,0.086802,-0.15613,0,5,partial,10.6,4.2,7.8,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 2); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); skin: 6.2 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); esophagus: 4.2 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157429,ZNF19,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.2653% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.0930% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 74.8792% (minimum 75%, Baseline (adaptation disabled)); retina: 59.3870% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled))",0.0152361,0.086802,-0.15613,0,5,partial,10.6,4.2,7.8,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); skin: 6.2 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157429,ZNF19,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.8889% (minimum 95%, Missing); adrenal gland: 28.5714% (minimum 99%, Missing); amygdala: 33.3333% (minimum 99%, Missing); basal ganglia: 8.9888% (minimum 99%, Missing); cerebellum: 42.1053% (minimum 99%, Missing); cerebral cortex: 9.0909% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 72.7273% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); esophagus: 76.1905% (minimum 97%, Missing); heart muscle: 39.0244% (minimum 99%, Missing); hippocampal formation: 17.3913% (minimum 99%, Missing); hypothalamus: 19.0476% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); lung: 76.1905% (minimum 99%, Missing); lymph node: 76.1905% (minimum 97%, Missing); midbrain: 41.0256% (minimum 99%, Missing); parathyroid gland: 84.2105% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 84.2105% (minimum 97%, Missing); retina: 36.3636% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 14.4144% (minimum 99%, Missing); skin: 94.1176% (minimum 95%, Missing); small intestine: 84.2105% (minimum 99%, Missing); smooth muscle: 72.7273% (minimum 99%, Missing); spinal cord: 61.5385% (minimum 99%, Missing); spleen: 88.8889% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thymus: 94.1176% (minimum 95%, Missing); thyroid gland: 80.0000% (minimum 95%, Missing); tongue: 13.4454% (minimum 97%, Missing); urinary bladder: 94.1176% (minimum 97%, Missing)",-0.15,-0.835546,-0.900112,0,80,unavailable,16.2,10.3,0.4,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 2); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157445,CACNA2D3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 28.5714% (minimum 75%, Missing); amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 8.9888% (minimum 75%, Missing); cerebellum: 42.1053% (minimum 75%, Missing); cerebral cortex: 9.0909% (minimum 75%, Missing); heart muscle: 39.0244% (minimum 75%, Missing); hippocampal formation: 17.3913% (minimum 75%, Missing); hypothalamus: 19.0476% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); midbrain: 41.0256% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 36.3636% (minimum 75%, Missing); skeletal muscle: 14.4144% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing); tongue: 13.4454% (minimum 70%, Missing)",0.15,-0.565546,-0.660112,0,80,unavailable,16.2,10.3,0.4,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 2); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157445,CACNA2D3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 28.5714% (minimum 75%, Missing); amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 8.9888% (minimum 75%, Missing); cerebellum: 42.1053% (minimum 75%, Missing); cerebral cortex: 9.0909% (minimum 75%, Missing); heart muscle: 39.0244% (minimum 75%, Missing); hippocampal formation: 17.3913% (minimum 75%, Missing); hypothalamus: 19.0476% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); midbrain: 41.0256% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 36.3636% (minimum 75%, Missing); skeletal muscle: 14.4144% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing); tongue: 13.4454% (minimum 70%, Missing)",0.15,-0.565546,-0.660112,0,80,unavailable,16.2,10.3,0.4,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 3); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157445,CACNA2D3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 28.5714% (minimum 75%, Missing); amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 8.9888% (minimum 75%, Missing); cerebellum: 42.1053% (minimum 75%, Missing); cerebral cortex: 9.0909% (minimum 75%, Missing); heart muscle: 39.0244% (minimum 75%, Missing); hippocampal formation: 17.3913% (minimum 75%, Missing); hypothalamus: 19.0476% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); midbrain: 41.0256% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 36.3636% (minimum 75%, Missing); skeletal muscle: 14.4144% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing); tongue: 13.4454% (minimum 70%, Missing)",0.15,-0.565546,-0.660112,0,80,unavailable,16.2,10.3,0.4,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 3); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157445,CACNA2D3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 28.5714% (minimum 75%, Baseline (adaptation disabled)); amygdala: 33.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 8.9888% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 42.1053% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 9.0909% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 39.0244% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 17.3913% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 19.0476% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 75%, Baseline (adaptation disabled)); midbrain: 41.0256% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 36.3636% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 14.4144% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.7273% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.5385% (minimum 75%, Baseline (adaptation disabled)); tongue: 13.4454% (minimum 70%, Baseline (adaptation disabled))",0.15,-0.565546,-0.660112,0,80,unavailable,16.2,10.3,0.4,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 3); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157445,CACNA2D3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.5380% (minimum 99%, Missing); bone marrow: 47.8014% (minimum 99%, Missing); cerebral cortex: 98.6823% (minimum 99%, Missing); colon: 83.0049% (minimum 97%, Missing); duodenum: 83.1073% (minimum 99%, Missing); esophagus: 81.1071% (minimum 97%, Missing); kidney: 98.3942% (minimum 99%, Missing); lymph node: 67.6707% (minimum 97%, Missing); pancreas: 98.9721% (minimum 99%, Missing); rectum: 80.5257% (minimum 97%, Missing); skin: 87.9896% (minimum 95%, Missing); small intestine: 85.2086% (minimum 99%, Missing); smooth muscle: 91.5761% (minimum 99%, Missing); spleen: 90.7133% (minimum 95%, Missing); stomach: 92.5824% (minimum 97%, Missing); thymus: 48.6291% (minimum 95%, Missing); urinary bladder: 95.0635% (minimum 97%, Missing)",-0.463709,-0.293293,-0.511986,0,12,partial,73.6,32.2,71.2,"bone marrow: 73.6 nTPM (vital, limit 1); thymus: 71.2 nTPM (manageable, limit 5); lymph node: 32.2 nTPM (protected, limit 2); rectum: 16.3 nTPM (protected, limit 2); esophagus: 15.7 nTPM (protected, limit 2); colon: 13.8 nTPM (protected, limit 2); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 11.7 nTPM (vital, limit 1); skin: 9.2 nTPM (manageable, limit 5); spleen: 6.9 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / eccrine glands: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),91,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / eccrine glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157456,CCNB2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 47.8014% (minimum 75%, Missing); lymph node: 67.6707% (minimum 70%, Missing); thymus: 48.6291% (minimum 65%, Missing)",-0.163709,-0.0232932,-0.271986,0,12,partial,73.6,32.2,71.2,"bone marrow: 73.6 nTPM (vital, limit 1); thymus: 71.2 nTPM (manageable, limit 5); lymph node: 32.2 nTPM (protected, limit 2); rectum: 16.3 nTPM (protected, limit 2); esophagus: 15.7 nTPM (protected, limit 2); colon: 13.8 nTPM (protected, limit 2); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 11.7 nTPM (vital, limit 1); skin: 9.2 nTPM (manageable, limit 5); spleen: 6.9 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / eccrine glands: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),91,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / eccrine glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157456,CCNB2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 47.8014% (minimum 75%, Missing); lymph node: 67.6707% (minimum 70%, Missing); thymus: 48.6291% (minimum 65%, Missing)",-0.163709,-0.0232932,-0.271986,0,12,partial,73.6,32.2,71.2,"bone marrow: 73.6 nTPM (vital, limit 1); thymus: 71.2 nTPM (manageable, limit 5); lymph node: 32.2 nTPM (protected, limit 3); rectum: 16.3 nTPM (protected, limit 3); esophagus: 15.7 nTPM (protected, limit 3); colon: 13.8 nTPM (protected, limit 3); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 11.7 nTPM (vital, limit 1); skin: 9.2 nTPM (manageable, limit 5); spleen: 6.9 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / eccrine glands: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),91,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / eccrine glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157456,CCNB2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 47.8014% (minimum 75%, Missing); lymph node: 67.6707% (minimum 70%, Missing); thymus: 48.6291% (minimum 65%, Missing)",-0.163709,-0.0232932,-0.271986,0,12,partial,73.6,32.2,71.2,"bone marrow: 73.6 nTPM (vital, limit 1); thymus: 71.2 nTPM (manageable, limit 5); lymph node: 32.2 nTPM (protected, limit 3); rectum: 16.3 nTPM (protected, limit 3); esophagus: 15.7 nTPM (protected, limit 3); colon: 13.8 nTPM (protected, limit 3); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 11.7 nTPM (vital, limit 1); skin: 9.2 nTPM (manageable, limit 5); spleen: 6.9 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / eccrine glands: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),91,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / eccrine glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157456,CCNB2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 47.8014% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.6707% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.6291% (minimum 65%, Baseline (adaptation disabled))",-0.163709,-0.0232932,-0.271986,0,12,partial,73.6,32.2,71.2,"bone marrow: 73.6 nTPM (vital, limit 1); thymus: 71.2 nTPM (manageable, limit 5); lymph node: 32.2 nTPM (protected, limit 3); rectum: 16.3 nTPM (protected, limit 3); esophagus: 15.7 nTPM (protected, limit 3); colon: 13.8 nTPM (protected, limit 3); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 11.7 nTPM (vital, limit 1); skin: 9.2 nTPM (manageable, limit 5); spleen: 6.9 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); lung: 2.1 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / eccrine glands: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),91,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / eccrine glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157456,CCNB2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.8018% (minimum 99%, Missing); choroid plexus: 97.8102% (minimum 99%, Missing); hippocampal formation: 98.8930% (minimum 99%, Missing); hypothalamus: 98.7109% (minimum 99%, Missing); kidney: 97.8995% (minimum 99%, Missing); pituitary gland: 98.1685% (minimum 99%, Missing); retina: 91.0790% (minimum 99%, Missing)",0.0472093,0.00989031,-0.0792099,0,9,partial,10.5,2.2,4.2,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157578,LCA5L,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347209,0.27989,0.16079,0,9,partial,10.5,2.2,4.2,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157578,LCA5L,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347209,0.27989,0.16079,0,9,partial,10.5,2.2,4.2,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157578,LCA5L,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347209,0.27989,0.16079,0,9,partial,10.5,2.2,4.2,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157578,LCA5L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.312298,0.27989,0.16079,0,9,partial,10.5,2.2,4.2,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157578,LCA5L,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9365% (minimum 99%, Missing); amygdala: 98.6637% (minimum 99%, Missing); basal ganglia: 98.8839% (minimum 99%, Missing); bone marrow: 95.8874% (minimum 99%, Missing); choroid plexus: 97.1491% (minimum 99%, Missing); hippocampal formation: 98.6637% (minimum 99%, Missing); hypothalamus: 98.6637% (minimum 99%, Missing); kidney: 97.3626% (minimum 99%, Missing); liver: 96.7249% (minimum 99%, Missing); midbrain: 98.6637% (minimum 99%, Missing); pancreas: 98.2262% (minimum 99%, Missing); pituitary gland: 97.1491% (minimum 99%, Missing); retina: 97.3626% (minimum 99%, Missing); spinal cord: 98.4444% (minimum 99%, Missing)",0.0344444,0.0100885,-0.0311255,0,80,unavailable,1.9,0.9,0.7,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157653,C9orf43,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334444,0.280088,0.208874,0,80,unavailable,1.9,0.9,0.7,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157653,C9orf43,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334444,0.280088,0.208874,0,80,unavailable,1.9,0.9,0.7,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157653,C9orf43,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334444,0.280088,0.208874,0,80,unavailable,1.9,0.9,0.7,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157653,C9orf43,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334444,0.280088,0.208874,0,80,unavailable,1.9,0.9,0.7,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157653,C9orf43,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 99%, Missing); amygdala: 90.0000% (minimum 99%, Missing); basal ganglia: 81.8182% (minimum 99%, Missing); bone marrow: 90.0000% (minimum 99%, Missing); cerebral cortex: 85.7143% (minimum 99%, Missing); choroid plexus: 16.9811% (minimum 99%, Missing); colon: 69.2308% (minimum 97%, Missing); duodenum: 94.7368% (minimum 99%, Missing); esophagus: 94.7368% (minimum 97%, Missing); heart muscle: 90.0000% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 85.7143% (minimum 99%, Missing); kidney: 40.0000% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); midbrain: 94.7368% (minimum 99%, Missing); pancreas: 78.2609% (minimum 99%, Missing); parathyroid gland: 31.0345% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 85.7143% (minimum 97%, Missing); retina: 36.7347% (minimum 99%, Missing); salivary gland: 31.5789% (minimum 97%, Missing); skin: 85.7143% (minimum 95%, Missing); small intestine: 90.0000% (minimum 99%, Missing); spinal cord: 81.8182% (minimum 99%, Missing); spleen: 94.7368% (minimum 95%, Missing); stomach: 94.7368% (minimum 97%, Missing); thymus: 81.8182% (minimum 95%, Missing); thyroid gland: 72.0000% (minimum 95%, Missing); urinary bladder: 81.8182% (minimum 97%, Missing)",-0.23,-0.659655,-0.820189,0,80,unavailable,8.8,4,0.7,"choroid plexus: 8.8 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157703,SVOPL,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 75%, Missing); choroid plexus: 16.9811% (minimum 75%, Missing); colon: 69.2308% (minimum 70%, Missing); kidney: 40.0000% (minimum 75%, Missing); parathyroid gland: 31.0345% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 36.7347% (minimum 75%, Missing); salivary gland: 31.5789% (minimum 70%, Missing)",0.07,-0.389655,-0.580189,0,80,unavailable,8.8,4,0.7,"choroid plexus: 8.8 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157703,SVOPL,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 75%, Missing); choroid plexus: 16.9811% (minimum 75%, Missing); colon: 69.2308% (minimum 70%, Missing); kidney: 40.0000% (minimum 75%, Missing); parathyroid gland: 31.0345% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 36.7347% (minimum 75%, Missing); salivary gland: 31.5789% (minimum 70%, Missing)",0.07,-0.389655,-0.580189,0,80,unavailable,8.8,4,0.7,"choroid plexus: 8.8 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157703,SVOPL,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 75%, Missing); choroid plexus: 16.9811% (minimum 75%, Missing); colon: 69.2308% (minimum 70%, Missing); kidney: 40.0000% (minimum 75%, Missing); parathyroid gland: 31.0345% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 36.7347% (minimum 75%, Missing); salivary gland: 31.5789% (minimum 70%, Missing)",0.07,-0.389655,-0.580189,0,80,unavailable,8.8,4,0.7,"choroid plexus: 8.8 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157703,SVOPL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 16.9811% (minimum 75%, Baseline (adaptation disabled)); colon: 69.2308% (minimum 70%, Baseline (adaptation disabled)); kidney: 40.0000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 31.0345% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 36.7347% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 31.5789% (minimum 70%, Baseline (adaptation disabled))",0.07,-0.389655,-0.580189,0,80,unavailable,8.8,4,0.7,"choroid plexus: 8.8 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157703,SVOPL,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 96.0000% (minimum 99%, Missing); choroid plexus: 94.9153% (minimum 99%, Missing); lung: 98.8235% (minimum 99%, Missing); thyroid gland: 87.5000% (minimum 95%, Missing)",-0.075,0.0182353,-0.0408475,0,80,unavailable,0.9,0.2,2.4,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157884,CIB4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.288235,0.199153,0,80,unavailable,0.9,0.2,2.4,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157884,CIB4,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.288235,0.199153,0,80,unavailable,0.9,0.2,2.4,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157884,CIB4,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.288235,0.199153,0,80,unavailable,0.9,0.2,2.4,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157884,CIB4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.288235,0.199153,0,80,unavailable,0.9,0.2,2.4,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000157884,CIB4,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8701% (minimum 99%, Missing); bone marrow: 75.4310% (minimum 99%, Missing); cerebral cortex: 98.8701% (minimum 99%, Missing); choroid plexus: 98.3146% (minimum 99%, Missing); colon: 84.1346% (minimum 97%, Missing); duodenum: 85.7843% (minimum 99%, Missing); esophagus: 92.5926% (minimum 97%, Missing); liver: 97.2222% (minimum 98%, Approved); lung: 98.3146% (minimum 99%, Missing); lymph node: 84.9515% (minimum 97%, Missing); pancreas: 98.3146% (minimum 99%, Missing); rectum: 81.7757% (minimum 97%, Missing); skin: 93.0851% (minimum 95%, Missing); small intestine: 85.7843% (minimum 99%, Missing); smooth muscle: 96.1538% (minimum 98%, Approved); stomach: 94.0860% (minimum 97%, Missing); thymus: 67.0498% (minimum 95%, Missing)",-0.279502,-0.152243,-0.23569,0,8,partial,5.7,3.9,8.6,"thymus: 8.6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158402,CDC25C,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0204981,0.117757,0.00431034,0,8,partial,5.7,3.9,8.6,"thymus: 8.6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158402,CDC25C,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0204981,0.117757,0.00431034,0,8,partial,5.7,3.9,8.6,"thymus: 8.6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158402,CDC25C,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0204981,0.117757,0.00431034,0,8,partial,5.7,3.9,8.6,"thymus: 8.6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158402,CDC25C,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0204981,0.117757,0.00431034,0,8,partial,5.7,3.9,8.6,"thymus: 8.6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158402,CDC25C,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.9524% (minimum 99%, Missing); amygdala: 93.8575% (minimum 99%, Missing); basal ganglia: 90.9524% (minimum 99%, Missing); bone marrow: 98.4536% (minimum 99%, Missing); cerebellum: 97.9487% (minimum 99%, Missing); cerebral cortex: 96.9543% (minimum 99%, Missing); choroid plexus: 58.2317% (minimum 99%, Missing); duodenum: 97.6982% (minimum 99%, Missing); heart muscle: 97.2010% (minimum 99%, Missing); hippocampal formation: 92.2705% (minimum 99%, Missing); hypothalamus: 90.5213% (minimum 99%, Missing); kidney: 92.4939% (minimum 99%, Missing); liver: 98.2005% (minimum 99%, Missing); lung: 92.2705% (minimum 99%, Missing); midbrain: 94.0887% (minimum 99%, Missing); pancreas: 95.5000% (minimum 99%, Missing); parathyroid gland: 93.8575% (minimum 97%, Missing); pituitary gland: 85.6502% (minimum 99%, Missing); retina: 77.6423% (minimum 99%, Missing); salivary gland: 95.2618% (minimum 97%, Missing); skeletal muscle: 98.2005% (minimum 99%, Missing); small intestine: 97.9487% (minimum 99%, Missing); smooth muscle: 98.4536% (minimum 99%, Missing); spinal cord: 94.7891% (minimum 99%, Missing); thyroid gland: 91.8269% (minimum 95%, Missing)",-0.0317308,-0.0314251,-0.407683,0,80,unavailable,27.4,2.5,3.4,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158423,RIBC1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 58.2317% (minimum 75%, Missing)",0.268269,0.238575,-0.167683,0,80,unavailable,27.4,2.5,3.4,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158423,RIBC1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 58.2317% (minimum 75%, Missing)",0.268269,0.238575,-0.167683,0,80,unavailable,27.4,2.5,3.4,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158423,RIBC1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 58.2317% (minimum 75%, Missing)",0.268269,0.238575,-0.167683,0,80,unavailable,27.4,2.5,3.4,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158423,RIBC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 58.2317% (minimum 75%, Baseline (adaptation disabled))",0.268269,0.238575,-0.167683,0,80,unavailable,27.4,2.5,3.4,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158423,RIBC1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 81.2500% (minimum 95%, Missing); bone marrow: 59.0909% (minimum 99%, Missing); heart muscle: 92.8571% (minimum 99%, Missing); lymph node: 68.4211% (minimum 97%, Missing); thymus: 36.1111% (minimum 95%, Missing); thyroid gland: 92.8571% (minimum 95%, Missing)",-0.588889,-0.285789,-0.399091,0,80,unavailable,0.9,0.6,2.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158497,HMHB1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 59.0909% (minimum 75%, Missing); lymph node: 68.4211% (minimum 70%, Missing); thymus: 36.1111% (minimum 65%, Missing)",-0.288889,-0.0157895,-0.159091,0,80,unavailable,0.9,0.6,2.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158497,HMHB1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 59.0909% (minimum 75%, Missing); lymph node: 68.4211% (minimum 70%, Missing); thymus: 36.1111% (minimum 65%, Missing)",-0.288889,-0.0157895,-0.159091,0,80,unavailable,0.9,0.6,2.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158497,HMHB1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 59.0909% (minimum 75%, Missing); lymph node: 68.4211% (minimum 70%, Missing); thymus: 36.1111% (minimum 65%, Missing)",-0.288889,-0.0157895,-0.159091,0,80,unavailable,0.9,0.6,2.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158497,HMHB1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 59.0909% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.4211% (minimum 70%, Baseline (adaptation disabled)); thymus: 36.1111% (minimum 65%, Baseline (adaptation disabled))",-0.288889,-0.0157895,-0.159091,0,80,unavailable,0.9,0.6,2.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158497,HMHB1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 98.1982% (minimum 99%, Missing); lymph node: 94.7826% (minimum 97%, Missing); pancreas: 98.4940% (minimum 99%, Missing); pituitary gland: 96.4602% (minimum 99%, Missing); small intestine: 98.1982% (minimum 99%, Missing); thymus: 93.6963% (minimum 95%, Missing)",-0.0130372,-0.0221739,-0.0253982,0,80,unavailable,1.2,1.8,2.2,"pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158525,CPA5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.286963,0.247826,0.214602,0,80,unavailable,1.2,1.8,2.2,"pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158525,CPA5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.286963,0.247826,0.214602,0,80,unavailable,1.2,1.8,2.2,"pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158525,CPA5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.286963,0.247826,0.214602,0,80,unavailable,1.2,1.8,2.2,"pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158525,CPA5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.286963,0.247826,0.214602,0,80,unavailable,1.2,1.8,2.2,"pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158525,CPA5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158553,POM121L2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158553,POM121L2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158553,POM121L2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158553,POM121L2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158553,POM121L2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 96.2687% (minimum 97%, Supported)",0.046139,0.03,-0.00731343,0,2,partial,1,0.3,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158639,PAGE5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346139,0.3,0.246139,0,2,partial,1,0.3,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158639,PAGE5,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346139,0.3,0.246139,0,2,partial,1,0.3,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158639,PAGE5,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346139,0.3,0.246139,0,2,partial,1,0.3,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158639,PAGE5,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346139,0.288506,0.212687,0,2,partial,1,0.3,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158639,PAGE5,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.1538% (minimum 95%, Missing); adrenal gland: 92.3077% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 70.5882% (minimum 99%, Missing); bone marrow: 54.5455% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); cerebral cortex: 80.0000% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 80.0000% (minimum 97%, Missing); heart muscle: 31.5789% (minimum 99%, Missing); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 80.0000% (minimum 99%, Missing); liver: 70.5882% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 80.0000% (minimum 99%, Missing); parathyroid gland: 92.3077% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 41.3793% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 30.7692% (minimum 99%, Missing); skin: 70.5882% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 85.7143% (minimum 95%, Missing); stomach: 75.0000% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing); thyroid gland: 75.0000% (minimum 95%, Missing); tongue: 32.4324% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.488462,-0.645676,-0.682308,0,80,unavailable,2.7,2.5,1.4,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158683,PKD1L1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.1538% (minimum 65%, Missing); basal ganglia: 70.5882% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); heart muscle: 31.5789% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); liver: 70.5882% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); retina: 41.3793% (minimum 75%, Missing); skeletal muscle: 30.7692% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing); tongue: 32.4324% (minimum 70%, Missing)",-0.188462,-0.375676,-0.442308,0,80,unavailable,2.7,2.5,1.4,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158683,PKD1L1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.1538% (minimum 65%, Missing); basal ganglia: 70.5882% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); heart muscle: 31.5789% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); liver: 70.5882% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); retina: 41.3793% (minimum 75%, Missing); skeletal muscle: 30.7692% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing); tongue: 32.4324% (minimum 70%, Missing)",-0.188462,-0.375676,-0.442308,0,80,unavailable,2.7,2.5,1.4,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158683,PKD1L1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.1538% (minimum 65%, Missing); basal ganglia: 70.5882% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); heart muscle: 31.5789% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); liver: 70.5882% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); retina: 41.3793% (minimum 75%, Missing); skeletal muscle: 30.7692% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing); tongue: 32.4324% (minimum 70%, Missing)",-0.188462,-0.375676,-0.442308,0,80,unavailable,2.7,2.5,1.4,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158683,PKD1L1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.1538% (minimum 65%, Baseline (adaptation disabled)); basal ganglia: 70.5882% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 54.5455% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 75.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 31.5789% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 70.5882% (minimum 75%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 41.3793% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 30.7692% (minimum 75%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 32.4324% (minimum 70%, Baseline (adaptation disabled))",-0.188462,-0.375676,-0.442308,0,80,unavailable,2.7,2.5,1.4,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158683,PKD1L1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.4003% (minimum 99%, Missing); amygdala: 90.2394% (minimum 99%, Missing); basal ganglia: 90.0735% (minimum 99%, Missing); bone marrow: 69.9001% (minimum 99%, Missing); cerebellum: 94.2308% (minimum 95%, Enhanced); cerebral cortex: 91.4179% (minimum 99%, Missing); choroid plexus: 79.4165% (minimum 99%, Missing); colon: 49.0000% (minimum 97%, Missing); duodenum: 47.4347% (minimum 99%, Missing); esophagus: 37.0931% (minimum 97%, Missing); heart muscle: 79.8046% (minimum 99%, Missing); hippocampal formation: 89.4161% (minimum 99%, Missing); hypothalamus: 90.4059% (minimum 99%, Missing); kidney: 55.5556% (minimum 99%, Missing); liver: 40.6977% (minimum 99%, Missing); lung: 42.9448% (minimum 99%, Missing); lymph node: 79.1599% (minimum 97%, Missing); midbrain: 88.4477% (minimum 99%, Missing); pancreas: 54.7486% (minimum 99%, Missing); parathyroid gland: 58.2640% (minimum 97%, Missing); pituitary gland: 72.8083% (minimum 99%, Missing); rectum: 49.4450% (minimum 97%, Missing); retina: 95.8904% (minimum 99%, Missing); salivary gland: 50.5676% (minimum 97%, Missing); skeletal muscle: 89.4161% (minimum 95%, Enhanced); skin: 51.1482% (minimum 95%, Missing); small intestine: 44.1441% (minimum 99%, Missing); smooth muscle: 84.9220% (minimum 95%, Enhanced); spinal cord: 88.6076% (minimum 99%, Missing); spleen: 70.0000% (minimum 95%, Missing); stomach: 48.8534% (minimum 97%, Missing); thymus: 75.3846% (minimum 95%, Missing); thyroid gland: 56.2572% (minimum 95%, Missing); tongue: 89.0909% (minimum 97%, Missing); urinary bladder: 49.3454% (minimum 97%, Missing)",-0.438518,-0.599069,-0.583023,0,6,partial,71.4,83.1,46.8,"esophagus: 83.1 nTPM (protected, limit 2); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 2); colon: 51 nTPM (protected, limit 2); urinary bladder: 50.3 nTPM (protected, limit 2); rectum: 50.1 nTPM (protected, limit 2); salivary gland: 47.9 nTPM (protected, limit 2); skin: 46.8 nTPM (manageable, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (manageable, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 2); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); pituitary gland: 18.3 nTPM (vital, limit 1); thymus: 16 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 2); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 6); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 2); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158769,F11R,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.4003% (minimum 75%, Missing); bone marrow: 69.9001% (minimum 75%, Missing); colon: 49.0000% (minimum 70%, Missing); duodenum: 47.4347% (minimum 75%, Missing); esophagus: 37.0931% (minimum 70%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 40.6977% (minimum 75%, Missing); lung: 42.9448% (minimum 75%, Missing); pancreas: 54.7486% (minimum 75%, Missing); parathyroid gland: 58.2640% (minimum 70%, Missing); pituitary gland: 72.8083% (minimum 75%, Missing); rectum: 49.4450% (minimum 70%, Missing); salivary gland: 50.5676% (minimum 70%, Missing); skin: 51.1482% (minimum 65%, Missing); small intestine: 44.1441% (minimum 75%, Missing); stomach: 48.8534% (minimum 70%, Missing); thyroid gland: 56.2572% (minimum 65%, Missing); urinary bladder: 49.3454% (minimum 70%, Missing)",-0.138518,-0.329069,-0.343023,0,6,partial,71.4,83.1,46.8,"esophagus: 83.1 nTPM (protected, limit 2); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 2); colon: 51 nTPM (protected, limit 2); urinary bladder: 50.3 nTPM (protected, limit 2); rectum: 50.1 nTPM (protected, limit 2); salivary gland: 47.9 nTPM (protected, limit 2); skin: 46.8 nTPM (manageable, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (manageable, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 2); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); pituitary gland: 18.3 nTPM (vital, limit 1); thymus: 16 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 2); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 6); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 2); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158769,F11R,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.4003% (minimum 75%, Missing); bone marrow: 69.9001% (minimum 75%, Missing); colon: 49.0000% (minimum 70%, Missing); duodenum: 47.4347% (minimum 75%, Missing); esophagus: 37.0931% (minimum 70%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 40.6977% (minimum 75%, Missing); lung: 42.9448% (minimum 75%, Missing); pancreas: 54.7486% (minimum 75%, Missing); parathyroid gland: 58.2640% (minimum 70%, Missing); pituitary gland: 72.8083% (minimum 75%, Missing); rectum: 49.4450% (minimum 70%, Missing); salivary gland: 50.5676% (minimum 70%, Missing); skin: 51.1482% (minimum 65%, Missing); small intestine: 44.1441% (minimum 75%, Missing); stomach: 48.8534% (minimum 70%, Missing); thyroid gland: 56.2572% (minimum 65%, Missing); urinary bladder: 49.3454% (minimum 70%, Missing)",-0.138518,-0.329069,-0.343023,0,6,partial,71.4,83.1,46.8,"esophagus: 83.1 nTPM (protected, limit 3); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 3); colon: 51 nTPM (protected, limit 3); urinary bladder: 50.3 nTPM (protected, limit 3); rectum: 50.1 nTPM (protected, limit 3); salivary gland: 47.9 nTPM (protected, limit 3); skin: 46.8 nTPM (manageable, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (manageable, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 3); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); pituitary gland: 18.3 nTPM (vital, limit 1); thymus: 16 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 3); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 6); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 3); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158769,F11R,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.4003% (minimum 75%, Missing); bone marrow: 69.9001% (minimum 75%, Missing); colon: 49.0000% (minimum 70%, Missing); duodenum: 47.4347% (minimum 75%, Missing); esophagus: 37.0931% (minimum 70%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 40.6977% (minimum 75%, Missing); lung: 42.9448% (minimum 75%, Missing); pancreas: 54.7486% (minimum 75%, Missing); parathyroid gland: 58.2640% (minimum 70%, Missing); pituitary gland: 72.8083% (minimum 75%, Missing); rectum: 49.4450% (minimum 70%, Missing); salivary gland: 50.5676% (minimum 70%, Missing); skin: 51.1482% (minimum 65%, Missing); small intestine: 44.1441% (minimum 75%, Missing); stomach: 48.8534% (minimum 70%, Missing); thyroid gland: 56.2572% (minimum 65%, Missing); urinary bladder: 49.3454% (minimum 70%, Missing)",-0.138518,-0.329069,-0.343023,0,6,partial,71.4,83.1,46.8,"esophagus: 83.1 nTPM (protected, limit 3); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 3); colon: 51 nTPM (protected, limit 3); urinary bladder: 50.3 nTPM (protected, limit 3); rectum: 50.1 nTPM (protected, limit 3); salivary gland: 47.9 nTPM (protected, limit 3); skin: 46.8 nTPM (manageable, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (manageable, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 3); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); pituitary gland: 18.3 nTPM (vital, limit 1); thymus: 16 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 3); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 6); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 3); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158769,F11R,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.4003% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 69.9001% (minimum 75%, Baseline (adaptation disabled)); colon: 49.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 47.4347% (minimum 75%, Baseline (adaptation disabled)); esophagus: 37.0931% (minimum 70%, Baseline (adaptation disabled)); kidney: 55.5556% (minimum 75%, Baseline (adaptation disabled)); liver: 40.6977% (minimum 75%, Baseline (adaptation disabled)); lung: 42.9448% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.7486% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.2640% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.8083% (minimum 75%, Baseline (adaptation disabled)); rectum: 49.4450% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 50.5676% (minimum 70%, Baseline (adaptation disabled)); skin: 51.1482% (minimum 65%, Baseline (adaptation disabled)); small intestine: 44.1441% (minimum 75%, Baseline (adaptation disabled)); stomach: 48.8534% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 56.2572% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 49.3454% (minimum 70%, Baseline (adaptation disabled))",-0.138518,-0.329069,-0.343023,0,6,partial,71.4,83.1,46.8,"esophagus: 83.1 nTPM (protected, limit 3); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 3); colon: 51 nTPM (protected, limit 3); urinary bladder: 50.3 nTPM (protected, limit 3); rectum: 50.1 nTPM (protected, limit 3); salivary gland: 47.9 nTPM (protected, limit 3); skin: 46.8 nTPM (manageable, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (manageable, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 3); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); adipose tissue: 20.4 nTPM (manageable, limit 5); pituitary gland: 18.3 nTPM (vital, limit 1); thymus: 16 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 3); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 3); skeletal muscle: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158769,F11R,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.6410% (minimum 95%, Missing); adrenal gland: 70.6587% (minimum 99%, Missing); amygdala: 76.6234% (minimum 99%, Missing); basal ganglia: 77.1242% (minimum 99%, Missing); bone marrow: 48.7603% (minimum 99%, Missing); cerebellum: 40.5498% (minimum 99%, Missing); cerebral cortex: 65.5556% (minimum 99%, Missing); choroid plexus: 86.7647% (minimum 99%, Missing); colon: 71.0843% (minimum 97%, Missing); duodenum: 76.1290% (minimum 99%, Missing); esophagus: 75.1592% (minimum 97%, Missing); heart muscle: 79.7297% (minimum 99%, Missing); hippocampal formation: 74.2138% (minimum 99%, Missing); hypothalamus: 71.9512% (minimum 99%, Missing); kidney: 74.6835% (minimum 99%, Missing); liver: 65.1934% (minimum 99%, Missing); lung: 63.7838% (minimum 99%, Missing); lymph node: 36.4198% (minimum 97%, Missing); midbrain: 74.2138% (minimum 99%, Missing); pancreas: 74.2138% (minimum 99%, Missing); parathyroid gland: 64.4809% (minimum 97%, Missing); pituitary gland: 80.8219% (minimum 99%, Missing); rectum: 68.6047% (minimum 97%, Missing); retina: 59.8985% (minimum 99%, Missing); salivary gland: 75.1592% (minimum 97%, Missing); skeletal muscle: 77.6316% (minimum 99%, Missing); skin: 72.3926% (minimum 95%, Missing); small intestine: 74.6835% (minimum 99%, Missing); smooth muscle: 75.1592% (minimum 99%, Missing); spinal cord: 69.8225% (minimum 99%, Missing); spleen: 57.8431% (minimum 95%, Missing); stomach: 71.9512% (minimum 97%, Missing); thymus: 44.6970% (minimum 95%, Missing); thyroid gland: 71.0843% (minimum 95%, Missing); tongue: 78.1457% (minimum 97%, Missing); urinary bladder: 68.6047% (minimum 97%, Missing)",-0.50303,-0.605802,-0.584502,0,2,partial,17.3,20.6,14.6,"lymph node: 20.6 nTPM (protected, limit 2); cerebellum: 17.3 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 2); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158987,RAPGEF6,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.6587% (minimum 75%, Missing); bone marrow: 48.7603% (minimum 75%, Missing); cerebellum: 40.5498% (minimum 75%, Missing); cerebral cortex: 65.5556% (minimum 75%, Missing); hippocampal formation: 74.2138% (minimum 75%, Missing); hypothalamus: 71.9512% (minimum 75%, Missing); kidney: 74.6835% (minimum 75%, Missing); liver: 65.1934% (minimum 75%, Missing); lung: 63.7838% (minimum 75%, Missing); lymph node: 36.4198% (minimum 70%, Missing); midbrain: 74.2138% (minimum 75%, Missing); pancreas: 74.2138% (minimum 75%, Missing); parathyroid gland: 64.4809% (minimum 70%, Missing); rectum: 68.6047% (minimum 70%, Missing); retina: 59.8985% (minimum 75%, Missing); small intestine: 74.6835% (minimum 75%, Missing); spinal cord: 69.8225% (minimum 75%, Missing); spleen: 57.8431% (minimum 65%, Missing); thymus: 44.6970% (minimum 65%, Missing); urinary bladder: 68.6047% (minimum 70%, Missing)",-0.20303,-0.335802,-0.344502,0,2,partial,17.3,20.6,14.6,"lymph node: 20.6 nTPM (protected, limit 2); cerebellum: 17.3 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 2); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158987,RAPGEF6,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.6587% (minimum 75%, Missing); bone marrow: 48.7603% (minimum 75%, Missing); cerebellum: 40.5498% (minimum 75%, Missing); cerebral cortex: 65.5556% (minimum 75%, Missing); hippocampal formation: 74.2138% (minimum 75%, Missing); hypothalamus: 71.9512% (minimum 75%, Missing); kidney: 74.6835% (minimum 75%, Missing); liver: 65.1934% (minimum 75%, Missing); lung: 63.7838% (minimum 75%, Missing); lymph node: 36.4198% (minimum 70%, Missing); midbrain: 74.2138% (minimum 75%, Missing); pancreas: 74.2138% (minimum 75%, Missing); parathyroid gland: 64.4809% (minimum 70%, Missing); rectum: 68.6047% (minimum 70%, Missing); retina: 59.8985% (minimum 75%, Missing); small intestine: 74.6835% (minimum 75%, Missing); spinal cord: 69.8225% (minimum 75%, Missing); spleen: 57.8431% (minimum 65%, Missing); thymus: 44.6970% (minimum 65%, Missing); urinary bladder: 68.6047% (minimum 70%, Missing)",-0.20303,-0.335802,-0.344502,0,2,partial,17.3,20.6,14.6,"lymph node: 20.6 nTPM (protected, limit 3); cerebellum: 17.3 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 3); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158987,RAPGEF6,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.6587% (minimum 75%, Missing); bone marrow: 48.7603% (minimum 75%, Missing); cerebellum: 40.5498% (minimum 75%, Missing); cerebral cortex: 65.5556% (minimum 75%, Missing); hippocampal formation: 74.2138% (minimum 75%, Missing); hypothalamus: 71.9512% (minimum 75%, Missing); kidney: 74.6835% (minimum 75%, Missing); liver: 65.1934% (minimum 75%, Missing); lung: 63.7838% (minimum 75%, Missing); lymph node: 36.4198% (minimum 70%, Missing); midbrain: 74.2138% (minimum 75%, Missing); pancreas: 74.2138% (minimum 75%, Missing); parathyroid gland: 64.4809% (minimum 70%, Missing); rectum: 68.6047% (minimum 70%, Missing); retina: 59.8985% (minimum 75%, Missing); small intestine: 74.6835% (minimum 75%, Missing); spinal cord: 69.8225% (minimum 75%, Missing); spleen: 57.8431% (minimum 65%, Missing); thymus: 44.6970% (minimum 65%, Missing); urinary bladder: 68.6047% (minimum 70%, Missing)",-0.20303,-0.335802,-0.344502,0,2,partial,17.3,20.6,14.6,"lymph node: 20.6 nTPM (protected, limit 3); cerebellum: 17.3 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 3); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158987,RAPGEF6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.6587% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 48.7603% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 40.5498% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.5556% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.2138% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.9512% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.6835% (minimum 75%, Baseline (adaptation disabled)); liver: 65.1934% (minimum 75%, Baseline (adaptation disabled)); lung: 63.7838% (minimum 75%, Baseline (adaptation disabled)); lymph node: 36.4198% (minimum 70%, Baseline (adaptation disabled)); midbrain: 74.2138% (minimum 75%, Baseline (adaptation disabled)); pancreas: 74.2138% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.4809% (minimum 70%, Baseline (adaptation disabled)); rectum: 68.6047% (minimum 70%, Baseline (adaptation disabled)); retina: 59.8985% (minimum 75%, Baseline (adaptation disabled)); small intestine: 74.6835% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.8225% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.8431% (minimum 65%, Baseline (adaptation disabled)); thymus: 44.6970% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 68.6047% (minimum 70%, Baseline (adaptation disabled))",-0.20303,-0.335802,-0.344502,0,2,partial,17.3,20.6,14.6,"lymph node: 20.6 nTPM (protected, limit 3); cerebellum: 17.3 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 3); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000158987,RAPGEF6,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.7711% (minimum 95%, Missing); adrenal gland: 68.1716% (minimum 99%, Missing); amygdala: 63.5789% (minimum 99%, Missing); basal ganglia: 64.5299% (minimum 99%, Missing); bone marrow: 81.2921% (minimum 95%, Enhanced); cerebellum: 55.2608% (minimum 99%, Missing); cerebral cortex: 63.9153% (minimum 99%, Missing); choroid plexus: 47.1507% (minimum 99%, Missing); colon: 70.2326% (minimum 97%, Missing); duodenum: 81.6216% (minimum 99%, Missing); esophagus: 66.9623% (minimum 80%, Enhanced); heart muscle: 69.9884% (minimum 95%, Enhanced); hippocampal formation: 61.5698% (minimum 99%, Missing); hypothalamus: 58.0769% (minimum 99%, Missing); kidney: 62.2039% (minimum 99%, Missing); liver: 68.0947% (minimum 95%, Enhanced); lung: 71.3105% (minimum 99%, Missing); lymph node: 78.9542% (minimum 97%, Missing); midbrain: 66.8882% (minimum 99%, Missing); pancreas: 63.1799% (minimum 99%, Missing); parathyroid gland: 74.6601% (minimum 80%, Enhanced); pituitary gland: 55.9778% (minimum 99%, Missing); rectum: 81.9539% (minimum 97%, Missing); retina: 69.2661% (minimum 99%, Missing); salivary gland: 68.4032% (minimum 97%, Missing); skeletal muscle: 63.9831% (minimum 95%, Enhanced); skin: 69.1867% (minimum 95%, Missing); small intestine: 73.0351% (minimum 99%, Missing); smooth muscle: 84.5938% (minimum 99%, Missing); spinal cord: 68.7144% (minimum 99%, Missing); stomach: 68.0180% (minimum 97%, Missing); thymus: 79.4737% (minimum 95%, Missing); thyroid gland: 65.0161% (minimum 95%, Missing); tongue: 84.2399% (minimum 97%, Missing); urinary bladder: 71.6489% (minimum 97%, Missing)",-0.299839,-0.28982,-0.518493,0,5,partial,67.7,29.8,32.5,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 6); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (manageable, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 12); stomach: 28.4 nTPM (protected, limit 2); liver: 28.3 nTPM (vital, limit 6); adrenal gland: 28.2 nTPM (vital, limit 1); salivary gland: 27.9 nTPM (protected, limit 2); spinal cord: 27.5 nTPM (vital, limit 1); skin: 26.9 nTPM (manageable, limit 5); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 6); colon: 25.6 nTPM (protected, limit 2); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 2); adipose tissue: 22.6 nTPM (manageable, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 12); lymph node: 16.1 nTPM (protected, limit 2); thymus: 15.6 nTPM (manageable, limit 5); bone marrow: 13.9 nTPM (vital, limit 6); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 2); tongue: 11.3 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159079,CFAP298,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.1716% (minimum 75%, Missing); amygdala: 63.5789% (minimum 75%, Missing); basal ganglia: 64.5299% (minimum 75%, Missing); cerebellum: 55.2608% (minimum 75%, Missing); cerebral cortex: 63.9153% (minimum 75%, Missing); choroid plexus: 47.1507% (minimum 75%, Missing); hippocampal formation: 61.5698% (minimum 75%, Missing); hypothalamus: 58.0769% (minimum 75%, Missing); kidney: 62.2039% (minimum 75%, Missing); lung: 71.3105% (minimum 75%, Missing); midbrain: 66.8882% (minimum 75%, Missing); pancreas: 63.1799% (minimum 75%, Missing); pituitary gland: 55.9778% (minimum 75%, Missing); retina: 69.2661% (minimum 75%, Missing); salivary gland: 68.4032% (minimum 70%, Missing); small intestine: 73.0351% (minimum 75%, Missing); spinal cord: 68.7144% (minimum 75%, Missing); stomach: 68.0180% (minimum 70%, Missing)",0.000161464,-0.0198198,-0.278493,0,5,partial,67.7,29.8,32.5,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 6); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (manageable, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 12); stomach: 28.4 nTPM (protected, limit 2); liver: 28.3 nTPM (vital, limit 6); adrenal gland: 28.2 nTPM (vital, limit 1); salivary gland: 27.9 nTPM (protected, limit 2); spinal cord: 27.5 nTPM (vital, limit 1); skin: 26.9 nTPM (manageable, limit 5); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 6); colon: 25.6 nTPM (protected, limit 2); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 2); adipose tissue: 22.6 nTPM (manageable, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 12); lymph node: 16.1 nTPM (protected, limit 2); thymus: 15.6 nTPM (manageable, limit 5); bone marrow: 13.9 nTPM (vital, limit 6); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 2); tongue: 11.3 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159079,CFAP298,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.1716% (minimum 75%, Missing); amygdala: 63.5789% (minimum 75%, Missing); basal ganglia: 64.5299% (minimum 75%, Missing); cerebellum: 55.2608% (minimum 75%, Missing); cerebral cortex: 63.9153% (minimum 75%, Missing); choroid plexus: 47.1507% (minimum 75%, Missing); hippocampal formation: 61.5698% (minimum 75%, Missing); hypothalamus: 58.0769% (minimum 75%, Missing); kidney: 62.2039% (minimum 75%, Missing); lung: 71.3105% (minimum 75%, Missing); midbrain: 66.8882% (minimum 75%, Missing); pancreas: 63.1799% (minimum 75%, Missing); pituitary gland: 55.9778% (minimum 75%, Missing); retina: 69.2661% (minimum 75%, Missing); salivary gland: 68.4032% (minimum 70%, Missing); small intestine: 73.0351% (minimum 75%, Missing); spinal cord: 68.7144% (minimum 75%, Missing); stomach: 68.0180% (minimum 70%, Missing)",0.000161464,-0.0198198,-0.278493,0,5,partial,67.7,29.8,32.5,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 6); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (manageable, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 12); stomach: 28.4 nTPM (protected, limit 3); liver: 28.3 nTPM (vital, limit 6); adrenal gland: 28.2 nTPM (vital, limit 1); salivary gland: 27.9 nTPM (protected, limit 3); spinal cord: 27.5 nTPM (vital, limit 1); skin: 26.9 nTPM (manageable, limit 5); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 6); colon: 25.6 nTPM (protected, limit 3); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 3); adipose tissue: 22.6 nTPM (manageable, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 12); lymph node: 16.1 nTPM (protected, limit 3); thymus: 15.6 nTPM (manageable, limit 5); bone marrow: 13.9 nTPM (vital, limit 6); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 3); tongue: 11.3 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159079,CFAP298,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.1716% (minimum 75%, Missing); amygdala: 63.5789% (minimum 75%, Missing); basal ganglia: 64.5299% (minimum 75%, Missing); cerebellum: 55.2608% (minimum 75%, Missing); cerebral cortex: 63.9153% (minimum 75%, Missing); choroid plexus: 47.1507% (minimum 75%, Missing); hippocampal formation: 61.5698% (minimum 75%, Missing); hypothalamus: 58.0769% (minimum 75%, Missing); kidney: 62.2039% (minimum 75%, Missing); lung: 71.3105% (minimum 75%, Missing); midbrain: 66.8882% (minimum 75%, Missing); pancreas: 63.1799% (minimum 75%, Missing); pituitary gland: 55.9778% (minimum 75%, Missing); retina: 69.2661% (minimum 75%, Missing); salivary gland: 68.4032% (minimum 70%, Missing); small intestine: 73.0351% (minimum 75%, Missing); spinal cord: 68.7144% (minimum 75%, Missing); stomach: 68.0180% (minimum 70%, Missing)",0.000161464,-0.0198198,-0.278493,0,5,partial,67.7,29.8,32.5,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 6); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (manageable, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 12); stomach: 28.4 nTPM (protected, limit 3); liver: 28.3 nTPM (vital, limit 6); adrenal gland: 28.2 nTPM (vital, limit 1); salivary gland: 27.9 nTPM (protected, limit 3); spinal cord: 27.5 nTPM (vital, limit 1); skin: 26.9 nTPM (manageable, limit 5); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 6); colon: 25.6 nTPM (protected, limit 3); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 3); adipose tissue: 22.6 nTPM (manageable, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 12); lymph node: 16.1 nTPM (protected, limit 3); thymus: 15.6 nTPM (manageable, limit 5); bone marrow: 13.9 nTPM (vital, limit 6); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 3); tongue: 11.3 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159079,CFAP298,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.1716% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.5789% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.5299% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.2608% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.9153% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 47.1507% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.9623% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.9884% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.5698% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.0769% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.2039% (minimum 75%, Baseline (adaptation disabled)); liver: 68.0947% (minimum 75%, Baseline (adaptation disabled)); lung: 71.3105% (minimum 75%, Baseline (adaptation disabled)); midbrain: 66.8882% (minimum 75%, Baseline (adaptation disabled)); pancreas: 63.1799% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 55.9778% (minimum 75%, Baseline (adaptation disabled)); retina: 69.2661% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.4032% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 63.9831% (minimum 75%, Baseline (adaptation disabled)); small intestine: 73.0351% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.7144% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.0180% (minimum 70%, Baseline (adaptation disabled))",0.000161464,-0.0303769,-0.278493,0,5,partial,67.7,29.8,32.5,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 1); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (manageable, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 3); stomach: 28.4 nTPM (protected, limit 3); liver: 28.3 nTPM (vital, limit 1); adrenal gland: 28.2 nTPM (vital, limit 1); salivary gland: 27.9 nTPM (protected, limit 3); spinal cord: 27.5 nTPM (vital, limit 1); skin: 26.9 nTPM (manageable, limit 5); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 1); colon: 25.6 nTPM (protected, limit 3); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 3); spleen: 23.1 nTPM (manageable, limit 5); adipose tissue: 22.6 nTPM (manageable, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 3); lymph node: 16.1 nTPM (protected, limit 3); thymus: 15.6 nTPM (manageable, limit 5); bone marrow: 13.9 nTPM (vital, limit 1); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 3); tongue: 11.3 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159079,CFAP298,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.2254% (minimum 60%, Enhanced); adrenal gland: 60.0000% (minimum 99%, Missing); amygdala: 34.7368% (minimum 99%, Missing); basal ganglia: 29.5522% (minimum 99%, Missing); bone marrow: 29.6407% (minimum 99%, Missing); cerebellum: 25.8486% (minimum 99%, Missing); cerebral cortex: 19.3738% (minimum 99%, Missing); choroid plexus: 52.1053% (minimum 99%, Missing); colon: 64.2857% (minimum 97%, Missing); duodenum: 72.2628% (minimum 99%, Missing); esophagus: 69.2308% (minimum 80%, Enhanced); heart muscle: 61.4907% (minimum 95%, Enhanced); hippocampal formation: 28.2051% (minimum 99%, Missing); hypothalamus: 27.8090% (minimum 99%, Missing); kidney: 58.2353% (minimum 99%, Missing); liver: 64.2857% (minimum 95%, Enhanced); lung: 55.9322% (minimum 99%, Missing); lymph node: 61.8750% (minimum 97%, Missing); midbrain: 31.4286% (minimum 99%, Missing); pancreas: 67.8082% (minimum 99%, Missing); parathyroid gland: 55.0000% (minimum 80%, Enhanced); pituitary gland: 42.4893% (minimum 99%, Missing); rectum: 65.1316% (minimum 97%, Missing); retina: 17.4296% (minimum 99%, Missing); salivary gland: 68.2759% (minimum 80%, Enhanced); skeletal muscle: 57.2254% (minimum 99%, Missing); small intestine: 61.8750% (minimum 99%, Missing); smooth muscle: 67.3469% (minimum 99%, Missing); spinal cord: 47.1429% (minimum 99%, Missing); spleen: 56.2500% (minimum 95%, Missing); stomach: 67.3469% (minimum 97%, Missing); thymus: 58.9286% (minimum 95%, Missing); thyroid gland: 58.2353% (minimum 95%, Missing); tongue: 61.4907% (minimum 97%, Missing); urinary bladder: 64.7059% (minimum 97%, Missing)",-0.3875,-0.355093,-0.815704,0,6,partial,46.9,8.1,7.7,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 6); tongue: 6.2 nTPM (protected, limit 2); small intestine: 6.1 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); colon: 5.5 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); rectum: 5.3 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); pancreas: 4.7 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159082,SYNJ1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.0000% (minimum 75%, Missing); amygdala: 34.7368% (minimum 75%, Missing); basal ganglia: 29.5522% (minimum 75%, Missing); bone marrow: 29.6407% (minimum 75%, Missing); cerebellum: 25.8486% (minimum 75%, Missing); cerebral cortex: 19.3738% (minimum 75%, Missing); choroid plexus: 52.1053% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 72.2628% (minimum 75%, Missing); hippocampal formation: 28.2051% (minimum 75%, Missing); hypothalamus: 27.8090% (minimum 75%, Missing); kidney: 58.2353% (minimum 75%, Missing); lung: 55.9322% (minimum 75%, Missing); lymph node: 61.8750% (minimum 70%, Missing); midbrain: 31.4286% (minimum 75%, Missing); pancreas: 67.8082% (minimum 75%, Missing); pituitary gland: 42.4893% (minimum 75%, Missing); rectum: 65.1316% (minimum 70%, Missing); retina: 17.4296% (minimum 75%, Missing); skeletal muscle: 57.2254% (minimum 75%, Missing); small intestine: 61.8750% (minimum 75%, Missing); smooth muscle: 67.3469% (minimum 75%, Missing); spinal cord: 47.1429% (minimum 75%, Missing); spleen: 56.2500% (minimum 65%, Missing); stomach: 67.3469% (minimum 70%, Missing); thymus: 58.9286% (minimum 65%, Missing); thyroid gland: 58.2353% (minimum 65%, Missing); tongue: 61.4907% (minimum 70%, Missing); urinary bladder: 64.7059% (minimum 70%, Missing)",-0.0875,-0.0850932,-0.575704,0,6,partial,46.9,8.1,7.7,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 6); tongue: 6.2 nTPM (protected, limit 2); small intestine: 6.1 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); colon: 5.5 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); rectum: 5.3 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); pancreas: 4.7 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159082,SYNJ1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.0000% (minimum 75%, Missing); amygdala: 34.7368% (minimum 75%, Missing); basal ganglia: 29.5522% (minimum 75%, Missing); bone marrow: 29.6407% (minimum 75%, Missing); cerebellum: 25.8486% (minimum 75%, Missing); cerebral cortex: 19.3738% (minimum 75%, Missing); choroid plexus: 52.1053% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 72.2628% (minimum 75%, Missing); hippocampal formation: 28.2051% (minimum 75%, Missing); hypothalamus: 27.8090% (minimum 75%, Missing); kidney: 58.2353% (minimum 75%, Missing); lung: 55.9322% (minimum 75%, Missing); lymph node: 61.8750% (minimum 70%, Missing); midbrain: 31.4286% (minimum 75%, Missing); pancreas: 67.8082% (minimum 75%, Missing); pituitary gland: 42.4893% (minimum 75%, Missing); rectum: 65.1316% (minimum 70%, Missing); retina: 17.4296% (minimum 75%, Missing); skeletal muscle: 57.2254% (minimum 75%, Missing); small intestine: 61.8750% (minimum 75%, Missing); smooth muscle: 67.3469% (minimum 75%, Missing); spinal cord: 47.1429% (minimum 75%, Missing); spleen: 56.2500% (minimum 65%, Missing); stomach: 67.3469% (minimum 70%, Missing); thymus: 58.9286% (minimum 65%, Missing); thyroid gland: 58.2353% (minimum 65%, Missing); tongue: 61.4907% (minimum 70%, Missing); urinary bladder: 64.7059% (minimum 70%, Missing)",-0.0875,-0.0850932,-0.575704,0,6,partial,46.9,8.1,7.7,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 6); tongue: 6.2 nTPM (protected, limit 3); small intestine: 6.1 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 3); colon: 5.5 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); rectum: 5.3 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); pancreas: 4.7 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159082,SYNJ1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.0000% (minimum 75%, Missing); amygdala: 34.7368% (minimum 75%, Missing); basal ganglia: 29.5522% (minimum 75%, Missing); bone marrow: 29.6407% (minimum 75%, Missing); cerebellum: 25.8486% (minimum 75%, Missing); cerebral cortex: 19.3738% (minimum 75%, Missing); choroid plexus: 52.1053% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 72.2628% (minimum 75%, Missing); hippocampal formation: 28.2051% (minimum 75%, Missing); hypothalamus: 27.8090% (minimum 75%, Missing); kidney: 58.2353% (minimum 75%, Missing); lung: 55.9322% (minimum 75%, Missing); lymph node: 61.8750% (minimum 70%, Missing); midbrain: 31.4286% (minimum 75%, Missing); pancreas: 67.8082% (minimum 75%, Missing); pituitary gland: 42.4893% (minimum 75%, Missing); rectum: 65.1316% (minimum 70%, Missing); retina: 17.4296% (minimum 75%, Missing); skeletal muscle: 57.2254% (minimum 75%, Missing); small intestine: 61.8750% (minimum 75%, Missing); smooth muscle: 67.3469% (minimum 75%, Missing); spinal cord: 47.1429% (minimum 75%, Missing); spleen: 56.2500% (minimum 65%, Missing); stomach: 67.3469% (minimum 70%, Missing); thymus: 58.9286% (minimum 65%, Missing); thyroid gland: 58.2353% (minimum 65%, Missing); tongue: 61.4907% (minimum 70%, Missing); urinary bladder: 64.7059% (minimum 70%, Missing)",-0.0875,-0.0850932,-0.575704,0,6,partial,46.9,8.1,7.7,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 6); tongue: 6.2 nTPM (protected, limit 3); small intestine: 6.1 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 3); colon: 5.5 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); rectum: 5.3 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); pancreas: 4.7 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159082,SYNJ1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.2254% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 34.7368% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 29.5522% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 29.6407% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 25.8486% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 19.3738% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 52.1053% (minimum 75%, Baseline (adaptation disabled)); colon: 64.2857% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.2628% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.2308% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 61.4907% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 28.2051% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 27.8090% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.2353% (minimum 75%, Baseline (adaptation disabled)); liver: 64.2857% (minimum 75%, Baseline (adaptation disabled)); lung: 55.9322% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.8750% (minimum 70%, Baseline (adaptation disabled)); midbrain: 31.4286% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.8082% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.0000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 42.4893% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.1316% (minimum 70%, Baseline (adaptation disabled)); retina: 17.4296% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.2759% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 57.2254% (minimum 75%, Baseline (adaptation disabled)); small intestine: 61.8750% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.3469% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 47.1429% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.2500% (minimum 65%, Baseline (adaptation disabled)); stomach: 67.3469% (minimum 70%, Baseline (adaptation disabled)); thymus: 58.9286% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.2353% (minimum 65%, Baseline (adaptation disabled)); tongue: 61.4907% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 64.7059% (minimum 70%, Baseline (adaptation disabled))",-0.0875,-0.15,-0.575704,0,6,partial,46.9,8.1,7.7,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 3); lung: 7.8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); small intestine: 6.1 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 3); liver: 5.5 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); rectum: 5.3 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 3); esophagus: 4.4 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159082,SYNJ1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0193% (minimum 95%, Missing); adrenal gland: 59.2516% (minimum 99%, Missing); amygdala: 71.4286% (minimum 99%, Missing); basal ganglia: 69.5122% (minimum 99%, Missing); bone marrow: 60.6383% (minimum 99%, Missing); cerebellum: 73.2648% (minimum 99%, Missing); cerebral cortex: 60.6383% (minimum 99%, Missing); choroid plexus: 72.7041% (minimum 99%, Missing); colon: 55.9921% (minimum 97%, Missing); duodenum: 57.0000% (minimum 99%, Missing); esophagus: 54.1825% (minimum 97%, Missing); heart muscle: 58.7629% (minimum 98%, Approved); hippocampal formation: 73.8342% (minimum 99%, Missing); hypothalamus: 71.4286% (minimum 99%, Missing); kidney: 58.5216% (minimum 99%, Missing); liver: 49.8252% (minimum 99%, Missing); lung: 64.7727% (minimum 99%, Missing); lymph node: 49.1379% (minimum 97%, Missing); midbrain: 69.3431% (minimum 99%, Missing); pancreas: 56.7729% (minimum 99%, Missing); parathyroid gland: 59.7484% (minimum 97%, Missing); pituitary gland: 69.6822% (minimum 99%, Missing); rectum: 50.3534% (minimum 97%, Missing); retina: 58.6420% (minimum 99%, Missing); salivary gland: 63.6161% (minimum 97%, Missing); skeletal muscle: 50.4425% (minimum 99%, Missing); skin: 62.9139% (minimum 95%, Missing); small intestine: 60.2537% (minimum 99%, Missing); smooth muscle: 52.9740% (minimum 99%, Missing); spinal cord: 68.1818% (minimum 99%, Missing); spleen: 59.3750% (minimum 95%, Missing); stomach: 59.7484% (minimum 97%, Missing); thymus: 45.9677% (minimum 95%, Missing); thyroid gland: 58.5216% (minimum 95%, Missing); tongue: 57.6923% (minimum 97%, Missing); urinary bladder: 47.8992% (minimum 97%, Missing)",-0.490323,-0.491008,-0.491748,0,1,partial,28.7,31,33.5,"thymus: 33.5 nTPM (manageable, limit 5); urinary bladder: 31 nTPM (protected, limit 2); lymph node: 29.5 nTPM (protected, limit 2); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 2); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 2); adipose tissue: 23.3 nTPM (manageable, limit 5); colon: 22.4 nTPM (protected, limit 2); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 2); thyroid gland: 20.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 2); adrenal gland: 19.6 nTPM (vital, limit 1); spleen: 19.5 nTPM (manageable, limit 5); parathyroid gland: 19.2 nTPM (protected, limit 2); stomach: 19.2 nTPM (protected, limit 2); small intestine: 18.8 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); salivary gland: 16.3 nTPM (protected, limit 2); lung: 15.5 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159131,GART,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0193% (minimum 65%, Missing); adrenal gland: 59.2516% (minimum 75%, Missing); amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 69.5122% (minimum 75%, Missing); bone marrow: 60.6383% (minimum 75%, Missing); cerebellum: 73.2648% (minimum 75%, Missing); cerebral cortex: 60.6383% (minimum 75%, Missing); choroid plexus: 72.7041% (minimum 75%, Missing); colon: 55.9921% (minimum 70%, Missing); duodenum: 57.0000% (minimum 75%, Missing); esophagus: 54.1825% (minimum 70%, Missing); heart muscle: 58.7629% (minimum 70%, Approved); hippocampal formation: 73.8342% (minimum 75%, Missing); hypothalamus: 71.4286% (minimum 75%, Missing); kidney: 58.5216% (minimum 75%, Missing); liver: 49.8252% (minimum 75%, Missing); lung: 64.7727% (minimum 75%, Missing); lymph node: 49.1379% (minimum 70%, Missing); midbrain: 69.3431% (minimum 75%, Missing); pancreas: 56.7729% (minimum 75%, Missing); parathyroid gland: 59.7484% (minimum 70%, Missing); pituitary gland: 69.6822% (minimum 75%, Missing); rectum: 50.3534% (minimum 70%, Missing); retina: 58.6420% (minimum 75%, Missing); salivary gland: 63.6161% (minimum 70%, Missing); skeletal muscle: 50.4425% (minimum 75%, Missing); skin: 62.9139% (minimum 65%, Missing); small intestine: 60.2537% (minimum 75%, Missing); smooth muscle: 52.9740% (minimum 75%, Missing); spinal cord: 68.1818% (minimum 75%, Missing); spleen: 59.3750% (minimum 65%, Missing); stomach: 59.7484% (minimum 70%, Missing); thymus: 45.9677% (minimum 65%, Missing); thyroid gland: 58.5216% (minimum 65%, Missing); tongue: 57.6923% (minimum 70%, Missing); urinary bladder: 47.8992% (minimum 70%, Missing)",-0.190323,-0.221008,-0.251748,0,1,partial,28.7,31,33.5,"thymus: 33.5 nTPM (manageable, limit 5); urinary bladder: 31 nTPM (protected, limit 2); lymph node: 29.5 nTPM (protected, limit 2); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 2); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 2); adipose tissue: 23.3 nTPM (manageable, limit 5); colon: 22.4 nTPM (protected, limit 2); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 2); thyroid gland: 20.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 2); adrenal gland: 19.6 nTPM (vital, limit 1); spleen: 19.5 nTPM (manageable, limit 5); parathyroid gland: 19.2 nTPM (protected, limit 2); stomach: 19.2 nTPM (protected, limit 2); small intestine: 18.8 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); salivary gland: 16.3 nTPM (protected, limit 2); lung: 15.5 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159131,GART,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0193% (minimum 65%, Missing); adrenal gland: 59.2516% (minimum 75%, Missing); amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 69.5122% (minimum 75%, Missing); bone marrow: 60.6383% (minimum 75%, Missing); cerebellum: 73.2648% (minimum 75%, Missing); cerebral cortex: 60.6383% (minimum 75%, Missing); choroid plexus: 72.7041% (minimum 75%, Missing); colon: 55.9921% (minimum 70%, Missing); duodenum: 57.0000% (minimum 75%, Missing); esophagus: 54.1825% (minimum 70%, Missing); heart muscle: 58.7629% (minimum 70%, Approved); hippocampal formation: 73.8342% (minimum 75%, Missing); hypothalamus: 71.4286% (minimum 75%, Missing); kidney: 58.5216% (minimum 75%, Missing); liver: 49.8252% (minimum 75%, Missing); lung: 64.7727% (minimum 75%, Missing); lymph node: 49.1379% (minimum 70%, Missing); midbrain: 69.3431% (minimum 75%, Missing); pancreas: 56.7729% (minimum 75%, Missing); parathyroid gland: 59.7484% (minimum 70%, Missing); pituitary gland: 69.6822% (minimum 75%, Missing); rectum: 50.3534% (minimum 70%, Missing); retina: 58.6420% (minimum 75%, Missing); salivary gland: 63.6161% (minimum 70%, Missing); skeletal muscle: 50.4425% (minimum 75%, Missing); skin: 62.9139% (minimum 65%, Missing); small intestine: 60.2537% (minimum 75%, Missing); smooth muscle: 52.9740% (minimum 75%, Missing); spinal cord: 68.1818% (minimum 75%, Missing); spleen: 59.3750% (minimum 65%, Missing); stomach: 59.7484% (minimum 70%, Missing); thymus: 45.9677% (minimum 65%, Missing); thyroid gland: 58.5216% (minimum 65%, Missing); tongue: 57.6923% (minimum 70%, Missing); urinary bladder: 47.8992% (minimum 70%, Missing)",-0.190323,-0.221008,-0.251748,0,1,partial,28.7,31,33.5,"thymus: 33.5 nTPM (manageable, limit 5); urinary bladder: 31 nTPM (protected, limit 3); lymph node: 29.5 nTPM (protected, limit 3); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 3); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 3); adipose tissue: 23.3 nTPM (manageable, limit 5); colon: 22.4 nTPM (protected, limit 3); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 3); thyroid gland: 20.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 2); adrenal gland: 19.6 nTPM (vital, limit 1); spleen: 19.5 nTPM (manageable, limit 5); parathyroid gland: 19.2 nTPM (protected, limit 3); stomach: 19.2 nTPM (protected, limit 3); small intestine: 18.8 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); salivary gland: 16.3 nTPM (protected, limit 3); lung: 15.5 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159131,GART,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0193% (minimum 65%, Missing); adrenal gland: 59.2516% (minimum 75%, Missing); amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 69.5122% (minimum 75%, Missing); bone marrow: 60.6383% (minimum 75%, Missing); cerebellum: 73.2648% (minimum 75%, Missing); cerebral cortex: 60.6383% (minimum 75%, Missing); choroid plexus: 72.7041% (minimum 75%, Missing); colon: 55.9921% (minimum 70%, Missing); duodenum: 57.0000% (minimum 75%, Missing); esophagus: 54.1825% (minimum 70%, Missing); heart muscle: 58.7629% (minimum 70%, Approved); hippocampal formation: 73.8342% (minimum 75%, Missing); hypothalamus: 71.4286% (minimum 75%, Missing); kidney: 58.5216% (minimum 75%, Missing); liver: 49.8252% (minimum 75%, Missing); lung: 64.7727% (minimum 75%, Missing); lymph node: 49.1379% (minimum 70%, Missing); midbrain: 69.3431% (minimum 75%, Missing); pancreas: 56.7729% (minimum 75%, Missing); parathyroid gland: 59.7484% (minimum 70%, Missing); pituitary gland: 69.6822% (minimum 75%, Missing); rectum: 50.3534% (minimum 70%, Missing); retina: 58.6420% (minimum 75%, Missing); salivary gland: 63.6161% (minimum 70%, Missing); skeletal muscle: 50.4425% (minimum 75%, Missing); skin: 62.9139% (minimum 65%, Missing); small intestine: 60.2537% (minimum 75%, Missing); smooth muscle: 52.9740% (minimum 75%, Missing); spinal cord: 68.1818% (minimum 75%, Missing); spleen: 59.3750% (minimum 65%, Missing); stomach: 59.7484% (minimum 70%, Missing); thymus: 45.9677% (minimum 65%, Missing); thyroid gland: 58.5216% (minimum 65%, Missing); tongue: 57.6923% (minimum 70%, Missing); urinary bladder: 47.8992% (minimum 70%, Missing)",-0.190323,-0.221008,-0.251748,0,1,partial,28.7,31,33.5,"thymus: 33.5 nTPM (manageable, limit 5); urinary bladder: 31 nTPM (protected, limit 3); lymph node: 29.5 nTPM (protected, limit 3); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 3); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 3); adipose tissue: 23.3 nTPM (manageable, limit 5); colon: 22.4 nTPM (protected, limit 3); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 3); thyroid gland: 20.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 2); adrenal gland: 19.6 nTPM (vital, limit 1); spleen: 19.5 nTPM (manageable, limit 5); parathyroid gland: 19.2 nTPM (protected, limit 3); stomach: 19.2 nTPM (protected, limit 3); small intestine: 18.8 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); salivary gland: 16.3 nTPM (protected, limit 3); lung: 15.5 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159131,GART,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0193% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 59.2516% (minimum 75%, Baseline (adaptation disabled)); amygdala: 71.4286% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 69.5122% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 60.6383% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.2648% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.6383% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.7041% (minimum 75%, Baseline (adaptation disabled)); colon: 55.9921% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.1825% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.7629% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.8342% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.4286% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.5216% (minimum 75%, Baseline (adaptation disabled)); liver: 49.8252% (minimum 75%, Baseline (adaptation disabled)); lung: 64.7727% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.1379% (minimum 70%, Baseline (adaptation disabled)); midbrain: 69.3431% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.7729% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.7484% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.6822% (minimum 75%, Baseline (adaptation disabled)); rectum: 50.3534% (minimum 70%, Baseline (adaptation disabled)); retina: 58.6420% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.6161% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 50.4425% (minimum 75%, Baseline (adaptation disabled)); skin: 62.9139% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.2537% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 52.9740% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.1818% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.3750% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.7484% (minimum 70%, Baseline (adaptation disabled)); thymus: 45.9677% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.5216% (minimum 65%, Baseline (adaptation disabled)); tongue: 57.6923% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 47.8992% (minimum 70%, Baseline (adaptation disabled))",-0.190323,-0.221008,-0.251748,0,1,partial,28.7,31,33.5,"thymus: 33.5 nTPM (manageable, limit 5); urinary bladder: 31 nTPM (protected, limit 3); lymph node: 29.5 nTPM (protected, limit 3); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 3); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 3); adipose tissue: 23.3 nTPM (manageable, limit 5); colon: 22.4 nTPM (protected, limit 3); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 3); thyroid gland: 20.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); adrenal gland: 19.6 nTPM (vital, limit 1); spleen: 19.5 nTPM (manageable, limit 5); parathyroid gland: 19.2 nTPM (protected, limit 3); stomach: 19.2 nTPM (protected, limit 3); small intestine: 18.8 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); salivary gland: 16.3 nTPM (protected, limit 3); lung: 15.5 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159131,GART,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 81.5385% (minimum 99%, Missing); lymph node: 94.6429% (minimum 97%, Missing)",0.05,-0.0235714,-0.174615,0,4,partial,1.2,0.3,0,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159217,IGF2BP1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.246429,0.0653846,0,4,partial,1.2,0.3,0,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159217,IGF2BP1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.246429,0.0653846,0,4,partial,1.2,0.3,0,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159217,IGF2BP1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.246429,0.0653846,0,4,partial,1.2,0.3,0,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159217,IGF2BP1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.246429,0.0653846,0,4,partial,1.2,0.3,0,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159217,IGF2BP1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 83.3333% (minimum 95%, Enhanced); colon: 62.5000% (minimum 97%, Missing); duodenum: 0.1982% (minimum 99%, Missing); small intestine: 0.5453% (minimum 99%, Missing); stomach: 29.4118% (minimum 80%, Enhanced); thymus: 83.3333% (minimum 95%, Missing)",-0.116667,-0.505882,-0.988018,0,10,partial,251.8,1.2,0.1,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),74,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159224,GIP,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 62.5000% (minimum 70%, Missing); duodenum: 0.1982% (minimum 75%, Missing); small intestine: 0.5453% (minimum 75%, Missing); stomach: 29.4118% (minimum 55%, Enhanced)",0.183333,-0.255882,-0.748018,0,10,partial,251.8,1.2,0.1,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),74,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159224,GIP,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 62.5000% (minimum 70%, Missing); duodenum: 0.1982% (minimum 75%, Missing); small intestine: 0.5453% (minimum 75%, Missing); stomach: 29.4118% (minimum 55%, Enhanced)",0.183333,-0.255882,-0.748018,0,10,partial,251.8,1.2,0.1,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),74,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159224,GIP,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 62.5000% (minimum 70%, Missing); duodenum: 0.1982% (minimum 75%, Missing); small intestine: 0.5453% (minimum 75%, Missing); stomach: 29.4118% (minimum 55%, Enhanced)",0.183333,-0.255882,-0.748018,0,10,partial,251.8,1.2,0.1,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),74,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159224,GIP,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 62.5000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 0.1982% (minimum 75%, Baseline (adaptation disabled)); small intestine: 0.5453% (minimum 75%, Baseline (adaptation disabled)); stomach: 29.4118% (minimum 70%, Baseline (adaptation disabled))",0.183333,-0.405882,-0.748018,0,10,partial,251.8,1.2,0.1,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),74,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159224,GIP,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 86.9822% (minimum 97%, Supported); retina: 98.6577% (minimum 99%, Missing)",0.05,0.03,-0.100178,0,1,partial,2.2,0,0.1,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159289,GOLGA6A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.219822,0,1,partial,2.2,0,0.1,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159289,GOLGA6A,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.219822,0,1,partial,2.2,0,0.1,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159289,GOLGA6A,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.219822,0,1,partial,2.2,0,0.1,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159289,GOLGA6A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343243,0.3,0.119822,0,1,partial,2.2,0,0.1,"liver: 2.2 nTPM (vital, limit 1)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159289,GOLGA6A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9231% (minimum 99%, Missing); amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 96.9231% (minimum 99%, Missing); bone marrow: 72.4138% (minimum 99%, Missing); cerebellum: 98.4375% (minimum 99%, Missing); cerebral cortex: 91.3043% (minimum 99%, Missing); choroid plexus: 91.3043% (minimum 99%, Missing); duodenum: 98.4375% (minimum 99%, Missing); hippocampal formation: 95.4545% (minimum 99%, Missing); hypothalamus: 91.3043% (minimum 99%, Missing); kidney: 86.3014% (minimum 99%, Missing); lung: 96.9231% (minimum 99%, Missing); midbrain: 96.9231% (minimum 99%, Missing); pancreas: 98.4375% (minimum 99%, Missing); parathyroid gland: 88.7324% (minimum 97%, Missing); pituitary gland: 78.7500% (minimum 99%, Missing); retina: 92.6471% (minimum 99%, Missing); salivary gland: 87.5000% (minimum 97%, Missing); spinal cord: 96.9231% (minimum 99%, Missing); stomach: 95.4545% (minimum 97%, Missing); thyroid gland: 84.0000% (minimum 95%, Missing); urinary bladder: 96.9231% (minimum 97%, Missing)",-0.11,-0.095,-0.265862,0,80,unavailable,2.4,0.9,1.2,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159374,M1AP,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.4138% (minimum 75%, Missing)",0.19,0.175,-0.0258621,0,80,unavailable,2.4,0.9,1.2,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159374,M1AP,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.4138% (minimum 75%, Missing)",0.19,0.175,-0.0258621,0,80,unavailable,2.4,0.9,1.2,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159374,M1AP,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.4138% (minimum 75%, Missing)",0.19,0.175,-0.0258621,0,80,unavailable,2.4,0.9,1.2,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159374,M1AP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.4138% (minimum 75%, Baseline (adaptation disabled))",0.19,0.175,-0.0258621,0,80,unavailable,2.4,0.9,1.2,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159374,M1AP,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 66.6667% (minimum 97%, Missing); skeletal muscle: 72.7273% (minimum 99%, Missing)",0.05,-0.303333,-0.262727,0,80,unavailable,0.3,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159495,TGM7,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 66.6667% (minimum 70%, Missing); skeletal muscle: 72.7273% (minimum 75%, Missing)",0.35,-0.0333333,-0.0227273,0,80,unavailable,0.3,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159495,TGM7,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 66.6667% (minimum 70%, Missing); skeletal muscle: 72.7273% (minimum 75%, Missing)",0.35,-0.0333333,-0.0227273,0,80,unavailable,0.3,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159495,TGM7,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 66.6667% (minimum 70%, Missing); skeletal muscle: 72.7273% (minimum 75%, Missing)",0.35,-0.0333333,-0.0227273,0,80,unavailable,0.3,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159495,TGM7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 72.7273% (minimum 75%, Baseline (adaptation disabled))",0.35,-0.0333333,-0.0227273,0,80,unavailable,0.3,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159495,TGM7,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.5983% (minimum 99%, Missing); basal ganglia: 95.1064% (minimum 99%, Missing); bone marrow: 97.8118% (minimum 99%, Missing); cerebral cortex: 98.8938% (minimum 99%, Missing); choroid plexus: 78.8360% (minimum 99%, Missing); hippocampal formation: 96.1290% (minimum 99%, Missing); hypothalamus: 95.5128% (minimum 99%, Missing); kidney: 98.2418% (minimum 99%, Missing); lung: 95.9227% (minimum 99%, Missing); midbrain: 98.6755% (minimum 99%, Missing); pancreas: 97.5983% (minimum 99%, Missing); pituitary gland: 97.8118% (minimum 99%, Missing); spinal cord: 98.8938% (minimum 99%, Missing)",0.0455457,0.0145815,-0.20164,0,80,unavailable,12,0.7,0.2,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159625,DRC7,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345546,0.284581,0.0383598,0,80,unavailable,12,0.7,0.2,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159625,DRC7,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345546,0.284581,0.0383598,0,80,unavailable,12,0.7,0.2,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159625,DRC7,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345546,0.284581,0.0383598,0,80,unavailable,12,0.7,0.2,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159625,DRC7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345546,0.284581,0.0383598,0,80,unavailable,12,0.7,0.2,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159625,DRC7,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lung: 87.7238% (minimum 95%, Enhanced)",0.05,0.03,-0.0727621,0,3,partial,4.8,0.5,0.1,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159708,LRRC36,admission_only,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
True,compatible,,True,True,True,,0.35,0.3,0.241329,0,3,partial,4.8,0.5,0.1,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159708,LRRC36,selectivity_revised,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
True,compatible,,True,True,True,,0.35,0.3,0.241329,0,3,partial,4.8,0.5,0.1,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159708,LRRC36,grid_revised,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
True,compatible,,True,True,True,,0.35,0.3,0.241329,0,3,partial,4.8,0.5,0.1,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159708,LRRC36,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347093,0.285632,0.127238,0,3,partial,4.8,0.5,0.1,"lung: 4.8 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159708,LRRC36,current_fixed,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.4783% (minimum 95%, Enhanced); amygdala: 94.1606% (minimum 99%, Missing); basal ganglia: 90.8451% (minimum 99%, Missing); cerebellum: 79.4661% (minimum 95%, Enhanced); cerebral cortex: 94.3902% (minimum 95%, Enhanced); choroid plexus: 88.7615% (minimum 99%, Missing); heart muscle: 92.5837% (minimum 95%, Enhanced); hippocampal formation: 94.3902% (minimum 99%, Missing); hypothalamus: 93.7046% (minimum 99%, Missing); kidney: 90.2098% (minimum 95%, Enhanced); liver: 94.8529% (minimum 95%, Enhanced); midbrain: 92.3628% (minimum 99%, Missing); pancreas: 94.3902% (minimum 95%, Enhanced); pituitary gland: 94.3902% (minimum 99%, Missing); retina: 98.4733% (minimum 99%, Missing); skeletal muscle: 89.5833% (minimum 95%, Enhanced); spinal cord: 93.4783% (minimum 99%, Missing); tongue: 93.7046% (minimum 97%, Missing)",0.00555556,-0.032954,-0.155339,0,4,partial,10,4,3.4,"cerebellum: 10 nTPM (vital, limit 6); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159761,C16orf86,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305556,0.237046,0.137615,0,4,partial,10,4,3.4,"cerebellum: 10 nTPM (vital, limit 6); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159761,C16orf86,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305556,0.237046,0.137615,0,4,partial,10,4,3.4,"cerebellum: 10 nTPM (vital, limit 6); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159761,C16orf86,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305556,0.237046,0.137615,0,4,partial,10,4,3.4,"cerebellum: 10 nTPM (vital, limit 6); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159761,C16orf86,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.26924,0.206323,0.0446612,0,4,partial,10,4,3.4,"cerebellum: 10 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); basal ganglia: 3.9 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 3); heart muscle: 3.1 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159761,C16orf86,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.1509% (minimum 95%, Missing); adrenal gland: 61.8182% (minimum 99%, Missing); amygdala: 73.9130% (minimum 99%, Missing); basal ganglia: 70.8333% (minimum 99%, Missing); bone marrow: 51.5152% (minimum 99%, Missing); cerebellum: 48.5714% (minimum 99%, Missing); cerebral cortex: 70.8333% (minimum 99%, Missing); choroid plexus: 61.8182% (minimum 99%, Missing); colon: 64.1509% (minimum 97%, Missing); duodenum: 73.9130% (minimum 99%, Missing); esophagus: 70.8333% (minimum 97%, Missing); heart muscle: 65.3846% (minimum 99%, Missing); hippocampal formation: 73.9130% (minimum 99%, Missing); hypothalamus: 72.3404% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 62.9630% (minimum 99%, Missing); lung: 59.6491% (minimum 99%, Missing); lymph node: 50.7463% (minimum 97%, Missing); midbrain: 73.9130% (minimum 99%, Missing); pancreas: 70.8333% (minimum 99%, Missing); parathyroid gland: 56.6667% (minimum 97%, Missing); pituitary gland: 56.6667% (minimum 99%, Missing); rectum: 64.1509% (minimum 97%, Missing); retina: 43.0380% (minimum 99%, Missing); salivary gland: 65.3846% (minimum 97%, Missing); skeletal muscle: 80.9524% (minimum 99%, Missing); skin: 54.8387% (minimum 95%, Missing); small intestine: 59.6491% (minimum 99%, Missing); smooth muscle: 65.3846% (minimum 99%, Missing); spinal cord: 70.8333% (minimum 99%, Missing); spleen: 47.2222% (minimum 95%, Missing); stomach: 65.3846% (minimum 97%, Missing); thymus: 46.5753% (minimum 95%, Missing); thyroid gland: 53.9683% (minimum 95%, Missing); tongue: 65.3846% (minimum 97%, Missing); urinary bladder: 62.9630% (minimum 97%, Missing)",-0.484247,-0.462537,-0.55962,0,80,unavailable,4.5,3.3,3.9,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); lymph node: 3.3 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159882,ZNF230,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.1509% (minimum 65%, Missing); adrenal gland: 61.8182% (minimum 75%, Missing); amygdala: 73.9130% (minimum 75%, Missing); basal ganglia: 70.8333% (minimum 75%, Missing); bone marrow: 51.5152% (minimum 75%, Missing); cerebellum: 48.5714% (minimum 75%, Missing); cerebral cortex: 70.8333% (minimum 75%, Missing); choroid plexus: 61.8182% (minimum 75%, Missing); colon: 64.1509% (minimum 70%, Missing); duodenum: 73.9130% (minimum 75%, Missing); heart muscle: 65.3846% (minimum 75%, Missing); hippocampal formation: 73.9130% (minimum 75%, Missing); hypothalamus: 72.3404% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 62.9630% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); lymph node: 50.7463% (minimum 70%, Missing); midbrain: 73.9130% (minimum 75%, Missing); pancreas: 70.8333% (minimum 75%, Missing); parathyroid gland: 56.6667% (minimum 70%, Missing); pituitary gland: 56.6667% (minimum 75%, Missing); rectum: 64.1509% (minimum 70%, Missing); retina: 43.0380% (minimum 75%, Missing); salivary gland: 65.3846% (minimum 70%, Missing); skin: 54.8387% (minimum 65%, Missing); small intestine: 59.6491% (minimum 75%, Missing); smooth muscle: 65.3846% (minimum 75%, Missing); spinal cord: 70.8333% (minimum 75%, Missing); spleen: 47.2222% (minimum 65%, Missing); stomach: 65.3846% (minimum 70%, Missing); thymus: 46.5753% (minimum 65%, Missing); thyroid gland: 53.9683% (minimum 65%, Missing); tongue: 65.3846% (minimum 70%, Missing); urinary bladder: 62.9630% (minimum 70%, Missing)",-0.184247,-0.192537,-0.31962,0,80,unavailable,4.5,3.3,3.9,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); lymph node: 3.3 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159882,ZNF230,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.1509% (minimum 65%, Missing); adrenal gland: 61.8182% (minimum 75%, Missing); amygdala: 73.9130% (minimum 75%, Missing); basal ganglia: 70.8333% (minimum 75%, Missing); bone marrow: 51.5152% (minimum 75%, Missing); cerebellum: 48.5714% (minimum 75%, Missing); cerebral cortex: 70.8333% (minimum 75%, Missing); choroid plexus: 61.8182% (minimum 75%, Missing); colon: 64.1509% (minimum 70%, Missing); duodenum: 73.9130% (minimum 75%, Missing); heart muscle: 65.3846% (minimum 75%, Missing); hippocampal formation: 73.9130% (minimum 75%, Missing); hypothalamus: 72.3404% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 62.9630% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); lymph node: 50.7463% (minimum 70%, Missing); midbrain: 73.9130% (minimum 75%, Missing); pancreas: 70.8333% (minimum 75%, Missing); parathyroid gland: 56.6667% (minimum 70%, Missing); pituitary gland: 56.6667% (minimum 75%, Missing); rectum: 64.1509% (minimum 70%, Missing); retina: 43.0380% (minimum 75%, Missing); salivary gland: 65.3846% (minimum 70%, Missing); skin: 54.8387% (minimum 65%, Missing); small intestine: 59.6491% (minimum 75%, Missing); smooth muscle: 65.3846% (minimum 75%, Missing); spinal cord: 70.8333% (minimum 75%, Missing); spleen: 47.2222% (minimum 65%, Missing); stomach: 65.3846% (minimum 70%, Missing); thymus: 46.5753% (minimum 65%, Missing); thyroid gland: 53.9683% (minimum 65%, Missing); tongue: 65.3846% (minimum 70%, Missing); urinary bladder: 62.9630% (minimum 70%, Missing)",-0.184247,-0.192537,-0.31962,0,80,unavailable,4.5,3.3,3.9,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); lymph node: 3.3 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159882,ZNF230,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.1509% (minimum 65%, Missing); adrenal gland: 61.8182% (minimum 75%, Missing); amygdala: 73.9130% (minimum 75%, Missing); basal ganglia: 70.8333% (minimum 75%, Missing); bone marrow: 51.5152% (minimum 75%, Missing); cerebellum: 48.5714% (minimum 75%, Missing); cerebral cortex: 70.8333% (minimum 75%, Missing); choroid plexus: 61.8182% (minimum 75%, Missing); colon: 64.1509% (minimum 70%, Missing); duodenum: 73.9130% (minimum 75%, Missing); heart muscle: 65.3846% (minimum 75%, Missing); hippocampal formation: 73.9130% (minimum 75%, Missing); hypothalamus: 72.3404% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 62.9630% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); lymph node: 50.7463% (minimum 70%, Missing); midbrain: 73.9130% (minimum 75%, Missing); pancreas: 70.8333% (minimum 75%, Missing); parathyroid gland: 56.6667% (minimum 70%, Missing); pituitary gland: 56.6667% (minimum 75%, Missing); rectum: 64.1509% (minimum 70%, Missing); retina: 43.0380% (minimum 75%, Missing); salivary gland: 65.3846% (minimum 70%, Missing); skin: 54.8387% (minimum 65%, Missing); small intestine: 59.6491% (minimum 75%, Missing); smooth muscle: 65.3846% (minimum 75%, Missing); spinal cord: 70.8333% (minimum 75%, Missing); spleen: 47.2222% (minimum 65%, Missing); stomach: 65.3846% (minimum 70%, Missing); thymus: 46.5753% (minimum 65%, Missing); thyroid gland: 53.9683% (minimum 65%, Missing); tongue: 65.3846% (minimum 70%, Missing); urinary bladder: 62.9630% (minimum 70%, Missing)",-0.184247,-0.192537,-0.31962,0,80,unavailable,4.5,3.3,3.9,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); lymph node: 3.3 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159882,ZNF230,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.1509% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 61.8182% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.9130% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.8333% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 51.5152% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.5714% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.8333% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 61.8182% (minimum 75%, Baseline (adaptation disabled)); colon: 64.1509% (minimum 70%, Baseline (adaptation disabled)); duodenum: 73.9130% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 65.3846% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.9130% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.3404% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 62.9630% (minimum 75%, Baseline (adaptation disabled)); lung: 59.6491% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.7463% (minimum 70%, Baseline (adaptation disabled)); midbrain: 73.9130% (minimum 75%, Baseline (adaptation disabled)); pancreas: 70.8333% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 56.6667% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 56.6667% (minimum 75%, Baseline (adaptation disabled)); rectum: 64.1509% (minimum 70%, Baseline (adaptation disabled)); retina: 43.0380% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.3846% (minimum 70%, Baseline (adaptation disabled)); skin: 54.8387% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.6491% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.3846% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.8333% (minimum 75%, Baseline (adaptation disabled)); spleen: 47.2222% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.3846% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.5753% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.9683% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.3846% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.9630% (minimum 70%, Baseline (adaptation disabled))",-0.184247,-0.192537,-0.31962,0,80,unavailable,4.5,3.3,3.9,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); lymph node: 3.3 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159882,ZNF230,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 65.2174% (minimum 95%, Missing); adrenal gland: 57.6923% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 75.0000% (minimum 99%, Missing); cerebellum: 37.5000% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); choroid plexus: 68.1818% (minimum 99%, Missing); colon: 68.1818% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 65.2174% (minimum 97%, Missing); heart muscle: 55.5556% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 68.1818% (minimum 99%, Missing); kidney: 60.0000% (minimum 99%, Missing); liver: 57.6923% (minimum 99%, Missing); lung: 62.5000% (minimum 99%, Missing); lymph node: 71.4286% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 68.1818% (minimum 99%, Missing); parathyroid gland: 40.5405% (minimum 97%, Missing); pituitary gland: 62.5000% (minimum 99%, Missing); rectum: 65.2174% (minimum 97%, Missing); retina: 34.0909% (minimum 99%, Missing); salivary gland: 68.1818% (minimum 97%, Missing); skeletal muscle: 83.3333% (minimum 99%, Missing); skin: 57.6923% (minimum 95%, Missing); small intestine: 68.1818% (minimum 99%, Missing); smooth muscle: 53.5714% (minimum 99%, Missing); spinal cord: 65.2174% (minimum 99%, Missing); spleen: 60.0000% (minimum 95%, Missing); stomach: 65.2174% (minimum 97%, Missing); thymus: 57.6923% (minimum 95%, Missing); thyroid gland: 46.8750% (minimum 95%, Missing); tongue: 68.1818% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",-0.48125,-0.564595,-0.649091,0,80,unavailable,2.9,2.2,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159905,ZNF221,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.6923% (minimum 75%, Missing); cerebellum: 37.5000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 68.1818% (minimum 70%, Missing); esophagus: 65.2174% (minimum 70%, Missing); heart muscle: 55.5556% (minimum 75%, Missing); hypothalamus: 68.1818% (minimum 75%, Missing); kidney: 60.0000% (minimum 75%, Missing); liver: 57.6923% (minimum 75%, Missing); lung: 62.5000% (minimum 75%, Missing); pancreas: 68.1818% (minimum 75%, Missing); parathyroid gland: 40.5405% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 65.2174% (minimum 70%, Missing); retina: 34.0909% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skin: 57.6923% (minimum 65%, Missing); small intestine: 68.1818% (minimum 75%, Missing); smooth muscle: 53.5714% (minimum 75%, Missing); spinal cord: 65.2174% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 65.2174% (minimum 70%, Missing); thymus: 57.6923% (minimum 65%, Missing); thyroid gland: 46.8750% (minimum 65%, Missing); tongue: 68.1818% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.18125,-0.294595,-0.409091,0,80,unavailable,2.9,2.2,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159905,ZNF221,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.6923% (minimum 75%, Missing); cerebellum: 37.5000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 68.1818% (minimum 70%, Missing); esophagus: 65.2174% (minimum 70%, Missing); heart muscle: 55.5556% (minimum 75%, Missing); hypothalamus: 68.1818% (minimum 75%, Missing); kidney: 60.0000% (minimum 75%, Missing); liver: 57.6923% (minimum 75%, Missing); lung: 62.5000% (minimum 75%, Missing); pancreas: 68.1818% (minimum 75%, Missing); parathyroid gland: 40.5405% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 65.2174% (minimum 70%, Missing); retina: 34.0909% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skin: 57.6923% (minimum 65%, Missing); small intestine: 68.1818% (minimum 75%, Missing); smooth muscle: 53.5714% (minimum 75%, Missing); spinal cord: 65.2174% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 65.2174% (minimum 70%, Missing); thymus: 57.6923% (minimum 65%, Missing); thyroid gland: 46.8750% (minimum 65%, Missing); tongue: 68.1818% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.18125,-0.294595,-0.409091,0,80,unavailable,2.9,2.2,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159905,ZNF221,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.6923% (minimum 75%, Missing); cerebellum: 37.5000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 68.1818% (minimum 70%, Missing); esophagus: 65.2174% (minimum 70%, Missing); heart muscle: 55.5556% (minimum 75%, Missing); hypothalamus: 68.1818% (minimum 75%, Missing); kidney: 60.0000% (minimum 75%, Missing); liver: 57.6923% (minimum 75%, Missing); lung: 62.5000% (minimum 75%, Missing); pancreas: 68.1818% (minimum 75%, Missing); parathyroid gland: 40.5405% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 65.2174% (minimum 70%, Missing); retina: 34.0909% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skin: 57.6923% (minimum 65%, Missing); small intestine: 68.1818% (minimum 75%, Missing); smooth muscle: 53.5714% (minimum 75%, Missing); spinal cord: 65.2174% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 65.2174% (minimum 70%, Missing); thymus: 57.6923% (minimum 65%, Missing); thyroid gland: 46.8750% (minimum 65%, Missing); tongue: 68.1818% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.18125,-0.294595,-0.409091,0,80,unavailable,2.9,2.2,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159905,ZNF221,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.6923% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 37.5000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.1818% (minimum 75%, Baseline (adaptation disabled)); colon: 68.1818% (minimum 70%, Baseline (adaptation disabled)); esophagus: 65.2174% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 55.5556% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.1818% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 57.6923% (minimum 75%, Baseline (adaptation disabled)); lung: 62.5000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.1818% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 40.5405% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.5000% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.2174% (minimum 70%, Baseline (adaptation disabled)); retina: 34.0909% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.1818% (minimum 70%, Baseline (adaptation disabled)); skin: 57.6923% (minimum 65%, Baseline (adaptation disabled)); small intestine: 68.1818% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.5714% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.2174% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.2174% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.6923% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 46.8750% (minimum 65%, Baseline (adaptation disabled)); tongue: 68.1818% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 70%, Baseline (adaptation disabled))",-0.18125,-0.294595,-0.409091,0,80,unavailable,2.9,2.2,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159905,ZNF221,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.4211% (minimum 99%, Missing); amygdala: 87.6543% (minimum 99%, Missing); basal ganglia: 86.0606% (minimum 99%, Missing); bone marrow: 89.3082% (minimum 99%, Missing); cerebellum: 77.1739% (minimum 99%, Missing); cerebral cortex: 82.0809% (minimum 99%, Missing); choroid plexus: 90.4459% (minimum 99%, Missing); colon: 83.0409% (minimum 97%, Missing); duodenum: 94.0397% (minimum 99%, Missing); esophagus: 95.9459% (minimum 97%, Missing); heart muscle: 82.5581% (minimum 99%, Missing); hippocampal formation: 86.0606% (minimum 99%, Missing); hypothalamus: 84.0237% (minimum 99%, Missing); kidney: 92.2078% (minimum 99%, Missing); liver: 96.5986% (minimum 99%, Missing); lung: 96.5986% (minimum 99%, Missing); lymph node: 91.6129% (minimum 97%, Missing); midbrain: 89.3082% (minimum 99%, Missing); pancreas: 94.6667% (minimum 99%, Missing); parathyroid gland: 89.3082% (minimum 97%, Missing); pituitary gland: 82.5581% (minimum 99%, Missing); rectum: 92.2078% (minimum 97%, Missing); retina: 75.1323% (minimum 99%, Missing); salivary gland: 94.6667% (minimum 97%, Missing); skeletal muscle: 90.4459% (minimum 99%, Missing); skin: 90.4459% (minimum 95%, Missing); small intestine: 94.0397% (minimum 99%, Missing); smooth muscle: 97.2603% (minimum 99%, Missing); spinal cord: 88.1988% (minimum 99%, Missing); spleen: 91.6129% (minimum 95%, Missing); stomach: 92.8105% (minimum 97%, Missing); thymus: 91.0256% (minimum 95%, Missing); thyroid gland: 88.1988% (minimum 95%, Missing); tongue: 95.9459% (minimum 97%, Missing); urinary bladder: 94.6667% (minimum 97%, Missing)",-0.0680124,-0.139591,-0.238677,0,80,unavailable,4.7,2.9,1.9,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159915,ZNF233,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.231988,0.130409,0.00132275,0,80,unavailable,4.7,2.9,1.9,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159915,ZNF233,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.231988,0.130409,0.00132275,0,80,unavailable,4.7,2.9,1.9,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159915,ZNF233,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.231988,0.130409,0.00132275,0,80,unavailable,4.7,2.9,1.9,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159915,ZNF233,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.231988,0.130409,0.00132275,0,80,unavailable,4.7,2.9,1.9,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000159915,ZNF233,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.8557% (minimum 95%, Missing); adrenal gland: 73.1707% (minimum 99%, Missing); amygdala: 81.0811% (minimum 99%, Missing); basal ganglia: 82.1918% (minimum 99%, Missing); bone marrow: 84.5070% (minimum 99%, Missing); cerebellum: 65.9341% (minimum 99%, Missing); cerebral cortex: 73.1707% (minimum 99%, Missing); choroid plexus: 89.5522% (minimum 99%, Missing); colon: 68.1818% (minimum 97%, Missing); duodenum: 76.9231% (minimum 99%, Missing); esophagus: 64.5161% (minimum 97%, Missing); heart muscle: 72.2892% (minimum 99%, Missing); hippocampal formation: 82.1918% (minimum 99%, Missing); hypothalamus: 84.5070% (minimum 99%, Missing); kidney: 72.2892% (minimum 99%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 68.9655% (minimum 99%, Missing); lymph node: 88.2353% (minimum 97%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 69.7674% (minimum 99%, Missing); parathyroid gland: 63.1579% (minimum 97%, Missing); pituitary gland: 76.9231% (minimum 99%, Missing); rectum: 67.4157% (minimum 97%, Missing); retina: 81.0811% (minimum 99%, Missing); salivary gland: 71.4286% (minimum 97%, Missing); skeletal muscle: 69.7674% (minimum 99%, Missing); skin: 77.9221% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 55.0459% (minimum 99%, Missing); spinal cord: 78.9474% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 65.9341% (minimum 97%, Missing); thymus: 82.1918% (minimum 95%, Missing); thyroid gland: 53.0973% (minimum 95%, Missing); tongue: 50.4202% (minimum 97%, Missing); urinary bladder: 62.5000% (minimum 97%, Missing)",-0.419027,-0.465798,-0.439541,0,2,partial,4.9,5.9,5.3,"tongue: 5.9 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); cerebellum: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160062,ZBTB8A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.8557% (minimum 65%, Missing); adrenal gland: 73.1707% (minimum 75%, Missing); cerebellum: 65.9341% (minimum 75%, Missing); cerebral cortex: 73.1707% (minimum 75%, Missing); colon: 68.1818% (minimum 70%, Missing); esophagus: 64.5161% (minimum 70%, Missing); heart muscle: 72.2892% (minimum 75%, Missing); kidney: 72.2892% (minimum 75%, Missing); lung: 68.9655% (minimum 75%, Missing); pancreas: 69.7674% (minimum 75%, Missing); parathyroid gland: 63.1579% (minimum 70%, Missing); rectum: 67.4157% (minimum 70%, Missing); skeletal muscle: 69.7674% (minimum 75%, Missing); smooth muscle: 55.0459% (minimum 75%, Missing); stomach: 65.9341% (minimum 70%, Missing); thyroid gland: 53.0973% (minimum 65%, Missing); tongue: 50.4202% (minimum 70%, Missing); urinary bladder: 62.5000% (minimum 70%, Missing)",-0.119027,-0.195798,-0.199541,0,2,partial,4.9,5.9,5.3,"tongue: 5.9 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); cerebellum: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160062,ZBTB8A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.8557% (minimum 65%, Missing); adrenal gland: 73.1707% (minimum 75%, Missing); cerebellum: 65.9341% (minimum 75%, Missing); cerebral cortex: 73.1707% (minimum 75%, Missing); colon: 68.1818% (minimum 70%, Missing); esophagus: 64.5161% (minimum 70%, Missing); heart muscle: 72.2892% (minimum 75%, Missing); kidney: 72.2892% (minimum 75%, Missing); lung: 68.9655% (minimum 75%, Missing); pancreas: 69.7674% (minimum 75%, Missing); parathyroid gland: 63.1579% (minimum 70%, Missing); rectum: 67.4157% (minimum 70%, Missing); skeletal muscle: 69.7674% (minimum 75%, Missing); smooth muscle: 55.0459% (minimum 75%, Missing); stomach: 65.9341% (minimum 70%, Missing); thyroid gland: 53.0973% (minimum 65%, Missing); tongue: 50.4202% (minimum 70%, Missing); urinary bladder: 62.5000% (minimum 70%, Missing)",-0.119027,-0.195798,-0.199541,0,2,partial,4.9,5.9,5.3,"tongue: 5.9 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); cerebellum: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); lung: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160062,ZBTB8A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.8557% (minimum 65%, Missing); adrenal gland: 73.1707% (minimum 75%, Missing); cerebellum: 65.9341% (minimum 75%, Missing); cerebral cortex: 73.1707% (minimum 75%, Missing); colon: 68.1818% (minimum 70%, Missing); esophagus: 64.5161% (minimum 70%, Missing); heart muscle: 72.2892% (minimum 75%, Missing); kidney: 72.2892% (minimum 75%, Missing); lung: 68.9655% (minimum 75%, Missing); pancreas: 69.7674% (minimum 75%, Missing); parathyroid gland: 63.1579% (minimum 70%, Missing); rectum: 67.4157% (minimum 70%, Missing); skeletal muscle: 69.7674% (minimum 75%, Missing); smooth muscle: 55.0459% (minimum 75%, Missing); stomach: 65.9341% (minimum 70%, Missing); thyroid gland: 53.0973% (minimum 65%, Missing); tongue: 50.4202% (minimum 70%, Missing); urinary bladder: 62.5000% (minimum 70%, Missing)",-0.119027,-0.195798,-0.199541,0,2,partial,4.9,5.9,5.3,"tongue: 5.9 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); cerebellum: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); lung: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160062,ZBTB8A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.8557% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 73.1707% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.9341% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.1707% (minimum 75%, Baseline (adaptation disabled)); colon: 68.1818% (minimum 70%, Baseline (adaptation disabled)); esophagus: 64.5161% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 72.2892% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.2892% (minimum 75%, Baseline (adaptation disabled)); lung: 68.9655% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.7674% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.1579% (minimum 70%, Baseline (adaptation disabled)); rectum: 67.4157% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 69.7674% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.0459% (minimum 75%, Baseline (adaptation disabled)); stomach: 65.9341% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.0973% (minimum 65%, Baseline (adaptation disabled)); tongue: 50.4202% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.5000% (minimum 70%, Baseline (adaptation disabled))",-0.119027,-0.195798,-0.199541,0,2,partial,4.9,5.9,5.3,"tongue: 5.9 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); cerebellum: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); lung: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160062,ZBTB8A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 88.5246% (minimum 95%, Missing); amygdala: 94.7368% (minimum 99%, Missing); basal ganglia: 94.7368% (minimum 99%, Missing); bone marrow: 84.3750% (minimum 99%, Missing); cerebellum: 98.1818% (minimum 99%, Missing); cerebral cortex: 93.1034% (minimum 99%, Missing); heart muscle: 93.1034% (minimum 99%, Missing); hippocampal formation: 94.7368% (minimum 99%, Missing); hypothalamus: 91.5254% (minimum 99%, Missing); kidney: 96.4286% (minimum 99%, Missing); liver: 96.4286% (minimum 99%, Missing); lung: 93.1034% (minimum 99%, Missing); lymph node: 94.7368% (minimum 97%, Missing); pituitary gland: 94.7368% (minimum 99%, Missing); skeletal muscle: 94.7368% (minimum 99%, Missing); skin: 94.7368% (minimum 95%, Missing); small intestine: 98.1818% (minimum 99%, Missing); smooth muscle: 98.1818% (minimum 99%, Missing); thyroid gland: 85.7143% (minimum 95%, Missing); urinary bladder: 94.7368% (minimum 97%, Missing)",-0.0928571,-0.0226316,-0.14625,0,80,unavailable,1,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160161,CILP2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.207143,0.247368,0.09375,0,80,unavailable,1,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160161,CILP2,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.207143,0.247368,0.09375,0,80,unavailable,1,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160161,CILP2,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.207143,0.247368,0.09375,0,80,unavailable,1,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160161,CILP2,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.207143,0.247368,0.09375,0,80,unavailable,1,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160161,CILP2,current_fixed,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.2963% (minimum 99%, Missing); basal ganglia: 97.0954% (minimum 99%, Missing); cerebral cortex: 90.6977% (minimum 99%, Missing); choroid plexus: 97.9079% (minimum 99%, Missing); hippocampal formation: 96.6942% (minimum 99%, Missing); hypothalamus: 96.2963% (minimum 99%, Missing); midbrain: 95.1220% (minimum 99%, Missing); pituitary gland: 96.6942% (minimum 99%, Missing); retina: 96.2963% (minimum 99%, Missing); spinal cord: 95.1220% (minimum 99%, Missing)",0.0457447,0.0257447,-0.0830233,0,4,partial,2.4,0.7,0.5,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160207,HSF2BP,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.345745,0.295745,0.156977,0,4,partial,2.4,0.7,0.5,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160207,HSF2BP,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.345745,0.295745,0.156977,0,4,partial,2.4,0.7,0.5,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160207,HSF2BP,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.345745,0.295745,0.156977,0,4,partial,2.4,0.7,0.5,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160207,HSF2BP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.329079,0.270954,0.156977,0,4,partial,2.4,0.7,0.5,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160207,HSF2BP,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.1031% (minimum 95%, Missing); adrenal gland: 90.8524% (minimum 99%, Missing); amygdala: 88.8211% (minimum 99%, Missing); basal ganglia: 88.8211% (minimum 99%, Missing); bone marrow: 82.1429% (minimum 99%, Missing); cerebellum: 89.9177% (minimum 99%, Missing); cerebral cortex: 87.5752% (minimum 99%, Missing); choroid plexus: 85.6863% (minimum 99%, Missing); colon: 90.6639% (minimum 97%, Missing); duodenum: 90.8524% (minimum 99%, Missing); esophagus: 94.3844% (minimum 97%, Missing); heart muscle: 93.1770% (minimum 99%, Missing); hippocampal formation: 88.2828% (minimum 99%, Missing); hypothalamus: 88.1048% (minimum 99%, Missing); kidney: 91.2317% (minimum 99%, Missing); liver: 90.4762% (minimum 99%, Missing); lung: 93.3761% (minimum 99%, Missing); lymph node: 95.8333% (minimum 97%, Missing); midbrain: 86.8787% (minimum 99%, Missing); pancreas: 89.5492% (minimum 99%, Missing); pituitary gland: 92.9787% (minimum 99%, Missing); retina: 96.0440% (minimum 99%, Missing); salivary gland: 91.2317% (minimum 97%, Missing); skeletal muscle: 94.7939% (minimum 99%, Missing); small intestine: 91.2317% (minimum 99%, Missing); smooth muscle: 98.6456% (minimum 99%, Missing); spinal cord: 92.0000% (minimum 99%, Missing); spleen: 87.2255% (minimum 95%, Missing); stomach: 93.9785% (minimum 97%, Missing); thyroid gland: 92.7813% (minimum 95%, Missing); tongue: 94.5887% (minimum 97%, Missing); urinary bladder: 90.2893% (minimum 97%, Missing)",-0.0777445,-0.0671074,-0.168571,0,80,unavailable,9.5,4.7,6.4,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.4 nTPM (manageable, limit 5); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); tongue: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160318,CLDND2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.222255,0.202893,0.0714286,0,80,unavailable,9.5,4.7,6.4,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.4 nTPM (manageable, limit 5); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); tongue: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160318,CLDND2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.222255,0.202893,0.0714286,0,80,unavailable,9.5,4.7,6.4,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.4 nTPM (manageable, limit 5); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); liver: 4.6 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160318,CLDND2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.222255,0.202893,0.0714286,0,80,unavailable,9.5,4.7,6.4,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.4 nTPM (manageable, limit 5); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); liver: 4.6 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160318,CLDND2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.222255,0.202893,0.0714286,0,80,unavailable,9.5,4.7,6.4,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.4 nTPM (manageable, limit 5); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); liver: 4.6 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160318,CLDND2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.2131% (minimum 95%, Missing); adrenal gland: 88.1720% (minimum 99%, Missing); amygdala: 78.8462% (minimum 99%, Missing); basal ganglia: 77.3585% (minimum 99%, Missing); bone marrow: 86.3158% (minimum 99%, Missing); cerebellum: 91.1111% (minimum 99%, Missing); cerebral cortex: 74.5455% (minimum 99%, Missing); choroid plexus: 83.6735% (minimum 99%, Missing); colon: 63.5659% (minimum 97%, Missing); duodenum: 86.3158% (minimum 99%, Missing); esophagus: 78.8462% (minimum 97%, Missing); heart muscle: 42.9319% (minimum 99%, Missing); hippocampal formation: 67.2131% (minimum 99%, Missing); hypothalamus: 48.5207% (minimum 99%, Missing); kidney: 65.0794% (minimum 99%, Missing); liver: 93.1818% (minimum 99%, Missing); lung: 86.3158% (minimum 99%, Missing); lymph node: 75.9259% (minimum 97%, Missing); midbrain: 50.6173% (minimum 99%, Missing); pancreas: 79.6117% (minimum 99%, Missing); parathyroid gland: 39.0476% (minimum 97%, Missing); pituitary gland: 54.3046% (minimum 99%, Missing); rectum: 85.4167% (minimum 97%, Missing); retina: 78.0952% (minimum 99%, Missing); salivary gland: 75.9259% (minimum 97%, Missing); skeletal muscle: 90.1099% (minimum 99%, Missing); skin: 68.3333% (minimum 95%, Missing); small intestine: 79.6117% (minimum 99%, Missing); smooth muscle: 58.5714% (minimum 99%, Missing); spinal cord: 65.0794% (minimum 99%, Missing); spleen: 76.6355% (minimum 95%, Missing); stomach: 83.6735% (minimum 97%, Missing); thymus: 94.2529% (minimum 95%, Missing); thyroid gland: 52.2293% (minimum 95%, Missing); tongue: 86.3158% (minimum 97%, Missing); urinary bladder: 72.5664% (minimum 97%, Missing)",-0.427707,-0.579524,-0.560681,0,80,unavailable,10.9,12.8,7.5,"parathyroid gland: 12.8 nTPM (protected, limit 2); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); spinal cord: 4.4 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160321,ZNF208,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 74.5455% (minimum 75%, Missing); colon: 63.5659% (minimum 70%, Missing); heart muscle: 42.9319% (minimum 75%, Missing); hippocampal formation: 67.2131% (minimum 75%, Missing); hypothalamus: 48.5207% (minimum 75%, Missing); kidney: 65.0794% (minimum 75%, Missing); midbrain: 50.6173% (minimum 75%, Missing); parathyroid gland: 39.0476% (minimum 70%, Missing); pituitary gland: 54.3046% (minimum 75%, Missing); smooth muscle: 58.5714% (minimum 75%, Missing); spinal cord: 65.0794% (minimum 75%, Missing); thyroid gland: 52.2293% (minimum 65%, Missing)",-0.127707,-0.309524,-0.320681,0,80,unavailable,10.9,12.8,7.5,"parathyroid gland: 12.8 nTPM (protected, limit 2); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); spinal cord: 4.4 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160321,ZNF208,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 74.5455% (minimum 75%, Missing); colon: 63.5659% (minimum 70%, Missing); heart muscle: 42.9319% (minimum 75%, Missing); hippocampal formation: 67.2131% (minimum 75%, Missing); hypothalamus: 48.5207% (minimum 75%, Missing); kidney: 65.0794% (minimum 75%, Missing); midbrain: 50.6173% (minimum 75%, Missing); parathyroid gland: 39.0476% (minimum 70%, Missing); pituitary gland: 54.3046% (minimum 75%, Missing); smooth muscle: 58.5714% (minimum 75%, Missing); spinal cord: 65.0794% (minimum 75%, Missing); thyroid gland: 52.2293% (minimum 65%, Missing)",-0.127707,-0.309524,-0.320681,0,80,unavailable,10.9,12.8,7.5,"parathyroid gland: 12.8 nTPM (protected, limit 3); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160321,ZNF208,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 74.5455% (minimum 75%, Missing); colon: 63.5659% (minimum 70%, Missing); heart muscle: 42.9319% (minimum 75%, Missing); hippocampal formation: 67.2131% (minimum 75%, Missing); hypothalamus: 48.5207% (minimum 75%, Missing); kidney: 65.0794% (minimum 75%, Missing); midbrain: 50.6173% (minimum 75%, Missing); parathyroid gland: 39.0476% (minimum 70%, Missing); pituitary gland: 54.3046% (minimum 75%, Missing); smooth muscle: 58.5714% (minimum 75%, Missing); spinal cord: 65.0794% (minimum 75%, Missing); thyroid gland: 52.2293% (minimum 65%, Missing)",-0.127707,-0.309524,-0.320681,0,80,unavailable,10.9,12.8,7.5,"parathyroid gland: 12.8 nTPM (protected, limit 3); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160321,ZNF208,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 74.5455% (minimum 75%, Baseline (adaptation disabled)); colon: 63.5659% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 42.9319% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.2131% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 48.5207% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.0794% (minimum 75%, Baseline (adaptation disabled)); midbrain: 50.6173% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 39.0476% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 54.3046% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.5714% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.0794% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 52.2293% (minimum 65%, Baseline (adaptation disabled))",-0.127707,-0.309524,-0.320681,0,80,unavailable,10.9,12.8,7.5,"parathyroid gland: 12.8 nTPM (protected, limit 3); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160321,ZNF208,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.5063% (minimum 95%, Missing); adrenal gland: 76.8817% (minimum 99%, Missing); amygdala: 89.3750% (minimum 99%, Missing); basal ganglia: 82.1839% (minimum 99%, Missing); bone marrow: 67.7725% (minimum 99%, Missing); cerebellum: 69.4175% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 99%, Missing); choroid plexus: 95.3333% (minimum 99%, Missing); colon: 87.1951% (minimum 97%, Missing); duodenum: 85.6287% (minimum 99%, Missing); esophagus: 73.7113% (minimum 97%, Missing); heart muscle: 91.0828% (minimum 99%, Missing); hippocampal formation: 88.8199% (minimum 99%, Missing); hypothalamus: 87.7301% (minimum 99%, Missing); kidney: 89.9371% (minimum 99%, Missing); liver: 95.9732% (minimum 99%, Missing); lung: 87.7301% (minimum 99%, Missing); lymph node: 75.2632% (minimum 97%, Missing); midbrain: 89.3750% (minimum 99%, Missing); pancreas: 79.4444% (minimum 99%, Missing); parathyroid gland: 90.5063% (minimum 97%, Missing); pituitary gland: 92.2581% (minimum 99%, Missing); rectum: 80.3371% (minimum 97%, Missing); retina: 82.1839% (minimum 99%, Missing); salivary gland: 87.7301% (minimum 97%, Missing); skeletal muscle: 84.1176% (minimum 99%, Missing); skin: 69.0821% (minimum 95%, Missing); small intestine: 81.7143% (minimum 99%, Missing); smooth muscle: 89.9371% (minimum 99%, Missing); spinal cord: 88.8199% (minimum 99%, Missing); spleen: 86.1446% (minimum 95%, Missing); stomach: 84.1176% (minimum 97%, Missing); thymus: 72.2222% (minimum 95%, Missing); thyroid gland: 50.7092% (minimum 95%, Missing); tongue: 89.3750% (minimum 97%, Missing); urinary bladder: 89.9371% (minimum 97%, Missing)",-0.442908,-0.232887,-0.312275,0,80,unavailable,6.8,5.1,13.9,"thyroid gland: 13.9 nTPM (manageable, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); skin: 6.4 nTPM (manageable, limit 5); cerebellum: 6.3 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 2); lymph node: 4.7 nTPM (protected, limit 2); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160352,ZNF714,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.7725% (minimum 75%, Missing); cerebellum: 69.4175% (minimum 75%, Missing); thyroid gland: 50.7092% (minimum 65%, Missing)",-0.142908,0.0371134,-0.0722749,0,80,unavailable,6.8,5.1,13.9,"thyroid gland: 13.9 nTPM (manageable, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); skin: 6.4 nTPM (manageable, limit 5); cerebellum: 6.3 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 2); lymph node: 4.7 nTPM (protected, limit 2); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160352,ZNF714,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.7725% (minimum 75%, Missing); cerebellum: 69.4175% (minimum 75%, Missing); thyroid gland: 50.7092% (minimum 65%, Missing)",-0.142908,0.0371134,-0.0722749,0,80,unavailable,6.8,5.1,13.9,"thyroid gland: 13.9 nTPM (manageable, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); skin: 6.4 nTPM (manageable, limit 5); cerebellum: 6.3 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 3); lymph node: 4.7 nTPM (protected, limit 3); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160352,ZNF714,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.7725% (minimum 75%, Missing); cerebellum: 69.4175% (minimum 75%, Missing); thyroid gland: 50.7092% (minimum 65%, Missing)",-0.142908,0.0371134,-0.0722749,0,80,unavailable,6.8,5.1,13.9,"thyroid gland: 13.9 nTPM (manageable, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); skin: 6.4 nTPM (manageable, limit 5); cerebellum: 6.3 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 3); lymph node: 4.7 nTPM (protected, limit 3); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160352,ZNF714,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.7725% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 69.4175% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 50.7092% (minimum 65%, Baseline (adaptation disabled))",-0.142908,0.0371134,-0.0722749,0,80,unavailable,6.8,5.1,13.9,"thyroid gland: 13.9 nTPM (manageable, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); skin: 6.4 nTPM (manageable, limit 5); cerebellum: 6.3 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 3); lymph node: 4.7 nTPM (protected, limit 3); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160352,ZNF714,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 85.8537% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); cerebellum: 90.7216% (minimum 99%, Missing); cerebral cortex: 78.2222% (minimum 99%, Missing); heart muscle: 98.3240% (minimum 99%, Missing); hippocampal formation: 81.1060% (minimum 99%, Missing); hypothalamus: 96.1749% (minimum 99%, Missing); lung: 98.8764% (minimum 99%, Missing); skeletal muscle: 95.6522% (minimum 99%, Missing); spinal cord: 98.8764% (minimum 99%, Missing)",0.038764,0.00237569,-0.323333,0,80,unavailable,8.8,0.5,0.2,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160396,HIPK4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 66.6667% (minimum 75%, Missing)",0.338764,0.272376,-0.0833333,0,80,unavailable,8.8,0.5,0.2,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160396,HIPK4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 66.6667% (minimum 75%, Missing)",0.338764,0.272376,-0.0833333,0,80,unavailable,8.8,0.5,0.2,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160396,HIPK4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 66.6667% (minimum 75%, Missing)",0.338764,0.272376,-0.0833333,0,80,unavailable,8.8,0.5,0.2,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160396,HIPK4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.338764,0.272376,-0.0833333,0,80,unavailable,8.8,0.5,0.2,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160396,HIPK4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.7654% (minimum 99%, Missing); colon: 93.1217% (minimum 97%, Missing); hypothalamus: 98.8764% (minimum 99%, Missing); pituitary gland: 98.9876% (minimum 99%, Missing); rectum: 94.9299% (minimum 97%, Missing)",0.0149123,-0.0387831,-0.00234568,0,80,unavailable,1.1,6.5,3.2,"colon: 6.5 nTPM (protected, limit 2); rectum: 4.7 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160471,COX6B2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.314912,0.231217,0.237654,0,80,unavailable,1.1,6.5,3.2,"colon: 6.5 nTPM (protected, limit 2); rectum: 4.7 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160471,COX6B2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.314912,0.231217,0.237654,0,80,unavailable,1.1,6.5,3.2,"colon: 6.5 nTPM (protected, limit 3); rectum: 4.7 nTPM (protected, limit 3); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160471,COX6B2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.314912,0.231217,0.237654,0,80,unavailable,1.1,6.5,3.2,"colon: 6.5 nTPM (protected, limit 3); rectum: 4.7 nTPM (protected, limit 3); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160471,COX6B2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.314912,0.231217,0.237654,0,80,unavailable,1.1,6.5,3.2,"colon: 6.5 nTPM (protected, limit 3); rectum: 4.7 nTPM (protected, limit 3); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160471,COX6B2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 80.9524% (minimum 97%, Missing); midbrain: 97.1429% (minimum 99%, Missing); spinal cord: 97.1429% (minimum 99%, Missing)",0.0214286,-0.160476,-0.0185714,0,80,unavailable,0.2,1.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160505,NLRP4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321429,0.109524,0.221429,0,80,unavailable,0.2,1.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160505,NLRP4,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321429,0.109524,0.221429,0,80,unavailable,0.2,1.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160505,NLRP4,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321429,0.109524,0.221429,0,80,unavailable,0.2,1.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160505,NLRP4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321429,0.109524,0.221429,0,80,unavailable,0.2,1.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160505,NLRP4,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.0159% (minimum 99%, Missing); amygdala: 96.1089% (minimum 99%, Missing); basal ganglia: 93.2075% (minimum 99%, Missing); choroid plexus: 68.9944% (minimum 99%, Missing); hippocampal formation: 93.5606% (minimum 99%, Missing); hypothalamus: 92.8571% (minimum 99%, Missing); lung: 91.4815% (minimum 99%, Missing); retina: 98.8000% (minimum 99%, Missing); spinal cord: 98.8000% (minimum 99%, Missing)",0.0419679,0.03,-0.300056,0,80,unavailable,11.1,0,0.2,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160838,LRRC71,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.9944% (minimum 75%, Missing)",0.341968,0.3,-0.0600559,0,80,unavailable,11.1,0,0.2,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160838,LRRC71,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.9944% (minimum 75%, Missing)",0.341968,0.3,-0.0600559,0,80,unavailable,11.1,0,0.2,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160838,LRRC71,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.9944% (minimum 75%, Missing)",0.341968,0.3,-0.0600559,0,80,unavailable,11.1,0,0.2,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160838,LRRC71,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.9944% (minimum 75%, Baseline (adaptation disabled))",0.341968,0.3,-0.0600559,0,80,unavailable,11.1,0,0.2,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160838,LRRC71,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 0.1119% (minimum 99%, Missing); amygdala: 97.5610% (minimum 99%, Missing); basal ganglia: 97.5610% (minimum 99%, Missing); cerebellum: 48.7805% (minimum 97%, Supported); cerebral cortex: 95.2381% (minimum 97%, Supported); heart muscle: 90.9091% (minimum 97%, Supported); hippocampal formation: 97.5610% (minimum 99%, Missing); hypothalamus: 97.5610% (minimum 99%, Missing); kidney: 83.3333% (minimum 97%, Supported); liver: 88.8889% (minimum 97%, Supported); lung: 93.0233% (minimum 97%, Supported); midbrain: 97.5610% (minimum 99%, Missing); pancreas: 90.9091% (minimum 97%, Supported); pituitary gland: 90.9091% (minimum 99%, Missing); salivary gland: 75.4717% (minimum 90%, Supported); skeletal muscle: 95.2381% (minimum 97%, Supported); small intestine: 95.2381% (minimum 97%, Supported)",0.05,-0.145283,-0.988881,0,0,routine_complete,3571.8,1.3,0.3,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 3)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160882,CYP11B1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 0.1119% (minimum 75%, Missing); cerebellum: 48.7805% (minimum 65%, Supported)",0.35,0.154717,-0.748881,0,0,routine_complete,3571.8,1.3,0.3,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 3)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160882,CYP11B1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 0.1119% (minimum 75%, Missing); cerebellum: 48.7805% (minimum 65%, Supported)",0.35,0.154717,-0.748881,0,0,routine_complete,3571.8,1.3,0.3,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 3)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160882,CYP11B1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 0.1119% (minimum 75%, Missing); cerebellum: 48.7805% (minimum 65%, Supported)",0.35,0.154717,-0.748881,0,0,routine_complete,3571.8,1.3,0.3,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 3)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160882,CYP11B1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 0.1119% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.7805% (minimum 75%, Baseline (adaptation disabled))",0.280233,0.054717,-0.748881,0,0,routine_complete,3571.8,1.3,0.3,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160882,CYP11B1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 94.8509% (minimum 99%, Missing); basal ganglia: 94.0860% (minimum 99%, Missing); cerebral cortex: 93.0851% (minimum 95%, Enhanced); esophagus: 74.3100% (minimum 80%, Enhanced); hippocampal formation: 94.5946% (minimum 99%, Missing); hypothalamus: 93.8338% (minimum 99%, Missing); kidney: 92.3483% (minimum 95%, Enhanced); midbrain: 93.5829% (minimum 99%, Missing); pituitary gland: 98.8701% (minimum 99%, Missing); retina: 93.8338% (minimum 99%, Missing); skeletal muscle: 87.0647% (minimum 95%, Enhanced); spinal cord: 95.3678% (minimum 99%, Missing); tongue: 96.4187% (minimum 97%, Missing)",0.0331461,-0.0569002,-0.0793532,0,2,partial,5.2,12.1,6.6,"esophagus: 12.1 nTPM (protected, limit 12); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160886,LY6K,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333146,0.1931,0.185829,0,2,partial,5.2,12.1,6.6,"esophagus: 12.1 nTPM (protected, limit 12); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160886,LY6K,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333146,0.1931,0.185829,0,2,partial,5.2,12.1,6.6,"esophagus: 12.1 nTPM (protected, limit 12); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160886,LY6K,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333146,0.1931,0.185829,0,2,partial,5.2,12.1,6.6,"esophagus: 12.1 nTPM (protected, limit 12); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160886,LY6K,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191346,0.0430998,0.120647,0,2,partial,5.2,12.1,6.6,"esophagus: 12.1 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); adipose tissue: 5.2 nTPM (manageable, limit 5); skeletal muscle: 5.2 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160886,LY6K,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.00684211,0,1,partial,0.2,0,0,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160994,TEKTL1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,1,partial,0.2,0,0,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160994,TEKTL1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,1,partial,0.2,0,0,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160994,TEKTL1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,1,partial,0.2,0,0,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160994,TEKTL1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.236842,0,1,partial,0.2,0,0,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000160994,TEKTL1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.2918% (minimum 95%, Enhanced); amygdala: 95.8110% (minimum 99%, Missing); basal ganglia: 95.1974% (minimum 99%, Missing); bone marrow: 94.7592% (minimum 95%, Enhanced); cerebellum: 90.8967% (minimum 95%, Enhanced); choroid plexus: 96.0517% (minimum 99%, Missing); hippocampal formation: 95.5373% (minimum 99%, Missing); hypothalamus: 95.0959% (minimum 99%, Missing); liver: 94.8264% (minimum 95%, Enhanced); lung: 96.4672% (minimum 99%, Missing); midbrain: 96.2936% (minimum 99%, Missing); pituitary gland: 93.9937% (minimum 99%, Missing); retina: 98.7818% (minimum 99%, Missing); small intestine: 94.1590% (minimum 95%, Enhanced); spinal cord: 96.7812% (minimum 99%, Missing)",0.0192141,0.0112981,-0.0500632,0,2,partial,26.8,8.7,23.7,"cerebellum: 26.8 nTPM (vital, limit 6); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 6); adrenal gland: 16.2 nTPM (vital, limit 6); bone marrow: 14.8 nTPM (vital, limit 6); liver: 14.6 nTPM (vital, limit 6); hypothalamus: 13.8 nTPM (vital, limit 1); cerebral cortex: 13.8 nTPM (vital, limit 6); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 6); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); choroid plexus: 11 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 6); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); heart muscle: 9.4 nTPM (vital, limit 6); pancreas: 9 nTPM (vital, limit 6); spinal cord: 8.9 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161036,LRWD1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.319214,0.281298,0.189937,0,2,partial,26.8,8.7,23.7,"cerebellum: 26.8 nTPM (vital, limit 6); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 6); adrenal gland: 16.2 nTPM (vital, limit 6); bone marrow: 14.8 nTPM (vital, limit 6); liver: 14.6 nTPM (vital, limit 6); hypothalamus: 13.8 nTPM (vital, limit 1); cerebral cortex: 13.8 nTPM (vital, limit 6); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 6); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); choroid plexus: 11 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 6); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); heart muscle: 9.4 nTPM (vital, limit 6); pancreas: 9 nTPM (vital, limit 6); spinal cord: 8.9 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161036,LRWD1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.319214,0.281298,0.189937,0,2,partial,26.8,8.7,23.7,"cerebellum: 26.8 nTPM (vital, limit 6); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 6); adrenal gland: 16.2 nTPM (vital, limit 6); bone marrow: 14.8 nTPM (vital, limit 6); liver: 14.6 nTPM (vital, limit 6); hypothalamus: 13.8 nTPM (vital, limit 1); cerebral cortex: 13.8 nTPM (vital, limit 6); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 6); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); choroid plexus: 11 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 6); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); heart muscle: 9.4 nTPM (vital, limit 6); pancreas: 9 nTPM (vital, limit 6); spinal cord: 8.9 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161036,LRWD1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.319214,0.281298,0.189937,0,2,partial,26.8,8.7,23.7,"cerebellum: 26.8 nTPM (vital, limit 6); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 6); adrenal gland: 16.2 nTPM (vital, limit 6); bone marrow: 14.8 nTPM (vital, limit 6); liver: 14.6 nTPM (vital, limit 6); hypothalamus: 13.8 nTPM (vital, limit 1); cerebral cortex: 13.8 nTPM (vital, limit 6); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 6); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); choroid plexus: 11 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 6); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); heart muscle: 9.4 nTPM (vital, limit 6); pancreas: 9 nTPM (vital, limit 6); spinal cord: 8.9 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161036,LRWD1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.268641,0.268512,0.158967,0,2,partial,26.8,8.7,23.7,"cerebellum: 26.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 1); adrenal gland: 16.2 nTPM (vital, limit 1); bone marrow: 14.8 nTPM (vital, limit 1); liver: 14.6 nTPM (vital, limit 1); hypothalamus: 13.8 nTPM (vital, limit 1); cerebral cortex: 13.8 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); choroid plexus: 11 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.4 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 3); colon: 8.6 nTPM (protected, limit 3); urinary bladder: 8.6 nTPM (protected, limit 3); thymus: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 3); adipose tissue: 7.9 nTPM (manageable, limit 5); lymph node: 7.9 nTPM (protected, limit 3); esophagus: 7.5 nTPM (protected, limit 3); salivary gland: 7.3 nTPM (protected, limit 3); skin: 6.4 nTPM (manageable, limit 5); duodenum: 5.2 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 3); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161036,LRWD1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.4762% (minimum 95%, Uncertain); adrenal gland: 71.6981% (minimum 99%, Missing); bone marrow: 84.4444% (minimum 99%, Missing); cerebral cortex: 90.4762% (minimum 99%, Missing); choroid plexus: 73.0769% (minimum 99%, Missing); colon: 95.0000% (minimum 97%, Missing); duodenum: 90.4762% (minimum 99%, Missing); esophagus: 90.4762% (minimum 97%, Missing); heart muscle: 92.6829% (minimum 99%, Missing); kidney: 90.4762% (minimum 99%, Missing); liver: 95.0000% (minimum 99%, Missing); lung: 88.3721% (minimum 99%, Missing); lymph node: 92.6829% (minimum 97%, Missing); pancreas: 90.4762% (minimum 99%, Missing); parathyroid gland: 82.6087% (minimum 97%, Missing); rectum: 95.0000% (minimum 97%, Uncertain); retina: 59.3750% (minimum 99%, Missing); salivary gland: 95.0000% (minimum 97%, Uncertain); skeletal muscle: 97.4359% (minimum 99%, Uncertain); skin: 86.3636% (minimum 95%, Missing); small intestine: 92.6829% (minimum 99%, Missing); smooth muscle: 92.6829% (minimum 99%, Missing); spleen: 88.3721% (minimum 95%, Missing); stomach: 43.6782% (minimum 97%, Missing); thymus: 86.3636% (minimum 95%, Missing); thyroid gland: 82.6087% (minimum 95%, Uncertain); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 92.6829% (minimum 97%, Missing)",-0.123913,-0.533218,-0.39625,0,2,partial,2.6,4.9,0.8,"stomach: 4.9 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161040,FBXL13,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.6981% (minimum 75%, Missing); choroid plexus: 73.0769% (minimum 75%, Missing); retina: 59.3750% (minimum 75%, Missing); stomach: 43.6782% (minimum 70%, Missing)",0.176087,-0.263218,-0.15625,0,2,partial,2.6,4.9,0.8,"stomach: 4.9 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161040,FBXL13,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.6981% (minimum 75%, Missing); choroid plexus: 73.0769% (minimum 75%, Missing); retina: 59.3750% (minimum 75%, Missing); stomach: 43.6782% (minimum 70%, Missing)",0.176087,-0.263218,-0.15625,0,2,partial,2.6,4.9,0.8,"stomach: 4.9 nTPM (protected, limit 3); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161040,FBXL13,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.6981% (minimum 75%, Missing); choroid plexus: 73.0769% (minimum 75%, Missing); retina: 59.3750% (minimum 75%, Missing); stomach: 43.6782% (minimum 70%, Missing)",0.176087,-0.263218,-0.15625,0,2,partial,2.6,4.9,0.8,"stomach: 4.9 nTPM (protected, limit 3); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161040,FBXL13,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.6981% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.0769% (minimum 75%, Baseline (adaptation disabled)); retina: 59.3750% (minimum 75%, Baseline (adaptation disabled)); stomach: 43.6782% (minimum 70%, Baseline (adaptation disabled))",0.176087,-0.263218,-0.15625,0,2,partial,2.6,4.9,0.8,"stomach: 4.9 nTPM (protected, limit 3); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161040,FBXL13,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.9726% (minimum 99%, Missing); basal ganglia: 98.6348% (minimum 99%, Missing); cerebellum: 98.2993% (minimum 99%, Missing); cerebral cortex: 98.6348% (minimum 99%, Missing); colon: 96.6555% (minimum 97%, Missing); heart muscle: 97.9661% (minimum 99%, Missing); hippocampal formation: 98.9726% (minimum 99%, Missing); hypothalamus: 98.9726% (minimum 99%, Missing); kidney: 98.2993% (minimum 99%, Missing); liver: 98.9726% (minimum 99%, Missing); lung: 97.9661% (minimum 99%, Missing); midbrain: 98.9726% (minimum 99%, Missing); pancreas: 98.6348% (minimum 99%, Missing); pituitary gland: 98.6348% (minimum 99%, Missing); skeletal muscle: 98.9726% (minimum 99%, Missing); small intestine: 97.9661% (minimum 99%, Missing); spinal cord: 98.9726% (minimum 99%, Missing)",0.023064,-0.00344482,-0.010339,0,80,unavailable,0.6,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161180,CCDC116,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.323064,0.266555,0.229661,0,80,unavailable,0.6,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161180,CCDC116,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.323064,0.266555,0.229661,0,80,unavailable,0.6,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161180,CCDC116,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.323064,0.266555,0.229661,0,80,unavailable,0.6,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161180,CCDC116,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.323064,0.266555,0.229661,0,80,unavailable,0.6,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161180,CCDC116,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.8426% (minimum 95%, Missing); adrenal gland: 47.9121% (minimum 99%, Missing); amygdala: 62.6437% (minimum 99%, Missing); basal ganglia: 62.6437% (minimum 99%, Missing); bone marrow: 32.6347% (minimum 99%, Missing); cerebellum: 63.0058% (minimum 99%, Missing); cerebral cortex: 58.2888% (minimum 99%, Missing); choroid plexus: 57.8249% (minimum 99%, Missing); colon: 46.7811% (minimum 97%, Missing); duodenum: 27.1144% (minimum 99%, Missing); esophagus: 42.1663% (minimum 97%, Missing); heart muscle: 32.7327% (minimum 99%, Missing); hippocampal formation: 63.5569% (minimum 99%, Missing); hypothalamus: 61.5819% (minimum 99%, Missing); kidney: 55.1899% (minimum 99%, Missing); liver: 52.1531% (minimum 99%, Missing); lung: 50.0000% (minimum 99%, Missing); lymph node: 49.4331% (minimum 97%, Missing); midbrain: 58.7601% (minimum 99%, Missing); pancreas: 57.2178% (minimum 99%, Missing); parathyroid gland: 49.8856% (minimum 97%, Missing); pituitary gland: 63.3721% (minimum 99%, Missing); rectum: 49.5455% (minimum 97%, Missing); retina: 61.0644% (minimum 99%, Missing); salivary gland: 53.8272% (minimum 97%, Missing); skeletal muscle: 23.4409% (minimum 99%, Missing); skin: 34.2767% (minimum 95%, Missing); small intestine: 31.3669% (minimum 99%, Missing); smooth muscle: 49.5455% (minimum 99%, Missing); spinal cord: 58.1333% (minimum 99%, Missing); spleen: 46.2845% (minimum 95%, Missing); stomach: 48.0176% (minimum 97%, Missing); thymus: 55.0505% (minimum 95%, Missing); thyroid gland: 56.7708% (minimum 95%, Missing); tongue: 35.0482% (minimum 97%, Missing); urinary bladder: 51.9048% (minimum 97%, Missing)",-0.607233,-0.619518,-0.755591,0,1,partial,71.2,40.4,41.8,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); skin: 41.8 nTPM (manageable, limit 5); tongue: 40.4 nTPM (protected, limit 2); adipose tissue: 30.3 nTPM (manageable, limit 5); esophagus: 29.9 nTPM (protected, limit 2); spleen: 25.3 nTPM (manageable, limit 5); colon: 24.8 nTPM (protected, limit 2); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 2); lymph node: 22.3 nTPM (protected, limit 2); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 2); parathyroid gland: 21.9 nTPM (protected, limit 2); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 2); liver: 20 nTPM (vital, limit 1); salivary gland: 18.7 nTPM (protected, limit 2); thymus: 17.8 nTPM (manageable, limit 5); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (manageable, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161217,PCYT1A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.8426% (minimum 65%, Missing); adrenal gland: 47.9121% (minimum 75%, Missing); amygdala: 62.6437% (minimum 75%, Missing); basal ganglia: 62.6437% (minimum 75%, Missing); bone marrow: 32.6347% (minimum 75%, Missing); cerebellum: 63.0058% (minimum 75%, Missing); cerebral cortex: 58.2888% (minimum 75%, Missing); choroid plexus: 57.8249% (minimum 75%, Missing); colon: 46.7811% (minimum 70%, Missing); duodenum: 27.1144% (minimum 75%, Missing); esophagus: 42.1663% (minimum 70%, Missing); heart muscle: 32.7327% (minimum 75%, Missing); hippocampal formation: 63.5569% (minimum 75%, Missing); hypothalamus: 61.5819% (minimum 75%, Missing); kidney: 55.1899% (minimum 75%, Missing); liver: 52.1531% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 49.4331% (minimum 70%, Missing); midbrain: 58.7601% (minimum 75%, Missing); pancreas: 57.2178% (minimum 75%, Missing); parathyroid gland: 49.8856% (minimum 70%, Missing); pituitary gland: 63.3721% (minimum 75%, Missing); rectum: 49.5455% (minimum 70%, Missing); retina: 61.0644% (minimum 75%, Missing); salivary gland: 53.8272% (minimum 70%, Missing); skeletal muscle: 23.4409% (minimum 75%, Missing); skin: 34.2767% (minimum 65%, Missing); small intestine: 31.3669% (minimum 75%, Missing); smooth muscle: 49.5455% (minimum 75%, Missing); spinal cord: 58.1333% (minimum 75%, Missing); spleen: 46.2845% (minimum 65%, Missing); stomach: 48.0176% (minimum 70%, Missing); thymus: 55.0505% (minimum 65%, Missing); thyroid gland: 56.7708% (minimum 65%, Missing); tongue: 35.0482% (minimum 70%, Missing); urinary bladder: 51.9048% (minimum 70%, Missing)",-0.307233,-0.349518,-0.515591,0,1,partial,71.2,40.4,41.8,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); skin: 41.8 nTPM (manageable, limit 5); tongue: 40.4 nTPM (protected, limit 2); adipose tissue: 30.3 nTPM (manageable, limit 5); esophagus: 29.9 nTPM (protected, limit 2); spleen: 25.3 nTPM (manageable, limit 5); colon: 24.8 nTPM (protected, limit 2); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 2); lymph node: 22.3 nTPM (protected, limit 2); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 2); parathyroid gland: 21.9 nTPM (protected, limit 2); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 2); liver: 20 nTPM (vital, limit 1); salivary gland: 18.7 nTPM (protected, limit 2); thymus: 17.8 nTPM (manageable, limit 5); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (manageable, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161217,PCYT1A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.8426% (minimum 65%, Missing); adrenal gland: 47.9121% (minimum 75%, Missing); amygdala: 62.6437% (minimum 75%, Missing); basal ganglia: 62.6437% (minimum 75%, Missing); bone marrow: 32.6347% (minimum 75%, Missing); cerebellum: 63.0058% (minimum 75%, Missing); cerebral cortex: 58.2888% (minimum 75%, Missing); choroid plexus: 57.8249% (minimum 75%, Missing); colon: 46.7811% (minimum 70%, Missing); duodenum: 27.1144% (minimum 75%, Missing); esophagus: 42.1663% (minimum 70%, Missing); heart muscle: 32.7327% (minimum 75%, Missing); hippocampal formation: 63.5569% (minimum 75%, Missing); hypothalamus: 61.5819% (minimum 75%, Missing); kidney: 55.1899% (minimum 75%, Missing); liver: 52.1531% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 49.4331% (minimum 70%, Missing); midbrain: 58.7601% (minimum 75%, Missing); pancreas: 57.2178% (minimum 75%, Missing); parathyroid gland: 49.8856% (minimum 70%, Missing); pituitary gland: 63.3721% (minimum 75%, Missing); rectum: 49.5455% (minimum 70%, Missing); retina: 61.0644% (minimum 75%, Missing); salivary gland: 53.8272% (minimum 70%, Missing); skeletal muscle: 23.4409% (minimum 75%, Missing); skin: 34.2767% (minimum 65%, Missing); small intestine: 31.3669% (minimum 75%, Missing); smooth muscle: 49.5455% (minimum 75%, Missing); spinal cord: 58.1333% (minimum 75%, Missing); spleen: 46.2845% (minimum 65%, Missing); stomach: 48.0176% (minimum 70%, Missing); thymus: 55.0505% (minimum 65%, Missing); thyroid gland: 56.7708% (minimum 65%, Missing); tongue: 35.0482% (minimum 70%, Missing); urinary bladder: 51.9048% (minimum 70%, Missing)",-0.307233,-0.349518,-0.515591,0,1,partial,71.2,40.4,41.8,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); skin: 41.8 nTPM (manageable, limit 5); tongue: 40.4 nTPM (protected, limit 3); adipose tissue: 30.3 nTPM (manageable, limit 5); esophagus: 29.9 nTPM (protected, limit 3); spleen: 25.3 nTPM (manageable, limit 5); colon: 24.8 nTPM (protected, limit 3); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 3); lymph node: 22.3 nTPM (protected, limit 3); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 3); parathyroid gland: 21.9 nTPM (protected, limit 3); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 3); liver: 20 nTPM (vital, limit 1); salivary gland: 18.7 nTPM (protected, limit 3); thymus: 17.8 nTPM (manageable, limit 5); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (manageable, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161217,PCYT1A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.8426% (minimum 65%, Missing); adrenal gland: 47.9121% (minimum 75%, Missing); amygdala: 62.6437% (minimum 75%, Missing); basal ganglia: 62.6437% (minimum 75%, Missing); bone marrow: 32.6347% (minimum 75%, Missing); cerebellum: 63.0058% (minimum 75%, Missing); cerebral cortex: 58.2888% (minimum 75%, Missing); choroid plexus: 57.8249% (minimum 75%, Missing); colon: 46.7811% (minimum 70%, Missing); duodenum: 27.1144% (minimum 75%, Missing); esophagus: 42.1663% (minimum 70%, Missing); heart muscle: 32.7327% (minimum 75%, Missing); hippocampal formation: 63.5569% (minimum 75%, Missing); hypothalamus: 61.5819% (minimum 75%, Missing); kidney: 55.1899% (minimum 75%, Missing); liver: 52.1531% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 49.4331% (minimum 70%, Missing); midbrain: 58.7601% (minimum 75%, Missing); pancreas: 57.2178% (minimum 75%, Missing); parathyroid gland: 49.8856% (minimum 70%, Missing); pituitary gland: 63.3721% (minimum 75%, Missing); rectum: 49.5455% (minimum 70%, Missing); retina: 61.0644% (minimum 75%, Missing); salivary gland: 53.8272% (minimum 70%, Missing); skeletal muscle: 23.4409% (minimum 75%, Missing); skin: 34.2767% (minimum 65%, Missing); small intestine: 31.3669% (minimum 75%, Missing); smooth muscle: 49.5455% (minimum 75%, Missing); spinal cord: 58.1333% (minimum 75%, Missing); spleen: 46.2845% (minimum 65%, Missing); stomach: 48.0176% (minimum 70%, Missing); thymus: 55.0505% (minimum 65%, Missing); thyroid gland: 56.7708% (minimum 65%, Missing); tongue: 35.0482% (minimum 70%, Missing); urinary bladder: 51.9048% (minimum 70%, Missing)",-0.307233,-0.349518,-0.515591,0,1,partial,71.2,40.4,41.8,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); skin: 41.8 nTPM (manageable, limit 5); tongue: 40.4 nTPM (protected, limit 3); adipose tissue: 30.3 nTPM (manageable, limit 5); esophagus: 29.9 nTPM (protected, limit 3); spleen: 25.3 nTPM (manageable, limit 5); colon: 24.8 nTPM (protected, limit 3); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 3); lymph node: 22.3 nTPM (protected, limit 3); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 3); parathyroid gland: 21.9 nTPM (protected, limit 3); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 3); liver: 20 nTPM (vital, limit 1); salivary gland: 18.7 nTPM (protected, limit 3); thymus: 17.8 nTPM (manageable, limit 5); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (manageable, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161217,PCYT1A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.8426% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 47.9121% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.6437% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.6437% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 32.6347% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 63.0058% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.2888% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 57.8249% (minimum 75%, Baseline (adaptation disabled)); colon: 46.7811% (minimum 70%, Baseline (adaptation disabled)); duodenum: 27.1144% (minimum 75%, Baseline (adaptation disabled)); esophagus: 42.1663% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 32.7327% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.5569% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.5819% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.1899% (minimum 75%, Baseline (adaptation disabled)); liver: 52.1531% (minimum 75%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.4331% (minimum 70%, Baseline (adaptation disabled)); midbrain: 58.7601% (minimum 75%, Baseline (adaptation disabled)); pancreas: 57.2178% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.8856% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.3721% (minimum 75%, Baseline (adaptation disabled)); rectum: 49.5455% (minimum 70%, Baseline (adaptation disabled)); retina: 61.0644% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.8272% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 23.4409% (minimum 75%, Baseline (adaptation disabled)); skin: 34.2767% (minimum 65%, Baseline (adaptation disabled)); small intestine: 31.3669% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 49.5455% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 58.1333% (minimum 75%, Baseline (adaptation disabled)); spleen: 46.2845% (minimum 65%, Baseline (adaptation disabled)); stomach: 48.0176% (minimum 70%, Baseline (adaptation disabled)); thymus: 55.0505% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.7708% (minimum 65%, Baseline (adaptation disabled)); tongue: 35.0482% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.9048% (minimum 70%, Baseline (adaptation disabled))",-0.307233,-0.349518,-0.515591,0,1,partial,71.2,40.4,41.8,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); skin: 41.8 nTPM (manageable, limit 5); tongue: 40.4 nTPM (protected, limit 3); adipose tissue: 30.3 nTPM (manageable, limit 5); esophagus: 29.9 nTPM (protected, limit 3); spleen: 25.3 nTPM (manageable, limit 5); colon: 24.8 nTPM (protected, limit 3); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 3); lymph node: 22.3 nTPM (protected, limit 3); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 3); parathyroid gland: 21.9 nTPM (protected, limit 3); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 3); liver: 20 nTPM (vital, limit 1); salivary gland: 18.7 nTPM (protected, limit 3); thymus: 17.8 nTPM (manageable, limit 5); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (manageable, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161217,PCYT1A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 72.0000% (minimum 95%, Enhanced); bone marrow: 23.6842% (minimum 99%, Missing); cerebral cortex: 90.0000% (minimum 95%, Enhanced); choroid plexus: 90.0000% (minimum 99%, Missing); colon: 36.0000% (minimum 97%, Missing); duodenum: 34.6154% (minimum 99%, Missing); esophagus: 54.5455% (minimum 80%, Enhanced); heart muscle: 78.2609% (minimum 95%, Enhanced); hippocampal formation: 90.0000% (minimum 99%, Missing); hypothalamus: 94.7368% (minimum 99%, Missing); kidney: 75.0000% (minimum 95%, Enhanced); liver: 48.6486% (minimum 95%, Enhanced); lung: 37.5000% (minimum 99%, Missing); lymph node: 4.8128% (minimum 97%, Missing); midbrain: 94.7368% (minimum 99%, Missing); pancreas: 81.8182% (minimum 95%, Enhanced); pituitary gland: 94.7368% (minimum 99%, Missing); rectum: 37.5000% (minimum 97%, Missing); retina: 85.7143% (minimum 99%, Missing); salivary gland: 46.1538% (minimum 80%, Enhanced); skeletal muscle: 81.8182% (minimum 95%, Enhanced); small intestine: 13.2353% (minimum 99%, Missing); smooth muscle: 69.2308% (minimum 95%, Enhanced); spinal cord: 90.0000% (minimum 99%, Missing); spleen: 7.6271% (minimum 95%, Missing); stomach: 23.0769% (minimum 80%, Enhanced); thymus: 7.4380% (minimum 95%, Missing); tongue: 85.7143% (minimum 97%, Missing); urinary bladder: 29.5082% (minimum 80%, Enhanced)",-0.87562,-0.921872,-0.857647,0,8,partial,11.8,35.6,22.4,"lymph node: 35.6 nTPM (protected, limit 2); thymus: 22.4 nTPM (manageable, limit 5); spleen: 21.8 nTPM (manageable, limit 5); small intestine: 11.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); spleen / cells in white pulp: High (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161405,IKZF3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 23.6842% (minimum 75%, Missing); colon: 36.0000% (minimum 70%, Missing); duodenum: 34.6154% (minimum 75%, Missing); esophagus: 54.5455% (minimum 55%, Enhanced); liver: 48.6486% (minimum 60%, Enhanced); lung: 37.5000% (minimum 75%, Missing); lymph node: 4.8128% (minimum 70%, Missing); rectum: 37.5000% (minimum 70%, Missing); salivary gland: 46.1538% (minimum 55%, Enhanced); small intestine: 13.2353% (minimum 75%, Missing); spleen: 7.6271% (minimum 65%, Missing); stomach: 23.0769% (minimum 55%, Enhanced); thymus: 7.4380% (minimum 65%, Missing); urinary bladder: 29.5082% (minimum 55%, Enhanced)",-0.57562,-0.651872,-0.617647,0,8,partial,11.8,35.6,22.4,"lymph node: 35.6 nTPM (protected, limit 2); thymus: 22.4 nTPM (manageable, limit 5); spleen: 21.8 nTPM (manageable, limit 5); small intestine: 11.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); spleen / cells in white pulp: High (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161405,IKZF3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 23.6842% (minimum 75%, Missing); colon: 36.0000% (minimum 70%, Missing); duodenum: 34.6154% (minimum 75%, Missing); esophagus: 54.5455% (minimum 55%, Enhanced); liver: 48.6486% (minimum 60%, Enhanced); lung: 37.5000% (minimum 75%, Missing); lymph node: 4.8128% (minimum 70%, Missing); rectum: 37.5000% (minimum 70%, Missing); salivary gland: 46.1538% (minimum 55%, Enhanced); small intestine: 13.2353% (minimum 75%, Missing); spleen: 7.6271% (minimum 65%, Missing); stomach: 23.0769% (minimum 55%, Enhanced); thymus: 7.4380% (minimum 65%, Missing); urinary bladder: 29.5082% (minimum 55%, Enhanced)",-0.57562,-0.651872,-0.617647,0,8,partial,11.8,35.6,22.4,"lymph node: 35.6 nTPM (protected, limit 3); thymus: 22.4 nTPM (manageable, limit 5); spleen: 21.8 nTPM (manageable, limit 5); small intestine: 11.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); spleen / cells in white pulp: High (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161405,IKZF3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 23.6842% (minimum 75%, Missing); colon: 36.0000% (minimum 70%, Missing); duodenum: 34.6154% (minimum 75%, Missing); esophagus: 54.5455% (minimum 55%, Enhanced); liver: 48.6486% (minimum 60%, Enhanced); lung: 37.5000% (minimum 75%, Missing); lymph node: 4.8128% (minimum 70%, Missing); rectum: 37.5000% (minimum 70%, Missing); salivary gland: 46.1538% (minimum 55%, Enhanced); small intestine: 13.2353% (minimum 75%, Missing); spleen: 7.6271% (minimum 65%, Missing); stomach: 23.0769% (minimum 55%, Enhanced); thymus: 7.4380% (minimum 65%, Missing); urinary bladder: 29.5082% (minimum 55%, Enhanced)",-0.57562,-0.651872,-0.617647,0,8,partial,11.8,35.6,22.4,"lymph node: 35.6 nTPM (protected, limit 3); thymus: 22.4 nTPM (manageable, limit 5); spleen: 21.8 nTPM (manageable, limit 5); small intestine: 11.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); spleen / cells in white pulp: High (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161405,IKZF3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 72.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 23.6842% (minimum 75%, Baseline (adaptation disabled)); colon: 36.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 34.6154% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.5455% (minimum 70%, Baseline (adaptation disabled)); liver: 48.6486% (minimum 75%, Baseline (adaptation disabled)); lung: 37.5000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 4.8128% (minimum 70%, Baseline (adaptation disabled)); rectum: 37.5000% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 46.1538% (minimum 70%, Baseline (adaptation disabled)); small intestine: 13.2353% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 69.2308% (minimum 75%, Baseline (adaptation disabled)); spleen: 7.6271% (minimum 65%, Baseline (adaptation disabled)); stomach: 23.0769% (minimum 70%, Baseline (adaptation disabled)); thymus: 7.4380% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 29.5082% (minimum 70%, Baseline (adaptation disabled))",-0.57562,-0.651872,-0.617647,0,8,partial,11.8,35.6,22.4,"lymph node: 35.6 nTPM (protected, limit 3); thymus: 22.4 nTPM (manageable, limit 5); spleen: 21.8 nTPM (manageable, limit 5); small intestine: 11.8 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); bone marrow: 5.8 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); spleen / cells in white pulp: High (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161405,IKZF3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.00464286,0,2,partial,0.7,0.8,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161594,KLHL10,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.244643,0,2,partial,0.7,0.8,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161594,KLHL10,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.244643,0,2,partial,0.7,0.8,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161594,KLHL10,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.244643,0,2,partial,0.7,0.8,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161594,KLHL10,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34287,0.285841,0.237589,0,2,partial,0.7,0.8,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161594,KLHL10,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 82.1705% (minimum 99%, Missing); pancreas: 96.5392% (minimum 99%, Missing); retina: 88.0399% (minimum 99%, Missing)",0.05,0.03,-0.168295,0,1,partial,11.5,0,0,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161609,KASH5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.0717054,0,1,partial,11.5,0,0,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161609,KASH5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.0717054,0,1,partial,11.5,0,0,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161609,KASH5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.0717054,0,1,partial,11.5,0,0,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161609,KASH5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.0717054,0,1,partial,11.5,0,0,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161609,KASH5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.0484102,0.03,0.00841017,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161652,IZUMO2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34841,0.3,0.24841,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161652,IZUMO2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34841,0.3,0.24841,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161652,IZUMO2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34841,0.3,0.24841,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161652,IZUMO2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34841,0.3,0.24841,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161652,IZUMO2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8352% (minimum 90%, Approved); adrenal gland: 53.5088% (minimum 99%, Missing); amygdala: 54.8315% (minimum 99%, Missing); basal ganglia: 59.3674% (minimum 99%, Missing); bone marrow: 45.5224% (minimum 99%, Missing); cerebellum: 59.6577% (minimum 99%, Missing); cerebral cortex: 53.8631% (minimum 99%, Missing); choroid plexus: 60.3960% (minimum 99%, Missing); colon: 56.0920% (minimum 97%, Missing); duodenum: 59.3674% (minimum 99%, Missing); esophagus: 47.1954% (minimum 97%, Missing); heart muscle: 52.6998% (minimum 99%, Missing); hippocampal formation: 56.3510% (minimum 99%, Missing); hypothalamus: 52.4731% (minimum 99%, Missing); kidney: 54.7085% (minimum 99%, Missing); liver: 46.1248% (minimum 99%, Missing); lung: 59.9509% (minimum 99%, Missing); lymph node: 54.5861% (minimum 97%, Missing); midbrain: 55.0790% (minimum 99%, Missing); pancreas: 51.2605% (minimum 99%, Missing); parathyroid gland: 53.9823% (minimum 97%, Missing); pituitary gland: 63.8743% (minimum 99%, Missing); rectum: 51.5856% (minimum 97%, Missing); retina: 44.6069% (minimum 99%, Missing); salivary gland: 58.0952% (minimum 97%, Missing); skeletal muscle: 40.5316% (minimum 99%, Missing); skin: 60.0985% (minimum 95%, Missing); small intestine: 59.8039% (minimum 99%, Missing); smooth muscle: 55.4545% (minimum 99%, Missing); spinal cord: 56.7442% (minimum 99%, Missing); spleen: 59.2233% (minimum 95%, Missing); stomach: 55.8352% (minimum 97%, Missing); thymus: 55.7078% (minimum 95%, Missing); thyroid gland: 57.9572% (minimum 95%, Missing); tongue: 51.6949% (minimum 97%, Missing); urinary bladder: 52.5862% (minimum 97%, Missing)",-0.392922,-0.498046,-0.584684,0,2,partial,35.8,27.3,19.4,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 2); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 2); tongue: 22.8 nTPM (protected, limit 2); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 2); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 2); lymph node: 20.3 nTPM (protected, limit 2); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); adipose tissue: 19.3 nTPM (manageable, limit 10); stomach: 19.3 nTPM (protected, limit 2); colon: 19.1 nTPM (protected, limit 2); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (manageable, limit 5); salivary gland: 17.6 nTPM (protected, limit 2); spleen: 16.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 16 nTPM (vital, limit 1); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161654,LSM12,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8352% (minimum 60%, Approved); adrenal gland: 53.5088% (minimum 75%, Missing); amygdala: 54.8315% (minimum 75%, Missing); basal ganglia: 59.3674% (minimum 75%, Missing); bone marrow: 45.5224% (minimum 75%, Missing); cerebellum: 59.6577% (minimum 75%, Missing); cerebral cortex: 53.8631% (minimum 75%, Missing); choroid plexus: 60.3960% (minimum 75%, Missing); colon: 56.0920% (minimum 70%, Missing); duodenum: 59.3674% (minimum 75%, Missing); esophagus: 47.1954% (minimum 70%, Missing); heart muscle: 52.6998% (minimum 75%, Missing); hippocampal formation: 56.3510% (minimum 75%, Missing); hypothalamus: 52.4731% (minimum 75%, Missing); kidney: 54.7085% (minimum 75%, Missing); liver: 46.1248% (minimum 75%, Missing); lung: 59.9509% (minimum 75%, Missing); lymph node: 54.5861% (minimum 70%, Missing); midbrain: 55.0790% (minimum 75%, Missing); pancreas: 51.2605% (minimum 75%, Missing); parathyroid gland: 53.9823% (minimum 70%, Missing); pituitary gland: 63.8743% (minimum 75%, Missing); rectum: 51.5856% (minimum 70%, Missing); retina: 44.6069% (minimum 75%, Missing); salivary gland: 58.0952% (minimum 70%, Missing); skeletal muscle: 40.5316% (minimum 75%, Missing); skin: 60.0985% (minimum 65%, Missing); small intestine: 59.8039% (minimum 75%, Missing); smooth muscle: 55.4545% (minimum 75%, Missing); spinal cord: 56.7442% (minimum 75%, Missing); spleen: 59.2233% (minimum 65%, Missing); stomach: 55.8352% (minimum 70%, Missing); thymus: 55.7078% (minimum 65%, Missing); thyroid gland: 57.9572% (minimum 65%, Missing); tongue: 51.6949% (minimum 70%, Missing); urinary bladder: 52.5862% (minimum 70%, Missing)",-0.0929224,-0.228046,-0.344684,0,2,partial,35.8,27.3,19.4,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 2); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 2); tongue: 22.8 nTPM (protected, limit 2); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 2); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 2); lymph node: 20.3 nTPM (protected, limit 2); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); adipose tissue: 19.3 nTPM (manageable, limit 10); stomach: 19.3 nTPM (protected, limit 2); colon: 19.1 nTPM (protected, limit 2); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (manageable, limit 5); salivary gland: 17.6 nTPM (protected, limit 2); spleen: 16.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 16 nTPM (vital, limit 1); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161654,LSM12,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8352% (minimum 60%, Approved); adrenal gland: 53.5088% (minimum 75%, Missing); amygdala: 54.8315% (minimum 75%, Missing); basal ganglia: 59.3674% (minimum 75%, Missing); bone marrow: 45.5224% (minimum 75%, Missing); cerebellum: 59.6577% (minimum 75%, Missing); cerebral cortex: 53.8631% (minimum 75%, Missing); choroid plexus: 60.3960% (minimum 75%, Missing); colon: 56.0920% (minimum 70%, Missing); duodenum: 59.3674% (minimum 75%, Missing); esophagus: 47.1954% (minimum 70%, Missing); heart muscle: 52.6998% (minimum 75%, Missing); hippocampal formation: 56.3510% (minimum 75%, Missing); hypothalamus: 52.4731% (minimum 75%, Missing); kidney: 54.7085% (minimum 75%, Missing); liver: 46.1248% (minimum 75%, Missing); lung: 59.9509% (minimum 75%, Missing); lymph node: 54.5861% (minimum 70%, Missing); midbrain: 55.0790% (minimum 75%, Missing); pancreas: 51.2605% (minimum 75%, Missing); parathyroid gland: 53.9823% (minimum 70%, Missing); pituitary gland: 63.8743% (minimum 75%, Missing); rectum: 51.5856% (minimum 70%, Missing); retina: 44.6069% (minimum 75%, Missing); salivary gland: 58.0952% (minimum 70%, Missing); skeletal muscle: 40.5316% (minimum 75%, Missing); skin: 60.0985% (minimum 65%, Missing); small intestine: 59.8039% (minimum 75%, Missing); smooth muscle: 55.4545% (minimum 75%, Missing); spinal cord: 56.7442% (minimum 75%, Missing); spleen: 59.2233% (minimum 65%, Missing); stomach: 55.8352% (minimum 70%, Missing); thymus: 55.7078% (minimum 65%, Missing); thyroid gland: 57.9572% (minimum 65%, Missing); tongue: 51.6949% (minimum 70%, Missing); urinary bladder: 52.5862% (minimum 70%, Missing)",-0.0929224,-0.228046,-0.344684,0,2,partial,35.8,27.3,19.4,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 3); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 3); tongue: 22.8 nTPM (protected, limit 3); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 3); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 3); lymph node: 20.3 nTPM (protected, limit 3); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); adipose tissue: 19.3 nTPM (manageable, limit 10); stomach: 19.3 nTPM (protected, limit 3); colon: 19.1 nTPM (protected, limit 3); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (manageable, limit 5); salivary gland: 17.6 nTPM (protected, limit 3); spleen: 16.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 16 nTPM (vital, limit 1); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161654,LSM12,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8352% (minimum 60%, Approved); adrenal gland: 53.5088% (minimum 75%, Missing); amygdala: 54.8315% (minimum 75%, Missing); basal ganglia: 59.3674% (minimum 75%, Missing); bone marrow: 45.5224% (minimum 75%, Missing); cerebellum: 59.6577% (minimum 75%, Missing); cerebral cortex: 53.8631% (minimum 75%, Missing); choroid plexus: 60.3960% (minimum 75%, Missing); colon: 56.0920% (minimum 70%, Missing); duodenum: 59.3674% (minimum 75%, Missing); esophagus: 47.1954% (minimum 70%, Missing); heart muscle: 52.6998% (minimum 75%, Missing); hippocampal formation: 56.3510% (minimum 75%, Missing); hypothalamus: 52.4731% (minimum 75%, Missing); kidney: 54.7085% (minimum 75%, Missing); liver: 46.1248% (minimum 75%, Missing); lung: 59.9509% (minimum 75%, Missing); lymph node: 54.5861% (minimum 70%, Missing); midbrain: 55.0790% (minimum 75%, Missing); pancreas: 51.2605% (minimum 75%, Missing); parathyroid gland: 53.9823% (minimum 70%, Missing); pituitary gland: 63.8743% (minimum 75%, Missing); rectum: 51.5856% (minimum 70%, Missing); retina: 44.6069% (minimum 75%, Missing); salivary gland: 58.0952% (minimum 70%, Missing); skeletal muscle: 40.5316% (minimum 75%, Missing); skin: 60.0985% (minimum 65%, Missing); small intestine: 59.8039% (minimum 75%, Missing); smooth muscle: 55.4545% (minimum 75%, Missing); spinal cord: 56.7442% (minimum 75%, Missing); spleen: 59.2233% (minimum 65%, Missing); stomach: 55.8352% (minimum 70%, Missing); thymus: 55.7078% (minimum 65%, Missing); thyroid gland: 57.9572% (minimum 65%, Missing); tongue: 51.6949% (minimum 70%, Missing); urinary bladder: 52.5862% (minimum 70%, Missing)",-0.0929224,-0.228046,-0.344684,0,2,partial,35.8,27.3,19.4,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 3); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 3); tongue: 22.8 nTPM (protected, limit 3); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 3); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 3); lymph node: 20.3 nTPM (protected, limit 3); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); adipose tissue: 19.3 nTPM (manageable, limit 10); stomach: 19.3 nTPM (protected, limit 3); colon: 19.1 nTPM (protected, limit 3); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (manageable, limit 5); salivary gland: 17.6 nTPM (protected, limit 3); spleen: 16.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 16 nTPM (vital, limit 1); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161654,LSM12,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8352% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 53.5088% (minimum 75%, Baseline (adaptation disabled)); amygdala: 54.8315% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 59.3674% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 45.5224% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 59.6577% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.8631% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.3960% (minimum 75%, Baseline (adaptation disabled)); colon: 56.0920% (minimum 70%, Baseline (adaptation disabled)); duodenum: 59.3674% (minimum 75%, Baseline (adaptation disabled)); esophagus: 47.1954% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.6998% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 56.3510% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 52.4731% (minimum 75%, Baseline (adaptation disabled)); kidney: 54.7085% (minimum 75%, Baseline (adaptation disabled)); liver: 46.1248% (minimum 75%, Baseline (adaptation disabled)); lung: 59.9509% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.5861% (minimum 70%, Baseline (adaptation disabled)); midbrain: 55.0790% (minimum 75%, Baseline (adaptation disabled)); pancreas: 51.2605% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 53.9823% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.8743% (minimum 75%, Baseline (adaptation disabled)); rectum: 51.5856% (minimum 70%, Baseline (adaptation disabled)); retina: 44.6069% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.0952% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 40.5316% (minimum 75%, Baseline (adaptation disabled)); skin: 60.0985% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.8039% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.4545% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.7442% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.2233% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.8352% (minimum 70%, Baseline (adaptation disabled)); thymus: 55.7078% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.9572% (minimum 65%, Baseline (adaptation disabled)); tongue: 51.6949% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.5862% (minimum 70%, Baseline (adaptation disabled))",-0.0929224,-0.228046,-0.344684,0,2,partial,35.8,27.3,19.4,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 3); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 3); tongue: 22.8 nTPM (protected, limit 3); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 3); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 3); lymph node: 20.3 nTPM (protected, limit 3); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); adipose tissue: 19.3 nTPM (manageable, limit 5); stomach: 19.3 nTPM (protected, limit 3); colon: 19.1 nTPM (protected, limit 3); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (manageable, limit 5); salivary gland: 17.6 nTPM (protected, limit 3); spleen: 16.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 16 nTPM (vital, limit 1); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161654,LSM12,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.6295% (minimum 99%, Missing); basal ganglia: 97.4718% (minimum 99%, Missing); duodenum: 93.5442% (minimum 99%, Missing); hypothalamus: 98.7649% (minimum 99%, Missing); midbrain: 98.1364% (minimum 99%, Missing); salivary gland: 26.3068% (minimum 97%, Missing); stomach: 80.8917% (minimum 97%, Missing)",0.05,-0.706932,-0.0545581,0,2,partial,14.9,604.8,109,"salivary gland: 604.8 nTPM (protected, limit 2); skin: 109 nTPM (manageable, limit 30); stomach: 51 nTPM (protected, limit 2); esophagus: 16 nTPM (protected, limit 12); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); salivary gland / glandular cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; salivary gland / glandular cells; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161798,AQP5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"salivary gland: 26.3068% (minimum 70%, Missing)",0.164512,-0.436932,0.185442,0,2,partial,14.9,604.8,109,"salivary gland: 604.8 nTPM (protected, limit 2); skin: 109 nTPM (manageable, limit 30); stomach: 51 nTPM (protected, limit 2); esophagus: 16 nTPM (protected, limit 12); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); salivary gland / glandular cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; salivary gland / glandular cells; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161798,AQP5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"salivary gland: 26.3068% (minimum 70%, Missing)",0.164512,-0.436932,0.185442,0,2,partial,14.9,604.8,109,"salivary gland: 604.8 nTPM (protected, limit 3); skin: 109 nTPM (manageable, limit 30); stomach: 51 nTPM (protected, limit 3); esophagus: 16 nTPM (protected, limit 12); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); salivary gland / glandular cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; salivary gland / glandular cells; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161798,AQP5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"salivary gland: 26.3068% (minimum 70%, Missing)",0.164512,-0.436932,0.185442,0,2,partial,14.9,604.8,109,"salivary gland: 604.8 nTPM (protected, limit 3); skin: 109 nTPM (manageable, limit 30); stomach: 51 nTPM (protected, limit 3); esophagus: 16 nTPM (protected, limit 12); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); salivary gland / glandular cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; salivary gland / glandular cells; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161798,AQP5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"salivary gland: 26.3068% (minimum 70%, Baseline (adaptation disabled))",0.0145122,-0.436932,0.185442,0,2,partial,14.9,604.8,109,"salivary gland: 604.8 nTPM (protected, limit 3); skin: 109 nTPM (manageable, limit 5); stomach: 51 nTPM (protected, limit 3); esophagus: 16 nTPM (protected, limit 3); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); salivary gland / glandular cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; salivary gland / glandular cells; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161798,AQP5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 25.0000% (minimum 60%, Enhanced); skin: 0.8065% (minimum 60%, Enhanced)",-0.591935,0.03,0.01,0,2,partial,0,0,12.3,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in cuticle; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161850,KRT82,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 25.0000% (minimum 50%, Enhanced); skin: 0.8065% (minimum 50%, Enhanced)",-0.491935,0.3,0.25,0,2,partial,0,0,12.3,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in cuticle; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161850,KRT82,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 25.0000% (minimum 50%, Enhanced); skin: 0.8065% (minimum 50%, Enhanced)",-0.491935,0.3,0.25,0,2,partial,0,0,12.3,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in cuticle; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161850,KRT82,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 25.0000% (minimum 50%, Enhanced); skin: 0.8065% (minimum 50%, Enhanced)",-0.491935,0.3,0.25,0,2,partial,0,0,12.3,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in cuticle; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161850,KRT82,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 25.0000% (minimum 65%, Baseline (adaptation disabled)); skin: 0.8065% (minimum 65%, Baseline (adaptation disabled))",-0.641935,0.3,0.25,0,2,partial,0,0,12.3,"skin: 12.3 nTPM (manageable, limit 5)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in cuticle; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161850,KRT82,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7358% (minimum 99%, Missing); basal ganglia: 97.3684% (minimum 99%, Missing); bone marrow: 89.0034% (minimum 95%, Enhanced); cerebellum: 91.1972% (minimum 95%, Enhanced); cerebral cortex: 94.8718% (minimum 95%, Enhanced); choroid plexus: 98.1061% (minimum 99%, Missing); hippocampal formation: 97.3684% (minimum 99%, Missing); hypothalamus: 98.1061% (minimum 99%, Missing); liver: 93.8406% (minimum 95%, Enhanced); midbrain: 97.7358% (minimum 99%, Missing); pituitary gland: 97.0037% (minimum 99%, Missing); retina: 94.8718% (minimum 99%, Missing); spinal cord: 97.3684% (minimum 99%, Missing); thymus: 93.5018% (minimum 95%, Missing)",-0.0149819,0.03,-0.0599656,0,1,partial,3.2,1.1,1.8,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161860,SYCE2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.285018,0.3,0.198718,0,1,partial,3.2,1.1,1.8,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161860,SYCE2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.285018,0.3,0.198718,0,1,partial,3.2,1.1,1.8,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161860,SYCE2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.285018,0.3,0.198718,0,1,partial,3.2,1.1,1.8,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161860,SYCE2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.285018,0.259259,0.140034,0,1,partial,3.2,1.1,1.8,"bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161860,SYCE2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0478402,0.0278402,0.00784017,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161973,CCDC42,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34784,0.29784,0.24784,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161973,CCDC42,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34784,0.29784,0.24784,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161973,CCDC42,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34784,0.29784,0.24784,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161973,CCDC42,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34784,0.29784,0.24784,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000161973,CCDC42,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.5130% (minimum 99%, Missing); basal ganglia: 98.5130% (minimum 99%, Missing); cerebral cortex: 98.5130% (minimum 99%, Missing); hypothalamus: 98.8806% (minimum 99%, Missing); kidney: 98.1481% (minimum 99%, Missing); liver: 98.8806% (minimum 99%, Missing); retina: 97.4265% (minimum 99%, Missing)",0.020696,0.0262406,-0.0157353,0,80,unavailable,0.7,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162039,MEIOB,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.320696,0.296241,0.224265,0,80,unavailable,0.7,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162039,MEIOB,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.320696,0.296241,0.224265,0,80,unavailable,0.7,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162039,MEIOB,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.320696,0.296241,0.224265,0,80,unavailable,0.7,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162039,MEIOB,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.320696,0.296241,0.224265,0,80,unavailable,0.7,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162039,MEIOB,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 85.7143% (minimum 98%, Approved); amygdala: 82.7586% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 54.5455% (minimum 98%, Approved); cerebellum: 82.7586% (minimum 98%, Approved); cerebral cortex: 70.5882% (minimum 98%, Approved); choroid plexus: 97.9592% (minimum 99%, Missing); colon: 82.7586% (minimum 95%, Approved); duodenum: 76.1905% (minimum 99%, Missing); esophagus: 68.5714% (minimum 95%, Approved); heart muscle: 85.7143% (minimum 98%, Approved); hippocampal formation: 81.3559% (minimum 99%, Missing); hypothalamus: 80.0000% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 85.7143% (minimum 98%, Approved); lung: 92.3077% (minimum 99%, Missing); lymph node: 69.5652% (minimum 97%, Missing); midbrain: 84.2105% (minimum 99%, Missing); pancreas: 88.8889% (minimum 98%, Approved); pituitary gland: 85.7143% (minimum 99%, Missing); rectum: 87.2727% (minimum 97%, Missing); retina: 96.0000% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 95%, Approved); skeletal muscle: 94.1176% (minimum 99%, Missing); skin: 84.2105% (minimum 90%, Approved); small intestine: 78.6885% (minimum 98%, Approved); smooth muscle: 94.1176% (minimum 98%, Approved); spinal cord: 88.8889% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 85.7143% (minimum 95%, Approved); thymus: 69.5652% (minimum 95%, Missing); thyroid gland: 94.1176% (minimum 95%, Missing); urinary bladder: 92.3077% (minimum 97%, Missing)",-0.254348,-0.274348,-0.434545,0,3,partial,4,2.2,2.1,"bone marrow: 4 nTPM (vital, limit 2); lymph node: 2.1 nTPM (protected, limit 2); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162062,TEDC2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 70%, Approved); lymph node: 69.5652% (minimum 70%, Missing)",0.0456522,-0.00434783,-0.154545,0,3,partial,4,2.2,2.1,"bone marrow: 4 nTPM (vital, limit 2); lymph node: 2.1 nTPM (protected, limit 2); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162062,TEDC2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 70%, Approved); lymph node: 69.5652% (minimum 70%, Missing)",0.0456522,-0.00434783,-0.154545,0,3,partial,4,2.2,2.1,"bone marrow: 4 nTPM (vital, limit 2); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162062,TEDC2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 70%, Approved); lymph node: 69.5652% (minimum 70%, Missing)",0.0456522,-0.00434783,-0.154545,0,3,partial,4,2.2,2.1,"bone marrow: 4 nTPM (vital, limit 2); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162062,TEDC2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 75.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 54.5455% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.5882% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.5714% (minimum 70%, Baseline (adaptation disabled)); lymph node: 69.5652% (minimum 70%, Baseline (adaptation disabled))",0.0456522,-0.0142857,-0.204545,0,3,partial,4,2.2,2.1,"bone marrow: 4 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162062,TEDC2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.2832% (minimum 99%, Missing); amygdala: 96.7509% (minimum 99%, Missing); basal ganglia: 96.6637% (minimum 99%, Missing); bone marrow: 92.2547% (minimum 99%, Missing); cerebellum: 97.1014% (minimum 99%, Missing); cerebral cortex: 94.0351% (minimum 99%, Missing); choroid plexus: 97.3660% (minimum 99%, Missing); duodenum: 96.8383% (minimum 99%, Missing); esophagus: 96.9259% (minimum 97%, Missing); heart muscle: 95.2043% (minimum 99%, Missing); hippocampal formation: 97.1895% (minimum 99%, Missing); hypothalamus: 97.0136% (minimum 99%, Missing); kidney: 92.8139% (minimum 99%, Missing); liver: 91.4676% (minimum 99%, Missing); lung: 97.0136% (minimum 99%, Missing); midbrain: 96.5766% (minimum 99%, Missing); pancreas: 95.0355% (minimum 99%, Missing); parathyroid gland: 93.4612% (minimum 97%, Missing); pituitary gland: 98.0787% (minimum 99%, Missing); retina: 94.6161% (minimum 99%, Missing); salivary gland: 95.1198% (minimum 97%, Missing); skeletal muscle: 92.8139% (minimum 99%, Missing); small intestine: 97.7211% (minimum 99%, Missing); smooth muscle: 95.4586% (minimum 99%, Missing); spinal cord: 97.1014% (minimum 99%, Missing); stomach: 96.8383% (minimum 97%, Missing); tongue: 94.6996% (minimum 97%, Missing)",0.00288889,-0.035388,-0.0753242,0,3,partial,10,7.5,5.3,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 2); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 2); pancreas: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162129,CLPB,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.302889,0.234612,0.164676,0,3,partial,10,7.5,5.3,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 2); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 2); pancreas: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162129,CLPB,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.302889,0.234612,0.164676,0,3,partial,10,7.5,5.3,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 3); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 3); pancreas: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); esophagus: 3.4 nTPM (protected, limit 3); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 3); cerebellum: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162129,CLPB,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.302889,0.234612,0.164676,0,3,partial,10,7.5,5.3,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 3); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 3); pancreas: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); esophagus: 3.4 nTPM (protected, limit 3); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 3); cerebellum: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162129,CLPB,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.302889,0.234612,0.164676,0,3,partial,10,7.5,5.3,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 3); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 3); pancreas: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); esophagus: 3.4 nTPM (protected, limit 3); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 3); cerebellum: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162129,CLPB,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 89.3242% (minimum 99%, Missing); basal ganglia: 84.3663% (minimum 99%, Missing); bone marrow: 94.4099% (minimum 95%, Enhanced); cerebellum: 92.8717% (minimum 95%, Enhanced); cerebral cortex: 92.7772% (minimum 95%, Enhanced); choroid plexus: 63.6872% (minimum 99%, Missing); colon: 93.6345% (minimum 97%, Missing); duodenum: 96.2025% (minimum 99%, Missing); hippocampal formation: 86.4455% (minimum 99%, Missing); hypothalamus: 86.6097% (minimum 99%, Missing); kidney: 93.5385% (minimum 95%, Enhanced); liver: 92.4012% (minimum 95%, Enhanced); lung: 89.5874% (minimum 95%, Enhanced); midbrain: 94.2149% (minimum 99%, Missing); pituitary gland: 87.0229% (minimum 99%, Missing); retina: 97.3319% (minimum 99%, Missing); small intestine: 95.0000% (minimum 99%, Missing); spinal cord: 94.6058% (minimum 99%, Missing); thymus: 93.5385% (minimum 95%, Missing)",-0.0146154,-0.033655,-0.353128,0,14,partial,52,7.1,11.1,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 6); liver: 7.5 nTPM (vital, limit 6); cerebral cortex: 7.1 nTPM (vital, limit 6); cerebellum: 7 nTPM (vital, limit 6); kidney: 6.3 nTPM (vital, limit 6); thymus: 6.3 nTPM (manageable, limit 5); colon: 6.2 nTPM (protected, limit 2); midbrain: 5.6 nTPM (vital, limit 1); spinal cord: 5.2 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162148,SAXO4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.6872% (minimum 75%, Missing)",0.285385,0.236345,-0.113128,0,14,partial,52,7.1,11.1,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 6); liver: 7.5 nTPM (vital, limit 6); cerebral cortex: 7.1 nTPM (vital, limit 6); cerebellum: 7 nTPM (vital, limit 6); kidney: 6.3 nTPM (vital, limit 6); thymus: 6.3 nTPM (manageable, limit 5); colon: 6.2 nTPM (protected, limit 2); midbrain: 5.6 nTPM (vital, limit 1); spinal cord: 5.2 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162148,SAXO4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.6872% (minimum 75%, Missing)",0.285385,0.236345,-0.113128,0,14,partial,52,7.1,11.1,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 6); liver: 7.5 nTPM (vital, limit 6); cerebral cortex: 7.1 nTPM (vital, limit 6); cerebellum: 7 nTPM (vital, limit 6); kidney: 6.3 nTPM (vital, limit 6); thymus: 6.3 nTPM (manageable, limit 5); colon: 6.2 nTPM (protected, limit 3); midbrain: 5.6 nTPM (vital, limit 1); spinal cord: 5.2 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162148,SAXO4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.6872% (minimum 75%, Missing)",0.285385,0.236345,-0.113128,0,14,partial,52,7.1,11.1,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 6); liver: 7.5 nTPM (vital, limit 6); cerebral cortex: 7.1 nTPM (vital, limit 6); cerebellum: 7 nTPM (vital, limit 6); kidney: 6.3 nTPM (vital, limit 6); thymus: 6.3 nTPM (manageable, limit 5); colon: 6.2 nTPM (protected, limit 3); midbrain: 5.6 nTPM (vital, limit 1); spinal cord: 5.2 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162148,SAXO4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.6872% (minimum 75%, Baseline (adaptation disabled))",0.241496,0.227772,-0.113128,0,14,partial,52,7.1,11.1,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); skin: 11.1 nTPM (manageable, limit 5); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); cerebral cortex: 7.1 nTPM (vital, limit 1); lymph node: 7.1 nTPM (protected, limit 3); cerebellum: 7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); colon: 6.2 nTPM (protected, limit 3); midbrain: 5.6 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); spinal cord: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); stomach: 4.1 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); duodenum: 3.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162148,SAXO4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6623% (minimum 95%, Missing); adrenal gland: 49.2754% (minimum 99%, Missing); amygdala: 52.1295% (minimum 99%, Missing); basal ganglia: 49.9184% (minimum 99%, Missing); bone marrow: 51.4286% (minimum 99%, Missing); cerebellum: 57.1963% (minimum 99%, Missing); cerebral cortex: 52.2184% (minimum 99%, Missing); choroid plexus: 48.1132% (minimum 99%, Missing); colon: 50.9151% (minimum 97%, Missing); duodenum: 63.7500% (minimum 99%, Missing); esophagus: 51.2563% (minimum 97%, Missing); heart muscle: 50.7463% (minimum 99%, Missing); hippocampal formation: 51.3423% (minimum 99%, Missing); hypothalamus: 55.0360% (minimum 99%, Missing); kidney: 52.9412% (minimum 99%, Missing); liver: 49.0385% (minimum 99%, Missing); lung: 59.6491% (minimum 99%, Missing); lymph node: 72.5118% (minimum 97%, Missing); midbrain: 49.7561% (minimum 99%, Missing); pancreas: 49.5948% (minimum 99%, Missing); parathyroid gland: 66.9584% (minimum 97%, Missing); pituitary gland: 43.6519% (minimum 99%, Missing); rectum: 77.6650% (minimum 97%, Missing); retina: 80.7388% (minimum 99%, Missing); salivary gland: 50.5785% (minimum 97%, Missing); skeletal muscle: 45.6036% (minimum 99%, Missing); skin: 47.2952% (minimum 95%, Missing); small intestine: 52.8497% (minimum 99%, Missing); smooth muscle: 71.4953% (minimum 99%, Missing); spinal cord: 50.4119% (minimum 99%, Missing); spleen: 55.2347% (minimum 95%, Missing); stomach: 50.9151% (minimum 97%, Missing); thymus: 74.0920% (minimum 95%, Missing); thyroid gland: 53.7786% (minimum 95%, Missing); tongue: 60.9562% (minimum 97%, Missing); urinary bladder: 50.4119% (minimum 97%, Missing)",-0.477048,-0.465881,-0.553481,0,7,partial,39.5,30.1,34.1,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); skin: 34.1 nTPM (manageable, limit 5); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); spinal cord: 30.1 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 2); salivary gland: 29.9 nTPM (protected, limit 2); adipose tissue: 29.8 nTPM (manageable, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 2); colon: 29.5 nTPM (protected, limit 2); esophagus: 29.1 nTPM (protected, limit 2); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (manageable, limit 5); hypothalamus: 25 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 2); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 2); thymus: 10.7 nTPM (manageable, limit 5); rectum: 8.8 nTPM (protected, limit 2); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162300,ZFPL1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6623% (minimum 65%, Missing); adrenal gland: 49.2754% (minimum 75%, Missing); amygdala: 52.1295% (minimum 75%, Missing); basal ganglia: 49.9184% (minimum 75%, Missing); bone marrow: 51.4286% (minimum 75%, Missing); cerebellum: 57.1963% (minimum 75%, Missing); cerebral cortex: 52.2184% (minimum 75%, Missing); choroid plexus: 48.1132% (minimum 75%, Missing); colon: 50.9151% (minimum 70%, Missing); duodenum: 63.7500% (minimum 75%, Missing); esophagus: 51.2563% (minimum 70%, Missing); heart muscle: 50.7463% (minimum 75%, Missing); hippocampal formation: 51.3423% (minimum 75%, Missing); hypothalamus: 55.0360% (minimum 75%, Missing); kidney: 52.9412% (minimum 75%, Missing); liver: 49.0385% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); midbrain: 49.7561% (minimum 75%, Missing); pancreas: 49.5948% (minimum 75%, Missing); parathyroid gland: 66.9584% (minimum 70%, Missing); pituitary gland: 43.6519% (minimum 75%, Missing); salivary gland: 50.5785% (minimum 70%, Missing); skeletal muscle: 45.6036% (minimum 75%, Missing); skin: 47.2952% (minimum 65%, Missing); small intestine: 52.8497% (minimum 75%, Missing); smooth muscle: 71.4953% (minimum 75%, Missing); spinal cord: 50.4119% (minimum 75%, Missing); spleen: 55.2347% (minimum 65%, Missing); stomach: 50.9151% (minimum 70%, Missing); thyroid gland: 53.7786% (minimum 65%, Missing); tongue: 60.9562% (minimum 70%, Missing); urinary bladder: 50.4119% (minimum 70%, Missing)",-0.177048,-0.195881,-0.313481,0,7,partial,39.5,30.1,34.1,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); skin: 34.1 nTPM (manageable, limit 5); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); spinal cord: 30.1 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 2); salivary gland: 29.9 nTPM (protected, limit 2); adipose tissue: 29.8 nTPM (manageable, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 2); colon: 29.5 nTPM (protected, limit 2); esophagus: 29.1 nTPM (protected, limit 2); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (manageable, limit 5); hypothalamus: 25 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 2); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 2); thymus: 10.7 nTPM (manageable, limit 5); rectum: 8.8 nTPM (protected, limit 2); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162300,ZFPL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6623% (minimum 65%, Missing); adrenal gland: 49.2754% (minimum 75%, Missing); amygdala: 52.1295% (minimum 75%, Missing); basal ganglia: 49.9184% (minimum 75%, Missing); bone marrow: 51.4286% (minimum 75%, Missing); cerebellum: 57.1963% (minimum 75%, Missing); cerebral cortex: 52.2184% (minimum 75%, Missing); choroid plexus: 48.1132% (minimum 75%, Missing); colon: 50.9151% (minimum 70%, Missing); duodenum: 63.7500% (minimum 75%, Missing); esophagus: 51.2563% (minimum 70%, Missing); heart muscle: 50.7463% (minimum 75%, Missing); hippocampal formation: 51.3423% (minimum 75%, Missing); hypothalamus: 55.0360% (minimum 75%, Missing); kidney: 52.9412% (minimum 75%, Missing); liver: 49.0385% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); midbrain: 49.7561% (minimum 75%, Missing); pancreas: 49.5948% (minimum 75%, Missing); parathyroid gland: 66.9584% (minimum 70%, Missing); pituitary gland: 43.6519% (minimum 75%, Missing); salivary gland: 50.5785% (minimum 70%, Missing); skeletal muscle: 45.6036% (minimum 75%, Missing); skin: 47.2952% (minimum 65%, Missing); small intestine: 52.8497% (minimum 75%, Missing); smooth muscle: 71.4953% (minimum 75%, Missing); spinal cord: 50.4119% (minimum 75%, Missing); spleen: 55.2347% (minimum 65%, Missing); stomach: 50.9151% (minimum 70%, Missing); thyroid gland: 53.7786% (minimum 65%, Missing); tongue: 60.9562% (minimum 70%, Missing); urinary bladder: 50.4119% (minimum 70%, Missing)",-0.177048,-0.195881,-0.313481,0,7,partial,39.5,30.1,34.1,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); skin: 34.1 nTPM (manageable, limit 5); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); spinal cord: 30.1 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 3); salivary gland: 29.9 nTPM (protected, limit 3); adipose tissue: 29.8 nTPM (manageable, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 3); colon: 29.5 nTPM (protected, limit 3); esophagus: 29.1 nTPM (protected, limit 3); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (manageable, limit 5); hypothalamus: 25 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 3); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 3); thymus: 10.7 nTPM (manageable, limit 5); rectum: 8.8 nTPM (protected, limit 3); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162300,ZFPL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6623% (minimum 65%, Missing); adrenal gland: 49.2754% (minimum 75%, Missing); amygdala: 52.1295% (minimum 75%, Missing); basal ganglia: 49.9184% (minimum 75%, Missing); bone marrow: 51.4286% (minimum 75%, Missing); cerebellum: 57.1963% (minimum 75%, Missing); cerebral cortex: 52.2184% (minimum 75%, Missing); choroid plexus: 48.1132% (minimum 75%, Missing); colon: 50.9151% (minimum 70%, Missing); duodenum: 63.7500% (minimum 75%, Missing); esophagus: 51.2563% (minimum 70%, Missing); heart muscle: 50.7463% (minimum 75%, Missing); hippocampal formation: 51.3423% (minimum 75%, Missing); hypothalamus: 55.0360% (minimum 75%, Missing); kidney: 52.9412% (minimum 75%, Missing); liver: 49.0385% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); midbrain: 49.7561% (minimum 75%, Missing); pancreas: 49.5948% (minimum 75%, Missing); parathyroid gland: 66.9584% (minimum 70%, Missing); pituitary gland: 43.6519% (minimum 75%, Missing); salivary gland: 50.5785% (minimum 70%, Missing); skeletal muscle: 45.6036% (minimum 75%, Missing); skin: 47.2952% (minimum 65%, Missing); small intestine: 52.8497% (minimum 75%, Missing); smooth muscle: 71.4953% (minimum 75%, Missing); spinal cord: 50.4119% (minimum 75%, Missing); spleen: 55.2347% (minimum 65%, Missing); stomach: 50.9151% (minimum 70%, Missing); thyroid gland: 53.7786% (minimum 65%, Missing); tongue: 60.9562% (minimum 70%, Missing); urinary bladder: 50.4119% (minimum 70%, Missing)",-0.177048,-0.195881,-0.313481,0,7,partial,39.5,30.1,34.1,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); skin: 34.1 nTPM (manageable, limit 5); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); spinal cord: 30.1 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 3); salivary gland: 29.9 nTPM (protected, limit 3); adipose tissue: 29.8 nTPM (manageable, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 3); colon: 29.5 nTPM (protected, limit 3); esophagus: 29.1 nTPM (protected, limit 3); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (manageable, limit 5); hypothalamus: 25 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 3); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 3); thymus: 10.7 nTPM (manageable, limit 5); rectum: 8.8 nTPM (protected, limit 3); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162300,ZFPL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6623% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 49.2754% (minimum 75%, Baseline (adaptation disabled)); amygdala: 52.1295% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 49.9184% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 51.4286% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.1963% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 52.2184% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 48.1132% (minimum 75%, Baseline (adaptation disabled)); colon: 50.9151% (minimum 70%, Baseline (adaptation disabled)); duodenum: 63.7500% (minimum 75%, Baseline (adaptation disabled)); esophagus: 51.2563% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 50.7463% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 51.3423% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.0360% (minimum 75%, Baseline (adaptation disabled)); kidney: 52.9412% (minimum 75%, Baseline (adaptation disabled)); liver: 49.0385% (minimum 75%, Baseline (adaptation disabled)); lung: 59.6491% (minimum 75%, Baseline (adaptation disabled)); midbrain: 49.7561% (minimum 75%, Baseline (adaptation disabled)); pancreas: 49.5948% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.9584% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 43.6519% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.5785% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 45.6036% (minimum 75%, Baseline (adaptation disabled)); skin: 47.2952% (minimum 65%, Baseline (adaptation disabled)); small intestine: 52.8497% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.4953% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.4119% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.2347% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.9151% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.7786% (minimum 65%, Baseline (adaptation disabled)); tongue: 60.9562% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 50.4119% (minimum 70%, Baseline (adaptation disabled))",-0.177048,-0.195881,-0.313481,0,7,partial,39.5,30.1,34.1,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); skin: 34.1 nTPM (manageable, limit 5); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); spinal cord: 30.1 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 3); salivary gland: 29.9 nTPM (protected, limit 3); adipose tissue: 29.8 nTPM (manageable, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 3); colon: 29.5 nTPM (protected, limit 3); esophagus: 29.1 nTPM (protected, limit 3); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (manageable, limit 5); hypothalamus: 25 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 3); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 3); thymus: 10.7 nTPM (manageable, limit 5); rectum: 8.8 nTPM (protected, limit 3); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162300,ZFPL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7677% (minimum 95%, Missing); adrenal gland: 92.7171% (minimum 99%, Missing); amygdala: 98.8060% (minimum 99%, Missing); basal ganglia: 98.5119% (minimum 99%, Missing); bone marrow: 72.5877% (minimum 99%, Missing); cerebellum: 85.9740% (minimum 99%, Missing); cerebral cortex: 97.0674% (minimum 99%, Missing); colon: 94.0341% (minimum 97%, Missing); duodenum: 90.9341% (minimum 99%, Missing); esophagus: 96.2209% (minimum 97%, Missing); heart muscle: 95.6647% (minimum 99%, Missing); hippocampal formation: 98.5119% (minimum 99%, Missing); hypothalamus: 98.8060% (minimum 99%, Missing); kidney: 94.5714% (minimum 99%, Missing); liver: 92.7171% (minimum 99%, Missing); lung: 92.7171% (minimum 99%, Missing); lymph node: 89.9457% (minimum 97%, Missing); midbrain: 98.8060% (minimum 99%, Missing); pancreas: 94.0341% (minimum 99%, Missing); pituitary gland: 95.3890% (minimum 99%, Missing); retina: 88.7399% (minimum 99%, Missing); salivary gland: 93.5028% (minimum 97%, Missing); skeletal muscle: 91.9444% (minimum 99%, Missing); skin: 87.7984% (minimum 95%, Missing); small intestine: 89.4595% (minimum 99%, Missing); spinal cord: 98.5119% (minimum 99%, Missing); spleen: 88.7399% (minimum 95%, Missing); stomach: 94.0341% (minimum 97%, Missing); thyroid gland: 93.7677% (minimum 95%, Missing); urinary bladder: 95.1149% (minimum 97%, Missing)",-0.0720159,-0.0705435,-0.264123,0,80,unavailable,12.5,3.7,4.6,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); stomach: 2.1 nTPM (protected, limit 2); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162526,TSSK3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.5877% (minimum 75%, Missing)",0.227984,0.199457,-0.0241228,0,80,unavailable,12.5,3.7,4.6,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); stomach: 2.1 nTPM (protected, limit 2); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162526,TSSK3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.5877% (minimum 75%, Missing)",0.227984,0.199457,-0.0241228,0,80,unavailable,12.5,3.7,4.6,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162526,TSSK3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.5877% (minimum 75%, Missing)",0.227984,0.199457,-0.0241228,0,80,unavailable,12.5,3.7,4.6,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162526,TSSK3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.5877% (minimum 75%, Baseline (adaptation disabled))",0.227984,0.199457,-0.0241228,0,80,unavailable,12.5,3.7,4.6,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162526,TSSK3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.3684% (minimum 99%, Missing); amygdala: 97.1717% (minimum 99%, Missing); basal ganglia: 95.2475% (minimum 99%, Missing); bone marrow: 96.0080% (minimum 99%, Missing); cerebellum: 97.7642% (minimum 99%, Missing); cerebral cortex: 94.1292% (minimum 99%, Missing); choroid plexus: 67.5562% (minimum 99%, Missing); colon: 83.7979% (minimum 97%, Missing); duodenum: 98.3640% (minimum 99%, Missing); esophagus: 92.5000% (minimum 97%, Missing); heart muscle: 93.3981% (minimum 99%, Missing); hippocampal formation: 95.8167% (minimum 99%, Missing); hypothalamus: 94.4990% (minimum 99%, Missing); kidney: 96.0080% (minimum 99%, Missing); liver: 89.4052% (minimum 99%, Missing); lung: 90.4135% (minimum 99%, Missing); midbrain: 95.6262% (minimum 99%, Missing); pancreas: 96.9758% (minimum 99%, Missing); parathyroid gland: 91.0985% (minimum 97%, Missing); pituitary gland: 94.3137% (minimum 99%, Missing); rectum: 91.2713% (minimum 97%, Missing); retina: 95.8167% (minimum 99%, Missing); small intestine: 96.2000% (minimum 99%, Missing); smooth muscle: 93.7622% (minimum 99%, Missing); spinal cord: 97.9633% (minimum 99%, Missing); stomach: 95.6262% (minimum 97%, Missing); thyroid gland: 90.0749% (minimum 95%, Missing); urinary bladder: 95.0593% (minimum 97%, Missing)",-0.0492509,-0.132021,-0.314438,0,2,partial,23.1,9.3,5.3,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 2); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lung: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); esophagus: 3.9 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162543,UBXN10,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 67.5562% (minimum 75%, Missing)",0.250749,0.137979,-0.0744382,0,2,partial,23.1,9.3,5.3,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 2); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lung: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); esophagus: 3.9 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162543,UBXN10,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 67.5562% (minimum 75%, Missing)",0.250749,0.137979,-0.0744382,0,2,partial,23.1,9.3,5.3,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 3); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lung: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); esophagus: 3.9 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162543,UBXN10,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 67.5562% (minimum 75%, Missing)",0.250749,0.137979,-0.0744382,0,2,partial,23.1,9.3,5.3,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 3); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lung: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); esophagus: 3.9 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162543,UBXN10,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 67.5562% (minimum 75%, Baseline (adaptation disabled))",0.250749,0.137979,-0.0744382,0,2,partial,23.1,9.3,5.3,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 3); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lung: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); esophagus: 3.9 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162543,UBXN10,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 93.3638% (minimum 99%, Missing); hypothalamus: 98.7893% (minimum 99%, Missing); lung: 93.7931% (minimum 99%, Missing); pituitary gland: 95.3271% (minimum 99%, Missing)",0.0214286,0.0178935,-0.0563616,0,80,unavailable,2.9,0.5,1.2,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162571,TTLL10,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321429,0.287893,0.183638,0,80,unavailable,2.9,0.5,1.2,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162571,TTLL10,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321429,0.287893,0.183638,0,80,unavailable,2.9,0.5,1.2,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162571,TTLL10,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321429,0.287893,0.183638,0,80,unavailable,2.9,0.5,1.2,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162571,TTLL10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321429,0.287893,0.183638,0,80,unavailable,2.9,0.5,1.2,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162571,TTLL10,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 98.8024% (minimum 99%, Missing)",0.0439759,0.0239759,-0.00197605,0,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162592,CCDC27,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343976,0.293976,0.238024,0,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162592,CCDC27,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343976,0.293976,0.238024,0,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162592,CCDC27,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343976,0.293976,0.238024,0,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162592,CCDC27,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343976,0.293976,0.238024,0,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162592,CCDC27,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.5854% (minimum 98%, Approved); amygdala: 98.5075% (minimum 99%, Missing); basal ganglia: 98.5075% (minimum 99%, Missing); choroid plexus: 92.0930% (minimum 99%, Missing); hippocampal formation: 98.5075% (minimum 99%, Missing); hypothalamus: 97.5369% (minimum 99%, Missing); kidney: 91.2442% (minimum 99%, Missing); liver: 95.6522% (minimum 98%, Approved); midbrain: 97.0588% (minimum 99%, Missing); parathyroid gland: 94.2857% (minimum 97%, Missing); pituitary gland: 97.5369% (minimum 99%, Missing); retina: 97.5369% (minimum 99%, Missing); spinal cord: 97.0588% (minimum 99%, Missing)",0.00652174,-0.0271429,-0.0775576,0,6,partial,1.9,1.2,1.6,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162620,LRRIQ3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.306522,0.242857,0.162442,0,6,partial,1.9,1.2,1.6,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162620,LRRIQ3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.306522,0.242857,0.162442,0,6,partial,1.9,1.2,1.6,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162620,LRRIQ3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.306522,0.242857,0.162442,0,6,partial,1.9,1.2,1.6,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162620,LRRIQ3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.275234,0.242857,0.162442,0,6,partial,1.9,1.2,1.6,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162620,LRRIQ3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 43.4783% (minimum 99%, Missing); esophagus: 58.8235% (minimum 97%, Missing); hypothalamus: 76.9231% (minimum 99%, Missing); salivary gland: 27.7778% (minimum 97%, Missing); thyroid gland: 83.3333% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 66.6667% (minimum 97%, Missing)",-0.116667,-0.692222,-0.555217,0,80,unavailable,1.3,2.6,0.2,"salivary gland: 2.6 nTPM (protected, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162624,LHX8,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 43.4783% (minimum 75%, Missing); esophagus: 58.8235% (minimum 70%, Missing); salivary gland: 27.7778% (minimum 70%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",0.183333,-0.422222,-0.315217,0,80,unavailable,1.3,2.6,0.2,"salivary gland: 2.6 nTPM (protected, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162624,LHX8,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 43.4783% (minimum 75%, Missing); esophagus: 58.8235% (minimum 70%, Missing); salivary gland: 27.7778% (minimum 70%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",0.183333,-0.422222,-0.315217,0,80,unavailable,1.3,2.6,0.2,"basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162624,LHX8,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 43.4783% (minimum 75%, Missing); esophagus: 58.8235% (minimum 70%, Missing); salivary gland: 27.7778% (minimum 70%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",0.183333,-0.422222,-0.315217,0,80,unavailable,1.3,2.6,0.2,"basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162624,LHX8,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 43.4783% (minimum 75%, Baseline (adaptation disabled)); esophagus: 58.8235% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 27.7778% (minimum 70%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 66.6667% (minimum 70%, Baseline (adaptation disabled))",0.183333,-0.422222,-0.315217,0,80,unavailable,1.3,2.6,0.2,"basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162624,LHX8,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.0759% (minimum 95%, Uncertain); adrenal gland: 96.0165% (minimum 99%, Missing); amygdala: 89.8458% (minimum 99%, Missing); basal ganglia: 87.2659% (minimum 99%, Missing); bone marrow: 84.2169% (minimum 99%, Uncertain); cerebellum: 94.3320% (minimum 99%, Missing); cerebral cortex: 86.0837% (minimum 99%, Missing); choroid plexus: 98.3122% (minimum 99%, Missing); colon: 91.7323% (minimum 97%, Missing); duodenum: 93.5743% (minimum 99%, Missing); esophagus: 96.4138% (minimum 97%, Missing); heart muscle: 97.6257% (minimum 99%, Uncertain); hippocampal formation: 90.4269% (minimum 99%, Missing); hypothalamus: 84.9332% (minimum 99%, Missing); kidney: 95.4918% (minimum 99%, Missing); liver: 97.3538% (minimum 99%, Uncertain); lung: 93.8255% (minimum 99%, Missing); lymph node: 84.2169% (minimum 97%, Missing); midbrain: 87.8141% (minimum 99%, Missing); pancreas: 97.2184% (minimum 99%, Missing); pituitary gland: 93.2000% (minimum 99%, Missing); rectum: 88.3692% (minimum 97%, Missing); retina: 96.0165% (minimum 99%, Missing); salivary gland: 96.0165% (minimum 97%, Missing); skeletal muscle: 95.7534% (minimum 99%, Missing); skin: 94.9728% (minimum 95%, Missing); small intestine: 90.4269% (minimum 99%, Missing); smooth muscle: 95.3615% (minimum 99%, Missing); spinal cord: 88.2576% (minimum 99%, Missing); spleen: 86.6171% (minimum 95%, Missing); stomach: 93.8255% (minimum 97%, Missing); thymus: 79.3417% (minimum 95%, Missing); tongue: 92.2164% (minimum 97%, Missing); urinary bladder: 92.0949% (minimum 97%, Missing)",-0.156583,-0.127831,-0.147831,0,2,partial,13.1,13.1,18.2,"thymus: 18.2 nTPM (manageable, limit 5); lymph node: 13.1 nTPM (protected, limit 2); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); spleen: 10.8 nTPM (manageable, limit 5); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 2); amygdala: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); urinary bladder: 6 nTPM (protected, limit 2); tongue: 5.9 nTPM (protected, limit 2); adipose tissue: 5.2 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162639,HENMT1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.143417,0.142169,0.0921687,0,2,partial,13.1,13.1,18.2,"thymus: 18.2 nTPM (manageable, limit 5); lymph node: 13.1 nTPM (protected, limit 2); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); spleen: 10.8 nTPM (manageable, limit 5); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 2); amygdala: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); urinary bladder: 6 nTPM (protected, limit 2); tongue: 5.9 nTPM (protected, limit 2); adipose tissue: 5.2 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162639,HENMT1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.143417,0.142169,0.0921687,0,2,partial,13.1,13.1,18.2,"thymus: 18.2 nTPM (manageable, limit 5); lymph node: 13.1 nTPM (protected, limit 3); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); spleen: 10.8 nTPM (manageable, limit 5); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 3); amygdala: 7.9 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); urinary bladder: 6 nTPM (protected, limit 3); tongue: 5.9 nTPM (protected, limit 3); adipose tissue: 5.2 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162639,HENMT1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.143417,0.142169,0.0921687,0,2,partial,13.1,13.1,18.2,"thymus: 18.2 nTPM (manageable, limit 5); lymph node: 13.1 nTPM (protected, limit 3); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); spleen: 10.8 nTPM (manageable, limit 5); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 3); amygdala: 7.9 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); urinary bladder: 6 nTPM (protected, limit 3); tongue: 5.9 nTPM (protected, limit 3); adipose tissue: 5.2 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162639,HENMT1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.143417,0.142169,0.0921687,0,2,partial,13.1,13.1,18.2,"thymus: 18.2 nTPM (manageable, limit 5); lymph node: 13.1 nTPM (protected, limit 3); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); spleen: 10.8 nTPM (manageable, limit 5); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 3); amygdala: 7.9 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); urinary bladder: 6 nTPM (protected, limit 3); tongue: 5.9 nTPM (protected, limit 3); adipose tissue: 5.2 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162639,HENMT1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 94.0000% (minimum 95%, Missing)",-0.01,0.03,0.01,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162641,AKNAD1,admission_only,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.29,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162641,AKNAD1,selectivity_revised,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.29,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162641,AKNAD1,grid_revised,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.29,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162641,AKNAD1,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.29,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162641,AKNAD1,current_fixed,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.3051% (minimum 99%, Missing); choroid plexus: 87.8788% (minimum 99%, Missing); hippocampal formation: 98.3051% (minimum 99%, Missing); pituitary gland: 98.3051% (minimum 99%, Missing); retina: 95.0820% (minimum 99%, Missing)",0.05,0.03,-0.111212,0,10,partial,0.8,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162753,SLC9C2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.128788,0,10,partial,0.8,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162753,SLC9C2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.128788,0,10,partial,0.8,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162753,SLC9C2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.128788,0,10,partial,0.8,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162753,SLC9C2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.316667,0.283051,0.128788,0,10,partial,0.8,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162753,SLC9C2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 84.3750% (minimum 99%, Missing); heart muscle: 97.5904% (minimum 99%, Missing); kidney: 97.5904% (minimum 99%, Missing); parathyroid gland: 80.5970% (minimum 97%, Missing); pituitary gland: 98.7805% (minimum 99%, Missing); skeletal muscle: 92.5714% (minimum 99%, Missing)",0.05,-0.16403,-0.14625,0,80,unavailable,3,3.9,0,"parathyroid gland: 3.9 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162763,LRRC52,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.10597,0.09375,0,80,unavailable,3,3.9,0,"parathyroid gland: 3.9 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162763,LRRC52,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.10597,0.09375,0,80,unavailable,3,3.9,0,"parathyroid gland: 3.9 nTPM (protected, limit 3); choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162763,LRRC52,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.10597,0.09375,0,80,unavailable,3,3.9,0,"parathyroid gland: 3.9 nTPM (protected, limit 3); choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162763,LRRC52,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.10597,0.09375,0,80,unavailable,3,3.9,0,"parathyroid gland: 3.9 nTPM (protected, limit 3); choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162763,LRRC52,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0486945,0.03,0.01,0,4,partial,0.4,0.3,0.7,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162771,GARIN4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348695,0.3,0.25,0,4,partial,0.4,0.3,0.7,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162771,GARIN4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348695,0.3,0.25,0,4,partial,0.4,0.3,0.7,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162771,GARIN4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348695,0.3,0.25,0,4,partial,0.4,0.3,0.7,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162771,GARIN4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340933,0.296094,0.244798,0,4,partial,0.4,0.3,0.7,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162771,GARIN4,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 98.0769% (minimum 99%, Missing); retina: 98.7097% (minimum 99%, Missing)",0.05,0.03,-0.00923077,0,3,partial,0.3,0.2,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162779,AXDND1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.230769,0,3,partial,0.3,0.2,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162779,AXDND1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.230769,0,3,partial,0.3,0.2,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162779,AXDND1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.230769,0,3,partial,0.3,0.2,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162779,AXDND1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.343506,0.287097,0.230769,0,3,partial,0.3,0.2,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162779,AXDND1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.8037% (minimum 99%, Missing); basal ganglia: 90.2128% (minimum 99%, Missing); hippocampal formation: 97.6959% (minimum 99%, Missing); hypothalamus: 95.9276% (minimum 99%, Missing); kidney: 92.1739% (minimum 99%, Missing); midbrain: 97.2477% (minimum 99%, Missing); pituitary gland: 90.5983% (minimum 99%, Missing); retina: 98.6047% (minimum 99%, Missing)",0.0453052,0.03,-0.0878723,0,4,partial,2.3,0.8,0.8,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162782,TDRD5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.345305,0.3,0.152128,0,4,partial,2.3,0.8,0.8,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162782,TDRD5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.345305,0.3,0.152128,0,4,partial,2.3,0.8,0.8,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162782,TDRD5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.345305,0.3,0.152128,0,4,partial,2.3,0.8,0.8,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162782,TDRD5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.313636,0.263636,0.152128,0,4,partial,2.3,0.8,0.8,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162782,TDRD5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.0588% (minimum 99%, Missing); basal ganglia: 95.1923% (minimum 99%, Missing); bone marrow: 85.3448% (minimum 95%, Enhanced); choroid plexus: 78.5714% (minimum 99%, Missing); hippocampal formation: 96.1165% (minimum 99%, Missing); hypothalamus: 94.2857% (minimum 99%, Missing); kidney: 93.3962% (minimum 99%, Missing); parathyroid gland: 79.8387% (minimum 97%, Missing); pituitary gland: 96.1165% (minimum 99%, Missing); retina: 86.0870% (minimum 99%, Missing); skeletal muscle: 83.1933% (minimum 95%, Enhanced)",0.04,-0.171613,-0.204286,0,6,partial,2.7,2.5,0.7,"choroid plexus: 2.7 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162814,SPATA17,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.34,0.0983871,0.0357143,0,6,partial,2.7,2.5,0.7,"choroid plexus: 2.7 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162814,SPATA17,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.34,0.0983871,0.0357143,0,6,partial,2.7,2.5,0.7,"choroid plexus: 2.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162814,SPATA17,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.34,0.0983871,0.0357143,0,6,partial,2.7,2.5,0.7,"choroid plexus: 2.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162814,SPATA17,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.283962,0.0983871,0.0357143,0,6,partial,2.7,2.5,0.7,"choroid plexus: 2.7 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162814,SPATA17,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 95.8333% (minimum 99%, Missing); duodenum: 95.8333% (minimum 99%, Missing); small intestine: 95.8333% (minimum 99%, Missing)",0.05,0.03,-0.0316667,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162843,WDR64,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162843,WDR64,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162843,WDR64,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162843,WDR64,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162843,WDR64,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.8008% (minimum 95%, Missing); adrenal gland: 40.0641% (minimum 99%, Missing); amygdala: 67.5676% (minimum 99%, Missing); basal ganglia: 58.4112% (minimum 99%, Missing); bone marrow: 35.0140% (minimum 99%, Missing); cerebellum: 42.5170% (minimum 99%, Missing); cerebral cortex: 44.6429% (minimum 99%, Missing); choroid plexus: 48.8281% (minimum 99%, Missing); colon: 48.4496% (minimum 97%, Missing); duodenum: 55.8036% (minimum 99%, Missing); esophagus: 43.7063% (minimum 97%, Missing); heart muscle: 59.5238% (minimum 99%, Missing); hippocampal formation: 66.4894% (minimum 99%, Missing); hypothalamus: 51.8672% (minimum 99%, Missing); kidney: 60.0962% (minimum 99%, Missing); liver: 35.4108% (minimum 99%, Missing); lung: 56.5611% (minimum 99%, Missing); lymph node: 43.4028% (minimum 97%, Missing); midbrain: 63.4518% (minimum 99%, Missing); pancreas: 55.8036% (minimum 99%, Missing); parathyroid gland: 53.4188% (minimum 97%, Missing); pituitary gland: 63.1313% (minimum 99%, Missing); rectum: 51.8672% (minimum 97%, Missing); retina: 43.5540% (minimum 99%, Missing); salivary gland: 64.1026% (minimum 95%, Approved); skeletal muscle: 28.9352% (minimum 99%, Missing); skin: 55.8036% (minimum 95%, Missing); small intestine: 49.4071% (minimum 99%, Missing); smooth muscle: 56.3063% (minimum 99%, Missing); spinal cord: 71.0227% (minimum 99%, Missing); spleen: 55.0661% (minimum 95%, Missing); stomach: 60.3865% (minimum 97%, Missing); thymus: 47.3485% (minimum 95%, Missing); thyroid gland: 48.0769% (minimum 95%, Missing); tongue: 25.0501% (minimum 97%, Missing); urinary bladder: 53.4188% (minimum 97%, Missing)",-0.476515,-0.719499,-0.700648,0,2,partial,30.7,37.4,13.9,"tongue: 37.4 nTPM (protected, limit 2); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 2); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); thymus: 13.9 nTPM (manageable, limit 5); thyroid gland: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 2); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 2); parathyroid gland: 10.9 nTPM (protected, limit 2); urinary bladder: 10.9 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); skin: 9.9 nTPM (manageable, limit 5); duodenum: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 2); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 4); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162852,CNST,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.8008% (minimum 65%, Missing); adrenal gland: 40.0641% (minimum 75%, Missing); amygdala: 67.5676% (minimum 75%, Missing); basal ganglia: 58.4112% (minimum 75%, Missing); bone marrow: 35.0140% (minimum 75%, Missing); cerebellum: 42.5170% (minimum 75%, Missing); cerebral cortex: 44.6429% (minimum 75%, Missing); choroid plexus: 48.8281% (minimum 75%, Missing); colon: 48.4496% (minimum 70%, Missing); duodenum: 55.8036% (minimum 75%, Missing); esophagus: 43.7063% (minimum 70%, Missing); heart muscle: 59.5238% (minimum 75%, Missing); hippocampal formation: 66.4894% (minimum 75%, Missing); hypothalamus: 51.8672% (minimum 75%, Missing); kidney: 60.0962% (minimum 75%, Missing); liver: 35.4108% (minimum 75%, Missing); lung: 56.5611% (minimum 75%, Missing); lymph node: 43.4028% (minimum 70%, Missing); midbrain: 63.4518% (minimum 75%, Missing); pancreas: 55.8036% (minimum 75%, Missing); parathyroid gland: 53.4188% (minimum 70%, Missing); pituitary gland: 63.1313% (minimum 75%, Missing); rectum: 51.8672% (minimum 70%, Missing); retina: 43.5540% (minimum 75%, Missing); salivary gland: 64.1026% (minimum 65%, Approved); skeletal muscle: 28.9352% (minimum 75%, Missing); skin: 55.8036% (minimum 65%, Missing); small intestine: 49.4071% (minimum 75%, Missing); smooth muscle: 56.3063% (minimum 75%, Missing); spinal cord: 71.0227% (minimum 75%, Missing); spleen: 55.0661% (minimum 65%, Missing); stomach: 60.3865% (minimum 70%, Missing); thymus: 47.3485% (minimum 65%, Missing); thyroid gland: 48.0769% (minimum 65%, Missing); tongue: 25.0501% (minimum 70%, Missing); urinary bladder: 53.4188% (minimum 70%, Missing)",-0.176515,-0.449499,-0.460648,0,2,partial,30.7,37.4,13.9,"tongue: 37.4 nTPM (protected, limit 2); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 2); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); thymus: 13.9 nTPM (manageable, limit 5); thyroid gland: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 2); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 2); parathyroid gland: 10.9 nTPM (protected, limit 2); urinary bladder: 10.9 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); skin: 9.9 nTPM (manageable, limit 5); duodenum: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 2); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 4); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162852,CNST,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.8008% (minimum 65%, Missing); adrenal gland: 40.0641% (minimum 75%, Missing); amygdala: 67.5676% (minimum 75%, Missing); basal ganglia: 58.4112% (minimum 75%, Missing); bone marrow: 35.0140% (minimum 75%, Missing); cerebellum: 42.5170% (minimum 75%, Missing); cerebral cortex: 44.6429% (minimum 75%, Missing); choroid plexus: 48.8281% (minimum 75%, Missing); colon: 48.4496% (minimum 70%, Missing); duodenum: 55.8036% (minimum 75%, Missing); esophagus: 43.7063% (minimum 70%, Missing); heart muscle: 59.5238% (minimum 75%, Missing); hippocampal formation: 66.4894% (minimum 75%, Missing); hypothalamus: 51.8672% (minimum 75%, Missing); kidney: 60.0962% (minimum 75%, Missing); liver: 35.4108% (minimum 75%, Missing); lung: 56.5611% (minimum 75%, Missing); lymph node: 43.4028% (minimum 70%, Missing); midbrain: 63.4518% (minimum 75%, Missing); pancreas: 55.8036% (minimum 75%, Missing); parathyroid gland: 53.4188% (minimum 70%, Missing); pituitary gland: 63.1313% (minimum 75%, Missing); rectum: 51.8672% (minimum 70%, Missing); retina: 43.5540% (minimum 75%, Missing); salivary gland: 64.1026% (minimum 65%, Approved); skeletal muscle: 28.9352% (minimum 75%, Missing); skin: 55.8036% (minimum 65%, Missing); small intestine: 49.4071% (minimum 75%, Missing); smooth muscle: 56.3063% (minimum 75%, Missing); spinal cord: 71.0227% (minimum 75%, Missing); spleen: 55.0661% (minimum 65%, Missing); stomach: 60.3865% (minimum 70%, Missing); thymus: 47.3485% (minimum 65%, Missing); thyroid gland: 48.0769% (minimum 65%, Missing); tongue: 25.0501% (minimum 70%, Missing); urinary bladder: 53.4188% (minimum 70%, Missing)",-0.176515,-0.449499,-0.460648,0,2,partial,30.7,37.4,13.9,"tongue: 37.4 nTPM (protected, limit 3); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 3); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 3); cerebral cortex: 15.5 nTPM (vital, limit 1); thymus: 13.9 nTPM (manageable, limit 5); thyroid gland: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 3); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 3); parathyroid gland: 10.9 nTPM (protected, limit 3); urinary bladder: 10.9 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); skin: 9.9 nTPM (manageable, limit 5); duodenum: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 3); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 4); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162852,CNST,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.8008% (minimum 65%, Missing); adrenal gland: 40.0641% (minimum 75%, Missing); amygdala: 67.5676% (minimum 75%, Missing); basal ganglia: 58.4112% (minimum 75%, Missing); bone marrow: 35.0140% (minimum 75%, Missing); cerebellum: 42.5170% (minimum 75%, Missing); cerebral cortex: 44.6429% (minimum 75%, Missing); choroid plexus: 48.8281% (minimum 75%, Missing); colon: 48.4496% (minimum 70%, Missing); duodenum: 55.8036% (minimum 75%, Missing); esophagus: 43.7063% (minimum 70%, Missing); heart muscle: 59.5238% (minimum 75%, Missing); hippocampal formation: 66.4894% (minimum 75%, Missing); hypothalamus: 51.8672% (minimum 75%, Missing); kidney: 60.0962% (minimum 75%, Missing); liver: 35.4108% (minimum 75%, Missing); lung: 56.5611% (minimum 75%, Missing); lymph node: 43.4028% (minimum 70%, Missing); midbrain: 63.4518% (minimum 75%, Missing); pancreas: 55.8036% (minimum 75%, Missing); parathyroid gland: 53.4188% (minimum 70%, Missing); pituitary gland: 63.1313% (minimum 75%, Missing); rectum: 51.8672% (minimum 70%, Missing); retina: 43.5540% (minimum 75%, Missing); salivary gland: 64.1026% (minimum 65%, Approved); skeletal muscle: 28.9352% (minimum 75%, Missing); skin: 55.8036% (minimum 65%, Missing); small intestine: 49.4071% (minimum 75%, Missing); smooth muscle: 56.3063% (minimum 75%, Missing); spinal cord: 71.0227% (minimum 75%, Missing); spleen: 55.0661% (minimum 65%, Missing); stomach: 60.3865% (minimum 70%, Missing); thymus: 47.3485% (minimum 65%, Missing); thyroid gland: 48.0769% (minimum 65%, Missing); tongue: 25.0501% (minimum 70%, Missing); urinary bladder: 53.4188% (minimum 70%, Missing)",-0.176515,-0.449499,-0.460648,0,2,partial,30.7,37.4,13.9,"tongue: 37.4 nTPM (protected, limit 3); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 3); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 3); cerebral cortex: 15.5 nTPM (vital, limit 1); thymus: 13.9 nTPM (manageable, limit 5); thyroid gland: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 3); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 3); parathyroid gland: 10.9 nTPM (protected, limit 3); urinary bladder: 10.9 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); skin: 9.9 nTPM (manageable, limit 5); duodenum: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 3); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 4); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162852,CNST,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.8008% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 40.0641% (minimum 75%, Baseline (adaptation disabled)); amygdala: 67.5676% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.4112% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 35.0140% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 42.5170% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 44.6429% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 48.8281% (minimum 75%, Baseline (adaptation disabled)); colon: 48.4496% (minimum 70%, Baseline (adaptation disabled)); duodenum: 55.8036% (minimum 75%, Baseline (adaptation disabled)); esophagus: 43.7063% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.5238% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 66.4894% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 51.8672% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.0962% (minimum 75%, Baseline (adaptation disabled)); liver: 35.4108% (minimum 75%, Baseline (adaptation disabled)); lung: 56.5611% (minimum 75%, Baseline (adaptation disabled)); lymph node: 43.4028% (minimum 70%, Baseline (adaptation disabled)); midbrain: 63.4518% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.8036% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 53.4188% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.1313% (minimum 75%, Baseline (adaptation disabled)); rectum: 51.8672% (minimum 70%, Baseline (adaptation disabled)); retina: 43.5540% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.1026% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 28.9352% (minimum 75%, Baseline (adaptation disabled)); skin: 55.8036% (minimum 65%, Baseline (adaptation disabled)); small intestine: 49.4071% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.3063% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.0227% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.0661% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.3865% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.3485% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 48.0769% (minimum 65%, Baseline (adaptation disabled)); tongue: 25.0501% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 53.4188% (minimum 70%, Baseline (adaptation disabled))",-0.176515,-0.449499,-0.460648,0,2,partial,30.7,37.4,13.9,"tongue: 37.4 nTPM (protected, limit 3); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 3); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 3); cerebral cortex: 15.5 nTPM (vital, limit 1); thymus: 13.9 nTPM (manageable, limit 5); thyroid gland: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 3); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 3); parathyroid gland: 10.9 nTPM (protected, limit 3); urinary bladder: 10.9 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); skin: 9.9 nTPM (manageable, limit 5); duodenum: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 3); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 3); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162852,CNST,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.1814% (minimum 95%, Missing); adrenal gland: 65.0224% (minimum 99%, Missing); amygdala: 66.5138% (minimum 99%, Missing); basal ganglia: 67.4419% (minimum 99%, Missing); bone marrow: 66.5138% (minimum 99%, Missing); cerebellum: 70.7317% (minimum 99%, Missing); cerebral cortex: 68.7204% (minimum 99%, Missing); choroid plexus: 65.9091% (minimum 99%, Missing); colon: 59.4262% (minimum 97%, Missing); duodenum: 59.4262% (minimum 99%, Missing); esophagus: 59.4262% (minimum 97%, Missing); heart muscle: 55.7692% (minimum 99%, Missing); hippocampal formation: 68.7204% (minimum 99%, Missing); hypothalamus: 67.4419% (minimum 99%, Missing); kidney: 52.5362% (minimum 99%, Missing); liver: 37.3711% (minimum 99%, Missing); lung: 61.7021% (minimum 99%, Missing); lymph node: 68.7204% (minimum 97%, Missing); midbrain: 67.7570% (minimum 99%, Missing); pancreas: 55.9846% (minimum 99%, Missing); parathyroid gland: 61.1814% (minimum 97%, Missing); pituitary gland: 66.8203% (minimum 99%, Missing); rectum: 58.4677% (minimum 97%, Missing); retina: 63.0435% (minimum 99%, Missing); salivary gland: 63.3188% (minimum 97%, Missing); skeletal muscle: 50.6993% (minimum 99%, Missing); skin: 65.6109% (minimum 95%, Missing); small intestine: 60.4167% (minimum 99%, Missing); smooth muscle: 65.0224% (minimum 99%, Missing); spinal cord: 65.3153% (minimum 99%, Missing); spleen: 69.0476% (minimum 95%, Missing); stomach: 59.6708% (minimum 97%, Missing); thymus: 66.8203% (minimum 95%, Missing); thyroid gland: 52.1583% (minimum 95%, Missing); tongue: 52.5362% (minimum 97%, Missing); urinary bladder: 52.1583% (minimum 97%, Missing)",-0.428417,-0.448417,-0.616289,0,5,partial,24.3,13.3,13.3,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 2); thyroid gland: 13.3 nTPM (manageable, limit 5); tongue: 13.1 nTPM (protected, limit 2); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 2); colon: 9.9 nTPM (protected, limit 2); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); stomach: 9.8 nTPM (protected, limit 2); small intestine: 9.5 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 2); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); hippocampal formation: 6.6 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162928,PEX13,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.1814% (minimum 65%, Missing); adrenal gland: 65.0224% (minimum 75%, Missing); amygdala: 66.5138% (minimum 75%, Missing); basal ganglia: 67.4419% (minimum 75%, Missing); bone marrow: 66.5138% (minimum 75%, Missing); cerebellum: 70.7317% (minimum 75%, Missing); cerebral cortex: 68.7204% (minimum 75%, Missing); choroid plexus: 65.9091% (minimum 75%, Missing); colon: 59.4262% (minimum 70%, Missing); duodenum: 59.4262% (minimum 75%, Missing); esophagus: 59.4262% (minimum 70%, Missing); heart muscle: 55.7692% (minimum 75%, Missing); hippocampal formation: 68.7204% (minimum 75%, Missing); hypothalamus: 67.4419% (minimum 75%, Missing); kidney: 52.5362% (minimum 75%, Missing); liver: 37.3711% (minimum 75%, Missing); lung: 61.7021% (minimum 75%, Missing); lymph node: 68.7204% (minimum 70%, Missing); midbrain: 67.7570% (minimum 75%, Missing); pancreas: 55.9846% (minimum 75%, Missing); parathyroid gland: 61.1814% (minimum 70%, Missing); pituitary gland: 66.8203% (minimum 75%, Missing); rectum: 58.4677% (minimum 70%, Missing); retina: 63.0435% (minimum 75%, Missing); salivary gland: 63.3188% (minimum 70%, Missing); skeletal muscle: 50.6993% (minimum 75%, Missing); small intestine: 60.4167% (minimum 75%, Missing); smooth muscle: 65.0224% (minimum 75%, Missing); spinal cord: 65.3153% (minimum 75%, Missing); stomach: 59.6708% (minimum 70%, Missing); thyroid gland: 52.1583% (minimum 65%, Missing); tongue: 52.5362% (minimum 70%, Missing); urinary bladder: 52.1583% (minimum 70%, Missing)",-0.128417,-0.178417,-0.376289,0,5,partial,24.3,13.3,13.3,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 2); thyroid gland: 13.3 nTPM (manageable, limit 5); tongue: 13.1 nTPM (protected, limit 2); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 2); colon: 9.9 nTPM (protected, limit 2); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); stomach: 9.8 nTPM (protected, limit 2); small intestine: 9.5 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 2); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); hippocampal formation: 6.6 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162928,PEX13,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.1814% (minimum 65%, Missing); adrenal gland: 65.0224% (minimum 75%, Missing); amygdala: 66.5138% (minimum 75%, Missing); basal ganglia: 67.4419% (minimum 75%, Missing); bone marrow: 66.5138% (minimum 75%, Missing); cerebellum: 70.7317% (minimum 75%, Missing); cerebral cortex: 68.7204% (minimum 75%, Missing); choroid plexus: 65.9091% (minimum 75%, Missing); colon: 59.4262% (minimum 70%, Missing); duodenum: 59.4262% (minimum 75%, Missing); esophagus: 59.4262% (minimum 70%, Missing); heart muscle: 55.7692% (minimum 75%, Missing); hippocampal formation: 68.7204% (minimum 75%, Missing); hypothalamus: 67.4419% (minimum 75%, Missing); kidney: 52.5362% (minimum 75%, Missing); liver: 37.3711% (minimum 75%, Missing); lung: 61.7021% (minimum 75%, Missing); lymph node: 68.7204% (minimum 70%, Missing); midbrain: 67.7570% (minimum 75%, Missing); pancreas: 55.9846% (minimum 75%, Missing); parathyroid gland: 61.1814% (minimum 70%, Missing); pituitary gland: 66.8203% (minimum 75%, Missing); rectum: 58.4677% (minimum 70%, Missing); retina: 63.0435% (minimum 75%, Missing); salivary gland: 63.3188% (minimum 70%, Missing); skeletal muscle: 50.6993% (minimum 75%, Missing); small intestine: 60.4167% (minimum 75%, Missing); smooth muscle: 65.0224% (minimum 75%, Missing); spinal cord: 65.3153% (minimum 75%, Missing); stomach: 59.6708% (minimum 70%, Missing); thyroid gland: 52.1583% (minimum 65%, Missing); tongue: 52.5362% (minimum 70%, Missing); urinary bladder: 52.1583% (minimum 70%, Missing)",-0.128417,-0.178417,-0.376289,0,5,partial,24.3,13.3,13.3,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 3); thyroid gland: 13.3 nTPM (manageable, limit 5); tongue: 13.1 nTPM (protected, limit 3); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 3); colon: 9.9 nTPM (protected, limit 3); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); stomach: 9.8 nTPM (protected, limit 3); small intestine: 9.5 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); adipose tissue: 9.2 nTPM (manageable, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 3); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); hippocampal formation: 6.6 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162928,PEX13,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.1814% (minimum 65%, Missing); adrenal gland: 65.0224% (minimum 75%, Missing); amygdala: 66.5138% (minimum 75%, Missing); basal ganglia: 67.4419% (minimum 75%, Missing); bone marrow: 66.5138% (minimum 75%, Missing); cerebellum: 70.7317% (minimum 75%, Missing); cerebral cortex: 68.7204% (minimum 75%, Missing); choroid plexus: 65.9091% (minimum 75%, Missing); colon: 59.4262% (minimum 70%, Missing); duodenum: 59.4262% (minimum 75%, Missing); esophagus: 59.4262% (minimum 70%, Missing); heart muscle: 55.7692% (minimum 75%, Missing); hippocampal formation: 68.7204% (minimum 75%, Missing); hypothalamus: 67.4419% (minimum 75%, Missing); kidney: 52.5362% (minimum 75%, Missing); liver: 37.3711% (minimum 75%, Missing); lung: 61.7021% (minimum 75%, Missing); lymph node: 68.7204% (minimum 70%, Missing); midbrain: 67.7570% (minimum 75%, Missing); pancreas: 55.9846% (minimum 75%, Missing); parathyroid gland: 61.1814% (minimum 70%, Missing); pituitary gland: 66.8203% (minimum 75%, Missing); rectum: 58.4677% (minimum 70%, Missing); retina: 63.0435% (minimum 75%, Missing); salivary gland: 63.3188% (minimum 70%, Missing); skeletal muscle: 50.6993% (minimum 75%, Missing); small intestine: 60.4167% (minimum 75%, Missing); smooth muscle: 65.0224% (minimum 75%, Missing); spinal cord: 65.3153% (minimum 75%, Missing); stomach: 59.6708% (minimum 70%, Missing); thyroid gland: 52.1583% (minimum 65%, Missing); tongue: 52.5362% (minimum 70%, Missing); urinary bladder: 52.1583% (minimum 70%, Missing)",-0.128417,-0.178417,-0.376289,0,5,partial,24.3,13.3,13.3,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 3); thyroid gland: 13.3 nTPM (manageable, limit 5); tongue: 13.1 nTPM (protected, limit 3); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 3); colon: 9.9 nTPM (protected, limit 3); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); stomach: 9.8 nTPM (protected, limit 3); small intestine: 9.5 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); adipose tissue: 9.2 nTPM (manageable, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 3); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); hippocampal formation: 6.6 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162928,PEX13,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.1814% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 65.0224% (minimum 75%, Baseline (adaptation disabled)); amygdala: 66.5138% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 67.4419% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.5138% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.7317% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.7204% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 65.9091% (minimum 75%, Baseline (adaptation disabled)); colon: 59.4262% (minimum 70%, Baseline (adaptation disabled)); duodenum: 59.4262% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.4262% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 55.7692% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.7204% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.4419% (minimum 75%, Baseline (adaptation disabled)); kidney: 52.5362% (minimum 75%, Baseline (adaptation disabled)); liver: 37.3711% (minimum 75%, Baseline (adaptation disabled)); lung: 61.7021% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.7204% (minimum 70%, Baseline (adaptation disabled)); midbrain: 67.7570% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.9846% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.1814% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 66.8203% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.4677% (minimum 70%, Baseline (adaptation disabled)); retina: 63.0435% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.3188% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 50.6993% (minimum 75%, Baseline (adaptation disabled)); small intestine: 60.4167% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.0224% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.3153% (minimum 75%, Baseline (adaptation disabled)); stomach: 59.6708% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 52.1583% (minimum 65%, Baseline (adaptation disabled)); tongue: 52.5362% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.1583% (minimum 70%, Baseline (adaptation disabled))",-0.128417,-0.178417,-0.376289,0,5,partial,24.3,13.3,13.3,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 3); thyroid gland: 13.3 nTPM (manageable, limit 5); tongue: 13.1 nTPM (protected, limit 3); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 3); colon: 9.9 nTPM (protected, limit 3); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); stomach: 9.8 nTPM (protected, limit 3); small intestine: 9.5 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); adipose tissue: 9.2 nTPM (manageable, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 3); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); hippocampal formation: 6.6 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162928,PEX13,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.1429% (minimum 99%, Missing); amygdala: 89.2779% (minimum 99%, Missing); basal ganglia: 65.0718% (minimum 99%, Missing); cerebellum: 46.9505% (minimum 99%, Missing); cerebral cortex: 72.9875% (minimum 99%, Missing); choroid plexus: 95.5504% (minimum 99%, Missing); esophagus: 95.5504% (minimum 97%, Missing); heart muscle: 96.0000% (minimum 99%, Missing); hippocampal formation: 83.0957% (minimum 99%, Missing); hypothalamus: 87.7419% (minimum 99%, Missing); kidney: 93.3638% (minimum 99%, Missing); lung: 96.6825% (minimum 99%, Missing); midbrain: 97.3747% (minimum 99%, Missing); pancreas: 98.5507% (minimum 99%, Missing); pituitary gland: 95.1049% (minimum 99%, Missing); salivary gland: 90.0662% (minimum 97%, Missing); small intestine: 97.6077% (minimum 99%, Missing); spinal cord: 96.2264% (minimum 99%, Missing); spleen: 86.6242% (minimum 90%, Approved); thyroid gland: 92.9385% (minimum 95%, Missing); urinary bladder: 96.2264% (minimum 97%, Missing)",-0.033758,-0.0693377,-0.520495,0,5,partial,46.1,4.5,6.3,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162931,TRIM17,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 65.0718% (minimum 75%, Missing); cerebellum: 46.9505% (minimum 75%, Missing); cerebral cortex: 72.9875% (minimum 75%, Missing)",0.266242,0.200662,-0.280495,0,5,partial,46.1,4.5,6.3,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162931,TRIM17,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 65.0718% (minimum 75%, Missing); cerebellum: 46.9505% (minimum 75%, Missing); cerebral cortex: 72.9875% (minimum 75%, Missing)",0.266242,0.200662,-0.280495,0,5,partial,46.1,4.5,6.3,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162931,TRIM17,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 65.0718% (minimum 75%, Missing); cerebellum: 46.9505% (minimum 75%, Missing); cerebral cortex: 72.9875% (minimum 75%, Missing)",0.266242,0.200662,-0.280495,0,5,partial,46.1,4.5,6.3,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162931,TRIM17,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 65.0718% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 46.9505% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.9875% (minimum 75%, Baseline (adaptation disabled))",0.216242,0.200662,-0.280495,0,5,partial,46.1,4.5,6.3,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); spleen: 6.3 nTPM (manageable, limit 5); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162931,TRIM17,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.9048% (minimum 95%, Missing); adrenal gland: 84.3931% (minimum 99%, Missing); amygdala: 90.6832% (minimum 99%, Missing); basal ganglia: 87.9518% (minimum 99%, Missing); bone marrow: 87.4251% (minimum 99%, Missing); cerebellum: 86.3905% (minimum 99%, Missing); cerebral cortex: 85.3801% (minimum 99%, Missing); choroid plexus: 77.6596% (minimum 99%, Missing); colon: 84.3931% (minimum 97%, Missing); duodenum: 87.9518% (minimum 99%, Missing); esophagus: 85.3801% (minimum 97%, Missing); heart muscle: 86.3905% (minimum 99%, Missing); hippocampal formation: 89.0244% (minimum 99%, Missing); hypothalamus: 87.9518% (minimum 99%, Missing); kidney: 80.6630% (minimum 99%, Missing); liver: 90.1235% (minimum 99%, Missing); lung: 85.8824% (minimum 99%, Missing); lymph node: 83.9080% (minimum 97%, Missing); midbrain: 90.6832% (minimum 99%, Missing); pancreas: 85.3801% (minimum 99%, Missing); parathyroid gland: 73.7374% (minimum 97%, Missing); pituitary gland: 71.9212% (minimum 99%, Missing); rectum: 82.9545% (minimum 97%, Missing); retina: 66.0633% (minimum 99%, Missing); salivary gland: 84.3931% (minimum 97%, Missing); skeletal muscle: 89.5706% (minimum 99%, Missing); skin: 74.8718% (minimum 95%, Missing); small intestine: 84.3931% (minimum 99%, Missing); smooth muscle: 81.5642% (minimum 99%, Missing); spinal cord: 88.4848% (minimum 99%, Missing); spleen: 81.1111% (minimum 95%, Missing); stomach: 85.8824% (minimum 97%, Missing); thymus: 78.4946% (minimum 95%, Missing); thyroid gland: 79.3478% (minimum 95%, Missing); tongue: 93.5897% (minimum 97%, Missing); urinary bladder: 83.9080% (minimum 97%, Missing)",-0.201282,-0.232626,-0.329367,0,80,unavailable,7.5,5.2,4.9,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 2); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162994,CLHC1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 71.9212% (minimum 75%, Missing); retina: 66.0633% (minimum 75%, Missing)",0.0987179,0.0373737,-0.0893665,0,80,unavailable,7.5,5.2,4.9,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 2); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162994,CLHC1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 71.9212% (minimum 75%, Missing); retina: 66.0633% (minimum 75%, Missing)",0.0987179,0.0373737,-0.0893665,0,80,unavailable,7.5,5.2,4.9,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 3); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162994,CLHC1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 71.9212% (minimum 75%, Missing); retina: 66.0633% (minimum 75%, Missing)",0.0987179,0.0373737,-0.0893665,0,80,unavailable,7.5,5.2,4.9,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 3); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162994,CLHC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 71.9212% (minimum 75%, Baseline (adaptation disabled)); retina: 66.0633% (minimum 75%, Baseline (adaptation disabled))",0.0987179,0.0373737,-0.0893665,0,80,unavailable,7.5,5.2,4.9,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 3); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162994,CLHC1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.2609% (minimum 90%, Approved); adrenal gland: 72.0000% (minimum 99%, Missing); amygdala: 72.0000% (minimum 99%, Missing); basal ganglia: 64.2857% (minimum 99%, Missing); bone marrow: 92.3077% (minimum 98%, Approved); cerebellum: 92.3077% (minimum 98%, Approved); cerebral cortex: 67.9245% (minimum 99%, Missing); choroid plexus: 90.0000% (minimum 99%, Missing); colon: 72.0000% (minimum 97%, Missing); duodenum: 73.4694% (minimum 99%, Missing); esophagus: 73.4694% (minimum 97%, Missing); heart muscle: 54.5455% (minimum 98%, Approved); hippocampal formation: 67.9245% (minimum 99%, Missing); hypothalamus: 83.7209% (minimum 99%, Missing); kidney: 67.9245% (minimum 99%, Missing); liver: 76.5957% (minimum 99%, Missing); lung: 75.0000% (minimum 98%, Approved); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 83.7209% (minimum 99%, Missing); pancreas: 80.0000% (minimum 99%, Missing); parathyroid gland: 70.5882% (minimum 95%, Approved); pituitary gland: 76.5957% (minimum 99%, Missing); rectum: 78.2609% (minimum 97%, Missing); retina: 76.5957% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 95%, Approved); skeletal muscle: 69.2308% (minimum 98%, Approved); skin: 75.0000% (minimum 90%, Approved); small intestine: 76.5957% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 98%, Approved); spinal cord: 85.7143% (minimum 99%, Missing); spleen: 69.2308% (minimum 90%, Approved); stomach: 48.6486% (minimum 97%, Missing); thymus: 75.0000% (minimum 95%, Missing); thyroid gland: 67.9245% (minimum 90%, Approved); tongue: 69.2308% (minimum 97%, Missing); urinary bladder: 76.5957% (minimum 97%, Missing)",-0.220755,-0.483514,-0.434545,0,2,partial,3,3.8,1.7,"stomach: 3.8 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 2); basal ganglia: 2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162999,DUSP19,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 72.0000% (minimum 75%, Missing); amygdala: 72.0000% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); cerebral cortex: 67.9245% (minimum 75%, Missing); duodenum: 73.4694% (minimum 75%, Missing); heart muscle: 54.5455% (minimum 70%, Approved); hippocampal formation: 67.9245% (minimum 75%, Missing); kidney: 67.9245% (minimum 75%, Missing); skeletal muscle: 69.2308% (minimum 70%, Approved); smooth muscle: 66.6667% (minimum 70%, Approved); stomach: 48.6486% (minimum 70%, Missing); tongue: 69.2308% (minimum 70%, Missing)",0.0792453,-0.213514,-0.154545,0,2,partial,3,3.8,1.7,"stomach: 3.8 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 2); basal ganglia: 2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162999,DUSP19,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 72.0000% (minimum 75%, Missing); amygdala: 72.0000% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); cerebral cortex: 67.9245% (minimum 75%, Missing); duodenum: 73.4694% (minimum 75%, Missing); heart muscle: 54.5455% (minimum 70%, Approved); hippocampal formation: 67.9245% (minimum 75%, Missing); kidney: 67.9245% (minimum 75%, Missing); skeletal muscle: 69.2308% (minimum 70%, Approved); smooth muscle: 66.6667% (minimum 70%, Approved); stomach: 48.6486% (minimum 70%, Missing); tongue: 69.2308% (minimum 70%, Missing)",0.0792453,-0.213514,-0.154545,0,2,partial,3,3.8,1.7,"stomach: 3.8 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 2); basal ganglia: 2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162999,DUSP19,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 72.0000% (minimum 75%, Missing); amygdala: 72.0000% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); cerebral cortex: 67.9245% (minimum 75%, Missing); duodenum: 73.4694% (minimum 75%, Missing); heart muscle: 54.5455% (minimum 70%, Approved); hippocampal formation: 67.9245% (minimum 75%, Missing); kidney: 67.9245% (minimum 75%, Missing); skeletal muscle: 69.2308% (minimum 70%, Approved); smooth muscle: 66.6667% (minimum 70%, Approved); stomach: 48.6486% (minimum 70%, Missing); tongue: 69.2308% (minimum 70%, Missing)",0.0792453,-0.213514,-0.154545,0,2,partial,3,3.8,1.7,"stomach: 3.8 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 2); basal ganglia: 2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162999,DUSP19,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 72.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.2857% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 67.9245% (minimum 75%, Baseline (adaptation disabled)); duodenum: 73.4694% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 54.5455% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.9245% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.9245% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 69.2308% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); stomach: 48.6486% (minimum 70%, Baseline (adaptation disabled)); tongue: 69.2308% (minimum 70%, Baseline (adaptation disabled))",0.0292453,-0.213514,-0.204545,0,2,partial,3,3.8,1.7,"stomach: 3.8 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000162999,DUSP19,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.1739% (minimum 99%, Missing); amygdala: 84.1270% (minimum 99%, Missing); basal ganglia: 86.8852% (minimum 99%, Missing); bone marrow: 75.7143% (minimum 99%, Missing); cerebellum: 84.8000% (minimum 99%, Missing); cerebral cortex: 88.3333% (minimum 99%, Missing); choroid plexus: 93.8053% (minimum 99%, Missing); colon: 85.4839% (minimum 97%, Missing); duodenum: 92.1739% (minimum 99%, Missing); esophagus: 84.1270% (minimum 97%, Missing); heart muscle: 93.8053% (minimum 95%, Enhanced); hippocampal formation: 80.3030% (minimum 99%, Missing); hypothalamus: 85.4839% (minimum 99%, Missing); kidney: 86.8852% (minimum 99%, Missing); liver: 79.6992% (minimum 99%, Missing); lung: 89.0756% (minimum 99%, Missing); lymph node: 71.1409% (minimum 80%, Enhanced); midbrain: 86.8852% (minimum 99%, Missing); pancreas: 86.8852% (minimum 99%, Missing); pituitary gland: 92.9825% (minimum 99%, Missing); rectum: 82.8125% (minimum 97%, Missing); retina: 82.8125% (minimum 99%, Missing); salivary gland: 89.0756% (minimum 97%, Missing); skeletal muscle: 91.3793% (minimum 99%, Missing); skin: 82.1705% (minimum 95%, Missing); small intestine: 86.8852% (minimum 99%, Missing); smooth muscle: 87.6033% (minimum 99%, Missing); spinal cord: 80.9160% (minimum 99%, Missing); stomach: 85.4839% (minimum 97%, Missing); thymus: 63.0952% (minimum 95%, Missing); thyroid gland: 92.9825% (minimum 95%, Missing); tongue: 94.6429% (minimum 97%, Missing); urinary bladder: 87.6033% (minimum 97%, Missing)",-0.319048,-0.141875,-0.232857,0,2,partial,3.4,4.3,6.2,"thymus: 6.2 nTPM (manageable, limit 5); bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163006,CCDC138,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 63.0952% (minimum 65%, Missing)",-0.0190476,0.128125,0.00714286,0,2,partial,3.4,4.3,6.2,"thymus: 6.2 nTPM (manageable, limit 5); bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163006,CCDC138,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 63.0952% (minimum 65%, Missing)",-0.0190476,0.128125,0.00714286,0,2,partial,3.4,4.3,6.2,"thymus: 6.2 nTPM (manageable, limit 5); bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163006,CCDC138,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 63.0952% (minimum 65%, Missing)",-0.0190476,0.128125,0.00714286,0,2,partial,3.4,4.3,6.2,"thymus: 6.2 nTPM (manageable, limit 5); bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163006,CCDC138,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 63.0952% (minimum 65%, Baseline (adaptation disabled))",-0.0190476,0.0114094,0.00714286,0,2,partial,3.4,4.3,6.2,"thymus: 6.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163006,CCDC138,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.9011% (minimum 99%, Missing); hypothalamus: 97.8261% (minimum 99%, Missing); pituitary gland: 93.7500% (minimum 99%, Missing)",0.05,0.03,-0.0525,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163012,ZSWIM2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163012,ZSWIM2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163012,ZSWIM2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163012,ZSWIM2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163012,ZSWIM2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.0370% (minimum 99%, Missing); basal ganglia: 96.3235% (minimum 99%, Missing); choroid plexus: 98.4962% (minimum 99%, Missing); hippocampal formation: 95.6204% (minimum 99%, Missing); hypothalamus: 95.6204% (minimum 99%, Missing); spinal cord: 98.4962% (minimum 99%, Missing)",0.05,0.03,-0.0337956,0,9,partial,0.6,0,0,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163060,TEKT4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.206204,0,9,partial,0.6,0,0,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163060,TEKT4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.206204,0,9,partial,0.6,0,0,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163060,TEKT4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.206204,0,9,partial,0.6,0,0,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163060,TEKT4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.206204,0,9,partial,0.6,0,0,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163060,TEKT4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163114,PDHA2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163114,PDHA2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163114,PDHA2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163114,PDHA2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163114,PDHA2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.00945032,0,2,partial,1.2,0.1,0.2,,,54,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163206,SMCP,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.24945,0,2,partial,1.2,0.1,0.2,,,54,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163206,SMCP,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.24945,0,2,partial,1.2,0.1,0.2,,,54,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163206,SMCP,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.24945,0,2,partial,1.2,0.1,0.2,,,54,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163206,SMCP,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349725,0.299863,0.248353,0,2,partial,1.2,0.1,0.2,"cerebellum: 1.2 nTPM (vital, limit 1)",,54,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163206,SMCP,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.4877% (minimum 95%, Missing); adrenal gland: 92.6370% (minimum 99%, Missing); amygdala: 97.3022% (minimum 99%, Missing); basal ganglia: 96.9534% (minimum 99%, Missing); cerebral cortex: 97.6534% (minimum 99%, Missing); choroid plexus: 97.1275% (minimum 99%, Missing); colon: 95.2465% (minimum 97%, Missing); duodenum: 98.7226% (minimum 99%, Missing); esophagus: 95.7522% (minimum 97%, Missing); heart muscle: 87.9675% (minimum 99%, Missing); hippocampal formation: 97.6534% (minimum 99%, Missing); hypothalamus: 98.1851% (minimum 99%, Missing); kidney: 94.0870% (minimum 99%, Missing); liver: 92.4786% (minimum 99%, Missing); lung: 87.3990% (minimum 99%, Missing); midbrain: 97.1275% (minimum 99%, Missing); pancreas: 98.3636% (minimum 99%, Missing); pituitary gland: 95.5830% (minimum 99%, Missing); salivary gland: 96.7800% (minimum 97%, Missing); skeletal muscle: 96.7800% (minimum 99%, Missing); small intestine: 94.0870% (minimum 99%, Missing); smooth muscle: 96.9534% (minimum 99%, Missing); spinal cord: 98.3636% (minimum 99%, Missing); spleen: 86.1465% (minimum 95%, Missing); stomach: 96.7800% (minimum 97%, Missing); thyroid gland: 83.4877% (minimum 95%, Missing); urinary bladder: 93.5986% (minimum 97%, Missing)",-0.115123,-0.0340138,-0.11601,0,80,unavailable,7.8,3.7,10.7,"adipose tissue: 10.7 nTPM (manageable, limit 5); thyroid gland: 10.7 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); small intestine: 3.4 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163239,TDRD10,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.184877,0.235986,0.12399,0,80,unavailable,7.8,3.7,10.7,"adipose tissue: 10.7 nTPM (manageable, limit 5); thyroid gland: 10.7 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); small intestine: 3.4 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163239,TDRD10,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.184877,0.235986,0.12399,0,80,unavailable,7.8,3.7,10.7,"adipose tissue: 10.7 nTPM (manageable, limit 5); thyroid gland: 10.7 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); kidney: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163239,TDRD10,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.184877,0.235986,0.12399,0,80,unavailable,7.8,3.7,10.7,"adipose tissue: 10.7 nTPM (manageable, limit 5); thyroid gland: 10.7 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); kidney: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163239,TDRD10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.184877,0.235986,0.12399,0,80,unavailable,7.8,3.7,10.7,"adipose tissue: 10.7 nTPM (manageable, limit 5); thyroid gland: 10.7 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); kidney: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163239,TDRD10,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 94.1176% (minimum 99%, Missing)",0.05,0.03,-0.0488235,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: High (Supported),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163254,CRYGC,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.191176,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: High (Supported),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163254,CRYGC,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.191176,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: High (Supported),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163254,CRYGC,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.191176,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: High (Supported),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163254,CRYGC,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.191176,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: High (Supported),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163254,CRYGC,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.9933% (minimum 99%, Missing); basal ganglia: 98.0066% (minimum 99%, Missing); bone marrow: 98.3333% (minimum 99%, Missing); choroid plexus: 94.5513% (minimum 99%, Missing); hippocampal formation: 98.0066% (minimum 99%, Missing); hypothalamus: 97.0395% (minimum 99%, Missing); liver: 98.9933% (minimum 99%, Missing); lung: 94.5513% (minimum 99%, Missing); retina: 98.0066% (minimum 99%, Missing)",0.0466216,0.0166221,-0.0444872,0,80,unavailable,1.7,0.4,0.1,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163263,CFAP141,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346622,0.286622,0.195513,0,80,unavailable,1.7,0.4,0.1,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163263,CFAP141,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346622,0.286622,0.195513,0,80,unavailable,1.7,0.4,0.1,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163263,CFAP141,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346622,0.286622,0.195513,0,80,unavailable,1.7,0.4,0.1,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163263,CFAP141,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346622,0.286622,0.195513,0,80,unavailable,1.7,0.4,0.1,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163263,CFAP141,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"lung: 89.8396% (minimum 95%, Enhanced)",0.05,0.03,-0.0516043,0,12,partial,3.8,0,0.1,,colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163283,ALPP,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,12,partial,3.8,0,0.1,,colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163283,ALPP,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,12,partial,3.8,0,0.1,,colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163283,ALPP,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,12,partial,3.8,0,0.1,,colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163283,ALPP,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347033,0.3,0.148396,0,12,partial,3.8,0,0.1,"lung: 3.8 nTPM (vital, limit 1)",colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163283,ALPP,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"colon: 90.0000% (minimum 97%, Missing); lung: 69.2308% (minimum 98%, Approved); rectum: 90.0000% (minimum 97%, Missing); thymus: 90.0000% (minimum 95%, Missing)",-0.05,-0.07,-0.287692,0,11,partial,0.4,0.1,0.1,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); skin 1 / fibrohistiocytic cells: Low (Approved); small intestine / enterocytes - Microvilli: High (Approved),92,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / fibrohistiocytic cells; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163286,ALPG,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"lung: 69.2308% (minimum 70%, Approved)",0.25,0.2,-0.00769231,0,11,partial,0.4,0.1,0.1,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); skin 1 / fibrohistiocytic cells: Low (Approved); small intestine / enterocytes - Microvilli: High (Approved),92,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / fibrohistiocytic cells; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163286,ALPG,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"lung: 69.2308% (minimum 70%, Approved)",0.25,0.2,-0.00769231,0,11,partial,0.4,0.1,0.1,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); skin 1 / fibrohistiocytic cells: Low (Approved); small intestine / enterocytes - Microvilli: High (Approved),92,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / fibrohistiocytic cells; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163286,ALPG,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"lung: 69.2308% (minimum 70%, Approved)",0.25,0.2,-0.00769231,0,11,partial,0.4,0.1,0.1,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); skin 1 / fibrohistiocytic cells: Low (Approved); small intestine / enterocytes - Microvilli: High (Approved),92,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / fibrohistiocytic cells; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163286,ALPG,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"lung: 69.2308% (minimum 75%, Baseline (adaptation disabled))",0.25,0.2,-0.0576923,0,11,partial,0.4,0.1,0.1,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); skin 1 / fibrohistiocytic cells: Low (Approved); small intestine / enterocytes - Microvilli: High (Approved),92,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / fibrohistiocytic cells; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163286,ALPG,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5042% (minimum 95%, Missing); adrenal gland: 45.0000% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 77.4194% (minimum 99%, Missing); bone marrow: 61.5385% (minimum 99%, Missing); cerebellum: 68.5714% (minimum 99%, Missing); cerebral cortex: 75.7895% (minimum 99%, Missing); choroid plexus: 56.6929% (minimum 99%, Missing); colon: 65.4545% (minimum 97%, Missing); duodenum: 69.9029% (minimum 99%, Missing); esophagus: 68.5714% (minimum 97%, Missing); heart muscle: 59.5041% (minimum 99%, Missing); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 78.2609% (minimum 99%, Missing); kidney: 58.0645% (minimum 99%, Missing); liver: 57.6000% (minimum 99%, Missing); lung: 65.4545% (minimum 99%, Missing); lymph node: 44.1718% (minimum 97%, Missing); midbrain: 78.2609% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 57.1429% (minimum 95%, Approved); pituitary gland: 62.6087% (minimum 99%, Missing); rectum: 65.4545% (minimum 97%, Missing); retina: 57.6000% (minimum 99%, Missing); salivary gland: 61.5385% (minimum 97%, Missing); skeletal muscle: 51.0638% (minimum 99%, Missing); skin: 65.4545% (minimum 95%, Missing); small intestine: 62.6087% (minimum 99%, Missing); smooth muscle: 63.1579% (minimum 99%, Missing); spinal cord: 75.7895% (minimum 99%, Missing); spleen: 54.1353% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Missing); thymus: 48.0000% (minimum 95%, Missing); thyroid gland: 56.2500% (minimum 95%, Missing); tongue: 48.0000% (minimum 97%, Missing); urinary bladder: 63.1579% (minimum 97%, Missing)",-0.47,-0.528282,-0.54,0,3,partial,8.8,9.1,7.8,"lymph node: 9.1 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 2); thymus: 7.8 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); thyroid gland: 5.6 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 4); retina: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); pancreas: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163312,HELQ,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5042% (minimum 65%, Missing); adrenal gland: 45.0000% (minimum 75%, Missing); bone marrow: 61.5385% (minimum 75%, Missing); cerebellum: 68.5714% (minimum 75%, Missing); choroid plexus: 56.6929% (minimum 75%, Missing); colon: 65.4545% (minimum 70%, Missing); duodenum: 69.9029% (minimum 75%, Missing); esophagus: 68.5714% (minimum 70%, Missing); heart muscle: 59.5041% (minimum 75%, Missing); kidney: 58.0645% (minimum 75%, Missing); liver: 57.6000% (minimum 75%, Missing); lung: 65.4545% (minimum 75%, Missing); lymph node: 44.1718% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 57.1429% (minimum 65%, Approved); pituitary gland: 62.6087% (minimum 75%, Missing); rectum: 65.4545% (minimum 70%, Missing); retina: 57.6000% (minimum 75%, Missing); salivary gland: 61.5385% (minimum 70%, Missing); skeletal muscle: 51.0638% (minimum 75%, Missing); small intestine: 62.6087% (minimum 75%, Missing); smooth muscle: 63.1579% (minimum 75%, Missing); spleen: 54.1353% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing); thymus: 48.0000% (minimum 65%, Missing); thyroid gland: 56.2500% (minimum 65%, Missing); tongue: 48.0000% (minimum 70%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.17,-0.258282,-0.3,0,3,partial,8.8,9.1,7.8,"lymph node: 9.1 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 2); thymus: 7.8 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); thyroid gland: 5.6 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 4); retina: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); pancreas: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163312,HELQ,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5042% (minimum 65%, Missing); adrenal gland: 45.0000% (minimum 75%, Missing); bone marrow: 61.5385% (minimum 75%, Missing); cerebellum: 68.5714% (minimum 75%, Missing); choroid plexus: 56.6929% (minimum 75%, Missing); colon: 65.4545% (minimum 70%, Missing); duodenum: 69.9029% (minimum 75%, Missing); esophagus: 68.5714% (minimum 70%, Missing); heart muscle: 59.5041% (minimum 75%, Missing); kidney: 58.0645% (minimum 75%, Missing); liver: 57.6000% (minimum 75%, Missing); lung: 65.4545% (minimum 75%, Missing); lymph node: 44.1718% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 57.1429% (minimum 65%, Approved); pituitary gland: 62.6087% (minimum 75%, Missing); rectum: 65.4545% (minimum 70%, Missing); retina: 57.6000% (minimum 75%, Missing); salivary gland: 61.5385% (minimum 70%, Missing); skeletal muscle: 51.0638% (minimum 75%, Missing); small intestine: 62.6087% (minimum 75%, Missing); smooth muscle: 63.1579% (minimum 75%, Missing); spleen: 54.1353% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing); thymus: 48.0000% (minimum 65%, Missing); thyroid gland: 56.2500% (minimum 65%, Missing); tongue: 48.0000% (minimum 70%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.17,-0.258282,-0.3,0,3,partial,8.8,9.1,7.8,"lymph node: 9.1 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 3); thymus: 7.8 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); thyroid gland: 5.6 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 4); retina: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); rectum: 3.8 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); pancreas: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163312,HELQ,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5042% (minimum 65%, Missing); adrenal gland: 45.0000% (minimum 75%, Missing); bone marrow: 61.5385% (minimum 75%, Missing); cerebellum: 68.5714% (minimum 75%, Missing); choroid plexus: 56.6929% (minimum 75%, Missing); colon: 65.4545% (minimum 70%, Missing); duodenum: 69.9029% (minimum 75%, Missing); esophagus: 68.5714% (minimum 70%, Missing); heart muscle: 59.5041% (minimum 75%, Missing); kidney: 58.0645% (minimum 75%, Missing); liver: 57.6000% (minimum 75%, Missing); lung: 65.4545% (minimum 75%, Missing); lymph node: 44.1718% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 57.1429% (minimum 65%, Approved); pituitary gland: 62.6087% (minimum 75%, Missing); rectum: 65.4545% (minimum 70%, Missing); retina: 57.6000% (minimum 75%, Missing); salivary gland: 61.5385% (minimum 70%, Missing); skeletal muscle: 51.0638% (minimum 75%, Missing); small intestine: 62.6087% (minimum 75%, Missing); smooth muscle: 63.1579% (minimum 75%, Missing); spleen: 54.1353% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing); thymus: 48.0000% (minimum 65%, Missing); thyroid gland: 56.2500% (minimum 65%, Missing); tongue: 48.0000% (minimum 70%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.17,-0.258282,-0.3,0,3,partial,8.8,9.1,7.8,"lymph node: 9.1 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 3); thymus: 7.8 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); thyroid gland: 5.6 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 4); retina: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); rectum: 3.8 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); pancreas: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163312,HELQ,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5042% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 45.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.5385% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.5714% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 56.6929% (minimum 75%, Baseline (adaptation disabled)); colon: 65.4545% (minimum 70%, Baseline (adaptation disabled)); duodenum: 69.9029% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.5714% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.5041% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.0645% (minimum 75%, Baseline (adaptation disabled)); liver: 57.6000% (minimum 75%, Baseline (adaptation disabled)); lung: 65.4545% (minimum 75%, Baseline (adaptation disabled)); lymph node: 44.1718% (minimum 70%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.1429% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.6087% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.4545% (minimum 70%, Baseline (adaptation disabled)); retina: 57.6000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.5385% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 51.0638% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.6087% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.1579% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.1353% (minimum 65%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.2500% (minimum 65%, Baseline (adaptation disabled)); tongue: 48.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.1579% (minimum 70%, Baseline (adaptation disabled))",-0.17,-0.258282,-0.3,0,3,partial,8.8,9.1,7.8,"lymph node: 9.1 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 3); thymus: 7.8 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); thyroid gland: 5.6 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 3); retina: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); rectum: 3.8 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); pancreas: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163312,HELQ,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Uncertain); adrenal gland: 73.4266% (minimum 99%, Missing); amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 91.3043% (minimum 99%, Missing); bone marrow: 58.0110% (minimum 99%, Uncertain); cerebellum: 92.9204% (minimum 99%, Uncertain); cerebral cortex: 84.6774% (minimum 99%, Uncertain); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 77.2059% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Uncertain); esophagus: 67.7419% (minimum 97%, Uncertain); heart muscle: 74.4681% (minimum 99%, Uncertain); hippocampal formation: 91.3043% (minimum 99%, Missing); hypothalamus: 90.5172% (minimum 99%, Missing); kidney: 72.9167% (minimum 99%, Uncertain); liver: 83.3333% (minimum 99%, Uncertain); lung: 74.4681% (minimum 99%, Uncertain); lymph node: 57.3770% (minimum 97%, Uncertain); midbrain: 90.5172% (minimum 99%, Missing); pancreas: 76.0870% (minimum 99%, Uncertain); parathyroid gland: 83.3333% (minimum 97%, Uncertain); pituitary gland: 90.5172% (minimum 99%, Missing); rectum: 79.5455% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); salivary gland: 76.0870% (minimum 97%, Uncertain); skeletal muscle: 62.8743% (minimum 99%, Uncertain); skin: 66.0377% (minimum 95%, Uncertain); small intestine: 77.7778% (minimum 99%, Missing); smooth muscle: 78.9474% (minimum 99%, Uncertain); spinal cord: 88.2353% (minimum 99%, Missing); spleen: 72.4138% (minimum 95%, Uncertain); stomach: 75.0000% (minimum 97%, Missing); thymus: 69.0789% (minimum 95%, Missing); thyroid gland: 59.3220% (minimum 95%, Uncertain); tongue: 84.6774% (minimum 97%, Missing); urinary bladder: 73.9437% (minimum 97%, Uncertain)",-0.35678,-0.39623,-0.40989,0,3,partial,7.6,7.8,7.2,"lymph node: 7.8 nTPM (protected, limit 2); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); esophagus: 5 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163322,ABRAXAS1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.4266% (minimum 75%, Missing); bone marrow: 58.0110% (minimum 75%, Uncertain); esophagus: 67.7419% (minimum 70%, Uncertain); heart muscle: 74.4681% (minimum 75%, Uncertain); kidney: 72.9167% (minimum 75%, Uncertain); lung: 74.4681% (minimum 75%, Uncertain); lymph node: 57.3770% (minimum 70%, Uncertain); skeletal muscle: 62.8743% (minimum 75%, Uncertain); thyroid gland: 59.3220% (minimum 65%, Uncertain)",-0.0567797,-0.12623,-0.16989,0,3,partial,7.6,7.8,7.2,"lymph node: 7.8 nTPM (protected, limit 2); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); esophagus: 5 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163322,ABRAXAS1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.4266% (minimum 75%, Missing); bone marrow: 58.0110% (minimum 75%, Uncertain); esophagus: 67.7419% (minimum 70%, Uncertain); heart muscle: 74.4681% (minimum 75%, Uncertain); kidney: 72.9167% (minimum 75%, Uncertain); lung: 74.4681% (minimum 75%, Uncertain); lymph node: 57.3770% (minimum 70%, Uncertain); skeletal muscle: 62.8743% (minimum 75%, Uncertain); thyroid gland: 59.3220% (minimum 65%, Uncertain)",-0.0567797,-0.12623,-0.16989,0,3,partial,7.6,7.8,7.2,"lymph node: 7.8 nTPM (protected, limit 3); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); esophagus: 5 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163322,ABRAXAS1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.4266% (minimum 75%, Missing); bone marrow: 58.0110% (minimum 75%, Uncertain); esophagus: 67.7419% (minimum 70%, Uncertain); heart muscle: 74.4681% (minimum 75%, Uncertain); kidney: 72.9167% (minimum 75%, Uncertain); lung: 74.4681% (minimum 75%, Uncertain); lymph node: 57.3770% (minimum 70%, Uncertain); skeletal muscle: 62.8743% (minimum 75%, Uncertain); thyroid gland: 59.3220% (minimum 65%, Uncertain)",-0.0567797,-0.12623,-0.16989,0,3,partial,7.6,7.8,7.2,"lymph node: 7.8 nTPM (protected, limit 3); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); esophagus: 5 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163322,ABRAXAS1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.4266% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 58.0110% (minimum 75%, Baseline (adaptation disabled)); esophagus: 67.7419% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 74.4681% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.9167% (minimum 75%, Baseline (adaptation disabled)); lung: 74.4681% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.3770% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 62.8743% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 59.3220% (minimum 65%, Baseline (adaptation disabled))",-0.0567797,-0.12623,-0.16989,0,3,partial,7.6,7.8,7.2,"lymph node: 7.8 nTPM (protected, limit 3); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); esophagus: 5 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163322,ABRAXAS1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4848% (minimum 99%, Missing); duodenum: 89.0411% (minimum 99%, Missing); retina: 72.2222% (minimum 99%, Missing); salivary gland: 95.5882% (minimum 97%, Missing); skin: 68.4211% (minimum 95%, Missing); small intestine: 89.0411% (minimum 99%, Missing)",-0.265789,-0.0141176,-0.267778,0,80,unavailable,2.5,0.3,3,"retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163357,DCST1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.2222% (minimum 75%, Missing)",0.0342105,0.255882,-0.0277778,0,80,unavailable,2.5,0.3,3,"retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163357,DCST1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.2222% (minimum 75%, Missing)",0.0342105,0.255882,-0.0277778,0,80,unavailable,2.5,0.3,3,"retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163357,DCST1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.2222% (minimum 75%, Missing)",0.0342105,0.255882,-0.0277778,0,80,unavailable,2.5,0.3,3,"retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163357,DCST1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.2222% (minimum 75%, Baseline (adaptation disabled))",0.0342105,0.255882,-0.0277778,0,80,unavailable,2.5,0.3,3,"retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163357,DCST1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 84.4444% (minimum 90%, Approved); adrenal gland: 87.3563% (minimum 99%, Missing); amygdala: 92.6829% (minimum 99%, Missing); basal ganglia: 87.3563% (minimum 99%, Missing); bone marrow: 35.6808% (minimum 99%, Missing); cerebellum: 86.3636% (minimum 99%, Missing); cerebral cortex: 80.0000% (minimum 98%, Approved); choroid plexus: 86.3636% (minimum 99%, Missing); colon: 76.7677% (minimum 97%, Missing); duodenum: 81.7204% (minimum 99%, Missing); esophagus: 85.3933% (minimum 95%, Approved); heart muscle: 67.2566% (minimum 99%, Missing); hippocampal formation: 91.5663% (minimum 99%, Missing); hypothalamus: 90.4762% (minimum 99%, Missing); kidney: 92.6829% (minimum 99%, Missing); liver: 85.3933% (minimum 98%, Approved); lung: 78.3505% (minimum 99%, Missing); lymph node: 27.6364% (minimum 97%, Missing); midbrain: 91.5663% (minimum 99%, Missing); pancreas: 89.4118% (minimum 98%, Approved); parathyroid gland: 96.2025% (minimum 97%, Missing); pituitary gland: 93.8272% (minimum 99%, Missing); rectum: 80.0000% (minimum 97%, Missing); retina: 86.3636% (minimum 99%, Missing); salivary gland: 90.4762% (minimum 97%, Missing); skeletal muscle: 83.5165% (minimum 98%, Approved); skin: 93.8272% (minimum 95%, Missing); small intestine: 73.7864% (minimum 99%, Missing); smooth muscle: 87.3563% (minimum 98%, Approved); spinal cord: 91.5663% (minimum 99%, Missing); spleen: 57.5758% (minimum 95%, Missing); stomach: 78.3505% (minimum 97%, Missing); thymus: 68.4685% (minimum 95%, Missing); thyroid gland: 90.4762% (minimum 95%, Missing); tongue: 78.3505% (minimum 97%, Missing); urinary bladder: 80.8511% (minimum 95%, Approved)",-0.374242,-0.693636,-0.633192,0,0,routine_complete,13.7,19.9,5.6,"lymph node: 19.9 nTPM (protected, limit 2); bone marrow: 13.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163376,KBTBD8,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.6808% (minimum 75%, Missing); heart muscle: 67.2566% (minimum 75%, Missing); lymph node: 27.6364% (minimum 70%, Missing); small intestine: 73.7864% (minimum 75%, Missing); spleen: 57.5758% (minimum 65%, Missing)",-0.0742424,-0.423636,-0.393192,0,0,routine_complete,13.7,19.9,5.6,"lymph node: 19.9 nTPM (protected, limit 2); bone marrow: 13.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163376,KBTBD8,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.6808% (minimum 75%, Missing); heart muscle: 67.2566% (minimum 75%, Missing); lymph node: 27.6364% (minimum 70%, Missing); small intestine: 73.7864% (minimum 75%, Missing); spleen: 57.5758% (minimum 65%, Missing)",-0.0742424,-0.423636,-0.393192,0,0,routine_complete,13.7,19.9,5.6,"lymph node: 19.9 nTPM (protected, limit 3); bone marrow: 13.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163376,KBTBD8,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.6808% (minimum 75%, Missing); heart muscle: 67.2566% (minimum 75%, Missing); lymph node: 27.6364% (minimum 70%, Missing); small intestine: 73.7864% (minimum 75%, Missing); spleen: 57.5758% (minimum 65%, Missing)",-0.0742424,-0.423636,-0.393192,0,0,routine_complete,13.7,19.9,5.6,"lymph node: 19.9 nTPM (protected, limit 3); bone marrow: 13.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163376,KBTBD8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.6808% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 67.2566% (minimum 75%, Baseline (adaptation disabled)); lymph node: 27.6364% (minimum 70%, Baseline (adaptation disabled)); small intestine: 73.7864% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.5758% (minimum 65%, Baseline (adaptation disabled))",-0.0742424,-0.423636,-0.393192,0,0,routine_complete,13.7,19.9,5.6,"lymph node: 19.9 nTPM (protected, limit 3); bone marrow: 13.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163376,KBTBD8,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3260% (minimum 90%, Approved); amygdala: 95.6897% (minimum 99%, Missing); basal ganglia: 94.0678% (minimum 99%, Missing); bone marrow: 14.8396% (minimum 98%, Approved); cerebral cortex: 96.5217% (minimum 98%, Approved); choroid plexus: 93.2773% (minimum 99%, Missing); duodenum: 97.3684% (minimum 98%, Approved); heart muscle: 91.7355% (minimum 98%, Approved); hippocampal formation: 95.6897% (minimum 99%, Missing); hypothalamus: 94.0678% (minimum 99%, Missing); kidney: 94.8718% (minimum 98%, Approved); liver: 82.2222% (minimum 98%, Approved); lung: 46.6387% (minimum 98%, Approved); midbrain: 94.0678% (minimum 99%, Missing); pancreas: 90.9836% (minimum 99%, Missing); pituitary gland: 96.5217% (minimum 99%, Missing); skeletal muscle: 95.6897% (minimum 98%, Approved); small intestine: 95.6897% (minimum 98%, Approved); smooth muscle: 88.8000% (minimum 98%, Approved); spinal cord: 96.5217% (minimum 99%, Missing); spleen: 33.6364% (minimum 90%, Approved); stomach: 94.8718% (minimum 95%, Approved); thymus: 91.7355% (minimum 95%, Missing); tongue: 73.0263% (minimum 97%, Missing); urinary bladder: 65.6805% (minimum 95%, Approved)",-0.563636,-0.293195,-0.831604,0,3,partial,63.7,5.8,21.9,"bone marrow: 63.7 nTPM (vital, limit 2); spleen: 21.9 nTPM (manageable, limit 10); lung: 12.7 nTPM (vital, limit 2); urinary bladder: 5.8 nTPM (protected, limit 4); tongue: 4.1 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163421,PROK2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 14.8396% (minimum 70%, Approved); lung: 46.6387% (minimum 70%, Approved); spleen: 33.6364% (minimum 60%, Approved)",-0.263636,0.00680473,-0.551604,0,3,partial,63.7,5.8,21.9,"bone marrow: 63.7 nTPM (vital, limit 2); spleen: 21.9 nTPM (manageable, limit 10); lung: 12.7 nTPM (vital, limit 2); urinary bladder: 5.8 nTPM (protected, limit 4); tongue: 4.1 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163421,PROK2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 14.8396% (minimum 70%, Approved); lung: 46.6387% (minimum 70%, Approved); spleen: 33.6364% (minimum 60%, Approved)",-0.263636,0.00680473,-0.551604,0,3,partial,63.7,5.8,21.9,"bone marrow: 63.7 nTPM (vital, limit 2); spleen: 21.9 nTPM (manageable, limit 10); lung: 12.7 nTPM (vital, limit 2); urinary bladder: 5.8 nTPM (protected, limit 4); tongue: 4.1 nTPM (protected, limit 3); liver: 2.4 nTPM (vital, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163421,PROK2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 14.8396% (minimum 70%, Approved); lung: 46.6387% (minimum 70%, Approved); spleen: 33.6364% (minimum 60%, Approved)",-0.263636,0.00680473,-0.551604,0,3,partial,63.7,5.8,21.9,"bone marrow: 63.7 nTPM (vital, limit 2); spleen: 21.9 nTPM (manageable, limit 10); lung: 12.7 nTPM (vital, limit 2); urinary bladder: 5.8 nTPM (protected, limit 4); tongue: 4.1 nTPM (protected, limit 3); liver: 2.4 nTPM (vital, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163421,PROK2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3260% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 14.8396% (minimum 75%, Baseline (adaptation disabled)); lung: 46.6387% (minimum 75%, Baseline (adaptation disabled)); spleen: 33.6364% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 65.6805% (minimum 70%, Baseline (adaptation disabled))",-0.313636,-0.0431953,-0.601604,0,3,partial,63.7,5.8,21.9,"bone marrow: 63.7 nTPM (vital, limit 1); spleen: 21.9 nTPM (manageable, limit 5); lung: 12.7 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); urinary bladder: 5.8 nTPM (protected, limit 3); tongue: 4.1 nTPM (protected, limit 3); liver: 2.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163421,PROK2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.01,0,2,partial,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163424,TEX55,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163424,TEX55,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163424,TEX55,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163424,TEX55,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.248088,0,2,partial,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163424,TEX55,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00842271,0,1,partial,0.1,0.3,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163440,PDCL2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248423,0,1,partial,0.1,0.3,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163440,PDCL2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248423,0,1,partial,0.1,0.3,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163440,PDCL2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248423,0,1,partial,0.1,0.3,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163440,PDCL2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34685,0.295283,0.248423,0,1,partial,0.1,0.3,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163440,PDCL2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0488891,0.0288891,0.00755935,0,80,unavailable,2.2,1,1,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163467,TSACC,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348889,0.298889,0.247559,0,80,unavailable,2.2,1,1,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163467,TSACC,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348889,0.298889,0.247559,0,80,unavailable,2.2,1,1,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163467,TSACC,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348889,0.298889,0.247559,0,80,unavailable,2.2,1,1,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163467,TSACC,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348889,0.298889,0.247559,0,80,unavailable,2.2,1,1,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163467,TSACC,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.8101% (minimum 99%, Missing); basal ganglia: 91.7112% (minimum 99%, Missing); cerebellum: 98.8473% (minimum 99%, Missing); cerebral cortex: 94.4904% (minimum 99%, Missing); choroid plexus: 92.7027% (minimum 99%, Missing); colon: 94.7514% (minimum 97%, Missing); duodenum: 95.0139% (minimum 99%, Missing); esophagus: 96.3483% (minimum 97%, Missing); heart muscle: 91.7112% (minimum 99%, Missing); hippocampal formation: 92.9539% (minimum 99%, Missing); hypothalamus: 92.2043% (minimum 99%, Missing); kidney: 95.5432% (minimum 99%, Missing); liver: 94.7514% (minimum 99%, Missing); lung: 93.9726% (minimum 99%, Missing); midbrain: 98.5632% (minimum 99%, Missing); pancreas: 98.5632% (minimum 99%, Missing); pituitary gland: 91.2234% (minimum 99%, Missing); retina: 88.1748% (minimum 99%, Missing); skeletal muscle: 78.4897% (minimum 99%, Missing); small intestine: 97.7208% (minimum 99%, Missing); spinal cord: 98.5632% (minimum 99%, Missing); tongue: 70.8678% (minimum 97%, Missing); urinary bladder: 96.8927% (minimum 97%, Missing)",0.0356322,-0.261322,-0.205103,0,80,unavailable,9.4,14.1,0.5,"tongue: 14.1 nTPM (protected, limit 2); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163491,NEK10,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335632,0.00867769,0.034897,0,80,unavailable,9.4,14.1,0.5,"tongue: 14.1 nTPM (protected, limit 2); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163491,NEK10,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335632,0.00867769,0.034897,0,80,unavailable,9.4,14.1,0.5,"tongue: 14.1 nTPM (protected, limit 3); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163491,NEK10,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335632,0.00867769,0.034897,0,80,unavailable,9.4,14.1,0.5,"tongue: 14.1 nTPM (protected, limit 3); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163491,NEK10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335632,0.00867769,0.034897,0,80,unavailable,9.4,14.1,0.5,"tongue: 14.1 nTPM (protected, limit 3); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163491,NEK10,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 77.4194% (minimum 99%, Missing); amygdala: 88.8889% (minimum 99%, Missing); basal ganglia: 80.0000% (minimum 99%, Missing); bone marrow: 38.0952% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); cerebral cortex: 68.5714% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 68.5714% (minimum 97%, Missing); duodenum: 70.5882% (minimum 99%, Missing); esophagus: 68.5714% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 85.7143% (minimum 99%, Missing); hypothalamus: 85.7143% (minimum 99%, Missing); kidney: 77.4194% (minimum 99%, Missing); liver: 88.8889% (minimum 99%, Missing); lung: 72.7273% (minimum 99%, Missing); lymph node: 39.3443% (minimum 97%, Missing); midbrain: 92.3077% (minimum 99%, Missing); pancreas: 88.8889% (minimum 99%, Missing); parathyroid gland: 85.7143% (minimum 97%, Missing); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 60.0000% (minimum 97%, Missing); retina: 63.1579% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); skeletal muscle: 88.8889% (minimum 99%, Missing); skin: 70.5882% (minimum 95%, Missing); small intestine: 68.5714% (minimum 99%, Missing); smooth muscle: 72.7273% (minimum 99%, Missing); spinal cord: 88.8889% (minimum 99%, Missing); spleen: 64.8649% (minimum 90%, Approved); stomach: 77.4194% (minimum 97%, Missing); thymus: 42.8571% (minimum 95%, Missing); thyroid gland: 72.7273% (minimum 95%, Missing); tongue: 85.7143% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.521429,-0.576557,-0.609048,0,4,partial,3.9,3.7,3.2,"bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163507,CIP2A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 38.0952% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); cerebral cortex: 68.5714% (minimum 75%, Missing); colon: 68.5714% (minimum 70%, Missing); duodenum: 70.5882% (minimum 75%, Missing); esophagus: 68.5714% (minimum 70%, Missing); lung: 72.7273% (minimum 75%, Missing); lymph node: 39.3443% (minimum 70%, Missing); rectum: 60.0000% (minimum 70%, Missing); retina: 63.1579% (minimum 75%, Missing); small intestine: 68.5714% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); thymus: 42.8571% (minimum 65%, Missing)",-0.221429,-0.306557,-0.369048,0,4,partial,3.9,3.7,3.2,"bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163507,CIP2A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 38.0952% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); cerebral cortex: 68.5714% (minimum 75%, Missing); colon: 68.5714% (minimum 70%, Missing); duodenum: 70.5882% (minimum 75%, Missing); esophagus: 68.5714% (minimum 70%, Missing); lung: 72.7273% (minimum 75%, Missing); lymph node: 39.3443% (minimum 70%, Missing); rectum: 60.0000% (minimum 70%, Missing); retina: 63.1579% (minimum 75%, Missing); small intestine: 68.5714% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); thymus: 42.8571% (minimum 65%, Missing)",-0.221429,-0.306557,-0.369048,0,4,partial,3.9,3.7,3.2,"bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163507,CIP2A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 38.0952% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); cerebral cortex: 68.5714% (minimum 75%, Missing); colon: 68.5714% (minimum 70%, Missing); duodenum: 70.5882% (minimum 75%, Missing); esophagus: 68.5714% (minimum 70%, Missing); lung: 72.7273% (minimum 75%, Missing); lymph node: 39.3443% (minimum 70%, Missing); rectum: 60.0000% (minimum 70%, Missing); retina: 63.1579% (minimum 75%, Missing); small intestine: 68.5714% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); thymus: 42.8571% (minimum 65%, Missing)",-0.221429,-0.306557,-0.369048,0,4,partial,3.9,3.7,3.2,"bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163507,CIP2A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 38.0952% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 75.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.5714% (minimum 75%, Baseline (adaptation disabled)); colon: 68.5714% (minimum 70%, Baseline (adaptation disabled)); duodenum: 70.5882% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.5714% (minimum 70%, Baseline (adaptation disabled)); lung: 72.7273% (minimum 75%, Baseline (adaptation disabled)); lymph node: 39.3443% (minimum 70%, Baseline (adaptation disabled)); rectum: 60.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 63.1579% (minimum 75%, Baseline (adaptation disabled)); small intestine: 68.5714% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.7273% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.8649% (minimum 65%, Baseline (adaptation disabled)); thymus: 42.8571% (minimum 65%, Baseline (adaptation disabled))",-0.221429,-0.306557,-0.369048,0,4,partial,3.9,3.7,3.2,"bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163507,CIP2A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 38.0048% (minimum 95%, Missing); adrenal gland: 58.6081% (minimum 99%, Missing); amygdala: 53.3333% (minimum 99%, Missing); basal ganglia: 52.6316% (minimum 99%, Missing); bone marrow: 43.7158% (minimum 99%, Missing); cerebellum: 60.8365% (minimum 99%, Missing); cerebral cortex: 48.3384% (minimum 99%, Missing); choroid plexus: 52.8053% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 57.9710% (minimum 99%, Missing); esophagus: 63.2411% (minimum 97%, Missing); heart muscle: 52.9801% (minimum 99%, Missing); hippocampal formation: 54.7945% (minimum 99%, Missing); hypothalamus: 51.2821% (minimum 99%, Missing); kidney: 52.6316% (minimum 99%, Missing); liver: 59.4796% (minimum 99%, Missing); lung: 56.9395% (minimum 99%, Missing); lymph node: 62.5000% (minimum 97%, Missing); midbrain: 53.6913% (minimum 99%, Missing); pancreas: 59.7015% (minimum 99%, Missing); parathyroid gland: 56.3380% (minimum 97%, Missing); pituitary gland: 54.2373% (minimum 99%, Missing); rectum: 62.7451% (minimum 97%, Missing); retina: 54.7945% (minimum 99%, Missing); salivary gland: 48.0480% (minimum 97%, Missing); skeletal muscle: 54.0541% (minimum 99%, Missing); skin: 62.5000% (minimum 95%, Missing); small intestine: 59.4796% (minimum 99%, Missing); smooth muscle: 58.3942% (minimum 99%, Missing); spinal cord: 62.0155% (minimum 99%, Missing); spleen: 62.0155% (minimum 95%, Missing); stomach: 59.9251% (minimum 97%, Missing); thymus: 53.8721% (minimum 95%, Missing); thyroid gland: 54.0541% (minimum 95%, Missing); tongue: 58.1818% (minimum 97%, Missing); urinary bladder: 58.8235% (minimum 97%, Missing)",-0.569952,-0.48952,-0.552842,0,2,partial,20.6,17.3,26.1,"adipose tissue: 26.1 nTPM (manageable, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); salivary gland: 17.3 nTPM (protected, limit 2); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); thyroid gland: 13.6 nTPM (manageable, limit 5); skeletal muscle: 13.6 nTPM (vital, limit 1); pituitary gland: 13.5 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.4 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 2); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 2); small intestine: 10.9 nTPM (vital, limit 1); liver: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 2); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 2); spinal cord: 9.8 nTPM (vital, limit 1); spleen: 9.8 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); lymph node: 9.6 nTPM (protected, limit 2); rectum: 9.5 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163512,AZI2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 38.0048% (minimum 65%, Missing); adrenal gland: 58.6081% (minimum 75%, Missing); amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 52.6316% (minimum 75%, Missing); bone marrow: 43.7158% (minimum 75%, Missing); cerebellum: 60.8365% (minimum 75%, Missing); cerebral cortex: 48.3384% (minimum 75%, Missing); choroid plexus: 52.8053% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 57.9710% (minimum 75%, Missing); esophagus: 63.2411% (minimum 70%, Missing); heart muscle: 52.9801% (minimum 75%, Missing); hippocampal formation: 54.7945% (minimum 75%, Missing); hypothalamus: 51.2821% (minimum 75%, Missing); kidney: 52.6316% (minimum 75%, Missing); liver: 59.4796% (minimum 75%, Missing); lung: 56.9395% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); midbrain: 53.6913% (minimum 75%, Missing); pancreas: 59.7015% (minimum 75%, Missing); parathyroid gland: 56.3380% (minimum 70%, Missing); pituitary gland: 54.2373% (minimum 75%, Missing); rectum: 62.7451% (minimum 70%, Missing); retina: 54.7945% (minimum 75%, Missing); salivary gland: 48.0480% (minimum 70%, Missing); skeletal muscle: 54.0541% (minimum 75%, Missing); skin: 62.5000% (minimum 65%, Missing); small intestine: 59.4796% (minimum 75%, Missing); smooth muscle: 58.3942% (minimum 75%, Missing); spinal cord: 62.0155% (minimum 75%, Missing); spleen: 62.0155% (minimum 65%, Missing); stomach: 59.9251% (minimum 70%, Missing); thymus: 53.8721% (minimum 65%, Missing); thyroid gland: 54.0541% (minimum 65%, Missing); tongue: 58.1818% (minimum 70%, Missing); urinary bladder: 58.8235% (minimum 70%, Missing)",-0.269952,-0.21952,-0.312842,0,2,partial,20.6,17.3,26.1,"adipose tissue: 26.1 nTPM (manageable, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); salivary gland: 17.3 nTPM (protected, limit 2); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); thyroid gland: 13.6 nTPM (manageable, limit 5); skeletal muscle: 13.6 nTPM (vital, limit 1); pituitary gland: 13.5 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.4 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 2); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 2); small intestine: 10.9 nTPM (vital, limit 1); liver: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 2); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 2); spinal cord: 9.8 nTPM (vital, limit 1); spleen: 9.8 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); lymph node: 9.6 nTPM (protected, limit 2); rectum: 9.5 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163512,AZI2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 38.0048% (minimum 65%, Missing); adrenal gland: 58.6081% (minimum 75%, Missing); amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 52.6316% (minimum 75%, Missing); bone marrow: 43.7158% (minimum 75%, Missing); cerebellum: 60.8365% (minimum 75%, Missing); cerebral cortex: 48.3384% (minimum 75%, Missing); choroid plexus: 52.8053% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 57.9710% (minimum 75%, Missing); esophagus: 63.2411% (minimum 70%, Missing); heart muscle: 52.9801% (minimum 75%, Missing); hippocampal formation: 54.7945% (minimum 75%, Missing); hypothalamus: 51.2821% (minimum 75%, Missing); kidney: 52.6316% (minimum 75%, Missing); liver: 59.4796% (minimum 75%, Missing); lung: 56.9395% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); midbrain: 53.6913% (minimum 75%, Missing); pancreas: 59.7015% (minimum 75%, Missing); parathyroid gland: 56.3380% (minimum 70%, Missing); pituitary gland: 54.2373% (minimum 75%, Missing); rectum: 62.7451% (minimum 70%, Missing); retina: 54.7945% (minimum 75%, Missing); salivary gland: 48.0480% (minimum 70%, Missing); skeletal muscle: 54.0541% (minimum 75%, Missing); skin: 62.5000% (minimum 65%, Missing); small intestine: 59.4796% (minimum 75%, Missing); smooth muscle: 58.3942% (minimum 75%, Missing); spinal cord: 62.0155% (minimum 75%, Missing); spleen: 62.0155% (minimum 65%, Missing); stomach: 59.9251% (minimum 70%, Missing); thymus: 53.8721% (minimum 65%, Missing); thyroid gland: 54.0541% (minimum 65%, Missing); tongue: 58.1818% (minimum 70%, Missing); urinary bladder: 58.8235% (minimum 70%, Missing)",-0.269952,-0.21952,-0.312842,0,2,partial,20.6,17.3,26.1,"adipose tissue: 26.1 nTPM (manageable, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); salivary gland: 17.3 nTPM (protected, limit 3); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); thyroid gland: 13.6 nTPM (manageable, limit 5); skeletal muscle: 13.6 nTPM (vital, limit 1); pituitary gland: 13.5 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.4 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 3); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 3); small intestine: 10.9 nTPM (vital, limit 1); liver: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 3); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 3); spinal cord: 9.8 nTPM (vital, limit 1); spleen: 9.8 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); lymph node: 9.6 nTPM (protected, limit 3); rectum: 9.5 nTPM (protected, limit 3); esophagus: 9.3 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163512,AZI2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 38.0048% (minimum 65%, Missing); adrenal gland: 58.6081% (minimum 75%, Missing); amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 52.6316% (minimum 75%, Missing); bone marrow: 43.7158% (minimum 75%, Missing); cerebellum: 60.8365% (minimum 75%, Missing); cerebral cortex: 48.3384% (minimum 75%, Missing); choroid plexus: 52.8053% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 57.9710% (minimum 75%, Missing); esophagus: 63.2411% (minimum 70%, Missing); heart muscle: 52.9801% (minimum 75%, Missing); hippocampal formation: 54.7945% (minimum 75%, Missing); hypothalamus: 51.2821% (minimum 75%, Missing); kidney: 52.6316% (minimum 75%, Missing); liver: 59.4796% (minimum 75%, Missing); lung: 56.9395% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); midbrain: 53.6913% (minimum 75%, Missing); pancreas: 59.7015% (minimum 75%, Missing); parathyroid gland: 56.3380% (minimum 70%, Missing); pituitary gland: 54.2373% (minimum 75%, Missing); rectum: 62.7451% (minimum 70%, Missing); retina: 54.7945% (minimum 75%, Missing); salivary gland: 48.0480% (minimum 70%, Missing); skeletal muscle: 54.0541% (minimum 75%, Missing); skin: 62.5000% (minimum 65%, Missing); small intestine: 59.4796% (minimum 75%, Missing); smooth muscle: 58.3942% (minimum 75%, Missing); spinal cord: 62.0155% (minimum 75%, Missing); spleen: 62.0155% (minimum 65%, Missing); stomach: 59.9251% (minimum 70%, Missing); thymus: 53.8721% (minimum 65%, Missing); thyroid gland: 54.0541% (minimum 65%, Missing); tongue: 58.1818% (minimum 70%, Missing); urinary bladder: 58.8235% (minimum 70%, Missing)",-0.269952,-0.21952,-0.312842,0,2,partial,20.6,17.3,26.1,"adipose tissue: 26.1 nTPM (manageable, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); salivary gland: 17.3 nTPM (protected, limit 3); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); thyroid gland: 13.6 nTPM (manageable, limit 5); skeletal muscle: 13.6 nTPM (vital, limit 1); pituitary gland: 13.5 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.4 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 3); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 3); small intestine: 10.9 nTPM (vital, limit 1); liver: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 3); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 3); spinal cord: 9.8 nTPM (vital, limit 1); spleen: 9.8 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); lymph node: 9.6 nTPM (protected, limit 3); rectum: 9.5 nTPM (protected, limit 3); esophagus: 9.3 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163512,AZI2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 38.0048% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 58.6081% (minimum 75%, Baseline (adaptation disabled)); amygdala: 53.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 52.6316% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 43.7158% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.8365% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.3384% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 52.8053% (minimum 75%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.9710% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.2411% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.9801% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.7945% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 51.2821% (minimum 75%, Baseline (adaptation disabled)); kidney: 52.6316% (minimum 75%, Baseline (adaptation disabled)); liver: 59.4796% (minimum 75%, Baseline (adaptation disabled)); lung: 56.9395% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.5000% (minimum 70%, Baseline (adaptation disabled)); midbrain: 53.6913% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.7015% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 56.3380% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 54.2373% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.7451% (minimum 70%, Baseline (adaptation disabled)); retina: 54.7945% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 48.0480% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 54.0541% (minimum 75%, Baseline (adaptation disabled)); skin: 62.5000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.4796% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.3942% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.0155% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.0155% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.9251% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.8721% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.0541% (minimum 65%, Baseline (adaptation disabled)); tongue: 58.1818% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.8235% (minimum 70%, Baseline (adaptation disabled))",-0.269952,-0.21952,-0.312842,0,2,partial,20.6,17.3,26.1,"adipose tissue: 26.1 nTPM (manageable, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); salivary gland: 17.3 nTPM (protected, limit 3); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); thyroid gland: 13.6 nTPM (manageable, limit 5); skeletal muscle: 13.6 nTPM (vital, limit 1); pituitary gland: 13.5 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.4 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 3); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 3); small intestine: 10.9 nTPM (vital, limit 1); liver: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 3); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 3); spinal cord: 9.8 nTPM (vital, limit 1); spleen: 9.8 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); lymph node: 9.6 nTPM (protected, limit 3); rectum: 9.5 nTPM (protected, limit 3); esophagus: 9.3 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163512,AZI2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.0637% (minimum 95%, Missing); adrenal gland: 61.3440% (minimum 99%, Missing); amygdala: 82.5425% (minimum 99%, Missing); basal ganglia: 81.9556% (minimum 99%, Missing); bone marrow: 59.4455% (minimum 99%, Missing); cerebellum: 83.2130% (minimum 99%, Missing); cerebral cortex: 77.4790% (minimum 99%, Missing); choroid plexus: 80.6649% (minimum 99%, Missing); colon: 61.5077% (minimum 97%, Missing); duodenum: 66.4265% (minimum 99%, Missing); esophagus: 68.0443% (minimum 97%, Missing); heart muscle: 65.9042% (minimum 99%, Missing); hippocampal formation: 82.9883% (minimum 99%, Missing); hypothalamus: 82.8392% (minimum 99%, Missing); kidney: 65.8101% (minimum 99%, Missing); liver: 55.9466% (minimum 99%, Missing); lung: 65.9042% (minimum 99%, Missing); lymph node: 61.1812% (minimum 97%, Missing); midbrain: 81.8828% (minimum 99%, Missing); pancreas: 67.4963% (minimum 99%, Missing); parathyroid gland: 55.4420% (minimum 97%, Missing); pituitary gland: 79.2096% (minimum 99%, Missing); rectum: 60.7779% (minimum 97%, Missing); retina: 71.1420% (minimum 99%, Missing); salivary gland: 65.5295% (minimum 97%, Missing); skeletal muscle: 60.6180% (minimum 99%, Missing); skin: 67.8940% (minimum 95%, Missing); small intestine: 65.8571% (minimum 99%, Missing); smooth muscle: 62.3816% (minimum 99%, Missing); spinal cord: 78.2683% (minimum 99%, Missing); spleen: 68.1449% (minimum 90%, Approved); stomach: 63.1940% (minimum 97%, Missing); thymus: 56.8785% (minimum 95%, Missing); thyroid gland: 54.0445% (minimum 95%, Missing); tongue: 62.3816% (minimum 97%, Missing); urinary bladder: 62.8065% (minimum 97%, Missing)",-0.409555,-0.41558,-0.430534,0,4,partial,72.6,74.1,78.4,"thyroid gland: 78.4 nTPM (manageable, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 2); liver: 72.6 nTPM (vital, limit 1); thymus: 69.9 nTPM (manageable, limit 5); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 2); lymph node: 58.5 nTPM (protected, limit 2); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 2); smooth muscle: 55.6 nTPM (vital, limit 1); tongue: 55.6 nTPM (protected, limit 2); urinary bladder: 54.6 nTPM (protected, limit 2); stomach: 53.7 nTPM (protected, limit 2); salivary gland: 48.5 nTPM (protected, limit 2); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); skin: 43.6 nTPM (manageable, limit 5); esophagus: 43.3 nTPM (protected, limit 2); spleen: 43.1 nTPM (manageable, limit 10); adipose tissue: 41.3 nTPM (manageable, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163527,STT3B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 61.3440% (minimum 75%, Missing); bone marrow: 59.4455% (minimum 75%, Missing); colon: 61.5077% (minimum 70%, Missing); duodenum: 66.4265% (minimum 75%, Missing); esophagus: 68.0443% (minimum 70%, Missing); heart muscle: 65.9042% (minimum 75%, Missing); kidney: 65.8101% (minimum 75%, Missing); liver: 55.9466% (minimum 75%, Missing); lung: 65.9042% (minimum 75%, Missing); lymph node: 61.1812% (minimum 70%, Missing); pancreas: 67.4963% (minimum 75%, Missing); parathyroid gland: 55.4420% (minimum 70%, Missing); rectum: 60.7779% (minimum 70%, Missing); retina: 71.1420% (minimum 75%, Missing); salivary gland: 65.5295% (minimum 70%, Missing); skeletal muscle: 60.6180% (minimum 75%, Missing); small intestine: 65.8571% (minimum 75%, Missing); smooth muscle: 62.3816% (minimum 75%, Missing); stomach: 63.1940% (minimum 70%, Missing); thymus: 56.8785% (minimum 65%, Missing); thyroid gland: 54.0445% (minimum 65%, Missing); tongue: 62.3816% (minimum 70%, Missing); urinary bladder: 62.8065% (minimum 70%, Missing)",-0.109555,-0.14558,-0.190534,0,4,partial,72.6,74.1,78.4,"thyroid gland: 78.4 nTPM (manageable, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 2); liver: 72.6 nTPM (vital, limit 1); thymus: 69.9 nTPM (manageable, limit 5); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 2); lymph node: 58.5 nTPM (protected, limit 2); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 2); smooth muscle: 55.6 nTPM (vital, limit 1); tongue: 55.6 nTPM (protected, limit 2); urinary bladder: 54.6 nTPM (protected, limit 2); stomach: 53.7 nTPM (protected, limit 2); salivary gland: 48.5 nTPM (protected, limit 2); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); skin: 43.6 nTPM (manageable, limit 5); esophagus: 43.3 nTPM (protected, limit 2); spleen: 43.1 nTPM (manageable, limit 10); adipose tissue: 41.3 nTPM (manageable, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163527,STT3B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 61.3440% (minimum 75%, Missing); bone marrow: 59.4455% (minimum 75%, Missing); colon: 61.5077% (minimum 70%, Missing); duodenum: 66.4265% (minimum 75%, Missing); esophagus: 68.0443% (minimum 70%, Missing); heart muscle: 65.9042% (minimum 75%, Missing); kidney: 65.8101% (minimum 75%, Missing); liver: 55.9466% (minimum 75%, Missing); lung: 65.9042% (minimum 75%, Missing); lymph node: 61.1812% (minimum 70%, Missing); pancreas: 67.4963% (minimum 75%, Missing); parathyroid gland: 55.4420% (minimum 70%, Missing); rectum: 60.7779% (minimum 70%, Missing); retina: 71.1420% (minimum 75%, Missing); salivary gland: 65.5295% (minimum 70%, Missing); skeletal muscle: 60.6180% (minimum 75%, Missing); small intestine: 65.8571% (minimum 75%, Missing); smooth muscle: 62.3816% (minimum 75%, Missing); stomach: 63.1940% (minimum 70%, Missing); thymus: 56.8785% (minimum 65%, Missing); thyroid gland: 54.0445% (minimum 65%, Missing); tongue: 62.3816% (minimum 70%, Missing); urinary bladder: 62.8065% (minimum 70%, Missing)",-0.109555,-0.14558,-0.190534,0,4,partial,72.6,74.1,78.4,"thyroid gland: 78.4 nTPM (manageable, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 3); liver: 72.6 nTPM (vital, limit 1); thymus: 69.9 nTPM (manageable, limit 5); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 3); lymph node: 58.5 nTPM (protected, limit 3); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 3); smooth muscle: 55.6 nTPM (vital, limit 1); tongue: 55.6 nTPM (protected, limit 3); urinary bladder: 54.6 nTPM (protected, limit 3); stomach: 53.7 nTPM (protected, limit 3); salivary gland: 48.5 nTPM (protected, limit 3); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); skin: 43.6 nTPM (manageable, limit 5); esophagus: 43.3 nTPM (protected, limit 3); spleen: 43.1 nTPM (manageable, limit 10); adipose tissue: 41.3 nTPM (manageable, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163527,STT3B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 61.3440% (minimum 75%, Missing); bone marrow: 59.4455% (minimum 75%, Missing); colon: 61.5077% (minimum 70%, Missing); duodenum: 66.4265% (minimum 75%, Missing); esophagus: 68.0443% (minimum 70%, Missing); heart muscle: 65.9042% (minimum 75%, Missing); kidney: 65.8101% (minimum 75%, Missing); liver: 55.9466% (minimum 75%, Missing); lung: 65.9042% (minimum 75%, Missing); lymph node: 61.1812% (minimum 70%, Missing); pancreas: 67.4963% (minimum 75%, Missing); parathyroid gland: 55.4420% (minimum 70%, Missing); rectum: 60.7779% (minimum 70%, Missing); retina: 71.1420% (minimum 75%, Missing); salivary gland: 65.5295% (minimum 70%, Missing); skeletal muscle: 60.6180% (minimum 75%, Missing); small intestine: 65.8571% (minimum 75%, Missing); smooth muscle: 62.3816% (minimum 75%, Missing); stomach: 63.1940% (minimum 70%, Missing); thymus: 56.8785% (minimum 65%, Missing); thyroid gland: 54.0445% (minimum 65%, Missing); tongue: 62.3816% (minimum 70%, Missing); urinary bladder: 62.8065% (minimum 70%, Missing)",-0.109555,-0.14558,-0.190534,0,4,partial,72.6,74.1,78.4,"thyroid gland: 78.4 nTPM (manageable, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 3); liver: 72.6 nTPM (vital, limit 1); thymus: 69.9 nTPM (manageable, limit 5); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 3); lymph node: 58.5 nTPM (protected, limit 3); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 3); smooth muscle: 55.6 nTPM (vital, limit 1); tongue: 55.6 nTPM (protected, limit 3); urinary bladder: 54.6 nTPM (protected, limit 3); stomach: 53.7 nTPM (protected, limit 3); salivary gland: 48.5 nTPM (protected, limit 3); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); skin: 43.6 nTPM (manageable, limit 5); esophagus: 43.3 nTPM (protected, limit 3); spleen: 43.1 nTPM (manageable, limit 10); adipose tissue: 41.3 nTPM (manageable, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163527,STT3B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 61.3440% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 59.4455% (minimum 75%, Baseline (adaptation disabled)); colon: 61.5077% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.4265% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.0443% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.9042% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.8101% (minimum 75%, Baseline (adaptation disabled)); liver: 55.9466% (minimum 75%, Baseline (adaptation disabled)); lung: 65.9042% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.1812% (minimum 70%, Baseline (adaptation disabled)); pancreas: 67.4963% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.4420% (minimum 70%, Baseline (adaptation disabled)); rectum: 60.7779% (minimum 70%, Baseline (adaptation disabled)); retina: 71.1420% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.5295% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.6180% (minimum 75%, Baseline (adaptation disabled)); small intestine: 65.8571% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.3816% (minimum 75%, Baseline (adaptation disabled)); stomach: 63.1940% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.8785% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.0445% (minimum 65%, Baseline (adaptation disabled)); tongue: 62.3816% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.8065% (minimum 70%, Baseline (adaptation disabled))",-0.109555,-0.14558,-0.190534,0,4,partial,72.6,74.1,78.4,"thyroid gland: 78.4 nTPM (manageable, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 3); liver: 72.6 nTPM (vital, limit 1); thymus: 69.9 nTPM (manageable, limit 5); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 3); lymph node: 58.5 nTPM (protected, limit 3); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 3); smooth muscle: 55.6 nTPM (vital, limit 1); tongue: 55.6 nTPM (protected, limit 3); urinary bladder: 54.6 nTPM (protected, limit 3); stomach: 53.7 nTPM (protected, limit 3); salivary gland: 48.5 nTPM (protected, limit 3); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); skin: 43.6 nTPM (manageable, limit 5); esophagus: 43.3 nTPM (protected, limit 3); spleen: 43.1 nTPM (manageable, limit 5); adipose tissue: 41.3 nTPM (manageable, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163527,STT3B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 96.9697% (minimum 99%, Missing)",0.019697,0.03,-0.020303,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163530,DPPA2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.319697,0.3,0.219697,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163530,DPPA2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.319697,0.3,0.219697,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163530,DPPA2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.319697,0.3,0.219697,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163530,DPPA2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.319697,0.3,0.219697,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163530,DPPA2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.4424% (minimum 99%, Missing); basal ganglia: 98.4424% (minimum 99%, Missing); bone marrow: 82.5065% (minimum 95%, Enhanced); colon: 91.3295% (minimum 97%, Missing); duodenum: 92.9412% (minimum 99%, Missing); esophagus: 93.2153% (minimum 97%, Missing); hippocampal formation: 98.4424% (minimum 99%, Missing); hypothalamus: 98.1366% (minimum 99%, Missing); lymph node: 80.2030% (minimum 97%, Missing); midbrain: 98.1366% (minimum 99%, Missing); rectum: 91.0663% (minimum 97%, Missing); retina: 97.2308% (minimum 99%, Missing); skin: 93.4911% (minimum 95%, Missing); small intestine: 92.6686% (minimum 99%, Missing); smooth muscle: 94.0476% (minimum 95%, Enhanced); spinal cord: 98.1366% (minimum 99%, Missing); stomach: 94.8949% (minimum 97%, Missing); thymus: 68.5466% (minimum 95%, Missing)",-0.264534,-0.16797,-0.124935,0,12,partial,6.7,7.8,14.5,"thymus: 14.5 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); bone marrow: 6.7 nTPM (vital, limit 6); rectum: 3.1 nTPM (protected, limit 2); colon: 3 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2)",bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163535,SGO2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0354664,0.10203,0.176686,0,12,partial,6.7,7.8,14.5,"thymus: 14.5 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); bone marrow: 6.7 nTPM (vital, limit 6); rectum: 3.1 nTPM (protected, limit 2); colon: 3 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2)",bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163535,SGO2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0354664,0.10203,0.176686,0,12,partial,6.7,7.8,14.5,"thymus: 14.5 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); bone marrow: 6.7 nTPM (vital, limit 6); rectum: 3.1 nTPM (protected, limit 3); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163535,SGO2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0354664,0.10203,0.176686,0,12,partial,6.7,7.8,14.5,"thymus: 14.5 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); bone marrow: 6.7 nTPM (vital, limit 6); rectum: 3.1 nTPM (protected, limit 3); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163535,SGO2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0354664,0.10203,0.0750653,0,12,partial,6.7,7.8,14.5,"thymus: 14.5 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); bone marrow: 6.7 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163535,SGO2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 2.0970% (minimum 99%, Missing); liver: 94.1176% (minimum 95%, Enhanced); lung: 94.1176% (minimum 95%, Enhanced); spleen: 59.2593% (minimum 60%, Enhanced); thymus: 80.0000% (minimum 95%, Missing)",-0.15,0.03,-0.96903,0,1,partial,74.7,0,1.1,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163554,SPTA1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 2.0970% (minimum 75%, Missing)",0.0925926,0.3,-0.72903,0,1,partial,74.7,0,1.1,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163554,SPTA1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 2.0970% (minimum 75%, Missing)",0.0925926,0.3,-0.72903,0,1,partial,74.7,0,1.1,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163554,SPTA1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 2.0970% (minimum 75%, Missing)",0.0925926,0.3,-0.72903,0,1,partial,74.7,0,1.1,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163554,SPTA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 2.0970% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.2593% (minimum 65%, Baseline (adaptation disabled))",-0.0574074,0.3,-0.72903,0,1,partial,74.7,0,1.1,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163554,SPTA1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.0265517,0.00312715,0,4,partial,0.6,0.6,1.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163645,ERICH6,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296552,0.243127,0,4,partial,0.6,0.6,1.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163645,ERICH6,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296552,0.243127,0,4,partial,0.6,0.6,1.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163645,ERICH6,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296552,0.243127,0,4,partial,0.6,0.6,1.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163645,ERICH6,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.306954,0.279661,0.229661,0,4,partial,0.6,0.6,1.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163645,ERICH6,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 5.8824% (minimum 99%, Missing); duodenum: 18.7500% (minimum 99%, Missing); pituitary gland: 60.0000% (minimum 99%, Missing); retina: 2.3622% (minimum 99%, Missing); small intestine: 60.0000% (minimum 99%, Missing); spinal cord: 60.0000% (minimum 99%, Missing); thymus: 75.0000% (minimum 95%, Missing)",-0.2,0.03,-0.966378,0,80,unavailable,12.4,0,0.1,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163646,CLRN1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 5.8824% (minimum 75%, Missing); duodenum: 18.7500% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 2.3622% (minimum 75%, Missing); small intestine: 60.0000% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing)",0.1,0.3,-0.726378,0,80,unavailable,12.4,0,0.1,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163646,CLRN1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 5.8824% (minimum 75%, Missing); duodenum: 18.7500% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 2.3622% (minimum 75%, Missing); small intestine: 60.0000% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing)",0.1,0.3,-0.726378,0,80,unavailable,12.4,0,0.1,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163646,CLRN1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 5.8824% (minimum 75%, Missing); duodenum: 18.7500% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 2.3622% (minimum 75%, Missing); small intestine: 60.0000% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing)",0.1,0.3,-0.726378,0,80,unavailable,12.4,0,0.1,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163646,CLRN1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 5.8824% (minimum 75%, Baseline (adaptation disabled)); duodenum: 18.7500% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 2.3622% (minimum 75%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 60.0000% (minimum 75%, Baseline (adaptation disabled))",0.1,0.3,-0.726378,0,80,unavailable,12.4,0,0.1,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163646,CLRN1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.4563% (minimum 95%, Missing); adrenal gland: 49.0741% (minimum 99%, Missing); amygdala: 56.9892% (minimum 99%, Missing); basal ganglia: 51.4563% (minimum 99%, Missing); bone marrow: 53.0000% (minimum 99%, Missing); cerebellum: 45.2991% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); choroid plexus: 60.2273% (minimum 99%, Missing); colon: 44.5378% (minimum 97%, Missing); duodenum: 44.5378% (minimum 99%, Missing); esophagus: 48.1818% (minimum 97%, Missing); heart muscle: 33.5443% (minimum 99%, Missing); hippocampal formation: 57.6087% (minimum 99%, Missing); hypothalamus: 56.3830% (minimum 99%, Missing); kidney: 37.8571% (minimum 99%, Missing); liver: 32.1212% (minimum 99%, Missing); lung: 57.6087% (minimum 99%, Missing); lymph node: 57.6087% (minimum 97%, Missing); midbrain: 59.5506% (minimum 99%, Missing); pancreas: 47.3214% (minimum 99%, Missing); parathyroid gland: 41.7323% (minimum 97%, Missing); pituitary gland: 48.1818% (minimum 99%, Missing); rectum: 46.0870% (minimum 97%, Missing); retina: 51.9608% (minimum 99%, Missing); salivary gland: 52.4752% (minimum 97%, Missing); skeletal muscle: 11.9101% (minimum 99%, Missing); skin: 50.9615% (minimum 95%, Missing); small intestine: 44.1667% (minimum 99%, Missing); smooth muscle: 43.4426% (minimum 99%, Missing); spinal cord: 61.6279% (minimum 99%, Missing); spleen: 48.6239% (minimum 95%, Missing); stomach: 50.4762% (minimum 97%, Missing); thymus: 45.6897% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 12.3832% (minimum 97%, Missing); urinary bladder: 51.4563% (minimum 97%, Missing)",-0.493103,-0.846168,-0.870899,0,80,unavailable,39.2,37.5,6.3,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 2); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 2); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); rectum: 6.2 nTPM (protected, limit 2); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 2); pituitary gland: 5.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); stomach: 5.2 nTPM (protected, limit 2); skin: 5.1 nTPM (manageable, limit 5); urinary bladder: 5 nTPM (protected, limit 2); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163684,RPP14,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.4563% (minimum 65%, Missing); adrenal gland: 49.0741% (minimum 75%, Missing); amygdala: 56.9892% (minimum 75%, Missing); basal ganglia: 51.4563% (minimum 75%, Missing); bone marrow: 53.0000% (minimum 75%, Missing); cerebellum: 45.2991% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); choroid plexus: 60.2273% (minimum 75%, Missing); colon: 44.5378% (minimum 70%, Missing); duodenum: 44.5378% (minimum 75%, Missing); esophagus: 48.1818% (minimum 70%, Missing); heart muscle: 33.5443% (minimum 75%, Missing); hippocampal formation: 57.6087% (minimum 75%, Missing); hypothalamus: 56.3830% (minimum 75%, Missing); kidney: 37.8571% (minimum 75%, Missing); liver: 32.1212% (minimum 75%, Missing); lung: 57.6087% (minimum 75%, Missing); lymph node: 57.6087% (minimum 70%, Missing); midbrain: 59.5506% (minimum 75%, Missing); pancreas: 47.3214% (minimum 75%, Missing); parathyroid gland: 41.7323% (minimum 70%, Missing); pituitary gland: 48.1818% (minimum 75%, Missing); rectum: 46.0870% (minimum 70%, Missing); retina: 51.9608% (minimum 75%, Missing); salivary gland: 52.4752% (minimum 70%, Missing); skeletal muscle: 11.9101% (minimum 75%, Missing); skin: 50.9615% (minimum 65%, Missing); small intestine: 44.1667% (minimum 75%, Missing); smooth muscle: 43.4426% (minimum 75%, Missing); spinal cord: 61.6279% (minimum 75%, Missing); spleen: 48.6239% (minimum 65%, Missing); stomach: 50.4762% (minimum 70%, Missing); thymus: 45.6897% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 12.3832% (minimum 70%, Missing); urinary bladder: 51.4563% (minimum 70%, Missing)",-0.193103,-0.576168,-0.630899,0,80,unavailable,39.2,37.5,6.3,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 2); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 2); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); rectum: 6.2 nTPM (protected, limit 2); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 2); pituitary gland: 5.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); stomach: 5.2 nTPM (protected, limit 2); skin: 5.1 nTPM (manageable, limit 5); urinary bladder: 5 nTPM (protected, limit 2); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163684,RPP14,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.4563% (minimum 65%, Missing); adrenal gland: 49.0741% (minimum 75%, Missing); amygdala: 56.9892% (minimum 75%, Missing); basal ganglia: 51.4563% (minimum 75%, Missing); bone marrow: 53.0000% (minimum 75%, Missing); cerebellum: 45.2991% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); choroid plexus: 60.2273% (minimum 75%, Missing); colon: 44.5378% (minimum 70%, Missing); duodenum: 44.5378% (minimum 75%, Missing); esophagus: 48.1818% (minimum 70%, Missing); heart muscle: 33.5443% (minimum 75%, Missing); hippocampal formation: 57.6087% (minimum 75%, Missing); hypothalamus: 56.3830% (minimum 75%, Missing); kidney: 37.8571% (minimum 75%, Missing); liver: 32.1212% (minimum 75%, Missing); lung: 57.6087% (minimum 75%, Missing); lymph node: 57.6087% (minimum 70%, Missing); midbrain: 59.5506% (minimum 75%, Missing); pancreas: 47.3214% (minimum 75%, Missing); parathyroid gland: 41.7323% (minimum 70%, Missing); pituitary gland: 48.1818% (minimum 75%, Missing); rectum: 46.0870% (minimum 70%, Missing); retina: 51.9608% (minimum 75%, Missing); salivary gland: 52.4752% (minimum 70%, Missing); skeletal muscle: 11.9101% (minimum 75%, Missing); skin: 50.9615% (minimum 65%, Missing); small intestine: 44.1667% (minimum 75%, Missing); smooth muscle: 43.4426% (minimum 75%, Missing); spinal cord: 61.6279% (minimum 75%, Missing); spleen: 48.6239% (minimum 65%, Missing); stomach: 50.4762% (minimum 70%, Missing); thymus: 45.6897% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 12.3832% (minimum 70%, Missing); urinary bladder: 51.4563% (minimum 70%, Missing)",-0.193103,-0.576168,-0.630899,0,80,unavailable,39.2,37.5,6.3,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 3); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 3); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); rectum: 6.2 nTPM (protected, limit 3); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 3); pituitary gland: 5.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); stomach: 5.2 nTPM (protected, limit 3); skin: 5.1 nTPM (manageable, limit 5); urinary bladder: 5 nTPM (protected, limit 3); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163684,RPP14,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.4563% (minimum 65%, Missing); adrenal gland: 49.0741% (minimum 75%, Missing); amygdala: 56.9892% (minimum 75%, Missing); basal ganglia: 51.4563% (minimum 75%, Missing); bone marrow: 53.0000% (minimum 75%, Missing); cerebellum: 45.2991% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); choroid plexus: 60.2273% (minimum 75%, Missing); colon: 44.5378% (minimum 70%, Missing); duodenum: 44.5378% (minimum 75%, Missing); esophagus: 48.1818% (minimum 70%, Missing); heart muscle: 33.5443% (minimum 75%, Missing); hippocampal formation: 57.6087% (minimum 75%, Missing); hypothalamus: 56.3830% (minimum 75%, Missing); kidney: 37.8571% (minimum 75%, Missing); liver: 32.1212% (minimum 75%, Missing); lung: 57.6087% (minimum 75%, Missing); lymph node: 57.6087% (minimum 70%, Missing); midbrain: 59.5506% (minimum 75%, Missing); pancreas: 47.3214% (minimum 75%, Missing); parathyroid gland: 41.7323% (minimum 70%, Missing); pituitary gland: 48.1818% (minimum 75%, Missing); rectum: 46.0870% (minimum 70%, Missing); retina: 51.9608% (minimum 75%, Missing); salivary gland: 52.4752% (minimum 70%, Missing); skeletal muscle: 11.9101% (minimum 75%, Missing); skin: 50.9615% (minimum 65%, Missing); small intestine: 44.1667% (minimum 75%, Missing); smooth muscle: 43.4426% (minimum 75%, Missing); spinal cord: 61.6279% (minimum 75%, Missing); spleen: 48.6239% (minimum 65%, Missing); stomach: 50.4762% (minimum 70%, Missing); thymus: 45.6897% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 12.3832% (minimum 70%, Missing); urinary bladder: 51.4563% (minimum 70%, Missing)",-0.193103,-0.576168,-0.630899,0,80,unavailable,39.2,37.5,6.3,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 3); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 3); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); rectum: 6.2 nTPM (protected, limit 3); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 3); pituitary gland: 5.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); stomach: 5.2 nTPM (protected, limit 3); skin: 5.1 nTPM (manageable, limit 5); urinary bladder: 5 nTPM (protected, limit 3); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163684,RPP14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.4563% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 49.0741% (minimum 75%, Baseline (adaptation disabled)); amygdala: 56.9892% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 51.4563% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 53.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 45.2991% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.2273% (minimum 75%, Baseline (adaptation disabled)); colon: 44.5378% (minimum 70%, Baseline (adaptation disabled)); duodenum: 44.5378% (minimum 75%, Baseline (adaptation disabled)); esophagus: 48.1818% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 33.5443% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.6087% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 56.3830% (minimum 75%, Baseline (adaptation disabled)); kidney: 37.8571% (minimum 75%, Baseline (adaptation disabled)); liver: 32.1212% (minimum 75%, Baseline (adaptation disabled)); lung: 57.6087% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.6087% (minimum 70%, Baseline (adaptation disabled)); midbrain: 59.5506% (minimum 75%, Baseline (adaptation disabled)); pancreas: 47.3214% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 41.7323% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 48.1818% (minimum 75%, Baseline (adaptation disabled)); rectum: 46.0870% (minimum 70%, Baseline (adaptation disabled)); retina: 51.9608% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 52.4752% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 11.9101% (minimum 75%, Baseline (adaptation disabled)); skin: 50.9615% (minimum 65%, Baseline (adaptation disabled)); small intestine: 44.1667% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 43.4426% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.6279% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.6239% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.4762% (minimum 70%, Baseline (adaptation disabled)); thymus: 45.6897% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 12.3832% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.4563% (minimum 70%, Baseline (adaptation disabled))",-0.193103,-0.576168,-0.630899,0,80,unavailable,39.2,37.5,6.3,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 3); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 3); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); rectum: 6.2 nTPM (protected, limit 3); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 3); pituitary gland: 5.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); stomach: 5.2 nTPM (protected, limit 3); skin: 5.1 nTPM (manageable, limit 5); urinary bladder: 5 nTPM (protected, limit 3); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163684,RPP14,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5947% (minimum 99%, Missing); amygdala: 98.6364% (minimum 99%, Missing); basal ganglia: 97.7477% (minimum 99%, Missing); cerebral cortex: 97.7477% (minimum 99%, Missing); esophagus: 73.8095% (minimum 97%, Missing); hippocampal formation: 98.6364% (minimum 99%, Missing); hypothalamus: 97.7477% (minimum 99%, Missing); kidney: 98.1900% (minimum 99%, Missing); liver: 95.5947% (minimum 99%, Missing); lung: 98.1900% (minimum 99%, Missing); lymph node: 93.5345% (minimum 97%, Missing); midbrain: 98.6364% (minimum 99%, Missing); pancreas: 97.7477% (minimum 99%, Missing); parathyroid gland: 96.8750% (minimum 97%, Missing); pituitary gland: 92.3404% (minimum 99%, Missing); rectum: 96.8750% (minimum 97%, Missing); retina: 98.1900% (minimum 99%, Missing); salivary gland: 91.9492% (minimum 97%, Missing); smooth muscle: 98.6364% (minimum 99%, Missing)",0.0274775,-0.231905,-0.0665957,0,80,unavailable,1.8,7.7,0.5,"esophagus: 7.7 nTPM (protected, limit 2); pituitary gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163689,CFAP20DC,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.327477,0.0380952,0.173404,0,80,unavailable,1.8,7.7,0.5,"esophagus: 7.7 nTPM (protected, limit 2); pituitary gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163689,CFAP20DC,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.327477,0.0380952,0.173404,0,80,unavailable,1.8,7.7,0.5,"esophagus: 7.7 nTPM (protected, limit 3); pituitary gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163689,CFAP20DC,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.327477,0.0380952,0.173404,0,80,unavailable,1.8,7.7,0.5,"esophagus: 7.7 nTPM (protected, limit 3); pituitary gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163689,CFAP20DC,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.327477,0.0380952,0.173404,0,80,unavailable,1.8,7.7,0.5,"esophagus: 7.7 nTPM (protected, limit 3); pituitary gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163689,CFAP20DC,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.3580% (minimum 99%, Missing)",0.0433665,0.0283333,-0.00642036,0,80,unavailable,1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163705,FANCD2OS,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343367,0.298333,0.23358,0,80,unavailable,1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163705,FANCD2OS,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343367,0.298333,0.23358,0,80,unavailable,1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163705,FANCD2OS,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343367,0.298333,0.23358,0,80,unavailable,1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163705,FANCD2OS,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343367,0.298333,0.23358,0,80,unavailable,1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163705,FANCD2OS,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 92.3077% (minimum 99%, Missing); duodenum: 98.5075% (minimum 99%, Missing); kidney: 96.3504% (minimum 99%, Missing); liver: 98.5075% (minimum 99%, Missing); pancreas: 96.3504% (minimum 99%, Missing); retina: 96.3504% (minimum 99%, Missing); small intestine: 98.5075% (minimum 99%, Missing); smooth muscle: 98.5075% (minimum 99%, Missing)",0.0205882,0.00777778,-0.0669231,0,80,unavailable,1.1,0.3,0.4,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163746,PLSCR2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.320588,0.277778,0.173077,0,80,unavailable,1.1,0.3,0.4,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163746,PLSCR2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.320588,0.277778,0.173077,0,80,unavailable,1.1,0.3,0.4,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163746,PLSCR2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.320588,0.277778,0.173077,0,80,unavailable,1.1,0.3,0.4,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163746,PLSCR2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.320588,0.277778,0.173077,0,80,unavailable,1.1,0.3,0.4,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163746,PLSCR2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 98.5207% (minimum 99%, Missing); heart muscle: 98.8131% (minimum 99%, Missing); kidney: 98.5207% (minimum 99%, Missing); liver: 95.4155% (minimum 99%, Missing); pituitary gland: 98.5207% (minimum 99%, Missing); smooth muscle: 98.8131% (minimum 99%, Missing)",0.0124277,0.0152071,-0.0358453,0,80,unavailable,1.6,0.5,1.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163749,CCDC158,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312428,0.285207,0.204155,0,80,unavailable,1.6,0.5,1.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163749,CCDC158,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312428,0.285207,0.204155,0,80,unavailable,1.6,0.5,1.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163749,CCDC158,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312428,0.285207,0.204155,0,80,unavailable,1.6,0.5,1.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163749,CCDC158,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312428,0.285207,0.204155,0,80,unavailable,1.6,0.5,1.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163749,CCDC158,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 95.4071% (minimum 98%, Approved); heart muscle: 97.2340% (minimum 98%, Approved)",0.05,0.03,-0.025929,0,2,partial,2.2,0.1,0.1,"cerebral cortex: 2.2 nTPM (vital, limit 2)",,53,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163793,DNAJC5G,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.241323,0,2,partial,2.2,0.1,0.1,"cerebral cortex: 2.2 nTPM (vital, limit 2)",,53,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163793,DNAJC5G,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.241323,0,2,partial,2.2,0.1,0.1,"cerebral cortex: 2.2 nTPM (vital, limit 2)",,53,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163793,DNAJC5G,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.241323,0,2,partial,2.2,0.1,0.1,"cerebral cortex: 2.2 nTPM (vital, limit 2)",,53,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163793,DNAJC5G,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347817,0.297817,0.204071,0,2,partial,2.2,0.1,0.1,"cerebral cortex: 2.2 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,53,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163793,DNAJC5G,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.3855% (minimum 99%, Missing); basal ganglia: 96.0961% (minimum 99%, Missing); cerebellum: 93.2945% (minimum 95%, Enhanced); hippocampal formation: 96.0961% (minimum 99%, Missing); hypothalamus: 96.3855% (minimum 99%, Missing); midbrain: 96.6767% (minimum 99%, Missing); pituitary gland: 95.8084% (minimum 99%, Missing); retina: 96.9697% (minimum 99%, Missing); spinal cord: 96.6767% (minimum 99%, Missing)",0.05,0.03,-0.0319162,0,1,partial,2.3,0.9,1.8,"pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163806,SPDYA,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.208084,0,1,partial,2.3,0.9,1.8,"pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163806,SPDYA,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.208084,0,1,partial,2.3,0.9,1.8,"pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163806,SPDYA,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.208084,0,1,partial,2.3,0.9,1.8,"pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163806,SPDYA,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.296746,0.272644,0.182945,0,1,partial,2.3,0.9,1.8,"cerebellum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163806,SPDYA,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.6111% (minimum 99%, Missing); basal ganglia: 98.6111% (minimum 99%, Missing); bone marrow: 58.1967% (minimum 99%, Missing); cerebral cortex: 95.9459% (minimum 99%, Missing); colon: 83.5294% (minimum 97%, Missing); duodenum: 84.5238% (minimum 99%, Missing); esophagus: 86.5854% (minimum 95%, Approved); hippocampal formation: 98.6111% (minimum 99%, Missing); lung: 97.2603% (minimum 98%, Approved); lymph node: 76.3441% (minimum 97%, Missing); midbrain: 98.6111% (minimum 99%, Missing); rectum: 82.5581% (minimum 97%, Missing); retina: 98.6111% (minimum 99%, Missing); skin: 89.8734% (minimum 90%, Approved); small intestine: 83.5294% (minimum 99%, Missing); smooth muscle: 94.6667% (minimum 99%, Missing); spleen: 94.6667% (minimum 95%, Missing); stomach: 89.8734% (minimum 97%, Missing); thymus: 44.0994% (minimum 95%, Missing); urinary bladder: 95.9459% (minimum 97%, Missing)",-0.509006,-0.206559,-0.408033,0,5,partial,5.1,2.2,9,"thymus: 9 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thymus / cortical cells: High (Approved); thymus / medullary cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163808,KIF15,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 58.1967% (minimum 75%, Missing); thymus: 44.0994% (minimum 65%, Missing)",-0.209006,0.0634409,-0.168033,0,5,partial,5.1,2.2,9,"thymus: 9 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thymus / cortical cells: High (Approved); thymus / medullary cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163808,KIF15,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 58.1967% (minimum 75%, Missing); thymus: 44.0994% (minimum 65%, Missing)",-0.209006,0.0634409,-0.168033,0,5,partial,5.1,2.2,9,"thymus: 9 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thymus / cortical cells: High (Approved); thymus / medullary cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163808,KIF15,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 58.1967% (minimum 75%, Missing); thymus: 44.0994% (minimum 65%, Missing)",-0.209006,0.0634409,-0.168033,0,5,partial,5.1,2.2,9,"thymus: 9 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thymus / cortical cells: High (Approved); thymus / medullary cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163808,KIF15,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 58.1967% (minimum 75%, Baseline (adaptation disabled)); thymus: 44.0994% (minimum 65%, Baseline (adaptation disabled))",-0.209006,0.0634409,-0.168033,0,5,partial,5.1,2.2,9,"thymus: 9 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thymus / cortical cells: High (Approved); thymus / medullary cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163808,KIF15,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 95%, Missing); adrenal gland: 55.7576% (minimum 99%, Missing); amygdala: 79.3103% (minimum 99%, Missing); basal ganglia: 75.4098% (minimum 99%, Missing); bone marrow: 37.5510% (minimum 99%, Missing); cerebellum: 62.1622% (minimum 99%, Missing); cerebral cortex: 64.3357% (minimum 99%, Missing); choroid plexus: 80.7018% (minimum 99%, Missing); colon: 60.5263% (minimum 97%, Missing); duodenum: 59.7403% (minimum 99%, Missing); esophagus: 57.8616% (minimum 97%, Missing); heart muscle: 58.5987% (minimum 99%, Missing); hippocampal formation: 79.3103% (minimum 99%, Missing); hypothalamus: 76.6667% (minimum 99%, Missing); kidney: 58.5987% (minimum 99%, Missing); liver: 67.1533% (minimum 99%, Missing); lung: 59.7403% (minimum 99%, Missing); lymph node: 49.7297% (minimum 97%, Missing); midbrain: 79.3103% (minimum 99%, Missing); pancreas: 65.7143% (minimum 99%, Missing); parathyroid gland: 55.7576% (minimum 97%, Missing); pituitary gland: 57.8616% (minimum 99%, Missing); rectum: 56.0976% (minimum 97%, Missing); retina: 50.5495% (minimum 99%, Missing); salivary gland: 64.7887% (minimum 97%, Missing); skeletal muscle: 73.0159% (minimum 99%, Missing); skin: 53.4884% (minimum 95%, Missing); small intestine: 57.1429% (minimum 99%, Missing); smooth muscle: 59.3548% (minimum 99%, Missing); spinal cord: 74.1935% (minimum 99%, Missing); spleen: 47.1795% (minimum 95%, Missing); stomach: 56.7901% (minimum 97%, Missing); thymus: 53.8012% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 67.1533% (minimum 97%, Missing); urinary bladder: 63.4483% (minimum 97%, Missing)",-0.478205,-0.472703,-0.61449,0,2,partial,15.3,9.3,10.3,"bone marrow: 15.3 nTPM (vital, limit 1); spleen: 10.3 nTPM (manageable, limit 5); lymph node: 9.3 nTPM (protected, limit 2); thyroid gland: 9.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 2); adrenal gland: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 2); cerebral cortex: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163867,ZMYM6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 65%, Missing); adrenal gland: 55.7576% (minimum 75%, Missing); bone marrow: 37.5510% (minimum 75%, Missing); cerebellum: 62.1622% (minimum 75%, Missing); cerebral cortex: 64.3357% (minimum 75%, Missing); colon: 60.5263% (minimum 70%, Missing); duodenum: 59.7403% (minimum 75%, Missing); esophagus: 57.8616% (minimum 70%, Missing); heart muscle: 58.5987% (minimum 75%, Missing); kidney: 58.5987% (minimum 75%, Missing); liver: 67.1533% (minimum 75%, Missing); lung: 59.7403% (minimum 75%, Missing); lymph node: 49.7297% (minimum 70%, Missing); pancreas: 65.7143% (minimum 75%, Missing); parathyroid gland: 55.7576% (minimum 70%, Missing); pituitary gland: 57.8616% (minimum 75%, Missing); rectum: 56.0976% (minimum 70%, Missing); retina: 50.5495% (minimum 75%, Missing); salivary gland: 64.7887% (minimum 70%, Missing); skeletal muscle: 73.0159% (minimum 75%, Missing); skin: 53.4884% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); smooth muscle: 59.3548% (minimum 75%, Missing); spinal cord: 74.1935% (minimum 75%, Missing); spleen: 47.1795% (minimum 65%, Missing); stomach: 56.7901% (minimum 70%, Missing); thymus: 53.8012% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 67.1533% (minimum 70%, Missing); urinary bladder: 63.4483% (minimum 70%, Missing)",-0.178205,-0.202703,-0.37449,0,2,partial,15.3,9.3,10.3,"bone marrow: 15.3 nTPM (vital, limit 1); spleen: 10.3 nTPM (manageable, limit 5); lymph node: 9.3 nTPM (protected, limit 2); thyroid gland: 9.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 2); adrenal gland: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 2); cerebral cortex: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163867,ZMYM6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 65%, Missing); adrenal gland: 55.7576% (minimum 75%, Missing); bone marrow: 37.5510% (minimum 75%, Missing); cerebellum: 62.1622% (minimum 75%, Missing); cerebral cortex: 64.3357% (minimum 75%, Missing); colon: 60.5263% (minimum 70%, Missing); duodenum: 59.7403% (minimum 75%, Missing); esophagus: 57.8616% (minimum 70%, Missing); heart muscle: 58.5987% (minimum 75%, Missing); kidney: 58.5987% (minimum 75%, Missing); liver: 67.1533% (minimum 75%, Missing); lung: 59.7403% (minimum 75%, Missing); lymph node: 49.7297% (minimum 70%, Missing); pancreas: 65.7143% (minimum 75%, Missing); parathyroid gland: 55.7576% (minimum 70%, Missing); pituitary gland: 57.8616% (minimum 75%, Missing); rectum: 56.0976% (minimum 70%, Missing); retina: 50.5495% (minimum 75%, Missing); salivary gland: 64.7887% (minimum 70%, Missing); skeletal muscle: 73.0159% (minimum 75%, Missing); skin: 53.4884% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); smooth muscle: 59.3548% (minimum 75%, Missing); spinal cord: 74.1935% (minimum 75%, Missing); spleen: 47.1795% (minimum 65%, Missing); stomach: 56.7901% (minimum 70%, Missing); thymus: 53.8012% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 67.1533% (minimum 70%, Missing); urinary bladder: 63.4483% (minimum 70%, Missing)",-0.178205,-0.202703,-0.37449,0,2,partial,15.3,9.3,10.3,"bone marrow: 15.3 nTPM (vital, limit 1); spleen: 10.3 nTPM (manageable, limit 5); lymph node: 9.3 nTPM (protected, limit 3); thyroid gland: 9.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 3); adrenal gland: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 3); cerebral cortex: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163867,ZMYM6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 65%, Missing); adrenal gland: 55.7576% (minimum 75%, Missing); bone marrow: 37.5510% (minimum 75%, Missing); cerebellum: 62.1622% (minimum 75%, Missing); cerebral cortex: 64.3357% (minimum 75%, Missing); colon: 60.5263% (minimum 70%, Missing); duodenum: 59.7403% (minimum 75%, Missing); esophagus: 57.8616% (minimum 70%, Missing); heart muscle: 58.5987% (minimum 75%, Missing); kidney: 58.5987% (minimum 75%, Missing); liver: 67.1533% (minimum 75%, Missing); lung: 59.7403% (minimum 75%, Missing); lymph node: 49.7297% (minimum 70%, Missing); pancreas: 65.7143% (minimum 75%, Missing); parathyroid gland: 55.7576% (minimum 70%, Missing); pituitary gland: 57.8616% (minimum 75%, Missing); rectum: 56.0976% (minimum 70%, Missing); retina: 50.5495% (minimum 75%, Missing); salivary gland: 64.7887% (minimum 70%, Missing); skeletal muscle: 73.0159% (minimum 75%, Missing); skin: 53.4884% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); smooth muscle: 59.3548% (minimum 75%, Missing); spinal cord: 74.1935% (minimum 75%, Missing); spleen: 47.1795% (minimum 65%, Missing); stomach: 56.7901% (minimum 70%, Missing); thymus: 53.8012% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 67.1533% (minimum 70%, Missing); urinary bladder: 63.4483% (minimum 70%, Missing)",-0.178205,-0.202703,-0.37449,0,2,partial,15.3,9.3,10.3,"bone marrow: 15.3 nTPM (vital, limit 1); spleen: 10.3 nTPM (manageable, limit 5); lymph node: 9.3 nTPM (protected, limit 3); thyroid gland: 9.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 3); adrenal gland: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 3); cerebral cortex: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163867,ZMYM6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 55.7576% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 37.5510% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.1622% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.3357% (minimum 75%, Baseline (adaptation disabled)); colon: 60.5263% (minimum 70%, Baseline (adaptation disabled)); duodenum: 59.7403% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.8616% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.5987% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.5987% (minimum 75%, Baseline (adaptation disabled)); liver: 67.1533% (minimum 75%, Baseline (adaptation disabled)); lung: 59.7403% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.7297% (minimum 70%, Baseline (adaptation disabled)); pancreas: 65.7143% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.7576% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 57.8616% (minimum 75%, Baseline (adaptation disabled)); rectum: 56.0976% (minimum 70%, Baseline (adaptation disabled)); retina: 50.5495% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.7887% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 73.0159% (minimum 75%, Baseline (adaptation disabled)); skin: 53.4884% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.1429% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.3548% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.1935% (minimum 75%, Baseline (adaptation disabled)); spleen: 47.1795% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.7901% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.8012% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.1533% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.4483% (minimum 70%, Baseline (adaptation disabled))",-0.178205,-0.202703,-0.37449,0,2,partial,15.3,9.3,10.3,"bone marrow: 15.3 nTPM (vital, limit 1); spleen: 10.3 nTPM (manageable, limit 5); lymph node: 9.3 nTPM (protected, limit 3); thyroid gland: 9.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 3); adrenal gland: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 3); cerebral cortex: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163867,ZMYM6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 89.9317% (minimum 95%, Enhanced); amygdala: 83.5182% (minimum 99%, Missing); basal ganglia: 80.7044% (minimum 99%, Missing); cerebellum: 94.6140% (minimum 95%, Enhanced); cerebral cortex: 87.5415% (minimum 95%, Enhanced); choroid plexus: 40.6009% (minimum 99%, Missing); colon: 91.1765% (minimum 97%, Missing); duodenum: 97.7737% (minimum 99%, Missing); heart muscle: 94.1071% (minimum 95%, Enhanced); hippocampal formation: 82.3438% (minimum 99%, Missing); hypothalamus: 77.1596% (minimum 99%, Missing); kidney: 81.7054% (minimum 95%, Enhanced); liver: 81.8323% (minimum 95%, Enhanced); lung: 83.9172% (minimum 95%, Enhanced); midbrain: 82.3438% (minimum 99%, Missing); pancreas: 85.5519% (minimum 95%, Enhanced); pituitary gland: 81.0769% (minimum 99%, Missing); rectum: 95.9927% (minimum 97%, Missing); retina: 82.0872% (minimum 99%, Missing); salivary gland: 92.2942% (minimum 97%, Missing); small intestine: 95.9927% (minimum 99%, Missing); smooth muscle: 92.9453% (minimum 95%, Enhanced); spinal cord: 82.3438% (minimum 99%, Missing); stomach: 89.4737% (minimum 97%, Missing)",0.0368914,-0.0752632,-0.583991,0,10,partial,77.1,8.8,10.3,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 6); liver: 11.7 nTPM (vital, limit 6); retina: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 6); pancreas: 8.9 nTPM (vital, limit 6); cerebral cortex: 7.5 nTPM (vital, limit 6); stomach: 6.2 nTPM (protected, limit 2); colon: 5.1 nTPM (protected, limit 2); salivary gland: 4.4 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); salivary gland / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Gradient; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163879,DNALI1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 40.6009% (minimum 75%, Missing)",0.336508,0.194737,-0.343991,0,10,partial,77.1,8.8,10.3,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 6); liver: 11.7 nTPM (vital, limit 6); retina: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 6); pancreas: 8.9 nTPM (vital, limit 6); cerebral cortex: 7.5 nTPM (vital, limit 6); stomach: 6.2 nTPM (protected, limit 2); colon: 5.1 nTPM (protected, limit 2); salivary gland: 4.4 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); salivary gland / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Gradient; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163879,DNALI1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 40.6009% (minimum 75%, Missing)",0.336508,0.194737,-0.343991,0,10,partial,77.1,8.8,10.3,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 6); liver: 11.7 nTPM (vital, limit 6); retina: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 6); pancreas: 8.9 nTPM (vital, limit 6); cerebral cortex: 7.5 nTPM (vital, limit 6); stomach: 6.2 nTPM (protected, limit 3); colon: 5.1 nTPM (protected, limit 3); salivary gland: 4.4 nTPM (protected, limit 3); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); salivary gland / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Gradient; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163879,DNALI1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 40.6009% (minimum 75%, Missing)",0.336508,0.194737,-0.343991,0,10,partial,77.1,8.8,10.3,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 6); liver: 11.7 nTPM (vital, limit 6); retina: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 6); pancreas: 8.9 nTPM (vital, limit 6); cerebral cortex: 7.5 nTPM (vital, limit 6); stomach: 6.2 nTPM (protected, limit 3); colon: 5.1 nTPM (protected, limit 3); salivary gland: 4.4 nTPM (protected, limit 3); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); salivary gland / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Gradient; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163879,DNALI1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 40.6009% (minimum 75%, Baseline (adaptation disabled))",0.186508,0.156911,-0.343991,0,10,partial,77.1,8.8,10.3,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 1); liver: 11.7 nTPM (vital, limit 1); retina: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); pancreas: 8.9 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 3); cerebral cortex: 7.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 3); adrenal gland: 5.9 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); salivary gland: 4.4 nTPM (protected, limit 3); smooth muscle: 4 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); heart muscle: 3.3 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); salivary gland / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Gradient; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163879,DNALI1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.1662% (minimum 99%, Missing); basal ganglia: 89.7436% (minimum 99%, Missing); choroid plexus: 70.7865% (minimum 99%, Missing); hippocampal formation: 91.0405% (minimum 99%, Missing); hypothalamus: 90.2579% (minimum 99%, Missing); lung: 84.0000% (minimum 95%, Enhanced); midbrain: 98.4375% (minimum 99%, Missing); spinal cord: 98.4375% (minimum 99%, Missing)",0.05,0.03,-0.282135,0,4,partial,13,0.1,0.1,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163885,CFAP100,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 70.7865% (minimum 75%, Missing)",0.35,0.3,-0.0421348,0,4,partial,13,0.1,0.1,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163885,CFAP100,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 70.7865% (minimum 75%, Missing)",0.35,0.3,-0.0421348,0,4,partial,13,0.1,0.1,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163885,CFAP100,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 70.7865% (minimum 75%, Missing)",0.35,0.3,-0.0421348,0,4,partial,13,0.1,0.1,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163885,CFAP100,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 70.7865% (minimum 75%, Baseline (adaptation disabled))",0.346835,0.296835,-0.0421348,0,4,partial,13,0.1,0.1,"choroid plexus: 13 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163885,CFAP100,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 94.5933% (minimum 99%, Missing); basal ganglia: 94.8124% (minimum 99%, Missing); bone marrow: 91.4656% (minimum 98%, Approved); cerebral cortex: 95.0325% (minimum 98%, Approved); choroid plexus: 96.8765% (minimum 99%, Missing); colon: 94.4188% (minimum 97%, Missing); duodenum: 98.4135% (minimum 99%, Missing); heart muscle: 94.8124% (minimum 99%, Missing); hippocampal formation: 95.5203% (minimum 99%, Missing); hypothalamus: 95.5649% (minimum 99%, Missing); kidney: 96.8307% (minimum 99%, Missing); liver: 97.8957% (minimum 99%, Missing); lung: 97.4762% (minimum 98%, Approved); lymph node: 94.0717% (minimum 95%, Approved); midbrain: 95.6989% (minimum 99%, Missing); pancreas: 91.1804% (minimum 98%, Approved); pituitary gland: 97.8022% (minimum 99%, Missing); retina: 96.5566% (minimum 99%, Missing); salivary gland: 96.1936% (minimum 97%, Missing); skeletal muscle: 98.9845% (minimum 99%, Missing); small intestine: 97.1523% (minimum 99%, Missing); smooth muscle: 96.2841% (minimum 98%, Approved); spinal cord: 95.8333% (minimum 99%, Missing); thymus: 92.7083% (minimum 95%, Missing)",-0.0229167,-0.0258118,-0.068196,0,4,partial,19.8,12.9,16.1,"pancreas: 19.8 nTPM (vital, limit 2); bone marrow: 19.1 nTPM (vital, limit 2); thymus: 16.1 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 4); colon: 12.1 nTPM (protected, limit 2); amygdala: 11.7 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 10); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 4); urinary bladder: 8.2 nTPM (protected, limit 4); salivary gland: 8.1 nTPM (protected, limit 2); smooth muscle: 7.9 nTPM (vital, limit 2); retina: 7.3 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 4); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 4); lung: 5.3 nTPM (vital, limit 2); pituitary gland: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 2); tongue: 2.2 nTPM (protected, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163923,RPL39L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277083,0.244188,0.195933,0,4,partial,19.8,12.9,16.1,"pancreas: 19.8 nTPM (vital, limit 2); bone marrow: 19.1 nTPM (vital, limit 2); thymus: 16.1 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 4); colon: 12.1 nTPM (protected, limit 2); amygdala: 11.7 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 10); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 4); urinary bladder: 8.2 nTPM (protected, limit 4); salivary gland: 8.1 nTPM (protected, limit 2); smooth muscle: 7.9 nTPM (vital, limit 2); retina: 7.3 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 4); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 4); lung: 5.3 nTPM (vital, limit 2); pituitary gland: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 2); tongue: 2.2 nTPM (protected, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163923,RPL39L,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277083,0.244188,0.195933,0,4,partial,19.8,12.9,16.1,"pancreas: 19.8 nTPM (vital, limit 2); bone marrow: 19.1 nTPM (vital, limit 2); thymus: 16.1 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 4); colon: 12.1 nTPM (protected, limit 3); amygdala: 11.7 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 10); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 4); urinary bladder: 8.2 nTPM (protected, limit 4); salivary gland: 8.1 nTPM (protected, limit 3); smooth muscle: 7.9 nTPM (vital, limit 2); retina: 7.3 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 4); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 4); lung: 5.3 nTPM (vital, limit 2); pituitary gland: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163923,RPL39L,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277083,0.244188,0.195933,0,4,partial,19.8,12.9,16.1,"pancreas: 19.8 nTPM (vital, limit 2); bone marrow: 19.1 nTPM (vital, limit 2); thymus: 16.1 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 4); colon: 12.1 nTPM (protected, limit 3); amygdala: 11.7 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 10); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 4); urinary bladder: 8.2 nTPM (protected, limit 4); salivary gland: 8.1 nTPM (protected, limit 3); smooth muscle: 7.9 nTPM (vital, limit 2); retina: 7.3 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 4); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 4); lung: 5.3 nTPM (vital, limit 2); pituitary gland: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163923,RPL39L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277083,0.240717,0.161804,0,4,partial,19.8,12.9,16.1,"pancreas: 19.8 nTPM (vital, limit 1); bone marrow: 19.1 nTPM (vital, limit 1); thymus: 16.1 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 3); colon: 12.1 nTPM (protected, limit 3); amygdala: 11.7 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 3); urinary bladder: 8.2 nTPM (protected, limit 3); salivary gland: 8.1 nTPM (protected, limit 3); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.5 nTPM (manageable, limit 5); retina: 7.3 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); choroid plexus: 6.6 nTPM (vital, limit 1); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 3); lung: 5.3 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163923,RPL39L,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.3838% (minimum 99%, Missing); liver: 98.7830% (minimum 99%, Missing)",0.0201195,0.03,-0.00616162,0,80,unavailable,0.8,0,1.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163958,ZDHHC19,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.32012,0.3,0.233838,0,80,unavailable,0.8,0,1.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163958,ZDHHC19,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.32012,0.3,0.233838,0,80,unavailable,0.8,0,1.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163958,ZDHHC19,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.32012,0.3,0.233838,0,80,unavailable,0.8,0,1.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163958,ZDHHC19,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.32012,0.3,0.233838,0,80,unavailable,0.8,0,1.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000163958,ZDHHC19,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8039% (minimum 95%, Missing); adrenal gland: 80.7947% (minimum 99%, Missing); amygdala: 91.7293% (minimum 99%, Missing); basal ganglia: 87.7698% (minimum 99%, Missing); bone marrow: 73.0539% (minimum 99%, Missing); cerebellum: 93.8462% (minimum 99%, Missing); cerebral cortex: 79.2208% (minimum 99%, Missing); choroid plexus: 43.8849% (minimum 99%, Missing); colon: 50.6224% (minimum 97%, Missing); duodenum: 39.2283% (minimum 99%, Missing); esophagus: 43.5714% (minimum 90%, Supported); heart muscle: 58.0952% (minimum 99%, Missing); hippocampal formation: 88.4058% (minimum 99%, Missing); hypothalamus: 88.4058% (minimum 99%, Missing); kidney: 46.7433% (minimum 99%, Missing); liver: 38.3648% (minimum 99%, Missing); lung: 31.4433% (minimum 99%, Missing); lymph node: 91.7293% (minimum 97%, Missing); midbrain: 86.5248% (minimum 99%, Missing); pancreas: 51.9149% (minimum 99%, Missing); parathyroid gland: 77.7070% (minimum 97%, Missing); pituitary gland: 73.0539% (minimum 99%, Missing); rectum: 54.4643% (minimum 97%, Missing); retina: 93.8462% (minimum 99%, Missing); salivary gland: 57.5472% (minimum 97%, Missing); skeletal muscle: 83.5616% (minimum 99%, Missing); skin: 77.7070% (minimum 95%, Missing); small intestine: 43.8849% (minimum 99%, Missing); smooth muscle: 30.5764% (minimum 99%, Missing); spinal cord: 78.7097% (minimum 99%, Missing); spleen: 92.4242% (minimum 95%, Missing); stomach: 47.6562% (minimum 97%, Missing); thymus: 93.8462% (minimum 95%, Missing); thyroid gland: 41.0774% (minimum 95%, Missing); tongue: 78.7097% (minimum 97%, Missing); urinary bladder: 47.6562% (minimum 97%, Missing)",-0.539226,-0.493438,-0.684236,0,16,partial,27.7,15.8,17.5,"smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 6); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); urinary bladder: 13.4 nTPM (protected, limit 2); colon: 11.9 nTPM (protected, limit 2); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 2); salivary gland: 9 nTPM (protected, limit 2); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / enterocytes - Microvilli; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164023,SGMS2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8039% (minimum 65%, Missing); bone marrow: 73.0539% (minimum 75%, Missing); choroid plexus: 43.8849% (minimum 75%, Missing); colon: 50.6224% (minimum 70%, Missing); duodenum: 39.2283% (minimum 75%, Missing); esophagus: 43.5714% (minimum 60%, Supported); heart muscle: 58.0952% (minimum 75%, Missing); kidney: 46.7433% (minimum 75%, Missing); liver: 38.3648% (minimum 75%, Missing); lung: 31.4433% (minimum 75%, Missing); pancreas: 51.9149% (minimum 75%, Missing); pituitary gland: 73.0539% (minimum 75%, Missing); rectum: 54.4643% (minimum 70%, Missing); salivary gland: 57.5472% (minimum 70%, Missing); small intestine: 43.8849% (minimum 75%, Missing); smooth muscle: 30.5764% (minimum 75%, Missing); stomach: 47.6562% (minimum 70%, Missing); thyroid gland: 41.0774% (minimum 65%, Missing); urinary bladder: 47.6562% (minimum 70%, Missing)",-0.239226,-0.223438,-0.444236,0,16,partial,27.7,15.8,17.5,"smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 6); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); urinary bladder: 13.4 nTPM (protected, limit 2); colon: 11.9 nTPM (protected, limit 2); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 2); salivary gland: 9 nTPM (protected, limit 2); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / enterocytes - Microvilli; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164023,SGMS2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8039% (minimum 65%, Missing); bone marrow: 73.0539% (minimum 75%, Missing); choroid plexus: 43.8849% (minimum 75%, Missing); colon: 50.6224% (minimum 70%, Missing); duodenum: 39.2283% (minimum 75%, Missing); esophagus: 43.5714% (minimum 60%, Supported); heart muscle: 58.0952% (minimum 75%, Missing); kidney: 46.7433% (minimum 75%, Missing); liver: 38.3648% (minimum 75%, Missing); lung: 31.4433% (minimum 75%, Missing); pancreas: 51.9149% (minimum 75%, Missing); pituitary gland: 73.0539% (minimum 75%, Missing); rectum: 54.4643% (minimum 70%, Missing); salivary gland: 57.5472% (minimum 70%, Missing); small intestine: 43.8849% (minimum 75%, Missing); smooth muscle: 30.5764% (minimum 75%, Missing); stomach: 47.6562% (minimum 70%, Missing); thyroid gland: 41.0774% (minimum 65%, Missing); urinary bladder: 47.6562% (minimum 70%, Missing)",-0.239226,-0.223438,-0.444236,0,16,partial,27.7,15.8,17.5,"smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 6); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); urinary bladder: 13.4 nTPM (protected, limit 3); colon: 11.9 nTPM (protected, limit 3); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 3); salivary gland: 9 nTPM (protected, limit 3); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / enterocytes - Microvilli; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164023,SGMS2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8039% (minimum 65%, Missing); bone marrow: 73.0539% (minimum 75%, Missing); choroid plexus: 43.8849% (minimum 75%, Missing); colon: 50.6224% (minimum 70%, Missing); duodenum: 39.2283% (minimum 75%, Missing); esophagus: 43.5714% (minimum 60%, Supported); heart muscle: 58.0952% (minimum 75%, Missing); kidney: 46.7433% (minimum 75%, Missing); liver: 38.3648% (minimum 75%, Missing); lung: 31.4433% (minimum 75%, Missing); pancreas: 51.9149% (minimum 75%, Missing); pituitary gland: 73.0539% (minimum 75%, Missing); rectum: 54.4643% (minimum 70%, Missing); salivary gland: 57.5472% (minimum 70%, Missing); small intestine: 43.8849% (minimum 75%, Missing); smooth muscle: 30.5764% (minimum 75%, Missing); stomach: 47.6562% (minimum 70%, Missing); thyroid gland: 41.0774% (minimum 65%, Missing); urinary bladder: 47.6562% (minimum 70%, Missing)",-0.239226,-0.223438,-0.444236,0,16,partial,27.7,15.8,17.5,"smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 6); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); urinary bladder: 13.4 nTPM (protected, limit 3); colon: 11.9 nTPM (protected, limit 3); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 3); salivary gland: 9 nTPM (protected, limit 3); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / enterocytes - Microvilli; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164023,SGMS2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8039% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 73.0539% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 43.8849% (minimum 75%, Baseline (adaptation disabled)); colon: 50.6224% (minimum 70%, Baseline (adaptation disabled)); duodenum: 39.2283% (minimum 75%, Baseline (adaptation disabled)); esophagus: 43.5714% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.0952% (minimum 75%, Baseline (adaptation disabled)); kidney: 46.7433% (minimum 75%, Baseline (adaptation disabled)); liver: 38.3648% (minimum 75%, Baseline (adaptation disabled)); lung: 31.4433% (minimum 75%, Baseline (adaptation disabled)); pancreas: 51.9149% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 73.0539% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.4643% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 57.5472% (minimum 70%, Baseline (adaptation disabled)); small intestine: 43.8849% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 30.5764% (minimum 75%, Baseline (adaptation disabled)); stomach: 47.6562% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 41.0774% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 47.6562% (minimum 70%, Baseline (adaptation disabled))",-0.239226,-0.264286,-0.444236,0,16,partial,27.7,15.8,17.5,"smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 3); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); urinary bladder: 13.4 nTPM (protected, limit 3); colon: 11.9 nTPM (protected, limit 3); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 3); salivary gland: 9 nTPM (protected, limit 3); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / enterocytes - Microvilli; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164023,SGMS2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.0000% (minimum 99%, Missing); bone marrow: 98.4925% (minimum 99%, Missing); cerebral cortex: 97.5124% (minimum 99%, Missing); choroid plexus: 98.2456% (minimum 99%, Missing); duodenum: 98.2456% (minimum 99%, Missing); heart muscle: 98.0000% (minimum 99%, Missing); hippocampal formation: 98.9899% (minimum 99%, Missing); kidney: 98.7406% (minimum 99%, Missing); lung: 98.7406% (minimum 99%, Missing); midbrain: 98.7406% (minimum 99%, Missing); pancreas: 97.0297% (minimum 99%, Missing); pituitary gland: 98.7406% (minimum 99%, Missing); retina: 95.8435% (minimum 99%, Missing); small intestine: 98.7406% (minimum 99%, Missing); smooth muscle: 98.4925% (minimum 99%, Missing); spinal cord: 98.0000% (minimum 99%, Missing)",0.00609756,0.00755611,-0.0315648,0,80,unavailable,1.7,0.9,1.8,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164037,SLC9B1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.306098,0.277556,0.208435,0,80,unavailable,1.7,0.9,1.8,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164037,SLC9B1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.306098,0.277556,0.208435,0,80,unavailable,1.7,0.9,1.8,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164037,SLC9B1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.306098,0.277556,0.208435,0,80,unavailable,1.7,0.9,1.8,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164037,SLC9B1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.306098,0.277556,0.208435,0,80,unavailable,1.7,0.9,1.8,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164037,SLC9B1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.4783% (minimum 99%, Missing); amygdala: 95.5556% (minimum 99%, Missing); basal ganglia: 95.5556% (minimum 99%, Missing); bone marrow: 46.0714% (minimum 99%, Missing); cerebellum: 96.9925% (minimum 99%, Missing); cerebral cortex: 95.5556% (minimum 99%, Missing); choroid plexus: 97.7273% (minimum 99%, Missing); colon: 79.1411% (minimum 97%, Missing); duodenum: 86.5772% (minimum 99%, Missing); esophagus: 84.8684% (minimum 97%, Missing); heart muscle: 96.9925% (minimum 99%, Missing); hippocampal formation: 96.9925% (minimum 99%, Missing); hypothalamus: 90.8451% (minimum 99%, Missing); kidney: 95.5556% (minimum 99%, Missing); liver: 94.8529% (minimum 99%, Missing); lung: 97.7273% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 94.1606% (minimum 99%, Missing); pancreas: 94.8529% (minimum 99%, Missing); parathyroid gland: 94.8529% (minimum 97%, Missing); pituitary gland: 94.8529% (minimum 99%, Missing); rectum: 77.2455% (minimum 97%, Missing); retina: 87.1622% (minimum 99%, Missing); salivary gland: 94.8529% (minimum 97%, Missing); skeletal muscle: 96.9925% (minimum 99%, Missing); small intestine: 87.7551% (minimum 99%, Missing); smooth muscle: 92.8058% (minimum 99%, Missing); spinal cord: 98.4733% (minimum 99%, Missing); spleen: 87.1622% (minimum 95%, Missing); stomach: 93.4783% (minimum 97%, Missing); thymus: 60.0000% (minimum 95%, Missing); thyroid gland: 88.3562% (minimum 95%, Missing); urinary bladder: 93.4783% (minimum 97%, Missing)",-0.35,-0.22,-0.529286,0,80,unavailable,15.1,4.3,8.6,"bone marrow: 15.1 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164045,CDC25A,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 46.0714% (minimum 75%, Missing); thymus: 60.0000% (minimum 65%, Missing)",-0.05,0.05,-0.289286,0,80,unavailable,15.1,4.3,8.6,"bone marrow: 15.1 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164045,CDC25A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 46.0714% (minimum 75%, Missing); thymus: 60.0000% (minimum 65%, Missing)",-0.05,0.05,-0.289286,0,80,unavailable,15.1,4.3,8.6,"bone marrow: 15.1 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); rectum: 3.8 nTPM (protected, limit 3); colon: 3.4 nTPM (protected, limit 3); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164045,CDC25A,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 46.0714% (minimum 75%, Missing); thymus: 60.0000% (minimum 65%, Missing)",-0.05,0.05,-0.289286,0,80,unavailable,15.1,4.3,8.6,"bone marrow: 15.1 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); rectum: 3.8 nTPM (protected, limit 3); colon: 3.4 nTPM (protected, limit 3); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164045,CDC25A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 46.0714% (minimum 75%, Baseline (adaptation disabled)); thymus: 60.0000% (minimum 65%, Baseline (adaptation disabled))",-0.05,0.05,-0.289286,0,80,unavailable,15.1,4.3,8.6,"bone marrow: 15.1 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); rectum: 3.8 nTPM (protected, limit 3); colon: 3.4 nTPM (protected, limit 3); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164045,CDC25A,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.6438% (minimum 95%, Enhanced); amygdala: 95.7389% (minimum 99%, Missing); basal ganglia: 95.0495% (minimum 99%, Missing); cerebellum: 92.7129% (minimum 99%, Missing); cerebral cortex: 92.7944% (minimum 95%, Enhanced); choroid plexus: 92.8760% (minimum 99%, Missing); heart muscle: 94.4544% (minimum 95%, Enhanced); hippocampal formation: 96.0000% (minimum 99%, Missing); hypothalamus: 91.8261% (minimum 99%, Missing); kidney: 89.1139% (minimum 95%, Enhanced); liver: 93.6170% (minimum 95%, Enhanced); lung: 98.5994% (minimum 99%, Missing); midbrain: 94.5389% (minimum 99%, Missing); pituitary gland: 93.1217% (minimum 99%, Missing); retina: 80.1822% (minimum 99%, Missing); spinal cord: 97.1481% (minimum 99%, Missing); tongue: 96.8807% (minimum 97%, Missing)",0.0143836,-0.00119266,-0.188178,0,5,partial,26.1,13.3,8.2,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 12); kidney: 12.9 nTPM (vital, limit 6); adrenal gland: 10.9 nTPM (vital, limit 6); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); cerebral cortex: 8.2 nTPM (vital, limit 6); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 6); heart muscle: 6.2 nTPM (vital, limit 6); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); spinal cord: 3.1 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164070,HSPA4L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.314384,0.268807,0.0518223,0,5,partial,26.1,13.3,8.2,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 12); kidney: 12.9 nTPM (vital, limit 6); adrenal gland: 10.9 nTPM (vital, limit 6); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); cerebral cortex: 8.2 nTPM (vital, limit 6); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 6); heart muscle: 6.2 nTPM (vital, limit 6); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); spinal cord: 3.1 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164070,HSPA4L,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.314384,0.268807,0.0518223,0,5,partial,26.1,13.3,8.2,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 12); kidney: 12.9 nTPM (vital, limit 6); adrenal gland: 10.9 nTPM (vital, limit 6); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); cerebral cortex: 8.2 nTPM (vital, limit 6); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 6); heart muscle: 6.2 nTPM (vital, limit 6); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164070,HSPA4L,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.314384,0.268807,0.0518223,0,5,partial,26.1,13.3,8.2,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 12); kidney: 12.9 nTPM (vital, limit 6); adrenal gland: 10.9 nTPM (vital, limit 6); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); cerebral cortex: 8.2 nTPM (vital, limit 6); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 6); heart muscle: 6.2 nTPM (vital, limit 6); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164070,HSPA4L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277944,0.188141,0.0518223,0,5,partial,26.1,13.3,8.2,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 3); kidney: 12.9 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 3); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); cerebral cortex: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164070,HSPA4L,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.0482729,0.03,0.01,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164113,ADAD1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348273,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164113,ADAD1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348273,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164113,ADAD1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348273,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164113,ADAD1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348273,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164113,ADAD1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 95.3704% (minimum 99%, Missing); retina: 98.0952% (minimum 99%, Missing)",0.0403846,0.03,-0.0362963,0,80,unavailable,0.5,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164123,SPMIP2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340385,0.3,0.203704,0,80,unavailable,0.5,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164123,SPMIP2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340385,0.3,0.203704,0,80,unavailable,0.5,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164123,SPMIP2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340385,0.3,0.203704,0,80,unavailable,0.5,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164123,SPMIP2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340385,0.3,0.203704,0,80,unavailable,0.5,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164123,SPMIP2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.9091% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 99%, Missing); colon: 83.3333% (minimum 97%, Missing); heart muscle: 76.9231% (minimum 99%, Missing); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 83.3333% (minimum 99%, Missing); kidney: 71.4286% (minimum 99%, Missing); liver: 45.4545% (minimum 99%, Missing); midbrain: 90.9091% (minimum 99%, Missing); pituitary gland: 90.9091% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 71.4286% (minimum 99%, Missing); skeletal muscle: 90.9091% (minimum 99%, Missing); skin: 50.0000% (minimum 95%, Missing); spinal cord: 83.3333% (minimum 99%, Missing); stomach: 83.3333% (minimum 97%, Missing); tongue: 90.9091% (minimum 97%, Missing)",-0.45,-0.136667,-0.535455,0,80,unavailable,1.2,0.2,1,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164175,SLC45A2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 71.4286% (minimum 75%, Missing); liver: 45.4545% (minimum 75%, Missing); retina: 71.4286% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing)",-0.15,0.133333,-0.295455,0,80,unavailable,1.2,0.2,1,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164175,SLC45A2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 71.4286% (minimum 75%, Missing); liver: 45.4545% (minimum 75%, Missing); retina: 71.4286% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing)",-0.15,0.133333,-0.295455,0,80,unavailable,1.2,0.2,1,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164175,SLC45A2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 71.4286% (minimum 75%, Missing); liver: 45.4545% (minimum 75%, Missing); retina: 71.4286% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing)",-0.15,0.133333,-0.295455,0,80,unavailable,1.2,0.2,1,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164175,SLC45A2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 71.4286% (minimum 75%, Baseline (adaptation disabled)); liver: 45.4545% (minimum 75%, Baseline (adaptation disabled)); retina: 71.4286% (minimum 75%, Baseline (adaptation disabled)); skin: 50.0000% (minimum 65%, Baseline (adaptation disabled))",-0.15,0.133333,-0.295455,0,80,unavailable,1.2,0.2,1,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164175,SLC45A2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.5000% (minimum 95%, Missing); adrenal gland: 90.2439% (minimum 99%, Missing); basal ganglia: 88.0952% (minimum 99%, Missing); bone marrow: 94.8718% (minimum 99%, Missing); cerebral cortex: 97.3684% (minimum 99%, Missing); choroid plexus: 97.3684% (minimum 99%, Missing); colon: 52.1127% (minimum 97%, Missing); duodenum: 69.8113% (minimum 99%, Missing); esophagus: 82.2222% (minimum 97%, Missing); heart muscle: 68.5185% (minimum 99%, Missing); hypothalamus: 68.5185% (minimum 99%, Missing); kidney: 92.5000% (minimum 99%, Missing); liver: 66.0714% (minimum 99%, Missing); lung: 88.0952% (minimum 99%, Missing); midbrain: 58.7302% (minimum 99%, Missing); pancreas: 78.7234% (minimum 99%, Missing); parathyroid gland: 94.8718% (minimum 97%, Missing); pituitary gland: 92.5000% (minimum 99%, Missing); rectum: 69.8113% (minimum 97%, Missing); retina: 43.5294% (minimum 99%, Missing); salivary gland: 50.6849% (minimum 97%, Missing); skin: 62.7119% (minimum 95%, Missing); small intestine: 62.7119% (minimum 99%, Missing); smooth muscle: 50.6849% (minimum 99%, Missing); spinal cord: 97.3684% (minimum 99%, Missing); spleen: 92.5000% (minimum 95%, Missing); stomach: 74.0000% (minimum 97%, Missing); thymus: 84.0909% (minimum 95%, Missing); thyroid gland: 94.8718% (minimum 95%, Missing); tongue: 88.0952% (minimum 97%, Missing); urinary bladder: 80.4348% (minimum 97%, Missing)",-0.322881,-0.463151,-0.554706,0,80,unavailable,4.8,3.6,2.2,"retina: 4.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164220,F2RL2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 52.1127% (minimum 70%, Missing); duodenum: 69.8113% (minimum 75%, Missing); heart muscle: 68.5185% (minimum 75%, Missing); hypothalamus: 68.5185% (minimum 75%, Missing); liver: 66.0714% (minimum 75%, Missing); midbrain: 58.7302% (minimum 75%, Missing); rectum: 69.8113% (minimum 70%, Missing); retina: 43.5294% (minimum 75%, Missing); salivary gland: 50.6849% (minimum 70%, Missing); skin: 62.7119% (minimum 65%, Missing); small intestine: 62.7119% (minimum 75%, Missing); smooth muscle: 50.6849% (minimum 75%, Missing)",-0.0228814,-0.193151,-0.314706,0,80,unavailable,4.8,3.6,2.2,"retina: 4.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164220,F2RL2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 52.1127% (minimum 70%, Missing); duodenum: 69.8113% (minimum 75%, Missing); heart muscle: 68.5185% (minimum 75%, Missing); hypothalamus: 68.5185% (minimum 75%, Missing); liver: 66.0714% (minimum 75%, Missing); midbrain: 58.7302% (minimum 75%, Missing); rectum: 69.8113% (minimum 70%, Missing); retina: 43.5294% (minimum 75%, Missing); salivary gland: 50.6849% (minimum 70%, Missing); skin: 62.7119% (minimum 65%, Missing); small intestine: 62.7119% (minimum 75%, Missing); smooth muscle: 50.6849% (minimum 75%, Missing)",-0.0228814,-0.193151,-0.314706,0,80,unavailable,4.8,3.6,2.2,"retina: 4.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164220,F2RL2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 52.1127% (minimum 70%, Missing); duodenum: 69.8113% (minimum 75%, Missing); heart muscle: 68.5185% (minimum 75%, Missing); hypothalamus: 68.5185% (minimum 75%, Missing); liver: 66.0714% (minimum 75%, Missing); midbrain: 58.7302% (minimum 75%, Missing); rectum: 69.8113% (minimum 70%, Missing); retina: 43.5294% (minimum 75%, Missing); salivary gland: 50.6849% (minimum 70%, Missing); skin: 62.7119% (minimum 65%, Missing); small intestine: 62.7119% (minimum 75%, Missing); smooth muscle: 50.6849% (minimum 75%, Missing)",-0.0228814,-0.193151,-0.314706,0,80,unavailable,4.8,3.6,2.2,"retina: 4.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164220,F2RL2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 52.1127% (minimum 70%, Baseline (adaptation disabled)); duodenum: 69.8113% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 68.5185% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.5185% (minimum 75%, Baseline (adaptation disabled)); liver: 66.0714% (minimum 75%, Baseline (adaptation disabled)); midbrain: 58.7302% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.8113% (minimum 70%, Baseline (adaptation disabled)); retina: 43.5294% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.6849% (minimum 70%, Baseline (adaptation disabled)); skin: 62.7119% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.7119% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 50.6849% (minimum 75%, Baseline (adaptation disabled))",-0.0228814,-0.193151,-0.314706,0,80,unavailable,4.8,3.6,2.2,"retina: 4.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164220,F2RL2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 81.0811% (minimum 95%, Missing); adrenal gland: 80.5369% (minimum 99%, Missing); amygdala: 84.5070% (minimum 99%, Missing); basal ganglia: 82.7586% (minimum 99%, Missing); bone marrow: 77.4194% (minimum 99%, Missing); cerebellum: 85.7143% (minimum 99%, Missing); cerebral cortex: 85.7143% (minimum 99%, Missing); choroid plexus: 71.8563% (minimum 99%, Missing); colon: 64.1711% (minimum 97%, Missing); duodenum: 68.5714% (minimum 99%, Missing); esophagus: 68.9655% (minimum 97%, Missing); heart muscle: 64.8649% (minimum 99%, Missing); hippocampal formation: 86.3309% (minimum 99%, Missing); hypothalamus: 79.4702% (minimum 99%, Missing); kidney: 67.0391% (minimum 99%, Missing); liver: 70.1754% (minimum 99%, Missing); lung: 76.4331% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 79.4702% (minimum 99%, Missing); pancreas: 70.1754% (minimum 99%, Missing); parathyroid gland: 67.4157% (minimum 97%, Missing); pituitary gland: 64.1711% (minimum 99%, Missing); rectum: 51.0638% (minimum 97%, Missing); retina: 48.5830% (minimum 99%, Missing); salivary gland: 73.1707% (minimum 97%, Missing); skeletal muscle: 71.0059% (minimum 99%, Missing); skin: 75.9494% (minimum 95%, Missing); small intestine: 66.2983% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spinal cord: 86.9565% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 61.8557% (minimum 97%, Missing); thymus: 69.7674% (minimum 95%, Missing); thyroid gland: 58.2524% (minimum 95%, Missing); tongue: 72.2892% (minimum 97%, Missing); urinary bladder: 75.4717% (minimum 97%, Missing)",-0.367476,-0.459362,-0.50417,0,80,unavailable,12.7,11.5,8.6,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 2); thyroid gland: 8.6 nTPM (manageable, limit 5); lymph node: 8 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); pituitary gland: 6.7 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 2); salivary gland: 4.4 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164241,C5orf63,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 71.8563% (minimum 75%, Missing); colon: 64.1711% (minimum 70%, Missing); duodenum: 68.5714% (minimum 75%, Missing); esophagus: 68.9655% (minimum 70%, Missing); heart muscle: 64.8649% (minimum 75%, Missing); kidney: 67.0391% (minimum 75%, Missing); liver: 70.1754% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 70.1754% (minimum 75%, Missing); parathyroid gland: 67.4157% (minimum 70%, Missing); pituitary gland: 64.1711% (minimum 75%, Missing); rectum: 51.0638% (minimum 70%, Missing); retina: 48.5830% (minimum 75%, Missing); skeletal muscle: 71.0059% (minimum 75%, Missing); small intestine: 66.2983% (minimum 75%, Missing); stomach: 61.8557% (minimum 70%, Missing); thyroid gland: 58.2524% (minimum 65%, Missing)",-0.0674757,-0.189362,-0.26417,0,80,unavailable,12.7,11.5,8.6,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 2); thyroid gland: 8.6 nTPM (manageable, limit 5); lymph node: 8 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); pituitary gland: 6.7 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 2); salivary gland: 4.4 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164241,C5orf63,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 71.8563% (minimum 75%, Missing); colon: 64.1711% (minimum 70%, Missing); duodenum: 68.5714% (minimum 75%, Missing); esophagus: 68.9655% (minimum 70%, Missing); heart muscle: 64.8649% (minimum 75%, Missing); kidney: 67.0391% (minimum 75%, Missing); liver: 70.1754% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 70.1754% (minimum 75%, Missing); parathyroid gland: 67.4157% (minimum 70%, Missing); pituitary gland: 64.1711% (minimum 75%, Missing); rectum: 51.0638% (minimum 70%, Missing); retina: 48.5830% (minimum 75%, Missing); skeletal muscle: 71.0059% (minimum 75%, Missing); small intestine: 66.2983% (minimum 75%, Missing); stomach: 61.8557% (minimum 70%, Missing); thyroid gland: 58.2524% (minimum 65%, Missing)",-0.0674757,-0.189362,-0.26417,0,80,unavailable,12.7,11.5,8.6,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 3); thyroid gland: 8.6 nTPM (manageable, limit 5); lymph node: 8 nTPM (protected, limit 3); stomach: 7.4 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); pituitary gland: 6.7 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 3); salivary gland: 4.4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164241,C5orf63,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 71.8563% (minimum 75%, Missing); colon: 64.1711% (minimum 70%, Missing); duodenum: 68.5714% (minimum 75%, Missing); esophagus: 68.9655% (minimum 70%, Missing); heart muscle: 64.8649% (minimum 75%, Missing); kidney: 67.0391% (minimum 75%, Missing); liver: 70.1754% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 70.1754% (minimum 75%, Missing); parathyroid gland: 67.4157% (minimum 70%, Missing); pituitary gland: 64.1711% (minimum 75%, Missing); rectum: 51.0638% (minimum 70%, Missing); retina: 48.5830% (minimum 75%, Missing); skeletal muscle: 71.0059% (minimum 75%, Missing); small intestine: 66.2983% (minimum 75%, Missing); stomach: 61.8557% (minimum 70%, Missing); thyroid gland: 58.2524% (minimum 65%, Missing)",-0.0674757,-0.189362,-0.26417,0,80,unavailable,12.7,11.5,8.6,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 3); thyroid gland: 8.6 nTPM (manageable, limit 5); lymph node: 8 nTPM (protected, limit 3); stomach: 7.4 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); pituitary gland: 6.7 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 3); salivary gland: 4.4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164241,C5orf63,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 71.8563% (minimum 75%, Baseline (adaptation disabled)); colon: 64.1711% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.5714% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.9655% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.8649% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.0391% (minimum 75%, Baseline (adaptation disabled)); liver: 70.1754% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 70.1754% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 67.4157% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 64.1711% (minimum 75%, Baseline (adaptation disabled)); rectum: 51.0638% (minimum 70%, Baseline (adaptation disabled)); retina: 48.5830% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 71.0059% (minimum 75%, Baseline (adaptation disabled)); small intestine: 66.2983% (minimum 75%, Baseline (adaptation disabled)); stomach: 61.8557% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 58.2524% (minimum 65%, Baseline (adaptation disabled))",-0.0674757,-0.189362,-0.26417,0,80,unavailable,12.7,11.5,8.6,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 3); thyroid gland: 8.6 nTPM (manageable, limit 5); lymph node: 8 nTPM (protected, limit 3); stomach: 7.4 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); pituitary gland: 6.7 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 3); salivary gland: 4.4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164241,C5orf63,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.5000% (minimum 99%, Missing)",0.00121951,0.03,-0.015,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164256,PRDM9,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.30122,0.3,0.225,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164256,PRDM9,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.30122,0.3,0.225,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164256,PRDM9,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.30122,0.3,0.225,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164256,PRDM9,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.30122,0.3,0.225,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164256,PRDM9,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 89.2857% (minimum 99%, Missing); kidney: 69.4444% (minimum 99%, Missing); lung: 86.2069% (minimum 99%, Missing)",0.05,0.03,-0.295556,0,80,unavailable,1.1,0,0,"kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164287,CDC20B,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 69.4444% (minimum 75%, Missing)",0.35,0.3,-0.0555556,0,80,unavailable,1.1,0,0,"kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164287,CDC20B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 69.4444% (minimum 75%, Missing)",0.35,0.3,-0.0555556,0,80,unavailable,1.1,0,0,"kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164287,CDC20B,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 69.4444% (minimum 75%, Missing)",0.35,0.3,-0.0555556,0,80,unavailable,1.1,0,0,"kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164287,CDC20B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 69.4444% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.0555556,0,80,unavailable,1.1,0,0,"kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164287,CDC20B,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164299,SPZ1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164299,SPZ1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164299,SPZ1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164299,SPZ1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164299,SPZ1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.0784% (minimum 99%, Missing)",0.05,0.03,-0.0292157,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164304,CAGE1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.210784,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164304,CAGE1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.210784,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164304,CAGE1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.210784,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164304,CAGE1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.210784,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164304,CAGE1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.5816% (minimum 99%, Missing)",0.05,0.03,-0.0041844,0,4,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164334,FAM170A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235816,0,4,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164334,FAM170A,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235816,0,4,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164334,FAM170A,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235816,0,4,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164334,FAM170A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342857,0.3,0.235816,0,4,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164334,FAM170A,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 25.0000% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing)",0.05,0.03,-0.74,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000164399,IL3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.5,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000164399,IL3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.5,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000164399,IL3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.5,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000164399,IL3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 25.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.5,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000164399,IL3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.5484% (minimum 97%, Supported); amygdala: 88.7755% (minimum 99%, Missing); basal ganglia: 84.4660% (minimum 99%, Missing); bone marrow: 96.6667% (minimum 97%, Supported); cerebellum: 94.5652% (minimum 97%, Supported); cerebral cortex: 88.7755% (minimum 97%, Supported); choroid plexus: 95.6044% (minimum 99%, Missing); duodenum: 95.6044% (minimum 97%, Supported); heart muscle: 96.6667% (minimum 97%, Supported); hippocampal formation: 89.6907% (minimum 99%, Missing); hypothalamus: 87.8788% (minimum 99%, Missing); kidney: 86.1386% (minimum 97%, Supported); liver: 93.5484% (minimum 97%, Supported); midbrain: 88.7755% (minimum 99%, Missing); pancreas: 89.6907% (minimum 97%, Supported); pituitary gland: 84.4660% (minimum 99%, Missing); retina: 87.0000% (minimum 99%, Missing); skeletal muscle: 92.5532% (minimum 97%, Supported); small intestine: 95.6044% (minimum 97%, Supported); spinal cord: 90.6250% (minimum 99%, Missing); stomach: 89.6907% (minimum 90%, Supported); thymus: 92.5532% (minimum 95%, Missing); tongue: 93.5484% (minimum 97%, Missing)",-0.0244681,-0.0345161,-0.14534,0,1,partial,1.6,1,1,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164404,GDF9,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.275532,0.235484,0.0946602,0,1,partial,1.6,1,1,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164404,GDF9,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.275532,0.235484,0.0946602,0,1,partial,1.6,1,1,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164404,GDF9,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.275532,0.235484,0.0946602,0,1,partial,1.6,1,1,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164404,GDF9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.246907,0.196907,0.0946602,0,1,partial,1.6,1,1,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164404,GDF9,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.2008% (minimum 95%, Missing); adrenal gland: 60.4770% (minimum 99%, Missing); amygdala: 67.1078% (minimum 99%, Missing); basal ganglia: 65.2574% (minimum 99%, Missing); bone marrow: 76.1803% (minimum 99%, Missing); cerebellum: 53.5445% (minimum 99%, Missing); cerebral cortex: 62.3902% (minimum 99%, Missing); choroid plexus: 50.4979% (minimum 99%, Missing); colon: 48.1030% (minimum 97%, Missing); duodenum: 66.1080% (minimum 99%, Missing); esophagus: 72.4490% (minimum 97%, Missing); heart muscle: 69.6078% (minimum 99%, Missing); hippocampal formation: 63.9640% (minimum 99%, Missing); hypothalamus: 66.2313% (minimum 99%, Missing); kidney: 63.5063% (minimum 99%, Missing); liver: 52.7489% (minimum 99%, Missing); lung: 49.3741% (minimum 99%, Missing); lymph node: 66.9811% (minimum 97%, Missing); midbrain: 70.8583% (minimum 99%, Missing); pancreas: 69.8819% (minimum 99%, Missing); parathyroid gland: 60.7877% (minimum 97%, Missing); pituitary gland: 65.8627% (minimum 99%, Missing); rectum: 43.5049% (minimum 97%, Missing); retina: 71.7172% (minimum 99%, Missing); salivary gland: 53.6254% (minimum 97%, Missing); skeletal muscle: 72.7459% (minimum 99%, Missing); skin: 59.4640% (minimum 95%, Missing); small intestine: 62.9433% (minimum 99%, Missing); smooth muscle: 62.5000% (minimum 99%, Missing); spinal cord: 69.7446% (minimum 99%, Missing); spleen: 65.7407% (minimum 95%, Missing); stomach: 55.4688% (minimum 97%, Missing); thymus: 69.2008% (minimum 95%, Missing); thyroid gland: 68.4008% (minimum 95%, Missing); tongue: 70.2970% (minimum 97%, Missing); urinary bladder: 63.0551% (minimum 97%, Missing)",-0.35536,-0.534951,-0.496259,0,80,unavailable,36.4,46.1,24.2,"rectum: 46.1 nTPM (protected, limit 2); colon: 38.3 nTPM (protected, limit 2); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); salivary gland: 30.7 nTPM (protected, limit 2); stomach: 28.5 nTPM (protected, limit 2); skin: 24.2 nTPM (manageable, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 2); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 2); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); basal ganglia: 18.9 nTPM (vital, limit 1); spleen: 18.5 nTPM (manageable, limit 5); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 2); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (manageable, limit 5); thymus: 15.8 nTPM (manageable, limit 5); adipose tissue: 15.8 nTPM (manageable, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); tongue: 15 nTPM (protected, limit 2); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 2); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164414,SLC35A1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 60.4770% (minimum 75%, Missing); amygdala: 67.1078% (minimum 75%, Missing); basal ganglia: 65.2574% (minimum 75%, Missing); cerebellum: 53.5445% (minimum 75%, Missing); cerebral cortex: 62.3902% (minimum 75%, Missing); choroid plexus: 50.4979% (minimum 75%, Missing); colon: 48.1030% (minimum 70%, Missing); duodenum: 66.1080% (minimum 75%, Missing); heart muscle: 69.6078% (minimum 75%, Missing); hippocampal formation: 63.9640% (minimum 75%, Missing); hypothalamus: 66.2313% (minimum 75%, Missing); kidney: 63.5063% (minimum 75%, Missing); liver: 52.7489% (minimum 75%, Missing); lung: 49.3741% (minimum 75%, Missing); lymph node: 66.9811% (minimum 70%, Missing); midbrain: 70.8583% (minimum 75%, Missing); pancreas: 69.8819% (minimum 75%, Missing); parathyroid gland: 60.7877% (minimum 70%, Missing); pituitary gland: 65.8627% (minimum 75%, Missing); rectum: 43.5049% (minimum 70%, Missing); retina: 71.7172% (minimum 75%, Missing); salivary gland: 53.6254% (minimum 70%, Missing); skeletal muscle: 72.7459% (minimum 75%, Missing); skin: 59.4640% (minimum 65%, Missing); small intestine: 62.9433% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spinal cord: 69.7446% (minimum 75%, Missing); stomach: 55.4688% (minimum 70%, Missing); urinary bladder: 63.0551% (minimum 70%, Missing)",-0.0553601,-0.264951,-0.256259,0,80,unavailable,36.4,46.1,24.2,"rectum: 46.1 nTPM (protected, limit 2); colon: 38.3 nTPM (protected, limit 2); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); salivary gland: 30.7 nTPM (protected, limit 2); stomach: 28.5 nTPM (protected, limit 2); skin: 24.2 nTPM (manageable, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 2); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 2); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); basal ganglia: 18.9 nTPM (vital, limit 1); spleen: 18.5 nTPM (manageable, limit 5); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 2); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (manageable, limit 5); thymus: 15.8 nTPM (manageable, limit 5); adipose tissue: 15.8 nTPM (manageable, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); tongue: 15 nTPM (protected, limit 2); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 2); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164414,SLC35A1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 60.4770% (minimum 75%, Missing); amygdala: 67.1078% (minimum 75%, Missing); basal ganglia: 65.2574% (minimum 75%, Missing); cerebellum: 53.5445% (minimum 75%, Missing); cerebral cortex: 62.3902% (minimum 75%, Missing); choroid plexus: 50.4979% (minimum 75%, Missing); colon: 48.1030% (minimum 70%, Missing); duodenum: 66.1080% (minimum 75%, Missing); heart muscle: 69.6078% (minimum 75%, Missing); hippocampal formation: 63.9640% (minimum 75%, Missing); hypothalamus: 66.2313% (minimum 75%, Missing); kidney: 63.5063% (minimum 75%, Missing); liver: 52.7489% (minimum 75%, Missing); lung: 49.3741% (minimum 75%, Missing); lymph node: 66.9811% (minimum 70%, Missing); midbrain: 70.8583% (minimum 75%, Missing); pancreas: 69.8819% (minimum 75%, Missing); parathyroid gland: 60.7877% (minimum 70%, Missing); pituitary gland: 65.8627% (minimum 75%, Missing); rectum: 43.5049% (minimum 70%, Missing); retina: 71.7172% (minimum 75%, Missing); salivary gland: 53.6254% (minimum 70%, Missing); skeletal muscle: 72.7459% (minimum 75%, Missing); skin: 59.4640% (minimum 65%, Missing); small intestine: 62.9433% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spinal cord: 69.7446% (minimum 75%, Missing); stomach: 55.4688% (minimum 70%, Missing); urinary bladder: 63.0551% (minimum 70%, Missing)",-0.0553601,-0.264951,-0.256259,0,80,unavailable,36.4,46.1,24.2,"rectum: 46.1 nTPM (protected, limit 3); colon: 38.3 nTPM (protected, limit 3); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); salivary gland: 30.7 nTPM (protected, limit 3); stomach: 28.5 nTPM (protected, limit 3); skin: 24.2 nTPM (manageable, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 3); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 3); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); basal ganglia: 18.9 nTPM (vital, limit 1); spleen: 18.5 nTPM (manageable, limit 5); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 3); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (manageable, limit 5); thymus: 15.8 nTPM (manageable, limit 5); adipose tissue: 15.8 nTPM (manageable, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); tongue: 15 nTPM (protected, limit 3); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 3); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164414,SLC35A1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 60.4770% (minimum 75%, Missing); amygdala: 67.1078% (minimum 75%, Missing); basal ganglia: 65.2574% (minimum 75%, Missing); cerebellum: 53.5445% (minimum 75%, Missing); cerebral cortex: 62.3902% (minimum 75%, Missing); choroid plexus: 50.4979% (minimum 75%, Missing); colon: 48.1030% (minimum 70%, Missing); duodenum: 66.1080% (minimum 75%, Missing); heart muscle: 69.6078% (minimum 75%, Missing); hippocampal formation: 63.9640% (minimum 75%, Missing); hypothalamus: 66.2313% (minimum 75%, Missing); kidney: 63.5063% (minimum 75%, Missing); liver: 52.7489% (minimum 75%, Missing); lung: 49.3741% (minimum 75%, Missing); lymph node: 66.9811% (minimum 70%, Missing); midbrain: 70.8583% (minimum 75%, Missing); pancreas: 69.8819% (minimum 75%, Missing); parathyroid gland: 60.7877% (minimum 70%, Missing); pituitary gland: 65.8627% (minimum 75%, Missing); rectum: 43.5049% (minimum 70%, Missing); retina: 71.7172% (minimum 75%, Missing); salivary gland: 53.6254% (minimum 70%, Missing); skeletal muscle: 72.7459% (minimum 75%, Missing); skin: 59.4640% (minimum 65%, Missing); small intestine: 62.9433% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spinal cord: 69.7446% (minimum 75%, Missing); stomach: 55.4688% (minimum 70%, Missing); urinary bladder: 63.0551% (minimum 70%, Missing)",-0.0553601,-0.264951,-0.256259,0,80,unavailable,36.4,46.1,24.2,"rectum: 46.1 nTPM (protected, limit 3); colon: 38.3 nTPM (protected, limit 3); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); salivary gland: 30.7 nTPM (protected, limit 3); stomach: 28.5 nTPM (protected, limit 3); skin: 24.2 nTPM (manageable, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 3); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 3); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); basal ganglia: 18.9 nTPM (vital, limit 1); spleen: 18.5 nTPM (manageable, limit 5); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 3); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (manageable, limit 5); thymus: 15.8 nTPM (manageable, limit 5); adipose tissue: 15.8 nTPM (manageable, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); tongue: 15 nTPM (protected, limit 3); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 3); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164414,SLC35A1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 60.4770% (minimum 75%, Baseline (adaptation disabled)); amygdala: 67.1078% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.2574% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 53.5445% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.3902% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 50.4979% (minimum 75%, Baseline (adaptation disabled)); colon: 48.1030% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.1080% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 69.6078% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.9640% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.2313% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.5063% (minimum 75%, Baseline (adaptation disabled)); liver: 52.7489% (minimum 75%, Baseline (adaptation disabled)); lung: 49.3741% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.9811% (minimum 70%, Baseline (adaptation disabled)); midbrain: 70.8583% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.8819% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.7877% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 65.8627% (minimum 75%, Baseline (adaptation disabled)); rectum: 43.5049% (minimum 70%, Baseline (adaptation disabled)); retina: 71.7172% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.6254% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 72.7459% (minimum 75%, Baseline (adaptation disabled)); skin: 59.4640% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.9433% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.7446% (minimum 75%, Baseline (adaptation disabled)); stomach: 55.4688% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.0551% (minimum 70%, Baseline (adaptation disabled))",-0.0553601,-0.264951,-0.256259,0,80,unavailable,36.4,46.1,24.2,"rectum: 46.1 nTPM (protected, limit 3); colon: 38.3 nTPM (protected, limit 3); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); salivary gland: 30.7 nTPM (protected, limit 3); stomach: 28.5 nTPM (protected, limit 3); skin: 24.2 nTPM (manageable, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 3); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 3); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); basal ganglia: 18.9 nTPM (vital, limit 1); spleen: 18.5 nTPM (manageable, limit 5); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 3); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (manageable, limit 5); thymus: 15.8 nTPM (manageable, limit 5); adipose tissue: 15.8 nTPM (manageable, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); tongue: 15 nTPM (protected, limit 3); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 3); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164414,SLC35A1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 87.5486% (minimum 99%, Missing); heart muscle: 98.6842% (minimum 99%, Missing); skeletal muscle: 98.6842% (minimum 99%, Missing); skin: 85.2273% (minimum 95%, Missing)",-0.0977273,0.0168421,-0.114514,0,80,unavailable,3.2,0.3,3.9,"choroid plexus: 3.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164451,CALHM4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.202273,0.286842,0.125486,0,80,unavailable,3.2,0.3,3.9,"choroid plexus: 3.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164451,CALHM4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.202273,0.286842,0.125486,0,80,unavailable,3.2,0.3,3.9,"choroid plexus: 3.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164451,CALHM4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.202273,0.286842,0.125486,0,80,unavailable,3.2,0.3,3.9,"choroid plexus: 3.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164451,CALHM4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.202273,0.286842,0.125486,0,80,unavailable,3.2,0.3,3.9,"choroid plexus: 3.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164451,CALHM4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Missing); adrenal gland: 65.6250% (minimum 99%, Missing); amygdala: 79.2453% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); bone marrow: 50.0000% (minimum 99%, Missing); cerebellum: 95.4545% (minimum 99%, Missing); cerebral cortex: 89.3617% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 77.7778% (minimum 97%, Missing); duodenum: 85.7143% (minimum 99%, Missing); esophagus: 85.7143% (minimum 97%, Missing); heart muscle: 89.3617% (minimum 99%, Missing); hippocampal formation: 63.6364% (minimum 99%, Missing); hypothalamus: 72.4138% (minimum 99%, Missing); kidney: 79.2453% (minimum 99%, Missing); liver: 71.1864% (minimum 99%, Missing); lung: 56.7568% (minimum 99%, Missing); lymph node: 29.3706% (minimum 97%, Missing); midbrain: 89.3617% (minimum 99%, Missing); pancreas: 79.2453% (minimum 99%, Missing); pituitary gland: 47.1910% (minimum 99%, Missing); rectum: 65.6250% (minimum 97%, Missing); retina: 76.3636% (minimum 99%, Missing); salivary gland: 85.7143% (minimum 97%, Missing); skeletal muscle: 84.0000% (minimum 99%, Missing); skin: 89.3617% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 71.1864% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 31.8182% (minimum 95%, Missing); stomach: 72.4138% (minimum 97%, Missing); thymus: 40.7767% (minimum 95%, Missing); thyroid gland: 84.0000% (minimum 95%, Missing); tongue: 85.7143% (minimum 97%, Missing); urinary bladder: 76.3636% (minimum 97%, Missing)",-0.631818,-0.676294,-0.51809,0,80,unavailable,4.7,10.1,9,"lymph node: 10.1 nTPM (protected, limit 2); spleen: 9 nTPM (manageable, limit 5); thymus: 6.1 nTPM (manageable, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164483,SAMD3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.6250% (minimum 75%, Missing); bone marrow: 50.0000% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 72.4138% (minimum 75%, Missing); liver: 71.1864% (minimum 75%, Missing); lung: 56.7568% (minimum 75%, Missing); lymph node: 29.3706% (minimum 70%, Missing); pituitary gland: 47.1910% (minimum 75%, Missing); rectum: 65.6250% (minimum 70%, Missing); smooth muscle: 71.1864% (minimum 75%, Missing); spleen: 31.8182% (minimum 65%, Missing); thymus: 40.7767% (minimum 65%, Missing)",-0.331818,-0.406294,-0.27809,0,80,unavailable,4.7,10.1,9,"lymph node: 10.1 nTPM (protected, limit 2); spleen: 9 nTPM (manageable, limit 5); thymus: 6.1 nTPM (manageable, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164483,SAMD3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.6250% (minimum 75%, Missing); bone marrow: 50.0000% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 72.4138% (minimum 75%, Missing); liver: 71.1864% (minimum 75%, Missing); lung: 56.7568% (minimum 75%, Missing); lymph node: 29.3706% (minimum 70%, Missing); pituitary gland: 47.1910% (minimum 75%, Missing); rectum: 65.6250% (minimum 70%, Missing); smooth muscle: 71.1864% (minimum 75%, Missing); spleen: 31.8182% (minimum 65%, Missing); thymus: 40.7767% (minimum 65%, Missing)",-0.331818,-0.406294,-0.27809,0,80,unavailable,4.7,10.1,9,"lymph node: 10.1 nTPM (protected, limit 3); spleen: 9 nTPM (manageable, limit 5); thymus: 6.1 nTPM (manageable, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164483,SAMD3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.6250% (minimum 75%, Missing); bone marrow: 50.0000% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 72.4138% (minimum 75%, Missing); liver: 71.1864% (minimum 75%, Missing); lung: 56.7568% (minimum 75%, Missing); lymph node: 29.3706% (minimum 70%, Missing); pituitary gland: 47.1910% (minimum 75%, Missing); rectum: 65.6250% (minimum 70%, Missing); smooth muscle: 71.1864% (minimum 75%, Missing); spleen: 31.8182% (minimum 65%, Missing); thymus: 40.7767% (minimum 65%, Missing)",-0.331818,-0.406294,-0.27809,0,80,unavailable,4.7,10.1,9,"lymph node: 10.1 nTPM (protected, limit 3); spleen: 9 nTPM (manageable, limit 5); thymus: 6.1 nTPM (manageable, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164483,SAMD3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.6250% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.6364% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.4138% (minimum 75%, Baseline (adaptation disabled)); liver: 71.1864% (minimum 75%, Baseline (adaptation disabled)); lung: 56.7568% (minimum 75%, Baseline (adaptation disabled)); lymph node: 29.3706% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 47.1910% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.6250% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 71.1864% (minimum 75%, Baseline (adaptation disabled)); spleen: 31.8182% (minimum 65%, Baseline (adaptation disabled)); thymus: 40.7767% (minimum 65%, Baseline (adaptation disabled))",-0.331818,-0.406294,-0.27809,0,80,unavailable,4.7,10.1,9,"lymph node: 10.1 nTPM (protected, limit 3); spleen: 9 nTPM (manageable, limit 5); thymus: 6.1 nTPM (manageable, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164483,SAMD3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.6744% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); duodenum: 97.6744% (minimum 99%, Missing); pituitary gland: 97.6744% (minimum 99%, Missing)",0.05,0.00674419,-0.0566667,0,80,unavailable,0.3,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164500,SPMIP7,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.276744,0.183333,0,80,unavailable,0.3,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164500,SPMIP7,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.276744,0.183333,0,80,unavailable,0.3,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164500,SPMIP7,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.276744,0.183333,0,80,unavailable,0.3,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164500,SPMIP7,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.276744,0.183333,0,80,unavailable,0.3,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164500,SPMIP7,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.0633% (minimum 99%, Missing); amygdala: 73.7288% (minimum 99%, Missing); basal ganglia: 73.7288% (minimum 99%, Missing); bone marrow: 66.4122% (minimum 99%, Missing); cerebellum: 48.8764% (minimum 99%, Missing); cerebral cortex: 47.5410% (minimum 99%, Missing); choroid plexus: 97.7528% (minimum 99%, Missing); colon: 57.2368% (minimum 97%, Missing); duodenum: 70.1613% (minimum 99%, Missing); esophagus: 50.5814% (minimum 97%, Missing); heart muscle: 71.9008% (minimum 95%, Enhanced); hippocampal formation: 70.7317% (minimum 99%, Missing); hypothalamus: 67.4419% (minimum 99%, Missing); kidney: 83.6538% (minimum 99%, Missing); liver: 84.4660% (minimum 99%, Missing); lung: 71.3115% (minimum 99%, Missing); lymph node: 70.1613% (minimum 80%, Enhanced); midbrain: 74.3590% (minimum 99%, Missing); pancreas: 50.5814% (minimum 99%, Missing); parathyroid gland: 19.1209% (minimum 97%, Missing); pituitary gland: 57.2368% (minimum 99%, Missing); rectum: 63.5036% (minimum 97%, Missing); retina: 63.0435% (minimum 99%, Missing); salivary gland: 64.4444% (minimum 97%, Missing); skeletal muscle: 55.0633% (minimum 95%, Enhanced); skin: 47.5410% (minimum 95%, Missing); small intestine: 53.0488% (minimum 99%, Missing); smooth muscle: 76.9912% (minimum 95%, Enhanced); spinal cord: 75.6522% (minimum 99%, Missing); stomach: 71.9008% (minimum 97%, Missing); thymus: 79.0909% (minimum 95%, Missing); thyroid gland: 69.6000% (minimum 95%, Missing); tongue: 68.5039% (minimum 97%, Missing); urinary bladder: 67.4419% (minimum 97%, Missing)",-0.47459,-0.778791,-0.51459,0,9,partial,9.6,36.8,9.6,"parathyroid gland: 36.8 nTPM (protected, limit 2); cerebral cortex: 9.6 nTPM (vital, limit 1); skin: 9.6 nTPM (manageable, limit 5); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 6); colon: 6.5 nTPM (protected, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); retina: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); salivary gland: 4.8 nTPM (protected, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); hypothalamus: 4.2 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2); duodenum: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164506,STXBP5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.0633% (minimum 75%, Missing); amygdala: 73.7288% (minimum 75%, Missing); basal ganglia: 73.7288% (minimum 75%, Missing); bone marrow: 66.4122% (minimum 75%, Missing); cerebellum: 48.8764% (minimum 75%, Missing); cerebral cortex: 47.5410% (minimum 75%, Missing); colon: 57.2368% (minimum 70%, Missing); duodenum: 70.1613% (minimum 75%, Missing); esophagus: 50.5814% (minimum 70%, Missing); hippocampal formation: 70.7317% (minimum 75%, Missing); hypothalamus: 67.4419% (minimum 75%, Missing); lung: 71.3115% (minimum 75%, Missing); midbrain: 74.3590% (minimum 75%, Missing); pancreas: 50.5814% (minimum 75%, Missing); parathyroid gland: 19.1209% (minimum 70%, Missing); pituitary gland: 57.2368% (minimum 75%, Missing); rectum: 63.5036% (minimum 70%, Missing); retina: 63.0435% (minimum 75%, Missing); salivary gland: 64.4444% (minimum 70%, Missing); skeletal muscle: 55.0633% (minimum 60%, Enhanced); skin: 47.5410% (minimum 65%, Missing); small intestine: 53.0488% (minimum 75%, Missing); tongue: 68.5039% (minimum 70%, Missing); urinary bladder: 67.4419% (minimum 70%, Missing)",-0.17459,-0.508791,-0.27459,0,9,partial,9.6,36.8,9.6,"parathyroid gland: 36.8 nTPM (protected, limit 2); cerebral cortex: 9.6 nTPM (vital, limit 1); skin: 9.6 nTPM (manageable, limit 5); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 6); colon: 6.5 nTPM (protected, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); retina: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); salivary gland: 4.8 nTPM (protected, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); hypothalamus: 4.2 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2); duodenum: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164506,STXBP5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.0633% (minimum 75%, Missing); amygdala: 73.7288% (minimum 75%, Missing); basal ganglia: 73.7288% (minimum 75%, Missing); bone marrow: 66.4122% (minimum 75%, Missing); cerebellum: 48.8764% (minimum 75%, Missing); cerebral cortex: 47.5410% (minimum 75%, Missing); colon: 57.2368% (minimum 70%, Missing); duodenum: 70.1613% (minimum 75%, Missing); esophagus: 50.5814% (minimum 70%, Missing); hippocampal formation: 70.7317% (minimum 75%, Missing); hypothalamus: 67.4419% (minimum 75%, Missing); lung: 71.3115% (minimum 75%, Missing); midbrain: 74.3590% (minimum 75%, Missing); pancreas: 50.5814% (minimum 75%, Missing); parathyroid gland: 19.1209% (minimum 70%, Missing); pituitary gland: 57.2368% (minimum 75%, Missing); rectum: 63.5036% (minimum 70%, Missing); retina: 63.0435% (minimum 75%, Missing); salivary gland: 64.4444% (minimum 70%, Missing); skeletal muscle: 55.0633% (minimum 60%, Enhanced); skin: 47.5410% (minimum 65%, Missing); small intestine: 53.0488% (minimum 75%, Missing); tongue: 68.5039% (minimum 70%, Missing); urinary bladder: 67.4419% (minimum 70%, Missing)",-0.17459,-0.508791,-0.27459,0,9,partial,9.6,36.8,9.6,"parathyroid gland: 36.8 nTPM (protected, limit 3); cerebral cortex: 9.6 nTPM (vital, limit 1); skin: 9.6 nTPM (manageable, limit 5); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 6); colon: 6.5 nTPM (protected, limit 3); pituitary gland: 6.5 nTPM (vital, limit 1); retina: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); salivary gland: 4.8 nTPM (protected, limit 3); bone marrow: 4.4 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); hypothalamus: 4.2 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3); duodenum: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164506,STXBP5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.0633% (minimum 75%, Missing); amygdala: 73.7288% (minimum 75%, Missing); basal ganglia: 73.7288% (minimum 75%, Missing); bone marrow: 66.4122% (minimum 75%, Missing); cerebellum: 48.8764% (minimum 75%, Missing); cerebral cortex: 47.5410% (minimum 75%, Missing); colon: 57.2368% (minimum 70%, Missing); duodenum: 70.1613% (minimum 75%, Missing); esophagus: 50.5814% (minimum 70%, Missing); hippocampal formation: 70.7317% (minimum 75%, Missing); hypothalamus: 67.4419% (minimum 75%, Missing); lung: 71.3115% (minimum 75%, Missing); midbrain: 74.3590% (minimum 75%, Missing); pancreas: 50.5814% (minimum 75%, Missing); parathyroid gland: 19.1209% (minimum 70%, Missing); pituitary gland: 57.2368% (minimum 75%, Missing); rectum: 63.5036% (minimum 70%, Missing); retina: 63.0435% (minimum 75%, Missing); salivary gland: 64.4444% (minimum 70%, Missing); skeletal muscle: 55.0633% (minimum 60%, Enhanced); skin: 47.5410% (minimum 65%, Missing); small intestine: 53.0488% (minimum 75%, Missing); tongue: 68.5039% (minimum 70%, Missing); urinary bladder: 67.4419% (minimum 70%, Missing)",-0.17459,-0.508791,-0.27459,0,9,partial,9.6,36.8,9.6,"parathyroid gland: 36.8 nTPM (protected, limit 3); cerebral cortex: 9.6 nTPM (vital, limit 1); skin: 9.6 nTPM (manageable, limit 5); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 6); colon: 6.5 nTPM (protected, limit 3); pituitary gland: 6.5 nTPM (vital, limit 1); retina: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); salivary gland: 4.8 nTPM (protected, limit 3); bone marrow: 4.4 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); hypothalamus: 4.2 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3); duodenum: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164506,STXBP5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.0633% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.7288% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.7288% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.4122% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.8764% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 47.5410% (minimum 75%, Baseline (adaptation disabled)); colon: 57.2368% (minimum 70%, Baseline (adaptation disabled)); duodenum: 70.1613% (minimum 75%, Baseline (adaptation disabled)); esophagus: 50.5814% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 71.9008% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.7317% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.4419% (minimum 75%, Baseline (adaptation disabled)); lung: 71.3115% (minimum 75%, Baseline (adaptation disabled)); midbrain: 74.3590% (minimum 75%, Baseline (adaptation disabled)); pancreas: 50.5814% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 19.1209% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 57.2368% (minimum 75%, Baseline (adaptation disabled)); rectum: 63.5036% (minimum 70%, Baseline (adaptation disabled)); retina: 63.0435% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.4444% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.0633% (minimum 75%, Baseline (adaptation disabled)); skin: 47.5410% (minimum 65%, Baseline (adaptation disabled)); small intestine: 53.0488% (minimum 75%, Baseline (adaptation disabled)); tongue: 68.5039% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.4419% (minimum 70%, Baseline (adaptation disabled))",-0.17459,-0.508791,-0.27459,0,9,partial,9.6,36.8,9.6,"parathyroid gland: 36.8 nTPM (protected, limit 3); cerebral cortex: 9.6 nTPM (vital, limit 1); skin: 9.6 nTPM (manageable, limit 5); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 3); pituitary gland: 6.5 nTPM (vital, limit 1); retina: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); salivary gland: 4.8 nTPM (protected, limit 3); bone marrow: 4.4 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); hypothalamus: 4.2 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3); duodenum: 3.7 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164506,STXBP5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"kidney: 96.4912% (minimum 99%, Missing); liver: 98.2143% (minimum 99%, Missing); pancreas: 94.8276% (minimum 99%, Missing)",0.05,0.03,-0.0417241,0,2,partial,0.3,0,0,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164508,H2AC1,admission_only,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.35,0.3,0.198276,0,2,partial,0.3,0,0,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164508,H2AC1,selectivity_revised,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.35,0.3,0.198276,0,2,partial,0.3,0,0,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164508,H2AC1,grid_revised,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.35,0.3,0.198276,0,2,partial,0.3,0,0,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164508,H2AC1,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.35,0.3,0.198276,0,2,partial,0.3,0,0,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164508,H2AC1,current_fixed,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.9691% (minimum 99%, Uncertain); amygdala: 88.0734% (minimum 99%, Missing); basal ganglia: 78.6885% (minimum 99%, Missing); bone marrow: 93.2039% (minimum 99%, Missing); cerebellum: 97.9592% (minimum 99%, Missing); cerebral cortex: 88.0734% (minimum 99%, Missing); choroid plexus: 98.9691% (minimum 99%, Missing); duodenum: 98.9691% (minimum 99%, Missing); heart muscle: 98.9691% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); hypothalamus: 71.6418% (minimum 99%, Missing); kidney: 96.0000% (minimum 99%, Missing); liver: 76.1905% (minimum 99%, Missing); lung: 96.9697% (minimum 99%, Missing); lymph node: 73.2824% (minimum 97%, Missing); midbrain: 90.5660% (minimum 99%, Missing); pituitary gland: 97.9592% (minimum 99%, Missing); retina: 96.0000% (minimum 99%, Missing); salivary gland: 90.5660% (minimum 97%, Missing); small intestine: 88.0734% (minimum 99%, Missing); smooth muscle: 98.9691% (minimum 99%, Uncertain); spinal cord: 91.4286% (minimum 99%, Missing); spleen: 85.7143% (minimum 95%, Missing); thymus: 75.5906% (minimum 95%, Missing); urinary bladder: 96.9697% (minimum 97%, Missing)",-0.194094,-0.237176,-0.273582,0,2,partial,3.8,3.5,3.1,"hypothalamus: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164512,ANKRD55,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 71.6418% (minimum 75%, Missing)",0.105906,0.0328244,-0.0335821,0,2,partial,3.8,3.5,3.1,"hypothalamus: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164512,ANKRD55,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 71.6418% (minimum 75%, Missing)",0.105906,0.0328244,-0.0335821,0,2,partial,3.8,3.5,3.1,"hypothalamus: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164512,ANKRD55,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 71.6418% (minimum 75%, Missing)",0.105906,0.0328244,-0.0335821,0,2,partial,3.8,3.5,3.1,"hypothalamus: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164512,ANKRD55,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 71.6418% (minimum 75%, Baseline (adaptation disabled))",0.105906,0.0328244,-0.0335821,0,2,partial,3.8,3.5,3.1,"hypothalamus: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164512,ANKRD55,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.4694% (minimum 99%, Missing); amygdala: 85.7143% (minimum 99%, Missing); basal ganglia: 82.4427% (minimum 99%, Missing); bone marrow: 90.0000% (minimum 99%, Missing); cerebellum: 55.3846% (minimum 99%, Missing); cerebral cortex: 81.2030% (minimum 99%, Missing); choroid plexus: 77.1429% (minimum 99%, Missing); colon: 90.0000% (minimum 97%, Missing); duodenum: 92.7039% (minimum 99%, Missing); esophagus: 90.3766% (minimum 97%, Missing); heart muscle: 92.7039% (minimum 99%, Missing); hippocampal formation: 85.3755% (minimum 99%, Missing); hypothalamus: 79.1209% (minimum 99%, Missing); kidney: 71.0526% (minimum 99%, Missing); liver: 80.2974% (minimum 99%, Missing); lung: 88.1633% (minimum 99%, Missing); midbrain: 88.8889% (minimum 99%, Missing); pancreas: 71.0526% (minimum 99%, Missing); parathyroid gland: 65.6535% (minimum 97%, Missing); pituitary gland: 77.6978% (minimum 99%, Missing); rectum: 94.7368% (minimum 97%, Missing); retina: 59.8338% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); skeletal muscle: 93.5065% (minimum 99%, Missing); skin: 79.4118% (minimum 95%, Missing); small intestine: 95.1542% (minimum 99%, Missing); smooth muscle: 88.5246% (minimum 99%, Missing); spinal cord: 86.0558% (minimum 99%, Missing); stomach: 66.6667% (minimum 97%, Missing); thymus: 87.4494% (minimum 95%, Missing); thyroid gland: 86.0558% (minimum 95%, Missing); tongue: 93.9130% (minimum 97%, Missing); urinary bladder: 94.7368% (minimum 97%, Missing)",-0.155882,-0.313465,-0.436154,0,80,unavailable,17.4,11.3,5.6,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 2); stomach: 10.8 nTPM (protected, limit 2); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); bone marrow: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164542,MATCAP2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.4694% (minimum 75%, Missing); cerebellum: 55.3846% (minimum 75%, Missing); kidney: 71.0526% (minimum 75%, Missing); pancreas: 71.0526% (minimum 75%, Missing); parathyroid gland: 65.6535% (minimum 70%, Missing); retina: 59.8338% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing)",0.144118,-0.043465,-0.196154,0,80,unavailable,17.4,11.3,5.6,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 2); stomach: 10.8 nTPM (protected, limit 2); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); bone marrow: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164542,MATCAP2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.4694% (minimum 75%, Missing); cerebellum: 55.3846% (minimum 75%, Missing); kidney: 71.0526% (minimum 75%, Missing); pancreas: 71.0526% (minimum 75%, Missing); parathyroid gland: 65.6535% (minimum 70%, Missing); retina: 59.8338% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing)",0.144118,-0.043465,-0.196154,0,80,unavailable,17.4,11.3,5.6,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 3); stomach: 10.8 nTPM (protected, limit 3); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164542,MATCAP2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.4694% (minimum 75%, Missing); cerebellum: 55.3846% (minimum 75%, Missing); kidney: 71.0526% (minimum 75%, Missing); pancreas: 71.0526% (minimum 75%, Missing); parathyroid gland: 65.6535% (minimum 70%, Missing); retina: 59.8338% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing)",0.144118,-0.043465,-0.196154,0,80,unavailable,17.4,11.3,5.6,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 3); stomach: 10.8 nTPM (protected, limit 3); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164542,MATCAP2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.4694% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.3846% (minimum 75%, Baseline (adaptation disabled)); kidney: 71.0526% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.0526% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.6535% (minimum 70%, Baseline (adaptation disabled)); retina: 59.8338% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 70%, Baseline (adaptation disabled))",0.144118,-0.043465,-0.196154,0,80,unavailable,17.4,11.3,5.6,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 3); stomach: 10.8 nTPM (protected, limit 3); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164542,MATCAP2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164556,CFAP144P1,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164556,CFAP144P1,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164556,CFAP144P1,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164556,CFAP144P1,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164556,CFAP144P1,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.4814% (minimum 99%, Missing); basal ganglia: 95.7818% (minimum 99%, Missing); bone marrow: 51.8891% (minimum 99%, Missing); choroid plexus: 94.2968% (minimum 99%, Missing); colon: 83.8916% (minimum 97%, Missing); duodenum: 87.6931% (minimum 99%, Missing); esophagus: 74.5948% (minimum 97%, Missing); hippocampal formation: 93.9845% (minimum 99%, Missing); hypothalamus: 96.3235% (minimum 99%, Missing); liver: 97.0924% (minimum 99%, Missing); lymph node: 68.1745% (minimum 97%, Missing); midbrain: 98.1556% (minimum 99%, Missing); pituitary gland: 97.5931% (minimum 99%, Missing); rectum: 79.9906% (minimum 97%, Missing); retina: 98.6674% (minimum 99%, Missing); skin: 82.9518% (minimum 95%, Missing); small intestine: 87.9195% (minimum 99%, Missing); smooth muscle: 90.2013% (minimum 95%, Enhanced); spinal cord: 98.6674% (minimum 99%, Missing); spleen: 90.3448% (minimum 95%, Missing); thymus: 57.9449% (minimum 95%, Missing)",-0.370551,-0.288255,-0.471109,0,5,partial,157.9,79.5,123.6,"bone marrow: 157.9 nTPM (vital, limit 1); thymus: 123.6 nTPM (manageable, limit 5); lymph node: 79.5 nTPM (protected, limit 2); thyroid gland: 76.9 nTPM (manageable, limit 30); esophagus: 58 nTPM (protected, limit 2); rectum: 42.6 nTPM (protected, limit 2); skin: 35 nTPM (manageable, limit 5); colon: 32.7 nTPM (protected, limit 2); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 6); spleen: 18.2 nTPM (manageable, limit 5); urinary bladder: 12.1 nTPM (protected, limit 12); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); lung: 8.4 nTPM (vital, limit 6); cerebral cortex: 7.8 nTPM (vital, limit 6); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164611,PTTG1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 51.8891% (minimum 75%, Missing); lymph node: 68.1745% (minimum 70%, Missing); thymus: 57.9449% (minimum 65%, Missing)",-0.0705512,-0.0182546,-0.231109,0,5,partial,157.9,79.5,123.6,"bone marrow: 157.9 nTPM (vital, limit 1); thymus: 123.6 nTPM (manageable, limit 5); lymph node: 79.5 nTPM (protected, limit 2); thyroid gland: 76.9 nTPM (manageable, limit 30); esophagus: 58 nTPM (protected, limit 2); rectum: 42.6 nTPM (protected, limit 2); skin: 35 nTPM (manageable, limit 5); colon: 32.7 nTPM (protected, limit 2); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 6); spleen: 18.2 nTPM (manageable, limit 5); urinary bladder: 12.1 nTPM (protected, limit 12); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); lung: 8.4 nTPM (vital, limit 6); cerebral cortex: 7.8 nTPM (vital, limit 6); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164611,PTTG1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 51.8891% (minimum 75%, Missing); lymph node: 68.1745% (minimum 70%, Missing); thymus: 57.9449% (minimum 65%, Missing)",-0.0705512,-0.0182546,-0.231109,0,5,partial,157.9,79.5,123.6,"bone marrow: 157.9 nTPM (vital, limit 1); thymus: 123.6 nTPM (manageable, limit 5); lymph node: 79.5 nTPM (protected, limit 3); thyroid gland: 76.9 nTPM (manageable, limit 30); esophagus: 58 nTPM (protected, limit 3); rectum: 42.6 nTPM (protected, limit 3); skin: 35 nTPM (manageable, limit 5); colon: 32.7 nTPM (protected, limit 3); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 6); spleen: 18.2 nTPM (manageable, limit 5); urinary bladder: 12.1 nTPM (protected, limit 12); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); lung: 8.4 nTPM (vital, limit 6); cerebral cortex: 7.8 nTPM (vital, limit 6); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164611,PTTG1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 51.8891% (minimum 75%, Missing); lymph node: 68.1745% (minimum 70%, Missing); thymus: 57.9449% (minimum 65%, Missing)",-0.0705512,-0.0182546,-0.231109,0,5,partial,157.9,79.5,123.6,"bone marrow: 157.9 nTPM (vital, limit 1); thymus: 123.6 nTPM (manageable, limit 5); lymph node: 79.5 nTPM (protected, limit 3); thyroid gland: 76.9 nTPM (manageable, limit 30); esophagus: 58 nTPM (protected, limit 3); rectum: 42.6 nTPM (protected, limit 3); skin: 35 nTPM (manageable, limit 5); colon: 32.7 nTPM (protected, limit 3); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 6); spleen: 18.2 nTPM (manageable, limit 5); urinary bladder: 12.1 nTPM (protected, limit 12); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); lung: 8.4 nTPM (vital, limit 6); cerebral cortex: 7.8 nTPM (vital, limit 6); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164611,PTTG1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 51.8891% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.1745% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.9449% (minimum 65%, Baseline (adaptation disabled))",-0.0705512,-0.0182546,-0.231109,0,5,partial,157.9,79.5,123.6,"bone marrow: 157.9 nTPM (vital, limit 1); thymus: 123.6 nTPM (manageable, limit 5); lymph node: 79.5 nTPM (protected, limit 3); thyroid gland: 76.9 nTPM (manageable, limit 5); esophagus: 58 nTPM (protected, limit 3); rectum: 42.6 nTPM (protected, limit 3); skin: 35 nTPM (manageable, limit 5); colon: 32.7 nTPM (protected, limit 3); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); urinary bladder: 12.1 nTPM (protected, limit 3); stomach: 11.5 nTPM (protected, limit 3); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 3); lung: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164611,PTTG1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.4444% (minimum 95%, Enhanced); amygdala: 60.0000% (minimum 99%, Missing); basal ganglia: 55.4348% (minimum 99%, Missing); cerebellum: 79.6875% (minimum 95%, Enhanced); cerebral cortex: 56.6667% (minimum 99%, Missing); choroid plexus: 70.8333% (minimum 99%, Missing); duodenum: 92.7273% (minimum 95%, Enhanced); heart muscle: 94.4444% (minimum 95%, Enhanced); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 50.4950% (minimum 99%, Missing); kidney: 94.4444% (minimum 95%, Enhanced); liver: 94.4444% (minimum 95%, Enhanced); lung: 87.9310% (minimum 95%, Enhanced); midbrain: 36.4286% (minimum 99%, Missing); pancreas: 92.7273% (minimum 95%, Enhanced); pituitary gland: 80.9524% (minimum 99%, Missing); retina: 63.7500% (minimum 99%, Missing); skeletal muscle: 92.7273% (minimum 95%, Enhanced); spinal cord: 40.8000% (minimum 99%, Missing); thyroid gland: 91.0714% (minimum 95%, Missing); tongue: 96.2264% (minimum 97%, Missing)",-0.0392857,-0.00773585,-0.625714,0,7,partial,8.9,0.3,0.5,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164627,KIF6,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 55.4348% (minimum 75%, Missing); cerebral cortex: 56.6667% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.4950% (minimum 75%, Missing); midbrain: 36.4286% (minimum 75%, Missing); retina: 63.7500% (minimum 75%, Missing); spinal cord: 40.8000% (minimum 75%, Missing)",0.260714,0.262264,-0.385714,0,7,partial,8.9,0.3,0.5,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164627,KIF6,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 55.4348% (minimum 75%, Missing); cerebral cortex: 56.6667% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.4950% (minimum 75%, Missing); midbrain: 36.4286% (minimum 75%, Missing); retina: 63.7500% (minimum 75%, Missing); spinal cord: 40.8000% (minimum 75%, Missing)",0.260714,0.262264,-0.385714,0,7,partial,8.9,0.3,0.5,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164627,KIF6,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 55.4348% (minimum 75%, Missing); cerebral cortex: 56.6667% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.4950% (minimum 75%, Missing); midbrain: 36.4286% (minimum 75%, Missing); retina: 63.7500% (minimum 75%, Missing); spinal cord: 40.8000% (minimum 75%, Missing)",0.260714,0.262264,-0.385714,0,7,partial,8.9,0.3,0.5,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164627,KIF6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.4348% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.6667% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.8333% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 50.4950% (minimum 75%, Baseline (adaptation disabled)); midbrain: 36.4286% (minimum 75%, Baseline (adaptation disabled)); retina: 63.7500% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 40.8000% (minimum 75%, Baseline (adaptation disabled))",0.260714,0.244444,-0.385714,0,7,partial,8.9,0.3,0.5,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164627,KIF6,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0464539,0.03,0.0064539,0,80,unavailable,0.1,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164645,TEX47,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346454,0.3,0.246454,0,80,unavailable,0.1,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164645,TEX47,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346454,0.3,0.246454,0,80,unavailable,0.1,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164645,TEX47,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346454,0.3,0.246454,0,80,unavailable,0.1,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164645,TEX47,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346454,0.3,0.246454,0,80,unavailable,0.1,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164645,TEX47,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6667% (minimum 95%, Uncertain); adrenal gland: 63.5135% (minimum 99%, Missing); amygdala: 59.4937% (minimum 99%, Missing); basal ganglia: 61.0390% (minimum 99%, Missing); bone marrow: 48.9583% (minimum 99%, Missing); cerebellum: 43.1193% (minimum 99%, Missing); cerebral cortex: 54.6512% (minimum 99%, Missing); choroid plexus: 83.9286% (minimum 99%, Missing); colon: 65.2778% (minimum 97%, Missing); duodenum: 74.6032% (minimum 99%, Missing); esophagus: 72.3077% (minimum 97%, Missing); heart muscle: 70.1493% (minimum 99%, Missing); hippocampal formation: 58.7500% (minimum 99%, Missing); hypothalamus: 57.3171% (minimum 99%, Missing); kidney: 71.2121% (minimum 99%, Missing); liver: 74.6032% (minimum 99%, Missing); lung: 63.5135% (minimum 99%, Missing); lymph node: 66.1972% (minimum 97%, Missing); midbrain: 65.2778% (minimum 99%, Missing); pancreas: 71.2121% (minimum 99%, Missing); parathyroid gland: 77.0492% (minimum 97%, Missing); pituitary gland: 63.5135% (minimum 99%, Missing); rectum: 77.0492% (minimum 97%, Missing); retina: 35.0746% (minimum 99%, Missing); salivary gland: 70.1493% (minimum 97%, Missing); skeletal muscle: 63.5135% (minimum 99%, Missing); skin: 61.8421% (minimum 95%, Missing); small intestine: 73.4375% (minimum 99%, Missing); smooth muscle: 77.0492% (minimum 99%, Uncertain); spinal cord: 65.2778% (minimum 99%, Missing); spleen: 66.1972% (minimum 95%, Missing); stomach: 72.3077% (minimum 97%, Missing); thymus: 42.7273% (minimum 95%, Missing); thyroid gland: 40.8696% (minimum 95%, Missing); tongue: 82.4561% (minimum 97%, Missing); urinary bladder: 66.1972% (minimum 97%, Missing)",-0.541304,-0.317222,-0.639254,0,3,partial,8.7,2.5,6.8,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164663,USP49,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6667% (minimum 65%, Uncertain); adrenal gland: 63.5135% (minimum 75%, Missing); amygdala: 59.4937% (minimum 75%, Missing); basal ganglia: 61.0390% (minimum 75%, Missing); bone marrow: 48.9583% (minimum 75%, Missing); cerebellum: 43.1193% (minimum 75%, Missing); cerebral cortex: 54.6512% (minimum 75%, Missing); colon: 65.2778% (minimum 70%, Missing); duodenum: 74.6032% (minimum 75%, Missing); heart muscle: 70.1493% (minimum 75%, Missing); hippocampal formation: 58.7500% (minimum 75%, Missing); hypothalamus: 57.3171% (minimum 75%, Missing); kidney: 71.2121% (minimum 75%, Missing); liver: 74.6032% (minimum 75%, Missing); lung: 63.5135% (minimum 75%, Missing); lymph node: 66.1972% (minimum 70%, Missing); midbrain: 65.2778% (minimum 75%, Missing); pancreas: 71.2121% (minimum 75%, Missing); pituitary gland: 63.5135% (minimum 75%, Missing); retina: 35.0746% (minimum 75%, Missing); skeletal muscle: 63.5135% (minimum 75%, Missing); skin: 61.8421% (minimum 65%, Missing); small intestine: 73.4375% (minimum 75%, Missing); spinal cord: 65.2778% (minimum 75%, Missing); thymus: 42.7273% (minimum 65%, Missing); thyroid gland: 40.8696% (minimum 65%, Missing); urinary bladder: 66.1972% (minimum 70%, Missing)",-0.241304,-0.0472222,-0.399254,0,3,partial,8.7,2.5,6.8,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164663,USP49,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6667% (minimum 65%, Uncertain); adrenal gland: 63.5135% (minimum 75%, Missing); amygdala: 59.4937% (minimum 75%, Missing); basal ganglia: 61.0390% (minimum 75%, Missing); bone marrow: 48.9583% (minimum 75%, Missing); cerebellum: 43.1193% (minimum 75%, Missing); cerebral cortex: 54.6512% (minimum 75%, Missing); colon: 65.2778% (minimum 70%, Missing); duodenum: 74.6032% (minimum 75%, Missing); heart muscle: 70.1493% (minimum 75%, Missing); hippocampal formation: 58.7500% (minimum 75%, Missing); hypothalamus: 57.3171% (minimum 75%, Missing); kidney: 71.2121% (minimum 75%, Missing); liver: 74.6032% (minimum 75%, Missing); lung: 63.5135% (minimum 75%, Missing); lymph node: 66.1972% (minimum 70%, Missing); midbrain: 65.2778% (minimum 75%, Missing); pancreas: 71.2121% (minimum 75%, Missing); pituitary gland: 63.5135% (minimum 75%, Missing); retina: 35.0746% (minimum 75%, Missing); skeletal muscle: 63.5135% (minimum 75%, Missing); skin: 61.8421% (minimum 65%, Missing); small intestine: 73.4375% (minimum 75%, Missing); spinal cord: 65.2778% (minimum 75%, Missing); thymus: 42.7273% (minimum 65%, Missing); thyroid gland: 40.8696% (minimum 65%, Missing); urinary bladder: 66.1972% (minimum 70%, Missing)",-0.241304,-0.0472222,-0.399254,0,3,partial,8.7,2.5,6.8,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164663,USP49,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6667% (minimum 65%, Uncertain); adrenal gland: 63.5135% (minimum 75%, Missing); amygdala: 59.4937% (minimum 75%, Missing); basal ganglia: 61.0390% (minimum 75%, Missing); bone marrow: 48.9583% (minimum 75%, Missing); cerebellum: 43.1193% (minimum 75%, Missing); cerebral cortex: 54.6512% (minimum 75%, Missing); colon: 65.2778% (minimum 70%, Missing); duodenum: 74.6032% (minimum 75%, Missing); heart muscle: 70.1493% (minimum 75%, Missing); hippocampal formation: 58.7500% (minimum 75%, Missing); hypothalamus: 57.3171% (minimum 75%, Missing); kidney: 71.2121% (minimum 75%, Missing); liver: 74.6032% (minimum 75%, Missing); lung: 63.5135% (minimum 75%, Missing); lymph node: 66.1972% (minimum 70%, Missing); midbrain: 65.2778% (minimum 75%, Missing); pancreas: 71.2121% (minimum 75%, Missing); pituitary gland: 63.5135% (minimum 75%, Missing); retina: 35.0746% (minimum 75%, Missing); skeletal muscle: 63.5135% (minimum 75%, Missing); skin: 61.8421% (minimum 65%, Missing); small intestine: 73.4375% (minimum 75%, Missing); spinal cord: 65.2778% (minimum 75%, Missing); thymus: 42.7273% (minimum 65%, Missing); thyroid gland: 40.8696% (minimum 65%, Missing); urinary bladder: 66.1972% (minimum 70%, Missing)",-0.241304,-0.0472222,-0.399254,0,3,partial,8.7,2.5,6.8,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164663,USP49,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6667% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.5135% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.4937% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.0390% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 48.9583% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.1193% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 54.6512% (minimum 75%, Baseline (adaptation disabled)); colon: 65.2778% (minimum 70%, Baseline (adaptation disabled)); duodenum: 74.6032% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.1493% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.7500% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 57.3171% (minimum 75%, Baseline (adaptation disabled)); kidney: 71.2121% (minimum 75%, Baseline (adaptation disabled)); liver: 74.6032% (minimum 75%, Baseline (adaptation disabled)); lung: 63.5135% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.1972% (minimum 70%, Baseline (adaptation disabled)); midbrain: 65.2778% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.2121% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 63.5135% (minimum 75%, Baseline (adaptation disabled)); retina: 35.0746% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 63.5135% (minimum 75%, Baseline (adaptation disabled)); skin: 61.8421% (minimum 65%, Baseline (adaptation disabled)); small intestine: 73.4375% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.2778% (minimum 75%, Baseline (adaptation disabled)); thymus: 42.7273% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 40.8696% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 66.1972% (minimum 70%, Baseline (adaptation disabled))",-0.241304,-0.0472222,-0.399254,0,3,partial,8.7,2.5,6.8,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164663,USP49,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.1873% (minimum 99%, Missing); basal ganglia: 98.7842% (minimum 99%, Missing); choroid plexus: 93.3908% (minimum 99%, Missing); hippocampal formation: 98.7842% (minimum 99%, Missing); hypothalamus: 98.4848% (minimum 99%, Missing); kidney: 91.8079% (minimum 99%, Missing); lung: 97.8916% (minimum 99%, Missing); parathyroid gland: 95.3079% (minimum 97%, Missing); pituitary gland: 97.0149% (minimum 99%, Missing); retina: 97.0149% (minimum 99%, Missing); thyroid gland: 91.8079% (minimum 95%, Missing)",-0.0319209,-0.0169208,-0.0719209,0,80,unavailable,2.9,1.6,2.9,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164675,IQUB,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.268079,0.253079,0.168079,0,80,unavailable,2.9,1.6,2.9,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164675,IQUB,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.268079,0.253079,0.168079,0,80,unavailable,2.9,1.6,2.9,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164675,IQUB,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.268079,0.253079,0.168079,0,80,unavailable,2.9,1.6,2.9,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164675,IQUB,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.268079,0.253079,0.168079,0,80,unavailable,2.9,1.6,2.9,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164675,IQUB,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skeletal muscle: 95.8333% (minimum 99%, Missing)",0.05,0.03,-0.0316667,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000164729,SLC35G3,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000164729,SLC35G3,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000164729,SLC35G3,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000164729,SLC35G3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000164729,SLC35G3,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.00753086,0,3,partial,0.1,0,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced),52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / keratinocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164744,SUN3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.247531,0,3,partial,0.1,0,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced),52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / keratinocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164744,SUN3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.247531,0,3,partial,0.1,0,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced),52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / keratinocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164744,SUN3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.247531,0,3,partial,0.1,0,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced),52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / keratinocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164744,SUN3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.347531,0.3,0.247531,0,3,partial,0.1,0,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced),52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / keratinocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164744,SUN3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.0556% (minimum 99%, Missing); basal ganglia: 88.7417% (minimum 99%, Missing); choroid plexus: 63.8095% (minimum 99%, Missing); hippocampal formation: 89.3333% (minimum 99%, Missing); hypothalamus: 87.0130% (minimum 99%, Missing); lung: 86.4516% (minimum 95%, Enhanced); midbrain: 98.5294% (minimum 99%, Missing); pituitary gland: 98.5294% (minimum 99%, Missing); retina: 96.4029% (minimum 99%, Missing); spinal cord: 97.1014% (minimum 99%, Missing)",0.05,0.03,-0.351905,0,3,partial,7.6,0.8,0.2,"choroid plexus: 7.6 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164746,C7orf57,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.8095% (minimum 75%, Missing)",0.35,0.3,-0.111905,0,3,partial,7.6,0.8,0.2,"choroid plexus: 7.6 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164746,C7orf57,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.8095% (minimum 75%, Missing)",0.35,0.3,-0.111905,0,3,partial,7.6,0.8,0.2,"choroid plexus: 7.6 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164746,C7orf57,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.8095% (minimum 75%, Missing)",0.35,0.3,-0.111905,0,3,partial,7.6,0.8,0.2,"choroid plexus: 7.6 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164746,C7orf57,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.8095% (minimum 75%, Baseline (adaptation disabled))",0.335294,0.243662,-0.111905,0,3,partial,7.6,0.8,0.2,"choroid plexus: 7.6 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164746,C7orf57,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 34.6154% (minimum 99%, Missing); basal ganglia: 31.0345% (minimum 99%, Missing); cerebellum: 64.2857% (minimum 99%, Missing); cerebral cortex: 25.0000% (minimum 99%, Missing); choroid plexus: 90.0000% (minimum 99%, Missing); hippocampal formation: 36.0000% (minimum 99%, Missing); hypothalamus: 30.0000% (minimum 99%, Missing); midbrain: 52.9412% (minimum 99%, Missing); pancreas: 81.8182% (minimum 99%, Missing); pituitary gland: 90.0000% (minimum 99%, Missing); retina: 60.0000% (minimum 99%, Missing); spinal cord: 64.2857% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing)",-0.2,0.03,-0.74,0,80,unavailable,2.7,0,0.3,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164796,CSMD3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 34.6154% (minimum 75%, Missing); basal ganglia: 31.0345% (minimum 75%, Missing); cerebellum: 64.2857% (minimum 75%, Missing); cerebral cortex: 25.0000% (minimum 75%, Missing); hippocampal formation: 36.0000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 52.9412% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing)",0.1,0.3,-0.5,0,80,unavailable,2.7,0,0.3,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164796,CSMD3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 34.6154% (minimum 75%, Missing); basal ganglia: 31.0345% (minimum 75%, Missing); cerebellum: 64.2857% (minimum 75%, Missing); cerebral cortex: 25.0000% (minimum 75%, Missing); hippocampal formation: 36.0000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 52.9412% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing)",0.1,0.3,-0.5,0,80,unavailable,2.7,0,0.3,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164796,CSMD3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 34.6154% (minimum 75%, Missing); basal ganglia: 31.0345% (minimum 75%, Missing); cerebellum: 64.2857% (minimum 75%, Missing); cerebral cortex: 25.0000% (minimum 75%, Missing); hippocampal formation: 36.0000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 52.9412% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing)",0.1,0.3,-0.5,0,80,unavailable,2.7,0,0.3,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164796,CSMD3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 34.6154% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 31.0345% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.2857% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 25.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 36.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 30.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 52.9412% (minimum 75%, Baseline (adaptation disabled)); retina: 60.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.2857% (minimum 75%, Baseline (adaptation disabled))",0.1,0.3,-0.5,0,80,unavailable,2.7,0,0.3,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164796,CSMD3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 66.4311% (minimum 99%, Missing); amygdala: 74.0157% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 76.7347% (minimum 99%, Missing); cerebellum: 59.6825% (minimum 99%, Missing); cerebral cortex: 63.5135% (minimum 99%, Missing); choroid plexus: 77.6860% (minimum 99%, Missing); colon: 61.8421% (minimum 97%, Missing); duodenum: 69.6296% (minimum 99%, Missing); esophagus: 64.6048% (minimum 97%, Missing); heart muscle: 75.5020% (minimum 99%, Missing); hippocampal formation: 69.8885% (minimum 99%, Missing); hypothalamus: 68.6131% (minimum 99%, Missing); kidney: 65.2778% (minimum 99%, Missing); liver: 52.6611% (minimum 99%, Missing); lung: 75.2000% (minimum 99%, Missing); lymph node: 61.2378% (minimum 97%, Missing); midbrain: 74.0157% (minimum 99%, Missing); pancreas: 57.3171% (minimum 99%, Missing); parathyroid gland: 65.7343% (minimum 95%, Approved); pituitary gland: 72.0307% (minimum 99%, Missing); rectum: 60.2564% (minimum 97%, Missing); retina: 57.8462% (minimum 99%, Missing); salivary gland: 68.6131% (minimum 97%, Missing); skeletal muscle: 68.3636% (minimum 99%, Missing); skin: 62.6667% (minimum 95%, Missing); small intestine: 72.0307% (minimum 99%, Missing); smooth muscle: 64.1638% (minimum 99%, Missing); spinal cord: 75.5020% (minimum 99%, Missing); spleen: 68.1159% (minimum 95%, Missing); stomach: 65.2778% (minimum 97%, Missing); thymus: 59.3060% (minimum 95%, Missing); thyroid gland: 65.5052% (minimum 95%, Missing); tongue: 71.2121% (minimum 97%, Missing); urinary bladder: 63.9456% (minimum 97%, Missing)",-0.35694,-0.367436,-0.463389,0,0,routine_complete,16.9,12.4,12.9,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); thymus: 12.9 nTPM (manageable, limit 5); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 2); lymph node: 11.9 nTPM (protected, limit 2); colon: 11.6 nTPM (protected, limit 2); skin: 11.2 nTPM (manageable, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 2); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 2); kidney: 10 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 2); thyroid gland: 9.9 nTPM (manageable, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 4); adrenal gland: 9.5 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (manageable, limit 5); basal ganglia: 9.4 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 2); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 2); small intestine: 7.3 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164815,ORC5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.4311% (minimum 75%, Missing); amygdala: 74.0157% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 59.6825% (minimum 75%, Missing); cerebral cortex: 63.5135% (minimum 75%, Missing); colon: 61.8421% (minimum 70%, Missing); duodenum: 69.6296% (minimum 75%, Missing); esophagus: 64.6048% (minimum 70%, Missing); hippocampal formation: 69.8885% (minimum 75%, Missing); hypothalamus: 68.6131% (minimum 75%, Missing); kidney: 65.2778% (minimum 75%, Missing); liver: 52.6611% (minimum 75%, Missing); lymph node: 61.2378% (minimum 70%, Missing); midbrain: 74.0157% (minimum 75%, Missing); pancreas: 57.3171% (minimum 75%, Missing); pituitary gland: 72.0307% (minimum 75%, Missing); rectum: 60.2564% (minimum 70%, Missing); retina: 57.8462% (minimum 75%, Missing); salivary gland: 68.6131% (minimum 70%, Missing); skeletal muscle: 68.3636% (minimum 75%, Missing); skin: 62.6667% (minimum 65%, Missing); small intestine: 72.0307% (minimum 75%, Missing); smooth muscle: 64.1638% (minimum 75%, Missing); stomach: 65.2778% (minimum 70%, Missing); thymus: 59.3060% (minimum 65%, Missing); urinary bladder: 63.9456% (minimum 70%, Missing)",-0.0569401,-0.0974359,-0.223389,0,0,routine_complete,16.9,12.4,12.9,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); thymus: 12.9 nTPM (manageable, limit 5); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 2); lymph node: 11.9 nTPM (protected, limit 2); colon: 11.6 nTPM (protected, limit 2); skin: 11.2 nTPM (manageable, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 2); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 2); kidney: 10 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 2); thyroid gland: 9.9 nTPM (manageable, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 4); adrenal gland: 9.5 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (manageable, limit 5); basal ganglia: 9.4 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 2); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 2); small intestine: 7.3 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164815,ORC5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.4311% (minimum 75%, Missing); amygdala: 74.0157% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 59.6825% (minimum 75%, Missing); cerebral cortex: 63.5135% (minimum 75%, Missing); colon: 61.8421% (minimum 70%, Missing); duodenum: 69.6296% (minimum 75%, Missing); esophagus: 64.6048% (minimum 70%, Missing); hippocampal formation: 69.8885% (minimum 75%, Missing); hypothalamus: 68.6131% (minimum 75%, Missing); kidney: 65.2778% (minimum 75%, Missing); liver: 52.6611% (minimum 75%, Missing); lymph node: 61.2378% (minimum 70%, Missing); midbrain: 74.0157% (minimum 75%, Missing); pancreas: 57.3171% (minimum 75%, Missing); pituitary gland: 72.0307% (minimum 75%, Missing); rectum: 60.2564% (minimum 70%, Missing); retina: 57.8462% (minimum 75%, Missing); salivary gland: 68.6131% (minimum 70%, Missing); skeletal muscle: 68.3636% (minimum 75%, Missing); skin: 62.6667% (minimum 65%, Missing); small intestine: 72.0307% (minimum 75%, Missing); smooth muscle: 64.1638% (minimum 75%, Missing); stomach: 65.2778% (minimum 70%, Missing); thymus: 59.3060% (minimum 65%, Missing); urinary bladder: 63.9456% (minimum 70%, Missing)",-0.0569401,-0.0974359,-0.223389,0,0,routine_complete,16.9,12.4,12.9,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); thymus: 12.9 nTPM (manageable, limit 5); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 3); lymph node: 11.9 nTPM (protected, limit 3); colon: 11.6 nTPM (protected, limit 3); skin: 11.2 nTPM (manageable, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 3); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 3); kidney: 10 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 3); thyroid gland: 9.9 nTPM (manageable, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 4); adrenal gland: 9.5 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (manageable, limit 5); basal ganglia: 9.4 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 3); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 3); small intestine: 7.3 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164815,ORC5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.4311% (minimum 75%, Missing); amygdala: 74.0157% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 59.6825% (minimum 75%, Missing); cerebral cortex: 63.5135% (minimum 75%, Missing); colon: 61.8421% (minimum 70%, Missing); duodenum: 69.6296% (minimum 75%, Missing); esophagus: 64.6048% (minimum 70%, Missing); hippocampal formation: 69.8885% (minimum 75%, Missing); hypothalamus: 68.6131% (minimum 75%, Missing); kidney: 65.2778% (minimum 75%, Missing); liver: 52.6611% (minimum 75%, Missing); lymph node: 61.2378% (minimum 70%, Missing); midbrain: 74.0157% (minimum 75%, Missing); pancreas: 57.3171% (minimum 75%, Missing); pituitary gland: 72.0307% (minimum 75%, Missing); rectum: 60.2564% (minimum 70%, Missing); retina: 57.8462% (minimum 75%, Missing); salivary gland: 68.6131% (minimum 70%, Missing); skeletal muscle: 68.3636% (minimum 75%, Missing); skin: 62.6667% (minimum 65%, Missing); small intestine: 72.0307% (minimum 75%, Missing); smooth muscle: 64.1638% (minimum 75%, Missing); stomach: 65.2778% (minimum 70%, Missing); thymus: 59.3060% (minimum 65%, Missing); urinary bladder: 63.9456% (minimum 70%, Missing)",-0.0569401,-0.0974359,-0.223389,0,0,routine_complete,16.9,12.4,12.9,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); thymus: 12.9 nTPM (manageable, limit 5); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 3); lymph node: 11.9 nTPM (protected, limit 3); colon: 11.6 nTPM (protected, limit 3); skin: 11.2 nTPM (manageable, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 3); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 3); kidney: 10 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 3); thyroid gland: 9.9 nTPM (manageable, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 4); adrenal gland: 9.5 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (manageable, limit 5); basal ganglia: 9.4 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 3); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 3); small intestine: 7.3 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164815,ORC5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.4311% (minimum 75%, Baseline (adaptation disabled)); amygdala: 74.0157% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 59.6825% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.5135% (minimum 75%, Baseline (adaptation disabled)); colon: 61.8421% (minimum 70%, Baseline (adaptation disabled)); duodenum: 69.6296% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.6048% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 69.8885% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.6131% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.2778% (minimum 75%, Baseline (adaptation disabled)); liver: 52.6611% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.2378% (minimum 70%, Baseline (adaptation disabled)); midbrain: 74.0157% (minimum 75%, Baseline (adaptation disabled)); pancreas: 57.3171% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.7343% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.0307% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.2564% (minimum 70%, Baseline (adaptation disabled)); retina: 57.8462% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.6131% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 68.3636% (minimum 75%, Baseline (adaptation disabled)); skin: 62.6667% (minimum 65%, Baseline (adaptation disabled)); small intestine: 72.0307% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.1638% (minimum 75%, Baseline (adaptation disabled)); stomach: 65.2778% (minimum 70%, Baseline (adaptation disabled)); thymus: 59.3060% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 63.9456% (minimum 70%, Baseline (adaptation disabled))",-0.0569401,-0.0974359,-0.223389,0,0,routine_complete,16.9,12.4,12.9,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); thymus: 12.9 nTPM (manageable, limit 5); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 3); lymph node: 11.9 nTPM (protected, limit 3); colon: 11.6 nTPM (protected, limit 3); skin: 11.2 nTPM (manageable, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 3); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 3); kidney: 10 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 3); thyroid gland: 9.9 nTPM (manageable, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 3); adrenal gland: 9.5 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (manageable, limit 5); basal ganglia: 9.4 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 3); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 3); small intestine: 7.3 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164815,ORC5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.00983721,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164871,SPAG11B,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249837,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164871,SPAG11B,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249837,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164871,SPAG11B,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249837,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164871,SPAG11B,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299919,0.249837,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164871,SPAG11B,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.9487% (minimum 90%, Approved); adrenal gland: 50.4464% (minimum 99%, Missing); amygdala: 46.6942% (minimum 99%, Missing); basal ganglia: 44.8413% (minimum 99%, Missing); bone marrow: 65.6977% (minimum 98%, Approved); cerebellum: 63.4831% (minimum 99%, Missing); cerebral cortex: 50.6726% (minimum 99%, Missing); choroid plexus: 32.0113% (minimum 99%, Missing); colon: 54.5894% (minimum 97%, Missing); duodenum: 62.7778% (minimum 99%, Missing); esophagus: 67.6647% (minimum 97%, Missing); heart muscle: 29.0488% (minimum 99%, Missing); hippocampal formation: 48.2906% (minimum 99%, Missing); hypothalamus: 47.4790% (minimum 99%, Missing); kidney: 41.6974% (minimum 99%, Missing); liver: 39.5105% (minimum 99%, Missing); lung: 69.3252% (minimum 99%, Missing); lymph node: 68.0723% (minimum 97%, Missing); midbrain: 46.3115% (minimum 99%, Missing); pancreas: 53.0516% (minimum 99%, Missing); parathyroid gland: 51.3636% (minimum 97%, Missing); pituitary gland: 49.1304% (minimum 99%, Missing); rectum: 69.7531% (minimum 97%, Missing); retina: 79.0210% (minimum 99%, Missing); salivary gland: 48.0851% (minimum 97%, Missing); skeletal muscle: 28.0397% (minimum 98%, Approved); skin: 70.1863% (minimum 95%, Missing); small intestine: 62.4309% (minimum 99%, Missing); smooth muscle: 75.8389% (minimum 98%, Approved); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 64.2045% (minimum 90%, Approved); stomach: 50.6726% (minimum 97%, Missing); thymus: 60.7527% (minimum 95%, Missing); thyroid gland: 52.0737% (minimum 95%, Missing); tongue: 23.3471% (minimum 97%, Missing); urinary bladder: 57.6531% (minimum 97%, Missing)",-0.429263,-0.736529,-0.699603,0,5,partial,29,37.1,10.4,"tongue: 37.1 nTPM (protected, limit 2); skeletal muscle: 29 nTPM (vital, limit 2); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); salivary gland: 12.2 nTPM (protected, limit 2); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 2); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 2); thyroid gland: 10.4 nTPM (manageable, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 2); urinary bladder: 8.3 nTPM (protected, limit 2); thymus: 7.3 nTPM (manageable, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 2); esophagus: 5.4 nTPM (protected, limit 2); lymph node: 5.3 nTPM (protected, limit 2); lung: 5 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164898,FMC1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.9487% (minimum 60%, Approved); adrenal gland: 50.4464% (minimum 75%, Missing); amygdala: 46.6942% (minimum 75%, Missing); basal ganglia: 44.8413% (minimum 75%, Missing); bone marrow: 65.6977% (minimum 70%, Approved); cerebellum: 63.4831% (minimum 75%, Missing); cerebral cortex: 50.6726% (minimum 75%, Missing); choroid plexus: 32.0113% (minimum 75%, Missing); colon: 54.5894% (minimum 70%, Missing); duodenum: 62.7778% (minimum 75%, Missing); esophagus: 67.6647% (minimum 70%, Missing); heart muscle: 29.0488% (minimum 75%, Missing); hippocampal formation: 48.2906% (minimum 75%, Missing); hypothalamus: 47.4790% (minimum 75%, Missing); kidney: 41.6974% (minimum 75%, Missing); liver: 39.5105% (minimum 75%, Missing); lung: 69.3252% (minimum 75%, Missing); lymph node: 68.0723% (minimum 70%, Missing); midbrain: 46.3115% (minimum 75%, Missing); pancreas: 53.0516% (minimum 75%, Missing); parathyroid gland: 51.3636% (minimum 70%, Missing); pituitary gland: 49.1304% (minimum 75%, Missing); rectum: 69.7531% (minimum 70%, Missing); salivary gland: 48.0851% (minimum 70%, Missing); skeletal muscle: 28.0397% (minimum 70%, Approved); small intestine: 62.4309% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); stomach: 50.6726% (minimum 70%, Missing); thymus: 60.7527% (minimum 65%, Missing); thyroid gland: 52.0737% (minimum 65%, Missing); tongue: 23.3471% (minimum 70%, Missing); urinary bladder: 57.6531% (minimum 70%, Missing)",-0.129263,-0.466529,-0.459512,0,5,partial,29,37.1,10.4,"tongue: 37.1 nTPM (protected, limit 2); skeletal muscle: 29 nTPM (vital, limit 2); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); salivary gland: 12.2 nTPM (protected, limit 2); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 2); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 2); thyroid gland: 10.4 nTPM (manageable, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 2); urinary bladder: 8.3 nTPM (protected, limit 2); thymus: 7.3 nTPM (manageable, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 2); esophagus: 5.4 nTPM (protected, limit 2); lymph node: 5.3 nTPM (protected, limit 2); lung: 5 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164898,FMC1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.9487% (minimum 60%, Approved); adrenal gland: 50.4464% (minimum 75%, Missing); amygdala: 46.6942% (minimum 75%, Missing); basal ganglia: 44.8413% (minimum 75%, Missing); bone marrow: 65.6977% (minimum 70%, Approved); cerebellum: 63.4831% (minimum 75%, Missing); cerebral cortex: 50.6726% (minimum 75%, Missing); choroid plexus: 32.0113% (minimum 75%, Missing); colon: 54.5894% (minimum 70%, Missing); duodenum: 62.7778% (minimum 75%, Missing); esophagus: 67.6647% (minimum 70%, Missing); heart muscle: 29.0488% (minimum 75%, Missing); hippocampal formation: 48.2906% (minimum 75%, Missing); hypothalamus: 47.4790% (minimum 75%, Missing); kidney: 41.6974% (minimum 75%, Missing); liver: 39.5105% (minimum 75%, Missing); lung: 69.3252% (minimum 75%, Missing); lymph node: 68.0723% (minimum 70%, Missing); midbrain: 46.3115% (minimum 75%, Missing); pancreas: 53.0516% (minimum 75%, Missing); parathyroid gland: 51.3636% (minimum 70%, Missing); pituitary gland: 49.1304% (minimum 75%, Missing); rectum: 69.7531% (minimum 70%, Missing); salivary gland: 48.0851% (minimum 70%, Missing); skeletal muscle: 28.0397% (minimum 70%, Approved); small intestine: 62.4309% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); stomach: 50.6726% (minimum 70%, Missing); thymus: 60.7527% (minimum 65%, Missing); thyroid gland: 52.0737% (minimum 65%, Missing); tongue: 23.3471% (minimum 70%, Missing); urinary bladder: 57.6531% (minimum 70%, Missing)",-0.129263,-0.466529,-0.459512,0,5,partial,29,37.1,10.4,"tongue: 37.1 nTPM (protected, limit 3); skeletal muscle: 29 nTPM (vital, limit 2); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); salivary gland: 12.2 nTPM (protected, limit 3); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 3); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 3); thyroid gland: 10.4 nTPM (manageable, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 3); urinary bladder: 8.3 nTPM (protected, limit 3); thymus: 7.3 nTPM (manageable, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 2); esophagus: 5.4 nTPM (protected, limit 3); lymph node: 5.3 nTPM (protected, limit 3); lung: 5 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164898,FMC1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.9487% (minimum 60%, Approved); adrenal gland: 50.4464% (minimum 75%, Missing); amygdala: 46.6942% (minimum 75%, Missing); basal ganglia: 44.8413% (minimum 75%, Missing); bone marrow: 65.6977% (minimum 70%, Approved); cerebellum: 63.4831% (minimum 75%, Missing); cerebral cortex: 50.6726% (minimum 75%, Missing); choroid plexus: 32.0113% (minimum 75%, Missing); colon: 54.5894% (minimum 70%, Missing); duodenum: 62.7778% (minimum 75%, Missing); esophagus: 67.6647% (minimum 70%, Missing); heart muscle: 29.0488% (minimum 75%, Missing); hippocampal formation: 48.2906% (minimum 75%, Missing); hypothalamus: 47.4790% (minimum 75%, Missing); kidney: 41.6974% (minimum 75%, Missing); liver: 39.5105% (minimum 75%, Missing); lung: 69.3252% (minimum 75%, Missing); lymph node: 68.0723% (minimum 70%, Missing); midbrain: 46.3115% (minimum 75%, Missing); pancreas: 53.0516% (minimum 75%, Missing); parathyroid gland: 51.3636% (minimum 70%, Missing); pituitary gland: 49.1304% (minimum 75%, Missing); rectum: 69.7531% (minimum 70%, Missing); salivary gland: 48.0851% (minimum 70%, Missing); skeletal muscle: 28.0397% (minimum 70%, Approved); small intestine: 62.4309% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); stomach: 50.6726% (minimum 70%, Missing); thymus: 60.7527% (minimum 65%, Missing); thyroid gland: 52.0737% (minimum 65%, Missing); tongue: 23.3471% (minimum 70%, Missing); urinary bladder: 57.6531% (minimum 70%, Missing)",-0.129263,-0.466529,-0.459512,0,5,partial,29,37.1,10.4,"tongue: 37.1 nTPM (protected, limit 3); skeletal muscle: 29 nTPM (vital, limit 2); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); salivary gland: 12.2 nTPM (protected, limit 3); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 3); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 3); thyroid gland: 10.4 nTPM (manageable, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 3); urinary bladder: 8.3 nTPM (protected, limit 3); thymus: 7.3 nTPM (manageable, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 2); esophagus: 5.4 nTPM (protected, limit 3); lymph node: 5.3 nTPM (protected, limit 3); lung: 5 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164898,FMC1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.9487% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 50.4464% (minimum 75%, Baseline (adaptation disabled)); amygdala: 46.6942% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 44.8413% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 65.6977% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 63.4831% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.6726% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 32.0113% (minimum 75%, Baseline (adaptation disabled)); colon: 54.5894% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.7778% (minimum 75%, Baseline (adaptation disabled)); esophagus: 67.6647% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 29.0488% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 48.2906% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 47.4790% (minimum 75%, Baseline (adaptation disabled)); kidney: 41.6974% (minimum 75%, Baseline (adaptation disabled)); liver: 39.5105% (minimum 75%, Baseline (adaptation disabled)); lung: 69.3252% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.0723% (minimum 70%, Baseline (adaptation disabled)); midbrain: 46.3115% (minimum 75%, Baseline (adaptation disabled)); pancreas: 53.0516% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.3636% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 49.1304% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.7531% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 48.0851% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 28.0397% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.4309% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.2045% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.6726% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.7527% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.0737% (minimum 65%, Baseline (adaptation disabled)); tongue: 23.3471% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.6531% (minimum 70%, Baseline (adaptation disabled))",-0.129263,-0.466529,-0.469603,0,5,partial,29,37.1,10.4,"tongue: 37.1 nTPM (protected, limit 3); skeletal muscle: 29 nTPM (vital, limit 1); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); salivary gland: 12.2 nTPM (protected, limit 3); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 3); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 3); thyroid gland: 10.4 nTPM (manageable, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 3); urinary bladder: 8.3 nTPM (protected, limit 3); adipose tissue: 8.2 nTPM (manageable, limit 5); thymus: 7.3 nTPM (manageable, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); spleen: 6.3 nTPM (manageable, limit 5); bone marrow: 5.9 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 3); lymph node: 5.3 nTPM (protected, limit 3); lung: 5 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164898,FMC1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.0392% (minimum 99%, Missing); heart muscle: 92.5926% (minimum 98%, Approved); skeletal muscle: 31.4465% (minimum 98%, Approved); spinal cord: 98.0392% (minimum 99%, Missing); tongue: 83.3333% (minimum 97%, Missing)",0.05,-0.136667,-0.665535,0,4,partial,10.9,1,0,"skeletal muscle: 10.9 nTPM (vital, limit 2)",,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164900,GBX1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 31.4465% (minimum 70%, Approved)",0.35,0.133333,-0.385535,0,4,partial,10.9,1,0,"skeletal muscle: 10.9 nTPM (vital, limit 2)",,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164900,GBX1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 31.4465% (minimum 70%, Approved)",0.35,0.133333,-0.385535,0,4,partial,10.9,1,0,"skeletal muscle: 10.9 nTPM (vital, limit 2)",,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164900,GBX1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 31.4465% (minimum 70%, Approved)",0.35,0.133333,-0.385535,0,4,partial,10.9,1,0,"skeletal muscle: 10.9 nTPM (vital, limit 2)",,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164900,GBX1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 31.4465% (minimum 75%, Baseline (adaptation disabled))",0.35,0.133333,-0.435535,0,4,partial,10.9,1,0,"skeletal muscle: 10.9 nTPM (vital, limit 1)",,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164900,GBX1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.4192% (minimum 95%, Missing); adrenal gland: 69.1057% (minimum 99%, Missing); amygdala: 75.5556% (minimum 99%, Missing); basal ganglia: 75.5556% (minimum 99%, Missing); bone marrow: 38.6364% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 69.1057% (minimum 99%, Missing); choroid plexus: 76.9231% (minimum 99%, Missing); colon: 63.9098% (minimum 97%, Missing); duodenum: 68.2731% (minimum 99%, Missing); esophagus: 64.3939% (minimum 97%, Missing); heart muscle: 63.9098% (minimum 98%, Approved); hippocampal formation: 76.2332% (minimum 99%, Missing); hypothalamus: 78.3410% (minimum 99%, Missing); kidney: 61.8182% (minimum 99%, Missing); liver: 58.4192% (minimum 98%, Approved); lung: 62.0438% (minimum 99%, Missing); lymph node: 54.6624% (minimum 97%, Missing); midbrain: 76.2332% (minimum 99%, Missing); pancreas: 62.9630% (minimum 99%, Missing); parathyroid gland: 54.3131% (minimum 97%, Missing); pituitary gland: 73.5931% (minimum 99%, Missing); rectum: 60.0707% (minimum 97%, Missing); retina: 58.6207% (minimum 99%, Missing); salivary gland: 64.6388% (minimum 95%, Approved); skeletal muscle: 66.9291% (minimum 99%, Missing); skin: 64.3939% (minimum 95%, Missing); small intestine: 65.8915% (minimum 99%, Missing); smooth muscle: 55.9211% (minimum 98%, Approved); spinal cord: 73.5931% (minimum 99%, Missing); spleen: 60.4982% (minimum 95%, Missing); stomach: 60.0707% (minimum 97%, Missing); thymus: 46.5753% (minimum 95%, Missing); thyroid gland: 56.8562% (minimum 95%, Missing); tongue: 65.6371% (minimum 97%, Missing); urinary bladder: 62.7306% (minimum 97%, Missing)",-0.484247,-0.426869,-0.603636,0,5,partial,27,14.3,19.5,"bone marrow: 27 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); parathyroid gland: 14.3 nTPM (protected, limit 2); lymph node: 14.1 nTPM (protected, limit 2); smooth muscle: 13.4 nTPM (vital, limit 2); thyroid gland: 12.9 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); liver: 12.1 nTPM (vital, limit 2); retina: 12 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 2); rectum: 11.3 nTPM (protected, limit 2); spleen: 11.1 nTPM (manageable, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 2); pancreas: 10 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 2); heart muscle: 9.6 nTPM (vital, limit 2); esophagus: 9.4 nTPM (protected, limit 2); skin: 9.4 nTPM (manageable, limit 5); salivary gland: 9.3 nTPM (protected, limit 4); tongue: 8.9 nTPM (protected, limit 2); small intestine: 8.8 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164944,VIRMA,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.4192% (minimum 65%, Missing); adrenal gland: 69.1057% (minimum 75%, Missing); bone marrow: 38.6364% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 69.1057% (minimum 75%, Missing); colon: 63.9098% (minimum 70%, Missing); duodenum: 68.2731% (minimum 75%, Missing); esophagus: 64.3939% (minimum 70%, Missing); heart muscle: 63.9098% (minimum 70%, Approved); kidney: 61.8182% (minimum 75%, Missing); liver: 58.4192% (minimum 70%, Approved); lung: 62.0438% (minimum 75%, Missing); lymph node: 54.6624% (minimum 70%, Missing); pancreas: 62.9630% (minimum 75%, Missing); parathyroid gland: 54.3131% (minimum 70%, Missing); pituitary gland: 73.5931% (minimum 75%, Missing); rectum: 60.0707% (minimum 70%, Missing); retina: 58.6207% (minimum 75%, Missing); salivary gland: 64.6388% (minimum 65%, Approved); skeletal muscle: 66.9291% (minimum 75%, Missing); skin: 64.3939% (minimum 65%, Missing); small intestine: 65.8915% (minimum 75%, Missing); smooth muscle: 55.9211% (minimum 70%, Approved); spinal cord: 73.5931% (minimum 75%, Missing); spleen: 60.4982% (minimum 65%, Missing); stomach: 60.0707% (minimum 70%, Missing); thymus: 46.5753% (minimum 65%, Missing); thyroid gland: 56.8562% (minimum 65%, Missing); tongue: 65.6371% (minimum 70%, Missing); urinary bladder: 62.7306% (minimum 70%, Missing)",-0.184247,-0.156869,-0.363636,0,5,partial,27,14.3,19.5,"bone marrow: 27 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); parathyroid gland: 14.3 nTPM (protected, limit 2); lymph node: 14.1 nTPM (protected, limit 2); smooth muscle: 13.4 nTPM (vital, limit 2); thyroid gland: 12.9 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); liver: 12.1 nTPM (vital, limit 2); retina: 12 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 2); rectum: 11.3 nTPM (protected, limit 2); spleen: 11.1 nTPM (manageable, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 2); pancreas: 10 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 2); heart muscle: 9.6 nTPM (vital, limit 2); esophagus: 9.4 nTPM (protected, limit 2); skin: 9.4 nTPM (manageable, limit 5); salivary gland: 9.3 nTPM (protected, limit 4); tongue: 8.9 nTPM (protected, limit 2); small intestine: 8.8 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164944,VIRMA,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.4192% (minimum 65%, Missing); adrenal gland: 69.1057% (minimum 75%, Missing); bone marrow: 38.6364% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 69.1057% (minimum 75%, Missing); colon: 63.9098% (minimum 70%, Missing); duodenum: 68.2731% (minimum 75%, Missing); esophagus: 64.3939% (minimum 70%, Missing); heart muscle: 63.9098% (minimum 70%, Approved); kidney: 61.8182% (minimum 75%, Missing); liver: 58.4192% (minimum 70%, Approved); lung: 62.0438% (minimum 75%, Missing); lymph node: 54.6624% (minimum 70%, Missing); pancreas: 62.9630% (minimum 75%, Missing); parathyroid gland: 54.3131% (minimum 70%, Missing); pituitary gland: 73.5931% (minimum 75%, Missing); rectum: 60.0707% (minimum 70%, Missing); retina: 58.6207% (minimum 75%, Missing); salivary gland: 64.6388% (minimum 65%, Approved); skeletal muscle: 66.9291% (minimum 75%, Missing); skin: 64.3939% (minimum 65%, Missing); small intestine: 65.8915% (minimum 75%, Missing); smooth muscle: 55.9211% (minimum 70%, Approved); spinal cord: 73.5931% (minimum 75%, Missing); spleen: 60.4982% (minimum 65%, Missing); stomach: 60.0707% (minimum 70%, Missing); thymus: 46.5753% (minimum 65%, Missing); thyroid gland: 56.8562% (minimum 65%, Missing); tongue: 65.6371% (minimum 70%, Missing); urinary bladder: 62.7306% (minimum 70%, Missing)",-0.184247,-0.156869,-0.363636,0,5,partial,27,14.3,19.5,"bone marrow: 27 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); parathyroid gland: 14.3 nTPM (protected, limit 3); lymph node: 14.1 nTPM (protected, limit 3); smooth muscle: 13.4 nTPM (vital, limit 2); thyroid gland: 12.9 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); liver: 12.1 nTPM (vital, limit 2); retina: 12 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 3); rectum: 11.3 nTPM (protected, limit 3); spleen: 11.1 nTPM (manageable, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 3); pancreas: 10 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 3); heart muscle: 9.6 nTPM (vital, limit 2); esophagus: 9.4 nTPM (protected, limit 3); skin: 9.4 nTPM (manageable, limit 5); salivary gland: 9.3 nTPM (protected, limit 4); tongue: 8.9 nTPM (protected, limit 3); small intestine: 8.8 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164944,VIRMA,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.4192% (minimum 65%, Missing); adrenal gland: 69.1057% (minimum 75%, Missing); bone marrow: 38.6364% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 69.1057% (minimum 75%, Missing); colon: 63.9098% (minimum 70%, Missing); duodenum: 68.2731% (minimum 75%, Missing); esophagus: 64.3939% (minimum 70%, Missing); heart muscle: 63.9098% (minimum 70%, Approved); kidney: 61.8182% (minimum 75%, Missing); liver: 58.4192% (minimum 70%, Approved); lung: 62.0438% (minimum 75%, Missing); lymph node: 54.6624% (minimum 70%, Missing); pancreas: 62.9630% (minimum 75%, Missing); parathyroid gland: 54.3131% (minimum 70%, Missing); pituitary gland: 73.5931% (minimum 75%, Missing); rectum: 60.0707% (minimum 70%, Missing); retina: 58.6207% (minimum 75%, Missing); salivary gland: 64.6388% (minimum 65%, Approved); skeletal muscle: 66.9291% (minimum 75%, Missing); skin: 64.3939% (minimum 65%, Missing); small intestine: 65.8915% (minimum 75%, Missing); smooth muscle: 55.9211% (minimum 70%, Approved); spinal cord: 73.5931% (minimum 75%, Missing); spleen: 60.4982% (minimum 65%, Missing); stomach: 60.0707% (minimum 70%, Missing); thymus: 46.5753% (minimum 65%, Missing); thyroid gland: 56.8562% (minimum 65%, Missing); tongue: 65.6371% (minimum 70%, Missing); urinary bladder: 62.7306% (minimum 70%, Missing)",-0.184247,-0.156869,-0.363636,0,5,partial,27,14.3,19.5,"bone marrow: 27 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); parathyroid gland: 14.3 nTPM (protected, limit 3); lymph node: 14.1 nTPM (protected, limit 3); smooth muscle: 13.4 nTPM (vital, limit 2); thyroid gland: 12.9 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); liver: 12.1 nTPM (vital, limit 2); retina: 12 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 3); rectum: 11.3 nTPM (protected, limit 3); spleen: 11.1 nTPM (manageable, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 3); pancreas: 10 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 3); heart muscle: 9.6 nTPM (vital, limit 2); esophagus: 9.4 nTPM (protected, limit 3); skin: 9.4 nTPM (manageable, limit 5); salivary gland: 9.3 nTPM (protected, limit 4); tongue: 8.9 nTPM (protected, limit 3); small intestine: 8.8 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164944,VIRMA,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.4192% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 69.1057% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 38.6364% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 69.1057% (minimum 75%, Baseline (adaptation disabled)); colon: 63.9098% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.2731% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.3939% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.9098% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.8182% (minimum 75%, Baseline (adaptation disabled)); liver: 58.4192% (minimum 75%, Baseline (adaptation disabled)); lung: 62.0438% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.6624% (minimum 70%, Baseline (adaptation disabled)); pancreas: 62.9630% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 54.3131% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 73.5931% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.0707% (minimum 70%, Baseline (adaptation disabled)); retina: 58.6207% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.6388% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 66.9291% (minimum 75%, Baseline (adaptation disabled)); skin: 64.3939% (minimum 65%, Baseline (adaptation disabled)); small intestine: 65.8915% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.9211% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.5931% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.4982% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.0707% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.5753% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.8562% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.6371% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.7306% (minimum 70%, Baseline (adaptation disabled))",-0.184247,-0.156869,-0.363636,0,5,partial,27,14.3,19.5,"bone marrow: 27 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); parathyroid gland: 14.3 nTPM (protected, limit 3); lymph node: 14.1 nTPM (protected, limit 3); smooth muscle: 13.4 nTPM (vital, limit 1); thyroid gland: 12.9 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); liver: 12.1 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 3); rectum: 11.3 nTPM (protected, limit 3); spleen: 11.1 nTPM (manageable, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 3); pancreas: 10 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 3); skin: 9.4 nTPM (manageable, limit 5); salivary gland: 9.3 nTPM (protected, limit 3); tongue: 8.9 nTPM (protected, limit 3); small intestine: 8.8 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164944,VIRMA,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.2000% (minimum 95%, Missing); adrenal gland: 50.0000% (minimum 99%, Missing); amygdala: 55.6338% (minimum 99%, Missing); basal ganglia: 56.8345% (minimum 99%, Missing); bone marrow: 80.6122% (minimum 99%, Missing); cerebellum: 43.6464% (minimum 99%, Missing); cerebral cortex: 53.7415% (minimum 99%, Missing); choroid plexus: 56.4286% (minimum 99%, Missing); colon: 58.5185% (minimum 97%, Missing); duodenum: 66.9492% (minimum 99%, Missing); esophagus: 53.3784% (minimum 97%, Missing); heart muscle: 40.5128% (minimum 99%, Missing); hippocampal formation: 54.4828% (minimum 99%, Missing); hypothalamus: 58.5185% (minimum 99%, Missing); kidney: 63.7097% (minimum 99%, Missing); liver: 68.1034% (minimum 99%, Missing); lung: 65.2893% (minimum 99%, Missing); lymph node: 71.1712% (minimum 97%, Missing); midbrain: 56.8345% (minimum 99%, Missing); pancreas: 60.7692% (minimum 99%, Missing); parathyroid gland: 55.6338% (minimum 97%, Missing); pituitary gland: 61.2403% (minimum 99%, Missing); rectum: 65.2893% (minimum 97%, Missing); retina: 56.4286% (minimum 99%, Missing); salivary gland: 64.2276% (minimum 97%, Missing); skeletal muscle: 45.9302% (minimum 99%, Missing); skin: 66.9492% (minimum 95%, Missing); small intestine: 62.6984% (minimum 99%, Missing); smooth muscle: 56.0284% (minimum 99%, Missing); spinal cord: 56.4286% (minimum 99%, Missing); spleen: 66.3866% (minimum 95%, Missing); stomach: 63.2000% (minimum 97%, Missing); thymus: 66.3866% (minimum 95%, Missing); thyroid gland: 64.7541% (minimum 95%, Missing); tongue: 40.9326% (minimum 97%, Missing); urinary bladder: 61.7188% (minimum 97%, Missing)",-0.318,-0.560674,-0.584872,0,80,unavailable,11.6,11.4,4.6,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 2); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); smooth muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); hypothalamus: 5.6 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); urinary bladder: 4.9 nTPM (protected, limit 2); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164975,SNAPC3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.2000% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 55.6338% (minimum 75%, Missing); basal ganglia: 56.8345% (minimum 75%, Missing); cerebellum: 43.6464% (minimum 75%, Missing); cerebral cortex: 53.7415% (minimum 75%, Missing); choroid plexus: 56.4286% (minimum 75%, Missing); colon: 58.5185% (minimum 70%, Missing); duodenum: 66.9492% (minimum 75%, Missing); esophagus: 53.3784% (minimum 70%, Missing); heart muscle: 40.5128% (minimum 75%, Missing); hippocampal formation: 54.4828% (minimum 75%, Missing); hypothalamus: 58.5185% (minimum 75%, Missing); kidney: 63.7097% (minimum 75%, Missing); liver: 68.1034% (minimum 75%, Missing); lung: 65.2893% (minimum 75%, Missing); midbrain: 56.8345% (minimum 75%, Missing); pancreas: 60.7692% (minimum 75%, Missing); parathyroid gland: 55.6338% (minimum 70%, Missing); pituitary gland: 61.2403% (minimum 75%, Missing); rectum: 65.2893% (minimum 70%, Missing); retina: 56.4286% (minimum 75%, Missing); salivary gland: 64.2276% (minimum 70%, Missing); skeletal muscle: 45.9302% (minimum 75%, Missing); small intestine: 62.6984% (minimum 75%, Missing); smooth muscle: 56.0284% (minimum 75%, Missing); spinal cord: 56.4286% (minimum 75%, Missing); stomach: 63.2000% (minimum 70%, Missing); thyroid gland: 64.7541% (minimum 65%, Missing); tongue: 40.9326% (minimum 70%, Missing); urinary bladder: 61.7188% (minimum 70%, Missing)",-0.018,-0.290674,-0.344872,0,80,unavailable,11.6,11.4,4.6,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 2); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); smooth muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); hypothalamus: 5.6 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); urinary bladder: 4.9 nTPM (protected, limit 2); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164975,SNAPC3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.2000% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 55.6338% (minimum 75%, Missing); basal ganglia: 56.8345% (minimum 75%, Missing); cerebellum: 43.6464% (minimum 75%, Missing); cerebral cortex: 53.7415% (minimum 75%, Missing); choroid plexus: 56.4286% (minimum 75%, Missing); colon: 58.5185% (minimum 70%, Missing); duodenum: 66.9492% (minimum 75%, Missing); esophagus: 53.3784% (minimum 70%, Missing); heart muscle: 40.5128% (minimum 75%, Missing); hippocampal formation: 54.4828% (minimum 75%, Missing); hypothalamus: 58.5185% (minimum 75%, Missing); kidney: 63.7097% (minimum 75%, Missing); liver: 68.1034% (minimum 75%, Missing); lung: 65.2893% (minimum 75%, Missing); midbrain: 56.8345% (minimum 75%, Missing); pancreas: 60.7692% (minimum 75%, Missing); parathyroid gland: 55.6338% (minimum 70%, Missing); pituitary gland: 61.2403% (minimum 75%, Missing); rectum: 65.2893% (minimum 70%, Missing); retina: 56.4286% (minimum 75%, Missing); salivary gland: 64.2276% (minimum 70%, Missing); skeletal muscle: 45.9302% (minimum 75%, Missing); small intestine: 62.6984% (minimum 75%, Missing); smooth muscle: 56.0284% (minimum 75%, Missing); spinal cord: 56.4286% (minimum 75%, Missing); stomach: 63.2000% (minimum 70%, Missing); thyroid gland: 64.7541% (minimum 65%, Missing); tongue: 40.9326% (minimum 70%, Missing); urinary bladder: 61.7188% (minimum 70%, Missing)",-0.018,-0.290674,-0.344872,0,80,unavailable,11.6,11.4,4.6,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 3); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); smooth muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); hypothalamus: 5.6 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); urinary bladder: 4.9 nTPM (protected, limit 3); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164975,SNAPC3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.2000% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 55.6338% (minimum 75%, Missing); basal ganglia: 56.8345% (minimum 75%, Missing); cerebellum: 43.6464% (minimum 75%, Missing); cerebral cortex: 53.7415% (minimum 75%, Missing); choroid plexus: 56.4286% (minimum 75%, Missing); colon: 58.5185% (minimum 70%, Missing); duodenum: 66.9492% (minimum 75%, Missing); esophagus: 53.3784% (minimum 70%, Missing); heart muscle: 40.5128% (minimum 75%, Missing); hippocampal formation: 54.4828% (minimum 75%, Missing); hypothalamus: 58.5185% (minimum 75%, Missing); kidney: 63.7097% (minimum 75%, Missing); liver: 68.1034% (minimum 75%, Missing); lung: 65.2893% (minimum 75%, Missing); midbrain: 56.8345% (minimum 75%, Missing); pancreas: 60.7692% (minimum 75%, Missing); parathyroid gland: 55.6338% (minimum 70%, Missing); pituitary gland: 61.2403% (minimum 75%, Missing); rectum: 65.2893% (minimum 70%, Missing); retina: 56.4286% (minimum 75%, Missing); salivary gland: 64.2276% (minimum 70%, Missing); skeletal muscle: 45.9302% (minimum 75%, Missing); small intestine: 62.6984% (minimum 75%, Missing); smooth muscle: 56.0284% (minimum 75%, Missing); spinal cord: 56.4286% (minimum 75%, Missing); stomach: 63.2000% (minimum 70%, Missing); thyroid gland: 64.7541% (minimum 65%, Missing); tongue: 40.9326% (minimum 70%, Missing); urinary bladder: 61.7188% (minimum 70%, Missing)",-0.018,-0.290674,-0.344872,0,80,unavailable,11.6,11.4,4.6,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 3); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); smooth muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); hypothalamus: 5.6 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); urinary bladder: 4.9 nTPM (protected, limit 3); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164975,SNAPC3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.2000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 55.6338% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.8345% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.6464% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.7415% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 56.4286% (minimum 75%, Baseline (adaptation disabled)); colon: 58.5185% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.9492% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.3784% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 40.5128% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.4828% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.5185% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.7097% (minimum 75%, Baseline (adaptation disabled)); liver: 68.1034% (minimum 75%, Baseline (adaptation disabled)); lung: 65.2893% (minimum 75%, Baseline (adaptation disabled)); midbrain: 56.8345% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.7692% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.6338% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 61.2403% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.2893% (minimum 70%, Baseline (adaptation disabled)); retina: 56.4286% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.2276% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 45.9302% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.6984% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.0284% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.4286% (minimum 75%, Baseline (adaptation disabled)); stomach: 63.2000% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 64.7541% (minimum 65%, Baseline (adaptation disabled)); tongue: 40.9326% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.7188% (minimum 70%, Baseline (adaptation disabled))",-0.018,-0.290674,-0.344872,0,80,unavailable,11.6,11.4,4.6,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 3); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); smooth muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); hypothalamus: 5.6 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); urinary bladder: 4.9 nTPM (protected, limit 3); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164975,SNAPC3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.1624% (minimum 95%, Uncertain); adrenal gland: 91.5966% (minimum 99%, Missing); amygdala: 92.3729% (minimum 99%, Missing); basal ganglia: 88.6179% (minimum 99%, Missing); bone marrow: 84.4961% (minimum 99%, Missing); cerebellum: 81.9549% (minimum 99%, Missing); cerebral cortex: 85.8268% (minimum 99%, Missing); choroid plexus: 91.5966% (minimum 99%, Missing); colon: 92.3729% (minimum 97%, Missing); duodenum: 93.9655% (minimum 99%, Missing); esophagus: 92.3729% (minimum 97%, Missing); heart muscle: 91.5966% (minimum 99%, Missing); hippocampal formation: 91.5966% (minimum 99%, Missing); hypothalamus: 91.5966% (minimum 99%, Missing); kidney: 90.8333% (minimum 99%, Missing); liver: 96.4602% (minimum 99%, Missing); lung: 91.5966% (minimum 99%, Missing); lymph node: 91.5966% (minimum 97%, Uncertain); midbrain: 92.3729% (minimum 99%, Missing); pancreas: 90.0826% (minimum 99%, Missing); parathyroid gland: 88.6179% (minimum 97%, Missing); pituitary gland: 91.5966% (minimum 99%, Missing); rectum: 91.5966% (minimum 97%, Missing); retina: 67.7019% (minimum 99%, Missing); salivary gland: 93.9655% (minimum 97%, Missing); skeletal muscle: 93.1624% (minimum 99%, Missing); skin: 83.2061% (minimum 95%, Missing); small intestine: 92.3729% (minimum 99%, Missing); smooth muscle: 77.3050% (minimum 99%, Missing); spinal cord: 89.3443% (minimum 99%, Missing); spleen: 94.7826% (minimum 95%, Missing); stomach: 89.3443% (minimum 97%, Missing); thymus: 69.8718% (minimum 95%, Missing); thyroid gland: 85.1562% (minimum 95%, Missing); tongue: 91.5966% (minimum 97%, Missing); urinary bladder: 93.9655% (minimum 97%, Missing)",-0.251282,-0.0838211,-0.312981,0,0,routine_complete,5.2,1.4,4.7,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164989,CCDC171,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 67.7019% (minimum 75%, Missing)",0.0487179,0.186179,-0.0729814,0,0,routine_complete,5.2,1.4,4.7,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164989,CCDC171,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 67.7019% (minimum 75%, Missing)",0.0487179,0.186179,-0.0729814,0,0,routine_complete,5.2,1.4,4.7,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164989,CCDC171,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 67.7019% (minimum 75%, Missing)",0.0487179,0.186179,-0.0729814,0,0,routine_complete,5.2,1.4,4.7,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164989,CCDC171,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 67.7019% (minimum 75%, Baseline (adaptation disabled))",0.0487179,0.186179,-0.0729814,0,0,routine_complete,5.2,1.4,4.7,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000164989,CCDC171,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165059,PRKACG,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165059,PRKACG,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165059,PRKACG,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165059,PRKACG,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165059,PRKACG,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0401235,0.03,0.00751244,0,2,partial,0.1,0,0.4,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165076,PRSS37,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340123,0.3,0.247512,0,2,partial,0.1,0,0.4,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165076,PRSS37,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340123,0.3,0.247512,0,2,partial,0.1,0,0.4,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165076,PRSS37,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340123,0.3,0.247512,0,2,partial,0.1,0,0.4,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165076,PRSS37,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340123,0.3,0.247512,0,2,partial,0.1,0,0.4,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165076,PRSS37,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 94.1006% (minimum 99%, Missing); basal ganglia: 94.9268% (minimum 99%, Missing); cerebellum: 91.2758% (minimum 99%, Missing); cerebral cortex: 94.9268% (minimum 95%, Enhanced); choroid plexus: 93.0210% (minimum 99%, Missing); colon: 94.3286% (minimum 97%, Missing); duodenum: 97.7398% (minimum 99%, Missing); heart muscle: 93.1100% (minimum 95%, Enhanced); hippocampal formation: 94.8343% (minimum 99%, Missing); hypothalamus: 93.2439% (minimum 99%, Missing); midbrain: 93.1100% (minimum 99%, Missing); pituitary gland: 94.1006% (minimum 99%, Missing); retina: 89.8016% (minimum 99%, Missing); skeletal muscle: 80.0494% (minimum 95%, Enhanced); small intestine: 97.3974% (minimum 99%, Missing); spinal cord: 93.6928% (minimum 99%, Missing); tongue: 88.4144% (minimum 97%, Missing)",0.00626536,-0.0858564,-0.149506,0,14,partial,48.5,25.5,9.6,"skeletal muscle: 48.5 nTPM (vital, limit 6); tongue: 25.5 nTPM (protected, limit 2); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 6); midbrain: 14.4 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 2); hippocampal formation: 10.6 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); liver: 9.2 nTPM (vital, limit 6); thymus: 8.9 nTPM (manageable, limit 5); pancreas: 8.3 nTPM (vital, limit 6); kidney: 7.2 nTPM (vital, limit 6); adrenal gland: 6.3 nTPM (vital, limit 6); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165113,GKAP1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.306265,0.184144,0.148016,0,14,partial,48.5,25.5,9.6,"skeletal muscle: 48.5 nTPM (vital, limit 6); tongue: 25.5 nTPM (protected, limit 2); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 6); midbrain: 14.4 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 2); hippocampal formation: 10.6 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); liver: 9.2 nTPM (vital, limit 6); thymus: 8.9 nTPM (manageable, limit 5); pancreas: 8.3 nTPM (vital, limit 6); kidney: 7.2 nTPM (vital, limit 6); adrenal gland: 6.3 nTPM (vital, limit 6); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165113,GKAP1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.306265,0.184144,0.148016,0,14,partial,48.5,25.5,9.6,"skeletal muscle: 48.5 nTPM (vital, limit 6); tongue: 25.5 nTPM (protected, limit 3); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 6); midbrain: 14.4 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 3); hippocampal formation: 10.6 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); liver: 9.2 nTPM (vital, limit 6); thymus: 8.9 nTPM (manageable, limit 5); pancreas: 8.3 nTPM (vital, limit 6); kidney: 7.2 nTPM (vital, limit 6); adrenal gland: 6.3 nTPM (vital, limit 6); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165113,GKAP1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.306265,0.184144,0.148016,0,14,partial,48.5,25.5,9.6,"skeletal muscle: 48.5 nTPM (vital, limit 6); tongue: 25.5 nTPM (protected, limit 3); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 6); midbrain: 14.4 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 3); hippocampal formation: 10.6 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); liver: 9.2 nTPM (vital, limit 6); thymus: 8.9 nTPM (manageable, limit 5); pancreas: 8.3 nTPM (vital, limit 6); kidney: 7.2 nTPM (vital, limit 6); adrenal gland: 6.3 nTPM (vital, limit 6); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165113,GKAP1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.302987,0.184144,0.0504936,0,14,partial,48.5,25.5,9.6,"skeletal muscle: 48.5 nTPM (vital, limit 1); tongue: 25.5 nTPM (protected, limit 3); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 3); hippocampal formation: 10.6 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 3); thyroid gland: 9.6 nTPM (manageable, limit 5); liver: 9.2 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); pancreas: 8.3 nTPM (vital, limit 1); adipose tissue: 7.7 nTPM (manageable, limit 5); urinary bladder: 7.6 nTPM (protected, limit 3); stomach: 7.4 nTPM (protected, limit 3); kidney: 7.2 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 3); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165113,GKAP1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.0068254,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165120,SSMEM1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246825,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165120,SSMEM1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246825,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165120,SSMEM1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246825,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165120,SSMEM1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246825,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165120,SSMEM1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.5684% (minimum 99%, Missing); spinal cord: 98.0153% (minimum 99%, Missing)",0.0331547,0.0268944,-0.0143161,0,80,unavailable,1.6,0.2,1.1,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165131,LLCFC1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333155,0.296894,0.225684,0,80,unavailable,1.6,0.2,1.1,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165131,LLCFC1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333155,0.296894,0.225684,0,80,unavailable,1.6,0.2,1.1,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165131,LLCFC1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333155,0.296894,0.225684,0,80,unavailable,1.6,0.2,1.1,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165131,LLCFC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333155,0.296894,0.225684,0,80,unavailable,1.6,0.2,1.1,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165131,LLCFC1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.2000% (minimum 99%, Missing); bone marrow: 98.1567% (minimum 99%, Missing); kidney: 90.6383% (minimum 99%, Missing); retina: 97.7064% (minimum 99%, Missing); stomach: 95.0893% (minimum 97%, Missing)",0.0361111,-0.0191071,-0.138,0,80,unavailable,3.7,1.1,0.3,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165181,SHOC1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336111,0.250893,0.102,0,80,unavailable,3.7,1.1,0.3,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165181,SHOC1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336111,0.250893,0.102,0,80,unavailable,3.7,1.1,0.3,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165181,SHOC1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336111,0.250893,0.102,0,80,unavailable,3.7,1.1,0.3,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165181,SHOC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336111,0.250893,0.102,0,80,unavailable,3.7,1.1,0.3,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165181,SHOC1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.4359% (minimum 99%, Missing); amygdala: 97.4359% (minimum 99%, Missing); basal ganglia: 97.4359% (minimum 99%, Missing); choroid plexus: 97.4359% (minimum 99%, Missing); heart muscle: 97.4359% (minimum 99%, Missing); hippocampal formation: 97.4359% (minimum 99%, Missing); hypothalamus: 97.4359% (minimum 99%, Missing); kidney: 95.0000% (minimum 99%, Missing); liver: 97.4359% (minimum 99%, Missing); midbrain: 97.4359% (minimum 99%, Missing); pancreas: 95.0000% (minimum 99%, Missing); parathyroid gland: 95.0000% (minimum 97%, Missing); pituitary gland: 97.4359% (minimum 99%, Missing); retina: 90.4762% (minimum 99%, Missing); skeletal muscle: 92.6829% (minimum 99%, Missing); small intestine: 97.4359% (minimum 99%, Missing); spinal cord: 97.4359% (minimum 99%, Missing); thyroid gland: 92.6829% (minimum 95%, Missing)",-0.0231707,-0.02,-0.0852381,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165182,CXorf58,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.276829,0.25,0.154762,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165182,CXorf58,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.276829,0.25,0.154762,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165182,CXorf58,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.276829,0.25,0.154762,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165182,CXorf58,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.276829,0.25,0.154762,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165182,CXorf58,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.1366% (minimum 99%, Missing); colon: 96.9325% (minimum 97%, Missing); duodenum: 97.5309% (minimum 99%, Missing); esophagus: 76.6990% (minimum 97%, Missing); kidney: 58.5185% (minimum 99%, Missing); liver: 98.7500% (minimum 99%, Missing); lung: 98.1366% (minimum 99%, Missing); pancreas: 98.1366% (minimum 99%, Missing); pituitary gland: 89.2655% (minimum 99%, Missing); retina: 92.9412% (minimum 99%, Missing); salivary gland: 70.5357% (minimum 97%, Missing); small intestine: 98.1366% (minimum 99%, Missing); stomach: 82.7225% (minimum 97%, Missing)",0.0253086,-0.264643,-0.404815,0,80,unavailable,11.2,6.6,0.4,"kidney: 11.2 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); stomach: 3.3 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165188,RNF183,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 58.5185% (minimum 75%, Missing)",0.325309,0.00535714,-0.164815,0,80,unavailable,11.2,6.6,0.4,"kidney: 11.2 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); stomach: 3.3 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165188,RNF183,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 58.5185% (minimum 75%, Missing)",0.325309,0.00535714,-0.164815,0,80,unavailable,11.2,6.6,0.4,"kidney: 11.2 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165188,RNF183,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 58.5185% (minimum 75%, Missing)",0.325309,0.00535714,-0.164815,0,80,unavailable,11.2,6.6,0.4,"kidney: 11.2 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165188,RNF183,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 58.5185% (minimum 75%, Baseline (adaptation disabled))",0.325309,0.00535714,-0.164815,0,80,unavailable,11.2,6.6,0.4,"kidney: 11.2 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165188,RNF183,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165204,OR1K1,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165204,OR1K1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165204,OR1K1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165204,OR1K1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165204,OR1K1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.8219% (minimum 95%, Uncertain); adrenal gland: 90.7692% (minimum 99%, Missing); amygdala: 86.7647% (minimum 99%, Missing); basal ganglia: 78.6667% (minimum 99%, Missing); bone marrow: 18.6120% (minimum 99%, Missing); cerebellum: 83.0986% (minimum 99%, Missing); cerebral cortex: 83.0986% (minimum 99%, Missing); choroid plexus: 95.1613% (minimum 99%, Missing); colon: 67.0455% (minimum 97%, Missing); duodenum: 67.8161% (minimum 99%, Missing); esophagus: 71.9512% (minimum 97%, Missing); heart muscle: 74.6835% (minimum 99%, Missing); hippocampal formation: 84.2857% (minimum 99%, Missing); hypothalamus: 85.5072% (minimum 99%, Missing); kidney: 67.0455% (minimum 99%, Missing); liver: 35.9756% (minimum 99%, Missing); lung: 84.2857% (minimum 99%, Uncertain); lymph node: 57.2816% (minimum 97%, Uncertain); midbrain: 80.8219% (minimum 99%, Missing); pancreas: 81.9444% (minimum 99%, Uncertain); parathyroid gland: 79.7297% (minimum 97%, Missing); pituitary gland: 95.1613% (minimum 99%, Missing); rectum: 64.8352% (minimum 97%, Uncertain); retina: 83.0986% (minimum 99%, Missing); salivary gland: 89.3939% (minimum 97%, Uncertain); skeletal muscle: 80.8219% (minimum 99%, Missing); skin: 63.4409% (minimum 95%, Missing); small intestine: 67.0455% (minimum 99%, Missing); smooth muscle: 71.9512% (minimum 99%, Uncertain); spinal cord: 75.6410% (minimum 99%, Missing); spleen: 81.9444% (minimum 95%, Missing); stomach: 73.7500% (minimum 97%, Missing); thymus: 41.2587% (minimum 95%, Missing); thyroid gland: 84.2857% (minimum 95%, Missing); tongue: 69.4118% (minimum 97%, Missing); urinary bladder: 80.8219% (minimum 97%, Missing)",-0.537413,-0.397184,-0.80388,0,3,partial,25.8,4.4,8.4,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 2); rectum: 3.2 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165244,ZNF367,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 18.6120% (minimum 75%, Missing); colon: 67.0455% (minimum 70%, Missing); duodenum: 67.8161% (minimum 75%, Missing); heart muscle: 74.6835% (minimum 75%, Missing); kidney: 67.0455% (minimum 75%, Missing); liver: 35.9756% (minimum 75%, Missing); lymph node: 57.2816% (minimum 70%, Uncertain); rectum: 64.8352% (minimum 70%, Uncertain); skin: 63.4409% (minimum 65%, Missing); small intestine: 67.0455% (minimum 75%, Missing); smooth muscle: 71.9512% (minimum 75%, Uncertain); thymus: 41.2587% (minimum 65%, Missing); tongue: 69.4118% (minimum 70%, Missing)",-0.237413,-0.127184,-0.56388,0,3,partial,25.8,4.4,8.4,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 2); rectum: 3.2 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165244,ZNF367,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 18.6120% (minimum 75%, Missing); colon: 67.0455% (minimum 70%, Missing); duodenum: 67.8161% (minimum 75%, Missing); heart muscle: 74.6835% (minimum 75%, Missing); kidney: 67.0455% (minimum 75%, Missing); liver: 35.9756% (minimum 75%, Missing); lymph node: 57.2816% (minimum 70%, Uncertain); rectum: 64.8352% (minimum 70%, Uncertain); skin: 63.4409% (minimum 65%, Missing); small intestine: 67.0455% (minimum 75%, Missing); smooth muscle: 71.9512% (minimum 75%, Uncertain); thymus: 41.2587% (minimum 65%, Missing); tongue: 69.4118% (minimum 70%, Missing)",-0.237413,-0.127184,-0.56388,0,3,partial,25.8,4.4,8.4,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 3); rectum: 3.2 nTPM (protected, limit 3); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165244,ZNF367,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 18.6120% (minimum 75%, Missing); colon: 67.0455% (minimum 70%, Missing); duodenum: 67.8161% (minimum 75%, Missing); heart muscle: 74.6835% (minimum 75%, Missing); kidney: 67.0455% (minimum 75%, Missing); liver: 35.9756% (minimum 75%, Missing); lymph node: 57.2816% (minimum 70%, Uncertain); rectum: 64.8352% (minimum 70%, Uncertain); skin: 63.4409% (minimum 65%, Missing); small intestine: 67.0455% (minimum 75%, Missing); smooth muscle: 71.9512% (minimum 75%, Uncertain); thymus: 41.2587% (minimum 65%, Missing); tongue: 69.4118% (minimum 70%, Missing)",-0.237413,-0.127184,-0.56388,0,3,partial,25.8,4.4,8.4,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 3); rectum: 3.2 nTPM (protected, limit 3); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165244,ZNF367,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 18.6120% (minimum 75%, Baseline (adaptation disabled)); colon: 67.0455% (minimum 70%, Baseline (adaptation disabled)); duodenum: 67.8161% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 74.6835% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.0455% (minimum 75%, Baseline (adaptation disabled)); liver: 35.9756% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.2816% (minimum 70%, Baseline (adaptation disabled)); rectum: 64.8352% (minimum 70%, Baseline (adaptation disabled)); skin: 63.4409% (minimum 65%, Baseline (adaptation disabled)); small intestine: 67.0455% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.9512% (minimum 75%, Baseline (adaptation disabled)); thymus: 41.2587% (minimum 65%, Baseline (adaptation disabled)); tongue: 69.4118% (minimum 70%, Baseline (adaptation disabled))",-0.237413,-0.127184,-0.56388,0,3,partial,25.8,4.4,8.4,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 3); rectum: 3.2 nTPM (protected, limit 3); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165244,ZNF367,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.7778% (minimum 99%, Missing); basal ganglia: 92.0940% (minimum 99%, Missing); choroid plexus: 46.2446% (minimum 99%, Missing); hippocampal formation: 93.0886% (minimum 99%, Missing); hypothalamus: 91.5074% (minimum 99%, Missing); lung: 92.6882% (minimum 95%, Enhanced); midbrain: 97.2912% (minimum 99%, Missing); pituitary gland: 97.0721% (minimum 99%, Missing); retina: 98.8532% (minimum 99%, Missing); spinal cord: 97.9545% (minimum 99%, Missing)",0.0476852,0.0276852,-0.527554,0,4,partial,50.1,0.1,0.3,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165309,ARMC3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.2446% (minimum 75%, Missing)",0.347685,0.297685,-0.287554,0,4,partial,50.1,0.1,0.3,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165309,ARMC3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.2446% (minimum 75%, Missing)",0.347685,0.297685,-0.287554,0,4,partial,50.1,0.1,0.3,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165309,ARMC3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.2446% (minimum 75%, Missing)",0.347685,0.297685,-0.287554,0,4,partial,50.1,0.1,0.3,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165309,ARMC3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.2446% (minimum 75%, Baseline (adaptation disabled))",0.343088,0.297685,-0.287554,0,4,partial,50.1,0.1,0.3,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165309,ARMC3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9512% (minimum 99%, Missing); basal ganglia: 98.1481% (minimum 99%, Missing); choroid plexus: 92.4419% (minimum 99%, Missing); hippocampal formation: 98.7578% (minimum 99%, Missing); hypothalamus: 95.2096% (minimum 99%, Missing); kidney: 98.1481% (minimum 99%, Missing); lung: 98.1481% (minimum 99%, Missing); midbrain: 98.7578% (minimum 99%, Missing); pancreas: 95.2096% (minimum 99%, Missing); pituitary gland: 91.9075% (minimum 99%, Missing); spinal cord: 95.2096% (minimum 99%, Missing); thyroid gland: 94.6429% (minimum 95%, Missing)",-0.00357143,0.0114815,-0.0709249,0,80,unavailable,1.4,0.3,0.9,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165325,DEUP1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.296429,0.281481,0.169075,0,80,unavailable,1.4,0.3,0.9,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165325,DEUP1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.296429,0.281481,0.169075,0,80,unavailable,1.4,0.3,0.9,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165325,DEUP1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.296429,0.281481,0.169075,0,80,unavailable,1.4,0.3,0.9,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165325,DEUP1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.296429,0.281481,0.169075,0,80,unavailable,1.4,0.3,0.9,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165325,DEUP1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.5075% (minimum 99%, Missing); choroid plexus: 35.5795% (minimum 99%, Missing); hippocampal formation: 97.7778% (minimum 99%, Missing); hypothalamus: 97.7778% (minimum 99%, Missing); lung: 91.0345% (minimum 95%, Enhanced)",0.05,0.03,-0.634205,0,4,partial,23.9,0.6,0.7,"choroid plexus: 23.9 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165383,LRRC18,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 35.5795% (minimum 75%, Missing)",0.35,0.3,-0.394205,0,4,partial,23.9,0.6,0.7,"choroid plexus: 23.9 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165383,LRRC18,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 35.5795% (minimum 75%, Missing)",0.35,0.3,-0.394205,0,4,partial,23.9,0.6,0.7,"choroid plexus: 23.9 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165383,LRRC18,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 35.5795% (minimum 75%, Missing)",0.35,0.3,-0.394205,0,4,partial,23.9,0.6,0.7,"choroid plexus: 23.9 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165383,LRRC18,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 35.5795% (minimum 75%, Baseline (adaptation disabled))",0.29964,0.256522,-0.394205,0,4,partial,23.9,0.6,0.7,"choroid plexus: 23.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165383,LRRC18,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.3871% (minimum 99%, Missing); basal ganglia: 98.3871% (minimum 99%, Missing); bone marrow: 56.4815% (minimum 98%, Approved); colon: 78.2051% (minimum 95%, Approved); duodenum: 85.9155% (minimum 98%, Approved); esophagus: 77.2152% (minimum 95%, Approved); hippocampal formation: 96.8254% (minimum 99%, Missing); liver: 96.8254% (minimum 98%, Approved); lung: 96.8254% (minimum 98%, Approved); lymph node: 59.2233% (minimum 95%, Approved); midbrain: 98.3871% (minimum 99%, Missing); rectum: 67.7778% (minimum 95%, Approved); skin: 78.2051% (minimum 90%, Approved); small intestine: 75.3086% (minimum 98%, Approved); smooth muscle: 84.7222% (minimum 98%, Approved); spleen: 89.7059% (minimum 90%, Approved); stomach: 85.9155% (minimum 95%, Approved); thymus: 34.0782% (minimum 95%, Missing); urinary bladder: 93.8462% (minimum 95%, Approved)",-0.609218,-0.357767,-0.415185,0,3,partial,4.7,4.2,11.8,"thymus: 11.8 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 2); lymph node: 4.2 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165480,SKA3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 56.4815% (minimum 70%, Approved); lymph node: 59.2233% (minimum 65%, Approved); thymus: 34.0782% (minimum 65%, Missing)",-0.309218,-0.057767,-0.135185,0,3,partial,4.7,4.2,11.8,"thymus: 11.8 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 2); lymph node: 4.2 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165480,SKA3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 56.4815% (minimum 70%, Approved); lymph node: 59.2233% (minimum 65%, Approved); thymus: 34.0782% (minimum 65%, Missing)",-0.309218,-0.057767,-0.135185,0,3,partial,4.7,4.2,11.8,"thymus: 11.8 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 2); lymph node: 4.2 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165480,SKA3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 56.4815% (minimum 70%, Approved); lymph node: 59.2233% (minimum 65%, Approved); thymus: 34.0782% (minimum 65%, Missing)",-0.309218,-0.057767,-0.135185,0,3,partial,4.7,4.2,11.8,"thymus: 11.8 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 2); lymph node: 4.2 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165480,SKA3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 56.4815% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.2233% (minimum 70%, Baseline (adaptation disabled)); rectum: 67.7778% (minimum 70%, Baseline (adaptation disabled)); thymus: 34.0782% (minimum 65%, Baseline (adaptation disabled))",-0.309218,-0.107767,-0.185185,0,3,partial,4.7,4.2,11.8,"thymus: 11.8 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 3); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165480,SKA3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.1739% (minimum 95%, Missing); adrenal gland: 96.3636% (minimum 98%, Approved); amygdala: 98.1481% (minimum 99%, Missing); bone marrow: 57.9235% (minimum 99%, Missing); cerebral cortex: 96.3636% (minimum 98%, Approved); colon: 85.4839% (minimum 97%, Missing); duodenum: 87.6033% (minimum 99%, Missing); esophagus: 79.1045% (minimum 97%, Missing); heart muscle: 95.4955% (minimum 98%, Approved); hippocampal formation: 98.1481% (minimum 99%, Missing); kidney: 96.3636% (minimum 98%, Approved); liver: 90.5983% (minimum 98%, Approved); lung: 76.2590% (minimum 99%, Missing); lymph node: 71.1409% (minimum 97%, Missing); midbrain: 98.1481% (minimum 99%, Missing); pancreas: 92.1739% (minimum 98%, Approved); rectum: 83.4646% (minimum 97%, Missing); retina: 94.6429% (minimum 99%, Missing); salivary gland: 92.9825% (minimum 95%, Approved); skeletal muscle: 92.1739% (minimum 98%, Approved); skin: 82.8125% (minimum 95%, Missing); small intestine: 87.6033% (minimum 99%, Missing); smooth muscle: 85.4839% (minimum 99%, Missing); spinal cord: 98.1481% (minimum 99%, Missing); spleen: 79.1045% (minimum 95%, Missing); stomach: 92.1739% (minimum 97%, Missing); thymus: 67.0886% (minimum 95%, Missing); tongue: 92.1739% (minimum 97%, Missing); urinary bladder: 76.2590% (minimum 97%, Missing)",-0.279114,-0.258591,-0.410765,0,6,partial,7.7,4.3,5.2,"bone marrow: 7.7 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165490,DDIAS,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.9235% (minimum 75%, Missing)",0.0208861,0.0114094,-0.170765,0,6,partial,7.7,4.3,5.2,"bone marrow: 7.7 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165490,DDIAS,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.9235% (minimum 75%, Missing)",0.0208861,0.0114094,-0.170765,0,6,partial,7.7,4.3,5.2,"bone marrow: 7.7 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165490,DDIAS,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.9235% (minimum 75%, Missing)",0.0208861,0.0114094,-0.170765,0,6,partial,7.7,4.3,5.2,"bone marrow: 7.7 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165490,DDIAS,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.9235% (minimum 75%, Baseline (adaptation disabled))",0.0208861,0.0114094,-0.170765,0,6,partial,7.7,4.3,5.2,"bone marrow: 7.7 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165490,DDIAS,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.05,0.00173913,0.00333333,0,80,unavailable,0.6,2.6,0,"rectum: 2.6 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165496,RPL10L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.271739,0.243333,0,80,unavailable,0.6,2.6,0,"rectum: 2.6 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165496,RPL10L,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.271739,0.243333,0,80,unavailable,0.6,2.6,0,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165496,RPL10L,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.271739,0.243333,0,80,unavailable,0.6,2.6,0,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165496,RPL10L,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.271739,0.243333,0,80,unavailable,0.6,2.6,0,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165496,RPL10L,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.3662% (minimum 98%, Approved); amygdala: 95.7143% (minimum 99%, Missing); basal ganglia: 94.3662% (minimum 99%, Missing); bone marrow: 97.1014% (minimum 98%, Approved); cerebral cortex: 97.1014% (minimum 98%, Approved); choroid plexus: 98.5294% (minimum 99%, Missing); duodenum: 95.7143% (minimum 98%, Approved); hippocampal formation: 95.7143% (minimum 99%, Missing); hypothalamus: 95.7143% (minimum 99%, Missing); kidney: 93.0556% (minimum 98%, Approved); liver: 95.7143% (minimum 98%, Approved); lung: 97.1014% (minimum 98%, Approved); lymph node: 93.0556% (minimum 95%, Approved); midbrain: 97.1014% (minimum 99%, Missing); pancreas: 94.3662% (minimum 98%, Approved); pituitary gland: 90.5405% (minimum 99%, Missing); retina: 61.4679% (minimum 99%, Missing); skeletal muscle: 97.1014% (minimum 98%, Approved); small intestine: 95.7143% (minimum 98%, Approved); smooth muscle: 97.1014% (minimum 98%, Approved); spinal cord: 97.1014% (minimum 99%, Missing); thymus: 94.3662% (minimum 95%, Missing)",-0.00633803,-0.0194444,-0.375321,0,3,partial,4.2,0.5,0.6,"retina: 4.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165555,NOXRED1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 61.4679% (minimum 75%, Missing)",0.293662,0.280556,-0.135321,0,3,partial,4.2,0.5,0.6,"retina: 4.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165555,NOXRED1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 61.4679% (minimum 75%, Missing)",0.293662,0.280556,-0.135321,0,3,partial,4.2,0.5,0.6,"retina: 4.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165555,NOXRED1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 61.4679% (minimum 75%, Missing)",0.293662,0.280556,-0.135321,0,3,partial,4.2,0.5,0.6,"retina: 4.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165555,NOXRED1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 61.4679% (minimum 75%, Baseline (adaptation disabled))",0.267808,0.230556,-0.135321,0,3,partial,4.2,0.5,0.6,"retina: 4.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165555,NOXRED1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.8333% (minimum 99%, Missing); amygdala: 96.3351% (minimum 99%, Missing); basal ganglia: 96.3351% (minimum 99%, Missing); bone marrow: 90.1961% (minimum 95%, Enhanced); cerebral cortex: 95.8333% (minimum 99%, Missing); choroid plexus: 96.8421% (minimum 99%, Missing); colon: 93.8776% (minimum 97%, Missing); duodenum: 93.8776% (minimum 99%, Missing); heart muscle: 91.0891% (minimum 95%, Enhanced); hippocampal formation: 96.3351% (minimum 99%, Missing); hypothalamus: 96.8421% (minimum 99%, Missing); kidney: 95.3368% (minimum 99%, Missing); lung: 90.6404% (minimum 95%, Enhanced); midbrain: 96.8421% (minimum 99%, Missing); pancreas: 89.7561% (minimum 95%, Enhanced); pituitary gland: 97.3545% (minimum 99%, Missing); rectum: 94.3590% (minimum 97%, Missing); retina: 84.7926% (minimum 99%, Missing); salivary gland: 94.8454% (minimum 97%, Missing); skeletal muscle: 92.9293% (minimum 95%, Enhanced); skin: 94.3590% (minimum 95%, Missing); small intestine: 94.8454% (minimum 99%, Missing); smooth muscle: 90.1961% (minimum 95%, Enhanced); spinal cord: 97.8723% (minimum 99%, Missing); stomach: 92.4623% (minimum 97%, Missing); thyroid gland: 85.1852% (minimum 95%, Missing); tongue: 95.8333% (minimum 97%, Missing)",-0.0981481,-0.0453769,-0.142074,0,2,partial,3.3,1.5,3.2,"retina: 3.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165568,AKR1E2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.201852,0.224623,0.0979263,0,2,partial,3.3,1.5,3.2,"retina: 3.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165568,AKR1E2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.201852,0.224623,0.0979263,0,2,partial,3.3,1.5,3.2,"retina: 3.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165568,AKR1E2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.201852,0.224623,0.0979263,0,2,partial,3.3,1.5,3.2,"retina: 3.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165568,AKR1E2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.201852,0.224623,0.0979263,0,2,partial,3.3,1.5,3.2,"retina: 3.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165568,AKR1E2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 66.6667% (minimum 97%, Supported); heart muscle: 66.6667% (minimum 97%, Supported); parathyroid gland: 80.0000% (minimum 90%, Supported); spleen: 66.6667% (minimum 80%, Supported); tongue: 80.0000% (minimum 97%, Missing)",-0.133333,-0.17,-0.303333,0,3,partial,0.2,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165583,SSX5,admission_only,True,False,False,False,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.116667,0.1,0.0166667,0,3,partial,0.2,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165583,SSX5,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.116667,0.1,0.0166667,0,3,partial,0.2,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165583,SSX5,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.116667,0.1,0.0166667,0,3,partial,0.2,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165583,SSX5,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 66.6667% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.0166667,0.1,-0.0833333,0,3,partial,0.2,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165583,SSX5,current_fixed,True,False,False,False,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0.1,0,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165584,SSX3,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.1,0,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165584,SSX3,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.1,0,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165584,SSX3,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.1,0,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165584,SSX3,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.334962,0.3,0.242424,0,3,partial,0.1,0,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165584,SSX3,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.8635% (minimum 99%, Missing); basal ganglia: 76.6355% (minimum 99%, Missing); cerebellum: 82.0000% (minimum 99%, Missing); cerebral cortex: 28.2759% (minimum 99%, Missing); choroid plexus: 95.9064% (minimum 99%, Missing); hippocampal formation: 46.5909% (minimum 99%, Missing); hypothalamus: 85.4167% (minimum 99%, Missing); midbrain: 85.8639% (minimum 99%, Missing); pituitary gland: 84.1026% (minimum 99%, Missing); spinal cord: 92.1348% (minimum 99%, Missing)",0.0204142,0.0239394,-0.707241,0,80,unavailable,41.6,0.1,0.5,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165643,SOHLH1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.8635% (minimum 75%, Missing); cerebral cortex: 28.2759% (minimum 75%, Missing); hippocampal formation: 46.5909% (minimum 75%, Missing)",0.320414,0.293939,-0.467241,0,80,unavailable,41.6,0.1,0.5,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165643,SOHLH1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.8635% (minimum 75%, Missing); cerebral cortex: 28.2759% (minimum 75%, Missing); hippocampal formation: 46.5909% (minimum 75%, Missing)",0.320414,0.293939,-0.467241,0,80,unavailable,41.6,0.1,0.5,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165643,SOHLH1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.8635% (minimum 75%, Missing); cerebral cortex: 28.2759% (minimum 75%, Missing); hippocampal formation: 46.5909% (minimum 75%, Missing)",0.320414,0.293939,-0.467241,0,80,unavailable,41.6,0.1,0.5,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165643,SOHLH1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.8635% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 28.2759% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 46.5909% (minimum 75%, Baseline (adaptation disabled))",0.320414,0.293939,-0.467241,0,80,unavailable,41.6,0.1,0.5,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165643,SOHLH1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.0570% (minimum 99%, Missing); basal ganglia: 91.9118% (minimum 99%, Missing); cerebral cortex: 93.2836% (minimum 95%, Enhanced); choroid plexus: 71.6332% (minimum 99%, Missing); hippocampal formation: 94.6970% (minimum 99%, Missing); hypothalamus: 92.9368% (minimum 99%, Missing); kidney: 91.9118% (minimum 99%, Missing); lung: 92.5926% (minimum 95%, Enhanced); midbrain: 96.1538% (minimum 99%, Missing); pituitary gland: 93.6330% (minimum 99%, Missing); retina: 90.5797% (minimum 99%, Missing); spinal cord: 96.8992% (minimum 99%, Missing); thymus: 94.3396% (minimum 95%, Missing)",-0.00660377,0.0220635,-0.273668,0,7,partial,9.9,3,4.6,"choroid plexus: 9.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165695,AK8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 71.6332% (minimum 75%, Missing)",0.293396,0.292063,-0.0336676,0,7,partial,9.9,3,4.6,"choroid plexus: 9.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165695,AK8,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 71.6332% (minimum 75%, Missing)",0.293396,0.292063,-0.0336676,0,7,partial,9.9,3,4.6,"choroid plexus: 9.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165695,AK8,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 71.6332% (minimum 75%, Missing)",0.293396,0.292063,-0.0336676,0,7,partial,9.9,3,4.6,"choroid plexus: 9.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165695,AK8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 71.6332% (minimum 75%, Baseline (adaptation disabled))",0.194595,0.192857,-0.0336676,0,7,partial,9.9,3,4.6,"choroid plexus: 9.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165695,AK8,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.5185% (minimum 95%, Enhanced); amygdala: 89.7328% (minimum 99%, Missing); basal ganglia: 87.8183% (minimum 99%, Missing); cerebellum: 93.6858% (minimum 95%, Enhanced); cerebral cortex: 89.5439% (minimum 95%, Enhanced); choroid plexus: 87.0990% (minimum 99%, Missing); heart muscle: 92.7326% (minimum 95%, Enhanced); hippocampal formation: 89.9225% (minimum 99%, Missing); hypothalamus: 87.3973% (minimum 99%, Missing); kidney: 91.4695% (minimum 95%, Enhanced); lung: 94.6588% (minimum 95%, Enhanced); midbrain: 88.9199% (minimum 99%, Missing); pituitary gland: 91.9308% (minimum 99%, Missing); retina: 94.1697% (minimum 99%, Missing); spinal cord: 88.3657% (minimum 99%, Missing); thymus: 94.3089% (minimum 95%, Missing)",-0.00691057,0.0168523,-0.11901,0,6,partial,18.9,11.1,15.2,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); cerebral cortex: 14.9 nTPM (vital, limit 6); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 6); pituitary gland: 11.2 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 6); cerebellum: 8.6 nTPM (vital, limit 6); retina: 7.9 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); adrenal gland: 7.4 nTPM (vital, limit 6); lung: 7.2 nTPM (vital, limit 6)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165698,SPACA9,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.293089,0.286852,0.12099,0,6,partial,18.9,11.1,15.2,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); cerebral cortex: 14.9 nTPM (vital, limit 6); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 6); pituitary gland: 11.2 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 6); cerebellum: 8.6 nTPM (vital, limit 6); retina: 7.9 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); adrenal gland: 7.4 nTPM (vital, limit 6); lung: 7.2 nTPM (vital, limit 6)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165698,SPACA9,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.293089,0.286852,0.12099,0,6,partial,18.9,11.1,15.2,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); cerebral cortex: 14.9 nTPM (vital, limit 6); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 6); pituitary gland: 11.2 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 6); cerebellum: 8.6 nTPM (vital, limit 6); retina: 7.9 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); adrenal gland: 7.4 nTPM (vital, limit 6); lung: 7.2 nTPM (vital, limit 6)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165698,SPACA9,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.293089,0.286852,0.12099,0,6,partial,18.9,11.1,15.2,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); cerebral cortex: 14.9 nTPM (vital, limit 6); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 6); pituitary gland: 11.2 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 6); cerebellum: 8.6 nTPM (vital, limit 6); retina: 7.9 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); adrenal gland: 7.4 nTPM (vital, limit 6); lung: 7.2 nTPM (vital, limit 6)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165698,SPACA9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.243557,0.219971,0.12099,0,6,partial,18.9,11.1,15.2,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.9 nTPM (vital, limit 1); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 1); skin: 11.5 nTPM (manageable, limit 5); pituitary gland: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 3); heart muscle: 10 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); esophagus: 9.3 nTPM (protected, limit 3); cerebellum: 8.6 nTPM (vital, limit 1); retina: 7.9 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); adrenal gland: 7.4 nTPM (vital, limit 1); lung: 7.2 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 3); urinary bladder: 5.9 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165698,SPACA9,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165805,C12orf50,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165805,C12orf50,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165805,C12orf50,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165805,C12orf50,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165805,C12orf50,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.3607% (minimum 99%, Missing); basal ganglia: 97.2973% (minimum 99%, Missing); choroid plexus: 88.2353% (minimum 99%, Missing); colon: 85.1064% (minimum 97%, Missing); duodenum: 84.9057% (minimum 99%, Missing); hippocampal formation: 97.0350% (minimum 99%, Missing); hypothalamus: 97.2973% (minimum 99%, Missing); kidney: 93.7500% (minimum 95%, Enhanced); midbrain: 96.5147% (minimum 99%, Missing); pancreas: 77.5862% (minimum 95%, Enhanced); pituitary gland: 95.2381% (minimum 99%, Missing); rectum: 86.9565% (minimum 97%, Missing); small intestine: 88.8889% (minimum 99%, Missing); spinal cord: 92.3077% (minimum 99%, Missing)",0.0444751,-0.118936,-0.174138,0,13,partial,10.4,7,1.9,"pancreas: 10.4 nTPM (vital, limit 6); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); rectum: 5.4 nTPM (protected, limit 2); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165807,PPP1R36,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344475,0.151064,0.0990566,0,13,partial,10.4,7,1.9,"pancreas: 10.4 nTPM (vital, limit 6); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); rectum: 5.4 nTPM (protected, limit 2); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165807,PPP1R36,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344475,0.151064,0.0990566,0,13,partial,10.4,7,1.9,"pancreas: 10.4 nTPM (vital, limit 6); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); rectum: 5.4 nTPM (protected, limit 3); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165807,PPP1R36,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344475,0.151064,0.0990566,0,13,partial,10.4,7,1.9,"pancreas: 10.4 nTPM (vital, limit 6); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); rectum: 5.4 nTPM (protected, limit 3); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165807,PPP1R36,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.299868,0.137209,0.0258621,0,13,partial,10.4,7,1.9,"pancreas: 10.4 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 3); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); rectum: 5.4 nTPM (protected, limit 3); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 3); spinal cord: 3 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165807,PPP1R36,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.7480% (minimum 97%, Supported); amygdala: 96.7480% (minimum 99%, Missing); basal ganglia: 97.5410% (minimum 99%, Missing); bone marrow: 95.2000% (minimum 97%, Supported); cerebral cortex: 94.4444% (minimum 97%, Supported); choroid plexus: 16.8079% (minimum 99%, Missing); colon: 14.1667% (minimum 97%, Missing); duodenum: 1.1500% (minimum 99%, Missing); heart muscle: 96.7480% (minimum 97%, Supported); hippocampal formation: 97.5410% (minimum 99%, Missing); kidney: 7.8444% (minimum 99%, Missing); liver: 1.7881% (minimum 99%, Missing); lymph node: 88.8060% (minimum 90%, Supported); pituitary gland: 93.7008% (minimum 99%, Missing); rectum: 25.6466% (minimum 97%, Missing); salivary gland: 87.5000% (minimum 90%, Supported); small intestine: 1.0666% (minimum 99%, Missing); smooth muscle: 88.1481% (minimum 97%, Supported); stomach: 80.9524% (minimum 90%, Supported)",0.0254098,-0.828333,-0.979334,0,5,partial,1103.8,72.1,1.3,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 2); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 2)",duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165828,PRAP1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 16.8079% (minimum 75%, Missing); colon: 14.1667% (minimum 70%, Missing); duodenum: 1.1500% (minimum 75%, Missing); kidney: 7.8444% (minimum 75%, Missing); liver: 1.7881% (minimum 75%, Missing); rectum: 25.6466% (minimum 70%, Missing); small intestine: 1.0666% (minimum 75%, Missing)",0.32541,-0.558333,-0.739334,0,5,partial,1103.8,72.1,1.3,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 2); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 2)",duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165828,PRAP1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 16.8079% (minimum 75%, Missing); colon: 14.1667% (minimum 70%, Missing); duodenum: 1.1500% (minimum 75%, Missing); kidney: 7.8444% (minimum 75%, Missing); liver: 1.7881% (minimum 75%, Missing); rectum: 25.6466% (minimum 70%, Missing); small intestine: 1.0666% (minimum 75%, Missing)",0.32541,-0.558333,-0.739334,0,5,partial,1103.8,72.1,1.3,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 3); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 3)",duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165828,PRAP1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 16.8079% (minimum 75%, Missing); colon: 14.1667% (minimum 70%, Missing); duodenum: 1.1500% (minimum 75%, Missing); kidney: 7.8444% (minimum 75%, Missing); liver: 1.7881% (minimum 75%, Missing); rectum: 25.6466% (minimum 70%, Missing); small intestine: 1.0666% (minimum 75%, Missing)",0.32541,-0.558333,-0.739334,0,5,partial,1103.8,72.1,1.3,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 3); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 3)",duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165828,PRAP1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 16.8079% (minimum 75%, Baseline (adaptation disabled)); colon: 14.1667% (minimum 70%, Baseline (adaptation disabled)); duodenum: 1.1500% (minimum 75%, Baseline (adaptation disabled)); kidney: 7.8444% (minimum 75%, Baseline (adaptation disabled)); liver: 1.7881% (minimum 75%, Baseline (adaptation disabled)); rectum: 25.6466% (minimum 70%, Baseline (adaptation disabled)); small intestine: 1.0666% (minimum 75%, Baseline (adaptation disabled))",0.251515,-0.558333,-0.739334,0,5,partial,1103.8,72.1,1.3,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 3); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 3); smooth muscle: 1.6 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165828,PRAP1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 90.4762% (minimum 99%, Missing)",0.05,0.03,-0.0852381,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165837,ERICH6B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.154762,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165837,ERICH6B,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.154762,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165837,ERICH6B,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.154762,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165837,ERICH6B,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.154762,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165837,ERICH6B,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9738% (minimum 99%, Missing); hypothalamus: 97.9738% (minimum 99%, Missing); kidney: 98.6795% (minimum 99%, Missing); pancreas: 98.6795% (minimum 99%, Missing); pituitary gland: 98.7981% (minimum 99%, Missing)",0.0320789,0.0191697,-0.0102622,0,80,unavailable,1.7,0.9,1.5,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165863,SPMIP5,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.332079,0.28917,0.229738,0,80,unavailable,1.7,0.9,1.5,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165863,SPMIP5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.332079,0.28917,0.229738,0,80,unavailable,1.7,0.9,1.5,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165863,SPMIP5,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.332079,0.28917,0.229738,0,80,unavailable,1.7,0.9,1.5,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165863,SPMIP5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.332079,0.28917,0.229738,0,80,unavailable,1.7,0.9,1.5,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165863,SPMIP5,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Missing); amygdala: 96.5517% (minimum 99%, Missing); basal ganglia: 96.5517% (minimum 99%, Missing); bone marrow: 36.3636% (minimum 99%, Missing); cerebral cortex: 96.5517% (minimum 99%, Missing); colon: 75.6757% (minimum 97%, Missing); duodenum: 80.0000% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 93.3333% (minimum 99%, Missing); hippocampal formation: 96.5517% (minimum 99%, Missing); hypothalamus: 96.5517% (minimum 99%, Missing); kidney: 96.5517% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); lung: 90.3226% (minimum 99%, Missing); lymph node: 65.1163% (minimum 97%, Missing); pancreas: 96.5517% (minimum 99%, Missing); parathyroid gland: 96.5517% (minimum 97%, Missing); pituitary gland: 87.5000% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 93.3333% (minimum 99%, Missing); salivary gland: 93.3333% (minimum 97%, Missing); skin: 71.7949% (minimum 95%, Missing); small intestine: 77.7778% (minimum 99%, Missing); smooth muscle: 90.3226% (minimum 99%, Missing); spleen: 90.3226% (minimum 95%, Missing); stomach: 82.3529% (minimum 97%, Missing); thymus: 25.9259% (minimum 95%, Missing); tongue: 96.5517% (minimum 97%, Missing); urinary bladder: 82.3529% (minimum 97%, Missing)",-0.690741,-0.318837,-0.626364,0,80,unavailable,4.9,1.5,8,"thymus: 8 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165891,E2F7,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.3636% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 65.1163% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); thymus: 25.9259% (minimum 65%, Missing)",-0.390741,-0.0488372,-0.386364,0,80,unavailable,4.9,1.5,8,"thymus: 8 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165891,E2F7,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.3636% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 65.1163% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); thymus: 25.9259% (minimum 65%, Missing)",-0.390741,-0.0488372,-0.386364,0,80,unavailable,4.9,1.5,8,"thymus: 8 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165891,E2F7,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.3636% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 65.1163% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); thymus: 25.9259% (minimum 65%, Missing)",-0.390741,-0.0488372,-0.386364,0,80,unavailable,4.9,1.5,8,"thymus: 8 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165891,E2F7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.3636% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); lymph node: 65.1163% (minimum 70%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 70%, Baseline (adaptation disabled)); thymus: 25.9259% (minimum 65%, Baseline (adaptation disabled))",-0.390741,-0.0488372,-0.386364,0,80,unavailable,4.9,1.5,8,"thymus: 8 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165891,E2F7,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 90.2256% (minimum 99%, Missing); amygdala: 96.7742% (minimum 99%, Missing); basal ganglia: 92.3077% (minimum 99%, Missing); bone marrow: 98.3607% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 99%, Missing); cerebral cortex: 98.3607% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 93.7500% (minimum 97%, Missing); duodenum: 97.5610% (minimum 99%, Missing); esophagus: 96.7742% (minimum 97%, Missing); heart muscle: 98.3607% (minimum 99%, Missing); hippocampal formation: 93.7500% (minimum 99%, Missing); hypothalamus: 93.7500% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 80.5369% (minimum 99%, Missing); lung: 88.8889% (minimum 99%, Missing); lymph node: 96.0000% (minimum 97%, Missing); midbrain: 98.3607% (minimum 99%, Missing); pancreas: 93.7500% (minimum 99%, Missing); pituitary gland: 88.2353% (minimum 99%, Missing); retina: 98.3607% (minimum 99%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); small intestine: 90.9091% (minimum 99%, Missing); spinal cord: 98.3607% (minimum 99%, Missing); spleen: 93.7500% (minimum 95%, Missing); stomach: 95.2381% (minimum 97%, Missing); thymus: 94.4882% (minimum 95%, Missing); thyroid gland: 89.5522% (minimum 95%, Missing); urinary bladder: 91.6031% (minimum 97%, Missing)",-0.0544776,-0.0539695,-0.184631,0,7,partial,2.9,1.1,1.4,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165923,AGBL2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.245522,0.216031,0.0553691,0,7,partial,2.9,1.1,1.4,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165923,AGBL2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.245522,0.216031,0.0553691,0,7,partial,2.9,1.1,1.4,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165923,AGBL2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.245522,0.216031,0.0553691,0,7,partial,2.9,1.1,1.4,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165923,AGBL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.245522,0.216031,0.0553691,0,7,partial,2.9,1.1,1.4,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165923,AGBL2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 30.0000% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); lung: 25.0000% (minimum 99%, Missing); pituitary gland: 33.3333% (minimum 99%, Missing); spinal cord: 27.2727% (minimum 99%, Missing)",0.05,0.03,-0.74,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165970,SLC6A5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 30.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); lung: 25.0000% (minimum 75%, Missing); pituitary gland: 33.3333% (minimum 75%, Missing); spinal cord: 27.2727% (minimum 75%, Missing)",0.35,0.3,-0.5,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165970,SLC6A5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 30.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); lung: 25.0000% (minimum 75%, Missing); pituitary gland: 33.3333% (minimum 75%, Missing); spinal cord: 27.2727% (minimum 75%, Missing)",0.35,0.3,-0.5,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165970,SLC6A5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 30.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); lung: 25.0000% (minimum 75%, Missing); pituitary gland: 33.3333% (minimum 75%, Missing); spinal cord: 27.2727% (minimum 75%, Missing)",0.35,0.3,-0.5,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165970,SLC6A5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 30.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 25.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 33.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 27.2727% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.5,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165970,SLC6A5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.4497% (minimum 99%, Missing); bone marrow: 95.8824% (minimum 99%, Missing); cerebral cortex: 98.7879% (minimum 99%, Missing); kidney: 98.1928% (minimum 99%, Missing); liver: 85.7895% (minimum 99%, Missing); retina: 97.0238% (minimum 99%, Missing); skeletal muscle: 95.8824% (minimum 99%, Missing)",0.00882353,0.0178788,-0.132105,0,80,unavailable,2.7,0.2,0.7,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165972,CCDC38,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308824,0.287879,0.107895,0,80,unavailable,2.7,0.2,0.7,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165972,CCDC38,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308824,0.287879,0.107895,0,80,unavailable,2.7,0.2,0.7,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165972,CCDC38,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308824,0.287879,0.107895,0,80,unavailable,2.7,0.2,0.7,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165972,CCDC38,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308824,0.287879,0.107895,0,80,unavailable,2.7,0.2,0.7,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000165972,CCDC38,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 78.4974% (minimum 99%, Missing); amygdala: 82.5613% (minimum 99%, Missing); basal ganglia: 81.2332% (minimum 99%, Missing); bone marrow: 63.7895% (minimum 95%, Enhanced); cerebellum: 76.3224% (minimum 99%, Missing); cerebral cortex: 83.4711% (minimum 99%, Missing); choroid plexus: 77.4936% (minimum 99%, Missing); colon: 72.1429% (minimum 97%, Missing); duodenum: 83.0137% (minimum 99%, Missing); esophagus: 70.4651% (minimum 97%, Missing); heart muscle: 79.1123% (minimum 99%, Missing); hippocampal formation: 81.6712% (minimum 99%, Missing); hypothalamus: 82.7869% (minimum 99%, Missing); kidney: 72.6619% (minimum 99%, Missing); liver: 69.6552% (minimum 99%, Missing); lung: 74.0831% (minimum 99%, Missing); lymph node: 71.8009% (minimum 97%, Missing); midbrain: 80.5851% (minimum 99%, Missing); pancreas: 73.9024% (minimum 99%, Missing); parathyroid gland: 74.8148% (minimum 97%, Missing); pituitary gland: 78.2946% (minimum 99%, Missing); rectum: 75.5611% (minimum 97%, Missing); retina: 75.7500% (minimum 99%, Missing); salivary gland: 72.4880% (minimum 97%, Missing); skeletal muscle: 76.1307% (minimum 99%, Missing); skin: 67.4833% (minimum 95%, Missing); small intestine: 71.6312% (minimum 99%, Missing); smooth muscle: 82.7869% (minimum 99%, Missing); spinal cord: 77.0992% (minimum 99%, Missing); spleen: 67.0354% (minimum 95%, Missing); stomach: 76.7089% (minimum 97%, Missing); thymus: 69.4954% (minimum 95%, Missing); thyroid gland: 75.5611% (minimum 95%, Missing); tongue: 79.7368% (minimum 97%, Missing); urinary bladder: 71.6312% (minimum 97%, Missing)",-0.279646,-0.265349,-0.312105,0,2,partial,17.2,12.7,14.9,"bone marrow: 17.2 nTPM (vital, limit 6); spleen: 14.9 nTPM (manageable, limit 5); skin: 14.6 nTPM (manageable, limit 5); thymus: 13.3 nTPM (manageable, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 2); urinary bladder: 12 nTPM (protected, limit 2); small intestine: 12 nTPM (vital, limit 1); lymph node: 11.9 nTPM (protected, limit 2); colon: 11.7 nTPM (protected, limit 2); salivary gland: 11.5 nTPM (protected, limit 2); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); thyroid gland: 9.8 nTPM (manageable, limit 5); rectum: 9.8 nTPM (protected, limit 2); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 2); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166024,R3HCC1L,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 72.6619% (minimum 75%, Missing); liver: 69.6552% (minimum 75%, Missing); lung: 74.0831% (minimum 75%, Missing); pancreas: 73.9024% (minimum 75%, Missing); small intestine: 71.6312% (minimum 75%, Missing)",0.020354,0.00465116,-0.0534483,0,2,partial,17.2,12.7,14.9,"bone marrow: 17.2 nTPM (vital, limit 6); spleen: 14.9 nTPM (manageable, limit 5); skin: 14.6 nTPM (manageable, limit 5); thymus: 13.3 nTPM (manageable, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 2); urinary bladder: 12 nTPM (protected, limit 2); small intestine: 12 nTPM (vital, limit 1); lymph node: 11.9 nTPM (protected, limit 2); colon: 11.7 nTPM (protected, limit 2); salivary gland: 11.5 nTPM (protected, limit 2); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); thyroid gland: 9.8 nTPM (manageable, limit 5); rectum: 9.8 nTPM (protected, limit 2); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 2); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166024,R3HCC1L,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 72.6619% (minimum 75%, Missing); liver: 69.6552% (minimum 75%, Missing); lung: 74.0831% (minimum 75%, Missing); pancreas: 73.9024% (minimum 75%, Missing); small intestine: 71.6312% (minimum 75%, Missing)",0.020354,0.00465116,-0.0534483,0,2,partial,17.2,12.7,14.9,"bone marrow: 17.2 nTPM (vital, limit 6); spleen: 14.9 nTPM (manageable, limit 5); skin: 14.6 nTPM (manageable, limit 5); thymus: 13.3 nTPM (manageable, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 3); urinary bladder: 12 nTPM (protected, limit 3); small intestine: 12 nTPM (vital, limit 1); lymph node: 11.9 nTPM (protected, limit 3); colon: 11.7 nTPM (protected, limit 3); salivary gland: 11.5 nTPM (protected, limit 3); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 3); thyroid gland: 9.8 nTPM (manageable, limit 5); rectum: 9.8 nTPM (protected, limit 3); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 3); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166024,R3HCC1L,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 72.6619% (minimum 75%, Missing); liver: 69.6552% (minimum 75%, Missing); lung: 74.0831% (minimum 75%, Missing); pancreas: 73.9024% (minimum 75%, Missing); small intestine: 71.6312% (minimum 75%, Missing)",0.020354,0.00465116,-0.0534483,0,2,partial,17.2,12.7,14.9,"bone marrow: 17.2 nTPM (vital, limit 6); spleen: 14.9 nTPM (manageable, limit 5); skin: 14.6 nTPM (manageable, limit 5); thymus: 13.3 nTPM (manageable, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 3); urinary bladder: 12 nTPM (protected, limit 3); small intestine: 12 nTPM (vital, limit 1); lymph node: 11.9 nTPM (protected, limit 3); colon: 11.7 nTPM (protected, limit 3); salivary gland: 11.5 nTPM (protected, limit 3); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 3); thyroid gland: 9.8 nTPM (manageable, limit 5); rectum: 9.8 nTPM (protected, limit 3); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 3); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166024,R3HCC1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 63.7895% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.6619% (minimum 75%, Baseline (adaptation disabled)); liver: 69.6552% (minimum 75%, Baseline (adaptation disabled)); lung: 74.0831% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.9024% (minimum 75%, Baseline (adaptation disabled)); small intestine: 71.6312% (minimum 75%, Baseline (adaptation disabled))",0.020354,0.00465116,-0.112105,0,2,partial,17.2,12.7,14.9,"bone marrow: 17.2 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); skin: 14.6 nTPM (manageable, limit 5); thymus: 13.3 nTPM (manageable, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 3); adipose tissue: 12.4 nTPM (manageable, limit 5); small intestine: 12 nTPM (vital, limit 1); urinary bladder: 12 nTPM (protected, limit 3); lymph node: 11.9 nTPM (protected, limit 3); colon: 11.7 nTPM (protected, limit 3); salivary gland: 11.5 nTPM (protected, limit 3); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 3); rectum: 9.8 nTPM (protected, limit 3); thyroid gland: 9.8 nTPM (manageable, limit 5); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 3); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166024,R3HCC1L,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166049,PASD1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166049,PASD1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166049,PASD1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166049,PASD1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166049,PASD1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5292% (minimum 90%, Approved); adrenal gland: 63.0841% (minimum 99%, Missing); amygdala: 48.3871% (minimum 99%, Missing); basal ganglia: 45.0000% (minimum 99%, Missing); bone marrow: 95.0704% (minimum 99%, Missing); cerebellum: 71.0526% (minimum 99%, Missing); cerebral cortex: 40.2985% (minimum 99%, Missing); choroid plexus: 83.8509% (minimum 99%, Missing); colon: 55.1020% (minimum 97%, Missing); duodenum: 62.7907% (minimum 98%, Approved); esophagus: 69.5876% (minimum 97%, Missing); heart muscle: 65.5340% (minimum 99%, Missing); hippocampal formation: 51.1364% (minimum 99%, Missing); hypothalamus: 57.9399% (minimum 99%, Missing); kidney: 60.5381% (minimum 99%, Missing); liver: 71.4286% (minimum 99%, Missing); lung: 44.4079% (minimum 99%, Missing); lymph node: 65.8537% (minimum 95%, Approved); midbrain: 54.2169% (minimum 99%, Missing); pancreas: 75.4190% (minimum 99%, Missing); parathyroid gland: 67.1642% (minimum 97%, Missing); pituitary gland: 77.5862% (minimum 99%, Missing); rectum: 56.0166% (minimum 97%, Missing); retina: 65.2174% (minimum 99%, Missing); salivary gland: 71.4286% (minimum 97%, Missing); skeletal muscle: 83.8509% (minimum 99%, Missing); skin: 69.2308% (minimum 95%, Missing); small intestine: 62.5000% (minimum 99%, Missing); smooth muscle: 59.4714% (minimum 98%, Approved); spinal cord: 53.7849% (minimum 99%, Missing); spleen: 60.5381% (minimum 90%, Approved); stomach: 57.4468% (minimum 97%, Missing); thymus: 75.8427% (minimum 95%, Missing); thyroid gland: 30.8924% (minimum 95%, Missing); tongue: 63.6792% (minimum 97%, Missing); urinary bladder: 51.5267% (minimum 97%, Missing)",-0.641076,-0.454733,-0.587015,0,3,partial,20,12.7,30.2,"thyroid gland: 30.2 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 2); adipose tissue: 12.2 nTPM (manageable, limit 10); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 2); rectum: 10.6 nTPM (protected, limit 2); stomach: 10 nTPM (protected, limit 2); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 2); kidney: 8.8 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 2); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 4); parathyroid gland: 6.6 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); liver: 5.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166068,SPRED1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5292% (minimum 60%, Approved); adrenal gland: 63.0841% (minimum 75%, Missing); amygdala: 48.3871% (minimum 75%, Missing); basal ganglia: 45.0000% (minimum 75%, Missing); cerebellum: 71.0526% (minimum 75%, Missing); cerebral cortex: 40.2985% (minimum 75%, Missing); colon: 55.1020% (minimum 70%, Missing); duodenum: 62.7907% (minimum 70%, Approved); esophagus: 69.5876% (minimum 70%, Missing); heart muscle: 65.5340% (minimum 75%, Missing); hippocampal formation: 51.1364% (minimum 75%, Missing); hypothalamus: 57.9399% (minimum 75%, Missing); kidney: 60.5381% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lung: 44.4079% (minimum 75%, Missing); midbrain: 54.2169% (minimum 75%, Missing); parathyroid gland: 67.1642% (minimum 70%, Missing); rectum: 56.0166% (minimum 70%, Missing); retina: 65.2174% (minimum 75%, Missing); small intestine: 62.5000% (minimum 75%, Missing); smooth muscle: 59.4714% (minimum 70%, Approved); spinal cord: 53.7849% (minimum 75%, Missing); stomach: 57.4468% (minimum 70%, Missing); thyroid gland: 30.8924% (minimum 65%, Missing); tongue: 63.6792% (minimum 70%, Missing); urinary bladder: 51.5267% (minimum 70%, Missing)",-0.341076,-0.184733,-0.347015,0,3,partial,20,12.7,30.2,"thyroid gland: 30.2 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 2); adipose tissue: 12.2 nTPM (manageable, limit 10); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 2); rectum: 10.6 nTPM (protected, limit 2); stomach: 10 nTPM (protected, limit 2); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 2); kidney: 8.8 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 2); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 4); parathyroid gland: 6.6 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); liver: 5.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166068,SPRED1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5292% (minimum 60%, Approved); adrenal gland: 63.0841% (minimum 75%, Missing); amygdala: 48.3871% (minimum 75%, Missing); basal ganglia: 45.0000% (minimum 75%, Missing); cerebellum: 71.0526% (minimum 75%, Missing); cerebral cortex: 40.2985% (minimum 75%, Missing); colon: 55.1020% (minimum 70%, Missing); duodenum: 62.7907% (minimum 70%, Approved); esophagus: 69.5876% (minimum 70%, Missing); heart muscle: 65.5340% (minimum 75%, Missing); hippocampal formation: 51.1364% (minimum 75%, Missing); hypothalamus: 57.9399% (minimum 75%, Missing); kidney: 60.5381% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lung: 44.4079% (minimum 75%, Missing); midbrain: 54.2169% (minimum 75%, Missing); parathyroid gland: 67.1642% (minimum 70%, Missing); rectum: 56.0166% (minimum 70%, Missing); retina: 65.2174% (minimum 75%, Missing); small intestine: 62.5000% (minimum 75%, Missing); smooth muscle: 59.4714% (minimum 70%, Approved); spinal cord: 53.7849% (minimum 75%, Missing); stomach: 57.4468% (minimum 70%, Missing); thyroid gland: 30.8924% (minimum 65%, Missing); tongue: 63.6792% (minimum 70%, Missing); urinary bladder: 51.5267% (minimum 70%, Missing)",-0.341076,-0.184733,-0.347015,0,3,partial,20,12.7,30.2,"thyroid gland: 30.2 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 3); adipose tissue: 12.2 nTPM (manageable, limit 10); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 3); rectum: 10.6 nTPM (protected, limit 3); stomach: 10 nTPM (protected, limit 3); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 2); kidney: 8.8 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 2); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 4); parathyroid gland: 6.6 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); liver: 5.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166068,SPRED1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5292% (minimum 60%, Approved); adrenal gland: 63.0841% (minimum 75%, Missing); amygdala: 48.3871% (minimum 75%, Missing); basal ganglia: 45.0000% (minimum 75%, Missing); cerebellum: 71.0526% (minimum 75%, Missing); cerebral cortex: 40.2985% (minimum 75%, Missing); colon: 55.1020% (minimum 70%, Missing); duodenum: 62.7907% (minimum 70%, Approved); esophagus: 69.5876% (minimum 70%, Missing); heart muscle: 65.5340% (minimum 75%, Missing); hippocampal formation: 51.1364% (minimum 75%, Missing); hypothalamus: 57.9399% (minimum 75%, Missing); kidney: 60.5381% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lung: 44.4079% (minimum 75%, Missing); midbrain: 54.2169% (minimum 75%, Missing); parathyroid gland: 67.1642% (minimum 70%, Missing); rectum: 56.0166% (minimum 70%, Missing); retina: 65.2174% (minimum 75%, Missing); small intestine: 62.5000% (minimum 75%, Missing); smooth muscle: 59.4714% (minimum 70%, Approved); spinal cord: 53.7849% (minimum 75%, Missing); stomach: 57.4468% (minimum 70%, Missing); thyroid gland: 30.8924% (minimum 65%, Missing); tongue: 63.6792% (minimum 70%, Missing); urinary bladder: 51.5267% (minimum 70%, Missing)",-0.341076,-0.184733,-0.347015,0,3,partial,20,12.7,30.2,"thyroid gland: 30.2 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 3); adipose tissue: 12.2 nTPM (manageable, limit 10); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 3); rectum: 10.6 nTPM (protected, limit 3); stomach: 10 nTPM (protected, limit 3); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 2); kidney: 8.8 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 2); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 4); parathyroid gland: 6.6 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); liver: 5.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166068,SPRED1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5292% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.0841% (minimum 75%, Baseline (adaptation disabled)); amygdala: 48.3871% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 45.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 71.0526% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 40.2985% (minimum 75%, Baseline (adaptation disabled)); colon: 55.1020% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.7907% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.5876% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.5340% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 51.1364% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 57.9399% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.5381% (minimum 75%, Baseline (adaptation disabled)); liver: 71.4286% (minimum 75%, Baseline (adaptation disabled)); lung: 44.4079% (minimum 75%, Baseline (adaptation disabled)); lymph node: 65.8537% (minimum 70%, Baseline (adaptation disabled)); midbrain: 54.2169% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 67.1642% (minimum 70%, Baseline (adaptation disabled)); rectum: 56.0166% (minimum 70%, Baseline (adaptation disabled)); retina: 65.2174% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.5000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.4714% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.7849% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.5381% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.4468% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 30.8924% (minimum 65%, Baseline (adaptation disabled)); tongue: 63.6792% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.5267% (minimum 70%, Baseline (adaptation disabled))",-0.341076,-0.184733,-0.347015,0,3,partial,20,12.7,30.2,"thyroid gland: 30.2 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 3); adipose tissue: 12.2 nTPM (manageable, limit 5); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 3); rectum: 10.6 nTPM (protected, limit 3); stomach: 10 nTPM (protected, limit 3); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1); kidney: 8.8 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 3); parathyroid gland: 6.6 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166068,SPRED1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.00906191,0,1,partial,0.1,0.6,0,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166069,TMCO5A,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.249062,0,1,partial,0.1,0.6,0,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166069,TMCO5A,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.249062,0,1,partial,0.1,0.6,0,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166069,TMCO5A,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.249062,0,1,partial,0.1,0.6,0,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166069,TMCO5A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.294398,0.249062,0,1,partial,0.1,0.6,0,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166069,TMCO5A,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.3670% (minimum 90%, Approved); adrenal gland: 84.0336% (minimum 99%, Missing); amygdala: 75.1315% (minimum 99%, Missing); basal ganglia: 68.7285% (minimum 99%, Missing); cerebellum: 88.5740% (minimum 99%, Missing); cerebral cortex: 74.2942% (minimum 99%, Missing); choroid plexus: 67.4309% (minimum 99%, Missing); colon: 65.4450% (minimum 97%, Missing); duodenum: 93.2836% (minimum 99%, Missing); esophagus: 82.4402% (minimum 97%, Missing); heart muscle: 76.6284% (minimum 99%, Missing); hippocampal formation: 66.0939% (minimum 99%, Missing); hypothalamus: 75.8725% (minimum 99%, Missing); kidney: 90.0090% (minimum 99%, Missing); liver: 96.8992% (minimum 99%, Missing); lung: 77.7001% (minimum 98%, Approved); lymph node: 92.2509% (minimum 97%, Missing); midbrain: 66.1376% (minimum 99%, Missing); pancreas: 95.2381% (minimum 99%, Missing); parathyroid gland: 85.3971% (minimum 95%, Approved); pituitary gland: 75.5287% (minimum 99%, Missing); rectum: 88.8889% (minimum 95%, Approved); retina: 68.1199% (minimum 99%, Missing); salivary gland: 88.5740% (minimum 95%, Approved); skeletal muscle: 93.6330% (minimum 98%, Approved); skin: 88.8099% (minimum 90%, Approved); small intestine: 82.0345% (minimum 98%, Approved); smooth muscle: 70.7714% (minimum 99%, Missing); spinal cord: 56.4972% (minimum 99%, Missing); spleen: 88.3392% (minimum 95%, Missing); stomach: 82.1693% (minimum 97%, Missing); thymus: 85.3971% (minimum 95%, Missing); thyroid gland: 86.7303% (minimum 95%, Missing); tongue: 87.6424% (minimum 97%, Missing); urinary bladder: 71.2758% (minimum 97%, Missing)",-0.096029,-0.31555,-0.425028,0,6,partial,77,52.8,22.9,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 2); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 2); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 2); adipose tissue: 22.9 nTPM (manageable, limit 10); small intestine: 21.9 nTPM (vital, limit 2); stomach: 21.7 nTPM (protected, limit 2); esophagus: 21.3 nTPM (protected, limit 2); adrenal gland: 19 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 4); thymus: 17.1 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); tongue: 14.1 nTPM (protected, limit 2); spleen: 13.2 nTPM (manageable, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); salivary gland: 12.9 nTPM (protected, limit 4); skin: 12.6 nTPM (manageable, limit 10); rectum: 12.5 nTPM (protected, limit 4); kidney: 11.1 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 2); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166086,JAM3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 68.7285% (minimum 75%, Missing); cerebral cortex: 74.2942% (minimum 75%, Missing); choroid plexus: 67.4309% (minimum 75%, Missing); colon: 65.4450% (minimum 70%, Missing); hippocampal formation: 66.0939% (minimum 75%, Missing); midbrain: 66.1376% (minimum 75%, Missing); retina: 68.1199% (minimum 75%, Missing); smooth muscle: 70.7714% (minimum 75%, Missing); spinal cord: 56.4972% (minimum 75%, Missing)",0.203971,-0.0455497,-0.185028,0,6,partial,77,52.8,22.9,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 2); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 2); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 2); adipose tissue: 22.9 nTPM (manageable, limit 10); small intestine: 21.9 nTPM (vital, limit 2); stomach: 21.7 nTPM (protected, limit 2); esophagus: 21.3 nTPM (protected, limit 2); adrenal gland: 19 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 4); thymus: 17.1 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); tongue: 14.1 nTPM (protected, limit 2); spleen: 13.2 nTPM (manageable, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); salivary gland: 12.9 nTPM (protected, limit 4); skin: 12.6 nTPM (manageable, limit 10); rectum: 12.5 nTPM (protected, limit 4); kidney: 11.1 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 2); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166086,JAM3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 68.7285% (minimum 75%, Missing); cerebral cortex: 74.2942% (minimum 75%, Missing); choroid plexus: 67.4309% (minimum 75%, Missing); colon: 65.4450% (minimum 70%, Missing); hippocampal formation: 66.0939% (minimum 75%, Missing); midbrain: 66.1376% (minimum 75%, Missing); retina: 68.1199% (minimum 75%, Missing); smooth muscle: 70.7714% (minimum 75%, Missing); spinal cord: 56.4972% (minimum 75%, Missing)",0.203971,-0.0455497,-0.185028,0,6,partial,77,52.8,22.9,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 3); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 3); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 2); adipose tissue: 22.9 nTPM (manageable, limit 10); small intestine: 21.9 nTPM (vital, limit 2); stomach: 21.7 nTPM (protected, limit 3); esophagus: 21.3 nTPM (protected, limit 3); adrenal gland: 19 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 4); thymus: 17.1 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); tongue: 14.1 nTPM (protected, limit 3); spleen: 13.2 nTPM (manageable, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); salivary gland: 12.9 nTPM (protected, limit 4); skin: 12.6 nTPM (manageable, limit 10); rectum: 12.5 nTPM (protected, limit 4); kidney: 11.1 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 2); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166086,JAM3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 68.7285% (minimum 75%, Missing); cerebral cortex: 74.2942% (minimum 75%, Missing); choroid plexus: 67.4309% (minimum 75%, Missing); colon: 65.4450% (minimum 70%, Missing); hippocampal formation: 66.0939% (minimum 75%, Missing); midbrain: 66.1376% (minimum 75%, Missing); retina: 68.1199% (minimum 75%, Missing); smooth muscle: 70.7714% (minimum 75%, Missing); spinal cord: 56.4972% (minimum 75%, Missing)",0.203971,-0.0455497,-0.185028,0,6,partial,77,52.8,22.9,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 3); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 3); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 2); adipose tissue: 22.9 nTPM (manageable, limit 10); small intestine: 21.9 nTPM (vital, limit 2); stomach: 21.7 nTPM (protected, limit 3); esophagus: 21.3 nTPM (protected, limit 3); adrenal gland: 19 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 4); thymus: 17.1 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); tongue: 14.1 nTPM (protected, limit 3); spleen: 13.2 nTPM (manageable, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); salivary gland: 12.9 nTPM (protected, limit 4); skin: 12.6 nTPM (manageable, limit 10); rectum: 12.5 nTPM (protected, limit 4); kidney: 11.1 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 2); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166086,JAM3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 68.7285% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.2942% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.4309% (minimum 75%, Baseline (adaptation disabled)); colon: 65.4450% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 66.0939% (minimum 75%, Baseline (adaptation disabled)); midbrain: 66.1376% (minimum 75%, Baseline (adaptation disabled)); retina: 68.1199% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.7714% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.4972% (minimum 75%, Baseline (adaptation disabled))",0.16367,-0.0455497,-0.185028,0,6,partial,77,52.8,22.9,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 3); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 3); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 5); small intestine: 21.9 nTPM (vital, limit 1); stomach: 21.7 nTPM (protected, limit 3); esophagus: 21.3 nTPM (protected, limit 3); adrenal gland: 19 nTPM (vital, limit 1); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 17.1 nTPM (protected, limit 3); thyroid gland: 15.3 nTPM (manageable, limit 5); tongue: 14.1 nTPM (protected, limit 3); spleen: 13.2 nTPM (manageable, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); salivary gland: 12.9 nTPM (protected, limit 3); skin: 12.6 nTPM (manageable, limit 5); rectum: 12.5 nTPM (protected, limit 3); kidney: 11.1 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166086,JAM3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.00847445,0,3,partial,0.2,0.2,0,,,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166118,SPATA19,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248474,0,3,partial,0.2,0.2,0,,,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166118,SPATA19,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248474,0,3,partial,0.2,0.2,0,,,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166118,SPATA19,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248474,0,3,partial,0.2,0.2,0,,,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166118,SPATA19,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.298474,0.248474,0,3,partial,0.2,0.2,0,,,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166118,SPATA19,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166152,C16orf78,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166152,C16orf78,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166152,C16orf78,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166152,C16orf78,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166152,C16orf78,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.8272% (minimum 95%, Missing); adrenal gland: 89.9408% (minimum 99%, Missing); amygdala: 88.8889% (minimum 99%, Missing); basal ganglia: 87.8613% (minimum 99%, Missing); bone marrow: 84.4444% (minimum 99%, Missing); cerebellum: 91.0180% (minimum 99%, Missing); cerebral cortex: 84.4444% (minimum 99%, Missing); choroid plexus: 90.4762% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); duodenum: 89.9408% (minimum 99%, Missing); esophagus: 87.3563% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 86.8571% (minimum 99%, Missing); kidney: 77.9487% (minimum 99%, Missing); liver: 86.3636% (minimum 99%, Missing); lung: 91.5663% (minimum 99%, Missing); lymph node: 91.0180% (minimum 97%, Missing); midbrain: 87.3563% (minimum 99%, Missing); pancreas: 91.0180% (minimum 99%, Missing); parathyroid gland: 86.8571% (minimum 97%, Missing); pituitary gland: 87.8613% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 77.1574% (minimum 99%, Missing); salivary gland: 90.4762% (minimum 97%, Missing); skeletal muscle: 71.3615% (minimum 99%, Missing); skin: 91.0180% (minimum 95%, Missing); small intestine: 91.5663% (minimum 99%, Missing); smooth muscle: 91.0180% (minimum 99%, Missing); spinal cord: 89.9408% (minimum 99%, Missing); spleen: 91.5663% (minimum 95%, Missing); stomach: 88.3721% (minimum 97%, Missing); thymus: 91.0180% (minimum 95%, Missing); thyroid gland: 75.6219% (minimum 95%, Missing); tongue: 73.4300% (minimum 97%, Missing); urinary bladder: 90.4762% (minimum 97%, Missing)",-0.193781,-0.2357,-0.276385,0,1,partial,6.1,5.5,4.9,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 2); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); hypothalamus: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166192,SENP8,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skeletal muscle: 71.3615% (minimum 75%, Missing)",0.106219,0.0342995,-0.036385,0,1,partial,6.1,5.5,4.9,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 2); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); hypothalamus: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166192,SENP8,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skeletal muscle: 71.3615% (minimum 75%, Missing)",0.106219,0.0342995,-0.036385,0,1,partial,6.1,5.5,4.9,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 3); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166192,SENP8,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skeletal muscle: 71.3615% (minimum 75%, Missing)",0.106219,0.0342995,-0.036385,0,1,partial,6.1,5.5,4.9,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 3); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166192,SENP8,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skeletal muscle: 71.3615% (minimum 75%, Baseline (adaptation disabled))",0.106219,0.0342995,-0.036385,0,1,partial,6.1,5.5,4.9,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 3); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166192,SENP8,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.4615% (minimum 95%, Missing); adrenal gland: 46.9388% (minimum 99%, Missing); amygdala: 58.9744% (minimum 99%, Missing); basal ganglia: 32.8571% (minimum 99%, Missing); cerebellum: 31.9444% (minimum 99%, Missing); cerebral cortex: 9.1451% (minimum 99%, Missing); choroid plexus: 93.8776% (minimum 99%, Missing); colon: 80.7018% (minimum 97%, Missing); duodenum: 85.1852% (minimum 99%, Missing); esophagus: 80.7018% (minimum 97%, Missing); heart muscle: 47.4227% (minimum 99%, Missing); hippocampal formation: 53.4884% (minimum 99%, Missing); hypothalamus: 43.8095% (minimum 99%, Missing); kidney: 39.6552% (minimum 99%, Missing); liver: 90.1961% (minimum 99%, Missing); lung: 85.1852% (minimum 99%, Missing); midbrain: 74.1935% (minimum 99%, Missing); pancreas: 58.9744% (minimum 99%, Missing); parathyroid gland: 69.6970% (minimum 97%, Missing); pituitary gland: 45.0980% (minimum 99%, Missing); rectum: 83.6364% (minimum 97%, Missing); retina: 13.5693% (minimum 99%, Missing); salivary gland: 90.1961% (minimum 97%, Missing); skeletal muscle: 97.8723% (minimum 99%, Missing); skin: 86.7925% (minimum 95%, Missing); small intestine: 88.4615% (minimum 99%, Missing); smooth muscle: 79.3103% (minimum 99%, Missing); spinal cord: 83.6364% (minimum 99%, Missing); spleen: 88.4615% (minimum 95%, Missing); stomach: 45.5446% (minimum 97%, Missing); thymus: 76.6667% (minimum 95%, Missing); thyroid gland: 35.6589% (minimum 95%, Missing); urinary bladder: 82.1429% (minimum 97%, Missing)",-0.593411,-0.514554,-0.898549,0,80,unavailable,45.7,5.5,8.3,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166206,GABRB3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 46.9388% (minimum 75%, Missing); amygdala: 58.9744% (minimum 75%, Missing); basal ganglia: 32.8571% (minimum 75%, Missing); cerebellum: 31.9444% (minimum 75%, Missing); cerebral cortex: 9.1451% (minimum 75%, Missing); heart muscle: 47.4227% (minimum 75%, Missing); hippocampal formation: 53.4884% (minimum 75%, Missing); hypothalamus: 43.8095% (minimum 75%, Missing); kidney: 39.6552% (minimum 75%, Missing); midbrain: 74.1935% (minimum 75%, Missing); pancreas: 58.9744% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); pituitary gland: 45.0980% (minimum 75%, Missing); retina: 13.5693% (minimum 75%, Missing); stomach: 45.5446% (minimum 70%, Missing); thyroid gland: 35.6589% (minimum 65%, Missing)",-0.293411,-0.244554,-0.658549,0,80,unavailable,45.7,5.5,8.3,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166206,GABRB3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 46.9388% (minimum 75%, Missing); amygdala: 58.9744% (minimum 75%, Missing); basal ganglia: 32.8571% (minimum 75%, Missing); cerebellum: 31.9444% (minimum 75%, Missing); cerebral cortex: 9.1451% (minimum 75%, Missing); heart muscle: 47.4227% (minimum 75%, Missing); hippocampal formation: 53.4884% (minimum 75%, Missing); hypothalamus: 43.8095% (minimum 75%, Missing); kidney: 39.6552% (minimum 75%, Missing); midbrain: 74.1935% (minimum 75%, Missing); pancreas: 58.9744% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); pituitary gland: 45.0980% (minimum 75%, Missing); retina: 13.5693% (minimum 75%, Missing); stomach: 45.5446% (minimum 70%, Missing); thyroid gland: 35.6589% (minimum 65%, Missing)",-0.293411,-0.244554,-0.658549,0,80,unavailable,45.7,5.5,8.3,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 3); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166206,GABRB3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 46.9388% (minimum 75%, Missing); amygdala: 58.9744% (minimum 75%, Missing); basal ganglia: 32.8571% (minimum 75%, Missing); cerebellum: 31.9444% (minimum 75%, Missing); cerebral cortex: 9.1451% (minimum 75%, Missing); heart muscle: 47.4227% (minimum 75%, Missing); hippocampal formation: 53.4884% (minimum 75%, Missing); hypothalamus: 43.8095% (minimum 75%, Missing); kidney: 39.6552% (minimum 75%, Missing); midbrain: 74.1935% (minimum 75%, Missing); pancreas: 58.9744% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); pituitary gland: 45.0980% (minimum 75%, Missing); retina: 13.5693% (minimum 75%, Missing); stomach: 45.5446% (minimum 70%, Missing); thyroid gland: 35.6589% (minimum 65%, Missing)",-0.293411,-0.244554,-0.658549,0,80,unavailable,45.7,5.5,8.3,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 3); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166206,GABRB3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 46.9388% (minimum 75%, Baseline (adaptation disabled)); amygdala: 58.9744% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 32.8571% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 31.9444% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 9.1451% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 47.4227% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 53.4884% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 43.8095% (minimum 75%, Baseline (adaptation disabled)); kidney: 39.6552% (minimum 75%, Baseline (adaptation disabled)); midbrain: 74.1935% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.9744% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.6970% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 45.0980% (minimum 75%, Baseline (adaptation disabled)); retina: 13.5693% (minimum 75%, Baseline (adaptation disabled)); stomach: 45.5446% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 35.6589% (minimum 65%, Baseline (adaptation disabled))",-0.293411,-0.244554,-0.658549,0,80,unavailable,45.7,5.5,8.3,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 3); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166206,GABRB3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 13.9423% (minimum 95%, Missing)",-0.810577,0.03,0.00509804,0,80,unavailable,0.1,0,125.3,"thymus: 125.3 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166220,TBATA,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 13.9423% (minimum 65%, Missing)",-0.510577,0.3,0.245098,0,80,unavailable,0.1,0,125.3,"thymus: 125.3 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166220,TBATA,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 13.9423% (minimum 65%, Missing)",-0.510577,0.3,0.245098,0,80,unavailable,0.1,0,125.3,"thymus: 125.3 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166220,TBATA,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 13.9423% (minimum 65%, Missing)",-0.510577,0.3,0.245098,0,80,unavailable,0.1,0,125.3,"thymus: 125.3 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166220,TBATA,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 13.9423% (minimum 65%, Baseline (adaptation disabled))",-0.510577,0.3,0.245098,0,80,unavailable,0.1,0,125.3,"thymus: 125.3 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166220,TBATA,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.6902% (minimum 99%, Missing); basal ganglia: 96.7699% (minimum 99%, Missing); choroid plexus: 86.5223% (minimum 99%, Missing); hippocampal formation: 96.9003% (minimum 99%, Missing); hypothalamus: 96.3807% (minimum 99%, Missing); kidney: 97.6902% (minimum 99%, Missing); midbrain: 97.4255% (minimum 99%, Missing); pituitary gland: 94.7299% (minimum 99%, Missing); retina: 97.6902% (minimum 99%, Missing); spinal cord: 98.0900% (minimum 99%, Missing)",0.0417241,0.0149315,-0.124777,0,6,partial,11.2,1.1,1.9,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166246,DNAAF8,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.341724,0.284932,0.115223,0,6,partial,11.2,1.1,1.9,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166246,DNAAF8,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.341724,0.284932,0.115223,0,6,partial,11.2,1.1,1.9,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166246,DNAAF8,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.341724,0.284932,0.115223,0,6,partial,11.2,1.1,1.9,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166246,DNAAF8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.324255,0.284932,0.115223,0,6,partial,11.2,1.1,1.9,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166246,DNAAF8,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.8333% (minimum 95%, Missing); adrenal gland: 64.1509% (minimum 99%, Missing); amygdala: 82.9268% (minimum 99%, Missing); basal ganglia: 80.9524% (minimum 99%, Missing); bone marrow: 70.8333% (minimum 99%, Missing); cerebellum: 85.0000% (minimum 99%, Missing); cerebral cortex: 73.9130% (minimum 99%, Missing); choroid plexus: 60.7143% (minimum 99%, Missing); colon: 68.0000% (minimum 97%, Missing); duodenum: 57.6271% (minimum 99%, Missing); esophagus: 65.3846% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 82.9268% (minimum 99%, Missing); hypothalamus: 79.0698% (minimum 99%, Missing); kidney: 44.7368% (minimum 99%, Missing); liver: 79.0698% (minimum 99%, Missing); lung: 61.8182% (minimum 99%, Missing); lymph node: 73.9130% (minimum 97%, Missing); midbrain: 80.9524% (minimum 99%, Missing); pancreas: 69.3878% (minimum 99%, Missing); parathyroid gland: 36.9565% (minimum 97%, Missing); pituitary gland: 64.1509% (minimum 99%, Missing); rectum: 68.0000% (minimum 97%, Missing); retina: 43.5897% (minimum 99%, Missing); salivary gland: 70.8333% (minimum 97%, Missing); skeletal muscle: 75.5556% (minimum 99%, Missing); skin: 77.2727% (minimum 95%, Missing); small intestine: 72.3404% (minimum 99%, Missing); smooth muscle: 56.6667% (minimum 99%, Missing); spinal cord: 79.0698% (minimum 99%, Missing); spleen: 77.2727% (minimum 95%, Missing); stomach: 69.3878% (minimum 97%, Missing); thymus: 65.3846% (minimum 95%, Missing); thyroid gland: 53.1250% (minimum 95%, Missing); tongue: 77.2727% (minimum 97%, Missing); urinary bladder: 65.3846% (minimum 97%, Missing)",-0.41875,-0.600435,-0.554103,0,1,partial,4.4,5.8,3,"parathyroid gland: 5.8 nTPM (protected, limit 2); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166263,STXBP4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 64.1509% (minimum 75%, Missing); bone marrow: 70.8333% (minimum 75%, Missing); cerebral cortex: 73.9130% (minimum 75%, Missing); choroid plexus: 60.7143% (minimum 75%, Missing); colon: 68.0000% (minimum 70%, Missing); duodenum: 57.6271% (minimum 75%, Missing); esophagus: 65.3846% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 44.7368% (minimum 75%, Missing); lung: 61.8182% (minimum 75%, Missing); pancreas: 69.3878% (minimum 75%, Missing); parathyroid gland: 36.9565% (minimum 70%, Missing); pituitary gland: 64.1509% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 43.5897% (minimum 75%, Missing); small intestine: 72.3404% (minimum 75%, Missing); smooth muscle: 56.6667% (minimum 75%, Missing); stomach: 69.3878% (minimum 70%, Missing); thyroid gland: 53.1250% (minimum 65%, Missing); urinary bladder: 65.3846% (minimum 70%, Missing)",-0.11875,-0.330435,-0.314103,0,1,partial,4.4,5.8,3,"parathyroid gland: 5.8 nTPM (protected, limit 2); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166263,STXBP4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 64.1509% (minimum 75%, Missing); bone marrow: 70.8333% (minimum 75%, Missing); cerebral cortex: 73.9130% (minimum 75%, Missing); choroid plexus: 60.7143% (minimum 75%, Missing); colon: 68.0000% (minimum 70%, Missing); duodenum: 57.6271% (minimum 75%, Missing); esophagus: 65.3846% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 44.7368% (minimum 75%, Missing); lung: 61.8182% (minimum 75%, Missing); pancreas: 69.3878% (minimum 75%, Missing); parathyroid gland: 36.9565% (minimum 70%, Missing); pituitary gland: 64.1509% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 43.5897% (minimum 75%, Missing); small intestine: 72.3404% (minimum 75%, Missing); smooth muscle: 56.6667% (minimum 75%, Missing); stomach: 69.3878% (minimum 70%, Missing); thyroid gland: 53.1250% (minimum 65%, Missing); urinary bladder: 65.3846% (minimum 70%, Missing)",-0.11875,-0.330435,-0.314103,0,1,partial,4.4,5.8,3,"parathyroid gland: 5.8 nTPM (protected, limit 3); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166263,STXBP4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 64.1509% (minimum 75%, Missing); bone marrow: 70.8333% (minimum 75%, Missing); cerebral cortex: 73.9130% (minimum 75%, Missing); choroid plexus: 60.7143% (minimum 75%, Missing); colon: 68.0000% (minimum 70%, Missing); duodenum: 57.6271% (minimum 75%, Missing); esophagus: 65.3846% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 44.7368% (minimum 75%, Missing); lung: 61.8182% (minimum 75%, Missing); pancreas: 69.3878% (minimum 75%, Missing); parathyroid gland: 36.9565% (minimum 70%, Missing); pituitary gland: 64.1509% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 43.5897% (minimum 75%, Missing); small intestine: 72.3404% (minimum 75%, Missing); smooth muscle: 56.6667% (minimum 75%, Missing); stomach: 69.3878% (minimum 70%, Missing); thyroid gland: 53.1250% (minimum 65%, Missing); urinary bladder: 65.3846% (minimum 70%, Missing)",-0.11875,-0.330435,-0.314103,0,1,partial,4.4,5.8,3,"parathyroid gland: 5.8 nTPM (protected, limit 3); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166263,STXBP4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 64.1509% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 70.8333% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.9130% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.7143% (minimum 75%, Baseline (adaptation disabled)); colon: 68.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.6271% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.3846% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); kidney: 44.7368% (minimum 75%, Baseline (adaptation disabled)); lung: 61.8182% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.3878% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 36.9565% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 64.1509% (minimum 75%, Baseline (adaptation disabled)); rectum: 68.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 43.5897% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.3404% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.6667% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.3878% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.1250% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 65.3846% (minimum 70%, Baseline (adaptation disabled))",-0.11875,-0.330435,-0.314103,0,1,partial,4.4,5.8,3,"parathyroid gland: 5.8 nTPM (protected, limit 3); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166263,STXBP4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2036% (minimum 99%, Missing); amygdala: 98.9940% (minimum 99%, Missing); basal ganglia: 98.9940% (minimum 99%, Missing); cerebral cortex: 98.7952% (minimum 99%, Missing); choroid plexus: 98.5972% (minimum 99%, Missing); heart muscle: 98.5972% (minimum 99%, Missing); kidney: 96.0938% (minimum 99%, Missing); liver: 95.1644% (minimum 99%, Missing); midbrain: 98.9940% (minimum 99%, Missing); pancreas: 98.2036% (minimum 99%, Missing); pituitary gland: 98.9940% (minimum 99%, Missing); retina: 94.7977% (minimum 99%, Missing); skeletal muscle: 98.9940% (minimum 99%, Missing); spinal cord: 98.5972% (minimum 99%, Missing)",0.0166012,0.0120359,-0.0420231,0,80,unavailable,2.7,0.9,1.7,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166323,C11orf65,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316601,0.282036,0.197977,0,80,unavailable,2.7,0.9,1.7,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166323,C11orf65,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316601,0.282036,0.197977,0,80,unavailable,2.7,0.9,1.7,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166323,C11orf65,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316601,0.282036,0.197977,0,80,unavailable,2.7,0.9,1.7,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166323,C11orf65,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316601,0.282036,0.197977,0,80,unavailable,2.7,0.9,1.7,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166323,C11orf65,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.00640288,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166329,CCDC182,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246403,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166329,CCDC182,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246403,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166329,CCDC182,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246403,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166329,CCDC182,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246403,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166329,CCDC182,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 61.5385% (minimum 99%, Missing); bone marrow: 16.0000% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 88.8889% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); kidney: 38.0952% (minimum 99%, Missing); liver: 53.3333% (minimum 99%, Missing); lung: 57.1429% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); midbrain: 88.8889% (minimum 99%, Missing); pancreas: 72.7273% (minimum 99%, Missing); parathyroid gland: 57.1429% (minimum 97%, Missing); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 72.7273% (minimum 97%, Missing); retina: 57.1429% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 88.8889% (minimum 99%, Missing); skin: 88.8889% (minimum 95%, Missing); small intestine: 44.4444% (minimum 99%, Missing); smooth muscle: 88.8889% (minimum 99%, Missing); spinal cord: 88.8889% (minimum 99%, Missing); spleen: 22.8571% (minimum 95%, Missing); stomach: 61.5385% (minimum 97%, Missing); thymus: 0.2074% (minimum 95%, Missing); thyroid gland: 25.0000% (minimum 95%, Missing); tongue: 72.7273% (minimum 97%, Missing); urinary bladder: 72.7273% (minimum 97%, Missing)",-0.947926,-0.398571,-0.83,0,80,unavailable,4.2,0.6,385,"thymus: 385 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166349,RAG1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 61.5385% (minimum 75%, Missing); bone marrow: 16.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 38.0952% (minimum 75%, Missing); liver: 53.3333% (minimum 75%, Missing); lung: 57.1429% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 57.1429% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); small intestine: 44.4444% (minimum 75%, Missing); spleen: 22.8571% (minimum 65%, Missing); stomach: 61.5385% (minimum 70%, Missing); thymus: 0.2074% (minimum 65%, Missing); thyroid gland: 25.0000% (minimum 65%, Missing)",-0.647926,-0.128571,-0.59,0,80,unavailable,4.2,0.6,385,"thymus: 385 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166349,RAG1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 61.5385% (minimum 75%, Missing); bone marrow: 16.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 38.0952% (minimum 75%, Missing); liver: 53.3333% (minimum 75%, Missing); lung: 57.1429% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 57.1429% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); small intestine: 44.4444% (minimum 75%, Missing); spleen: 22.8571% (minimum 65%, Missing); stomach: 61.5385% (minimum 70%, Missing); thymus: 0.2074% (minimum 65%, Missing); thyroid gland: 25.0000% (minimum 65%, Missing)",-0.647926,-0.128571,-0.59,0,80,unavailable,4.2,0.6,385,"thymus: 385 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166349,RAG1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 61.5385% (minimum 75%, Missing); bone marrow: 16.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 38.0952% (minimum 75%, Missing); liver: 53.3333% (minimum 75%, Missing); lung: 57.1429% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 57.1429% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); small intestine: 44.4444% (minimum 75%, Missing); spleen: 22.8571% (minimum 65%, Missing); stomach: 61.5385% (minimum 70%, Missing); thymus: 0.2074% (minimum 65%, Missing); thyroid gland: 25.0000% (minimum 65%, Missing)",-0.647926,-0.128571,-0.59,0,80,unavailable,4.2,0.6,385,"thymus: 385 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166349,RAG1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 61.5385% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 16.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); kidney: 38.0952% (minimum 75%, Baseline (adaptation disabled)); liver: 53.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 57.1429% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.7273% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.1429% (minimum 70%, Baseline (adaptation disabled)); retina: 57.1429% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); small intestine: 44.4444% (minimum 75%, Baseline (adaptation disabled)); spleen: 22.8571% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.5385% (minimum 70%, Baseline (adaptation disabled)); thymus: 0.2074% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 25.0000% (minimum 65%, Baseline (adaptation disabled))",-0.647926,-0.128571,-0.59,0,80,unavailable,4.2,0.6,385,"thymus: 385 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166349,RAG1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.6744% (minimum 99%, Missing); heart muscle: 97.6744% (minimum 99%, Missing); lung: 97.6744% (minimum 99%, Missing); retina: 95.4545% (minimum 99%, Missing); skeletal muscle: 97.6744% (minimum 99%, Missing)",0.00454545,0.00674419,-0.0354545,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166351,POTED,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.304545,0.276744,0.204545,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166351,POTED,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.304545,0.276744,0.204545,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166351,POTED,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.304545,0.276744,0.204545,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166351,POTED,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.304545,0.276744,0.204545,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166351,POTED,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5556% (minimum 99%, Missing); amygdala: 98.8506% (minimum 99%, Missing); basal ganglia: 96.6292% (minimum 99%, Missing); bone marrow: 90.5263% (minimum 99%, Missing); cerebellum: 96.6292% (minimum 99%, Missing); cerebral cortex: 90.5263% (minimum 99%, Missing); duodenum: 93.4783% (minimum 99%, Missing); esophagus: 93.4783% (minimum 97%, Missing); heart muscle: 90.5263% (minimum 99%, Missing); hippocampal formation: 97.7273% (minimum 99%, Missing); hypothalamus: 98.8506% (minimum 99%, Missing); kidney: 96.6292% (minimum 99%, Missing); liver: 98.8506% (minimum 99%, Missing); lung: 97.7273% (minimum 99%, Missing); lymph node: 87.7551% (minimum 97%, Missing); midbrain: 98.8506% (minimum 99%, Missing); pancreas: 92.4731% (minimum 99%, Missing); pituitary gland: 97.7273% (minimum 99%, Missing); retina: 85.1485% (minimum 99%, Missing); salivary gland: 92.4731% (minimum 97%, Missing); skeletal muscle: 97.7273% (minimum 99%, Missing); skin: 92.4731% (minimum 95%, Missing); small intestine: 92.4731% (minimum 99%, Missing); spinal cord: 98.8506% (minimum 99%, Missing); spleen: 94.5055% (minimum 95%, Missing); stomach: 96.6292% (minimum 97%, Missing); thyroid gland: 90.5263% (minimum 95%, Missing)",-0.0447368,-0.092449,-0.138515,0,80,unavailable,1.5,1.2,0.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166359,WDR88,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.255263,0.177551,0.101485,0,80,unavailable,1.5,1.2,0.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166359,WDR88,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.255263,0.177551,0.101485,0,80,unavailable,1.5,1.2,0.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166359,WDR88,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.255263,0.177551,0.101485,0,80,unavailable,1.5,1.2,0.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166359,WDR88,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.255263,0.177551,0.101485,0,80,unavailable,1.5,1.2,0.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166359,WDR88,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166368,OR2D2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166368,OR2D2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166368,OR2D2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166368,OR2D2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166368,OR2D2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.9123% (minimum 95%, Missing); adrenal gland: 72.5490% (minimum 99%, Missing); amygdala: 82.2222% (minimum 99%, Missing); basal ganglia: 82.2222% (minimum 99%, Missing); bone marrow: 34.1014% (minimum 99%, Missing); cerebellum: 74.0000% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 63.7931% (minimum 97%, Missing); duodenum: 65.4867% (minimum 99%, Missing); esophagus: 43.0233% (minimum 97%, Missing); heart muscle: 70.4762% (minimum 99%, Missing); hippocampal formation: 82.2222% (minimum 99%, Missing); hypothalamus: 84.0909% (minimum 99%, Missing); kidney: 62.1849% (minimum 99%, Missing); liver: 60.1626% (minimum 99%, Missing); lung: 56.4885% (minimum 99%, Missing); lymph node: 54.4118% (minimum 97%, Missing); midbrain: 83.1461% (minimum 99%, Missing); pancreas: 63.2479% (minimum 99%, Missing); parathyroid gland: 57.8125% (minimum 97%, Missing); pituitary gland: 78.7234% (minimum 99%, Missing); rectum: 59.2000% (minimum 97%, Missing); retina: 55.6391% (minimum 99%, Missing); salivary gland: 62.7119% (minimum 97%, Missing); skeletal muscle: 53.2374% (minimum 99%, Missing); skin: 57.8125% (minimum 95%, Missing); small intestine: 63.2479% (minimum 99%, Missing); smooth muscle: 50.3401% (minimum 99%, Missing); spinal cord: 77.8947% (minimum 99%, Missing); spleen: 50.6849% (minimum 95%, Missing); stomach: 62.1849% (minimum 97%, Missing); thymus: 49.6644% (minimum 95%, Missing); thyroid gland: 56.4885% (minimum 95%, Missing); tongue: 56.9231% (minimum 97%, Missing); urinary bladder: 59.6774% (minimum 97%, Missing)",-0.453356,-0.539767,-0.648986,0,80,unavailable,14.3,9.8,7.5,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 2); thymus: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 2); skin: 5.4 nTPM (manageable, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 2); liver: 4.9 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166439,RNF169,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.9123% (minimum 65%, Missing); adrenal gland: 72.5490% (minimum 75%, Missing); bone marrow: 34.1014% (minimum 75%, Missing); cerebellum: 74.0000% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 63.7931% (minimum 70%, Missing); duodenum: 65.4867% (minimum 75%, Missing); esophagus: 43.0233% (minimum 70%, Missing); heart muscle: 70.4762% (minimum 75%, Missing); kidney: 62.1849% (minimum 75%, Missing); liver: 60.1626% (minimum 75%, Missing); lung: 56.4885% (minimum 75%, Missing); lymph node: 54.4118% (minimum 70%, Missing); pancreas: 63.2479% (minimum 75%, Missing); parathyroid gland: 57.8125% (minimum 70%, Missing); rectum: 59.2000% (minimum 70%, Missing); retina: 55.6391% (minimum 75%, Missing); salivary gland: 62.7119% (minimum 70%, Missing); skeletal muscle: 53.2374% (minimum 75%, Missing); skin: 57.8125% (minimum 65%, Missing); small intestine: 63.2479% (minimum 75%, Missing); smooth muscle: 50.3401% (minimum 75%, Missing); spleen: 50.6849% (minimum 65%, Missing); stomach: 62.1849% (minimum 70%, Missing); thymus: 49.6644% (minimum 65%, Missing); thyroid gland: 56.4885% (minimum 65%, Missing); tongue: 56.9231% (minimum 70%, Missing); urinary bladder: 59.6774% (minimum 70%, Missing)",-0.153356,-0.269767,-0.408986,0,80,unavailable,14.3,9.8,7.5,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 2); thymus: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 2); skin: 5.4 nTPM (manageable, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 2); liver: 4.9 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166439,RNF169,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.9123% (minimum 65%, Missing); adrenal gland: 72.5490% (minimum 75%, Missing); bone marrow: 34.1014% (minimum 75%, Missing); cerebellum: 74.0000% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 63.7931% (minimum 70%, Missing); duodenum: 65.4867% (minimum 75%, Missing); esophagus: 43.0233% (minimum 70%, Missing); heart muscle: 70.4762% (minimum 75%, Missing); kidney: 62.1849% (minimum 75%, Missing); liver: 60.1626% (minimum 75%, Missing); lung: 56.4885% (minimum 75%, Missing); lymph node: 54.4118% (minimum 70%, Missing); pancreas: 63.2479% (minimum 75%, Missing); parathyroid gland: 57.8125% (minimum 70%, Missing); rectum: 59.2000% (minimum 70%, Missing); retina: 55.6391% (minimum 75%, Missing); salivary gland: 62.7119% (minimum 70%, Missing); skeletal muscle: 53.2374% (minimum 75%, Missing); skin: 57.8125% (minimum 65%, Missing); small intestine: 63.2479% (minimum 75%, Missing); smooth muscle: 50.3401% (minimum 75%, Missing); spleen: 50.6849% (minimum 65%, Missing); stomach: 62.1849% (minimum 70%, Missing); thymus: 49.6644% (minimum 65%, Missing); thyroid gland: 56.4885% (minimum 65%, Missing); tongue: 56.9231% (minimum 70%, Missing); urinary bladder: 59.6774% (minimum 70%, Missing)",-0.153356,-0.269767,-0.408986,0,80,unavailable,14.3,9.8,7.5,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 3); thymus: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 3); skin: 5.4 nTPM (manageable, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); urinary bladder: 5 nTPM (protected, limit 3); liver: 4.9 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166439,RNF169,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.9123% (minimum 65%, Missing); adrenal gland: 72.5490% (minimum 75%, Missing); bone marrow: 34.1014% (minimum 75%, Missing); cerebellum: 74.0000% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 63.7931% (minimum 70%, Missing); duodenum: 65.4867% (minimum 75%, Missing); esophagus: 43.0233% (minimum 70%, Missing); heart muscle: 70.4762% (minimum 75%, Missing); kidney: 62.1849% (minimum 75%, Missing); liver: 60.1626% (minimum 75%, Missing); lung: 56.4885% (minimum 75%, Missing); lymph node: 54.4118% (minimum 70%, Missing); pancreas: 63.2479% (minimum 75%, Missing); parathyroid gland: 57.8125% (minimum 70%, Missing); rectum: 59.2000% (minimum 70%, Missing); retina: 55.6391% (minimum 75%, Missing); salivary gland: 62.7119% (minimum 70%, Missing); skeletal muscle: 53.2374% (minimum 75%, Missing); skin: 57.8125% (minimum 65%, Missing); small intestine: 63.2479% (minimum 75%, Missing); smooth muscle: 50.3401% (minimum 75%, Missing); spleen: 50.6849% (minimum 65%, Missing); stomach: 62.1849% (minimum 70%, Missing); thymus: 49.6644% (minimum 65%, Missing); thyroid gland: 56.4885% (minimum 65%, Missing); tongue: 56.9231% (minimum 70%, Missing); urinary bladder: 59.6774% (minimum 70%, Missing)",-0.153356,-0.269767,-0.408986,0,80,unavailable,14.3,9.8,7.5,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 3); thymus: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 3); skin: 5.4 nTPM (manageable, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); urinary bladder: 5 nTPM (protected, limit 3); liver: 4.9 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166439,RNF169,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.9123% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 72.5490% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 34.1014% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); colon: 63.7931% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.4867% (minimum 75%, Baseline (adaptation disabled)); esophagus: 43.0233% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.4762% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.1849% (minimum 75%, Baseline (adaptation disabled)); liver: 60.1626% (minimum 75%, Baseline (adaptation disabled)); lung: 56.4885% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.4118% (minimum 70%, Baseline (adaptation disabled)); pancreas: 63.2479% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.8125% (minimum 70%, Baseline (adaptation disabled)); rectum: 59.2000% (minimum 70%, Baseline (adaptation disabled)); retina: 55.6391% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.7119% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 53.2374% (minimum 75%, Baseline (adaptation disabled)); skin: 57.8125% (minimum 65%, Baseline (adaptation disabled)); small intestine: 63.2479% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 50.3401% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.6849% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.1849% (minimum 70%, Baseline (adaptation disabled)); thymus: 49.6644% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.4885% (minimum 65%, Baseline (adaptation disabled)); tongue: 56.9231% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 59.6774% (minimum 70%, Baseline (adaptation disabled))",-0.153356,-0.269767,-0.408986,0,80,unavailable,14.3,9.8,7.5,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 3); thymus: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 3); skin: 5.4 nTPM (manageable, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); urinary bladder: 5 nTPM (protected, limit 3); liver: 4.9 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166439,RNF169,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Missing); adrenal gland: 93.3333% (minimum 99%, Missing); amygdala: 63.6364% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); cerebellum: 63.6364% (minimum 99%, Missing); cerebral cortex: 38.8889% (minimum 99%, Missing); choroid plexus: 93.3333% (minimum 99%, Missing); colon: 87.5000% (minimum 97%, Missing); duodenum: 93.3333% (minimum 99%, Missing); esophagus: 77.7778% (minimum 97%, Missing); heart muscle: 70.0000% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 56.0000% (minimum 99%, Missing); kidney: 82.3529% (minimum 99%, Missing); liver: 82.3529% (minimum 99%, Missing); lung: 82.3529% (minimum 99%, Missing); lymph node: 93.3333% (minimum 97%, Missing); midbrain: 77.7778% (minimum 99%, Missing); pancreas: 93.3333% (minimum 99%, Missing); parathyroid gland: 73.6842% (minimum 97%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); retina: 58.3333% (minimum 99%, Missing); salivary gland: 82.3529% (minimum 97%, Missing); skin: 70.0000% (minimum 95%, Missing); small intestine: 93.3333% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spinal cord: 82.3529% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Missing); stomach: 93.3333% (minimum 97%, Missing); thyroid gland: 82.3529% (minimum 95%, Missing); tongue: 93.3333% (minimum 97%, Missing); urinary bladder: 87.5000% (minimum 97%, Missing)",-0.25,-0.233158,-0.601111,0,80,unavailable,2.2,0.5,0.6,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166546,BEAN1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 63.6364% (minimum 75%, Missing); cerebellum: 63.6364% (minimum 75%, Missing); cerebral cortex: 38.8889% (minimum 75%, Missing); heart muscle: 70.0000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 56.0000% (minimum 75%, Missing); retina: 58.3333% (minimum 75%, Missing)",0.05,0.0368421,-0.361111,0,80,unavailable,2.2,0.5,0.6,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166546,BEAN1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 63.6364% (minimum 75%, Missing); cerebellum: 63.6364% (minimum 75%, Missing); cerebral cortex: 38.8889% (minimum 75%, Missing); heart muscle: 70.0000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 56.0000% (minimum 75%, Missing); retina: 58.3333% (minimum 75%, Missing)",0.05,0.0368421,-0.361111,0,80,unavailable,2.2,0.5,0.6,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166546,BEAN1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 63.6364% (minimum 75%, Missing); cerebellum: 63.6364% (minimum 75%, Missing); cerebral cortex: 38.8889% (minimum 75%, Missing); heart muscle: 70.0000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 56.0000% (minimum 75%, Missing); retina: 58.3333% (minimum 75%, Missing)",0.05,0.0368421,-0.361111,0,80,unavailable,2.2,0.5,0.6,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166546,BEAN1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 63.6364% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 63.6364% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 38.8889% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 56.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 58.3333% (minimum 75%, Baseline (adaptation disabled))",0.05,0.0368421,-0.361111,0,80,unavailable,2.2,0.5,0.6,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166546,BEAN1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.1327% (minimum 99%, Missing); basal ganglia: 93.0736% (minimum 99%, Missing); cerebral cortex: 96.8468% (minimum 97%, Supported); choroid plexus: 66.7702% (minimum 99%, Missing); hippocampal formation: 94.2982% (minimum 99%, Missing); hypothalamus: 93.4783% (minimum 99%, Missing); kidney: 93.8865% (minimum 97%, Supported); lung: 94.5055% (minimum 97%, Supported); midbrain: 95.1327% (minimum 99%, Missing); parathyroid gland: 89.7704% (minimum 90%, Supported); pituitary gland: 91.8803% (minimum 99%, Missing); retina: 92.2747% (minimum 99%, Missing); spinal cord: 94.5055% (minimum 99%, Missing)",0.0339817,-0.00229645,-0.322298,0,4,partial,21.4,4.9,1.7,"choroid plexus: 21.4 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166578,IQCD,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 66.7702% (minimum 75%, Missing)",0.333982,0.283982,-0.0822981,0,4,partial,21.4,4.9,1.7,"choroid plexus: 21.4 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166578,IQCD,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 66.7702% (minimum 75%, Missing)",0.333982,0.283982,-0.0822981,0,4,partial,21.4,4.9,1.7,"choroid plexus: 21.4 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166578,IQCD,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 66.7702% (minimum 75%, Missing)",0.333982,0.283982,-0.0822981,0,4,partial,21.4,4.9,1.7,"choroid plexus: 21.4 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166578,IQCD,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 66.7702% (minimum 75%, Baseline (adaptation disabled))",0.311969,0.197704,-0.0822981,0,4,partial,21.4,4.9,1.7,"choroid plexus: 21.4 nTPM (vital, limit 1); parathyroid gland: 4.9 nTPM (protected, limit 3); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166578,IQCD,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.3560% (minimum 99%, Missing); liver: 95.5292% (minimum 99%, Missing)",0.0405393,0.019603,-0.034708,0,80,unavailable,9.8,2.2,2,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166743,ACSM1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340539,0.289603,0.205292,0,80,unavailable,9.8,2.2,2,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166743,ACSM1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340539,0.289603,0.205292,0,80,unavailable,9.8,2.2,2,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166743,ACSM1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340539,0.289603,0.205292,0,80,unavailable,9.8,2.2,2,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166743,ACSM1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340539,0.289603,0.205292,0,80,unavailable,9.8,2.2,2,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166743,ACSM1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0492236,0.0292236,0.00883586,0,2,partial,1.4,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166796,LDHC,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349224,0.299224,0.248836,0,2,partial,1.4,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166796,LDHC,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349224,0.299224,0.248836,0,2,partial,1.4,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166796,LDHC,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349224,0.299224,0.248836,0,2,partial,1.4,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166796,LDHC,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348061,0.298448,0.24459,0,2,partial,1.4,0.4,0.5,"liver: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166796,LDHC,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.6989% (minimum 99%, Missing); amygdala: 98.8889% (minimum 99%, Missing); bone marrow: 89.8990% (minimum 99%, Missing); cerebellum: 94.6809% (minimum 99%, Missing); cerebral cortex: 96.7391% (minimum 99%, Missing); choroid plexus: 97.8022% (minimum 99%, Missing); duodenum: 93.6842% (minimum 99%, Missing); heart muscle: 98.8889% (minimum 99%, Missing); hippocampal formation: 98.8889% (minimum 99%, Missing); hypothalamus: 98.8889% (minimum 99%, Missing); kidney: 98.8889% (minimum 99%, Missing); lung: 98.8889% (minimum 99%, Missing); lymph node: 95.6989% (minimum 97%, Missing); pancreas: 96.7391% (minimum 99%, Missing); pituitary gland: 98.8889% (minimum 99%, Missing); retina: 89.0000% (minimum 99%, Missing); skeletal muscle: 98.8889% (minimum 99%, Missing); skin: 90.8163% (minimum 95%, Missing); small intestine: 94.6809% (minimum 99%, Missing); thyroid gland: 94.6809% (minimum 95%, Missing)",-0.0418367,-0.0130108,-0.1,0,80,unavailable,1.1,0.4,0.9,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166800,LDHAL6A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.258163,0.256989,0.14,0,80,unavailable,1.1,0.4,0.9,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166800,LDHAL6A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.258163,0.256989,0.14,0,80,unavailable,1.1,0.4,0.9,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166800,LDHAL6A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.258163,0.256989,0.14,0,80,unavailable,1.1,0.4,0.9,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166800,LDHAL6A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.258163,0.256989,0.14,0,80,unavailable,1.1,0.4,0.9,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166800,LDHAL6A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.3617% (minimum 95%, Missing); adrenal gland: 96.5517% (minimum 99%, Missing); amygdala: 94.9153% (minimum 99%, Missing); basal ganglia: 94.9153% (minimum 99%, Missing); bone marrow: 93.3333% (minimum 99%, Missing); cerebellum: 95.4545% (minimum 99%, Missing); cerebral cortex: 90.3226% (minimum 99%, Missing); choroid plexus: 98.2456% (minimum 99%, Missing); colon: 92.3077% (minimum 97%, Missing); duodenum: 95.4545% (minimum 99%, Missing); esophagus: 94.3820% (minimum 97%, Missing); heart muscle: 94.9153% (minimum 99%, Missing); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); kidney: 96.0000% (minimum 99%, Missing); liver: 98.2456% (minimum 99%, Missing); lung: 93.3333% (minimum 99%, Missing); lymph node: 85.2792% (minimum 97%, Missing); midbrain: 91.8033% (minimum 99%, Missing); pancreas: 98.8235% (minimum 99%, Missing); parathyroid gland: 96.5517% (minimum 97%, Missing); pituitary gland: 98.8235% (minimum 99%, Missing); rectum: 92.8177% (minimum 97%, Missing); retina: 93.8547% (minimum 99%, Missing); skeletal muscle: 98.2456% (minimum 99%, Missing); skin: 94.3820% (minimum 95%, Missing); small intestine: 95.4545% (minimum 99%, Missing); smooth muscle: 90.8108% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 91.3043% (minimum 95%, Missing); stomach: 95.4545% (minimum 97%, Missing); thymus: 83.1683% (minimum 95%, Missing); thyroid gland: 94.9153% (minimum 95%, Missing); tongue: 93.8547% (minimum 97%, Missing); urinary bladder: 94.9153% (minimum 97%, Missing)",-0.118317,-0.117208,-0.115,0,80,unavailable,2.4,2.9,3.4,"lymph node: 2.9 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166845,C18orf54,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.181683,0.152792,0.125,0,80,unavailable,2.4,2.9,3.4,"lymph node: 2.9 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166845,C18orf54,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.181683,0.152792,0.125,0,80,unavailable,2.4,2.9,3.4,"spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166845,C18orf54,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.181683,0.152792,0.125,0,80,unavailable,2.4,2.9,3.4,"spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166845,C18orf54,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.181683,0.152792,0.125,0,80,unavailable,2.4,2.9,3.4,"spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166845,C18orf54,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.5357% (minimum 99%, Missing); amygdala: 95.5357% (minimum 99%, Missing); basal ganglia: 93.5860% (minimum 99%, Missing); bone marrow: 50.3925% (minimum 99%, Missing); cerebellum: 91.4530% (minimum 99%, Missing); cerebral cortex: 94.6903% (minimum 99%, Missing); choroid plexus: 97.8659% (minimum 99%, Missing); colon: 77.5362% (minimum 97%, Missing); duodenum: 76.0664% (minimum 99%, Missing); esophagus: 70.3947% (minimum 97%, Missing); heart muscle: 96.9789% (minimum 99%, Missing); hippocampal formation: 95.5357% (minimum 99%, Missing); hypothalamus: 96.1078% (minimum 99%, Missing); kidney: 95.8209% (minimum 99%, Missing); liver: 94.6903% (minimum 99%, Missing); lung: 94.4118% (minimum 99%, Missing); lymph node: 54.1315% (minimum 97%, Missing); midbrain: 96.3964% (minimum 99%, Missing); pancreas: 96.6867% (minimum 99%, Missing); pituitary gland: 96.3964% (minimum 99%, Missing); rectum: 76.6110% (minimum 97%, Missing); retina: 96.3964% (minimum 99%, Missing); salivary gland: 93.3140% (minimum 97%, Missing); skeletal muscle: 97.2727% (minimum 99%, Missing); skin: 85.1459% (minimum 95%, Missing); small intestine: 78.2927% (minimum 99%, Missing); smooth muscle: 89.4150% (minimum 99%, Missing); spinal cord: 96.6867% (minimum 99%, Missing); spleen: 78.2927% (minimum 90%, Approved); stomach: 84.2520% (minimum 97%, Missing); thymus: 42.9144% (minimum 95%, Missing); urinary bladder: 92.2414% (minimum 97%, Missing)",-0.520856,-0.428685,-0.486075,0,4,partial,31.6,27.2,42.7,"thymus: 42.7 nTPM (manageable, limit 5); bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 2); esophagus: 13.5 nTPM (protected, limit 2); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 2); colon: 9.3 nTPM (protected, limit 2); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); skin: 5.6 nTPM (manageable, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166851,PLK1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 50.3925% (minimum 75%, Missing); lymph node: 54.1315% (minimum 70%, Missing); thymus: 42.9144% (minimum 65%, Missing)",-0.220856,-0.158685,-0.246075,0,4,partial,31.6,27.2,42.7,"thymus: 42.7 nTPM (manageable, limit 5); bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 2); esophagus: 13.5 nTPM (protected, limit 2); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 2); colon: 9.3 nTPM (protected, limit 2); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); skin: 5.6 nTPM (manageable, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166851,PLK1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 50.3925% (minimum 75%, Missing); lymph node: 54.1315% (minimum 70%, Missing); thymus: 42.9144% (minimum 65%, Missing)",-0.220856,-0.158685,-0.246075,0,4,partial,31.6,27.2,42.7,"thymus: 42.7 nTPM (manageable, limit 5); bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 3); esophagus: 13.5 nTPM (protected, limit 3); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 3); colon: 9.3 nTPM (protected, limit 3); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); skin: 5.6 nTPM (manageable, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166851,PLK1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 50.3925% (minimum 75%, Missing); lymph node: 54.1315% (minimum 70%, Missing); thymus: 42.9144% (minimum 65%, Missing)",-0.220856,-0.158685,-0.246075,0,4,partial,31.6,27.2,42.7,"thymus: 42.7 nTPM (manageable, limit 5); bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 3); esophagus: 13.5 nTPM (protected, limit 3); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 3); colon: 9.3 nTPM (protected, limit 3); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); skin: 5.6 nTPM (manageable, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166851,PLK1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 50.3925% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.1315% (minimum 70%, Baseline (adaptation disabled)); thymus: 42.9144% (minimum 65%, Baseline (adaptation disabled))",-0.220856,-0.158685,-0.246075,0,4,partial,31.6,27.2,42.7,"thymus: 42.7 nTPM (manageable, limit 5); bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 3); esophagus: 13.5 nTPM (protected, limit 3); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 3); colon: 9.3 nTPM (protected, limit 3); spleen: 8.9 nTPM (manageable, limit 5); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); skin: 5.6 nTPM (manageable, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166851,PLK1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000166884,OR4D6,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000166884,OR4D6,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000166884,OR4D6,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000166884,OR4D6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000166884,OR4D6,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 90.8676% (minimum 95%, Missing); lung: 97.0732% (minimum 99%, Missing); spleen: 85.0427% (minimum 95%, Missing)",-0.0995726,0.0200498,-0.0192683,0,80,unavailable,0.6,0.2,3.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166926,MS4A6E,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.200427,0.29005,0.220732,0,80,unavailable,0.6,0.2,3.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166926,MS4A6E,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.200427,0.29005,0.220732,0,80,unavailable,0.6,0.2,3.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166926,MS4A6E,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.200427,0.29005,0.220732,0,80,unavailable,0.6,0.2,3.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166926,MS4A6E,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.200427,0.29005,0.220732,0,80,unavailable,0.6,0.2,3.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166926,MS4A6E,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.5275% (minimum 99%, Missing); basal ganglia: 98.2019% (minimum 99%, Missing); choroid plexus: 93.7913% (minimum 99%, Missing); hippocampal formation: 96.9945% (minimum 99%, Missing); hypothalamus: 97.1272% (minimum 99%, Missing); lung: 85.9564% (minimum 95%, Enhanced); midbrain: 96.5986% (minimum 99%, Missing); pituitary gland: 98.0663% (minimum 99%, Missing); spinal cord: 94.6667% (minimum 99%, Missing)",0.0457924,0.0257924,-0.0904358,0,1,partial,11.6,2.6,10.2,"lung: 11.6 nTPM (vital, limit 6); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166928,MS4A14,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345792,0.295792,0.187913,0,1,partial,11.6,2.6,10.2,"lung: 11.6 nTPM (vital, limit 6); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166928,MS4A14,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345792,0.295792,0.187913,0,1,partial,11.6,2.6,10.2,"lung: 11.6 nTPM (vital, limit 6); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166928,MS4A14,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345792,0.295792,0.187913,0,1,partial,11.6,2.6,10.2,"lung: 11.6 nTPM (vital, limit 6); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166928,MS4A14,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.224384,0.264674,0.109564,0,1,partial,11.6,2.6,10.2,"lung: 11.6 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166928,MS4A14,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.0054023,0,0,routine_complete,0.2,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166930,MS4A5,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245402,0,0,routine_complete,0.2,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166930,MS4A5,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245402,0,0,routine_complete,0.2,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166930,MS4A5,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245402,0,0,routine_complete,0.2,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166930,MS4A5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245402,0,0,routine_complete,0.2,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000166930,MS4A5,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 91.8103% (minimum 99%, Missing)",0.05,0.03,-0.0718966,0,80,unavailable,1.9,0,0,"liver: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167014,TERB2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.168103,0,80,unavailable,1.9,0,0,"liver: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167014,TERB2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.168103,0,80,unavailable,1.9,0,0,"liver: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167014,TERB2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.168103,0,80,unavailable,1.9,0,0,"liver: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167014,TERB2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.168103,0,80,unavailable,1.9,0,0,"liver: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167014,TERB2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.7261% (minimum 99%, Missing); choroid plexus: 93.3735% (minimum 99%, Missing); hippocampal formation: 98.7261% (minimum 99%, Missing); hypothalamus: 98.7261% (minimum 99%, Missing); lung: 95.6790% (minimum 99%, Missing)",0.0435897,0.00484277,-0.0562651,0,80,unavailable,1.1,0.4,0.1,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167094,TTC16,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34359,0.274843,0.183735,0,80,unavailable,1.1,0.4,0.1,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167094,TTC16,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34359,0.274843,0.183735,0,80,unavailable,1.1,0.4,0.1,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167094,TTC16,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34359,0.274843,0.183735,0,80,unavailable,1.1,0.4,0.1,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167094,TTC16,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34359,0.274843,0.183735,0,80,unavailable,1.1,0.4,0.1,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167094,TTC16,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167098,SUN5,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167098,SUN5,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167098,SUN5,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167098,SUN5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167098,SUN5,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167139,TBC1D21,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167139,TBC1D21,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167139,TBC1D21,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167139,TBC1D21,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167139,TBC1D21,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.5466% (minimum 99%, Missing); amygdala: 97.3856% (minimum 99%, Missing); basal ganglia: 98.0263% (minimum 99%, Missing); bone marrow: 98.0263% (minimum 99%, Missing); cerebellum: 93.1250% (minimum 99%, Missing); cerebral cortex: 88.6905% (minimum 99%, Missing); hippocampal formation: 96.7532% (minimum 99%, Missing); hypothalamus: 98.0263% (minimum 99%, Missing); midbrain: 98.6755% (minimum 99%, Missing); pituitary gland: 98.0263% (minimum 99%, Missing); retina: 30.0403% (minimum 99%, Missing)",0.05,0.0233333,-0.689597,0,80,unavailable,34.7,0.1,0,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167194,C16orf92,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 30.0403% (minimum 75%, Missing)",0.35,0.293333,-0.449597,0,80,unavailable,34.7,0.1,0,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167194,C16orf92,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 30.0403% (minimum 75%, Missing)",0.35,0.293333,-0.449597,0,80,unavailable,34.7,0.1,0,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167194,C16orf92,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 30.0403% (minimum 75%, Missing)",0.35,0.293333,-0.449597,0,80,unavailable,34.7,0.1,0,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167194,C16orf92,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 30.0403% (minimum 75%, Baseline (adaptation disabled))",0.35,0.293333,-0.449597,0,80,unavailable,34.7,0.1,0,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167194,C16orf92,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 72.3881% (minimum 97%, Supported); retina: 95.0980% (minimum 99%, Missing); skeletal muscle: 89.8148% (minimum 97%, Supported)",0.05,0.0197959,-0.246119,0,1,partial,3.7,0.1,0.2,"liver: 3.7 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167195,GOLGA6C,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.289796,0.0738806,0,1,partial,3.7,0.1,0.2,"liver: 3.7 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167195,GOLGA6C,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.289796,0.0738806,0,1,partial,3.7,0.1,0.2,"liver: 3.7 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167195,GOLGA6C,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.289796,0.0738806,0,1,partial,3.7,0.1,0.2,"liver: 3.7 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167195,GOLGA6C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 72.3881% (minimum 75%, Baseline (adaptation disabled))",0.329798,0.289796,-0.0261194,0,1,partial,3.7,0.1,0.2,"liver: 3.7 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167195,GOLGA6C,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.0204% (minimum 95%, Missing); basal ganglia: 93.3054% (minimum 99%, Missing); bone marrow: 88.8446% (minimum 99%, Missing); cerebral cortex: 98.2379% (minimum 99%, Missing); choroid plexus: 98.6726% (minimum 99%, Missing); heart muscle: 96.5368% (minimum 99%, Missing); kidney: 76.8966% (minimum 99%, Missing); lung: 96.1207% (minimum 99%, Missing); pituitary gland: 92.5311% (minimum 99%, Missing); skeletal muscle: 96.9565% (minimum 99%, Missing)",-0.0397959,0.0211111,-0.221034,0,80,unavailable,6.7,0.2,2.2,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167210,LOXHD1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.260204,0.291111,0.0189655,0,80,unavailable,6.7,0.2,2.2,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167210,LOXHD1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.260204,0.291111,0.0189655,0,80,unavailable,6.7,0.2,2.2,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167210,LOXHD1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.260204,0.291111,0.0189655,0,80,unavailable,6.7,0.2,2.2,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167210,LOXHD1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.260204,0.291111,0.0189655,0,80,unavailable,6.7,0.2,2.2,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167210,LOXHD1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.9619% (minimum 99%, Missing); choroid plexus: 91.0828% (minimum 99%, Missing); heart muscle: 94.3894% (minimum 99%, Missing); hypothalamus: 98.9619% (minimum 99%, Missing); kidney: 97.2789% (minimum 99%, Missing); liver: 97.2789% (minimum 99%, Missing); lung: 97.2789% (minimum 99%, Missing); pancreas: 98.9619% (minimum 99%, Missing); parathyroid gland: 91.0828% (minimum 97%, Missing); pituitary gland: 97.6109% (minimum 99%, Missing); retina: 97.9452% (minimum 99%, Missing); salivary gland: 95.0166% (minimum 97%, Missing); skeletal muscle: 68.7500% (minimum 99%, Missing); smooth muscle: 96.6216% (minimum 99%, Missing); thyroid gland: 91.3738% (minimum 95%, Missing); tongue: 74.0933% (minimum 97%, Missing)",-0.036262,-0.229067,-0.3025,0,80,unavailable,13,10,2.7,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167311,ART5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 68.7500% (minimum 75%, Missing)",0.263738,0.0409326,-0.0625,0,80,unavailable,13,10,2.7,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167311,ART5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 68.7500% (minimum 75%, Missing)",0.263738,0.0409326,-0.0625,0,80,unavailable,13,10,2.7,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 3); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167311,ART5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 68.7500% (minimum 75%, Missing)",0.263738,0.0409326,-0.0625,0,80,unavailable,13,10,2.7,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 3); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167311,ART5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 68.7500% (minimum 75%, Baseline (adaptation disabled))",0.263738,0.0409326,-0.0625,0,80,unavailable,13,10,2.7,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 3); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167311,ART5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167360,OR51Q1,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167360,OR51Q1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167360,OR51Q1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167360,OR51Q1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167360,OR51Q1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.2308% (minimum 95%, Missing); adrenal gland: 65.2542% (minimum 99%, Missing); amygdala: 58.3333% (minimum 99%, Missing); basal ganglia: 57.8947% (minimum 99%, Missing); bone marrow: 64.1667% (minimum 99%, Missing); cerebellum: 42.3077% (minimum 99%, Missing); cerebral cortex: 54.6099% (minimum 99%, Missing); choroid plexus: 33.3333% (minimum 99%, Missing); colon: 58.7786% (minimum 97%, Missing); duodenum: 72.6415% (minimum 99%, Missing); esophagus: 65.8120% (minimum 97%, Missing); heart muscle: 60.6299% (minimum 99%, Missing); hippocampal formation: 55.3957% (minimum 99%, Missing); hypothalamus: 56.2044% (minimum 99%, Missing); kidney: 58.3333% (minimum 99%, Missing); liver: 59.6899% (minimum 99%, Missing); lung: 59.6899% (minimum 99%, Missing); lymph node: 56.2044% (minimum 97%, Missing); midbrain: 61.1111% (minimum 99%, Missing); pancreas: 63.6364% (minimum 99%, Missing); parathyroid gland: 60.6299% (minimum 97%, Missing); pituitary gland: 35.6481% (minimum 99%, Missing); rectum: 58.7786% (minimum 97%, Missing); retina: 33.4783% (minimum 99%, Missing); salivary gland: 64.7059% (minimum 97%, Missing); skeletal muscle: 53.8462% (minimum 99%, Missing); skin: 58.3333% (minimum 95%, Missing); small intestine: 61.1111% (minimum 99%, Missing); smooth muscle: 53.8462% (minimum 99%, Missing); spinal cord: 57.0370% (minimum 99%, Missing); spleen: 57.8947% (minimum 95%, Missing); stomach: 65.8120% (minimum 97%, Missing); thymus: 62.6016% (minimum 95%, Missing); thyroid gland: 51.6779% (minimum 95%, Missing); tongue: 52.7397% (minimum 97%, Missing); urinary bladder: 65.2542% (minimum 97%, Missing)",-0.433221,-0.442603,-0.656667,0,80,unavailable,15.4,6.9,7.2,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); tongue: 6.9 nTPM (protected, limit 2); skeletal muscle: 6.6 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); hypothalamus: 6 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); amygdala: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); rectum: 5.4 nTPM (protected, limit 2); adipose tissue: 5.3 nTPM (manageable, limit 5); lung: 5.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 2); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); adrenal gland: 4.1 nTPM (vital, limit 1); urinary bladder: 4.1 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); stomach: 4 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167377,ZNF23,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.2308% (minimum 65%, Missing); adrenal gland: 65.2542% (minimum 75%, Missing); amygdala: 58.3333% (minimum 75%, Missing); basal ganglia: 57.8947% (minimum 75%, Missing); bone marrow: 64.1667% (minimum 75%, Missing); cerebellum: 42.3077% (minimum 75%, Missing); cerebral cortex: 54.6099% (minimum 75%, Missing); choroid plexus: 33.3333% (minimum 75%, Missing); colon: 58.7786% (minimum 70%, Missing); duodenum: 72.6415% (minimum 75%, Missing); esophagus: 65.8120% (minimum 70%, Missing); heart muscle: 60.6299% (minimum 75%, Missing); hippocampal formation: 55.3957% (minimum 75%, Missing); hypothalamus: 56.2044% (minimum 75%, Missing); kidney: 58.3333% (minimum 75%, Missing); liver: 59.6899% (minimum 75%, Missing); lung: 59.6899% (minimum 75%, Missing); lymph node: 56.2044% (minimum 70%, Missing); midbrain: 61.1111% (minimum 75%, Missing); pancreas: 63.6364% (minimum 75%, Missing); parathyroid gland: 60.6299% (minimum 70%, Missing); pituitary gland: 35.6481% (minimum 75%, Missing); rectum: 58.7786% (minimum 70%, Missing); retina: 33.4783% (minimum 75%, Missing); salivary gland: 64.7059% (minimum 70%, Missing); skeletal muscle: 53.8462% (minimum 75%, Missing); skin: 58.3333% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); smooth muscle: 53.8462% (minimum 75%, Missing); spinal cord: 57.0370% (minimum 75%, Missing); spleen: 57.8947% (minimum 65%, Missing); stomach: 65.8120% (minimum 70%, Missing); thymus: 62.6016% (minimum 65%, Missing); thyroid gland: 51.6779% (minimum 65%, Missing); tongue: 52.7397% (minimum 70%, Missing); urinary bladder: 65.2542% (minimum 70%, Missing)",-0.133221,-0.172603,-0.416667,0,80,unavailable,15.4,6.9,7.2,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); tongue: 6.9 nTPM (protected, limit 2); skeletal muscle: 6.6 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); hypothalamus: 6 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); amygdala: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); rectum: 5.4 nTPM (protected, limit 2); adipose tissue: 5.3 nTPM (manageable, limit 5); lung: 5.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 2); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); adrenal gland: 4.1 nTPM (vital, limit 1); urinary bladder: 4.1 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); stomach: 4 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167377,ZNF23,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.2308% (minimum 65%, Missing); adrenal gland: 65.2542% (minimum 75%, Missing); amygdala: 58.3333% (minimum 75%, Missing); basal ganglia: 57.8947% (minimum 75%, Missing); bone marrow: 64.1667% (minimum 75%, Missing); cerebellum: 42.3077% (minimum 75%, Missing); cerebral cortex: 54.6099% (minimum 75%, Missing); choroid plexus: 33.3333% (minimum 75%, Missing); colon: 58.7786% (minimum 70%, Missing); duodenum: 72.6415% (minimum 75%, Missing); esophagus: 65.8120% (minimum 70%, Missing); heart muscle: 60.6299% (minimum 75%, Missing); hippocampal formation: 55.3957% (minimum 75%, Missing); hypothalamus: 56.2044% (minimum 75%, Missing); kidney: 58.3333% (minimum 75%, Missing); liver: 59.6899% (minimum 75%, Missing); lung: 59.6899% (minimum 75%, Missing); lymph node: 56.2044% (minimum 70%, Missing); midbrain: 61.1111% (minimum 75%, Missing); pancreas: 63.6364% (minimum 75%, Missing); parathyroid gland: 60.6299% (minimum 70%, Missing); pituitary gland: 35.6481% (minimum 75%, Missing); rectum: 58.7786% (minimum 70%, Missing); retina: 33.4783% (minimum 75%, Missing); salivary gland: 64.7059% (minimum 70%, Missing); skeletal muscle: 53.8462% (minimum 75%, Missing); skin: 58.3333% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); smooth muscle: 53.8462% (minimum 75%, Missing); spinal cord: 57.0370% (minimum 75%, Missing); spleen: 57.8947% (minimum 65%, Missing); stomach: 65.8120% (minimum 70%, Missing); thymus: 62.6016% (minimum 65%, Missing); thyroid gland: 51.6779% (minimum 65%, Missing); tongue: 52.7397% (minimum 70%, Missing); urinary bladder: 65.2542% (minimum 70%, Missing)",-0.133221,-0.172603,-0.416667,0,80,unavailable,15.4,6.9,7.2,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); tongue: 6.9 nTPM (protected, limit 3); skeletal muscle: 6.6 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); hypothalamus: 6 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); amygdala: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); rectum: 5.4 nTPM (protected, limit 3); adipose tissue: 5.3 nTPM (manageable, limit 5); lung: 5.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 3); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); adrenal gland: 4.1 nTPM (vital, limit 1); urinary bladder: 4.1 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); stomach: 4 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167377,ZNF23,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.2308% (minimum 65%, Missing); adrenal gland: 65.2542% (minimum 75%, Missing); amygdala: 58.3333% (minimum 75%, Missing); basal ganglia: 57.8947% (minimum 75%, Missing); bone marrow: 64.1667% (minimum 75%, Missing); cerebellum: 42.3077% (minimum 75%, Missing); cerebral cortex: 54.6099% (minimum 75%, Missing); choroid plexus: 33.3333% (minimum 75%, Missing); colon: 58.7786% (minimum 70%, Missing); duodenum: 72.6415% (minimum 75%, Missing); esophagus: 65.8120% (minimum 70%, Missing); heart muscle: 60.6299% (minimum 75%, Missing); hippocampal formation: 55.3957% (minimum 75%, Missing); hypothalamus: 56.2044% (minimum 75%, Missing); kidney: 58.3333% (minimum 75%, Missing); liver: 59.6899% (minimum 75%, Missing); lung: 59.6899% (minimum 75%, Missing); lymph node: 56.2044% (minimum 70%, Missing); midbrain: 61.1111% (minimum 75%, Missing); pancreas: 63.6364% (minimum 75%, Missing); parathyroid gland: 60.6299% (minimum 70%, Missing); pituitary gland: 35.6481% (minimum 75%, Missing); rectum: 58.7786% (minimum 70%, Missing); retina: 33.4783% (minimum 75%, Missing); salivary gland: 64.7059% (minimum 70%, Missing); skeletal muscle: 53.8462% (minimum 75%, Missing); skin: 58.3333% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); smooth muscle: 53.8462% (minimum 75%, Missing); spinal cord: 57.0370% (minimum 75%, Missing); spleen: 57.8947% (minimum 65%, Missing); stomach: 65.8120% (minimum 70%, Missing); thymus: 62.6016% (minimum 65%, Missing); thyroid gland: 51.6779% (minimum 65%, Missing); tongue: 52.7397% (minimum 70%, Missing); urinary bladder: 65.2542% (minimum 70%, Missing)",-0.133221,-0.172603,-0.416667,0,80,unavailable,15.4,6.9,7.2,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); tongue: 6.9 nTPM (protected, limit 3); skeletal muscle: 6.6 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); hypothalamus: 6 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); amygdala: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); rectum: 5.4 nTPM (protected, limit 3); adipose tissue: 5.3 nTPM (manageable, limit 5); lung: 5.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 3); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); adrenal gland: 4.1 nTPM (vital, limit 1); urinary bladder: 4.1 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); stomach: 4 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167377,ZNF23,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.2308% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 65.2542% (minimum 75%, Baseline (adaptation disabled)); amygdala: 58.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 57.8947% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 64.1667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 42.3077% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 54.6099% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 33.3333% (minimum 75%, Baseline (adaptation disabled)); colon: 58.7786% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.6415% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.8120% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.6299% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.3957% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 56.2044% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.3333% (minimum 75%, Baseline (adaptation disabled)); liver: 59.6899% (minimum 75%, Baseline (adaptation disabled)); lung: 59.6899% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.2044% (minimum 70%, Baseline (adaptation disabled)); midbrain: 61.1111% (minimum 75%, Baseline (adaptation disabled)); pancreas: 63.6364% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.6299% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 35.6481% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.7786% (minimum 70%, Baseline (adaptation disabled)); retina: 33.4783% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.7059% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 53.8462% (minimum 75%, Baseline (adaptation disabled)); skin: 58.3333% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.1111% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.8462% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.0370% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.8947% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.8120% (minimum 70%, Baseline (adaptation disabled)); thymus: 62.6016% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 51.6779% (minimum 65%, Baseline (adaptation disabled)); tongue: 52.7397% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.2542% (minimum 70%, Baseline (adaptation disabled))",-0.133221,-0.172603,-0.416667,0,80,unavailable,15.4,6.9,7.2,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); tongue: 6.9 nTPM (protected, limit 3); skeletal muscle: 6.6 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); hypothalamus: 6 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); amygdala: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); rectum: 5.4 nTPM (protected, limit 3); adipose tissue: 5.3 nTPM (manageable, limit 5); lung: 5.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 3); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); adrenal gland: 4.1 nTPM (vital, limit 1); urinary bladder: 4.1 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); stomach: 4 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167377,ZNF23,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4803% (minimum 95%, Missing); adrenal gland: 53.2847% (minimum 99%, Missing); amygdala: 55.7252% (minimum 99%, Missing); basal ganglia: 54.4776% (minimum 99%, Missing); bone marrow: 48.3444% (minimum 99%, Missing); cerebellum: 50.3448% (minimum 99%, Missing); cerebral cortex: 50.3448% (minimum 99%, Missing); choroid plexus: 77.6596% (minimum 99%, Missing); colon: 57.4803% (minimum 97%, Missing); duodenum: 62.9310% (minimum 99%, Missing); esophagus: 54.0741% (minimum 97%, Missing); heart muscle: 57.0312% (minimum 99%, Missing); hippocampal formation: 53.2847% (minimum 99%, Missing); hypothalamus: 57.4803% (minimum 99%, Missing); kidney: 62.9310% (minimum 99%, Missing); liver: 60.8333% (minimum 99%, Missing); lung: 62.9310% (minimum 99%, Missing); lymph node: 73.7374% (minimum 97%, Missing); midbrain: 59.8361% (minimum 99%, Missing); pancreas: 65.7658% (minimum 99%, Missing); parathyroid gland: 76.8421% (minimum 97%, Missing); pituitary gland: 60.3306% (minimum 99%, Missing); rectum: 84.8837% (minimum 97%, Missing); retina: 90.1235% (minimum 99%, Missing); salivary gland: 61.8644% (minimum 97%, Missing); skeletal muscle: 55.3030% (minimum 99%, Missing); skin: 50.6944% (minimum 95%, Missing); small intestine: 60.8333% (minimum 99%, Missing); smooth muscle: 68.8679% (minimum 99%, Missing); spinal cord: 59.3496% (minimum 99%, Missing); spleen: 55.7252% (minimum 95%, Missing); stomach: 61.3445% (minimum 97%, Missing); thymus: 71.5686% (minimum 95%, Missing); thyroid gland: 64.6018% (minimum 95%, Missing); tongue: 82.0225% (minimum 97%, Missing); urinary bladder: 54.8872% (minimum 97%, Missing)",-0.443056,-0.429259,-0.506556,0,2,partial,7.8,6.2,7.1,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167394,ZNF668,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4803% (minimum 65%, Missing); adrenal gland: 53.2847% (minimum 75%, Missing); amygdala: 55.7252% (minimum 75%, Missing); basal ganglia: 54.4776% (minimum 75%, Missing); bone marrow: 48.3444% (minimum 75%, Missing); cerebellum: 50.3448% (minimum 75%, Missing); cerebral cortex: 50.3448% (minimum 75%, Missing); colon: 57.4803% (minimum 70%, Missing); duodenum: 62.9310% (minimum 75%, Missing); esophagus: 54.0741% (minimum 70%, Missing); heart muscle: 57.0312% (minimum 75%, Missing); hippocampal formation: 53.2847% (minimum 75%, Missing); hypothalamus: 57.4803% (minimum 75%, Missing); kidney: 62.9310% (minimum 75%, Missing); liver: 60.8333% (minimum 75%, Missing); lung: 62.9310% (minimum 75%, Missing); midbrain: 59.8361% (minimum 75%, Missing); pancreas: 65.7658% (minimum 75%, Missing); pituitary gland: 60.3306% (minimum 75%, Missing); salivary gland: 61.8644% (minimum 70%, Missing); skeletal muscle: 55.3030% (minimum 75%, Missing); skin: 50.6944% (minimum 65%, Missing); small intestine: 60.8333% (minimum 75%, Missing); smooth muscle: 68.8679% (minimum 75%, Missing); spinal cord: 59.3496% (minimum 75%, Missing); spleen: 55.7252% (minimum 65%, Missing); stomach: 61.3445% (minimum 70%, Missing); thyroid gland: 64.6018% (minimum 65%, Missing); urinary bladder: 54.8872% (minimum 70%, Missing)",-0.143056,-0.159259,-0.266556,0,2,partial,7.8,6.2,7.1,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167394,ZNF668,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4803% (minimum 65%, Missing); adrenal gland: 53.2847% (minimum 75%, Missing); amygdala: 55.7252% (minimum 75%, Missing); basal ganglia: 54.4776% (minimum 75%, Missing); bone marrow: 48.3444% (minimum 75%, Missing); cerebellum: 50.3448% (minimum 75%, Missing); cerebral cortex: 50.3448% (minimum 75%, Missing); colon: 57.4803% (minimum 70%, Missing); duodenum: 62.9310% (minimum 75%, Missing); esophagus: 54.0741% (minimum 70%, Missing); heart muscle: 57.0312% (minimum 75%, Missing); hippocampal formation: 53.2847% (minimum 75%, Missing); hypothalamus: 57.4803% (minimum 75%, Missing); kidney: 62.9310% (minimum 75%, Missing); liver: 60.8333% (minimum 75%, Missing); lung: 62.9310% (minimum 75%, Missing); midbrain: 59.8361% (minimum 75%, Missing); pancreas: 65.7658% (minimum 75%, Missing); pituitary gland: 60.3306% (minimum 75%, Missing); salivary gland: 61.8644% (minimum 70%, Missing); skeletal muscle: 55.3030% (minimum 75%, Missing); skin: 50.6944% (minimum 65%, Missing); small intestine: 60.8333% (minimum 75%, Missing); smooth muscle: 68.8679% (minimum 75%, Missing); spinal cord: 59.3496% (minimum 75%, Missing); spleen: 55.7252% (minimum 65%, Missing); stomach: 61.3445% (minimum 70%, Missing); thyroid gland: 64.6018% (minimum 65%, Missing); urinary bladder: 54.8872% (minimum 70%, Missing)",-0.143056,-0.159259,-0.266556,0,2,partial,7.8,6.2,7.1,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 3); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); salivary gland: 4.5 nTPM (protected, limit 3); lung: 4.3 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167394,ZNF668,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4803% (minimum 65%, Missing); adrenal gland: 53.2847% (minimum 75%, Missing); amygdala: 55.7252% (minimum 75%, Missing); basal ganglia: 54.4776% (minimum 75%, Missing); bone marrow: 48.3444% (minimum 75%, Missing); cerebellum: 50.3448% (minimum 75%, Missing); cerebral cortex: 50.3448% (minimum 75%, Missing); colon: 57.4803% (minimum 70%, Missing); duodenum: 62.9310% (minimum 75%, Missing); esophagus: 54.0741% (minimum 70%, Missing); heart muscle: 57.0312% (minimum 75%, Missing); hippocampal formation: 53.2847% (minimum 75%, Missing); hypothalamus: 57.4803% (minimum 75%, Missing); kidney: 62.9310% (minimum 75%, Missing); liver: 60.8333% (minimum 75%, Missing); lung: 62.9310% (minimum 75%, Missing); midbrain: 59.8361% (minimum 75%, Missing); pancreas: 65.7658% (minimum 75%, Missing); pituitary gland: 60.3306% (minimum 75%, Missing); salivary gland: 61.8644% (minimum 70%, Missing); skeletal muscle: 55.3030% (minimum 75%, Missing); skin: 50.6944% (minimum 65%, Missing); small intestine: 60.8333% (minimum 75%, Missing); smooth muscle: 68.8679% (minimum 75%, Missing); spinal cord: 59.3496% (minimum 75%, Missing); spleen: 55.7252% (minimum 65%, Missing); stomach: 61.3445% (minimum 70%, Missing); thyroid gland: 64.6018% (minimum 65%, Missing); urinary bladder: 54.8872% (minimum 70%, Missing)",-0.143056,-0.159259,-0.266556,0,2,partial,7.8,6.2,7.1,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 3); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); salivary gland: 4.5 nTPM (protected, limit 3); lung: 4.3 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167394,ZNF668,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4803% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 53.2847% (minimum 75%, Baseline (adaptation disabled)); amygdala: 55.7252% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.4776% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 48.3444% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 50.3448% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.3448% (minimum 75%, Baseline (adaptation disabled)); colon: 57.4803% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.9310% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.0741% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 57.0312% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 53.2847% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 57.4803% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.9310% (minimum 75%, Baseline (adaptation disabled)); liver: 60.8333% (minimum 75%, Baseline (adaptation disabled)); lung: 62.9310% (minimum 75%, Baseline (adaptation disabled)); midbrain: 59.8361% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.7658% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 60.3306% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.8644% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.3030% (minimum 75%, Baseline (adaptation disabled)); skin: 50.6944% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.8333% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.8679% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.3496% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.7252% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.3445% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 64.6018% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 54.8872% (minimum 70%, Baseline (adaptation disabled))",-0.143056,-0.159259,-0.266556,0,2,partial,7.8,6.2,7.1,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 3); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); salivary gland: 4.5 nTPM (protected, limit 3); lung: 4.3 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167394,ZNF668,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.2368% (minimum 95%, Uncertain); adrenal gland: 86.2069% (minimum 99%, Missing); amygdala: 87.4126% (minimum 99%, Missing); basal ganglia: 86.8056% (minimum 99%, Missing); bone marrow: 73.3138% (minimum 99%, Uncertain); cerebellum: 79.3651% (minimum 99%, Uncertain); cerebral cortex: 84.7458% (minimum 99%, Missing); choroid plexus: 96.1538% (minimum 99%, Missing); colon: 83.6120% (minimum 97%, Missing); duodenum: 80.1282% (minimum 99%, Uncertain); esophagus: 83.3333% (minimum 97%, Uncertain); heart muscle: 84.4595% (minimum 99%, Uncertain); hippocampal formation: 86.2069% (minimum 99%, Missing); hypothalamus: 88.3392% (minimum 99%, Missing); kidney: 84.1751% (minimum 99%, Missing); liver: 85.6164% (minimum 99%, Missing); lung: 84.7458% (minimum 99%, Uncertain); lymph node: 78.1250% (minimum 97%, Uncertain); midbrain: 88.0282% (minimum 99%, Missing); pancreas: 82.2368% (minimum 99%, Uncertain); parathyroid gland: 85.3242% (minimum 97%, Uncertain); pituitary gland: 83.6120% (minimum 99%, Missing); rectum: 90.2527% (minimum 97%, Uncertain); retina: 93.9850% (minimum 99%, Missing); salivary gland: 80.6452% (minimum 97%, Uncertain); skeletal muscle: 76.6871% (minimum 99%, Uncertain); skin: 76.2195% (minimum 95%, Uncertain); small intestine: 79.8722% (minimum 99%, Uncertain); smooth muscle: 88.9680% (minimum 99%, Uncertain); spinal cord: 86.5052% (minimum 99%, Missing); spleen: 76.2195% (minimum 95%, Uncertain); stomach: 82.2368% (minimum 97%, Uncertain); thymus: 75.0751% (minimum 95%, Missing); thyroid gland: 83.3333% (minimum 95%, Uncertain); tongue: 87.7193% (minimum 97%, Missing); urinary bladder: 82.7815% (minimum 97%, Uncertain)",-0.199249,-0.18875,-0.256862,0,2,partial,9.1,7,8.3,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 2); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 2); adipose tissue: 5.4 nTPM (manageable, limit 5); stomach: 5.4 nTPM (protected, limit 2); pancreas: 5.4 nTPM (vital, limit 1); urinary bladder: 5.2 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); colon: 4.9 nTPM (protected, limit 2); pituitary gland: 4.9 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); liver: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167395,ZNF646,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 73.3138% (minimum 75%, Uncertain)",0.100751,0.08125,-0.0168622,0,2,partial,9.1,7,8.3,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 2); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 2); adipose tissue: 5.4 nTPM (manageable, limit 5); stomach: 5.4 nTPM (protected, limit 2); pancreas: 5.4 nTPM (vital, limit 1); urinary bladder: 5.2 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); colon: 4.9 nTPM (protected, limit 2); pituitary gland: 4.9 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); liver: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167395,ZNF646,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 73.3138% (minimum 75%, Uncertain)",0.100751,0.08125,-0.0168622,0,2,partial,9.1,7,8.3,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 3); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 3); pancreas: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); adipose tissue: 5.4 nTPM (manageable, limit 5); urinary bladder: 5.2 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); pituitary gland: 4.9 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); liver: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167395,ZNF646,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 73.3138% (minimum 75%, Uncertain)",0.100751,0.08125,-0.0168622,0,2,partial,9.1,7,8.3,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 3); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 3); pancreas: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); adipose tissue: 5.4 nTPM (manageable, limit 5); urinary bladder: 5.2 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); pituitary gland: 4.9 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); liver: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167395,ZNF646,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 73.3138% (minimum 75%, Baseline (adaptation disabled))",0.100751,0.08125,-0.0168622,0,2,partial,9.1,7,8.3,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 3); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 3); pancreas: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); adipose tissue: 5.4 nTPM (manageable, limit 5); urinary bladder: 5.2 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); pituitary gland: 4.9 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); liver: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167395,ZNF646,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6609% (minimum 90%, Approved); adrenal gland: 51.6698% (minimum 99%, Missing); amygdala: 72.0569% (minimum 99%, Missing); basal ganglia: 68.5117% (minimum 99%, Missing); bone marrow: 67.1894% (minimum 99%, Missing); cerebellum: 72.8105% (minimum 99%, Missing); cerebral cortex: 73.4344% (minimum 99%, Missing); choroid plexus: 42.3574% (minimum 99%, Missing); colon: 54.2885% (minimum 97%, Missing); duodenum: 72.1970% (minimum 99%, Missing); esophagus: 68.8504% (minimum 97%, Missing); heart muscle: 53.7645% (minimum 98%, Approved); hippocampal formation: 70.3727% (minimum 99%, Missing); hypothalamus: 70.1070% (minimum 99%, Missing); kidney: 48.2878% (minimum 99%, Missing); liver: 20.0685% (minimum 99%, Missing); lung: 59.7639% (minimum 99%, Missing); lymph node: 76.0929% (minimum 97%, Missing); midbrain: 67.7204% (minimum 99%, Missing); pancreas: 40.6421% (minimum 99%, Missing); parathyroid gland: 69.2356% (minimum 97%, Missing); pituitary gland: 49.7321% (minimum 99%, Missing); rectum: 73.7260% (minimum 95%, Approved); retina: 83.3832% (minimum 99%, Missing); salivary gland: 55.3953% (minimum 97%, Missing); skeletal muscle: 77.0401% (minimum 98%, Approved); skin: 58.6316% (minimum 95%, Missing); small intestine: 58.2331% (minimum 99%, Missing); smooth muscle: 57.7202% (minimum 98%, Approved); spinal cord: 65.5680% (minimum 99%, Missing); spleen: 64.7298% (minimum 95%, Missing); stomach: 56.6057% (minimum 97%, Missing); thymus: 76.6162% (minimum 95%, Missing); thyroid gland: 60.0863% (minimum 95%, Missing); tongue: 78.1754% (minimum 97%, Missing); urinary bladder: 53.3781% (minimum 97%, Missing)",-0.363684,-0.436219,-0.789315,0,4,partial,443.7,97.3,96.2,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 2); adipose tissue: 96.2 nTPM (manageable, limit 10); heart muscle: 95.8 nTPM (vital, limit 2); colon: 93.8 nTPM (protected, limit 2); salivary gland: 89.7 nTPM (protected, limit 2); stomach: 85.4 nTPM (protected, limit 2); smooth muscle: 81.6 nTPM (vital, limit 2); small intestine: 79.9 nTPM (vital, limit 1); skin: 78.6 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (manageable, limit 5); spleen: 60.7 nTPM (manageable, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 2); parathyroid gland: 49.5 nTPM (protected, limit 2); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 4); lymph node: 35 nTPM (protected, limit 2); thymus: 34 nTPM (manageable, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 2); tongue: 31.1 nTPM (protected, limit 2); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167397,VKORC1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6609% (minimum 60%, Approved); adrenal gland: 51.6698% (minimum 75%, Missing); amygdala: 72.0569% (minimum 75%, Missing); basal ganglia: 68.5117% (minimum 75%, Missing); bone marrow: 67.1894% (minimum 75%, Missing); cerebellum: 72.8105% (minimum 75%, Missing); cerebral cortex: 73.4344% (minimum 75%, Missing); choroid plexus: 42.3574% (minimum 75%, Missing); colon: 54.2885% (minimum 70%, Missing); duodenum: 72.1970% (minimum 75%, Missing); esophagus: 68.8504% (minimum 70%, Missing); heart muscle: 53.7645% (minimum 70%, Approved); hippocampal formation: 70.3727% (minimum 75%, Missing); hypothalamus: 70.1070% (minimum 75%, Missing); kidney: 48.2878% (minimum 75%, Missing); liver: 20.0685% (minimum 75%, Missing); lung: 59.7639% (minimum 75%, Missing); midbrain: 67.7204% (minimum 75%, Missing); pancreas: 40.6421% (minimum 75%, Missing); parathyroid gland: 69.2356% (minimum 70%, Missing); pituitary gland: 49.7321% (minimum 75%, Missing); salivary gland: 55.3953% (minimum 70%, Missing); skin: 58.6316% (minimum 65%, Missing); small intestine: 58.2331% (minimum 75%, Missing); smooth muscle: 57.7202% (minimum 70%, Approved); spinal cord: 65.5680% (minimum 75%, Missing); spleen: 64.7298% (minimum 65%, Missing); stomach: 56.6057% (minimum 70%, Missing); thyroid gland: 60.0863% (minimum 65%, Missing); urinary bladder: 53.3781% (minimum 70%, Missing)",-0.0636842,-0.166219,-0.549315,0,4,partial,443.7,97.3,96.2,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 2); adipose tissue: 96.2 nTPM (manageable, limit 10); heart muscle: 95.8 nTPM (vital, limit 2); colon: 93.8 nTPM (protected, limit 2); salivary gland: 89.7 nTPM (protected, limit 2); stomach: 85.4 nTPM (protected, limit 2); smooth muscle: 81.6 nTPM (vital, limit 2); small intestine: 79.9 nTPM (vital, limit 1); skin: 78.6 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (manageable, limit 5); spleen: 60.7 nTPM (manageable, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 2); parathyroid gland: 49.5 nTPM (protected, limit 2); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 4); lymph node: 35 nTPM (protected, limit 2); thymus: 34 nTPM (manageable, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 2); tongue: 31.1 nTPM (protected, limit 2); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167397,VKORC1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6609% (minimum 60%, Approved); adrenal gland: 51.6698% (minimum 75%, Missing); amygdala: 72.0569% (minimum 75%, Missing); basal ganglia: 68.5117% (minimum 75%, Missing); bone marrow: 67.1894% (minimum 75%, Missing); cerebellum: 72.8105% (minimum 75%, Missing); cerebral cortex: 73.4344% (minimum 75%, Missing); choroid plexus: 42.3574% (minimum 75%, Missing); colon: 54.2885% (minimum 70%, Missing); duodenum: 72.1970% (minimum 75%, Missing); esophagus: 68.8504% (minimum 70%, Missing); heart muscle: 53.7645% (minimum 70%, Approved); hippocampal formation: 70.3727% (minimum 75%, Missing); hypothalamus: 70.1070% (minimum 75%, Missing); kidney: 48.2878% (minimum 75%, Missing); liver: 20.0685% (minimum 75%, Missing); lung: 59.7639% (minimum 75%, Missing); midbrain: 67.7204% (minimum 75%, Missing); pancreas: 40.6421% (minimum 75%, Missing); parathyroid gland: 69.2356% (minimum 70%, Missing); pituitary gland: 49.7321% (minimum 75%, Missing); salivary gland: 55.3953% (minimum 70%, Missing); skin: 58.6316% (minimum 65%, Missing); small intestine: 58.2331% (minimum 75%, Missing); smooth muscle: 57.7202% (minimum 70%, Approved); spinal cord: 65.5680% (minimum 75%, Missing); spleen: 64.7298% (minimum 65%, Missing); stomach: 56.6057% (minimum 70%, Missing); thyroid gland: 60.0863% (minimum 65%, Missing); urinary bladder: 53.3781% (minimum 70%, Missing)",-0.0636842,-0.166219,-0.549315,0,4,partial,443.7,97.3,96.2,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 3); adipose tissue: 96.2 nTPM (manageable, limit 10); heart muscle: 95.8 nTPM (vital, limit 2); colon: 93.8 nTPM (protected, limit 3); salivary gland: 89.7 nTPM (protected, limit 3); stomach: 85.4 nTPM (protected, limit 3); smooth muscle: 81.6 nTPM (vital, limit 2); small intestine: 79.9 nTPM (vital, limit 1); skin: 78.6 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (manageable, limit 5); spleen: 60.7 nTPM (manageable, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 3); parathyroid gland: 49.5 nTPM (protected, limit 3); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 4); lymph node: 35 nTPM (protected, limit 3); thymus: 34 nTPM (manageable, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 2); tongue: 31.1 nTPM (protected, limit 3); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167397,VKORC1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6609% (minimum 60%, Approved); adrenal gland: 51.6698% (minimum 75%, Missing); amygdala: 72.0569% (minimum 75%, Missing); basal ganglia: 68.5117% (minimum 75%, Missing); bone marrow: 67.1894% (minimum 75%, Missing); cerebellum: 72.8105% (minimum 75%, Missing); cerebral cortex: 73.4344% (minimum 75%, Missing); choroid plexus: 42.3574% (minimum 75%, Missing); colon: 54.2885% (minimum 70%, Missing); duodenum: 72.1970% (minimum 75%, Missing); esophagus: 68.8504% (minimum 70%, Missing); heart muscle: 53.7645% (minimum 70%, Approved); hippocampal formation: 70.3727% (minimum 75%, Missing); hypothalamus: 70.1070% (minimum 75%, Missing); kidney: 48.2878% (minimum 75%, Missing); liver: 20.0685% (minimum 75%, Missing); lung: 59.7639% (minimum 75%, Missing); midbrain: 67.7204% (minimum 75%, Missing); pancreas: 40.6421% (minimum 75%, Missing); parathyroid gland: 69.2356% (minimum 70%, Missing); pituitary gland: 49.7321% (minimum 75%, Missing); salivary gland: 55.3953% (minimum 70%, Missing); skin: 58.6316% (minimum 65%, Missing); small intestine: 58.2331% (minimum 75%, Missing); smooth muscle: 57.7202% (minimum 70%, Approved); spinal cord: 65.5680% (minimum 75%, Missing); spleen: 64.7298% (minimum 65%, Missing); stomach: 56.6057% (minimum 70%, Missing); thyroid gland: 60.0863% (minimum 65%, Missing); urinary bladder: 53.3781% (minimum 70%, Missing)",-0.0636842,-0.166219,-0.549315,0,4,partial,443.7,97.3,96.2,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 3); adipose tissue: 96.2 nTPM (manageable, limit 10); heart muscle: 95.8 nTPM (vital, limit 2); colon: 93.8 nTPM (protected, limit 3); salivary gland: 89.7 nTPM (protected, limit 3); stomach: 85.4 nTPM (protected, limit 3); smooth muscle: 81.6 nTPM (vital, limit 2); small intestine: 79.9 nTPM (vital, limit 1); skin: 78.6 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (manageable, limit 5); spleen: 60.7 nTPM (manageable, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 3); parathyroid gland: 49.5 nTPM (protected, limit 3); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 4); lymph node: 35 nTPM (protected, limit 3); thymus: 34 nTPM (manageable, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 2); tongue: 31.1 nTPM (protected, limit 3); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167397,VKORC1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6609% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 51.6698% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.0569% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 68.5117% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 67.1894% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.8105% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.4344% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 42.3574% (minimum 75%, Baseline (adaptation disabled)); colon: 54.2885% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.1970% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.8504% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 53.7645% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.3727% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 70.1070% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.2878% (minimum 75%, Baseline (adaptation disabled)); liver: 20.0685% (minimum 75%, Baseline (adaptation disabled)); lung: 59.7639% (minimum 75%, Baseline (adaptation disabled)); midbrain: 67.7204% (minimum 75%, Baseline (adaptation disabled)); pancreas: 40.6421% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.2356% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 49.7321% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.3953% (minimum 70%, Baseline (adaptation disabled)); skin: 58.6316% (minimum 65%, Baseline (adaptation disabled)); small intestine: 58.2331% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.7202% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.5680% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.7298% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.6057% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 60.0863% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 53.3781% (minimum 70%, Baseline (adaptation disabled))",-0.113391,-0.166219,-0.549315,0,4,partial,443.7,97.3,96.2,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 3); adipose tissue: 96.2 nTPM (manageable, limit 5); heart muscle: 95.8 nTPM (vital, limit 1); colon: 93.8 nTPM (protected, limit 3); salivary gland: 89.7 nTPM (protected, limit 3); stomach: 85.4 nTPM (protected, limit 3); smooth muscle: 81.6 nTPM (vital, limit 1); small intestine: 79.9 nTPM (vital, limit 1); skin: 78.6 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (manageable, limit 5); spleen: 60.7 nTPM (manageable, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 3); parathyroid gland: 49.5 nTPM (protected, limit 3); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 3); lymph node: 35 nTPM (protected, limit 3); thymus: 34 nTPM (manageable, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 3); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167397,VKORC1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.3446% (minimum 99%, Missing); basal ganglia: 93.8983% (minimum 99%, Missing); cerebral cortex: 92.4875% (minimum 95%, Enhanced); choroid plexus: 89.2828% (minimum 99%, Missing); colon: 95.6822% (minimum 97%, Missing); duodenum: 95.8478% (minimum 99%, Missing); hippocampal formation: 93.0311% (minimum 99%, Missing); hypothalamus: 92.2565% (minimum 99%, Missing); kidney: 90.5969% (minimum 99%, Missing); liver: 94.7819% (minimum 95%, Enhanced); midbrain: 95.1073% (minimum 99%, Missing); pituitary gland: 92.1031% (minimum 99%, Missing); retina: 94.4587% (minimum 99%, Missing); small intestine: 92.5647% (minimum 99%, Missing); spinal cord: 95.5997% (minimum 99%, Missing); stomach: 95.7649% (minimum 97%, Missing)",0.0202277,-0.0131779,-0.0971716,0,13,partial,13.3,5.1,8.1,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 6); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 6); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); duodenum: 4.8 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167523,SPATA33,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.320228,0.256822,0.142828,0,13,partial,13.3,5.1,8.1,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 6); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 6); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); duodenum: 4.8 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167523,SPATA33,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.320228,0.256822,0.142828,0,13,partial,13.3,5.1,8.1,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 6); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 6); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); duodenum: 4.8 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167523,SPATA33,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.320228,0.256822,0.142828,0,13,partial,13.3,5.1,8.1,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 6); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 6); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); duodenum: 4.8 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167523,SPATA33,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.281876,0.255997,0.142828,0,13,partial,13.3,5.1,8.1,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); esophagus: 5.1 nTPM (protected, limit 3); spinal cord: 5.1 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); duodenum: 4.8 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); salivary gland: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167523,SPATA33,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7337% (minimum 99%, Missing); basal ganglia: 97.1284% (minimum 99%, Missing); cerebellum: 95.9933% (minimum 98%, Approved); cerebral cortex: 97.4026% (minimum 98%, Approved); choroid plexus: 97.2927% (minimum 99%, Missing); hippocampal formation: 97.7337% (minimum 99%, Missing); hypothalamus: 97.2379% (minimum 99%, Missing); kidney: 95.5679% (minimum 98%, Approved); midbrain: 97.5679% (minimum 99%, Missing); pituitary gland: 98.3466% (minimum 99%, Missing); small intestine: 97.8446% (minimum 98%, Approved); spinal cord: 97.7891% (minimum 99%, Missing)",0.0419494,0.0271098,-0.0243213,0,4,partial,8,2.2,9.6,"kidney: 8 nTPM (vital, limit 2); cerebellum: 7.2 nTPM (vital, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); midbrain: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 2); retina: 1.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167525,PROCA1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341949,0.29711,0.221284,0,4,partial,8,2.2,9.6,"kidney: 8 nTPM (vital, limit 2); cerebellum: 7.2 nTPM (vital, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); midbrain: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 2); retina: 1.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167525,PROCA1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341949,0.29711,0.221284,0,4,partial,8,2.2,9.6,"kidney: 8 nTPM (vital, limit 2); cerebellum: 7.2 nTPM (vital, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); midbrain: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 2); retina: 1.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167525,PROCA1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341949,0.29711,0.221284,0,4,partial,8,2.2,9.6,"kidney: 8 nTPM (vital, limit 2); cerebellum: 7.2 nTPM (vital, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); midbrain: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 2); retina: 1.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167525,PROCA1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297282,0.287407,0.205679,0,4,partial,8,2.2,9.6,"spleen: 9.6 nTPM (manageable, limit 5); kidney: 8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167525,PROCA1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167531,LALBA,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167531,LALBA,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167531,LALBA,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167531,LALBA,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.299953,0.25,0,4,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167531,LALBA,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 81.2500% (minimum 95%, Enhanced); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 71.3415% (minimum 99%, Missing); bone marrow: 97.5000% (minimum 99%, Missing); cerebellum: 80.6897% (minimum 99%, Missing); cerebral cortex: 75.9740% (minimum 99%, Missing); choroid plexus: 76.4706% (minimum 99%, Missing); colon: 87.9699% (minimum 97%, Missing); duodenum: 94.3548% (minimum 99%, Missing); esophagus: 91.4062% (minimum 97%, Missing); heart muscle: 82.3944% (minimum 99%, Missing); hippocampal formation: 74.0506% (minimum 99%, Missing); hypothalamus: 73.1250% (minimum 99%, Missing); kidney: 77.4834% (minimum 99%, Missing); lung: 86.6667% (minimum 99%, Missing); lymph node: 88.6364% (minimum 97%, Missing); midbrain: 73.1250% (minimum 99%, Missing); pancreas: 89.3130% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 80%, Enhanced); pituitary gland: 82.9787% (minimum 99%, Missing); rectum: 89.3130% (minimum 97%, Missing); retina: 66.1017% (minimum 99%, Missing); salivary gland: 91.4062% (minimum 97%, Missing); skeletal muscle: 91.4062% (minimum 99%, Missing); skin: 94.3548% (minimum 95%, Missing); small intestine: 92.8571% (minimum 99%, Missing); smooth muscle: 82.9787% (minimum 99%, Missing); spinal cord: 70.4819% (minimum 99%, Missing); stomach: 88.6364% (minimum 97%, Missing); thymus: 79.5918% (minimum 95%, Missing); thyroid gland: 72.2222% (minimum 95%, Missing); tongue: 88.6364% (minimum 97%, Missing); urinary bladder: 87.3134% (minimum 97%, Missing)",-0.227778,-0.0968657,-0.328983,0,2,partial,6,3.9,4.5,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167554,ZNF610,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 71.3415% (minimum 75%, Missing); hippocampal formation: 74.0506% (minimum 75%, Missing); hypothalamus: 73.1250% (minimum 75%, Missing); midbrain: 73.1250% (minimum 75%, Missing); retina: 66.1017% (minimum 75%, Missing); spinal cord: 70.4819% (minimum 75%, Missing)",0.0722222,0.173134,-0.0889831,0,2,partial,6,3.9,4.5,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167554,ZNF610,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 71.3415% (minimum 75%, Missing); hippocampal formation: 74.0506% (minimum 75%, Missing); hypothalamus: 73.1250% (minimum 75%, Missing); midbrain: 73.1250% (minimum 75%, Missing); retina: 66.1017% (minimum 75%, Missing); spinal cord: 70.4819% (minimum 75%, Missing)",0.0722222,0.173134,-0.0889831,0,2,partial,6,3.9,4.5,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167554,ZNF610,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 71.3415% (minimum 75%, Missing); hippocampal formation: 74.0506% (minimum 75%, Missing); hypothalamus: 73.1250% (minimum 75%, Missing); midbrain: 73.1250% (minimum 75%, Missing); retina: 66.1017% (minimum 75%, Missing); spinal cord: 70.4819% (minimum 75%, Missing)",0.0722222,0.173134,-0.0889831,0,2,partial,6,3.9,4.5,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167554,ZNF610,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 71.3415% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.0506% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.1250% (minimum 75%, Baseline (adaptation disabled)); midbrain: 73.1250% (minimum 75%, Baseline (adaptation disabled)); retina: 66.1017% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.4819% (minimum 75%, Baseline (adaptation disabled))",0.0722222,0.05,-0.0889831,0,2,partial,6,3.9,4.5,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167554,ZNF610,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.0455% (minimum 95%, Missing); adrenal gland: 70.2381% (minimum 99%, Missing); amygdala: 81.9444% (minimum 99%, Missing); basal ganglia: 80.8219% (minimum 99%, Missing); bone marrow: 52.6786% (minimum 99%, Missing); cerebellum: 75.6410% (minimum 99%, Missing); cerebral cortex: 79.7297% (minimum 99%, Missing); choroid plexus: 76.6234% (minimum 99%, Missing); colon: 60.8247% (minimum 97%, Missing); duodenum: 64.8352% (minimum 99%, Missing); esophagus: 68.6047% (minimum 97%, Missing); heart muscle: 68.6047% (minimum 99%, Missing); hippocampal formation: 81.9444% (minimum 99%, Missing); hypothalamus: 81.9444% (minimum 99%, Missing); kidney: 62.7660% (minimum 99%, Missing); liver: 83.0986% (minimum 99%, Missing); lung: 61.4583% (minimum 99%, Missing); lymph node: 51.3043% (minimum 97%, Missing); midbrain: 80.8219% (minimum 99%, Missing); pancreas: 67.8161% (minimum 99%, Missing); parathyroid gland: 61.4583% (minimum 97%, Missing); pituitary gland: 72.8395% (minimum 99%, Missing); rectum: 55.6604% (minimum 97%, Missing); retina: 64.1304% (minimum 99%, Missing); salivary gland: 65.5556% (minimum 97%, Missing); skeletal muscle: 73.7500% (minimum 99%, Missing); skin: 59.0000% (minimum 95%, Missing); small intestine: 57.2816% (minimum 99%, Missing); smooth muscle: 64.8352% (minimum 99%, Missing); spinal cord: 77.6316% (minimum 99%, Missing); spleen: 55.6604% (minimum 95%, Missing); stomach: 57.2816% (minimum 97%, Missing); thymus: 45.0382% (minimum 95%, Missing); thyroid gland: 50.8621% (minimum 95%, Missing); tongue: 67.0455% (minimum 97%, Missing); urinary bladder: 65.5556% (minimum 97%, Missing)",-0.499618,-0.456957,-0.463214,0,80,unavailable,5.3,5.6,7.2,"thymus: 7.2 nTPM (manageable, limit 5); thyroid gland: 5.7 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); bone marrow: 5.3 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); lung: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167562,ZNF701,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.2381% (minimum 75%, Missing); bone marrow: 52.6786% (minimum 75%, Missing); colon: 60.8247% (minimum 70%, Missing); duodenum: 64.8352% (minimum 75%, Missing); esophagus: 68.6047% (minimum 70%, Missing); heart muscle: 68.6047% (minimum 75%, Missing); kidney: 62.7660% (minimum 75%, Missing); lung: 61.4583% (minimum 75%, Missing); lymph node: 51.3043% (minimum 70%, Missing); pancreas: 67.8161% (minimum 75%, Missing); parathyroid gland: 61.4583% (minimum 70%, Missing); pituitary gland: 72.8395% (minimum 75%, Missing); rectum: 55.6604% (minimum 70%, Missing); retina: 64.1304% (minimum 75%, Missing); salivary gland: 65.5556% (minimum 70%, Missing); skeletal muscle: 73.7500% (minimum 75%, Missing); skin: 59.0000% (minimum 65%, Missing); small intestine: 57.2816% (minimum 75%, Missing); smooth muscle: 64.8352% (minimum 75%, Missing); spleen: 55.6604% (minimum 65%, Missing); stomach: 57.2816% (minimum 70%, Missing); thymus: 45.0382% (minimum 65%, Missing); thyroid gland: 50.8621% (minimum 65%, Missing); tongue: 67.0455% (minimum 70%, Missing); urinary bladder: 65.5556% (minimum 70%, Missing)",-0.199618,-0.186957,-0.223214,0,80,unavailable,5.3,5.6,7.2,"thymus: 7.2 nTPM (manageable, limit 5); thyroid gland: 5.7 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); bone marrow: 5.3 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); lung: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167562,ZNF701,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.2381% (minimum 75%, Missing); bone marrow: 52.6786% (minimum 75%, Missing); colon: 60.8247% (minimum 70%, Missing); duodenum: 64.8352% (minimum 75%, Missing); esophagus: 68.6047% (minimum 70%, Missing); heart muscle: 68.6047% (minimum 75%, Missing); kidney: 62.7660% (minimum 75%, Missing); lung: 61.4583% (minimum 75%, Missing); lymph node: 51.3043% (minimum 70%, Missing); pancreas: 67.8161% (minimum 75%, Missing); parathyroid gland: 61.4583% (minimum 70%, Missing); pituitary gland: 72.8395% (minimum 75%, Missing); rectum: 55.6604% (minimum 70%, Missing); retina: 64.1304% (minimum 75%, Missing); salivary gland: 65.5556% (minimum 70%, Missing); skeletal muscle: 73.7500% (minimum 75%, Missing); skin: 59.0000% (minimum 65%, Missing); small intestine: 57.2816% (minimum 75%, Missing); smooth muscle: 64.8352% (minimum 75%, Missing); spleen: 55.6604% (minimum 65%, Missing); stomach: 57.2816% (minimum 70%, Missing); thymus: 45.0382% (minimum 65%, Missing); thyroid gland: 50.8621% (minimum 65%, Missing); tongue: 67.0455% (minimum 70%, Missing); urinary bladder: 65.5556% (minimum 70%, Missing)",-0.199618,-0.186957,-0.223214,0,80,unavailable,5.3,5.6,7.2,"thymus: 7.2 nTPM (manageable, limit 5); thyroid gland: 5.7 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3); bone marrow: 5.3 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.7 nTPM (protected, limit 3); lung: 3.7 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); urinary bladder: 3.1 nTPM (protected, limit 3); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167562,ZNF701,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.2381% (minimum 75%, Missing); bone marrow: 52.6786% (minimum 75%, Missing); colon: 60.8247% (minimum 70%, Missing); duodenum: 64.8352% (minimum 75%, Missing); esophagus: 68.6047% (minimum 70%, Missing); heart muscle: 68.6047% (minimum 75%, Missing); kidney: 62.7660% (minimum 75%, Missing); lung: 61.4583% (minimum 75%, Missing); lymph node: 51.3043% (minimum 70%, Missing); pancreas: 67.8161% (minimum 75%, Missing); parathyroid gland: 61.4583% (minimum 70%, Missing); pituitary gland: 72.8395% (minimum 75%, Missing); rectum: 55.6604% (minimum 70%, Missing); retina: 64.1304% (minimum 75%, Missing); salivary gland: 65.5556% (minimum 70%, Missing); skeletal muscle: 73.7500% (minimum 75%, Missing); skin: 59.0000% (minimum 65%, Missing); small intestine: 57.2816% (minimum 75%, Missing); smooth muscle: 64.8352% (minimum 75%, Missing); spleen: 55.6604% (minimum 65%, Missing); stomach: 57.2816% (minimum 70%, Missing); thymus: 45.0382% (minimum 65%, Missing); thyroid gland: 50.8621% (minimum 65%, Missing); tongue: 67.0455% (minimum 70%, Missing); urinary bladder: 65.5556% (minimum 70%, Missing)",-0.199618,-0.186957,-0.223214,0,80,unavailable,5.3,5.6,7.2,"thymus: 7.2 nTPM (manageable, limit 5); thyroid gland: 5.7 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3); bone marrow: 5.3 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.7 nTPM (protected, limit 3); lung: 3.7 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); urinary bladder: 3.1 nTPM (protected, limit 3); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167562,ZNF701,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.2381% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 52.6786% (minimum 75%, Baseline (adaptation disabled)); colon: 60.8247% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.8352% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.6047% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.6047% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.7660% (minimum 75%, Baseline (adaptation disabled)); lung: 61.4583% (minimum 75%, Baseline (adaptation disabled)); lymph node: 51.3043% (minimum 70%, Baseline (adaptation disabled)); pancreas: 67.8161% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.4583% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.8395% (minimum 75%, Baseline (adaptation disabled)); rectum: 55.6604% (minimum 70%, Baseline (adaptation disabled)); retina: 64.1304% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.5556% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 73.7500% (minimum 75%, Baseline (adaptation disabled)); skin: 59.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.2816% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.8352% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.6604% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.2816% (minimum 70%, Baseline (adaptation disabled)); thymus: 45.0382% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.8621% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.0455% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.5556% (minimum 70%, Baseline (adaptation disabled))",-0.199618,-0.186957,-0.223214,0,80,unavailable,5.3,5.6,7.2,"thymus: 7.2 nTPM (manageable, limit 5); thyroid gland: 5.7 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3); bone marrow: 5.3 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.7 nTPM (protected, limit 3); lung: 3.7 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); urinary bladder: 3.1 nTPM (protected, limit 3); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167562,ZNF701,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"liver: 83.3333% (minimum 95%, Enhanced); parathyroid gland: 20.0000% (minimum 80%, Enhanced); retina: 2.7322% (minimum 99%, Missing)",0.05,-0.6,-0.962678,0,3,partial,17.8,2,0,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167612,ANKRD33,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"parathyroid gland: 20.0000% (minimum 55%, Enhanced); retina: 2.7322% (minimum 75%, Missing)",0.35,-0.35,-0.722678,0,3,partial,17.8,2,0,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167612,ANKRD33,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"parathyroid gland: 20.0000% (minimum 55%, Enhanced); retina: 2.7322% (minimum 75%, Missing)",0.35,-0.35,-0.722678,0,3,partial,17.8,2,0,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167612,ANKRD33,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"parathyroid gland: 20.0000% (minimum 55%, Enhanced); retina: 2.7322% (minimum 75%, Missing)",0.35,-0.35,-0.722678,0,3,partial,17.8,2,0,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167612,ANKRD33,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"parathyroid gland: 20.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 2.7322% (minimum 75%, Baseline (adaptation disabled))",0.35,-0.5,-0.722678,0,3,partial,17.8,2,0,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167612,ANKRD33,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.7065% (minimum 95%, Missing); adrenal gland: 47.5806% (minimum 99%, Missing); amygdala: 50.6438% (minimum 99%, Missing); basal ganglia: 46.4567% (minimum 99%, Missing); bone marrow: 51.7544% (minimum 99%, Missing); cerebellum: 42.7536% (minimum 99%, Missing); cerebral cortex: 38.6885% (minimum 99%, Missing); choroid plexus: 49.3724% (minimum 99%, Missing); colon: 52.2124% (minimum 97%, Missing); duodenum: 60.2041% (minimum 99%, Missing); esophagus: 49.5798% (minimum 97%, Missing); heart muscle: 44.6970% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 50.4274% (minimum 99%, Missing); kidney: 46.8254% (minimum 99%, Missing); liver: 51.0823% (minimum 99%, Missing); lung: 56.1905% (minimum 99%, Missing); lymph node: 60.2041% (minimum 97%, Missing); midbrain: 47.5806% (minimum 99%, Missing); pancreas: 50.6438% (minimum 99%, Missing); parathyroid gland: 30.8094% (minimum 97%, Missing); pituitary gland: 36.8750% (minimum 99%, Missing); rectum: 67.0455% (minimum 97%, Missing); retina: 46.0938% (minimum 99%, Missing); salivary gland: 51.0823% (minimum 97%, Missing); skeletal muscle: 26.6968% (minimum 99%, Missing); skin: 51.7544% (minimum 95%, Missing); small intestine: 52.9148% (minimum 99%, Missing); smooth muscle: 63.1016% (minimum 99%, Missing); spinal cord: 46.4567% (minimum 99%, Missing); spleen: 51.7544% (minimum 95%, Missing); stomach: 49.3724% (minimum 97%, Missing); thymus: 51.7544% (minimum 95%, Missing); thyroid gland: 48.5597% (minimum 95%, Missing); tongue: 40.9722% (minimum 97%, Missing); urinary bladder: 52.2124% (minimum 97%, Missing)",-0.464403,-0.661906,-0.723032,0,80,unavailable,32.4,26.5,12.5,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 2); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 2); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); stomach: 12.1 nTPM (protected, limit 2); esophagus: 12 nTPM (protected, limit 2); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 2); thymus: 11 nTPM (manageable, limit 5); spleen: 11 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 2); colon: 10.8 nTPM (protected, limit 2); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); rectum: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167632,TRAPPC9,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.7065% (minimum 65%, Missing); adrenal gland: 47.5806% (minimum 75%, Missing); amygdala: 50.6438% (minimum 75%, Missing); basal ganglia: 46.4567% (minimum 75%, Missing); bone marrow: 51.7544% (minimum 75%, Missing); cerebellum: 42.7536% (minimum 75%, Missing); cerebral cortex: 38.6885% (minimum 75%, Missing); choroid plexus: 49.3724% (minimum 75%, Missing); colon: 52.2124% (minimum 70%, Missing); duodenum: 60.2041% (minimum 75%, Missing); esophagus: 49.5798% (minimum 70%, Missing); heart muscle: 44.6970% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.4274% (minimum 75%, Missing); kidney: 46.8254% (minimum 75%, Missing); liver: 51.0823% (minimum 75%, Missing); lung: 56.1905% (minimum 75%, Missing); lymph node: 60.2041% (minimum 70%, Missing); midbrain: 47.5806% (minimum 75%, Missing); pancreas: 50.6438% (minimum 75%, Missing); parathyroid gland: 30.8094% (minimum 70%, Missing); pituitary gland: 36.8750% (minimum 75%, Missing); rectum: 67.0455% (minimum 70%, Missing); retina: 46.0938% (minimum 75%, Missing); salivary gland: 51.0823% (minimum 70%, Missing); skeletal muscle: 26.6968% (minimum 75%, Missing); skin: 51.7544% (minimum 65%, Missing); small intestine: 52.9148% (minimum 75%, Missing); smooth muscle: 63.1016% (minimum 75%, Missing); spinal cord: 46.4567% (minimum 75%, Missing); spleen: 51.7544% (minimum 65%, Missing); stomach: 49.3724% (minimum 70%, Missing); thymus: 51.7544% (minimum 65%, Missing); thyroid gland: 48.5597% (minimum 65%, Missing); tongue: 40.9722% (minimum 70%, Missing); urinary bladder: 52.2124% (minimum 70%, Missing)",-0.164403,-0.391906,-0.483032,0,80,unavailable,32.4,26.5,12.5,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 2); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 2); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); stomach: 12.1 nTPM (protected, limit 2); esophagus: 12 nTPM (protected, limit 2); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 2); thymus: 11 nTPM (manageable, limit 5); spleen: 11 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 2); colon: 10.8 nTPM (protected, limit 2); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); rectum: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167632,TRAPPC9,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.7065% (minimum 65%, Missing); adrenal gland: 47.5806% (minimum 75%, Missing); amygdala: 50.6438% (minimum 75%, Missing); basal ganglia: 46.4567% (minimum 75%, Missing); bone marrow: 51.7544% (minimum 75%, Missing); cerebellum: 42.7536% (minimum 75%, Missing); cerebral cortex: 38.6885% (minimum 75%, Missing); choroid plexus: 49.3724% (minimum 75%, Missing); colon: 52.2124% (minimum 70%, Missing); duodenum: 60.2041% (minimum 75%, Missing); esophagus: 49.5798% (minimum 70%, Missing); heart muscle: 44.6970% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.4274% (minimum 75%, Missing); kidney: 46.8254% (minimum 75%, Missing); liver: 51.0823% (minimum 75%, Missing); lung: 56.1905% (minimum 75%, Missing); lymph node: 60.2041% (minimum 70%, Missing); midbrain: 47.5806% (minimum 75%, Missing); pancreas: 50.6438% (minimum 75%, Missing); parathyroid gland: 30.8094% (minimum 70%, Missing); pituitary gland: 36.8750% (minimum 75%, Missing); rectum: 67.0455% (minimum 70%, Missing); retina: 46.0938% (minimum 75%, Missing); salivary gland: 51.0823% (minimum 70%, Missing); skeletal muscle: 26.6968% (minimum 75%, Missing); skin: 51.7544% (minimum 65%, Missing); small intestine: 52.9148% (minimum 75%, Missing); smooth muscle: 63.1016% (minimum 75%, Missing); spinal cord: 46.4567% (minimum 75%, Missing); spleen: 51.7544% (minimum 65%, Missing); stomach: 49.3724% (minimum 70%, Missing); thymus: 51.7544% (minimum 65%, Missing); thyroid gland: 48.5597% (minimum 65%, Missing); tongue: 40.9722% (minimum 70%, Missing); urinary bladder: 52.2124% (minimum 70%, Missing)",-0.164403,-0.391906,-0.483032,0,80,unavailable,32.4,26.5,12.5,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 3); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 3); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); stomach: 12.1 nTPM (protected, limit 3); esophagus: 12 nTPM (protected, limit 3); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 3); thymus: 11 nTPM (manageable, limit 5); spleen: 11 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 3); colon: 10.8 nTPM (protected, limit 3); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); rectum: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167632,TRAPPC9,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.7065% (minimum 65%, Missing); adrenal gland: 47.5806% (minimum 75%, Missing); amygdala: 50.6438% (minimum 75%, Missing); basal ganglia: 46.4567% (minimum 75%, Missing); bone marrow: 51.7544% (minimum 75%, Missing); cerebellum: 42.7536% (minimum 75%, Missing); cerebral cortex: 38.6885% (minimum 75%, Missing); choroid plexus: 49.3724% (minimum 75%, Missing); colon: 52.2124% (minimum 70%, Missing); duodenum: 60.2041% (minimum 75%, Missing); esophagus: 49.5798% (minimum 70%, Missing); heart muscle: 44.6970% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.4274% (minimum 75%, Missing); kidney: 46.8254% (minimum 75%, Missing); liver: 51.0823% (minimum 75%, Missing); lung: 56.1905% (minimum 75%, Missing); lymph node: 60.2041% (minimum 70%, Missing); midbrain: 47.5806% (minimum 75%, Missing); pancreas: 50.6438% (minimum 75%, Missing); parathyroid gland: 30.8094% (minimum 70%, Missing); pituitary gland: 36.8750% (minimum 75%, Missing); rectum: 67.0455% (minimum 70%, Missing); retina: 46.0938% (minimum 75%, Missing); salivary gland: 51.0823% (minimum 70%, Missing); skeletal muscle: 26.6968% (minimum 75%, Missing); skin: 51.7544% (minimum 65%, Missing); small intestine: 52.9148% (minimum 75%, Missing); smooth muscle: 63.1016% (minimum 75%, Missing); spinal cord: 46.4567% (minimum 75%, Missing); spleen: 51.7544% (minimum 65%, Missing); stomach: 49.3724% (minimum 70%, Missing); thymus: 51.7544% (minimum 65%, Missing); thyroid gland: 48.5597% (minimum 65%, Missing); tongue: 40.9722% (minimum 70%, Missing); urinary bladder: 52.2124% (minimum 70%, Missing)",-0.164403,-0.391906,-0.483032,0,80,unavailable,32.4,26.5,12.5,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 3); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 3); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); stomach: 12.1 nTPM (protected, limit 3); esophagus: 12 nTPM (protected, limit 3); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 3); thymus: 11 nTPM (manageable, limit 5); spleen: 11 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 3); colon: 10.8 nTPM (protected, limit 3); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); rectum: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167632,TRAPPC9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.7065% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 47.5806% (minimum 75%, Baseline (adaptation disabled)); amygdala: 50.6438% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 46.4567% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 51.7544% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 42.7536% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 38.6885% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 49.3724% (minimum 75%, Baseline (adaptation disabled)); colon: 52.2124% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.2041% (minimum 75%, Baseline (adaptation disabled)); esophagus: 49.5798% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 44.6970% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 50.4274% (minimum 75%, Baseline (adaptation disabled)); kidney: 46.8254% (minimum 75%, Baseline (adaptation disabled)); liver: 51.0823% (minimum 75%, Baseline (adaptation disabled)); lung: 56.1905% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.2041% (minimum 70%, Baseline (adaptation disabled)); midbrain: 47.5806% (minimum 75%, Baseline (adaptation disabled)); pancreas: 50.6438% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 30.8094% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 36.8750% (minimum 75%, Baseline (adaptation disabled)); rectum: 67.0455% (minimum 70%, Baseline (adaptation disabled)); retina: 46.0938% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.0823% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 26.6968% (minimum 75%, Baseline (adaptation disabled)); skin: 51.7544% (minimum 65%, Baseline (adaptation disabled)); small intestine: 52.9148% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.1016% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 46.4567% (minimum 75%, Baseline (adaptation disabled)); spleen: 51.7544% (minimum 65%, Baseline (adaptation disabled)); stomach: 49.3724% (minimum 70%, Baseline (adaptation disabled)); thymus: 51.7544% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 48.5597% (minimum 65%, Baseline (adaptation disabled)); tongue: 40.9722% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.2124% (minimum 70%, Baseline (adaptation disabled))",-0.164403,-0.391906,-0.483032,0,80,unavailable,32.4,26.5,12.5,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 3); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 3); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); stomach: 12.1 nTPM (protected, limit 3); esophagus: 12 nTPM (protected, limit 3); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 3); thymus: 11 nTPM (manageable, limit 5); spleen: 11 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 3); colon: 10.8 nTPM (protected, limit 3); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); rectum: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167632,TRAPPC9,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 95.0000% (minimum 99%, Missing); small intestine: 97.4359% (minimum 99%, Missing); spleen: 86.3636% (minimum 95%, Missing)",-0.0863636,0.00435897,-0.04,0,80,unavailable,0.2,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167634,NLRP7,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
True,compatible,,True,True,True,,0.213636,0.274359,0.2,0,80,unavailable,0.2,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167634,NLRP7,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
True,compatible,,True,True,True,,0.213636,0.274359,0.2,0,80,unavailable,0.2,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167634,NLRP7,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
True,compatible,,True,True,True,,0.213636,0.274359,0.2,0,80,unavailable,0.2,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167634,NLRP7,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
True,compatible,,True,True,True,,0.213636,0.274359,0.2,0,80,unavailable,0.2,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167634,NLRP7,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,7.1,0,0.8,"retina: 7.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000167791,CABP2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,7.1,0,0.8,"retina: 7.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000167791,CABP2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,7.1,0,0.8,"retina: 7.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000167791,CABP2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,7.1,0,0.8,"retina: 7.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000167791,CABP2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,7.1,0,0.8,"retina: 7.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000167791,CABP2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 70.3704% (minimum 90%, Approved); adrenal gland: 67.8571% (minimum 98%, Approved); amygdala: 80.8511% (minimum 99%, Missing); basal ganglia: 76.0000% (minimum 99%, Missing); bone marrow: 67.8571% (minimum 98%, Approved); cerebellum: 74.5098% (minimum 98%, Approved); cerebral cortex: 64.4068% (minimum 99%, Missing); choroid plexus: 79.1667% (minimum 99%, Missing); colon: 77.5510% (minimum 97%, Missing); duodenum: 77.5510% (minimum 98%, Approved); esophagus: 77.5510% (minimum 95%, Approved); heart muscle: 76.0000% (minimum 98%, Approved); hippocampal formation: 80.8511% (minimum 99%, Missing); hypothalamus: 77.5510% (minimum 99%, Missing); kidney: 74.5098% (minimum 99%, Missing); liver: 69.0909% (minimum 98%, Approved); lung: 62.2951% (minimum 98%, Approved); lymph node: 64.4068% (minimum 95%, Approved); midbrain: 80.8511% (minimum 99%, Missing); pancreas: 71.6981% (minimum 98%, Approved); parathyroid gland: 74.5098% (minimum 95%, Approved); pituitary gland: 74.5098% (minimum 99%, Missing); rectum: 80.8511% (minimum 95%, Approved); retina: 62.2951% (minimum 99%, Missing); salivary gland: 79.1667% (minimum 95%, Approved); skeletal muscle: 84.4444% (minimum 98%, Approved); skin: 74.5098% (minimum 90%, Approved); small intestine: 74.5098% (minimum 98%, Approved); smooth muscle: 76.0000% (minimum 98%, Approved); spinal cord: 79.1667% (minimum 99%, Missing); spleen: 67.8571% (minimum 90%, Approved); stomach: 76.0000% (minimum 95%, Approved); thymus: 71.6981% (minimum 95%, Missing); thyroid gland: 66.6667% (minimum 90%, Approved); tongue: 79.1667% (minimum 97%, Missing); urinary bladder: 71.6981% (minimum 95%, Approved)",-0.233333,-0.305932,-0.367049,0,5,partial,2.3,2.1,1.9,"lung: 2.3 nTPM (vital, limit 2); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167981,ZNF597,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.8571% (minimum 70%, Approved); bone marrow: 67.8571% (minimum 70%, Approved); cerebral cortex: 64.4068% (minimum 75%, Missing); kidney: 74.5098% (minimum 75%, Missing); liver: 69.0909% (minimum 70%, Approved); lung: 62.2951% (minimum 70%, Approved); lymph node: 64.4068% (minimum 65%, Approved); pituitary gland: 74.5098% (minimum 75%, Missing); retina: 62.2951% (minimum 75%, Missing)",0.0666667,-0.0059322,-0.127049,0,5,partial,2.3,2.1,1.9,"lung: 2.3 nTPM (vital, limit 2); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167981,ZNF597,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.8571% (minimum 70%, Approved); bone marrow: 67.8571% (minimum 70%, Approved); cerebral cortex: 64.4068% (minimum 75%, Missing); kidney: 74.5098% (minimum 75%, Missing); liver: 69.0909% (minimum 70%, Approved); lung: 62.2951% (minimum 70%, Approved); lymph node: 64.4068% (minimum 65%, Approved); pituitary gland: 74.5098% (minimum 75%, Missing); retina: 62.2951% (minimum 75%, Missing)",0.0666667,-0.0059322,-0.127049,0,5,partial,2.3,2.1,1.9,"lung: 2.3 nTPM (vital, limit 2); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167981,ZNF597,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.8571% (minimum 70%, Approved); bone marrow: 67.8571% (minimum 70%, Approved); cerebral cortex: 64.4068% (minimum 75%, Missing); kidney: 74.5098% (minimum 75%, Missing); liver: 69.0909% (minimum 70%, Approved); lung: 62.2951% (minimum 70%, Approved); lymph node: 64.4068% (minimum 65%, Approved); pituitary gland: 74.5098% (minimum 75%, Missing); retina: 62.2951% (minimum 75%, Missing)",0.0666667,-0.0059322,-0.127049,0,5,partial,2.3,2.1,1.9,"lung: 2.3 nTPM (vital, limit 2); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167981,ZNF597,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.8571% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 67.8571% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.5098% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.4068% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.5098% (minimum 75%, Baseline (adaptation disabled)); liver: 69.0909% (minimum 75%, Baseline (adaptation disabled)); lung: 62.2951% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.4068% (minimum 70%, Baseline (adaptation disabled)); pancreas: 71.6981% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 74.5098% (minimum 75%, Baseline (adaptation disabled)); retina: 62.2951% (minimum 75%, Baseline (adaptation disabled)); small intestine: 74.5098% (minimum 75%, Baseline (adaptation disabled))",0.0166667,-0.0559322,-0.127049,0,5,partial,2.3,2.1,1.9,"lung: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167981,ZNF597,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1056% (minimum 95%, Missing); adrenal gland: 48.6409% (minimum 99%, Missing); amygdala: 59.3368% (minimum 99%, Missing); basal ganglia: 56.7613% (minimum 99%, Missing); bone marrow: 42.9836% (minimum 99%, Missing); cerebellum: 68.0000% (minimum 99%, Missing); cerebral cortex: 58.2192% (minimum 99%, Missing); choroid plexus: 47.6190% (minimum 99%, Missing); colon: 56.3847% (minimum 97%, Missing); duodenum: 58.6207% (minimum 99%, Missing); esophagus: 54.8387% (minimum 97%, Missing); heart muscle: 46.5116% (minimum 99%, Missing); hippocampal formation: 62.8466% (minimum 99%, Missing); hypothalamus: 53.8827% (minimum 99%, Missing); kidney: 48.9209% (minimum 99%, Missing); liver: 42.8752% (minimum 99%, Missing); lung: 59.6491% (minimum 99%, Missing); lymph node: 46.6392% (minimum 97%, Missing); midbrain: 57.4324% (minimum 99%, Missing); pancreas: 59.4406% (minimum 99%, Missing); parathyroid gland: 51.6717% (minimum 97%, Missing); pituitary gland: 46.0081% (minimum 99%, Missing); rectum: 54.6624% (minimum 97%, Missing); retina: 59.9647% (minimum 99%, Missing); salivary gland: 57.1429% (minimum 97%, Missing); skeletal muscle: 47.4860% (minimum 99%, Missing); skin: 57.1429% (minimum 95%, Missing); small intestine: 56.3847% (minimum 99%, Missing); smooth muscle: 56.7613% (minimum 99%, Missing); spinal cord: 61.7060% (minimum 99%, Missing); spleen: 50.0736% (minimum 95%, Missing); stomach: 55.9211% (minimum 97%, Missing); thymus: 47.8873% (minimum 95%, Missing); thyroid gland: 55.0162% (minimum 95%, Missing); tongue: 44.0986% (minimum 97%, Missing); urinary bladder: 51.8293% (minimum 97%, Missing)",-0.471127,-0.529014,-0.561248,0,4,partial,45.3,43.1,37,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 2); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 2); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); thymus: 37 nTPM (manageable, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); spleen: 33.9 nTPM (manageable, limit 5); parathyroid gland: 31.8 nTPM (protected, limit 2); urinary bladder: 31.6 nTPM (protected, limit 2); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 2); esophagus: 28 nTPM (protected, limit 2); thyroid gland: 27.8 nTPM (manageable, limit 5); stomach: 26.8 nTPM (protected, limit 2); adipose tissue: 26.6 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); colon: 26.3 nTPM (protected, limit 2); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); salivary gland: 25.5 nTPM (protected, limit 2); skin: 25.5 nTPM (manageable, limit 5); midbrain: 25.2 nTPM (vital, limit 1); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167985,SDHAF2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1056% (minimum 65%, Missing); adrenal gland: 48.6409% (minimum 75%, Missing); amygdala: 59.3368% (minimum 75%, Missing); basal ganglia: 56.7613% (minimum 75%, Missing); bone marrow: 42.9836% (minimum 75%, Missing); cerebellum: 68.0000% (minimum 75%, Missing); cerebral cortex: 58.2192% (minimum 75%, Missing); choroid plexus: 47.6190% (minimum 75%, Missing); colon: 56.3847% (minimum 70%, Missing); duodenum: 58.6207% (minimum 75%, Missing); esophagus: 54.8387% (minimum 70%, Missing); heart muscle: 46.5116% (minimum 75%, Missing); hippocampal formation: 62.8466% (minimum 75%, Missing); hypothalamus: 53.8827% (minimum 75%, Missing); kidney: 48.9209% (minimum 75%, Missing); liver: 42.8752% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); lymph node: 46.6392% (minimum 70%, Missing); midbrain: 57.4324% (minimum 75%, Missing); pancreas: 59.4406% (minimum 75%, Missing); parathyroid gland: 51.6717% (minimum 70%, Missing); pituitary gland: 46.0081% (minimum 75%, Missing); rectum: 54.6624% (minimum 70%, Missing); retina: 59.9647% (minimum 75%, Missing); salivary gland: 57.1429% (minimum 70%, Missing); skeletal muscle: 47.4860% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); small intestine: 56.3847% (minimum 75%, Missing); smooth muscle: 56.7613% (minimum 75%, Missing); spinal cord: 61.7060% (minimum 75%, Missing); spleen: 50.0736% (minimum 65%, Missing); stomach: 55.9211% (minimum 70%, Missing); thymus: 47.8873% (minimum 65%, Missing); thyroid gland: 55.0162% (minimum 65%, Missing); tongue: 44.0986% (minimum 70%, Missing); urinary bladder: 51.8293% (minimum 70%, Missing)",-0.171127,-0.259014,-0.321248,0,4,partial,45.3,43.1,37,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 2); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 2); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); thymus: 37 nTPM (manageable, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); spleen: 33.9 nTPM (manageable, limit 5); parathyroid gland: 31.8 nTPM (protected, limit 2); urinary bladder: 31.6 nTPM (protected, limit 2); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 2); esophagus: 28 nTPM (protected, limit 2); thyroid gland: 27.8 nTPM (manageable, limit 5); stomach: 26.8 nTPM (protected, limit 2); adipose tissue: 26.6 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); colon: 26.3 nTPM (protected, limit 2); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); salivary gland: 25.5 nTPM (protected, limit 2); skin: 25.5 nTPM (manageable, limit 5); midbrain: 25.2 nTPM (vital, limit 1); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167985,SDHAF2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1056% (minimum 65%, Missing); adrenal gland: 48.6409% (minimum 75%, Missing); amygdala: 59.3368% (minimum 75%, Missing); basal ganglia: 56.7613% (minimum 75%, Missing); bone marrow: 42.9836% (minimum 75%, Missing); cerebellum: 68.0000% (minimum 75%, Missing); cerebral cortex: 58.2192% (minimum 75%, Missing); choroid plexus: 47.6190% (minimum 75%, Missing); colon: 56.3847% (minimum 70%, Missing); duodenum: 58.6207% (minimum 75%, Missing); esophagus: 54.8387% (minimum 70%, Missing); heart muscle: 46.5116% (minimum 75%, Missing); hippocampal formation: 62.8466% (minimum 75%, Missing); hypothalamus: 53.8827% (minimum 75%, Missing); kidney: 48.9209% (minimum 75%, Missing); liver: 42.8752% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); lymph node: 46.6392% (minimum 70%, Missing); midbrain: 57.4324% (minimum 75%, Missing); pancreas: 59.4406% (minimum 75%, Missing); parathyroid gland: 51.6717% (minimum 70%, Missing); pituitary gland: 46.0081% (minimum 75%, Missing); rectum: 54.6624% (minimum 70%, Missing); retina: 59.9647% (minimum 75%, Missing); salivary gland: 57.1429% (minimum 70%, Missing); skeletal muscle: 47.4860% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); small intestine: 56.3847% (minimum 75%, Missing); smooth muscle: 56.7613% (minimum 75%, Missing); spinal cord: 61.7060% (minimum 75%, Missing); spleen: 50.0736% (minimum 65%, Missing); stomach: 55.9211% (minimum 70%, Missing); thymus: 47.8873% (minimum 65%, Missing); thyroid gland: 55.0162% (minimum 65%, Missing); tongue: 44.0986% (minimum 70%, Missing); urinary bladder: 51.8293% (minimum 70%, Missing)",-0.171127,-0.259014,-0.321248,0,4,partial,45.3,43.1,37,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 3); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 3); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); thymus: 37 nTPM (manageable, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); spleen: 33.9 nTPM (manageable, limit 5); parathyroid gland: 31.8 nTPM (protected, limit 3); urinary bladder: 31.6 nTPM (protected, limit 3); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 3); esophagus: 28 nTPM (protected, limit 3); thyroid gland: 27.8 nTPM (manageable, limit 5); stomach: 26.8 nTPM (protected, limit 3); adipose tissue: 26.6 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); colon: 26.3 nTPM (protected, limit 3); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); salivary gland: 25.5 nTPM (protected, limit 3); skin: 25.5 nTPM (manageable, limit 5); midbrain: 25.2 nTPM (vital, limit 1); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167985,SDHAF2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1056% (minimum 65%, Missing); adrenal gland: 48.6409% (minimum 75%, Missing); amygdala: 59.3368% (minimum 75%, Missing); basal ganglia: 56.7613% (minimum 75%, Missing); bone marrow: 42.9836% (minimum 75%, Missing); cerebellum: 68.0000% (minimum 75%, Missing); cerebral cortex: 58.2192% (minimum 75%, Missing); choroid plexus: 47.6190% (minimum 75%, Missing); colon: 56.3847% (minimum 70%, Missing); duodenum: 58.6207% (minimum 75%, Missing); esophagus: 54.8387% (minimum 70%, Missing); heart muscle: 46.5116% (minimum 75%, Missing); hippocampal formation: 62.8466% (minimum 75%, Missing); hypothalamus: 53.8827% (minimum 75%, Missing); kidney: 48.9209% (minimum 75%, Missing); liver: 42.8752% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); lymph node: 46.6392% (minimum 70%, Missing); midbrain: 57.4324% (minimum 75%, Missing); pancreas: 59.4406% (minimum 75%, Missing); parathyroid gland: 51.6717% (minimum 70%, Missing); pituitary gland: 46.0081% (minimum 75%, Missing); rectum: 54.6624% (minimum 70%, Missing); retina: 59.9647% (minimum 75%, Missing); salivary gland: 57.1429% (minimum 70%, Missing); skeletal muscle: 47.4860% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); small intestine: 56.3847% (minimum 75%, Missing); smooth muscle: 56.7613% (minimum 75%, Missing); spinal cord: 61.7060% (minimum 75%, Missing); spleen: 50.0736% (minimum 65%, Missing); stomach: 55.9211% (minimum 70%, Missing); thymus: 47.8873% (minimum 65%, Missing); thyroid gland: 55.0162% (minimum 65%, Missing); tongue: 44.0986% (minimum 70%, Missing); urinary bladder: 51.8293% (minimum 70%, Missing)",-0.171127,-0.259014,-0.321248,0,4,partial,45.3,43.1,37,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 3); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 3); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); thymus: 37 nTPM (manageable, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); spleen: 33.9 nTPM (manageable, limit 5); parathyroid gland: 31.8 nTPM (protected, limit 3); urinary bladder: 31.6 nTPM (protected, limit 3); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 3); esophagus: 28 nTPM (protected, limit 3); thyroid gland: 27.8 nTPM (manageable, limit 5); stomach: 26.8 nTPM (protected, limit 3); adipose tissue: 26.6 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); colon: 26.3 nTPM (protected, limit 3); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); salivary gland: 25.5 nTPM (protected, limit 3); skin: 25.5 nTPM (manageable, limit 5); midbrain: 25.2 nTPM (vital, limit 1); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167985,SDHAF2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1056% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 48.6409% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.3368% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.7613% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 42.9836% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.2192% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 47.6190% (minimum 75%, Baseline (adaptation disabled)); colon: 56.3847% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.6207% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.8387% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 46.5116% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 62.8466% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.8827% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.9209% (minimum 75%, Baseline (adaptation disabled)); liver: 42.8752% (minimum 75%, Baseline (adaptation disabled)); lung: 59.6491% (minimum 75%, Baseline (adaptation disabled)); lymph node: 46.6392% (minimum 70%, Baseline (adaptation disabled)); midbrain: 57.4324% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.4406% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.6717% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 46.0081% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.6624% (minimum 70%, Baseline (adaptation disabled)); retina: 59.9647% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 57.1429% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 47.4860% (minimum 75%, Baseline (adaptation disabled)); skin: 57.1429% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.3847% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.7613% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.7060% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0736% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.9211% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.8873% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.0162% (minimum 65%, Baseline (adaptation disabled)); tongue: 44.0986% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.8293% (minimum 70%, Baseline (adaptation disabled))",-0.171127,-0.259014,-0.321248,0,4,partial,45.3,43.1,37,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 3); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 3); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); thymus: 37 nTPM (manageable, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); spleen: 33.9 nTPM (manageable, limit 5); parathyroid gland: 31.8 nTPM (protected, limit 3); urinary bladder: 31.6 nTPM (protected, limit 3); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 3); esophagus: 28 nTPM (protected, limit 3); thyroid gland: 27.8 nTPM (manageable, limit 5); stomach: 26.8 nTPM (protected, limit 3); adipose tissue: 26.6 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); colon: 26.3 nTPM (protected, limit 3); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); salivary gland: 25.5 nTPM (protected, limit 3); skin: 25.5 nTPM (manageable, limit 5); midbrain: 25.2 nTPM (vital, limit 1); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000167985,SDHAF2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.6755% (minimum 99%, Missing); retina: 98.0263% (minimum 99%, Missing)",0.0389381,0.0233333,-0.00973684,0,3,partial,1.2,0.8,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168026,TTC21A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338938,0.293333,0.230263,0,3,partial,1.2,0.8,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168026,TTC21A,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338938,0.293333,0.230263,0,3,partial,1.2,0.8,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168026,TTC21A,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338938,0.293333,0.230263,0,3,partial,1.2,0.8,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168026,TTC21A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336755,0.282418,0.223856,0,3,partial,1.2,0.8,0.6,"pancreas: 1.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168026,TTC21A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.7233% (minimum 95%, Missing); adrenal gland: 88.3268% (minimum 99%, Missing); amygdala: 94.9791% (minimum 99%, Missing); basal ganglia: 94.9791% (minimum 99%, Missing); bone marrow: 72.9904% (minimum 99%, Missing); cerebellum: 97.4249% (minimum 99%, Missing); cerebral cortex: 95.7806% (minimum 99%, Missing); choroid plexus: 76.4310% (minimum 99%, Missing); colon: 93.4156% (minimum 97%, Missing); duodenum: 95.3782% (minimum 99%, Missing); esophagus: 93.8017% (minimum 97%, Missing); heart muscle: 73.2258% (minimum 99%, Missing); hippocampal formation: 94.5833% (minimum 99%, Missing); hypothalamus: 94.1909% (minimum 99%, Missing); kidney: 85.9848% (minimum 99%, Missing); liver: 91.9028% (minimum 99%, Missing); lung: 86.9732% (minimum 99%, Missing); lymph node: 88.3268% (minimum 97%, Missing); midbrain: 95.3782% (minimum 99%, Missing); pancreas: 92.2764% (minimum 99%, Uncertain); parathyroid gland: 74.6711% (minimum 97%, Missing); pituitary gland: 89.0196% (minimum 99%, Missing); rectum: 93.4156% (minimum 97%, Missing); retina: 79.6491% (minimum 99%, Missing); salivary gland: 93.4156% (minimum 97%, Missing); skeletal muscle: 98.2684% (minimum 99%, Missing); skin: 91.5323% (minimum 95%, Missing); small intestine: 92.2764% (minimum 99%, Missing); smooth muscle: 86.9732% (minimum 99%, Missing); spinal cord: 94.5833% (minimum 99%, Missing); spleen: 91.9028% (minimum 95%, Missing); stomach: 90.8000% (minimum 97%, Missing); thymus: 88.6719% (minimum 95%, Missing); thyroid gland: 82.8467% (minimum 95%, Missing); urinary bladder: 92.6531% (minimum 97%, Uncertain)",-0.121533,-0.223289,-0.260096,0,2,partial,8.4,7.7,4.7,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168038,ULK4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 72.9904% (minimum 75%, Missing); heart muscle: 73.2258% (minimum 75%, Missing)",0.178467,0.0467105,-0.0200965,0,2,partial,8.4,7.7,4.7,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168038,ULK4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 72.9904% (minimum 75%, Missing); heart muscle: 73.2258% (minimum 75%, Missing)",0.178467,0.0467105,-0.0200965,0,2,partial,8.4,7.7,4.7,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 3); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168038,ULK4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 72.9904% (minimum 75%, Missing); heart muscle: 73.2258% (minimum 75%, Missing)",0.178467,0.0467105,-0.0200965,0,2,partial,8.4,7.7,4.7,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 3); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168038,ULK4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 72.9904% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 73.2258% (minimum 75%, Baseline (adaptation disabled))",0.178467,0.0467105,-0.0200965,0,2,partial,8.4,7.7,4.7,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 3); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168038,ULK4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.9762% (minimum 95%, Missing); adrenal gland: 79.8780% (minimum 99%, Missing); amygdala: 84.5161% (minimum 99%, Missing); basal ganglia: 82.9114% (minimum 99%, Missing); bone marrow: 76.6082% (minimum 99%, Uncertain); cerebellum: 73.5955% (minimum 99%, Missing); cerebral cortex: 83.4395% (minimum 99%, Missing); choroid plexus: 65.8291% (minimum 99%, Missing); colon: 78.9157% (minimum 97%, Missing); duodenum: 80.8642% (minimum 99%, Missing); esophagus: 78.9157% (minimum 97%, Missing); heart muscle: 83.9744% (minimum 99%, Missing); hippocampal formation: 83.9744% (minimum 99%, Missing); hypothalamus: 85.0649% (minimum 99%, Missing); kidney: 86.7550% (minimum 99%, Missing); liver: 78.4431% (minimum 99%, Missing); lung: 86.7550% (minimum 99%, Missing); lymph node: 82.9114% (minimum 97%, Missing); midbrain: 85.0649% (minimum 99%, Missing); pancreas: 82.9114% (minimum 99%, Missing); parathyroid gland: 91.6084% (minimum 97%, Missing); pituitary gland: 82.9114% (minimum 99%, Missing); rectum: 91.6084% (minimum 97%, Missing); retina: 96.3235% (minimum 99%, Missing); salivary gland: 83.4395% (minimum 97%, Missing); skeletal muscle: 59.5455% (minimum 99%, Missing); skin: 78.4431% (minimum 95%, Missing); small intestine: 83.9744% (minimum 99%, Missing); smooth muscle: 87.3333% (minimum 99%, Missing); spinal cord: 84.5161% (minimum 99%, Missing); spleen: 81.3665% (minimum 95%, Missing); stomach: 82.3899% (minimum 97%, Missing); thymus: 65.5000% (minimum 95%, Missing); thyroid gland: 90.9722% (minimum 95%, Missing); tongue: 86.1842% (minimum 97%, Missing); urinary bladder: 83.9744% (minimum 97%, Missing)",-0.295,-0.180843,-0.394545,0,7,partial,8.9,3.5,6.9,"skeletal muscle: 8.9 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168061,SAC3D1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 73.5955% (minimum 75%, Missing); choroid plexus: 65.8291% (minimum 75%, Missing); skeletal muscle: 59.5455% (minimum 75%, Missing)",0.005,0.0891566,-0.154545,0,7,partial,8.9,3.5,6.9,"skeletal muscle: 8.9 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168061,SAC3D1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 73.5955% (minimum 75%, Missing); choroid plexus: 65.8291% (minimum 75%, Missing); skeletal muscle: 59.5455% (minimum 75%, Missing)",0.005,0.0891566,-0.154545,0,7,partial,8.9,3.5,6.9,"skeletal muscle: 8.9 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168061,SAC3D1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 73.5955% (minimum 75%, Missing); choroid plexus: 65.8291% (minimum 75%, Missing); skeletal muscle: 59.5455% (minimum 75%, Missing)",0.005,0.0891566,-0.154545,0,7,partial,8.9,3.5,6.9,"skeletal muscle: 8.9 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168061,SAC3D1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 73.5955% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 65.8291% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 59.5455% (minimum 75%, Baseline (adaptation disabled))",0.005,0.0891566,-0.154545,0,7,partial,8.9,3.5,6.9,"skeletal muscle: 8.9 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168061,SAC3D1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.1982% (minimum 99%, Missing); kidney: 94.3723% (minimum 99%, Missing); liver: 95.1965% (minimum 99%, Missing); lymph node: 93.9655% (minimum 97%, Missing); pancreas: 98.6425% (minimum 99%, Missing); skin: 94.7826% (minimum 95%, Missing); small intestine: 98.1982% (minimum 99%, Missing)",-0.00217391,-0.0303448,-0.0462771,0,80,unavailable,1.3,1.4,1.2,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168070,MAJIN,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297826,0.239655,0.193723,0,80,unavailable,1.3,1.4,1.2,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168070,MAJIN,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297826,0.239655,0.193723,0,80,unavailable,1.3,1.4,1.2,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168070,MAJIN,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297826,0.239655,0.193723,0,80,unavailable,1.3,1.4,1.2,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168070,MAJIN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297826,0.239655,0.193723,0,80,unavailable,1.3,1.4,1.2,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168070,MAJIN,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 88.3420% (minimum 95%, Enhanced); duodenum: 89.3840% (minimum 95%, Enhanced); lymph node: 84.5105% (minimum 97%, Missing); small intestine: 89.6189% (minimum 95%, Enhanced); thymus: 75.4425% (minimum 95%, Missing)",-0.195575,-0.124895,-0.0665803,0,3,partial,9,12.5,22.2,"thymus: 22.2 nTPM (manageable, limit 5); lymph node: 12.5 nTPM (protected, limit 2); bone marrow: 9 nTPM (vital, limit 6); duodenum: 8.1 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6)",lymph node / germinal center cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168078,PBK,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.104425,0.145105,0.248536,0,3,partial,9,12.5,22.2,"thymus: 22.2 nTPM (manageable, limit 5); lymph node: 12.5 nTPM (protected, limit 2); bone marrow: 9 nTPM (vital, limit 6); duodenum: 8.1 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6)",lymph node / germinal center cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168078,PBK,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.104425,0.145105,0.248536,0,3,partial,9,12.5,22.2,"thymus: 22.2 nTPM (manageable, limit 5); lymph node: 12.5 nTPM (protected, limit 3); bone marrow: 9 nTPM (vital, limit 6); duodenum: 8.1 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6)",lymph node / germinal center cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168078,PBK,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.104425,0.145105,0.248536,0,3,partial,9,12.5,22.2,"thymus: 22.2 nTPM (manageable, limit 5); lymph node: 12.5 nTPM (protected, limit 3); bone marrow: 9 nTPM (vital, limit 6); duodenum: 8.1 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6)",lymph node / germinal center cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168078,PBK,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.104425,0.145105,0.13342,0,3,partial,9,12.5,22.2,"thymus: 22.2 nTPM (manageable, limit 5); lymph node: 12.5 nTPM (protected, limit 3); rectum: 9.8 nTPM (protected, limit 3); bone marrow: 9 nTPM (vital, limit 1); colon: 8.6 nTPM (protected, limit 3); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 2.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168078,PBK,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.0000% (minimum 90%, Approved); adrenal gland: 66.4234% (minimum 98%, Approved); amygdala: 79.8246% (minimum 99%, Missing); basal ganglia: 79.1304% (minimum 99%, Missing); bone marrow: 52.0000% (minimum 98%, Approved); cerebellum: 67.4074% (minimum 98%, Approved); cerebral cortex: 60.6667% (minimum 99%, Missing); choroid plexus: 90.0990% (minimum 99%, Missing); colon: 76.4706% (minimum 97%, Missing); duodenum: 81.2500% (minimum 99%, Missing); esophagus: 73.9837% (minimum 97%, Missing); heart muscle: 72.8000% (minimum 99%, Missing); hippocampal formation: 79.1304% (minimum 99%, Missing); hypothalamus: 74.5902% (minimum 99%, Missing); kidney: 72.2222% (minimum 99%, Missing); liver: 65.4676% (minimum 98%, Approved); lung: 77.1186% (minimum 98%, Approved); lymph node: 66.9118% (minimum 95%, Approved); midbrain: 80.5310% (minimum 99%, Missing); pancreas: 77.1186% (minimum 99%, Missing); parathyroid gland: 64.0845% (minimum 95%, Approved); pituitary gland: 71.6535% (minimum 99%, Missing); rectum: 78.4483% (minimum 97%, Missing); retina: 70.5426% (minimum 99%, Missing); salivary gland: 77.7778% (minimum 97%, Missing); skeletal muscle: 85.8491% (minimum 99%, Missing); skin: 79.1304% (minimum 95%, Missing); small intestine: 79.1304% (minimum 98%, Approved); smooth muscle: 68.4211% (minimum 99%, Missing); spinal cord: 79.8246% (minimum 99%, Missing); spleen: 67.4074% (minimum 90%, Approved); stomach: 81.9820% (minimum 97%, Missing); thymus: 61.4865% (minimum 95%, Missing); thyroid gland: 62.3288% (minimum 90%, Approved); tongue: 73.9837% (minimum 97%, Missing); urinary bladder: 66.4234% (minimum 97%, Missing)",-0.335135,-0.309155,-0.46,0,4,partial,8.4,5.1,5.7,"bone marrow: 8.4 nTPM (vital, limit 2); cerebral cortex: 5.9 nTPM (vital, limit 1); thymus: 5.7 nTPM (manageable, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 4); liver: 4.8 nTPM (vital, limit 2); adrenal gland: 4.6 nTPM (vital, limit 2); urinary bladder: 4.6 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 4); cerebellum: 4.4 nTPM (vital, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); hypothalamus: 3.1 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 2); pancreas: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); hippocampal formation: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168116,KIAA1586,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.4234% (minimum 70%, Approved); bone marrow: 52.0000% (minimum 70%, Approved); cerebellum: 67.4074% (minimum 70%, Approved); cerebral cortex: 60.6667% (minimum 75%, Missing); heart muscle: 72.8000% (minimum 75%, Missing); hypothalamus: 74.5902% (minimum 75%, Missing); kidney: 72.2222% (minimum 75%, Missing); liver: 65.4676% (minimum 70%, Approved); parathyroid gland: 64.0845% (minimum 65%, Approved); pituitary gland: 71.6535% (minimum 75%, Missing); retina: 70.5426% (minimum 75%, Missing); smooth muscle: 68.4211% (minimum 75%, Missing); thymus: 61.4865% (minimum 65%, Missing); urinary bladder: 66.4234% (minimum 70%, Missing)",-0.0351351,-0.0357664,-0.18,0,4,partial,8.4,5.1,5.7,"bone marrow: 8.4 nTPM (vital, limit 2); cerebral cortex: 5.9 nTPM (vital, limit 1); thymus: 5.7 nTPM (manageable, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 4); liver: 4.8 nTPM (vital, limit 2); adrenal gland: 4.6 nTPM (vital, limit 2); urinary bladder: 4.6 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 4); cerebellum: 4.4 nTPM (vital, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); hypothalamus: 3.1 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 2); pancreas: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); hippocampal formation: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168116,KIAA1586,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.4234% (minimum 70%, Approved); bone marrow: 52.0000% (minimum 70%, Approved); cerebellum: 67.4074% (minimum 70%, Approved); cerebral cortex: 60.6667% (minimum 75%, Missing); heart muscle: 72.8000% (minimum 75%, Missing); hypothalamus: 74.5902% (minimum 75%, Missing); kidney: 72.2222% (minimum 75%, Missing); liver: 65.4676% (minimum 70%, Approved); parathyroid gland: 64.0845% (minimum 65%, Approved); pituitary gland: 71.6535% (minimum 75%, Missing); retina: 70.5426% (minimum 75%, Missing); smooth muscle: 68.4211% (minimum 75%, Missing); thymus: 61.4865% (minimum 65%, Missing); urinary bladder: 66.4234% (minimum 70%, Missing)",-0.0351351,-0.0357664,-0.18,0,4,partial,8.4,5.1,5.7,"bone marrow: 8.4 nTPM (vital, limit 2); cerebral cortex: 5.9 nTPM (vital, limit 1); thymus: 5.7 nTPM (manageable, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 4); liver: 4.8 nTPM (vital, limit 2); adrenal gland: 4.6 nTPM (vital, limit 2); urinary bladder: 4.6 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 4); cerebellum: 4.4 nTPM (vital, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 2); small intestine: 2.4 nTPM (vital, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168116,KIAA1586,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.4234% (minimum 70%, Approved); bone marrow: 52.0000% (minimum 70%, Approved); cerebellum: 67.4074% (minimum 70%, Approved); cerebral cortex: 60.6667% (minimum 75%, Missing); heart muscle: 72.8000% (minimum 75%, Missing); hypothalamus: 74.5902% (minimum 75%, Missing); kidney: 72.2222% (minimum 75%, Missing); liver: 65.4676% (minimum 70%, Approved); parathyroid gland: 64.0845% (minimum 65%, Approved); pituitary gland: 71.6535% (minimum 75%, Missing); retina: 70.5426% (minimum 75%, Missing); smooth muscle: 68.4211% (minimum 75%, Missing); thymus: 61.4865% (minimum 65%, Missing); urinary bladder: 66.4234% (minimum 70%, Missing)",-0.0351351,-0.0357664,-0.18,0,4,partial,8.4,5.1,5.7,"bone marrow: 8.4 nTPM (vital, limit 2); cerebral cortex: 5.9 nTPM (vital, limit 1); thymus: 5.7 nTPM (manageable, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 4); liver: 4.8 nTPM (vital, limit 2); adrenal gland: 4.6 nTPM (vital, limit 2); urinary bladder: 4.6 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 4); cerebellum: 4.4 nTPM (vital, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 2); small intestine: 2.4 nTPM (vital, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168116,KIAA1586,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.4234% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 52.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.4074% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.6667% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 72.8000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.5902% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.2222% (minimum 75%, Baseline (adaptation disabled)); liver: 65.4676% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.9118% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 64.0845% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.6535% (minimum 75%, Baseline (adaptation disabled)); retina: 70.5426% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.4211% (minimum 75%, Baseline (adaptation disabled)); thymus: 61.4865% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.3288% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 66.4234% (minimum 70%, Baseline (adaptation disabled))",-0.0351351,-0.0591549,-0.23,0,4,partial,8.4,5.1,5.7,"bone marrow: 8.4 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); thymus: 5.7 nTPM (manageable, limit 5); thyroid gland: 5.5 nTPM (manageable, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 3); liver: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 3); cerebellum: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168116,KIAA1586,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"cerebellum: 93.7500% (minimum 99%, Missing); colon: 96.7742% (minimum 97%, Missing); salivary gland: 96.7742% (minimum 97%, Missing); small intestine: 96.7742% (minimum 99%, Missing); urinary bladder: 96.7742% (minimum 97%, Missing)",0.05,-0.00225806,-0.0525,0,6,partial,0.2,0.1,0,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168148,H3-4,admission_only,False,False,False,False,10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.35,0.267742,0.1875,0,6,partial,0.2,0.1,0,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168148,H3-4,selectivity_revised,False,False,False,False,10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.35,0.267742,0.1875,0,6,partial,0.2,0.1,0,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168148,H3-4,grid_revised,False,False,False,False,10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.35,0.267742,0.1875,0,6,partial,0.2,0.1,0,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168148,H3-4,current_adaptive,False,False,False,False,10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.35,0.267742,0.1875,0,6,partial,0.2,0.1,0,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168148,H3-4,current_fixed,False,False,False,False,10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Missing); adrenal gland: 81.2500% (minimum 99%, Missing); amygdala: 74.7126% (minimum 99%, Missing); basal ganglia: 74.7126% (minimum 99%, Missing); bone marrow: 76.4706% (minimum 99%, Missing); cerebellum: 78.3133% (minimum 99%, Missing); cerebral cortex: 76.4706% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 81.2500% (minimum 97%, Missing); duodenum: 82.2785% (minimum 99%, Missing); esophagus: 84.4156% (minimum 97%, Missing); heart muscle: 71.4286% (minimum 99%, Missing); hippocampal formation: 71.4286% (minimum 99%, Missing); hypothalamus: 76.4706% (minimum 99%, Missing); kidney: 69.1489% (minimum 99%, Missing); liver: 67.7083% (minimum 99%, Missing); lung: 80.2469% (minimum 99%, Missing); lymph node: 79.2683% (minimum 97%, Missing); midbrain: 69.8925% (minimum 99%, Missing); pancreas: 73.0337% (minimum 99%, Missing); parathyroid gland: 67.7083% (minimum 97%, Missing); pituitary gland: 71.4286% (minimum 99%, Missing); rectum: 80.2469% (minimum 97%, Missing); retina: 60.7477% (minimum 99%, Missing); salivary gland: 76.4706% (minimum 97%, Missing); skeletal muscle: 56.5217% (minimum 99%, Missing); skin: 79.2683% (minimum 95%, Missing); small intestine: 82.2785% (minimum 99%, Missing); smooth muscle: 82.2785% (minimum 99%, Missing); spinal cord: 65.0000% (minimum 99%, Missing); spleen: 82.2785% (minimum 95%, Missing); stomach: 82.2785% (minimum 97%, Missing); thymus: 73.0337% (minimum 95%, Missing); thyroid gland: 61.9048% (minimum 95%, Missing); tongue: 49.6183% (minimum 97%, Missing); urinary bladder: 81.2500% (minimum 97%, Missing)",-0.330952,-0.473817,-0.424783,0,2,partial,5,6.6,4,"tongue: 6.6 nTPM (protected, limit 2); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168152,THAP9,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 74.7126% (minimum 75%, Missing); basal ganglia: 74.7126% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); kidney: 69.1489% (minimum 75%, Missing); liver: 67.7083% (minimum 75%, Missing); midbrain: 69.8925% (minimum 75%, Missing); pancreas: 73.0337% (minimum 75%, Missing); parathyroid gland: 67.7083% (minimum 70%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 60.7477% (minimum 75%, Missing); skeletal muscle: 56.5217% (minimum 75%, Missing); spinal cord: 65.0000% (minimum 75%, Missing); thyroid gland: 61.9048% (minimum 65%, Missing); tongue: 49.6183% (minimum 70%, Missing)",-0.0309524,-0.203817,-0.184783,0,2,partial,5,6.6,4,"tongue: 6.6 nTPM (protected, limit 2); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168152,THAP9,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 74.7126% (minimum 75%, Missing); basal ganglia: 74.7126% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); kidney: 69.1489% (minimum 75%, Missing); liver: 67.7083% (minimum 75%, Missing); midbrain: 69.8925% (minimum 75%, Missing); pancreas: 73.0337% (minimum 75%, Missing); parathyroid gland: 67.7083% (minimum 70%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 60.7477% (minimum 75%, Missing); skeletal muscle: 56.5217% (minimum 75%, Missing); spinal cord: 65.0000% (minimum 75%, Missing); thyroid gland: 61.9048% (minimum 65%, Missing); tongue: 49.6183% (minimum 70%, Missing)",-0.0309524,-0.203817,-0.184783,0,2,partial,5,6.6,4,"tongue: 6.6 nTPM (protected, limit 3); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168152,THAP9,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 74.7126% (minimum 75%, Missing); basal ganglia: 74.7126% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); kidney: 69.1489% (minimum 75%, Missing); liver: 67.7083% (minimum 75%, Missing); midbrain: 69.8925% (minimum 75%, Missing); pancreas: 73.0337% (minimum 75%, Missing); parathyroid gland: 67.7083% (minimum 70%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 60.7477% (minimum 75%, Missing); skeletal muscle: 56.5217% (minimum 75%, Missing); spinal cord: 65.0000% (minimum 75%, Missing); thyroid gland: 61.9048% (minimum 65%, Missing); tongue: 49.6183% (minimum 70%, Missing)",-0.0309524,-0.203817,-0.184783,0,2,partial,5,6.6,4,"tongue: 6.6 nTPM (protected, limit 3); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168152,THAP9,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 74.7126% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.7126% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.4286% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.1489% (minimum 75%, Baseline (adaptation disabled)); liver: 67.7083% (minimum 75%, Baseline (adaptation disabled)); midbrain: 69.8925% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.0337% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 67.7083% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.4286% (minimum 75%, Baseline (adaptation disabled)); retina: 60.7477% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 56.5217% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.0000% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 61.9048% (minimum 65%, Baseline (adaptation disabled)); tongue: 49.6183% (minimum 70%, Baseline (adaptation disabled))",-0.0309524,-0.203817,-0.184783,0,2,partial,5,6.6,4,"tongue: 6.6 nTPM (protected, limit 3); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168152,THAP9,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 95.9184% (minimum 99%, Missing); cerebellum: 92.1569% (minimum 95%, Enhanced); retina: 1.6491% (minimum 99%, Missing)",0.05,0.03,-0.973509,0,1,partial,280.3,0.1,0.1,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),61,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168263,KCNV2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 1.6491% (minimum 75%, Missing)",0.35,0.3,-0.733509,0,1,partial,280.3,0.1,0.1,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),61,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168263,KCNV2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 1.6491% (minimum 75%, Missing)",0.35,0.3,-0.733509,0,1,partial,280.3,0.1,0.1,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),61,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168263,KCNV2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 1.6491% (minimum 75%, Missing)",0.35,0.3,-0.733509,0,1,partial,280.3,0.1,0.1,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),61,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168263,KCNV2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 1.6491% (minimum 75%, Baseline (adaptation disabled))",0.329167,0.279167,-0.733509,0,1,partial,280.3,0.1,0.1,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),61,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168263,KCNV2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); cerebellum: 91.3043% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); heart muscle: 87.5000% (minimum 99%, Missing); hippocampal formation: 80.7692% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); midbrain: 91.3043% (minimum 99%, Missing); pancreas: 2.0329% (minimum 99%, Missing); pituitary gland: 91.3043% (minimum 99%, Missing); retina: 95.4545% (minimum 99%, Missing); salivary gland: 95.4545% (minimum 97%, Missing); small intestine: 95.4545% (minimum 99%, Missing); smooth muscle: 91.3043% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); stomach: 52.5000% (minimum 97%, Missing)",0.05,-0.445,-0.969671,0,80,unavailable,101.2,1.9,0,"pancreas: 101.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168267,PTF1A,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 2.0329% (minimum 75%, Missing); stomach: 52.5000% (minimum 70%, Missing)",0.35,-0.175,-0.729671,0,80,unavailable,101.2,1.9,0,"pancreas: 101.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168267,PTF1A,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 2.0329% (minimum 75%, Missing); stomach: 52.5000% (minimum 70%, Missing)",0.35,-0.175,-0.729671,0,80,unavailable,101.2,1.9,0,"pancreas: 101.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168267,PTF1A,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 2.0329% (minimum 75%, Missing); stomach: 52.5000% (minimum 70%, Missing)",0.35,-0.175,-0.729671,0,80,unavailable,101.2,1.9,0,"pancreas: 101.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168267,PTF1A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 2.0329% (minimum 75%, Baseline (adaptation disabled)); stomach: 52.5000% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.175,-0.729671,0,80,unavailable,101.2,1.9,0,"pancreas: 101.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168267,PTF1A,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 2.8711% (minimum 99%, Missing); basal ganglia: 4.0091% (minimum 99%, Missing); cerebellum: 20.3065% (minimum 95%, Enhanced); cerebral cortex: 4.9165% (minimum 99%, Missing); choroid plexus: 9.3805% (minimum 99%, Missing); hippocampal formation: 1.9835% (minimum 99%, Missing); hypothalamus: 2.8836% (minimum 99%, Missing); kidney: 94.6429% (minimum 95%, Enhanced); lung: 89.8305% (minimum 95%, Enhanced); midbrain: 1.2206% (minimum 99%, Missing); parathyroid gland: 69.7368% (minimum 80%, Enhanced); pituitary gland: 94.6429% (minimum 99%, Missing); retina: 96.3636% (minimum 99%, Missing); spinal cord: 0.4854% (minimum 99%, Missing)",0.05,-0.102632,-0.985146,0,2,partial,1086.6,2.3,0.2,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 6)",cerebral cortex / neuropil: Medium (Enhanced),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168314,MOBP,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 2.8711% (minimum 75%, Missing); basal ganglia: 4.0091% (minimum 75%, Missing); cerebellum: 20.3065% (minimum 60%, Enhanced); cerebral cortex: 4.9165% (minimum 75%, Missing); choroid plexus: 9.3805% (minimum 75%, Missing); hippocampal formation: 1.9835% (minimum 75%, Missing); hypothalamus: 2.8836% (minimum 75%, Missing); midbrain: 1.2206% (minimum 75%, Missing); spinal cord: 0.4854% (minimum 75%, Missing)",0.35,0.147368,-0.745146,0,2,partial,1086.6,2.3,0.2,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 6)",cerebral cortex / neuropil: Medium (Enhanced),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168314,MOBP,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 2.8711% (minimum 75%, Missing); basal ganglia: 4.0091% (minimum 75%, Missing); cerebellum: 20.3065% (minimum 60%, Enhanced); cerebral cortex: 4.9165% (minimum 75%, Missing); choroid plexus: 9.3805% (minimum 75%, Missing); hippocampal formation: 1.9835% (minimum 75%, Missing); hypothalamus: 2.8836% (minimum 75%, Missing); midbrain: 1.2206% (minimum 75%, Missing); spinal cord: 0.4854% (minimum 75%, Missing)",0.35,0.147368,-0.745146,0,2,partial,1086.6,2.3,0.2,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 6)",cerebral cortex / neuropil: Medium (Enhanced),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168314,MOBP,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 2.8711% (minimum 75%, Missing); basal ganglia: 4.0091% (minimum 75%, Missing); cerebellum: 20.3065% (minimum 60%, Enhanced); cerebral cortex: 4.9165% (minimum 75%, Missing); choroid plexus: 9.3805% (minimum 75%, Missing); hippocampal formation: 1.9835% (minimum 75%, Missing); hypothalamus: 2.8836% (minimum 75%, Missing); midbrain: 1.2206% (minimum 75%, Missing); spinal cord: 0.4854% (minimum 75%, Missing)",0.35,0.147368,-0.745146,0,2,partial,1086.6,2.3,0.2,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 6)",cerebral cortex / neuropil: Medium (Enhanced),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168314,MOBP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 2.8711% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 4.0091% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 20.3065% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 4.9165% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 9.3805% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 1.9835% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 2.8836% (minimum 75%, Baseline (adaptation disabled)); midbrain: 1.2206% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.7368% (minimum 70%, Baseline (adaptation disabled)); spinal cord: 0.4854% (minimum 75%, Baseline (adaptation disabled))",0.313636,-0.00263158,-0.745146,0,2,partial,1086.6,2.3,0.2,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 1)",cerebral cortex / neuropil: Medium (Enhanced),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168314,MOBP,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.0281% (minimum 95%, Missing); adrenal gland: 50.0000% (minimum 99%, Missing); amygdala: 65.4378% (minimum 99%, Missing); basal ganglia: 50.0000% (minimum 99%, Missing); bone marrow: 27.3603% (minimum 99%, Missing); cerebellum: 62.2807% (minimum 99%, Missing); cerebral cortex: 52.3985% (minimum 99%, Missing); choroid plexus: 68.2692% (minimum 99%, Missing); colon: 57.0281% (minimum 97%, Missing); duodenum: 57.0281% (minimum 99%, Missing); esophagus: 57.7236% (minimum 97%, Missing); heart muscle: 58.4362% (minimum 99%, Missing); hippocampal formation: 57.2581% (minimum 99%, Missing); hypothalamus: 68.5990% (minimum 99%, Missing); kidney: 47.4916% (minimum 99%, Missing); liver: 46.5574% (minimum 99%, Missing); lung: 57.2581% (minimum 99%, Missing); lymph node: 42.6426% (minimum 97%, Missing); midbrain: 70.6468% (minimum 99%, Missing); pancreas: 54.1985% (minimum 99%, Missing); parathyroid gland: 51.2635% (minimum 97%, Missing); pituitary gland: 60.6838% (minimum 99%, Missing); rectum: 54.8263% (minimum 97%, Missing); retina: 49.8246% (minimum 99%, Missing); salivary gland: 57.0281% (minimum 97%, Missing); skeletal muscle: 55.9055% (minimum 99%, Missing); skin: 57.9592% (minimum 95%, Missing); small intestine: 57.0281% (minimum 99%, Missing); smooth muscle: 59.1667% (minimum 99%, Missing); spinal cord: 67.6190% (minimum 99%, Missing); spleen: 47.6510% (minimum 95%, Missing); stomach: 56.1265% (minimum 97%, Missing); thymus: 43.9628% (minimum 95%, Missing); thyroid gland: 47.9730% (minimum 95%, Missing); tongue: 56.1265% (minimum 97%, Missing); urinary bladder: 53.7879% (minimum 97%, Missing)",-0.510372,-0.543574,-0.716397,0,80,unavailable,37.7,19.1,18.1,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 2); thymus: 18.1 nTPM (manageable, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.4 nTPM (manageable, limit 5); retina: 14.3 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 2); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 2); skeletal muscle: 11.2 nTPM (vital, limit 1); stomach: 11.1 nTPM (protected, limit 2); tongue: 11.1 nTPM (protected, limit 2); salivary gland: 10.7 nTPM (protected, limit 2); small intestine: 10.7 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); lung: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 2); skin: 10.3 nTPM (manageable, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168438,CDC40,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.0281% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 65.4378% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); bone marrow: 27.3603% (minimum 75%, Missing); cerebellum: 62.2807% (minimum 75%, Missing); cerebral cortex: 52.3985% (minimum 75%, Missing); choroid plexus: 68.2692% (minimum 75%, Missing); colon: 57.0281% (minimum 70%, Missing); duodenum: 57.0281% (minimum 75%, Missing); esophagus: 57.7236% (minimum 70%, Missing); heart muscle: 58.4362% (minimum 75%, Missing); hippocampal formation: 57.2581% (minimum 75%, Missing); hypothalamus: 68.5990% (minimum 75%, Missing); kidney: 47.4916% (minimum 75%, Missing); liver: 46.5574% (minimum 75%, Missing); lung: 57.2581% (minimum 75%, Missing); lymph node: 42.6426% (minimum 70%, Missing); midbrain: 70.6468% (minimum 75%, Missing); pancreas: 54.1985% (minimum 75%, Missing); parathyroid gland: 51.2635% (minimum 70%, Missing); pituitary gland: 60.6838% (minimum 75%, Missing); rectum: 54.8263% (minimum 70%, Missing); retina: 49.8246% (minimum 75%, Missing); salivary gland: 57.0281% (minimum 70%, Missing); skeletal muscle: 55.9055% (minimum 75%, Missing); skin: 57.9592% (minimum 65%, Missing); small intestine: 57.0281% (minimum 75%, Missing); smooth muscle: 59.1667% (minimum 75%, Missing); spinal cord: 67.6190% (minimum 75%, Missing); spleen: 47.6510% (minimum 65%, Missing); stomach: 56.1265% (minimum 70%, Missing); thymus: 43.9628% (minimum 65%, Missing); thyroid gland: 47.9730% (minimum 65%, Missing); tongue: 56.1265% (minimum 70%, Missing); urinary bladder: 53.7879% (minimum 70%, Missing)",-0.210372,-0.273574,-0.476397,0,80,unavailable,37.7,19.1,18.1,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 2); thymus: 18.1 nTPM (manageable, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.4 nTPM (manageable, limit 5); retina: 14.3 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 2); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 2); skeletal muscle: 11.2 nTPM (vital, limit 1); stomach: 11.1 nTPM (protected, limit 2); tongue: 11.1 nTPM (protected, limit 2); salivary gland: 10.7 nTPM (protected, limit 2); small intestine: 10.7 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); lung: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 2); skin: 10.3 nTPM (manageable, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168438,CDC40,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.0281% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 65.4378% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); bone marrow: 27.3603% (minimum 75%, Missing); cerebellum: 62.2807% (minimum 75%, Missing); cerebral cortex: 52.3985% (minimum 75%, Missing); choroid plexus: 68.2692% (minimum 75%, Missing); colon: 57.0281% (minimum 70%, Missing); duodenum: 57.0281% (minimum 75%, Missing); esophagus: 57.7236% (minimum 70%, Missing); heart muscle: 58.4362% (minimum 75%, Missing); hippocampal formation: 57.2581% (minimum 75%, Missing); hypothalamus: 68.5990% (minimum 75%, Missing); kidney: 47.4916% (minimum 75%, Missing); liver: 46.5574% (minimum 75%, Missing); lung: 57.2581% (minimum 75%, Missing); lymph node: 42.6426% (minimum 70%, Missing); midbrain: 70.6468% (minimum 75%, Missing); pancreas: 54.1985% (minimum 75%, Missing); parathyroid gland: 51.2635% (minimum 70%, Missing); pituitary gland: 60.6838% (minimum 75%, Missing); rectum: 54.8263% (minimum 70%, Missing); retina: 49.8246% (minimum 75%, Missing); salivary gland: 57.0281% (minimum 70%, Missing); skeletal muscle: 55.9055% (minimum 75%, Missing); skin: 57.9592% (minimum 65%, Missing); small intestine: 57.0281% (minimum 75%, Missing); smooth muscle: 59.1667% (minimum 75%, Missing); spinal cord: 67.6190% (minimum 75%, Missing); spleen: 47.6510% (minimum 65%, Missing); stomach: 56.1265% (minimum 70%, Missing); thymus: 43.9628% (minimum 65%, Missing); thyroid gland: 47.9730% (minimum 65%, Missing); tongue: 56.1265% (minimum 70%, Missing); urinary bladder: 53.7879% (minimum 70%, Missing)",-0.210372,-0.273574,-0.476397,0,80,unavailable,37.7,19.1,18.1,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 3); thymus: 18.1 nTPM (manageable, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.4 nTPM (manageable, limit 5); retina: 14.3 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 3); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 3); skeletal muscle: 11.2 nTPM (vital, limit 1); stomach: 11.1 nTPM (protected, limit 3); tongue: 11.1 nTPM (protected, limit 3); salivary gland: 10.7 nTPM (protected, limit 3); small intestine: 10.7 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); lung: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 3); skin: 10.3 nTPM (manageable, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168438,CDC40,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.0281% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 65.4378% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); bone marrow: 27.3603% (minimum 75%, Missing); cerebellum: 62.2807% (minimum 75%, Missing); cerebral cortex: 52.3985% (minimum 75%, Missing); choroid plexus: 68.2692% (minimum 75%, Missing); colon: 57.0281% (minimum 70%, Missing); duodenum: 57.0281% (minimum 75%, Missing); esophagus: 57.7236% (minimum 70%, Missing); heart muscle: 58.4362% (minimum 75%, Missing); hippocampal formation: 57.2581% (minimum 75%, Missing); hypothalamus: 68.5990% (minimum 75%, Missing); kidney: 47.4916% (minimum 75%, Missing); liver: 46.5574% (minimum 75%, Missing); lung: 57.2581% (minimum 75%, Missing); lymph node: 42.6426% (minimum 70%, Missing); midbrain: 70.6468% (minimum 75%, Missing); pancreas: 54.1985% (minimum 75%, Missing); parathyroid gland: 51.2635% (minimum 70%, Missing); pituitary gland: 60.6838% (minimum 75%, Missing); rectum: 54.8263% (minimum 70%, Missing); retina: 49.8246% (minimum 75%, Missing); salivary gland: 57.0281% (minimum 70%, Missing); skeletal muscle: 55.9055% (minimum 75%, Missing); skin: 57.9592% (minimum 65%, Missing); small intestine: 57.0281% (minimum 75%, Missing); smooth muscle: 59.1667% (minimum 75%, Missing); spinal cord: 67.6190% (minimum 75%, Missing); spleen: 47.6510% (minimum 65%, Missing); stomach: 56.1265% (minimum 70%, Missing); thymus: 43.9628% (minimum 65%, Missing); thyroid gland: 47.9730% (minimum 65%, Missing); tongue: 56.1265% (minimum 70%, Missing); urinary bladder: 53.7879% (minimum 70%, Missing)",-0.210372,-0.273574,-0.476397,0,80,unavailable,37.7,19.1,18.1,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 3); thymus: 18.1 nTPM (manageable, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.4 nTPM (manageable, limit 5); retina: 14.3 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 3); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 3); skeletal muscle: 11.2 nTPM (vital, limit 1); stomach: 11.1 nTPM (protected, limit 3); tongue: 11.1 nTPM (protected, limit 3); salivary gland: 10.7 nTPM (protected, limit 3); small intestine: 10.7 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); lung: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 3); skin: 10.3 nTPM (manageable, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168438,CDC40,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.0281% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.4378% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 50.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 27.3603% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.2807% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 52.3985% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.2692% (minimum 75%, Baseline (adaptation disabled)); colon: 57.0281% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.0281% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.7236% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.4362% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.2581% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.5990% (minimum 75%, Baseline (adaptation disabled)); kidney: 47.4916% (minimum 75%, Baseline (adaptation disabled)); liver: 46.5574% (minimum 75%, Baseline (adaptation disabled)); lung: 57.2581% (minimum 75%, Baseline (adaptation disabled)); lymph node: 42.6426% (minimum 70%, Baseline (adaptation disabled)); midbrain: 70.6468% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.1985% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.2635% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 60.6838% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.8263% (minimum 70%, Baseline (adaptation disabled)); retina: 49.8246% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 57.0281% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.9055% (minimum 75%, Baseline (adaptation disabled)); skin: 57.9592% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.0281% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.1667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.6190% (minimum 75%, Baseline (adaptation disabled)); spleen: 47.6510% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.1265% (minimum 70%, Baseline (adaptation disabled)); thymus: 43.9628% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 47.9730% (minimum 65%, Baseline (adaptation disabled)); tongue: 56.1265% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 53.7879% (minimum 70%, Baseline (adaptation disabled))",-0.210372,-0.273574,-0.476397,0,80,unavailable,37.7,19.1,18.1,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 3); thymus: 18.1 nTPM (manageable, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.4 nTPM (manageable, limit 5); retina: 14.3 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 3); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 3); skeletal muscle: 11.2 nTPM (vital, limit 1); stomach: 11.1 nTPM (protected, limit 3); tongue: 11.1 nTPM (protected, limit 3); salivary gland: 10.7 nTPM (protected, limit 3); small intestine: 10.7 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); lung: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 3); skin: 10.3 nTPM (manageable, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168438,CDC40,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.028995,0.00899497,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168454,TXNDC2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.298995,0.248995,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168454,TXNDC2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.298995,0.248995,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168454,TXNDC2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.298995,0.248995,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168454,TXNDC2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.348995,0.298995,0.246991,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168454,TXNDC2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.3789% (minimum 99%, Missing); cerebellum: 98.0808% (minimum 99%, Missing); cerebral cortex: 98.6789% (minimum 99%, Missing); choroid plexus: 98.6789% (minimum 99%, Missing); heart muscle: 98.8798% (minimum 99%, Missing); kidney: 97.5879% (minimum 99%, Missing); pancreas: 76.5773% (minimum 99%, Missing); pituitary gland: 97.1972% (minimum 99%, Missing); retina: 92.6527% (minimum 99%, Missing); salivary gland: 94.1804% (minimum 97%, Missing); skeletal muscle: 97.9818% (minimum 99%, Missing); smooth muscle: 98.6789% (minimum 99%, Missing); thyroid gland: 92.8298% (minimum 95%, Missing)",-0.0217017,-0.0281959,-0.224227,0,80,unavailable,29.7,6,7.5,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 2); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168491,CCDC110,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278298,0.241804,0.0157729,0,80,unavailable,29.7,6,7.5,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 2); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168491,CCDC110,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278298,0.241804,0.0157729,0,80,unavailable,29.7,6,7.5,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 3); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168491,CCDC110,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278298,0.241804,0.0157729,0,80,unavailable,29.7,6,7.5,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 3); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168491,CCDC110,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278298,0.241804,0.0157729,0,80,unavailable,29.7,6,7.5,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 3); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168491,CCDC110,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 92.3077% (minimum 97%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); salivary gland: 92.3077% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing)",-0.283333,-0.0469231,-0.0669231,0,80,unavailable,0.1,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168515,SCGB1D1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0166667,0.223077,0.173077,0,80,unavailable,0.1,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168515,SCGB1D1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0166667,0.223077,0.173077,0,80,unavailable,0.1,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168515,SCGB1D1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0166667,0.223077,0.173077,0,80,unavailable,0.1,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168515,SCGB1D1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0166667,0.223077,0.173077,0,80,unavailable,0.1,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168515,SCGB1D1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9247% (minimum 99%, Missing); amygdala: 96.1672% (minimum 99%, Missing); basal ganglia: 95.1314% (minimum 99%, Missing); cerebral cortex: 98.5274% (minimum 99%, Missing); choroid plexus: 79.6824% (minimum 99%, Missing); hippocampal formation: 95.0495% (minimum 99%, Missing); hypothalamus: 95.0904% (minimum 99%, Missing); kidney: 97.5265% (minimum 99%, Missing); lung: 97.3974% (minimum 99%, Missing); midbrain: 97.1831% (minimum 99%, Missing); pituitary gland: 98.1333% (minimum 99%, Missing); retina: 98.2206% (minimum 99%, Missing); spinal cord: 97.5265% (minimum 99%, Missing)",0.0357143,0.0104618,-0.193176,0,80,unavailable,56.3,4.4,3.2,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168589,DYNLRB2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335714,0.280462,0.0468243,0,80,unavailable,56.3,4.4,3.2,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168589,DYNLRB2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335714,0.280462,0.0468243,0,80,unavailable,56.3,4.4,3.2,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168589,DYNLRB2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335714,0.280462,0.0468243,0,80,unavailable,56.3,4.4,3.2,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168589,DYNLRB2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335714,0.280462,0.0468243,0,80,unavailable,56.3,4.4,3.2,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168589,DYNLRB2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
True,compatible,,True,True,True,,0.05,0.0275,0.00501247,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168594,ADAM29,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.2975,0.245012,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168594,ADAM29,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.2975,0.245012,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168594,ADAM29,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.2975,0.245012,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168594,ADAM29,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.2975,0.245012,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168594,ADAM29,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 98.8889% (minimum 99%, Missing)",0.05,0.03,-0.00111111,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168619,ADAM18,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.238889,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168619,ADAM18,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.238889,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168619,ADAM18,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.238889,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168619,ADAM18,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.238889,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168619,ADAM18,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"amygdala: 97.6589% (minimum 99%, Missing); basal ganglia: 95.7377% (minimum 99%, Missing); choroid plexus: 76.2402% (minimum 99%, Missing); hippocampal formation: 96.3696% (minimum 99%, Missing); hypothalamus: 96.3696% (minimum 99%, Missing); lung: 92.4051% (minimum 98%, Approved)",0.0265886,0.026587,-0.227598,0,5,partial,9.1,0.1,0.7,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000168658,VWA3B,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.326589,0.296587,0.0124021,0,5,partial,9.1,0.1,0.7,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000168658,VWA3B,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.326589,0.296587,0.0124021,0,5,partial,9.1,0.1,0.7,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000168658,VWA3B,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.326589,0.296587,0.0124021,0,5,partial,9.1,0.1,0.7,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000168658,VWA3B,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.326589,0.296587,0.0124021,0,5,partial,9.1,0.1,0.7,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000168658,VWA3B,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 97.2644% (minimum 99%, Missing); bone marrow: 90.6516% (minimum 99%, Missing); choroid plexus: 98.1595% (minimum 99%, Missing); skeletal muscle: 98.1595% (minimum 99%, Missing)",0.00238095,0.0115951,-0.0834844,0,80,unavailable,3.3,0.6,1.6,"bone marrow: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168676,KCTD19,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302381,0.281595,0.156516,0,80,unavailable,3.3,0.6,1.6,"bone marrow: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168676,KCTD19,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302381,0.281595,0.156516,0,80,unavailable,3.3,0.6,1.6,"bone marrow: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168676,KCTD19,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302381,0.281595,0.156516,0,80,unavailable,3.3,0.6,1.6,"bone marrow: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168676,KCTD19,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302381,0.281595,0.156516,0,80,unavailable,3.3,0.6,1.6,"bone marrow: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168676,KCTD19,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 42.3077% (minimum 95%, Missing); adrenal gland: 62.8571% (minimum 99%, Missing); amygdala: 20.7547% (minimum 99%, Missing); basal ganglia: 21.5686% (minimum 99%, Missing); cerebellum: 28.9474% (minimum 99%, Missing); cerebral cortex: 18.4874% (minimum 99%, Missing); choroid plexus: 68.7500% (minimum 99%, Missing); colon: 88.0000% (minimum 95%, Approved); heart muscle: 88.0000% (minimum 98%, Approved); hippocampal formation: 24.7191% (minimum 99%, Missing); hypothalamus: 25.0000% (minimum 99%, Missing); kidney: 84.6154% (minimum 98%, Approved); liver: 95.6522% (minimum 98%, Approved); lung: 95.6522% (minimum 98%, Approved); midbrain: 22.2222% (minimum 99%, Missing); pancreas: 95.6522% (minimum 98%, Approved); pituitary gland: 53.6585% (minimum 99%, Missing); retina: 46.8085% (minimum 99%, Missing); salivary gland: 78.5714% (minimum 95%, Approved); skeletal muscle: 33.8462% (minimum 99%, Missing); skin: 84.6154% (minimum 90%, Approved); small intestine: 95.6522% (minimum 98%, Approved); spinal cord: 31.8841% (minimum 99%, Missing); stomach: 84.6154% (minimum 95%, Approved); thymus: 91.6667% (minimum 95%, Missing); thyroid gland: 28.5714% (minimum 95%, Missing); tongue: 39.2857% (minimum 97%, Missing)",-0.664286,-0.577143,-0.805126,0,1,partial,9.7,3.4,5.5,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168702,LRP1B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 42.3077% (minimum 65%, Missing); adrenal gland: 62.8571% (minimum 75%, Missing); amygdala: 20.7547% (minimum 75%, Missing); basal ganglia: 21.5686% (minimum 75%, Missing); cerebellum: 28.9474% (minimum 75%, Missing); cerebral cortex: 18.4874% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); hippocampal formation: 24.7191% (minimum 75%, Missing); hypothalamus: 25.0000% (minimum 75%, Missing); midbrain: 22.2222% (minimum 75%, Missing); pituitary gland: 53.6585% (minimum 75%, Missing); retina: 46.8085% (minimum 75%, Missing); skeletal muscle: 33.8462% (minimum 75%, Missing); spinal cord: 31.8841% (minimum 75%, Missing); thyroid gland: 28.5714% (minimum 65%, Missing); tongue: 39.2857% (minimum 70%, Missing)",-0.364286,-0.307143,-0.565126,0,1,partial,9.7,3.4,5.5,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168702,LRP1B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 42.3077% (minimum 65%, Missing); adrenal gland: 62.8571% (minimum 75%, Missing); amygdala: 20.7547% (minimum 75%, Missing); basal ganglia: 21.5686% (minimum 75%, Missing); cerebellum: 28.9474% (minimum 75%, Missing); cerebral cortex: 18.4874% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); hippocampal formation: 24.7191% (minimum 75%, Missing); hypothalamus: 25.0000% (minimum 75%, Missing); midbrain: 22.2222% (minimum 75%, Missing); pituitary gland: 53.6585% (minimum 75%, Missing); retina: 46.8085% (minimum 75%, Missing); skeletal muscle: 33.8462% (minimum 75%, Missing); spinal cord: 31.8841% (minimum 75%, Missing); thyroid gland: 28.5714% (minimum 65%, Missing); tongue: 39.2857% (minimum 70%, Missing)",-0.364286,-0.307143,-0.565126,0,1,partial,9.7,3.4,5.5,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168702,LRP1B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 42.3077% (minimum 65%, Missing); adrenal gland: 62.8571% (minimum 75%, Missing); amygdala: 20.7547% (minimum 75%, Missing); basal ganglia: 21.5686% (minimum 75%, Missing); cerebellum: 28.9474% (minimum 75%, Missing); cerebral cortex: 18.4874% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); hippocampal formation: 24.7191% (minimum 75%, Missing); hypothalamus: 25.0000% (minimum 75%, Missing); midbrain: 22.2222% (minimum 75%, Missing); pituitary gland: 53.6585% (minimum 75%, Missing); retina: 46.8085% (minimum 75%, Missing); skeletal muscle: 33.8462% (minimum 75%, Missing); spinal cord: 31.8841% (minimum 75%, Missing); thyroid gland: 28.5714% (minimum 65%, Missing); tongue: 39.2857% (minimum 70%, Missing)",-0.364286,-0.307143,-0.565126,0,1,partial,9.7,3.4,5.5,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168702,LRP1B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 42.3077% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.8571% (minimum 75%, Baseline (adaptation disabled)); amygdala: 20.7547% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 21.5686% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 28.9474% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 18.4874% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.7500% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 24.7191% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 25.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 22.2222% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 53.6585% (minimum 75%, Baseline (adaptation disabled)); retina: 46.8085% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 33.8462% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 31.8841% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 28.5714% (minimum 65%, Baseline (adaptation disabled)); tongue: 39.2857% (minimum 70%, Baseline (adaptation disabled))",-0.364286,-0.307143,-0.565126,0,1,partial,9.7,3.4,5.5,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168702,LRP1B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168757,TSPY2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168757,TSPY2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168757,TSPY2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168757,TSPY2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168757,TSPY2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.9661% (minimum 95%, Missing); adrenal gland: 78.4091% (minimum 99%, Missing); amygdala: 87.0662% (minimum 99%, Missing); basal ganglia: 87.8981% (minimum 99%, Missing); bone marrow: 76.4543% (minimum 99%, Missing); cerebellum: 83.3837% (minimum 99%, Missing); cerebral cortex: 85.4489% (minimum 99%, Missing); choroid plexus: 70.2290% (minimum 99%, Missing); colon: 78.1870% (minimum 97%, Missing); duodenum: 62.7273% (minimum 99%, Missing); esophagus: 74.7967% (minimum 97%, Missing); heart muscle: 74.5946% (minimum 99%, Missing); hippocampal formation: 87.0662% (minimum 99%, Missing); hypothalamus: 86.5204% (minimum 99%, Missing); kidney: 59.6112% (minimum 99%, Missing); liver: 37.7049% (minimum 99%, Missing); lung: 84.4037% (minimum 99%, Missing); lymph node: 80.4665% (minimum 97%, Missing); midbrain: 86.7925% (minimum 99%, Missing); pancreas: 59.3548% (minimum 99%, Missing); parathyroid gland: 75.2044% (minimum 97%, Missing); pituitary gland: 87.3418% (minimum 99%, Missing); rectum: 74.5946% (minimum 97%, Missing); retina: 80.7018% (minimum 99%, Missing); salivary gland: 82.1429% (minimum 97%, Missing); skeletal muscle: 60.9272% (minimum 99%, Missing); skin: 73.2095% (minimum 95%, Missing); small intestine: 63.3028% (minimum 99%, Missing); smooth muscle: 78.4091% (minimum 99%, Missing); spinal cord: 85.1852% (minimum 99%, Missing); spleen: 85.1852% (minimum 95%, Missing); stomach: 77.7465% (minimum 97%, Missing); thymus: 55.6452% (minimum 95%, Missing); thyroid gland: 81.1765% (minimum 95%, Missing); tongue: 61.0619% (minimum 97%, Missing); urinary bladder: 81.4159% (minimum 97%, Missing)",-0.393548,-0.359381,-0.612951,0,4,partial,45.6,17.6,22,"liver: 45.6 nTPM (vital, limit 1); thymus: 22 nTPM (manageable, limit 5); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 2); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); skin: 10.1 nTPM (manageable, limit 5); rectum: 9.4 nTPM (protected, limit 2); heart muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 2); parathyroid gland: 9.1 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); colon: 7.7 nTPM (protected, limit 2); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 2); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); urinary bladder: 6.3 nTPM (protected, limit 2); salivary gland: 6 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168904,LRRC28,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 70.2290% (minimum 75%, Missing); duodenum: 62.7273% (minimum 75%, Missing); heart muscle: 74.5946% (minimum 75%, Missing); kidney: 59.6112% (minimum 75%, Missing); liver: 37.7049% (minimum 75%, Missing); pancreas: 59.3548% (minimum 75%, Missing); skeletal muscle: 60.9272% (minimum 75%, Missing); small intestine: 63.3028% (minimum 75%, Missing); thymus: 55.6452% (minimum 65%, Missing); tongue: 61.0619% (minimum 70%, Missing)",-0.0935484,-0.0893805,-0.372951,0,4,partial,45.6,17.6,22,"liver: 45.6 nTPM (vital, limit 1); thymus: 22 nTPM (manageable, limit 5); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 2); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); skin: 10.1 nTPM (manageable, limit 5); rectum: 9.4 nTPM (protected, limit 2); heart muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 2); parathyroid gland: 9.1 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); colon: 7.7 nTPM (protected, limit 2); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 2); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); urinary bladder: 6.3 nTPM (protected, limit 2); salivary gland: 6 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168904,LRRC28,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 70.2290% (minimum 75%, Missing); duodenum: 62.7273% (minimum 75%, Missing); heart muscle: 74.5946% (minimum 75%, Missing); kidney: 59.6112% (minimum 75%, Missing); liver: 37.7049% (minimum 75%, Missing); pancreas: 59.3548% (minimum 75%, Missing); skeletal muscle: 60.9272% (minimum 75%, Missing); small intestine: 63.3028% (minimum 75%, Missing); thymus: 55.6452% (minimum 65%, Missing); tongue: 61.0619% (minimum 70%, Missing)",-0.0935484,-0.0893805,-0.372951,0,4,partial,45.6,17.6,22,"liver: 45.6 nTPM (vital, limit 1); thymus: 22 nTPM (manageable, limit 5); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 3); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); skin: 10.1 nTPM (manageable, limit 5); rectum: 9.4 nTPM (protected, limit 3); heart muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 3); parathyroid gland: 9.1 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 3); adipose tissue: 7.8 nTPM (manageable, limit 5); colon: 7.7 nTPM (protected, limit 3); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 3); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); urinary bladder: 6.3 nTPM (protected, limit 3); salivary gland: 6 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168904,LRRC28,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 70.2290% (minimum 75%, Missing); duodenum: 62.7273% (minimum 75%, Missing); heart muscle: 74.5946% (minimum 75%, Missing); kidney: 59.6112% (minimum 75%, Missing); liver: 37.7049% (minimum 75%, Missing); pancreas: 59.3548% (minimum 75%, Missing); skeletal muscle: 60.9272% (minimum 75%, Missing); small intestine: 63.3028% (minimum 75%, Missing); thymus: 55.6452% (minimum 65%, Missing); tongue: 61.0619% (minimum 70%, Missing)",-0.0935484,-0.0893805,-0.372951,0,4,partial,45.6,17.6,22,"liver: 45.6 nTPM (vital, limit 1); thymus: 22 nTPM (manageable, limit 5); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 3); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); skin: 10.1 nTPM (manageable, limit 5); rectum: 9.4 nTPM (protected, limit 3); heart muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 3); parathyroid gland: 9.1 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 3); adipose tissue: 7.8 nTPM (manageable, limit 5); colon: 7.7 nTPM (protected, limit 3); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 3); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); urinary bladder: 6.3 nTPM (protected, limit 3); salivary gland: 6 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168904,LRRC28,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 70.2290% (minimum 75%, Baseline (adaptation disabled)); duodenum: 62.7273% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 74.5946% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.6112% (minimum 75%, Baseline (adaptation disabled)); liver: 37.7049% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.3548% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 60.9272% (minimum 75%, Baseline (adaptation disabled)); small intestine: 63.3028% (minimum 75%, Baseline (adaptation disabled)); thymus: 55.6452% (minimum 65%, Baseline (adaptation disabled)); tongue: 61.0619% (minimum 70%, Baseline (adaptation disabled))",-0.0935484,-0.0893805,-0.372951,0,4,partial,45.6,17.6,22,"liver: 45.6 nTPM (vital, limit 1); thymus: 22 nTPM (manageable, limit 5); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 3); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); skin: 10.1 nTPM (manageable, limit 5); rectum: 9.4 nTPM (protected, limit 3); heart muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 3); parathyroid gland: 9.1 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 3); adipose tissue: 7.8 nTPM (manageable, limit 5); colon: 7.7 nTPM (protected, limit 3); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 3); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); urinary bladder: 6.3 nTPM (protected, limit 3); salivary gland: 6 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168904,LRRC28,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168930,TRIM49,admission_only,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168930,TRIM49,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168930,TRIM49,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168930,TRIM49,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168930,TRIM49,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6168% (minimum 95%, Missing); adrenal gland: 66.3366% (minimum 99%, Missing); amygdala: 74.8603% (minimum 99%, Missing); basal ganglia: 73.2240% (minimum 99%, Missing); bone marrow: 82.2086% (minimum 99%, Missing); cerebellum: 54.4715% (minimum 99%, Missing); cerebral cortex: 76.1364% (minimum 99%, Missing); choroid plexus: 89.3333% (minimum 99%, Missing); colon: 66.0099% (minimum 97%, Missing); duodenum: 74.0331% (minimum 99%, Missing); esophagus: 75.7062% (minimum 97%, Missing); heart muscle: 69.0722% (minimum 99%, Missing); hippocampal formation: 72.0430% (minimum 99%, Missing); hypothalamus: 68.7179% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 63.5071% (minimum 99%, Missing); lung: 65.3659% (minimum 99%, Missing); lymph node: 59.5556% (minimum 97%, Missing); midbrain: 72.0430% (minimum 99%, Missing); pancreas: 68.7179% (minimum 99%, Missing); parathyroid gland: 64.7343% (minimum 97%, Missing); pituitary gland: 67.6768% (minimum 99%, Missing); rectum: 72.8261% (minimum 97%, Missing); retina: 54.4715% (minimum 99%, Missing); salivary gland: 72.8261% (minimum 97%, Missing); skeletal muscle: 76.1364% (minimum 99%, Missing); skin: 77.0115% (minimum 95%, Missing); small intestine: 65.3659% (minimum 99%, Missing); smooth muscle: 63.5071% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 60.3604% (minimum 95%, Missing); stomach: 73.2240% (minimum 97%, Missing); thymus: 49.6296% (minimum 95%, Missing); thyroid gland: 62.6168% (minimum 95%, Missing); tongue: 69.4301% (minimum 97%, Missing); urinary bladder: 67.6768% (minimum 97%, Missing)",-0.453704,-0.374444,-0.445285,0,80,unavailable,11.2,9.1,13.6,"thymus: 13.6 nTPM (manageable, limit 5); retina: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 2); spleen: 8.8 nTPM (manageable, limit 5); thyroid gland: 8 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 2); pancreas: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 2); midbrain: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); rectum: 5 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 2); cerebral cortex: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168944,CEP120,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6168% (minimum 65%, Missing); adrenal gland: 66.3366% (minimum 75%, Missing); amygdala: 74.8603% (minimum 75%, Missing); basal ganglia: 73.2240% (minimum 75%, Missing); cerebellum: 54.4715% (minimum 75%, Missing); colon: 66.0099% (minimum 70%, Missing); duodenum: 74.0331% (minimum 75%, Missing); heart muscle: 69.0722% (minimum 75%, Missing); hippocampal formation: 72.0430% (minimum 75%, Missing); hypothalamus: 68.7179% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 63.5071% (minimum 75%, Missing); lung: 65.3659% (minimum 75%, Missing); lymph node: 59.5556% (minimum 70%, Missing); midbrain: 72.0430% (minimum 75%, Missing); pancreas: 68.7179% (minimum 75%, Missing); parathyroid gland: 64.7343% (minimum 70%, Missing); pituitary gland: 67.6768% (minimum 75%, Missing); retina: 54.4715% (minimum 75%, Missing); small intestine: 65.3659% (minimum 75%, Missing); smooth muscle: 63.5071% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 60.3604% (minimum 65%, Missing); thymus: 49.6296% (minimum 65%, Missing); thyroid gland: 62.6168% (minimum 65%, Missing); tongue: 69.4301% (minimum 70%, Missing); urinary bladder: 67.6768% (minimum 70%, Missing)",-0.153704,-0.104444,-0.205285,0,80,unavailable,11.2,9.1,13.6,"thymus: 13.6 nTPM (manageable, limit 5); retina: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 2); spleen: 8.8 nTPM (manageable, limit 5); thyroid gland: 8 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 2); pancreas: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 2); midbrain: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); rectum: 5 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 2); cerebral cortex: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168944,CEP120,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6168% (minimum 65%, Missing); adrenal gland: 66.3366% (minimum 75%, Missing); amygdala: 74.8603% (minimum 75%, Missing); basal ganglia: 73.2240% (minimum 75%, Missing); cerebellum: 54.4715% (minimum 75%, Missing); colon: 66.0099% (minimum 70%, Missing); duodenum: 74.0331% (minimum 75%, Missing); heart muscle: 69.0722% (minimum 75%, Missing); hippocampal formation: 72.0430% (minimum 75%, Missing); hypothalamus: 68.7179% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 63.5071% (minimum 75%, Missing); lung: 65.3659% (minimum 75%, Missing); lymph node: 59.5556% (minimum 70%, Missing); midbrain: 72.0430% (minimum 75%, Missing); pancreas: 68.7179% (minimum 75%, Missing); parathyroid gland: 64.7343% (minimum 70%, Missing); pituitary gland: 67.6768% (minimum 75%, Missing); retina: 54.4715% (minimum 75%, Missing); small intestine: 65.3659% (minimum 75%, Missing); smooth muscle: 63.5071% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 60.3604% (minimum 65%, Missing); thymus: 49.6296% (minimum 65%, Missing); thyroid gland: 62.6168% (minimum 65%, Missing); tongue: 69.4301% (minimum 70%, Missing); urinary bladder: 67.6768% (minimum 70%, Missing)",-0.153704,-0.104444,-0.205285,0,80,unavailable,11.2,9.1,13.6,"thymus: 13.6 nTPM (manageable, limit 5); retina: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 3); spleen: 8.8 nTPM (manageable, limit 5); thyroid gland: 8 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 3); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 3); pancreas: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 3); midbrain: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); rectum: 5 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 3); cerebral cortex: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168944,CEP120,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6168% (minimum 65%, Missing); adrenal gland: 66.3366% (minimum 75%, Missing); amygdala: 74.8603% (minimum 75%, Missing); basal ganglia: 73.2240% (minimum 75%, Missing); cerebellum: 54.4715% (minimum 75%, Missing); colon: 66.0099% (minimum 70%, Missing); duodenum: 74.0331% (minimum 75%, Missing); heart muscle: 69.0722% (minimum 75%, Missing); hippocampal formation: 72.0430% (minimum 75%, Missing); hypothalamus: 68.7179% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 63.5071% (minimum 75%, Missing); lung: 65.3659% (minimum 75%, Missing); lymph node: 59.5556% (minimum 70%, Missing); midbrain: 72.0430% (minimum 75%, Missing); pancreas: 68.7179% (minimum 75%, Missing); parathyroid gland: 64.7343% (minimum 70%, Missing); pituitary gland: 67.6768% (minimum 75%, Missing); retina: 54.4715% (minimum 75%, Missing); small intestine: 65.3659% (minimum 75%, Missing); smooth muscle: 63.5071% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 60.3604% (minimum 65%, Missing); thymus: 49.6296% (minimum 65%, Missing); thyroid gland: 62.6168% (minimum 65%, Missing); tongue: 69.4301% (minimum 70%, Missing); urinary bladder: 67.6768% (minimum 70%, Missing)",-0.153704,-0.104444,-0.205285,0,80,unavailable,11.2,9.1,13.6,"thymus: 13.6 nTPM (manageable, limit 5); retina: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 3); spleen: 8.8 nTPM (manageable, limit 5); thyroid gland: 8 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 3); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 3); pancreas: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 3); midbrain: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); rectum: 5 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 3); cerebral cortex: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168944,CEP120,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6168% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 66.3366% (minimum 75%, Baseline (adaptation disabled)); amygdala: 74.8603% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.2240% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.4715% (minimum 75%, Baseline (adaptation disabled)); colon: 66.0099% (minimum 70%, Baseline (adaptation disabled)); duodenum: 74.0331% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 69.0722% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.0430% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.7179% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 63.5071% (minimum 75%, Baseline (adaptation disabled)); lung: 65.3659% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.5556% (minimum 70%, Baseline (adaptation disabled)); midbrain: 72.0430% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.7179% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.7343% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.6768% (minimum 75%, Baseline (adaptation disabled)); retina: 54.4715% (minimum 75%, Baseline (adaptation disabled)); small intestine: 65.3659% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.5071% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.3604% (minimum 65%, Baseline (adaptation disabled)); thymus: 49.6296% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.6168% (minimum 65%, Baseline (adaptation disabled)); tongue: 69.4301% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.6768% (minimum 70%, Baseline (adaptation disabled))",-0.153704,-0.104444,-0.205285,0,80,unavailable,11.2,9.1,13.6,"thymus: 13.6 nTPM (manageable, limit 5); retina: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 3); spleen: 8.8 nTPM (manageable, limit 5); thyroid gland: 8 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 3); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 3); pancreas: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 3); midbrain: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); rectum: 5 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 3); cerebral cortex: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000168944,CEP120,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.00255121,0,1,partial,0.4,0.1,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169059,VCX3A,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242551,0,1,partial,0.4,0.1,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169059,VCX3A,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242551,0,1,partial,0.4,0.1,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169059,VCX3A,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242551,0,1,partial,0.4,0.1,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169059,VCX3A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346262,0.298127,0.242551,0,1,partial,0.4,0.1,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169059,VCX3A,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.4088% (minimum 99%, Missing); basal ganglia: 93.5657% (minimum 99%, Missing); cerebral cortex: 92.5729% (minimum 95%, Enhanced); choroid plexus: 72.4066% (minimum 99%, Missing); hippocampal formation: 93.8172% (minimum 99%, Missing); hypothalamus: 92.5729% (minimum 99%, Missing); lung: 91.1227% (minimum 95%, Enhanced); pituitary gland: 94.5799% (minimum 99%, Missing); spinal cord: 98.8669% (minimum 99%, Missing)",0.0471429,0.03,-0.265934,0,4,partial,13.3,0.2,0.1,"choroid plexus: 13.3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169064,ZBBX,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 72.4066% (minimum 75%, Missing)",0.347143,0.3,-0.0259336,0,4,partial,13.3,0.2,0.1,"choroid plexus: 13.3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169064,ZBBX,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 72.4066% (minimum 75%, Missing)",0.347143,0.3,-0.0259336,0,4,partial,13.3,0.2,0.1,"choroid plexus: 13.3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169064,ZBBX,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 72.4066% (minimum 75%, Missing)",0.347143,0.3,-0.0259336,0,4,partial,13.3,0.2,0.1,"choroid plexus: 13.3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169064,ZBBX,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 72.4066% (minimum 75%, Baseline (adaptation disabled))",0.347143,0.294302,-0.0259336,0,4,partial,13.3,0.2,0.1,"choroid plexus: 13.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169064,ZBBX,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.5037% (minimum 99%, Missing); basal ganglia: 97.5309% (minimum 99%, Missing); choroid plexus: 83.5095% (minimum 99%, Missing); hippocampal formation: 97.5309% (minimum 99%, Missing); hypothalamus: 97.2906% (minimum 99%, Missing); lung: 94.0476% (minimum 95%, Enhanced); pituitary gland: 92.7230% (minimum 99%, Missing)",0.0375,0.0224623,-0.154905,0,3,partial,7.8,1,0.5,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169126,ODAD2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.3375,0.292462,0.0850951,0,3,partial,7.8,1,0.5,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169126,ODAD2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.3375,0.292462,0.0850951,0,3,partial,7.8,1,0.5,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169126,ODAD2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.3375,0.292462,0.0850951,0,3,partial,7.8,1,0.5,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169126,ODAD2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.3375,0.275309,0.0850951,0,3,partial,7.8,1,0.5,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169126,ODAD2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.0227536,0.01,0,80,unavailable,0,0.1,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169154,GOT1L1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.292754,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169154,GOT1L1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.292754,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169154,GOT1L1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.292754,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169154,GOT1L1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.292754,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169154,GOT1L1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 70.2703% (minimum 90%, Approved); adrenal gland: 60.0000% (minimum 98%, Approved); amygdala: 30.1158% (minimum 99%, Missing); basal ganglia: 24.8408% (minimum 99%, Missing); cerebellum: 22.5434% (minimum 99%, Missing); cerebral cortex: 23.6364% (minimum 99%, Missing); choroid plexus: 21.4876% (minimum 99%, Missing); colon: 75.7282% (minimum 95%, Approved); duodenum: 85.7143% (minimum 98%, Approved); esophagus: 88.6364% (minimum 95%, Approved); heart muscle: 67.8261% (minimum 98%, Approved); hippocampal formation: 27.3684% (minimum 99%, Missing); hypothalamus: 27.6596% (minimum 99%, Missing); kidney: 82.9787% (minimum 99%, Missing); liver: 90.6977% (minimum 98%, Approved); lung: 79.5918% (minimum 98%, Approved); lymph node: 85.7143% (minimum 95%, Approved); midbrain: 39.1960% (minimum 99%, Missing); pancreas: 85.7143% (minimum 98%, Approved); parathyroid gland: 84.7826% (minimum 95%, Approved); pituitary gland: 22.0339% (minimum 99%, Missing); rectum: 92.8571% (minimum 95%, Approved); retina: 39.1960% (minimum 99%, Missing); salivary gland: 89.6552% (minimum 97%, Missing); skeletal muscle: 91.7647% (minimum 98%, Approved); skin: 88.6364% (minimum 90%, Approved); small intestine: 81.2500% (minimum 98%, Approved); smooth muscle: 63.9344% (minimum 99%, Missing); spinal cord: 40.0000% (minimum 99%, Missing); spleen: 61.9048% (minimum 90%, Approved); stomach: 83.8710% (minimum 97%, Missing); thyroid gland: 77.2277% (minimum 90%, Approved); urinary bladder: 75.0000% (minimum 95%, Approved)",-0.280952,-0.2,-0.775124,0,2,partial,28.5,2.6,4.8,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 2); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 2); kidney: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); salivary gland / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169169,CPT1C,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.0000% (minimum 70%, Approved); amygdala: 30.1158% (minimum 75%, Missing); basal ganglia: 24.8408% (minimum 75%, Missing); cerebellum: 22.5434% (minimum 75%, Missing); cerebral cortex: 23.6364% (minimum 75%, Missing); choroid plexus: 21.4876% (minimum 75%, Missing); heart muscle: 67.8261% (minimum 70%, Approved); hippocampal formation: 27.3684% (minimum 75%, Missing); hypothalamus: 27.6596% (minimum 75%, Missing); midbrain: 39.1960% (minimum 75%, Missing); pituitary gland: 22.0339% (minimum 75%, Missing); retina: 39.1960% (minimum 75%, Missing); smooth muscle: 63.9344% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing)",0.0190476,0.1,-0.535124,0,2,partial,28.5,2.6,4.8,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 2); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 2); kidney: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); salivary gland / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169169,CPT1C,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.0000% (minimum 70%, Approved); amygdala: 30.1158% (minimum 75%, Missing); basal ganglia: 24.8408% (minimum 75%, Missing); cerebellum: 22.5434% (minimum 75%, Missing); cerebral cortex: 23.6364% (minimum 75%, Missing); choroid plexus: 21.4876% (minimum 75%, Missing); heart muscle: 67.8261% (minimum 70%, Approved); hippocampal formation: 27.3684% (minimum 75%, Missing); hypothalamus: 27.6596% (minimum 75%, Missing); midbrain: 39.1960% (minimum 75%, Missing); pituitary gland: 22.0339% (minimum 75%, Missing); retina: 39.1960% (minimum 75%, Missing); smooth muscle: 63.9344% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing)",0.0190476,0.1,-0.535124,0,2,partial,28.5,2.6,4.8,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 2); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 2); kidney: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); salivary gland / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169169,CPT1C,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.0000% (minimum 70%, Approved); amygdala: 30.1158% (minimum 75%, Missing); basal ganglia: 24.8408% (minimum 75%, Missing); cerebellum: 22.5434% (minimum 75%, Missing); cerebral cortex: 23.6364% (minimum 75%, Missing); choroid plexus: 21.4876% (minimum 75%, Missing); heart muscle: 67.8261% (minimum 70%, Approved); hippocampal formation: 27.3684% (minimum 75%, Missing); hypothalamus: 27.6596% (minimum 75%, Missing); midbrain: 39.1960% (minimum 75%, Missing); pituitary gland: 22.0339% (minimum 75%, Missing); retina: 39.1960% (minimum 75%, Missing); smooth muscle: 63.9344% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing)",0.0190476,0.1,-0.535124,0,2,partial,28.5,2.6,4.8,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 2); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 2); kidney: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); salivary gland / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169169,CPT1C,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 30.1158% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 24.8408% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 22.5434% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 23.6364% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 21.4876% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 67.8261% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 27.3684% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 27.6596% (minimum 75%, Baseline (adaptation disabled)); midbrain: 39.1960% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 22.0339% (minimum 75%, Baseline (adaptation disabled)); retina: 39.1960% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.9344% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 40.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.9048% (minimum 65%, Baseline (adaptation disabled))",-0.0309524,0.05,-0.535124,0,2,partial,28.5,2.6,4.8,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); salivary gland / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169169,CPT1C,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.0333333,0.0215966,0.00159664,0,80,unavailable,0.2,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169194,IL13,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333333,0.291597,0.241597,0,80,unavailable,0.2,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169194,IL13,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333333,0.291597,0.241597,0,80,unavailable,0.2,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169194,IL13,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333333,0.291597,0.241597,0,80,unavailable,0.2,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169194,IL13,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333333,0.291597,0.241597,0,80,unavailable,0.2,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169194,IL13,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169214,OR6F1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169214,OR6F1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169214,OR6F1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169214,OR6F1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169214,OR6F1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Uncertain); adrenal gland: 94.3396% (minimum 99%, Uncertain); amygdala: 35.7143% (minimum 99%, Missing); basal ganglia: 72.4638% (minimum 99%, Missing); bone marrow: 94.3396% (minimum 99%, Uncertain); cerebellum: 92.5926% (minimum 99%, Uncertain); cerebral cortex: 48.0769% (minimum 99%, Uncertain); choroid plexus: 94.3396% (minimum 99%, Missing); colon: 75.7576% (minimum 97%, Uncertain); duodenum: 86.2069% (minimum 99%, Uncertain); esophagus: 83.3333% (minimum 97%, Uncertain); heart muscle: 80.6452% (minimum 99%, Uncertain); hippocampal formation: 61.7284% (minimum 99%, Missing); hypothalamus: 58.1395% (minimum 99%, Missing); kidney: 79.3651% (minimum 99%, Uncertain); liver: 68.4932% (minimum 99%, Uncertain); lung: 46.2963% (minimum 99%, Uncertain); lymph node: 30.1205% (minimum 97%, Uncertain); midbrain: 64.9351% (minimum 99%, Missing); pancreas: 36.7647% (minimum 99%, Uncertain); pituitary gland: 96.1538% (minimum 99%, Missing); rectum: 54.3478% (minimum 97%, Uncertain); salivary gland: 62.5000% (minimum 97%, Uncertain); skeletal muscle: 94.3396% (minimum 99%, Uncertain); small intestine: 80.6452% (minimum 99%, Uncertain); smooth muscle: 75.7576% (minimum 99%, Uncertain); spinal cord: 48.0769% (minimum 99%, Missing); spleen: 47.1698% (minimum 95%, Uncertain); stomach: 45.0450% (minimum 97%, Uncertain); thymus: 44.6429% (minimum 95%, Missing); thyroid gland: 80.6452% (minimum 95%, Uncertain); urinary bladder: 52.6316% (minimum 97%, Uncertain)",-0.503571,-0.668795,-0.632857,0,0,routine_complete,9,11.6,6.2,"lymph node: 11.6 nTPM (protected, limit 2); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); stomach: 6.1 nTPM (protected, limit 2); lung: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169248,CXCL11,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 35.7143% (minimum 75%, Missing); basal ganglia: 72.4638% (minimum 75%, Missing); cerebral cortex: 48.0769% (minimum 75%, Uncertain); hippocampal formation: 61.7284% (minimum 75%, Missing); hypothalamus: 58.1395% (minimum 75%, Missing); liver: 68.4932% (minimum 75%, Uncertain); lung: 46.2963% (minimum 75%, Uncertain); lymph node: 30.1205% (minimum 70%, Uncertain); midbrain: 64.9351% (minimum 75%, Missing); pancreas: 36.7647% (minimum 75%, Uncertain); rectum: 54.3478% (minimum 70%, Uncertain); salivary gland: 62.5000% (minimum 70%, Uncertain); spinal cord: 48.0769% (minimum 75%, Missing); spleen: 47.1698% (minimum 65%, Uncertain); stomach: 45.0450% (minimum 70%, Uncertain); thymus: 44.6429% (minimum 65%, Missing); urinary bladder: 52.6316% (minimum 70%, Uncertain)",-0.203571,-0.398795,-0.392857,0,0,routine_complete,9,11.6,6.2,"lymph node: 11.6 nTPM (protected, limit 2); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); stomach: 6.1 nTPM (protected, limit 2); lung: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169248,CXCL11,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 35.7143% (minimum 75%, Missing); basal ganglia: 72.4638% (minimum 75%, Missing); cerebral cortex: 48.0769% (minimum 75%, Uncertain); hippocampal formation: 61.7284% (minimum 75%, Missing); hypothalamus: 58.1395% (minimum 75%, Missing); liver: 68.4932% (minimum 75%, Uncertain); lung: 46.2963% (minimum 75%, Uncertain); lymph node: 30.1205% (minimum 70%, Uncertain); midbrain: 64.9351% (minimum 75%, Missing); pancreas: 36.7647% (minimum 75%, Uncertain); rectum: 54.3478% (minimum 70%, Uncertain); salivary gland: 62.5000% (minimum 70%, Uncertain); spinal cord: 48.0769% (minimum 75%, Missing); spleen: 47.1698% (minimum 65%, Uncertain); stomach: 45.0450% (minimum 70%, Uncertain); thymus: 44.6429% (minimum 65%, Missing); urinary bladder: 52.6316% (minimum 70%, Uncertain)",-0.203571,-0.398795,-0.392857,0,0,routine_complete,9,11.6,6.2,"lymph node: 11.6 nTPM (protected, limit 3); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); stomach: 6.1 nTPM (protected, limit 3); lung: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169248,CXCL11,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 35.7143% (minimum 75%, Missing); basal ganglia: 72.4638% (minimum 75%, Missing); cerebral cortex: 48.0769% (minimum 75%, Uncertain); hippocampal formation: 61.7284% (minimum 75%, Missing); hypothalamus: 58.1395% (minimum 75%, Missing); liver: 68.4932% (minimum 75%, Uncertain); lung: 46.2963% (minimum 75%, Uncertain); lymph node: 30.1205% (minimum 70%, Uncertain); midbrain: 64.9351% (minimum 75%, Missing); pancreas: 36.7647% (minimum 75%, Uncertain); rectum: 54.3478% (minimum 70%, Uncertain); salivary gland: 62.5000% (minimum 70%, Uncertain); spinal cord: 48.0769% (minimum 75%, Missing); spleen: 47.1698% (minimum 65%, Uncertain); stomach: 45.0450% (minimum 70%, Uncertain); thymus: 44.6429% (minimum 65%, Missing); urinary bladder: 52.6316% (minimum 70%, Uncertain)",-0.203571,-0.398795,-0.392857,0,0,routine_complete,9,11.6,6.2,"lymph node: 11.6 nTPM (protected, limit 3); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); stomach: 6.1 nTPM (protected, limit 3); lung: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169248,CXCL11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 35.7143% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 72.4638% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.0769% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.7284% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.1395% (minimum 75%, Baseline (adaptation disabled)); liver: 68.4932% (minimum 75%, Baseline (adaptation disabled)); lung: 46.2963% (minimum 75%, Baseline (adaptation disabled)); lymph node: 30.1205% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.9351% (minimum 75%, Baseline (adaptation disabled)); pancreas: 36.7647% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.3478% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 70%, Baseline (adaptation disabled)); spinal cord: 48.0769% (minimum 75%, Baseline (adaptation disabled)); spleen: 47.1698% (minimum 65%, Baseline (adaptation disabled)); stomach: 45.0450% (minimum 70%, Baseline (adaptation disabled)); thymus: 44.6429% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 52.6316% (minimum 70%, Baseline (adaptation disabled))",-0.203571,-0.398795,-0.392857,0,0,routine_complete,9,11.6,6.2,"lymph node: 11.6 nTPM (protected, limit 3); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); stomach: 6.1 nTPM (protected, limit 3); lung: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169248,CXCL11,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 97.8261% (minimum 98%, Approved); small intestine: 97.8261% (minimum 98%, Approved); stomach: 13.1004% (minimum 97%, Missing)",0.05,-0.838996,-0.00173913,0,1,partial,0.4,119.4,0.1,"stomach: 119.4 nTPM (protected, limit 2)",stomach 2 / glandular cells: Low (Approved),55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169340,PDILT,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"stomach: 13.1004% (minimum 70%, Missing)",0.35,-0.568996,0.25,0,1,partial,0.4,119.4,0.1,"stomach: 119.4 nTPM (protected, limit 2)",stomach 2 / glandular cells: Low (Approved),55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169340,PDILT,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"stomach: 13.1004% (minimum 70%, Missing)",0.35,-0.568996,0.25,0,1,partial,0.4,119.4,0.1,"stomach: 119.4 nTPM (protected, limit 3)",stomach 2 / glandular cells: Low (Approved),55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169340,PDILT,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"stomach: 13.1004% (minimum 70%, Missing)",0.35,-0.568996,0.25,0,1,partial,0.4,119.4,0.1,"stomach: 119.4 nTPM (protected, limit 3)",stomach 2 / glandular cells: Low (Approved),55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169340,PDILT,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"stomach: 13.1004% (minimum 70%, Baseline (adaptation disabled))",0.344475,-0.568996,0.228261,0,1,partial,0.4,119.4,0.1,"stomach: 119.4 nTPM (protected, limit 3)",stomach 2 / glandular cells: Low (Approved),55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169340,PDILT,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.4473% (minimum 99%, Missing)",0.05,0.03,-0.015527,0,1,partial,72.3,0,0,"retina: 72.3 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169393,ELSPBP1,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224473,0,1,partial,72.3,0,0,"retina: 72.3 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169393,ELSPBP1,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224473,0,1,partial,72.3,0,0,"retina: 72.3 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169393,ELSPBP1,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224473,0,1,partial,72.3,0,0,"retina: 72.3 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169393,ELSPBP1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224473,0,1,partial,72.3,0,0,"retina: 72.3 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169393,ELSPBP1,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.9275% (minimum 99%, Missing); basal ganglia: 95.9391% (minimum 99%, Missing); choroid plexus: 84.0000% (minimum 99%, Missing); hippocampal formation: 95.9391% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); lung: 93.5644% (minimum 97%, Supported); pituitary gland: 96.9231% (minimum 99%, Missing); retina: 98.9529% (minimum 99%, Missing); spinal cord: 98.9529% (minimum 99%, Missing)",0.05,0.03,-0.15,0,4,partial,3.6,1.2,0.3,"choroid plexus: 3.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169402,RSPH10B2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.09,0,4,partial,3.6,1.2,0.3,"choroid plexus: 3.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169402,RSPH10B2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.09,0,4,partial,3.6,1.2,0.3,"choroid plexus: 3.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169402,RSPH10B2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.09,0,4,partial,3.6,1.2,0.3,"choroid plexus: 3.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169402,RSPH10B2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.334375,0.240299,0.09,0,4,partial,3.6,1.2,0.3,"choroid plexus: 3.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169402,RSPH10B2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.4628% (minimum 95%, Enhanced); retina: 98.6239% (minimum 99%, Missing)",0.0438367,0.0238367,-0.0453717,0,5,partial,6.8,2.2,1,"bone marrow: 6.8 nTPM (vital, limit 6)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169495,HTRA4,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343837,0.293837,0.236239,0,5,partial,6.8,2.2,1,"bone marrow: 6.8 nTPM (vital, limit 6)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169495,HTRA4,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343837,0.293837,0.236239,0,5,partial,6.8,2.2,1,"bone marrow: 6.8 nTPM (vital, limit 6)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169495,HTRA4,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343837,0.293837,0.236239,0,5,partial,6.8,2.2,1,"bone marrow: 6.8 nTPM (vital, limit 6)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169495,HTRA4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334733,0.267016,0.154628,0,5,partial,6.8,2.2,1,"bone marrow: 6.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169495,HTRA4,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 94.8718% (minimum 99%, Missing); basal ganglia: 92.5000% (minimum 99%, Missing); cerebral cortex: 92.5000% (minimum 99%, Missing); hippocampal formation: 92.5000% (minimum 99%, Missing); hypothalamus: 94.8718% (minimum 99%, Missing); midbrain: 97.3684% (minimum 99%, Missing); retina: 97.3684% (minimum 99%, Missing)",0.0236842,0.03,-0.065,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169551,CT55,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
True,compatible,,True,True,True,,0.323684,0.3,0.175,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169551,CT55,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
True,compatible,,True,True,True,,0.323684,0.3,0.175,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169551,CT55,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
True,compatible,,True,True,True,,0.323684,0.3,0.175,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169551,CT55,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
True,compatible,,True,True,True,,0.323684,0.3,0.175,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169551,CT55,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.0253% (minimum 90%, Approved); adrenal gland: 60.4938% (minimum 99%, Missing); amygdala: 77.7778% (minimum 99%, Missing); basal ganglia: 76.5625% (minimum 99%, Missing); bone marrow: 80.3279% (minimum 99%, Missing); cerebellum: 63.6364% (minimum 98%, Approved); cerebral cortex: 66.2162% (minimum 98%, Approved); choroid plexus: 85.9649% (minimum 99%, Missing); colon: 61.2500% (minimum 97%, Missing); duodenum: 62.0253% (minimum 99%, Missing); esophagus: 54.4444% (minimum 97%, Missing); heart muscle: 43.7500% (minimum 99%, Missing); hippocampal formation: 76.5625% (minimum 99%, Missing); hypothalamus: 79.0323% (minimum 99%, Missing); kidney: 44.1441% (minimum 99%, Missing); liver: 53.2609% (minimum 98%, Approved); lung: 68.0556% (minimum 98%, Approved); lymph node: 69.0141% (minimum 95%, Approved); midbrain: 77.7778% (minimum 99%, Missing); pancreas: 62.8205% (minimum 99%, Missing); parathyroid gland: 52.1277% (minimum 95%, Approved); pituitary gland: 85.9649% (minimum 99%, Missing); rectum: 60.4938% (minimum 97%, Missing); retina: 59.7561% (minimum 99%, Missing); salivary gland: 61.2500% (minimum 97%, Missing); skeletal muscle: 32.8859% (minimum 98%, Approved); skin: 60.4938% (minimum 95%, Missing); small intestine: 65.3333% (minimum 99%, Missing); smooth muscle: 62.0253% (minimum 98%, Approved); spinal cord: 72.0588% (minimum 99%, Missing); spleen: 62.8205% (minimum 95%, Missing); stomach: 65.3333% (minimum 97%, Missing); thymus: 72.0588% (minimum 95%, Missing); thyroid gland: 36.0294% (minimum 90%, Approved); tongue: 44.5455% (minimum 97%, Missing); urinary bladder: 63.6364% (minimum 97%, Missing)",-0.539706,-0.524545,-0.651141,0,5,partial,10,6.1,8.7,"skeletal muscle: 10 nTPM (vital, limit 2); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 4); liver: 4.3 nTPM (vital, limit 2); esophagus: 4.1 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); colon: 3.1 nTPM (protected, limit 2); smooth muscle: 3 nTPM (vital, limit 2); duodenum: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); cerebellum: 2.8 nTPM (vital, limit 2); small intestine: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169570,DTWD2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.4938% (minimum 75%, Missing); cerebellum: 63.6364% (minimum 70%, Approved); cerebral cortex: 66.2162% (minimum 70%, Approved); colon: 61.2500% (minimum 70%, Missing); duodenum: 62.0253% (minimum 75%, Missing); esophagus: 54.4444% (minimum 70%, Missing); heart muscle: 43.7500% (minimum 75%, Missing); kidney: 44.1441% (minimum 75%, Missing); liver: 53.2609% (minimum 70%, Approved); lung: 68.0556% (minimum 70%, Approved); pancreas: 62.8205% (minimum 75%, Missing); parathyroid gland: 52.1277% (minimum 65%, Approved); rectum: 60.4938% (minimum 70%, Missing); retina: 59.7561% (minimum 75%, Missing); salivary gland: 61.2500% (minimum 70%, Missing); skeletal muscle: 32.8859% (minimum 70%, Approved); skin: 60.4938% (minimum 65%, Missing); small intestine: 65.3333% (minimum 75%, Missing); smooth muscle: 62.0253% (minimum 70%, Approved); spinal cord: 72.0588% (minimum 75%, Missing); spleen: 62.8205% (minimum 65%, Missing); stomach: 65.3333% (minimum 70%, Missing); thyroid gland: 36.0294% (minimum 60%, Approved); tongue: 44.5455% (minimum 70%, Missing); urinary bladder: 63.6364% (minimum 70%, Missing)",-0.239706,-0.254545,-0.371141,0,5,partial,10,6.1,8.7,"skeletal muscle: 10 nTPM (vital, limit 2); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 4); liver: 4.3 nTPM (vital, limit 2); esophagus: 4.1 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); colon: 3.1 nTPM (protected, limit 2); smooth muscle: 3 nTPM (vital, limit 2); duodenum: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); cerebellum: 2.8 nTPM (vital, limit 2); small intestine: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169570,DTWD2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.4938% (minimum 75%, Missing); cerebellum: 63.6364% (minimum 70%, Approved); cerebral cortex: 66.2162% (minimum 70%, Approved); colon: 61.2500% (minimum 70%, Missing); duodenum: 62.0253% (minimum 75%, Missing); esophagus: 54.4444% (minimum 70%, Missing); heart muscle: 43.7500% (minimum 75%, Missing); kidney: 44.1441% (minimum 75%, Missing); liver: 53.2609% (minimum 70%, Approved); lung: 68.0556% (minimum 70%, Approved); pancreas: 62.8205% (minimum 75%, Missing); parathyroid gland: 52.1277% (minimum 65%, Approved); rectum: 60.4938% (minimum 70%, Missing); retina: 59.7561% (minimum 75%, Missing); salivary gland: 61.2500% (minimum 70%, Missing); skeletal muscle: 32.8859% (minimum 70%, Approved); skin: 60.4938% (minimum 65%, Missing); small intestine: 65.3333% (minimum 75%, Missing); smooth muscle: 62.0253% (minimum 70%, Approved); spinal cord: 72.0588% (minimum 75%, Missing); spleen: 62.8205% (minimum 65%, Missing); stomach: 65.3333% (minimum 70%, Missing); thyroid gland: 36.0294% (minimum 60%, Approved); tongue: 44.5455% (minimum 70%, Missing); urinary bladder: 63.6364% (minimum 70%, Missing)",-0.239706,-0.254545,-0.371141,0,5,partial,10,6.1,8.7,"skeletal muscle: 10 nTPM (vital, limit 2); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 4); liver: 4.3 nTPM (vital, limit 2); esophagus: 4.1 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); salivary gland: 3.1 nTPM (protected, limit 3); colon: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 2); pancreas: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 2); small intestine: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169570,DTWD2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.4938% (minimum 75%, Missing); cerebellum: 63.6364% (minimum 70%, Approved); cerebral cortex: 66.2162% (minimum 70%, Approved); colon: 61.2500% (minimum 70%, Missing); duodenum: 62.0253% (minimum 75%, Missing); esophagus: 54.4444% (minimum 70%, Missing); heart muscle: 43.7500% (minimum 75%, Missing); kidney: 44.1441% (minimum 75%, Missing); liver: 53.2609% (minimum 70%, Approved); lung: 68.0556% (minimum 70%, Approved); pancreas: 62.8205% (minimum 75%, Missing); parathyroid gland: 52.1277% (minimum 65%, Approved); rectum: 60.4938% (minimum 70%, Missing); retina: 59.7561% (minimum 75%, Missing); salivary gland: 61.2500% (minimum 70%, Missing); skeletal muscle: 32.8859% (minimum 70%, Approved); skin: 60.4938% (minimum 65%, Missing); small intestine: 65.3333% (minimum 75%, Missing); smooth muscle: 62.0253% (minimum 70%, Approved); spinal cord: 72.0588% (minimum 75%, Missing); spleen: 62.8205% (minimum 65%, Missing); stomach: 65.3333% (minimum 70%, Missing); thyroid gland: 36.0294% (minimum 60%, Approved); tongue: 44.5455% (minimum 70%, Missing); urinary bladder: 63.6364% (minimum 70%, Missing)",-0.239706,-0.254545,-0.371141,0,5,partial,10,6.1,8.7,"skeletal muscle: 10 nTPM (vital, limit 2); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 4); liver: 4.3 nTPM (vital, limit 2); esophagus: 4.1 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); salivary gland: 3.1 nTPM (protected, limit 3); colon: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 2); pancreas: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 2); small intestine: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169570,DTWD2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.0253% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.4938% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 63.6364% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.2162% (minimum 75%, Baseline (adaptation disabled)); colon: 61.2500% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.0253% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.4444% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 43.7500% (minimum 75%, Baseline (adaptation disabled)); kidney: 44.1441% (minimum 75%, Baseline (adaptation disabled)); liver: 53.2609% (minimum 75%, Baseline (adaptation disabled)); lung: 68.0556% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.0141% (minimum 70%, Baseline (adaptation disabled)); pancreas: 62.8205% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.1277% (minimum 70%, Baseline (adaptation disabled)); rectum: 60.4938% (minimum 70%, Baseline (adaptation disabled)); retina: 59.7561% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.2500% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 32.8859% (minimum 75%, Baseline (adaptation disabled)); skin: 60.4938% (minimum 65%, Baseline (adaptation disabled)); small intestine: 65.3333% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.0253% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.0588% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.8205% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.3333% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 36.0294% (minimum 65%, Baseline (adaptation disabled)); tongue: 44.5455% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.6364% (minimum 70%, Baseline (adaptation disabled))",-0.289706,-0.254545,-0.421141,0,5,partial,10,6.1,8.7,"skeletal muscle: 10 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 3); liver: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); colon: 3.1 nTPM (protected, limit 3); salivary gland: 3.1 nTPM (protected, limit 3); smooth muscle: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169570,DTWD2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 0.3390% (minimum 99%, Missing); lymph node: 16.6667% (minimum 95%, Approved); small intestine: 50.0000% (minimum 98%, Approved); thymus: 8.3333% (minimum 95%, Missing)",-0.866667,-0.783333,-0.98661,0,1,partial,29.4,0.5,1.1,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169575,VPREB1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 0.3390% (minimum 75%, Missing); lymph node: 16.6667% (minimum 65%, Approved); small intestine: 50.0000% (minimum 70%, Approved); thymus: 8.3333% (minimum 65%, Missing)",-0.566667,-0.483333,-0.74661,0,1,partial,29.4,0.5,1.1,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169575,VPREB1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 0.3390% (minimum 75%, Missing); lymph node: 16.6667% (minimum 65%, Approved); small intestine: 50.0000% (minimum 70%, Approved); thymus: 8.3333% (minimum 65%, Missing)",-0.566667,-0.483333,-0.74661,0,1,partial,29.4,0.5,1.1,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169575,VPREB1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 0.3390% (minimum 75%, Missing); lymph node: 16.6667% (minimum 65%, Approved); small intestine: 50.0000% (minimum 70%, Approved); thymus: 8.3333% (minimum 65%, Missing)",-0.566667,-0.483333,-0.74661,0,1,partial,29.4,0.5,1.1,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169575,VPREB1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 0.3390% (minimum 75%, Baseline (adaptation disabled)); lymph node: 16.6667% (minimum 70%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 75%, Baseline (adaptation disabled)); thymus: 8.3333% (minimum 65%, Baseline (adaptation disabled))",-0.566667,-0.533333,-0.74661,0,1,partial,29.4,0.5,1.1,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169575,VPREB1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6598% (minimum 95%, Missing); esophagus: 66.7575% (minimum 97%, Missing); heart muscle: 94.9612% (minimum 99%, Missing); lung: 98.7903% (minimum 99%, Missing); parathyroid gland: 96.4567% (minimum 97%, Missing); salivary gland: 92.8030% (minimum 97%, Missing); skin: 73.1343% (minimum 95%, Missing); thymus: 86.5724% (minimum 95%, Missing)",-0.323402,-0.302425,-0.0403876,0,80,unavailable,1.3,12.2,14.6,"adipose tissue: 14.6 nTPM (manageable, limit 5); esophagus: 12.2 nTPM (protected, limit 2); skin: 9 nTPM (manageable, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169594,BNC1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6598% (minimum 65%, Missing); esophagus: 66.7575% (minimum 70%, Missing)",-0.0234015,-0.0324251,0.199612,0,80,unavailable,1.3,12.2,14.6,"adipose tissue: 14.6 nTPM (manageable, limit 5); esophagus: 12.2 nTPM (protected, limit 2); skin: 9 nTPM (manageable, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169594,BNC1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6598% (minimum 65%, Missing); esophagus: 66.7575% (minimum 70%, Missing)",-0.0234015,-0.0324251,0.199612,0,80,unavailable,1.3,12.2,14.6,"adipose tissue: 14.6 nTPM (manageable, limit 5); esophagus: 12.2 nTPM (protected, limit 3); skin: 9 nTPM (manageable, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169594,BNC1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6598% (minimum 65%, Missing); esophagus: 66.7575% (minimum 70%, Missing)",-0.0234015,-0.0324251,0.199612,0,80,unavailable,1.3,12.2,14.6,"adipose tissue: 14.6 nTPM (manageable, limit 5); esophagus: 12.2 nTPM (protected, limit 3); skin: 9 nTPM (manageable, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169594,BNC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6598% (minimum 65%, Baseline (adaptation disabled)); esophagus: 66.7575% (minimum 70%, Baseline (adaptation disabled))",-0.0234015,-0.0324251,0.199612,0,80,unavailable,1.3,12.2,14.6,"adipose tissue: 14.6 nTPM (manageable, limit 5); esophagus: 12.2 nTPM (protected, limit 3); skin: 9 nTPM (manageable, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169594,BNC1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Uncertain); adrenal gland: 97.7778% (minimum 99%, Missing); bone marrow: 25.2874% (minimum 99%, Missing); cerebral cortex: 91.6667% (minimum 99%, Missing); colon: 74.5763% (minimum 97%, Missing); duodenum: 74.5763% (minimum 99%, Missing); esophagus: 65.6716% (minimum 97%, Missing); kidney: 97.7778% (minimum 99%, Missing); liver: 93.6170% (minimum 99%, Uncertain); lung: 93.6170% (minimum 99%, Missing); lymph node: 47.3118% (minimum 97%, Missing); rectum: 67.6923% (minimum 97%, Missing); retina: 95.6522% (minimum 99%, Missing); salivary gland: 93.6170% (minimum 97%, Missing); skin: 74.5763% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 81.4815% (minimum 99%, Missing); spleen: 84.6154% (minimum 95%, Uncertain); stomach: 81.4815% (minimum 97%, Missing); thymus: 27.3292% (minimum 95%, Missing); thyroid gland: 93.6170% (minimum 95%, Missing); urinary bladder: 86.2745% (minimum 97%, Missing)",-0.676708,-0.496882,-0.737126,0,3,partial,13,4.9,11.7,"bone marrow: 13 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169607,CKAP2L,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.2874% (minimum 75%, Missing); duodenum: 74.5763% (minimum 75%, Missing); esophagus: 65.6716% (minimum 70%, Missing); lymph node: 47.3118% (minimum 70%, Missing); rectum: 67.6923% (minimum 70%, Missing); thymus: 27.3292% (minimum 65%, Missing)",-0.376708,-0.226882,-0.497126,0,3,partial,13,4.9,11.7,"bone marrow: 13 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169607,CKAP2L,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.2874% (minimum 75%, Missing); duodenum: 74.5763% (minimum 75%, Missing); esophagus: 65.6716% (minimum 70%, Missing); lymph node: 47.3118% (minimum 70%, Missing); rectum: 67.6923% (minimum 70%, Missing); thymus: 27.3292% (minimum 65%, Missing)",-0.376708,-0.226882,-0.497126,0,3,partial,13,4.9,11.7,"bone marrow: 13 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 3); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169607,CKAP2L,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.2874% (minimum 75%, Missing); duodenum: 74.5763% (minimum 75%, Missing); esophagus: 65.6716% (minimum 70%, Missing); lymph node: 47.3118% (minimum 70%, Missing); rectum: 67.6923% (minimum 70%, Missing); thymus: 27.3292% (minimum 65%, Missing)",-0.376708,-0.226882,-0.497126,0,3,partial,13,4.9,11.7,"bone marrow: 13 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 3); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169607,CKAP2L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.2874% (minimum 75%, Baseline (adaptation disabled)); duodenum: 74.5763% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.6716% (minimum 70%, Baseline (adaptation disabled)); lymph node: 47.3118% (minimum 70%, Baseline (adaptation disabled)); rectum: 67.6923% (minimum 70%, Baseline (adaptation disabled)); thymus: 27.3292% (minimum 65%, Baseline (adaptation disabled))",-0.376708,-0.226882,-0.497126,0,3,partial,13,4.9,11.7,"bone marrow: 13 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 3); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169607,CKAP2L,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.6207% (minimum 95%, Uncertain); adrenal gland: 65.3846% (minimum 99%, Uncertain); amygdala: 80.9524% (minimum 99%, Missing); basal ganglia: 77.2727% (minimum 99%, Missing); bone marrow: 70.8333% (minimum 99%, Uncertain); cerebral cortex: 80.9524% (minimum 99%, Uncertain); choroid plexus: 89.4737% (minimum 99%, Missing); colon: 62.9630% (minimum 97%, Uncertain); duodenum: 73.9130% (minimum 99%, Uncertain); esophagus: 54.8387% (minimum 97%, Uncertain); heart muscle: 68.0000% (minimum 99%, Uncertain); hippocampal formation: 77.2727% (minimum 99%, Missing); hypothalamus: 89.4737% (minimum 99%, Missing); kidney: 65.3846% (minimum 99%, Uncertain); liver: 53.1250% (minimum 99%, Uncertain); lung: 65.3846% (minimum 99%, Uncertain); lymph node: 58.6207% (minimum 97%, Uncertain); midbrain: 85.0000% (minimum 99%, Missing); pancreas: 73.9130% (minimum 99%, Uncertain); parathyroid gland: 68.0000% (minimum 97%, Uncertain); pituitary gland: 80.9524% (minimum 99%, Missing); rectum: 68.0000% (minimum 97%, Uncertain); retina: 80.9524% (minimum 99%, Missing); salivary gland: 60.7143% (minimum 97%, Uncertain); skeletal muscle: 62.9630% (minimum 99%, Uncertain); skin: 42.5000% (minimum 95%, Uncertain); small intestine: 77.2727% (minimum 99%, Uncertain); smooth muscle: 60.7143% (minimum 99%, Uncertain); spinal cord: 89.4737% (minimum 99%, Missing); spleen: 68.0000% (minimum 95%, Uncertain); stomach: 70.8333% (minimum 97%, Uncertain); thymus: 68.0000% (minimum 95%, Missing); thyroid gland: 60.7143% (minimum 95%, Uncertain); tongue: 58.6207% (minimum 97%, Missing); urinary bladder: 62.9630% (minimum 97%, Uncertain)",-0.525,-0.421613,-0.45875,0,0,routine_complete,1.5,1.4,2.3,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169621,APLF,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.6207% (minimum 65%, Uncertain); adrenal gland: 65.3846% (minimum 75%, Uncertain); bone marrow: 70.8333% (minimum 75%, Uncertain); colon: 62.9630% (minimum 70%, Uncertain); duodenum: 73.9130% (minimum 75%, Uncertain); esophagus: 54.8387% (minimum 70%, Uncertain); heart muscle: 68.0000% (minimum 75%, Uncertain); kidney: 65.3846% (minimum 75%, Uncertain); liver: 53.1250% (minimum 75%, Uncertain); lung: 65.3846% (minimum 75%, Uncertain); lymph node: 58.6207% (minimum 70%, Uncertain); pancreas: 73.9130% (minimum 75%, Uncertain); parathyroid gland: 68.0000% (minimum 70%, Uncertain); rectum: 68.0000% (minimum 70%, Uncertain); salivary gland: 60.7143% (minimum 70%, Uncertain); skeletal muscle: 62.9630% (minimum 75%, Uncertain); skin: 42.5000% (minimum 65%, Uncertain); smooth muscle: 60.7143% (minimum 75%, Uncertain); thyroid gland: 60.7143% (minimum 65%, Uncertain); tongue: 58.6207% (minimum 70%, Missing); urinary bladder: 62.9630% (minimum 70%, Uncertain)",-0.225,-0.151613,-0.21875,0,0,routine_complete,1.5,1.4,2.3,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169621,APLF,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.6207% (minimum 65%, Uncertain); adrenal gland: 65.3846% (minimum 75%, Uncertain); bone marrow: 70.8333% (minimum 75%, Uncertain); colon: 62.9630% (minimum 70%, Uncertain); duodenum: 73.9130% (minimum 75%, Uncertain); esophagus: 54.8387% (minimum 70%, Uncertain); heart muscle: 68.0000% (minimum 75%, Uncertain); kidney: 65.3846% (minimum 75%, Uncertain); liver: 53.1250% (minimum 75%, Uncertain); lung: 65.3846% (minimum 75%, Uncertain); lymph node: 58.6207% (minimum 70%, Uncertain); pancreas: 73.9130% (minimum 75%, Uncertain); parathyroid gland: 68.0000% (minimum 70%, Uncertain); rectum: 68.0000% (minimum 70%, Uncertain); salivary gland: 60.7143% (minimum 70%, Uncertain); skeletal muscle: 62.9630% (minimum 75%, Uncertain); skin: 42.5000% (minimum 65%, Uncertain); smooth muscle: 60.7143% (minimum 75%, Uncertain); thyroid gland: 60.7143% (minimum 65%, Uncertain); tongue: 58.6207% (minimum 70%, Missing); urinary bladder: 62.9630% (minimum 70%, Uncertain)",-0.225,-0.151613,-0.21875,0,0,routine_complete,1.5,1.4,2.3,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169621,APLF,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.6207% (minimum 65%, Uncertain); adrenal gland: 65.3846% (minimum 75%, Uncertain); bone marrow: 70.8333% (minimum 75%, Uncertain); colon: 62.9630% (minimum 70%, Uncertain); duodenum: 73.9130% (minimum 75%, Uncertain); esophagus: 54.8387% (minimum 70%, Uncertain); heart muscle: 68.0000% (minimum 75%, Uncertain); kidney: 65.3846% (minimum 75%, Uncertain); liver: 53.1250% (minimum 75%, Uncertain); lung: 65.3846% (minimum 75%, Uncertain); lymph node: 58.6207% (minimum 70%, Uncertain); pancreas: 73.9130% (minimum 75%, Uncertain); parathyroid gland: 68.0000% (minimum 70%, Uncertain); rectum: 68.0000% (minimum 70%, Uncertain); salivary gland: 60.7143% (minimum 70%, Uncertain); skeletal muscle: 62.9630% (minimum 75%, Uncertain); skin: 42.5000% (minimum 65%, Uncertain); smooth muscle: 60.7143% (minimum 75%, Uncertain); thyroid gland: 60.7143% (minimum 65%, Uncertain); tongue: 58.6207% (minimum 70%, Missing); urinary bladder: 62.9630% (minimum 70%, Uncertain)",-0.225,-0.151613,-0.21875,0,0,routine_complete,1.5,1.4,2.3,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169621,APLF,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.6207% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 65.3846% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 70.8333% (minimum 75%, Baseline (adaptation disabled)); colon: 62.9630% (minimum 70%, Baseline (adaptation disabled)); duodenum: 73.9130% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.8387% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.3846% (minimum 75%, Baseline (adaptation disabled)); liver: 53.1250% (minimum 75%, Baseline (adaptation disabled)); lung: 65.3846% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.6207% (minimum 70%, Baseline (adaptation disabled)); pancreas: 73.9130% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 68.0000% (minimum 70%, Baseline (adaptation disabled)); rectum: 68.0000% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 60.7143% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 62.9630% (minimum 75%, Baseline (adaptation disabled)); skin: 42.5000% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 60.7143% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 60.7143% (minimum 65%, Baseline (adaptation disabled)); tongue: 58.6207% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.9630% (minimum 70%, Baseline (adaptation disabled))",-0.225,-0.151613,-0.21875,0,0,routine_complete,1.5,1.4,2.3,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169621,APLF,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6577% (minimum 99%, Missing); bone marrow: 71.5328% (minimum 99%, Missing); cerebral cortex: 98.0000% (minimum 99%, Missing); colon: 87.5000% (minimum 97%, Missing); duodenum: 88.5542% (minimum 99%, Missing); esophagus: 86.7257% (minimum 97%, Missing); heart muscle: 98.0000% (minimum 99%, Missing); kidney: 98.9899% (minimum 99%, Missing); liver: 98.3278% (minimum 99%, Missing); lung: 96.0784% (minimum 99%, Missing); lymph node: 65.3333% (minimum 97%, Missing); rectum: 84.2407% (minimum 97%, Missing); skin: 91.8750% (minimum 95%, Missing); small intestine: 89.6341% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spinal cord: 98.9899% (minimum 99%, Missing); spleen: 84.2407% (minimum 95%, Missing); stomach: 93.9297% (minimum 97%, Missing); thymus: 52.3132% (minimum 95%, Missing); urinary bladder: 92.4528% (minimum 97%, Missing)",-0.426868,-0.316667,-0.274672,0,80,unavailable,11.7,15.6,26.8,"thymus: 26.8 nTPM (manageable, limit 5); lymph node: 15.6 nTPM (protected, limit 2); bone marrow: 11.7 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); spleen: 5.5 nTPM (manageable, limit 5); esophagus: 4.5 nTPM (protected, limit 2); colon: 4.2 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169679,BUB1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 71.5328% (minimum 75%, Missing); lymph node: 65.3333% (minimum 70%, Missing); thymus: 52.3132% (minimum 65%, Missing)",-0.126868,-0.0466667,-0.0346715,0,80,unavailable,11.7,15.6,26.8,"thymus: 26.8 nTPM (manageable, limit 5); lymph node: 15.6 nTPM (protected, limit 2); bone marrow: 11.7 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); spleen: 5.5 nTPM (manageable, limit 5); esophagus: 4.5 nTPM (protected, limit 2); colon: 4.2 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169679,BUB1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 71.5328% (minimum 75%, Missing); lymph node: 65.3333% (minimum 70%, Missing); thymus: 52.3132% (minimum 65%, Missing)",-0.126868,-0.0466667,-0.0346715,0,80,unavailable,11.7,15.6,26.8,"thymus: 26.8 nTPM (manageable, limit 5); lymph node: 15.6 nTPM (protected, limit 3); bone marrow: 11.7 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 3); spleen: 5.5 nTPM (manageable, limit 5); esophagus: 4.5 nTPM (protected, limit 3); colon: 4.2 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169679,BUB1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 71.5328% (minimum 75%, Missing); lymph node: 65.3333% (minimum 70%, Missing); thymus: 52.3132% (minimum 65%, Missing)",-0.126868,-0.0466667,-0.0346715,0,80,unavailable,11.7,15.6,26.8,"thymus: 26.8 nTPM (manageable, limit 5); lymph node: 15.6 nTPM (protected, limit 3); bone marrow: 11.7 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 3); spleen: 5.5 nTPM (manageable, limit 5); esophagus: 4.5 nTPM (protected, limit 3); colon: 4.2 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169679,BUB1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 71.5328% (minimum 75%, Baseline (adaptation disabled)); lymph node: 65.3333% (minimum 70%, Baseline (adaptation disabled)); thymus: 52.3132% (minimum 65%, Baseline (adaptation disabled))",-0.126868,-0.0466667,-0.0346715,0,80,unavailable,11.7,15.6,26.8,"thymus: 26.8 nTPM (manageable, limit 5); lymph node: 15.6 nTPM (protected, limit 3); bone marrow: 11.7 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 3); spleen: 5.5 nTPM (manageable, limit 5); esophagus: 4.5 nTPM (protected, limit 3); colon: 4.2 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169679,BUB1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.9474% (minimum 90%, Approved); adrenal gland: 61.2245% (minimum 98%, Approved); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 98%, Approved); cerebellum: 81.0811% (minimum 98%, Approved); cerebral cortex: 78.9474% (minimum 99%, Missing); choroid plexus: 73.1707% (minimum 99%, Missing); colon: 43.4783% (minimum 95%, Approved); duodenum: 39.4737% (minimum 98%, Approved); esophagus: 66.6667% (minimum 95%, Approved); heart muscle: 71.4286% (minimum 98%, Approved); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 81.0811% (minimum 99%, Missing); kidney: 90.9091% (minimum 98%, Approved); liver: 90.9091% (minimum 98%, Approved); lung: 85.7143% (minimum 98%, Approved); lymph node: 81.0811% (minimum 95%, Approved); midbrain: 81.0811% (minimum 99%, Missing); pancreas: 62.5000% (minimum 98%, Approved); parathyroid gland: 90.9091% (minimum 95%, Approved); pituitary gland: 93.7500% (minimum 99%, Missing); rectum: 42.2535% (minimum 95%, Approved); retina: 54.5455% (minimum 99%, Missing); salivary gland: 81.0811% (minimum 95%, Approved); skeletal muscle: 44.1176% (minimum 98%, Approved); skin: 83.3333% (minimum 90%, Approved); small intestine: 56.6038% (minimum 98%, Approved); smooth muscle: 60.0000% (minimum 99%, Missing); spinal cord: 83.3333% (minimum 99%, Missing); stomach: 52.6316% (minimum 95%, Approved); thymus: 81.0811% (minimum 95%, Missing); tongue: 85.7143% (minimum 97%, Missing); urinary bladder: 63.8298% (minimum 95%, Approved)",-0.139189,-0.527465,-0.585263,0,2,partial,4.6,4.1,0.8,"duodenum: 4.6 nTPM (vital, limit 2); rectum: 4.1 nTPM (protected, limit 4); skeletal muscle: 3.8 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 2); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169684,CHRNA5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.2245% (minimum 70%, Approved); choroid plexus: 73.1707% (minimum 75%, Missing); colon: 43.4783% (minimum 65%, Approved); duodenum: 39.4737% (minimum 70%, Approved); pancreas: 62.5000% (minimum 70%, Approved); rectum: 42.2535% (minimum 65%, Approved); retina: 54.5455% (minimum 75%, Missing); skeletal muscle: 44.1176% (minimum 70%, Approved); small intestine: 56.6038% (minimum 70%, Approved); smooth muscle: 60.0000% (minimum 75%, Missing); stomach: 52.6316% (minimum 65%, Approved); urinary bladder: 63.8298% (minimum 65%, Approved)",0.160811,-0.227465,-0.305263,0,2,partial,4.6,4.1,0.8,"duodenum: 4.6 nTPM (vital, limit 2); rectum: 4.1 nTPM (protected, limit 4); skeletal muscle: 3.8 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 2); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169684,CHRNA5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.2245% (minimum 70%, Approved); choroid plexus: 73.1707% (minimum 75%, Missing); colon: 43.4783% (minimum 65%, Approved); duodenum: 39.4737% (minimum 70%, Approved); pancreas: 62.5000% (minimum 70%, Approved); rectum: 42.2535% (minimum 65%, Approved); retina: 54.5455% (minimum 75%, Missing); skeletal muscle: 44.1176% (minimum 70%, Approved); small intestine: 56.6038% (minimum 70%, Approved); smooth muscle: 60.0000% (minimum 75%, Missing); stomach: 52.6316% (minimum 65%, Approved); urinary bladder: 63.8298% (minimum 65%, Approved)",0.160811,-0.227465,-0.305263,0,2,partial,4.6,4.1,0.8,"duodenum: 4.6 nTPM (vital, limit 2); rectum: 4.1 nTPM (protected, limit 4); skeletal muscle: 3.8 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 2); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169684,CHRNA5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.2245% (minimum 70%, Approved); choroid plexus: 73.1707% (minimum 75%, Missing); colon: 43.4783% (minimum 65%, Approved); duodenum: 39.4737% (minimum 70%, Approved); pancreas: 62.5000% (minimum 70%, Approved); rectum: 42.2535% (minimum 65%, Approved); retina: 54.5455% (minimum 75%, Missing); skeletal muscle: 44.1176% (minimum 70%, Approved); small intestine: 56.6038% (minimum 70%, Approved); smooth muscle: 60.0000% (minimum 75%, Missing); stomach: 52.6316% (minimum 65%, Approved); urinary bladder: 63.8298% (minimum 65%, Approved)",0.160811,-0.227465,-0.305263,0,2,partial,4.6,4.1,0.8,"duodenum: 4.6 nTPM (vital, limit 2); rectum: 4.1 nTPM (protected, limit 4); skeletal muscle: 3.8 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 2); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169684,CHRNA5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.2245% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.1707% (minimum 75%, Baseline (adaptation disabled)); colon: 43.4783% (minimum 70%, Baseline (adaptation disabled)); duodenum: 39.4737% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.5000% (minimum 75%, Baseline (adaptation disabled)); rectum: 42.2535% (minimum 70%, Baseline (adaptation disabled)); retina: 54.5455% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 44.1176% (minimum 75%, Baseline (adaptation disabled)); small intestine: 56.6038% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); stomach: 52.6316% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.8298% (minimum 70%, Baseline (adaptation disabled))",0.139474,-0.277465,-0.355263,0,2,partial,4.6,4.1,0.8,"duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 3); colon: 3.9 nTPM (protected, limit 3); skeletal muscle: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169684,CHRNA5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.01,0,7,partial,0,0,0,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169717,ACTRT2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,7,partial,0,0,0,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169717,ACTRT2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,7,partial,0,0,0,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169717,ACTRT2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,7,partial,0,0,0,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169717,ACTRT2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,7,partial,0,0,0,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169717,ACTRT2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 85.1852% (minimum 99%, Missing); amygdala: 52.2727% (minimum 99%, Missing); basal ganglia: 55.4217% (minimum 99%, Missing); cerebellum: 48.9362% (minimum 99%, Missing); cerebral cortex: 27.2189% (minimum 99%, Missing); choroid plexus: 77.9661% (minimum 99%, Missing); colon: 71.8750% (minimum 97%, Missing); duodenum: 95.8333% (minimum 99%, Missing); esophagus: 70.7692% (minimum 80%, Enhanced); heart muscle: 63.0137% (minimum 99%, Missing); hippocampal formation: 50.5495% (minimum 99%, Missing); hypothalamus: 51.1111% (minimum 99%, Missing); kidney: 67.6471% (minimum 99%, Missing); lung: 93.8776% (minimum 95%, Enhanced); lymph node: 95.8333% (minimum 97%, Missing); midbrain: 60.5263% (minimum 99%, Missing); pancreas: 88.4615% (minimum 99%, Missing); parathyroid gland: 90.1961% (minimum 97%, Missing); pituitary gland: 73.0159% (minimum 99%, Missing); retina: 30.0654% (minimum 99%, Missing); salivary gland: 95.8333% (minimum 97%, Missing); small intestine: 90.1961% (minimum 99%, Missing); smooth muscle: 68.6567% (minimum 95%, Enhanced); spinal cord: 65.7143% (minimum 99%, Missing); stomach: 86.7925% (minimum 97%, Missing); thyroid gland: 85.1852% (minimum 95%, Missing); tongue: 86.7925% (minimum 97%, Missing); urinary bladder: 67.6471% (minimum 97%, Missing)",-0.0981481,-0.293529,-0.717811,0,9,partial,12.3,2.2,1.6,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169760,NLGN1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 52.2727% (minimum 75%, Missing); basal ganglia: 55.4217% (minimum 75%, Missing); cerebellum: 48.9362% (minimum 75%, Missing); cerebral cortex: 27.2189% (minimum 75%, Missing); heart muscle: 63.0137% (minimum 75%, Missing); hippocampal formation: 50.5495% (minimum 75%, Missing); hypothalamus: 51.1111% (minimum 75%, Missing); kidney: 67.6471% (minimum 75%, Missing); midbrain: 60.5263% (minimum 75%, Missing); pituitary gland: 73.0159% (minimum 75%, Missing); retina: 30.0654% (minimum 75%, Missing); spinal cord: 65.7143% (minimum 75%, Missing); urinary bladder: 67.6471% (minimum 70%, Missing)",0.201852,-0.0235294,-0.477811,0,9,partial,12.3,2.2,1.6,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169760,NLGN1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 52.2727% (minimum 75%, Missing); basal ganglia: 55.4217% (minimum 75%, Missing); cerebellum: 48.9362% (minimum 75%, Missing); cerebral cortex: 27.2189% (minimum 75%, Missing); heart muscle: 63.0137% (minimum 75%, Missing); hippocampal formation: 50.5495% (minimum 75%, Missing); hypothalamus: 51.1111% (minimum 75%, Missing); kidney: 67.6471% (minimum 75%, Missing); midbrain: 60.5263% (minimum 75%, Missing); pituitary gland: 73.0159% (minimum 75%, Missing); retina: 30.0654% (minimum 75%, Missing); spinal cord: 65.7143% (minimum 75%, Missing); urinary bladder: 67.6471% (minimum 70%, Missing)",0.201852,-0.0235294,-0.477811,0,9,partial,12.3,2.2,1.6,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169760,NLGN1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 52.2727% (minimum 75%, Missing); basal ganglia: 55.4217% (minimum 75%, Missing); cerebellum: 48.9362% (minimum 75%, Missing); cerebral cortex: 27.2189% (minimum 75%, Missing); heart muscle: 63.0137% (minimum 75%, Missing); hippocampal formation: 50.5495% (minimum 75%, Missing); hypothalamus: 51.1111% (minimum 75%, Missing); kidney: 67.6471% (minimum 75%, Missing); midbrain: 60.5263% (minimum 75%, Missing); pituitary gland: 73.0159% (minimum 75%, Missing); retina: 30.0654% (minimum 75%, Missing); spinal cord: 65.7143% (minimum 75%, Missing); urinary bladder: 67.6471% (minimum 70%, Missing)",0.201852,-0.0235294,-0.477811,0,9,partial,12.3,2.2,1.6,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169760,NLGN1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 52.2727% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.4217% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.9362% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 27.2189% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 63.0137% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.5495% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 51.1111% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.6471% (minimum 75%, Baseline (adaptation disabled)); midbrain: 60.5263% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 73.0159% (minimum 75%, Baseline (adaptation disabled)); retina: 30.0654% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.6567% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.7143% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 67.6471% (minimum 70%, Baseline (adaptation disabled))",0.0919355,-0.0235294,-0.477811,0,9,partial,12.3,2.2,1.6,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169760,NLGN1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 97.3333% (minimum 99%, Missing); hippocampal formation: 98.6486% (minimum 99%, Missing); retina: 97.3333% (minimum 99%, Missing)",0.05,0.0164865,-0.0166667,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169777,TAS2R1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.286486,0.223333,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169777,TAS2R1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.286486,0.223333,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169777,TAS2R1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.286486,0.223333,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169777,TAS2R1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.286486,0.223333,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169777,TAS2R1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169800,RBMY1F,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169800,RBMY1F,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169800,RBMY1F,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169800,RBMY1F,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169800,RBMY1F,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 78.4314% (minimum 95%, Missing); adrenal gland: 88.8889% (minimum 99%, Missing); amygdala: 39.6040% (minimum 99%, Missing); basal ganglia: 41.6667% (minimum 99%, Missing); cerebellum: 25.0000% (minimum 99%, Missing); cerebral cortex: 33.8983% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 75.4717% (minimum 97%, Missing); duodenum: 93.0233% (minimum 99%, Missing); esophagus: 86.9565% (minimum 97%, Missing); heart muscle: 76.9231% (minimum 99%, Missing); hippocampal formation: 33.3333% (minimum 99%, Missing); hypothalamus: 43.0108% (minimum 99%, Missing); kidney: 81.6327% (minimum 99%, Missing); liver: 93.0233% (minimum 99%, Missing); lung: 85.1064% (minimum 99%, Missing); lymph node: 93.0233% (minimum 97%, Missing); midbrain: 37.3832% (minimum 99%, Missing); pancreas: 75.4717% (minimum 99%, Missing); parathyroid gland: 78.4314% (minimum 97%, Missing); pituitary gland: 72.7273% (minimum 99%, Missing); rectum: 90.9091% (minimum 97%, Missing); retina: 72.7273% (minimum 99%, Missing); salivary gland: 85.1064% (minimum 97%, Missing); skeletal muscle: 80.0000% (minimum 99%, Missing); skin: 61.5385% (minimum 95%, Missing); small intestine: 83.3333% (minimum 99%, Missing); smooth muscle: 86.9565% (minimum 99%, Missing); spinal cord: 28.9855% (minimum 99%, Missing); spleen: 86.9565% (minimum 95%, Missing); stomach: 83.3333% (minimum 97%, Missing); thymus: 93.0233% (minimum 95%, Missing); thyroid gland: 80.0000% (minimum 95%, Missing); tongue: 95.2381% (minimum 97%, Missing); urinary bladder: 83.3333% (minimum 97%, Missing)",-0.334615,-0.215283,-0.74,0,80,unavailable,12,1.3,2.5,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169918,OTUD7A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 39.6040% (minimum 75%, Missing); basal ganglia: 41.6667% (minimum 75%, Missing); cerebellum: 25.0000% (minimum 75%, Missing); cerebral cortex: 33.8983% (minimum 75%, Missing); hippocampal formation: 33.3333% (minimum 75%, Missing); hypothalamus: 43.0108% (minimum 75%, Missing); midbrain: 37.3832% (minimum 75%, Missing); pituitary gland: 72.7273% (minimum 75%, Missing); retina: 72.7273% (minimum 75%, Missing); skin: 61.5385% (minimum 65%, Missing); spinal cord: 28.9855% (minimum 75%, Missing)",-0.0346154,0.054717,-0.5,0,80,unavailable,12,1.3,2.5,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169918,OTUD7A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 39.6040% (minimum 75%, Missing); basal ganglia: 41.6667% (minimum 75%, Missing); cerebellum: 25.0000% (minimum 75%, Missing); cerebral cortex: 33.8983% (minimum 75%, Missing); hippocampal formation: 33.3333% (minimum 75%, Missing); hypothalamus: 43.0108% (minimum 75%, Missing); midbrain: 37.3832% (minimum 75%, Missing); pituitary gland: 72.7273% (minimum 75%, Missing); retina: 72.7273% (minimum 75%, Missing); skin: 61.5385% (minimum 65%, Missing); spinal cord: 28.9855% (minimum 75%, Missing)",-0.0346154,0.054717,-0.5,0,80,unavailable,12,1.3,2.5,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169918,OTUD7A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 39.6040% (minimum 75%, Missing); basal ganglia: 41.6667% (minimum 75%, Missing); cerebellum: 25.0000% (minimum 75%, Missing); cerebral cortex: 33.8983% (minimum 75%, Missing); hippocampal formation: 33.3333% (minimum 75%, Missing); hypothalamus: 43.0108% (minimum 75%, Missing); midbrain: 37.3832% (minimum 75%, Missing); pituitary gland: 72.7273% (minimum 75%, Missing); retina: 72.7273% (minimum 75%, Missing); skin: 61.5385% (minimum 65%, Missing); spinal cord: 28.9855% (minimum 75%, Missing)",-0.0346154,0.054717,-0.5,0,80,unavailable,12,1.3,2.5,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169918,OTUD7A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 39.6040% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 41.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 25.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 33.8983% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 33.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 43.0108% (minimum 75%, Baseline (adaptation disabled)); midbrain: 37.3832% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 72.7273% (minimum 75%, Baseline (adaptation disabled)); retina: 72.7273% (minimum 75%, Baseline (adaptation disabled)); skin: 61.5385% (minimum 65%, Baseline (adaptation disabled)); spinal cord: 28.9855% (minimum 75%, Baseline (adaptation disabled))",-0.0346154,0.054717,-0.5,0,80,unavailable,12,1.3,2.5,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169918,OTUD7A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.5577% (minimum 99%, Missing); cerebellum: 98.0861% (minimum 99%, Missing); cerebral cortex: 98.0861% (minimum 99%, Missing); hippocampal formation: 98.5577% (minimum 99%, Missing); hypothalamus: 97.1564% (minimum 99%, Missing)",0.05,0.03,-0.018436,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169953,HSFY2,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.221564,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169953,HSFY2,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.221564,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169953,HSFY2,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.221564,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169953,HSFY2,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.221564,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000169953,HSFY2,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Uncertain); adrenal gland: 69.4444% (minimum 99%, Missing); amygdala: 73.5294% (minimum 99%, Missing); basal ganglia: 72.4638% (minimum 99%, Missing); bone marrow: 76.9231% (minimum 99%, Missing); cerebellum: 59.5238% (minimum 99%, Missing); cerebral cortex: 63.2911% (minimum 99%, Missing); choroid plexus: 78.1250% (minimum 99%, Missing); colon: 69.4444% (minimum 97%, Missing); duodenum: 81.9672% (minimum 99%, Missing); esophagus: 72.4638% (minimum 97%, Missing); heart muscle: 69.4444% (minimum 99%, Missing); hippocampal formation: 73.5294% (minimum 99%, Missing); hypothalamus: 73.5294% (minimum 99%, Missing); kidney: 61.7284% (minimum 99%, Missing); liver: 71.4286% (minimum 99%, Missing); lung: 70.4225% (minimum 99%, Missing); lymph node: 73.5294% (minimum 97%, Missing); midbrain: 73.5294% (minimum 99%, Missing); pancreas: 50.5051% (minimum 99%, Missing); parathyroid gland: 39.0625% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 73.5294% (minimum 97%, Missing); retina: 56.8182% (minimum 99%, Missing); salivary gland: 67.5676% (minimum 97%, Missing); skeletal muscle: 57.4713% (minimum 99%, Missing); skin: 61.7284% (minimum 95%, Missing); small intestine: 74.6269% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 69.4444% (minimum 99%, Missing); spleen: 69.4444% (minimum 95%, Missing); stomach: 68.4932% (minimum 97%, Missing); thymus: 71.4286% (minimum 95%, Missing); thyroid gland: 62.5000% (minimum 95%, Missing); tongue: 54.9451% (minimum 97%, Missing); urinary bladder: 71.4286% (minimum 97%, Missing)",-0.332716,-0.579375,-0.484949,0,0,routine_complete,4.9,7.8,3.1,"parathyroid gland: 7.8 nTPM (protected, limit 2); pancreas: 4.9 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170100,ZNF778,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.4444% (minimum 75%, Missing); amygdala: 73.5294% (minimum 75%, Missing); basal ganglia: 72.4638% (minimum 75%, Missing); cerebellum: 59.5238% (minimum 75%, Missing); cerebral cortex: 63.2911% (minimum 75%, Missing); colon: 69.4444% (minimum 70%, Missing); heart muscle: 69.4444% (minimum 75%, Missing); hippocampal formation: 73.5294% (minimum 75%, Missing); hypothalamus: 73.5294% (minimum 75%, Missing); kidney: 61.7284% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lung: 70.4225% (minimum 75%, Missing); midbrain: 73.5294% (minimum 75%, Missing); pancreas: 50.5051% (minimum 75%, Missing); parathyroid gland: 39.0625% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 56.8182% (minimum 75%, Missing); salivary gland: 67.5676% (minimum 70%, Missing); skeletal muscle: 57.4713% (minimum 75%, Missing); skin: 61.7284% (minimum 65%, Missing); small intestine: 74.6269% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 69.4444% (minimum 75%, Missing); stomach: 68.4932% (minimum 70%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 54.9451% (minimum 70%, Missing)",-0.032716,-0.309375,-0.244949,0,0,routine_complete,4.9,7.8,3.1,"parathyroid gland: 7.8 nTPM (protected, limit 2); pancreas: 4.9 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170100,ZNF778,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.4444% (minimum 75%, Missing); amygdala: 73.5294% (minimum 75%, Missing); basal ganglia: 72.4638% (minimum 75%, Missing); cerebellum: 59.5238% (minimum 75%, Missing); cerebral cortex: 63.2911% (minimum 75%, Missing); colon: 69.4444% (minimum 70%, Missing); heart muscle: 69.4444% (minimum 75%, Missing); hippocampal formation: 73.5294% (minimum 75%, Missing); hypothalamus: 73.5294% (minimum 75%, Missing); kidney: 61.7284% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lung: 70.4225% (minimum 75%, Missing); midbrain: 73.5294% (minimum 75%, Missing); pancreas: 50.5051% (minimum 75%, Missing); parathyroid gland: 39.0625% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 56.8182% (minimum 75%, Missing); salivary gland: 67.5676% (minimum 70%, Missing); skeletal muscle: 57.4713% (minimum 75%, Missing); skin: 61.7284% (minimum 65%, Missing); small intestine: 74.6269% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 69.4444% (minimum 75%, Missing); stomach: 68.4932% (minimum 70%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 54.9451% (minimum 70%, Missing)",-0.032716,-0.309375,-0.244949,0,0,routine_complete,4.9,7.8,3.1,"parathyroid gland: 7.8 nTPM (protected, limit 3); pancreas: 4.9 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 3); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170100,ZNF778,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.4444% (minimum 75%, Missing); amygdala: 73.5294% (minimum 75%, Missing); basal ganglia: 72.4638% (minimum 75%, Missing); cerebellum: 59.5238% (minimum 75%, Missing); cerebral cortex: 63.2911% (minimum 75%, Missing); colon: 69.4444% (minimum 70%, Missing); heart muscle: 69.4444% (minimum 75%, Missing); hippocampal formation: 73.5294% (minimum 75%, Missing); hypothalamus: 73.5294% (minimum 75%, Missing); kidney: 61.7284% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lung: 70.4225% (minimum 75%, Missing); midbrain: 73.5294% (minimum 75%, Missing); pancreas: 50.5051% (minimum 75%, Missing); parathyroid gland: 39.0625% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 56.8182% (minimum 75%, Missing); salivary gland: 67.5676% (minimum 70%, Missing); skeletal muscle: 57.4713% (minimum 75%, Missing); skin: 61.7284% (minimum 65%, Missing); small intestine: 74.6269% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 69.4444% (minimum 75%, Missing); stomach: 68.4932% (minimum 70%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 54.9451% (minimum 70%, Missing)",-0.032716,-0.309375,-0.244949,0,0,routine_complete,4.9,7.8,3.1,"parathyroid gland: 7.8 nTPM (protected, limit 3); pancreas: 4.9 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 3); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170100,ZNF778,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.4444% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.5294% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 72.4638% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 59.5238% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.2911% (minimum 75%, Baseline (adaptation disabled)); colon: 69.4444% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.4444% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.5294% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.5294% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.7284% (minimum 75%, Baseline (adaptation disabled)); liver: 71.4286% (minimum 75%, Baseline (adaptation disabled)); lung: 70.4225% (minimum 75%, Baseline (adaptation disabled)); midbrain: 73.5294% (minimum 75%, Baseline (adaptation disabled)); pancreas: 50.5051% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 39.0625% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 56.8182% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 67.5676% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 57.4713% (minimum 75%, Baseline (adaptation disabled)); skin: 61.7284% (minimum 65%, Baseline (adaptation disabled)); small intestine: 74.6269% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.4444% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.4932% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 62.5000% (minimum 65%, Baseline (adaptation disabled)); tongue: 54.9451% (minimum 70%, Baseline (adaptation disabled))",-0.032716,-0.309375,-0.244949,0,0,routine_complete,4.9,7.8,3.1,"parathyroid gland: 7.8 nTPM (protected, limit 3); pancreas: 4.9 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 3); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170100,ZNF778,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Missing); adrenal gland: 85.2174% (minimum 95%, Enhanced); amygdala: 98.0000% (minimum 99%, Missing); basal ganglia: 97.0297% (minimum 99%, Missing); bone marrow: 55.0562% (minimum 95%, Enhanced); cerebellum: 62.4204% (minimum 99%, Missing); cerebral cortex: 73.1343% (minimum 95%, Enhanced); choroid plexus: 96.0784% (minimum 99%, Missing); duodenum: 91.5888% (minimum 95%, Enhanced); heart muscle: 88.2883% (minimum 95%, Enhanced); hippocampal formation: 96.0784% (minimum 99%, Missing); hypothalamus: 98.0000% (minimum 99%, Missing); kidney: 93.3333% (minimum 99%, Missing); liver: 89.9083% (minimum 95%, Enhanced); lung: 83.7607% (minimum 95%, Enhanced); midbrain: 98.0000% (minimum 99%, Missing); pancreas: 79.0323% (minimum 95%, Enhanced); pituitary gland: 86.7257% (minimum 99%, Missing); retina: 43.9462% (minimum 99%, Missing); skeletal muscle: 90.7407% (minimum 95%, Enhanced); small intestine: 89.9083% (minimum 95%, Enhanced); smooth muscle: 83.7607% (minimum 95%, Enhanced); spinal cord: 94.2308% (minimum 99%, Missing); stomach: 84.4828% (minimum 97%, Missing); thymus: 69.5035% (minimum 95%, Missing); tongue: 83.0508% (minimum 97%, Missing); urinary bladder: 85.9649% (minimum 97%, Missing)",-0.254965,-0.139492,-0.550538,0,3,partial,12.5,2.2,4.3,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 6); cerebellum: 5.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170160,CCDC144A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.0562% (minimum 60%, Enhanced); cerebellum: 62.4204% (minimum 75%, Missing); retina: 43.9462% (minimum 75%, Missing)",0.0450355,0.130508,-0.310538,0,3,partial,12.5,2.2,4.3,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 6); cerebellum: 5.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170160,CCDC144A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.0562% (minimum 60%, Enhanced); cerebellum: 62.4204% (minimum 75%, Missing); retina: 43.9462% (minimum 75%, Missing)",0.0450355,0.130508,-0.310538,0,3,partial,12.5,2.2,4.3,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 6); cerebellum: 5.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170160,CCDC144A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.0562% (minimum 60%, Enhanced); cerebellum: 62.4204% (minimum 75%, Missing); retina: 43.9462% (minimum 75%, Missing)",0.0450355,0.130508,-0.310538,0,3,partial,12.5,2.2,4.3,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 6); cerebellum: 5.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170160,CCDC144A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.0562% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.4204% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.1343% (minimum 75%, Baseline (adaptation disabled)); retina: 43.9462% (minimum 75%, Baseline (adaptation disabled))",0.0450355,0.116667,-0.310538,0,3,partial,12.5,2.2,4.3,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); cerebral cortex: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170160,CCDC144A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Missing); adrenal gland: 88.2353% (minimum 99%, Missing); amygdala: 93.7500% (minimum 99%, Missing); basal ganglia: 88.2353% (minimum 99%, Missing); cerebellum: 88.2353% (minimum 99%, Missing); cerebral cortex: 88.2353% (minimum 99%, Missing); colon: 93.7500% (minimum 97%, Missing); esophagus: 93.7500% (minimum 97%, Missing); heart muscle: 93.7500% (minimum 99%, Missing); hippocampal formation: 93.7500% (minimum 99%, Missing); hypothalamus: 88.2353% (minimum 99%, Missing); kidney: 71.4286% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 88.2353% (minimum 99%, Missing); midbrain: 93.7500% (minimum 99%, Missing); pituitary gland: 78.9474% (minimum 99%, Missing); salivary gland: 93.7500% (minimum 97%, Missing); skeletal muscle: 93.7500% (minimum 99%, Missing); skin: 93.7500% (minimum 95%, Missing); small intestine: 93.7500% (minimum 99%, Missing); spinal cord: 93.7500% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); thyroid gland: 88.2353% (minimum 95%, Missing); urinary bladder: 93.7500% (minimum 97%, Missing)",-0.116667,-0.0325,-0.275714,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170236,USP50,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 71.4286% (minimum 75%, Missing)",0.183333,0.2375,-0.0357143,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170236,USP50,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 71.4286% (minimum 75%, Missing)",0.183333,0.2375,-0.0357143,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170236,USP50,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 71.4286% (minimum 75%, Missing)",0.183333,0.2375,-0.0357143,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170236,USP50,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 71.4286% (minimum 75%, Baseline (adaptation disabled))",0.183333,0.2375,-0.0357143,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170236,USP50,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.7143% (minimum 90%, Approved); adrenal gland: 81.8182% (minimum 98%, Approved); amygdala: 77.1429% (minimum 99%, Missing); basal ganglia: 71.0526% (minimum 99%, Missing); bone marrow: 94.7368% (minimum 98%, Approved); cerebellum: 84.3750% (minimum 98%, Approved); cerebral cortex: 72.9730% (minimum 99%, Missing); choroid plexus: 60.0000% (minimum 99%, Missing); colon: 85.7143% (minimum 95%, Approved); duodenum: 93.1034% (minimum 98%, Approved); esophagus: 84.3750% (minimum 95%, Approved); heart muscle: 79.4118% (minimum 98%, Approved); hippocampal formation: 77.1429% (minimum 99%, Missing); hypothalamus: 72.9730% (minimum 99%, Missing); kidney: 73.9726% (minimum 99%, Missing); liver: 88.5246% (minimum 98%, Approved); lung: 84.3750% (minimum 99%, Missing); lymph node: 88.5246% (minimum 95%, Approved); midbrain: 81.8182% (minimum 99%, Missing); pancreas: 71.0526% (minimum 98%, Approved); parathyroid gland: 75.0000% (minimum 95%, Approved); pituitary gland: 69.2308% (minimum 99%, Missing); rectum: 90.0000% (minimum 95%, Approved); retina: 16.1194% (minimum 99%, Missing); salivary gland: 88.5246% (minimum 95%, Approved); skeletal muscle: 81.8182% (minimum 98%, Approved); small intestine: 88.5246% (minimum 98%, Approved); smooth muscle: 90.0000% (minimum 98%, Approved); spinal cord: 77.1429% (minimum 99%, Missing); spleen: 88.5246% (minimum 90%, Approved); stomach: 68.3544% (minimum 97%, Missing); thymus: 78.2609% (minimum 95%, Missing); thyroid gland: 60.6742% (minimum 90%, Approved); tongue: 96.4286% (minimum 97%, Missing); urinary bladder: 84.3750% (minimum 95%, Approved)",-0.293258,-0.286456,-0.828806,0,4,partial,28.1,2.5,3.5,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170264,FAM161A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.0526% (minimum 75%, Missing); cerebral cortex: 72.9730% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); hypothalamus: 72.9730% (minimum 75%, Missing); kidney: 73.9726% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); retina: 16.1194% (minimum 75%, Missing); stomach: 68.3544% (minimum 70%, Missing)",0.00674157,-0.0164557,-0.588806,0,4,partial,28.1,2.5,3.5,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170264,FAM161A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.0526% (minimum 75%, Missing); cerebral cortex: 72.9730% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); hypothalamus: 72.9730% (minimum 75%, Missing); kidney: 73.9726% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); retina: 16.1194% (minimum 75%, Missing); stomach: 68.3544% (minimum 70%, Missing)",0.00674157,-0.0164557,-0.588806,0,4,partial,28.1,2.5,3.5,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170264,FAM161A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.0526% (minimum 75%, Missing); cerebral cortex: 72.9730% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); hypothalamus: 72.9730% (minimum 75%, Missing); kidney: 73.9726% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); retina: 16.1194% (minimum 75%, Missing); stomach: 68.3544% (minimum 70%, Missing)",0.00674157,-0.0164557,-0.588806,0,4,partial,28.1,2.5,3.5,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170264,FAM161A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.0526% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.9730% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.9730% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.9726% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.0526% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 69.2308% (minimum 75%, Baseline (adaptation disabled)); retina: 16.1194% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.3544% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 60.6742% (minimum 65%, Baseline (adaptation disabled))",-0.0432584,-0.0164557,-0.588806,0,4,partial,28.1,2.5,3.5,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170264,FAM161A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 13.3333% (minimum 99%, Missing)",0.05,0.03,-0.856667,0,80,unavailable,1.3,0,0,"retina: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170279,C7orf33,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 13.3333% (minimum 75%, Missing)",0.35,0.3,-0.616667,0,80,unavailable,1.3,0,0,"retina: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170279,C7orf33,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 13.3333% (minimum 75%, Missing)",0.35,0.3,-0.616667,0,80,unavailable,1.3,0,0,"retina: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170279,C7orf33,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 13.3333% (minimum 75%, Missing)",0.35,0.3,-0.616667,0,80,unavailable,1.3,0,0,"retina: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170279,C7orf33,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 13.3333% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.616667,0,80,unavailable,1.3,0,0,"retina: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170279,C7orf33,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.9060% (minimum 99%, Missing); basal ganglia: 96.2938% (minimum 99%, Missing); choroid plexus: 93.6435% (minimum 99%, Missing); heart muscle: 87.7764% (minimum 95%, Enhanced); hippocampal formation: 96.4238% (minimum 99%, Missing); hypothalamus: 95.9060% (minimum 99%, Missing); kidney: 90.8455% (minimum 95%, Enhanced); midbrain: 96.0349% (minimum 99%, Missing); pituitary gland: 92.0747% (minimum 99%, Missing); retina: 95.7775% (minimum 99%, Missing); skeletal muscle: 86.5536% (minimum 95%, Enhanced); spinal cord: 97.1448% (minimum 99%, Missing); tongue: 88.5927% (minimum 97%, Missing)",0.029438,-0.0840732,-0.084464,0,2,partial,22.2,18.4,7,"skeletal muscle: 22.2 nTPM (vital, limit 6); heart muscle: 19.9 nTPM (vital, limit 6); tongue: 18.4 nTPM (protected, limit 2); kidney: 14.4 nTPM (vital, limit 6); pituitary gland: 12.3 nTPM (vital, limit 1); choroid plexus: 9.7 nTPM (vital, limit 1); adrenal gland: 6.9 nTPM (vital, limit 6); small intestine: 6.9 nTPM (vital, limit 6); duodenum: 6.3 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170469,SPATA24,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329438,0.185927,0.170747,0,2,partial,22.2,18.4,7,"skeletal muscle: 22.2 nTPM (vital, limit 6); heart muscle: 19.9 nTPM (vital, limit 6); tongue: 18.4 nTPM (protected, limit 2); kidney: 14.4 nTPM (vital, limit 6); pituitary gland: 12.3 nTPM (vital, limit 1); choroid plexus: 9.7 nTPM (vital, limit 1); adrenal gland: 6.9 nTPM (vital, limit 6); small intestine: 6.9 nTPM (vital, limit 6); duodenum: 6.3 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170469,SPATA24,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329438,0.185927,0.170747,0,2,partial,22.2,18.4,7,"skeletal muscle: 22.2 nTPM (vital, limit 6); heart muscle: 19.9 nTPM (vital, limit 6); tongue: 18.4 nTPM (protected, limit 3); kidney: 14.4 nTPM (vital, limit 6); pituitary gland: 12.3 nTPM (vital, limit 1); choroid plexus: 9.7 nTPM (vital, limit 1); adrenal gland: 6.9 nTPM (vital, limit 6); small intestine: 6.9 nTPM (vital, limit 6); duodenum: 6.3 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170469,SPATA24,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329438,0.185927,0.170747,0,2,partial,22.2,18.4,7,"skeletal muscle: 22.2 nTPM (vital, limit 6); heart muscle: 19.9 nTPM (vital, limit 6); tongue: 18.4 nTPM (protected, limit 3); kidney: 14.4 nTPM (vital, limit 6); pituitary gland: 12.3 nTPM (vital, limit 1); choroid plexus: 9.7 nTPM (vital, limit 1); adrenal gland: 6.9 nTPM (vital, limit 6); small intestine: 6.9 nTPM (vital, limit 6); duodenum: 6.3 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170469,SPATA24,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.303302,0.185927,0.115536,0,2,partial,22.2,18.4,7,"skeletal muscle: 22.2 nTPM (vital, limit 1); heart muscle: 19.9 nTPM (vital, limit 1); tongue: 18.4 nTPM (protected, limit 3); kidney: 14.4 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); parathyroid gland: 12 nTPM (protected, limit 3); choroid plexus: 9.7 nTPM (vital, limit 1); thyroid gland: 7 nTPM (manageable, limit 5); lymph node: 7 nTPM (protected, limit 3); adrenal gland: 6.9 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); retina: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); spinal cord: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170469,SPATA24,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 93.1174% (minimum 95%, Enhanced); skin: 69.2771% (minimum 95%, Missing); small intestine: 91.6335% (minimum 95%, Enhanced)",-0.257229,0.03,-0.0336653,0,6,partial,2.1,2.8,10.2,"skin: 10.2 nTPM (manageable, limit 5)",,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; hair / cells in cuticle; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170486,KRT72,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0427711,0.3,0.25,0,6,partial,2.1,2.8,10.2,"skin: 10.2 nTPM (manageable, limit 5)",,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; hair / cells in cuticle; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170486,KRT72,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0427711,0.3,0.25,0,6,partial,2.1,2.8,10.2,"skin: 10.2 nTPM (manageable, limit 5)",,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; hair / cells in cuticle; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170486,KRT72,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0427711,0.3,0.25,0,6,partial,2.1,2.8,10.2,"skin: 10.2 nTPM (manageable, limit 5)",,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; hair / cells in cuticle; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170486,KRT72,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0427711,0.191473,0.166335,0,6,partial,2.1,2.8,10.2,"skin: 10.2 nTPM (manageable, limit 5); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; hair / cells in cuticle; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170486,KRT72,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.0936% (minimum 99%, Missing); hypothalamus: 98.2639% (minimum 99%, Missing)",0.0495585,0.0295585,-0.00906412,0,4,partial,4.4,2.1,1.4,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170498,KISS1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349558,0.299558,0.230936,0,4,partial,4.4,2.1,1.4,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170498,KISS1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349558,0.299558,0.230936,0,4,partial,4.4,2.1,1.4,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170498,KISS1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349558,0.299558,0.230936,0,4,partial,4.4,2.1,1.4,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170498,KISS1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343854,0.29081,0.230936,0,4,partial,4.4,2.1,1.4,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170498,KISS1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.0488024,0.03,0.01,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170516,COX7B2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348802,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170516,COX7B2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348802,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170516,COX7B2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348802,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170516,COX7B2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348802,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170516,COX7B2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170613,GARIN3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170613,GARIN3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170613,GARIN3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170613,GARIN3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170613,GARIN3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.7828% (minimum 98%, Approved)",0.0183476,0.0204301,-0.0121716,0,2,partial,6,5.5,5.9,"bone marrow: 6 nTPM (vital, limit 2); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170627,GTSF1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.318348,0.299446,0.245039,0,2,partial,6,5.5,5.9,"bone marrow: 6 nTPM (vital, limit 2); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170627,GTSF1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.318348,0.299446,0.245039,0,2,partial,6,5.5,5.9,"bone marrow: 6 nTPM (vital, limit 2); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170627,GTSF1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.318348,0.299446,0.245039,0,2,partial,6,5.5,5.9,"bone marrow: 6 nTPM (vital, limit 2); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170627,GTSF1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.318348,0.27043,0.217828,0,2,partial,6,5.5,5.9,"bone marrow: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170627,GTSF1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.9189% (minimum 99%, Missing); basal ganglia: 98.3871% (minimum 99%, Missing); choroid plexus: 79.5652% (minimum 99%, Missing); colon: 87.1429% (minimum 97%, Missing); duodenum: 93.8462% (minimum 99%, Missing); hippocampal formation: 98.3871% (minimum 99%, Missing); hypothalamus: 97.8610% (minimum 99%, Missing); kidney: 88.4058% (minimum 95%, Enhanced); midbrain: 98.9189% (minimum 99%, Missing); pituitary gland: 98.3871% (minimum 99%, Missing); rectum: 83.5616% (minimum 97%, Missing); retina: 98.3871% (minimum 99%, Missing); small intestine: 91.9598% (minimum 99%, Missing)",0.0445652,-0.134384,-0.194348,0,9,partial,4.7,3.6,0.1,"choroid plexus: 4.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),84,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170703,TTLL6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344565,0.135616,0.0456522,0,9,partial,4.7,3.6,0.1,"choroid plexus: 4.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),84,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170703,TTLL6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344565,0.135616,0.0456522,0,9,partial,4.7,3.6,0.1,"choroid plexus: 4.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),84,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170703,TTLL6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344565,0.135616,0.0456522,0,9,partial,4.7,3.6,0.1,"choroid plexus: 4.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),84,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170703,TTLL6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344565,0.135616,0.0456522,0,9,partial,4.7,3.6,0.1,"choroid plexus: 4.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); kidney: 2.4 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),84,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170703,TTLL6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.2119% (minimum 90%, Approved); adrenal gland: 73.5714% (minimum 99%, Missing); amygdala: 85.8333% (minimum 99%, Missing); basal ganglia: 84.4262% (minimum 99%, Missing); bone marrow: 71.5278% (minimum 99%, Missing); cerebellum: 76.2963% (minimum 99%, Missing); cerebral cortex: 76.2963% (minimum 99%, Missing); choroid plexus: 71.5278% (minimum 99%, Missing); colon: 60.5882% (minimum 97%, Missing); duodenum: 70.0680% (minimum 99%, Missing); esophagus: 66.0256% (minimum 97%, Missing); heart muscle: 74.6377% (minimum 99%, Missing); hippocampal formation: 85.8333% (minimum 99%, Missing); hypothalamus: 86.5546% (minimum 99%, Missing); kidney: 69.5946% (minimum 99%, Missing); liver: 65.6051% (minimum 99%, Missing); lung: 65.1899% (minimum 99%, Missing); lymph node: 44.9782% (minimum 97%, Missing); midbrain: 85.8333% (minimum 99%, Missing); pancreas: 66.4516% (minimum 99%, Missing); parathyroid gland: 74.1007% (minimum 97%, Missing); pituitary gland: 76.8657% (minimum 99%, Missing); rectum: 59.8837% (minimum 97%, Missing); retina: 58.8571% (minimum 99%, Missing); salivary gland: 72.5352% (minimum 97%, Missing); skeletal muscle: 55.6757% (minimum 99%, Missing); skin: 55.6757% (minimum 95%, Missing); small intestine: 70.5479% (minimum 99%, Missing); smooth muscle: 63.1902% (minimum 99%, Missing); spinal cord: 82.4000% (minimum 99%, Missing); spleen: 65.6051% (minimum 95%, Missing); stomach: 70.0680% (minimum 97%, Missing); thymus: 45.1754% (minimum 95%, Missing); thyroid gland: 60.9467% (minimum 95%, Missing); tongue: 69.5946% (minimum 97%, Missing); urinary bladder: 69.1275% (minimum 97%, Missing)",-0.498246,-0.520218,-0.433243,0,1,partial,8.2,12.6,12.5,"lymph node: 12.6 nTPM (protected, limit 2); thymus: 12.5 nTPM (manageable, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); thyroid gland: 6.6 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170734,POLH,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.5714% (minimum 75%, Missing); bone marrow: 71.5278% (minimum 75%, Missing); choroid plexus: 71.5278% (minimum 75%, Missing); colon: 60.5882% (minimum 70%, Missing); duodenum: 70.0680% (minimum 75%, Missing); esophagus: 66.0256% (minimum 70%, Missing); heart muscle: 74.6377% (minimum 75%, Missing); kidney: 69.5946% (minimum 75%, Missing); liver: 65.6051% (minimum 75%, Missing); lung: 65.1899% (minimum 75%, Missing); lymph node: 44.9782% (minimum 70%, Missing); pancreas: 66.4516% (minimum 75%, Missing); rectum: 59.8837% (minimum 70%, Missing); retina: 58.8571% (minimum 75%, Missing); skeletal muscle: 55.6757% (minimum 75%, Missing); skin: 55.6757% (minimum 65%, Missing); small intestine: 70.5479% (minimum 75%, Missing); smooth muscle: 63.1902% (minimum 75%, Missing); thymus: 45.1754% (minimum 65%, Missing); thyroid gland: 60.9467% (minimum 65%, Missing); tongue: 69.5946% (minimum 70%, Missing); urinary bladder: 69.1275% (minimum 70%, Missing)",-0.198246,-0.250218,-0.193243,0,1,partial,8.2,12.6,12.5,"lymph node: 12.6 nTPM (protected, limit 2); thymus: 12.5 nTPM (manageable, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); thyroid gland: 6.6 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170734,POLH,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.5714% (minimum 75%, Missing); bone marrow: 71.5278% (minimum 75%, Missing); choroid plexus: 71.5278% (minimum 75%, Missing); colon: 60.5882% (minimum 70%, Missing); duodenum: 70.0680% (minimum 75%, Missing); esophagus: 66.0256% (minimum 70%, Missing); heart muscle: 74.6377% (minimum 75%, Missing); kidney: 69.5946% (minimum 75%, Missing); liver: 65.6051% (minimum 75%, Missing); lung: 65.1899% (minimum 75%, Missing); lymph node: 44.9782% (minimum 70%, Missing); pancreas: 66.4516% (minimum 75%, Missing); rectum: 59.8837% (minimum 70%, Missing); retina: 58.8571% (minimum 75%, Missing); skeletal muscle: 55.6757% (minimum 75%, Missing); skin: 55.6757% (minimum 65%, Missing); small intestine: 70.5479% (minimum 75%, Missing); smooth muscle: 63.1902% (minimum 75%, Missing); thymus: 45.1754% (minimum 65%, Missing); thyroid gland: 60.9467% (minimum 65%, Missing); tongue: 69.5946% (minimum 70%, Missing); urinary bladder: 69.1275% (minimum 70%, Missing)",-0.198246,-0.250218,-0.193243,0,1,partial,8.2,12.6,12.5,"lymph node: 12.6 nTPM (protected, limit 3); thymus: 12.5 nTPM (manageable, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); thyroid gland: 6.6 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.2 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170734,POLH,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.5714% (minimum 75%, Missing); bone marrow: 71.5278% (minimum 75%, Missing); choroid plexus: 71.5278% (minimum 75%, Missing); colon: 60.5882% (minimum 70%, Missing); duodenum: 70.0680% (minimum 75%, Missing); esophagus: 66.0256% (minimum 70%, Missing); heart muscle: 74.6377% (minimum 75%, Missing); kidney: 69.5946% (minimum 75%, Missing); liver: 65.6051% (minimum 75%, Missing); lung: 65.1899% (minimum 75%, Missing); lymph node: 44.9782% (minimum 70%, Missing); pancreas: 66.4516% (minimum 75%, Missing); rectum: 59.8837% (minimum 70%, Missing); retina: 58.8571% (minimum 75%, Missing); skeletal muscle: 55.6757% (minimum 75%, Missing); skin: 55.6757% (minimum 65%, Missing); small intestine: 70.5479% (minimum 75%, Missing); smooth muscle: 63.1902% (minimum 75%, Missing); thymus: 45.1754% (minimum 65%, Missing); thyroid gland: 60.9467% (minimum 65%, Missing); tongue: 69.5946% (minimum 70%, Missing); urinary bladder: 69.1275% (minimum 70%, Missing)",-0.198246,-0.250218,-0.193243,0,1,partial,8.2,12.6,12.5,"lymph node: 12.6 nTPM (protected, limit 3); thymus: 12.5 nTPM (manageable, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); thyroid gland: 6.6 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.2 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170734,POLH,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.5714% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 71.5278% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 71.5278% (minimum 75%, Baseline (adaptation disabled)); colon: 60.5882% (minimum 70%, Baseline (adaptation disabled)); duodenum: 70.0680% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.0256% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 74.6377% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.5946% (minimum 75%, Baseline (adaptation disabled)); liver: 65.6051% (minimum 75%, Baseline (adaptation disabled)); lung: 65.1899% (minimum 75%, Baseline (adaptation disabled)); lymph node: 44.9782% (minimum 70%, Baseline (adaptation disabled)); pancreas: 66.4516% (minimum 75%, Baseline (adaptation disabled)); rectum: 59.8837% (minimum 70%, Baseline (adaptation disabled)); retina: 58.8571% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 55.6757% (minimum 75%, Baseline (adaptation disabled)); skin: 55.6757% (minimum 65%, Baseline (adaptation disabled)); small intestine: 70.5479% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.1902% (minimum 75%, Baseline (adaptation disabled)); thymus: 45.1754% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 60.9467% (minimum 65%, Baseline (adaptation disabled)); tongue: 69.5946% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 69.1275% (minimum 70%, Baseline (adaptation disabled))",-0.198246,-0.250218,-0.193243,0,1,partial,8.2,12.6,12.5,"lymph node: 12.6 nTPM (protected, limit 3); thymus: 12.5 nTPM (manageable, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); thyroid gland: 6.6 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.2 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170734,POLH,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.00714286,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170748,RBMXL2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.247143,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170748,RBMXL2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.247143,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170748,RBMXL2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.247143,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170748,RBMXL2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.247143,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170748,RBMXL2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170777,TPD52L3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170777,TPD52L3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170777,TPD52L3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170777,TPD52L3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170777,TPD52L3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170782,OR10A4,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170782,OR10A4,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170782,OR10A4,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170782,OR10A4,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170782,OR10A4,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.7952% (minimum 99%, Missing)",0.0491877,0.03,-0.00204819,0,80,unavailable,1.5,0,0.1,"choroid plexus: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170788,DYDC1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349188,0.3,0.237952,0,80,unavailable,1.5,0,0.1,"choroid plexus: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170788,DYDC1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349188,0.3,0.237952,0,80,unavailable,1.5,0,0.1,"choroid plexus: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170788,DYDC1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349188,0.3,0.237952,0,80,unavailable,1.5,0,0.1,"choroid plexus: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170788,DYDC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349188,0.3,0.237952,0,80,unavailable,1.5,0,0.1,"choroid plexus: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170788,DYDC1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 90.0000% (minimum 99%, Missing)",0.0142857,0.03,-0.09,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170820,FSHR,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.314286,0.3,0.15,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170820,FSHR,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.314286,0.3,0.15,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170820,FSHR,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.314286,0.3,0.15,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170820,FSHR,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.314286,0.3,0.15,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170820,FSHR,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.00165992,0,2,partial,1.4,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170848,PSG6,admission_only,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.247921,0,2,partial,1.4,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170848,PSG6,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.247921,0,2,partial,1.4,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170848,PSG6,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.247921,0,2,partial,1.4,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170848,PSG6,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347921,0.3,0.22166,0,2,partial,1.4,0,0.1,"bone marrow: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170848,PSG6,current_fixed,True,False,False,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.2784% (minimum 95%, Missing); adrenal gland: 49.5690% (minimum 99%, Missing); amygdala: 63.1868% (minimum 99%, Missing); basal ganglia: 68.4524% (minimum 99%, Missing); bone marrow: 73.7179% (minimum 99%, Missing); cerebellum: 44.7471% (minimum 99%, Missing); cerebral cortex: 59.7920% (minimum 99%, Missing); choroid plexus: 76.8374% (minimum 99%, Missing); colon: 76.3274% (minimum 97%, Missing); duodenum: 84.5588% (minimum 99%, Missing); esophagus: 44.1176% (minimum 97%, Missing); heart muscle: 67.6471% (minimum 98%, Approved); hippocampal formation: 63.3028% (minimum 99%, Missing); hypothalamus: 63.6531% (minimum 99%, Missing); kidney: 59.6886% (minimum 99%, Missing); liver: 32.7947% (minimum 99%, Missing); lung: 68.4524% (minimum 98%, Approved); lymph node: 68.8623% (minimum 97%, Missing); midbrain: 62.8415% (minimum 99%, Missing); pancreas: 55.5556% (minimum 99%, Missing); parathyroid gland: 90.5512% (minimum 97%, Missing); pituitary gland: 76.3274% (minimum 99%, Missing); rectum: 79.6767% (minimum 97%, Missing); retina: 70.2648% (minimum 99%, Missing); salivary gland: 71.8750% (minimum 97%, Missing); skeletal muscle: 52.5114% (minimum 99%, Missing); skin: 53.6547% (minimum 95%, Missing); small intestine: 81.7536% (minimum 99%, Missing); smooth muscle: 78.7671% (minimum 98%, Approved); spinal cord: 52.1936% (minimum 99%, Missing); spleen: 50.6608% (minimum 95%, Missing); stomach: 74.6753% (minimum 97%, Missing); thymus: 65.8397% (minimum 95%, Missing); thyroid gland: 85.3960% (minimum 95%, Missing); tongue: 59.2784% (minimum 97%, Missing); urinary bladder: 69.6970% (minimum 97%, Missing)",-0.443392,-0.528824,-0.662053,0,2,partial,70.7,43.7,33.6,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 2); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spleen: 33.6 nTPM (manageable, limit 5); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); pancreas: 27.6 nTPM (vital, limit 1); adipose tissue: 23.7 nTPM (manageable, limit 5); tongue: 23.7 nTPM (protected, limit 2); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); thymus: 17.9 nTPM (manageable, limit 5); heart muscle: 16.5 nTPM (vital, limit 2); lung: 15.9 nTPM (vital, limit 2); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 2); urinary bladder: 15 nTPM (protected, limit 2); retina: 14.6 nTPM (vital, limit 1); salivary gland: 13.5 nTPM (protected, limit 2); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 2); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 2); rectum: 8.8 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170873,MTSS1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.2784% (minimum 65%, Missing); adrenal gland: 49.5690% (minimum 75%, Missing); amygdala: 63.1868% (minimum 75%, Missing); basal ganglia: 68.4524% (minimum 75%, Missing); bone marrow: 73.7179% (minimum 75%, Missing); cerebellum: 44.7471% (minimum 75%, Missing); cerebral cortex: 59.7920% (minimum 75%, Missing); esophagus: 44.1176% (minimum 70%, Missing); heart muscle: 67.6471% (minimum 70%, Approved); hippocampal formation: 63.3028% (minimum 75%, Missing); hypothalamus: 63.6531% (minimum 75%, Missing); kidney: 59.6886% (minimum 75%, Missing); liver: 32.7947% (minimum 75%, Missing); lung: 68.4524% (minimum 70%, Approved); lymph node: 68.8623% (minimum 70%, Missing); midbrain: 62.8415% (minimum 75%, Missing); pancreas: 55.5556% (minimum 75%, Missing); retina: 70.2648% (minimum 75%, Missing); skeletal muscle: 52.5114% (minimum 75%, Missing); skin: 53.6547% (minimum 65%, Missing); spinal cord: 52.1936% (minimum 75%, Missing); spleen: 50.6608% (minimum 65%, Missing); tongue: 59.2784% (minimum 70%, Missing); urinary bladder: 69.6970% (minimum 70%, Missing)",-0.143392,-0.258824,-0.422053,0,2,partial,70.7,43.7,33.6,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 2); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spleen: 33.6 nTPM (manageable, limit 5); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); pancreas: 27.6 nTPM (vital, limit 1); adipose tissue: 23.7 nTPM (manageable, limit 5); tongue: 23.7 nTPM (protected, limit 2); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); thymus: 17.9 nTPM (manageable, limit 5); heart muscle: 16.5 nTPM (vital, limit 2); lung: 15.9 nTPM (vital, limit 2); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 2); urinary bladder: 15 nTPM (protected, limit 2); retina: 14.6 nTPM (vital, limit 1); salivary gland: 13.5 nTPM (protected, limit 2); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 2); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 2); rectum: 8.8 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170873,MTSS1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.2784% (minimum 65%, Missing); adrenal gland: 49.5690% (minimum 75%, Missing); amygdala: 63.1868% (minimum 75%, Missing); basal ganglia: 68.4524% (minimum 75%, Missing); bone marrow: 73.7179% (minimum 75%, Missing); cerebellum: 44.7471% (minimum 75%, Missing); cerebral cortex: 59.7920% (minimum 75%, Missing); esophagus: 44.1176% (minimum 70%, Missing); heart muscle: 67.6471% (minimum 70%, Approved); hippocampal formation: 63.3028% (minimum 75%, Missing); hypothalamus: 63.6531% (minimum 75%, Missing); kidney: 59.6886% (minimum 75%, Missing); liver: 32.7947% (minimum 75%, Missing); lung: 68.4524% (minimum 70%, Approved); lymph node: 68.8623% (minimum 70%, Missing); midbrain: 62.8415% (minimum 75%, Missing); pancreas: 55.5556% (minimum 75%, Missing); retina: 70.2648% (minimum 75%, Missing); skeletal muscle: 52.5114% (minimum 75%, Missing); skin: 53.6547% (minimum 65%, Missing); spinal cord: 52.1936% (minimum 75%, Missing); spleen: 50.6608% (minimum 65%, Missing); tongue: 59.2784% (minimum 70%, Missing); urinary bladder: 69.6970% (minimum 70%, Missing)",-0.143392,-0.258824,-0.422053,0,2,partial,70.7,43.7,33.6,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 3); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spleen: 33.6 nTPM (manageable, limit 5); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); pancreas: 27.6 nTPM (vital, limit 1); adipose tissue: 23.7 nTPM (manageable, limit 5); tongue: 23.7 nTPM (protected, limit 3); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); thymus: 17.9 nTPM (manageable, limit 5); heart muscle: 16.5 nTPM (vital, limit 2); lung: 15.9 nTPM (vital, limit 2); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 3); urinary bladder: 15 nTPM (protected, limit 3); retina: 14.6 nTPM (vital, limit 1); salivary gland: 13.5 nTPM (protected, limit 3); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 3); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 2); rectum: 8.8 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170873,MTSS1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.2784% (minimum 65%, Missing); adrenal gland: 49.5690% (minimum 75%, Missing); amygdala: 63.1868% (minimum 75%, Missing); basal ganglia: 68.4524% (minimum 75%, Missing); bone marrow: 73.7179% (minimum 75%, Missing); cerebellum: 44.7471% (minimum 75%, Missing); cerebral cortex: 59.7920% (minimum 75%, Missing); esophagus: 44.1176% (minimum 70%, Missing); heart muscle: 67.6471% (minimum 70%, Approved); hippocampal formation: 63.3028% (minimum 75%, Missing); hypothalamus: 63.6531% (minimum 75%, Missing); kidney: 59.6886% (minimum 75%, Missing); liver: 32.7947% (minimum 75%, Missing); lung: 68.4524% (minimum 70%, Approved); lymph node: 68.8623% (minimum 70%, Missing); midbrain: 62.8415% (minimum 75%, Missing); pancreas: 55.5556% (minimum 75%, Missing); retina: 70.2648% (minimum 75%, Missing); skeletal muscle: 52.5114% (minimum 75%, Missing); skin: 53.6547% (minimum 65%, Missing); spinal cord: 52.1936% (minimum 75%, Missing); spleen: 50.6608% (minimum 65%, Missing); tongue: 59.2784% (minimum 70%, Missing); urinary bladder: 69.6970% (minimum 70%, Missing)",-0.143392,-0.258824,-0.422053,0,2,partial,70.7,43.7,33.6,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 3); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spleen: 33.6 nTPM (manageable, limit 5); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); pancreas: 27.6 nTPM (vital, limit 1); adipose tissue: 23.7 nTPM (manageable, limit 5); tongue: 23.7 nTPM (protected, limit 3); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); thymus: 17.9 nTPM (manageable, limit 5); heart muscle: 16.5 nTPM (vital, limit 2); lung: 15.9 nTPM (vital, limit 2); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 3); urinary bladder: 15 nTPM (protected, limit 3); retina: 14.6 nTPM (vital, limit 1); salivary gland: 13.5 nTPM (protected, limit 3); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 3); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 2); rectum: 8.8 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170873,MTSS1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.2784% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 49.5690% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.1868% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 68.4524% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 73.7179% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 44.7471% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 59.7920% (minimum 75%, Baseline (adaptation disabled)); esophagus: 44.1176% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 67.6471% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.3028% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.6531% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.6886% (minimum 75%, Baseline (adaptation disabled)); liver: 32.7947% (minimum 75%, Baseline (adaptation disabled)); lung: 68.4524% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.8623% (minimum 70%, Baseline (adaptation disabled)); midbrain: 62.8415% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.5556% (minimum 75%, Baseline (adaptation disabled)); retina: 70.2648% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 52.5114% (minimum 75%, Baseline (adaptation disabled)); skin: 53.6547% (minimum 65%, Baseline (adaptation disabled)); spinal cord: 52.1936% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.6608% (minimum 65%, Baseline (adaptation disabled)); tongue: 59.2784% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 69.6970% (minimum 70%, Baseline (adaptation disabled))",-0.143392,-0.258824,-0.422053,0,2,partial,70.7,43.7,33.6,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 3); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spleen: 33.6 nTPM (manageable, limit 5); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); pancreas: 27.6 nTPM (vital, limit 1); adipose tissue: 23.7 nTPM (manageable, limit 5); tongue: 23.7 nTPM (protected, limit 3); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); thymus: 17.9 nTPM (manageable, limit 5); heart muscle: 16.5 nTPM (vital, limit 1); lung: 15.9 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 3); urinary bladder: 15 nTPM (protected, limit 3); retina: 14.6 nTPM (vital, limit 1); salivary gland: 13.5 nTPM (protected, limit 3); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 3); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170873,MTSS1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.1837% (minimum 90%, Approved); adrenal gland: 54.2056% (minimum 99%, Missing); amygdala: 52.2523% (minimum 99%, Missing); basal ganglia: 54.7170% (minimum 99%, Missing); bone marrow: 78.9116% (minimum 98%, Approved); cerebellum: 52.2523% (minimum 99%, Missing); cerebral cortex: 42.3358% (minimum 99%, Missing); choroid plexus: 61.0526% (minimum 99%, Missing); colon: 62.7027% (minimum 97%, Missing); duodenum: 69.4611% (minimum 99%, Missing); esophagus: 60.1036% (minimum 95%, Approved); heart muscle: 43.4457% (minimum 99%, Missing); hippocampal formation: 53.7037% (minimum 99%, Missing); hypothalamus: 54.2056% (minimum 99%, Missing); kidney: 55.7692% (minimum 99%, Missing); liver: 63.0435% (minimum 98%, Approved); lung: 58.5859% (minimum 99%, Missing); lymph node: 54.9763% (minimum 95%, Approved); midbrain: 52.7273% (minimum 99%, Missing); pancreas: 56.0386% (minimum 98%, Approved); parathyroid gland: 59.4872% (minimum 95%, Approved); pituitary gland: 55.2381% (minimum 99%, Missing); rectum: 65.5367% (minimum 97%, Missing); retina: 26.5446% (minimum 99%, Missing); salivary gland: 62.3656% (minimum 97%, Missing); skeletal muscle: 50.4348% (minimum 99%, Missing); skin: 72.9560% (minimum 95%, Missing); small intestine: 67.4419% (minimum 99%, Missing); smooth muscle: 53.4562% (minimum 98%, Approved); spinal cord: 55.5024% (minimum 99%, Missing); spleen: 58.5859% (minimum 90%, Approved); stomach: 62.3656% (minimum 97%, Missing); thymus: 58.8832% (minimum 95%, Missing); thyroid gland: 47.5410% (minimum 95%, Missing); tongue: 41.8773% (minimum 97%, Missing); urinary bladder: 57.7114% (minimum 95%, Approved)",-0.47459,-0.551227,-0.724554,0,7,partial,32.1,16.1,12.8,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (manageable, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 2); hippocampal formation: 10 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 4); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 2); urinary bladder: 8.5 nTPM (protected, limit 4); lung: 8.2 nTPM (vital, limit 1); thymus: 8.1 nTPM (manageable, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 4); esophagus: 7.7 nTPM (protected, limit 4); choroid plexus: 7.4 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); colon: 6.9 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 2); rectum: 6.1 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170903,MSANTD4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.1837% (minimum 60%, Approved); adrenal gland: 54.2056% (minimum 75%, Missing); amygdala: 52.2523% (minimum 75%, Missing); basal ganglia: 54.7170% (minimum 75%, Missing); cerebellum: 52.2523% (minimum 75%, Missing); cerebral cortex: 42.3358% (minimum 75%, Missing); choroid plexus: 61.0526% (minimum 75%, Missing); colon: 62.7027% (minimum 70%, Missing); duodenum: 69.4611% (minimum 75%, Missing); esophagus: 60.1036% (minimum 65%, Approved); heart muscle: 43.4457% (minimum 75%, Missing); hippocampal formation: 53.7037% (minimum 75%, Missing); hypothalamus: 54.2056% (minimum 75%, Missing); kidney: 55.7692% (minimum 75%, Missing); liver: 63.0435% (minimum 70%, Approved); lung: 58.5859% (minimum 75%, Missing); lymph node: 54.9763% (minimum 65%, Approved); midbrain: 52.7273% (minimum 75%, Missing); pancreas: 56.0386% (minimum 70%, Approved); parathyroid gland: 59.4872% (minimum 65%, Approved); pituitary gland: 55.2381% (minimum 75%, Missing); rectum: 65.5367% (minimum 70%, Missing); retina: 26.5446% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); skeletal muscle: 50.4348% (minimum 75%, Missing); small intestine: 67.4419% (minimum 75%, Missing); smooth muscle: 53.4562% (minimum 70%, Approved); spinal cord: 55.5024% (minimum 75%, Missing); spleen: 58.5859% (minimum 60%, Approved); stomach: 62.3656% (minimum 70%, Missing); thymus: 58.8832% (minimum 65%, Missing); thyroid gland: 47.5410% (minimum 65%, Missing); tongue: 41.8773% (minimum 70%, Missing); urinary bladder: 57.7114% (minimum 65%, Approved)",-0.17459,-0.281227,-0.484554,0,7,partial,32.1,16.1,12.8,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (manageable, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 2); hippocampal formation: 10 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 4); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 2); urinary bladder: 8.5 nTPM (protected, limit 4); lung: 8.2 nTPM (vital, limit 1); thymus: 8.1 nTPM (manageable, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 4); esophagus: 7.7 nTPM (protected, limit 4); choroid plexus: 7.4 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); colon: 6.9 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 2); rectum: 6.1 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170903,MSANTD4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.1837% (minimum 60%, Approved); adrenal gland: 54.2056% (minimum 75%, Missing); amygdala: 52.2523% (minimum 75%, Missing); basal ganglia: 54.7170% (minimum 75%, Missing); cerebellum: 52.2523% (minimum 75%, Missing); cerebral cortex: 42.3358% (minimum 75%, Missing); choroid plexus: 61.0526% (minimum 75%, Missing); colon: 62.7027% (minimum 70%, Missing); duodenum: 69.4611% (minimum 75%, Missing); esophagus: 60.1036% (minimum 65%, Approved); heart muscle: 43.4457% (minimum 75%, Missing); hippocampal formation: 53.7037% (minimum 75%, Missing); hypothalamus: 54.2056% (minimum 75%, Missing); kidney: 55.7692% (minimum 75%, Missing); liver: 63.0435% (minimum 70%, Approved); lung: 58.5859% (minimum 75%, Missing); lymph node: 54.9763% (minimum 65%, Approved); midbrain: 52.7273% (minimum 75%, Missing); pancreas: 56.0386% (minimum 70%, Approved); parathyroid gland: 59.4872% (minimum 65%, Approved); pituitary gland: 55.2381% (minimum 75%, Missing); rectum: 65.5367% (minimum 70%, Missing); retina: 26.5446% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); skeletal muscle: 50.4348% (minimum 75%, Missing); small intestine: 67.4419% (minimum 75%, Missing); smooth muscle: 53.4562% (minimum 70%, Approved); spinal cord: 55.5024% (minimum 75%, Missing); spleen: 58.5859% (minimum 60%, Approved); stomach: 62.3656% (minimum 70%, Missing); thymus: 58.8832% (minimum 65%, Missing); thyroid gland: 47.5410% (minimum 65%, Missing); tongue: 41.8773% (minimum 70%, Missing); urinary bladder: 57.7114% (minimum 65%, Approved)",-0.17459,-0.281227,-0.484554,0,7,partial,32.1,16.1,12.8,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (manageable, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 2); hippocampal formation: 10 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 4); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 2); urinary bladder: 8.5 nTPM (protected, limit 4); lung: 8.2 nTPM (vital, limit 1); thymus: 8.1 nTPM (manageable, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 4); esophagus: 7.7 nTPM (protected, limit 4); choroid plexus: 7.4 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); colon: 6.9 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 2); rectum: 6.1 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170903,MSANTD4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.1837% (minimum 60%, Approved); adrenal gland: 54.2056% (minimum 75%, Missing); amygdala: 52.2523% (minimum 75%, Missing); basal ganglia: 54.7170% (minimum 75%, Missing); cerebellum: 52.2523% (minimum 75%, Missing); cerebral cortex: 42.3358% (minimum 75%, Missing); choroid plexus: 61.0526% (minimum 75%, Missing); colon: 62.7027% (minimum 70%, Missing); duodenum: 69.4611% (minimum 75%, Missing); esophagus: 60.1036% (minimum 65%, Approved); heart muscle: 43.4457% (minimum 75%, Missing); hippocampal formation: 53.7037% (minimum 75%, Missing); hypothalamus: 54.2056% (minimum 75%, Missing); kidney: 55.7692% (minimum 75%, Missing); liver: 63.0435% (minimum 70%, Approved); lung: 58.5859% (minimum 75%, Missing); lymph node: 54.9763% (minimum 65%, Approved); midbrain: 52.7273% (minimum 75%, Missing); pancreas: 56.0386% (minimum 70%, Approved); parathyroid gland: 59.4872% (minimum 65%, Approved); pituitary gland: 55.2381% (minimum 75%, Missing); rectum: 65.5367% (minimum 70%, Missing); retina: 26.5446% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); skeletal muscle: 50.4348% (minimum 75%, Missing); small intestine: 67.4419% (minimum 75%, Missing); smooth muscle: 53.4562% (minimum 70%, Approved); spinal cord: 55.5024% (minimum 75%, Missing); spleen: 58.5859% (minimum 60%, Approved); stomach: 62.3656% (minimum 70%, Missing); thymus: 58.8832% (minimum 65%, Missing); thyroid gland: 47.5410% (minimum 65%, Missing); tongue: 41.8773% (minimum 70%, Missing); urinary bladder: 57.7114% (minimum 65%, Approved)",-0.17459,-0.281227,-0.484554,0,7,partial,32.1,16.1,12.8,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (manageable, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 2); hippocampal formation: 10 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 4); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 2); urinary bladder: 8.5 nTPM (protected, limit 4); lung: 8.2 nTPM (vital, limit 1); thymus: 8.1 nTPM (manageable, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 4); esophagus: 7.7 nTPM (protected, limit 4); choroid plexus: 7.4 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); colon: 6.9 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 2); rectum: 6.1 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170903,MSANTD4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.1837% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 54.2056% (minimum 75%, Baseline (adaptation disabled)); amygdala: 52.2523% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.7170% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 52.2523% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 42.3358% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 61.0526% (minimum 75%, Baseline (adaptation disabled)); colon: 62.7027% (minimum 70%, Baseline (adaptation disabled)); duodenum: 69.4611% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.1036% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 43.4457% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 53.7037% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 54.2056% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.7692% (minimum 75%, Baseline (adaptation disabled)); liver: 63.0435% (minimum 75%, Baseline (adaptation disabled)); lung: 58.5859% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.9763% (minimum 70%, Baseline (adaptation disabled)); midbrain: 52.7273% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.0386% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.4872% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.2381% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.5367% (minimum 70%, Baseline (adaptation disabled)); retina: 26.5446% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.3656% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 50.4348% (minimum 75%, Baseline (adaptation disabled)); small intestine: 67.4419% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.4562% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 55.5024% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.5859% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.3656% (minimum 70%, Baseline (adaptation disabled)); thymus: 58.8832% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 47.5410% (minimum 65%, Baseline (adaptation disabled)); tongue: 41.8773% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.7114% (minimum 70%, Baseline (adaptation disabled))",-0.17459,-0.281227,-0.484554,0,7,partial,32.1,16.1,12.8,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (manageable, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 3); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 3); lung: 8.2 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); thymus: 8.1 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 3); esophagus: 7.7 nTPM (protected, limit 3); choroid plexus: 7.4 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); colon: 6.9 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170903,MSANTD4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170925,TEX13B,admission_only,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170925,TEX13B,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170925,TEX13B,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170925,TEX13B,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170925,TEX13B,current_fixed,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.1481% (minimum 90%, Approved); adrenal gland: 51.5873% (minimum 99%, Missing); amygdala: 54.1667% (minimum 99%, Missing); basal ganglia: 54.1667% (minimum 99%, Missing); bone marrow: 78.3133% (minimum 98%, Approved); cerebellum: 47.4453% (minimum 98%, Approved); cerebral cortex: 50.3876% (minimum 99%, Missing); choroid plexus: 71.4286% (minimum 99%, Missing); colon: 58.5586% (minimum 97%, Missing); duodenum: 60.1852% (minimum 98%, Approved); esophagus: 56.0345% (minimum 97%, Missing); heart muscle: 36.5169% (minimum 99%, Missing); hippocampal formation: 53.7190% (minimum 99%, Missing); hypothalamus: 52.4194% (minimum 99%, Missing); kidney: 51.5873% (minimum 99%, Missing); liver: 52.8455% (minimum 98%, Approved); lung: 60.7477% (minimum 99%, Missing); lymph node: 49.6183% (minimum 95%, Approved); midbrain: 53.2787% (minimum 99%, Missing); pancreas: 47.7941% (minimum 99%, Missing); parathyroid gland: 58.5586% (minimum 97%, Missing); pituitary gland: 59.0909% (minimum 99%, Missing); rectum: 60.7477% (minimum 95%, Approved); retina: 45.4545% (minimum 99%, Missing); salivary gland: 53.7190% (minimum 97%, Missing); skeletal muscle: 28.3843% (minimum 98%, Approved); skin: 43.3333% (minimum 95%, Missing); small intestine: 60.1852% (minimum 98%, Approved); smooth muscle: 51.5873% (minimum 98%, Approved); spinal cord: 52.4194% (minimum 99%, Missing); spleen: 53.2787% (minimum 90%, Approved); stomach: 57.0175% (minimum 97%, Missing); thymus: 56.5217% (minimum 95%, Missing); thyroid gland: 50.7812% (minimum 95%, Missing); tongue: 37.3563% (minimum 97%, Missing); urinary bladder: 54.6218% (minimum 95%, Approved)",-0.516667,-0.596437,-0.696157,0,7,partial,16.4,10.9,8.5,"skeletal muscle: 16.4 nTPM (vital, limit 2); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 2); pancreas: 7.1 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 4); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 2); kidney: 6.1 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 2); midbrain: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); hippocampal formation: 5.6 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 4); esophagus: 5.1 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 2); duodenum: 4.3 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 4); lung: 4.2 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170946,DNAJC24,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.1481% (minimum 60%, Approved); adrenal gland: 51.5873% (minimum 75%, Missing); amygdala: 54.1667% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebellum: 47.4453% (minimum 70%, Approved); cerebral cortex: 50.3876% (minimum 75%, Missing); choroid plexus: 71.4286% (minimum 75%, Missing); colon: 58.5586% (minimum 70%, Missing); duodenum: 60.1852% (minimum 70%, Approved); esophagus: 56.0345% (minimum 70%, Missing); heart muscle: 36.5169% (minimum 75%, Missing); hippocampal formation: 53.7190% (minimum 75%, Missing); hypothalamus: 52.4194% (minimum 75%, Missing); kidney: 51.5873% (minimum 75%, Missing); liver: 52.8455% (minimum 70%, Approved); lung: 60.7477% (minimum 75%, Missing); lymph node: 49.6183% (minimum 65%, Approved); midbrain: 53.2787% (minimum 75%, Missing); pancreas: 47.7941% (minimum 75%, Missing); parathyroid gland: 58.5586% (minimum 70%, Missing); pituitary gland: 59.0909% (minimum 75%, Missing); rectum: 60.7477% (minimum 65%, Approved); retina: 45.4545% (minimum 75%, Missing); salivary gland: 53.7190% (minimum 70%, Missing); skeletal muscle: 28.3843% (minimum 70%, Approved); skin: 43.3333% (minimum 65%, Missing); small intestine: 60.1852% (minimum 70%, Approved); smooth muscle: 51.5873% (minimum 70%, Approved); spinal cord: 52.4194% (minimum 75%, Missing); spleen: 53.2787% (minimum 60%, Approved); stomach: 57.0175% (minimum 70%, Missing); thymus: 56.5217% (minimum 65%, Missing); thyroid gland: 50.7812% (minimum 65%, Missing); tongue: 37.3563% (minimum 70%, Missing); urinary bladder: 54.6218% (minimum 65%, Approved)",-0.216667,-0.326437,-0.416157,0,7,partial,16.4,10.9,8.5,"skeletal muscle: 16.4 nTPM (vital, limit 2); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 2); pancreas: 7.1 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 4); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 2); kidney: 6.1 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 2); midbrain: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); hippocampal formation: 5.6 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 4); esophagus: 5.1 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 2); duodenum: 4.3 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 4); lung: 4.2 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170946,DNAJC24,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.1481% (minimum 60%, Approved); adrenal gland: 51.5873% (minimum 75%, Missing); amygdala: 54.1667% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebellum: 47.4453% (minimum 70%, Approved); cerebral cortex: 50.3876% (minimum 75%, Missing); choroid plexus: 71.4286% (minimum 75%, Missing); colon: 58.5586% (minimum 70%, Missing); duodenum: 60.1852% (minimum 70%, Approved); esophagus: 56.0345% (minimum 70%, Missing); heart muscle: 36.5169% (minimum 75%, Missing); hippocampal formation: 53.7190% (minimum 75%, Missing); hypothalamus: 52.4194% (minimum 75%, Missing); kidney: 51.5873% (minimum 75%, Missing); liver: 52.8455% (minimum 70%, Approved); lung: 60.7477% (minimum 75%, Missing); lymph node: 49.6183% (minimum 65%, Approved); midbrain: 53.2787% (minimum 75%, Missing); pancreas: 47.7941% (minimum 75%, Missing); parathyroid gland: 58.5586% (minimum 70%, Missing); pituitary gland: 59.0909% (minimum 75%, Missing); rectum: 60.7477% (minimum 65%, Approved); retina: 45.4545% (minimum 75%, Missing); salivary gland: 53.7190% (minimum 70%, Missing); skeletal muscle: 28.3843% (minimum 70%, Approved); skin: 43.3333% (minimum 65%, Missing); small intestine: 60.1852% (minimum 70%, Approved); smooth muscle: 51.5873% (minimum 70%, Approved); spinal cord: 52.4194% (minimum 75%, Missing); spleen: 53.2787% (minimum 60%, Approved); stomach: 57.0175% (minimum 70%, Missing); thymus: 56.5217% (minimum 65%, Missing); thyroid gland: 50.7812% (minimum 65%, Missing); tongue: 37.3563% (minimum 70%, Missing); urinary bladder: 54.6218% (minimum 65%, Approved)",-0.216667,-0.326437,-0.416157,0,7,partial,16.4,10.9,8.5,"skeletal muscle: 16.4 nTPM (vital, limit 2); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 2); pancreas: 7.1 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 4); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 2); kidney: 6.1 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 2); midbrain: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); hippocampal formation: 5.6 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 4); esophagus: 5.1 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); parathyroid gland: 4.6 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 2); duodenum: 4.3 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 4); lung: 4.2 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170946,DNAJC24,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.1481% (minimum 60%, Approved); adrenal gland: 51.5873% (minimum 75%, Missing); amygdala: 54.1667% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebellum: 47.4453% (minimum 70%, Approved); cerebral cortex: 50.3876% (minimum 75%, Missing); choroid plexus: 71.4286% (minimum 75%, Missing); colon: 58.5586% (minimum 70%, Missing); duodenum: 60.1852% (minimum 70%, Approved); esophagus: 56.0345% (minimum 70%, Missing); heart muscle: 36.5169% (minimum 75%, Missing); hippocampal formation: 53.7190% (minimum 75%, Missing); hypothalamus: 52.4194% (minimum 75%, Missing); kidney: 51.5873% (minimum 75%, Missing); liver: 52.8455% (minimum 70%, Approved); lung: 60.7477% (minimum 75%, Missing); lymph node: 49.6183% (minimum 65%, Approved); midbrain: 53.2787% (minimum 75%, Missing); pancreas: 47.7941% (minimum 75%, Missing); parathyroid gland: 58.5586% (minimum 70%, Missing); pituitary gland: 59.0909% (minimum 75%, Missing); rectum: 60.7477% (minimum 65%, Approved); retina: 45.4545% (minimum 75%, Missing); salivary gland: 53.7190% (minimum 70%, Missing); skeletal muscle: 28.3843% (minimum 70%, Approved); skin: 43.3333% (minimum 65%, Missing); small intestine: 60.1852% (minimum 70%, Approved); smooth muscle: 51.5873% (minimum 70%, Approved); spinal cord: 52.4194% (minimum 75%, Missing); spleen: 53.2787% (minimum 60%, Approved); stomach: 57.0175% (minimum 70%, Missing); thymus: 56.5217% (minimum 65%, Missing); thyroid gland: 50.7812% (minimum 65%, Missing); tongue: 37.3563% (minimum 70%, Missing); urinary bladder: 54.6218% (minimum 65%, Approved)",-0.216667,-0.326437,-0.416157,0,7,partial,16.4,10.9,8.5,"skeletal muscle: 16.4 nTPM (vital, limit 2); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 2); pancreas: 7.1 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 4); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 2); kidney: 6.1 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 2); midbrain: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); hippocampal formation: 5.6 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 4); esophagus: 5.1 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); parathyroid gland: 4.6 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 2); duodenum: 4.3 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 4); lung: 4.2 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170946,DNAJC24,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.1481% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 51.5873% (minimum 75%, Baseline (adaptation disabled)); amygdala: 54.1667% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.1667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 47.4453% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.3876% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 71.4286% (minimum 75%, Baseline (adaptation disabled)); colon: 58.5586% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.1852% (minimum 75%, Baseline (adaptation disabled)); esophagus: 56.0345% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 36.5169% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 53.7190% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 52.4194% (minimum 75%, Baseline (adaptation disabled)); kidney: 51.5873% (minimum 75%, Baseline (adaptation disabled)); liver: 52.8455% (minimum 75%, Baseline (adaptation disabled)); lung: 60.7477% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.6183% (minimum 70%, Baseline (adaptation disabled)); midbrain: 53.2787% (minimum 75%, Baseline (adaptation disabled)); pancreas: 47.7941% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.5586% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 59.0909% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.7477% (minimum 70%, Baseline (adaptation disabled)); retina: 45.4545% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.7190% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 28.3843% (minimum 75%, Baseline (adaptation disabled)); skin: 43.3333% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.1852% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 51.5873% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 52.4194% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.2787% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.0175% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.5217% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.7812% (minimum 65%, Baseline (adaptation disabled)); tongue: 37.3563% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 54.6218% (minimum 70%, Baseline (adaptation disabled))",-0.216667,-0.326437,-0.466157,0,7,partial,16.4,10.9,8.5,"skeletal muscle: 16.4 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); lymph node: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); kidney: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); hippocampal formation: 5.6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); amygdala: 5.5 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); esophagus: 5.1 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); parathyroid gland: 4.6 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); pituitary gland: 4.5 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 3); choroid plexus: 2.6 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170946,DNAJC24,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.00407407,0,7,partial,0.7,0,0,,kidney / proximal tubules (cell body): Medium (Supported),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170948,MBD3L1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,7,partial,0.7,0,0,,kidney / proximal tubules (cell body): Medium (Supported),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170948,MBD3L1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,7,partial,0.7,0,0,,kidney / proximal tubules (cell body): Medium (Supported),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170948,MBD3L1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,7,partial,0.7,0,0,,kidney / proximal tubules (cell body): Medium (Supported),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170948,MBD3L1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.224074,0,7,partial,0.7,0,0,,kidney / proximal tubules (cell body): Medium (Supported),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170948,MBD3L1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170950,PGK2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170950,PGK2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170950,PGK2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170950,PGK2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170950,PGK2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000170953,OR8B12,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000170953,OR8B12,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000170953,OR8B12,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000170953,OR8B12,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000170953,OR8B12,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0.1,0.1,0.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170965,PLAC1,admission_only,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.1,0.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170965,PLAC1,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.1,0.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170965,PLAC1,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.1,0.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170965,PLAC1,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
True,compatible,,True,True,True,,0.342647,0.29631,0.24631,0,2,partial,0.1,0.1,0.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170965,PLAC1,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170967,DDI1,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170967,DDI1,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170967,DDI1,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170967,DDI1,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000170967,DDI1,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171060,C8orf74,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171060,C8orf74,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171060,C8orf74,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171060,C8orf74,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171060,C8orf74,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 90%, Approved); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 70.5882% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 99%, Missing); cerebral cortex: 41.3793% (minimum 99%, Missing); choroid plexus: 92.3077% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 92.3077% (minimum 98%, Approved); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 60.0000% (minimum 99%, Missing); lung: 92.3077% (minimum 99%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pituitary gland: 50.0000% (minimum 99%, Missing); rectum: 85.7143% (minimum 97%, Missing); retina: 63.1579% (minimum 99%, Missing); salivary gland: 92.3077% (minimum 95%, Approved); skin: 92.3077% (minimum 95%, Missing); small intestine: 85.7143% (minimum 98%, Approved); smooth muscle: 92.3077% (minimum 98%, Approved); spinal cord: 80.0000% (minimum 99%, Missing); stomach: 92.3077% (minimum 95%, Approved); thyroid gland: 80.0000% (minimum 95%, Missing)",-0.15,-0.303333,-0.576207,0,1,partial,1.7,0.6,0.3,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171094,ALK,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 70.5882% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); cerebral cortex: 41.3793% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); hypothalamus: 60.0000% (minimum 75%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 63.1579% (minimum 75%, Missing)",0.15,-0.0333333,-0.336207,0,1,partial,1.7,0.6,0.3,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171094,ALK,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 70.5882% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); cerebral cortex: 41.3793% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); hypothalamus: 60.0000% (minimum 75%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 63.1579% (minimum 75%, Missing)",0.15,-0.0333333,-0.336207,0,1,partial,1.7,0.6,0.3,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171094,ALK,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 70.5882% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); cerebral cortex: 41.3793% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); hypothalamus: 60.0000% (minimum 75%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 63.1579% (minimum 75%, Missing)",0.15,-0.0333333,-0.336207,0,1,partial,1.7,0.6,0.3,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171094,ALK,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); amygdala: 70.5882% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 41.3793% (minimum 75%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 70%, Baseline (adaptation disabled)); hypothalamus: 60.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 63.1579% (minimum 75%, Baseline (adaptation disabled))",0.15,-0.0333333,-0.336207,0,1,partial,1.7,0.6,0.3,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171094,ALK,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 98.9691% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing)",-0.15,0.03,-0.000309278,0,80,unavailable,0.1,0,2.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171102,OBP2B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.15,0.3,0.239691,0,80,unavailable,0.1,0,2.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171102,OBP2B,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.15,0.3,0.239691,0,80,unavailable,0.1,0,2.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171102,OBP2B,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.15,0.3,0.239691,0,80,unavailable,0.1,0,2.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171102,OBP2B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.15,0.3,0.239691,0,80,unavailable,0.1,0,2.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171102,OBP2B,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 48.9130% (minimum 90%, Approved); adrenal gland: 56.2500% (minimum 99%, Missing); amygdala: 51.1364% (minimum 99%, Missing); basal ganglia: 49.4505% (minimum 99%, Missing); bone marrow: 77.5862% (minimum 98%, Approved); cerebellum: 37.1901% (minimum 98%, Approved); cerebral cortex: 40.5405% (minimum 98%, Approved); choroid plexus: 67.1642% (minimum 99%, Missing); colon: 53.5714% (minimum 97%, Missing); duodenum: 73.7705% (minimum 99%, Missing); esophagus: 69.2308% (minimum 97%, Missing); heart muscle: 56.9620% (minimum 99%, Missing); hippocampal formation: 45.0000% (minimum 99%, Missing); hypothalamus: 48.3871% (minimum 99%, Missing); kidney: 49.4505% (minimum 99%, Missing); liver: 45.4545% (minimum 99%, Missing); lung: 60.8108% (minimum 98%, Approved); lymph node: 65.2174% (minimum 95%, Approved); midbrain: 48.3871% (minimum 99%, Missing); pancreas: 46.8750% (minimum 99%, Missing); parathyroid gland: 77.5862% (minimum 95%, Approved); pituitary gland: 58.4416% (minimum 99%, Missing); rectum: 72.5806% (minimum 97%, Missing); retina: 61.6438% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 95%, Approved); skeletal muscle: 77.5862% (minimum 98%, Approved); skin: 66.1765% (minimum 95%, Missing); small intestine: 56.9620% (minimum 99%, Missing); smooth muscle: 76.2712% (minimum 98%, Approved); spinal cord: 52.9412% (minimum 99%, Missing); spleen: 38.1356% (minimum 90%, Approved); stomach: 55.5556% (minimum 97%, Missing); thymus: 80.3571% (minimum 95%, Missing); thyroid gland: 59.2105% (minimum 90%, Approved); tongue: 88.2353% (minimum 97%, Missing); urinary bladder: 55.5556% (minimum 97%, Missing)",-0.518644,-0.434286,-0.608099,0,3,partial,7.6,3.9,7.3,"cerebellum: 7.6 nTPM (vital, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 2); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); stomach: 3.6 nTPM (protected, limit 2); urinary bladder: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171121,KCNMB3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 48.9130% (minimum 60%, Approved); adrenal gland: 56.2500% (minimum 75%, Missing); amygdala: 51.1364% (minimum 75%, Missing); basal ganglia: 49.4505% (minimum 75%, Missing); cerebellum: 37.1901% (minimum 70%, Approved); cerebral cortex: 40.5405% (minimum 70%, Approved); choroid plexus: 67.1642% (minimum 75%, Missing); colon: 53.5714% (minimum 70%, Missing); duodenum: 73.7705% (minimum 75%, Missing); esophagus: 69.2308% (minimum 70%, Missing); heart muscle: 56.9620% (minimum 75%, Missing); hippocampal formation: 45.0000% (minimum 75%, Missing); hypothalamus: 48.3871% (minimum 75%, Missing); kidney: 49.4505% (minimum 75%, Missing); liver: 45.4545% (minimum 75%, Missing); lung: 60.8108% (minimum 70%, Approved); midbrain: 48.3871% (minimum 75%, Missing); pancreas: 46.8750% (minimum 75%, Missing); pituitary gland: 58.4416% (minimum 75%, Missing); retina: 61.6438% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 65%, Approved); small intestine: 56.9620% (minimum 75%, Missing); spinal cord: 52.9412% (minimum 75%, Missing); spleen: 38.1356% (minimum 60%, Approved); stomach: 55.5556% (minimum 70%, Missing); thyroid gland: 59.2105% (minimum 60%, Approved); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.218644,-0.164286,-0.328099,0,3,partial,7.6,3.9,7.3,"cerebellum: 7.6 nTPM (vital, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 2); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); stomach: 3.6 nTPM (protected, limit 2); urinary bladder: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171121,KCNMB3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 48.9130% (minimum 60%, Approved); adrenal gland: 56.2500% (minimum 75%, Missing); amygdala: 51.1364% (minimum 75%, Missing); basal ganglia: 49.4505% (minimum 75%, Missing); cerebellum: 37.1901% (minimum 70%, Approved); cerebral cortex: 40.5405% (minimum 70%, Approved); choroid plexus: 67.1642% (minimum 75%, Missing); colon: 53.5714% (minimum 70%, Missing); duodenum: 73.7705% (minimum 75%, Missing); esophagus: 69.2308% (minimum 70%, Missing); heart muscle: 56.9620% (minimum 75%, Missing); hippocampal formation: 45.0000% (minimum 75%, Missing); hypothalamus: 48.3871% (minimum 75%, Missing); kidney: 49.4505% (minimum 75%, Missing); liver: 45.4545% (minimum 75%, Missing); lung: 60.8108% (minimum 70%, Approved); midbrain: 48.3871% (minimum 75%, Missing); pancreas: 46.8750% (minimum 75%, Missing); pituitary gland: 58.4416% (minimum 75%, Missing); retina: 61.6438% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 65%, Approved); small intestine: 56.9620% (minimum 75%, Missing); spinal cord: 52.9412% (minimum 75%, Missing); spleen: 38.1356% (minimum 60%, Approved); stomach: 55.5556% (minimum 70%, Missing); thyroid gland: 59.2105% (minimum 60%, Approved); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.218644,-0.164286,-0.328099,0,3,partial,7.6,3.9,7.3,"cerebellum: 7.6 nTPM (vital, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 2); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 3); stomach: 3.6 nTPM (protected, limit 3); urinary bladder: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171121,KCNMB3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 48.9130% (minimum 60%, Approved); adrenal gland: 56.2500% (minimum 75%, Missing); amygdala: 51.1364% (minimum 75%, Missing); basal ganglia: 49.4505% (minimum 75%, Missing); cerebellum: 37.1901% (minimum 70%, Approved); cerebral cortex: 40.5405% (minimum 70%, Approved); choroid plexus: 67.1642% (minimum 75%, Missing); colon: 53.5714% (minimum 70%, Missing); duodenum: 73.7705% (minimum 75%, Missing); esophagus: 69.2308% (minimum 70%, Missing); heart muscle: 56.9620% (minimum 75%, Missing); hippocampal formation: 45.0000% (minimum 75%, Missing); hypothalamus: 48.3871% (minimum 75%, Missing); kidney: 49.4505% (minimum 75%, Missing); liver: 45.4545% (minimum 75%, Missing); lung: 60.8108% (minimum 70%, Approved); midbrain: 48.3871% (minimum 75%, Missing); pancreas: 46.8750% (minimum 75%, Missing); pituitary gland: 58.4416% (minimum 75%, Missing); retina: 61.6438% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 65%, Approved); small intestine: 56.9620% (minimum 75%, Missing); spinal cord: 52.9412% (minimum 75%, Missing); spleen: 38.1356% (minimum 60%, Approved); stomach: 55.5556% (minimum 70%, Missing); thyroid gland: 59.2105% (minimum 60%, Approved); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.218644,-0.164286,-0.328099,0,3,partial,7.6,3.9,7.3,"cerebellum: 7.6 nTPM (vital, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 2); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 3); stomach: 3.6 nTPM (protected, limit 3); urinary bladder: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171121,KCNMB3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 48.9130% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 56.2500% (minimum 75%, Baseline (adaptation disabled)); amygdala: 51.1364% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 49.4505% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 37.1901% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 40.5405% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.1642% (minimum 75%, Baseline (adaptation disabled)); colon: 53.5714% (minimum 70%, Baseline (adaptation disabled)); duodenum: 73.7705% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.2308% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 56.9620% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 45.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 48.3871% (minimum 75%, Baseline (adaptation disabled)); kidney: 49.4505% (minimum 75%, Baseline (adaptation disabled)); liver: 45.4545% (minimum 75%, Baseline (adaptation disabled)); lung: 60.8108% (minimum 75%, Baseline (adaptation disabled)); lymph node: 65.2174% (minimum 70%, Baseline (adaptation disabled)); midbrain: 48.3871% (minimum 75%, Baseline (adaptation disabled)); pancreas: 46.8750% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 58.4416% (minimum 75%, Baseline (adaptation disabled)); retina: 61.6438% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); small intestine: 56.9620% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 52.9412% (minimum 75%, Baseline (adaptation disabled)); spleen: 38.1356% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.5556% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 59.2105% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 55.5556% (minimum 70%, Baseline (adaptation disabled))",-0.268644,-0.164286,-0.378099,0,3,partial,7.6,3.9,7.3,"cerebellum: 7.6 nTPM (vital, limit 1); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 3); stomach: 3.6 nTPM (protected, limit 3); urinary bladder: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171121,KCNMB3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 66.6667% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 50.0000% (minimum 99%, Missing); midbrain: 28.5714% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing); skeletal muscle: 28.5714% (minimum 99%, Missing); spinal cord: 20.0000% (minimum 99%, Missing)",0.05,0.03,-0.79,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171133,OR2K2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 66.6667% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); midbrain: 28.5714% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); skeletal muscle: 28.5714% (minimum 75%, Missing); spinal cord: 20.0000% (minimum 75%, Missing)",0.35,0.3,-0.55,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171133,OR2K2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 66.6667% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); midbrain: 28.5714% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); skeletal muscle: 28.5714% (minimum 75%, Missing); spinal cord: 20.0000% (minimum 75%, Missing)",0.35,0.3,-0.55,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171133,OR2K2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 66.6667% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); midbrain: 28.5714% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); skeletal muscle: 28.5714% (minimum 75%, Missing); spinal cord: 20.0000% (minimum 75%, Missing)",0.35,0.3,-0.55,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171133,OR2K2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 66.6667% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 50.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 28.5714% (minimum 75%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 28.5714% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 20.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.55,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171133,OR2K2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0497149,0.03,0.01,0,2,partial,0.1,65.7,0.1,"salivary gland: 65.7 nTPM (protected, limit 12)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171209,CSN3,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349715,0.292219,0.25,0,2,partial,0.1,65.7,0.1,"salivary gland: 65.7 nTPM (protected, limit 12)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171209,CSN3,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349715,0.292219,0.25,0,2,partial,0.1,65.7,0.1,"salivary gland: 65.7 nTPM (protected, limit 12)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171209,CSN3,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349715,0.292219,0.25,0,2,partial,0.1,65.7,0.1,"salivary gland: 65.7 nTPM (protected, limit 12)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171209,CSN3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349715,0.142219,0.249715,0,2,partial,0.1,65.7,0.1,"salivary gland: 65.7 nTPM (protected, limit 3)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171209,CSN3,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.8033% (minimum 95%, Missing); adrenal gland: 93.3333% (minimum 99%, Missing); bone marrow: 48.6957% (minimum 99%, Missing); cerebral cortex: 94.9153% (minimum 99%, Missing); colon: 60.8696% (minimum 97%, Missing); duodenum: 34.3558% (minimum 99%, Missing); esophagus: 70.8861% (minimum 97%, Missing); heart muscle: 96.5517% (minimum 99%, Missing); hippocampal formation: 98.2456% (minimum 99%, Missing); kidney: 98.2456% (minimum 99%, Missing); liver: 90.3226% (minimum 99%, Missing); lung: 93.3333% (minimum 99%, Missing); lymph node: 55.4455% (minimum 97%, Missing); midbrain: 98.2456% (minimum 99%, Missing); pancreas: 86.1538% (minimum 99%, Missing); parathyroid gland: 94.9153% (minimum 97%, Missing); rectum: 57.7320% (minimum 97%, Missing); retina: 91.8033% (minimum 99%, Missing); salivary gland: 94.9153% (minimum 97%, Missing); skin: 84.8485% (minimum 95%, Missing); small intestine: 42.4242% (minimum 99%, Missing); smooth muscle: 88.8889% (minimum 99%, Missing); spinal cord: 98.2456% (minimum 99%, Missing); spleen: 88.8889% (minimum 95%, Missing); stomach: 69.1358% (minimum 97%, Missing); thymus: 40.2878% (minimum 95%, Missing); thyroid gland: 94.9153% (minimum 95%, Missing); tongue: 96.5517% (minimum 97%, Missing); urinary bladder: 87.5000% (minimum 97%, Missing)",-0.547122,-0.415545,-0.646442,0,80,unavailable,10.7,4.5,8.3,"duodenum: 10.7 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); rectum: 4.1 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171320,ESCO2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.6957% (minimum 75%, Missing); colon: 60.8696% (minimum 70%, Missing); duodenum: 34.3558% (minimum 75%, Missing); lymph node: 55.4455% (minimum 70%, Missing); rectum: 57.7320% (minimum 70%, Missing); small intestine: 42.4242% (minimum 75%, Missing); stomach: 69.1358% (minimum 70%, Missing); thymus: 40.2878% (minimum 65%, Missing)",-0.247122,-0.145545,-0.406442,0,80,unavailable,10.7,4.5,8.3,"duodenum: 10.7 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); rectum: 4.1 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171320,ESCO2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.6957% (minimum 75%, Missing); colon: 60.8696% (minimum 70%, Missing); duodenum: 34.3558% (minimum 75%, Missing); lymph node: 55.4455% (minimum 70%, Missing); rectum: 57.7320% (minimum 70%, Missing); small intestine: 42.4242% (minimum 75%, Missing); stomach: 69.1358% (minimum 70%, Missing); thymus: 40.2878% (minimum 65%, Missing)",-0.247122,-0.145545,-0.406442,0,80,unavailable,10.7,4.5,8.3,"duodenum: 10.7 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); rectum: 4.1 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171320,ESCO2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.6957% (minimum 75%, Missing); colon: 60.8696% (minimum 70%, Missing); duodenum: 34.3558% (minimum 75%, Missing); lymph node: 55.4455% (minimum 70%, Missing); rectum: 57.7320% (minimum 70%, Missing); small intestine: 42.4242% (minimum 75%, Missing); stomach: 69.1358% (minimum 70%, Missing); thymus: 40.2878% (minimum 65%, Missing)",-0.247122,-0.145545,-0.406442,0,80,unavailable,10.7,4.5,8.3,"duodenum: 10.7 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); rectum: 4.1 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171320,ESCO2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.6957% (minimum 75%, Baseline (adaptation disabled)); colon: 60.8696% (minimum 70%, Baseline (adaptation disabled)); duodenum: 34.3558% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.4455% (minimum 70%, Baseline (adaptation disabled)); rectum: 57.7320% (minimum 70%, Baseline (adaptation disabled)); small intestine: 42.4242% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.1358% (minimum 70%, Baseline (adaptation disabled)); thymus: 40.2878% (minimum 65%, Baseline (adaptation disabled))",-0.247122,-0.145545,-0.406442,0,80,unavailable,10.7,4.5,8.3,"duodenum: 10.7 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); rectum: 4.1 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171320,ESCO2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,0,routine_complete,1.9,0.3,3,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171402,XAGE3,admission_only,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,1.9,0.3,3,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171402,XAGE3,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,1.9,0.3,3,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171402,XAGE3,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,1.9,0.3,3,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171402,XAGE3,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34192,0.299186,0.244868,0,0,routine_complete,1.9,0.3,3,"liver: 1.9 nTPM (vital, limit 1)",,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171402,XAGE3,current_fixed,True,False,False,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016"
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171405,XAGE5,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171405,XAGE5,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171405,XAGE5,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171405,XAGE5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171405,XAGE5,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 98.7234% (minimum 99%, Missing)",0.05,0.03,-0.00276596,0,1,partial,0.3,0.2,0.2,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000171478,SPACA5B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.237234,0,1,partial,0.3,0.2,0.2,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000171478,SPACA5B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.237234,0,1,partial,0.3,0.2,0.2,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000171478,SPACA5B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.237234,0,1,partial,0.3,0.2,0.2,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000171478,SPACA5B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.341453,0.291453,0.237234,0,1,partial,0.3,0.2,0.2,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000171478,SPACA5B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171481,OR1L3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171481,OR1L3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171481,OR1L3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171481,OR1L3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171481,OR1L3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 22.7758% (minimum 97%, Missing)",0.05,-0.742242,0.01,0,80,unavailable,0,21.7,0,"parathyroid gland: 21.7 nTPM (protected, limit 2)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171487,NLRP5,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 22.7758% (minimum 70%, Missing)",0.35,-0.472242,0.25,0,80,unavailable,0,21.7,0,"parathyroid gland: 21.7 nTPM (protected, limit 2)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171487,NLRP5,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 22.7758% (minimum 70%, Missing)",0.35,-0.472242,0.25,0,80,unavailable,0,21.7,0,"parathyroid gland: 21.7 nTPM (protected, limit 3)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171487,NLRP5,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 22.7758% (minimum 70%, Missing)",0.35,-0.472242,0.25,0,80,unavailable,0,21.7,0,"parathyroid gland: 21.7 nTPM (protected, limit 3)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171487,NLRP5,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 22.7758% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.472242,0.25,0,80,unavailable,0,21.7,0,"parathyroid gland: 21.7 nTPM (protected, limit 3)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171487,NLRP5,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.8571% (minimum 99%, Missing); basal ganglia: 97.8571% (minimum 99%, Missing); hippocampal formation: 98.5612% (minimum 99%, Missing); hypothalamus: 97.8571% (minimum 99%, Missing); midbrain: 97.1631% (minimum 99%, Missing); retina: 97.1631% (minimum 99%, Missing); spinal cord: 98.5612% (minimum 99%, Missing)",0.0427536,0.03,-0.0183688,0,1,partial,0.4,0.2,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171489,SPACA5,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.342754,0.3,0.221631,0,1,partial,0.4,0.2,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171489,SPACA5,selectivity_revised,True,False,True,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.342754,0.3,0.221631,0,1,partial,0.4,0.2,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171489,SPACA5,grid_revised,True,False,True,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.342754,0.3,0.221631,0,1,partial,0.4,0.2,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171489,SPACA5,current_adaptive,True,False,True,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.314789,0.285612,0.221631,0,1,partial,0.4,0.2,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171489,SPACA5,current_fixed,True,False,True,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.6813% (minimum 95%, Missing); adrenal gland: 32.4675% (minimum 99%, Missing); amygdala: 45.4545% (minimum 99%, Missing); basal ganglia: 42.2297% (minimum 99%, Missing); bone marrow: 47.1698% (minimum 99%, Missing); cerebellum: 60.3865% (minimum 99%, Missing); cerebral cortex: 37.6506% (minimum 99%, Missing); choroid plexus: 61.8812% (minimum 99%, Missing); colon: 41.9463% (minimum 97%, Missing); duodenum: 40.3226% (minimum 99%, Missing); esophagus: 62.1891% (minimum 97%, Missing); heart muscle: 63.1313% (minimum 99%, Missing); hippocampal formation: 33.4225% (minimum 99%, Missing); hypothalamus: 42.6621% (minimum 99%, Missing); kidney: 33.3333% (minimum 99%, Missing); liver: 35.4108% (minimum 99%, Missing); lung: 56.8182% (minimum 99%, Missing); lymph node: 33.9674% (minimum 97%, Missing); midbrain: 36.6569% (minimum 99%, Missing); pancreas: 49.8008% (minimum 99%, Missing); parathyroid gland: 62.8141% (minimum 97%, Missing); pituitary gland: 44.1696% (minimum 99%, Missing); rectum: 41.5282% (minimum 97%, Missing); retina: 51.8672% (minimum 99%, Missing); salivary gland: 34.4353% (minimum 97%, Missing); skeletal muscle: 60.0962% (minimum 99%, Missing); skin: 69.4444% (minimum 95%, Missing); small intestine: 41.6667% (minimum 99%, Missing); smooth muscle: 53.1915% (minimum 99%, Missing); spinal cord: 22.7273% (minimum 99%, Missing); spleen: 34.9162% (minimum 95%, Missing); stomach: 52.7426% (minimum 97%, Missing); thymus: 31.6456% (minimum 95%, Missing); thyroid gland: 44.8029% (minimum 95%, Missing); tongue: 79.1139% (minimum 97%, Missing); urinary bladder: 53.6481% (minimum 97%, Missing)",-0.633544,-0.630326,-0.762727,0,80,unavailable,42.5,24.3,27,"spinal cord: 42.5 nTPM (vital, limit 1); thymus: 27 nTPM (manageable, limit 5); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 2); salivary gland: 23.8 nTPM (protected, limit 2); spleen: 23.3 nTPM (manageable, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 2); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 2); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (manageable, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 2); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 3.3 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171492,LRRC8D,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 32.4675% (minimum 75%, Missing); amygdala: 45.4545% (minimum 75%, Missing); basal ganglia: 42.2297% (minimum 75%, Missing); bone marrow: 47.1698% (minimum 75%, Missing); cerebellum: 60.3865% (minimum 75%, Missing); cerebral cortex: 37.6506% (minimum 75%, Missing); choroid plexus: 61.8812% (minimum 75%, Missing); colon: 41.9463% (minimum 70%, Missing); duodenum: 40.3226% (minimum 75%, Missing); esophagus: 62.1891% (minimum 70%, Missing); heart muscle: 63.1313% (minimum 75%, Missing); hippocampal formation: 33.4225% (minimum 75%, Missing); hypothalamus: 42.6621% (minimum 75%, Missing); kidney: 33.3333% (minimum 75%, Missing); liver: 35.4108% (minimum 75%, Missing); lung: 56.8182% (minimum 75%, Missing); lymph node: 33.9674% (minimum 70%, Missing); midbrain: 36.6569% (minimum 75%, Missing); pancreas: 49.8008% (minimum 75%, Missing); parathyroid gland: 62.8141% (minimum 70%, Missing); pituitary gland: 44.1696% (minimum 75%, Missing); rectum: 41.5282% (minimum 70%, Missing); retina: 51.8672% (minimum 75%, Missing); salivary gland: 34.4353% (minimum 70%, Missing); skeletal muscle: 60.0962% (minimum 75%, Missing); small intestine: 41.6667% (minimum 75%, Missing); smooth muscle: 53.1915% (minimum 75%, Missing); spinal cord: 22.7273% (minimum 75%, Missing); spleen: 34.9162% (minimum 65%, Missing); stomach: 52.7426% (minimum 70%, Missing); thymus: 31.6456% (minimum 65%, Missing); thyroid gland: 44.8029% (minimum 65%, Missing); urinary bladder: 53.6481% (minimum 70%, Missing)",-0.333544,-0.360326,-0.522727,0,80,unavailable,42.5,24.3,27,"spinal cord: 42.5 nTPM (vital, limit 1); thymus: 27 nTPM (manageable, limit 5); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 2); salivary gland: 23.8 nTPM (protected, limit 2); spleen: 23.3 nTPM (manageable, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 2); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 2); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (manageable, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 2); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 3.3 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171492,LRRC8D,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 32.4675% (minimum 75%, Missing); amygdala: 45.4545% (minimum 75%, Missing); basal ganglia: 42.2297% (minimum 75%, Missing); bone marrow: 47.1698% (minimum 75%, Missing); cerebellum: 60.3865% (minimum 75%, Missing); cerebral cortex: 37.6506% (minimum 75%, Missing); choroid plexus: 61.8812% (minimum 75%, Missing); colon: 41.9463% (minimum 70%, Missing); duodenum: 40.3226% (minimum 75%, Missing); esophagus: 62.1891% (minimum 70%, Missing); heart muscle: 63.1313% (minimum 75%, Missing); hippocampal formation: 33.4225% (minimum 75%, Missing); hypothalamus: 42.6621% (minimum 75%, Missing); kidney: 33.3333% (minimum 75%, Missing); liver: 35.4108% (minimum 75%, Missing); lung: 56.8182% (minimum 75%, Missing); lymph node: 33.9674% (minimum 70%, Missing); midbrain: 36.6569% (minimum 75%, Missing); pancreas: 49.8008% (minimum 75%, Missing); parathyroid gland: 62.8141% (minimum 70%, Missing); pituitary gland: 44.1696% (minimum 75%, Missing); rectum: 41.5282% (minimum 70%, Missing); retina: 51.8672% (minimum 75%, Missing); salivary gland: 34.4353% (minimum 70%, Missing); skeletal muscle: 60.0962% (minimum 75%, Missing); small intestine: 41.6667% (minimum 75%, Missing); smooth muscle: 53.1915% (minimum 75%, Missing); spinal cord: 22.7273% (minimum 75%, Missing); spleen: 34.9162% (minimum 65%, Missing); stomach: 52.7426% (minimum 70%, Missing); thymus: 31.6456% (minimum 65%, Missing); thyroid gland: 44.8029% (minimum 65%, Missing); urinary bladder: 53.6481% (minimum 70%, Missing)",-0.333544,-0.360326,-0.522727,0,80,unavailable,42.5,24.3,27,"spinal cord: 42.5 nTPM (vital, limit 1); thymus: 27 nTPM (manageable, limit 5); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 3); salivary gland: 23.8 nTPM (protected, limit 3); spleen: 23.3 nTPM (manageable, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 3); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 3); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (manageable, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 3); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 3); parathyroid gland: 7.4 nTPM (protected, limit 3); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 3.3 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171492,LRRC8D,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 32.4675% (minimum 75%, Missing); amygdala: 45.4545% (minimum 75%, Missing); basal ganglia: 42.2297% (minimum 75%, Missing); bone marrow: 47.1698% (minimum 75%, Missing); cerebellum: 60.3865% (minimum 75%, Missing); cerebral cortex: 37.6506% (minimum 75%, Missing); choroid plexus: 61.8812% (minimum 75%, Missing); colon: 41.9463% (minimum 70%, Missing); duodenum: 40.3226% (minimum 75%, Missing); esophagus: 62.1891% (minimum 70%, Missing); heart muscle: 63.1313% (minimum 75%, Missing); hippocampal formation: 33.4225% (minimum 75%, Missing); hypothalamus: 42.6621% (minimum 75%, Missing); kidney: 33.3333% (minimum 75%, Missing); liver: 35.4108% (minimum 75%, Missing); lung: 56.8182% (minimum 75%, Missing); lymph node: 33.9674% (minimum 70%, Missing); midbrain: 36.6569% (minimum 75%, Missing); pancreas: 49.8008% (minimum 75%, Missing); parathyroid gland: 62.8141% (minimum 70%, Missing); pituitary gland: 44.1696% (minimum 75%, Missing); rectum: 41.5282% (minimum 70%, Missing); retina: 51.8672% (minimum 75%, Missing); salivary gland: 34.4353% (minimum 70%, Missing); skeletal muscle: 60.0962% (minimum 75%, Missing); small intestine: 41.6667% (minimum 75%, Missing); smooth muscle: 53.1915% (minimum 75%, Missing); spinal cord: 22.7273% (minimum 75%, Missing); spleen: 34.9162% (minimum 65%, Missing); stomach: 52.7426% (minimum 70%, Missing); thymus: 31.6456% (minimum 65%, Missing); thyroid gland: 44.8029% (minimum 65%, Missing); urinary bladder: 53.6481% (minimum 70%, Missing)",-0.333544,-0.360326,-0.522727,0,80,unavailable,42.5,24.3,27,"spinal cord: 42.5 nTPM (vital, limit 1); thymus: 27 nTPM (manageable, limit 5); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 3); salivary gland: 23.8 nTPM (protected, limit 3); spleen: 23.3 nTPM (manageable, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 3); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 3); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (manageable, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 3); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 3); parathyroid gland: 7.4 nTPM (protected, limit 3); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 3.3 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171492,LRRC8D,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 32.4675% (minimum 75%, Baseline (adaptation disabled)); amygdala: 45.4545% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 42.2297% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 47.1698% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.3865% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 37.6506% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 61.8812% (minimum 75%, Baseline (adaptation disabled)); colon: 41.9463% (minimum 70%, Baseline (adaptation disabled)); duodenum: 40.3226% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.1891% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.1313% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 33.4225% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 42.6621% (minimum 75%, Baseline (adaptation disabled)); kidney: 33.3333% (minimum 75%, Baseline (adaptation disabled)); liver: 35.4108% (minimum 75%, Baseline (adaptation disabled)); lung: 56.8182% (minimum 75%, Baseline (adaptation disabled)); lymph node: 33.9674% (minimum 70%, Baseline (adaptation disabled)); midbrain: 36.6569% (minimum 75%, Baseline (adaptation disabled)); pancreas: 49.8008% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.8141% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 44.1696% (minimum 75%, Baseline (adaptation disabled)); rectum: 41.5282% (minimum 70%, Baseline (adaptation disabled)); retina: 51.8672% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 34.4353% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.0962% (minimum 75%, Baseline (adaptation disabled)); small intestine: 41.6667% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.1915% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 22.7273% (minimum 75%, Baseline (adaptation disabled)); spleen: 34.9162% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.7426% (minimum 70%, Baseline (adaptation disabled)); thymus: 31.6456% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 44.8029% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 53.6481% (minimum 70%, Baseline (adaptation disabled))",-0.333544,-0.360326,-0.522727,0,80,unavailable,42.5,24.3,27,"spinal cord: 42.5 nTPM (vital, limit 1); thymus: 27 nTPM (manageable, limit 5); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 3); salivary gland: 23.8 nTPM (protected, limit 3); spleen: 23.3 nTPM (manageable, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 3); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 3); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (manageable, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 3); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 3); parathyroid gland: 7.4 nTPM (protected, limit 3); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 3.3 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171492,LRRC8D,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0.1,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171495,MROH2B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171495,MROH2B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171495,MROH2B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171495,MROH2B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296599,0.25,0,1,partial,0,0.1,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171495,MROH2B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 33.3333% (minimum 99%, Missing)",0.05,0.03,-0.656667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171505,OR1N1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171505,OR1N1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171505,OR1N1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171505,OR1N1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 33.3333% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171505,OR1N1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.1661% (minimum 95%, Enhanced); amygdala: 36.9606% (minimum 99%, Missing); basal ganglia: 34.3206% (minimum 99%, Missing); cerebellum: 47.5845% (minimum 99%, Missing); cerebral cortex: 31.6975% (minimum 99%, Missing); choroid plexus: 30.6854% (minimum 99%, Missing); colon: 63.9610% (minimum 97%, Missing); duodenum: 96.0976% (minimum 99%, Missing); heart muscle: 82.5996% (minimum 95%, Enhanced); hippocampal formation: 38.1783% (minimum 99%, Missing); hypothalamus: 34.2609% (minimum 99%, Missing); kidney: 70.4830% (minimum 99%, Missing); lung: 84.0085% (minimum 95%, Enhanced); midbrain: 45.2354% (minimum 99%, Missing); pancreas: 91.8415% (minimum 95%, Enhanced); parathyroid gland: 64.9094% (minimum 80%, Enhanced); pituitary gland: 34.5009% (minimum 99%, Missing); rectum: 92.0561% (minimum 97%, Missing); retina: 29.7358% (minimum 99%, Missing); skin: 83.4746% (minimum 95%, Missing); small intestine: 89.5455% (minimum 99%, Missing); smooth muscle: 75.7692% (minimum 95%, Enhanced); spinal cord: 47.5271% (minimum 99%, Missing); stomach: 79.2757% (minimum 80%, Enhanced)",-0.115254,-0.33039,-0.692642,0,17,partial,93.1,22.2,7.8,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 2); parathyroid gland: 21.3 nTPM (protected, limit 12); adrenal gland: 18.4 nTPM (vital, limit 6); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 6); heart muscle: 8.3 nTPM (vital, limit 6); skin: 7.8 nTPM (manageable, limit 5); lung: 7.5 nTPM (vital, limit 6); small intestine: 4.6 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / eccrine glands: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),123,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / eccrine glands; skin 1 / hair follicles; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / eccrine glands; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171533,MAP6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 36.9606% (minimum 75%, Missing); basal ganglia: 34.3206% (minimum 75%, Missing); cerebellum: 47.5845% (minimum 75%, Missing); cerebral cortex: 31.6975% (minimum 75%, Missing); choroid plexus: 30.6854% (minimum 75%, Missing); colon: 63.9610% (minimum 70%, Missing); hippocampal formation: 38.1783% (minimum 75%, Missing); hypothalamus: 34.2609% (minimum 75%, Missing); kidney: 70.4830% (minimum 75%, Missing); midbrain: 45.2354% (minimum 75%, Missing); pituitary gland: 34.5009% (minimum 75%, Missing); retina: 29.7358% (minimum 75%, Missing); spinal cord: 47.5271% (minimum 75%, Missing)",0.184746,-0.0603896,-0.452642,0,17,partial,93.1,22.2,7.8,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 2); parathyroid gland: 21.3 nTPM (protected, limit 12); adrenal gland: 18.4 nTPM (vital, limit 6); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 6); heart muscle: 8.3 nTPM (vital, limit 6); skin: 7.8 nTPM (manageable, limit 5); lung: 7.5 nTPM (vital, limit 6); small intestine: 4.6 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / eccrine glands: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),123,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / eccrine glands; skin 1 / hair follicles; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / eccrine glands; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171533,MAP6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 36.9606% (minimum 75%, Missing); basal ganglia: 34.3206% (minimum 75%, Missing); cerebellum: 47.5845% (minimum 75%, Missing); cerebral cortex: 31.6975% (minimum 75%, Missing); choroid plexus: 30.6854% (minimum 75%, Missing); colon: 63.9610% (minimum 70%, Missing); hippocampal formation: 38.1783% (minimum 75%, Missing); hypothalamus: 34.2609% (minimum 75%, Missing); kidney: 70.4830% (minimum 75%, Missing); midbrain: 45.2354% (minimum 75%, Missing); pituitary gland: 34.5009% (minimum 75%, Missing); retina: 29.7358% (minimum 75%, Missing); spinal cord: 47.5271% (minimum 75%, Missing)",0.184746,-0.0603896,-0.452642,0,17,partial,93.1,22.2,7.8,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 3); parathyroid gland: 21.3 nTPM (protected, limit 12); adrenal gland: 18.4 nTPM (vital, limit 6); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 6); heart muscle: 8.3 nTPM (vital, limit 6); skin: 7.8 nTPM (manageable, limit 5); lung: 7.5 nTPM (vital, limit 6); small intestine: 4.6 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / eccrine glands: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),123,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / eccrine glands; skin 1 / hair follicles; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / eccrine glands; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171533,MAP6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 36.9606% (minimum 75%, Missing); basal ganglia: 34.3206% (minimum 75%, Missing); cerebellum: 47.5845% (minimum 75%, Missing); cerebral cortex: 31.6975% (minimum 75%, Missing); choroid plexus: 30.6854% (minimum 75%, Missing); colon: 63.9610% (minimum 70%, Missing); hippocampal formation: 38.1783% (minimum 75%, Missing); hypothalamus: 34.2609% (minimum 75%, Missing); kidney: 70.4830% (minimum 75%, Missing); midbrain: 45.2354% (minimum 75%, Missing); pituitary gland: 34.5009% (minimum 75%, Missing); retina: 29.7358% (minimum 75%, Missing); spinal cord: 47.5271% (minimum 75%, Missing)",0.184746,-0.0603896,-0.452642,0,17,partial,93.1,22.2,7.8,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 3); parathyroid gland: 21.3 nTPM (protected, limit 12); adrenal gland: 18.4 nTPM (vital, limit 6); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 6); heart muscle: 8.3 nTPM (vital, limit 6); skin: 7.8 nTPM (manageable, limit 5); lung: 7.5 nTPM (vital, limit 6); small intestine: 4.6 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / eccrine glands: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),123,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / eccrine glands; skin 1 / hair follicles; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / eccrine glands; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171533,MAP6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.1661% (minimum 75%, Baseline (adaptation disabled)); amygdala: 36.9606% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 34.3206% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 47.5845% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 31.6975% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 30.6854% (minimum 75%, Baseline (adaptation disabled)); colon: 63.9610% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 38.1783% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 34.2609% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.4830% (minimum 75%, Baseline (adaptation disabled)); midbrain: 45.2354% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.9094% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 34.5009% (minimum 75%, Baseline (adaptation disabled)); retina: 29.7358% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 47.5271% (minimum 75%, Baseline (adaptation disabled))",0.184746,-0.0603896,-0.452642,0,17,partial,93.1,22.2,7.8,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 3); parathyroid gland: 21.3 nTPM (protected, limit 3); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 3); heart muscle: 8.3 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); thyroid gland: 7.6 nTPM (manageable, limit 5); lung: 7.5 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 3); small intestine: 4.6 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 3); pancreas: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / eccrine glands: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),123,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / eccrine glands; skin 1 / hair follicles; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / eccrine glands; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171533,MAP6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 50.0000% (minimum 99%, Missing); hypothalamus: 1.5267% (minimum 99%, Missing); lung: 66.6667% (minimum 95%, Enhanced); midbrain: 50.0000% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing)",0.05,0.03,-0.974733,0,3,partial,12.9,0,0,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171540,OTP,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 50.0000% (minimum 75%, Missing); hypothalamus: 1.5267% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.734733,0,3,partial,12.9,0,0,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171540,OTP,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 50.0000% (minimum 75%, Missing); hypothalamus: 1.5267% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.734733,0,3,partial,12.9,0,0,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171540,OTP,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 50.0000% (minimum 75%, Missing); hypothalamus: 1.5267% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.734733,0,3,partial,12.9,0,0,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171540,OTP,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 1.5267% (minimum 75%, Baseline (adaptation disabled)); lung: 66.6667% (minimum 75%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.734733,0,3,partial,12.9,0,0,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171540,OTP,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.6627% (minimum 99%, Missing); cerebellum: 98.6885% (minimum 99%, Missing); liver: 98.6885% (minimum 99%, Missing); pituitary gland: 98.0456% (minimum 99%, Missing); retina: 92.9012% (minimum 99%, Missing)",0.0433993,0.0201316,-0.0833735,0,80,unavailable,3.1,0.3,0.2,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171722,SPATA46,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343399,0.290132,0.156627,0,80,unavailable,3.1,0.3,0.2,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171722,SPATA46,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343399,0.290132,0.156627,0,80,unavailable,3.1,0.3,0.2,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171722,SPATA46,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343399,0.290132,0.156627,0,80,unavailable,3.1,0.3,0.2,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171722,SPATA46,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343399,0.290132,0.156627,0,80,unavailable,3.1,0.3,0.2,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171722,SPATA46,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.2086% (minimum 90%, Approved); adrenal gland: 97.6378% (minimum 99%, Missing); amygdala: 86.7133% (minimum 99%, Missing); basal ganglia: 84.3537% (minimum 99%, Missing); bone marrow: 89.8551% (minimum 99%, Missing); cerebellum: 98.4127% (minimum 99%, Missing); cerebral cortex: 87.3239% (minimum 99%, Missing); choroid plexus: 68.8889% (minimum 99%, Missing); colon: 96.8750% (minimum 97%, Missing); duodenum: 98.4127% (minimum 99%, Missing); heart muscle: 91.8519% (minimum 98%, Approved); hippocampal formation: 88.5714% (minimum 99%, Missing); hypothalamus: 85.5172% (minimum 99%, Missing); kidney: 94.6565% (minimum 99%, Missing); lung: 92.5373% (minimum 98%, Approved); lymph node: 93.9394% (minimum 95%, Approved); midbrain: 87.3239% (minimum 99%, Missing); pituitary gland: 82.1192% (minimum 99%, Missing); retina: 69.6629% (minimum 99%, Missing); skeletal muscle: 97.6378% (minimum 98%, Approved); small intestine: 96.8750% (minimum 99%, Missing); spinal cord: 86.7133% (minimum 99%, Missing); stomach: 96.8750% (minimum 97%, Missing); thyroid gland: 93.2331% (minimum 95%, Missing); tongue: 96.8750% (minimum 97%, Missing); urinary bladder: 96.8750% (minimum 97%, Missing)",-0.0176692,-0.0106061,-0.301111,0,6,partial,5.6,0.8,1.5,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171757,LRRC34,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 68.8889% (minimum 75%, Missing); retina: 69.6629% (minimum 75%, Missing)",0.282331,0.26875,-0.0611111,0,6,partial,5.6,0.8,1.5,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171757,LRRC34,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 68.8889% (minimum 75%, Missing); retina: 69.6629% (minimum 75%, Missing)",0.282331,0.26875,-0.0611111,0,6,partial,5.6,0.8,1.5,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171757,LRRC34,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 68.8889% (minimum 75%, Missing); retina: 69.6629% (minimum 75%, Missing)",0.282331,0.26875,-0.0611111,0,6,partial,5.6,0.8,1.5,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171757,LRRC34,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 68.8889% (minimum 75%, Baseline (adaptation disabled)); retina: 69.6629% (minimum 75%, Baseline (adaptation disabled))",0.242086,0.239394,-0.0611111,0,6,partial,5.6,0.8,1.5,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171757,LRRC34,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 87.5476% (minimum 99%, Missing); basal ganglia: 86.0175% (minimum 99%, Missing); cerebellum: 79.7454% (minimum 95%, Enhanced); cerebral cortex: 80.8685% (minimum 95%, Enhanced); hippocampal formation: 88.5604% (minimum 99%, Missing); hypothalamus: 90.4199% (minimum 99%, Missing); liver: 94.6429% (minimum 95%, Enhanced); midbrain: 95.8275% (minimum 99%, Missing); pancreas: 94.9036% (minimum 95%, Enhanced); pituitary gland: 98.2882% (minimum 99%, Missing); retina: 96.9058% (minimum 99%, Missing); spinal cord: 94.5130% (minimum 99%, Missing)",0.0471056,0.00730496,-0.152546,0,1,partial,17.5,1.6,1.8,"cerebellum: 17.5 nTPM (vital, limit 6); cerebral cortex: 16.3 nTPM (vital, limit 6); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171772,SYCE1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347106,0.277305,0.110175,0,1,partial,17.5,1.6,1.8,"cerebellum: 17.5 nTPM (vital, limit 6); cerebral cortex: 16.3 nTPM (vital, limit 6); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171772,SYCE1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347106,0.277305,0.110175,0,1,partial,17.5,1.6,1.8,"cerebellum: 17.5 nTPM (vital, limit 6); cerebral cortex: 16.3 nTPM (vital, limit 6); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171772,SYCE1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347106,0.277305,0.110175,0,1,partial,17.5,1.6,1.8,"cerebellum: 17.5 nTPM (vital, limit 6); cerebral cortex: 16.3 nTPM (vital, limit 6); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171772,SYCE1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.32454,0.277305,0.0474537,0,1,partial,17.5,1.6,1.8,"cerebellum: 17.5 nTPM (vital, limit 1); cerebral cortex: 16.3 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171772,SYCE1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 98.5333% (minimum 99%, Missing); liver: 98.0106% (minimum 99%, Missing); lung: 97.3650% (minimum 99%, Missing); pituitary gland: 98.9290% (minimum 99%, Missing); salivary gland: 94.8652% (minimum 97%, Missing); small intestine: 98.5333% (minimum 99%, Missing)",0.0406166,-0.0213479,-0.0163505,0,80,unavailable,2,4,0.7,"salivary gland: 4 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171790,SLFNL1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340617,0.248652,0.22365,0,80,unavailable,2,4,0.7,"salivary gland: 4 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171790,SLFNL1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340617,0.248652,0.22365,0,80,unavailable,2,4,0.7,"salivary gland: 4 nTPM (protected, limit 3); lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171790,SLFNL1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340617,0.248652,0.22365,0,80,unavailable,2,4,0.7,"salivary gland: 4 nTPM (protected, limit 3); lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171790,SLFNL1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340617,0.248652,0.22365,0,80,unavailable,2,4,0.7,"salivary gland: 4 nTPM (protected, limit 3); lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171790,SLFNL1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.3051% (minimum 99%, Missing); pituitary gland: 98.3051% (minimum 99%, Missing)",0.05,0.03,-0.00694915,0,6,partial,0.1,0,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171794,UTF1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.233051,0,6,partial,0.1,0,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171794,UTF1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.233051,0,6,partial,0.1,0,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171794,UTF1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.233051,0,6,partial,0.1,0,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171794,UTF1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333051,0.3,0.233051,0,6,partial,0.1,0,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171794,UTF1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0321429,0.03,0.0039759,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171804,WDR87,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.332143,0.3,0.243976,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171804,WDR87,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.332143,0.3,0.243976,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171804,WDR87,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.332143,0.3,0.243976,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171804,WDR87,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.332143,0.3,0.243976,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171804,WDR87,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.3590% (minimum 95%, Missing); adrenal gland: 70.7317% (minimum 99%, Missing); amygdala: 72.5000% (minimum 99%, Missing); basal ganglia: 71.6049% (minimum 99%, Missing); bone marrow: 72.5000% (minimum 99%, Missing); cerebellum: 68.2353% (minimum 99%, Missing); cerebral cortex: 68.2353% (minimum 99%, Missing); choroid plexus: 77.3333% (minimum 99%, Missing); colon: 78.3784% (minimum 97%, Missing); duodenum: 76.3158% (minimum 99%, Missing); esophagus: 72.5000% (minimum 97%, Missing); heart muscle: 70.7317% (minimum 99%, Missing); hippocampal formation: 71.6049% (minimum 99%, Missing); hypothalamus: 71.6049% (minimum 99%, Missing); kidney: 68.2353% (minimum 99%, Missing); liver: 77.3333% (minimum 99%, Missing); lung: 74.3590% (minimum 99%, Missing); lymph node: 69.0476% (minimum 97%, Missing); midbrain: 68.2353% (minimum 99%, Missing); pancreas: 79.4521% (minimum 99%, Missing); parathyroid gland: 59.7938% (minimum 97%, Missing); pituitary gland: 77.3333% (minimum 99%, Missing); rectum: 84.0580% (minimum 97%, Missing); retina: 65.9091% (minimum 99%, Missing); salivary gland: 71.6049% (minimum 97%, Missing); skeletal muscle: 75.3247% (minimum 99%, Missing); skin: 77.3333% (minimum 95%, Missing); small intestine: 80.5556% (minimum 99%, Missing); smooth muscle: 72.5000% (minimum 99%, Missing); spinal cord: 63.0435% (minimum 99%, Missing); spleen: 71.6049% (minimum 95%, Uncertain); stomach: 74.3590% (minimum 97%, Missing); thymus: 71.6049% (minimum 95%, Missing); thyroid gland: 65.1685% (minimum 95%, Missing); tongue: 68.2353% (minimum 97%, Missing); urinary bladder: 75.3247% (minimum 97%, Missing)",-0.298315,-0.372062,-0.359565,0,2,partial,3.4,3.9,3.1,"parathyroid gland: 3.9 nTPM (protected, limit 2); spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); adrenal gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171827,ZNF570,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.7317% (minimum 75%, Missing); amygdala: 72.5000% (minimum 75%, Missing); basal ganglia: 71.6049% (minimum 75%, Missing); bone marrow: 72.5000% (minimum 75%, Missing); cerebellum: 68.2353% (minimum 75%, Missing); cerebral cortex: 68.2353% (minimum 75%, Missing); heart muscle: 70.7317% (minimum 75%, Missing); hippocampal formation: 71.6049% (minimum 75%, Missing); hypothalamus: 71.6049% (minimum 75%, Missing); kidney: 68.2353% (minimum 75%, Missing); lung: 74.3590% (minimum 75%, Missing); lymph node: 69.0476% (minimum 70%, Missing); midbrain: 68.2353% (minimum 75%, Missing); parathyroid gland: 59.7938% (minimum 70%, Missing); retina: 65.9091% (minimum 75%, Missing); smooth muscle: 72.5000% (minimum 75%, Missing); spinal cord: 63.0435% (minimum 75%, Missing); tongue: 68.2353% (minimum 70%, Missing)",0.00168539,-0.102062,-0.119565,0,2,partial,3.4,3.9,3.1,"parathyroid gland: 3.9 nTPM (protected, limit 2); spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); adrenal gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171827,ZNF570,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.7317% (minimum 75%, Missing); amygdala: 72.5000% (minimum 75%, Missing); basal ganglia: 71.6049% (minimum 75%, Missing); bone marrow: 72.5000% (minimum 75%, Missing); cerebellum: 68.2353% (minimum 75%, Missing); cerebral cortex: 68.2353% (minimum 75%, Missing); heart muscle: 70.7317% (minimum 75%, Missing); hippocampal formation: 71.6049% (minimum 75%, Missing); hypothalamus: 71.6049% (minimum 75%, Missing); kidney: 68.2353% (minimum 75%, Missing); lung: 74.3590% (minimum 75%, Missing); lymph node: 69.0476% (minimum 70%, Missing); midbrain: 68.2353% (minimum 75%, Missing); parathyroid gland: 59.7938% (minimum 70%, Missing); retina: 65.9091% (minimum 75%, Missing); smooth muscle: 72.5000% (minimum 75%, Missing); spinal cord: 63.0435% (minimum 75%, Missing); tongue: 68.2353% (minimum 70%, Missing)",0.00168539,-0.102062,-0.119565,0,2,partial,3.4,3.9,3.1,"parathyroid gland: 3.9 nTPM (protected, limit 3); spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171827,ZNF570,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.7317% (minimum 75%, Missing); amygdala: 72.5000% (minimum 75%, Missing); basal ganglia: 71.6049% (minimum 75%, Missing); bone marrow: 72.5000% (minimum 75%, Missing); cerebellum: 68.2353% (minimum 75%, Missing); cerebral cortex: 68.2353% (minimum 75%, Missing); heart muscle: 70.7317% (minimum 75%, Missing); hippocampal formation: 71.6049% (minimum 75%, Missing); hypothalamus: 71.6049% (minimum 75%, Missing); kidney: 68.2353% (minimum 75%, Missing); lung: 74.3590% (minimum 75%, Missing); lymph node: 69.0476% (minimum 70%, Missing); midbrain: 68.2353% (minimum 75%, Missing); parathyroid gland: 59.7938% (minimum 70%, Missing); retina: 65.9091% (minimum 75%, Missing); smooth muscle: 72.5000% (minimum 75%, Missing); spinal cord: 63.0435% (minimum 75%, Missing); tongue: 68.2353% (minimum 70%, Missing)",0.00168539,-0.102062,-0.119565,0,2,partial,3.4,3.9,3.1,"parathyroid gland: 3.9 nTPM (protected, limit 3); spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171827,ZNF570,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.7317% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.5000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.6049% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 72.5000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.2353% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.2353% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.7317% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.6049% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.6049% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.2353% (minimum 75%, Baseline (adaptation disabled)); lung: 74.3590% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.0476% (minimum 70%, Baseline (adaptation disabled)); midbrain: 68.2353% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.7938% (minimum 70%, Baseline (adaptation disabled)); retina: 65.9091% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.5000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.0435% (minimum 75%, Baseline (adaptation disabled)); tongue: 68.2353% (minimum 70%, Baseline (adaptation disabled))",0.00168539,-0.102062,-0.119565,0,2,partial,3.4,3.9,3.1,"parathyroid gland: 3.9 nTPM (protected, limit 3); spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171827,ZNF570,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Missing); adrenal gland: 52.6316% (minimum 99%, Missing); amygdala: 62.5000% (minimum 99%, Missing); basal ganglia: 50.0000% (minimum 99%, Missing); bone marrow: 86.9565% (minimum 99%, Missing); cerebellum: 47.6190% (minimum 99%, Missing); cerebral cortex: 22.7273% (minimum 99%, Missing); choroid plexus: 80.0000% (minimum 99%, Missing); colon: 83.3333% (minimum 97%, Missing); duodenum: 74.0741% (minimum 99%, Missing); esophagus: 64.5161% (minimum 97%, Missing); heart muscle: 57.1429% (minimum 99%, Missing); hippocampal formation: 60.6061% (minimum 99%, Missing); hypothalamus: 58.8235% (minimum 99%, Missing); kidney: 74.0741% (minimum 99%, Missing); liver: 95.2381% (minimum 99%, Missing); lung: 60.6061% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 60.6061% (minimum 99%, Missing); pancreas: 54.0541% (minimum 99%, Missing); parathyroid gland: 86.9565% (minimum 97%, Missing); pituitary gland: 52.6316% (minimum 99%, Missing); rectum: 90.9091% (minimum 97%, Missing); retina: 30.7692% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing); skeletal muscle: 74.0741% (minimum 99%, Missing); skin: 47.6190% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 68.9655% (minimum 95%, Missing); stomach: 76.9231% (minimum 97%, Missing); thyroid gland: 45.4545% (minimum 95%, Missing); urinary bladder: 83.3333% (minimum 97%, Missing)",-0.495455,-0.47,-0.762727,0,80,unavailable,6.8,2,2.4,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171847,FAM90A1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 52.6316% (minimum 75%, Missing); amygdala: 62.5000% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebellum: 47.6190% (minimum 75%, Missing); cerebral cortex: 22.7273% (minimum 75%, Missing); duodenum: 74.0741% (minimum 75%, Missing); esophagus: 64.5161% (minimum 70%, Missing); heart muscle: 57.1429% (minimum 75%, Missing); hippocampal formation: 60.6061% (minimum 75%, Missing); hypothalamus: 58.8235% (minimum 75%, Missing); kidney: 74.0741% (minimum 75%, Missing); lung: 60.6061% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 60.6061% (minimum 75%, Missing); pancreas: 54.0541% (minimum 75%, Missing); pituitary gland: 52.6316% (minimum 75%, Missing); retina: 30.7692% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 74.0741% (minimum 75%, Missing); skin: 47.6190% (minimum 65%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); thyroid gland: 45.4545% (minimum 65%, Missing)",-0.195455,-0.2,-0.522727,0,80,unavailable,6.8,2,2.4,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171847,FAM90A1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 52.6316% (minimum 75%, Missing); amygdala: 62.5000% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebellum: 47.6190% (minimum 75%, Missing); cerebral cortex: 22.7273% (minimum 75%, Missing); duodenum: 74.0741% (minimum 75%, Missing); esophagus: 64.5161% (minimum 70%, Missing); heart muscle: 57.1429% (minimum 75%, Missing); hippocampal formation: 60.6061% (minimum 75%, Missing); hypothalamus: 58.8235% (minimum 75%, Missing); kidney: 74.0741% (minimum 75%, Missing); lung: 60.6061% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 60.6061% (minimum 75%, Missing); pancreas: 54.0541% (minimum 75%, Missing); pituitary gland: 52.6316% (minimum 75%, Missing); retina: 30.7692% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 74.0741% (minimum 75%, Missing); skin: 47.6190% (minimum 65%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); thyroid gland: 45.4545% (minimum 65%, Missing)",-0.195455,-0.2,-0.522727,0,80,unavailable,6.8,2,2.4,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171847,FAM90A1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 52.6316% (minimum 75%, Missing); amygdala: 62.5000% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebellum: 47.6190% (minimum 75%, Missing); cerebral cortex: 22.7273% (minimum 75%, Missing); duodenum: 74.0741% (minimum 75%, Missing); esophagus: 64.5161% (minimum 70%, Missing); heart muscle: 57.1429% (minimum 75%, Missing); hippocampal formation: 60.6061% (minimum 75%, Missing); hypothalamus: 58.8235% (minimum 75%, Missing); kidney: 74.0741% (minimum 75%, Missing); lung: 60.6061% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 60.6061% (minimum 75%, Missing); pancreas: 54.0541% (minimum 75%, Missing); pituitary gland: 52.6316% (minimum 75%, Missing); retina: 30.7692% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 74.0741% (minimum 75%, Missing); skin: 47.6190% (minimum 65%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); thyroid gland: 45.4545% (minimum 65%, Missing)",-0.195455,-0.2,-0.522727,0,80,unavailable,6.8,2,2.4,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171847,FAM90A1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 52.6316% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.5000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 50.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 47.6190% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 22.7273% (minimum 75%, Baseline (adaptation disabled)); duodenum: 74.0741% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.5161% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 57.1429% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 60.6061% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.8235% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.0741% (minimum 75%, Baseline (adaptation disabled)); lung: 60.6061% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); midbrain: 60.6061% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.0541% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 52.6316% (minimum 75%, Baseline (adaptation disabled)); retina: 30.7692% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 74.0741% (minimum 75%, Baseline (adaptation disabled)); skin: 47.6190% (minimum 65%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 45.4545% (minimum 65%, Baseline (adaptation disabled))",-0.195455,-0.2,-0.522727,0,80,unavailable,6.8,2,2.4,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171847,FAM90A1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.5860% (minimum 99%, Missing)",0.0485486,0.0285486,-0.35414,0,1,partial,39.4,1.9,0.2,"choroid plexus: 39.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171864,PRND,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.5860% (minimum 75%, Missing)",0.348549,0.298549,-0.11414,0,1,partial,39.4,1.9,0.2,"choroid plexus: 39.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171864,PRND,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.5860% (minimum 75%, Missing)",0.348549,0.298549,-0.11414,0,1,partial,39.4,1.9,0.2,"choroid plexus: 39.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171864,PRND,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.5860% (minimum 75%, Missing)",0.348549,0.298549,-0.11414,0,1,partial,39.4,1.9,0.2,"choroid plexus: 39.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171864,PRND,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.5860% (minimum 75%, Baseline (adaptation disabled))",0.347101,0.273126,-0.11414,0,1,partial,39.4,1.9,0.2,"choroid plexus: 39.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171864,PRND,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.1860% (minimum 95%, Enhanced); amygdala: 98.7805% (minimum 99%, Missing); hippocampal formation: 98.7805% (minimum 99%, Missing); midbrain: 98.7805% (minimum 99%, Missing); smooth muscle: 88.0435% (minimum 95%, Enhanced); spinal cord: 98.7805% (minimum 99%, Missing)",0.05,0.03,-0.0695652,0,2,partial,1.1,1,0.1,,,52,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171872,KLF17,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.237805,0,2,partial,1.1,1,0.1,,,52,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171872,KLF17,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.237805,0,2,partial,1.1,1,0.1,,,52,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171872,KLF17,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.237805,0,2,partial,1.1,1,0.1,,,52,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171872,KLF17,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.337805,0.19011,0.130435,0,2,partial,1.1,1,0.1,"smooth muscle: 1.1 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171872,KLF17,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.0000% (minimum 99%, Missing); amygdala: 98.9583% (minimum 99%, Missing); basal ganglia: 97.9381% (minimum 99%, Missing); cerebellum: 87.9630% (minimum 99%, Missing); cerebral cortex: 98.9583% (minimum 99%, Missing); choroid plexus: 93.1373% (minimum 99%, Missing); duodenum: 97.9381% (minimum 99%, Missing); hippocampal formation: 97.9381% (minimum 99%, Missing); hypothalamus: 96.9388% (minimum 99%, Missing); kidney: 96.9388% (minimum 99%, Missing); liver: 92.2330% (minimum 99%, Missing); lung: 96.9388% (minimum 99%, Missing); midbrain: 97.9381% (minimum 99%, Missing); pancreas: 98.9583% (minimum 99%, Missing); pituitary gland: 96.9388% (minimum 99%, Missing); salivary gland: 96.9388% (minimum 97%, Missing); skeletal muscle: 94.0594% (minimum 99%, Missing); spinal cord: 97.9381% (minimum 99%, Missing); thyroid gland: 92.2330% (minimum 95%, Missing)",-0.0276699,-0.000612245,-0.11037,0,80,unavailable,1.3,0.3,0.8,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171931,FBXW10,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.27233,0.269388,0.12963,0,80,unavailable,1.3,0.3,0.8,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171931,FBXW10,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.27233,0.269388,0.12963,0,80,unavailable,1.3,0.3,0.8,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171931,FBXW10,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.27233,0.269388,0.12963,0,80,unavailable,1.3,0.3,0.8,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171931,FBXW10,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.27233,0.269388,0.12963,0,80,unavailable,1.3,0.3,0.8,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171931,FBXW10,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 85.7143% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); cerebellum: 85.7143% (minimum 99%, Missing); hypothalamus: 15.3846% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 12.7660% (minimum 99%, Missing); skeletal muscle: 85.7143% (minimum 99%, Missing); spinal cord: 31.5789% (minimum 99%, Missing); stomach: 75.0000% (minimum 97%, Missing)",0.05,-0.22,-0.86234,0,80,unavailable,4.1,0.2,0,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171956,FOXB1,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 75.0000% (minimum 75%, Missing); hypothalamus: 15.3846% (minimum 75%, Missing); midbrain: 12.7660% (minimum 75%, Missing); spinal cord: 31.5789% (minimum 75%, Missing)",0.35,0.05,-0.62234,0,80,unavailable,4.1,0.2,0,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171956,FOXB1,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 75.0000% (minimum 75%, Missing); hypothalamus: 15.3846% (minimum 75%, Missing); midbrain: 12.7660% (minimum 75%, Missing); spinal cord: 31.5789% (minimum 75%, Missing)",0.35,0.05,-0.62234,0,80,unavailable,4.1,0.2,0,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171956,FOXB1,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 75.0000% (minimum 75%, Missing); hypothalamus: 15.3846% (minimum 75%, Missing); midbrain: 12.7660% (minimum 75%, Missing); spinal cord: 31.5789% (minimum 75%, Missing)",0.35,0.05,-0.62234,0,80,unavailable,4.1,0.2,0,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171956,FOXB1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 75.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 15.3846% (minimum 75%, Baseline (adaptation disabled)); midbrain: 12.7660% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 31.5789% (minimum 75%, Baseline (adaptation disabled))",0.35,0.05,-0.62234,0,80,unavailable,4.1,0.2,0,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171956,FOXB1,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.8383% (minimum 95%, Missing); adrenal gland: 65.8754% (minimum 99%, Missing); amygdala: 90.9836% (minimum 99%, Missing); basal ganglia: 89.8785% (minimum 99%, Missing); bone marrow: 38.0137% (minimum 99%, Missing); cerebellum: 67.6829% (minimum 99%, Missing); cerebral cortex: 64.3478% (minimum 99%, Missing); choroid plexus: 77.8947% (minimum 99%, Missing); colon: 68.0982% (minimum 97%, Missing); duodenum: 58.2677% (minimum 99%, Missing); esophagus: 65.2941% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 90.6122% (minimum 99%, Missing); hypothalamus: 90.9836% (minimum 99%, Missing); kidney: 60.9890% (minimum 99%, Missing); liver: 51.9906% (minimum 99%, Missing); lung: 60.3261% (minimum 99%, Missing); lymph node: 51.7483% (minimum 97%, Missing); midbrain: 90.9836% (minimum 99%, Missing); pancreas: 64.7230% (minimum 99%, Missing); parathyroid gland: 52.4823% (minimum 97%, Missing); pituitary gland: 90.6122% (minimum 99%, Missing); rectum: 66.0714% (minimum 97%, Missing); retina: 36.6942% (minimum 99%, Missing); salivary gland: 64.7230% (minimum 97%, Missing); skeletal muscle: 76.5517% (minimum 99%, Missing); skin: 68.0982% (minimum 95%, Missing); small intestine: 55.7789% (minimum 99%, Missing); smooth muscle: 60.8219% (minimum 99%, Missing); spinal cord: 90.9836% (minimum 99%, Missing); spleen: 53.1100% (minimum 95%, Missing); stomach: 62.1849% (minimum 97%, Missing); thymus: 54.2787% (minimum 95%, Missing); thyroid gland: 53.7530% (minimum 95%, Missing); tongue: 64.1618% (minimum 97%, Missing); urinary bladder: 60.4905% (minimum 97%, Missing)",-0.4189,-0.452517,-0.623058,0,1,partial,38.3,20.7,19.6,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 2); spleen: 19.6 nTPM (manageable, limit 5); thyroid gland: 19.1 nTPM (manageable, limit 5); thymus: 18.7 nTPM (manageable, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 2); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 2); tongue: 12.4 nTPM (protected, limit 2); cerebral cortex: 12.3 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 2); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 2); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171988,JMJD1C,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.8383% (minimum 65%, Missing); adrenal gland: 65.8754% (minimum 75%, Missing); bone marrow: 38.0137% (minimum 75%, Missing); cerebellum: 67.6829% (minimum 75%, Missing); cerebral cortex: 64.3478% (minimum 75%, Missing); colon: 68.0982% (minimum 70%, Missing); duodenum: 58.2677% (minimum 75%, Missing); esophagus: 65.2941% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 60.9890% (minimum 75%, Missing); liver: 51.9906% (minimum 75%, Missing); lung: 60.3261% (minimum 75%, Missing); lymph node: 51.7483% (minimum 70%, Missing); pancreas: 64.7230% (minimum 75%, Missing); parathyroid gland: 52.4823% (minimum 70%, Missing); rectum: 66.0714% (minimum 70%, Missing); retina: 36.6942% (minimum 75%, Missing); salivary gland: 64.7230% (minimum 70%, Missing); small intestine: 55.7789% (minimum 75%, Missing); smooth muscle: 60.8219% (minimum 75%, Missing); spleen: 53.1100% (minimum 65%, Missing); stomach: 62.1849% (minimum 70%, Missing); thymus: 54.2787% (minimum 65%, Missing); thyroid gland: 53.7530% (minimum 65%, Missing); tongue: 64.1618% (minimum 70%, Missing); urinary bladder: 60.4905% (minimum 70%, Missing)",-0.1189,-0.182517,-0.383058,0,1,partial,38.3,20.7,19.6,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 2); spleen: 19.6 nTPM (manageable, limit 5); thyroid gland: 19.1 nTPM (manageable, limit 5); thymus: 18.7 nTPM (manageable, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 2); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 2); tongue: 12.4 nTPM (protected, limit 2); cerebral cortex: 12.3 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 2); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 2); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171988,JMJD1C,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.8383% (minimum 65%, Missing); adrenal gland: 65.8754% (minimum 75%, Missing); bone marrow: 38.0137% (minimum 75%, Missing); cerebellum: 67.6829% (minimum 75%, Missing); cerebral cortex: 64.3478% (minimum 75%, Missing); colon: 68.0982% (minimum 70%, Missing); duodenum: 58.2677% (minimum 75%, Missing); esophagus: 65.2941% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 60.9890% (minimum 75%, Missing); liver: 51.9906% (minimum 75%, Missing); lung: 60.3261% (minimum 75%, Missing); lymph node: 51.7483% (minimum 70%, Missing); pancreas: 64.7230% (minimum 75%, Missing); parathyroid gland: 52.4823% (minimum 70%, Missing); rectum: 66.0714% (minimum 70%, Missing); retina: 36.6942% (minimum 75%, Missing); salivary gland: 64.7230% (minimum 70%, Missing); small intestine: 55.7789% (minimum 75%, Missing); smooth muscle: 60.8219% (minimum 75%, Missing); spleen: 53.1100% (minimum 65%, Missing); stomach: 62.1849% (minimum 70%, Missing); thymus: 54.2787% (minimum 65%, Missing); thyroid gland: 53.7530% (minimum 65%, Missing); tongue: 64.1618% (minimum 70%, Missing); urinary bladder: 60.4905% (minimum 70%, Missing)",-0.1189,-0.182517,-0.383058,0,1,partial,38.3,20.7,19.6,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 3); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 3); spleen: 19.6 nTPM (manageable, limit 5); thyroid gland: 19.1 nTPM (manageable, limit 5); thymus: 18.7 nTPM (manageable, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 3); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 3); tongue: 12.4 nTPM (protected, limit 3); cerebral cortex: 12.3 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 3); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 3); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171988,JMJD1C,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.8383% (minimum 65%, Missing); adrenal gland: 65.8754% (minimum 75%, Missing); bone marrow: 38.0137% (minimum 75%, Missing); cerebellum: 67.6829% (minimum 75%, Missing); cerebral cortex: 64.3478% (minimum 75%, Missing); colon: 68.0982% (minimum 70%, Missing); duodenum: 58.2677% (minimum 75%, Missing); esophagus: 65.2941% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 60.9890% (minimum 75%, Missing); liver: 51.9906% (minimum 75%, Missing); lung: 60.3261% (minimum 75%, Missing); lymph node: 51.7483% (minimum 70%, Missing); pancreas: 64.7230% (minimum 75%, Missing); parathyroid gland: 52.4823% (minimum 70%, Missing); rectum: 66.0714% (minimum 70%, Missing); retina: 36.6942% (minimum 75%, Missing); salivary gland: 64.7230% (minimum 70%, Missing); small intestine: 55.7789% (minimum 75%, Missing); smooth muscle: 60.8219% (minimum 75%, Missing); spleen: 53.1100% (minimum 65%, Missing); stomach: 62.1849% (minimum 70%, Missing); thymus: 54.2787% (minimum 65%, Missing); thyroid gland: 53.7530% (minimum 65%, Missing); tongue: 64.1618% (minimum 70%, Missing); urinary bladder: 60.4905% (minimum 70%, Missing)",-0.1189,-0.182517,-0.383058,0,1,partial,38.3,20.7,19.6,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 3); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 3); spleen: 19.6 nTPM (manageable, limit 5); thyroid gland: 19.1 nTPM (manageable, limit 5); thymus: 18.7 nTPM (manageable, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 3); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 3); tongue: 12.4 nTPM (protected, limit 3); cerebral cortex: 12.3 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 3); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 3); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171988,JMJD1C,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.8383% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 65.8754% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 38.0137% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.6829% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.3478% (minimum 75%, Baseline (adaptation disabled)); colon: 68.0982% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.2677% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.2941% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.9890% (minimum 75%, Baseline (adaptation disabled)); liver: 51.9906% (minimum 75%, Baseline (adaptation disabled)); lung: 60.3261% (minimum 75%, Baseline (adaptation disabled)); lymph node: 51.7483% (minimum 70%, Baseline (adaptation disabled)); pancreas: 64.7230% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.4823% (minimum 70%, Baseline (adaptation disabled)); rectum: 66.0714% (minimum 70%, Baseline (adaptation disabled)); retina: 36.6942% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.7230% (minimum 70%, Baseline (adaptation disabled)); small intestine: 55.7789% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.8219% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.1100% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.1849% (minimum 70%, Baseline (adaptation disabled)); thymus: 54.2787% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.7530% (minimum 65%, Baseline (adaptation disabled)); tongue: 64.1618% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.4905% (minimum 70%, Baseline (adaptation disabled))",-0.1189,-0.182517,-0.383058,0,1,partial,38.3,20.7,19.6,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 3); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 3); spleen: 19.6 nTPM (manageable, limit 5); thyroid gland: 19.1 nTPM (manageable, limit 5); thymus: 18.7 nTPM (manageable, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 3); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 3); tongue: 12.4 nTPM (protected, limit 3); cerebral cortex: 12.3 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 3); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 3); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171988,JMJD1C,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.00747475,0,1,partial,0.3,0.2,0.3,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171989,LDHAL6B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247475,0,1,partial,0.3,0.2,0.3,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171989,LDHAL6B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247475,0,1,partial,0.3,0.2,0.3,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171989,LDHAL6B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247475,0,1,partial,0.3,0.2,0.3,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171989,LDHAL6B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342462,0.294962,0.242462,0,1,partial,0.3,0.2,0.3,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000171989,LDHAL6B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172073,SPMIP9,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172073,SPMIP9,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172073,SPMIP9,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172073,SPMIP9,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172073,SPMIP9,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 96.2963% (minimum 99%, Missing); pancreas: 98.7342% (minimum 99%, Missing); skin: 78.7879% (minimum 95%, Missing)",-0.162121,0.0173418,-0.027037,0,80,unavailable,0.3,0.1,2.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172139,SLC9C1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.137879,0.287342,0.212963,0,80,unavailable,0.3,0.1,2.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172139,SLC9C1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.137879,0.287342,0.212963,0,80,unavailable,0.3,0.1,2.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172139,SLC9C1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.137879,0.287342,0.212963,0,80,unavailable,0.3,0.1,2.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172139,SLC9C1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.137879,0.287342,0.212963,0,80,unavailable,0.3,0.1,2.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172139,SLC9C1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.6327% (minimum 90%, Approved); adrenal gland: 90.9091% (minimum 99%, Missing); amygdala: 86.9565% (minimum 99%, Missing); basal ganglia: 80.0000% (minimum 99%, Missing); bone marrow: 78.4314% (minimum 99%, Missing); cerebellum: 88.8889% (minimum 99%, Missing); cerebral cortex: 78.4314% (minimum 99%, Missing); choroid plexus: 97.5610% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); duodenum: 86.9565% (minimum 99%, Missing); esophagus: 80.0000% (minimum 97%, Missing); heart muscle: 88.8889% (minimum 99%, Missing); hippocampal formation: 86.9565% (minimum 99%, Missing); hypothalamus: 86.9565% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 90.9091% (minimum 99%, Missing); lung: 86.9565% (minimum 99%, Missing); lymph node: 59.7015% (minimum 97%, Missing); midbrain: 90.9091% (minimum 99%, Missing); pancreas: 93.0233% (minimum 99%, Missing); parathyroid gland: 90.9091% (minimum 97%, Missing); pituitary gland: 93.0233% (minimum 99%, Missing); rectum: 76.9231% (minimum 97%, Missing); retina: 88.8889% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 90.9091% (minimum 99%, Missing); skin: 75.4717% (minimum 95%, Missing); small intestine: 85.1064% (minimum 99%, Missing); smooth muscle: 78.4314% (minimum 98%, Approved); spinal cord: 90.9091% (minimum 99%, Missing); spleen: 81.6327% (minimum 90%, Approved); stomach: 85.1064% (minimum 97%, Missing); thymus: 53.3333% (minimum 95%, Missing); thyroid gland: 78.4314% (minimum 95%, Missing); tongue: 90.9091% (minimum 97%, Missing); urinary bladder: 74.0741% (minimum 97%, Missing)",-0.416667,-0.372985,-0.205686,0,3,partial,1.1,2.7,3.5,"lymph node: 2.7 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172244,C5orf34,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 59.7015% (minimum 70%, Missing); thymus: 53.3333% (minimum 65%, Missing)",-0.116667,-0.102985,0.0343137,0,3,partial,1.1,2.7,3.5,"lymph node: 2.7 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172244,C5orf34,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 59.7015% (minimum 70%, Missing); thymus: 53.3333% (minimum 65%, Missing)",-0.116667,-0.102985,0.0343137,0,3,partial,1.1,2.7,3.5,"bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172244,C5orf34,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 59.7015% (minimum 70%, Missing); thymus: 53.3333% (minimum 65%, Missing)",-0.116667,-0.102985,0.0343137,0,3,partial,1.1,2.7,3.5,"bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172244,C5orf34,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 59.7015% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.3333% (minimum 65%, Baseline (adaptation disabled))",-0.116667,-0.102985,0.0343137,0,3,partial,1.1,2.7,3.5,"bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172244,C5orf34,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172288,CDY1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172288,CDY1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172288,CDY1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172288,CDY1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172288,CDY1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 99%, Missing); bone marrow: 33.3333% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); pancreas: 66.6667% (minimum 99%, Missing); retina: 33.3333% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 40.0000% (minimum 95%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing)",-0.55,-0.303333,-0.656667,0,80,unavailable,0.4,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172320,OR5A1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 33.3333% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); skin: 40.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.25,-0.0333333,-0.416667,0,80,unavailable,0.4,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172320,OR5A1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 33.3333% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); skin: 40.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.25,-0.0333333,-0.416667,0,80,unavailable,0.4,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172320,OR5A1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 33.3333% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); skin: 40.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.25,-0.0333333,-0.416667,0,80,unavailable,0.4,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172320,OR5A1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 33.3333% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 33.3333% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); skin: 40.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 70%, Baseline (adaptation disabled))",-0.25,-0.0333333,-0.416667,0,80,unavailable,0.4,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172320,OR5A1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172352,CDY1B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172352,CDY1B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172352,CDY1B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172352,CDY1B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172352,CDY1B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.2687% (minimum 99%, Missing); basal ganglia: 93.0288% (minimum 99%, Missing); cerebellum: 94.2753% (minimum 95%, Enhanced); choroid plexus: 79.5478% (minimum 99%, Missing); hippocampal formation: 94.8529% (minimum 99%, Missing); hypothalamus: 93.8182% (minimum 99%, Missing); midbrain: 97.4811% (minimum 99%, Missing); pancreas: 98.5987% (minimum 99%, Missing); pituitary gland: 96.0298% (minimum 99%, Missing); retina: 95.7921% (minimum 99%, Missing); spinal cord: 97.3585% (minimum 99%, Missing)",0.0435815,0.0248586,-0.194522,0,6,partial,19.9,2.4,3.7,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172361,CFAP53,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343582,0.294859,0.0454779,0,6,partial,19.9,2.4,3.7,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172361,CFAP53,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343582,0.294859,0.0454779,0,6,partial,19.9,2.4,3.7,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172361,CFAP53,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343582,0.294859,0.0454779,0,6,partial,19.9,2.4,3.7,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172361,CFAP53,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.304377,0.269925,0.0454779,0,6,partial,19.9,2.4,3.7,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172361,CFAP53,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172362,OR5B12,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172362,OR5B12,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172362,OR5B12,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172362,OR5B12,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172362,OR5B12,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 33.3333% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); retina: 33.3333% (minimum 99%, Missing)",0.05,-0.47,-0.656667,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172365,OR5B2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); retina: 33.3333% (minimum 75%, Missing)",0.35,-0.2,-0.416667,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172365,OR5B2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); retina: 33.3333% (minimum 75%, Missing)",0.35,-0.2,-0.416667,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172365,OR5B2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); retina: 33.3333% (minimum 75%, Missing)",0.35,-0.2,-0.416667,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172365,OR5B2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 33.3333% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 33.3333% (minimum 75%, Baseline (adaptation disabled))",0.35,-0.2,-0.416667,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172365,OR5B2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 93.5484% (minimum 95%, Uncertain); retina: 96.6667% (minimum 99%, Missing)",-0.0145161,0.0130508,-0.0233333,0,2,partial,0.2,0.1,0.4,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172421,EFCAB3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.285484,0.283051,0.216667,0,2,partial,0.2,0.1,0.4,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172421,EFCAB3,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.285484,0.283051,0.216667,0,2,partial,0.2,0.1,0.4,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172421,EFCAB3,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.285484,0.283051,0.216667,0,2,partial,0.2,0.1,0.4,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172421,EFCAB3,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.285484,0.283051,0.216667,0,2,partial,0.2,0.1,0.4,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172421,EFCAB3,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.3580% (minimum 90%, Approved); adrenal gland: 76.1583% (minimum 99%, Missing); amygdala: 80.0095% (minimum 99%, Missing); basal ganglia: 81.7874% (minimum 99%, Missing); bone marrow: 94.5282% (minimum 99%, Missing); cerebellum: 75.0776% (minimum 98%, Approved); cerebral cortex: 75.4456% (minimum 99%, Missing); choroid plexus: 83.8949% (minimum 99%, Missing); colon: 74.1568% (minimum 97%, Missing); duodenum: 92.0109% (minimum 99%, Missing); esophagus: 82.2244% (minimum 97%, Missing); heart muscle: 84.4810% (minimum 98%, Approved); hippocampal formation: 79.6706% (minimum 99%, Missing); hypothalamus: 76.0557% (minimum 99%, Missing); kidney: 87.4032% (minimum 99%, Missing); liver: 90.1491% (minimum 98%, Approved); lung: 85.1181% (minimum 99%, Missing); lymph node: 92.5137% (minimum 97%, Missing); midbrain: 84.3548% (minimum 99%, Missing); pancreas: 89.5767% (minimum 98%, Approved); parathyroid gland: 84.6077% (minimum 95%, Approved); pituitary gland: 83.6876% (minimum 99%, Missing); rectum: 91.2668% (minimum 97%, Missing); retina: 92.2113% (minimum 99%, Missing); salivary gland: 91.5630% (minimum 97%, Missing); skeletal muscle: 76.0899% (minimum 98%, Approved); skin: 90.9726% (minimum 95%, Missing); small intestine: 85.6781% (minimum 99%, Missing); smooth muscle: 64.9405% (minimum 99%, Missing); spinal cord: 85.7649% (minimum 99%, Missing); spleen: 86.8651% (minimum 90%, Approved); stomach: 81.2770% (minimum 95%, Approved); thymus: 93.4327% (minimum 95%, Missing); thyroid gland: 84.5232% (minimum 95%, Missing); tongue: 83.9782% (minimum 97%, Missing); urinary bladder: 64.1288% (minimum 97%, Missing)",-0.104768,-0.328712,-0.340595,0,7,partial,91.4,94.7,33.8,"urinary bladder: 94.7 nTPM (protected, limit 2); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 2); cerebellum: 56.2 nTPM (vital, limit 2); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 2); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 4); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 2); adipose tissue: 33.8 nTPM (manageable, limit 10); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 2); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 2); thyroid gland: 31 nTPM (manageable, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 4); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); spleen: 25.6 nTPM (manageable, limit 10); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 2); liver: 18.5 nTPM (vital, limit 2); skin: 16.8 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 2); salivary gland: 15.6 nTPM (protected, limit 2); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 2); thymus: 11.9 nTPM (manageable, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172465,TCEAL1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"smooth muscle: 64.9405% (minimum 75%, Missing); urinary bladder: 64.1288% (minimum 70%, Missing)",0.195232,-0.0587121,-0.100595,0,7,partial,91.4,94.7,33.8,"urinary bladder: 94.7 nTPM (protected, limit 2); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 2); cerebellum: 56.2 nTPM (vital, limit 2); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 2); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 4); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 2); adipose tissue: 33.8 nTPM (manageable, limit 10); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 2); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 2); thyroid gland: 31 nTPM (manageable, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 4); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); spleen: 25.6 nTPM (manageable, limit 10); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 2); liver: 18.5 nTPM (vital, limit 2); skin: 16.8 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 2); salivary gland: 15.6 nTPM (protected, limit 2); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 2); thymus: 11.9 nTPM (manageable, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172465,TCEAL1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"smooth muscle: 64.9405% (minimum 75%, Missing); urinary bladder: 64.1288% (minimum 70%, Missing)",0.195232,-0.0587121,-0.100595,0,7,partial,91.4,94.7,33.8,"urinary bladder: 94.7 nTPM (protected, limit 3); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 3); cerebellum: 56.2 nTPM (vital, limit 2); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 2); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 4); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 3); adipose tissue: 33.8 nTPM (manageable, limit 10); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 3); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 2); thyroid gland: 31 nTPM (manageable, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 4); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); spleen: 25.6 nTPM (manageable, limit 10); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 2); liver: 18.5 nTPM (vital, limit 2); skin: 16.8 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 3); salivary gland: 15.6 nTPM (protected, limit 3); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 3); thymus: 11.9 nTPM (manageable, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172465,TCEAL1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"smooth muscle: 64.9405% (minimum 75%, Missing); urinary bladder: 64.1288% (minimum 70%, Missing)",0.195232,-0.0587121,-0.100595,0,7,partial,91.4,94.7,33.8,"urinary bladder: 94.7 nTPM (protected, limit 3); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 3); cerebellum: 56.2 nTPM (vital, limit 2); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 2); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 4); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 3); adipose tissue: 33.8 nTPM (manageable, limit 10); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 3); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 2); thyroid gland: 31 nTPM (manageable, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 4); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); spleen: 25.6 nTPM (manageable, limit 10); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 2); liver: 18.5 nTPM (vital, limit 2); skin: 16.8 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 3); salivary gland: 15.6 nTPM (protected, limit 3); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 3); thymus: 11.9 nTPM (manageable, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172465,TCEAL1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"smooth muscle: 64.9405% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 64.1288% (minimum 70%, Baseline (adaptation disabled))",0.18358,-0.0587121,-0.100595,0,7,partial,91.4,94.7,33.8,"urinary bladder: 94.7 nTPM (protected, limit 3); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 3); cerebellum: 56.2 nTPM (vital, limit 1); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 1); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 3); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 3); adipose tissue: 33.8 nTPM (manageable, limit 5); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 3); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 1); thyroid gland: 31 nTPM (manageable, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 3); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); spleen: 25.6 nTPM (manageable, limit 5); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 3); salivary gland: 15.6 nTPM (protected, limit 3); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 3); thymus: 11.9 nTPM (manageable, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172465,TCEAL1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 97.1698% (minimum 99%, Missing); basal ganglia: 97.1698% (minimum 99%, Missing); cerebellum: 97.1698% (minimum 99%, Missing); cerebral cortex: 96.2617% (minimum 99%, Missing); hippocampal formation: 96.2617% (minimum 99%, Missing); hypothalamus: 93.6364% (minimum 99%, Missing); kidney: 98.0952% (minimum 99%, Missing); midbrain: 98.0952% (minimum 99%, Missing); retina: 98.0952% (minimum 99%, Missing)",0.05,0.0203846,-0.0536364,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172468,HSFY1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.290385,0.186364,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172468,HSFY1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.290385,0.186364,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172468,HSFY1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.290385,0.186364,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172468,HSFY1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.290385,0.186364,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000172468,HSFY1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 99%, Missing); bone marrow: 25.0000% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); lymph node: 66.6667% (minimum 97%, Missing); pancreas: 66.6667% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 40.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 25.0000% (minimum 99%, Missing); skin: 40.0000% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing)",-0.55,-0.303333,-0.74,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172519,OR10H5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 40.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 25.0000% (minimum 75%, Missing); skin: 40.0000% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.25,-0.0333333,-0.5,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172519,OR10H5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 40.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 25.0000% (minimum 75%, Missing); skin: 40.0000% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.25,-0.0333333,-0.5,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172519,OR10H5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 40.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 25.0000% (minimum 75%, Missing); skin: 40.0000% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.25,-0.0333333,-0.5,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172519,OR10H5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 25.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 40.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 25.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 40.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 70%, Baseline (adaptation disabled))",-0.25,-0.0333333,-0.5,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172519,OR10H5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172538,FAM170B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172538,FAM170B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172538,FAM170B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172538,FAM170B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172538,FAM170B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.8987% (minimum 95%, Enhanced); amygdala: 94.2857% (minimum 99%, Missing); basal ganglia: 95.0262% (minimum 99%, Missing); bone marrow: 94.2857% (minimum 95%, Enhanced); cerebellum: 84.6154% (minimum 95%, Enhanced); choroid plexus: 97.5806% (minimum 99%, Missing); colon: 94.5312% (minimum 97%, Missing); duodenum: 94.7781% (minimum 99%, Missing); heart muscle: 93.7984% (minimum 95%, Enhanced); hippocampal formation: 94.0415% (minimum 99%, Missing); hypothalamus: 91.4358% (minimum 99%, Missing); kidney: 94.7781% (minimum 99%, Missing); liver: 90.5237% (minimum 95%, Enhanced); lung: 94.2857% (minimum 95%, Enhanced); lymph node: 88.3212% (minimum 97%, Missing); midbrain: 92.6020% (minimum 99%, Missing); pancreas: 93.7984% (minimum 95%, Enhanced); pituitary gland: 92.6020% (minimum 99%, Missing); retina: 94.5312% (minimum 99%, Missing); skeletal muscle: 94.2857% (minimum 95%, Enhanced); small intestine: 94.7781% (minimum 99%, Missing); spinal cord: 89.8515% (minimum 99%, Missing); stomach: 95.2756% (minimum 97%, Missing); thymus: 92.1320% (minimum 95%, Missing); tongue: 96.0317% (minimum 97%, Missing)",-0.0286802,-0.0867883,-0.103846,0,5,partial,6.6,4.8,3.3,"cerebellum: 6.6 nTPM (vital, limit 6); lymph node: 4.8 nTPM (protected, limit 2); spinal cord: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); retina: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172671,ZFAND4,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.27132,0.183212,0.148515,0,5,partial,6.6,4.8,3.3,"cerebellum: 6.6 nTPM (vital, limit 6); lymph node: 4.8 nTPM (protected, limit 2); spinal cord: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); retina: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172671,ZFAND4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.27132,0.183212,0.148515,0,5,partial,6.6,4.8,3.3,"cerebellum: 6.6 nTPM (vital, limit 6); lymph node: 4.8 nTPM (protected, limit 3); spinal cord: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172671,ZFAND4,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.27132,0.183212,0.148515,0,5,partial,6.6,4.8,3.3,"cerebellum: 6.6 nTPM (vital, limit 6); lymph node: 4.8 nTPM (protected, limit 3); spinal cord: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172671,ZFAND4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.266667,0.183212,0.0961538,0,5,partial,6.6,4.8,3.3,"cerebellum: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 3); spinal cord: 4.1 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172671,ZFAND4,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing)",0.05,0.03,-0.115,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172680,MOS,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.125,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172680,MOS,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.125,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172680,MOS,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.125,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172680,MOS,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.125,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172680,MOS,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 96.6805% (minimum 99%, Missing)",0.0331224,0.0214894,-0.023195,0,80,unavailable,0.8,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172717,GARIN2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333122,0.291489,0.216805,0,80,unavailable,0.8,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172717,GARIN2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333122,0.291489,0.216805,0,80,unavailable,0.8,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172717,GARIN2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333122,0.291489,0.216805,0,80,unavailable,0.8,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172717,GARIN2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333122,0.291489,0.216805,0,80,unavailable,0.8,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172717,GARIN2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 89.2857% (minimum 95%, Enhanced); amygdala: 34.2466% (minimum 99%, Missing); basal ganglia: 28.0899% (minimum 99%, Missing); cerebellum: 17.8571% (minimum 99%, Missing); cerebral cortex: 31.2500% (minimum 99%, Missing); choroid plexus: 65.7895% (minimum 99%, Missing); colon: 89.2857% (minimum 97%, Missing); heart muscle: 86.2069% (minimum 95%, Enhanced); hippocampal formation: 34.2466% (minimum 99%, Missing); hypothalamus: 34.2466% (minimum 99%, Missing); kidney: 86.2069% (minimum 99%, Missing); lung: 92.5926% (minimum 99%, Missing); midbrain: 39.6825% (minimum 99%, Missing); pituitary gland: 46.2963% (minimum 99%, Missing); retina: 37.3134% (minimum 99%, Missing); skeletal muscle: 96.1538% (minimum 99%, Missing); small intestine: 92.5926% (minimum 95%, Enhanced); smooth muscle: 64.1026% (minimum 95%, Enhanced); spinal cord: 40.3226% (minimum 99%, Missing); tongue: 96.1538% (minimum 97%, Missing)",0.0115385,-0.0771429,-0.811429,0,5,partial,11.5,0.3,0.4,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172733,PURG,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 34.2466% (minimum 75%, Missing); basal ganglia: 28.0899% (minimum 75%, Missing); cerebellum: 17.8571% (minimum 75%, Missing); cerebral cortex: 31.2500% (minimum 75%, Missing); choroid plexus: 65.7895% (minimum 75%, Missing); hippocampal formation: 34.2466% (minimum 75%, Missing); hypothalamus: 34.2466% (minimum 75%, Missing); midbrain: 39.6825% (minimum 75%, Missing); pituitary gland: 46.2963% (minimum 75%, Missing); retina: 37.3134% (minimum 75%, Missing); spinal cord: 40.3226% (minimum 75%, Missing)",0.311538,0.192857,-0.571429,0,5,partial,11.5,0.3,0.4,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172733,PURG,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 34.2466% (minimum 75%, Missing); basal ganglia: 28.0899% (minimum 75%, Missing); cerebellum: 17.8571% (minimum 75%, Missing); cerebral cortex: 31.2500% (minimum 75%, Missing); choroid plexus: 65.7895% (minimum 75%, Missing); hippocampal formation: 34.2466% (minimum 75%, Missing); hypothalamus: 34.2466% (minimum 75%, Missing); midbrain: 39.6825% (minimum 75%, Missing); pituitary gland: 46.2963% (minimum 75%, Missing); retina: 37.3134% (minimum 75%, Missing); spinal cord: 40.3226% (minimum 75%, Missing)",0.311538,0.192857,-0.571429,0,5,partial,11.5,0.3,0.4,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172733,PURG,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 34.2466% (minimum 75%, Missing); basal ganglia: 28.0899% (minimum 75%, Missing); cerebellum: 17.8571% (minimum 75%, Missing); cerebral cortex: 31.2500% (minimum 75%, Missing); choroid plexus: 65.7895% (minimum 75%, Missing); hippocampal formation: 34.2466% (minimum 75%, Missing); hypothalamus: 34.2466% (minimum 75%, Missing); midbrain: 39.6825% (minimum 75%, Missing); pituitary gland: 46.2963% (minimum 75%, Missing); retina: 37.3134% (minimum 75%, Missing); spinal cord: 40.3226% (minimum 75%, Missing)",0.311538,0.192857,-0.571429,0,5,partial,11.5,0.3,0.4,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172733,PURG,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 34.2466% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 28.0899% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 17.8571% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 31.2500% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 65.7895% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 34.2466% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 34.2466% (minimum 75%, Baseline (adaptation disabled)); midbrain: 39.6825% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 46.2963% (minimum 75%, Baseline (adaptation disabled)); retina: 37.3134% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.1026% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 40.3226% (minimum 75%, Baseline (adaptation disabled))",0.212069,0.192857,-0.571429,0,5,partial,11.5,0.3,0.4,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172733,PURG,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.5484% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); amygdala: 98.8636% (minimum 99%, Missing); basal ganglia: 98.8636% (minimum 99%, Missing); bone marrow: 76.3158% (minimum 99%, Missing); cerebral cortex: 94.5652% (minimum 99%, Missing); choroid plexus: 91.5789% (minimum 99%, Missing); duodenum: 88.7755% (minimum 99%, Missing); esophagus: 85.2941% (minimum 97%, Missing); heart muscle: 96.6667% (minimum 99%, Missing); hippocampal formation: 98.8636% (minimum 99%, Missing); hypothalamus: 98.8636% (minimum 99%, Missing); kidney: 93.5484% (minimum 99%, Missing); liver: 90.6250% (minimum 99%, Missing); lung: 92.5532% (minimum 99%, Missing); lymph node: 96.6667% (minimum 97%, Missing); midbrain: 98.8636% (minimum 99%, Missing); pancreas: 76.9912% (minimum 99%, Missing); parathyroid gland: 87.8788% (minimum 97%, Missing); pituitary gland: 98.8636% (minimum 99%, Missing); rectum: 96.6667% (minimum 97%, Missing); retina: 92.5532% (minimum 99%, Missing); salivary gland: 88.7755% (minimum 97%, Missing); skeletal muscle: 98.8636% (minimum 99%, Missing); skin: 90.6250% (minimum 95%, Missing); small intestine: 95.6044% (minimum 99%, Missing); smooth muscle: 95.6044% (minimum 99%, Missing); spinal cord: 98.8636% (minimum 99%, Missing); thymus: 92.5532% (minimum 95%, Missing); thyroid gland: 92.5532% (minimum 95%, Missing); urinary bladder: 80.5556% (minimum 97%, Missing)",-0.04375,-0.164444,-0.24,0,80,unavailable,2.9,2.1,0.9,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172738,TMEM217,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.25625,0.105556,0,0,80,unavailable,2.9,2.1,0.9,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172738,TMEM217,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.25625,0.105556,0,0,80,unavailable,2.9,2.1,0.9,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172738,TMEM217,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.25625,0.105556,0,0,80,unavailable,2.9,2.1,0.9,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172738,TMEM217,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.25625,0.105556,0,0,80,unavailable,2.9,2.1,0.9,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172738,TMEM217,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9381% (minimum 99%, Missing); amygdala: 93.5961% (minimum 99%, Missing); basal ganglia: 87.1560% (minimum 99%, Missing); bone marrow: 95.9596% (minimum 99%, Missing); cerebellum: 94.0594% (minimum 99%, Missing); cerebral cortex: 96.4467% (minimum 99%, Missing); choroid plexus: 64.4068% (minimum 99%, Missing); heart muscle: 98.4456% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 86.3636% (minimum 99%, Missing); kidney: 95.9596% (minimum 99%, Missing); liver: 94.0594% (minimum 99%, Missing); lung: 92.2330% (minimum 99%, Missing); midbrain: 97.9381% (minimum 99%, Missing); pancreas: 97.4359% (minimum 99%, Missing); parathyroid gland: 92.2330% (minimum 97%, Missing); pituitary gland: 84.4444% (minimum 99%, Missing); retina: 92.6829% (minimum 99%, Missing); small intestine: 98.4456% (minimum 99%, Missing); spinal cord: 97.4359% (minimum 99%, Missing); stomach: 96.4467% (minimum 97%, Missing); thyroid gland: 94.0594% (minimum 95%, Missing)",-0.00940594,-0.0476699,-0.345932,0,80,unavailable,10.5,1.6,1.2,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172771,EFCAB12,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 64.4068% (minimum 75%, Missing)",0.290594,0.22233,-0.105932,0,80,unavailable,10.5,1.6,1.2,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172771,EFCAB12,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 64.4068% (minimum 75%, Missing)",0.290594,0.22233,-0.105932,0,80,unavailable,10.5,1.6,1.2,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172771,EFCAB12,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 64.4068% (minimum 75%, Missing)",0.290594,0.22233,-0.105932,0,80,unavailable,10.5,1.6,1.2,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172771,EFCAB12,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 64.4068% (minimum 75%, Baseline (adaptation disabled))",0.290594,0.22233,-0.105932,0,80,unavailable,10.5,1.6,1.2,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172771,EFCAB12,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.4554% (minimum 90%, Approved); adrenal gland: 39.1459% (minimum 99%, Missing); amygdala: 63.0372% (minimum 99%, Missing); basal ganglia: 58.8235% (minimum 99%, Missing); bone marrow: 63.0372% (minimum 99%, Missing); cerebellum: 60.4396% (minimum 99%, Missing); cerebral cortex: 62.6781% (minimum 99%, Missing); choroid plexus: 41.1985% (minimum 99%, Missing); colon: 57.2917% (minimum 97%, Missing); duodenum: 62.8571% (minimum 99%, Missing); esophagus: 45.7380% (minimum 97%, Missing); heart muscle: 52.3810% (minimum 99%, Missing); hippocampal formation: 66.2651% (minimum 99%, Missing); hypothalamus: 58.5106% (minimum 99%, Missing); kidney: 36.0656% (minimum 99%, Missing); liver: 45.0820% (minimum 99%, Missing); lung: 57.8947% (minimum 99%, Missing); lymph node: 62.1469% (minimum 97%, Missing); midbrain: 62.1469% (minimum 99%, Missing); pancreas: 42.9688% (minimum 99%, Missing); parathyroid gland: 36.9748% (minimum 97%, Missing); pituitary gland: 53.7897% (minimum 99%, Missing); rectum: 58.9812% (minimum 97%, Missing); retina: 44.9898% (minimum 99%, Missing); salivary gland: 48.4581% (minimum 97%, Missing); skeletal muscle: 51.0441% (minimum 99%, Missing); skin: 50.4587% (minimum 95%, Missing); small intestine: 61.6246% (minimum 99%, Missing); smooth muscle: 65.0888% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 57.1429% (minimum 95%, Missing); stomach: 54.1872% (minimum 97%, Missing); thymus: 62.3229% (minimum 95%, Missing); thyroid gland: 46.7091% (minimum 95%, Missing); tongue: 55.5556% (minimum 97%, Missing); urinary bladder: 48.2456% (minimum 97%, Missing)",-0.482909,-0.600252,-0.629344,0,4,partial,39,37.5,25.1,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 2); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 2); thyroid gland: 25.1 nTPM (manageable, limit 5); urinary bladder: 23.6 nTPM (protected, limit 2); salivary gland: 23.4 nTPM (protected, limit 2); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 2); adipose tissue: 18.4 nTPM (manageable, limit 10); tongue: 17.6 nTPM (protected, limit 2); spleen: 16.5 nTPM (manageable, limit 5); colon: 16.4 nTPM (protected, limit 2); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 2); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 2); midbrain: 13.4 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172785,ZNG1A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.4554% (minimum 60%, Approved); adrenal gland: 39.1459% (minimum 75%, Missing); amygdala: 63.0372% (minimum 75%, Missing); basal ganglia: 58.8235% (minimum 75%, Missing); bone marrow: 63.0372% (minimum 75%, Missing); cerebellum: 60.4396% (minimum 75%, Missing); cerebral cortex: 62.6781% (minimum 75%, Missing); choroid plexus: 41.1985% (minimum 75%, Missing); colon: 57.2917% (minimum 70%, Missing); duodenum: 62.8571% (minimum 75%, Missing); esophagus: 45.7380% (minimum 70%, Missing); heart muscle: 52.3810% (minimum 75%, Missing); hippocampal formation: 66.2651% (minimum 75%, Missing); hypothalamus: 58.5106% (minimum 75%, Missing); kidney: 36.0656% (minimum 75%, Missing); liver: 45.0820% (minimum 75%, Missing); lung: 57.8947% (minimum 75%, Missing); lymph node: 62.1469% (minimum 70%, Missing); midbrain: 62.1469% (minimum 75%, Missing); pancreas: 42.9688% (minimum 75%, Missing); parathyroid gland: 36.9748% (minimum 70%, Missing); pituitary gland: 53.7897% (minimum 75%, Missing); rectum: 58.9812% (minimum 70%, Missing); retina: 44.9898% (minimum 75%, Missing); salivary gland: 48.4581% (minimum 70%, Missing); skeletal muscle: 51.0441% (minimum 75%, Missing); skin: 50.4587% (minimum 65%, Missing); small intestine: 61.6246% (minimum 75%, Missing); smooth muscle: 65.0888% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 54.1872% (minimum 70%, Missing); thymus: 62.3229% (minimum 65%, Missing); thyroid gland: 46.7091% (minimum 65%, Missing); tongue: 55.5556% (minimum 70%, Missing); urinary bladder: 48.2456% (minimum 70%, Missing)",-0.182909,-0.330252,-0.389344,0,4,partial,39,37.5,25.1,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 2); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 2); thyroid gland: 25.1 nTPM (manageable, limit 5); urinary bladder: 23.6 nTPM (protected, limit 2); salivary gland: 23.4 nTPM (protected, limit 2); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 2); adipose tissue: 18.4 nTPM (manageable, limit 10); tongue: 17.6 nTPM (protected, limit 2); spleen: 16.5 nTPM (manageable, limit 5); colon: 16.4 nTPM (protected, limit 2); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 2); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 2); midbrain: 13.4 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172785,ZNG1A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.4554% (minimum 60%, Approved); adrenal gland: 39.1459% (minimum 75%, Missing); amygdala: 63.0372% (minimum 75%, Missing); basal ganglia: 58.8235% (minimum 75%, Missing); bone marrow: 63.0372% (minimum 75%, Missing); cerebellum: 60.4396% (minimum 75%, Missing); cerebral cortex: 62.6781% (minimum 75%, Missing); choroid plexus: 41.1985% (minimum 75%, Missing); colon: 57.2917% (minimum 70%, Missing); duodenum: 62.8571% (minimum 75%, Missing); esophagus: 45.7380% (minimum 70%, Missing); heart muscle: 52.3810% (minimum 75%, Missing); hippocampal formation: 66.2651% (minimum 75%, Missing); hypothalamus: 58.5106% (minimum 75%, Missing); kidney: 36.0656% (minimum 75%, Missing); liver: 45.0820% (minimum 75%, Missing); lung: 57.8947% (minimum 75%, Missing); lymph node: 62.1469% (minimum 70%, Missing); midbrain: 62.1469% (minimum 75%, Missing); pancreas: 42.9688% (minimum 75%, Missing); parathyroid gland: 36.9748% (minimum 70%, Missing); pituitary gland: 53.7897% (minimum 75%, Missing); rectum: 58.9812% (minimum 70%, Missing); retina: 44.9898% (minimum 75%, Missing); salivary gland: 48.4581% (minimum 70%, Missing); skeletal muscle: 51.0441% (minimum 75%, Missing); skin: 50.4587% (minimum 65%, Missing); small intestine: 61.6246% (minimum 75%, Missing); smooth muscle: 65.0888% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 54.1872% (minimum 70%, Missing); thymus: 62.3229% (minimum 65%, Missing); thyroid gland: 46.7091% (minimum 65%, Missing); tongue: 55.5556% (minimum 70%, Missing); urinary bladder: 48.2456% (minimum 70%, Missing)",-0.182909,-0.330252,-0.389344,0,4,partial,39,37.5,25.1,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 3); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 3); thyroid gland: 25.1 nTPM (manageable, limit 5); urinary bladder: 23.6 nTPM (protected, limit 3); salivary gland: 23.4 nTPM (protected, limit 3); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 3); adipose tissue: 18.4 nTPM (manageable, limit 10); tongue: 17.6 nTPM (protected, limit 3); spleen: 16.5 nTPM (manageable, limit 5); colon: 16.4 nTPM (protected, limit 3); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 3); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 3); midbrain: 13.4 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172785,ZNG1A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.4554% (minimum 60%, Approved); adrenal gland: 39.1459% (minimum 75%, Missing); amygdala: 63.0372% (minimum 75%, Missing); basal ganglia: 58.8235% (minimum 75%, Missing); bone marrow: 63.0372% (minimum 75%, Missing); cerebellum: 60.4396% (minimum 75%, Missing); cerebral cortex: 62.6781% (minimum 75%, Missing); choroid plexus: 41.1985% (minimum 75%, Missing); colon: 57.2917% (minimum 70%, Missing); duodenum: 62.8571% (minimum 75%, Missing); esophagus: 45.7380% (minimum 70%, Missing); heart muscle: 52.3810% (minimum 75%, Missing); hippocampal formation: 66.2651% (minimum 75%, Missing); hypothalamus: 58.5106% (minimum 75%, Missing); kidney: 36.0656% (minimum 75%, Missing); liver: 45.0820% (minimum 75%, Missing); lung: 57.8947% (minimum 75%, Missing); lymph node: 62.1469% (minimum 70%, Missing); midbrain: 62.1469% (minimum 75%, Missing); pancreas: 42.9688% (minimum 75%, Missing); parathyroid gland: 36.9748% (minimum 70%, Missing); pituitary gland: 53.7897% (minimum 75%, Missing); rectum: 58.9812% (minimum 70%, Missing); retina: 44.9898% (minimum 75%, Missing); salivary gland: 48.4581% (minimum 70%, Missing); skeletal muscle: 51.0441% (minimum 75%, Missing); skin: 50.4587% (minimum 65%, Missing); small intestine: 61.6246% (minimum 75%, Missing); smooth muscle: 65.0888% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 54.1872% (minimum 70%, Missing); thymus: 62.3229% (minimum 65%, Missing); thyroid gland: 46.7091% (minimum 65%, Missing); tongue: 55.5556% (minimum 70%, Missing); urinary bladder: 48.2456% (minimum 70%, Missing)",-0.182909,-0.330252,-0.389344,0,4,partial,39,37.5,25.1,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 3); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 3); thyroid gland: 25.1 nTPM (manageable, limit 5); urinary bladder: 23.6 nTPM (protected, limit 3); salivary gland: 23.4 nTPM (protected, limit 3); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 3); adipose tissue: 18.4 nTPM (manageable, limit 10); tongue: 17.6 nTPM (protected, limit 3); spleen: 16.5 nTPM (manageable, limit 5); colon: 16.4 nTPM (protected, limit 3); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 3); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 3); midbrain: 13.4 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172785,ZNG1A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.4554% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 39.1459% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.0372% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.8235% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 63.0372% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.4396% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.6781% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 41.1985% (minimum 75%, Baseline (adaptation disabled)); colon: 57.2917% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.8571% (minimum 75%, Baseline (adaptation disabled)); esophagus: 45.7380% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.3810% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 66.2651% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.5106% (minimum 75%, Baseline (adaptation disabled)); kidney: 36.0656% (minimum 75%, Baseline (adaptation disabled)); liver: 45.0820% (minimum 75%, Baseline (adaptation disabled)); lung: 57.8947% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.1469% (minimum 70%, Baseline (adaptation disabled)); midbrain: 62.1469% (minimum 75%, Baseline (adaptation disabled)); pancreas: 42.9688% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 36.9748% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 53.7897% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.9812% (minimum 70%, Baseline (adaptation disabled)); retina: 44.9898% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 48.4581% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 51.0441% (minimum 75%, Baseline (adaptation disabled)); skin: 50.4587% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.6246% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.0888% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.1429% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.1872% (minimum 70%, Baseline (adaptation disabled)); thymus: 62.3229% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 46.7091% (minimum 65%, Baseline (adaptation disabled)); tongue: 55.5556% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 48.2456% (minimum 70%, Baseline (adaptation disabled))",-0.182909,-0.330252,-0.389344,0,4,partial,39,37.5,25.1,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 3); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 3); thyroid gland: 25.1 nTPM (manageable, limit 5); urinary bladder: 23.6 nTPM (protected, limit 3); salivary gland: 23.4 nTPM (protected, limit 3); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 3); adipose tissue: 18.4 nTPM (manageable, limit 5); tongue: 17.6 nTPM (protected, limit 3); spleen: 16.5 nTPM (manageable, limit 5); colon: 16.4 nTPM (protected, limit 3); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 3); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 3); midbrain: 13.4 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172785,ZNG1A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.7477% (minimum 95%, Missing); adrenal gland: 67.9487% (minimum 99%, Missing); amygdala: 64.6341% (minimum 99%, Missing); basal ganglia: 66.2500% (minimum 99%, Missing); bone marrow: 79.1045% (minimum 99%, Missing); cerebellum: 54.6392% (minimum 99%, Missing); cerebral cortex: 51.9608% (minimum 99%, Missing); choroid plexus: 57.6087% (minimum 99%, Missing); colon: 58.8889% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 59.5506% (minimum 97%, Missing); heart muscle: 75.7143% (minimum 99%, Missing); hippocampal formation: 65.4321% (minimum 99%, Missing); hypothalamus: 65.4321% (minimum 99%, Missing); kidney: 37.3239% (minimum 99%, Missing); liver: 38.9706% (minimum 99%, Missing); lung: 61.6279% (minimum 99%, Missing); lymph node: 67.9487% (minimum 97%, Missing); midbrain: 62.3529% (minimum 99%, Missing); pancreas: 54.6392% (minimum 99%, Missing); parathyroid gland: 47.3214% (minimum 97%, Missing); pituitary gland: 64.6341% (minimum 99%, Missing); rectum: 57.6087% (minimum 97%, Missing); retina: 52.4752% (minimum 99%, Missing); salivary gland: 60.2273% (minimum 97%, Missing); skeletal muscle: 67.9487% (minimum 99%, Missing); skin: 73.6111% (minimum 95%, Missing); small intestine: 63.0952% (minimum 99%, Missing); smooth muscle: 72.6027% (minimum 99%, Missing); spinal cord: 69.7368% (minimum 99%, Missing); spleen: 73.6111% (minimum 95%, Missing); stomach: 64.6341% (minimum 97%, Missing); thymus: 67.9487% (minimum 95%, Missing); thyroid gland: 37.0629% (minimum 95%, Missing); tongue: 57.6087% (minimum 97%, Missing); urinary bladder: 72.6027% (minimum 97%, Missing)",-0.579371,-0.496786,-0.616761,0,3,partial,8.9,5.9,9,"thyroid gland: 9 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); adipose tissue: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); tongue: 3.9 nTPM (protected, limit 2); choroid plexus: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172840,PDP2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.7477% (minimum 65%, Missing); adrenal gland: 67.9487% (minimum 75%, Missing); amygdala: 64.6341% (minimum 75%, Missing); basal ganglia: 66.2500% (minimum 75%, Missing); cerebellum: 54.6392% (minimum 75%, Missing); cerebral cortex: 51.9608% (minimum 75%, Missing); choroid plexus: 57.6087% (minimum 75%, Missing); colon: 58.8889% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 59.5506% (minimum 70%, Missing); hippocampal formation: 65.4321% (minimum 75%, Missing); hypothalamus: 65.4321% (minimum 75%, Missing); kidney: 37.3239% (minimum 75%, Missing); liver: 38.9706% (minimum 75%, Missing); lung: 61.6279% (minimum 75%, Missing); lymph node: 67.9487% (minimum 70%, Missing); midbrain: 62.3529% (minimum 75%, Missing); pancreas: 54.6392% (minimum 75%, Missing); parathyroid gland: 47.3214% (minimum 70%, Missing); pituitary gland: 64.6341% (minimum 75%, Missing); rectum: 57.6087% (minimum 70%, Missing); retina: 52.4752% (minimum 75%, Missing); salivary gland: 60.2273% (minimum 70%, Missing); skeletal muscle: 67.9487% (minimum 75%, Missing); small intestine: 63.0952% (minimum 75%, Missing); smooth muscle: 72.6027% (minimum 75%, Missing); spinal cord: 69.7368% (minimum 75%, Missing); stomach: 64.6341% (minimum 70%, Missing); thyroid gland: 37.0629% (minimum 65%, Missing); tongue: 57.6087% (minimum 70%, Missing)",-0.279371,-0.226786,-0.376761,0,3,partial,8.9,5.9,9,"thyroid gland: 9 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); adipose tissue: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); tongue: 3.9 nTPM (protected, limit 2); choroid plexus: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172840,PDP2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.7477% (minimum 65%, Missing); adrenal gland: 67.9487% (minimum 75%, Missing); amygdala: 64.6341% (minimum 75%, Missing); basal ganglia: 66.2500% (minimum 75%, Missing); cerebellum: 54.6392% (minimum 75%, Missing); cerebral cortex: 51.9608% (minimum 75%, Missing); choroid plexus: 57.6087% (minimum 75%, Missing); colon: 58.8889% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 59.5506% (minimum 70%, Missing); hippocampal formation: 65.4321% (minimum 75%, Missing); hypothalamus: 65.4321% (minimum 75%, Missing); kidney: 37.3239% (minimum 75%, Missing); liver: 38.9706% (minimum 75%, Missing); lung: 61.6279% (minimum 75%, Missing); lymph node: 67.9487% (minimum 70%, Missing); midbrain: 62.3529% (minimum 75%, Missing); pancreas: 54.6392% (minimum 75%, Missing); parathyroid gland: 47.3214% (minimum 70%, Missing); pituitary gland: 64.6341% (minimum 75%, Missing); rectum: 57.6087% (minimum 70%, Missing); retina: 52.4752% (minimum 75%, Missing); salivary gland: 60.2273% (minimum 70%, Missing); skeletal muscle: 67.9487% (minimum 75%, Missing); small intestine: 63.0952% (minimum 75%, Missing); smooth muscle: 72.6027% (minimum 75%, Missing); spinal cord: 69.7368% (minimum 75%, Missing); stomach: 64.6341% (minimum 70%, Missing); thyroid gland: 37.0629% (minimum 65%, Missing); tongue: 57.6087% (minimum 70%, Missing)",-0.279371,-0.226786,-0.376761,0,3,partial,8.9,5.9,9,"thyroid gland: 9 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); adipose tissue: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); tongue: 3.9 nTPM (protected, limit 3); choroid plexus: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); salivary gland: 3.5 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172840,PDP2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.7477% (minimum 65%, Missing); adrenal gland: 67.9487% (minimum 75%, Missing); amygdala: 64.6341% (minimum 75%, Missing); basal ganglia: 66.2500% (minimum 75%, Missing); cerebellum: 54.6392% (minimum 75%, Missing); cerebral cortex: 51.9608% (minimum 75%, Missing); choroid plexus: 57.6087% (minimum 75%, Missing); colon: 58.8889% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 59.5506% (minimum 70%, Missing); hippocampal formation: 65.4321% (minimum 75%, Missing); hypothalamus: 65.4321% (minimum 75%, Missing); kidney: 37.3239% (minimum 75%, Missing); liver: 38.9706% (minimum 75%, Missing); lung: 61.6279% (minimum 75%, Missing); lymph node: 67.9487% (minimum 70%, Missing); midbrain: 62.3529% (minimum 75%, Missing); pancreas: 54.6392% (minimum 75%, Missing); parathyroid gland: 47.3214% (minimum 70%, Missing); pituitary gland: 64.6341% (minimum 75%, Missing); rectum: 57.6087% (minimum 70%, Missing); retina: 52.4752% (minimum 75%, Missing); salivary gland: 60.2273% (minimum 70%, Missing); skeletal muscle: 67.9487% (minimum 75%, Missing); small intestine: 63.0952% (minimum 75%, Missing); smooth muscle: 72.6027% (minimum 75%, Missing); spinal cord: 69.7368% (minimum 75%, Missing); stomach: 64.6341% (minimum 70%, Missing); thyroid gland: 37.0629% (minimum 65%, Missing); tongue: 57.6087% (minimum 70%, Missing)",-0.279371,-0.226786,-0.376761,0,3,partial,8.9,5.9,9,"thyroid gland: 9 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); adipose tissue: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); tongue: 3.9 nTPM (protected, limit 3); choroid plexus: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); salivary gland: 3.5 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172840,PDP2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.7477% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 67.9487% (minimum 75%, Baseline (adaptation disabled)); amygdala: 64.6341% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.2500% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.6392% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.9608% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 57.6087% (minimum 75%, Baseline (adaptation disabled)); colon: 58.8889% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.5506% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 65.4321% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.4321% (minimum 75%, Baseline (adaptation disabled)); kidney: 37.3239% (minimum 75%, Baseline (adaptation disabled)); liver: 38.9706% (minimum 75%, Baseline (adaptation disabled)); lung: 61.6279% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.9487% (minimum 70%, Baseline (adaptation disabled)); midbrain: 62.3529% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.6392% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 47.3214% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 64.6341% (minimum 75%, Baseline (adaptation disabled)); rectum: 57.6087% (minimum 70%, Baseline (adaptation disabled)); retina: 52.4752% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.2273% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 67.9487% (minimum 75%, Baseline (adaptation disabled)); small intestine: 63.0952% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.6027% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.7368% (minimum 75%, Baseline (adaptation disabled)); stomach: 64.6341% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 37.0629% (minimum 65%, Baseline (adaptation disabled)); tongue: 57.6087% (minimum 70%, Baseline (adaptation disabled))",-0.279371,-0.226786,-0.376761,0,3,partial,8.9,5.9,9,"thyroid gland: 9 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); adipose tissue: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); tongue: 3.9 nTPM (protected, limit 3); choroid plexus: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); salivary gland: 3.5 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172840,PDP2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.7500% (minimum 99%, Missing)",0.0375,0.03,-0.0025,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172967,XKR3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.3375,0.3,0.2375,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172967,XKR3,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.3375,0.3,0.2375,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172967,XKR3,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.3375,0.3,0.2375,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172967,XKR3,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.3375,0.3,0.2375,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000172967,XKR3,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 91.8033% (minimum 99%, Missing); skeletal muscle: 86.5979% (minimum 99%, Missing)",0.0440828,0.03,-0.124021,0,80,unavailable,2.6,0,0.1,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173093,CCDC63,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344083,0.3,0.115979,0,80,unavailable,2.6,0,0.1,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173093,CCDC63,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344083,0.3,0.115979,0,80,unavailable,2.6,0,0.1,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173093,CCDC63,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344083,0.3,0.115979,0,80,unavailable,2.6,0,0.1,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173093,CCDC63,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344083,0.3,0.115979,0,80,unavailable,2.6,0,0.1,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173093,CCDC63,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 83.3333% (minimum 99%, Missing); retina: 45.4545% (minimum 99%, Missing)",0.05,0.03,-0.535455,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173157,ADAMTS20,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 45.4545% (minimum 75%, Missing)",0.35,0.3,-0.295455,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173157,ADAMTS20,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 45.4545% (minimum 75%, Missing)",0.35,0.3,-0.295455,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173157,ADAMTS20,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 45.4545% (minimum 75%, Missing)",0.35,0.3,-0.295455,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173157,ADAMTS20,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 45.4545% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.295455,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173157,ADAMTS20,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,,0.05,0.03,0.01,9,3,partial,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173213,TUBB8B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,9,3,partial,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173213,TUBB8B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,9,3,partial,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173213,TUBB8B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,9,3,partial,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173213,TUBB8B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,9,3,partial,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173213,TUBB8B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.0435% (minimum 95%, Missing); adrenal gland: 58.2734% (minimum 99%, Missing); amygdala: 81.0000% (minimum 99%, Missing); basal ganglia: 79.4118% (minimum 99%, Missing); bone marrow: 70.4348% (minimum 99%, Missing); cerebellum: 65.8537% (minimum 99%, Missing); cerebral cortex: 43.3155% (minimum 99%, Missing); choroid plexus: 51.5924% (minimum 99%, Missing); colon: 84.3750% (minimum 97%, Missing); duodenum: 90.0000% (minimum 99%, Missing); esophagus: 91.0112% (minimum 97%, Missing); heart muscle: 80.1980% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 77.1429% (minimum 99%, Missing); kidney: 79.4118% (minimum 99%, Missing); liver: 91.0112% (minimum 99%, Missing); lung: 83.5052% (minimum 99%, Missing); lymph node: 85.2632% (minimum 97%, Missing); midbrain: 77.1429% (minimum 99%, Missing); pancreas: 82.6531% (minimum 99%, Missing); parathyroid gland: 68.0672% (minimum 97%, Missing); pituitary gland: 58.2734% (minimum 99%, Missing); rectum: 92.0455% (minimum 97%, Missing); retina: 41.7526% (minimum 99%, Missing); salivary gland: 85.2632% (minimum 97%, Missing); skeletal muscle: 86.1702% (minimum 99%, Missing); skin: 83.5052% (minimum 95%, Missing); small intestine: 89.0110% (minimum 99%, Missing); smooth muscle: 78.6408% (minimum 99%, Missing); spinal cord: 74.3119% (minimum 99%, Missing); spleen: 78.6408% (minimum 95%, Missing); stomach: 86.1702% (minimum 97%, Missing); thymus: 89.0110% (minimum 95%, Missing); thyroid gland: 58.2734% (minimum 95%, Missing); tongue: 92.0455% (minimum 97%, Missing); urinary bladder: 86.1702% (minimum 97%, Missing)",-0.367266,-0.289328,-0.572474,0,80,unavailable,11.3,3.8,5.8,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173258,ZNF483,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.2734% (minimum 75%, Missing); bone marrow: 70.4348% (minimum 75%, Missing); cerebellum: 65.8537% (minimum 75%, Missing); cerebral cortex: 43.3155% (minimum 75%, Missing); choroid plexus: 51.5924% (minimum 75%, Missing); parathyroid gland: 68.0672% (minimum 70%, Missing); pituitary gland: 58.2734% (minimum 75%, Missing); retina: 41.7526% (minimum 75%, Missing); spinal cord: 74.3119% (minimum 75%, Missing); thyroid gland: 58.2734% (minimum 65%, Missing)",-0.0672662,-0.0193277,-0.332474,0,80,unavailable,11.3,3.8,5.8,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173258,ZNF483,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.2734% (minimum 75%, Missing); bone marrow: 70.4348% (minimum 75%, Missing); cerebellum: 65.8537% (minimum 75%, Missing); cerebral cortex: 43.3155% (minimum 75%, Missing); choroid plexus: 51.5924% (minimum 75%, Missing); parathyroid gland: 68.0672% (minimum 70%, Missing); pituitary gland: 58.2734% (minimum 75%, Missing); retina: 41.7526% (minimum 75%, Missing); spinal cord: 74.3119% (minimum 75%, Missing); thyroid gland: 58.2734% (minimum 65%, Missing)",-0.0672662,-0.0193277,-0.332474,0,80,unavailable,11.3,3.8,5.8,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173258,ZNF483,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.2734% (minimum 75%, Missing); bone marrow: 70.4348% (minimum 75%, Missing); cerebellum: 65.8537% (minimum 75%, Missing); cerebral cortex: 43.3155% (minimum 75%, Missing); choroid plexus: 51.5924% (minimum 75%, Missing); parathyroid gland: 68.0672% (minimum 70%, Missing); pituitary gland: 58.2734% (minimum 75%, Missing); retina: 41.7526% (minimum 75%, Missing); spinal cord: 74.3119% (minimum 75%, Missing); thyroid gland: 58.2734% (minimum 65%, Missing)",-0.0672662,-0.0193277,-0.332474,0,80,unavailable,11.3,3.8,5.8,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173258,ZNF483,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.2734% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 70.4348% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.8537% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 43.3155% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 51.5924% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 68.0672% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.2734% (minimum 75%, Baseline (adaptation disabled)); retina: 41.7526% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.3119% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 58.2734% (minimum 65%, Baseline (adaptation disabled))",-0.0672662,-0.0193277,-0.332474,0,80,unavailable,11.3,3.8,5.8,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173258,ZNF483,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.3516% (minimum 99%, Missing); amygdala: 94.2105% (minimum 99%, Missing); basal ganglia: 93.2292% (minimum 99%, Missing); cerebellum: 89.9497% (minimum 99%, Missing); cerebral cortex: 93.2292% (minimum 99%, Missing); choroid plexus: 98.8950% (minimum 99%, Missing); heart muscle: 98.3516% (minimum 99%, Missing); hippocampal formation: 92.2680% (minimum 99%, Missing); hypothalamus: 93.2292% (minimum 99%, Missing); kidney: 97.8142% (minimum 99%, Missing); liver: 95.2128% (minimum 99%, Missing); lung: 98.8950% (minimum 99%, Missing); midbrain: 92.2680% (minimum 99%, Missing); pancreas: 97.2826% (minimum 99%, Missing); pituitary gland: 96.2366% (minimum 99%, Missing); retina: 96.2366% (minimum 99%, Missing); skeletal muscle: 97.8142% (minimum 99%, Missing); small intestine: 98.3516% (minimum 99%, Missing); spinal cord: 88.1773% (minimum 99%, Missing)",0.00721925,0.00814208,-0.108227,0,80,unavailable,2.4,0.4,0.8,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173261,PLAC8L1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.307219,0.278142,0.131773,0,80,unavailable,2.4,0.4,0.8,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173261,PLAC8L1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.307219,0.278142,0.131773,0,80,unavailable,2.4,0.4,0.8,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173261,PLAC8L1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.307219,0.278142,0.131773,0,80,unavailable,2.4,0.4,0.8,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173261,PLAC8L1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.307219,0.278142,0.131773,0,80,unavailable,2.4,0.4,0.8,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173261,PLAC8L1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.5218% (minimum 99%, Missing); bone marrow: 92.7570% (minimum 99%, Missing); liver: 96.4763% (minimum 97%, Supported); pancreas: 92.5408% (minimum 97%, Supported); retina: 98.3891% (minimum 99%, Missing)",0.0474874,0.03,-0.0624299,0,9,partial,6.4,1.5,1.8,"pancreas: 6.4 nTPM (vital, limit 3); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173262,SLC2A14,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347487,0.3,0.17757,0,9,partial,6.4,1.5,1.8,"pancreas: 6.4 nTPM (vital, limit 3); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173262,SLC2A14,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347487,0.3,0.17757,0,9,partial,6.4,1.5,1.8,"pancreas: 6.4 nTPM (vital, limit 3); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173262,SLC2A14,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347487,0.3,0.17757,0,9,partial,6.4,1.5,1.8,"pancreas: 6.4 nTPM (vital, limit 3); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173262,SLC2A14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327833,0.281459,0.175408,0,9,partial,6.4,1.5,1.8,"pancreas: 6.4 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173262,SLC2A14,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 95.0000% (minimum 99%, Missing)",0.05,0.03,-0.04,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173335,CST9,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.2,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173335,CST9,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.2,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173335,CST9,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.2,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173335,CST9,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.2,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173335,CST9,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173389,IQCF1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173389,IQCF1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173389,IQCF1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173389,IQCF1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173389,IQCF1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.0268454,0.000595611,0,2,partial,0.4,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173401,GLIPR1L1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296845,0.240596,0,2,partial,0.4,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173401,GLIPR1L1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296845,0.240596,0,2,partial,0.4,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173401,GLIPR1L1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.296845,0.240596,0,2,partial,0.4,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173401,GLIPR1L1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.334424,0.290596,0.2375,0,2,partial,0.4,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173401,GLIPR1L1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.2361% (minimum 90%, Approved); adrenal gland: 94.8339% (minimum 98%, Approved); choroid plexus: 95.1852% (minimum 99%, Missing); heart muscle: 95.8955% (minimum 98%, Approved); retina: 97.3485% (minimum 99%, Missing); skeletal muscle: 96.9811% (minimum 98%, Approved); smooth muscle: 96.6165% (minimum 98%, Approved); tongue: 96.9811% (minimum 97%, Missing)",-0.00763889,-0.000188679,-0.0381481,0,3,partial,1.4,1.1,3.1,"choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173421,IHO1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.292361,0.269811,0.201852,0,3,partial,1.4,1.1,3.1,"choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173421,IHO1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.292361,0.269811,0.201852,0,3,partial,1.4,1.1,3.1,"choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173421,IHO1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.292361,0.269811,0.201852,0,3,partial,1.4,1.1,3.1,"choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173421,IHO1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.242361,0.258955,0.198339,0,3,partial,1.4,1.1,3.1,"adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173421,IHO1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.2,53.2,0.2,"salivary gland: 53.2 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173431,RNASE8,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.2,53.2,0.2,"salivary gland: 53.2 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173431,RNASE8,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.2,53.2,0.2,"salivary gland: 53.2 nTPM (protected, limit 3)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173431,RNASE8,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.2,53.2,0.2,"salivary gland: 53.2 nTPM (protected, limit 3)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173431,RNASE8,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.2,53.2,0.2,"salivary gland: 53.2 nTPM (protected, limit 3)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173431,RNASE8,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.1722% (minimum 95%, Missing); adrenal gland: 41.1215% (minimum 99%, Missing); amygdala: 80.7339% (minimum 99%, Missing); basal ganglia: 81.1060% (minimum 99%, Missing); bone marrow: 54.6584% (minimum 99%, Missing); cerebellum: 73.3333% (minimum 98%, Approved); cerebral cortex: 78.2222% (minimum 99%, Missing); choroid plexus: 84.6154% (minimum 99%, Missing); colon: 81.4815% (minimum 97%, Missing); duodenum: 76.1905% (minimum 99%, Missing); esophagus: 73.3333% (minimum 97%, Missing); heart muscle: 77.8761% (minimum 99%, Missing); hippocampal formation: 81.1060% (minimum 99%, Missing); hypothalamus: 78.2222% (minimum 99%, Missing); kidney: 76.5217% (minimum 99%, Missing); liver: 80.3653% (minimum 99%, Missing); lung: 79.2793% (minimum 99%, Missing); lymph node: 69.5652% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 82.6291% (minimum 99%, Missing); parathyroid gland: 84.2105% (minimum 97%, Missing); pituitary gland: 61.9718% (minimum 99%, Missing); rectum: 76.1905% (minimum 97%, Missing); retina: 61.7544% (minimum 99%, Missing); salivary gland: 79.2793% (minimum 97%, Missing); skeletal muscle: 78.5714% (minimum 99%, Missing); skin: 76.1905% (minimum 95%, Missing); small intestine: 81.1060% (minimum 99%, Missing); smooth muscle: 80.3653% (minimum 98%, Approved); spinal cord: 75.8621% (minimum 99%, Missing); spleen: 77.8761% (minimum 90%, Approved); stomach: 73.9496% (minimum 97%, Missing); thymus: 76.8559% (minimum 95%, Missing); thyroid gland: 80.0000% (minimum 95%, Missing); tongue: 76.5217% (minimum 97%, Missing); urinary bladder: 39.2857% (minimum 95%, Approved)",-0.418278,-0.557143,-0.578785,0,5,partial,25.2,27.2,15.5,"urinary bladder: 27.2 nTPM (protected, limit 4); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (manageable, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 2); esophagus: 6.4 nTPM (protected, limit 2); stomach: 6.2 nTPM (protected, limit 2); spinal cord: 5.6 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); midbrain: 4.4 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 2); liver: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); pancreas: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173451,THAP2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.1722% (minimum 65%, Missing); adrenal gland: 41.1215% (minimum 75%, Missing); bone marrow: 54.6584% (minimum 75%, Missing); lymph node: 69.5652% (minimum 70%, Missing); pituitary gland: 61.9718% (minimum 75%, Missing); retina: 61.7544% (minimum 75%, Missing); urinary bladder: 39.2857% (minimum 65%, Approved)",-0.118278,-0.257143,-0.338785,0,5,partial,25.2,27.2,15.5,"urinary bladder: 27.2 nTPM (protected, limit 4); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (manageable, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 2); esophagus: 6.4 nTPM (protected, limit 2); stomach: 6.2 nTPM (protected, limit 2); spinal cord: 5.6 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); midbrain: 4.4 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 2); liver: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); pancreas: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173451,THAP2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.1722% (minimum 65%, Missing); adrenal gland: 41.1215% (minimum 75%, Missing); bone marrow: 54.6584% (minimum 75%, Missing); lymph node: 69.5652% (minimum 70%, Missing); pituitary gland: 61.9718% (minimum 75%, Missing); retina: 61.7544% (minimum 75%, Missing); urinary bladder: 39.2857% (minimum 65%, Approved)",-0.118278,-0.257143,-0.338785,0,5,partial,25.2,27.2,15.5,"urinary bladder: 27.2 nTPM (protected, limit 4); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (manageable, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 2); esophagus: 6.4 nTPM (protected, limit 3); stomach: 6.2 nTPM (protected, limit 3); spinal cord: 5.6 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 3); midbrain: 4.4 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 2); liver: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); pancreas: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173451,THAP2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.1722% (minimum 65%, Missing); adrenal gland: 41.1215% (minimum 75%, Missing); bone marrow: 54.6584% (minimum 75%, Missing); lymph node: 69.5652% (minimum 70%, Missing); pituitary gland: 61.9718% (minimum 75%, Missing); retina: 61.7544% (minimum 75%, Missing); urinary bladder: 39.2857% (minimum 65%, Approved)",-0.118278,-0.257143,-0.338785,0,5,partial,25.2,27.2,15.5,"urinary bladder: 27.2 nTPM (protected, limit 4); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (manageable, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 2); esophagus: 6.4 nTPM (protected, limit 3); stomach: 6.2 nTPM (protected, limit 3); spinal cord: 5.6 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 3); midbrain: 4.4 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 2); liver: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); pancreas: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173451,THAP2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.1722% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 41.1215% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 54.6584% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.3333% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.5652% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 61.9718% (minimum 75%, Baseline (adaptation disabled)); retina: 61.7544% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 39.2857% (minimum 70%, Baseline (adaptation disabled))",-0.118278,-0.307143,-0.338785,0,5,partial,25.2,27.2,15.5,"urinary bladder: 27.2 nTPM (protected, limit 3); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (manageable, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 3); stomach: 6.2 nTPM (protected, limit 3); spinal cord: 5.6 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 3); midbrain: 4.4 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); pancreas: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173451,THAP2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.0098446,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173464,RNASE11,admission_only,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249845,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173464,RNASE11,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249845,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173464,RNASE11,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249845,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173464,RNASE11,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249845,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173464,RNASE11,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.9925% (minimum 99%, Missing); basal ganglia: 96.2687% (minimum 99%, Missing); choroid plexus: 75.2187% (minimum 99%, Missing); hippocampal formation: 96.2687% (minimum 99%, Missing); hypothalamus: 91.8149% (minimum 99%, Missing); midbrain: 96.9925% (minimum 99%, Missing); pituitary gland: 97.3585% (minimum 99%, Missing); spinal cord: 98.4733% (minimum 99%, Missing)",0.05,0.00727273,-0.237813,0,4,partial,8.5,4.6,1.1,"choroid plexus: 8.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173557,CIMIP2C,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.277273,0.00218659,0,4,partial,8.5,4.6,1.1,"choroid plexus: 8.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173557,CIMIP2C,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.277273,0.00218659,0,4,partial,8.5,4.6,1.1,"choroid plexus: 8.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173557,CIMIP2C,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.277273,0.00218659,0,4,partial,8.5,4.6,1.1,"choroid plexus: 8.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173557,CIMIP2C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.309108,0.148684,0.00218659,0,4,partial,8.5,4.6,1.1,"choroid plexus: 8.5 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); hypothalamus: 2.3 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173557,CIMIP2C,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.4103% (minimum 95%, Missing); adrenal gland: 46.8085% (minimum 99%, Missing); amygdala: 48.8889% (minimum 99%, Missing); basal ganglia: 39.2857% (minimum 99%, Missing); bone marrow: 44.0000% (minimum 99%, Missing); cerebellum: 41.5094% (minimum 99%, Missing); cerebral cortex: 24.1758% (minimum 99%, Missing); choroid plexus: 50.0000% (minimum 99%, Missing); colon: 55.0000% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 62.8571% (minimum 97%, Missing); heart muscle: 62.8571% (minimum 99%, Missing); hippocampal formation: 48.8889% (minimum 99%, Missing); hypothalamus: 45.8333% (minimum 99%, Missing); kidney: 61.1111% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Missing); lung: 41.5094% (minimum 99%, Missing); lymph node: 44.0000% (minimum 97%, Missing); midbrain: 61.1111% (minimum 99%, Missing); pancreas: 56.4103% (minimum 99%, Missing); parathyroid gland: 59.4595% (minimum 97%, Missing); pituitary gland: 57.8947% (minimum 99%, Missing); rectum: 56.4103% (minimum 97%, Missing); retina: 23.4043% (minimum 99%, Missing); salivary gland: 62.8571% (minimum 97%, Missing); skeletal muscle: 57.8947% (minimum 99%, Missing); skin: 48.8889% (minimum 95%, Missing); small intestine: 59.4595% (minimum 99%, Missing); smooth muscle: 62.8571% (minimum 99%, Missing); spinal cord: 62.8571% (minimum 99%, Missing); spleen: 53.6585% (minimum 95%, Missing); stomach: 59.4595% (minimum 97%, Missing); thymus: 16.7939% (minimum 95%, Missing); thyroid gland: 55.0000% (minimum 95%, Missing); tongue: 70.9677% (minimum 97%, Missing); urinary bladder: 59.4595% (minimum 97%, Missing)",-0.782061,-0.53,-0.755957,0,4,partial,7.2,2.8,10.9,"thymus: 10.9 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173611,SCAI,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.4103% (minimum 65%, Missing); adrenal gland: 46.8085% (minimum 75%, Missing); amygdala: 48.8889% (minimum 75%, Missing); basal ganglia: 39.2857% (minimum 75%, Missing); bone marrow: 44.0000% (minimum 75%, Missing); cerebellum: 41.5094% (minimum 75%, Missing); cerebral cortex: 24.1758% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 62.8571% (minimum 70%, Missing); heart muscle: 62.8571% (minimum 75%, Missing); hippocampal formation: 48.8889% (minimum 75%, Missing); hypothalamus: 45.8333% (minimum 75%, Missing); kidney: 61.1111% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 41.5094% (minimum 75%, Missing); lymph node: 44.0000% (minimum 70%, Missing); midbrain: 61.1111% (minimum 75%, Missing); pancreas: 56.4103% (minimum 75%, Missing); parathyroid gland: 59.4595% (minimum 70%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); rectum: 56.4103% (minimum 70%, Missing); retina: 23.4043% (minimum 75%, Missing); salivary gland: 62.8571% (minimum 70%, Missing); skeletal muscle: 57.8947% (minimum 75%, Missing); skin: 48.8889% (minimum 65%, Missing); small intestine: 59.4595% (minimum 75%, Missing); smooth muscle: 62.8571% (minimum 75%, Missing); spinal cord: 62.8571% (minimum 75%, Missing); spleen: 53.6585% (minimum 65%, Missing); stomach: 59.4595% (minimum 70%, Missing); thymus: 16.7939% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); urinary bladder: 59.4595% (minimum 70%, Missing)",-0.482061,-0.26,-0.515957,0,4,partial,7.2,2.8,10.9,"thymus: 10.9 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173611,SCAI,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.4103% (minimum 65%, Missing); adrenal gland: 46.8085% (minimum 75%, Missing); amygdala: 48.8889% (minimum 75%, Missing); basal ganglia: 39.2857% (minimum 75%, Missing); bone marrow: 44.0000% (minimum 75%, Missing); cerebellum: 41.5094% (minimum 75%, Missing); cerebral cortex: 24.1758% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 62.8571% (minimum 70%, Missing); heart muscle: 62.8571% (minimum 75%, Missing); hippocampal formation: 48.8889% (minimum 75%, Missing); hypothalamus: 45.8333% (minimum 75%, Missing); kidney: 61.1111% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 41.5094% (minimum 75%, Missing); lymph node: 44.0000% (minimum 70%, Missing); midbrain: 61.1111% (minimum 75%, Missing); pancreas: 56.4103% (minimum 75%, Missing); parathyroid gland: 59.4595% (minimum 70%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); rectum: 56.4103% (minimum 70%, Missing); retina: 23.4043% (minimum 75%, Missing); salivary gland: 62.8571% (minimum 70%, Missing); skeletal muscle: 57.8947% (minimum 75%, Missing); skin: 48.8889% (minimum 65%, Missing); small intestine: 59.4595% (minimum 75%, Missing); smooth muscle: 62.8571% (minimum 75%, Missing); spinal cord: 62.8571% (minimum 75%, Missing); spleen: 53.6585% (minimum 65%, Missing); stomach: 59.4595% (minimum 70%, Missing); thymus: 16.7939% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); urinary bladder: 59.4595% (minimum 70%, Missing)",-0.482061,-0.26,-0.515957,0,4,partial,7.2,2.8,10.9,"thymus: 10.9 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173611,SCAI,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.4103% (minimum 65%, Missing); adrenal gland: 46.8085% (minimum 75%, Missing); amygdala: 48.8889% (minimum 75%, Missing); basal ganglia: 39.2857% (minimum 75%, Missing); bone marrow: 44.0000% (minimum 75%, Missing); cerebellum: 41.5094% (minimum 75%, Missing); cerebral cortex: 24.1758% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 62.8571% (minimum 70%, Missing); heart muscle: 62.8571% (minimum 75%, Missing); hippocampal formation: 48.8889% (minimum 75%, Missing); hypothalamus: 45.8333% (minimum 75%, Missing); kidney: 61.1111% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 41.5094% (minimum 75%, Missing); lymph node: 44.0000% (minimum 70%, Missing); midbrain: 61.1111% (minimum 75%, Missing); pancreas: 56.4103% (minimum 75%, Missing); parathyroid gland: 59.4595% (minimum 70%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); rectum: 56.4103% (minimum 70%, Missing); retina: 23.4043% (minimum 75%, Missing); salivary gland: 62.8571% (minimum 70%, Missing); skeletal muscle: 57.8947% (minimum 75%, Missing); skin: 48.8889% (minimum 65%, Missing); small intestine: 59.4595% (minimum 75%, Missing); smooth muscle: 62.8571% (minimum 75%, Missing); spinal cord: 62.8571% (minimum 75%, Missing); spleen: 53.6585% (minimum 65%, Missing); stomach: 59.4595% (minimum 70%, Missing); thymus: 16.7939% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); urinary bladder: 59.4595% (minimum 70%, Missing)",-0.482061,-0.26,-0.515957,0,4,partial,7.2,2.8,10.9,"thymus: 10.9 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173611,SCAI,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.4103% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 46.8085% (minimum 75%, Baseline (adaptation disabled)); amygdala: 48.8889% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 39.2857% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 44.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 41.5094% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 24.1758% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 50.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 55.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.8571% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 62.8571% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 48.8889% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 45.8333% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.1111% (minimum 75%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 75%, Baseline (adaptation disabled)); lung: 41.5094% (minimum 75%, Baseline (adaptation disabled)); lymph node: 44.0000% (minimum 70%, Baseline (adaptation disabled)); midbrain: 61.1111% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.4103% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.4595% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 57.8947% (minimum 75%, Baseline (adaptation disabled)); rectum: 56.4103% (minimum 70%, Baseline (adaptation disabled)); retina: 23.4043% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.8571% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 57.8947% (minimum 75%, Baseline (adaptation disabled)); skin: 48.8889% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.4595% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.8571% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.8571% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.6585% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.4595% (minimum 70%, Baseline (adaptation disabled)); thymus: 16.7939% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.0000% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 59.4595% (minimum 70%, Baseline (adaptation disabled))",-0.482061,-0.26,-0.515957,0,4,partial,7.2,2.8,10.9,"thymus: 10.9 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173611,SCAI,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.0682% (minimum 95%, Enhanced); amygdala: 53.6232% (minimum 99%, Missing); basal ganglia: 60.9890% (minimum 99%, Missing); bone marrow: 85.3846% (minimum 95%, Enhanced); cerebellum: 35.6340% (minimum 99%, Missing); cerebral cortex: 48.0519% (minimum 99%, Missing); choroid plexus: 96.1039% (minimum 99%, Missing); colon: 60.6557% (minimum 80%, Enhanced); duodenum: 94.0678% (minimum 95%, Enhanced); esophagus: 74.0000% (minimum 80%, Enhanced); heart muscle: 65.1026% (minimum 95%, Enhanced); hippocampal formation: 53.7530% (minimum 99%, Missing); hypothalamus: 61.4958% (minimum 99%, Missing); kidney: 65.4867% (minimum 99%, Missing); liver: 89.8785% (minimum 95%, Enhanced); lung: 73.2673% (minimum 95%, Enhanced); midbrain: 72.5490% (minimum 99%, Missing); pancreas: 88.4462% (minimum 95%, Enhanced); pituitary gland: 74.2475% (minimum 99%, Missing); retina: 97.7974% (minimum 99%, Missing); salivary gland: 71.3826% (minimum 80%, Enhanced); skeletal muscle: 70.4762% (minimum 95%, Enhanced); small intestine: 79.5699% (minimum 95%, Enhanced); spinal cord: 74.2475% (minimum 99%, Missing); stomach: 73.2673% (minimum 97%, Missing); thymus: 94.8718% (minimum 95%, Missing); tongue: 92.1162% (minimum 97%, Missing); urinary bladder: 71.3826% (minimum 80%, Enhanced)",-0.00128205,-0.237327,-0.63366,0,4,partial,40.1,14.4,14.8,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); colon: 14.4 nTPM (protected, limit 12); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 6); heart muscle: 11.9 nTPM (vital, limit 6); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 6); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 6); stomach: 8.1 nTPM (protected, limit 2); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173621,LRFN4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 53.6232% (minimum 75%, Missing); basal ganglia: 60.9890% (minimum 75%, Missing); cerebellum: 35.6340% (minimum 75%, Missing); cerebral cortex: 48.0519% (minimum 75%, Missing); hippocampal formation: 53.7530% (minimum 75%, Missing); hypothalamus: 61.4958% (minimum 75%, Missing); kidney: 65.4867% (minimum 75%, Missing); midbrain: 72.5490% (minimum 75%, Missing); pituitary gland: 74.2475% (minimum 75%, Missing); spinal cord: 74.2475% (minimum 75%, Missing)",0.1,0.0326733,-0.39366,0,4,partial,40.1,14.4,14.8,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); colon: 14.4 nTPM (protected, limit 12); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 6); heart muscle: 11.9 nTPM (vital, limit 6); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 6); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 6); stomach: 8.1 nTPM (protected, limit 2); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173621,LRFN4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 53.6232% (minimum 75%, Missing); basal ganglia: 60.9890% (minimum 75%, Missing); cerebellum: 35.6340% (minimum 75%, Missing); cerebral cortex: 48.0519% (minimum 75%, Missing); hippocampal formation: 53.7530% (minimum 75%, Missing); hypothalamus: 61.4958% (minimum 75%, Missing); kidney: 65.4867% (minimum 75%, Missing); midbrain: 72.5490% (minimum 75%, Missing); pituitary gland: 74.2475% (minimum 75%, Missing); spinal cord: 74.2475% (minimum 75%, Missing)",0.1,0.0326733,-0.39366,0,4,partial,40.1,14.4,14.8,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); colon: 14.4 nTPM (protected, limit 12); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 6); heart muscle: 11.9 nTPM (vital, limit 6); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 6); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 6); stomach: 8.1 nTPM (protected, limit 3); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173621,LRFN4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 53.6232% (minimum 75%, Missing); basal ganglia: 60.9890% (minimum 75%, Missing); cerebellum: 35.6340% (minimum 75%, Missing); cerebral cortex: 48.0519% (minimum 75%, Missing); hippocampal formation: 53.7530% (minimum 75%, Missing); hypothalamus: 61.4958% (minimum 75%, Missing); kidney: 65.4867% (minimum 75%, Missing); midbrain: 72.5490% (minimum 75%, Missing); pituitary gland: 74.2475% (minimum 75%, Missing); spinal cord: 74.2475% (minimum 75%, Missing)",0.1,0.0326733,-0.39366,0,4,partial,40.1,14.4,14.8,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); colon: 14.4 nTPM (protected, limit 12); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 6); heart muscle: 11.9 nTPM (vital, limit 6); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 6); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 6); stomach: 8.1 nTPM (protected, limit 3); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173621,LRFN4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.0682% (minimum 75%, Baseline (adaptation disabled)); amygdala: 53.6232% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.9890% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 35.6340% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.0519% (minimum 75%, Baseline (adaptation disabled)); colon: 60.6557% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.1026% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 53.7530% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.4958% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.4867% (minimum 75%, Baseline (adaptation disabled)); lung: 73.2673% (minimum 75%, Baseline (adaptation disabled)); midbrain: 72.5490% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 74.2475% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 70.4762% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.2475% (minimum 75%, Baseline (adaptation disabled))",-0.05,-0.0934426,-0.39366,0,4,partial,40.1,14.4,14.8,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); adipose tissue: 14.8 nTPM (manageable, limit 5); colon: 14.4 nTPM (protected, limit 3); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); heart muscle: 11.9 nTPM (vital, limit 1); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); salivary gland: 8.9 nTPM (protected, limit 3); urinary bladder: 8.9 nTPM (protected, limit 3); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 1); stomach: 8.1 nTPM (protected, limit 3); esophagus: 7.8 nTPM (protected, limit 3); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); bone marrow: 3.8 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173621,LRFN4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 92.5620% (minimum 99%, Missing); lung: 91.0569% (minimum 99%, Missing)",0.05,0.0211504,-0.0794309,0,80,unavailable,1.1,0.1,0,"lung: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173627,APOBEC4,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.29115,0.160569,0,80,unavailable,1.1,0.1,0,"lung: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173627,APOBEC4,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.29115,0.160569,0,80,unavailable,1.1,0.1,0,"lung: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173627,APOBEC4,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.29115,0.160569,0,80,unavailable,1.1,0.1,0,"lung: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173627,APOBEC4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.29115,0.160569,0,80,unavailable,1.1,0.1,0,"lung: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173627,APOBEC4,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 12.5000% (minimum 95%, Missing)",-0.825,0.03,0.01,0,80,unavailable,0,0,0.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173673,HES3,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 12.5000% (minimum 65%, Missing)",-0.525,0.3,0.25,0,80,unavailable,0,0,0.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173673,HES3,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 12.5000% (minimum 65%, Missing)",-0.525,0.3,0.25,0,80,unavailable,0,0,0.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173673,HES3,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 12.5000% (minimum 65%, Missing)",-0.525,0.3,0.25,0,80,unavailable,0,0,0.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173673,HES3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 12.5000% (minimum 65%, Baseline (adaptation disabled))",-0.525,0.3,0.25,0,80,unavailable,0,0,0.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173673,HES3,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00825683,0,1,partial,0.3,0.2,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173699,SPATA3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248257,0,1,partial,0.3,0.2,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173699,SPATA3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248257,0,1,partial,0.3,0.2,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173699,SPATA3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248257,0,1,partial,0.3,0.2,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173699,SPATA3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349418,0.298837,0.248257,0,1,partial,0.3,0.2,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173699,SPATA3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"cerebellum: 98.6760% (minimum 99%, Missing); choroid plexus: 11.0868% (minimum 99%, Missing); pituitary gland: 98.4701% (minimum 99%, Missing); skeletal muscle: 98.5386% (minimum 99%, Missing)",0.0436842,0.0229874,-0.879132,0,80,unavailable,1135.6,1,0.9,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000173714,WFIKKN2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 11.0868% (minimum 75%, Missing)",0.343684,0.292987,-0.639132,0,80,unavailable,1135.6,1,0.9,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000173714,WFIKKN2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 11.0868% (minimum 75%, Missing)",0.343684,0.292987,-0.639132,0,80,unavailable,1135.6,1,0.9,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000173714,WFIKKN2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 11.0868% (minimum 75%, Missing)",0.343684,0.292987,-0.639132,0,80,unavailable,1135.6,1,0.9,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000173714,WFIKKN2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 11.0868% (minimum 75%, Baseline (adaptation disabled))",0.343684,0.292987,-0.639132,0,80,unavailable,1135.6,1,0.9,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000173714,WFIKKN2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.05,0.0155072,0.01,0,80,unavailable,0,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173728,SPMIP3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.285507,0.25,0,80,unavailable,0,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173728,SPMIP3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.285507,0.25,0,80,unavailable,0,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173728,SPMIP3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.285507,0.25,0,80,unavailable,0,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173728,SPMIP3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.285507,0.25,0,80,unavailable,0,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173728,SPMIP3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173769,TOPAZ1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173769,TOPAZ1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173769,TOPAZ1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173769,TOPAZ1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173769,TOPAZ1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 95.8621% (minimum 99%, Missing); hypothalamus: 98.5816% (minimum 99%, Missing); retina: 98.5816% (minimum 99%, Missing); skin: 94.5578% (minimum 95%, Missing); small intestine: 97.2028% (minimum 99%, Missing)",-0.00442177,0.0158156,-0.0313793,0,80,unavailable,0.6,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173809,TDRD12,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.295578,0.285816,0.208621,0,80,unavailable,0.6,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173809,TDRD12,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.295578,0.285816,0.208621,0,80,unavailable,0.6,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173809,TDRD12,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.295578,0.285816,0.208621,0,80,unavailable,0.6,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173809,TDRD12,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.295578,0.285816,0.208621,0,80,unavailable,0.6,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173809,TDRD12,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 71.2963% (minimum 95%, Missing); adrenal gland: 74.0385% (minimum 99%, Missing); amygdala: 69.3694% (minimum 99%, Missing); basal ganglia: 64.1667% (minimum 99%, Missing); bone marrow: 82.5000% (minimum 99%, Missing); cerebellum: 66.9565% (minimum 99%, Missing); cerebral cortex: 65.6250% (minimum 99%, Missing); choroid plexus: 72.4138% (minimum 99%, Missing); colon: 68.5460% (minimum 97%, Missing); duodenum: 79.1096% (minimum 99%, Missing); esophagus: 71.9626% (minimum 97%, Missing); heart muscle: 78.0405% (minimum 99%, Missing); hippocampal formation: 69.3694% (minimum 99%, Missing); hypothalamus: 68.7500% (minimum 99%, Missing); kidney: 60.3133% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Missing); lung: 71.0769% (minimum 99%, Missing); lymph node: 81.9149% (minimum 97%, Missing); midbrain: 73.8019% (minimum 99%, Missing); pancreas: 69.3694% (minimum 99%, Missing); parathyroid gland: 80.4878% (minimum 97%, Missing); pituitary gland: 71.9626% (minimum 99%, Missing); rectum: 83.6957% (minimum 97%, Missing); retina: 47.5309% (minimum 99%, Missing); salivary gland: 69.5783% (minimum 97%, Missing); skeletal muscle: 65.4391% (minimum 99%, Missing); skin: 61.4362% (minimum 95%, Missing); small intestine: 72.1875% (minimum 99%, Missing); smooth muscle: 82.7957% (minimum 99%, Missing); spinal cord: 71.2963% (minimum 99%, Missing); spleen: 63.8122% (minimum 95%, Missing); stomach: 71.5170% (minimum 97%, Missing); thymus: 81.9149% (minimum 95%, Missing); thyroid gland: 72.1875% (minimum 95%, Missing); tongue: 81.3380% (minimum 97%, Missing); urinary bladder: 71.9626% (minimum 97%, Missing)",-0.335638,-0.28454,-0.514691,0,80,unavailable,25.5,10.6,14.5,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); skin: 14.5 nTPM (manageable, limit 5); spleen: 13.1 nTPM (manageable, limit 5); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 2); hypothalamus: 10.5 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); stomach: 9.2 nTPM (protected, limit 2); pituitary gland: 9 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); small intestine: 8.9 nTPM (vital, limit 1); thyroid gland: 8.9 nTPM (manageable, limit 5); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 2); tongue: 5.3 nTPM (protected, limit 2); lymph node: 5.1 nTPM (protected, limit 2); thymus: 5.1 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173818,ENDOV,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.0385% (minimum 75%, Missing); amygdala: 69.3694% (minimum 75%, Missing); basal ganglia: 64.1667% (minimum 75%, Missing); cerebellum: 66.9565% (minimum 75%, Missing); cerebral cortex: 65.6250% (minimum 75%, Missing); choroid plexus: 72.4138% (minimum 75%, Missing); colon: 68.5460% (minimum 70%, Missing); hippocampal formation: 69.3694% (minimum 75%, Missing); hypothalamus: 68.7500% (minimum 75%, Missing); kidney: 60.3133% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 71.0769% (minimum 75%, Missing); midbrain: 73.8019% (minimum 75%, Missing); pancreas: 69.3694% (minimum 75%, Missing); pituitary gland: 71.9626% (minimum 75%, Missing); retina: 47.5309% (minimum 75%, Missing); salivary gland: 69.5783% (minimum 70%, Missing); skeletal muscle: 65.4391% (minimum 75%, Missing); skin: 61.4362% (minimum 65%, Missing); small intestine: 72.1875% (minimum 75%, Missing); spinal cord: 71.2963% (minimum 75%, Missing); spleen: 63.8122% (minimum 65%, Missing)",-0.0356383,-0.0145401,-0.274691,0,80,unavailable,25.5,10.6,14.5,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); skin: 14.5 nTPM (manageable, limit 5); spleen: 13.1 nTPM (manageable, limit 5); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 2); hypothalamus: 10.5 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); stomach: 9.2 nTPM (protected, limit 2); pituitary gland: 9 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); small intestine: 8.9 nTPM (vital, limit 1); thyroid gland: 8.9 nTPM (manageable, limit 5); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 2); tongue: 5.3 nTPM (protected, limit 2); lymph node: 5.1 nTPM (protected, limit 2); thymus: 5.1 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173818,ENDOV,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.0385% (minimum 75%, Missing); amygdala: 69.3694% (minimum 75%, Missing); basal ganglia: 64.1667% (minimum 75%, Missing); cerebellum: 66.9565% (minimum 75%, Missing); cerebral cortex: 65.6250% (minimum 75%, Missing); choroid plexus: 72.4138% (minimum 75%, Missing); colon: 68.5460% (minimum 70%, Missing); hippocampal formation: 69.3694% (minimum 75%, Missing); hypothalamus: 68.7500% (minimum 75%, Missing); kidney: 60.3133% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 71.0769% (minimum 75%, Missing); midbrain: 73.8019% (minimum 75%, Missing); pancreas: 69.3694% (minimum 75%, Missing); pituitary gland: 71.9626% (minimum 75%, Missing); retina: 47.5309% (minimum 75%, Missing); salivary gland: 69.5783% (minimum 70%, Missing); skeletal muscle: 65.4391% (minimum 75%, Missing); skin: 61.4362% (minimum 65%, Missing); small intestine: 72.1875% (minimum 75%, Missing); spinal cord: 71.2963% (minimum 75%, Missing); spleen: 63.8122% (minimum 65%, Missing)",-0.0356383,-0.0145401,-0.274691,0,80,unavailable,25.5,10.6,14.5,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); skin: 14.5 nTPM (manageable, limit 5); spleen: 13.1 nTPM (manageable, limit 5); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 3); hypothalamus: 10.5 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); stomach: 9.2 nTPM (protected, limit 3); pituitary gland: 9 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); small intestine: 8.9 nTPM (vital, limit 1); thyroid gland: 8.9 nTPM (manageable, limit 5); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 3); tongue: 5.3 nTPM (protected, limit 3); lymph node: 5.1 nTPM (protected, limit 3); thymus: 5.1 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173818,ENDOV,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.0385% (minimum 75%, Missing); amygdala: 69.3694% (minimum 75%, Missing); basal ganglia: 64.1667% (minimum 75%, Missing); cerebellum: 66.9565% (minimum 75%, Missing); cerebral cortex: 65.6250% (minimum 75%, Missing); choroid plexus: 72.4138% (minimum 75%, Missing); colon: 68.5460% (minimum 70%, Missing); hippocampal formation: 69.3694% (minimum 75%, Missing); hypothalamus: 68.7500% (minimum 75%, Missing); kidney: 60.3133% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 71.0769% (minimum 75%, Missing); midbrain: 73.8019% (minimum 75%, Missing); pancreas: 69.3694% (minimum 75%, Missing); pituitary gland: 71.9626% (minimum 75%, Missing); retina: 47.5309% (minimum 75%, Missing); salivary gland: 69.5783% (minimum 70%, Missing); skeletal muscle: 65.4391% (minimum 75%, Missing); skin: 61.4362% (minimum 65%, Missing); small intestine: 72.1875% (minimum 75%, Missing); spinal cord: 71.2963% (minimum 75%, Missing); spleen: 63.8122% (minimum 65%, Missing)",-0.0356383,-0.0145401,-0.274691,0,80,unavailable,25.5,10.6,14.5,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); skin: 14.5 nTPM (manageable, limit 5); spleen: 13.1 nTPM (manageable, limit 5); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 3); hypothalamus: 10.5 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); stomach: 9.2 nTPM (protected, limit 3); pituitary gland: 9 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); small intestine: 8.9 nTPM (vital, limit 1); thyroid gland: 8.9 nTPM (manageable, limit 5); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 3); tongue: 5.3 nTPM (protected, limit 3); lymph node: 5.1 nTPM (protected, limit 3); thymus: 5.1 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173818,ENDOV,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.0385% (minimum 75%, Baseline (adaptation disabled)); amygdala: 69.3694% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.1667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 66.9565% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.6250% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.4138% (minimum 75%, Baseline (adaptation disabled)); colon: 68.5460% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 69.3694% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.7500% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.3133% (minimum 75%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 75%, Baseline (adaptation disabled)); lung: 71.0769% (minimum 75%, Baseline (adaptation disabled)); midbrain: 73.8019% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.3694% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 71.9626% (minimum 75%, Baseline (adaptation disabled)); retina: 47.5309% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 69.5783% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 65.4391% (minimum 75%, Baseline (adaptation disabled)); skin: 61.4362% (minimum 65%, Baseline (adaptation disabled)); small intestine: 72.1875% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.2963% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.8122% (minimum 65%, Baseline (adaptation disabled))",-0.0356383,-0.0145401,-0.274691,0,80,unavailable,25.5,10.6,14.5,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); skin: 14.5 nTPM (manageable, limit 5); spleen: 13.1 nTPM (manageable, limit 5); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 3); hypothalamus: 10.5 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); stomach: 9.2 nTPM (protected, limit 3); pituitary gland: 9 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); small intestine: 8.9 nTPM (vital, limit 1); thyroid gland: 8.9 nTPM (manageable, limit 5); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 3); tongue: 5.3 nTPM (protected, limit 3); lymph node: 5.1 nTPM (protected, limit 3); thymus: 5.1 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173818,ENDOV,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.5262% (minimum 99%, Missing); basal ganglia: 97.0247% (minimum 99%, Missing); choroid plexus: 88.2508% (minimum 99%, Missing); hippocampal formation: 97.9487% (minimum 99%, Missing); hypothalamus: 97.8770% (minimum 99%, Missing); pituitary gland: 91.5753% (minimum 99%, Missing)",0.0485063,0.03,-0.107492,0,1,partial,17.8,1,0.2,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173838,MARCHF10,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348506,0.3,0.132508,0,1,partial,17.8,1,0.2,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173838,MARCHF10,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348506,0.3,0.132508,0,1,partial,17.8,1,0.2,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173838,MARCHF10,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348506,0.3,0.132508,0,1,partial,17.8,1,0.2,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173838,MARCHF10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348506,0.292576,0.132508,0,1,partial,17.8,1,0.2,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173838,MARCHF10,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.7179% (minimum 99%, Missing); amygdala: 98.9130% (minimum 99%, Missing); basal ganglia: 98.8154% (minimum 99%, Missing); bone marrow: 84.2593% (minimum 99%, Missing); cerebral cortex: 96.3426% (minimum 99%, Missing); duodenum: 97.2789% (minimum 99%, Missing); heart muscle: 98.3301% (minimum 99%, Missing); hippocampal formation: 98.1373% (minimum 99%, Missing); hypothalamus: 98.7179% (minimum 99%, Missing); kidney: 98.7179% (minimum 99%, Missing); lung: 97.7539% (minimum 99%, Missing); midbrain: 97.5634% (minimum 99%, Missing); pancreas: 98.8154% (minimum 99%, Missing); skeletal muscle: 96.8085% (minimum 99%, Missing); small intestine: 97.1845% (minimum 99%, Missing); spinal cord: 98.7179% (minimum 99%, Missing); spleen: 87.8841% (minimum 95%, Missing); tongue: 96.9961% (minimum 97%, Missing)",-0.0711589,-3.87597e-05,-0.147407,0,80,unavailable,18.7,3.1,13.8,"bone marrow: 18.7 nTPM (vital, limit 1); spleen: 13.8 nTPM (manageable, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173868,PHOSPHO1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.228841,0.269961,0.0925926,0,80,unavailable,18.7,3.1,13.8,"bone marrow: 18.7 nTPM (vital, limit 1); spleen: 13.8 nTPM (manageable, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173868,PHOSPHO1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.228841,0.269961,0.0925926,0,80,unavailable,18.7,3.1,13.8,"bone marrow: 18.7 nTPM (vital, limit 1); spleen: 13.8 nTPM (manageable, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173868,PHOSPHO1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.228841,0.269961,0.0925926,0,80,unavailable,18.7,3.1,13.8,"bone marrow: 18.7 nTPM (vital, limit 1); spleen: 13.8 nTPM (manageable, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173868,PHOSPHO1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.228841,0.269961,0.0925926,0,80,unavailable,18.7,3.1,13.8,"bone marrow: 18.7 nTPM (vital, limit 1); spleen: 13.8 nTPM (manageable, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173868,PHOSPHO1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4879% (minimum 95%, Missing); adrenal gland: 62.3037% (minimum 99%, Missing); amygdala: 80.9524% (minimum 99%, Missing); basal ganglia: 79.3333% (minimum 99%, Missing); bone marrow: 19.1318% (minimum 99%, Missing); cerebellum: 70.0000% (minimum 99%, Missing); cerebral cortex: 67.2316% (minimum 99%, Missing); choroid plexus: 70.8333% (minimum 99%, Missing); colon: 54.0909% (minimum 97%, Missing); duodenum: 52.1930% (minimum 99%, Missing); esophagus: 49.7908% (minimum 97%, Missing); heart muscle: 60.4061% (minimum 99%, Missing); hippocampal formation: 79.8658% (minimum 99%, Missing); hypothalamus: 80.4054% (minimum 99%, Missing); kidney: 55.8685% (minimum 99%, Missing); liver: 58.6207% (minimum 99%, Missing); lung: 55.8685% (minimum 99%, Missing); lymph node: 40.3390% (minimum 97%, Missing); midbrain: 80.4054% (minimum 99%, Missing); pancreas: 52.1930% (minimum 99%, Missing); parathyroid gland: 44.9057% (minimum 97%, Missing); pituitary gland: 69.1860% (minimum 99%, Missing); rectum: 52.1930% (minimum 97%, Missing); retina: 22.6236% (minimum 99%, Missing); salivary gland: 58.0488% (minimum 97%, Missing); skeletal muscle: 58.6207% (minimum 99%, Missing); skin: 58.9109% (minimum 95%, Missing); small intestine: 49.7908% (minimum 99%, Missing); smooth muscle: 47.9839% (minimum 99%, Missing); spinal cord: 74.8428% (minimum 99%, Missing); spleen: 46.6667% (minimum 95%, Missing); stomach: 50.8547% (minimum 97%, Missing); thymus: 42.1986% (minimum 95%, Missing); thyroid gland: 42.5000% (minimum 95%, Missing); tongue: 47.0356% (minimum 97%, Missing); urinary bladder: 51.0730% (minimum 97%, Missing)",-0.528014,-0.56661,-0.798682,0,4,partial,50.3,17.6,16.3,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 2); thymus: 16.3 nTPM (manageable, limit 5); thyroid gland: 16.1 nTPM (manageable, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 2); spleen: 13.6 nTPM (manageable, limit 5); tongue: 13.4 nTPM (protected, limit 2); smooth muscle: 12.9 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); urinary bladder: 11.4 nTPM (protected, limit 2); pancreas: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 2); duodenum: 10.9 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 2); kidney: 9.4 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); salivary gland: 8.6 nTPM (protected, limit 2); liver: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173889,PHC3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4879% (minimum 65%, Missing); adrenal gland: 62.3037% (minimum 75%, Missing); bone marrow: 19.1318% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 67.2316% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); colon: 54.0909% (minimum 70%, Missing); duodenum: 52.1930% (minimum 75%, Missing); esophagus: 49.7908% (minimum 70%, Missing); heart muscle: 60.4061% (minimum 75%, Missing); kidney: 55.8685% (minimum 75%, Missing); liver: 58.6207% (minimum 75%, Missing); lung: 55.8685% (minimum 75%, Missing); lymph node: 40.3390% (minimum 70%, Missing); pancreas: 52.1930% (minimum 75%, Missing); parathyroid gland: 44.9057% (minimum 70%, Missing); pituitary gland: 69.1860% (minimum 75%, Missing); rectum: 52.1930% (minimum 70%, Missing); retina: 22.6236% (minimum 75%, Missing); salivary gland: 58.0488% (minimum 70%, Missing); skeletal muscle: 58.6207% (minimum 75%, Missing); skin: 58.9109% (minimum 65%, Missing); small intestine: 49.7908% (minimum 75%, Missing); smooth muscle: 47.9839% (minimum 75%, Missing); spinal cord: 74.8428% (minimum 75%, Missing); spleen: 46.6667% (minimum 65%, Missing); stomach: 50.8547% (minimum 70%, Missing); thymus: 42.1986% (minimum 65%, Missing); thyroid gland: 42.5000% (minimum 65%, Missing); tongue: 47.0356% (minimum 70%, Missing); urinary bladder: 51.0730% (minimum 70%, Missing)",-0.228014,-0.29661,-0.558682,0,4,partial,50.3,17.6,16.3,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 2); thymus: 16.3 nTPM (manageable, limit 5); thyroid gland: 16.1 nTPM (manageable, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 2); spleen: 13.6 nTPM (manageable, limit 5); tongue: 13.4 nTPM (protected, limit 2); smooth muscle: 12.9 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); urinary bladder: 11.4 nTPM (protected, limit 2); pancreas: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 2); duodenum: 10.9 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 2); kidney: 9.4 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); salivary gland: 8.6 nTPM (protected, limit 2); liver: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173889,PHC3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4879% (minimum 65%, Missing); adrenal gland: 62.3037% (minimum 75%, Missing); bone marrow: 19.1318% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 67.2316% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); colon: 54.0909% (minimum 70%, Missing); duodenum: 52.1930% (minimum 75%, Missing); esophagus: 49.7908% (minimum 70%, Missing); heart muscle: 60.4061% (minimum 75%, Missing); kidney: 55.8685% (minimum 75%, Missing); liver: 58.6207% (minimum 75%, Missing); lung: 55.8685% (minimum 75%, Missing); lymph node: 40.3390% (minimum 70%, Missing); pancreas: 52.1930% (minimum 75%, Missing); parathyroid gland: 44.9057% (minimum 70%, Missing); pituitary gland: 69.1860% (minimum 75%, Missing); rectum: 52.1930% (minimum 70%, Missing); retina: 22.6236% (minimum 75%, Missing); salivary gland: 58.0488% (minimum 70%, Missing); skeletal muscle: 58.6207% (minimum 75%, Missing); skin: 58.9109% (minimum 65%, Missing); small intestine: 49.7908% (minimum 75%, Missing); smooth muscle: 47.9839% (minimum 75%, Missing); spinal cord: 74.8428% (minimum 75%, Missing); spleen: 46.6667% (minimum 65%, Missing); stomach: 50.8547% (minimum 70%, Missing); thymus: 42.1986% (minimum 65%, Missing); thyroid gland: 42.5000% (minimum 65%, Missing); tongue: 47.0356% (minimum 70%, Missing); urinary bladder: 51.0730% (minimum 70%, Missing)",-0.228014,-0.29661,-0.558682,0,4,partial,50.3,17.6,16.3,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 3); thymus: 16.3 nTPM (manageable, limit 5); thyroid gland: 16.1 nTPM (manageable, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 3); spleen: 13.6 nTPM (manageable, limit 5); tongue: 13.4 nTPM (protected, limit 3); smooth muscle: 12.9 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 3); stomach: 11.5 nTPM (protected, limit 3); urinary bladder: 11.4 nTPM (protected, limit 3); pancreas: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 3); duodenum: 10.9 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 3); kidney: 9.4 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); salivary gland: 8.6 nTPM (protected, limit 3); liver: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173889,PHC3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4879% (minimum 65%, Missing); adrenal gland: 62.3037% (minimum 75%, Missing); bone marrow: 19.1318% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 67.2316% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); colon: 54.0909% (minimum 70%, Missing); duodenum: 52.1930% (minimum 75%, Missing); esophagus: 49.7908% (minimum 70%, Missing); heart muscle: 60.4061% (minimum 75%, Missing); kidney: 55.8685% (minimum 75%, Missing); liver: 58.6207% (minimum 75%, Missing); lung: 55.8685% (minimum 75%, Missing); lymph node: 40.3390% (minimum 70%, Missing); pancreas: 52.1930% (minimum 75%, Missing); parathyroid gland: 44.9057% (minimum 70%, Missing); pituitary gland: 69.1860% (minimum 75%, Missing); rectum: 52.1930% (minimum 70%, Missing); retina: 22.6236% (minimum 75%, Missing); salivary gland: 58.0488% (minimum 70%, Missing); skeletal muscle: 58.6207% (minimum 75%, Missing); skin: 58.9109% (minimum 65%, Missing); small intestine: 49.7908% (minimum 75%, Missing); smooth muscle: 47.9839% (minimum 75%, Missing); spinal cord: 74.8428% (minimum 75%, Missing); spleen: 46.6667% (minimum 65%, Missing); stomach: 50.8547% (minimum 70%, Missing); thymus: 42.1986% (minimum 65%, Missing); thyroid gland: 42.5000% (minimum 65%, Missing); tongue: 47.0356% (minimum 70%, Missing); urinary bladder: 51.0730% (minimum 70%, Missing)",-0.228014,-0.29661,-0.558682,0,4,partial,50.3,17.6,16.3,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 3); thymus: 16.3 nTPM (manageable, limit 5); thyroid gland: 16.1 nTPM (manageable, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 3); spleen: 13.6 nTPM (manageable, limit 5); tongue: 13.4 nTPM (protected, limit 3); smooth muscle: 12.9 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 3); stomach: 11.5 nTPM (protected, limit 3); urinary bladder: 11.4 nTPM (protected, limit 3); pancreas: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 3); duodenum: 10.9 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 3); kidney: 9.4 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); salivary gland: 8.6 nTPM (protected, limit 3); liver: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173889,PHC3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4879% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.3037% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 19.1318% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 67.2316% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.8333% (minimum 75%, Baseline (adaptation disabled)); colon: 54.0909% (minimum 70%, Baseline (adaptation disabled)); duodenum: 52.1930% (minimum 75%, Baseline (adaptation disabled)); esophagus: 49.7908% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.4061% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.8685% (minimum 75%, Baseline (adaptation disabled)); liver: 58.6207% (minimum 75%, Baseline (adaptation disabled)); lung: 55.8685% (minimum 75%, Baseline (adaptation disabled)); lymph node: 40.3390% (minimum 70%, Baseline (adaptation disabled)); pancreas: 52.1930% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 44.9057% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.1860% (minimum 75%, Baseline (adaptation disabled)); rectum: 52.1930% (minimum 70%, Baseline (adaptation disabled)); retina: 22.6236% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.0488% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 58.6207% (minimum 75%, Baseline (adaptation disabled)); skin: 58.9109% (minimum 65%, Baseline (adaptation disabled)); small intestine: 49.7908% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 47.9839% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.8428% (minimum 75%, Baseline (adaptation disabled)); spleen: 46.6667% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.8547% (minimum 70%, Baseline (adaptation disabled)); thymus: 42.1986% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 42.5000% (minimum 65%, Baseline (adaptation disabled)); tongue: 47.0356% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.0730% (minimum 70%, Baseline (adaptation disabled))",-0.228014,-0.29661,-0.558682,0,4,partial,50.3,17.6,16.3,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 3); thymus: 16.3 nTPM (manageable, limit 5); thyroid gland: 16.1 nTPM (manageable, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 3); spleen: 13.6 nTPM (manageable, limit 5); tongue: 13.4 nTPM (protected, limit 3); smooth muscle: 12.9 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 3); stomach: 11.5 nTPM (protected, limit 3); urinary bladder: 11.4 nTPM (protected, limit 3); pancreas: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 3); duodenum: 10.9 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 3); kidney: 9.4 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); salivary gland: 8.6 nTPM (protected, limit 3); liver: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173889,PHC3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.9281% (minimum 90%, Approved); adrenal gland: 97.6562% (minimum 98%, Approved); amygdala: 97.6562% (minimum 99%, Missing); basal ganglia: 96.1538% (minimum 99%, Missing); bone marrow: 85.0340% (minimum 99%, Missing); cerebral cortex: 94.6970% (minimum 98%, Approved); choroid plexus: 98.4252% (minimum 99%, Missing); colon: 96.1538% (minimum 97%, Missing); duodenum: 97.6562% (minimum 99%, Missing); esophagus: 75.3012% (minimum 97%, Missing); heart muscle: 85.0340% (minimum 98%, Approved); hippocampal formation: 96.8992% (minimum 99%, Missing); hypothalamus: 97.6562% (minimum 99%, Missing); kidney: 88.6525% (minimum 98%, Approved); liver: 96.8992% (minimum 98%, Approved); lung: 91.2409% (minimum 99%, Missing); lymph node: 90.5797% (minimum 97%, Missing); midbrain: 96.8992% (minimum 99%, Missing); pancreas: 90.5797% (minimum 98%, Approved); parathyroid gland: 96.1538% (minimum 97%, Missing); pituitary gland: 98.4252% (minimum 99%, Missing); retina: 96.8992% (minimum 99%, Missing); salivary gland: 93.9850% (minimum 95%, Approved); skeletal muscle: 94.6970% (minimum 98%, Approved); skin: 86.2069% (minimum 95%, Missing); small intestine: 95.4198% (minimum 99%, Missing); smooth muscle: 95.4198% (minimum 98%, Approved); spinal cord: 96.8992% (minimum 99%, Missing); spleen: 88.6525% (minimum 95%, Missing); stomach: 96.1538% (minimum 97%, Missing); thymus: 63.4518% (minimum 95%, Missing); tongue: 91.9118% (minimum 97%, Missing); urinary bladder: 93.2836% (minimum 97%, Missing)",-0.315482,-0.216988,-0.13966,0,1,partial,2.2,4.1,7.2,"thymus: 7.2 nTPM (manageable, limit 5); esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 2); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173894,CBX2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"thymus: 63.4518% (minimum 65%, Missing)",-0.0154822,0.053012,0.10034,0,1,partial,2.2,4.1,7.2,"thymus: 7.2 nTPM (manageable, limit 5); esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 2); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173894,CBX2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"thymus: 63.4518% (minimum 65%, Missing)",-0.0154822,0.053012,0.10034,0,1,partial,2.2,4.1,7.2,"thymus: 7.2 nTPM (manageable, limit 5); esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 2); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173894,CBX2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"thymus: 63.4518% (minimum 65%, Missing)",-0.0154822,0.053012,0.10034,0,1,partial,2.2,4.1,7.2,"thymus: 7.2 nTPM (manageable, limit 5); esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 2); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173894,CBX2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"thymus: 63.4518% (minimum 65%, Baseline (adaptation disabled))",-0.0154822,0.053012,0.10034,0,1,partial,2.2,4.1,7.2,"thymus: 7.2 nTPM (manageable, limit 5); esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173894,CBX2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 5.8333% (minimum 95%, Missing)",-0.891667,0.03,0.01,0,5,partial,0,0,11.3,"skin: 11.3 nTPM (manageable, limit 5)",,68,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173908,KRT28,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 5.8333% (minimum 65%, Missing)",-0.591667,0.3,0.25,0,5,partial,0,0,11.3,"skin: 11.3 nTPM (manageable, limit 5)",,68,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173908,KRT28,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 5.8333% (minimum 65%, Missing)",-0.591667,0.3,0.25,0,5,partial,0,0,11.3,"skin: 11.3 nTPM (manageable, limit 5)",,68,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173908,KRT28,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 5.8333% (minimum 65%, Missing)",-0.591667,0.3,0.25,0,5,partial,0,0,11.3,"skin: 11.3 nTPM (manageable, limit 5)",,68,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173908,KRT28,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 5.8333% (minimum 65%, Baseline (adaptation disabled))",-0.591667,0.3,0.25,0,5,partial,0,0,11.3,"skin: 11.3 nTPM (manageable, limit 5)",,68,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173908,KRT28,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.7436% (minimum 95%, Missing); adrenal gland: 81.3953% (minimum 99%, Missing); amygdala: 97.2222% (minimum 99%, Missing); bone marrow: 29.1667% (minimum 99%, Missing); cerebral cortex: 92.1053% (minimum 99%, Missing); colon: 77.7778% (minimum 97%, Missing); duodenum: 62.5000% (minimum 99%, Missing); heart muscle: 92.1053% (minimum 99%, Missing); hippocampal formation: 97.2222% (minimum 99%, Missing); hypothalamus: 97.2222% (minimum 99%, Missing); kidney: 8.0275% (minimum 99%, Missing); liver: 32.4074% (minimum 99%, Missing); lung: 31.5315% (minimum 99%, Missing); lymph node: 87.5000% (minimum 97%, Missing); pancreas: 89.7436% (minimum 99%, Missing); pituitary gland: 94.5946% (minimum 99%, Missing); rectum: 81.3953% (minimum 97%, Missing); retina: 97.2222% (minimum 99%, Missing); salivary gland: 64.8148% (minimum 97%, Missing); skeletal muscle: 97.2222% (minimum 99%, Missing); skin: 92.1053% (minimum 95%, Missing); small intestine: 70.0000% (minimum 99%, Missing); smooth muscle: 97.2222% (minimum 99%, Missing); spleen: 72.9167% (minimum 95%, Missing); stomach: 85.3659% (minimum 97%, Missing); thymus: 79.5455% (minimum 95%, Missing); thyroid gland: 68.6275% (minimum 95%, Missing); urinary bladder: 94.5946% (minimum 97%, Missing)",-0.263725,-0.321852,-0.909725,0,80,unavailable,40.1,1.9,1.6,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173930,SLCO4C1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 29.1667% (minimum 75%, Missing); duodenum: 62.5000% (minimum 75%, Missing); kidney: 8.0275% (minimum 75%, Missing); liver: 32.4074% (minimum 75%, Missing); lung: 31.5315% (minimum 75%, Missing); salivary gland: 64.8148% (minimum 70%, Missing); small intestine: 70.0000% (minimum 75%, Missing)",0.0362745,-0.0518519,-0.669725,0,80,unavailable,40.1,1.9,1.6,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173930,SLCO4C1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 29.1667% (minimum 75%, Missing); duodenum: 62.5000% (minimum 75%, Missing); kidney: 8.0275% (minimum 75%, Missing); liver: 32.4074% (minimum 75%, Missing); lung: 31.5315% (minimum 75%, Missing); salivary gland: 64.8148% (minimum 70%, Missing); small intestine: 70.0000% (minimum 75%, Missing)",0.0362745,-0.0518519,-0.669725,0,80,unavailable,40.1,1.9,1.6,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173930,SLCO4C1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 29.1667% (minimum 75%, Missing); duodenum: 62.5000% (minimum 75%, Missing); kidney: 8.0275% (minimum 75%, Missing); liver: 32.4074% (minimum 75%, Missing); lung: 31.5315% (minimum 75%, Missing); salivary gland: 64.8148% (minimum 70%, Missing); small intestine: 70.0000% (minimum 75%, Missing)",0.0362745,-0.0518519,-0.669725,0,80,unavailable,40.1,1.9,1.6,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173930,SLCO4C1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 29.1667% (minimum 75%, Baseline (adaptation disabled)); duodenum: 62.5000% (minimum 75%, Baseline (adaptation disabled)); kidney: 8.0275% (minimum 75%, Baseline (adaptation disabled)); liver: 32.4074% (minimum 75%, Baseline (adaptation disabled)); lung: 31.5315% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.8148% (minimum 70%, Baseline (adaptation disabled)); small intestine: 70.0000% (minimum 75%, Baseline (adaptation disabled))",0.0362745,-0.0518519,-0.669725,0,80,unavailable,40.1,1.9,1.6,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173930,SLCO4C1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6604% (minimum 95%, Missing); adrenal gland: 48.1517% (minimum 99%, Missing); amygdala: 62.5702% (minimum 99%, Missing); basal ganglia: 62.2595% (minimum 99%, Missing); bone marrow: 43.6466% (minimum 99%, Missing); cerebellum: 47.6711% (minimum 99%, Missing); cerebral cortex: 62.7660% (minimum 99%, Missing); choroid plexus: 58.0776% (minimum 99%, Missing); colon: 51.9151% (minimum 97%, Missing); duodenum: 60.4217% (minimum 99%, Missing); esophagus: 50.7078% (minimum 97%, Missing); heart muscle: 57.8098% (minimum 99%, Missing); hippocampal formation: 63.4008% (minimum 99%, Missing); hypothalamus: 61.8754% (minimum 99%, Missing); kidney: 46.3066% (minimum 99%, Missing); liver: 55.5371% (minimum 99%, Missing); lung: 57.2162% (minimum 99%, Missing); lymph node: 51.3043% (minimum 97%, Missing); midbrain: 64.1715% (minimum 99%, Missing); pancreas: 47.2000% (minimum 99%, Missing); parathyroid gland: 57.3471% (minimum 97%, Missing); pituitary gland: 54.4813% (minimum 99%, Missing); rectum: 62.3756% (minimum 97%, Missing); retina: 58.3140% (minimum 99%, Missing); salivary gland: 53.6938% (minimum 97%, Missing); skeletal muscle: 51.8346% (minimum 99%, Missing); skin: 56.1276% (minimum 95%, Missing); small intestine: 55.2313% (minimum 99%, Missing); smooth muscle: 60.2041% (minimum 99%, Missing); spinal cord: 64.1715% (minimum 99%, Missing); spleen: 49.5064% (minimum 95%, Missing); stomach: 51.2257% (minimum 97%, Missing); thymus: 48.4307% (minimum 95%, Missing); thyroid gland: 54.6892% (minimum 95%, Missing); tongue: 59.0695% (minimum 97%, Missing); urinary bladder: 55.1705% (minimum 97%, Missing)",-0.465693,-0.462922,-0.553534,0,0,routine_complete,129.5,97.5,106.8,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); thymus: 106.8 nTPM (manageable, limit 5); spleen: 102.3 nTPM (manageable, limit 5); esophagus: 97.5 nTPM (protected, limit 2); stomach: 95.5 nTPM (protected, limit 2); lymph node: 95.2 nTPM (protected, limit 2); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 2); salivary gland: 86.5 nTPM (protected, limit 2); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (manageable, limit 5); urinary bladder: 81.5 nTPM (protected, limit 2); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (manageable, limit 5); skin: 78.4 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 2); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 2); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 2); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); spinal cord: 56 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173933,RBM4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6604% (minimum 65%, Missing); adrenal gland: 48.1517% (minimum 75%, Missing); amygdala: 62.5702% (minimum 75%, Missing); basal ganglia: 62.2595% (minimum 75%, Missing); bone marrow: 43.6466% (minimum 75%, Missing); cerebellum: 47.6711% (minimum 75%, Missing); cerebral cortex: 62.7660% (minimum 75%, Missing); choroid plexus: 58.0776% (minimum 75%, Missing); colon: 51.9151% (minimum 70%, Missing); duodenum: 60.4217% (minimum 75%, Missing); esophagus: 50.7078% (minimum 70%, Missing); heart muscle: 57.8098% (minimum 75%, Missing); hippocampal formation: 63.4008% (minimum 75%, Missing); hypothalamus: 61.8754% (minimum 75%, Missing); kidney: 46.3066% (minimum 75%, Missing); liver: 55.5371% (minimum 75%, Missing); lung: 57.2162% (minimum 75%, Missing); lymph node: 51.3043% (minimum 70%, Missing); midbrain: 64.1715% (minimum 75%, Missing); pancreas: 47.2000% (minimum 75%, Missing); parathyroid gland: 57.3471% (minimum 70%, Missing); pituitary gland: 54.4813% (minimum 75%, Missing); rectum: 62.3756% (minimum 70%, Missing); retina: 58.3140% (minimum 75%, Missing); salivary gland: 53.6938% (minimum 70%, Missing); skeletal muscle: 51.8346% (minimum 75%, Missing); skin: 56.1276% (minimum 65%, Missing); small intestine: 55.2313% (minimum 75%, Missing); smooth muscle: 60.2041% (minimum 75%, Missing); spinal cord: 64.1715% (minimum 75%, Missing); spleen: 49.5064% (minimum 65%, Missing); stomach: 51.2257% (minimum 70%, Missing); thymus: 48.4307% (minimum 65%, Missing); thyroid gland: 54.6892% (minimum 65%, Missing); tongue: 59.0695% (minimum 70%, Missing); urinary bladder: 55.1705% (minimum 70%, Missing)",-0.165693,-0.192922,-0.313534,0,0,routine_complete,129.5,97.5,106.8,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); thymus: 106.8 nTPM (manageable, limit 5); spleen: 102.3 nTPM (manageable, limit 5); esophagus: 97.5 nTPM (protected, limit 2); stomach: 95.5 nTPM (protected, limit 2); lymph node: 95.2 nTPM (protected, limit 2); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 2); salivary gland: 86.5 nTPM (protected, limit 2); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (manageable, limit 5); urinary bladder: 81.5 nTPM (protected, limit 2); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (manageable, limit 5); skin: 78.4 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 2); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 2); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 2); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); spinal cord: 56 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173933,RBM4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6604% (minimum 65%, Missing); adrenal gland: 48.1517% (minimum 75%, Missing); amygdala: 62.5702% (minimum 75%, Missing); basal ganglia: 62.2595% (minimum 75%, Missing); bone marrow: 43.6466% (minimum 75%, Missing); cerebellum: 47.6711% (minimum 75%, Missing); cerebral cortex: 62.7660% (minimum 75%, Missing); choroid plexus: 58.0776% (minimum 75%, Missing); colon: 51.9151% (minimum 70%, Missing); duodenum: 60.4217% (minimum 75%, Missing); esophagus: 50.7078% (minimum 70%, Missing); heart muscle: 57.8098% (minimum 75%, Missing); hippocampal formation: 63.4008% (minimum 75%, Missing); hypothalamus: 61.8754% (minimum 75%, Missing); kidney: 46.3066% (minimum 75%, Missing); liver: 55.5371% (minimum 75%, Missing); lung: 57.2162% (minimum 75%, Missing); lymph node: 51.3043% (minimum 70%, Missing); midbrain: 64.1715% (minimum 75%, Missing); pancreas: 47.2000% (minimum 75%, Missing); parathyroid gland: 57.3471% (minimum 70%, Missing); pituitary gland: 54.4813% (minimum 75%, Missing); rectum: 62.3756% (minimum 70%, Missing); retina: 58.3140% (minimum 75%, Missing); salivary gland: 53.6938% (minimum 70%, Missing); skeletal muscle: 51.8346% (minimum 75%, Missing); skin: 56.1276% (minimum 65%, Missing); small intestine: 55.2313% (minimum 75%, Missing); smooth muscle: 60.2041% (minimum 75%, Missing); spinal cord: 64.1715% (minimum 75%, Missing); spleen: 49.5064% (minimum 65%, Missing); stomach: 51.2257% (minimum 70%, Missing); thymus: 48.4307% (minimum 65%, Missing); thyroid gland: 54.6892% (minimum 65%, Missing); tongue: 59.0695% (minimum 70%, Missing); urinary bladder: 55.1705% (minimum 70%, Missing)",-0.165693,-0.192922,-0.313534,0,0,routine_complete,129.5,97.5,106.8,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); thymus: 106.8 nTPM (manageable, limit 5); spleen: 102.3 nTPM (manageable, limit 5); esophagus: 97.5 nTPM (protected, limit 3); stomach: 95.5 nTPM (protected, limit 3); lymph node: 95.2 nTPM (protected, limit 3); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 3); salivary gland: 86.5 nTPM (protected, limit 3); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (manageable, limit 5); urinary bladder: 81.5 nTPM (protected, limit 3); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (manageable, limit 5); skin: 78.4 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 3); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 3); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 3); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); spinal cord: 56 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173933,RBM4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6604% (minimum 65%, Missing); adrenal gland: 48.1517% (minimum 75%, Missing); amygdala: 62.5702% (minimum 75%, Missing); basal ganglia: 62.2595% (minimum 75%, Missing); bone marrow: 43.6466% (minimum 75%, Missing); cerebellum: 47.6711% (minimum 75%, Missing); cerebral cortex: 62.7660% (minimum 75%, Missing); choroid plexus: 58.0776% (minimum 75%, Missing); colon: 51.9151% (minimum 70%, Missing); duodenum: 60.4217% (minimum 75%, Missing); esophagus: 50.7078% (minimum 70%, Missing); heart muscle: 57.8098% (minimum 75%, Missing); hippocampal formation: 63.4008% (minimum 75%, Missing); hypothalamus: 61.8754% (minimum 75%, Missing); kidney: 46.3066% (minimum 75%, Missing); liver: 55.5371% (minimum 75%, Missing); lung: 57.2162% (minimum 75%, Missing); lymph node: 51.3043% (minimum 70%, Missing); midbrain: 64.1715% (minimum 75%, Missing); pancreas: 47.2000% (minimum 75%, Missing); parathyroid gland: 57.3471% (minimum 70%, Missing); pituitary gland: 54.4813% (minimum 75%, Missing); rectum: 62.3756% (minimum 70%, Missing); retina: 58.3140% (minimum 75%, Missing); salivary gland: 53.6938% (minimum 70%, Missing); skeletal muscle: 51.8346% (minimum 75%, Missing); skin: 56.1276% (minimum 65%, Missing); small intestine: 55.2313% (minimum 75%, Missing); smooth muscle: 60.2041% (minimum 75%, Missing); spinal cord: 64.1715% (minimum 75%, Missing); spleen: 49.5064% (minimum 65%, Missing); stomach: 51.2257% (minimum 70%, Missing); thymus: 48.4307% (minimum 65%, Missing); thyroid gland: 54.6892% (minimum 65%, Missing); tongue: 59.0695% (minimum 70%, Missing); urinary bladder: 55.1705% (minimum 70%, Missing)",-0.165693,-0.192922,-0.313534,0,0,routine_complete,129.5,97.5,106.8,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); thymus: 106.8 nTPM (manageable, limit 5); spleen: 102.3 nTPM (manageable, limit 5); esophagus: 97.5 nTPM (protected, limit 3); stomach: 95.5 nTPM (protected, limit 3); lymph node: 95.2 nTPM (protected, limit 3); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 3); salivary gland: 86.5 nTPM (protected, limit 3); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (manageable, limit 5); urinary bladder: 81.5 nTPM (protected, limit 3); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (manageable, limit 5); skin: 78.4 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 3); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 3); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 3); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); spinal cord: 56 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173933,RBM4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6604% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 48.1517% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.5702% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.2595% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 43.6466% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 47.6711% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.7660% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.0776% (minimum 75%, Baseline (adaptation disabled)); colon: 51.9151% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.4217% (minimum 75%, Baseline (adaptation disabled)); esophagus: 50.7078% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 57.8098% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.4008% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.8754% (minimum 75%, Baseline (adaptation disabled)); kidney: 46.3066% (minimum 75%, Baseline (adaptation disabled)); liver: 55.5371% (minimum 75%, Baseline (adaptation disabled)); lung: 57.2162% (minimum 75%, Baseline (adaptation disabled)); lymph node: 51.3043% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.1715% (minimum 75%, Baseline (adaptation disabled)); pancreas: 47.2000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.3471% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 54.4813% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.3756% (minimum 70%, Baseline (adaptation disabled)); retina: 58.3140% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.6938% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 51.8346% (minimum 75%, Baseline (adaptation disabled)); skin: 56.1276% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.2313% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.2041% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.1715% (minimum 75%, Baseline (adaptation disabled)); spleen: 49.5064% (minimum 65%, Baseline (adaptation disabled)); stomach: 51.2257% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.4307% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.6892% (minimum 65%, Baseline (adaptation disabled)); tongue: 59.0695% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 55.1705% (minimum 70%, Baseline (adaptation disabled))",-0.165693,-0.192922,-0.313534,0,0,routine_complete,129.5,97.5,106.8,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); thymus: 106.8 nTPM (manageable, limit 5); spleen: 102.3 nTPM (manageable, limit 5); esophagus: 97.5 nTPM (protected, limit 3); stomach: 95.5 nTPM (protected, limit 3); lymph node: 95.2 nTPM (protected, limit 3); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 3); salivary gland: 86.5 nTPM (protected, limit 3); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (manageable, limit 5); urinary bladder: 81.5 nTPM (protected, limit 3); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (manageable, limit 5); skin: 78.4 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 3); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 3); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 3); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); spinal cord: 56 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173933,RBM4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.6667% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 91.6667% (minimum 99%, Missing); bone marrow: 89.1892% (minimum 99%, Missing); cerebral cortex: 73.3333% (minimum 99%, Missing); choroid plexus: 94.2857% (minimum 99%, Missing); heart muscle: 97.0588% (minimum 99%, Missing); hippocampal formation: 80.4878% (minimum 99%, Missing); hypothalamus: 86.8421% (minimum 99%, Missing); liver: 97.0588% (minimum 99%, Missing); lung: 89.1892% (minimum 99%, Missing); lymph node: 94.2857% (minimum 97%, Missing); midbrain: 68.7500% (minimum 99%, Missing); retina: 58.9286% (minimum 99%, Missing); salivary gland: 91.6667% (minimum 97%, Missing); smooth muscle: 97.0588% (minimum 99%, Missing); spinal cord: 45.2055% (minimum 99%, Missing); thymus: 73.3333% (minimum 95%, Missing)",-0.216667,-0.0533333,-0.537945,0,80,unavailable,4,0.3,1.2,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173988,LRRC63,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 73.3333% (minimum 75%, Missing); midbrain: 68.7500% (minimum 75%, Missing); retina: 58.9286% (minimum 75%, Missing); spinal cord: 45.2055% (minimum 75%, Missing)",0.0833333,0.216667,-0.297945,0,80,unavailable,4,0.3,1.2,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173988,LRRC63,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 73.3333% (minimum 75%, Missing); midbrain: 68.7500% (minimum 75%, Missing); retina: 58.9286% (minimum 75%, Missing); spinal cord: 45.2055% (minimum 75%, Missing)",0.0833333,0.216667,-0.297945,0,80,unavailable,4,0.3,1.2,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173988,LRRC63,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 73.3333% (minimum 75%, Missing); midbrain: 68.7500% (minimum 75%, Missing); retina: 58.9286% (minimum 75%, Missing); spinal cord: 45.2055% (minimum 75%, Missing)",0.0833333,0.216667,-0.297945,0,80,unavailable,4,0.3,1.2,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173988,LRRC63,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 73.3333% (minimum 75%, Baseline (adaptation disabled)); midbrain: 68.7500% (minimum 75%, Baseline (adaptation disabled)); retina: 58.9286% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 45.2055% (minimum 75%, Baseline (adaptation disabled))",0.0833333,0.216667,-0.297945,0,80,unavailable,4,0.3,1.2,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000173988,LRRC63,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 79.3388% (minimum 95%, Enhanced); amygdala: 67.1329% (minimum 99%, Missing); basal ganglia: 60.7595% (minimum 99%, Missing); bone marrow: 89.7196% (minimum 95%, Enhanced); cerebellum: 72.7273% (minimum 99%, Missing); cerebral cortex: 60.0000% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 87.2727% (minimum 97%, Missing); duodenum: 91.4286% (minimum 99%, Missing); heart muscle: 88.0734% (minimum 95%, Enhanced); hippocampal formation: 67.1329% (minimum 99%, Missing); hypothalamus: 64.4295% (minimum 99%, Missing); kidney: 79.3388% (minimum 95%, Enhanced); liver: 89.7196% (minimum 95%, Enhanced); lung: 85.7143% (minimum 99%, Missing); lymph node: 77.4194% (minimum 80%, Enhanced); midbrain: 71.6418% (minimum 99%, Missing); pancreas: 93.2039% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 80%, Enhanced); pituitary gland: 72.1805% (minimum 99%, Missing); rectum: 91.4286% (minimum 97%, Missing); retina: 60.0000% (minimum 99%, Missing); skeletal muscle: 94.1176% (minimum 95%, Enhanced); small intestine: 89.7196% (minimum 99%, Missing); smooth muscle: 88.0734% (minimum 95%, Enhanced); spinal cord: 79.3388% (minimum 99%, Missing); thymus: 56.4706% (minimum 95%, Missing); tongue: 84.2105% (minimum 97%, Missing)",-0.385294,-0.127895,-0.39,0,5,partial,6.4,3.2,7.4,"thymus: 7.4 nTPM (manageable, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174007,CEP19,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 67.1329% (minimum 75%, Missing); basal ganglia: 60.7595% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); hippocampal formation: 67.1329% (minimum 75%, Missing); hypothalamus: 64.4295% (minimum 75%, Missing); midbrain: 71.6418% (minimum 75%, Missing); pituitary gland: 72.1805% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); thymus: 56.4706% (minimum 65%, Missing)",-0.0852941,0.142105,-0.15,0,5,partial,6.4,3.2,7.4,"thymus: 7.4 nTPM (manageable, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174007,CEP19,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 67.1329% (minimum 75%, Missing); basal ganglia: 60.7595% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); hippocampal formation: 67.1329% (minimum 75%, Missing); hypothalamus: 64.4295% (minimum 75%, Missing); midbrain: 71.6418% (minimum 75%, Missing); pituitary gland: 72.1805% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); thymus: 56.4706% (minimum 65%, Missing)",-0.0852941,0.142105,-0.15,0,5,partial,6.4,3.2,7.4,"thymus: 7.4 nTPM (manageable, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174007,CEP19,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 67.1329% (minimum 75%, Missing); basal ganglia: 60.7595% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); hippocampal formation: 67.1329% (minimum 75%, Missing); hypothalamus: 64.4295% (minimum 75%, Missing); midbrain: 71.6418% (minimum 75%, Missing); pituitary gland: 72.1805% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); thymus: 56.4706% (minimum 65%, Missing)",-0.0852941,0.142105,-0.15,0,5,partial,6.4,3.2,7.4,"thymus: 7.4 nTPM (manageable, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174007,CEP19,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 67.1329% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.7595% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.7273% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.1329% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.4295% (minimum 75%, Baseline (adaptation disabled)); midbrain: 71.6418% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 72.1805% (minimum 75%, Baseline (adaptation disabled)); retina: 60.0000% (minimum 75%, Baseline (adaptation disabled)); thymus: 56.4706% (minimum 65%, Baseline (adaptation disabled))",-0.0852941,0.05,-0.15,0,5,partial,6.4,3.2,7.4,"thymus: 7.4 nTPM (manageable, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174007,CEP19,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0.1,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174015,CBY2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174015,CBY2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174015,CBY2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174015,CBY2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347927,0.298963,0.248963,0,1,partial,0.1,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174015,CBY2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174016,TENT5D,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174016,TENT5D,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174016,TENT5D,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174016,TENT5D,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174016,TENT5D,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.0481% (minimum 99%, Missing); cerebral cortex: 98.0282% (minimum 99%, Missing); heart muscle: 98.8636% (minimum 99%, Missing); liver: 98.0282% (minimum 99%, Missing); retina: 96.1326% (minimum 99%, Missing); skeletal muscle: 96.6667% (minimum 99%, Missing)",0.0193593,0.00752809,-0.0595187,0,80,unavailable,2.6,0.8,1.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174038,SPATA31G1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319359,0.277528,0.180481,0,80,unavailable,2.6,0.8,1.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174038,SPATA31G1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319359,0.277528,0.180481,0,80,unavailable,2.6,0.8,1.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174038,SPATA31G1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319359,0.277528,0.180481,0,80,unavailable,2.6,0.8,1.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174038,SPATA31G1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319359,0.277528,0.180481,0,80,unavailable,2.6,0.8,1.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174038,SPATA31G1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.4321% (minimum 95%, Uncertain); adrenal gland: 56.9892% (minimum 99%, Uncertain); amygdala: 65.4321% (minimum 99%, Missing); basal ganglia: 54.6392% (minimum 99%, Missing); bone marrow: 75.7143% (minimum 99%, Missing); cerebellum: 74.6479% (minimum 99%, Uncertain); cerebral cortex: 58.8889% (minimum 99%, Missing); choroid plexus: 74.6479% (minimum 99%, Missing); colon: 66.2500% (minimum 97%, Missing); duodenum: 63.8554% (minimum 99%, Missing); esophagus: 56.3830% (minimum 97%, Uncertain); heart muscle: 70.6667% (minimum 99%, Uncertain); hippocampal formation: 62.3529% (minimum 99%, Missing); hypothalamus: 64.6341% (minimum 99%, Missing); kidney: 50.0000% (minimum 99%, Missing); liver: 38.9706% (minimum 99%, Uncertain); lung: 66.2500% (minimum 99%, Missing); lymph node: 52.4752% (minimum 97%, Uncertain); midbrain: 61.6279% (minimum 99%, Missing); pancreas: 51.4563% (minimum 99%, Missing); parathyroid gland: 49.0741% (minimum 97%, Uncertain); pituitary gland: 67.9487% (minimum 99%, Missing); rectum: 63.8554% (minimum 97%, Missing); retina: 77.9412% (minimum 99%, Missing); salivary gland: 65.4321% (minimum 97%, Uncertain); skeletal muscle: 55.2083% (minimum 99%, Uncertain); skin: 49.5327% (minimum 95%, Uncertain); small intestine: 68.8312% (minimum 99%, Missing); smooth muscle: 70.6667% (minimum 99%, Uncertain); spinal cord: 59.5506% (minimum 99%, Missing); spleen: 52.4752% (minimum 95%, Uncertain); stomach: 63.8554% (minimum 97%, Missing); thymus: 62.3529% (minimum 95%, Missing); thyroid gland: 49.5327% (minimum 95%, Missing); tongue: 63.0952% (minimum 97%, Missing); urinary bladder: 67.9487% (minimum 97%, Missing)",-0.454673,-0.479259,-0.600294,0,4,partial,8.3,5.5,5.4,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); thyroid gland: 5.4 nTPM (manageable, limit 5); skin: 5.4 nTPM (manageable, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174206,KICS2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 56.9892% (minimum 75%, Uncertain); amygdala: 65.4321% (minimum 75%, Missing); basal ganglia: 54.6392% (minimum 75%, Missing); cerebellum: 74.6479% (minimum 75%, Uncertain); cerebral cortex: 58.8889% (minimum 75%, Missing); choroid plexus: 74.6479% (minimum 75%, Missing); colon: 66.2500% (minimum 70%, Missing); duodenum: 63.8554% (minimum 75%, Missing); esophagus: 56.3830% (minimum 70%, Uncertain); heart muscle: 70.6667% (minimum 75%, Uncertain); hippocampal formation: 62.3529% (minimum 75%, Missing); hypothalamus: 64.6341% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 38.9706% (minimum 75%, Uncertain); lung: 66.2500% (minimum 75%, Missing); lymph node: 52.4752% (minimum 70%, Uncertain); midbrain: 61.6279% (minimum 75%, Missing); pancreas: 51.4563% (minimum 75%, Missing); parathyroid gland: 49.0741% (minimum 70%, Uncertain); pituitary gland: 67.9487% (minimum 75%, Missing); rectum: 63.8554% (minimum 70%, Missing); salivary gland: 65.4321% (minimum 70%, Uncertain); skeletal muscle: 55.2083% (minimum 75%, Uncertain); skin: 49.5327% (minimum 65%, Uncertain); small intestine: 68.8312% (minimum 75%, Missing); smooth muscle: 70.6667% (minimum 75%, Uncertain); spinal cord: 59.5506% (minimum 75%, Missing); spleen: 52.4752% (minimum 65%, Uncertain); stomach: 63.8554% (minimum 70%, Missing); thymus: 62.3529% (minimum 65%, Missing); thyroid gland: 49.5327% (minimum 65%, Missing); tongue: 63.0952% (minimum 70%, Missing); urinary bladder: 67.9487% (minimum 70%, Missing)",-0.154673,-0.209259,-0.360294,0,4,partial,8.3,5.5,5.4,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); thyroid gland: 5.4 nTPM (manageable, limit 5); skin: 5.4 nTPM (manageable, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174206,KICS2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 56.9892% (minimum 75%, Uncertain); amygdala: 65.4321% (minimum 75%, Missing); basal ganglia: 54.6392% (minimum 75%, Missing); cerebellum: 74.6479% (minimum 75%, Uncertain); cerebral cortex: 58.8889% (minimum 75%, Missing); choroid plexus: 74.6479% (minimum 75%, Missing); colon: 66.2500% (minimum 70%, Missing); duodenum: 63.8554% (minimum 75%, Missing); esophagus: 56.3830% (minimum 70%, Uncertain); heart muscle: 70.6667% (minimum 75%, Uncertain); hippocampal formation: 62.3529% (minimum 75%, Missing); hypothalamus: 64.6341% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 38.9706% (minimum 75%, Uncertain); lung: 66.2500% (minimum 75%, Missing); lymph node: 52.4752% (minimum 70%, Uncertain); midbrain: 61.6279% (minimum 75%, Missing); pancreas: 51.4563% (minimum 75%, Missing); parathyroid gland: 49.0741% (minimum 70%, Uncertain); pituitary gland: 67.9487% (minimum 75%, Missing); rectum: 63.8554% (minimum 70%, Missing); salivary gland: 65.4321% (minimum 70%, Uncertain); skeletal muscle: 55.2083% (minimum 75%, Uncertain); skin: 49.5327% (minimum 65%, Uncertain); small intestine: 68.8312% (minimum 75%, Missing); smooth muscle: 70.6667% (minimum 75%, Uncertain); spinal cord: 59.5506% (minimum 75%, Missing); spleen: 52.4752% (minimum 65%, Uncertain); stomach: 63.8554% (minimum 70%, Missing); thymus: 62.3529% (minimum 65%, Missing); thyroid gland: 49.5327% (minimum 65%, Missing); tongue: 63.0952% (minimum 70%, Missing); urinary bladder: 67.9487% (minimum 70%, Missing)",-0.154673,-0.209259,-0.360294,0,4,partial,8.3,5.5,5.4,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); thyroid gland: 5.4 nTPM (manageable, limit 5); skin: 5.4 nTPM (manageable, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 3); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174206,KICS2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 56.9892% (minimum 75%, Uncertain); amygdala: 65.4321% (minimum 75%, Missing); basal ganglia: 54.6392% (minimum 75%, Missing); cerebellum: 74.6479% (minimum 75%, Uncertain); cerebral cortex: 58.8889% (minimum 75%, Missing); choroid plexus: 74.6479% (minimum 75%, Missing); colon: 66.2500% (minimum 70%, Missing); duodenum: 63.8554% (minimum 75%, Missing); esophagus: 56.3830% (minimum 70%, Uncertain); heart muscle: 70.6667% (minimum 75%, Uncertain); hippocampal formation: 62.3529% (minimum 75%, Missing); hypothalamus: 64.6341% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 38.9706% (minimum 75%, Uncertain); lung: 66.2500% (minimum 75%, Missing); lymph node: 52.4752% (minimum 70%, Uncertain); midbrain: 61.6279% (minimum 75%, Missing); pancreas: 51.4563% (minimum 75%, Missing); parathyroid gland: 49.0741% (minimum 70%, Uncertain); pituitary gland: 67.9487% (minimum 75%, Missing); rectum: 63.8554% (minimum 70%, Missing); salivary gland: 65.4321% (minimum 70%, Uncertain); skeletal muscle: 55.2083% (minimum 75%, Uncertain); skin: 49.5327% (minimum 65%, Uncertain); small intestine: 68.8312% (minimum 75%, Missing); smooth muscle: 70.6667% (minimum 75%, Uncertain); spinal cord: 59.5506% (minimum 75%, Missing); spleen: 52.4752% (minimum 65%, Uncertain); stomach: 63.8554% (minimum 70%, Missing); thymus: 62.3529% (minimum 65%, Missing); thyroid gland: 49.5327% (minimum 65%, Missing); tongue: 63.0952% (minimum 70%, Missing); urinary bladder: 67.9487% (minimum 70%, Missing)",-0.154673,-0.209259,-0.360294,0,4,partial,8.3,5.5,5.4,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); thyroid gland: 5.4 nTPM (manageable, limit 5); skin: 5.4 nTPM (manageable, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 3); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174206,KICS2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 56.9892% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.4321% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.6392% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.6479% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.8889% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.6479% (minimum 75%, Baseline (adaptation disabled)); colon: 66.2500% (minimum 70%, Baseline (adaptation disabled)); duodenum: 63.8554% (minimum 75%, Baseline (adaptation disabled)); esophagus: 56.3830% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.6667% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 62.3529% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.6341% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 38.9706% (minimum 75%, Baseline (adaptation disabled)); lung: 66.2500% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.4752% (minimum 70%, Baseline (adaptation disabled)); midbrain: 61.6279% (minimum 75%, Baseline (adaptation disabled)); pancreas: 51.4563% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.0741% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.9487% (minimum 75%, Baseline (adaptation disabled)); rectum: 63.8554% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 65.4321% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.2083% (minimum 75%, Baseline (adaptation disabled)); skin: 49.5327% (minimum 65%, Baseline (adaptation disabled)); small intestine: 68.8312% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.5506% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.4752% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.8554% (minimum 70%, Baseline (adaptation disabled)); thymus: 62.3529% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 49.5327% (minimum 65%, Baseline (adaptation disabled)); tongue: 63.0952% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.9487% (minimum 70%, Baseline (adaptation disabled))",-0.154673,-0.209259,-0.360294,0,4,partial,8.3,5.5,5.4,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); thyroid gland: 5.4 nTPM (manageable, limit 5); skin: 5.4 nTPM (manageable, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 3); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174206,KICS2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.0392% (minimum 99%, Missing); bone marrow: 98.0392% (minimum 99%, Missing); duodenum: 94.3396% (minimum 99%, Missing); esophagus: 94.3396% (minimum 97%, Missing); heart muscle: 98.0392% (minimum 99%, Missing); lung: 98.0392% (minimum 99%, Missing); retina: 94.3396% (minimum 99%, Missing); skin: 87.7193% (minimum 95%, Missing); small intestine: 96.1538% (minimum 99%, Missing); thyroid gland: 94.3396% (minimum 95%, Missing)",-0.072807,-0.0266038,-0.0466038,0,80,unavailable,0.3,0.3,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174225,ARL13A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.227193,0.243396,0.193396,0,80,unavailable,0.3,0.3,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174225,ARL13A,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.227193,0.243396,0.193396,0,80,unavailable,0.3,0.3,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174225,ARL13A,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.227193,0.243396,0.193396,0,80,unavailable,0.3,0.3,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174225,ARL13A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.227193,0.243396,0.193396,0,80,unavailable,0.3,0.3,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174225,ARL13A,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"colon: 76.3158% (minimum 97%, Missing); rectum: 82.8571% (minimum 97%, Missing)",0.05,-0.206842,0.01,0,80,unavailable,0,0.9,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174279,EVX2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.0631579,0.25,0,80,unavailable,0,0.9,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174279,EVX2,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.0631579,0.25,0,80,unavailable,0,0.9,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174279,EVX2,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.0631579,0.25,0,80,unavailable,0,0.9,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174279,EVX2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.0631579,0.25,0,80,unavailable,0,0.9,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174279,EVX2,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Missing); adrenal gland: 94.8276% (minimum 99%, Missing); amygdala: 96.4912% (minimum 99%, Missing); basal ganglia: 96.4912% (minimum 99%, Missing); bone marrow: 24.3363% (minimum 99%, Missing); cerebral cortex: 90.1639% (minimum 99%, Missing); colon: 63.9535% (minimum 97%, Missing); duodenum: 66.2651% (minimum 99%, Missing); esophagus: 69.6203% (minimum 97%, Missing); heart muscle: 96.4912% (minimum 99%, Missing); hippocampal formation: 96.4912% (minimum 99%, Missing); hypothalamus: 98.2143% (minimum 99%, Missing); kidney: 94.8276% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 91.6667% (minimum 99%, Missing); lymph node: 49.1071% (minimum 97%, Missing); midbrain: 98.2143% (minimum 99%, Missing); pancreas: 94.8276% (minimum 99%, Missing); parathyroid gland: 88.7097% (minimum 97%, Missing); pituitary gland: 98.2143% (minimum 99%, Missing); rectum: 60.4396% (minimum 97%, Missing); salivary gland: 93.2203% (minimum 97%, Missing); skeletal muscle: 98.2143% (minimum 99%, Missing); skin: 75.3425% (minimum 95%, Missing); small intestine: 69.6203% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spinal cord: 98.2143% (minimum 99%, Missing); spleen: 78.5714% (minimum 95%, Missing); stomach: 78.5714% (minimum 97%, Missing); thymus: 33.7423% (minimum 95%, Missing); thyroid gland: 94.8276% (minimum 95%, Missing); urinary bladder: 82.0896% (minimum 97%, Missing)",-0.612577,-0.478929,-0.746637,0,80,unavailable,17.1,5.7,10.8,"bone marrow: 17.1 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 5.7 nTPM (protected, limit 2); rectum: 3.6 nTPM (protected, limit 2); colon: 3.1 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174371,EXO1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 24.3363% (minimum 75%, Missing); colon: 63.9535% (minimum 70%, Missing); duodenum: 66.2651% (minimum 75%, Missing); esophagus: 69.6203% (minimum 70%, Missing); lymph node: 49.1071% (minimum 70%, Missing); rectum: 60.4396% (minimum 70%, Missing); small intestine: 69.6203% (minimum 75%, Missing); thymus: 33.7423% (minimum 65%, Missing)",-0.312577,-0.208929,-0.506637,0,80,unavailable,17.1,5.7,10.8,"bone marrow: 17.1 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 5.7 nTPM (protected, limit 2); rectum: 3.6 nTPM (protected, limit 2); colon: 3.1 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174371,EXO1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 24.3363% (minimum 75%, Missing); colon: 63.9535% (minimum 70%, Missing); duodenum: 66.2651% (minimum 75%, Missing); esophagus: 69.6203% (minimum 70%, Missing); lymph node: 49.1071% (minimum 70%, Missing); rectum: 60.4396% (minimum 70%, Missing); small intestine: 69.6203% (minimum 75%, Missing); thymus: 33.7423% (minimum 65%, Missing)",-0.312577,-0.208929,-0.506637,0,80,unavailable,17.1,5.7,10.8,"bone marrow: 17.1 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 5.7 nTPM (protected, limit 3); rectum: 3.6 nTPM (protected, limit 3); colon: 3.1 nTPM (protected, limit 3); duodenum: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174371,EXO1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 24.3363% (minimum 75%, Missing); colon: 63.9535% (minimum 70%, Missing); duodenum: 66.2651% (minimum 75%, Missing); esophagus: 69.6203% (minimum 70%, Missing); lymph node: 49.1071% (minimum 70%, Missing); rectum: 60.4396% (minimum 70%, Missing); small intestine: 69.6203% (minimum 75%, Missing); thymus: 33.7423% (minimum 65%, Missing)",-0.312577,-0.208929,-0.506637,0,80,unavailable,17.1,5.7,10.8,"bone marrow: 17.1 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 5.7 nTPM (protected, limit 3); rectum: 3.6 nTPM (protected, limit 3); colon: 3.1 nTPM (protected, limit 3); duodenum: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174371,EXO1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 24.3363% (minimum 75%, Baseline (adaptation disabled)); colon: 63.9535% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.2651% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.6203% (minimum 70%, Baseline (adaptation disabled)); lymph node: 49.1071% (minimum 70%, Baseline (adaptation disabled)); rectum: 60.4396% (minimum 70%, Baseline (adaptation disabled)); small intestine: 69.6203% (minimum 75%, Baseline (adaptation disabled)); thymus: 33.7423% (minimum 65%, Baseline (adaptation disabled))",-0.312577,-0.208929,-0.506637,0,80,unavailable,17.1,5.7,10.8,"bone marrow: 17.1 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 5.7 nTPM (protected, limit 3); rectum: 3.6 nTPM (protected, limit 3); colon: 3.1 nTPM (protected, limit 3); duodenum: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174371,EXO1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.7381% (minimum 95%, Missing); adrenal gland: 54.4944% (minimum 99%, Missing); amygdala: 59.8765% (minimum 99%, Missing); basal ganglia: 58.7879% (minimum 99%, Missing); bone marrow: 69.7842% (minimum 99%, Missing); cerebellum: 59.5092% (minimum 99%, Missing); cerebral cortex: 45.1163% (minimum 99%, Missing); choroid plexus: 60.6250% (minimum 99%, Missing); colon: 63.3987% (minimum 97%, Missing); duodenum: 58.0838% (minimum 99%, Missing); esophagus: 69.2857% (minimum 97%, Missing); heart muscle: 59.8765% (minimum 99%, Missing); hippocampal formation: 55.7471% (minimum 99%, Missing); hypothalamus: 53.5912% (minimum 99%, Missing); kidney: 54.8023% (minimum 99%, Missing); liver: 43.4978% (minimum 99%, Missing); lung: 58.0838% (minimum 99%, Missing); lymph node: 46.8599% (minimum 97%, Missing); midbrain: 56.7251% (minimum 99%, Missing); pancreas: 65.5405% (minimum 99%, Missing); parathyroid gland: 46.6346% (minimum 97%, Missing); pituitary gland: 57.7381% (minimum 99%, Missing); rectum: 59.5092% (minimum 97%, Missing); retina: 27.6353% (minimum 99%, Missing); salivary gland: 68.7943% (minimum 97%, Missing); skeletal muscle: 58.0838% (minimum 99%, Missing); skin: 65.5405% (minimum 95%, Missing); small intestine: 58.7879% (minimum 99%, Missing); smooth muscle: 59.1463% (minimum 99%, Missing); spinal cord: 53.2967% (minimum 99%, Missing); spleen: 54.1899% (minimum 95%, Missing); stomach: 55.7471% (minimum 97%, Missing); thymus: 30.9904% (minimum 95%, Missing); thyroid gland: 56.0694% (minimum 95%, Missing); tongue: 60.6250% (minimum 97%, Missing); urinary bladder: 58.7879% (minimum 97%, Missing)",-0.640096,-0.503654,-0.713647,0,8,partial,25.4,11.1,21.6,"retina: 25.4 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); lymph node: 11 nTPM (protected, limit 2); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (manageable, limit 5); midbrain: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 2); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); cerebellum: 6.6 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); colon: 5.6 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); salivary gland: 4.4 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174405,LIG4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.7381% (minimum 65%, Missing); adrenal gland: 54.4944% (minimum 75%, Missing); amygdala: 59.8765% (minimum 75%, Missing); basal ganglia: 58.7879% (minimum 75%, Missing); bone marrow: 69.7842% (minimum 75%, Missing); cerebellum: 59.5092% (minimum 75%, Missing); cerebral cortex: 45.1163% (minimum 75%, Missing); choroid plexus: 60.6250% (minimum 75%, Missing); colon: 63.3987% (minimum 70%, Missing); duodenum: 58.0838% (minimum 75%, Missing); esophagus: 69.2857% (minimum 70%, Missing); heart muscle: 59.8765% (minimum 75%, Missing); hippocampal formation: 55.7471% (minimum 75%, Missing); hypothalamus: 53.5912% (minimum 75%, Missing); kidney: 54.8023% (minimum 75%, Missing); liver: 43.4978% (minimum 75%, Missing); lung: 58.0838% (minimum 75%, Missing); lymph node: 46.8599% (minimum 70%, Missing); midbrain: 56.7251% (minimum 75%, Missing); pancreas: 65.5405% (minimum 75%, Missing); parathyroid gland: 46.6346% (minimum 70%, Missing); pituitary gland: 57.7381% (minimum 75%, Missing); rectum: 59.5092% (minimum 70%, Missing); retina: 27.6353% (minimum 75%, Missing); salivary gland: 68.7943% (minimum 70%, Missing); skeletal muscle: 58.0838% (minimum 75%, Missing); small intestine: 58.7879% (minimum 75%, Missing); smooth muscle: 59.1463% (minimum 75%, Missing); spinal cord: 53.2967% (minimum 75%, Missing); spleen: 54.1899% (minimum 65%, Missing); stomach: 55.7471% (minimum 70%, Missing); thymus: 30.9904% (minimum 65%, Missing); thyroid gland: 56.0694% (minimum 65%, Missing); tongue: 60.6250% (minimum 70%, Missing); urinary bladder: 58.7879% (minimum 70%, Missing)",-0.340096,-0.233654,-0.473647,0,8,partial,25.4,11.1,21.6,"retina: 25.4 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); lymph node: 11 nTPM (protected, limit 2); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (manageable, limit 5); midbrain: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 2); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); cerebellum: 6.6 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); colon: 5.6 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); salivary gland: 4.4 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174405,LIG4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.7381% (minimum 65%, Missing); adrenal gland: 54.4944% (minimum 75%, Missing); amygdala: 59.8765% (minimum 75%, Missing); basal ganglia: 58.7879% (minimum 75%, Missing); bone marrow: 69.7842% (minimum 75%, Missing); cerebellum: 59.5092% (minimum 75%, Missing); cerebral cortex: 45.1163% (minimum 75%, Missing); choroid plexus: 60.6250% (minimum 75%, Missing); colon: 63.3987% (minimum 70%, Missing); duodenum: 58.0838% (minimum 75%, Missing); esophagus: 69.2857% (minimum 70%, Missing); heart muscle: 59.8765% (minimum 75%, Missing); hippocampal formation: 55.7471% (minimum 75%, Missing); hypothalamus: 53.5912% (minimum 75%, Missing); kidney: 54.8023% (minimum 75%, Missing); liver: 43.4978% (minimum 75%, Missing); lung: 58.0838% (minimum 75%, Missing); lymph node: 46.8599% (minimum 70%, Missing); midbrain: 56.7251% (minimum 75%, Missing); pancreas: 65.5405% (minimum 75%, Missing); parathyroid gland: 46.6346% (minimum 70%, Missing); pituitary gland: 57.7381% (minimum 75%, Missing); rectum: 59.5092% (minimum 70%, Missing); retina: 27.6353% (minimum 75%, Missing); salivary gland: 68.7943% (minimum 70%, Missing); skeletal muscle: 58.0838% (minimum 75%, Missing); small intestine: 58.7879% (minimum 75%, Missing); smooth muscle: 59.1463% (minimum 75%, Missing); spinal cord: 53.2967% (minimum 75%, Missing); spleen: 54.1899% (minimum 65%, Missing); stomach: 55.7471% (minimum 70%, Missing); thymus: 30.9904% (minimum 65%, Missing); thyroid gland: 56.0694% (minimum 65%, Missing); tongue: 60.6250% (minimum 70%, Missing); urinary bladder: 58.7879% (minimum 70%, Missing)",-0.340096,-0.233654,-0.473647,0,8,partial,25.4,11.1,21.6,"retina: 25.4 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); lymph node: 11 nTPM (protected, limit 3); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (manageable, limit 5); midbrain: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 3); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); cerebellum: 6.6 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); colon: 5.6 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); salivary gland: 4.4 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174405,LIG4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.7381% (minimum 65%, Missing); adrenal gland: 54.4944% (minimum 75%, Missing); amygdala: 59.8765% (minimum 75%, Missing); basal ganglia: 58.7879% (minimum 75%, Missing); bone marrow: 69.7842% (minimum 75%, Missing); cerebellum: 59.5092% (minimum 75%, Missing); cerebral cortex: 45.1163% (minimum 75%, Missing); choroid plexus: 60.6250% (minimum 75%, Missing); colon: 63.3987% (minimum 70%, Missing); duodenum: 58.0838% (minimum 75%, Missing); esophagus: 69.2857% (minimum 70%, Missing); heart muscle: 59.8765% (minimum 75%, Missing); hippocampal formation: 55.7471% (minimum 75%, Missing); hypothalamus: 53.5912% (minimum 75%, Missing); kidney: 54.8023% (minimum 75%, Missing); liver: 43.4978% (minimum 75%, Missing); lung: 58.0838% (minimum 75%, Missing); lymph node: 46.8599% (minimum 70%, Missing); midbrain: 56.7251% (minimum 75%, Missing); pancreas: 65.5405% (minimum 75%, Missing); parathyroid gland: 46.6346% (minimum 70%, Missing); pituitary gland: 57.7381% (minimum 75%, Missing); rectum: 59.5092% (minimum 70%, Missing); retina: 27.6353% (minimum 75%, Missing); salivary gland: 68.7943% (minimum 70%, Missing); skeletal muscle: 58.0838% (minimum 75%, Missing); small intestine: 58.7879% (minimum 75%, Missing); smooth muscle: 59.1463% (minimum 75%, Missing); spinal cord: 53.2967% (minimum 75%, Missing); spleen: 54.1899% (minimum 65%, Missing); stomach: 55.7471% (minimum 70%, Missing); thymus: 30.9904% (minimum 65%, Missing); thyroid gland: 56.0694% (minimum 65%, Missing); tongue: 60.6250% (minimum 70%, Missing); urinary bladder: 58.7879% (minimum 70%, Missing)",-0.340096,-0.233654,-0.473647,0,8,partial,25.4,11.1,21.6,"retina: 25.4 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); lymph node: 11 nTPM (protected, limit 3); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (manageable, limit 5); midbrain: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 3); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); cerebellum: 6.6 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); colon: 5.6 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); salivary gland: 4.4 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174405,LIG4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.7381% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 54.4944% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.8765% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.7879% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 69.7842% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 59.5092% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 45.1163% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.6250% (minimum 75%, Baseline (adaptation disabled)); colon: 63.3987% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.0838% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.2857% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.8765% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.7471% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.5912% (minimum 75%, Baseline (adaptation disabled)); kidney: 54.8023% (minimum 75%, Baseline (adaptation disabled)); liver: 43.4978% (minimum 75%, Baseline (adaptation disabled)); lung: 58.0838% (minimum 75%, Baseline (adaptation disabled)); lymph node: 46.8599% (minimum 70%, Baseline (adaptation disabled)); midbrain: 56.7251% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.5405% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 46.6346% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 57.7381% (minimum 75%, Baseline (adaptation disabled)); rectum: 59.5092% (minimum 70%, Baseline (adaptation disabled)); retina: 27.6353% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.7943% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 58.0838% (minimum 75%, Baseline (adaptation disabled)); small intestine: 58.7879% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.1463% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.2967% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.1899% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.7471% (minimum 70%, Baseline (adaptation disabled)); thymus: 30.9904% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.0694% (minimum 65%, Baseline (adaptation disabled)); tongue: 60.6250% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.7879% (minimum 70%, Baseline (adaptation disabled))",-0.340096,-0.233654,-0.473647,0,8,partial,25.4,11.1,21.6,"retina: 25.4 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); lymph node: 11 nTPM (protected, limit 3); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (manageable, limit 5); midbrain: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 3); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); cerebellum: 6.6 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); colon: 5.6 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); salivary gland: 4.4 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174405,LIG4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9919% (minimum 95%, Uncertain); adrenal gland: 61.4089% (minimum 99%, Missing); amygdala: 46.7911% (minimum 99%, Missing); basal ganglia: 47.5682% (minimum 99%, Missing); bone marrow: 73.1752% (minimum 99%, Missing); cerebellum: 48.1971% (minimum 99%, Missing); cerebral cortex: 45.9336% (minimum 99%, Missing); choroid plexus: 47.7381% (minimum 99%, Missing); colon: 55.8496% (minimum 97%, Missing); duodenum: 72.5136% (minimum 99%, Missing); esophagus: 72.3827% (minimum 97%, Missing); heart muscle: 49.4451% (minimum 99%, Missing); hippocampal formation: 55.0824% (minimum 99%, Missing); hypothalamus: 49.8137% (minimum 99%, Missing); kidney: 55.6172% (minimum 99%, Missing); liver: 54.1161% (minimum 99%, Missing); lung: 68.0815% (minimum 99%, Missing); lymph node: 63.4494% (minimum 97%, Missing); midbrain: 53.7534% (minimum 99%, Missing); pancreas: 64.8867% (minimum 99%, Missing); parathyroid gland: 55.7719% (minimum 97%, Missing); pituitary gland: 60.1199% (minimum 99%, Missing); rectum: 68.9003% (minimum 97%, Missing); retina: 59.2319% (minimum 99%, Missing); salivary gland: 69.1379% (minimum 97%, Missing); skeletal muscle: 40.8767% (minimum 99%, Missing); skin: 73.1752% (minimum 95%, Missing); small intestine: 67.6223% (minimum 99%, Missing); smooth muscle: 67.2819% (minimum 99%, Uncertain); spinal cord: 61.3150% (minimum 99%, Missing); spleen: 64.3660% (minimum 95%, Missing); stomach: 64.0575% (minimum 97%, Missing); thymus: 65.9539% (minimum 95%, Missing); thyroid gland: 60.5740% (minimum 95%, Missing); tongue: 60.1199% (minimum 97%, Missing); urinary bladder: 60.2102% (minimum 97%, Missing)",-0.34426,-0.412281,-0.581233,0,1,partial,58,31.8,26.1,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 2); colon: 31.7 nTPM (protected, limit 2); retina: 27.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 2); pituitary gland: 26.6 nTPM (vital, limit 1); urinary bladder: 26.5 nTPM (protected, limit 2); thyroid gland: 26.1 nTPM (manageable, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 2); stomach: 22.5 nTPM (protected, limit 2); spleen: 22.2 nTPM (manageable, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); thymus: 20.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 2); salivary gland: 17.9 nTPM (protected, limit 2); esophagus: 15.3 nTPM (protected, limit 2); duodenum: 15.2 nTPM (vital, limit 1); skin: 14.7 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174446,SNAPC5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9919% (minimum 65%, Uncertain); adrenal gland: 61.4089% (minimum 75%, Missing); amygdala: 46.7911% (minimum 75%, Missing); basal ganglia: 47.5682% (minimum 75%, Missing); bone marrow: 73.1752% (minimum 75%, Missing); cerebellum: 48.1971% (minimum 75%, Missing); cerebral cortex: 45.9336% (minimum 75%, Missing); choroid plexus: 47.7381% (minimum 75%, Missing); colon: 55.8496% (minimum 70%, Missing); duodenum: 72.5136% (minimum 75%, Missing); heart muscle: 49.4451% (minimum 75%, Missing); hippocampal formation: 55.0824% (minimum 75%, Missing); hypothalamus: 49.8137% (minimum 75%, Missing); kidney: 55.6172% (minimum 75%, Missing); liver: 54.1161% (minimum 75%, Missing); lung: 68.0815% (minimum 75%, Missing); lymph node: 63.4494% (minimum 70%, Missing); midbrain: 53.7534% (minimum 75%, Missing); pancreas: 64.8867% (minimum 75%, Missing); parathyroid gland: 55.7719% (minimum 70%, Missing); pituitary gland: 60.1199% (minimum 75%, Missing); rectum: 68.9003% (minimum 70%, Missing); retina: 59.2319% (minimum 75%, Missing); salivary gland: 69.1379% (minimum 70%, Missing); skeletal muscle: 40.8767% (minimum 75%, Missing); small intestine: 67.6223% (minimum 75%, Missing); smooth muscle: 67.2819% (minimum 75%, Uncertain); spinal cord: 61.3150% (minimum 75%, Missing); spleen: 64.3660% (minimum 65%, Missing); stomach: 64.0575% (minimum 70%, Missing); thyroid gland: 60.5740% (minimum 65%, Missing); tongue: 60.1199% (minimum 70%, Missing); urinary bladder: 60.2102% (minimum 70%, Missing)",-0.0442598,-0.142281,-0.341233,0,1,partial,58,31.8,26.1,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 2); colon: 31.7 nTPM (protected, limit 2); retina: 27.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 2); pituitary gland: 26.6 nTPM (vital, limit 1); urinary bladder: 26.5 nTPM (protected, limit 2); thyroid gland: 26.1 nTPM (manageable, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 2); stomach: 22.5 nTPM (protected, limit 2); spleen: 22.2 nTPM (manageable, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); thymus: 20.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 2); salivary gland: 17.9 nTPM (protected, limit 2); esophagus: 15.3 nTPM (protected, limit 2); duodenum: 15.2 nTPM (vital, limit 1); skin: 14.7 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174446,SNAPC5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9919% (minimum 65%, Uncertain); adrenal gland: 61.4089% (minimum 75%, Missing); amygdala: 46.7911% (minimum 75%, Missing); basal ganglia: 47.5682% (minimum 75%, Missing); bone marrow: 73.1752% (minimum 75%, Missing); cerebellum: 48.1971% (minimum 75%, Missing); cerebral cortex: 45.9336% (minimum 75%, Missing); choroid plexus: 47.7381% (minimum 75%, Missing); colon: 55.8496% (minimum 70%, Missing); duodenum: 72.5136% (minimum 75%, Missing); heart muscle: 49.4451% (minimum 75%, Missing); hippocampal formation: 55.0824% (minimum 75%, Missing); hypothalamus: 49.8137% (minimum 75%, Missing); kidney: 55.6172% (minimum 75%, Missing); liver: 54.1161% (minimum 75%, Missing); lung: 68.0815% (minimum 75%, Missing); lymph node: 63.4494% (minimum 70%, Missing); midbrain: 53.7534% (minimum 75%, Missing); pancreas: 64.8867% (minimum 75%, Missing); parathyroid gland: 55.7719% (minimum 70%, Missing); pituitary gland: 60.1199% (minimum 75%, Missing); rectum: 68.9003% (minimum 70%, Missing); retina: 59.2319% (minimum 75%, Missing); salivary gland: 69.1379% (minimum 70%, Missing); skeletal muscle: 40.8767% (minimum 75%, Missing); small intestine: 67.6223% (minimum 75%, Missing); smooth muscle: 67.2819% (minimum 75%, Uncertain); spinal cord: 61.3150% (minimum 75%, Missing); spleen: 64.3660% (minimum 65%, Missing); stomach: 64.0575% (minimum 70%, Missing); thyroid gland: 60.5740% (minimum 65%, Missing); tongue: 60.1199% (minimum 70%, Missing); urinary bladder: 60.2102% (minimum 70%, Missing)",-0.0442598,-0.142281,-0.341233,0,1,partial,58,31.8,26.1,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 3); colon: 31.7 nTPM (protected, limit 3); retina: 27.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 3); pituitary gland: 26.6 nTPM (vital, limit 1); urinary bladder: 26.5 nTPM (protected, limit 3); thyroid gland: 26.1 nTPM (manageable, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 3); stomach: 22.5 nTPM (protected, limit 3); spleen: 22.2 nTPM (manageable, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); thymus: 20.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 3); salivary gland: 17.9 nTPM (protected, limit 3); esophagus: 15.3 nTPM (protected, limit 3); duodenum: 15.2 nTPM (vital, limit 1); skin: 14.7 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174446,SNAPC5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9919% (minimum 65%, Uncertain); adrenal gland: 61.4089% (minimum 75%, Missing); amygdala: 46.7911% (minimum 75%, Missing); basal ganglia: 47.5682% (minimum 75%, Missing); bone marrow: 73.1752% (minimum 75%, Missing); cerebellum: 48.1971% (minimum 75%, Missing); cerebral cortex: 45.9336% (minimum 75%, Missing); choroid plexus: 47.7381% (minimum 75%, Missing); colon: 55.8496% (minimum 70%, Missing); duodenum: 72.5136% (minimum 75%, Missing); heart muscle: 49.4451% (minimum 75%, Missing); hippocampal formation: 55.0824% (minimum 75%, Missing); hypothalamus: 49.8137% (minimum 75%, Missing); kidney: 55.6172% (minimum 75%, Missing); liver: 54.1161% (minimum 75%, Missing); lung: 68.0815% (minimum 75%, Missing); lymph node: 63.4494% (minimum 70%, Missing); midbrain: 53.7534% (minimum 75%, Missing); pancreas: 64.8867% (minimum 75%, Missing); parathyroid gland: 55.7719% (minimum 70%, Missing); pituitary gland: 60.1199% (minimum 75%, Missing); rectum: 68.9003% (minimum 70%, Missing); retina: 59.2319% (minimum 75%, Missing); salivary gland: 69.1379% (minimum 70%, Missing); skeletal muscle: 40.8767% (minimum 75%, Missing); small intestine: 67.6223% (minimum 75%, Missing); smooth muscle: 67.2819% (minimum 75%, Uncertain); spinal cord: 61.3150% (minimum 75%, Missing); spleen: 64.3660% (minimum 65%, Missing); stomach: 64.0575% (minimum 70%, Missing); thyroid gland: 60.5740% (minimum 65%, Missing); tongue: 60.1199% (minimum 70%, Missing); urinary bladder: 60.2102% (minimum 70%, Missing)",-0.0442598,-0.142281,-0.341233,0,1,partial,58,31.8,26.1,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 3); colon: 31.7 nTPM (protected, limit 3); retina: 27.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 3); pituitary gland: 26.6 nTPM (vital, limit 1); urinary bladder: 26.5 nTPM (protected, limit 3); thyroid gland: 26.1 nTPM (manageable, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 3); stomach: 22.5 nTPM (protected, limit 3); spleen: 22.2 nTPM (manageable, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); thymus: 20.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 3); salivary gland: 17.9 nTPM (protected, limit 3); esophagus: 15.3 nTPM (protected, limit 3); duodenum: 15.2 nTPM (vital, limit 1); skin: 14.7 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174446,SNAPC5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9919% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 61.4089% (minimum 75%, Baseline (adaptation disabled)); amygdala: 46.7911% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 47.5682% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 73.1752% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.1971% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 45.9336% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 47.7381% (minimum 75%, Baseline (adaptation disabled)); colon: 55.8496% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.5136% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 49.4451% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.0824% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 49.8137% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.6172% (minimum 75%, Baseline (adaptation disabled)); liver: 54.1161% (minimum 75%, Baseline (adaptation disabled)); lung: 68.0815% (minimum 75%, Baseline (adaptation disabled)); lymph node: 63.4494% (minimum 70%, Baseline (adaptation disabled)); midbrain: 53.7534% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.8867% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.7719% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 60.1199% (minimum 75%, Baseline (adaptation disabled)); rectum: 68.9003% (minimum 70%, Baseline (adaptation disabled)); retina: 59.2319% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 69.1379% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 40.8767% (minimum 75%, Baseline (adaptation disabled)); small intestine: 67.6223% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.2819% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.3150% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.3660% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.0575% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 60.5740% (minimum 65%, Baseline (adaptation disabled)); tongue: 60.1199% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.2102% (minimum 70%, Baseline (adaptation disabled))",-0.0442598,-0.142281,-0.341233,0,1,partial,58,31.8,26.1,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 3); colon: 31.7 nTPM (protected, limit 3); retina: 27.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 3); pituitary gland: 26.6 nTPM (vital, limit 1); urinary bladder: 26.5 nTPM (protected, limit 3); thyroid gland: 26.1 nTPM (manageable, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 3); stomach: 22.5 nTPM (protected, limit 3); spleen: 22.2 nTPM (manageable, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); thymus: 20.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 3); salivary gland: 17.9 nTPM (protected, limit 3); esophagus: 15.3 nTPM (protected, limit 3); duodenum: 15.2 nTPM (vital, limit 1); skin: 14.7 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174446,SNAPC5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.7654% (minimum 99%, Missing); basal ganglia: 98.7654% (minimum 99%, Missing); cerebral cortex: 98.7654% (minimum 99%, Missing); hippocampal formation: 98.7654% (minimum 99%, Missing); hypothalamus: 98.7654% (minimum 99%, Missing); midbrain: 98.7654% (minimum 99%, Missing); retina: 98.7654% (minimum 99%, Missing); spinal cord: 96.3855% (minimum 99%, Missing)",0.05,0.03,-0.0261446,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174448,STARD6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.213855,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174448,STARD6,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.213855,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174448,STARD6,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.213855,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174448,STARD6,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.213855,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174448,STARD6,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 97.8389% (minimum 99%, Missing)",0.047996,0.027996,-0.011611,0,80,unavailable,1.1,0.1,0.1,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174450,GOLGA6L2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347996,0.297996,0.228389,0,80,unavailable,1.1,0.1,0.1,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174450,GOLGA6L2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347996,0.297996,0.228389,0,80,unavailable,1.1,0.1,0.1,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174450,GOLGA6L2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347996,0.297996,0.228389,0,80,unavailable,1.1,0.1,0.1,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174450,GOLGA6L2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347996,0.297996,0.228389,0,80,unavailable,1.1,0.1,0.1,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174450,GOLGA6L2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.6542% (minimum 95%, Uncertain); adrenal gland: 64.6778% (minimum 99%, Missing); amygdala: 59.9558% (minimum 99%, Missing); basal ganglia: 54.5272% (minimum 99%, Missing); bone marrow: 90.3333% (minimum 99%, Uncertain); cerebellum: 57.9060% (minimum 99%, Uncertain); cerebral cortex: 52.8265% (minimum 99%, Uncertain); choroid plexus: 57.4153% (minimum 99%, Missing); colon: 60.8989% (minimum 97%, Missing); duodenum: 80.8955% (minimum 99%, Missing); esophagus: 75.6983% (minimum 97%, Uncertain); heart muscle: 73.4417% (minimum 99%, Missing); hippocampal formation: 64.5238% (minimum 99%, Missing); hypothalamus: 62.0137% (minimum 99%, Missing); kidney: 53.7698% (minimum 99%, Missing); liver: 79.9410% (minimum 99%, Missing); lung: 72.8495% (minimum 99%, Uncertain); lymph node: 84.4237% (minimum 97%, Uncertain); midbrain: 68.2620% (minimum 99%, Missing); pancreas: 67.5810% (minimum 99%, Missing); parathyroid gland: 42.4765% (minimum 97%, Missing); pituitary gland: 60.8989% (minimum 99%, Missing); rectum: 79.2398% (minimum 97%, Missing); retina: 56.5762% (minimum 99%, Missing); salivary gland: 62.4424% (minimum 97%, Uncertain); skeletal muscle: 77.6504% (minimum 99%, Uncertain); skin: 74.4505% (minimum 95%, Missing); small intestine: 74.8619% (minimum 99%, Missing); smooth muscle: 66.5848% (minimum 99%, Uncertain); spinal cord: 74.8619% (minimum 99%, Missing); spleen: 82.1212% (minimum 95%, Uncertain); stomach: 66.9136% (minimum 97%, Missing); thymus: 77.8736% (minimum 95%, Missing); thyroid gland: 50.6542% (minimum 95%, Missing); tongue: 77.4286% (minimum 97%, Missing); urinary bladder: 64.5238% (minimum 97%, Uncertain)",-0.443458,-0.545235,-0.461735,0,1,partial,24.2,36.7,26.4,"parathyroid gland: 36.7 nTPM (protected, limit 2); thyroid gland: 26.4 nTPM (manageable, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); pituitary gland: 17.4 nTPM (vital, limit 1); hypothalamus: 16.6 nTPM (vital, limit 1); salivary gland: 16.3 nTPM (protected, limit 2); urinary bladder: 14.9 nTPM (protected, limit 2); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.3 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); tongue: 7.9 nTPM (protected, limit 2); skeletal muscle: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); rectum: 7.1 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 2); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174483,BBS1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.6778% (minimum 75%, Missing); amygdala: 59.9558% (minimum 75%, Missing); basal ganglia: 54.5272% (minimum 75%, Missing); cerebellum: 57.9060% (minimum 75%, Uncertain); cerebral cortex: 52.8265% (minimum 75%, Uncertain); choroid plexus: 57.4153% (minimum 75%, Missing); colon: 60.8989% (minimum 70%, Missing); heart muscle: 73.4417% (minimum 75%, Missing); hippocampal formation: 64.5238% (minimum 75%, Missing); hypothalamus: 62.0137% (minimum 75%, Missing); kidney: 53.7698% (minimum 75%, Missing); lung: 72.8495% (minimum 75%, Uncertain); midbrain: 68.2620% (minimum 75%, Missing); pancreas: 67.5810% (minimum 75%, Missing); parathyroid gland: 42.4765% (minimum 70%, Missing); pituitary gland: 60.8989% (minimum 75%, Missing); retina: 56.5762% (minimum 75%, Missing); salivary gland: 62.4424% (minimum 70%, Uncertain); small intestine: 74.8619% (minimum 75%, Missing); smooth muscle: 66.5848% (minimum 75%, Uncertain); spinal cord: 74.8619% (minimum 75%, Missing); stomach: 66.9136% (minimum 70%, Missing); thyroid gland: 50.6542% (minimum 65%, Missing); urinary bladder: 64.5238% (minimum 70%, Uncertain)",-0.143458,-0.275235,-0.221735,0,1,partial,24.2,36.7,26.4,"parathyroid gland: 36.7 nTPM (protected, limit 2); thyroid gland: 26.4 nTPM (manageable, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); pituitary gland: 17.4 nTPM (vital, limit 1); hypothalamus: 16.6 nTPM (vital, limit 1); salivary gland: 16.3 nTPM (protected, limit 2); urinary bladder: 14.9 nTPM (protected, limit 2); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.3 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); tongue: 7.9 nTPM (protected, limit 2); skeletal muscle: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); rectum: 7.1 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 2); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174483,BBS1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.6778% (minimum 75%, Missing); amygdala: 59.9558% (minimum 75%, Missing); basal ganglia: 54.5272% (minimum 75%, Missing); cerebellum: 57.9060% (minimum 75%, Uncertain); cerebral cortex: 52.8265% (minimum 75%, Uncertain); choroid plexus: 57.4153% (minimum 75%, Missing); colon: 60.8989% (minimum 70%, Missing); heart muscle: 73.4417% (minimum 75%, Missing); hippocampal formation: 64.5238% (minimum 75%, Missing); hypothalamus: 62.0137% (minimum 75%, Missing); kidney: 53.7698% (minimum 75%, Missing); lung: 72.8495% (minimum 75%, Uncertain); midbrain: 68.2620% (minimum 75%, Missing); pancreas: 67.5810% (minimum 75%, Missing); parathyroid gland: 42.4765% (minimum 70%, Missing); pituitary gland: 60.8989% (minimum 75%, Missing); retina: 56.5762% (minimum 75%, Missing); salivary gland: 62.4424% (minimum 70%, Uncertain); small intestine: 74.8619% (minimum 75%, Missing); smooth muscle: 66.5848% (minimum 75%, Uncertain); spinal cord: 74.8619% (minimum 75%, Missing); stomach: 66.9136% (minimum 70%, Missing); thyroid gland: 50.6542% (minimum 65%, Missing); urinary bladder: 64.5238% (minimum 70%, Uncertain)",-0.143458,-0.275235,-0.221735,0,1,partial,24.2,36.7,26.4,"parathyroid gland: 36.7 nTPM (protected, limit 3); thyroid gland: 26.4 nTPM (manageable, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); pituitary gland: 17.4 nTPM (vital, limit 1); hypothalamus: 16.6 nTPM (vital, limit 1); salivary gland: 16.3 nTPM (protected, limit 3); urinary bladder: 14.9 nTPM (protected, limit 3); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.3 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 3); tongue: 7.9 nTPM (protected, limit 3); skeletal muscle: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); rectum: 7.1 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 3); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174483,BBS1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.6778% (minimum 75%, Missing); amygdala: 59.9558% (minimum 75%, Missing); basal ganglia: 54.5272% (minimum 75%, Missing); cerebellum: 57.9060% (minimum 75%, Uncertain); cerebral cortex: 52.8265% (minimum 75%, Uncertain); choroid plexus: 57.4153% (minimum 75%, Missing); colon: 60.8989% (minimum 70%, Missing); heart muscle: 73.4417% (minimum 75%, Missing); hippocampal formation: 64.5238% (minimum 75%, Missing); hypothalamus: 62.0137% (minimum 75%, Missing); kidney: 53.7698% (minimum 75%, Missing); lung: 72.8495% (minimum 75%, Uncertain); midbrain: 68.2620% (minimum 75%, Missing); pancreas: 67.5810% (minimum 75%, Missing); parathyroid gland: 42.4765% (minimum 70%, Missing); pituitary gland: 60.8989% (minimum 75%, Missing); retina: 56.5762% (minimum 75%, Missing); salivary gland: 62.4424% (minimum 70%, Uncertain); small intestine: 74.8619% (minimum 75%, Missing); smooth muscle: 66.5848% (minimum 75%, Uncertain); spinal cord: 74.8619% (minimum 75%, Missing); stomach: 66.9136% (minimum 70%, Missing); thyroid gland: 50.6542% (minimum 65%, Missing); urinary bladder: 64.5238% (minimum 70%, Uncertain)",-0.143458,-0.275235,-0.221735,0,1,partial,24.2,36.7,26.4,"parathyroid gland: 36.7 nTPM (protected, limit 3); thyroid gland: 26.4 nTPM (manageable, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); pituitary gland: 17.4 nTPM (vital, limit 1); hypothalamus: 16.6 nTPM (vital, limit 1); salivary gland: 16.3 nTPM (protected, limit 3); urinary bladder: 14.9 nTPM (protected, limit 3); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.3 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 3); tongue: 7.9 nTPM (protected, limit 3); skeletal muscle: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); rectum: 7.1 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 3); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174483,BBS1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.6778% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.9558% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.5272% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.9060% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 52.8265% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 57.4153% (minimum 75%, Baseline (adaptation disabled)); colon: 60.8989% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 73.4417% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.5238% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.0137% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.7698% (minimum 75%, Baseline (adaptation disabled)); lung: 72.8495% (minimum 75%, Baseline (adaptation disabled)); midbrain: 68.2620% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.5810% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 42.4765% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 60.8989% (minimum 75%, Baseline (adaptation disabled)); retina: 56.5762% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.4424% (minimum 70%, Baseline (adaptation disabled)); small intestine: 74.8619% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.5848% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.8619% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.9136% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 50.6542% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 64.5238% (minimum 70%, Baseline (adaptation disabled))",-0.143458,-0.275235,-0.221735,0,1,partial,24.2,36.7,26.4,"parathyroid gland: 36.7 nTPM (protected, limit 3); thyroid gland: 26.4 nTPM (manageable, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); pituitary gland: 17.4 nTPM (vital, limit 1); hypothalamus: 16.6 nTPM (vital, limit 1); salivary gland: 16.3 nTPM (protected, limit 3); urinary bladder: 14.9 nTPM (protected, limit 3); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.3 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 3); tongue: 7.9 nTPM (protected, limit 3); skeletal muscle: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); rectum: 7.1 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 3); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174483,BBS1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 90.0000% (minimum 95%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); retina: 81.8182% (minimum 99%, Missing); thyroid gland: 90.0000% (minimum 95%, Missing)",-0.05,0.03,-0.24,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174527,MYO1H,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.25,0.3,0,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174527,MYO1H,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.25,0.3,0,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174527,MYO1H,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.25,0.3,0,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174527,MYO1H,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.25,0.3,0,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174527,MYO1H,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.8947% (minimum 99%, Uncertain); colon: 33.3333% (minimum 97%, Uncertain); duodenum: 91.6667% (minimum 99%, Uncertain); kidney: 91.6667% (minimum 99%, Uncertain); pancreas: 91.6667% (minimum 99%, Uncertain); rectum: 55.0000% (minimum 97%, Uncertain); salivary gland: 22.0000% (minimum 97%, Uncertain); skin: 91.6667% (minimum 95%, Uncertain); thyroid gland: 61.1111% (minimum 95%, Uncertain)",-0.338889,-0.75,-0.411053,0,0,routine_complete,0.8,3.9,0.7,"salivary gland: 3.9 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174562,KLK15,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.8947% (minimum 75%, Uncertain); colon: 33.3333% (minimum 70%, Uncertain); rectum: 55.0000% (minimum 70%, Uncertain); salivary gland: 22.0000% (minimum 70%, Uncertain); thyroid gland: 61.1111% (minimum 65%, Uncertain)",-0.0388889,-0.48,-0.171053,0,0,routine_complete,0.8,3.9,0.7,"salivary gland: 3.9 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174562,KLK15,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.8947% (minimum 75%, Uncertain); colon: 33.3333% (minimum 70%, Uncertain); rectum: 55.0000% (minimum 70%, Uncertain); salivary gland: 22.0000% (minimum 70%, Uncertain); thyroid gland: 61.1111% (minimum 65%, Uncertain)",-0.0388889,-0.48,-0.171053,0,0,routine_complete,0.8,3.9,0.7,"salivary gland: 3.9 nTPM (protected, limit 3)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174562,KLK15,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.8947% (minimum 75%, Uncertain); colon: 33.3333% (minimum 70%, Uncertain); rectum: 55.0000% (minimum 70%, Uncertain); salivary gland: 22.0000% (minimum 70%, Uncertain); thyroid gland: 61.1111% (minimum 65%, Uncertain)",-0.0388889,-0.48,-0.171053,0,0,routine_complete,0.8,3.9,0.7,"salivary gland: 3.9 nTPM (protected, limit 3)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174562,KLK15,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.8947% (minimum 75%, Baseline (adaptation disabled)); colon: 33.3333% (minimum 70%, Baseline (adaptation disabled)); rectum: 55.0000% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 22.0000% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 61.1111% (minimum 65%, Baseline (adaptation disabled))",-0.0388889,-0.48,-0.171053,0,0,routine_complete,0.8,3.9,0.7,"salivary gland: 3.9 nTPM (protected, limit 3)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174562,KLK15,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); retina: 25.0000% (minimum 99%, Missing); skeletal muscle: 50.0000% (minimum 99%, Missing); skin: 50.0000% (minimum 95%, Missing); small intestine: 50.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing)",-0.45,0.03,-0.74,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174667,OR7D4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); retina: 25.0000% (minimum 75%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.5,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174667,OR7D4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); retina: 25.0000% (minimum 75%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.5,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174667,OR7D4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); retina: 25.0000% (minimum 75%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.5,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174667,OR7D4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 25.0000% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 50.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 50.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled))",-0.15,0.3,-0.5,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174667,OR7D4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8764% (minimum 99%, Missing); amygdala: 87.1287% (minimum 99%, Missing); basal ganglia: 81.4815% (minimum 99%, Missing); bone marrow: 83.0189% (minimum 99%, Missing); cerebellum: 89.7959% (minimum 99%, Missing); cerebral cortex: 82.2430% (minimum 99%, Missing); choroid plexus: 49.1620% (minimum 99%, Missing); duodenum: 81.4815% (minimum 99%, Missing); esophagus: 90.7216% (minimum 97%, Missing); heart muscle: 81.4815% (minimum 99%, Missing); hippocampal formation: 86.2745% (minimum 99%, Missing); hypothalamus: 79.2793% (minimum 99%, Missing); kidney: 96.7033% (minimum 99%, Missing); lung: 83.8095% (minimum 99%, Missing); lymph node: 96.7033% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 96.7033% (minimum 99%, Missing); pituitary gland: 94.6237% (minimum 99%, Missing); small intestine: 67.1756% (minimum 99%, Missing); smooth muscle: 98.8764% (minimum 99%, Missing); spinal cord: 79.2793% (minimum 99%, Missing)",0.00652174,-0.0627835,-0.49838,0,80,unavailable,9.1,0.9,0.4,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174776,WDR49,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 49.1620% (minimum 75%, Missing); small intestine: 67.1756% (minimum 75%, Missing)",0.306522,0.207216,-0.25838,0,80,unavailable,9.1,0.9,0.4,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174776,WDR49,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 49.1620% (minimum 75%, Missing); small intestine: 67.1756% (minimum 75%, Missing)",0.306522,0.207216,-0.25838,0,80,unavailable,9.1,0.9,0.4,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174776,WDR49,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 49.1620% (minimum 75%, Missing); small intestine: 67.1756% (minimum 75%, Missing)",0.306522,0.207216,-0.25838,0,80,unavailable,9.1,0.9,0.4,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174776,WDR49,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 49.1620% (minimum 75%, Baseline (adaptation disabled)); small intestine: 67.1756% (minimum 75%, Baseline (adaptation disabled))",0.306522,0.207216,-0.25838,0,80,unavailable,9.1,0.9,0.4,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174776,WDR49,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5573% (minimum 99%, Missing); bone marrow: 96.7257% (minimum 99%, Missing); cerebellum: 48.4701% (minimum 99%, Missing); duodenum: 98.8246% (minimum 99%, Missing); heart muscle: 98.1149% (minimum 99%, Missing); hypothalamus: 94.3054% (minimum 99%, Missing); kidney: 93.3390% (minimum 99%, Missing); liver: 96.8113% (minimum 99%, Missing); lung: 98.0269% (minimum 99%, Missing); pancreas: 95.4585% (minimum 99%, Missing); pituitary gland: 98.8246% (minimum 99%, Missing); retina: 77.1893% (minimum 99%, Missing); salivary gland: 87.3701% (minimum 97%, Missing); skin: 94.1430% (minimum 95%, Missing); small intestine: 98.5573% (minimum 99%, Missing); spinal cord: 95.3752% (minimum 99%, Missing)",-0.0085702,-0.096299,-0.505299,0,80,unavailable,116.2,15.8,6.8,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); salivary gland: 15.8 nTPM (protected, limit 2); kidney: 7.8 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174788,PCP2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 48.4701% (minimum 75%, Missing)",0.29143,0.173701,-0.265299,0,80,unavailable,116.2,15.8,6.8,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); salivary gland: 15.8 nTPM (protected, limit 2); kidney: 7.8 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174788,PCP2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 48.4701% (minimum 75%, Missing)",0.29143,0.173701,-0.265299,0,80,unavailable,116.2,15.8,6.8,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); salivary gland: 15.8 nTPM (protected, limit 3); kidney: 7.8 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174788,PCP2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 48.4701% (minimum 75%, Missing)",0.29143,0.173701,-0.265299,0,80,unavailable,116.2,15.8,6.8,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); salivary gland: 15.8 nTPM (protected, limit 3); kidney: 7.8 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174788,PCP2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 48.4701% (minimum 75%, Baseline (adaptation disabled))",0.29143,0.173701,-0.265299,0,80,unavailable,116.2,15.8,6.8,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); salivary gland: 15.8 nTPM (protected, limit 3); kidney: 7.8 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174788,PCP2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.6422% (minimum 95%, Missing); adrenal gland: 67.5439% (minimum 99%, Missing); amygdala: 79.9308% (minimum 99%, Missing); basal ganglia: 79.3814% (minimum 99%, Missing); bone marrow: 65.0704% (minimum 99%, Missing); cerebellum: 66.9565% (minimum 99%, Missing); cerebral cortex: 65.0704% (minimum 99%, Missing); choroid plexus: 78.0405% (minimum 99%, Missing); colon: 70.6422% (minimum 97%, Missing); duodenum: 65.6250% (minimum 99%, Missing); esophagus: 71.0769% (minimum 97%, Missing); heart muscle: 62.2642% (minimum 99%, Missing); hippocampal formation: 79.1096% (minimum 99%, Missing); hypothalamus: 79.1096% (minimum 99%, Missing); kidney: 70.6422% (minimum 99%, Missing); liver: 65.6250% (minimum 99%, Missing); lung: 71.7391% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 77.2575% (minimum 99%, Missing); pancreas: 73.5669% (minimum 99%, Missing); parathyroid gland: 66.0000% (minimum 97%, Missing); pituitary gland: 71.5170% (minimum 99%, Missing); rectum: 66.9565% (minimum 97%, Missing); retina: 52.3810% (minimum 99%, Missing); salivary gland: 63.9889% (minimum 97%, Missing); skeletal muscle: 60.6299% (minimum 99%, Missing); skin: 58.7786% (minimum 95%, Missing); small intestine: 64.5251% (minimum 99%, Missing); smooth muscle: 69.1617% (minimum 99%, Missing); spinal cord: 71.7391% (minimum 99%, Missing); spleen: 65.2542% (minimum 95%, Missing); stomach: 68.5460% (minimum 97%, Missing); thymus: 72.1875% (minimum 95%, Missing); thyroid gland: 60.6299% (minimum 95%, Missing); tongue: 63.9889% (minimum 97%, Missing); urinary bladder: 72.1875% (minimum 97%, Missing)",-0.362214,-0.37,-0.46619,0,80,unavailable,21,15.4,16.2,"retina: 21 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); lymph node: 15.4 nTPM (protected, limit 2); skeletal muscle: 15 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); heart muscle: 14 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 2); tongue: 13 nTPM (protected, limit 2); small intestine: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); duodenum: 12.1 nTPM (vital, limit 1); liver: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 2); cerebellum: 11.4 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 2); smooth muscle: 10.3 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); kidney: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 2); pituitary gland: 9.2 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174796,THAP6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.5439% (minimum 75%, Missing); bone marrow: 65.0704% (minimum 75%, Missing); cerebellum: 66.9565% (minimum 75%, Missing); cerebral cortex: 65.0704% (minimum 75%, Missing); duodenum: 65.6250% (minimum 75%, Missing); heart muscle: 62.2642% (minimum 75%, Missing); kidney: 70.6422% (minimum 75%, Missing); liver: 65.6250% (minimum 75%, Missing); lung: 71.7391% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 73.5669% (minimum 75%, Missing); parathyroid gland: 66.0000% (minimum 70%, Missing); pituitary gland: 71.5170% (minimum 75%, Missing); rectum: 66.9565% (minimum 70%, Missing); retina: 52.3810% (minimum 75%, Missing); salivary gland: 63.9889% (minimum 70%, Missing); skeletal muscle: 60.6299% (minimum 75%, Missing); skin: 58.7786% (minimum 65%, Missing); small intestine: 64.5251% (minimum 75%, Missing); smooth muscle: 69.1617% (minimum 75%, Missing); spinal cord: 71.7391% (minimum 75%, Missing); stomach: 68.5460% (minimum 70%, Missing); thyroid gland: 60.6299% (minimum 65%, Missing); tongue: 63.9889% (minimum 70%, Missing)",-0.0622137,-0.1,-0.22619,0,80,unavailable,21,15.4,16.2,"retina: 21 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); lymph node: 15.4 nTPM (protected, limit 2); skeletal muscle: 15 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); heart muscle: 14 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 2); tongue: 13 nTPM (protected, limit 2); small intestine: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); duodenum: 12.1 nTPM (vital, limit 1); liver: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 2); cerebellum: 11.4 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 2); smooth muscle: 10.3 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); kidney: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 2); pituitary gland: 9.2 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174796,THAP6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.5439% (minimum 75%, Missing); bone marrow: 65.0704% (minimum 75%, Missing); cerebellum: 66.9565% (minimum 75%, Missing); cerebral cortex: 65.0704% (minimum 75%, Missing); duodenum: 65.6250% (minimum 75%, Missing); heart muscle: 62.2642% (minimum 75%, Missing); kidney: 70.6422% (minimum 75%, Missing); liver: 65.6250% (minimum 75%, Missing); lung: 71.7391% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 73.5669% (minimum 75%, Missing); parathyroid gland: 66.0000% (minimum 70%, Missing); pituitary gland: 71.5170% (minimum 75%, Missing); rectum: 66.9565% (minimum 70%, Missing); retina: 52.3810% (minimum 75%, Missing); salivary gland: 63.9889% (minimum 70%, Missing); skeletal muscle: 60.6299% (minimum 75%, Missing); skin: 58.7786% (minimum 65%, Missing); small intestine: 64.5251% (minimum 75%, Missing); smooth muscle: 69.1617% (minimum 75%, Missing); spinal cord: 71.7391% (minimum 75%, Missing); stomach: 68.5460% (minimum 70%, Missing); thyroid gland: 60.6299% (minimum 65%, Missing); tongue: 63.9889% (minimum 70%, Missing)",-0.0622137,-0.1,-0.22619,0,80,unavailable,21,15.4,16.2,"retina: 21 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); lymph node: 15.4 nTPM (protected, limit 3); skeletal muscle: 15 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); heart muscle: 14 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 3); tongue: 13 nTPM (protected, limit 3); small intestine: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); duodenum: 12.1 nTPM (vital, limit 1); liver: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 3); cerebellum: 11.4 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 3); smooth muscle: 10.3 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 3); kidney: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174796,THAP6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.5439% (minimum 75%, Missing); bone marrow: 65.0704% (minimum 75%, Missing); cerebellum: 66.9565% (minimum 75%, Missing); cerebral cortex: 65.0704% (minimum 75%, Missing); duodenum: 65.6250% (minimum 75%, Missing); heart muscle: 62.2642% (minimum 75%, Missing); kidney: 70.6422% (minimum 75%, Missing); liver: 65.6250% (minimum 75%, Missing); lung: 71.7391% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 73.5669% (minimum 75%, Missing); parathyroid gland: 66.0000% (minimum 70%, Missing); pituitary gland: 71.5170% (minimum 75%, Missing); rectum: 66.9565% (minimum 70%, Missing); retina: 52.3810% (minimum 75%, Missing); salivary gland: 63.9889% (minimum 70%, Missing); skeletal muscle: 60.6299% (minimum 75%, Missing); skin: 58.7786% (minimum 65%, Missing); small intestine: 64.5251% (minimum 75%, Missing); smooth muscle: 69.1617% (minimum 75%, Missing); spinal cord: 71.7391% (minimum 75%, Missing); stomach: 68.5460% (minimum 70%, Missing); thyroid gland: 60.6299% (minimum 65%, Missing); tongue: 63.9889% (minimum 70%, Missing)",-0.0622137,-0.1,-0.22619,0,80,unavailable,21,15.4,16.2,"retina: 21 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); lymph node: 15.4 nTPM (protected, limit 3); skeletal muscle: 15 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); heart muscle: 14 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 3); tongue: 13 nTPM (protected, limit 3); small intestine: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); duodenum: 12.1 nTPM (vital, limit 1); liver: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 3); cerebellum: 11.4 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 3); smooth muscle: 10.3 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 3); kidney: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174796,THAP6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.5439% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 65.0704% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 66.9565% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.0704% (minimum 75%, Baseline (adaptation disabled)); duodenum: 65.6250% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 62.2642% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.6422% (minimum 75%, Baseline (adaptation disabled)); liver: 65.6250% (minimum 75%, Baseline (adaptation disabled)); lung: 71.7391% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 73.5669% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.0000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.5170% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.9565% (minimum 70%, Baseline (adaptation disabled)); retina: 52.3810% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.9889% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.6299% (minimum 75%, Baseline (adaptation disabled)); skin: 58.7786% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.5251% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 69.1617% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.7391% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.5460% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 60.6299% (minimum 65%, Baseline (adaptation disabled)); tongue: 63.9889% (minimum 70%, Baseline (adaptation disabled))",-0.0622137,-0.1,-0.22619,0,80,unavailable,21,15.4,16.2,"retina: 21 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); lymph node: 15.4 nTPM (protected, limit 3); skeletal muscle: 15 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); heart muscle: 14 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 3); tongue: 13 nTPM (protected, limit 3); small intestine: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); duodenum: 12.1 nTPM (vital, limit 1); liver: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 3); cerebellum: 11.4 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 3); smooth muscle: 10.3 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 3); kidney: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174796,THAP6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.4670% (minimum 95%, Missing); adrenal gland: 34.7028% (minimum 99%, Missing); amygdala: 42.7055% (minimum 99%, Missing); basal ganglia: 46.9055% (minimum 99%, Missing); bone marrow: 58.6691% (minimum 99%, Missing); cerebellum: 56.1533% (minimum 99%, Missing); cerebral cortex: 45.3856% (minimum 99%, Missing); choroid plexus: 44.9067% (minimum 99%, Missing); colon: 42.3136% (minimum 97%, Missing); duodenum: 64.6320% (minimum 99%, Missing); esophagus: 44.5541% (minimum 97%, Missing); heart muscle: 24.9746% (minimum 99%, Missing); hippocampal formation: 46.9951% (minimum 99%, Missing); hypothalamus: 44.5900% (minimum 99%, Missing); kidney: 43.9523% (minimum 99%, Missing); liver: 37.3502% (minimum 99%, Missing); lung: 59.5373% (minimum 99%, Missing); lymph node: 60.9810% (minimum 97%, Missing); midbrain: 42.8461% (minimum 99%, Missing); pancreas: 52.5528% (minimum 99%, Missing); parathyroid gland: 62.3556% (minimum 97%, Missing); pituitary gland: 52.4656% (minimum 99%, Missing); rectum: 80.3267% (minimum 97%, Missing); retina: 87.8175% (minimum 99%, Missing); salivary gland: 49.6857% (minimum 97%, Missing); skeletal muscle: 35.0214% (minimum 99%, Missing); skin: 54.8995% (minimum 95%, Missing); small intestine: 55.1046% (minimum 99%, Missing); smooth muscle: 71.9909% (minimum 99%, Missing); spinal cord: 46.1715% (minimum 99%, Missing); spleen: 53.5835% (minimum 95%, Missing); stomach: 47.6734% (minimum 97%, Missing); thymus: 65.3574% (minimum 95%, Missing); thyroid gland: 54.7095% (minimum 95%, Missing); tongue: 41.1033% (minimum 97%, Missing); urinary bladder: 52.2180% (minimum 97%, Missing)",-0.41533,-0.558967,-0.740254,0,80,unavailable,664.8,317.1,192.6,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 2); colon: 301.7 nTPM (protected, limit 2); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 2); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 2); salivary gland: 224.1 nTPM (protected, limit 2); urinary bladder: 202.5 nTPM (protected, limit 2); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (manageable, limit 5); spleen: 191.7 nTPM (manageable, limit 5); thyroid gland: 183.2 nTPM (manageable, limit 5); skin: 181.8 nTPM (manageable, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 2); parathyroid gland: 133.6 nTPM (protected, limit 2); duodenum: 121.1 nTPM (vital, limit 1); thymus: 117.3 nTPM (manageable, limit 5); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 2); retina: 30.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174886,NDUFA11,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.4670% (minimum 65%, Missing); adrenal gland: 34.7028% (minimum 75%, Missing); amygdala: 42.7055% (minimum 75%, Missing); basal ganglia: 46.9055% (minimum 75%, Missing); bone marrow: 58.6691% (minimum 75%, Missing); cerebellum: 56.1533% (minimum 75%, Missing); cerebral cortex: 45.3856% (minimum 75%, Missing); choroid plexus: 44.9067% (minimum 75%, Missing); colon: 42.3136% (minimum 70%, Missing); duodenum: 64.6320% (minimum 75%, Missing); esophagus: 44.5541% (minimum 70%, Missing); heart muscle: 24.9746% (minimum 75%, Missing); hippocampal formation: 46.9951% (minimum 75%, Missing); hypothalamus: 44.5900% (minimum 75%, Missing); kidney: 43.9523% (minimum 75%, Missing); liver: 37.3502% (minimum 75%, Missing); lung: 59.5373% (minimum 75%, Missing); lymph node: 60.9810% (minimum 70%, Missing); midbrain: 42.8461% (minimum 75%, Missing); pancreas: 52.5528% (minimum 75%, Missing); parathyroid gland: 62.3556% (minimum 70%, Missing); pituitary gland: 52.4656% (minimum 75%, Missing); salivary gland: 49.6857% (minimum 70%, Missing); skeletal muscle: 35.0214% (minimum 75%, Missing); skin: 54.8995% (minimum 65%, Missing); small intestine: 55.1046% (minimum 75%, Missing); smooth muscle: 71.9909% (minimum 75%, Missing); spinal cord: 46.1715% (minimum 75%, Missing); spleen: 53.5835% (minimum 65%, Missing); stomach: 47.6734% (minimum 70%, Missing); thyroid gland: 54.7095% (minimum 65%, Missing); tongue: 41.1033% (minimum 70%, Missing); urinary bladder: 52.2180% (minimum 70%, Missing)",-0.11533,-0.288967,-0.500254,0,80,unavailable,664.8,317.1,192.6,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 2); colon: 301.7 nTPM (protected, limit 2); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 2); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 2); salivary gland: 224.1 nTPM (protected, limit 2); urinary bladder: 202.5 nTPM (protected, limit 2); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (manageable, limit 5); spleen: 191.7 nTPM (manageable, limit 5); thyroid gland: 183.2 nTPM (manageable, limit 5); skin: 181.8 nTPM (manageable, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 2); parathyroid gland: 133.6 nTPM (protected, limit 2); duodenum: 121.1 nTPM (vital, limit 1); thymus: 117.3 nTPM (manageable, limit 5); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 2); retina: 30.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174886,NDUFA11,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.4670% (minimum 65%, Missing); adrenal gland: 34.7028% (minimum 75%, Missing); amygdala: 42.7055% (minimum 75%, Missing); basal ganglia: 46.9055% (minimum 75%, Missing); bone marrow: 58.6691% (minimum 75%, Missing); cerebellum: 56.1533% (minimum 75%, Missing); cerebral cortex: 45.3856% (minimum 75%, Missing); choroid plexus: 44.9067% (minimum 75%, Missing); colon: 42.3136% (minimum 70%, Missing); duodenum: 64.6320% (minimum 75%, Missing); esophagus: 44.5541% (minimum 70%, Missing); heart muscle: 24.9746% (minimum 75%, Missing); hippocampal formation: 46.9951% (minimum 75%, Missing); hypothalamus: 44.5900% (minimum 75%, Missing); kidney: 43.9523% (minimum 75%, Missing); liver: 37.3502% (minimum 75%, Missing); lung: 59.5373% (minimum 75%, Missing); lymph node: 60.9810% (minimum 70%, Missing); midbrain: 42.8461% (minimum 75%, Missing); pancreas: 52.5528% (minimum 75%, Missing); parathyroid gland: 62.3556% (minimum 70%, Missing); pituitary gland: 52.4656% (minimum 75%, Missing); salivary gland: 49.6857% (minimum 70%, Missing); skeletal muscle: 35.0214% (minimum 75%, Missing); skin: 54.8995% (minimum 65%, Missing); small intestine: 55.1046% (minimum 75%, Missing); smooth muscle: 71.9909% (minimum 75%, Missing); spinal cord: 46.1715% (minimum 75%, Missing); spleen: 53.5835% (minimum 65%, Missing); stomach: 47.6734% (minimum 70%, Missing); thyroid gland: 54.7095% (minimum 65%, Missing); tongue: 41.1033% (minimum 70%, Missing); urinary bladder: 52.2180% (minimum 70%, Missing)",-0.11533,-0.288967,-0.500254,0,80,unavailable,664.8,317.1,192.6,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 3); colon: 301.7 nTPM (protected, limit 3); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 3); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 3); salivary gland: 224.1 nTPM (protected, limit 3); urinary bladder: 202.5 nTPM (protected, limit 3); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (manageable, limit 5); spleen: 191.7 nTPM (manageable, limit 5); thyroid gland: 183.2 nTPM (manageable, limit 5); skin: 181.8 nTPM (manageable, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 3); parathyroid gland: 133.6 nTPM (protected, limit 3); duodenum: 121.1 nTPM (vital, limit 1); thymus: 117.3 nTPM (manageable, limit 5); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 3); retina: 30.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174886,NDUFA11,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.4670% (minimum 65%, Missing); adrenal gland: 34.7028% (minimum 75%, Missing); amygdala: 42.7055% (minimum 75%, Missing); basal ganglia: 46.9055% (minimum 75%, Missing); bone marrow: 58.6691% (minimum 75%, Missing); cerebellum: 56.1533% (minimum 75%, Missing); cerebral cortex: 45.3856% (minimum 75%, Missing); choroid plexus: 44.9067% (minimum 75%, Missing); colon: 42.3136% (minimum 70%, Missing); duodenum: 64.6320% (minimum 75%, Missing); esophagus: 44.5541% (minimum 70%, Missing); heart muscle: 24.9746% (minimum 75%, Missing); hippocampal formation: 46.9951% (minimum 75%, Missing); hypothalamus: 44.5900% (minimum 75%, Missing); kidney: 43.9523% (minimum 75%, Missing); liver: 37.3502% (minimum 75%, Missing); lung: 59.5373% (minimum 75%, Missing); lymph node: 60.9810% (minimum 70%, Missing); midbrain: 42.8461% (minimum 75%, Missing); pancreas: 52.5528% (minimum 75%, Missing); parathyroid gland: 62.3556% (minimum 70%, Missing); pituitary gland: 52.4656% (minimum 75%, Missing); salivary gland: 49.6857% (minimum 70%, Missing); skeletal muscle: 35.0214% (minimum 75%, Missing); skin: 54.8995% (minimum 65%, Missing); small intestine: 55.1046% (minimum 75%, Missing); smooth muscle: 71.9909% (minimum 75%, Missing); spinal cord: 46.1715% (minimum 75%, Missing); spleen: 53.5835% (minimum 65%, Missing); stomach: 47.6734% (minimum 70%, Missing); thyroid gland: 54.7095% (minimum 65%, Missing); tongue: 41.1033% (minimum 70%, Missing); urinary bladder: 52.2180% (minimum 70%, Missing)",-0.11533,-0.288967,-0.500254,0,80,unavailable,664.8,317.1,192.6,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 3); colon: 301.7 nTPM (protected, limit 3); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 3); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 3); salivary gland: 224.1 nTPM (protected, limit 3); urinary bladder: 202.5 nTPM (protected, limit 3); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (manageable, limit 5); spleen: 191.7 nTPM (manageable, limit 5); thyroid gland: 183.2 nTPM (manageable, limit 5); skin: 181.8 nTPM (manageable, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 3); parathyroid gland: 133.6 nTPM (protected, limit 3); duodenum: 121.1 nTPM (vital, limit 1); thymus: 117.3 nTPM (manageable, limit 5); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 3); retina: 30.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174886,NDUFA11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.4670% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 34.7028% (minimum 75%, Baseline (adaptation disabled)); amygdala: 42.7055% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 46.9055% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 58.6691% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.1533% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 45.3856% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 44.9067% (minimum 75%, Baseline (adaptation disabled)); colon: 42.3136% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.6320% (minimum 75%, Baseline (adaptation disabled)); esophagus: 44.5541% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 24.9746% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 46.9951% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 44.5900% (minimum 75%, Baseline (adaptation disabled)); kidney: 43.9523% (minimum 75%, Baseline (adaptation disabled)); liver: 37.3502% (minimum 75%, Baseline (adaptation disabled)); lung: 59.5373% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.9810% (minimum 70%, Baseline (adaptation disabled)); midbrain: 42.8461% (minimum 75%, Baseline (adaptation disabled)); pancreas: 52.5528% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.3556% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 52.4656% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 49.6857% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 35.0214% (minimum 75%, Baseline (adaptation disabled)); skin: 54.8995% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.1046% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.9909% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 46.1715% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.5835% (minimum 65%, Baseline (adaptation disabled)); stomach: 47.6734% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 54.7095% (minimum 65%, Baseline (adaptation disabled)); tongue: 41.1033% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.2180% (minimum 70%, Baseline (adaptation disabled))",-0.11533,-0.288967,-0.500254,0,80,unavailable,664.8,317.1,192.6,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 3); colon: 301.7 nTPM (protected, limit 3); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 3); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 3); salivary gland: 224.1 nTPM (protected, limit 3); urinary bladder: 202.5 nTPM (protected, limit 3); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (manageable, limit 5); spleen: 191.7 nTPM (manageable, limit 5); thyroid gland: 183.2 nTPM (manageable, limit 5); skin: 181.8 nTPM (manageable, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 3); parathyroid gland: 133.6 nTPM (protected, limit 3); duodenum: 121.1 nTPM (vital, limit 1); thymus: 117.3 nTPM (manageable, limit 5); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 3); retina: 30.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174886,NDUFA11,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174898,CATSPERD,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174898,CATSPERD,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174898,CATSPERD,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174898,CATSPERD,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000174898,CATSPERD,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"smooth muscle: 98.4848% (minimum 99%, Missing)",0.0385932,0.0223664,-0.00515152,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175018,TEX36,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338593,0.292366,0.234848,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175018,TEX36,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338593,0.292366,0.234848,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175018,TEX36,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338593,0.292366,0.234848,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175018,TEX36,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338593,0.292366,0.234848,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175018,TEX36,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 95%, Missing); adrenal gland: 61.1111% (minimum 99%, Missing); amygdala: 66.2651% (minimum 99%, Missing); basal ganglia: 65.4762% (minimum 99%, Missing); bone marrow: 21.5686% (minimum 99%, Missing); cerebellum: 65.4762% (minimum 99%, Missing); cerebral cortex: 49.1071% (minimum 99%, Missing); choroid plexus: 77.4648% (minimum 99%, Missing); colon: 56.1224% (minimum 97%, Missing); duodenum: 59.7826% (minimum 99%, Missing); esophagus: 62.5000% (minimum 97%, Missing); heart muscle: 66.2651% (minimum 99%, Missing); hippocampal formation: 64.7059% (minimum 99%, Missing); hypothalamus: 66.2651% (minimum 99%, Missing); kidney: 56.7010% (minimum 99%, Missing); liver: 44.7154% (minimum 99%, Missing); lung: 57.8947% (minimum 99%, Missing); lymph node: 39.8551% (minimum 97%, Missing); midbrain: 66.2651% (minimum 99%, Missing); pancreas: 58.5106% (minimum 99%, Missing); parathyroid gland: 50.4587% (minimum 97%, Missing); pituitary gland: 78.5714% (minimum 99%, Missing); rectum: 58.5106% (minimum 97%, Missing); retina: 55.5556% (minimum 99%, Missing); salivary gland: 57.2917% (minimum 97%, Missing); skeletal muscle: 51.8868% (minimum 99%, Missing); skin: 63.2184% (minimum 95%, Missing); small intestine: 61.1111% (minimum 99%, Missing); smooth muscle: 63.2184% (minimum 99%, Missing); spinal cord: 67.9012% (minimum 99%, Missing); spleen: 39.0071% (minimum 95%, Missing); stomach: 55.5556% (minimum 97%, Missing); thymus: 51.4019% (minimum 95%, Missing); thyroid gland: 57.2917% (minimum 95%, Missing); tongue: 51.8868% (minimum 97%, Missing); urinary bladder: 57.8947% (minimum 97%, Missing)",-0.559929,-0.571449,-0.774314,0,80,unavailable,20,8.3,8.6,"bone marrow: 20 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 2); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); retina: 4.4 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); esophagus: 3.3 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175073,VCPIP1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 65%, Missing); adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 66.2651% (minimum 75%, Missing); basal ganglia: 65.4762% (minimum 75%, Missing); bone marrow: 21.5686% (minimum 75%, Missing); cerebellum: 65.4762% (minimum 75%, Missing); cerebral cortex: 49.1071% (minimum 75%, Missing); colon: 56.1224% (minimum 70%, Missing); duodenum: 59.7826% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); heart muscle: 66.2651% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); hypothalamus: 66.2651% (minimum 75%, Missing); kidney: 56.7010% (minimum 75%, Missing); liver: 44.7154% (minimum 75%, Missing); lung: 57.8947% (minimum 75%, Missing); lymph node: 39.8551% (minimum 70%, Missing); midbrain: 66.2651% (minimum 75%, Missing); pancreas: 58.5106% (minimum 75%, Missing); parathyroid gland: 50.4587% (minimum 70%, Missing); rectum: 58.5106% (minimum 70%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 57.2917% (minimum 70%, Missing); skeletal muscle: 51.8868% (minimum 75%, Missing); skin: 63.2184% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); smooth muscle: 63.2184% (minimum 75%, Missing); spinal cord: 67.9012% (minimum 75%, Missing); spleen: 39.0071% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 51.4019% (minimum 65%, Missing); thyroid gland: 57.2917% (minimum 65%, Missing); tongue: 51.8868% (minimum 70%, Missing); urinary bladder: 57.8947% (minimum 70%, Missing)",-0.259929,-0.301449,-0.534314,0,80,unavailable,20,8.3,8.6,"bone marrow: 20 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 2); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); retina: 4.4 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); esophagus: 3.3 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175073,VCPIP1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 65%, Missing); adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 66.2651% (minimum 75%, Missing); basal ganglia: 65.4762% (minimum 75%, Missing); bone marrow: 21.5686% (minimum 75%, Missing); cerebellum: 65.4762% (minimum 75%, Missing); cerebral cortex: 49.1071% (minimum 75%, Missing); colon: 56.1224% (minimum 70%, Missing); duodenum: 59.7826% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); heart muscle: 66.2651% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); hypothalamus: 66.2651% (minimum 75%, Missing); kidney: 56.7010% (minimum 75%, Missing); liver: 44.7154% (minimum 75%, Missing); lung: 57.8947% (minimum 75%, Missing); lymph node: 39.8551% (minimum 70%, Missing); midbrain: 66.2651% (minimum 75%, Missing); pancreas: 58.5106% (minimum 75%, Missing); parathyroid gland: 50.4587% (minimum 70%, Missing); rectum: 58.5106% (minimum 70%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 57.2917% (minimum 70%, Missing); skeletal muscle: 51.8868% (minimum 75%, Missing); skin: 63.2184% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); smooth muscle: 63.2184% (minimum 75%, Missing); spinal cord: 67.9012% (minimum 75%, Missing); spleen: 39.0071% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 51.4019% (minimum 65%, Missing); thyroid gland: 57.2917% (minimum 65%, Missing); tongue: 51.8868% (minimum 70%, Missing); urinary bladder: 57.8947% (minimum 70%, Missing)",-0.259929,-0.301449,-0.534314,0,80,unavailable,20,8.3,8.6,"bone marrow: 20 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 3); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); retina: 4.4 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 3); lung: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); esophagus: 3.3 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175073,VCPIP1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 65%, Missing); adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 66.2651% (minimum 75%, Missing); basal ganglia: 65.4762% (minimum 75%, Missing); bone marrow: 21.5686% (minimum 75%, Missing); cerebellum: 65.4762% (minimum 75%, Missing); cerebral cortex: 49.1071% (minimum 75%, Missing); colon: 56.1224% (minimum 70%, Missing); duodenum: 59.7826% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); heart muscle: 66.2651% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); hypothalamus: 66.2651% (minimum 75%, Missing); kidney: 56.7010% (minimum 75%, Missing); liver: 44.7154% (minimum 75%, Missing); lung: 57.8947% (minimum 75%, Missing); lymph node: 39.8551% (minimum 70%, Missing); midbrain: 66.2651% (minimum 75%, Missing); pancreas: 58.5106% (minimum 75%, Missing); parathyroid gland: 50.4587% (minimum 70%, Missing); rectum: 58.5106% (minimum 70%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 57.2917% (minimum 70%, Missing); skeletal muscle: 51.8868% (minimum 75%, Missing); skin: 63.2184% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); smooth muscle: 63.2184% (minimum 75%, Missing); spinal cord: 67.9012% (minimum 75%, Missing); spleen: 39.0071% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 51.4019% (minimum 65%, Missing); thyroid gland: 57.2917% (minimum 65%, Missing); tongue: 51.8868% (minimum 70%, Missing); urinary bladder: 57.8947% (minimum 70%, Missing)",-0.259929,-0.301449,-0.534314,0,80,unavailable,20,8.3,8.6,"bone marrow: 20 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 3); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); retina: 4.4 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 3); lung: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); esophagus: 3.3 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175073,VCPIP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 61.1111% (minimum 75%, Baseline (adaptation disabled)); amygdala: 66.2651% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.4762% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 21.5686% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.4762% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 49.1071% (minimum 75%, Baseline (adaptation disabled)); colon: 56.1224% (minimum 70%, Baseline (adaptation disabled)); duodenum: 59.7826% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.5000% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.2651% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.7059% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.2651% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.7010% (minimum 75%, Baseline (adaptation disabled)); liver: 44.7154% (minimum 75%, Baseline (adaptation disabled)); lung: 57.8947% (minimum 75%, Baseline (adaptation disabled)); lymph node: 39.8551% (minimum 70%, Baseline (adaptation disabled)); midbrain: 66.2651% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.5106% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.4587% (minimum 70%, Baseline (adaptation disabled)); rectum: 58.5106% (minimum 70%, Baseline (adaptation disabled)); retina: 55.5556% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 57.2917% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 51.8868% (minimum 75%, Baseline (adaptation disabled)); skin: 63.2184% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.1111% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.2184% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.9012% (minimum 75%, Baseline (adaptation disabled)); spleen: 39.0071% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.5556% (minimum 70%, Baseline (adaptation disabled)); thymus: 51.4019% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.2917% (minimum 65%, Baseline (adaptation disabled)); tongue: 51.8868% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.8947% (minimum 70%, Baseline (adaptation disabled))",-0.259929,-0.301449,-0.534314,0,80,unavailable,20,8.3,8.6,"bone marrow: 20 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 3); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); retina: 4.4 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 3); lung: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); esophagus: 3.3 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175073,VCPIP1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 41.6667% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); kidney: 90.9091% (minimum 99%, Missing); thymus: 0.6784% (minimum 95%, Missing); thyroid gland: 4.1667% (minimum 95%, Missing)",-0.943216,0.03,-0.573333,0,80,unavailable,1.4,0,146.4,"thymus: 146.4 nTPM (manageable, limit 5); thyroid gland: 23 nTPM (manageable, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175097,RAG2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 41.6667% (minimum 75%, Missing); thymus: 0.6784% (minimum 65%, Missing); thyroid gland: 4.1667% (minimum 65%, Missing)",-0.643216,0.3,-0.333333,0,80,unavailable,1.4,0,146.4,"thymus: 146.4 nTPM (manageable, limit 5); thyroid gland: 23 nTPM (manageable, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175097,RAG2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 41.6667% (minimum 75%, Missing); thymus: 0.6784% (minimum 65%, Missing); thyroid gland: 4.1667% (minimum 65%, Missing)",-0.643216,0.3,-0.333333,0,80,unavailable,1.4,0,146.4,"thymus: 146.4 nTPM (manageable, limit 5); thyroid gland: 23 nTPM (manageable, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175097,RAG2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 41.6667% (minimum 75%, Missing); thymus: 0.6784% (minimum 65%, Missing); thyroid gland: 4.1667% (minimum 65%, Missing)",-0.643216,0.3,-0.333333,0,80,unavailable,1.4,0,146.4,"thymus: 146.4 nTPM (manageable, limit 5); thyroid gland: 23 nTPM (manageable, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175097,RAG2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 41.6667% (minimum 75%, Baseline (adaptation disabled)); thymus: 0.6784% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 4.1667% (minimum 65%, Baseline (adaptation disabled))",-0.643216,0.3,-0.333333,0,80,unavailable,1.4,0,146.4,"thymus: 146.4 nTPM (manageable, limit 5); thyroid gland: 23 nTPM (manageable, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175097,RAG2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 69.6721% (minimum 95%, Missing); adrenal gland: 57.0470% (minimum 99%, Uncertain); amygdala: 73.2759% (minimum 99%, Missing); basal ganglia: 74.5614% (minimum 99%, Missing); bone marrow: 44.2708% (minimum 99%, Missing); cerebellum: 68.5484% (minimum 99%, Missing); cerebral cortex: 78.7037% (minimum 99%, Missing); choroid plexus: 56.2914% (minimum 99%, Missing); colon: 72.6496% (minimum 97%, Missing); duodenum: 80.1887% (minimum 99%, Missing); esophagus: 59.8592% (minimum 97%, Missing); heart muscle: 68.5484% (minimum 99%, Missing); hippocampal formation: 70.2479% (minimum 99%, Missing); hypothalamus: 69.6721% (minimum 99%, Missing); kidney: 57.8231% (minimum 99%, Missing); liver: 69.1057% (minimum 99%, Uncertain); lung: 65.8915% (minimum 99%, Missing); lymph node: 75.8929% (minimum 97%, Missing); midbrain: 69.1057% (minimum 99%, Missing); pancreas: 62.9630% (minimum 99%, Missing); parathyroid gland: 70.2479% (minimum 97%, Uncertain); pituitary gland: 46.4481% (minimum 99%, Missing); rectum: 80.9524% (minimum 97%, Missing); retina: 68.0000% (minimum 99%, Missing); salivary gland: 59.4406% (minimum 97%, Missing); skeletal muscle: 74.5614% (minimum 99%, Uncertain); skin: 66.4062% (minimum 95%, Uncertain); small intestine: 69.6721% (minimum 99%, Missing); smooth muscle: 80.1887% (minimum 99%, Missing); spinal cord: 63.4328% (minimum 99%, Missing); spleen: 64.8855% (minimum 95%, Uncertain); stomach: 69.6721% (minimum 97%, Missing); thymus: 82.5243% (minimum 95%, Missing); thyroid gland: 56.2914% (minimum 95%, Missing); tongue: 85.8586% (minimum 97%, Missing); urinary bladder: 69.1057% (minimum 97%, Missing)",-0.387086,-0.375594,-0.547292,0,1,partial,10.7,5.8,6.6,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); salivary gland: 5.8 nTPM (protected, limit 2); esophagus: 5.7 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175106,TVP23C,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 57.0470% (minimum 75%, Uncertain); amygdala: 73.2759% (minimum 75%, Missing); basal ganglia: 74.5614% (minimum 75%, Missing); bone marrow: 44.2708% (minimum 75%, Missing); cerebellum: 68.5484% (minimum 75%, Missing); choroid plexus: 56.2914% (minimum 75%, Missing); esophagus: 59.8592% (minimum 70%, Missing); heart muscle: 68.5484% (minimum 75%, Missing); hippocampal formation: 70.2479% (minimum 75%, Missing); hypothalamus: 69.6721% (minimum 75%, Missing); kidney: 57.8231% (minimum 75%, Missing); liver: 69.1057% (minimum 75%, Uncertain); lung: 65.8915% (minimum 75%, Missing); midbrain: 69.1057% (minimum 75%, Missing); pancreas: 62.9630% (minimum 75%, Missing); pituitary gland: 46.4481% (minimum 75%, Missing); retina: 68.0000% (minimum 75%, Missing); salivary gland: 59.4406% (minimum 70%, Missing); skeletal muscle: 74.5614% (minimum 75%, Uncertain); small intestine: 69.6721% (minimum 75%, Missing); spinal cord: 63.4328% (minimum 75%, Missing); spleen: 64.8855% (minimum 65%, Uncertain); stomach: 69.6721% (minimum 70%, Missing); thyroid gland: 56.2914% (minimum 65%, Missing); urinary bladder: 69.1057% (minimum 70%, Missing)",-0.0870861,-0.105594,-0.307292,0,1,partial,10.7,5.8,6.6,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); salivary gland: 5.8 nTPM (protected, limit 2); esophagus: 5.7 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175106,TVP23C,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 57.0470% (minimum 75%, Uncertain); amygdala: 73.2759% (minimum 75%, Missing); basal ganglia: 74.5614% (minimum 75%, Missing); bone marrow: 44.2708% (minimum 75%, Missing); cerebellum: 68.5484% (minimum 75%, Missing); choroid plexus: 56.2914% (minimum 75%, Missing); esophagus: 59.8592% (minimum 70%, Missing); heart muscle: 68.5484% (minimum 75%, Missing); hippocampal formation: 70.2479% (minimum 75%, Missing); hypothalamus: 69.6721% (minimum 75%, Missing); kidney: 57.8231% (minimum 75%, Missing); liver: 69.1057% (minimum 75%, Uncertain); lung: 65.8915% (minimum 75%, Missing); midbrain: 69.1057% (minimum 75%, Missing); pancreas: 62.9630% (minimum 75%, Missing); pituitary gland: 46.4481% (minimum 75%, Missing); retina: 68.0000% (minimum 75%, Missing); salivary gland: 59.4406% (minimum 70%, Missing); skeletal muscle: 74.5614% (minimum 75%, Uncertain); small intestine: 69.6721% (minimum 75%, Missing); spinal cord: 63.4328% (minimum 75%, Missing); spleen: 64.8855% (minimum 65%, Uncertain); stomach: 69.6721% (minimum 70%, Missing); thyroid gland: 56.2914% (minimum 65%, Missing); urinary bladder: 69.1057% (minimum 70%, Missing)",-0.0870861,-0.105594,-0.307292,0,1,partial,10.7,5.8,6.6,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); salivary gland: 5.8 nTPM (protected, limit 3); esophagus: 5.7 nTPM (protected, limit 3); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); hypothalamus: 3.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175106,TVP23C,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 57.0470% (minimum 75%, Uncertain); amygdala: 73.2759% (minimum 75%, Missing); basal ganglia: 74.5614% (minimum 75%, Missing); bone marrow: 44.2708% (minimum 75%, Missing); cerebellum: 68.5484% (minimum 75%, Missing); choroid plexus: 56.2914% (minimum 75%, Missing); esophagus: 59.8592% (minimum 70%, Missing); heart muscle: 68.5484% (minimum 75%, Missing); hippocampal formation: 70.2479% (minimum 75%, Missing); hypothalamus: 69.6721% (minimum 75%, Missing); kidney: 57.8231% (minimum 75%, Missing); liver: 69.1057% (minimum 75%, Uncertain); lung: 65.8915% (minimum 75%, Missing); midbrain: 69.1057% (minimum 75%, Missing); pancreas: 62.9630% (minimum 75%, Missing); pituitary gland: 46.4481% (minimum 75%, Missing); retina: 68.0000% (minimum 75%, Missing); salivary gland: 59.4406% (minimum 70%, Missing); skeletal muscle: 74.5614% (minimum 75%, Uncertain); small intestine: 69.6721% (minimum 75%, Missing); spinal cord: 63.4328% (minimum 75%, Missing); spleen: 64.8855% (minimum 65%, Uncertain); stomach: 69.6721% (minimum 70%, Missing); thyroid gland: 56.2914% (minimum 65%, Missing); urinary bladder: 69.1057% (minimum 70%, Missing)",-0.0870861,-0.105594,-0.307292,0,1,partial,10.7,5.8,6.6,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); salivary gland: 5.8 nTPM (protected, limit 3); esophagus: 5.7 nTPM (protected, limit 3); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); hypothalamus: 3.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175106,TVP23C,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 57.0470% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.2759% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.5614% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 44.2708% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.5484% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 56.2914% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.8592% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.5484% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.2479% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.6721% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.8231% (minimum 75%, Baseline (adaptation disabled)); liver: 69.1057% (minimum 75%, Baseline (adaptation disabled)); lung: 65.8915% (minimum 75%, Baseline (adaptation disabled)); midbrain: 69.1057% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.9630% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 46.4481% (minimum 75%, Baseline (adaptation disabled)); retina: 68.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.4406% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 74.5614% (minimum 75%, Baseline (adaptation disabled)); small intestine: 69.6721% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.4328% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.8855% (minimum 65%, Baseline (adaptation disabled)); stomach: 69.6721% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 56.2914% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 69.1057% (minimum 70%, Baseline (adaptation disabled))",-0.0870861,-0.105594,-0.307292,0,1,partial,10.7,5.8,6.6,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); salivary gland: 5.8 nTPM (protected, limit 3); esophagus: 5.7 nTPM (protected, limit 3); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); hypothalamus: 3.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175106,TVP23C,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 55.0847% (minimum 99%, Missing); amygdala: 65.0000% (minimum 99%, Missing); basal ganglia: 80.2469% (minimum 99%, Missing); cerebellum: 50.3876% (minimum 99%, Missing); cerebral cortex: 34.9462% (minimum 99%, Missing); choroid plexus: 95.5882% (minimum 99%, Missing); heart muscle: 86.6667% (minimum 98%, Approved); hippocampal formation: 38.6905% (minimum 99%, Missing); hypothalamus: 54.1667% (minimum 99%, Missing); kidney: 90.2778% (minimum 98%, Approved); liver: 86.6667% (minimum 98%, Approved); lung: 97.0149% (minimum 98%, Approved); midbrain: 65.6566% (minimum 99%, Missing); pancreas: 91.5493% (minimum 98%, Approved); parathyroid gland: 95.5882% (minimum 97%, Missing); pituitary gland: 83.3333% (minimum 99%, Missing); retina: 23.1317% (minimum 99%, Missing); small intestine: 97.0149% (minimum 98%, Approved); smooth muscle: 95.5882% (minimum 98%, Approved); spinal cord: 74.7126% (minimum 99%, Missing); stomach: 94.2029% (minimum 95%, Approved)",0.0201493,-0.0141176,-0.758683,0,1,partial,21.6,0.4,0.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175175,PPM1E,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 55.0847% (minimum 75%, Missing); amygdala: 65.0000% (minimum 75%, Missing); cerebellum: 50.3876% (minimum 75%, Missing); cerebral cortex: 34.9462% (minimum 75%, Missing); hippocampal formation: 38.6905% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); midbrain: 65.6566% (minimum 75%, Missing); retina: 23.1317% (minimum 75%, Missing); spinal cord: 74.7126% (minimum 75%, Missing)",0.320149,0.255882,-0.518683,0,1,partial,21.6,0.4,0.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175175,PPM1E,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 55.0847% (minimum 75%, Missing); amygdala: 65.0000% (minimum 75%, Missing); cerebellum: 50.3876% (minimum 75%, Missing); cerebral cortex: 34.9462% (minimum 75%, Missing); hippocampal formation: 38.6905% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); midbrain: 65.6566% (minimum 75%, Missing); retina: 23.1317% (minimum 75%, Missing); spinal cord: 74.7126% (minimum 75%, Missing)",0.320149,0.255882,-0.518683,0,1,partial,21.6,0.4,0.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175175,PPM1E,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 55.0847% (minimum 75%, Missing); amygdala: 65.0000% (minimum 75%, Missing); cerebellum: 50.3876% (minimum 75%, Missing); cerebral cortex: 34.9462% (minimum 75%, Missing); hippocampal formation: 38.6905% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); midbrain: 65.6566% (minimum 75%, Missing); retina: 23.1317% (minimum 75%, Missing); spinal cord: 74.7126% (minimum 75%, Missing)",0.320149,0.255882,-0.518683,0,1,partial,21.6,0.4,0.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175175,PPM1E,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 55.0847% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 50.3876% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 34.9462% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 38.6905% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 54.1667% (minimum 75%, Baseline (adaptation disabled)); midbrain: 65.6566% (minimum 75%, Baseline (adaptation disabled)); retina: 23.1317% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.7126% (minimum 75%, Baseline (adaptation disabled))",0.320149,0.242029,-0.518683,0,1,partial,21.6,0.4,0.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175175,PPM1E,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thyroid gland: 94.5946% (minimum 95%, Missing)",-0.00405405,0.03,0.01,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175202,HIGD2B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.295946,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175202,HIGD2B,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.295946,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175202,HIGD2B,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.295946,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175202,HIGD2B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.295946,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175202,HIGD2B,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.1098% (minimum 99%, Missing); lung: 97.6744% (minimum 99%, Missing)",0.0324561,0.0240828,-0.0189017,0,80,unavailable,0.5,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175294,CATSPER1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.332456,0.294083,0.221098,0,80,unavailable,0.5,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175294,CATSPER1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.332456,0.294083,0.221098,0,80,unavailable,0.5,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175294,CATSPER1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.332456,0.294083,0.221098,0,80,unavailable,0.5,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175294,CATSPER1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.332456,0.294083,0.221098,0,80,unavailable,0.5,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175294,CATSPER1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 87.0370% (minimum 99%, Missing); basal ganglia: 87.0370% (minimum 99%, Missing); bone marrow: 27.8656% (minimum 99%, Missing); cerebellum: 86.5031% (minimum 99%, Missing); cerebral cortex: 65.8879% (minimum 99%, Missing); choroid plexus: 96.5753% (minimum 99%, Missing); colon: 72.6804% (minimum 97%, Missing); duodenum: 80.1136% (minimum 99%, Missing); esophagus: 75.8065% (minimum 97%, Missing); heart muscle: 91.5584% (minimum 95%, Enhanced); hippocampal formation: 77.9006% (minimum 99%, Missing); hypothalamus: 85.4545% (minimum 99%, Missing); liver: 86.5031% (minimum 95%, Enhanced); lung: 89.2405% (minimum 99%, Missing); lymph node: 57.0850% (minimum 97%, Missing); midbrain: 72.3077% (minimum 99%, Missing); pancreas: 89.2405% (minimum 95%, Enhanced); pituitary gland: 95.9184% (minimum 99%, Missing); rectum: 71.9388% (minimum 97%, Missing); retina: 73.8220% (minimum 99%, Missing); skin: 71.2121% (minimum 95%, Missing); small intestine: 77.0492% (minimum 99%, Missing); smooth muscle: 87.0370% (minimum 95%, Enhanced); spinal cord: 44.6203% (minimum 99%, Missing); stomach: 78.3333% (minimum 97%, Missing); thymus: 48.9583% (minimum 95%, Missing); tongue: 95.2703% (minimum 97%, Missing); urinary bladder: 87.5776% (minimum 97%, Missing)",-0.460417,-0.39915,-0.711344,0,1,partial,36.5,10.6,14.7,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 10.6 nTPM (protected, limit 2); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); retina: 5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175305,CCNE2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 27.8656% (minimum 75%, Missing); cerebral cortex: 65.8879% (minimum 75%, Missing); lymph node: 57.0850% (minimum 70%, Missing); midbrain: 72.3077% (minimum 75%, Missing); retina: 73.8220% (minimum 75%, Missing); spinal cord: 44.6203% (minimum 75%, Missing); thymus: 48.9583% (minimum 65%, Missing)",-0.160417,-0.12915,-0.471344,0,1,partial,36.5,10.6,14.7,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 10.6 nTPM (protected, limit 2); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); retina: 5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175305,CCNE2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 27.8656% (minimum 75%, Missing); cerebral cortex: 65.8879% (minimum 75%, Missing); lymph node: 57.0850% (minimum 70%, Missing); midbrain: 72.3077% (minimum 75%, Missing); retina: 73.8220% (minimum 75%, Missing); spinal cord: 44.6203% (minimum 75%, Missing); thymus: 48.9583% (minimum 65%, Missing)",-0.160417,-0.12915,-0.471344,0,1,partial,36.5,10.6,14.7,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 10.6 nTPM (protected, limit 3); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); retina: 5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175305,CCNE2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 27.8656% (minimum 75%, Missing); cerebral cortex: 65.8879% (minimum 75%, Missing); lymph node: 57.0850% (minimum 70%, Missing); midbrain: 72.3077% (minimum 75%, Missing); retina: 73.8220% (minimum 75%, Missing); spinal cord: 44.6203% (minimum 75%, Missing); thymus: 48.9583% (minimum 65%, Missing)",-0.160417,-0.12915,-0.471344,0,1,partial,36.5,10.6,14.7,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 10.6 nTPM (protected, limit 3); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); retina: 5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175305,CCNE2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 27.8656% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.8879% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.0850% (minimum 70%, Baseline (adaptation disabled)); midbrain: 72.3077% (minimum 75%, Baseline (adaptation disabled)); retina: 73.8220% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 44.6203% (minimum 75%, Baseline (adaptation disabled)); thymus: 48.9583% (minimum 65%, Baseline (adaptation disabled))",-0.160417,-0.12915,-0.471344,0,1,partial,36.5,10.6,14.7,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 10.6 nTPM (protected, limit 3); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); retina: 5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175305,CCNE2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 24.2424% (minimum 99%, Missing); amygdala: 70.5882% (minimum 99%, Missing); basal ganglia: 82.7586% (minimum 99%, Missing); bone marrow: 72.7273% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 99%, Missing); cerebral cortex: 58.5366% (minimum 99%, Missing); choroid plexus: 38.7097% (minimum 99%, Missing); colon: 63.1579% (minimum 97%, Missing); duodenum: 35.8209% (minimum 99%, Missing); esophagus: 92.3077% (minimum 97%, Missing); heart muscle: 85.7143% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 55.8140% (minimum 99%, Missing); kidney: 85.7143% (minimum 99%, Missing); liver: 96.0000% (minimum 99%, Missing); lung: 82.7586% (minimum 95%, Enhanced); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 51.0638% (minimum 99%, Missing); parathyroid gland: 27.9070% (minimum 97%, Missing); pituitary gland: 70.5882% (minimum 99%, Missing); rectum: 52.1739% (minimum 97%, Missing); retina: 48.9796% (minimum 99%, Missing); salivary gland: 82.7586% (minimum 97%, Missing); skeletal muscle: 85.7143% (minimum 99%, Missing); skin: 88.8889% (minimum 95%, Missing); small intestine: 20.3390% (minimum 99%, Missing); smooth muscle: 85.7143% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 27.2727% (minimum 97%, Missing); thymus: 85.7143% (minimum 95%, Missing); thyroid gland: 53.3333% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 63.1579% (minimum 97%, Missing)",-0.416667,-0.697273,-0.78661,0,8,partial,9.4,6.4,2.1,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 2); parathyroid gland: 6.2 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175344,CHRNA7,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 24.2424% (minimum 75%, Missing); amygdala: 70.5882% (minimum 75%, Missing); bone marrow: 72.7273% (minimum 75%, Missing); cerebral cortex: 58.5366% (minimum 75%, Missing); choroid plexus: 38.7097% (minimum 75%, Missing); colon: 63.1579% (minimum 70%, Missing); duodenum: 35.8209% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); hypothalamus: 55.8140% (minimum 75%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pancreas: 51.0638% (minimum 75%, Missing); parathyroid gland: 27.9070% (minimum 70%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); rectum: 52.1739% (minimum 70%, Missing); retina: 48.9796% (minimum 75%, Missing); small intestine: 20.3390% (minimum 75%, Missing); stomach: 27.2727% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.116667,-0.427273,-0.54661,0,8,partial,9.4,6.4,2.1,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 2); parathyroid gland: 6.2 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175344,CHRNA7,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 24.2424% (minimum 75%, Missing); amygdala: 70.5882% (minimum 75%, Missing); bone marrow: 72.7273% (minimum 75%, Missing); cerebral cortex: 58.5366% (minimum 75%, Missing); choroid plexus: 38.7097% (minimum 75%, Missing); colon: 63.1579% (minimum 70%, Missing); duodenum: 35.8209% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); hypothalamus: 55.8140% (minimum 75%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pancreas: 51.0638% (minimum 75%, Missing); parathyroid gland: 27.9070% (minimum 70%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); rectum: 52.1739% (minimum 70%, Missing); retina: 48.9796% (minimum 75%, Missing); small intestine: 20.3390% (minimum 75%, Missing); stomach: 27.2727% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.116667,-0.427273,-0.54661,0,8,partial,9.4,6.4,2.1,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 3); parathyroid gland: 6.2 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175344,CHRNA7,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 24.2424% (minimum 75%, Missing); amygdala: 70.5882% (minimum 75%, Missing); bone marrow: 72.7273% (minimum 75%, Missing); cerebral cortex: 58.5366% (minimum 75%, Missing); choroid plexus: 38.7097% (minimum 75%, Missing); colon: 63.1579% (minimum 70%, Missing); duodenum: 35.8209% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); hypothalamus: 55.8140% (minimum 75%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pancreas: 51.0638% (minimum 75%, Missing); parathyroid gland: 27.9070% (minimum 70%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); rectum: 52.1739% (minimum 70%, Missing); retina: 48.9796% (minimum 75%, Missing); small intestine: 20.3390% (minimum 75%, Missing); stomach: 27.2727% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.116667,-0.427273,-0.54661,0,8,partial,9.4,6.4,2.1,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 3); parathyroid gland: 6.2 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175344,CHRNA7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 24.2424% (minimum 75%, Baseline (adaptation disabled)); amygdala: 70.5882% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 72.7273% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.5366% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 38.7097% (minimum 75%, Baseline (adaptation disabled)); colon: 63.1579% (minimum 70%, Baseline (adaptation disabled)); duodenum: 35.8209% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.8140% (minimum 75%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 51.0638% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 27.9070% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.5882% (minimum 75%, Baseline (adaptation disabled)); rectum: 52.1739% (minimum 70%, Baseline (adaptation disabled)); retina: 48.9796% (minimum 75%, Baseline (adaptation disabled)); small intestine: 20.3390% (minimum 75%, Baseline (adaptation disabled)); stomach: 27.2727% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.3333% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 63.1579% (minimum 70%, Baseline (adaptation disabled))",-0.116667,-0.427273,-0.54661,0,8,partial,9.4,6.4,2.1,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 3); parathyroid gland: 6.2 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175344,CHRNA7,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Uncertain); adrenal gland: 84.3972% (minimum 99%, Missing); amygdala: 88.1481% (minimum 99%, Missing); basal ganglia: 82.0690% (minimum 99%, Missing); bone marrow: 40.3390% (minimum 99%, Uncertain); cerebellum: 80.9524% (minimum 99%, Missing); cerebral cortex: 88.1481% (minimum 99%, Missing); choroid plexus: 85.0000% (minimum 99%, Missing); colon: 86.8613% (minimum 97%, Missing); duodenum: 95.2000% (minimum 99%, Missing); esophagus: 87.5000% (minimum 97%, Missing); heart muscle: 77.7778% (minimum 99%, Missing); hippocampal formation: 88.1481% (minimum 99%, Missing); hypothalamus: 86.2319% (minimum 99%, Missing); kidney: 83.2168% (minimum 99%, Missing); liver: 84.3972% (minimum 99%, Missing); lung: 89.4737% (minimum 99%, Missing); lymph node: 86.8613% (minimum 97%, Missing); midbrain: 84.3972% (minimum 99%, Missing); pancreas: 77.2727% (minimum 99%, Missing); parathyroid gland: 83.2168% (minimum 97%, Missing); pituitary gland: 81.5068% (minimum 99%, Missing); rectum: 92.2481% (minimum 97%, Missing); retina: 83.8028% (minimum 99%, Missing); salivary gland: 80.4054% (minimum 97%, Missing); skeletal muscle: 72.1212% (minimum 99%, Missing); skin: 71.6867% (minimum 95%, Missing); small intestine: 91.5385% (minimum 99%, Missing); smooth muscle: 95.9677% (minimum 99%, Missing); spinal cord: 82.6389% (minimum 99%, Missing); spleen: 83.8028% (minimum 95%, Missing); stomach: 83.2168% (minimum 97%, Missing); thymus: 80.9524% (minimum 95%, Missing); thyroid gland: 86.8613% (minimum 95%, Missing); tongue: 80.9524% (minimum 97%, Missing); urinary bladder: 84.3972% (minimum 97%, Missing)",-0.233133,-0.165946,-0.58661,0,1,partial,17.6,2.9,4.7,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); cerebellum: 2.8 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175449,RFESD,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 40.3390% (minimum 75%, Uncertain); skeletal muscle: 72.1212% (minimum 75%, Missing)",0.0668675,0.104054,-0.34661,0,1,partial,17.6,2.9,4.7,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); cerebellum: 2.8 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175449,RFESD,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 40.3390% (minimum 75%, Uncertain); skeletal muscle: 72.1212% (minimum 75%, Missing)",0.0668675,0.104054,-0.34661,0,1,partial,17.6,2.9,4.7,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175449,RFESD,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 40.3390% (minimum 75%, Uncertain); skeletal muscle: 72.1212% (minimum 75%, Missing)",0.0668675,0.104054,-0.34661,0,1,partial,17.6,2.9,4.7,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175449,RFESD,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 40.3390% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 72.1212% (minimum 75%, Baseline (adaptation disabled))",0.0668675,0.104054,-0.34661,0,1,partial,17.6,2.9,4.7,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175449,RFESD,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 93.2692% (minimum 99%, Missing); hypothalamus: 95.0980% (minimum 99%, Missing); spinal cord: 98.9796% (minimum 99%, Missing)",0.029798,0.03,-0.0573077,0,80,unavailable,0.7,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175513,TSGA10IP,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.329798,0.3,0.182692,0,80,unavailable,0.7,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175513,TSGA10IP,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.329798,0.3,0.182692,0,80,unavailable,0.7,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175513,TSGA10IP,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.329798,0.3,0.182692,0,80,unavailable,0.7,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175513,TSGA10IP,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.329798,0.3,0.182692,0,80,unavailable,0.7,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175513,TSGA10IP,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7848% (minimum 99%, Missing); heart muscle: 98.0952% (minimum 99%, Missing); kidney: 95.9627% (minimum 99%, Missing); liver: 97.1698% (minimum 99%, Missing); lung: 97.4763% (minimum 99%, Missing); pancreas: 98.0952% (minimum 99%, Missing); pituitary gland: 98.4076% (minimum 99%, Missing); small intestine: 97.4763% (minimum 99%, Missing)",0.00665635,0.0078481,-0.0303727,0,80,unavailable,1.3,0.7,1.4,"kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175518,UBQLNL,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.306656,0.277848,0.209627,0,80,unavailable,1.3,0.7,1.4,"kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175518,UBQLNL,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.306656,0.277848,0.209627,0,80,unavailable,1.3,0.7,1.4,"kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175518,UBQLNL,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.306656,0.277848,0.209627,0,80,unavailable,1.3,0.7,1.4,"kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175518,UBQLNL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.306656,0.277848,0.209627,0,80,unavailable,1.3,0.7,1.4,"kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175518,UBQLNL,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175520,UBQLN3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175520,UBQLN3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175520,UBQLN3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175520,UBQLN3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175520,UBQLN3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.2256% (minimum 95%, Missing); adrenal gland: 86.3309% (minimum 99%, Missing); amygdala: 91.6031% (minimum 99%, Missing); basal ganglia: 90.2256% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 99%, Missing); cerebellum: 93.7500% (minimum 99%, Missing); cerebral cortex: 91.6031% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 85.7143% (minimum 97%, Missing); duodenum: 76.9231% (minimum 99%, Missing); esophagus: 86.9565% (minimum 97%, Missing); heart muscle: 89.5522% (minimum 99%, Missing); hippocampal formation: 91.6031% (minimum 99%, Missing); hypothalamus: 91.6031% (minimum 99%, Missing); kidney: 73.1707% (minimum 99%, Missing); liver: 79.4702% (minimum 99%, Missing); lung: 87.5912% (minimum 99%, Missing); lymph node: 85.1064% (minimum 97%, Missing); midbrain: 91.6031% (minimum 99%, Missing); pancreas: 81.0811% (minimum 99%, Missing); parathyroid gland: 85.7143% (minimum 97%, Missing); pituitary gland: 85.1064% (minimum 99%, Missing); rectum: 84.5070% (minimum 97%, Missing); retina: 86.3309% (minimum 99%, Missing); salivary gland: 85.7143% (minimum 97%, Missing); skeletal muscle: 60.6061% (minimum 99%, Missing); skin: 88.2353% (minimum 95%, Missing); small intestine: 77.4194% (minimum 99%, Missing); smooth muscle: 96.0000% (minimum 99%, Missing); spinal cord: 89.5522% (minimum 99%, Missing); spleen: 85.7143% (minimum 90%, Approved); stomach: 77.9221% (minimum 97%, Missing); thymus: 81.6327% (minimum 95%, Missing); thyroid gland: 80.5369% (minimum 95%, Missing); tongue: 63.8298% (minimum 97%, Missing); urinary bladder: 87.5912% (minimum 97%, Missing)",-0.144631,-0.331702,-0.383939,0,9,partial,7.8,6.8,2.9,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 2); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175536,LIPT2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 73.1707% (minimum 75%, Missing); skeletal muscle: 60.6061% (minimum 75%, Missing); tongue: 63.8298% (minimum 70%, Missing)",0.155369,-0.0617021,-0.143939,0,9,partial,7.8,6.8,2.9,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 2); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175536,LIPT2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 73.1707% (minimum 75%, Missing); skeletal muscle: 60.6061% (minimum 75%, Missing); tongue: 63.8298% (minimum 70%, Missing)",0.155369,-0.0617021,-0.143939,0,9,partial,7.8,6.8,2.9,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175536,LIPT2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 73.1707% (minimum 75%, Missing); skeletal muscle: 60.6061% (minimum 75%, Missing); tongue: 63.8298% (minimum 70%, Missing)",0.155369,-0.0617021,-0.143939,0,9,partial,7.8,6.8,2.9,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175536,LIPT2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 73.1707% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 60.6061% (minimum 75%, Baseline (adaptation disabled)); tongue: 63.8298% (minimum 70%, Baseline (adaptation disabled))",0.155369,-0.0617021,-0.143939,0,9,partial,7.8,6.8,2.9,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175536,LIPT2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9351% (minimum 90%, Approved); adrenal gland: 59.5238% (minimum 99%, Missing); amygdala: 84.7458% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 54.3478% (minimum 99%, Missing); cerebellum: 79.3651% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 87.7193% (minimum 99%, Missing); colon: 71.4286% (minimum 97%, Missing); duodenum: 67.5676% (minimum 99%, Missing); esophagus: 74.6269% (minimum 97%, Missing); heart muscle: 70.4225% (minimum 99%, Missing); hippocampal formation: 86.2069% (minimum 99%, Missing); hypothalamus: 87.7193% (minimum 99%, Missing); kidney: 61.7284% (minimum 99%, Missing); liver: 58.1395% (minimum 99%, Missing); lung: 67.5676% (minimum 99%, Missing); lymph node: 52.6316% (minimum 97%, Missing); midbrain: 86.2069% (minimum 99%, Missing); pancreas: 64.1026% (minimum 99%, Missing); parathyroid gland: 58.8235% (minimum 97%, Missing); pituitary gland: 81.9672% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 36.2319% (minimum 99%, Missing); salivary gland: 64.9351% (minimum 97%, Missing); skeletal muscle: 78.1250% (minimum 99%, Missing); skin: 54.3478% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); smooth muscle: 67.5676% (minimum 99%, Missing); spinal cord: 81.9672% (minimum 99%, Missing); spleen: 52.6316% (minimum 95%, Missing); stomach: 58.1395% (minimum 97%, Missing); thymus: 56.1798% (minimum 95%, Missing); thyroid gland: 55.5556% (minimum 95%, Missing); tongue: 68.4932% (minimum 97%, Missing); urinary bladder: 78.1250% (minimum 97%, Missing)",-0.423684,-0.443684,-0.627681,0,1,partial,8.8,4.5,4.5,"retina: 8.8 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175548,ALG10B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 59.5238% (minimum 75%, Missing); bone marrow: 54.3478% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); duodenum: 67.5676% (minimum 75%, Missing); heart muscle: 70.4225% (minimum 75%, Missing); kidney: 61.7284% (minimum 75%, Missing); liver: 58.1395% (minimum 75%, Missing); lung: 67.5676% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); pancreas: 64.1026% (minimum 75%, Missing); parathyroid gland: 58.8235% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 36.2319% (minimum 75%, Missing); salivary gland: 64.9351% (minimum 70%, Missing); skin: 54.3478% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); smooth muscle: 67.5676% (minimum 75%, Missing); spleen: 52.6316% (minimum 65%, Missing); stomach: 58.1395% (minimum 70%, Missing); thymus: 56.1798% (minimum 65%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing); tongue: 68.4932% (minimum 70%, Missing)",-0.123684,-0.173684,-0.387681,0,1,partial,8.8,4.5,4.5,"retina: 8.8 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175548,ALG10B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 59.5238% (minimum 75%, Missing); bone marrow: 54.3478% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); duodenum: 67.5676% (minimum 75%, Missing); heart muscle: 70.4225% (minimum 75%, Missing); kidney: 61.7284% (minimum 75%, Missing); liver: 58.1395% (minimum 75%, Missing); lung: 67.5676% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); pancreas: 64.1026% (minimum 75%, Missing); parathyroid gland: 58.8235% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 36.2319% (minimum 75%, Missing); salivary gland: 64.9351% (minimum 70%, Missing); skin: 54.3478% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); smooth muscle: 67.5676% (minimum 75%, Missing); spleen: 52.6316% (minimum 65%, Missing); stomach: 58.1395% (minimum 70%, Missing); thymus: 56.1798% (minimum 65%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing); tongue: 68.4932% (minimum 70%, Missing)",-0.123684,-0.173684,-0.387681,0,1,partial,8.8,4.5,4.5,"retina: 8.8 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175548,ALG10B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 59.5238% (minimum 75%, Missing); bone marrow: 54.3478% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); duodenum: 67.5676% (minimum 75%, Missing); heart muscle: 70.4225% (minimum 75%, Missing); kidney: 61.7284% (minimum 75%, Missing); liver: 58.1395% (minimum 75%, Missing); lung: 67.5676% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); pancreas: 64.1026% (minimum 75%, Missing); parathyroid gland: 58.8235% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 36.2319% (minimum 75%, Missing); salivary gland: 64.9351% (minimum 70%, Missing); skin: 54.3478% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); smooth muscle: 67.5676% (minimum 75%, Missing); spleen: 52.6316% (minimum 65%, Missing); stomach: 58.1395% (minimum 70%, Missing); thymus: 56.1798% (minimum 65%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing); tongue: 68.4932% (minimum 70%, Missing)",-0.123684,-0.173684,-0.387681,0,1,partial,8.8,4.5,4.5,"retina: 8.8 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175548,ALG10B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9351% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 59.5238% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 54.3478% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); duodenum: 67.5676% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.4225% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.7284% (minimum 75%, Baseline (adaptation disabled)); liver: 58.1395% (minimum 75%, Baseline (adaptation disabled)); lung: 67.5676% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.6316% (minimum 70%, Baseline (adaptation disabled)); pancreas: 64.1026% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.8235% (minimum 70%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 36.2319% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.9351% (minimum 70%, Baseline (adaptation disabled)); skin: 54.3478% (minimum 65%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.5676% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.6316% (minimum 65%, Baseline (adaptation disabled)); stomach: 58.1395% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.1798% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.5556% (minimum 65%, Baseline (adaptation disabled)); tongue: 68.4932% (minimum 70%, Baseline (adaptation disabled))",-0.123684,-0.173684,-0.387681,0,1,partial,8.8,4.5,4.5,"retina: 8.8 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175548,ALG10B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.05,0.03,0.00986156,0,1,partial,5.6,2.3,4.2,"pituitary gland: 1.9 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175646,PRM1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.249862,0,1,partial,5.6,2.3,4.2,"pituitary gland: 1.9 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175646,PRM1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.249862,0,1,partial,5.6,2.3,4.2,"pituitary gland: 1.9 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175646,PRM1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.249862,0,1,partial,5.6,2.3,4.2,"pituitary gland: 1.9 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175646,PRM1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349694,0.299832,0.249592,0,1,partial,5.6,2.3,4.2,"skeletal muscle: 5.6 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175646,PRM1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.1221% (minimum 99%, Missing); amygdala: 95.8716% (minimum 99%, Missing); basal ganglia: 93.3036% (minimum 99%, Missing); cerebral cortex: 96.3134% (minimum 99%, Missing); choroid plexus: 64.3077% (minimum 99%, Missing); hippocampal formation: 95.0000% (minimum 99%, Missing); hypothalamus: 86.0082% (minimum 99%, Missing); midbrain: 96.7593% (minimum 99%, Missing); pituitary gland: 94.5701% (minimum 99%, Missing); spinal cord: 96.7593% (minimum 99%, Missing)",0.0452381,0.03,-0.346923,0,80,unavailable,11.6,0,0.1,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175664,TEX26,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 64.3077% (minimum 75%, Missing)",0.345238,0.3,-0.106923,0,80,unavailable,11.6,0,0.1,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175664,TEX26,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 64.3077% (minimum 75%, Missing)",0.345238,0.3,-0.106923,0,80,unavailable,11.6,0,0.1,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175664,TEX26,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 64.3077% (minimum 75%, Missing)",0.345238,0.3,-0.106923,0,80,unavailable,11.6,0,0.1,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175664,TEX26,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 64.3077% (minimum 75%, Baseline (adaptation disabled))",0.345238,0.3,-0.106923,0,80,unavailable,11.6,0,0.1,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175664,TEX26,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"heart muscle: 92.8571% (minimum 99%, Missing); skeletal muscle: 88.6364% (minimum 99%, Missing); tongue: 92.8571% (minimum 97%, Missing)",0.05,-0.0414286,-0.103636,0,80,unavailable,1,0.6,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000175699,CCDC197,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.228571,0.136364,0,80,unavailable,1,0.6,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000175699,CCDC197,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.228571,0.136364,0,80,unavailable,1,0.6,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000175699,CCDC197,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.228571,0.136364,0,80,unavailable,1,0.6,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000175699,CCDC197,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.228571,0.136364,0,80,unavailable,1,0.6,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000175699,CCDC197,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175718,RBMXL3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175718,RBMXL3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175718,RBMXL3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175718,RBMXL3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175718,RBMXL3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.1592% (minimum 90%, Approved); adrenal gland: 69.0058% (minimum 99%, Missing); amygdala: 57.5610% (minimum 99%, Missing); basal ganglia: 58.7065% (minimum 99%, Missing); bone marrow: 88.7218% (minimum 99%, Missing); cerebellum: 65.9218% (minimum 99%, Missing); cerebral cortex: 52.6786% (minimum 99%, Missing); choroid plexus: 70.2381% (minimum 99%, Missing); colon: 54.3779% (minimum 97%, Missing); duodenum: 82.5175% (minimum 99%, Missing); esophagus: 63.1016% (minimum 97%, Missing); heart muscle: 70.2381% (minimum 99%, Missing); hippocampal formation: 51.3043% (minimum 99%, Missing); hypothalamus: 62.7660% (minimum 99%, Missing); kidney: 80.2721% (minimum 99%, Missing); liver: 69.4118% (minimum 99%, Missing); lung: 75.1592% (minimum 98%, Approved); lymph node: 82.5175% (minimum 95%, Approved); midbrain: 47.3896% (minimum 99%, Missing); pancreas: 70.2381% (minimum 99%, Missing); parathyroid gland: 72.3926% (minimum 95%, Approved); pituitary gland: 80.2721% (minimum 99%, Missing); rectum: 74.6835% (minimum 97%, Missing); retina: 64.1304% (minimum 99%, Missing); salivary gland: 71.0843% (minimum 97%, Missing); skeletal muscle: 30.8094% (minimum 99%, Missing); skin: 72.3926% (minimum 95%, Missing); small intestine: 79.1946% (minimum 99%, Missing); smooth muscle: 55.6604% (minimum 99%, Missing); spinal cord: 35.1190% (minimum 99%, Missing); spleen: 77.1242% (minimum 95%, Missing); stomach: 74.2138% (minimum 97%, Missing); thymus: 80.8219% (minimum 95%, Missing); thyroid gland: 77.6316% (minimum 95%, Missing); tongue: 58.1281% (minimum 97%, Missing); urinary bladder: 68.2081% (minimum 97%, Missing)",-0.226074,-0.426221,-0.681906,0,2,partial,26.5,9.9,4.5,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 2); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 2); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 2); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 4); stomach: 4.1 nTPM (protected, limit 2); rectum: 4 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 2); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175764,TTLL11,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0058% (minimum 75%, Missing); amygdala: 57.5610% (minimum 75%, Missing); basal ganglia: 58.7065% (minimum 75%, Missing); cerebellum: 65.9218% (minimum 75%, Missing); cerebral cortex: 52.6786% (minimum 75%, Missing); choroid plexus: 70.2381% (minimum 75%, Missing); colon: 54.3779% (minimum 70%, Missing); esophagus: 63.1016% (minimum 70%, Missing); heart muscle: 70.2381% (minimum 75%, Missing); hippocampal formation: 51.3043% (minimum 75%, Missing); hypothalamus: 62.7660% (minimum 75%, Missing); liver: 69.4118% (minimum 75%, Missing); midbrain: 47.3896% (minimum 75%, Missing); pancreas: 70.2381% (minimum 75%, Missing); retina: 64.1304% (minimum 75%, Missing); skeletal muscle: 30.8094% (minimum 75%, Missing); smooth muscle: 55.6604% (minimum 75%, Missing); spinal cord: 35.1190% (minimum 75%, Missing); tongue: 58.1281% (minimum 70%, Missing); urinary bladder: 68.2081% (minimum 70%, Missing)",0.0739264,-0.156221,-0.441906,0,2,partial,26.5,9.9,4.5,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 2); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 2); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 2); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 4); stomach: 4.1 nTPM (protected, limit 2); rectum: 4 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 2); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175764,TTLL11,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0058% (minimum 75%, Missing); amygdala: 57.5610% (minimum 75%, Missing); basal ganglia: 58.7065% (minimum 75%, Missing); cerebellum: 65.9218% (minimum 75%, Missing); cerebral cortex: 52.6786% (minimum 75%, Missing); choroid plexus: 70.2381% (minimum 75%, Missing); colon: 54.3779% (minimum 70%, Missing); esophagus: 63.1016% (minimum 70%, Missing); heart muscle: 70.2381% (minimum 75%, Missing); hippocampal formation: 51.3043% (minimum 75%, Missing); hypothalamus: 62.7660% (minimum 75%, Missing); liver: 69.4118% (minimum 75%, Missing); midbrain: 47.3896% (minimum 75%, Missing); pancreas: 70.2381% (minimum 75%, Missing); retina: 64.1304% (minimum 75%, Missing); skeletal muscle: 30.8094% (minimum 75%, Missing); smooth muscle: 55.6604% (minimum 75%, Missing); spinal cord: 35.1190% (minimum 75%, Missing); tongue: 58.1281% (minimum 70%, Missing); urinary bladder: 68.2081% (minimum 70%, Missing)",0.0739264,-0.156221,-0.441906,0,2,partial,26.5,9.9,4.5,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 3); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 3); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 3); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 4); stomach: 4.1 nTPM (protected, limit 3); rectum: 4 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 2); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175764,TTLL11,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0058% (minimum 75%, Missing); amygdala: 57.5610% (minimum 75%, Missing); basal ganglia: 58.7065% (minimum 75%, Missing); cerebellum: 65.9218% (minimum 75%, Missing); cerebral cortex: 52.6786% (minimum 75%, Missing); choroid plexus: 70.2381% (minimum 75%, Missing); colon: 54.3779% (minimum 70%, Missing); esophagus: 63.1016% (minimum 70%, Missing); heart muscle: 70.2381% (minimum 75%, Missing); hippocampal formation: 51.3043% (minimum 75%, Missing); hypothalamus: 62.7660% (minimum 75%, Missing); liver: 69.4118% (minimum 75%, Missing); midbrain: 47.3896% (minimum 75%, Missing); pancreas: 70.2381% (minimum 75%, Missing); retina: 64.1304% (minimum 75%, Missing); skeletal muscle: 30.8094% (minimum 75%, Missing); smooth muscle: 55.6604% (minimum 75%, Missing); spinal cord: 35.1190% (minimum 75%, Missing); tongue: 58.1281% (minimum 70%, Missing); urinary bladder: 68.2081% (minimum 70%, Missing)",0.0739264,-0.156221,-0.441906,0,2,partial,26.5,9.9,4.5,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 3); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 3); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 3); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 4); stomach: 4.1 nTPM (protected, limit 3); rectum: 4 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 2); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175764,TTLL11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0058% (minimum 75%, Baseline (adaptation disabled)); amygdala: 57.5610% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.7065% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.9218% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 52.6786% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.2381% (minimum 75%, Baseline (adaptation disabled)); colon: 54.3779% (minimum 70%, Baseline (adaptation disabled)); esophagus: 63.1016% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.2381% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 51.3043% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.7660% (minimum 75%, Baseline (adaptation disabled)); liver: 69.4118% (minimum 75%, Baseline (adaptation disabled)); midbrain: 47.3896% (minimum 75%, Baseline (adaptation disabled)); pancreas: 70.2381% (minimum 75%, Baseline (adaptation disabled)); retina: 64.1304% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 30.8094% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.6604% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 35.1190% (minimum 75%, Baseline (adaptation disabled)); tongue: 58.1281% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 68.2081% (minimum 70%, Baseline (adaptation disabled))",0.0739264,-0.156221,-0.441906,0,2,partial,26.5,9.9,4.5,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 3); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 3); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 3); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 3); stomach: 4.1 nTPM (protected, limit 3); rectum: 4 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175764,TTLL11,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1975% (minimum 95%, Missing); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 59.7701% (minimum 99%, Missing); basal ganglia: 56.5217% (minimum 99%, Missing); bone marrow: 63.4146% (minimum 99%, Missing); cerebellum: 46.8468% (minimum 99%, Missing); cerebral cortex: 49.0566% (minimum 99%, Missing); choroid plexus: 73.2394% (minimum 99%, Missing); colon: 55.3191% (minimum 97%, Missing); duodenum: 65.0000% (minimum 99%, Missing); esophagus: 67.5325% (minimum 97%, Missing); heart muscle: 67.5325% (minimum 99%, Missing); hippocampal formation: 52.5253% (minimum 99%, Missing); hypothalamus: 62.6506% (minimum 99%, Missing); kidney: 59.0909% (minimum 99%, Missing); liver: 71.2329% (minimum 99%, Missing); lung: 62.6506% (minimum 99%, Missing); lymph node: 47.2727% (minimum 97%, Missing); midbrain: 62.6506% (minimum 99%, Missing); pancreas: 61.9048% (minimum 99%, Missing); parathyroid gland: 70.2703% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 50.0000% (minimum 97%, Missing); retina: 57.1429% (minimum 99%, Missing); salivary gland: 57.7778% (minimum 97%, Missing); skeletal muscle: 56.5217% (minimum 99%, Missing); skin: 51.4851% (minimum 95%, Missing); small intestine: 48.5981% (minimum 99%, Missing); smooth muscle: 65.8228% (minimum 99%, Missing); spinal cord: 59.7701% (minimum 99%, Missing); spleen: 46.8468% (minimum 95%, Missing); stomach: 57.1429% (minimum 97%, Missing); thymus: 59.0909% (minimum 95%, Missing); thyroid gland: 52.5253% (minimum 95%, Missing); tongue: 75.3623% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",-0.481532,-0.497273,-0.521532,0,3,partial,5.9,5.8,5.9,"spleen: 5.9 nTPM (manageable, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 2); hippocampal formation: 4.7 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); skeletal muscle: 4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); salivary gland: 3.8 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175787,ZNF169,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1975% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 59.7701% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); bone marrow: 63.4146% (minimum 75%, Missing); cerebellum: 46.8468% (minimum 75%, Missing); cerebral cortex: 49.0566% (minimum 75%, Missing); choroid plexus: 73.2394% (minimum 75%, Missing); colon: 55.3191% (minimum 70%, Missing); duodenum: 65.0000% (minimum 75%, Missing); esophagus: 67.5325% (minimum 70%, Missing); heart muscle: 67.5325% (minimum 75%, Missing); hippocampal formation: 52.5253% (minimum 75%, Missing); hypothalamus: 62.6506% (minimum 75%, Missing); kidney: 59.0909% (minimum 75%, Missing); liver: 71.2329% (minimum 75%, Missing); lung: 62.6506% (minimum 75%, Missing); lymph node: 47.2727% (minimum 70%, Missing); midbrain: 62.6506% (minimum 75%, Missing); pancreas: 61.9048% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); salivary gland: 57.7778% (minimum 70%, Missing); skeletal muscle: 56.5217% (minimum 75%, Missing); skin: 51.4851% (minimum 65%, Missing); small intestine: 48.5981% (minimum 75%, Missing); smooth muscle: 65.8228% (minimum 75%, Missing); spinal cord: 59.7701% (minimum 75%, Missing); spleen: 46.8468% (minimum 65%, Missing); stomach: 57.1429% (minimum 70%, Missing); thymus: 59.0909% (minimum 65%, Missing); thyroid gland: 52.5253% (minimum 65%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.181532,-0.227273,-0.281532,0,3,partial,5.9,5.8,5.9,"spleen: 5.9 nTPM (manageable, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 2); hippocampal formation: 4.7 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); skeletal muscle: 4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); salivary gland: 3.8 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175787,ZNF169,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1975% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 59.7701% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); bone marrow: 63.4146% (minimum 75%, Missing); cerebellum: 46.8468% (minimum 75%, Missing); cerebral cortex: 49.0566% (minimum 75%, Missing); choroid plexus: 73.2394% (minimum 75%, Missing); colon: 55.3191% (minimum 70%, Missing); duodenum: 65.0000% (minimum 75%, Missing); esophagus: 67.5325% (minimum 70%, Missing); heart muscle: 67.5325% (minimum 75%, Missing); hippocampal formation: 52.5253% (minimum 75%, Missing); hypothalamus: 62.6506% (minimum 75%, Missing); kidney: 59.0909% (minimum 75%, Missing); liver: 71.2329% (minimum 75%, Missing); lung: 62.6506% (minimum 75%, Missing); lymph node: 47.2727% (minimum 70%, Missing); midbrain: 62.6506% (minimum 75%, Missing); pancreas: 61.9048% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); salivary gland: 57.7778% (minimum 70%, Missing); skeletal muscle: 56.5217% (minimum 75%, Missing); skin: 51.4851% (minimum 65%, Missing); small intestine: 48.5981% (minimum 75%, Missing); smooth muscle: 65.8228% (minimum 75%, Missing); spinal cord: 59.7701% (minimum 75%, Missing); spleen: 46.8468% (minimum 65%, Missing); stomach: 57.1429% (minimum 70%, Missing); thymus: 59.0909% (minimum 65%, Missing); thyroid gland: 52.5253% (minimum 65%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.181532,-0.227273,-0.281532,0,3,partial,5.9,5.8,5.9,"cerebellum: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 3); hippocampal formation: 4.7 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); skeletal muscle: 4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); salivary gland: 3.8 nTPM (protected, limit 3); kidney: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175787,ZNF169,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1975% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 59.7701% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); bone marrow: 63.4146% (minimum 75%, Missing); cerebellum: 46.8468% (minimum 75%, Missing); cerebral cortex: 49.0566% (minimum 75%, Missing); choroid plexus: 73.2394% (minimum 75%, Missing); colon: 55.3191% (minimum 70%, Missing); duodenum: 65.0000% (minimum 75%, Missing); esophagus: 67.5325% (minimum 70%, Missing); heart muscle: 67.5325% (minimum 75%, Missing); hippocampal formation: 52.5253% (minimum 75%, Missing); hypothalamus: 62.6506% (minimum 75%, Missing); kidney: 59.0909% (minimum 75%, Missing); liver: 71.2329% (minimum 75%, Missing); lung: 62.6506% (minimum 75%, Missing); lymph node: 47.2727% (minimum 70%, Missing); midbrain: 62.6506% (minimum 75%, Missing); pancreas: 61.9048% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); salivary gland: 57.7778% (minimum 70%, Missing); skeletal muscle: 56.5217% (minimum 75%, Missing); skin: 51.4851% (minimum 65%, Missing); small intestine: 48.5981% (minimum 75%, Missing); smooth muscle: 65.8228% (minimum 75%, Missing); spinal cord: 59.7701% (minimum 75%, Missing); spleen: 46.8468% (minimum 65%, Missing); stomach: 57.1429% (minimum 70%, Missing); thymus: 59.0909% (minimum 65%, Missing); thyroid gland: 52.5253% (minimum 65%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.181532,-0.227273,-0.281532,0,3,partial,5.9,5.8,5.9,"cerebellum: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 3); hippocampal formation: 4.7 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); skeletal muscle: 4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); salivary gland: 3.8 nTPM (protected, limit 3); kidney: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175787,ZNF169,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1975% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.7701% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.5217% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 63.4146% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 46.8468% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 49.0566% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.2394% (minimum 75%, Baseline (adaptation disabled)); colon: 55.3191% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 67.5325% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 67.5325% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 52.5253% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.6506% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.0909% (minimum 75%, Baseline (adaptation disabled)); liver: 71.2329% (minimum 75%, Baseline (adaptation disabled)); lung: 62.6506% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.2727% (minimum 70%, Baseline (adaptation disabled)); midbrain: 62.6506% (minimum 75%, Baseline (adaptation disabled)); pancreas: 61.9048% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); rectum: 50.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 57.1429% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 57.7778% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 56.5217% (minimum 75%, Baseline (adaptation disabled)); skin: 51.4851% (minimum 65%, Baseline (adaptation disabled)); small intestine: 48.5981% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.8228% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.7701% (minimum 75%, Baseline (adaptation disabled)); spleen: 46.8468% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.1429% (minimum 70%, Baseline (adaptation disabled)); thymus: 59.0909% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.5253% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 70%, Baseline (adaptation disabled))",-0.181532,-0.227273,-0.281532,0,3,partial,5.9,5.8,5.9,"cerebellum: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 3); hippocampal formation: 4.7 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); skeletal muscle: 4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); salivary gland: 3.8 nTPM (protected, limit 3); kidney: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175787,ZNF169,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175809,CBLL2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175809,CBLL2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175809,CBLL2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175809,CBLL2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175809,CBLL2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 98.8506% (minimum 99%, Missing)",0.05,0.03,-0.00149425,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175820,CCDC168,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.238506,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175820,CCDC168,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.238506,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175820,CCDC168,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.238506,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175820,CCDC168,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.238506,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175820,CCDC168,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.00603699,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175877,TMEM270,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246037,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175877,TMEM270,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246037,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175877,TMEM270,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246037,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175877,TMEM270,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246037,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000175877,TMEM270,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.9130% (minimum 95%, Missing); adrenal gland: 68.0000% (minimum 99%, Missing); amygdala: 80.9524% (minimum 99%, Missing); basal ganglia: 73.9130% (minimum 99%, Missing); bone marrow: 53.1250% (minimum 99%, Missing); cerebellum: 68.0000% (minimum 99%, Missing); cerebral cortex: 85.0000% (minimum 99%, Missing); choroid plexus: 94.4444% (minimum 99%, Missing); colon: 77.2727% (minimum 97%, Missing); duodenum: 80.9524% (minimum 99%, Missing); esophagus: 65.3846% (minimum 97%, Missing); heart muscle: 65.3846% (minimum 99%, Missing); hippocampal formation: 85.0000% (minimum 99%, Missing); hypothalamus: 62.9630% (minimum 99%, Missing); kidney: 73.9130% (minimum 99%, Missing); liver: 48.5714% (minimum 99%, Missing); lung: 65.3846% (minimum 99%, Missing); lymph node: 77.2727% (minimum 97%, Missing); midbrain: 80.9524% (minimum 99%, Missing); pancreas: 53.1250% (minimum 99%, Missing); pituitary gland: 36.1702% (minimum 99%, Missing); retina: 94.4444% (minimum 99%, Missing); salivary gland: 65.3846% (minimum 97%, Missing); skeletal muscle: 34.0000% (minimum 99%, Missing); skin: 36.9565% (minimum 95%, Missing); small intestine: 70.8333% (minimum 99%, Missing); spinal cord: 73.9130% (minimum 99%, Missing); spleen: 62.9630% (minimum 95%, Missing); stomach: 62.9630% (minimum 97%, Missing); thymus: 85.0000% (minimum 95%, Missing); thyroid gland: 68.0000% (minimum 95%, Missing); urinary bladder: 77.2727% (minimum 97%, Missing)",-0.580435,-0.34037,-0.65,0,80,unavailable,3.3,1,2.9,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176020,AMIGO3,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.0000% (minimum 75%, Missing); basal ganglia: 73.9130% (minimum 75%, Missing); bone marrow: 53.1250% (minimum 75%, Missing); cerebellum: 68.0000% (minimum 75%, Missing); esophagus: 65.3846% (minimum 70%, Missing); heart muscle: 65.3846% (minimum 75%, Missing); hypothalamus: 62.9630% (minimum 75%, Missing); kidney: 73.9130% (minimum 75%, Missing); liver: 48.5714% (minimum 75%, Missing); lung: 65.3846% (minimum 75%, Missing); pancreas: 53.1250% (minimum 75%, Missing); pituitary gland: 36.1702% (minimum 75%, Missing); salivary gland: 65.3846% (minimum 70%, Missing); skeletal muscle: 34.0000% (minimum 75%, Missing); skin: 36.9565% (minimum 65%, Missing); small intestine: 70.8333% (minimum 75%, Missing); spinal cord: 73.9130% (minimum 75%, Missing); spleen: 62.9630% (minimum 65%, Missing); stomach: 62.9630% (minimum 70%, Missing)",-0.280435,-0.0703704,-0.41,0,80,unavailable,3.3,1,2.9,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176020,AMIGO3,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.0000% (minimum 75%, Missing); basal ganglia: 73.9130% (minimum 75%, Missing); bone marrow: 53.1250% (minimum 75%, Missing); cerebellum: 68.0000% (minimum 75%, Missing); esophagus: 65.3846% (minimum 70%, Missing); heart muscle: 65.3846% (minimum 75%, Missing); hypothalamus: 62.9630% (minimum 75%, Missing); kidney: 73.9130% (minimum 75%, Missing); liver: 48.5714% (minimum 75%, Missing); lung: 65.3846% (minimum 75%, Missing); pancreas: 53.1250% (minimum 75%, Missing); pituitary gland: 36.1702% (minimum 75%, Missing); salivary gland: 65.3846% (minimum 70%, Missing); skeletal muscle: 34.0000% (minimum 75%, Missing); skin: 36.9565% (minimum 65%, Missing); small intestine: 70.8333% (minimum 75%, Missing); spinal cord: 73.9130% (minimum 75%, Missing); spleen: 62.9630% (minimum 65%, Missing); stomach: 62.9630% (minimum 70%, Missing)",-0.280435,-0.0703704,-0.41,0,80,unavailable,3.3,1,2.9,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176020,AMIGO3,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.0000% (minimum 75%, Missing); basal ganglia: 73.9130% (minimum 75%, Missing); bone marrow: 53.1250% (minimum 75%, Missing); cerebellum: 68.0000% (minimum 75%, Missing); esophagus: 65.3846% (minimum 70%, Missing); heart muscle: 65.3846% (minimum 75%, Missing); hypothalamus: 62.9630% (minimum 75%, Missing); kidney: 73.9130% (minimum 75%, Missing); liver: 48.5714% (minimum 75%, Missing); lung: 65.3846% (minimum 75%, Missing); pancreas: 53.1250% (minimum 75%, Missing); pituitary gland: 36.1702% (minimum 75%, Missing); salivary gland: 65.3846% (minimum 70%, Missing); skeletal muscle: 34.0000% (minimum 75%, Missing); skin: 36.9565% (minimum 65%, Missing); small intestine: 70.8333% (minimum 75%, Missing); spinal cord: 73.9130% (minimum 75%, Missing); spleen: 62.9630% (minimum 65%, Missing); stomach: 62.9630% (minimum 70%, Missing)",-0.280435,-0.0703704,-0.41,0,80,unavailable,3.3,1,2.9,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176020,AMIGO3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.9130% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 53.1250% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.3846% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.3846% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.9630% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.9130% (minimum 75%, Baseline (adaptation disabled)); liver: 48.5714% (minimum 75%, Baseline (adaptation disabled)); lung: 65.3846% (minimum 75%, Baseline (adaptation disabled)); pancreas: 53.1250% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 36.1702% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.3846% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 34.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 36.9565% (minimum 65%, Baseline (adaptation disabled)); small intestine: 70.8333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.9130% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.9630% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.9630% (minimum 70%, Baseline (adaptation disabled))",-0.280435,-0.0703704,-0.41,0,80,unavailable,3.3,1,2.9,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176020,AMIGO3,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 86.6667% (minimum 99%, Missing); duodenum: 92.8571% (minimum 99%, Missing); lung: 92.8571% (minimum 99%, Missing); pancreas: 86.6667% (minimum 99%, Missing); pituitary gland: 92.8571% (minimum 99%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 86.6667% (minimum 99%, Missing); stomach: 86.6667% (minimum 97%, Missing); thymus: 86.6667% (minimum 95%, Missing); thyroid gland: 92.8571% (minimum 95%, Missing)",-0.0833333,-0.103333,-0.123333,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176040,TMPRSS7,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.216667,0.166667,0.116667,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176040,TMPRSS7,selectivity_revised,True,False,True,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.216667,0.166667,0.116667,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176040,TMPRSS7,grid_revised,True,False,True,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.216667,0.166667,0.116667,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176040,TMPRSS7,current_adaptive,True,False,True,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.216667,0.166667,0.116667,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176040,TMPRSS7,current_fixed,True,False,True,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 97.6687% (minimum 99%, Uncertain); lung: 94.5368% (minimum 99%, Missing); salivary gland: 89.0380% (minimum 97%, Missing); spinal cord: 98.0296% (minimum 99%, Missing); stomach: 96.0193% (minimum 97%, Missing)",0.0160194,-0.0796197,-0.0446318,0,2,partial,4.6,9.8,2.8,"salivary gland: 9.8 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176083,ZNF683,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.316019,0.19038,0.195368,0,2,partial,4.6,9.8,2.8,"salivary gland: 9.8 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176083,ZNF683,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.316019,0.19038,0.195368,0,2,partial,4.6,9.8,2.8,"salivary gland: 9.8 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176083,ZNF683,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.316019,0.19038,0.195368,0,2,partial,4.6,9.8,2.8,"salivary gland: 9.8 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176083,ZNF683,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.316019,0.19038,0.195368,0,2,partial,4.6,9.8,2.8,"salivary gland: 9.8 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176083,ZNF683,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.7132% (minimum 95%, Missing); adrenal gland: 58.1197% (minimum 99%, Missing); amygdala: 58.6207% (minimum 99%, Missing); basal ganglia: 64.1509% (minimum 99%, Missing); bone marrow: 48.2270% (minimum 99%, Missing); cerebellum: 56.1983% (minimum 99%, Missing); cerebral cortex: 35.7895% (minimum 99%, Missing); choroid plexus: 64.7619% (minimum 99%, Missing); colon: 50.3704% (minimum 97%, Missing); duodenum: 53.5433% (minimum 99%, Missing); esophagus: 59.1304% (minimum 97%, Missing); heart muscle: 60.1770% (minimum 98%, Approved); hippocampal formation: 56.1983% (minimum 99%, Missing); hypothalamus: 55.2846% (minimum 99%, Missing); kidney: 54.4000% (minimum 99%, Missing); liver: 63.5514% (minimum 99%, Missing); lung: 60.1770% (minimum 99%, Missing); lymph node: 58.6207% (minimum 97%, Missing); midbrain: 51.9084% (minimum 99%, Missing); pancreas: 55.2846% (minimum 99%, Missing); parathyroid gland: 63.5514% (minimum 97%, Missing); pituitary gland: 58.1197% (minimum 99%, Missing); rectum: 49.2754% (minimum 97%, Missing); retina: 53.9683% (minimum 99%, Missing); salivary gland: 58.6207% (minimum 97%, Missing); skeletal muscle: 70.1031% (minimum 98%, Approved); skin: 56.6667% (minimum 95%, Missing); small intestine: 44.1558% (minimum 99%, Missing); smooth muscle: 44.7368% (minimum 99%, Missing); spinal cord: 51.1278% (minimum 99%, Missing); spleen: 56.6667% (minimum 95%, Missing); stomach: 62.3853% (minimum 97%, Missing); thymus: 47.8873% (minimum 95%, Missing); thyroid gland: 68.6869% (minimum 95%, Missing); tongue: 63.5514% (minimum 97%, Missing); urinary bladder: 54.8387% (minimum 97%, Missing)",-0.471127,-0.477246,-0.632105,0,10,partial,12.2,7,7.4,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 2); hypothalamus: 5.5 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); lymph node: 4.8 nTPM (protected, limit 2); esophagus: 4.7 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 2); lung: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); liver: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); tongue: 3.9 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176148,TCP11L1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.7132% (minimum 65%, Missing); adrenal gland: 58.1197% (minimum 75%, Missing); amygdala: 58.6207% (minimum 75%, Missing); basal ganglia: 64.1509% (minimum 75%, Missing); bone marrow: 48.2270% (minimum 75%, Missing); cerebellum: 56.1983% (minimum 75%, Missing); cerebral cortex: 35.7895% (minimum 75%, Missing); choroid plexus: 64.7619% (minimum 75%, Missing); colon: 50.3704% (minimum 70%, Missing); duodenum: 53.5433% (minimum 75%, Missing); esophagus: 59.1304% (minimum 70%, Missing); heart muscle: 60.1770% (minimum 70%, Approved); hippocampal formation: 56.1983% (minimum 75%, Missing); hypothalamus: 55.2846% (minimum 75%, Missing); kidney: 54.4000% (minimum 75%, Missing); liver: 63.5514% (minimum 75%, Missing); lung: 60.1770% (minimum 75%, Missing); lymph node: 58.6207% (minimum 70%, Missing); midbrain: 51.9084% (minimum 75%, Missing); pancreas: 55.2846% (minimum 75%, Missing); parathyroid gland: 63.5514% (minimum 70%, Missing); pituitary gland: 58.1197% (minimum 75%, Missing); rectum: 49.2754% (minimum 70%, Missing); retina: 53.9683% (minimum 75%, Missing); salivary gland: 58.6207% (minimum 70%, Missing); skin: 56.6667% (minimum 65%, Missing); small intestine: 44.1558% (minimum 75%, Missing); smooth muscle: 44.7368% (minimum 75%, Missing); spinal cord: 51.1278% (minimum 75%, Missing); spleen: 56.6667% (minimum 65%, Missing); stomach: 62.3853% (minimum 70%, Missing); thymus: 47.8873% (minimum 65%, Missing); tongue: 63.5514% (minimum 70%, Missing); urinary bladder: 54.8387% (minimum 70%, Missing)",-0.171127,-0.207246,-0.392105,0,10,partial,12.2,7,7.4,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 2); hypothalamus: 5.5 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); lymph node: 4.8 nTPM (protected, limit 2); esophagus: 4.7 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 2); lung: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); liver: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); tongue: 3.9 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176148,TCP11L1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.7132% (minimum 65%, Missing); adrenal gland: 58.1197% (minimum 75%, Missing); amygdala: 58.6207% (minimum 75%, Missing); basal ganglia: 64.1509% (minimum 75%, Missing); bone marrow: 48.2270% (minimum 75%, Missing); cerebellum: 56.1983% (minimum 75%, Missing); cerebral cortex: 35.7895% (minimum 75%, Missing); choroid plexus: 64.7619% (minimum 75%, Missing); colon: 50.3704% (minimum 70%, Missing); duodenum: 53.5433% (minimum 75%, Missing); esophagus: 59.1304% (minimum 70%, Missing); heart muscle: 60.1770% (minimum 70%, Approved); hippocampal formation: 56.1983% (minimum 75%, Missing); hypothalamus: 55.2846% (minimum 75%, Missing); kidney: 54.4000% (minimum 75%, Missing); liver: 63.5514% (minimum 75%, Missing); lung: 60.1770% (minimum 75%, Missing); lymph node: 58.6207% (minimum 70%, Missing); midbrain: 51.9084% (minimum 75%, Missing); pancreas: 55.2846% (minimum 75%, Missing); parathyroid gland: 63.5514% (minimum 70%, Missing); pituitary gland: 58.1197% (minimum 75%, Missing); rectum: 49.2754% (minimum 70%, Missing); retina: 53.9683% (minimum 75%, Missing); salivary gland: 58.6207% (minimum 70%, Missing); skin: 56.6667% (minimum 65%, Missing); small intestine: 44.1558% (minimum 75%, Missing); smooth muscle: 44.7368% (minimum 75%, Missing); spinal cord: 51.1278% (minimum 75%, Missing); spleen: 56.6667% (minimum 65%, Missing); stomach: 62.3853% (minimum 70%, Missing); thymus: 47.8873% (minimum 65%, Missing); tongue: 63.5514% (minimum 70%, Missing); urinary bladder: 54.8387% (minimum 70%, Missing)",-0.171127,-0.207246,-0.392105,0,10,partial,12.2,7,7.4,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 3); hypothalamus: 5.5 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); lymph node: 4.8 nTPM (protected, limit 3); esophagus: 4.7 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 2); lung: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); liver: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); tongue: 3.9 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176148,TCP11L1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.7132% (minimum 65%, Missing); adrenal gland: 58.1197% (minimum 75%, Missing); amygdala: 58.6207% (minimum 75%, Missing); basal ganglia: 64.1509% (minimum 75%, Missing); bone marrow: 48.2270% (minimum 75%, Missing); cerebellum: 56.1983% (minimum 75%, Missing); cerebral cortex: 35.7895% (minimum 75%, Missing); choroid plexus: 64.7619% (minimum 75%, Missing); colon: 50.3704% (minimum 70%, Missing); duodenum: 53.5433% (minimum 75%, Missing); esophagus: 59.1304% (minimum 70%, Missing); heart muscle: 60.1770% (minimum 70%, Approved); hippocampal formation: 56.1983% (minimum 75%, Missing); hypothalamus: 55.2846% (minimum 75%, Missing); kidney: 54.4000% (minimum 75%, Missing); liver: 63.5514% (minimum 75%, Missing); lung: 60.1770% (minimum 75%, Missing); lymph node: 58.6207% (minimum 70%, Missing); midbrain: 51.9084% (minimum 75%, Missing); pancreas: 55.2846% (minimum 75%, Missing); parathyroid gland: 63.5514% (minimum 70%, Missing); pituitary gland: 58.1197% (minimum 75%, Missing); rectum: 49.2754% (minimum 70%, Missing); retina: 53.9683% (minimum 75%, Missing); salivary gland: 58.6207% (minimum 70%, Missing); skin: 56.6667% (minimum 65%, Missing); small intestine: 44.1558% (minimum 75%, Missing); smooth muscle: 44.7368% (minimum 75%, Missing); spinal cord: 51.1278% (minimum 75%, Missing); spleen: 56.6667% (minimum 65%, Missing); stomach: 62.3853% (minimum 70%, Missing); thymus: 47.8873% (minimum 65%, Missing); tongue: 63.5514% (minimum 70%, Missing); urinary bladder: 54.8387% (minimum 70%, Missing)",-0.171127,-0.207246,-0.392105,0,10,partial,12.2,7,7.4,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 3); hypothalamus: 5.5 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); lymph node: 4.8 nTPM (protected, limit 3); esophagus: 4.7 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 2); lung: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); liver: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); tongue: 3.9 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176148,TCP11L1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.7132% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 58.1197% (minimum 75%, Baseline (adaptation disabled)); amygdala: 58.6207% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.1509% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 48.2270% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.1983% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 35.7895% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.7619% (minimum 75%, Baseline (adaptation disabled)); colon: 50.3704% (minimum 70%, Baseline (adaptation disabled)); duodenum: 53.5433% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.1304% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.1770% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 56.1983% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.2846% (minimum 75%, Baseline (adaptation disabled)); kidney: 54.4000% (minimum 75%, Baseline (adaptation disabled)); liver: 63.5514% (minimum 75%, Baseline (adaptation disabled)); lung: 60.1770% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.6207% (minimum 70%, Baseline (adaptation disabled)); midbrain: 51.9084% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.2846% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.5514% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.1197% (minimum 75%, Baseline (adaptation disabled)); rectum: 49.2754% (minimum 70%, Baseline (adaptation disabled)); retina: 53.9683% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.6207% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 70.1031% (minimum 75%, Baseline (adaptation disabled)); skin: 56.6667% (minimum 65%, Baseline (adaptation disabled)); small intestine: 44.1558% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 44.7368% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 51.1278% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.6667% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.3853% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.8873% (minimum 65%, Baseline (adaptation disabled)); tongue: 63.5514% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 54.8387% (minimum 70%, Baseline (adaptation disabled))",-0.171127,-0.207246,-0.392105,0,10,partial,12.2,7,7.4,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 3); hypothalamus: 5.5 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); lymph node: 4.8 nTPM (protected, limit 3); esophagus: 4.7 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); liver: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); tongue: 3.9 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176148,TCP11L1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.033368,0.03,0.0078903,0,2,partial,0.4,1.1,0.8,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176160,HSF5,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333368,0.3,0.24789,0,2,partial,0.4,1.1,0.8,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176160,HSF5,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333368,0.3,0.24789,0,2,partial,0.4,1.1,0.8,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176160,HSF5,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333368,0.3,0.24789,0,2,partial,0.4,1.1,0.8,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176160,HSF5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.333368,0.277273,0.241614,0,2,partial,0.4,1.1,0.8,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176160,HSF5,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 20.2128% (minimum 99%, Missing); basal ganglia: 16.8889% (minimum 99%, Missing); cerebellum: 97.4359% (minimum 99%, Missing); cerebral cortex: 15.5738% (minimum 99%, Missing); choroid plexus: 90.4762% (minimum 99%, Missing); esophagus: 95.0000% (minimum 97%, Missing); hippocampal formation: 19.7917% (minimum 99%, Missing); hypothalamus: 62.2951% (minimum 99%, Missing); lymph node: 88.3721% (minimum 97%, Missing); midbrain: 97.4359% (minimum 99%, Missing); pituitary gland: 58.4615% (minimum 99%, Missing); retina: 92.6829% (minimum 99%, Missing); thymus: 55.8824% (minimum 95%, Missing)",-0.391176,-0.0862791,-0.834262,0,80,unavailable,20.6,0.5,3,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176165,FOXG1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 20.2128% (minimum 75%, Missing); basal ganglia: 16.8889% (minimum 75%, Missing); cerebral cortex: 15.5738% (minimum 75%, Missing); hippocampal formation: 19.7917% (minimum 75%, Missing); hypothalamus: 62.2951% (minimum 75%, Missing); pituitary gland: 58.4615% (minimum 75%, Missing); thymus: 55.8824% (minimum 65%, Missing)",-0.0911765,0.183721,-0.594262,0,80,unavailable,20.6,0.5,3,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176165,FOXG1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 20.2128% (minimum 75%, Missing); basal ganglia: 16.8889% (minimum 75%, Missing); cerebral cortex: 15.5738% (minimum 75%, Missing); hippocampal formation: 19.7917% (minimum 75%, Missing); hypothalamus: 62.2951% (minimum 75%, Missing); pituitary gland: 58.4615% (minimum 75%, Missing); thymus: 55.8824% (minimum 65%, Missing)",-0.0911765,0.183721,-0.594262,0,80,unavailable,20.6,0.5,3,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176165,FOXG1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 20.2128% (minimum 75%, Missing); basal ganglia: 16.8889% (minimum 75%, Missing); cerebral cortex: 15.5738% (minimum 75%, Missing); hippocampal formation: 19.7917% (minimum 75%, Missing); hypothalamus: 62.2951% (minimum 75%, Missing); pituitary gland: 58.4615% (minimum 75%, Missing); thymus: 55.8824% (minimum 65%, Missing)",-0.0911765,0.183721,-0.594262,0,80,unavailable,20.6,0.5,3,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176165,FOXG1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 20.2128% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 16.8889% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 15.5738% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 19.7917% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.2951% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 58.4615% (minimum 75%, Baseline (adaptation disabled)); thymus: 55.8824% (minimum 65%, Baseline (adaptation disabled))",-0.0911765,0.183721,-0.594262,0,80,unavailable,20.6,0.5,3,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176165,FOXG1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 92.2414% (minimum 99%, Missing); lymph node: 94.6903% (minimum 97%, Missing); thymus: 89.1667% (minimum 95%, Missing)",-0.0583333,-0.0230973,-0.0675862,0,80,unavailable,0.9,0.6,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176177,ENTHD1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.241667,0.246903,0.172414,0,80,unavailable,0.9,0.6,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176177,ENTHD1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.241667,0.246903,0.172414,0,80,unavailable,0.9,0.6,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176177,ENTHD1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.241667,0.246903,0.172414,0,80,unavailable,0.9,0.6,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176177,ENTHD1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.241667,0.246903,0.172414,0,80,unavailable,0.9,0.6,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176177,ENTHD1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176198,OR11H4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176198,OR11H4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176198,OR11H4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176198,OR11H4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176198,OR11H4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.0769% (minimum 95%, Missing); adrenal gland: 82.6087% (minimum 99%, Missing); amygdala: 86.3636% (minimum 99%, Missing); basal ganglia: 82.6087% (minimum 99%, Missing); bone marrow: 13.4752% (minimum 99%, Missing); cerebellum: 51.3514% (minimum 99%, Missing); cerebral cortex: 76.0000% (minimum 99%, Missing); choroid plexus: 95.0000% (minimum 99%, Missing); colon: 61.2903% (minimum 97%, Missing); duodenum: 57.5758% (minimum 99%, Missing); esophagus: 59.3750% (minimum 97%, Missing); heart muscle: 82.6087% (minimum 99%, Missing); hippocampal formation: 86.3636% (minimum 99%, Missing); hypothalamus: 82.6087% (minimum 99%, Missing); kidney: 86.3636% (minimum 99%, Missing); liver: 79.1667% (minimum 99%, Missing); lung: 73.0769% (minimum 99%, Missing); lymph node: 35.1852% (minimum 97%, Missing); midbrain: 86.3636% (minimum 99%, Missing); pancreas: 79.1667% (minimum 99%, Missing); parathyroid gland: 86.3636% (minimum 97%, Missing); pituitary gland: 79.1667% (minimum 99%, Missing); rectum: 55.8824% (minimum 97%, Missing); retina: 44.1860% (minimum 99%, Missing); salivary gland: 73.0769% (minimum 97%, Missing); skeletal muscle: 82.6087% (minimum 99%, Missing); skin: 44.1860% (minimum 95%, Missing); small intestine: 59.3750% (minimum 99%, Missing); smooth muscle: 76.0000% (minimum 99%, Missing); spinal cord: 82.6087% (minimum 99%, Missing); spleen: 59.3750% (minimum 95%, Missing); stomach: 65.5172% (minimum 97%, Missing); thymus: 26.7606% (minimum 95%, Missing); thyroid gland: 79.1667% (minimum 95%, Missing); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 76.0000% (minimum 97%, Missing)",-0.682394,-0.618148,-0.855248,0,80,unavailable,12.2,3.5,5.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 3.5 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176208,ATAD5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 13.4752% (minimum 75%, Missing); cerebellum: 51.3514% (minimum 75%, Missing); colon: 61.2903% (minimum 70%, Missing); duodenum: 57.5758% (minimum 75%, Missing); esophagus: 59.3750% (minimum 70%, Missing); lung: 73.0769% (minimum 75%, Missing); lymph node: 35.1852% (minimum 70%, Missing); rectum: 55.8824% (minimum 70%, Missing); retina: 44.1860% (minimum 75%, Missing); skin: 44.1860% (minimum 65%, Missing); small intestine: 59.3750% (minimum 75%, Missing); spleen: 59.3750% (minimum 65%, Missing); stomach: 65.5172% (minimum 70%, Missing); thymus: 26.7606% (minimum 65%, Missing)",-0.382394,-0.348148,-0.615248,0,80,unavailable,12.2,3.5,5.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 3.5 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176208,ATAD5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 13.4752% (minimum 75%, Missing); cerebellum: 51.3514% (minimum 75%, Missing); colon: 61.2903% (minimum 70%, Missing); duodenum: 57.5758% (minimum 75%, Missing); esophagus: 59.3750% (minimum 70%, Missing); lung: 73.0769% (minimum 75%, Missing); lymph node: 35.1852% (minimum 70%, Missing); rectum: 55.8824% (minimum 70%, Missing); retina: 44.1860% (minimum 75%, Missing); skin: 44.1860% (minimum 65%, Missing); small intestine: 59.3750% (minimum 75%, Missing); spleen: 59.3750% (minimum 65%, Missing); stomach: 65.5172% (minimum 70%, Missing); thymus: 26.7606% (minimum 65%, Missing)",-0.382394,-0.348148,-0.615248,0,80,unavailable,12.2,3.5,5.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 3.5 nTPM (protected, limit 3); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176208,ATAD5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 13.4752% (minimum 75%, Missing); cerebellum: 51.3514% (minimum 75%, Missing); colon: 61.2903% (minimum 70%, Missing); duodenum: 57.5758% (minimum 75%, Missing); esophagus: 59.3750% (minimum 70%, Missing); lung: 73.0769% (minimum 75%, Missing); lymph node: 35.1852% (minimum 70%, Missing); rectum: 55.8824% (minimum 70%, Missing); retina: 44.1860% (minimum 75%, Missing); skin: 44.1860% (minimum 65%, Missing); small intestine: 59.3750% (minimum 75%, Missing); spleen: 59.3750% (minimum 65%, Missing); stomach: 65.5172% (minimum 70%, Missing); thymus: 26.7606% (minimum 65%, Missing)",-0.382394,-0.348148,-0.615248,0,80,unavailable,12.2,3.5,5.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 3.5 nTPM (protected, limit 3); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176208,ATAD5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 13.4752% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 51.3514% (minimum 75%, Baseline (adaptation disabled)); colon: 61.2903% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.5758% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.3750% (minimum 70%, Baseline (adaptation disabled)); lung: 73.0769% (minimum 75%, Baseline (adaptation disabled)); lymph node: 35.1852% (minimum 70%, Baseline (adaptation disabled)); rectum: 55.8824% (minimum 70%, Baseline (adaptation disabled)); retina: 44.1860% (minimum 75%, Baseline (adaptation disabled)); skin: 44.1860% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.3750% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.3750% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.5172% (minimum 70%, Baseline (adaptation disabled)); thymus: 26.7606% (minimum 65%, Baseline (adaptation disabled))",-0.382394,-0.348148,-0.615248,0,80,unavailable,12.2,3.5,5.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 3.5 nTPM (protected, limit 3); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176208,ATAD5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000176219,OR11H6,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000176219,OR11H6,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000176219,OR11H6,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000176219,OR11H6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000176219,OR11H6,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176256,HMGB4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176256,HMGB4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176256,HMGB4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176256,HMGB4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.249723,0,4,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176256,HMGB4,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 88.0952% (minimum 99%, Missing); heart muscle: 97.3684% (minimum 99%, Missing); tongue: 88.0952% (minimum 97%, Missing)",0.05,-0.0890476,-0.109048,0,80,unavailable,0.5,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176294,OR4N2,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.180952,0.130952,0,80,unavailable,0.5,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176294,OR4N2,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.180952,0.130952,0,80,unavailable,0.5,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176294,OR4N2,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.180952,0.130952,0,80,unavailable,0.5,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176294,OR4N2,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.180952,0.130952,0,80,unavailable,0.5,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176294,OR4N2,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176299,OR4M1,admission_only,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176299,OR4M1,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176299,OR4M1,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176299,OR4M1,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176299,OR4M1,current_fixed,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 97.6190% (minimum 99%, Missing)",0.0261905,0.03,-0.0138095,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176302,FOXR1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.32619,0.3,0.22619,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176302,FOXR1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.32619,0.3,0.22619,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176302,FOXR1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.32619,0.3,0.22619,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176302,FOXR1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.32619,0.3,0.22619,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176302,FOXR1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.4932% (minimum 90%, Approved); adrenal gland: 58.8235% (minimum 99%, Missing); amygdala: 37.0370% (minimum 99%, Missing); basal ganglia: 29.7619% (minimum 99%, Missing); bone marrow: 79.3651% (minimum 98%, Approved); cerebellum: 23.9234% (minimum 98%, Approved); cerebral cortex: 31.0559% (minimum 99%, Missing); choroid plexus: 49.5050% (minimum 99%, Missing); colon: 58.1395% (minimum 97%, Missing); duodenum: 79.3651% (minimum 99%, Missing); esophagus: 80.6452% (minimum 95%, Approved); heart muscle: 63.2911% (minimum 99%, Missing); hippocampal formation: 39.0625% (minimum 99%, Missing); hypothalamus: 27.0270% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 83.3333% (minimum 98%, Approved); lung: 70.4225% (minimum 99%, Missing); lymph node: 60.9756% (minimum 95%, Approved); midbrain: 47.1698% (minimum 99%, Missing); pancreas: 78.1250% (minimum 99%, Missing); parathyroid gland: 73.5294% (minimum 95%, Approved); pituitary gland: 33.3333% (minimum 99%, Missing); rectum: 84.7458% (minimum 97%, Missing); retina: 35.2113% (minimum 99%, Missing); salivary gland: 79.3651% (minimum 95%, Approved); skeletal muscle: 71.4286% (minimum 98%, Approved); skin: 84.7458% (minimum 95%, Missing); small intestine: 67.5676% (minimum 99%, Missing); smooth muscle: 76.9231% (minimum 99%, Missing); spinal cord: 51.5464% (minimum 99%, Missing); spleen: 60.2410% (minimum 90%, Approved); stomach: 72.4638% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 58.1395% (minimum 95%, Missing); tongue: 80.6452% (minimum 97%, Missing); urinary bladder: 63.2911% (minimum 97%, Missing)",-0.368605,-0.388605,-0.740766,0,7,partial,15.9,3.6,3.6,"cerebellum: 15.9 nTPM (vital, limit 2); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176401,EID2B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 58.8235% (minimum 75%, Missing); amygdala: 37.0370% (minimum 75%, Missing); basal ganglia: 29.7619% (minimum 75%, Missing); cerebellum: 23.9234% (minimum 70%, Approved); cerebral cortex: 31.0559% (minimum 75%, Missing); choroid plexus: 49.5050% (minimum 75%, Missing); colon: 58.1395% (minimum 70%, Missing); heart muscle: 63.2911% (minimum 75%, Missing); hippocampal formation: 39.0625% (minimum 75%, Missing); hypothalamus: 27.0270% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 70.4225% (minimum 75%, Missing); lymph node: 60.9756% (minimum 65%, Approved); midbrain: 47.1698% (minimum 75%, Missing); pituitary gland: 33.3333% (minimum 75%, Missing); retina: 35.2113% (minimum 75%, Missing); small intestine: 67.5676% (minimum 75%, Missing); spinal cord: 51.5464% (minimum 75%, Missing); thyroid gland: 58.1395% (minimum 65%, Missing); urinary bladder: 63.2911% (minimum 70%, Missing)",-0.0686047,-0.118605,-0.47973,0,7,partial,15.9,3.6,3.6,"cerebellum: 15.9 nTPM (vital, limit 2); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176401,EID2B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 58.8235% (minimum 75%, Missing); amygdala: 37.0370% (minimum 75%, Missing); basal ganglia: 29.7619% (minimum 75%, Missing); cerebellum: 23.9234% (minimum 70%, Approved); cerebral cortex: 31.0559% (minimum 75%, Missing); choroid plexus: 49.5050% (minimum 75%, Missing); colon: 58.1395% (minimum 70%, Missing); heart muscle: 63.2911% (minimum 75%, Missing); hippocampal formation: 39.0625% (minimum 75%, Missing); hypothalamus: 27.0270% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 70.4225% (minimum 75%, Missing); lymph node: 60.9756% (minimum 65%, Approved); midbrain: 47.1698% (minimum 75%, Missing); pituitary gland: 33.3333% (minimum 75%, Missing); retina: 35.2113% (minimum 75%, Missing); small intestine: 67.5676% (minimum 75%, Missing); spinal cord: 51.5464% (minimum 75%, Missing); thyroid gland: 58.1395% (minimum 65%, Missing); urinary bladder: 63.2911% (minimum 70%, Missing)",-0.0686047,-0.118605,-0.47973,0,7,partial,15.9,3.6,3.6,"cerebellum: 15.9 nTPM (vital, limit 2); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176401,EID2B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 58.8235% (minimum 75%, Missing); amygdala: 37.0370% (minimum 75%, Missing); basal ganglia: 29.7619% (minimum 75%, Missing); cerebellum: 23.9234% (minimum 70%, Approved); cerebral cortex: 31.0559% (minimum 75%, Missing); choroid plexus: 49.5050% (minimum 75%, Missing); colon: 58.1395% (minimum 70%, Missing); heart muscle: 63.2911% (minimum 75%, Missing); hippocampal formation: 39.0625% (minimum 75%, Missing); hypothalamus: 27.0270% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 70.4225% (minimum 75%, Missing); lymph node: 60.9756% (minimum 65%, Approved); midbrain: 47.1698% (minimum 75%, Missing); pituitary gland: 33.3333% (minimum 75%, Missing); retina: 35.2113% (minimum 75%, Missing); small intestine: 67.5676% (minimum 75%, Missing); spinal cord: 51.5464% (minimum 75%, Missing); thyroid gland: 58.1395% (minimum 65%, Missing); urinary bladder: 63.2911% (minimum 70%, Missing)",-0.0686047,-0.118605,-0.47973,0,7,partial,15.9,3.6,3.6,"cerebellum: 15.9 nTPM (vital, limit 2); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176401,EID2B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 58.8235% (minimum 75%, Baseline (adaptation disabled)); amygdala: 37.0370% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 29.7619% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 23.9234% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 31.0559% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 49.5050% (minimum 75%, Baseline (adaptation disabled)); colon: 58.1395% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.2911% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 39.0625% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 27.0270% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lung: 70.4225% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.9756% (minimum 70%, Baseline (adaptation disabled)); midbrain: 47.1698% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 33.3333% (minimum 75%, Baseline (adaptation disabled)); retina: 35.2113% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); small intestine: 67.5676% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 51.5464% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.2410% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.1395% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 63.2911% (minimum 70%, Baseline (adaptation disabled))",-0.0686047,-0.118605,-0.510766,0,7,partial,15.9,3.6,3.6,"cerebellum: 15.9 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176401,EID2B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.5612% (minimum 99%, Missing); cerebral cortex: 97.3934% (minimum 99%, Missing); kidney: 96.4789% (minimum 99%, Missing); lung: 98.7981% (minimum 99%, Missing); pancreas: 97.6247% (minimum 99%, Missing); rectum: 95.8042% (minimum 97%, Missing); spinal cord: 98.3254% (minimum 99%, Missing); stomach: 92.7765% (minimum 97%, Missing)",0.0427536,-0.0422348,-0.0252113,0,80,unavailable,1.5,3.2,0.3,"stomach: 3.2 nTPM (protected, limit 2); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176563,CNTD1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342754,0.227765,0.214789,0,80,unavailable,1.5,3.2,0.3,"stomach: 3.2 nTPM (protected, limit 2); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176563,CNTD1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342754,0.227765,0.214789,0,80,unavailable,1.5,3.2,0.3,"stomach: 3.2 nTPM (protected, limit 3); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176563,CNTD1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342754,0.227765,0.214789,0,80,unavailable,1.5,3.2,0.3,"stomach: 3.2 nTPM (protected, limit 3); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176563,CNTD1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342754,0.227765,0.214789,0,80,unavailable,1.5,3.2,0.3,"stomach: 3.2 nTPM (protected, limit 3); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176563,CNTD1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176566,DCAF4L2,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176566,DCAF4L2,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176566,DCAF4L2,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176566,DCAF4L2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176566,DCAF4L2,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.0000% (minimum 99%, Missing); spleen: 94.2308% (minimum 95%, Missing)",-0.00769231,0.01,-0.01,0,80,unavailable,0.1,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176571,CNBD1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.292308,0.28,0.23,0,80,unavailable,0.1,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176571,CNBD1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.292308,0.28,0.23,0,80,unavailable,0.1,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176571,CNBD1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.292308,0.28,0.23,0,80,unavailable,0.1,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176571,CNBD1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.292308,0.28,0.23,0,80,unavailable,0.1,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176571,CNBD1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.8153% (minimum 95%, Uncertain); adrenal gland: 85.3503% (minimum 99%, Missing); amygdala: 86.4516% (minimum 99%, Missing); basal ganglia: 86.4516% (minimum 99%, Missing); bone marrow: 15.0393% (minimum 99%, Missing); cerebellum: 94.3662% (minimum 99%, Missing); cerebral cortex: 82.2086% (minimum 99%, Missing); choroid plexus: 87.5817% (minimum 99%, Missing); colon: 37.9603% (minimum 97%, Missing); duodenum: 26.5347% (minimum 99%, Missing); esophagus: 26.9618% (minimum 97%, Missing); heart muscle: 79.7619% (minimum 99%, Missing); hippocampal formation: 84.8101% (minimum 99%, Missing); hypothalamus: 83.2298% (minimum 99%, Missing); kidney: 78.8235% (minimum 99%, Missing); liver: 80.7229% (minimum 99%, Missing); lung: 48.0287% (minimum 99%, Missing); lymph node: 92.4138% (minimum 97%, Missing); midbrain: 82.7160% (minimum 99%, Missing); pancreas: 65.0485% (minimum 99%, Missing); parathyroid gland: 79.7619% (minimum 97%, Missing); pituitary gland: 70.5263% (minimum 99%, Missing); rectum: 41.3580% (minimum 97%, Uncertain); retina: 92.4138% (minimum 99%, Missing); salivary gland: 57.7586% (minimum 97%, Uncertain); skeletal muscle: 65.0485% (minimum 99%, Uncertain); skin: 57.2650% (minimum 95%, Missing); small intestine: 24.7232% (minimum 99%, Missing); smooth muscle: 67.3367% (minimum 99%, Missing); spinal cord: 75.7062% (minimum 99%, Missing); spleen: 89.3333% (minimum 95%, Missing); stomach: 54.9180% (minimum 97%, Missing); thymus: 64.4231% (minimum 95%, Missing); thyroid gland: 72.4324% (minimum 95%, Missing); tongue: 75.7062% (minimum 97%, Missing); urinary bladder: 36.5123% (minimum 97%, Missing)",-0.411847,-0.700382,-0.839607,0,1,partial,75.7,36.3,11.5,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 2); urinary bladder: 23.3 nTPM (protected, limit 2); colon: 21.9 nTPM (protected, limit 2); rectum: 19 nTPM (protected, limit 2); lung: 14.5 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); stomach: 11 nTPM (protected, limit 2); skin: 10 nTPM (manageable, limit 5); salivary gland: 9.8 nTPM (protected, limit 2); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.2 nTPM (vital, limit 1); skeletal muscle: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176597,B3GNT5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.8153% (minimum 65%, Uncertain); bone marrow: 15.0393% (minimum 75%, Missing); colon: 37.9603% (minimum 70%, Missing); duodenum: 26.5347% (minimum 75%, Missing); esophagus: 26.9618% (minimum 70%, Missing); lung: 48.0287% (minimum 75%, Missing); pancreas: 65.0485% (minimum 75%, Missing); pituitary gland: 70.5263% (minimum 75%, Missing); rectum: 41.3580% (minimum 70%, Uncertain); salivary gland: 57.7586% (minimum 70%, Uncertain); skeletal muscle: 65.0485% (minimum 75%, Uncertain); skin: 57.2650% (minimum 65%, Missing); small intestine: 24.7232% (minimum 75%, Missing); smooth muscle: 67.3367% (minimum 75%, Missing); stomach: 54.9180% (minimum 70%, Missing); thymus: 64.4231% (minimum 65%, Missing); urinary bladder: 36.5123% (minimum 70%, Missing)",-0.111847,-0.430382,-0.599607,0,1,partial,75.7,36.3,11.5,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 2); urinary bladder: 23.3 nTPM (protected, limit 2); colon: 21.9 nTPM (protected, limit 2); rectum: 19 nTPM (protected, limit 2); lung: 14.5 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); stomach: 11 nTPM (protected, limit 2); skin: 10 nTPM (manageable, limit 5); salivary gland: 9.8 nTPM (protected, limit 2); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.2 nTPM (vital, limit 1); skeletal muscle: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176597,B3GNT5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.8153% (minimum 65%, Uncertain); bone marrow: 15.0393% (minimum 75%, Missing); colon: 37.9603% (minimum 70%, Missing); duodenum: 26.5347% (minimum 75%, Missing); esophagus: 26.9618% (minimum 70%, Missing); lung: 48.0287% (minimum 75%, Missing); pancreas: 65.0485% (minimum 75%, Missing); pituitary gland: 70.5263% (minimum 75%, Missing); rectum: 41.3580% (minimum 70%, Uncertain); salivary gland: 57.7586% (minimum 70%, Uncertain); skeletal muscle: 65.0485% (minimum 75%, Uncertain); skin: 57.2650% (minimum 65%, Missing); small intestine: 24.7232% (minimum 75%, Missing); smooth muscle: 67.3367% (minimum 75%, Missing); stomach: 54.9180% (minimum 70%, Missing); thymus: 64.4231% (minimum 65%, Missing); urinary bladder: 36.5123% (minimum 70%, Missing)",-0.111847,-0.430382,-0.599607,0,1,partial,75.7,36.3,11.5,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 3); urinary bladder: 23.3 nTPM (protected, limit 3); colon: 21.9 nTPM (protected, limit 3); rectum: 19 nTPM (protected, limit 3); lung: 14.5 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); stomach: 11 nTPM (protected, limit 3); skin: 10 nTPM (manageable, limit 5); salivary gland: 9.8 nTPM (protected, limit 3); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.2 nTPM (vital, limit 1); skeletal muscle: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176597,B3GNT5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.8153% (minimum 65%, Uncertain); bone marrow: 15.0393% (minimum 75%, Missing); colon: 37.9603% (minimum 70%, Missing); duodenum: 26.5347% (minimum 75%, Missing); esophagus: 26.9618% (minimum 70%, Missing); lung: 48.0287% (minimum 75%, Missing); pancreas: 65.0485% (minimum 75%, Missing); pituitary gland: 70.5263% (minimum 75%, Missing); rectum: 41.3580% (minimum 70%, Uncertain); salivary gland: 57.7586% (minimum 70%, Uncertain); skeletal muscle: 65.0485% (minimum 75%, Uncertain); skin: 57.2650% (minimum 65%, Missing); small intestine: 24.7232% (minimum 75%, Missing); smooth muscle: 67.3367% (minimum 75%, Missing); stomach: 54.9180% (minimum 70%, Missing); thymus: 64.4231% (minimum 65%, Missing); urinary bladder: 36.5123% (minimum 70%, Missing)",-0.111847,-0.430382,-0.599607,0,1,partial,75.7,36.3,11.5,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 3); urinary bladder: 23.3 nTPM (protected, limit 3); colon: 21.9 nTPM (protected, limit 3); rectum: 19 nTPM (protected, limit 3); lung: 14.5 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); stomach: 11 nTPM (protected, limit 3); skin: 10 nTPM (manageable, limit 5); salivary gland: 9.8 nTPM (protected, limit 3); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.2 nTPM (vital, limit 1); skeletal muscle: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176597,B3GNT5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.8153% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 15.0393% (minimum 75%, Baseline (adaptation disabled)); colon: 37.9603% (minimum 70%, Baseline (adaptation disabled)); duodenum: 26.5347% (minimum 75%, Baseline (adaptation disabled)); esophagus: 26.9618% (minimum 70%, Baseline (adaptation disabled)); lung: 48.0287% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.0485% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 70.5263% (minimum 75%, Baseline (adaptation disabled)); rectum: 41.3580% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 57.7586% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 65.0485% (minimum 75%, Baseline (adaptation disabled)); skin: 57.2650% (minimum 65%, Baseline (adaptation disabled)); small intestine: 24.7232% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.3367% (minimum 75%, Baseline (adaptation disabled)); stomach: 54.9180% (minimum 70%, Baseline (adaptation disabled)); thymus: 64.4231% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 36.5123% (minimum 70%, Baseline (adaptation disabled))",-0.111847,-0.430382,-0.599607,0,1,partial,75.7,36.3,11.5,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 3); urinary bladder: 23.3 nTPM (protected, limit 3); colon: 21.9 nTPM (protected, limit 3); rectum: 19 nTPM (protected, limit 3); lung: 14.5 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); stomach: 11 nTPM (protected, limit 3); skin: 10 nTPM (manageable, limit 5); salivary gland: 9.8 nTPM (protected, limit 3); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.2 nTPM (vital, limit 1); skeletal muscle: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176597,B3GNT5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 88.8000% (minimum 95%, Enhanced)",0.05,0.03,-0.062,0,4,partial,2.8,0.1,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176635,HORMAD2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.241071,0,4,partial,2.8,0.1,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176635,HORMAD2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.241071,0,4,partial,2.8,0.1,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176635,HORMAD2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.241071,0,4,partial,2.8,0.1,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176635,HORMAD2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345516,0.295516,0.138,0,4,partial,2.8,0.1,0.1,"liver: 2.8 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176635,HORMAD2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176679,TGIF2LY,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176679,TGIF2LY,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176679,TGIF2LY,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176679,TGIF2LY,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176679,TGIF2LY,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.9950% (minimum 99%, Missing); heart muscle: 98.5000% (minimum 99%, Missing); kidney: 98.6233% (minimum 99%, Missing); pituitary gland: 98.5000% (minimum 99%, Missing); retina: 96.4504% (minimum 99%, Missing); skeletal muscle: 98.8708% (minimum 99%, Missing)",0.026456,0.0174687,-0.0254957,0,80,unavailable,2.9,1,1.9,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176732,PFN4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326456,0.287469,0.214504,0,80,unavailable,2.9,1,1.9,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176732,PFN4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326456,0.287469,0.214504,0,80,unavailable,2.9,1,1.9,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176732,PFN4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326456,0.287469,0.214504,0,80,unavailable,2.9,1,1.9,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176732,PFN4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326456,0.287469,0.214504,0,80,unavailable,2.9,1,1.9,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176732,PFN4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.05,0.03,0.01,0,3,unreliable,0,0,0,,kidney / proximal tubules (microvilli): Medium (Enhanced),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176746,MAGEB6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.25,0,3,unreliable,0,0,0,,kidney / proximal tubules (microvilli): Medium (Enhanced),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176746,MAGEB6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.25,0,3,unreliable,0,0,0,,kidney / proximal tubules (microvilli): Medium (Enhanced),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176746,MAGEB6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.25,0,3,unreliable,0,0,0,,kidney / proximal tubules (microvilli): Medium (Enhanced),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176746,MAGEB6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.25,0,3,unreliable,0,0,0,,kidney / proximal tubules (microvilli): Medium (Enhanced),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176746,MAGEB6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.0435% (minimum 95%, Missing); adrenal gland: 74.3590% (minimum 99%, Missing); amygdala: 44.6154% (minimum 99%, Missing); basal ganglia: 41.4286% (minimum 99%, Missing); cerebellum: 76.3158% (minimum 99%, Missing); cerebral cortex: 53.7037% (minimum 99%, Missing); choroid plexus: 60.4167% (minimum 99%, Missing); colon: 72.5000% (minimum 97%, Missing); duodenum: 58.0000% (minimum 99%, Missing); esophagus: 43.2836% (minimum 97%, Missing); heart muscle: 53.7037% (minimum 99%, Missing); hippocampal formation: 40.8451% (minimum 99%, Missing); hypothalamus: 50.8772% (minimum 99%, Missing); kidney: 42.6471% (minimum 99%, Missing); liver: 42.6471% (minimum 99%, Missing); lung: 20.7143% (minimum 99%, Missing); lymph node: 69.0476% (minimum 97%, Missing); midbrain: 36.7089% (minimum 99%, Missing); pancreas: 74.3590% (minimum 99%, Missing); parathyroid gland: 82.8571% (minimum 97%, Missing); pituitary gland: 85.2941% (minimum 99%, Missing); rectum: 74.3590% (minimum 97%, Missing); retina: 38.6667% (minimum 99%, Missing); salivary gland: 59.1837% (minimum 97%, Missing); skeletal muscle: 85.2941% (minimum 99%, Missing); skin: 59.1837% (minimum 95%, Missing); small intestine: 48.3333% (minimum 99%, Missing); smooth muscle: 87.8788% (minimum 99%, Missing); spinal cord: 37.1795% (minimum 99%, Missing); spleen: 63.0435% (minimum 95%, Missing); stomach: 63.0435% (minimum 97%, Missing); thymus: 80.5556% (minimum 95%, Missing); thyroid gland: 76.3158% (minimum 95%, Missing); tongue: 82.8571% (minimum 97%, Missing); urinary bladder: 85.2941% (minimum 97%, Missing)",-0.358163,-0.537164,-0.782857,0,80,unavailable,11.1,3.8,2,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176771,NCKAP5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.0435% (minimum 65%, Missing); adrenal gland: 74.3590% (minimum 75%, Missing); amygdala: 44.6154% (minimum 75%, Missing); basal ganglia: 41.4286% (minimum 75%, Missing); cerebral cortex: 53.7037% (minimum 75%, Missing); choroid plexus: 60.4167% (minimum 75%, Missing); duodenum: 58.0000% (minimum 75%, Missing); esophagus: 43.2836% (minimum 70%, Missing); heart muscle: 53.7037% (minimum 75%, Missing); hippocampal formation: 40.8451% (minimum 75%, Missing); hypothalamus: 50.8772% (minimum 75%, Missing); kidney: 42.6471% (minimum 75%, Missing); liver: 42.6471% (minimum 75%, Missing); lung: 20.7143% (minimum 75%, Missing); lymph node: 69.0476% (minimum 70%, Missing); midbrain: 36.7089% (minimum 75%, Missing); pancreas: 74.3590% (minimum 75%, Missing); retina: 38.6667% (minimum 75%, Missing); salivary gland: 59.1837% (minimum 70%, Missing); skin: 59.1837% (minimum 65%, Missing); small intestine: 48.3333% (minimum 75%, Missing); spinal cord: 37.1795% (minimum 75%, Missing); spleen: 63.0435% (minimum 65%, Missing); stomach: 63.0435% (minimum 70%, Missing)",-0.0581633,-0.267164,-0.542857,0,80,unavailable,11.1,3.8,2,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176771,NCKAP5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.0435% (minimum 65%, Missing); adrenal gland: 74.3590% (minimum 75%, Missing); amygdala: 44.6154% (minimum 75%, Missing); basal ganglia: 41.4286% (minimum 75%, Missing); cerebral cortex: 53.7037% (minimum 75%, Missing); choroid plexus: 60.4167% (minimum 75%, Missing); duodenum: 58.0000% (minimum 75%, Missing); esophagus: 43.2836% (minimum 70%, Missing); heart muscle: 53.7037% (minimum 75%, Missing); hippocampal formation: 40.8451% (minimum 75%, Missing); hypothalamus: 50.8772% (minimum 75%, Missing); kidney: 42.6471% (minimum 75%, Missing); liver: 42.6471% (minimum 75%, Missing); lung: 20.7143% (minimum 75%, Missing); lymph node: 69.0476% (minimum 70%, Missing); midbrain: 36.7089% (minimum 75%, Missing); pancreas: 74.3590% (minimum 75%, Missing); retina: 38.6667% (minimum 75%, Missing); salivary gland: 59.1837% (minimum 70%, Missing); skin: 59.1837% (minimum 65%, Missing); small intestine: 48.3333% (minimum 75%, Missing); spinal cord: 37.1795% (minimum 75%, Missing); spleen: 63.0435% (minimum 65%, Missing); stomach: 63.0435% (minimum 70%, Missing)",-0.0581633,-0.267164,-0.542857,0,80,unavailable,11.1,3.8,2,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176771,NCKAP5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.0435% (minimum 65%, Missing); adrenal gland: 74.3590% (minimum 75%, Missing); amygdala: 44.6154% (minimum 75%, Missing); basal ganglia: 41.4286% (minimum 75%, Missing); cerebral cortex: 53.7037% (minimum 75%, Missing); choroid plexus: 60.4167% (minimum 75%, Missing); duodenum: 58.0000% (minimum 75%, Missing); esophagus: 43.2836% (minimum 70%, Missing); heart muscle: 53.7037% (minimum 75%, Missing); hippocampal formation: 40.8451% (minimum 75%, Missing); hypothalamus: 50.8772% (minimum 75%, Missing); kidney: 42.6471% (minimum 75%, Missing); liver: 42.6471% (minimum 75%, Missing); lung: 20.7143% (minimum 75%, Missing); lymph node: 69.0476% (minimum 70%, Missing); midbrain: 36.7089% (minimum 75%, Missing); pancreas: 74.3590% (minimum 75%, Missing); retina: 38.6667% (minimum 75%, Missing); salivary gland: 59.1837% (minimum 70%, Missing); skin: 59.1837% (minimum 65%, Missing); small intestine: 48.3333% (minimum 75%, Missing); spinal cord: 37.1795% (minimum 75%, Missing); spleen: 63.0435% (minimum 65%, Missing); stomach: 63.0435% (minimum 70%, Missing)",-0.0581633,-0.267164,-0.542857,0,80,unavailable,11.1,3.8,2,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176771,NCKAP5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.0435% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 74.3590% (minimum 75%, Baseline (adaptation disabled)); amygdala: 44.6154% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 41.4286% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.7037% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.4167% (minimum 75%, Baseline (adaptation disabled)); duodenum: 58.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 43.2836% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 53.7037% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 40.8451% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 50.8772% (minimum 75%, Baseline (adaptation disabled)); kidney: 42.6471% (minimum 75%, Baseline (adaptation disabled)); liver: 42.6471% (minimum 75%, Baseline (adaptation disabled)); lung: 20.7143% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.0476% (minimum 70%, Baseline (adaptation disabled)); midbrain: 36.7089% (minimum 75%, Baseline (adaptation disabled)); pancreas: 74.3590% (minimum 75%, Baseline (adaptation disabled)); retina: 38.6667% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.1837% (minimum 70%, Baseline (adaptation disabled)); skin: 59.1837% (minimum 65%, Baseline (adaptation disabled)); small intestine: 48.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 37.1795% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.0435% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.0435% (minimum 70%, Baseline (adaptation disabled))",-0.0581633,-0.267164,-0.542857,0,80,unavailable,11.1,3.8,2,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176771,NCKAP5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176774,MAGEB18,admission_only,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176774,MAGEB18,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176774,MAGEB18,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176774,MAGEB18,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176774,MAGEB18,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,2,partial,0,1.6,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000176782,DEFB104A,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,1.6,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000176782,DEFB104A,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,1.6,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000176782,DEFB104A,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,1.6,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000176782,DEFB104A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.298742,0.25,0,2,partial,0,1.6,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000176782,DEFB104A,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176787,OR52E2,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176787,OR52E2,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176787,OR52E2,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176787,OR52E2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176787,OR52E2,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176895,OR51A7,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176895,OR51A7,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176895,OR51A7,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176895,OR51A7,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176895,OR51A7,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176922,OR51S1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176922,OR51S1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176922,OR51S1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176922,OR51S1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176922,OR51S1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8095% (minimum 99%, Missing); basal ganglia: 98.8095% (minimum 99%, Missing); bone marrow: 87.3684% (minimum 99%, Missing); cerebellum: 97.6471% (minimum 99%, Missing); cerebral cortex: 95.4023% (minimum 99%, Missing); colon: 91.2088% (minimum 97%, Missing); duodenum: 98.8095% (minimum 99%, Missing); heart muscle: 96.5116% (minimum 99%, Missing); hippocampal formation: 97.6471% (minimum 99%, Missing); hypothalamus: 98.8095% (minimum 99%, Missing); kidney: 96.5116% (minimum 99%, Missing); lung: 98.8095% (minimum 99%, Missing); lymph node: 95.4023% (minimum 97%, Missing); midbrain: 96.5116% (minimum 99%, Missing); rectum: 88.2979% (minimum 97%, Missing); retina: 98.8095% (minimum 99%, Missing); skeletal muscle: 98.8095% (minimum 99%, Missing); small intestine: 95.4023% (minimum 99%, Missing); smooth muscle: 97.6471% (minimum 99%, Missing); spinal cord: 98.8095% (minimum 99%, Missing)",0.0264706,-0.0870213,-0.116316,0,80,unavailable,1.2,1.1,0.2,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176927,EFCAB5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326471,0.182979,0.123684,0,80,unavailable,1.2,1.1,0.2,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176927,EFCAB5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326471,0.182979,0.123684,0,80,unavailable,1.2,1.1,0.2,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176927,EFCAB5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326471,0.182979,0.123684,0,80,unavailable,1.2,1.1,0.2,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176927,EFCAB5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326471,0.182979,0.123684,0,80,unavailable,1.2,1.1,0.2,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176927,EFCAB5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 93.7500% (minimum 95%, Uncertain)",-0.0125,0.03,0.01,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176979,TRIM60,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.2875,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176979,TRIM60,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.2875,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176979,TRIM60,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.2875,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176979,TRIM60,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.2875,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176979,TRIM60,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00823322,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176988,FMR1NB,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248233,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176988,FMR1NB,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248233,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176988,FMR1NB,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248233,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176988,FMR1NB,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248233,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000176988,FMR1NB,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,unresolved_reproductive_selectivity;existing_nomination_or_manual_review,True,True,True,,,,,0,0,routine_complete,0,0.2,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000177023,DEFB104B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,unresolved_reproductive_selectivity;existing_nomination_or_manual_review,True,True,True,,,,,0,0,routine_complete,0,0.2,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000177023,DEFB104B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,unresolved_reproductive_selectivity;existing_nomination_or_manual_review,True,True,True,,,,,0,0,routine_complete,0,0.2,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000177023,DEFB104B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,unresolved_reproductive_selectivity;existing_nomination_or_manual_review,True,True,True,,,,,0,0,routine_complete,0,0.2,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000177023,DEFB104B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,unresolved_reproductive_selectivity;existing_nomination_or_manual_review,True,True,True,,,,,0,0,routine_complete,0,0.2,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000177023,DEFB104B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.2256% (minimum 95%, Missing); adrenal gland: 86.9565% (minimum 98%, Approved); amygdala: 86.9565% (minimum 99%, Missing); basal ganglia: 84.5070% (minimum 99%, Missing); bone marrow: 95.2381% (minimum 98%, Approved); cerebellum: 93.7500% (minimum 98%, Approved); cerebral cortex: 90.9091% (minimum 98%, Approved); choroid plexus: 43.4783% (minimum 99%, Missing); colon: 86.3309% (minimum 95%, Approved); duodenum: 93.7500% (minimum 98%, Approved); heart muscle: 71.8563% (minimum 98%, Approved); hippocampal formation: 83.9161% (minimum 99%, Missing); hypothalamus: 83.3333% (minimum 99%, Missing); kidney: 83.3333% (minimum 98%, Approved); liver: 87.5912% (minimum 98%, Approved); lung: 92.3077% (minimum 98%, Approved); midbrain: 82.7586% (minimum 99%, Missing); pancreas: 91.6031% (minimum 98%, Approved); parathyroid gland: 93.0233% (minimum 95%, Approved); pituitary gland: 75.9494% (minimum 99%, Missing); rectum: 93.7500% (minimum 95%, Approved); retina: 70.5882% (minimum 99%, Missing); salivary gland: 90.9091% (minimum 95%, Approved); skeletal muscle: 77.4194% (minimum 98%, Approved); small intestine: 91.6031% (minimum 98%, Approved); smooth muscle: 93.0233% (minimum 98%, Approved); spinal cord: 80.0000% (minimum 99%, Missing); stomach: 92.3077% (minimum 95%, Approved); thyroid gland: 87.5912% (minimum 95%, Missing); tongue: 96.0000% (minimum 97%, Missing); urinary bladder: 88.2353% (minimum 95%, Approved)",-0.0740876,-0.0866906,-0.555217,0,6,partial,15.6,1.9,1.7,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177025,C19orf18,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 43.4783% (minimum 75%, Missing); retina: 70.5882% (minimum 75%, Missing)",0.225912,0.213309,-0.315217,0,6,partial,15.6,1.9,1.7,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177025,C19orf18,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 43.4783% (minimum 75%, Missing); retina: 70.5882% (minimum 75%, Missing)",0.225912,0.213309,-0.315217,0,6,partial,15.6,1.9,1.7,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177025,C19orf18,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 43.4783% (minimum 75%, Missing); retina: 70.5882% (minimum 75%, Missing)",0.225912,0.213309,-0.315217,0,6,partial,15.6,1.9,1.7,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177025,C19orf18,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 43.4783% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.8563% (minimum 75%, Baseline (adaptation disabled)); retina: 70.5882% (minimum 75%, Baseline (adaptation disabled))",0.225912,0.163309,-0.315217,0,6,partial,15.6,1.9,1.7,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177025,C19orf18,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.0000% (minimum 95%, Uncertain); adrenal gland: 92.2314% (minimum 99%, Missing); amygdala: 94.4162% (minimum 99%, Missing); basal ganglia: 93.7815% (minimum 99%, Missing); bone marrow: 88.8535% (minimum 99%, Uncertain); cerebellum: 92.0792% (minimum 99%, Missing); cerebral cortex: 92.0792% (minimum 99%, Uncertain); choroid plexus: 95.0596% (minimum 99%, Missing); colon: 85.9784% (minimum 97%, Missing); duodenum: 87.7358% (minimum 99%, Missing); esophagus: 87.3239% (minimum 97%, Missing); heart muscle: 93.7815% (minimum 99%, Uncertain); hippocampal formation: 93.6242% (minimum 99%, Missing); hypothalamus: 93.4673% (minimum 99%, Missing); kidney: 88.7122% (minimum 99%, Uncertain); liver: 77.6078% (minimum 99%, Missing); lung: 87.8740% (minimum 99%, Uncertain); lymph node: 83.6582% (minimum 97%, Missing); midbrain: 93.9394% (minimum 99%, Missing); pancreas: 82.5444% (minimum 99%, Missing); parathyroid gland: 84.4175% (minimum 97%, Uncertain); pituitary gland: 94.5763% (minimum 99%, Missing); rectum: 85.5828% (minimum 97%, Missing); retina: 85.3211% (minimum 99%, Missing); salivary gland: 90.0000% (minimum 97%, Uncertain); skeletal muscle: 93.0000% (minimum 99%, Uncertain); skin: 88.2911% (minimum 95%, Missing); small intestine: 89.7106% (minimum 99%, Missing); smooth muscle: 87.1875% (minimum 99%, Uncertain); spinal cord: 93.3110% (minimum 99%, Missing); spleen: 87.3239% (minimum 95%, Uncertain); stomach: 87.5981% (minimum 97%, Uncertain); thymus: 86.6460% (minimum 95%, Missing); thyroid gland: 88.2911% (minimum 95%, Uncertain); tongue: 93.7815% (minimum 97%, Missing); urinary bladder: 87.3239% (minimum 97%, Uncertain)",-0.0835404,-0.133418,-0.213922,0,7,partial,16.1,10.9,8.6,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.3 nTPM (protected, limit 2); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); colon: 9.1 nTPM (protected, limit 2); thymus: 8.6 nTPM (manageable, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); urinary bladder: 8.1 nTPM (protected, limit 2); spleen: 8.1 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 2); stomach: 7.9 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); skin: 7.4 nTPM (manageable, limit 5); thyroid gland: 7.4 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); salivary gland: 6.2 nTPM (protected, limit 2); adipose tissue: 6.2 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177058,SLC38A9,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.21646,0.136582,0.0260779,0,7,partial,16.1,10.9,8.6,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.3 nTPM (protected, limit 2); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); colon: 9.1 nTPM (protected, limit 2); thymus: 8.6 nTPM (manageable, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); urinary bladder: 8.1 nTPM (protected, limit 2); spleen: 8.1 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 2); stomach: 7.9 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); skin: 7.4 nTPM (manageable, limit 5); thyroid gland: 7.4 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); salivary gland: 6.2 nTPM (protected, limit 2); adipose tissue: 6.2 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177058,SLC38A9,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.21646,0.136582,0.0260779,0,7,partial,16.1,10.9,8.6,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.3 nTPM (protected, limit 3); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); colon: 9.1 nTPM (protected, limit 3); thymus: 8.6 nTPM (manageable, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); urinary bladder: 8.1 nTPM (protected, limit 3); spleen: 8.1 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 3); stomach: 7.9 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); skin: 7.4 nTPM (manageable, limit 5); thyroid gland: 7.4 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); salivary gland: 6.2 nTPM (protected, limit 3); adipose tissue: 6.2 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177058,SLC38A9,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.21646,0.136582,0.0260779,0,7,partial,16.1,10.9,8.6,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.3 nTPM (protected, limit 3); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); colon: 9.1 nTPM (protected, limit 3); thymus: 8.6 nTPM (manageable, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); urinary bladder: 8.1 nTPM (protected, limit 3); spleen: 8.1 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 3); stomach: 7.9 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); skin: 7.4 nTPM (manageable, limit 5); thyroid gland: 7.4 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); salivary gland: 6.2 nTPM (protected, limit 3); adipose tissue: 6.2 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177058,SLC38A9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.21646,0.136582,0.0260779,0,7,partial,16.1,10.9,8.6,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.3 nTPM (protected, limit 3); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); colon: 9.1 nTPM (protected, limit 3); thymus: 8.6 nTPM (manageable, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); urinary bladder: 8.1 nTPM (protected, limit 3); spleen: 8.1 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 3); stomach: 7.9 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); skin: 7.4 nTPM (manageable, limit 5); thyroid gland: 7.4 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); salivary gland: 6.2 nTPM (protected, limit 3); adipose tissue: 6.2 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177058,SLC38A9,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2759% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); colon: 96.6102% (minimum 97%, Missing); hypothalamus: 98.2759% (minimum 99%, Missing); liver: 65.5172% (minimum 99%, Missing); lung: 98.2759% (minimum 99%, Missing); pancreas: 96.6102% (minimum 99%, Missing); retina: 98.2759% (minimum 99%, Missing); skeletal muscle: 98.2759% (minimum 99%, Missing); small intestine: 95.0000% (minimum 99%, Missing); smooth muscle: 87.6923% (minimum 99%, Missing); spleen: 93.4426% (minimum 95%, Missing)",-0.0155738,-0.00389831,-0.334828,0,80,unavailable,3,0.2,0.4,"liver: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177138,FAM9B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 65.5172% (minimum 75%, Missing)",0.284426,0.266102,-0.0948276,0,80,unavailable,3,0.2,0.4,"liver: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177138,FAM9B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 65.5172% (minimum 75%, Missing)",0.284426,0.266102,-0.0948276,0,80,unavailable,3,0.2,0.4,"liver: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177138,FAM9B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 65.5172% (minimum 75%, Missing)",0.284426,0.266102,-0.0948276,0,80,unavailable,3,0.2,0.4,"liver: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177138,FAM9B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 65.5172% (minimum 75%, Baseline (adaptation disabled))",0.284426,0.266102,-0.0948276,0,80,unavailable,3,0.2,0.4,"liver: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177138,FAM9B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177143,CETN1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177143,CETN1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177143,CETN1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177143,CETN1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177143,CETN1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,3,3.5,1.3,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177202,SPACA4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,3,3.5,1.3,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177202,SPACA4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,3,3.5,1.3,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177202,SPACA4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,3,3.5,1.3,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177202,SPACA4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338774,0.270339,0.224468,0,1,partial,3,3.5,1.3,"colon: 3.5 nTPM (protected, limit 3); stomach: 3.4 nTPM (protected, limit 3); small intestine: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177202,SPACA4,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 90%, Approved); amygdala: 50.0000% (minimum 99%, Missing); basal ganglia: 25.0000% (minimum 99%, Missing); cerebellum: 33.3333% (minimum 99%, Missing); cerebral cortex: 37.5000% (minimum 99%, Missing); colon: 33.3333% (minimum 95%, Approved); esophagus: 75.0000% (minimum 95%, Approved); heart muscle: 60.0000% (minimum 98%, Approved); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 21.4286% (minimum 99%, Missing); kidney: 60.0000% (minimum 98%, Approved); liver: 60.0000% (minimum 98%, Approved); lung: 12.5000% (minimum 98%, Approved); midbrain: 60.0000% (minimum 99%, Missing); pancreas: 75.0000% (minimum 98%, Approved); pituitary gland: 42.8571% (minimum 99%, Missing); salivary gland: 27.2727% (minimum 95%, Approved); skin: 75.0000% (minimum 90%, Approved); small intestine: 13.6364% (minimum 98%, Approved); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 10.7143% (minimum 90%, Approved); stomach: 42.8571% (minimum 95%, Approved); thyroid gland: 37.5000% (minimum 90%, Approved); urinary bladder: 60.0000% (minimum 95%, Approved)",-0.792857,-0.677273,-0.855,0,0,routine_complete,2.1,0.8,2.5,"lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177272,KCNA3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 60%, Approved); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 25.0000% (minimum 75%, Missing); cerebellum: 33.3333% (minimum 75%, Missing); cerebral cortex: 37.5000% (minimum 75%, Missing); colon: 33.3333% (minimum 65%, Approved); heart muscle: 60.0000% (minimum 70%, Approved); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 21.4286% (minimum 75%, Missing); kidney: 60.0000% (minimum 70%, Approved); liver: 60.0000% (minimum 70%, Approved); lung: 12.5000% (minimum 70%, Approved); midbrain: 60.0000% (minimum 75%, Missing); pituitary gland: 42.8571% (minimum 75%, Missing); salivary gland: 27.2727% (minimum 65%, Approved); small intestine: 13.6364% (minimum 70%, Approved); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 10.7143% (minimum 60%, Approved); stomach: 42.8571% (minimum 65%, Approved); thyroid gland: 37.5000% (minimum 60%, Approved); urinary bladder: 60.0000% (minimum 65%, Approved)",-0.492857,-0.377273,-0.575,0,0,routine_complete,2.1,0.8,2.5,"lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177272,KCNA3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 60%, Approved); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 25.0000% (minimum 75%, Missing); cerebellum: 33.3333% (minimum 75%, Missing); cerebral cortex: 37.5000% (minimum 75%, Missing); colon: 33.3333% (minimum 65%, Approved); heart muscle: 60.0000% (minimum 70%, Approved); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 21.4286% (minimum 75%, Missing); kidney: 60.0000% (minimum 70%, Approved); liver: 60.0000% (minimum 70%, Approved); lung: 12.5000% (minimum 70%, Approved); midbrain: 60.0000% (minimum 75%, Missing); pituitary gland: 42.8571% (minimum 75%, Missing); salivary gland: 27.2727% (minimum 65%, Approved); small intestine: 13.6364% (minimum 70%, Approved); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 10.7143% (minimum 60%, Approved); stomach: 42.8571% (minimum 65%, Approved); thyroid gland: 37.5000% (minimum 60%, Approved); urinary bladder: 60.0000% (minimum 65%, Approved)",-0.492857,-0.377273,-0.575,0,0,routine_complete,2.1,0.8,2.5,"lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177272,KCNA3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 60%, Approved); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 25.0000% (minimum 75%, Missing); cerebellum: 33.3333% (minimum 75%, Missing); cerebral cortex: 37.5000% (minimum 75%, Missing); colon: 33.3333% (minimum 65%, Approved); heart muscle: 60.0000% (minimum 70%, Approved); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 21.4286% (minimum 75%, Missing); kidney: 60.0000% (minimum 70%, Approved); liver: 60.0000% (minimum 70%, Approved); lung: 12.5000% (minimum 70%, Approved); midbrain: 60.0000% (minimum 75%, Missing); pituitary gland: 42.8571% (minimum 75%, Missing); salivary gland: 27.2727% (minimum 65%, Approved); small intestine: 13.6364% (minimum 70%, Approved); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 10.7143% (minimum 60%, Approved); stomach: 42.8571% (minimum 65%, Approved); thyroid gland: 37.5000% (minimum 60%, Approved); urinary bladder: 60.0000% (minimum 65%, Approved)",-0.492857,-0.377273,-0.575,0,0,routine_complete,2.1,0.8,2.5,"lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177272,KCNA3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 65%, Baseline (adaptation disabled)); amygdala: 50.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 25.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 33.3333% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 37.5000% (minimum 75%, Baseline (adaptation disabled)); colon: 33.3333% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 21.4286% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 60.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 12.5000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 60.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 42.8571% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 27.2727% (minimum 70%, Baseline (adaptation disabled)); small intestine: 13.6364% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 10.7143% (minimum 65%, Baseline (adaptation disabled)); stomach: 42.8571% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 37.5000% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 70%, Baseline (adaptation disabled))",-0.542857,-0.427273,-0.625,0,0,routine_complete,2.1,0.8,2.5,"lung: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177272,KCNA3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 97.3597% (minimum 99%, Missing)",0.0399329,0.0199329,-0.0164026,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177294,FBXO39,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.339933,0.289933,0.223597,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177294,FBXO39,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.339933,0.289933,0.223597,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177294,FBXO39,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.339933,0.289933,0.223597,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177294,FBXO39,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.339933,0.289933,0.223597,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177294,FBXO39,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0.2,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177324,BEND2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.2,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177324,BEND2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.2,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177324,BEND2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.2,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177324,BEND2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.312963,0.3,0.212963,0,2,partial,0.2,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177324,BEND2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 90.9091% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); liver: 90.9091% (minimum 99%, Missing); lung: 90.9091% (minimum 99%, Missing); lymph node: 90.9091% (minimum 97%, Missing); small intestine: 83.3333% (minimum 99%, Missing); thymus: 76.9231% (minimum 95%, Missing)",-0.180769,-0.0609091,-0.156667,0,80,unavailable,0.2,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177398,UMODL1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.119231,0.209091,0.0833333,0,80,unavailable,0.2,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177398,UMODL1,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.119231,0.209091,0.0833333,0,80,unavailable,0.2,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177398,UMODL1,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.119231,0.209091,0.0833333,0,80,unavailable,0.2,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177398,UMODL1,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.119231,0.209091,0.0833333,0,80,unavailable,0.2,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177398,UMODL1,current_fixed,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 97.6331% (minimum 99%, Missing); kidney: 98.8024% (minimum 99%, Missing); stomach: 93.4844% (minimum 97%, Missing)",0.05,-0.0351558,-0.0136686,0,80,unavailable,0.8,2.3,0,"stomach: 2.3 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177414,UBE2U,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.234844,0.226331,0,80,unavailable,0.8,2.3,0,"stomach: 2.3 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177414,UBE2U,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.234844,0.226331,0,80,unavailable,0.8,2.3,0,,,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177414,UBE2U,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.234844,0.226331,0,80,unavailable,0.8,2.3,0,,,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177414,UBE2U,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.234844,0.226331,0,80,unavailable,0.8,2.3,0,,,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177414,UBE2U,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lung: 98.0769% (minimum 99%, Missing)",0.05,0.0107692,-0.00923077,0,5,partial,0.5,0.3,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177483,RBM44,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.280769,0.230769,0,5,partial,0.5,0.3,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177483,RBM44,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.280769,0.230769,0,5,partial,0.5,0.3,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177483,RBM44,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.280769,0.230769,0,5,partial,0.5,0.3,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177483,RBM44,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.330769,0.280769,0.218354,0,5,partial,0.5,0.3,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177483,RBM44,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177504,VCX2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177504,VCX2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177504,VCX2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177504,VCX2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177504,VCX2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00850523,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177558,FAM187B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248505,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177558,FAM187B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248505,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177558,FAM187B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248505,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177558,FAM187B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347015,0.3,0.248505,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177558,FAM187B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0474293,0.0197959,0.00232737,0,80,unavailable,0.3,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177627,C12orf54,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347429,0.289796,0.242327,0,80,unavailable,0.3,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177627,C12orf54,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347429,0.289796,0.242327,0,80,unavailable,0.3,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177627,C12orf54,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347429,0.289796,0.242327,0,80,unavailable,0.3,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177627,C12orf54,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347429,0.289796,0.242327,0,80,unavailable,0.3,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177627,C12orf54,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177673,TEX44,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177673,TEX44,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177673,TEX44,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177673,TEX44,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177673,TEX44,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000177684,DEFB114,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000177684,DEFB114,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000177684,DEFB114,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000177684,DEFB114,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000177684,DEFB114,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 88.8889% (minimum 99%, Missing); cerebral cortex: 96.0000% (minimum 99%, Missing); lymph node: 96.0000% (minimum 97%, Missing); retina: 96.0000% (minimum 99%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); skin: 92.3077% (minimum 95%, Missing); stomach: 96.0000% (minimum 97%, Missing)",-0.0269231,-0.01,-0.101111,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177689,MAGEB10,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.273077,0.26,0.138889,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177689,MAGEB10,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.273077,0.26,0.138889,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177689,MAGEB10,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.273077,0.26,0.138889,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177689,MAGEB10,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.273077,0.26,0.138889,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177689,MAGEB10,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.8919% (minimum 95%, Missing); adrenal gland: 75.5556% (minimum 99%, Missing); amygdala: 79.0698% (minimum 99%, Missing); basal ganglia: 76.4045% (minimum 99%, Missing); bone marrow: 94.4444% (minimum 99%, Missing); cerebellum: 72.3404% (minimum 99%, Missing); cerebral cortex: 71.5789% (minimum 99%, Missing); choroid plexus: 88.3117% (minimum 99%, Missing); colon: 86.0759% (minimum 97%, Missing); duodenum: 95.7746% (minimum 99%, Missing); esophagus: 86.0759% (minimum 97%, Missing); heart muscle: 70.8333% (minimum 99%, Missing); hippocampal formation: 76.4045% (minimum 99%, Missing); hypothalamus: 77.2727% (minimum 99%, Missing); kidney: 73.1183% (minimum 99%, Missing); liver: 73.1183% (minimum 99%, Missing); lung: 91.8919% (minimum 99%, Missing); midbrain: 78.1609% (minimum 99%, Missing); pancreas: 83.9506% (minimum 99%, Missing); parathyroid gland: 83.9506% (minimum 97%, Missing); pituitary gland: 82.9268% (minimum 99%, Missing); rectum: 91.8919% (minimum 97%, Missing); retina: 80.9524% (minimum 99%, Missing); salivary gland: 82.9268% (minimum 97%, Missing); skeletal muscle: 71.5789% (minimum 99%, Missing); skin: 91.8919% (minimum 95%, Missing); small intestine: 86.0759% (minimum 99%, Missing); smooth muscle: 95.7746% (minimum 99%, Missing); spinal cord: 80.9524% (minimum 99%, Missing); spleen: 86.0759% (minimum 95%, Missing); stomach: 81.9277% (minimum 97%, Missing); thyroid gland: 73.9130% (minimum 95%, Missing); tongue: 78.1609% (minimum 97%, Missing); urinary bladder: 91.8919% (minimum 97%, Missing)",-0.21087,-0.188391,-0.281667,0,0,routine_complete,2.8,1.9,2.4,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177692,DNAJC28,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 72.3404% (minimum 75%, Missing); cerebral cortex: 71.5789% (minimum 75%, Missing); heart muscle: 70.8333% (minimum 75%, Missing); kidney: 73.1183% (minimum 75%, Missing); liver: 73.1183% (minimum 75%, Missing); skeletal muscle: 71.5789% (minimum 75%, Missing)",0.0891304,0.0816092,-0.0416667,0,0,routine_complete,2.8,1.9,2.4,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177692,DNAJC28,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 72.3404% (minimum 75%, Missing); cerebral cortex: 71.5789% (minimum 75%, Missing); heart muscle: 70.8333% (minimum 75%, Missing); kidney: 73.1183% (minimum 75%, Missing); liver: 73.1183% (minimum 75%, Missing); skeletal muscle: 71.5789% (minimum 75%, Missing)",0.0891304,0.0816092,-0.0416667,0,0,routine_complete,2.8,1.9,2.4,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177692,DNAJC28,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 72.3404% (minimum 75%, Missing); cerebral cortex: 71.5789% (minimum 75%, Missing); heart muscle: 70.8333% (minimum 75%, Missing); kidney: 73.1183% (minimum 75%, Missing); liver: 73.1183% (minimum 75%, Missing); skeletal muscle: 71.5789% (minimum 75%, Missing)",0.0891304,0.0816092,-0.0416667,0,0,routine_complete,2.8,1.9,2.4,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177692,DNAJC28,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 72.3404% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 71.5789% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.8333% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.1183% (minimum 75%, Baseline (adaptation disabled)); liver: 73.1183% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 71.5789% (minimum 75%, Baseline (adaptation disabled))",0.0891304,0.0816092,-0.0416667,0,0,routine_complete,2.8,1.9,2.4,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177692,DNAJC28,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.6190% (minimum 95%, Missing); adrenal gland: 85.9155% (minimum 98%, Approved); amygdala: 93.8462% (minimum 99%, Missing); basal ganglia: 93.8462% (minimum 99%, Missing); bone marrow: 96.8254% (minimum 98%, Approved); cerebellum: 96.8254% (minimum 98%, Approved); cerebral cortex: 85.9155% (minimum 99%, Missing); choroid plexus: 96.8254% (minimum 99%, Missing); colon: 67.7778% (minimum 97%, Missing); duodenum: 79.2208% (minimum 98%, Approved); esophagus: 80.2632% (minimum 95%, Approved); heart muscle: 70.9302% (minimum 98%, Approved); hippocampal formation: 93.8462% (minimum 99%, Missing); hypothalamus: 95.3125% (minimum 99%, Missing); kidney: 65.5914% (minimum 99%, Missing); liver: 68.5393% (minimum 98%, Approved); lung: 76.2500% (minimum 99%, Missing); lymph node: 92.4242% (minimum 95%, Approved); midbrain: 93.8462% (minimum 99%, Missing); pancreas: 74.3902% (minimum 99%, Missing); parathyroid gland: 38.1250% (minimum 97%, Missing); pituitary gland: 92.4242% (minimum 99%, Missing); rectum: 72.6190% (minimum 97%, Missing); retina: 80.2632% (minimum 99%, Missing); salivary gland: 52.1368% (minimum 97%, Missing); skeletal muscle: 87.1429% (minimum 99%, Missing); skin: 89.7059% (minimum 95%, Missing); small intestine: 79.2208% (minimum 98%, Approved); smooth muscle: 64.2105% (minimum 98%, Approved); spinal cord: 89.7059% (minimum 99%, Missing); spleen: 76.2500% (minimum 90%, Approved); stomach: 70.1149% (minimum 95%, Approved); thymus: 84.7222% (minimum 95%, Missing); thyroid gland: 73.4940% (minimum 90%, Approved); tongue: 79.2208% (minimum 97%, Missing); urinary bladder: 62.2449% (minimum 97%, Missing)",-0.22381,-0.58875,-0.337895,0,8,partial,3.4,9.9,2.3,"parathyroid gland: 9.9 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 2); kidney: 3.2 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 2); heart muscle: 2.5 nTPM (vital, limit 2); rectum: 2.3 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177694,NAALADL2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 67.7778% (minimum 70%, Missing); kidney: 65.5914% (minimum 75%, Missing); liver: 68.5393% (minimum 70%, Approved); pancreas: 74.3902% (minimum 75%, Missing); parathyroid gland: 38.1250% (minimum 70%, Missing); salivary gland: 52.1368% (minimum 70%, Missing); smooth muscle: 64.2105% (minimum 70%, Approved); urinary bladder: 62.2449% (minimum 70%, Missing)",0.0761905,-0.31875,-0.094086,0,8,partial,3.4,9.9,2.3,"parathyroid gland: 9.9 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 2); kidney: 3.2 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 2); heart muscle: 2.5 nTPM (vital, limit 2); rectum: 2.3 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177694,NAALADL2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 67.7778% (minimum 70%, Missing); kidney: 65.5914% (minimum 75%, Missing); liver: 68.5393% (minimum 70%, Approved); pancreas: 74.3902% (minimum 75%, Missing); parathyroid gland: 38.1250% (minimum 70%, Missing); salivary gland: 52.1368% (minimum 70%, Missing); smooth muscle: 64.2105% (minimum 70%, Approved); urinary bladder: 62.2449% (minimum 70%, Missing)",0.0761905,-0.31875,-0.094086,0,8,partial,3.4,9.9,2.3,"parathyroid gland: 9.9 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 2); kidney: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 2); heart muscle: 2.5 nTPM (vital, limit 2); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177694,NAALADL2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 67.7778% (minimum 70%, Missing); kidney: 65.5914% (minimum 75%, Missing); liver: 68.5393% (minimum 70%, Approved); pancreas: 74.3902% (minimum 75%, Missing); parathyroid gland: 38.1250% (minimum 70%, Missing); salivary gland: 52.1368% (minimum 70%, Missing); smooth muscle: 64.2105% (minimum 70%, Approved); urinary bladder: 62.2449% (minimum 70%, Missing)",0.0761905,-0.31875,-0.094086,0,8,partial,3.4,9.9,2.3,"parathyroid gland: 9.9 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 2); kidney: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 2); heart muscle: 2.5 nTPM (vital, limit 2); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177694,NAALADL2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 67.7778% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.9302% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.5914% (minimum 75%, Baseline (adaptation disabled)); liver: 68.5393% (minimum 75%, Baseline (adaptation disabled)); pancreas: 74.3902% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 38.1250% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 52.1368% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 64.2105% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 62.2449% (minimum 70%, Baseline (adaptation disabled))",0.0761905,-0.31875,-0.107895,0,8,partial,3.4,9.9,2.3,"parathyroid gland: 9.9 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177694,NAALADL2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.8571% (minimum 95%, Missing); adrenal gland: 73.0769% (minimum 99%, Missing); amygdala: 65.5172% (minimum 99%, Missing); basal ganglia: 73.0769% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 65.5172% (minimum 99%, Missing); cerebral cortex: 31.1475% (minimum 99%, Missing); choroid plexus: 82.6087% (minimum 99%, Missing); colon: 65.5172% (minimum 97%, Missing); duodenum: 95.0000% (minimum 99%, Missing); esophagus: 86.3636% (minimum 97%, Missing); heart muscle: 63.3333% (minimum 99%, Missing); hippocampal formation: 67.8571% (minimum 99%, Missing); hypothalamus: 73.0769% (minimum 99%, Missing); kidney: 79.1667% (minimum 99%, Missing); liver: 90.4762% (minimum 99%, Missing); lung: 63.3333% (minimum 99%, Missing); lymph node: 95.0000% (minimum 97%, Missing); midbrain: 76.0000% (minimum 99%, Missing); pancreas: 73.0769% (minimum 99%, Missing); parathyroid gland: 63.3333% (minimum 97%, Missing); pituitary gland: 44.1860% (minimum 99%, Missing); rectum: 90.4762% (minimum 97%, Missing); retina: 61.2903% (minimum 99%, Missing); salivary gland: 65.5172% (minimum 97%, Missing); skeletal muscle: 82.6087% (minimum 99%, Missing); skin: 73.0769% (minimum 95%, Missing); small intestine: 82.6087% (minimum 99%, Missing); smooth muscle: 63.3333% (minimum 99%, Missing); spinal cord: 73.0769% (minimum 99%, Missing); spleen: 86.3636% (minimum 95%, Missing); stomach: 82.6087% (minimum 97%, Missing); thyroid gland: 76.0000% (minimum 95%, Missing); tongue: 67.8571% (minimum 97%, Missing); urinary bladder: 70.3704% (minimum 97%, Missing)",-0.271429,-0.336667,-0.678525,0,6,partial,4.2,1.1,0.9,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177839,PCDHB9,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.0769% (minimum 75%, Missing); amygdala: 65.5172% (minimum 75%, Missing); basal ganglia: 73.0769% (minimum 75%, Missing); cerebellum: 65.5172% (minimum 75%, Missing); cerebral cortex: 31.1475% (minimum 75%, Missing); colon: 65.5172% (minimum 70%, Missing); heart muscle: 63.3333% (minimum 75%, Missing); hippocampal formation: 67.8571% (minimum 75%, Missing); hypothalamus: 73.0769% (minimum 75%, Missing); lung: 63.3333% (minimum 75%, Missing); pancreas: 73.0769% (minimum 75%, Missing); parathyroid gland: 63.3333% (minimum 70%, Missing); pituitary gland: 44.1860% (minimum 75%, Missing); retina: 61.2903% (minimum 75%, Missing); salivary gland: 65.5172% (minimum 70%, Missing); smooth muscle: 63.3333% (minimum 75%, Missing); spinal cord: 73.0769% (minimum 75%, Missing); tongue: 67.8571% (minimum 70%, Missing)",0.0285714,-0.0666667,-0.438525,0,6,partial,4.2,1.1,0.9,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177839,PCDHB9,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.0769% (minimum 75%, Missing); amygdala: 65.5172% (minimum 75%, Missing); basal ganglia: 73.0769% (minimum 75%, Missing); cerebellum: 65.5172% (minimum 75%, Missing); cerebral cortex: 31.1475% (minimum 75%, Missing); colon: 65.5172% (minimum 70%, Missing); heart muscle: 63.3333% (minimum 75%, Missing); hippocampal formation: 67.8571% (minimum 75%, Missing); hypothalamus: 73.0769% (minimum 75%, Missing); lung: 63.3333% (minimum 75%, Missing); pancreas: 73.0769% (minimum 75%, Missing); parathyroid gland: 63.3333% (minimum 70%, Missing); pituitary gland: 44.1860% (minimum 75%, Missing); retina: 61.2903% (minimum 75%, Missing); salivary gland: 65.5172% (minimum 70%, Missing); smooth muscle: 63.3333% (minimum 75%, Missing); spinal cord: 73.0769% (minimum 75%, Missing); tongue: 67.8571% (minimum 70%, Missing)",0.0285714,-0.0666667,-0.438525,0,6,partial,4.2,1.1,0.9,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177839,PCDHB9,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.0769% (minimum 75%, Missing); amygdala: 65.5172% (minimum 75%, Missing); basal ganglia: 73.0769% (minimum 75%, Missing); cerebellum: 65.5172% (minimum 75%, Missing); cerebral cortex: 31.1475% (minimum 75%, Missing); colon: 65.5172% (minimum 70%, Missing); heart muscle: 63.3333% (minimum 75%, Missing); hippocampal formation: 67.8571% (minimum 75%, Missing); hypothalamus: 73.0769% (minimum 75%, Missing); lung: 63.3333% (minimum 75%, Missing); pancreas: 73.0769% (minimum 75%, Missing); parathyroid gland: 63.3333% (minimum 70%, Missing); pituitary gland: 44.1860% (minimum 75%, Missing); retina: 61.2903% (minimum 75%, Missing); salivary gland: 65.5172% (minimum 70%, Missing); smooth muscle: 63.3333% (minimum 75%, Missing); spinal cord: 73.0769% (minimum 75%, Missing); tongue: 67.8571% (minimum 70%, Missing)",0.0285714,-0.0666667,-0.438525,0,6,partial,4.2,1.1,0.9,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177839,PCDHB9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.0769% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.5172% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.0769% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.5172% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 31.1475% (minimum 75%, Baseline (adaptation disabled)); colon: 65.5172% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.3333% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.8571% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.0769% (minimum 75%, Baseline (adaptation disabled)); lung: 63.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.0769% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.3333% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 44.1860% (minimum 75%, Baseline (adaptation disabled)); retina: 61.2903% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.5172% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 63.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.0769% (minimum 75%, Baseline (adaptation disabled)); tongue: 67.8571% (minimum 70%, Baseline (adaptation disabled))",0.0285714,-0.0666667,-0.438525,0,6,partial,4.2,1.1,0.9,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177839,PCDHB9,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.8571% (minimum 95%, Missing); adrenal gland: 55.0000% (minimum 99%, Missing); amygdala: 61.1111% (minimum 99%, Missing); basal ganglia: 57.8947% (minimum 99%, Missing); bone marrow: 41.5094% (minimum 99%, Missing); cerebellum: 40.7407% (minimum 99%, Missing); cerebral cortex: 48.8889% (minimum 99%, Missing); choroid plexus: 61.1111% (minimum 99%, Missing); colon: 55.0000% (minimum 97%, Missing); duodenum: 57.8947% (minimum 99%, Missing); esophagus: 68.7500% (minimum 97%, Missing); heart muscle: 57.8947% (minimum 99%, Missing); hippocampal formation: 61.1111% (minimum 99%, Missing); hypothalamus: 59.4595% (minimum 99%, Missing); kidney: 48.8889% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Missing); lung: 51.1628% (minimum 99%, Missing); lymph node: 64.7059% (minimum 97%, Missing); midbrain: 57.8947% (minimum 99%, Missing); pancreas: 47.8261% (minimum 99%, Missing); parathyroid gland: 45.8333% (minimum 97%, Missing); pituitary gland: 47.8261% (minimum 99%, Missing); rectum: 51.1628% (minimum 97%, Missing); retina: 34.9206% (minimum 99%, Missing); salivary gland: 68.7500% (minimum 97%, Missing); skeletal muscle: 46.8085% (minimum 99%, Missing); skin: 75.8621% (minimum 95%, Missing); small intestine: 59.4595% (minimum 99%, Missing); smooth muscle: 59.4595% (minimum 99%, Missing); spinal cord: 59.4595% (minimum 99%, Missing); spleen: 56.4103% (minimum 95%, Missing); stomach: 45.8333% (minimum 97%, Missing); thymus: 59.4595% (minimum 95%, Missing); thyroid gland: 40.0000% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 62.8571% (minimum 97%, Missing)",-0.55,-0.511667,-0.640794,0,80,unavailable,4.1,2.6,3.3,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177842,ZNF620,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.8571% (minimum 65%, Missing); adrenal gland: 55.0000% (minimum 75%, Missing); amygdala: 61.1111% (minimum 75%, Missing); basal ganglia: 57.8947% (minimum 75%, Missing); bone marrow: 41.5094% (minimum 75%, Missing); cerebellum: 40.7407% (minimum 75%, Missing); cerebral cortex: 48.8889% (minimum 75%, Missing); choroid plexus: 61.1111% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 57.8947% (minimum 75%, Missing); esophagus: 68.7500% (minimum 70%, Missing); heart muscle: 57.8947% (minimum 75%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 59.4595% (minimum 75%, Missing); kidney: 48.8889% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 51.1628% (minimum 75%, Missing); lymph node: 64.7059% (minimum 70%, Missing); midbrain: 57.8947% (minimum 75%, Missing); pancreas: 47.8261% (minimum 75%, Missing); parathyroid gland: 45.8333% (minimum 70%, Missing); pituitary gland: 47.8261% (minimum 75%, Missing); rectum: 51.1628% (minimum 70%, Missing); retina: 34.9206% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skeletal muscle: 46.8085% (minimum 75%, Missing); small intestine: 59.4595% (minimum 75%, Missing); smooth muscle: 59.4595% (minimum 75%, Missing); spinal cord: 59.4595% (minimum 75%, Missing); spleen: 56.4103% (minimum 65%, Missing); stomach: 45.8333% (minimum 70%, Missing); thymus: 59.4595% (minimum 65%, Missing); thyroid gland: 40.0000% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 62.8571% (minimum 70%, Missing)",-0.25,-0.241667,-0.400794,0,80,unavailable,4.1,2.6,3.3,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177842,ZNF620,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.8571% (minimum 65%, Missing); adrenal gland: 55.0000% (minimum 75%, Missing); amygdala: 61.1111% (minimum 75%, Missing); basal ganglia: 57.8947% (minimum 75%, Missing); bone marrow: 41.5094% (minimum 75%, Missing); cerebellum: 40.7407% (minimum 75%, Missing); cerebral cortex: 48.8889% (minimum 75%, Missing); choroid plexus: 61.1111% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 57.8947% (minimum 75%, Missing); esophagus: 68.7500% (minimum 70%, Missing); heart muscle: 57.8947% (minimum 75%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 59.4595% (minimum 75%, Missing); kidney: 48.8889% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 51.1628% (minimum 75%, Missing); lymph node: 64.7059% (minimum 70%, Missing); midbrain: 57.8947% (minimum 75%, Missing); pancreas: 47.8261% (minimum 75%, Missing); parathyroid gland: 45.8333% (minimum 70%, Missing); pituitary gland: 47.8261% (minimum 75%, Missing); rectum: 51.1628% (minimum 70%, Missing); retina: 34.9206% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skeletal muscle: 46.8085% (minimum 75%, Missing); small intestine: 59.4595% (minimum 75%, Missing); smooth muscle: 59.4595% (minimum 75%, Missing); spinal cord: 59.4595% (minimum 75%, Missing); spleen: 56.4103% (minimum 65%, Missing); stomach: 45.8333% (minimum 70%, Missing); thymus: 59.4595% (minimum 65%, Missing); thyroid gland: 40.0000% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 62.8571% (minimum 70%, Missing)",-0.25,-0.241667,-0.400794,0,80,unavailable,4.1,2.6,3.3,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177842,ZNF620,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.8571% (minimum 65%, Missing); adrenal gland: 55.0000% (minimum 75%, Missing); amygdala: 61.1111% (minimum 75%, Missing); basal ganglia: 57.8947% (minimum 75%, Missing); bone marrow: 41.5094% (minimum 75%, Missing); cerebellum: 40.7407% (minimum 75%, Missing); cerebral cortex: 48.8889% (minimum 75%, Missing); choroid plexus: 61.1111% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 57.8947% (minimum 75%, Missing); esophagus: 68.7500% (minimum 70%, Missing); heart muscle: 57.8947% (minimum 75%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 59.4595% (minimum 75%, Missing); kidney: 48.8889% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 51.1628% (minimum 75%, Missing); lymph node: 64.7059% (minimum 70%, Missing); midbrain: 57.8947% (minimum 75%, Missing); pancreas: 47.8261% (minimum 75%, Missing); parathyroid gland: 45.8333% (minimum 70%, Missing); pituitary gland: 47.8261% (minimum 75%, Missing); rectum: 51.1628% (minimum 70%, Missing); retina: 34.9206% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skeletal muscle: 46.8085% (minimum 75%, Missing); small intestine: 59.4595% (minimum 75%, Missing); smooth muscle: 59.4595% (minimum 75%, Missing); spinal cord: 59.4595% (minimum 75%, Missing); spleen: 56.4103% (minimum 65%, Missing); stomach: 45.8333% (minimum 70%, Missing); thymus: 59.4595% (minimum 65%, Missing); thyroid gland: 40.0000% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 62.8571% (minimum 70%, Missing)",-0.25,-0.241667,-0.400794,0,80,unavailable,4.1,2.6,3.3,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177842,ZNF620,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.8571% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 55.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 61.1111% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 57.8947% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 41.5094% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 40.7407% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.8889% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 61.1111% (minimum 75%, Baseline (adaptation disabled)); colon: 55.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.8947% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.7500% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 57.8947% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.1111% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 59.4595% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.8889% (minimum 75%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 75%, Baseline (adaptation disabled)); lung: 51.1628% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.7059% (minimum 70%, Baseline (adaptation disabled)); midbrain: 57.8947% (minimum 75%, Baseline (adaptation disabled)); pancreas: 47.8261% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 45.8333% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 47.8261% (minimum 75%, Baseline (adaptation disabled)); rectum: 51.1628% (minimum 70%, Baseline (adaptation disabled)); retina: 34.9206% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.7500% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 46.8085% (minimum 75%, Baseline (adaptation disabled)); small intestine: 59.4595% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.4595% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.4595% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.4103% (minimum 65%, Baseline (adaptation disabled)); stomach: 45.8333% (minimum 70%, Baseline (adaptation disabled)); thymus: 59.4595% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 40.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.8571% (minimum 70%, Baseline (adaptation disabled))",-0.25,-0.241667,-0.400794,0,80,unavailable,4.1,2.6,3.3,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177842,ZNF620,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 95%, Missing); adrenal gland: 63.6364% (minimum 99%, Missing); amygdala: 70.0000% (minimum 99%, Missing); basal ganglia: 68.2927% (minimum 99%, Missing); bone marrow: 48.2759% (minimum 99%, Missing); cerebellum: 65.1163% (minimum 99%, Missing); cerebral cortex: 60.8696% (minimum 99%, Missing); choroid plexus: 71.7949% (minimum 99%, Missing); colon: 58.3333% (minimum 97%, Missing); duodenum: 54.9020% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 62.2222% (minimum 99%, Missing); hippocampal formation: 70.0000% (minimum 99%, Missing); hypothalamus: 71.7949% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); liver: 54.9020% (minimum 99%, Missing); lung: 59.5745% (minimum 99%, Missing); lymph node: 54.9020% (minimum 97%, Missing); midbrain: 68.2927% (minimum 99%, Missing); pancreas: 53.8462% (minimum 99%, Missing); parathyroid gland: 48.2759% (minimum 97%, Missing); pituitary gland: 71.7949% (minimum 99%, Missing); rectum: 52.8302% (minimum 97%, Missing); retina: 41.1765% (minimum 99%, Missing); salivary gland: 51.8519% (minimum 97%, Missing); skeletal muscle: 52.8302% (minimum 99%, Missing); skin: 54.9020% (minimum 95%, Missing); small intestine: 59.5745% (minimum 99%, Missing); smooth muscle: 56.0000% (minimum 99%, Missing); spinal cord: 63.6364% (minimum 99%, Missing); spleen: 49.1228% (minimum 95%, Missing); stomach: 54.9020% (minimum 97%, Missing); thymus: 65.1163% (minimum 95%, Missing); thyroid gland: 49.1228% (minimum 95%, Missing); tongue: 57.1429% (minimum 97%, Missing); urinary bladder: 63.6364% (minimum 97%, Missing)",-0.458772,-0.487241,-0.578235,0,4,partial,4,3,2.9,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); liver: 2.3 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177873,ZNF619,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 68.2927% (minimum 75%, Missing); bone marrow: 48.2759% (minimum 75%, Missing); cerebellum: 65.1163% (minimum 75%, Missing); cerebral cortex: 60.8696% (minimum 75%, Missing); choroid plexus: 71.7949% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 54.9020% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 62.2222% (minimum 75%, Missing); hippocampal formation: 70.0000% (minimum 75%, Missing); hypothalamus: 71.7949% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 54.9020% (minimum 75%, Missing); lung: 59.5745% (minimum 75%, Missing); lymph node: 54.9020% (minimum 70%, Missing); midbrain: 68.2927% (minimum 75%, Missing); pancreas: 53.8462% (minimum 75%, Missing); parathyroid gland: 48.2759% (minimum 70%, Missing); pituitary gland: 71.7949% (minimum 75%, Missing); rectum: 52.8302% (minimum 70%, Missing); retina: 41.1765% (minimum 75%, Missing); salivary gland: 51.8519% (minimum 70%, Missing); skeletal muscle: 52.8302% (minimum 75%, Missing); skin: 54.9020% (minimum 65%, Missing); small intestine: 59.5745% (minimum 75%, Missing); smooth muscle: 56.0000% (minimum 75%, Missing); spinal cord: 63.6364% (minimum 75%, Missing); spleen: 49.1228% (minimum 65%, Missing); stomach: 54.9020% (minimum 70%, Missing); thyroid gland: 49.1228% (minimum 65%, Missing); tongue: 57.1429% (minimum 70%, Missing); urinary bladder: 63.6364% (minimum 70%, Missing)",-0.158772,-0.217241,-0.338235,0,4,partial,4,3,2.9,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); liver: 2.3 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177873,ZNF619,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 68.2927% (minimum 75%, Missing); bone marrow: 48.2759% (minimum 75%, Missing); cerebellum: 65.1163% (minimum 75%, Missing); cerebral cortex: 60.8696% (minimum 75%, Missing); choroid plexus: 71.7949% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 54.9020% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 62.2222% (minimum 75%, Missing); hippocampal formation: 70.0000% (minimum 75%, Missing); hypothalamus: 71.7949% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 54.9020% (minimum 75%, Missing); lung: 59.5745% (minimum 75%, Missing); lymph node: 54.9020% (minimum 70%, Missing); midbrain: 68.2927% (minimum 75%, Missing); pancreas: 53.8462% (minimum 75%, Missing); parathyroid gland: 48.2759% (minimum 70%, Missing); pituitary gland: 71.7949% (minimum 75%, Missing); rectum: 52.8302% (minimum 70%, Missing); retina: 41.1765% (minimum 75%, Missing); salivary gland: 51.8519% (minimum 70%, Missing); skeletal muscle: 52.8302% (minimum 75%, Missing); skin: 54.9020% (minimum 65%, Missing); small intestine: 59.5745% (minimum 75%, Missing); smooth muscle: 56.0000% (minimum 75%, Missing); spinal cord: 63.6364% (minimum 75%, Missing); spleen: 49.1228% (minimum 65%, Missing); stomach: 54.9020% (minimum 70%, Missing); thyroid gland: 49.1228% (minimum 65%, Missing); tongue: 57.1429% (minimum 70%, Missing); urinary bladder: 63.6364% (minimum 70%, Missing)",-0.158772,-0.217241,-0.338235,0,4,partial,4,3,2.9,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177873,ZNF619,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 68.2927% (minimum 75%, Missing); bone marrow: 48.2759% (minimum 75%, Missing); cerebellum: 65.1163% (minimum 75%, Missing); cerebral cortex: 60.8696% (minimum 75%, Missing); choroid plexus: 71.7949% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 54.9020% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 62.2222% (minimum 75%, Missing); hippocampal formation: 70.0000% (minimum 75%, Missing); hypothalamus: 71.7949% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 54.9020% (minimum 75%, Missing); lung: 59.5745% (minimum 75%, Missing); lymph node: 54.9020% (minimum 70%, Missing); midbrain: 68.2927% (minimum 75%, Missing); pancreas: 53.8462% (minimum 75%, Missing); parathyroid gland: 48.2759% (minimum 70%, Missing); pituitary gland: 71.7949% (minimum 75%, Missing); rectum: 52.8302% (minimum 70%, Missing); retina: 41.1765% (minimum 75%, Missing); salivary gland: 51.8519% (minimum 70%, Missing); skeletal muscle: 52.8302% (minimum 75%, Missing); skin: 54.9020% (minimum 65%, Missing); small intestine: 59.5745% (minimum 75%, Missing); smooth muscle: 56.0000% (minimum 75%, Missing); spinal cord: 63.6364% (minimum 75%, Missing); spleen: 49.1228% (minimum 65%, Missing); stomach: 54.9020% (minimum 70%, Missing); thyroid gland: 49.1228% (minimum 65%, Missing); tongue: 57.1429% (minimum 70%, Missing); urinary bladder: 63.6364% (minimum 70%, Missing)",-0.158772,-0.217241,-0.338235,0,4,partial,4,3,2.9,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177873,ZNF619,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.6364% (minimum 75%, Baseline (adaptation disabled)); amygdala: 70.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 68.2927% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 48.2759% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.1163% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.8696% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 71.7949% (minimum 75%, Baseline (adaptation disabled)); colon: 58.3333% (minimum 70%, Baseline (adaptation disabled)); duodenum: 54.9020% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 62.2222% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 71.7949% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 75%, Baseline (adaptation disabled)); liver: 54.9020% (minimum 75%, Baseline (adaptation disabled)); lung: 59.5745% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.9020% (minimum 70%, Baseline (adaptation disabled)); midbrain: 68.2927% (minimum 75%, Baseline (adaptation disabled)); pancreas: 53.8462% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 48.2759% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.7949% (minimum 75%, Baseline (adaptation disabled)); rectum: 52.8302% (minimum 70%, Baseline (adaptation disabled)); retina: 41.1765% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.8519% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 52.8302% (minimum 75%, Baseline (adaptation disabled)); skin: 54.9020% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.5745% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.6364% (minimum 75%, Baseline (adaptation disabled)); spleen: 49.1228% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.9020% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 49.1228% (minimum 65%, Baseline (adaptation disabled)); tongue: 57.1429% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.6364% (minimum 70%, Baseline (adaptation disabled))",-0.158772,-0.217241,-0.338235,0,4,partial,4,3,2.9,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177873,ZNF619,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,unresolved,incomplete_routine_rna,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177910,SPATA31C2,admission_only,True,False,False,False,10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Loriot 2025 · strict;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177910,SPATA31C2,selectivity_revised,True,False,False,False,10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Loriot 2025 · strict;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177910,SPATA31C2,grid_revised,True,False,False,False,10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Loriot 2025 · strict;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177910,SPATA31C2,current_adaptive,True,False,False,False,10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Loriot 2025 · strict;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177910,SPATA31C2,current_fixed,True,False,False,False,10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,1.2,1.2,2.1,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177938,CAPZA3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,1.2,1.2,2.1,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177938,CAPZA3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,1.2,1.2,2.1,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177938,CAPZA3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,1.2,1.2,2.1,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177938,CAPZA3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338307,0.293285,0.243285,0,1,partial,1.2,1.2,2.1,"liver: 1.2 nTPM (vital, limit 1)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177938,CAPZA3,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 95.7895% (minimum 99%, Missing)",0.05,0.03,-0.0321053,0,3,partial,0.4,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177947,CIMAP1A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.207895,0,3,partial,0.4,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177947,CIMAP1A,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.207895,0,3,partial,0.4,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177947,CIMAP1A,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.207895,0,3,partial,0.4,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177947,CIMAP1A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.207895,0,3,partial,0.4,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177947,CIMAP1A,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177992,SPATA31E1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177992,SPATA31E1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177992,SPATA31E1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177992,SPATA31E1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177992,SPATA31E1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9940% (minimum 99%, Missing); amygdala: 97.6190% (minimum 99%, Missing); basal ganglia: 97.2332% (minimum 99%, Missing); cerebral cortex: 98.2036% (minimum 99%, Missing); choroid plexus: 92.8302% (minimum 99%, Missing); hippocampal formation: 97.8131% (minimum 99%, Missing); hypothalamus: 97.2332% (minimum 99%, Missing); kidney: 98.7952% (minimum 99%, Missing); lung: 98.0080% (minimum 99%, Missing); midbrain: 98.2036% (minimum 99%, Missing); pancreas: 98.7952% (minimum 99%, Missing); pituitary gland: 97.4257% (minimum 99%, Missing); retina: 97.8131% (minimum 99%, Missing); spinal cord: 98.7952% (minimum 99%, Missing)",0.0281312,0.014,-0.0616981,0,80,unavailable,3.8,0.8,1.1,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177994,CIMIP6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328131,0.284,0.178302,0,80,unavailable,3.8,0.8,1.1,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177994,CIMIP6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328131,0.284,0.178302,0,80,unavailable,3.8,0.8,1.1,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177994,CIMIP6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328131,0.284,0.178302,0,80,unavailable,3.8,0.8,1.1,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177994,CIMIP6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328131,0.284,0.178302,0,80,unavailable,3.8,0.8,1.1,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000177994,CIMIP6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.00521531,0,1,partial,0.1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178021,TSPYL6,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245215,0,1,partial,0.1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178021,TSPYL6,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245215,0,1,partial,0.1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178021,TSPYL6,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245215,0,1,partial,0.1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178021,TSPYL6,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245215,0,1,partial,0.1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178021,TSPYL6,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.5079% (minimum 99%, Missing); basal ganglia: 92.7983% (minimum 99%, Missing); cerebellum: 98.1031% (minimum 99%, Missing); choroid plexus: 80.4161% (minimum 99%, Missing); heart muscle: 74.0232% (minimum 95%, Enhanced); hippocampal formation: 95.2938% (minimum 99%, Missing); hypothalamus: 94.9863% (minimum 99%, Missing); kidney: 94.9392% (minimum 95%, Enhanced); midbrain: 95.8427% (minimum 99%, Missing); pituitary gland: 95.6033% (minimum 99%, Missing); retina: 89.3950% (minimum 99%, Missing); skeletal muscle: 68.5106% (minimum 99%, Missing); spinal cord: 96.1558% (minimum 99%, Missing); tongue: 78.7773% (minimum 97%, Missing)",0.044026,-0.182227,-0.304894,0,7,partial,175.9,103.1,16,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 6); tongue: 103.1 nTPM (protected, limit 2); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 6); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 12); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 6); midbrain: 16.6 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); spinal cord: 15.3 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 6); urinary bladder: 13.6 nTPM (protected, limit 12); colon: 9.6 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 6); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 6)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178053,MLF1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skeletal muscle: 68.5106% (minimum 75%, Missing)",0.344026,0.0877727,-0.0648944,0,7,partial,175.9,103.1,16,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 6); tongue: 103.1 nTPM (protected, limit 2); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 6); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 12); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 6); midbrain: 16.6 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); spinal cord: 15.3 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 6); urinary bladder: 13.6 nTPM (protected, limit 12); colon: 9.6 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 6); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 6)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178053,MLF1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skeletal muscle: 68.5106% (minimum 75%, Missing)",0.344026,0.0877727,-0.0648944,0,7,partial,175.9,103.1,16,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 6); tongue: 103.1 nTPM (protected, limit 3); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 6); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 12); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 6); midbrain: 16.6 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); spinal cord: 15.3 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 6); urinary bladder: 13.6 nTPM (protected, limit 12); colon: 9.6 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 6); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 6)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178053,MLF1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skeletal muscle: 68.5106% (minimum 75%, Missing)",0.344026,0.0877727,-0.0648944,0,7,partial,175.9,103.1,16,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 6); tongue: 103.1 nTPM (protected, limit 3); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 6); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 12); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 6); midbrain: 16.6 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); spinal cord: 15.3 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 6); urinary bladder: 13.6 nTPM (protected, limit 12); colon: 9.6 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 6); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 6)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178053,MLF1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"heart muscle: 74.0232% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 68.5106% (minimum 75%, Baseline (adaptation disabled))",0.30987,0.0877727,-0.0648944,0,7,partial,175.9,103.1,16,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 1); tongue: 103.1 nTPM (protected, limit 3); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 1); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 3); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.6 nTPM (vital, limit 1); thyroid gland: 16 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); spinal cord: 15.3 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); urinary bladder: 13.6 nTPM (protected, limit 3); adipose tissue: 10.5 nTPM (manageable, limit 5); esophagus: 9.8 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); skin: 6 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 3); salivary gland: 4.9 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178053,MLF1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0408759,0.0245055,0.00268739,0,80,unavailable,1.2,0.9,1.5,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178093,TSSK6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340876,0.294505,0.242687,0,80,unavailable,1.2,0.9,1.5,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178093,TSSK6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340876,0.294505,0.242687,0,80,unavailable,1.2,0.9,1.5,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178093,TSSK6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340876,0.294505,0.242687,0,80,unavailable,1.2,0.9,1.5,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178093,TSSK6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340876,0.294505,0.242687,0,80,unavailable,1.2,0.9,1.5,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178093,TSSK6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8889% (minimum 99%, Missing); amygdala: 97.8022% (minimum 99%, Missing); basal ganglia: 96.7391% (minimum 99%, Missing); cerebral cortex: 97.8022% (minimum 99%, Missing); choroid plexus: 89.0000% (minimum 99%, Missing); hippocampal formation: 96.7391% (minimum 99%, Missing); hypothalamus: 95.6989% (minimum 99%, Missing); kidney: 97.8022% (minimum 99%, Missing); lung: 95.6989% (minimum 99%, Missing); midbrain: 98.8889% (minimum 99%, Missing); parathyroid gland: 96.7391% (minimum 97%, Missing); pituitary gland: 97.8022% (minimum 99%, Missing); retina: 93.6842% (minimum 99%, Missing); spinal cord: 98.8889% (minimum 99%, Missing)",0.0173913,-0.0026087,-0.1,0,80,unavailable,1.1,0.3,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178125,PPP1R42,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317391,0.267391,0.14,0,80,unavailable,1.1,0.3,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178125,PPP1R42,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317391,0.267391,0.14,0,80,unavailable,1.1,0.3,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178125,PPP1R42,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317391,0.267391,0.14,0,80,unavailable,1.1,0.3,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178125,PPP1R42,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317391,0.267391,0.14,0,80,unavailable,1.1,0.3,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178125,PPP1R42,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.5122% (minimum 95%, Missing); adrenal gland: 61.2903% (minimum 99%, Missing); amygdala: 71.2500% (minimum 99%, Missing); basal ganglia: 77.0270% (minimum 99%, Missing); bone marrow: 61.2903% (minimum 99%, Missing); cerebellum: 62.6374% (minimum 99%, Missing); cerebral cortex: 68.6747% (minimum 99%, Missing); choroid plexus: 83.8235% (minimum 99%, Missing); colon: 64.7727% (minimum 97%, Missing); duodenum: 50.4425% (minimum 99%, Missing); esophagus: 70.3704% (minimum 97%, Missing); heart muscle: 78.0822% (minimum 99%, Missing); hippocampal formation: 70.3704% (minimum 99%, Missing); hypothalamus: 65.5172% (minimum 99%, Missing); kidney: 59.3750% (minimum 99%, Missing); liver: 63.3333% (minimum 99%, Missing); lung: 67.8571% (minimum 99%, Missing); lymph node: 61.9565% (minimum 97%, Uncertain); midbrain: 69.5122% (minimum 99%, Missing); pancreas: 64.0449% (minimum 99%, Missing); parathyroid gland: 56.4356% (minimum 97%, Uncertain); pituitary gland: 78.0822% (minimum 99%, Missing); rectum: 61.9565% (minimum 97%, Missing); retina: 47.1074% (minimum 99%, Missing); salivary gland: 72.1519% (minimum 97%, Missing); skeletal muscle: 67.8571% (minimum 99%, Missing); skin: 54.8077% (minimum 95%, Missing); small intestine: 45.6000% (minimum 99%, Missing); smooth muscle: 68.6747% (minimum 99%, Missing); spinal cord: 64.7727% (minimum 99%, Missing); spleen: 63.3333% (minimum 95%, Uncertain); stomach: 56.4356% (minimum 97%, Missing); thymus: 60.0000% (minimum 95%, Missing); thyroid gland: 61.2903% (minimum 95%, Missing); tongue: 67.0588% (minimum 97%, Missing); urinary bladder: 67.8571% (minimum 97%, Missing)",-0.401923,-0.405644,-0.534,0,1,partial,6.8,4.4,4.7,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); parathyroid gland: 4.4 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); hypothalamus: 3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); skeletal muscle: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); amygdala: 2.3 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178177,LCORL,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 61.2903% (minimum 75%, Missing); amygdala: 71.2500% (minimum 75%, Missing); bone marrow: 61.2903% (minimum 75%, Missing); cerebellum: 62.6374% (minimum 75%, Missing); cerebral cortex: 68.6747% (minimum 75%, Missing); colon: 64.7727% (minimum 70%, Missing); duodenum: 50.4425% (minimum 75%, Missing); hippocampal formation: 70.3704% (minimum 75%, Missing); hypothalamus: 65.5172% (minimum 75%, Missing); kidney: 59.3750% (minimum 75%, Missing); liver: 63.3333% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); lymph node: 61.9565% (minimum 70%, Uncertain); midbrain: 69.5122% (minimum 75%, Missing); pancreas: 64.0449% (minimum 75%, Missing); parathyroid gland: 56.4356% (minimum 70%, Uncertain); rectum: 61.9565% (minimum 70%, Missing); retina: 47.1074% (minimum 75%, Missing); skeletal muscle: 67.8571% (minimum 75%, Missing); skin: 54.8077% (minimum 65%, Missing); small intestine: 45.6000% (minimum 75%, Missing); smooth muscle: 68.6747% (minimum 75%, Missing); spinal cord: 64.7727% (minimum 75%, Missing); spleen: 63.3333% (minimum 65%, Uncertain); stomach: 56.4356% (minimum 70%, Missing); thymus: 60.0000% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 67.0588% (minimum 70%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.101923,-0.135644,-0.294,0,1,partial,6.8,4.4,4.7,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); parathyroid gland: 4.4 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); hypothalamus: 3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); skeletal muscle: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); amygdala: 2.3 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178177,LCORL,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 61.2903% (minimum 75%, Missing); amygdala: 71.2500% (minimum 75%, Missing); bone marrow: 61.2903% (minimum 75%, Missing); cerebellum: 62.6374% (minimum 75%, Missing); cerebral cortex: 68.6747% (minimum 75%, Missing); colon: 64.7727% (minimum 70%, Missing); duodenum: 50.4425% (minimum 75%, Missing); hippocampal formation: 70.3704% (minimum 75%, Missing); hypothalamus: 65.5172% (minimum 75%, Missing); kidney: 59.3750% (minimum 75%, Missing); liver: 63.3333% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); lymph node: 61.9565% (minimum 70%, Uncertain); midbrain: 69.5122% (minimum 75%, Missing); pancreas: 64.0449% (minimum 75%, Missing); parathyroid gland: 56.4356% (minimum 70%, Uncertain); rectum: 61.9565% (minimum 70%, Missing); retina: 47.1074% (minimum 75%, Missing); skeletal muscle: 67.8571% (minimum 75%, Missing); skin: 54.8077% (minimum 65%, Missing); small intestine: 45.6000% (minimum 75%, Missing); smooth muscle: 68.6747% (minimum 75%, Missing); spinal cord: 64.7727% (minimum 75%, Missing); spleen: 63.3333% (minimum 65%, Uncertain); stomach: 56.4356% (minimum 70%, Missing); thymus: 60.0000% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 67.0588% (minimum 70%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.101923,-0.135644,-0.294,0,1,partial,6.8,4.4,4.7,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); parathyroid gland: 4.4 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); hypothalamus: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178177,LCORL,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 61.2903% (minimum 75%, Missing); amygdala: 71.2500% (minimum 75%, Missing); bone marrow: 61.2903% (minimum 75%, Missing); cerebellum: 62.6374% (minimum 75%, Missing); cerebral cortex: 68.6747% (minimum 75%, Missing); colon: 64.7727% (minimum 70%, Missing); duodenum: 50.4425% (minimum 75%, Missing); hippocampal formation: 70.3704% (minimum 75%, Missing); hypothalamus: 65.5172% (minimum 75%, Missing); kidney: 59.3750% (minimum 75%, Missing); liver: 63.3333% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); lymph node: 61.9565% (minimum 70%, Uncertain); midbrain: 69.5122% (minimum 75%, Missing); pancreas: 64.0449% (minimum 75%, Missing); parathyroid gland: 56.4356% (minimum 70%, Uncertain); rectum: 61.9565% (minimum 70%, Missing); retina: 47.1074% (minimum 75%, Missing); skeletal muscle: 67.8571% (minimum 75%, Missing); skin: 54.8077% (minimum 65%, Missing); small intestine: 45.6000% (minimum 75%, Missing); smooth muscle: 68.6747% (minimum 75%, Missing); spinal cord: 64.7727% (minimum 75%, Missing); spleen: 63.3333% (minimum 65%, Uncertain); stomach: 56.4356% (minimum 70%, Missing); thymus: 60.0000% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 67.0588% (minimum 70%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.101923,-0.135644,-0.294,0,1,partial,6.8,4.4,4.7,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); parathyroid gland: 4.4 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); hypothalamus: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178177,LCORL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 61.2903% (minimum 75%, Baseline (adaptation disabled)); amygdala: 71.2500% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.2903% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.6374% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.6747% (minimum 75%, Baseline (adaptation disabled)); colon: 64.7727% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.4425% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.3704% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.5172% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.3750% (minimum 75%, Baseline (adaptation disabled)); liver: 63.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 67.8571% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.9565% (minimum 70%, Baseline (adaptation disabled)); midbrain: 69.5122% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.0449% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 56.4356% (minimum 70%, Baseline (adaptation disabled)); rectum: 61.9565% (minimum 70%, Baseline (adaptation disabled)); retina: 47.1074% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 67.8571% (minimum 75%, Baseline (adaptation disabled)); skin: 54.8077% (minimum 65%, Baseline (adaptation disabled)); small intestine: 45.6000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.6747% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.7727% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.3333% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.4356% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 61.2903% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.0588% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.8571% (minimum 70%, Baseline (adaptation disabled))",-0.101923,-0.135644,-0.294,0,1,partial,6.8,4.4,4.7,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); parathyroid gland: 4.4 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); hypothalamus: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178177,LCORL,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Missing); adrenal gland: 73.0769% (minimum 99%, Missing); amygdala: 80.8511% (minimum 99%, Missing); basal ganglia: 77.5510% (minimum 99%, Missing); bone marrow: 67.8571% (minimum 99%, Missing); cerebellum: 70.3704% (minimum 99%, Missing); cerebral cortex: 71.6981% (minimum 99%, Missing); choroid plexus: 84.4444% (minimum 99%, Missing); colon: 74.5098% (minimum 97%, Missing); duodenum: 86.3636% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 73.0769% (minimum 99%, Missing); hippocampal formation: 80.8511% (minimum 99%, Missing); hypothalamus: 82.6087% (minimum 99%, Missing); kidney: 71.6981% (minimum 99%, Missing); liver: 77.5510% (minimum 99%, Missing); lung: 70.3704% (minimum 99%, Missing); lymph node: 62.2951% (minimum 97%, Missing); midbrain: 82.6087% (minimum 99%, Missing); pancreas: 67.8571% (minimum 99%, Missing); parathyroid gland: 56.7164% (minimum 97%, Missing); pituitary gland: 69.0909% (minimum 99%, Missing); rectum: 79.1667% (minimum 97%, Missing); retina: 59.3750% (minimum 99%, Missing); salivary gland: 70.3704% (minimum 97%, Missing); skeletal muscle: 69.0909% (minimum 99%, Missing); skin: 62.2951% (minimum 95%, Missing); small intestine: 77.5510% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 80.8511% (minimum 99%, Missing); spleen: 60.3175% (minimum 95%, Missing); stomach: 70.3704% (minimum 97%, Missing); thymus: 55.0725% (minimum 95%, Missing); thyroid gland: 60.3175% (minimum 95%, Missing); tongue: 67.8571% (minimum 97%, Missing); urinary bladder: 71.6981% (minimum 97%, Missing)",-0.399275,-0.402836,-0.39625,0,80,unavailable,2.6,2.9,3.1,"parathyroid gland: 2.9 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178229,ZNF543,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.0769% (minimum 75%, Missing); bone marrow: 67.8571% (minimum 75%, Missing); cerebellum: 70.3704% (minimum 75%, Missing); cerebral cortex: 71.6981% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 73.0769% (minimum 75%, Missing); kidney: 71.6981% (minimum 75%, Missing); lung: 70.3704% (minimum 75%, Missing); lymph node: 62.2951% (minimum 70%, Missing); pancreas: 67.8571% (minimum 75%, Missing); parathyroid gland: 56.7164% (minimum 70%, Missing); pituitary gland: 69.0909% (minimum 75%, Missing); retina: 59.3750% (minimum 75%, Missing); skeletal muscle: 69.0909% (minimum 75%, Missing); skin: 62.2951% (minimum 65%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 60.3175% (minimum 65%, Missing); thymus: 55.0725% (minimum 65%, Missing); thyroid gland: 60.3175% (minimum 65%, Missing); tongue: 67.8571% (minimum 70%, Missing)",-0.0992754,-0.132836,-0.15625,0,80,unavailable,2.6,2.9,3.1,"parathyroid gland: 2.9 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178229,ZNF543,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.0769% (minimum 75%, Missing); bone marrow: 67.8571% (minimum 75%, Missing); cerebellum: 70.3704% (minimum 75%, Missing); cerebral cortex: 71.6981% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 73.0769% (minimum 75%, Missing); kidney: 71.6981% (minimum 75%, Missing); lung: 70.3704% (minimum 75%, Missing); lymph node: 62.2951% (minimum 70%, Missing); pancreas: 67.8571% (minimum 75%, Missing); parathyroid gland: 56.7164% (minimum 70%, Missing); pituitary gland: 69.0909% (minimum 75%, Missing); retina: 59.3750% (minimum 75%, Missing); skeletal muscle: 69.0909% (minimum 75%, Missing); skin: 62.2951% (minimum 65%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 60.3175% (minimum 65%, Missing); thymus: 55.0725% (minimum 65%, Missing); thyroid gland: 60.3175% (minimum 65%, Missing); tongue: 67.8571% (minimum 70%, Missing)",-0.0992754,-0.132836,-0.15625,0,80,unavailable,2.6,2.9,3.1,"retina: 2.6 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178229,ZNF543,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.0769% (minimum 75%, Missing); bone marrow: 67.8571% (minimum 75%, Missing); cerebellum: 70.3704% (minimum 75%, Missing); cerebral cortex: 71.6981% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 73.0769% (minimum 75%, Missing); kidney: 71.6981% (minimum 75%, Missing); lung: 70.3704% (minimum 75%, Missing); lymph node: 62.2951% (minimum 70%, Missing); pancreas: 67.8571% (minimum 75%, Missing); parathyroid gland: 56.7164% (minimum 70%, Missing); pituitary gland: 69.0909% (minimum 75%, Missing); retina: 59.3750% (minimum 75%, Missing); skeletal muscle: 69.0909% (minimum 75%, Missing); skin: 62.2951% (minimum 65%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 60.3175% (minimum 65%, Missing); thymus: 55.0725% (minimum 65%, Missing); thyroid gland: 60.3175% (minimum 65%, Missing); tongue: 67.8571% (minimum 70%, Missing)",-0.0992754,-0.132836,-0.15625,0,80,unavailable,2.6,2.9,3.1,"retina: 2.6 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178229,ZNF543,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.0769% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 67.8571% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.3704% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 71.6981% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 73.0769% (minimum 75%, Baseline (adaptation disabled)); kidney: 71.6981% (minimum 75%, Baseline (adaptation disabled)); lung: 70.3704% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.2951% (minimum 70%, Baseline (adaptation disabled)); pancreas: 67.8571% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 56.7164% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.0909% (minimum 75%, Baseline (adaptation disabled)); retina: 59.3750% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 69.0909% (minimum 75%, Baseline (adaptation disabled)); skin: 62.2951% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.3175% (minimum 65%, Baseline (adaptation disabled)); thymus: 55.0725% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 60.3175% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.8571% (minimum 70%, Baseline (adaptation disabled))",-0.0992754,-0.132836,-0.15625,0,80,unavailable,2.6,2.9,3.1,"retina: 2.6 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178229,ZNF543,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.0787% (minimum 99%, Missing); retina: 98.5177% (minimum 99%, Missing)",0.0431034,0.0265398,-0.0192135,0,80,unavailable,2.6,0.3,0.6,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178257,PRM3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343103,0.29654,0.220787,0,80,unavailable,2.6,0.3,0.6,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178257,PRM3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343103,0.29654,0.220787,0,80,unavailable,2.6,0.3,0.6,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178257,PRM3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343103,0.29654,0.220787,0,80,unavailable,2.6,0.3,0.6,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178257,PRM3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343103,0.29654,0.220787,0,80,unavailable,2.6,0.3,0.6,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178257,PRM3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178279,TNP2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178279,TNP2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178279,TNP2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178279,TNP2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178279,TNP2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178287,SPAG11A,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178287,SPAG11A,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178287,SPAG11A,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178287,SPAG11A,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299978,0.25,0,3,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178287,SPAG11A,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 84.1121% (minimum 99%, Missing); amygdala: 90.0000% (minimum 99%, Missing); basal ganglia: 87.3786% (minimum 99%, Missing); bone marrow: 37.5000% (minimum 99%, Missing); cerebellum: 89.1089% (minimum 99%, Missing); cerebral cortex: 87.3786% (minimum 99%, Missing); choroid plexus: 68.1818% (minimum 99%, Missing); colon: 64.2857% (minimum 97%, Missing); duodenum: 74.3802% (minimum 99%, Missing); esophagus: 62.5000% (minimum 97%, Missing); heart muscle: 80.3571% (minimum 99%, Missing); hippocampal formation: 88.2353% (minimum 99%, Missing); hypothalamus: 87.3786% (minimum 99%, Missing); kidney: 84.1121% (minimum 99%, Missing); liver: 51.7241% (minimum 99%, Missing); lung: 82.5688% (minimum 99%, Missing); lymph node: 46.1538% (minimum 97%, Missing); midbrain: 88.2353% (minimum 99%, Missing); pancreas: 80.3571% (minimum 99%, Missing); parathyroid gland: 90.0000% (minimum 97%, Missing); pituitary gland: 75.6303% (minimum 99%, Missing); rectum: 57.3248% (minimum 97%, Missing); retina: 78.9474% (minimum 99%, Missing); salivary gland: 62.5000% (minimum 80%, Enhanced); skeletal muscle: 84.1121% (minimum 99%, Missing); skin: 55.2147% (minimum 95%, Missing); small intestine: 67.1642% (minimum 99%, Missing); smooth muscle: 87.3786% (minimum 99%, Missing); spinal cord: 90.0000% (minimum 99%, Missing); spleen: 64.2857% (minimum 95%, Missing); stomach: 75.6303% (minimum 97%, Missing); thymus: 62.9371% (minimum 95%, Missing); thyroid gland: 83.3333% (minimum 95%, Missing); tongue: 86.5385% (minimum 97%, Missing); urinary bladder: 85.7143% (minimum 97%, Missing)",-0.397853,-0.508462,-0.615,0,3,partial,15,10.5,7.3,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 2); liver: 8.4 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); rectum: 6.7 nTPM (protected, limit 2); esophagus: 5.4 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); colon: 5 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178295,GEN1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.5000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 74.3802% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); liver: 51.7241% (minimum 75%, Missing); lymph node: 46.1538% (minimum 70%, Missing); rectum: 57.3248% (minimum 70%, Missing); skin: 55.2147% (minimum 65%, Missing); small intestine: 67.1642% (minimum 75%, Missing); spleen: 64.2857% (minimum 65%, Missing); thymus: 62.9371% (minimum 65%, Missing)",-0.0978528,-0.238462,-0.375,0,3,partial,15,10.5,7.3,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 2); liver: 8.4 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); rectum: 6.7 nTPM (protected, limit 2); esophagus: 5.4 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); colon: 5 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178295,GEN1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.5000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 74.3802% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); liver: 51.7241% (minimum 75%, Missing); lymph node: 46.1538% (minimum 70%, Missing); rectum: 57.3248% (minimum 70%, Missing); skin: 55.2147% (minimum 65%, Missing); small intestine: 67.1642% (minimum 75%, Missing); spleen: 64.2857% (minimum 65%, Missing); thymus: 62.9371% (minimum 65%, Missing)",-0.0978528,-0.238462,-0.375,0,3,partial,15,10.5,7.3,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 3); liver: 8.4 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); rectum: 6.7 nTPM (protected, limit 3); esophagus: 5.4 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); colon: 5 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178295,GEN1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.5000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 74.3802% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); liver: 51.7241% (minimum 75%, Missing); lymph node: 46.1538% (minimum 70%, Missing); rectum: 57.3248% (minimum 70%, Missing); skin: 55.2147% (minimum 65%, Missing); small intestine: 67.1642% (minimum 75%, Missing); spleen: 64.2857% (minimum 65%, Missing); thymus: 62.9371% (minimum 65%, Missing)",-0.0978528,-0.238462,-0.375,0,3,partial,15,10.5,7.3,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 3); liver: 8.4 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); rectum: 6.7 nTPM (protected, limit 3); esophagus: 5.4 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); colon: 5 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178295,GEN1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.5000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.1818% (minimum 75%, Baseline (adaptation disabled)); colon: 64.2857% (minimum 70%, Baseline (adaptation disabled)); duodenum: 74.3802% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.5000% (minimum 70%, Baseline (adaptation disabled)); liver: 51.7241% (minimum 75%, Baseline (adaptation disabled)); lymph node: 46.1538% (minimum 70%, Baseline (adaptation disabled)); rectum: 57.3248% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 70%, Baseline (adaptation disabled)); skin: 55.2147% (minimum 65%, Baseline (adaptation disabled)); small intestine: 67.1642% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.2857% (minimum 65%, Baseline (adaptation disabled)); thymus: 62.9371% (minimum 65%, Baseline (adaptation disabled))",-0.0978528,-0.238462,-0.375,0,3,partial,15,10.5,7.3,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 3); liver: 8.4 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); rectum: 6.7 nTPM (protected, limit 3); esophagus: 5.4 nTPM (protected, limit 3); salivary gland: 5.4 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); colon: 5 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178295,GEN1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 83.7209% (minimum 99%, Missing); amygdala: 87.8049% (minimum 99%, Missing); basal ganglia: 97.2973% (minimum 99%, Missing); bone marrow: 81.8182% (minimum 99%, Missing); cerebellum: 97.2973% (minimum 99%, Missing); cerebral cortex: 97.2973% (minimum 99%, Missing); colon: 92.3077% (minimum 97%, Missing); duodenum: 97.2973% (minimum 99%, Missing); hippocampal formation: 97.2973% (minimum 99%, Missing); hypothalamus: 97.2973% (minimum 99%, Missing); liver: 47.3684% (minimum 99%, Missing); pancreas: 83.7209% (minimum 99%, Missing); pituitary gland: 97.2973% (minimum 99%, Missing); retina: 97.2973% (minimum 99%, Missing); salivary gland: 94.7368% (minimum 97%, Missing); skeletal muscle: 87.8049% (minimum 99%, Missing); skin: 87.8049% (minimum 95%, Missing); small intestine: 97.2973% (minimum 99%, Missing); spleen: 61.0169% (minimum 95%, Missing); thymus: 94.7368% (minimum 95%, Missing)",-0.339831,-0.0469231,-0.516316,0,80,unavailable,4,0.3,2.3,"liver: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178297,TMPRSS9,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 47.3684% (minimum 75%, Missing); spleen: 61.0169% (minimum 65%, Missing)",-0.0398305,0.223077,-0.276316,0,80,unavailable,4,0.3,2.3,"liver: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178297,TMPRSS9,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 47.3684% (minimum 75%, Missing); spleen: 61.0169% (minimum 65%, Missing)",-0.0398305,0.223077,-0.276316,0,80,unavailable,4,0.3,2.3,"liver: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178297,TMPRSS9,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 47.3684% (minimum 75%, Missing); spleen: 61.0169% (minimum 65%, Missing)",-0.0398305,0.223077,-0.276316,0,80,unavailable,4,0.3,2.3,"liver: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178297,TMPRSS9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 47.3684% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.0169% (minimum 65%, Baseline (adaptation disabled))",-0.0398305,0.223077,-0.276316,0,80,unavailable,4,0.3,2.3,"liver: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178297,TMPRSS9,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.7241% (minimum 95%, Missing); adrenal gland: 42.8571% (minimum 99%, Missing); amygdala: 54.5455% (minimum 99%, Missing); basal ganglia: 49.1803% (minimum 99%, Missing); bone marrow: 41.6667% (minimum 99%, Missing); cerebellum: 38.9610% (minimum 99%, Missing); cerebral cortex: 36.5854% (minimum 99%, Missing); choroid plexus: 81.0811% (minimum 99%, Missing); colon: 50.0000% (minimum 97%, Missing); duodenum: 76.9231% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 51.7241% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 43.4783% (minimum 99%, Missing); kidney: 62.5000% (minimum 99%, Missing); liver: 49.1803% (minimum 99%, Missing); lung: 50.8475% (minimum 99%, Missing); lymph node: 68.1818% (minimum 97%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 57.6923% (minimum 99%, Missing); parathyroid gland: 43.4783% (minimum 97%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); rectum: 68.1818% (minimum 97%, Missing); retina: 27.0270% (minimum 99%, Missing); salivary gland: 58.8235% (minimum 97%, Missing); skeletal muscle: 56.6038% (minimum 99%, Missing); skin: 54.5455% (minimum 95%, Missing); small intestine: 62.5000% (minimum 99%, Missing); smooth muscle: 62.5000% (minimum 99%, Missing); spinal cord: 44.7761% (minimum 99%, Missing); spleen: 62.5000% (minimum 95%, Missing); stomach: 57.6923% (minimum 97%, Missing); thymus: 58.8235% (minimum 95%, Missing); thyroid gland: 46.1538% (minimum 95%, Missing); tongue: 66.6667% (minimum 97%, Missing); urinary bladder: 61.2245% (minimum 97%, Missing)",-0.488462,-0.535217,-0.71973,0,1,partial,8.1,3.9,3.5,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178385,PLEKHM3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.7241% (minimum 65%, Missing); adrenal gland: 42.8571% (minimum 75%, Missing); amygdala: 54.5455% (minimum 75%, Missing); basal ganglia: 49.1803% (minimum 75%, Missing); bone marrow: 41.6667% (minimum 75%, Missing); cerebellum: 38.9610% (minimum 75%, Missing); cerebral cortex: 36.5854% (minimum 75%, Missing); colon: 50.0000% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 43.4783% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 49.1803% (minimum 75%, Missing); lung: 50.8475% (minimum 75%, Missing); lymph node: 68.1818% (minimum 70%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 57.6923% (minimum 75%, Missing); parathyroid gland: 43.4783% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); rectum: 68.1818% (minimum 70%, Missing); retina: 27.0270% (minimum 75%, Missing); salivary gland: 58.8235% (minimum 70%, Missing); skeletal muscle: 56.6038% (minimum 75%, Missing); skin: 54.5455% (minimum 65%, Missing); small intestine: 62.5000% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spinal cord: 44.7761% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 57.6923% (minimum 70%, Missing); thymus: 58.8235% (minimum 65%, Missing); thyroid gland: 46.1538% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 61.2245% (minimum 70%, Missing)",-0.188462,-0.265217,-0.47973,0,1,partial,8.1,3.9,3.5,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178385,PLEKHM3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.7241% (minimum 65%, Missing); adrenal gland: 42.8571% (minimum 75%, Missing); amygdala: 54.5455% (minimum 75%, Missing); basal ganglia: 49.1803% (minimum 75%, Missing); bone marrow: 41.6667% (minimum 75%, Missing); cerebellum: 38.9610% (minimum 75%, Missing); cerebral cortex: 36.5854% (minimum 75%, Missing); colon: 50.0000% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 43.4783% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 49.1803% (minimum 75%, Missing); lung: 50.8475% (minimum 75%, Missing); lymph node: 68.1818% (minimum 70%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 57.6923% (minimum 75%, Missing); parathyroid gland: 43.4783% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); rectum: 68.1818% (minimum 70%, Missing); retina: 27.0270% (minimum 75%, Missing); salivary gland: 58.8235% (minimum 70%, Missing); skeletal muscle: 56.6038% (minimum 75%, Missing); skin: 54.5455% (minimum 65%, Missing); small intestine: 62.5000% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spinal cord: 44.7761% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 57.6923% (minimum 70%, Missing); thymus: 58.8235% (minimum 65%, Missing); thyroid gland: 46.1538% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 61.2245% (minimum 70%, Missing)",-0.188462,-0.265217,-0.47973,0,1,partial,8.1,3.9,3.5,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178385,PLEKHM3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.7241% (minimum 65%, Missing); adrenal gland: 42.8571% (minimum 75%, Missing); amygdala: 54.5455% (minimum 75%, Missing); basal ganglia: 49.1803% (minimum 75%, Missing); bone marrow: 41.6667% (minimum 75%, Missing); cerebellum: 38.9610% (minimum 75%, Missing); cerebral cortex: 36.5854% (minimum 75%, Missing); colon: 50.0000% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 43.4783% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 49.1803% (minimum 75%, Missing); lung: 50.8475% (minimum 75%, Missing); lymph node: 68.1818% (minimum 70%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 57.6923% (minimum 75%, Missing); parathyroid gland: 43.4783% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); rectum: 68.1818% (minimum 70%, Missing); retina: 27.0270% (minimum 75%, Missing); salivary gland: 58.8235% (minimum 70%, Missing); skeletal muscle: 56.6038% (minimum 75%, Missing); skin: 54.5455% (minimum 65%, Missing); small intestine: 62.5000% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spinal cord: 44.7761% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 57.6923% (minimum 70%, Missing); thymus: 58.8235% (minimum 65%, Missing); thyroid gland: 46.1538% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 61.2245% (minimum 70%, Missing)",-0.188462,-0.265217,-0.47973,0,1,partial,8.1,3.9,3.5,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178385,PLEKHM3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.7241% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 42.8571% (minimum 75%, Baseline (adaptation disabled)); amygdala: 54.5455% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 49.1803% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 41.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 38.9610% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 36.5854% (minimum 75%, Baseline (adaptation disabled)); colon: 50.0000% (minimum 70%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 51.7241% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 43.4783% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.5000% (minimum 75%, Baseline (adaptation disabled)); liver: 49.1803% (minimum 75%, Baseline (adaptation disabled)); lung: 50.8475% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.1818% (minimum 70%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 57.6923% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 43.4783% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 75%, Baseline (adaptation disabled)); rectum: 68.1818% (minimum 70%, Baseline (adaptation disabled)); retina: 27.0270% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.8235% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 56.6038% (minimum 75%, Baseline (adaptation disabled)); skin: 54.5455% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.5000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 44.7761% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.6923% (minimum 70%, Baseline (adaptation disabled)); thymus: 58.8235% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 46.1538% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.2245% (minimum 70%, Baseline (adaptation disabled))",-0.188462,-0.265217,-0.47973,0,1,partial,8.1,3.9,3.5,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178385,PLEKHM3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 67.0213% (minimum 95%, Missing); adrenal gland: 63.6364% (minimum 99%, Missing); amygdala: 70.0000% (minimum 99%, Missing); basal ganglia: 63.6364% (minimum 99%, Missing); bone marrow: 75.9036% (minimum 99%, Missing); cerebellum: 55.2632% (minimum 99%, Missing); cerebral cortex: 60.0000% (minimum 99%, Missing); choroid plexus: 74.1176% (minimum 99%, Missing); colon: 59.4340% (minimum 97%, Missing); duodenum: 61.7647% (minimum 99%, Missing); esophagus: 68.4783% (minimum 97%, Missing); heart muscle: 57.2727% (minimum 99%, Missing); hippocampal formation: 67.0213% (minimum 99%, Missing); hypothalamus: 63.6364% (minimum 99%, Missing); kidney: 62.3762% (minimum 99%, Missing); liver: 71.5909% (minimum 98%, Approved); lung: 62.3762% (minimum 98%, Approved); lymph node: 64.2857% (minimum 95%, Approved); midbrain: 70.0000% (minimum 99%, Missing); pancreas: 69.2308% (minimum 99%, Missing); parathyroid gland: 57.2727% (minimum 97%, Missing); pituitary gland: 61.1650% (minimum 99%, Missing); rectum: 53.3898% (minimum 97%, Missing); retina: 59.4340% (minimum 99%, Missing); salivary gland: 64.2857% (minimum 97%, Missing); skeletal muscle: 75.9036% (minimum 98%, Approved); skin: 56.7568% (minimum 90%, Approved); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 63.0000% (minimum 98%, Approved); spinal cord: 71.5909% (minimum 99%, Missing); spleen: 56.7568% (minimum 90%, Approved); stomach: 57.2727% (minimum 97%, Missing); thymus: 70.0000% (minimum 95%, Missing); thyroid gland: 50.4000% (minimum 95%, Missing); tongue: 80.7692% (minimum 97%, Missing); urinary bladder: 62.3762% (minimum 97%, Missing)",-0.446,-0.436102,-0.437368,0,8,partial,5.1,5.5,6.2,"thyroid gland: 6.2 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); cerebellum: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); stomach: 4.7 nTPM (protected, limit 2); heart muscle: 4.7 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 2); smooth muscle: 3.7 nTPM (vital, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 2); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178386,ZNF223,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 63.6364% (minimum 75%, Missing); cerebellum: 55.2632% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 74.1176% (minimum 75%, Missing); colon: 59.4340% (minimum 70%, Missing); duodenum: 61.7647% (minimum 75%, Missing); esophagus: 68.4783% (minimum 70%, Missing); heart muscle: 57.2727% (minimum 75%, Missing); hippocampal formation: 67.0213% (minimum 75%, Missing); hypothalamus: 63.6364% (minimum 75%, Missing); kidney: 62.3762% (minimum 75%, Missing); lung: 62.3762% (minimum 70%, Approved); lymph node: 64.2857% (minimum 65%, Approved); midbrain: 70.0000% (minimum 75%, Missing); pancreas: 69.2308% (minimum 75%, Missing); parathyroid gland: 57.2727% (minimum 70%, Missing); pituitary gland: 61.1650% (minimum 75%, Missing); rectum: 53.3898% (minimum 70%, Missing); retina: 59.4340% (minimum 75%, Missing); salivary gland: 64.2857% (minimum 70%, Missing); skin: 56.7568% (minimum 60%, Approved); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 63.0000% (minimum 70%, Approved); spinal cord: 71.5909% (minimum 75%, Missing); spleen: 56.7568% (minimum 60%, Approved); stomach: 57.2727% (minimum 70%, Missing); thyroid gland: 50.4000% (minimum 65%, Missing); urinary bladder: 62.3762% (minimum 70%, Missing)",-0.146,-0.166102,-0.197368,0,8,partial,5.1,5.5,6.2,"thyroid gland: 6.2 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); cerebellum: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); stomach: 4.7 nTPM (protected, limit 2); heart muscle: 4.7 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 2); smooth muscle: 3.7 nTPM (vital, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 2); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178386,ZNF223,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 63.6364% (minimum 75%, Missing); cerebellum: 55.2632% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 74.1176% (minimum 75%, Missing); colon: 59.4340% (minimum 70%, Missing); duodenum: 61.7647% (minimum 75%, Missing); esophagus: 68.4783% (minimum 70%, Missing); heart muscle: 57.2727% (minimum 75%, Missing); hippocampal formation: 67.0213% (minimum 75%, Missing); hypothalamus: 63.6364% (minimum 75%, Missing); kidney: 62.3762% (minimum 75%, Missing); lung: 62.3762% (minimum 70%, Approved); lymph node: 64.2857% (minimum 65%, Approved); midbrain: 70.0000% (minimum 75%, Missing); pancreas: 69.2308% (minimum 75%, Missing); parathyroid gland: 57.2727% (minimum 70%, Missing); pituitary gland: 61.1650% (minimum 75%, Missing); rectum: 53.3898% (minimum 70%, Missing); retina: 59.4340% (minimum 75%, Missing); salivary gland: 64.2857% (minimum 70%, Missing); skin: 56.7568% (minimum 60%, Approved); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 63.0000% (minimum 70%, Approved); spinal cord: 71.5909% (minimum 75%, Missing); spleen: 56.7568% (minimum 60%, Approved); stomach: 57.2727% (minimum 70%, Missing); thyroid gland: 50.4000% (minimum 65%, Missing); urinary bladder: 62.3762% (minimum 70%, Missing)",-0.146,-0.166102,-0.197368,0,8,partial,5.1,5.5,6.2,"thyroid gland: 6.2 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); cerebellum: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); stomach: 4.7 nTPM (protected, limit 3); heart muscle: 4.7 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 2); urinary bladder: 3.8 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178386,ZNF223,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 63.6364% (minimum 75%, Missing); cerebellum: 55.2632% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 74.1176% (minimum 75%, Missing); colon: 59.4340% (minimum 70%, Missing); duodenum: 61.7647% (minimum 75%, Missing); esophagus: 68.4783% (minimum 70%, Missing); heart muscle: 57.2727% (minimum 75%, Missing); hippocampal formation: 67.0213% (minimum 75%, Missing); hypothalamus: 63.6364% (minimum 75%, Missing); kidney: 62.3762% (minimum 75%, Missing); lung: 62.3762% (minimum 70%, Approved); lymph node: 64.2857% (minimum 65%, Approved); midbrain: 70.0000% (minimum 75%, Missing); pancreas: 69.2308% (minimum 75%, Missing); parathyroid gland: 57.2727% (minimum 70%, Missing); pituitary gland: 61.1650% (minimum 75%, Missing); rectum: 53.3898% (minimum 70%, Missing); retina: 59.4340% (minimum 75%, Missing); salivary gland: 64.2857% (minimum 70%, Missing); skin: 56.7568% (minimum 60%, Approved); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 63.0000% (minimum 70%, Approved); spinal cord: 71.5909% (minimum 75%, Missing); spleen: 56.7568% (minimum 60%, Approved); stomach: 57.2727% (minimum 70%, Missing); thyroid gland: 50.4000% (minimum 65%, Missing); urinary bladder: 62.3762% (minimum 70%, Missing)",-0.146,-0.166102,-0.197368,0,8,partial,5.1,5.5,6.2,"thyroid gland: 6.2 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); cerebellum: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); stomach: 4.7 nTPM (protected, limit 3); heart muscle: 4.7 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 2); urinary bladder: 3.8 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178386,ZNF223,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.6364% (minimum 75%, Baseline (adaptation disabled)); amygdala: 70.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 63.6364% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.2632% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.1176% (minimum 75%, Baseline (adaptation disabled)); colon: 59.4340% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.7647% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.4783% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 57.2727% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.0213% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.6364% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.3762% (minimum 75%, Baseline (adaptation disabled)); liver: 71.5909% (minimum 75%, Baseline (adaptation disabled)); lung: 62.3762% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.2857% (minimum 70%, Baseline (adaptation disabled)); midbrain: 70.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.2308% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.2727% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 61.1650% (minimum 75%, Baseline (adaptation disabled)); rectum: 53.3898% (minimum 70%, Baseline (adaptation disabled)); retina: 59.4340% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.2857% (minimum 70%, Baseline (adaptation disabled)); skin: 56.7568% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.5909% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.7568% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.2727% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 50.4000% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 62.3762% (minimum 70%, Baseline (adaptation disabled))",-0.146,-0.166102,-0.197368,0,8,partial,5.1,5.5,6.2,"thyroid gland: 6.2 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); cerebellum: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); stomach: 4.7 nTPM (protected, limit 3); heart muscle: 4.7 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); lymph node: 3.5 nTPM (protected, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178386,ZNF223,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178395,CCDC185,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178395,CCDC185,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178395,CCDC185,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178395,CCDC185,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178395,CCDC185,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 51.6129% (minimum 99%, Missing); basal ganglia: 43.2432% (minimum 99%, Missing); cerebellum: 45.7143% (minimum 99%, Missing); cerebral cortex: 76.1905% (minimum 99%, Missing); hippocampal formation: 44.4444% (minimum 99%, Missing); hypothalamus: 94.1176% (minimum 99%, Missing); retina: 76.1905% (minimum 99%, Missing); spinal cord: 94.1176% (minimum 99%, Missing)",0.05,0.03,-0.557568,0,80,unavailable,2.1,0,0,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178403,NEUROG2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 51.6129% (minimum 75%, Missing); basal ganglia: 43.2432% (minimum 75%, Missing); cerebellum: 45.7143% (minimum 75%, Missing); hippocampal formation: 44.4444% (minimum 75%, Missing)",0.35,0.3,-0.317568,0,80,unavailable,2.1,0,0,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178403,NEUROG2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 51.6129% (minimum 75%, Missing); basal ganglia: 43.2432% (minimum 75%, Missing); cerebellum: 45.7143% (minimum 75%, Missing); hippocampal formation: 44.4444% (minimum 75%, Missing)",0.35,0.3,-0.317568,0,80,unavailable,2.1,0,0,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178403,NEUROG2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 51.6129% (minimum 75%, Missing); basal ganglia: 43.2432% (minimum 75%, Missing); cerebellum: 45.7143% (minimum 75%, Missing); hippocampal formation: 44.4444% (minimum 75%, Missing)",0.35,0.3,-0.317568,0,80,unavailable,2.1,0,0,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178403,NEUROG2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 51.6129% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 43.2432% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 45.7143% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 44.4444% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.317568,0,80,unavailable,2.1,0,0,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178403,NEUROG2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.2432% (minimum 99%, Missing); duodenum: 97.5265% (minimum 99%, Missing)",0.0357143,0.00526502,-0.0575676,0,80,unavailable,2,0.7,0.4,"bone marrow: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178404,CEP295NL,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335714,0.275265,0.182432,0,80,unavailable,2,0.7,0.4,"bone marrow: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178404,CEP295NL,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335714,0.275265,0.182432,0,80,unavailable,2,0.7,0.4,"bone marrow: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178404,CEP295NL,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335714,0.275265,0.182432,0,80,unavailable,2,0.7,0.4,"bone marrow: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178404,CEP295NL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335714,0.275265,0.182432,0,80,unavailable,2,0.7,0.4,"bone marrow: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178404,CEP295NL,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.2308% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); amygdala: 78.2609% (minimum 99%, Missing); basal ganglia: 85.7143% (minimum 99%, Missing); bone marrow: 66.6667% (minimum 99%, Missing); cerebellum: 58.0645% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 85.7143% (minimum 99%, Missing); colon: 56.2500% (minimum 97%, Missing); duodenum: 60.0000% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 64.2857% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 81.8182% (minimum 99%, Missing); kidney: 62.0690% (minimum 99%, Missing); liver: 72.0000% (minimum 99%, Missing); lung: 69.2308% (minimum 99%, Missing); lymph node: 69.2308% (minimum 97%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 54.5455% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); pituitary gland: 69.2308% (minimum 99%, Missing); rectum: 54.5455% (minimum 97%, Missing); retina: 69.2308% (minimum 99%, Missing); salivary gland: 56.2500% (minimum 97%, Missing); skeletal muscle: 60.0000% (minimum 99%, Uncertain); skin: 75.0000% (minimum 95%, Missing); small intestine: 64.2857% (minimum 99%, Missing); smooth muscle: 72.0000% (minimum 99%, Missing); spinal cord: 85.7143% (minimum 99%, Missing); spleen: 78.2609% (minimum 95%, Uncertain); stomach: 48.6486% (minimum 97%, Missing); thymus: 64.2857% (minimum 95%, Missing); thyroid gland: 69.2308% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 72.0000% (minimum 97%, Uncertain)",-0.307143,-0.483514,-0.444545,0,1,partial,1.5,1.9,1,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178409,BEND3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); cerebellum: 58.0645% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 56.2500% (minimum 70%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 64.2857% (minimum 75%, Missing); kidney: 62.0690% (minimum 75%, Missing); liver: 72.0000% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); lymph node: 69.2308% (minimum 70%, Missing); pancreas: 54.5455% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); rectum: 54.5455% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); salivary gland: 56.2500% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Uncertain); small intestine: 64.2857% (minimum 75%, Missing); smooth muscle: 72.0000% (minimum 75%, Missing); stomach: 48.6486% (minimum 70%, Missing); thymus: 64.2857% (minimum 65%, Missing)",-0.00714286,-0.213514,-0.204545,0,1,partial,1.5,1.9,1,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178409,BEND3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); cerebellum: 58.0645% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 56.2500% (minimum 70%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 64.2857% (minimum 75%, Missing); kidney: 62.0690% (minimum 75%, Missing); liver: 72.0000% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); lymph node: 69.2308% (minimum 70%, Missing); pancreas: 54.5455% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); rectum: 54.5455% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); salivary gland: 56.2500% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Uncertain); small intestine: 64.2857% (minimum 75%, Missing); smooth muscle: 72.0000% (minimum 75%, Missing); stomach: 48.6486% (minimum 70%, Missing); thymus: 64.2857% (minimum 65%, Missing)",-0.00714286,-0.213514,-0.204545,0,1,partial,1.5,1.9,1,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178409,BEND3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); cerebellum: 58.0645% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 56.2500% (minimum 70%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 64.2857% (minimum 75%, Missing); kidney: 62.0690% (minimum 75%, Missing); liver: 72.0000% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); lymph node: 69.2308% (minimum 70%, Missing); pancreas: 54.5455% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); rectum: 54.5455% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); salivary gland: 56.2500% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Uncertain); small intestine: 64.2857% (minimum 75%, Missing); smooth muscle: 72.0000% (minimum 75%, Missing); stomach: 48.6486% (minimum 70%, Missing); thymus: 64.2857% (minimum 65%, Missing)",-0.00714286,-0.213514,-0.204545,0,1,partial,1.5,1.9,1,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178409,BEND3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 58.0645% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 75%, Baseline (adaptation disabled)); colon: 56.2500% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.2857% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.0690% (minimum 75%, Baseline (adaptation disabled)); liver: 72.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 69.2308% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.2308% (minimum 70%, Baseline (adaptation disabled)); pancreas: 54.5455% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 69.2308% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.5455% (minimum 70%, Baseline (adaptation disabled)); retina: 69.2308% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.2500% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); small intestine: 64.2857% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.0000% (minimum 75%, Baseline (adaptation disabled)); stomach: 48.6486% (minimum 70%, Baseline (adaptation disabled)); thymus: 64.2857% (minimum 65%, Baseline (adaptation disabled))",-0.00714286,-0.213514,-0.204545,0,1,partial,1.5,1.9,1,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178409,BEND3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.0635% (minimum 95%, Missing); adrenal gland: 86.5672% (minimum 99%, Missing); amygdala: 92.0635% (minimum 99%, Missing); basal ganglia: 89.9225% (minimum 99%, Missing); bone marrow: 73.8854% (minimum 99%, Missing); cerebellum: 87.2180% (minimum 99%, Missing); cerebral cortex: 87.2180% (minimum 99%, Missing); choroid plexus: 97.4790% (minimum 99%, Missing); colon: 94.3089% (minimum 97%, Missing); duodenum: 89.2308% (minimum 99%, Missing); esophagus: 87.8788% (minimum 97%, Missing); heart muscle: 82.8571% (minimum 99%, Missing); hippocampal formation: 93.5484% (minimum 99%, Missing); hypothalamus: 92.0635% (minimum 99%, Missing); kidney: 92.0635% (minimum 99%, Missing); liver: 95.0820% (minimum 99%, Missing); lung: 94.3089% (minimum 99%, Missing); lymph node: 81.1189% (minimum 97%, Missing); midbrain: 92.8000% (minimum 99%, Missing); pancreas: 89.2308% (minimum 99%, Missing); parathyroid gland: 91.3386% (minimum 97%, Missing); pituitary gland: 92.8000% (minimum 99%, Missing); rectum: 94.3089% (minimum 97%, Missing); retina: 72.9560% (minimum 99%, Missing); salivary gland: 89.2308% (minimum 97%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 84.6715% (minimum 95%, Missing); small intestine: 89.9225% (minimum 99%, Missing); spinal cord: 92.0635% (minimum 99%, Missing); spleen: 90.6250% (minimum 95%, Missing); stomach: 92.8000% (minimum 97%, Missing); thyroid gland: 89.2308% (minimum 95%, Missing); tongue: 89.2308% (minimum 97%, Missing); urinary bladder: 94.3089% (minimum 97%, Missing)",-0.103285,-0.158811,-0.323333,0,80,unavailable,5.8,2.7,2.1,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178460,MCMDC2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 73.8854% (minimum 75%, Missing); retina: 72.9560% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing)",0.196715,0.111189,-0.0833333,0,80,unavailable,5.8,2.7,2.1,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178460,MCMDC2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 73.8854% (minimum 75%, Missing); retina: 72.9560% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing)",0.196715,0.111189,-0.0833333,0,80,unavailable,5.8,2.7,2.1,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178460,MCMDC2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 73.8854% (minimum 75%, Missing); retina: 72.9560% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing)",0.196715,0.111189,-0.0833333,0,80,unavailable,5.8,2.7,2.1,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178460,MCMDC2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 73.8854% (minimum 75%, Baseline (adaptation disabled)); retina: 72.9560% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.196715,0.111189,-0.0833333,0,80,unavailable,5.8,2.7,2.1,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178460,MCMDC2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4561% (minimum 95%, Uncertain); adrenal gland: 79.6610% (minimum 99%, Missing); amygdala: 94.0000% (minimum 99%, Missing); basal ganglia: 92.1569% (minimum 99%, Missing); bone marrow: 51.3661% (minimum 99%, Missing); cerebellum: 83.1858% (minimum 99%, Missing); cerebral cortex: 59.4937% (minimum 99%, Missing); choroid plexus: 90.3846% (minimum 99%, Missing); colon: 83.1858% (minimum 97%, Missing); duodenum: 84.6847% (minimum 99%, Missing); esophagus: 84.6847% (minimum 97%, Uncertain); heart muscle: 83.1858% (minimum 99%, Missing); hippocampal formation: 93.0693% (minimum 99%, Missing); hypothalamus: 90.3846% (minimum 99%, Missing); kidney: 78.9916% (minimum 99%, Missing); liver: 79.6610% (minimum 99%, Missing); lung: 81.0345% (minimum 99%, Uncertain); lymph node: 77.0492% (minimum 97%, Uncertain); midbrain: 94.0000% (minimum 99%, Missing); pancreas: 76.4228% (minimum 99%, Missing); parathyroid gland: 68.1159% (minimum 97%, Missing); pituitary gland: 93.0693% (minimum 99%, Missing); rectum: 84.6847% (minimum 97%, Missing); retina: 58.0247% (minimum 99%, Missing); salivary gland: 81.0345% (minimum 97%, Missing); skeletal muscle: 69.6296% (minimum 99%, Missing); skin: 75.2000% (minimum 95%, Missing); small intestine: 84.6847% (minimum 99%, Missing); smooth muscle: 84.6847% (minimum 99%, Uncertain); spinal cord: 93.0693% (minimum 99%, Missing); spleen: 77.6860% (minimum 95%, Missing); stomach: 81.0345% (minimum 97%, Missing); thymus: 77.6860% (minimum 95%, Missing); thyroid gland: 68.6131% (minimum 95%, Missing); tongue: 83.9286% (minimum 97%, Missing); urinary bladder: 86.2385% (minimum 97%, Missing)",-0.263869,-0.288841,-0.476339,0,0,routine_complete,8.9,4.4,4.3,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178502,KLHL11,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 51.3661% (minimum 75%, Missing); cerebral cortex: 59.4937% (minimum 75%, Missing); parathyroid gland: 68.1159% (minimum 70%, Missing); retina: 58.0247% (minimum 75%, Missing); skeletal muscle: 69.6296% (minimum 75%, Missing)",0.0361314,-0.0188406,-0.236339,0,0,routine_complete,8.9,4.4,4.3,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178502,KLHL11,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 51.3661% (minimum 75%, Missing); cerebral cortex: 59.4937% (minimum 75%, Missing); parathyroid gland: 68.1159% (minimum 70%, Missing); retina: 58.0247% (minimum 75%, Missing); skeletal muscle: 69.6296% (minimum 75%, Missing)",0.0361314,-0.0188406,-0.236339,0,0,routine_complete,8.9,4.4,4.3,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 3); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178502,KLHL11,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 51.3661% (minimum 75%, Missing); cerebral cortex: 59.4937% (minimum 75%, Missing); parathyroid gland: 68.1159% (minimum 70%, Missing); retina: 58.0247% (minimum 75%, Missing); skeletal muscle: 69.6296% (minimum 75%, Missing)",0.0361314,-0.0188406,-0.236339,0,0,routine_complete,8.9,4.4,4.3,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 3); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178502,KLHL11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 51.3661% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 59.4937% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 68.1159% (minimum 70%, Baseline (adaptation disabled)); retina: 58.0247% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 69.6296% (minimum 75%, Baseline (adaptation disabled))",0.0361314,-0.0188406,-0.236339,0,0,routine_complete,8.9,4.4,4.3,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 3); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178502,KLHL11,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.2298% (minimum 95%, Missing); adrenal gland: 71.4286% (minimum 99%, Missing); amygdala: 80.1282% (minimum 99%, Missing); basal ganglia: 84.0807% (minimum 99%, Missing); bone marrow: 90.3614% (minimum 99%, Missing); cerebellum: 78.7815% (minimum 99%, Missing); cerebral cortex: 77.8008% (minimum 99%, Missing); choroid plexus: 88.0282% (minimum 99%, Missing); colon: 77.3196% (minimum 97%, Missing); duodenum: 35.4108% (minimum 99%, Missing); esophagus: 63.0252% (minimum 97%, Missing); heart muscle: 85.0340% (minimum 99%, Missing); hippocampal formation: 83.1486% (minimum 99%, Missing); hypothalamus: 85.8124% (minimum 99%, Missing); kidney: 44.6429% (minimum 99%, Missing); liver: 60.0000% (minimum 99%, Missing); lung: 67.3250% (minimum 99%, Missing); lymph node: 55.3914% (minimum 97%, Missing); midbrain: 81.1688% (minimum 99%, Missing); pancreas: 92.3645% (minimum 99%, Missing); parathyroid gland: 43.2526% (minimum 97%, Missing); pituitary gland: 88.0282% (minimum 99%, Missing); rectum: 78.2881% (minimum 97%, Missing); retina: 89.2857% (minimum 99%, Missing); salivary gland: 76.5306% (minimum 97%, Missing); skeletal muscle: 43.9625% (minimum 99%, Missing); skin: 39.9787% (minimum 95%, Missing); small intestine: 31.7259% (minimum 99%, Missing); smooth muscle: 68.5558% (minimum 99%, Missing); spinal cord: 76.0649% (minimum 99%, Missing); spleen: 59.7134% (minimum 95%, Missing); stomach: 74.7012% (minimum 97%, Missing); thymus: 68.3060% (minimum 95%, Missing); thyroid gland: 62.6043% (minimum 95%, Missing); tongue: 66.3717% (minimum 97%, Missing); urinary bladder: 68.6813% (minimum 97%, Missing)",-0.550213,-0.537474,-0.672741,0,0,routine_complete,80.7,49.2,56.3,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); skin: 56.3 nTPM (manageable, limit 5); parathyroid gland: 49.2 nTPM (protected, limit 2); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 2); adipose tissue: 26.9 nTPM (manageable, limit 5); spleen: 25.3 nTPM (manageable, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (manageable, limit 5); esophagus: 22 nTPM (protected, limit 2); tongue: 19 nTPM (protected, limit 2); lung: 18.2 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 2); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); spinal cord: 11.8 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); colon: 11 nTPM (protected, limit 2); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 2); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178573,MAF,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.2298% (minimum 65%, Missing); adrenal gland: 71.4286% (minimum 75%, Missing); duodenum: 35.4108% (minimum 75%, Missing); esophagus: 63.0252% (minimum 70%, Missing); kidney: 44.6429% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 67.3250% (minimum 75%, Missing); lymph node: 55.3914% (minimum 70%, Missing); parathyroid gland: 43.2526% (minimum 70%, Missing); skeletal muscle: 43.9625% (minimum 75%, Missing); skin: 39.9787% (minimum 65%, Missing); small intestine: 31.7259% (minimum 75%, Missing); smooth muscle: 68.5558% (minimum 75%, Missing); spleen: 59.7134% (minimum 65%, Missing); thyroid gland: 62.6043% (minimum 65%, Missing); tongue: 66.3717% (minimum 70%, Missing); urinary bladder: 68.6813% (minimum 70%, Missing)",-0.250213,-0.267474,-0.432741,0,0,routine_complete,80.7,49.2,56.3,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); skin: 56.3 nTPM (manageable, limit 5); parathyroid gland: 49.2 nTPM (protected, limit 2); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 2); adipose tissue: 26.9 nTPM (manageable, limit 5); spleen: 25.3 nTPM (manageable, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (manageable, limit 5); esophagus: 22 nTPM (protected, limit 2); tongue: 19 nTPM (protected, limit 2); lung: 18.2 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 2); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); spinal cord: 11.8 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); colon: 11 nTPM (protected, limit 2); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 2); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178573,MAF,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.2298% (minimum 65%, Missing); adrenal gland: 71.4286% (minimum 75%, Missing); duodenum: 35.4108% (minimum 75%, Missing); esophagus: 63.0252% (minimum 70%, Missing); kidney: 44.6429% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 67.3250% (minimum 75%, Missing); lymph node: 55.3914% (minimum 70%, Missing); parathyroid gland: 43.2526% (minimum 70%, Missing); skeletal muscle: 43.9625% (minimum 75%, Missing); skin: 39.9787% (minimum 65%, Missing); small intestine: 31.7259% (minimum 75%, Missing); smooth muscle: 68.5558% (minimum 75%, Missing); spleen: 59.7134% (minimum 65%, Missing); thyroid gland: 62.6043% (minimum 65%, Missing); tongue: 66.3717% (minimum 70%, Missing); urinary bladder: 68.6813% (minimum 70%, Missing)",-0.250213,-0.267474,-0.432741,0,0,routine_complete,80.7,49.2,56.3,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); skin: 56.3 nTPM (manageable, limit 5); parathyroid gland: 49.2 nTPM (protected, limit 3); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 3); adipose tissue: 26.9 nTPM (manageable, limit 5); spleen: 25.3 nTPM (manageable, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (manageable, limit 5); esophagus: 22 nTPM (protected, limit 3); tongue: 19 nTPM (protected, limit 3); lung: 18.2 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 3); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 3); spinal cord: 11.8 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); colon: 11 nTPM (protected, limit 3); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 3); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178573,MAF,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.2298% (minimum 65%, Missing); adrenal gland: 71.4286% (minimum 75%, Missing); duodenum: 35.4108% (minimum 75%, Missing); esophagus: 63.0252% (minimum 70%, Missing); kidney: 44.6429% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 67.3250% (minimum 75%, Missing); lymph node: 55.3914% (minimum 70%, Missing); parathyroid gland: 43.2526% (minimum 70%, Missing); skeletal muscle: 43.9625% (minimum 75%, Missing); skin: 39.9787% (minimum 65%, Missing); small intestine: 31.7259% (minimum 75%, Missing); smooth muscle: 68.5558% (minimum 75%, Missing); spleen: 59.7134% (minimum 65%, Missing); thyroid gland: 62.6043% (minimum 65%, Missing); tongue: 66.3717% (minimum 70%, Missing); urinary bladder: 68.6813% (minimum 70%, Missing)",-0.250213,-0.267474,-0.432741,0,0,routine_complete,80.7,49.2,56.3,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); skin: 56.3 nTPM (manageable, limit 5); parathyroid gland: 49.2 nTPM (protected, limit 3); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 3); adipose tissue: 26.9 nTPM (manageable, limit 5); spleen: 25.3 nTPM (manageable, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (manageable, limit 5); esophagus: 22 nTPM (protected, limit 3); tongue: 19 nTPM (protected, limit 3); lung: 18.2 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 3); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 3); spinal cord: 11.8 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); colon: 11 nTPM (protected, limit 3); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 3); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178573,MAF,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.2298% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 71.4286% (minimum 75%, Baseline (adaptation disabled)); duodenum: 35.4108% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.0252% (minimum 70%, Baseline (adaptation disabled)); kidney: 44.6429% (minimum 75%, Baseline (adaptation disabled)); liver: 60.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 67.3250% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.3914% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 43.2526% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 43.9625% (minimum 75%, Baseline (adaptation disabled)); skin: 39.9787% (minimum 65%, Baseline (adaptation disabled)); small intestine: 31.7259% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.5558% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.7134% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.6043% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.3717% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 68.6813% (minimum 70%, Baseline (adaptation disabled))",-0.250213,-0.267474,-0.432741,0,0,routine_complete,80.7,49.2,56.3,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); skin: 56.3 nTPM (manageable, limit 5); parathyroid gland: 49.2 nTPM (protected, limit 3); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 3); adipose tissue: 26.9 nTPM (manageable, limit 5); spleen: 25.3 nTPM (manageable, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (manageable, limit 5); esophagus: 22 nTPM (protected, limit 3); tongue: 19 nTPM (protected, limit 3); lung: 18.2 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 3); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 3); spinal cord: 11.8 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); colon: 11 nTPM (protected, limit 3); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 3); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178573,MAF,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178591,DEFB125,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178591,DEFB125,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178591,DEFB125,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178591,DEFB125,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178591,DEFB125,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00226804,0,1,partial,0.3,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178645,C10orf53,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242268,0,1,partial,0.3,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178645,C10orf53,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242268,0,1,partial,0.3,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178645,C10orf53,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242268,0,1,partial,0.3,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178645,C10orf53,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342268,0.3,0.242268,0,1,partial,0.3,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178645,C10orf53,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Missing); adrenal gland: 81.8182% (minimum 99%, Missing); amygdala: 69.2308% (minimum 99%, Missing); basal ganglia: 70.5882% (minimum 99%, Missing); bone marrow: 69.2308% (minimum 99%, Missing); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 61.0169% (minimum 99%, Missing); choroid plexus: 80.0000% (minimum 99%, Missing); colon: 85.7143% (minimum 97%, Missing); duodenum: 78.2609% (minimum 99%, Missing); esophagus: 87.8049% (minimum 97%, Missing); heart muscle: 83.7209% (minimum 99%, Missing); hippocampal formation: 69.2308% (minimum 99%, Missing); hypothalamus: 70.5882% (minimum 99%, Missing); kidney: 78.2609% (minimum 99%, Missing); liver: 85.7143% (minimum 99%, Missing); lung: 83.7209% (minimum 99%, Missing); lymph node: 85.7143% (minimum 97%, Missing); midbrain: 69.2308% (minimum 99%, Missing); pancreas: 75.0000% (minimum 99%, Missing); parathyroid gland: 85.7143% (minimum 97%, Missing); pituitary gland: 67.9245% (minimum 99%, Missing); rectum: 87.8049% (minimum 97%, Missing); retina: 61.0169% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 67.9245% (minimum 99%, Missing); skin: 76.5957% (minimum 95%, Missing); small intestine: 85.7143% (minimum 99%, Missing); smooth muscle: 78.2609% (minimum 99%, Missing); spinal cord: 57.1429% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 72.0000% (minimum 97%, Missing); thymus: 72.0000% (minimum 95%, Missing); thyroid gland: 73.4694% (minimum 95%, Missing); tongue: 83.7209% (minimum 97%, Missing); urinary bladder: 90.0000% (minimum 97%, Missing)",-0.23,-0.25,-0.418571,0,80,unavailable,2.7,1.4,1.4,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178665,ZNF713,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 75%, Missing); basal ganglia: 70.5882% (minimum 75%, Missing); bone marrow: 69.2308% (minimum 75%, Missing); cerebral cortex: 61.0169% (minimum 75%, Missing); hippocampal formation: 69.2308% (minimum 75%, Missing); hypothalamus: 70.5882% (minimum 75%, Missing); midbrain: 69.2308% (minimum 75%, Missing); pituitary gland: 67.9245% (minimum 75%, Missing); retina: 61.0169% (minimum 75%, Missing); skeletal muscle: 67.9245% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing)",0.07,0.02,-0.178571,0,80,unavailable,2.7,1.4,1.4,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178665,ZNF713,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 75%, Missing); basal ganglia: 70.5882% (minimum 75%, Missing); bone marrow: 69.2308% (minimum 75%, Missing); cerebral cortex: 61.0169% (minimum 75%, Missing); hippocampal formation: 69.2308% (minimum 75%, Missing); hypothalamus: 70.5882% (minimum 75%, Missing); midbrain: 69.2308% (minimum 75%, Missing); pituitary gland: 67.9245% (minimum 75%, Missing); retina: 61.0169% (minimum 75%, Missing); skeletal muscle: 67.9245% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing)",0.07,0.02,-0.178571,0,80,unavailable,2.7,1.4,1.4,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178665,ZNF713,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 75%, Missing); basal ganglia: 70.5882% (minimum 75%, Missing); bone marrow: 69.2308% (minimum 75%, Missing); cerebral cortex: 61.0169% (minimum 75%, Missing); hippocampal formation: 69.2308% (minimum 75%, Missing); hypothalamus: 70.5882% (minimum 75%, Missing); midbrain: 69.2308% (minimum 75%, Missing); pituitary gland: 67.9245% (minimum 75%, Missing); retina: 61.0169% (minimum 75%, Missing); skeletal muscle: 67.9245% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing)",0.07,0.02,-0.178571,0,80,unavailable,2.7,1.4,1.4,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178665,ZNF713,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.5882% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 69.2308% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.0169% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 69.2308% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 70.5882% (minimum 75%, Baseline (adaptation disabled)); midbrain: 69.2308% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 67.9245% (minimum 75%, Baseline (adaptation disabled)); retina: 61.0169% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 67.9245% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.1429% (minimum 75%, Baseline (adaptation disabled))",0.07,0.02,-0.178571,0,80,unavailable,2.7,1.4,1.4,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178665,ZNF713,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.1429% (minimum 95%, Missing); adrenal gland: 54.2373% (minimum 99%, Missing); amygdala: 62.7451% (minimum 99%, Missing); basal ganglia: 53.3333% (minimum 99%, Missing); bone marrow: 47.0588% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 60.3774% (minimum 99%, Missing); choroid plexus: 72.7273% (minimum 99%, Missing); colon: 48.4848% (minimum 97%, Missing); duodenum: 51.6129% (minimum 99%, Missing); esophagus: 59.2593% (minimum 97%, Missing); heart muscle: 58.1818% (minimum 99%, Missing); hippocampal formation: 60.3774% (minimum 99%, Missing); hypothalamus: 59.2593% (minimum 99%, Missing); kidney: 58.1818% (minimum 99%, Missing); liver: 51.6129% (minimum 99%, Missing); lung: 55.1724% (minimum 99%, Missing); lymph node: 50.7937% (minimum 97%, Missing); midbrain: 60.3774% (minimum 99%, Missing); pancreas: 51.6129% (minimum 99%, Missing); parathyroid gland: 59.2593% (minimum 97%, Missing); pituitary gland: 59.2593% (minimum 99%, Missing); rectum: 45.7143% (minimum 97%, Missing); retina: 49.2308% (minimum 99%, Missing); salivary gland: 55.1724% (minimum 97%, Missing); skeletal muscle: 74.4186% (minimum 99%, Missing); skin: 50.7937% (minimum 95%, Missing); small intestine: 52.4590% (minimum 99%, Missing); smooth muscle: 57.1429% (minimum 99%, Missing); spinal cord: 58.1818% (minimum 99%, Missing); spleen: 48.4848% (minimum 95%, Missing); stomach: 50.7937% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing); thyroid gland: 52.4590% (minimum 95%, Missing); tongue: 71.1111% (minimum 97%, Missing); urinary bladder: 56.1404% (minimum 97%, Missing)",-0.465152,-0.512857,-0.519412,0,80,unavailable,3.6,3.8,3.4,"rectum: 3.8 nTPM (protected, limit 2); bone marrow: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178694,NSUN3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.1429% (minimum 65%, Missing); adrenal gland: 54.2373% (minimum 75%, Missing); amygdala: 62.7451% (minimum 75%, Missing); basal ganglia: 53.3333% (minimum 75%, Missing); bone marrow: 47.0588% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 60.3774% (minimum 75%, Missing); choroid plexus: 72.7273% (minimum 75%, Missing); colon: 48.4848% (minimum 70%, Missing); duodenum: 51.6129% (minimum 75%, Missing); esophagus: 59.2593% (minimum 70%, Missing); heart muscle: 58.1818% (minimum 75%, Missing); hippocampal formation: 60.3774% (minimum 75%, Missing); hypothalamus: 59.2593% (minimum 75%, Missing); kidney: 58.1818% (minimum 75%, Missing); liver: 51.6129% (minimum 75%, Missing); lung: 55.1724% (minimum 75%, Missing); lymph node: 50.7937% (minimum 70%, Missing); midbrain: 60.3774% (minimum 75%, Missing); pancreas: 51.6129% (minimum 75%, Missing); parathyroid gland: 59.2593% (minimum 70%, Missing); pituitary gland: 59.2593% (minimum 75%, Missing); rectum: 45.7143% (minimum 70%, Missing); retina: 49.2308% (minimum 75%, Missing); salivary gland: 55.1724% (minimum 70%, Missing); skeletal muscle: 74.4186% (minimum 75%, Missing); skin: 50.7937% (minimum 65%, Missing); small intestine: 52.4590% (minimum 75%, Missing); smooth muscle: 57.1429% (minimum 75%, Missing); spinal cord: 58.1818% (minimum 75%, Missing); spleen: 48.4848% (minimum 65%, Missing); stomach: 50.7937% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 52.4590% (minimum 65%, Missing); urinary bladder: 56.1404% (minimum 70%, Missing)",-0.165152,-0.242857,-0.279412,0,80,unavailable,3.6,3.8,3.4,"rectum: 3.8 nTPM (protected, limit 2); bone marrow: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178694,NSUN3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.1429% (minimum 65%, Missing); adrenal gland: 54.2373% (minimum 75%, Missing); amygdala: 62.7451% (minimum 75%, Missing); basal ganglia: 53.3333% (minimum 75%, Missing); bone marrow: 47.0588% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 60.3774% (minimum 75%, Missing); choroid plexus: 72.7273% (minimum 75%, Missing); colon: 48.4848% (minimum 70%, Missing); duodenum: 51.6129% (minimum 75%, Missing); esophagus: 59.2593% (minimum 70%, Missing); heart muscle: 58.1818% (minimum 75%, Missing); hippocampal formation: 60.3774% (minimum 75%, Missing); hypothalamus: 59.2593% (minimum 75%, Missing); kidney: 58.1818% (minimum 75%, Missing); liver: 51.6129% (minimum 75%, Missing); lung: 55.1724% (minimum 75%, Missing); lymph node: 50.7937% (minimum 70%, Missing); midbrain: 60.3774% (minimum 75%, Missing); pancreas: 51.6129% (minimum 75%, Missing); parathyroid gland: 59.2593% (minimum 70%, Missing); pituitary gland: 59.2593% (minimum 75%, Missing); rectum: 45.7143% (minimum 70%, Missing); retina: 49.2308% (minimum 75%, Missing); salivary gland: 55.1724% (minimum 70%, Missing); skeletal muscle: 74.4186% (minimum 75%, Missing); skin: 50.7937% (minimum 65%, Missing); small intestine: 52.4590% (minimum 75%, Missing); smooth muscle: 57.1429% (minimum 75%, Missing); spinal cord: 58.1818% (minimum 75%, Missing); spleen: 48.4848% (minimum 65%, Missing); stomach: 50.7937% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 52.4590% (minimum 65%, Missing); urinary bladder: 56.1404% (minimum 70%, Missing)",-0.165152,-0.242857,-0.279412,0,80,unavailable,3.6,3.8,3.4,"rectum: 3.8 nTPM (protected, limit 3); bone marrow: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178694,NSUN3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.1429% (minimum 65%, Missing); adrenal gland: 54.2373% (minimum 75%, Missing); amygdala: 62.7451% (minimum 75%, Missing); basal ganglia: 53.3333% (minimum 75%, Missing); bone marrow: 47.0588% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 60.3774% (minimum 75%, Missing); choroid plexus: 72.7273% (minimum 75%, Missing); colon: 48.4848% (minimum 70%, Missing); duodenum: 51.6129% (minimum 75%, Missing); esophagus: 59.2593% (minimum 70%, Missing); heart muscle: 58.1818% (minimum 75%, Missing); hippocampal formation: 60.3774% (minimum 75%, Missing); hypothalamus: 59.2593% (minimum 75%, Missing); kidney: 58.1818% (minimum 75%, Missing); liver: 51.6129% (minimum 75%, Missing); lung: 55.1724% (minimum 75%, Missing); lymph node: 50.7937% (minimum 70%, Missing); midbrain: 60.3774% (minimum 75%, Missing); pancreas: 51.6129% (minimum 75%, Missing); parathyroid gland: 59.2593% (minimum 70%, Missing); pituitary gland: 59.2593% (minimum 75%, Missing); rectum: 45.7143% (minimum 70%, Missing); retina: 49.2308% (minimum 75%, Missing); salivary gland: 55.1724% (minimum 70%, Missing); skeletal muscle: 74.4186% (minimum 75%, Missing); skin: 50.7937% (minimum 65%, Missing); small intestine: 52.4590% (minimum 75%, Missing); smooth muscle: 57.1429% (minimum 75%, Missing); spinal cord: 58.1818% (minimum 75%, Missing); spleen: 48.4848% (minimum 65%, Missing); stomach: 50.7937% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 52.4590% (minimum 65%, Missing); urinary bladder: 56.1404% (minimum 70%, Missing)",-0.165152,-0.242857,-0.279412,0,80,unavailable,3.6,3.8,3.4,"rectum: 3.8 nTPM (protected, limit 3); bone marrow: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178694,NSUN3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.1429% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 54.2373% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.7451% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 53.3333% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 47.0588% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.3774% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.7273% (minimum 75%, Baseline (adaptation disabled)); colon: 48.4848% (minimum 70%, Baseline (adaptation disabled)); duodenum: 51.6129% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.2593% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.1818% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 60.3774% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 59.2593% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.1818% (minimum 75%, Baseline (adaptation disabled)); liver: 51.6129% (minimum 75%, Baseline (adaptation disabled)); lung: 55.1724% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.7937% (minimum 70%, Baseline (adaptation disabled)); midbrain: 60.3774% (minimum 75%, Baseline (adaptation disabled)); pancreas: 51.6129% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.2593% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 59.2593% (minimum 75%, Baseline (adaptation disabled)); rectum: 45.7143% (minimum 70%, Baseline (adaptation disabled)); retina: 49.2308% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.1724% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 74.4186% (minimum 75%, Baseline (adaptation disabled)); skin: 50.7937% (minimum 65%, Baseline (adaptation disabled)); small intestine: 52.4590% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.1429% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 58.1818% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.4848% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.7937% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.4590% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 56.1404% (minimum 70%, Baseline (adaptation disabled))",-0.165152,-0.242857,-0.279412,0,80,unavailable,3.6,3.8,3.4,"rectum: 3.8 nTPM (protected, limit 3); bone marrow: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178694,NSUN3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.7368% (minimum 99%, Missing); liver: 85.7143% (minimum 99%, Missing); pituitary gland: 97.2973% (minimum 99%, Missing); retina: 72.0000% (minimum 99%, Missing)",0.022973,0.03,-0.27,0,80,unavailable,1.4,0,0.1,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178795,GDPD4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.0000% (minimum 75%, Missing)",0.322973,0.3,-0.03,0,80,unavailable,1.4,0,0.1,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178795,GDPD4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.0000% (minimum 75%, Missing)",0.322973,0.3,-0.03,0,80,unavailable,1.4,0,0.1,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178795,GDPD4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.0000% (minimum 75%, Missing)",0.322973,0.3,-0.03,0,80,unavailable,1.4,0,0.1,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178795,GDPD4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.0000% (minimum 75%, Baseline (adaptation disabled))",0.322973,0.3,-0.03,0,80,unavailable,1.4,0,0.1,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178795,GDPD4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.1406% (minimum 95%, Enhanced); amygdala: 81.6949% (minimum 99%, Missing); basal ganglia: 70.6745% (minimum 99%, Missing); cerebellum: 92.3372% (minimum 95%, Enhanced); cerebral cortex: 81.6949% (minimum 95%, Enhanced); choroid plexus: 85.4610% (minimum 99%, Missing); colon: 96.0159% (minimum 97%, Missing); hippocampal formation: 79.5380% (minimum 99%, Missing); hypothalamus: 76.7516% (minimum 99%, Missing); lung: 91.2879% (minimum 95%, Enhanced); midbrain: 87.9562% (minimum 99%, Missing); pituitary gland: 41.6235% (minimum 99%, Missing); retina: 83.6806% (minimum 99%, Missing); small intestine: 98.7705% (minimum 99%, Missing); spinal cord: 96.4000% (minimum 99%, Missing)",0.05,-0.00984064,-0.573765,0,10,partial,33.8,1,0,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),82,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178796,RIIAD1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 70.6745% (minimum 75%, Missing); pituitary gland: 41.6235% (minimum 75%, Missing)",0.35,0.260159,-0.333765,0,10,partial,33.8,1,0,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),82,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178796,RIIAD1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 70.6745% (minimum 75%, Missing); pituitary gland: 41.6235% (minimum 75%, Missing)",0.35,0.260159,-0.333765,0,10,partial,33.8,1,0,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),82,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178796,RIIAD1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 70.6745% (minimum 75%, Missing); pituitary gland: 41.6235% (minimum 75%, Missing)",0.35,0.260159,-0.333765,0,10,partial,33.8,1,0,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),82,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178796,RIIAD1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 70.6745% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 41.6235% (minimum 75%, Baseline (adaptation disabled))",0.35,0.260159,-0.333765,0,10,partial,33.8,1,0,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),82,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178796,RIIAD1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,cerebellum / cells in molecular layer: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178804,H1-8,admission_only,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,cerebellum / cells in molecular layer: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178804,H1-8,selectivity_revised,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,cerebellum / cells in molecular layer: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178804,H1-8,grid_revised,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,cerebellum / cells in molecular layer: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178804,H1-8,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,cerebellum / cells in molecular layer: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178804,H1-8,current_fixed,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.4629% (minimum 95%, Missing); adrenal gland: 88.7892% (minimum 99%, Missing); amygdala: 96.5854% (minimum 99%, Missing); basal ganglia: 97.0588% (minimum 99%, Missing); bone marrow: 83.8983% (minimum 99%, Missing); cerebellum: 92.9577% (minimum 99%, Missing); cerebral cortex: 96.1165% (minimum 99%, Missing); colon: 87.6106% (minimum 97%, Missing); duodenum: 81.1475% (minimum 99%, Missing); esophagus: 92.9577% (minimum 97%, Missing); heart muscle: 89.1892% (minimum 99%, Missing); hippocampal formation: 97.0588% (minimum 99%, Missing); hypothalamus: 96.1165% (minimum 99%, Missing); kidney: 79.2000% (minimum 99%, Missing); liver: 85.7143% (minimum 99%, Missing); lung: 86.8421% (minimum 99%, Missing); lymph node: 82.1577% (minimum 97%, Missing); midbrain: 96.1165% (minimum 99%, Missing); pancreas: 92.0930% (minimum 99%, Missing); parathyroid gland: 87.6106% (minimum 97%, Missing); pituitary gland: 88.7892% (minimum 99%, Missing); rectum: 86.0870% (minimum 97%, Missing); retina: 83.8983% (minimum 99%, Missing); salivary gland: 90.0000% (minimum 97%, Missing); skeletal muscle: 96.5854% (minimum 99%, Missing); skin: 90.4110% (minimum 95%, Missing); small intestine: 85.7143% (minimum 99%, Missing); smooth muscle: 89.1892% (minimum 99%, Missing); spinal cord: 95.1923% (minimum 99%, Missing); spleen: 82.1577% (minimum 95%, Missing); stomach: 84.9785% (minimum 97%, Missing); thymus: 92.0930% (minimum 95%, Missing); thyroid gland: 59.2814% (minimum 95%, Missing); urinary bladder: 88.7892% (minimum 97%, Missing)",-0.357186,-0.148423,-0.198,0,80,unavailable,5.2,4.3,13.6,"thyroid gland: 13.6 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); parathyroid gland: 2.8 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178852,EFCAB13,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thyroid gland: 59.2814% (minimum 65%, Missing)",-0.0571856,0.121577,0.042,0,80,unavailable,5.2,4.3,13.6,"thyroid gland: 13.6 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); parathyroid gland: 2.8 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178852,EFCAB13,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thyroid gland: 59.2814% (minimum 65%, Missing)",-0.0571856,0.121577,0.042,0,80,unavailable,5.2,4.3,13.6,"thyroid gland: 13.6 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 3); bone marrow: 3.8 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178852,EFCAB13,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thyroid gland: 59.2814% (minimum 65%, Missing)",-0.0571856,0.121577,0.042,0,80,unavailable,5.2,4.3,13.6,"thyroid gland: 13.6 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 3); bone marrow: 3.8 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178852,EFCAB13,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thyroid gland: 59.2814% (minimum 65%, Baseline (adaptation disabled))",-0.0571856,0.121577,0.042,0,80,unavailable,5.2,4.3,13.6,"thyroid gland: 13.6 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 3); bone marrow: 3.8 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178852,EFCAB13,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 99%, Missing)",0.05,0.03,-0.49,0,80,unavailable,1.1,0,0,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178928,TPRX1,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1.1,0,0,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178928,TPRX1,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1.1,0,0,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178928,TPRX1,grid_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1.1,0,0,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178928,TPRX1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.25,0,80,unavailable,1.1,0,0,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178928,TPRX1,current_fixed,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 98.6395% (minimum 99%, Missing); spinal cord: 97.3154% (minimum 99%, Missing)",0.0363946,0.03,-0.0168456,0,80,unavailable,0.4,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178997,EXD1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.336395,0.3,0.223154,0,80,unavailable,0.4,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178997,EXD1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.336395,0.3,0.223154,0,80,unavailable,0.4,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178997,EXD1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.336395,0.3,0.223154,0,80,unavailable,0.4,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178997,EXD1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.336395,0.3,0.223154,0,80,unavailable,0.4,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000178997,EXD1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.3659% (minimum 99%, Missing); choroid plexus: 97.2222% (minimum 99%, Missing); colon: 96.3303% (minimum 97%, Missing); duodenum: 98.1308% (minimum 99%, Missing); hypothalamus: 94.5946% (minimum 99%, Missing); parathyroid gland: 96.3303% (minimum 97%, Missing); pituitary gland: 69.0789% (minimum 99%, Missing); retina: 80.1527% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 78.3582% (minimum 99%, Missing); tongue: 75.0000% (minimum 97%, Missing)",0.0222222,-0.27,-0.299211,0,80,unavailable,4.7,4.5,0.3,"pituitary gland: 4.7 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179008,C14orf39,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 69.0789% (minimum 75%, Missing)",0.322222,0,-0.0592105,0,80,unavailable,4.7,4.5,0.3,"pituitary gland: 4.7 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179008,C14orf39,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 69.0789% (minimum 75%, Missing)",0.322222,0,-0.0592105,0,80,unavailable,4.7,4.5,0.3,"pituitary gland: 4.7 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179008,C14orf39,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 69.0789% (minimum 75%, Missing)",0.322222,0,-0.0592105,0,80,unavailable,4.7,4.5,0.3,"pituitary gland: 4.7 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179008,C14orf39,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 69.0789% (minimum 75%, Baseline (adaptation disabled))",0.322222,0,-0.0592105,0,80,unavailable,4.7,4.5,0.3,"pituitary gland: 4.7 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179008,C14orf39,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.5000% (minimum 99%, Missing); basal ganglia: 90.6977% (minimum 99%, Missing); cerebral cortex: 95.1220% (minimum 99%, Missing); lung: 97.5000% (minimum 99%, Missing)",0.05,0.005,-0.0830233,0,80,unavailable,0.4,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179046,TRIML2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.275,0.156977,0,80,unavailable,0.4,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179046,TRIML2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.275,0.156977,0,80,unavailable,0.4,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179046,TRIML2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.275,0.156977,0,80,unavailable,0.4,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179046,TRIML2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.275,0.156977,0,80,unavailable,0.4,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179046,TRIML2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179055,OR13D1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179055,OR13D1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179055,OR13D1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179055,OR13D1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179055,OR13D1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 95.2381% (minimum 99%, Missing); bone marrow: 80.0000% (minimum 99%, Missing); cerebral cortex: 95.2381% (minimum 99%, Missing); choroid plexus: 95.2381% (minimum 99%, Missing); colon: 95.2381% (minimum 97%, Missing); duodenum: 90.9091% (minimum 99%, Missing); esophagus: 95.2381% (minimum 97%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 83.3333% (minimum 97%, Missing); rectum: 95.2381% (minimum 97%, Missing); retina: 95.2381% (minimum 99%, Missing); salivary gland: 95.2381% (minimum 97%, Missing); skeletal muscle: 74.0741% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); smooth muscle: 95.2381% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 95.2381% (minimum 97%, Missing); urinary bladder: 95.2381% (minimum 97%, Missing)",-0.15,-0.136667,-0.249259,0,80,unavailable,0.7,0.4,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179059,ZFP42,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 74.0741% (minimum 75%, Missing)",0.15,0.133333,-0.00925926,0,80,unavailable,0.7,0.4,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179059,ZFP42,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 74.0741% (minimum 75%, Missing)",0.15,0.133333,-0.00925926,0,80,unavailable,0.7,0.4,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179059,ZFP42,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 74.0741% (minimum 75%, Missing)",0.15,0.133333,-0.00925926,0,80,unavailable,0.7,0.4,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179059,ZFP42,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 74.0741% (minimum 75%, Baseline (adaptation disabled))",0.15,0.133333,-0.00925926,0,80,unavailable,0.7,0.4,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179059,ZFP42,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.9215% (minimum 99%, Missing); amygdala: 98.6047% (minimum 99%, Missing); basal ganglia: 97.4713% (minimum 99%, Missing); choroid plexus: 97.6959% (minimum 99%, Missing); hippocampal formation: 98.1481% (minimum 99%, Missing); hypothalamus: 97.6959% (minimum 99%, Missing); kidney: 97.4713% (minimum 99%, Missing); midbrain: 98.1481% (minimum 99%, Missing); pituitary gland: 97.2477% (minimum 99%, Missing); retina: 96.3636% (minimum 99%, Missing); smooth muscle: 96.5831% (minimum 99%, Missing); spinal cord: 98.3759% (minimum 99%, Missing)",0.0406542,0.0137587,-0.0263636,0,5,partial,1.6,1.2,0.6,"retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179071,CCDC89,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.340654,0.283759,0.213636,0,5,partial,1.6,1.2,0.6,"retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179071,CCDC89,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.340654,0.283759,0.213636,0,5,partial,1.6,1.2,0.6,"retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179071,CCDC89,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.340654,0.283759,0.213636,0,5,partial,1.6,1.2,0.6,"retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179071,CCDC89,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.336047,0.272477,0.213636,0,5,partial,1.6,1.2,0.6,"retina: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179071,CCDC89,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 86.2069% (minimum 99%, Missing); amygdala: 73.5294% (minimum 99%, Missing); basal ganglia: 61.4754% (minimum 99%, Missing); cerebellum: 77.3196% (minimum 99%, Missing); cerebral cortex: 70.7547% (minimum 99%, Missing); choroid plexus: 94.9367% (minimum 99%, Missing); heart muscle: 89.2857% (minimum 99%, Missing); hippocampal formation: 76.5306% (minimum 99%, Missing); hypothalamus: 61.9835% (minimum 99%, Missing); midbrain: 76.5306% (minimum 99%, Missing); pituitary gland: 78.1250% (minimum 99%, Missing); retina: 85.2273% (minimum 99%, Missing); smooth muscle: 97.4026% (minimum 99%, Missing); spinal cord: 75.7576% (minimum 99%, Missing)",0.024026,0.0168421,-0.375246,0,80,unavailable,4.7,0.1,0.2,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179083,FAM133A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 73.5294% (minimum 75%, Missing); basal ganglia: 61.4754% (minimum 75%, Missing); cerebral cortex: 70.7547% (minimum 75%, Missing); hypothalamus: 61.9835% (minimum 75%, Missing)",0.324026,0.286842,-0.135246,0,80,unavailable,4.7,0.1,0.2,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179083,FAM133A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 73.5294% (minimum 75%, Missing); basal ganglia: 61.4754% (minimum 75%, Missing); cerebral cortex: 70.7547% (minimum 75%, Missing); hypothalamus: 61.9835% (minimum 75%, Missing)",0.324026,0.286842,-0.135246,0,80,unavailable,4.7,0.1,0.2,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179083,FAM133A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 73.5294% (minimum 75%, Missing); basal ganglia: 61.4754% (minimum 75%, Missing); cerebral cortex: 70.7547% (minimum 75%, Missing); hypothalamus: 61.9835% (minimum 75%, Missing)",0.324026,0.286842,-0.135246,0,80,unavailable,4.7,0.1,0.2,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179083,FAM133A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 73.5294% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.4754% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.7547% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.9835% (minimum 75%, Baseline (adaptation disabled))",0.324026,0.286842,-0.135246,0,80,unavailable,4.7,0.1,0.2,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179083,FAM133A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 95.4286% (minimum 97%, Missing); small intestine: 97.6608% (minimum 99%, Missing); spleen: 94.3503% (minimum 95%, Missing); thymus: 92.7778% (minimum 95%, Missing)",-0.0222222,-0.0157143,-0.0133918,0,80,unavailable,0.4,0.8,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179088,C12orf42,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
True,compatible,,True,True,True,,0.277778,0.254286,0.226608,0,80,unavailable,0.4,0.8,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179088,C12orf42,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
True,compatible,,True,True,True,,0.277778,0.254286,0.226608,0,80,unavailable,0.4,0.8,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179088,C12orf42,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
True,compatible,,True,True,True,,0.277778,0.254286,0.226608,0,80,unavailable,0.4,0.8,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179088,C12orf42,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
True,compatible,,True,True,True,,0.277778,0.254286,0.226608,0,80,unavailable,0.4,0.8,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179088,C12orf42,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2381% (minimum 99%, Missing); basal ganglia: 95.2381% (minimum 99%, Missing); bone marrow: 97.5610% (minimum 98%, Approved); cerebral cortex: 96.7742% (minimum 98%, Approved); choroid plexus: 68.5714% (minimum 99%, Missing); duodenum: 96.0000% (minimum 98%, Approved); heart muscle: 95.2381% (minimum 99%, Missing); hippocampal formation: 94.4882% (minimum 99%, Missing); hypothalamus: 95.2381% (minimum 99%, Missing); kidney: 77.9221% (minimum 99%, Missing); liver: 96.7742% (minimum 98%, Approved); lung: 81.0811% (minimum 98%, Approved); midbrain: 96.7742% (minimum 99%, Missing); pituitary gland: 90.9091% (minimum 99%, Missing); retina: 93.7500% (minimum 99%, Missing); skeletal muscle: 96.7742% (minimum 98%, Approved); small intestine: 97.5610% (minimum 98%, Approved); spinal cord: 97.5610% (minimum 99%, Missing)",0.00909091,0.0177419,-0.304286,0,6,partial,5.5,0.4,1.2,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179133,C10orf67,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 68.5714% (minimum 75%, Missing)",0.309091,0.291736,-0.0642857,0,6,partial,5.5,0.4,1.2,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179133,C10orf67,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 68.5714% (minimum 75%, Missing)",0.309091,0.291736,-0.0642857,0,6,partial,5.5,0.4,1.2,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179133,C10orf67,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 68.5714% (minimum 75%, Missing)",0.309091,0.291736,-0.0642857,0,6,partial,5.5,0.4,1.2,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179133,C10orf67,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 68.5714% (minimum 75%, Baseline (adaptation disabled))",0.259091,0.267742,-0.0642857,0,6,partial,5.5,0.4,1.2,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179133,C10orf67,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,0,routine_complete,173.3,0.1,0,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179142,CYP11B2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,0,routine_complete,173.3,0.1,0,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179142,CYP11B2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,0,routine_complete,173.3,0.1,0,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179142,CYP11B2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,0,routine_complete,173.3,0.1,0,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179142,CYP11B2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,0,routine_complete,173.3,0.1,0,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179142,CYP11B2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 95.6522% (minimum 99%, Missing); basal ganglia: 95.6522% (minimum 99%, Missing); bone marrow: 95.6522% (minimum 99%, Missing); cerebellum: 88.0000% (minimum 99%, Missing); cerebral cortex: 95.6522% (minimum 99%, Missing); heart muscle: 95.6522% (minimum 99%, Missing); hippocampal formation: 95.6522% (minimum 99%, Missing); hypothalamus: 95.6522% (minimum 99%, Missing); lung: 95.6522% (minimum 99%, Missing); retina: 95.6522% (minimum 99%, Missing); skeletal muscle: 91.6667% (minimum 99%, Missing); tongue: 95.6522% (minimum 97%, Missing)",0.00652174,-0.0134783,-0.11,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179165,PXT1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.306522,0.256522,0.13,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179165,PXT1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.306522,0.256522,0.13,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179165,PXT1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.306522,0.256522,0.13,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179165,PXT1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.306522,0.256522,0.13,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179165,PXT1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.4227% (minimum 99%, Missing); basal ganglia: 98.7342% (minimum 99%, Missing); cerebral cortex: 97.8056% (minimum 99%, Missing); duodenum: 97.1963% (minimum 99%, Missing); hippocampal formation: 98.1132% (minimum 99%, Missing); hypothalamus: 98.9429% (minimum 99%, Missing); pituitary gland: 98.6301% (minimum 99%, Missing); small intestine: 97.0954% (minimum 99%, Missing)",0.0383844,0.0225769,-0.0190456,0,80,unavailable,2.8,0.7,1.1,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179168,GGN,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338384,0.292577,0.220954,0,80,unavailable,2.8,0.7,1.1,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179168,GGN,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338384,0.292577,0.220954,0,80,unavailable,2.8,0.7,1.1,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179168,GGN,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338384,0.292577,0.220954,0,80,unavailable,2.8,0.7,1.1,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179168,GGN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338384,0.292577,0.220954,0,80,unavailable,2.8,0.7,1.1,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179168,GGN,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179172,HNRNPCL1,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179172,HNRNPCL1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179172,HNRNPCL1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179172,HNRNPCL1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179172,HNRNPCL1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0.1,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179213,SIGLECL1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179213,SIGLECL1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179213,SIGLECL1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179213,SIGLECL1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345,0.3,0.25,0,4,partial,0,0,0.1,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179213,SIGLECL1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.9689% (minimum 95%, Missing); adrenal gland: 56.4854% (minimum 99%, Missing); amygdala: 35.4641% (minimum 99%, Missing); basal ganglia: 35.9043% (minimum 99%, Missing); bone marrow: 49.4505% (minimum 99%, Missing); cerebellum: 57.2034% (minimum 99%, Missing); cerebral cortex: 37.6045% (minimum 99%, Missing); choroid plexus: 63.7795% (minimum 99%, Missing); colon: 56.3282% (minimum 97%, Missing); duodenum: 60.9023% (minimum 99%, Missing); esophagus: 52.1236% (minimum 97%, Missing); heart muscle: 38.5347% (minimum 99%, Missing); hippocampal formation: 36.2254% (minimum 99%, Missing); hypothalamus: 38.9423% (minimum 99%, Missing); kidney: 52.8721% (minimum 99%, Missing); liver: 46.9293% (minimum 99%, Missing); lung: 56.0942% (minimum 99%, Missing); lymph node: 56.0166% (minimum 97%, Missing); midbrain: 29.9335% (minimum 99%, Missing); pancreas: 58.1062% (minimum 99%, Missing); parathyroid gland: 44.2623% (minimum 97%, Missing); pituitary gland: 72.0641% (minimum 99%, Missing); rectum: 58.1897% (minimum 97%, Missing); retina: 46.9838% (minimum 99%, Missing); salivary gland: 64.6965% (minimum 97%, Missing); skeletal muscle: 35.8407% (minimum 98%, Approved); skin: 61.5502% (minimum 95%, Missing); small intestine: 62.4037% (minimum 99%, Missing); smooth muscle: 48.5612% (minimum 99%, Missing); spinal cord: 29.9778% (minimum 99%, Missing); spleen: 62.2120% (minimum 95%, Missing); stomach: 59.0379% (minimum 97%, Missing); thymus: 54.8038% (minimum 95%, Missing); thyroid gland: 47.4239% (minimum 95%, Missing); tongue: 40.0990% (minimum 97%, Missing); urinary bladder: 51.4612% (minimum 97%, Missing)",-0.530311,-0.56901,-0.690665,0,12,partial,94.8,60.5,56,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 2); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 2); adipose tissue: 56 nTPM (manageable, limit 5); parathyroid gland: 51 nTPM (protected, limit 2); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (manageable, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 2); esophagus: 37.2 nTPM (protected, limit 2); kidney: 36.1 nTPM (vital, limit 1); thymus: 33.4 nTPM (manageable, limit 5); lymph node: 31.8 nTPM (protected, limit 2); lung: 31.7 nTPM (vital, limit 1); colon: 31.4 nTPM (protected, limit 2); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 2); stomach: 28.1 nTPM (protected, limit 2); duodenum: 26 nTPM (vital, limit 1); skin: 25.3 nTPM (manageable, limit 5); spleen: 24.6 nTPM (manageable, limit 5); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 2); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179295,PTPN11,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.9689% (minimum 65%, Missing); adrenal gland: 56.4854% (minimum 75%, Missing); amygdala: 35.4641% (minimum 75%, Missing); basal ganglia: 35.9043% (minimum 75%, Missing); bone marrow: 49.4505% (minimum 75%, Missing); cerebellum: 57.2034% (minimum 75%, Missing); cerebral cortex: 37.6045% (minimum 75%, Missing); choroid plexus: 63.7795% (minimum 75%, Missing); colon: 56.3282% (minimum 70%, Missing); duodenum: 60.9023% (minimum 75%, Missing); esophagus: 52.1236% (minimum 70%, Missing); heart muscle: 38.5347% (minimum 75%, Missing); hippocampal formation: 36.2254% (minimum 75%, Missing); hypothalamus: 38.9423% (minimum 75%, Missing); kidney: 52.8721% (minimum 75%, Missing); liver: 46.9293% (minimum 75%, Missing); lung: 56.0942% (minimum 75%, Missing); lymph node: 56.0166% (minimum 70%, Missing); midbrain: 29.9335% (minimum 75%, Missing); pancreas: 58.1062% (minimum 75%, Missing); parathyroid gland: 44.2623% (minimum 70%, Missing); pituitary gland: 72.0641% (minimum 75%, Missing); rectum: 58.1897% (minimum 70%, Missing); retina: 46.9838% (minimum 75%, Missing); salivary gland: 64.6965% (minimum 70%, Missing); skeletal muscle: 35.8407% (minimum 70%, Approved); skin: 61.5502% (minimum 65%, Missing); small intestine: 62.4037% (minimum 75%, Missing); smooth muscle: 48.5612% (minimum 75%, Missing); spinal cord: 29.9778% (minimum 75%, Missing); spleen: 62.2120% (minimum 65%, Missing); stomach: 59.0379% (minimum 70%, Missing); thymus: 54.8038% (minimum 65%, Missing); thyroid gland: 47.4239% (minimum 65%, Missing); tongue: 40.0990% (minimum 70%, Missing); urinary bladder: 51.4612% (minimum 70%, Missing)",-0.230311,-0.29901,-0.450665,0,12,partial,94.8,60.5,56,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 2); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 2); adipose tissue: 56 nTPM (manageable, limit 5); parathyroid gland: 51 nTPM (protected, limit 2); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (manageable, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 2); esophagus: 37.2 nTPM (protected, limit 2); kidney: 36.1 nTPM (vital, limit 1); thymus: 33.4 nTPM (manageable, limit 5); lymph node: 31.8 nTPM (protected, limit 2); lung: 31.7 nTPM (vital, limit 1); colon: 31.4 nTPM (protected, limit 2); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 2); stomach: 28.1 nTPM (protected, limit 2); duodenum: 26 nTPM (vital, limit 1); skin: 25.3 nTPM (manageable, limit 5); spleen: 24.6 nTPM (manageable, limit 5); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 2); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179295,PTPN11,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.9689% (minimum 65%, Missing); adrenal gland: 56.4854% (minimum 75%, Missing); amygdala: 35.4641% (minimum 75%, Missing); basal ganglia: 35.9043% (minimum 75%, Missing); bone marrow: 49.4505% (minimum 75%, Missing); cerebellum: 57.2034% (minimum 75%, Missing); cerebral cortex: 37.6045% (minimum 75%, Missing); choroid plexus: 63.7795% (minimum 75%, Missing); colon: 56.3282% (minimum 70%, Missing); duodenum: 60.9023% (minimum 75%, Missing); esophagus: 52.1236% (minimum 70%, Missing); heart muscle: 38.5347% (minimum 75%, Missing); hippocampal formation: 36.2254% (minimum 75%, Missing); hypothalamus: 38.9423% (minimum 75%, Missing); kidney: 52.8721% (minimum 75%, Missing); liver: 46.9293% (minimum 75%, Missing); lung: 56.0942% (minimum 75%, Missing); lymph node: 56.0166% (minimum 70%, Missing); midbrain: 29.9335% (minimum 75%, Missing); pancreas: 58.1062% (minimum 75%, Missing); parathyroid gland: 44.2623% (minimum 70%, Missing); pituitary gland: 72.0641% (minimum 75%, Missing); rectum: 58.1897% (minimum 70%, Missing); retina: 46.9838% (minimum 75%, Missing); salivary gland: 64.6965% (minimum 70%, Missing); skeletal muscle: 35.8407% (minimum 70%, Approved); skin: 61.5502% (minimum 65%, Missing); small intestine: 62.4037% (minimum 75%, Missing); smooth muscle: 48.5612% (minimum 75%, Missing); spinal cord: 29.9778% (minimum 75%, Missing); spleen: 62.2120% (minimum 65%, Missing); stomach: 59.0379% (minimum 70%, Missing); thymus: 54.8038% (minimum 65%, Missing); thyroid gland: 47.4239% (minimum 65%, Missing); tongue: 40.0990% (minimum 70%, Missing); urinary bladder: 51.4612% (minimum 70%, Missing)",-0.230311,-0.29901,-0.450665,0,12,partial,94.8,60.5,56,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 2); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 3); adipose tissue: 56 nTPM (manageable, limit 5); parathyroid gland: 51 nTPM (protected, limit 3); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (manageable, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 3); esophagus: 37.2 nTPM (protected, limit 3); kidney: 36.1 nTPM (vital, limit 1); thymus: 33.4 nTPM (manageable, limit 5); lymph node: 31.8 nTPM (protected, limit 3); lung: 31.7 nTPM (vital, limit 1); colon: 31.4 nTPM (protected, limit 3); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 3); stomach: 28.1 nTPM (protected, limit 3); duodenum: 26 nTPM (vital, limit 1); skin: 25.3 nTPM (manageable, limit 5); spleen: 24.6 nTPM (manageable, limit 5); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 3); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179295,PTPN11,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.9689% (minimum 65%, Missing); adrenal gland: 56.4854% (minimum 75%, Missing); amygdala: 35.4641% (minimum 75%, Missing); basal ganglia: 35.9043% (minimum 75%, Missing); bone marrow: 49.4505% (minimum 75%, Missing); cerebellum: 57.2034% (minimum 75%, Missing); cerebral cortex: 37.6045% (minimum 75%, Missing); choroid plexus: 63.7795% (minimum 75%, Missing); colon: 56.3282% (minimum 70%, Missing); duodenum: 60.9023% (minimum 75%, Missing); esophagus: 52.1236% (minimum 70%, Missing); heart muscle: 38.5347% (minimum 75%, Missing); hippocampal formation: 36.2254% (minimum 75%, Missing); hypothalamus: 38.9423% (minimum 75%, Missing); kidney: 52.8721% (minimum 75%, Missing); liver: 46.9293% (minimum 75%, Missing); lung: 56.0942% (minimum 75%, Missing); lymph node: 56.0166% (minimum 70%, Missing); midbrain: 29.9335% (minimum 75%, Missing); pancreas: 58.1062% (minimum 75%, Missing); parathyroid gland: 44.2623% (minimum 70%, Missing); pituitary gland: 72.0641% (minimum 75%, Missing); rectum: 58.1897% (minimum 70%, Missing); retina: 46.9838% (minimum 75%, Missing); salivary gland: 64.6965% (minimum 70%, Missing); skeletal muscle: 35.8407% (minimum 70%, Approved); skin: 61.5502% (minimum 65%, Missing); small intestine: 62.4037% (minimum 75%, Missing); smooth muscle: 48.5612% (minimum 75%, Missing); spinal cord: 29.9778% (minimum 75%, Missing); spleen: 62.2120% (minimum 65%, Missing); stomach: 59.0379% (minimum 70%, Missing); thymus: 54.8038% (minimum 65%, Missing); thyroid gland: 47.4239% (minimum 65%, Missing); tongue: 40.0990% (minimum 70%, Missing); urinary bladder: 51.4612% (minimum 70%, Missing)",-0.230311,-0.29901,-0.450665,0,12,partial,94.8,60.5,56,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 2); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 3); adipose tissue: 56 nTPM (manageable, limit 5); parathyroid gland: 51 nTPM (protected, limit 3); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (manageable, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 3); esophagus: 37.2 nTPM (protected, limit 3); kidney: 36.1 nTPM (vital, limit 1); thymus: 33.4 nTPM (manageable, limit 5); lymph node: 31.8 nTPM (protected, limit 3); lung: 31.7 nTPM (vital, limit 1); colon: 31.4 nTPM (protected, limit 3); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 3); stomach: 28.1 nTPM (protected, limit 3); duodenum: 26 nTPM (vital, limit 1); skin: 25.3 nTPM (manageable, limit 5); spleen: 24.6 nTPM (manageable, limit 5); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 3); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179295,PTPN11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.9689% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 56.4854% (minimum 75%, Baseline (adaptation disabled)); amygdala: 35.4641% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 35.9043% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 49.4505% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.2034% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 37.6045% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 63.7795% (minimum 75%, Baseline (adaptation disabled)); colon: 56.3282% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.9023% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.1236% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 38.5347% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 36.2254% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 38.9423% (minimum 75%, Baseline (adaptation disabled)); kidney: 52.8721% (minimum 75%, Baseline (adaptation disabled)); liver: 46.9293% (minimum 75%, Baseline (adaptation disabled)); lung: 56.0942% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.0166% (minimum 70%, Baseline (adaptation disabled)); midbrain: 29.9335% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.1062% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 44.2623% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.0641% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.1897% (minimum 70%, Baseline (adaptation disabled)); retina: 46.9838% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.6965% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 35.8407% (minimum 75%, Baseline (adaptation disabled)); skin: 61.5502% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.4037% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 48.5612% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 29.9778% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.2120% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.0379% (minimum 70%, Baseline (adaptation disabled)); thymus: 54.8038% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 47.4239% (minimum 65%, Baseline (adaptation disabled)); tongue: 40.0990% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.4612% (minimum 70%, Baseline (adaptation disabled))",-0.230311,-0.29901,-0.450665,0,12,partial,94.8,60.5,56,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 1); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 3); adipose tissue: 56 nTPM (manageable, limit 5); parathyroid gland: 51 nTPM (protected, limit 3); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (manageable, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 3); esophagus: 37.2 nTPM (protected, limit 3); kidney: 36.1 nTPM (vital, limit 1); thymus: 33.4 nTPM (manageable, limit 5); lymph node: 31.8 nTPM (protected, limit 3); lung: 31.7 nTPM (vital, limit 1); colon: 31.4 nTPM (protected, limit 3); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 3); stomach: 28.1 nTPM (protected, limit 3); duodenum: 26 nTPM (vital, limit 1); skin: 25.3 nTPM (manageable, limit 5); spleen: 24.6 nTPM (manageable, limit 5); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 3); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179295,PTPN11,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.6746% (minimum 99%, Missing); amygdala: 96.3855% (minimum 99%, Missing); basal ganglia: 95.8084% (minimum 99%, Missing); bone marrow: 96.3855% (minimum 99%, Missing); cerebral cortex: 98.1595% (minimum 99%, Missing); choroid plexus: 62.2568% (minimum 99%, Missing); colon: 85.5615% (minimum 97%, Missing); duodenum: 90.3955% (minimum 99%, Missing); esophagus: 89.8876% (minimum 97%, Missing); heart muscle: 88.8889% (minimum 99%, Missing); hippocampal formation: 96.3855% (minimum 99%, Missing); hypothalamus: 93.0233% (minimum 99%, Missing); kidney: 78.0488% (minimum 99%, Missing); liver: 97.5610% (minimum 99%, Uncertain); lung: 83.3333% (minimum 99%, Missing); midbrain: 96.3855% (minimum 99%, Missing); pancreas: 69.5652% (minimum 99%, Missing); parathyroid gland: 83.3333% (minimum 97%, Missing); pituitary gland: 82.0513% (minimum 99%, Missing); rectum: 87.4317% (minimum 97%, Missing); retina: 95.8084% (minimum 99%, Missing); salivary gland: 77.2947% (minimum 97%, Missing); skin: 91.4286% (minimum 95%, Missing); small intestine: 88.8889% (minimum 99%, Missing); smooth muscle: 93.5673% (minimum 99%, Missing); spinal cord: 98.1595% (minimum 99%, Missing); spleen: 86.0215% (minimum 95%, Uncertain); stomach: 83.7696% (minimum 97%, Missing); thyroid gland: 77.6699% (minimum 95%, Missing); urinary bladder: 92.4855% (minimum 97%, Missing)",-0.173301,-0.197053,-0.367432,0,7,partial,9.7,4.7,4.6,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); stomach: 3.1 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179299,NSUN7,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 62.2568% (minimum 75%, Missing); pancreas: 69.5652% (minimum 75%, Missing)",0.126699,0.0729469,-0.127432,0,7,partial,9.7,4.7,4.6,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); stomach: 3.1 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179299,NSUN7,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 62.2568% (minimum 75%, Missing); pancreas: 69.5652% (minimum 75%, Missing)",0.126699,0.0729469,-0.127432,0,7,partial,9.7,4.7,4.6,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); stomach: 3.1 nTPM (protected, limit 3); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179299,NSUN7,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 62.2568% (minimum 75%, Missing); pancreas: 69.5652% (minimum 75%, Missing)",0.126699,0.0729469,-0.127432,0,7,partial,9.7,4.7,4.6,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); stomach: 3.1 nTPM (protected, limit 3); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179299,NSUN7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 62.2568% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.5652% (minimum 75%, Baseline (adaptation disabled))",0.126699,0.0729469,-0.127432,0,7,partial,9.7,4.7,4.6,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); stomach: 3.1 nTPM (protected, limit 3); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179299,NSUN7,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8909% (minimum 99%, Missing); basal ganglia: 98.4361% (minimum 99%, Missing); hippocampal formation: 98.5267% (minimum 99%, Missing); hypothalamus: 97.9853% (minimum 99%, Missing); midbrain: 98.2553% (minimum 99%, Missing); spinal cord: 97.9853% (minimum 99%, Missing)",0.0462756,0.0179963,-0.0101465,0,80,unavailable,2.2,1.3,0.4,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179363,TMEM31,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346276,0.287996,0.229853,0,80,unavailable,2.2,1.3,0.4,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179363,TMEM31,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346276,0.287996,0.229853,0,80,unavailable,2.2,1.3,0.4,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179363,TMEM31,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346276,0.287996,0.229853,0,80,unavailable,2.2,1.3,0.4,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179363,TMEM31,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346276,0.287996,0.229853,0,80,unavailable,2.2,1.3,0.4,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179363,TMEM31,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.2093% (minimum 99%, Missing); amygdala: 97.6636% (minimum 99%, Missing); basal ganglia: 97.2093% (minimum 99%, Missing); bone marrow: 97.2093% (minimum 99%, Missing); cerebellum: 96.7593% (minimum 99%, Missing); cerebral cortex: 97.6636% (minimum 99%, Missing); choroid plexus: 97.6636% (minimum 99%, Missing); hippocampal formation: 97.6636% (minimum 99%, Missing); hypothalamus: 97.2093% (minimum 99%, Missing); kidney: 95.8716% (minimum 99%, Missing); liver: 97.2093% (minimum 99%, Missing); lung: 97.6636% (minimum 99%, Missing); midbrain: 97.2093% (minimum 99%, Missing); pancreas: 98.1221% (minimum 99%, Missing); parathyroid gland: 96.3134% (minimum 97%, Missing); pituitary gland: 95.4338% (minimum 99%, Missing); retina: 97.2093% (minimum 99%, Missing); skeletal muscle: 97.6636% (minimum 99%, Missing); small intestine: 98.5849% (minimum 99%, Missing); spinal cord: 96.3134% (minimum 99%, Missing)",0.0087156,-0.00686636,-0.0356621,0,80,unavailable,1,0.8,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179397,CATSPERE,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.308716,0.263134,0.204338,0,80,unavailable,1,0.8,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179397,CATSPERE,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.308716,0.263134,0.204338,0,80,unavailable,1,0.8,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179397,CATSPERE,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.308716,0.263134,0.204338,0,80,unavailable,1,0.8,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179397,CATSPERE,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.308716,0.263134,0.204338,0,80,unavailable,1,0.8,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179397,CATSPERE,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179407,DNAJB8,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179407,DNAJB8,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179407,DNAJB8,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179407,DNAJB8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179407,DNAJB8,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179412,HNRNPCL4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179412,HNRNPCL4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179412,HNRNPCL4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179412,HNRNPCL4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179412,HNRNPCL4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179468,OR9A2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179468,OR9A2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179468,OR9A2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179468,OR9A2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179468,OR9A2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.0494598,0.0294598,0.00945975,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179580,RNF151,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34946,0.29946,0.24946,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179580,RNF151,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34946,0.29946,0.24946,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179580,RNF151,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34946,0.29946,0.24946,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179580,RNF151,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34946,0.29946,0.24946,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179580,RNF151,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4000% (minimum 90%, Approved); adrenal gland: 83.7398% (minimum 98%, Approved); amygdala: 77.7358% (minimum 99%, Missing); basal ganglia: 69.1275% (minimum 99%, Missing); bone marrow: 91.1504% (minimum 98%, Approved); cerebellum: 48.8152% (minimum 99%, Missing); cerebral cortex: 73.0496% (minimum 99%, Missing); choroid plexus: 77.7358% (minimum 99%, Missing); colon: 70.3072% (minimum 97%, Missing); duodenum: 92.7928% (minimum 99%, Missing); esophagus: 93.2127% (minimum 97%, Missing); heart muscle: 80.4688% (minimum 99%, Missing); hippocampal formation: 76.8657% (minimum 99%, Missing); hypothalamus: 68.4385% (minimum 99%, Missing); kidney: 88.0342% (minimum 99%, Missing); liver: 78.3270% (minimum 99%, Missing); lung: 88.4120% (minimum 99%, Missing); lymph node: 87.6596% (minimum 97%, Missing); midbrain: 77.4436% (minimum 99%, Missing); pancreas: 81.1024% (minimum 99%, Missing); parathyroid gland: 78.9272% (minimum 97%, Missing); pituitary gland: 72.2807% (minimum 99%, Missing); rectum: 92.3767% (minimum 97%, Missing); retina: 85.8333% (minimum 99%, Missing); salivary gland: 86.9198% (minimum 97%, Missing); skeletal muscle: 80.4688% (minimum 99%, Missing); skin: 82.7309% (minimum 95%, Missing); small intestine: 86.9198% (minimum 99%, Missing); smooth muscle: 89.9563% (minimum 99%, Missing); spinal cord: 79.5367% (minimum 99%, Missing); spleen: 83.0645% (minimum 90%, Approved); stomach: 82.7309% (minimum 97%, Missing); thymus: 93.2127% (minimum 95%, Missing); thyroid gland: 86.5546% (minimum 95%, Missing); tongue: 94.0639% (minimum 97%, Missing); urinary bladder: 83.4008% (minimum 97%, Missing)",-0.122691,-0.266928,-0.501848,0,11,partial,21.6,8.7,4.4,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 2); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); spinal cord: 5.3 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 2); retina: 3.4 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); small intestine: 3.1 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179598,PLD6,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 69.1275% (minimum 75%, Missing); cerebellum: 48.8152% (minimum 75%, Missing); cerebral cortex: 73.0496% (minimum 75%, Missing); hypothalamus: 68.4385% (minimum 75%, Missing); pituitary gland: 72.2807% (minimum 75%, Missing)",0.177309,0.00307167,-0.261848,0,11,partial,21.6,8.7,4.4,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 2); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); spinal cord: 5.3 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 2); retina: 3.4 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); small intestine: 3.1 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179598,PLD6,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 69.1275% (minimum 75%, Missing); cerebellum: 48.8152% (minimum 75%, Missing); cerebral cortex: 73.0496% (minimum 75%, Missing); hypothalamus: 68.4385% (minimum 75%, Missing); pituitary gland: 72.2807% (minimum 75%, Missing)",0.177309,0.00307167,-0.261848,0,11,partial,21.6,8.7,4.4,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 3); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); spinal cord: 5.3 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 3); urinary bladder: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 2); retina: 3.4 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); small intestine: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179598,PLD6,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 69.1275% (minimum 75%, Missing); cerebellum: 48.8152% (minimum 75%, Missing); cerebral cortex: 73.0496% (minimum 75%, Missing); hypothalamus: 68.4385% (minimum 75%, Missing); pituitary gland: 72.2807% (minimum 75%, Missing)",0.177309,0.00307167,-0.261848,0,11,partial,21.6,8.7,4.4,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 3); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); spinal cord: 5.3 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 3); urinary bladder: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 2); retina: 3.4 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); small intestine: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179598,PLD6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 69.1275% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.8152% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.0496% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.4385% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 72.2807% (minimum 75%, Baseline (adaptation disabled))",0.174,0.00307167,-0.261848,0,11,partial,21.6,8.7,4.4,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 3); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); spinal cord: 5.3 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 3); urinary bladder: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); small intestine: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179598,PLD6,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"retina: 50.0000% (minimum 99%, Missing)",0.05,0.03,-0.49,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179600,GPHB5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179600,GPHB5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179600,GPHB5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179600,GPHB5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"retina: 50.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179600,GPHB5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 99%, Missing); amygdala: 72.2222% (minimum 99%, Missing); basal ganglia: 54.1667% (minimum 99%, Missing); cerebellum: 86.6667% (minimum 99%, Missing); cerebral cortex: 38.2353% (minimum 99%, Missing); choroid plexus: 5.8296% (minimum 99%, Missing); colon: 46.4286% (minimum 97%, Missing); heart muscle: 81.2500% (minimum 99%, Missing); hippocampal formation: 68.4211% (minimum 99%, Missing); hypothalamus: 59.0909% (minimum 99%, Missing); kidney: 68.4211% (minimum 99%, Missing); liver: 32.5000% (minimum 99%, Missing); lung: 86.6667% (minimum 99%, Missing); midbrain: 68.4211% (minimum 99%, Missing); pancreas: 76.4706% (minimum 99%, Missing); pituitary gland: 86.6667% (minimum 99%, Missing); rectum: 40.6250% (minimum 97%, Missing); retina: 40.6250% (minimum 99%, Missing); smooth muscle: 92.8571% (minimum 99%, Missing); spinal cord: 86.6667% (minimum 99%, Missing); stomach: 81.2500% (minimum 97%, Missing); thyroid gland: 65.0000% (minimum 95%, Missing); urinary bladder: 76.4706% (minimum 97%, Missing)",-0.3,-0.56375,-0.931704,0,80,unavailable,21,1.9,0.7,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179603,GRM8,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebral cortex: 38.2353% (minimum 75%, Missing); choroid plexus: 5.8296% (minimum 75%, Missing); colon: 46.4286% (minimum 70%, Missing); hippocampal formation: 68.4211% (minimum 75%, Missing); hypothalamus: 59.0909% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); liver: 32.5000% (minimum 75%, Missing); midbrain: 68.4211% (minimum 75%, Missing); rectum: 40.6250% (minimum 70%, Missing); retina: 40.6250% (minimum 75%, Missing)",0,-0.29375,-0.691704,0,80,unavailable,21,1.9,0.7,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179603,GRM8,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebral cortex: 38.2353% (minimum 75%, Missing); choroid plexus: 5.8296% (minimum 75%, Missing); colon: 46.4286% (minimum 70%, Missing); hippocampal formation: 68.4211% (minimum 75%, Missing); hypothalamus: 59.0909% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); liver: 32.5000% (minimum 75%, Missing); midbrain: 68.4211% (minimum 75%, Missing); rectum: 40.6250% (minimum 70%, Missing); retina: 40.6250% (minimum 75%, Missing)",0,-0.29375,-0.691704,0,80,unavailable,21,1.9,0.7,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179603,GRM8,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebral cortex: 38.2353% (minimum 75%, Missing); choroid plexus: 5.8296% (minimum 75%, Missing); colon: 46.4286% (minimum 70%, Missing); hippocampal formation: 68.4211% (minimum 75%, Missing); hypothalamus: 59.0909% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); liver: 32.5000% (minimum 75%, Missing); midbrain: 68.4211% (minimum 75%, Missing); rectum: 40.6250% (minimum 70%, Missing); retina: 40.6250% (minimum 75%, Missing)",0,-0.29375,-0.691704,0,80,unavailable,21,1.9,0.7,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179603,GRM8,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.2222% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.1667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 38.2353% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 5.8296% (minimum 75%, Baseline (adaptation disabled)); colon: 46.4286% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 68.4211% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 59.0909% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.4211% (minimum 75%, Baseline (adaptation disabled)); liver: 32.5000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 68.4211% (minimum 75%, Baseline (adaptation disabled)); rectum: 40.6250% (minimum 70%, Baseline (adaptation disabled)); retina: 40.6250% (minimum 75%, Baseline (adaptation disabled))",0,-0.29375,-0.691704,0,80,unavailable,21,1.9,0.7,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179603,GRM8,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.05,0.012157,0.000863724,0,3,partial,12.8,4.5,0.1,"liver: 12.8 nTPM (vital, limit 6); tongue: 4.5 nTPM (protected, limit 2); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179636,TPPP2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.282157,0.242786,0,3,partial,12.8,4.5,0.1,"liver: 12.8 nTPM (vital, limit 6); tongue: 4.5 nTPM (protected, limit 2); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179636,TPPP2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.282157,0.242786,0,3,partial,12.8,4.5,0.1,"liver: 12.8 nTPM (vital, limit 6); tongue: 4.5 nTPM (protected, limit 3); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179636,TPPP2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.282157,0.242786,0,3,partial,12.8,4.5,0.1,"liver: 12.8 nTPM (vital, limit 6); tongue: 4.5 nTPM (protected, limit 3); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179636,TPPP2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349596,0.282157,0.200864,0,3,partial,12.8,4.5,0.1,"liver: 12.8 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); skeletal muscle: 3.1 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179636,TPPP2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179695,OR6C2,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179695,OR6C2,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179695,OR6C2,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179695,OR6C2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179695,OR6C2,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"salivary gland: 66.6667% (minimum 97%, Missing)",0.05,-0.303333,0.01,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179709,NLRP8,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"salivary gland: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179709,NLRP8,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"salivary gland: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179709,NLRP8,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"salivary gland: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179709,NLRP8,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.0333333,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179709,NLRP8,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.5612% (minimum 99%, Missing); basal ganglia: 98.9170% (minimum 99%, Missing); duodenum: 87.8205% (minimum 95%, Enhanced); heart muscle: 86.4353% (minimum 95%, Enhanced); hippocampal formation: 98.5612% (minimum 99%, Missing); hypothalamus: 98.9170% (minimum 99%, Missing); liver: 90.4290% (minimum 95%, Enhanced); midbrain: 98.2079% (minimum 99%, Missing); pancreas: 0.0997% (minimum 99%, Missing); pituitary gland: 96.8198% (minimum 99%, Missing); small intestine: 94.1581% (minimum 95%, Enhanced); spinal cord: 98.9170% (minimum 99%, Missing)",0.05,0.03,-0.989003,0,4,partial,27446.4,3.9,4.4,"pancreas: 27446.4 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179751,SYCN,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 0.0997% (minimum 75%, Missing)",0.35,0.3,-0.749003,0,4,partial,27446.4,3.9,4.4,"pancreas: 27446.4 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179751,SYCN,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 0.0997% (minimum 75%, Missing)",0.35,0.3,-0.749003,0,4,partial,27446.4,3.9,4.4,"pancreas: 27446.4 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179751,SYCN,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 0.0997% (minimum 75%, Missing)",0.35,0.3,-0.749003,0,4,partial,27446.4,3.9,4.4,"pancreas: 27446.4 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179751,SYCN,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 0.0997% (minimum 75%, Baseline (adaptation disabled))",0.211635,0.175399,-0.749003,0,4,partial,27446.4,3.9,4.4,"pancreas: 27446.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179751,SYCN,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 22.2222% (minimum 99%, Missing); basal ganglia: 22.5806% (minimum 99%, Missing); cerebellum: 24.5614% (minimum 98%, Approved); cerebral cortex: 22.5806% (minimum 99%, Missing); choroid plexus: 86.4198% (minimum 99%, Missing); colon: 93.3333% (minimum 95%, Approved); esophagus: 94.5946% (minimum 95%, Approved); heart muscle: 95.8904% (minimum 98%, Approved); hippocampal formation: 31.1111% (minimum 99%, Missing); hypothalamus: 37.8378% (minimum 99%, Missing); midbrain: 34.8259% (minimum 99%, Missing); pituitary gland: 82.3529% (minimum 99%, Missing); rectum: 93.3333% (minimum 95%, Approved); retina: 87.5000% (minimum 99%, Missing); salivary gland: 94.5946% (minimum 95%, Approved); skeletal muscle: 43.4783% (minimum 99%, Missing); small intestine: 97.2222% (minimum 98%, Approved); smooth muscle: 94.5946% (minimum 98%, Approved); spinal cord: 60.3448% (minimum 99%, Missing); stomach: 93.3333% (minimum 95%, Approved); thymus: 90.9091% (minimum 95%, Missing); urinary bladder: 60.3448% (minimum 95%, Approved)",-0.0409091,-0.346552,-0.767778,0,1,partial,24.5,4.6,0.7,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 2); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 4); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179796,LRRC3B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 22.2222% (minimum 75%, Missing); basal ganglia: 22.5806% (minimum 75%, Missing); cerebellum: 24.5614% (minimum 70%, Approved); cerebral cortex: 22.5806% (minimum 75%, Missing); hippocampal formation: 31.1111% (minimum 75%, Missing); hypothalamus: 37.8378% (minimum 75%, Missing); midbrain: 34.8259% (minimum 75%, Missing); skeletal muscle: 43.4783% (minimum 75%, Missing); spinal cord: 60.3448% (minimum 75%, Missing); urinary bladder: 60.3448% (minimum 65%, Approved)",0.259091,-0.0465517,-0.527778,0,1,partial,24.5,4.6,0.7,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 2); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 4); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179796,LRRC3B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 22.2222% (minimum 75%, Missing); basal ganglia: 22.5806% (minimum 75%, Missing); cerebellum: 24.5614% (minimum 70%, Approved); cerebral cortex: 22.5806% (minimum 75%, Missing); hippocampal formation: 31.1111% (minimum 75%, Missing); hypothalamus: 37.8378% (minimum 75%, Missing); midbrain: 34.8259% (minimum 75%, Missing); skeletal muscle: 43.4783% (minimum 75%, Missing); spinal cord: 60.3448% (minimum 75%, Missing); urinary bladder: 60.3448% (minimum 65%, Approved)",0.259091,-0.0465517,-0.527778,0,1,partial,24.5,4.6,0.7,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 2); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 4); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179796,LRRC3B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 22.2222% (minimum 75%, Missing); basal ganglia: 22.5806% (minimum 75%, Missing); cerebellum: 24.5614% (minimum 70%, Approved); cerebral cortex: 22.5806% (minimum 75%, Missing); hippocampal formation: 31.1111% (minimum 75%, Missing); hypothalamus: 37.8378% (minimum 75%, Missing); midbrain: 34.8259% (minimum 75%, Missing); skeletal muscle: 43.4783% (minimum 75%, Missing); spinal cord: 60.3448% (minimum 75%, Missing); urinary bladder: 60.3448% (minimum 65%, Approved)",0.259091,-0.0465517,-0.527778,0,1,partial,24.5,4.6,0.7,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 2); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 4); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179796,LRRC3B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 22.2222% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 22.5806% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 24.5614% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 22.5806% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 31.1111% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 37.8378% (minimum 75%, Baseline (adaptation disabled)); midbrain: 34.8259% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 43.4783% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 60.3448% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 60.3448% (minimum 70%, Baseline (adaptation disabled))",0.259091,-0.0965517,-0.527778,0,1,partial,24.5,4.6,0.7,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 1); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 3); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179796,LRRC3B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179817,MRGPRX4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179817,MRGPRX4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179817,MRGPRX4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179817,MRGPRX4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179817,MRGPRX4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 3.2895% (minimum 99%, Missing); choroid plexus: 93.7500% (minimum 99%, Missing); colon: 88.2353% (minimum 97%, Missing); duodenum: 88.2353% (minimum 99%, Missing); esophagus: 55.5556% (minimum 97%, Missing); hippocampal formation: 93.7500% (minimum 99%, Missing); hypothalamus: 93.7500% (minimum 99%, Missing); kidney: 62.5000% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 55.5556% (minimum 99%, Missing); lymph node: 93.7500% (minimum 97%, Missing); pancreas: 68.1818% (minimum 99%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 78.9474% (minimum 99%, Missing); salivary gland: 65.2174% (minimum 97%, Missing); skin: 62.5000% (minimum 95%, Missing); small intestine: 93.7500% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); thymus: 75.0000% (minimum 95%, Missing); thyroid gland: 34.0909% (minimum 95%, Missing); urinary bladder: 93.7500% (minimum 97%, Missing)",-0.609091,-0.414444,-0.957105,0,80,unavailable,44.1,1.2,2.9,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179869,ABCA13,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 3.2895% (minimum 75%, Missing); esophagus: 55.5556% (minimum 70%, Missing); kidney: 62.5000% (minimum 75%, Missing); lung: 55.5556% (minimum 75%, Missing); pancreas: 68.1818% (minimum 75%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); salivary gland: 65.2174% (minimum 70%, Missing); skin: 62.5000% (minimum 65%, Missing); thyroid gland: 34.0909% (minimum 65%, Missing)",-0.309091,-0.144444,-0.717105,0,80,unavailable,44.1,1.2,2.9,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179869,ABCA13,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 3.2895% (minimum 75%, Missing); esophagus: 55.5556% (minimum 70%, Missing); kidney: 62.5000% (minimum 75%, Missing); lung: 55.5556% (minimum 75%, Missing); pancreas: 68.1818% (minimum 75%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); salivary gland: 65.2174% (minimum 70%, Missing); skin: 62.5000% (minimum 65%, Missing); thyroid gland: 34.0909% (minimum 65%, Missing)",-0.309091,-0.144444,-0.717105,0,80,unavailable,44.1,1.2,2.9,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179869,ABCA13,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 3.2895% (minimum 75%, Missing); esophagus: 55.5556% (minimum 70%, Missing); kidney: 62.5000% (minimum 75%, Missing); lung: 55.5556% (minimum 75%, Missing); pancreas: 68.1818% (minimum 75%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); salivary gland: 65.2174% (minimum 70%, Missing); skin: 62.5000% (minimum 65%, Missing); thyroid gland: 34.0909% (minimum 65%, Missing)",-0.309091,-0.144444,-0.717105,0,80,unavailable,44.1,1.2,2.9,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179869,ABCA13,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 3.2895% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.5556% (minimum 70%, Baseline (adaptation disabled)); kidney: 62.5000% (minimum 75%, Baseline (adaptation disabled)); lung: 55.5556% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.1818% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.2174% (minimum 70%, Baseline (adaptation disabled)); skin: 62.5000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 34.0909% (minimum 65%, Baseline (adaptation disabled))",-0.309091,-0.144444,-0.717105,0,80,unavailable,44.1,1.2,2.9,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179869,ABCA13,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"colon: 91.6667% (minimum 97%, Missing); kidney: 84.6154% (minimum 99%, Missing); liver: 52.3810% (minimum 99%, Missing); lymph node: 84.6154% (minimum 97%, Missing); pancreas: 91.6667% (minimum 99%, Missing); parathyroid gland: 84.6154% (minimum 97%, Missing); rectum: 91.6667% (minimum 97%, Missing); spleen: 91.6667% (minimum 95%, Missing); stomach: 84.6154% (minimum 97%, Missing)",-0.0333333,-0.123846,-0.46619,0,80,unavailable,1,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179873,NLRP11,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 52.3810% (minimum 75%, Missing)",0.266667,0.146154,-0.22619,0,80,unavailable,1,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179873,NLRP11,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 52.3810% (minimum 75%, Missing)",0.266667,0.146154,-0.22619,0,80,unavailable,1,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179873,NLRP11,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 52.3810% (minimum 75%, Missing)",0.266667,0.146154,-0.22619,0,80,unavailable,1,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179873,NLRP11,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 52.3810% (minimum 75%, Baseline (adaptation disabled))",0.266667,0.146154,-0.22619,0,80,unavailable,1,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179873,NLRP11,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179919,OR10A7,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179919,OR10A7,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179919,OR10A7,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179919,OR10A7,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000179919,OR10A7,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 79.0698% (minimum 95%, Missing); adrenal gland: 60.7143% (minimum 99%, Missing); amygdala: 58.6207% (minimum 99%, Missing); basal ganglia: 58.6207% (minimum 99%, Missing); bone marrow: 35.7895% (minimum 99%, Missing); cerebellum: 72.3404% (minimum 99%, Missing); cerebral cortex: 53.1250% (minimum 99%, Missing); choroid plexus: 72.3404% (minimum 99%, Missing); colon: 69.3878% (minimum 97%, Missing); duodenum: 65.3846% (minimum 99%, Missing); esophagus: 69.3878% (minimum 97%, Missing); heart muscle: 68.0000% (minimum 99%, Missing); hippocampal formation: 55.7377% (minimum 99%, Missing); hypothalamus: 54.8387% (minimum 99%, Missing); kidney: 64.1509% (minimum 99%, Missing); liver: 45.9459% (minimum 99%, Missing); lung: 77.2727% (minimum 99%, Missing); lymph node: 79.0698% (minimum 97%, Missing); midbrain: 58.6207% (minimum 99%, Missing); pancreas: 62.9630% (minimum 99%, Missing); parathyroid gland: 77.2727% (minimum 97%, Missing); pituitary gland: 56.6667% (minimum 99%, Missing); rectum: 70.8333% (minimum 97%, Missing); retina: 87.1795% (minimum 99%, Missing); salivary gland: 64.1509% (minimum 97%, Missing); skeletal muscle: 50.7463% (minimum 99%, Missing); skin: 68.0000% (minimum 95%, Missing); small intestine: 77.2727% (minimum 99%, Missing); smooth muscle: 65.3846% (minimum 99%, Missing); spinal cord: 51.5152% (minimum 99%, Missing); spleen: 75.5556% (minimum 95%, Missing); stomach: 72.3404% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 59.6491% (minimum 95%, Missing); tongue: 79.0698% (minimum 97%, Missing); urinary bladder: 72.3404% (minimum 97%, Missing)",-0.353509,-0.328491,-0.632105,0,4,partial,6.1,1.9,2.3,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179988,PSTK,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.7143% (minimum 75%, Missing); amygdala: 58.6207% (minimum 75%, Missing); basal ganglia: 58.6207% (minimum 75%, Missing); bone marrow: 35.7895% (minimum 75%, Missing); cerebellum: 72.3404% (minimum 75%, Missing); cerebral cortex: 53.1250% (minimum 75%, Missing); choroid plexus: 72.3404% (minimum 75%, Missing); colon: 69.3878% (minimum 70%, Missing); duodenum: 65.3846% (minimum 75%, Missing); esophagus: 69.3878% (minimum 70%, Missing); heart muscle: 68.0000% (minimum 75%, Missing); hippocampal formation: 55.7377% (minimum 75%, Missing); hypothalamus: 54.8387% (minimum 75%, Missing); kidney: 64.1509% (minimum 75%, Missing); liver: 45.9459% (minimum 75%, Missing); midbrain: 58.6207% (minimum 75%, Missing); pancreas: 62.9630% (minimum 75%, Missing); pituitary gland: 56.6667% (minimum 75%, Missing); salivary gland: 64.1509% (minimum 70%, Missing); skeletal muscle: 50.7463% (minimum 75%, Missing); smooth muscle: 65.3846% (minimum 75%, Missing); spinal cord: 51.5152% (minimum 75%, Missing); thyroid gland: 59.6491% (minimum 65%, Missing)",-0.0535088,-0.0584906,-0.392105,0,4,partial,6.1,1.9,2.3,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179988,PSTK,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.7143% (minimum 75%, Missing); amygdala: 58.6207% (minimum 75%, Missing); basal ganglia: 58.6207% (minimum 75%, Missing); bone marrow: 35.7895% (minimum 75%, Missing); cerebellum: 72.3404% (minimum 75%, Missing); cerebral cortex: 53.1250% (minimum 75%, Missing); choroid plexus: 72.3404% (minimum 75%, Missing); colon: 69.3878% (minimum 70%, Missing); duodenum: 65.3846% (minimum 75%, Missing); esophagus: 69.3878% (minimum 70%, Missing); heart muscle: 68.0000% (minimum 75%, Missing); hippocampal formation: 55.7377% (minimum 75%, Missing); hypothalamus: 54.8387% (minimum 75%, Missing); kidney: 64.1509% (minimum 75%, Missing); liver: 45.9459% (minimum 75%, Missing); midbrain: 58.6207% (minimum 75%, Missing); pancreas: 62.9630% (minimum 75%, Missing); pituitary gland: 56.6667% (minimum 75%, Missing); salivary gland: 64.1509% (minimum 70%, Missing); skeletal muscle: 50.7463% (minimum 75%, Missing); smooth muscle: 65.3846% (minimum 75%, Missing); spinal cord: 51.5152% (minimum 75%, Missing); thyroid gland: 59.6491% (minimum 65%, Missing)",-0.0535088,-0.0584906,-0.392105,0,4,partial,6.1,1.9,2.3,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179988,PSTK,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.7143% (minimum 75%, Missing); amygdala: 58.6207% (minimum 75%, Missing); basal ganglia: 58.6207% (minimum 75%, Missing); bone marrow: 35.7895% (minimum 75%, Missing); cerebellum: 72.3404% (minimum 75%, Missing); cerebral cortex: 53.1250% (minimum 75%, Missing); choroid plexus: 72.3404% (minimum 75%, Missing); colon: 69.3878% (minimum 70%, Missing); duodenum: 65.3846% (minimum 75%, Missing); esophagus: 69.3878% (minimum 70%, Missing); heart muscle: 68.0000% (minimum 75%, Missing); hippocampal formation: 55.7377% (minimum 75%, Missing); hypothalamus: 54.8387% (minimum 75%, Missing); kidney: 64.1509% (minimum 75%, Missing); liver: 45.9459% (minimum 75%, Missing); midbrain: 58.6207% (minimum 75%, Missing); pancreas: 62.9630% (minimum 75%, Missing); pituitary gland: 56.6667% (minimum 75%, Missing); salivary gland: 64.1509% (minimum 70%, Missing); skeletal muscle: 50.7463% (minimum 75%, Missing); smooth muscle: 65.3846% (minimum 75%, Missing); spinal cord: 51.5152% (minimum 75%, Missing); thyroid gland: 59.6491% (minimum 65%, Missing)",-0.0535088,-0.0584906,-0.392105,0,4,partial,6.1,1.9,2.3,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179988,PSTK,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.7143% (minimum 75%, Baseline (adaptation disabled)); amygdala: 58.6207% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.6207% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 35.7895% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.3404% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.1250% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.3404% (minimum 75%, Baseline (adaptation disabled)); colon: 69.3878% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.3846% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.3878% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.7377% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 54.8387% (minimum 75%, Baseline (adaptation disabled)); kidney: 64.1509% (minimum 75%, Baseline (adaptation disabled)); liver: 45.9459% (minimum 75%, Baseline (adaptation disabled)); midbrain: 58.6207% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.9630% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 56.6667% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.1509% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 50.7463% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.3846% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 51.5152% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 59.6491% (minimum 65%, Baseline (adaptation disabled))",-0.0535088,-0.0584906,-0.392105,0,4,partial,6.1,1.9,2.3,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000179988,PSTK,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 66.6667% (minimum 99%, Missing); tongue: 66.6667% (minimum 97%, Missing)",0.05,-0.303333,-0.323333,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180016,OR1E1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 66.6667% (minimum 75%, Missing); tongue: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,-0.0833333,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180016,OR1E1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 66.6667% (minimum 75%, Missing); tongue: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,-0.0833333,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180016,OR1E1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 66.6667% (minimum 75%, Missing); tongue: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,-0.0833333,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180016,OR1E1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.0333333,-0.0833333,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180016,OR1E1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00640288,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180043,GARIN5B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.246403,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180043,GARIN5B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.246403,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180043,GARIN5B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.246403,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180043,GARIN5B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.246403,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180043,GARIN5B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.9345% (minimum 99%, Missing); retina: 97.9701% (minimum 99%, Missing)",0.0339056,0.0234995,-0.0206554,0,80,unavailable,2.9,0.6,1.5,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180083,WFDC11,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333906,0.293499,0.219345,0,80,unavailable,2.9,0.6,1.5,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180083,WFDC11,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333906,0.293499,0.219345,0,80,unavailable,2.9,0.6,1.5,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180083,WFDC11,grid_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333906,0.293499,0.219345,0,80,unavailable,2.9,0.6,1.5,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180083,WFDC11,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333906,0.293499,0.219345,0,80,unavailable,2.9,0.6,1.5,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180083,WFDC11,current_fixed,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 87.5000% (minimum 99%, Missing); retina: 87.5000% (minimum 99%, Missing); thymus: 87.5000% (minimum 95%, Missing)",-0.075,0.03,-0.115,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180090,OR3A1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.3,0.125,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180090,OR3A1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.3,0.125,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180090,OR3A1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.3,0.125,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180090,OR3A1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.225,0.3,0.125,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180090,OR3A1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.8553% (minimum 95%, Enhanced); amygdala: 96.0912% (minimum 99%, Missing); basal ganglia: 93.6508% (minimum 99%, Missing); cerebellum: 73.5661% (minimum 95%, Enhanced); choroid plexus: 90.7692% (minimum 99%, Missing); heart muscle: 94.8553% (minimum 95%, Enhanced); hippocampal formation: 94.8553% (minimum 99%, Missing); hypothalamus: 95.1613% (minimum 99%, Missing); kidney: 93.6508% (minimum 95%, Enhanced); liver: 92.1875% (minimum 95%, Enhanced); midbrain: 94.2492% (minimum 99%, Missing); pituitary gland: 91.0494% (minimum 99%, Missing); retina: 77.4278% (minimum 99%, Missing); skeletal muscle: 93.0599% (minimum 95%, Enhanced); spinal cord: 94.5513% (minimum 99%, Missing)",0.05,0.0266216,-0.215722,0,2,partial,10.6,3.9,5.5,"cerebellum: 10.6 nTPM (vital, limit 6); retina: 8.6 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180113,TDRD6,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342857,0.296622,0.0242782,0,2,partial,10.6,3.9,5.5,"cerebellum: 10.6 nTPM (vital, limit 6); retina: 8.6 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180113,TDRD6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342857,0.296622,0.0242782,0,2,partial,10.6,3.9,5.5,"cerebellum: 10.6 nTPM (vital, limit 6); retina: 8.6 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180113,TDRD6,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342857,0.296622,0.0242782,0,2,partial,10.6,3.9,5.5,"cerebellum: 10.6 nTPM (vital, limit 6); retina: 8.6 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180113,TDRD6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 73.5661% (minimum 75%, Baseline (adaptation disabled))",0.192857,0.183234,-0.0143392,0,2,partial,10.6,3.9,5.5,"cerebellum: 10.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); lymph node: 3.9 nTPM (protected, limit 3); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180113,TDRD6,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
True,compatible,,True,True,True,,0.0385057,0.03,0.01,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180116,REDIC1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338506,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180116,REDIC1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338506,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180116,REDIC1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338506,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180116,REDIC1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.338506,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180116,REDIC1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 87.1795% (minimum 99%, Missing); lung: 97.1429% (minimum 99%, Missing)",0.0214286,0.03,-0.118205,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180138,CSNK1A1L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.321429,0.3,0.121795,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180138,CSNK1A1L,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.321429,0.3,0.121795,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180138,CSNK1A1L,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.321429,0.3,0.121795,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180138,CSNK1A1L,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.321429,0.3,0.121795,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180138,CSNK1A1L,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.3776% (minimum 60%, Enhanced); adrenal gland: 38.3871% (minimum 99%, Missing); amygdala: 50.8547% (minimum 99%, Missing); basal ganglia: 56.1321% (minimum 99%, Missing); bone marrow: 53.6036% (minimum 99%, Missing); cerebellum: 58.6207% (minimum 99%, Missing); cerebral cortex: 44.5693% (minimum 99%, Missing); choroid plexus: 53.3632% (minimum 99%, Missing); colon: 34.5930% (minimum 97%, Missing); duodenum: 23.1969% (minimum 99%, Missing); esophagus: 39.9329% (minimum 97%, Missing); heart muscle: 37.7778% (minimum 99%, Missing); hippocampal formation: 49.7908% (minimum 99%, Missing); hypothalamus: 47.9839% (minimum 99%, Missing); kidney: 14.3201% (minimum 99%, Missing); liver: 16.0377% (minimum 99%, Missing); lung: 60.7143% (minimum 99%, Missing); lymph node: 59.5000% (minimum 80%, Enhanced); midbrain: 51.2931% (minimum 99%, Missing); pancreas: 43.1159% (minimum 99%, Missing); parathyroid gland: 46.8504% (minimum 97%, Missing); pituitary gland: 56.9378% (minimum 99%, Missing); rectum: 42.3488% (minimum 97%, Missing); retina: 61.9792% (minimum 99%, Missing); salivary gland: 54.0909% (minimum 97%, Missing); skeletal muscle: 28.9538% (minimum 95%, Enhanced); skin: 42.1986% (minimum 95%, Missing); small intestine: 28.5372% (minimum 99%, Missing); smooth muscle: 55.0926% (minimum 95%, Enhanced); spinal cord: 52.6549% (minimum 99%, Missing); spleen: 58.6207% (minimum 95%, Missing); stomach: 38.1410% (minimum 97%, Missing); thymus: 57.4879% (minimum 95%, Missing); thyroid gland: 57.7670% (minimum 95%, Missing); tongue: 30.7494% (minimum 97%, Missing); urinary bladder: 53.1250% (minimum 97%, Missing)",-0.528014,-0.662506,-0.846799,0,17,partial,71.2,26.8,16.3,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 6); tongue: 26.8 nTPM (protected, limit 2); colon: 22.5 nTPM (protected, limit 2); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 2); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 2); skin: 16.3 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 2); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 2); hypothalamus: 12.9 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 2); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); smooth muscle: 9.7 nTPM (vital, limit 6); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); thyroid gland: 8.7 nTPM (manageable, limit 5); spleen: 8.4 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / endothelial cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180185,FAHD1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.3776% (minimum 50%, Enhanced); adrenal gland: 38.3871% (minimum 75%, Missing); amygdala: 50.8547% (minimum 75%, Missing); basal ganglia: 56.1321% (minimum 75%, Missing); bone marrow: 53.6036% (minimum 75%, Missing); cerebellum: 58.6207% (minimum 75%, Missing); cerebral cortex: 44.5693% (minimum 75%, Missing); choroid plexus: 53.3632% (minimum 75%, Missing); colon: 34.5930% (minimum 70%, Missing); duodenum: 23.1969% (minimum 75%, Missing); esophagus: 39.9329% (minimum 70%, Missing); heart muscle: 37.7778% (minimum 75%, Missing); hippocampal formation: 49.7908% (minimum 75%, Missing); hypothalamus: 47.9839% (minimum 75%, Missing); kidney: 14.3201% (minimum 75%, Missing); liver: 16.0377% (minimum 75%, Missing); lung: 60.7143% (minimum 75%, Missing); midbrain: 51.2931% (minimum 75%, Missing); pancreas: 43.1159% (minimum 75%, Missing); parathyroid gland: 46.8504% (minimum 70%, Missing); pituitary gland: 56.9378% (minimum 75%, Missing); rectum: 42.3488% (minimum 70%, Missing); retina: 61.9792% (minimum 75%, Missing); salivary gland: 54.0909% (minimum 70%, Missing); skeletal muscle: 28.9538% (minimum 60%, Enhanced); skin: 42.1986% (minimum 65%, Missing); small intestine: 28.5372% (minimum 75%, Missing); smooth muscle: 55.0926% (minimum 60%, Enhanced); spinal cord: 52.6549% (minimum 75%, Missing); spleen: 58.6207% (minimum 65%, Missing); stomach: 38.1410% (minimum 70%, Missing); thymus: 57.4879% (minimum 65%, Missing); thyroid gland: 57.7670% (minimum 65%, Missing); tongue: 30.7494% (minimum 70%, Missing); urinary bladder: 53.1250% (minimum 70%, Missing)",-0.228014,-0.392506,-0.606799,0,17,partial,71.2,26.8,16.3,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 6); tongue: 26.8 nTPM (protected, limit 2); colon: 22.5 nTPM (protected, limit 2); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 2); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 2); skin: 16.3 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 2); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 2); hypothalamus: 12.9 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 2); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); smooth muscle: 9.7 nTPM (vital, limit 6); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); thyroid gland: 8.7 nTPM (manageable, limit 5); spleen: 8.4 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / endothelial cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180185,FAHD1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.3776% (minimum 50%, Enhanced); adrenal gland: 38.3871% (minimum 75%, Missing); amygdala: 50.8547% (minimum 75%, Missing); basal ganglia: 56.1321% (minimum 75%, Missing); bone marrow: 53.6036% (minimum 75%, Missing); cerebellum: 58.6207% (minimum 75%, Missing); cerebral cortex: 44.5693% (minimum 75%, Missing); choroid plexus: 53.3632% (minimum 75%, Missing); colon: 34.5930% (minimum 70%, Missing); duodenum: 23.1969% (minimum 75%, Missing); esophagus: 39.9329% (minimum 70%, Missing); heart muscle: 37.7778% (minimum 75%, Missing); hippocampal formation: 49.7908% (minimum 75%, Missing); hypothalamus: 47.9839% (minimum 75%, Missing); kidney: 14.3201% (minimum 75%, Missing); liver: 16.0377% (minimum 75%, Missing); lung: 60.7143% (minimum 75%, Missing); midbrain: 51.2931% (minimum 75%, Missing); pancreas: 43.1159% (minimum 75%, Missing); parathyroid gland: 46.8504% (minimum 70%, Missing); pituitary gland: 56.9378% (minimum 75%, Missing); rectum: 42.3488% (minimum 70%, Missing); retina: 61.9792% (minimum 75%, Missing); salivary gland: 54.0909% (minimum 70%, Missing); skeletal muscle: 28.9538% (minimum 60%, Enhanced); skin: 42.1986% (minimum 65%, Missing); small intestine: 28.5372% (minimum 75%, Missing); smooth muscle: 55.0926% (minimum 60%, Enhanced); spinal cord: 52.6549% (minimum 75%, Missing); spleen: 58.6207% (minimum 65%, Missing); stomach: 38.1410% (minimum 70%, Missing); thymus: 57.4879% (minimum 65%, Missing); thyroid gland: 57.7670% (minimum 65%, Missing); tongue: 30.7494% (minimum 70%, Missing); urinary bladder: 53.1250% (minimum 70%, Missing)",-0.228014,-0.392506,-0.606799,0,17,partial,71.2,26.8,16.3,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 6); tongue: 26.8 nTPM (protected, limit 3); colon: 22.5 nTPM (protected, limit 3); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 3); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 3); skin: 16.3 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 3); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 3); hypothalamus: 12.9 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 3); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); smooth muscle: 9.7 nTPM (vital, limit 6); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); thyroid gland: 8.7 nTPM (manageable, limit 5); spleen: 8.4 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / endothelial cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180185,FAHD1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.3776% (minimum 50%, Enhanced); adrenal gland: 38.3871% (minimum 75%, Missing); amygdala: 50.8547% (minimum 75%, Missing); basal ganglia: 56.1321% (minimum 75%, Missing); bone marrow: 53.6036% (minimum 75%, Missing); cerebellum: 58.6207% (minimum 75%, Missing); cerebral cortex: 44.5693% (minimum 75%, Missing); choroid plexus: 53.3632% (minimum 75%, Missing); colon: 34.5930% (minimum 70%, Missing); duodenum: 23.1969% (minimum 75%, Missing); esophagus: 39.9329% (minimum 70%, Missing); heart muscle: 37.7778% (minimum 75%, Missing); hippocampal formation: 49.7908% (minimum 75%, Missing); hypothalamus: 47.9839% (minimum 75%, Missing); kidney: 14.3201% (minimum 75%, Missing); liver: 16.0377% (minimum 75%, Missing); lung: 60.7143% (minimum 75%, Missing); midbrain: 51.2931% (minimum 75%, Missing); pancreas: 43.1159% (minimum 75%, Missing); parathyroid gland: 46.8504% (minimum 70%, Missing); pituitary gland: 56.9378% (minimum 75%, Missing); rectum: 42.3488% (minimum 70%, Missing); retina: 61.9792% (minimum 75%, Missing); salivary gland: 54.0909% (minimum 70%, Missing); skeletal muscle: 28.9538% (minimum 60%, Enhanced); skin: 42.1986% (minimum 65%, Missing); small intestine: 28.5372% (minimum 75%, Missing); smooth muscle: 55.0926% (minimum 60%, Enhanced); spinal cord: 52.6549% (minimum 75%, Missing); spleen: 58.6207% (minimum 65%, Missing); stomach: 38.1410% (minimum 70%, Missing); thymus: 57.4879% (minimum 65%, Missing); thyroid gland: 57.7670% (minimum 65%, Missing); tongue: 30.7494% (minimum 70%, Missing); urinary bladder: 53.1250% (minimum 70%, Missing)",-0.228014,-0.392506,-0.606799,0,17,partial,71.2,26.8,16.3,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 6); tongue: 26.8 nTPM (protected, limit 3); colon: 22.5 nTPM (protected, limit 3); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 3); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 3); skin: 16.3 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 3); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 3); hypothalamus: 12.9 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 3); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); smooth muscle: 9.7 nTPM (vital, limit 6); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); thyroid gland: 8.7 nTPM (manageable, limit 5); spleen: 8.4 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / endothelial cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180185,FAHD1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.3776% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 38.3871% (minimum 75%, Baseline (adaptation disabled)); amygdala: 50.8547% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.1321% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 53.6036% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 58.6207% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 44.5693% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 53.3632% (minimum 75%, Baseline (adaptation disabled)); colon: 34.5930% (minimum 70%, Baseline (adaptation disabled)); duodenum: 23.1969% (minimum 75%, Baseline (adaptation disabled)); esophagus: 39.9329% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 37.7778% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 49.7908% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 47.9839% (minimum 75%, Baseline (adaptation disabled)); kidney: 14.3201% (minimum 75%, Baseline (adaptation disabled)); liver: 16.0377% (minimum 75%, Baseline (adaptation disabled)); lung: 60.7143% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.5000% (minimum 70%, Baseline (adaptation disabled)); midbrain: 51.2931% (minimum 75%, Baseline (adaptation disabled)); pancreas: 43.1159% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 46.8504% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 56.9378% (minimum 75%, Baseline (adaptation disabled)); rectum: 42.3488% (minimum 70%, Baseline (adaptation disabled)); retina: 61.9792% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 54.0909% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 28.9538% (minimum 75%, Baseline (adaptation disabled)); skin: 42.1986% (minimum 65%, Baseline (adaptation disabled)); small intestine: 28.5372% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.0926% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 52.6549% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.6207% (minimum 65%, Baseline (adaptation disabled)); stomach: 38.1410% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.4879% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.7670% (minimum 65%, Baseline (adaptation disabled)); tongue: 30.7494% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 53.1250% (minimum 70%, Baseline (adaptation disabled))",-0.228014,-0.392506,-0.606799,0,17,partial,71.2,26.8,16.3,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 26.8 nTPM (protected, limit 3); colon: 22.5 nTPM (protected, limit 3); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 3); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 3); skin: 16.3 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 3); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 3); hypothalamus: 12.9 nTPM (vital, limit 1); adipose tissue: 12.2 nTPM (manageable, limit 5); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 3); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); thyroid gland: 8.7 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 3); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / endothelial cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180185,FAHD1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180205,WFDC9,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180205,WFDC9,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180205,WFDC9,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180205,WFDC9,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180205,WFDC9,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00695122,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180219,GARIN6,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246951,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180219,GARIN6,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246951,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180219,GARIN6,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246951,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180219,GARIN6,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246951,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180219,GARIN6,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 20.0000% (minimum 99%, Missing); bone marrow: 20.0000% (minimum 99%, Missing); choroid plexus: 50.0000% (minimum 99%, Missing); hypothalamus: 33.3333% (minimum 99%, Missing)",0.05,0.03,-0.79,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180269,GPR139,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 20.0000% (minimum 75%, Missing); bone marrow: 20.0000% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); hypothalamus: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.55,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180269,GPR139,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 20.0000% (minimum 75%, Missing); bone marrow: 20.0000% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); hypothalamus: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.55,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180269,GPR139,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 20.0000% (minimum 75%, Missing); bone marrow: 20.0000% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); hypothalamus: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.55,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180269,GPR139,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 20.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 20.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 33.3333% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.55,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180269,GPR139,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.0296436,0.00964362,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180305,WFDC10A,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299644,0.249644,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180305,WFDC10A,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299644,0.249644,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180305,WFDC10A,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299644,0.249644,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180305,WFDC10A,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299644,0.249644,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180305,WFDC10A,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2979% (minimum 99%, Missing); basal ganglia: 97.6744% (minimum 99%, Missing); cerebellum: 93.3333% (minimum 95%, Enhanced); hippocampal formation: 97.6744% (minimum 99%, Missing); hypothalamus: 97.8814% (minimum 99%, Missing); midbrain: 98.2979% (minimum 99%, Missing); retina: 96.8553% (minimum 99%, Missing); spinal cord: 98.5075% (minimum 99%, Missing)",0.05,0.03,-0.0214465,0,1,partial,3.3,0.4,0.8,"retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180336,MEIOC,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.218553,0,1,partial,3.3,0.4,0.8,"retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180336,MEIOC,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.218553,0,1,partial,3.3,0.4,0.8,"retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180336,MEIOC,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.218553,0,1,partial,3.3,0.4,0.8,"retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180336,MEIOC,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.332979,0.291416,0.183333,0,1,partial,3.3,0.4,0.8,"cerebellum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180336,MEIOC,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.4015% (minimum 90%, Approved); adrenal gland: 82.3944% (minimum 98%, Approved); amygdala: 87.3134% (minimum 99%, Missing); basal ganglia: 84.1727% (minimum 99%, Missing); bone marrow: 68.4211% (minimum 98%, Approved); cerebellum: 92.8571% (minimum 98%, Approved); cerebral cortex: 80.6897% (minimum 98%, Approved); choroid plexus: 88.6364% (minimum 99%, Missing); colon: 80.1370% (minimum 95%, Approved); duodenum: 81.8182% (minimum 98%, Approved); esophagus: 84.1727% (minimum 95%, Approved); heart muscle: 82.9787% (minimum 98%, Approved); hippocampal formation: 84.7826% (minimum 99%, Missing); hypothalamus: 86.6667% (minimum 99%, Missing); kidney: 80.6897% (minimum 98%, Approved); liver: 79.0541% (minimum 98%, Approved); lung: 84.7826% (minimum 98%, Approved); lymph node: 78.0000% (minimum 97%, Missing); midbrain: 82.9787% (minimum 99%, Missing); pancreas: 83.5714% (minimum 98%, Approved); parathyroid gland: 84.7826% (minimum 95%, Approved); pituitary gland: 82.9787% (minimum 99%, Missing); rectum: 78.0000% (minimum 95%, Approved); retina: 81.8182% (minimum 99%, Missing); salivary gland: 81.2500% (minimum 95%, Approved); skeletal muscle: 82.3944% (minimum 98%, Approved); skin: 79.0541% (minimum 90%, Approved); small intestine: 81.2500% (minimum 98%, Approved); smooth muscle: 80.1370% (minimum 98%, Approved); spinal cord: 80.6897% (minimum 99%, Missing); spleen: 82.9787% (minimum 90%, Approved); stomach: 75.0000% (minimum 97%, Missing); thymus: 74.0506% (minimum 95%, Missing); thyroid gland: 81.8182% (minimum 90%, Approved); tongue: 86.0294% (minimum 97%, Missing); urinary bladder: 82.3944% (minimum 95%, Approved)",-0.209494,-0.22,-0.295789,0,4,partial,5.4,3.9,4.1,"bone marrow: 5.4 nTPM (vital, limit 2); stomach: 3.9 nTPM (protected, limit 2); lymph node: 3.3 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 2); small intestine: 2.7 nTPM (vital, limit 2); retina: 2.6 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 2); adrenal gland: 2.5 nTPM (vital, limit 2); midbrain: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 2); pancreas: 2.3 nTPM (vital, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180423,HARBI1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.4211% (minimum 70%, Approved)",0.0905063,0.05,-0.0157895,0,4,partial,5.4,3.9,4.1,"bone marrow: 5.4 nTPM (vital, limit 2); stomach: 3.9 nTPM (protected, limit 2); lymph node: 3.3 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 2); small intestine: 2.7 nTPM (vital, limit 2); retina: 2.6 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 2); adrenal gland: 2.5 nTPM (vital, limit 2); midbrain: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 2); pancreas: 2.3 nTPM (vital, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180423,HARBI1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.4211% (minimum 70%, Approved)",0.0905063,0.05,-0.0157895,0,4,partial,5.4,3.9,4.1,"bone marrow: 5.4 nTPM (vital, limit 2); stomach: 3.9 nTPM (protected, limit 3); lymph node: 3.3 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 2); small intestine: 2.7 nTPM (vital, limit 2); retina: 2.6 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 2); adrenal gland: 2.5 nTPM (vital, limit 2); midbrain: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 2); pancreas: 2.3 nTPM (vital, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180423,HARBI1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.4211% (minimum 70%, Approved)",0.0905063,0.05,-0.0157895,0,4,partial,5.4,3.9,4.1,"bone marrow: 5.4 nTPM (vital, limit 2); stomach: 3.9 nTPM (protected, limit 3); lymph node: 3.3 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 2); small intestine: 2.7 nTPM (vital, limit 2); retina: 2.6 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 2); adrenal gland: 2.5 nTPM (vital, limit 2); midbrain: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 2); pancreas: 2.3 nTPM (vital, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180423,HARBI1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.4211% (minimum 75%, Baseline (adaptation disabled))",0.0905063,0.05,-0.0657895,0,4,partial,5.4,3.9,4.1,"bone marrow: 5.4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 3); lymph node: 3.3 nTPM (protected, limit 3); rectum: 3.3 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180423,HARBI1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0493553,0.03,0.007426,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180424,DEFB123,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349355,0.3,0.247426,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180424,DEFB123,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349355,0.3,0.247426,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180424,DEFB123,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349355,0.3,0.247426,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180424,DEFB123,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349355,0.3,0.247426,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180424,DEFB123,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.9161% (minimum 99%, Missing); amygdala: 92.0300% (minimum 99%, Missing); basal ganglia: 90.9152% (minimum 99%, Missing); bone marrow: 97.3343% (minimum 99%, Missing); cerebellum: 94.6078% (minimum 99%, Missing); cerebral cortex: 93.1724% (minimum 99%, Missing); choroid plexus: 95.0070% (minimum 99%, Missing); colon: 95.2750% (minimum 97%, Missing); duodenum: 94.8070% (minimum 99%, Missing); esophagus: 96.9849% (minimum 97%, Missing); heart muscle: 93.7543% (minimum 99%, Missing); hippocampal formation: 91.6554% (minimum 99%, Missing); hypothalamus: 91.3455% (minimum 99%, Missing); kidney: 90.9764% (minimum 99%, Missing); liver: 86.2157% (minimum 99%, Missing); lung: 95.8836% (minimum 99%, Missing); lymph node: 95.4096% (minimum 97%, Missing); midbrain: 92.2814% (minimum 99%, Missing); pancreas: 94.0808% (minimum 99%, Missing); parathyroid gland: 94.0153% (minimum 97%, Missing); pituitary gland: 91.1606% (minimum 99%, Missing); rectum: 95.7477% (minimum 97%, Missing); retina: 89.7674% (minimum 99%, Missing); salivary gland: 93.4302% (minimum 97%, Missing); skeletal muscle: 90.3075% (minimum 99%, Missing); skin: 93.6893% (minimum 95%, Missing); small intestine: 94.8736% (minimum 99%, Missing); smooth muscle: 97.9695% (minimum 99%, Missing); spinal cord: 92.3445% (minimum 99%, Missing); spleen: 93.6893% (minimum 95%, Missing); stomach: 95.0070% (minimum 97%, Missing); thymus: 93.9499% (minimum 95%, Missing); thyroid gland: 91.7799% (minimum 95%, Missing); tongue: 90.2472% (minimum 97%, Missing); urinary bladder: 96.8459% (minimum 97%, Missing)",-0.0322011,-0.0675284,-0.127843,0,80,unavailable,21.6,14.6,12.1,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 2); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); salivary gland: 9.5 nTPM (protected, limit 2); spleen: 9.1 nTPM (manageable, limit 5); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); thymus: 8.7 nTPM (manageable, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 2); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); lymph node: 6.5 nTPM (protected, limit 2); rectum: 6 nTPM (protected, limit 2); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (manageable, limit 5); urinary bladder: 4.4 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180425,C11orf71,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.267799,0.202472,0.112157,0,80,unavailable,21.6,14.6,12.1,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 2); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); salivary gland: 9.5 nTPM (protected, limit 2); spleen: 9.1 nTPM (manageable, limit 5); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); thymus: 8.7 nTPM (manageable, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 2); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); lymph node: 6.5 nTPM (protected, limit 2); rectum: 6 nTPM (protected, limit 2); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (manageable, limit 5); urinary bladder: 4.4 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180425,C11orf71,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.267799,0.202472,0.112157,0,80,unavailable,21.6,14.6,12.1,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 3); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); salivary gland: 9.5 nTPM (protected, limit 3); spleen: 9.1 nTPM (manageable, limit 5); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); thymus: 8.7 nTPM (manageable, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 3); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); lymph node: 6.5 nTPM (protected, limit 3); rectum: 6 nTPM (protected, limit 3); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (manageable, limit 5); urinary bladder: 4.4 nTPM (protected, limit 3); esophagus: 4.2 nTPM (protected, limit 3); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180425,C11orf71,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.267799,0.202472,0.112157,0,80,unavailable,21.6,14.6,12.1,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 3); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); salivary gland: 9.5 nTPM (protected, limit 3); spleen: 9.1 nTPM (manageable, limit 5); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); thymus: 8.7 nTPM (manageable, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 3); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); lymph node: 6.5 nTPM (protected, limit 3); rectum: 6 nTPM (protected, limit 3); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (manageable, limit 5); urinary bladder: 4.4 nTPM (protected, limit 3); esophagus: 4.2 nTPM (protected, limit 3); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180425,C11orf71,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.267799,0.202472,0.112157,0,80,unavailable,21.6,14.6,12.1,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 3); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); salivary gland: 9.5 nTPM (protected, limit 3); spleen: 9.1 nTPM (manageable, limit 5); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); thymus: 8.7 nTPM (manageable, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 3); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); lymph node: 6.5 nTPM (protected, limit 3); rectum: 6 nTPM (protected, limit 3); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (manageable, limit 5); urinary bladder: 4.4 nTPM (protected, limit 3); esophagus: 4.2 nTPM (protected, limit 3); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180425,C11orf71,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.9006% (minimum 95%, Missing); adrenal gland: 65.8879% (minimum 99%, Missing); amygdala: 76.2162% (minimum 99%, Missing); basal ganglia: 78.7709% (minimum 99%, Missing); bone marrow: 62.6667% (minimum 99%, Missing); cerebellum: 73.0570% (minimum 99%, Missing); cerebral cortex: 71.9388% (minimum 99%, Missing); choroid plexus: 71.2121% (minimum 99%, Missing); colon: 81.0345% (minimum 97%, Missing); duodenum: 87.0370% (minimum 99%, Missing); esophagus: 77.9006% (minimum 97%, Missing); heart muscle: 77.9006% (minimum 99%, Missing); hippocampal formation: 74.2105% (minimum 99%, Missing); hypothalamus: 74.6032% (minimum 99%, Missing); kidney: 66.5094% (minimum 99%, Missing); liver: 80.1136% (minimum 99%, Missing); lung: 78.7709% (minimum 99%, Missing); lymph node: 72.3077% (minimum 97%, Missing); midbrain: 76.2162% (minimum 99%, Missing); pancreas: 81.9767% (minimum 99%, Missing); parathyroid gland: 54.8638% (minimum 97%, Missing); pituitary gland: 62.1145% (minimum 99%, Missing); rectum: 80.5714% (minimum 97%, Missing); retina: 33.4917% (minimum 99%, Missing); salivary gland: 81.5029% (minimum 97%, Missing); skeletal muscle: 77.9006% (minimum 99%, Missing); skin: 62.9464% (minimum 95%, Missing); small intestine: 83.4320% (minimum 99%, Missing); smooth muscle: 75.4011% (minimum 99%, Missing); spinal cord: 72.3077% (minimum 99%, Missing); spleen: 72.6804% (minimum 95%, Missing); stomach: 78.7709% (minimum 97%, Missing); thymus: 70.1493% (minimum 95%, Missing); thyroid gland: 15.7895% (minimum 95%, Missing); tongue: 79.2135% (minimum 97%, Missing); urinary bladder: 76.6304% (minimum 97%, Missing)",-0.792105,-0.421362,-0.655083,0,80,unavailable,28,11.6,75.2,"thyroid gland: 75.2 nTPM (manageable, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 2); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); thymus: 6 nTPM (manageable, limit 5); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); spinal cord: 5.4 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180479,ZNF571,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.8879% (minimum 75%, Missing); bone marrow: 62.6667% (minimum 75%, Missing); cerebellum: 73.0570% (minimum 75%, Missing); cerebral cortex: 71.9388% (minimum 75%, Missing); choroid plexus: 71.2121% (minimum 75%, Missing); hippocampal formation: 74.2105% (minimum 75%, Missing); hypothalamus: 74.6032% (minimum 75%, Missing); kidney: 66.5094% (minimum 75%, Missing); parathyroid gland: 54.8638% (minimum 70%, Missing); pituitary gland: 62.1145% (minimum 75%, Missing); retina: 33.4917% (minimum 75%, Missing); skin: 62.9464% (minimum 65%, Missing); spinal cord: 72.3077% (minimum 75%, Missing); thyroid gland: 15.7895% (minimum 65%, Missing)",-0.492105,-0.151362,-0.415083,0,80,unavailable,28,11.6,75.2,"thyroid gland: 75.2 nTPM (manageable, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 2); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); thymus: 6 nTPM (manageable, limit 5); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); spinal cord: 5.4 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180479,ZNF571,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.8879% (minimum 75%, Missing); bone marrow: 62.6667% (minimum 75%, Missing); cerebellum: 73.0570% (minimum 75%, Missing); cerebral cortex: 71.9388% (minimum 75%, Missing); choroid plexus: 71.2121% (minimum 75%, Missing); hippocampal formation: 74.2105% (minimum 75%, Missing); hypothalamus: 74.6032% (minimum 75%, Missing); kidney: 66.5094% (minimum 75%, Missing); parathyroid gland: 54.8638% (minimum 70%, Missing); pituitary gland: 62.1145% (minimum 75%, Missing); retina: 33.4917% (minimum 75%, Missing); skin: 62.9464% (minimum 65%, Missing); spinal cord: 72.3077% (minimum 75%, Missing); thyroid gland: 15.7895% (minimum 65%, Missing)",-0.492105,-0.151362,-0.415083,0,80,unavailable,28,11.6,75.2,"thyroid gland: 75.2 nTPM (manageable, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 3); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); thymus: 6 nTPM (manageable, limit 5); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); spinal cord: 5.4 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180479,ZNF571,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.8879% (minimum 75%, Missing); bone marrow: 62.6667% (minimum 75%, Missing); cerebellum: 73.0570% (minimum 75%, Missing); cerebral cortex: 71.9388% (minimum 75%, Missing); choroid plexus: 71.2121% (minimum 75%, Missing); hippocampal formation: 74.2105% (minimum 75%, Missing); hypothalamus: 74.6032% (minimum 75%, Missing); kidney: 66.5094% (minimum 75%, Missing); parathyroid gland: 54.8638% (minimum 70%, Missing); pituitary gland: 62.1145% (minimum 75%, Missing); retina: 33.4917% (minimum 75%, Missing); skin: 62.9464% (minimum 65%, Missing); spinal cord: 72.3077% (minimum 75%, Missing); thyroid gland: 15.7895% (minimum 65%, Missing)",-0.492105,-0.151362,-0.415083,0,80,unavailable,28,11.6,75.2,"thyroid gland: 75.2 nTPM (manageable, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 3); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); thymus: 6 nTPM (manageable, limit 5); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); spinal cord: 5.4 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180479,ZNF571,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.8879% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 62.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.0570% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 71.9388% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 71.2121% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.2105% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.6032% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.5094% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 54.8638% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.1145% (minimum 75%, Baseline (adaptation disabled)); retina: 33.4917% (minimum 75%, Baseline (adaptation disabled)); skin: 62.9464% (minimum 65%, Baseline (adaptation disabled)); spinal cord: 72.3077% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 15.7895% (minimum 65%, Baseline (adaptation disabled))",-0.492105,-0.151362,-0.415083,0,80,unavailable,28,11.6,75.2,"thyroid gland: 75.2 nTPM (manageable, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 3); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); thymus: 6 nTPM (manageable, limit 5); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); spinal cord: 5.4 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180479,ZNF571,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.7699% (minimum 95%, Enhanced); amygdala: 92.0732% (minimum 99%, Missing); basal ganglia: 92.0732% (minimum 99%, Missing); cerebral cortex: 93.4021% (minimum 95%, Enhanced); choroid plexus: 96.1783% (minimum 99%, Missing); hippocampal formation: 92.4490% (minimum 99%, Missing); hypothalamus: 93.0185% (minimum 99%, Missing); kidney: 95.9746% (minimum 99%, Missing); midbrain: 89.5257% (minimum 99%, Missing); pancreas: 94.5720% (minimum 95%, Enhanced); pituitary gland: 94.7699% (minimum 99%, Missing); retina: 94.3750% (minimum 99%, Missing); spinal cord: 87.6209% (minimum 99%, Missing); tongue: 96.7949% (minimum 97%, Missing)",0.022103,-0.00205128,-0.113791,0,3,partial,6.4,3.9,2.3,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180481,GLIPR1L2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.322103,0.267949,0.126209,0,3,partial,6.4,3.9,2.3,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180481,GLIPR1L2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.322103,0.267949,0.126209,0,3,partial,6.4,3.9,2.3,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180481,GLIPR1L2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.322103,0.267949,0.126209,0,3,partial,6.4,3.9,2.3,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180481,GLIPR1L2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.301681,0.220732,0.126209,0,3,partial,6.4,3.9,2.3,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180481,GLIPR1L2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 92.5402% (minimum 99%, Missing)",0.05,0.03,-0.0645981,0,3,partial,150.8,0.1,0.1,"retina: 150.8 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180483,DEFB119,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.175402,0,3,partial,150.8,0.1,0.1,"retina: 150.8 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180483,DEFB119,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.175402,0,3,partial,150.8,0.1,0.1,"retina: 150.8 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180483,DEFB119,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.175402,0,3,partial,150.8,0.1,0.1,"retina: 150.8 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180483,DEFB119,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349947,0.299947,0.175402,0,3,partial,150.8,0.1,0.1,"retina: 150.8 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180483,DEFB119,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 84.2105% (minimum 95%, Missing); adrenal gland: 76.1905% (minimum 99%, Missing); amygdala: 72.7273% (minimum 99%, Missing); basal ganglia: 64.0000% (minimum 99%, Missing); bone marrow: 72.7273% (minimum 99%, Missing); cerebellum: 64.0000% (minimum 99%, Missing); cerebral cortex: 61.5385% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 72.7273% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); esophagus: 88.8889% (minimum 97%, Missing); heart muscle: 57.1429% (minimum 99%, Missing); hippocampal formation: 72.7273% (minimum 99%, Missing); hypothalamus: 76.1905% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); liver: 53.3333% (minimum 99%, Missing); lung: 84.2105% (minimum 99%, Missing); lymph node: 94.1176% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 76.1905% (minimum 99%, Missing); parathyroid gland: 61.5385% (minimum 97%, Missing); pituitary gland: 76.1905% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 51.6129% (minimum 99%, Missing); salivary gland: 76.1905% (minimum 97%, Missing); skeletal muscle: 94.1176% (minimum 99%, Missing); skin: 61.5385% (minimum 95%, Missing); small intestine: 94.1176% (minimum 99%, Missing); smooth muscle: 84.2105% (minimum 99%, Missing); spinal cord: 84.2105% (minimum 99%, Missing); spleen: 94.1176% (minimum 95%, Missing); stomach: 88.8889% (minimum 97%, Missing); thymus: 88.8889% (minimum 95%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); tongue: 88.8889% (minimum 97%, Missing); urinary bladder: 84.2105% (minimum 97%, Missing)",-0.378571,-0.354615,-0.473871,0,80,unavailable,1.5,1,1.2,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180592,SKIDA1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 64.0000% (minimum 75%, Missing); bone marrow: 72.7273% (minimum 75%, Missing); cerebellum: 64.0000% (minimum 75%, Missing); cerebral cortex: 61.5385% (minimum 75%, Missing); heart muscle: 57.1429% (minimum 75%, Missing); hippocampal formation: 72.7273% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 53.3333% (minimum 75%, Missing); parathyroid gland: 61.5385% (minimum 70%, Missing); retina: 51.6129% (minimum 75%, Missing); skin: 61.5385% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.0846154,-0.233871,0,80,unavailable,1.5,1,1.2,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180592,SKIDA1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 64.0000% (minimum 75%, Missing); bone marrow: 72.7273% (minimum 75%, Missing); cerebellum: 64.0000% (minimum 75%, Missing); cerebral cortex: 61.5385% (minimum 75%, Missing); heart muscle: 57.1429% (minimum 75%, Missing); hippocampal formation: 72.7273% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 53.3333% (minimum 75%, Missing); parathyroid gland: 61.5385% (minimum 70%, Missing); retina: 51.6129% (minimum 75%, Missing); skin: 61.5385% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.0846154,-0.233871,0,80,unavailable,1.5,1,1.2,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180592,SKIDA1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 64.0000% (minimum 75%, Missing); bone marrow: 72.7273% (minimum 75%, Missing); cerebellum: 64.0000% (minimum 75%, Missing); cerebral cortex: 61.5385% (minimum 75%, Missing); heart muscle: 57.1429% (minimum 75%, Missing); hippocampal formation: 72.7273% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 53.3333% (minimum 75%, Missing); parathyroid gland: 61.5385% (minimum 70%, Missing); retina: 51.6129% (minimum 75%, Missing); skin: 61.5385% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.0846154,-0.233871,0,80,unavailable,1.5,1,1.2,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180592,SKIDA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.7273% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 72.7273% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.5385% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 57.1429% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.7273% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 75%, Baseline (adaptation disabled)); liver: 53.3333% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.5385% (minimum 70%, Baseline (adaptation disabled)); retina: 51.6129% (minimum 75%, Baseline (adaptation disabled)); skin: 61.5385% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 65%, Baseline (adaptation disabled))",-0.0785714,-0.0846154,-0.233871,0,80,unavailable,1.5,1,1.2,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180592,SKIDA1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6842% (minimum 90%, Approved); adrenal gland: 42.0330% (minimum 98%, Approved); amygdala: 50.3289% (minimum 99%, Missing); basal ganglia: 53.6842% (minimum 99%, Missing); bone marrow: 72.8571% (minimum 98%, Approved); cerebellum: 61.2000% (minimum 99%, Missing); cerebral cortex: 45.9459% (minimum 99%, Missing); choroid plexus: 76.5000% (minimum 99%, Missing); colon: 50.8306% (minimum 95%, Approved); duodenum: 47.2222% (minimum 99%, Missing); esophagus: 55.2347% (minimum 97%, Missing); heart muscle: 35.9155% (minimum 98%, Approved); hippocampal formation: 54.8387% (minimum 99%, Missing); hypothalamus: 50.6623% (minimum 99%, Missing); kidney: 40.3694% (minimum 99%, Missing); liver: 37.5921% (minimum 99%, Missing); lung: 54.6429% (minimum 98%, Approved); lymph node: 48.2650% (minimum 95%, Approved); midbrain: 49.1961% (minimum 99%, Missing); pancreas: 49.5146% (minimum 99%, Missing); parathyroid gland: 44.3478% (minimum 95%, Approved); pituitary gland: 68.6099% (minimum 99%, Missing); rectum: 52.7586% (minimum 95%, Approved); retina: 49.3548% (minimum 99%, Missing); salivary gland: 47.2222% (minimum 95%, Approved); skeletal muscle: 51.1706% (minimum 99%, Missing); skin: 58.3969% (minimum 95%, Missing); small intestine: 42.8571% (minimum 99%, Missing); smooth muscle: 57.0896% (minimum 98%, Approved); spinal cord: 47.8125% (minimum 99%, Missing); spleen: 46.7890% (minimum 90%, Approved); stomach: 51.6892% (minimum 97%, Missing); thymus: 44.7368% (minimum 95%, Missing); thyroid gland: 39.5349% (minimum 90%, Approved); tongue: 48.8818% (minimum 97%, Missing); urinary bladder: 56.4576% (minimum 97%, Missing)",-0.504651,-0.506522,-0.620845,0,7,partial,27.3,19.2,23.4,"heart muscle: 27.3 nTPM (vital, limit 2); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 10); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 2); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 4); thymus: 18.9 nTPM (manageable, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); spleen: 17.4 nTPM (manageable, limit 10); duodenum: 17.1 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 4); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 4); tongue: 16 nTPM (protected, limit 2); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 4); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 2); rectum: 13.7 nTPM (protected, limit 4); adipose tissue: 13.2 nTPM (manageable, limit 10); basal ganglia: 13.2 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 2); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 2); urinary bladder: 11.8 nTPM (protected, limit 2); smooth muscle: 11.5 nTPM (vital, limit 2); skin: 10.9 nTPM (manageable, limit 5); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 2); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180628,PCGF5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6842% (minimum 60%, Approved); adrenal gland: 42.0330% (minimum 70%, Approved); amygdala: 50.3289% (minimum 75%, Missing); basal ganglia: 53.6842% (minimum 75%, Missing); cerebellum: 61.2000% (minimum 75%, Missing); cerebral cortex: 45.9459% (minimum 75%, Missing); colon: 50.8306% (minimum 65%, Approved); duodenum: 47.2222% (minimum 75%, Missing); esophagus: 55.2347% (minimum 70%, Missing); heart muscle: 35.9155% (minimum 70%, Approved); hippocampal formation: 54.8387% (minimum 75%, Missing); hypothalamus: 50.6623% (minimum 75%, Missing); kidney: 40.3694% (minimum 75%, Missing); liver: 37.5921% (minimum 75%, Missing); lung: 54.6429% (minimum 70%, Approved); lymph node: 48.2650% (minimum 65%, Approved); midbrain: 49.1961% (minimum 75%, Missing); pancreas: 49.5146% (minimum 75%, Missing); parathyroid gland: 44.3478% (minimum 65%, Approved); pituitary gland: 68.6099% (minimum 75%, Missing); rectum: 52.7586% (minimum 65%, Approved); retina: 49.3548% (minimum 75%, Missing); salivary gland: 47.2222% (minimum 65%, Approved); skeletal muscle: 51.1706% (minimum 75%, Missing); skin: 58.3969% (minimum 65%, Missing); small intestine: 42.8571% (minimum 75%, Missing); smooth muscle: 57.0896% (minimum 70%, Approved); spinal cord: 47.8125% (minimum 75%, Missing); spleen: 46.7890% (minimum 60%, Approved); stomach: 51.6892% (minimum 70%, Missing); thymus: 44.7368% (minimum 65%, Missing); thyroid gland: 39.5349% (minimum 60%, Approved); tongue: 48.8818% (minimum 70%, Missing); urinary bladder: 56.4576% (minimum 70%, Missing)",-0.204651,-0.211182,-0.374079,0,7,partial,27.3,19.2,23.4,"heart muscle: 27.3 nTPM (vital, limit 2); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 10); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 2); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 4); thymus: 18.9 nTPM (manageable, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); spleen: 17.4 nTPM (manageable, limit 10); duodenum: 17.1 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 4); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 4); tongue: 16 nTPM (protected, limit 2); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 4); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 2); rectum: 13.7 nTPM (protected, limit 4); adipose tissue: 13.2 nTPM (manageable, limit 10); basal ganglia: 13.2 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 2); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 2); urinary bladder: 11.8 nTPM (protected, limit 2); smooth muscle: 11.5 nTPM (vital, limit 2); skin: 10.9 nTPM (manageable, limit 5); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 2); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180628,PCGF5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6842% (minimum 60%, Approved); adrenal gland: 42.0330% (minimum 70%, Approved); amygdala: 50.3289% (minimum 75%, Missing); basal ganglia: 53.6842% (minimum 75%, Missing); cerebellum: 61.2000% (minimum 75%, Missing); cerebral cortex: 45.9459% (minimum 75%, Missing); colon: 50.8306% (minimum 65%, Approved); duodenum: 47.2222% (minimum 75%, Missing); esophagus: 55.2347% (minimum 70%, Missing); heart muscle: 35.9155% (minimum 70%, Approved); hippocampal formation: 54.8387% (minimum 75%, Missing); hypothalamus: 50.6623% (minimum 75%, Missing); kidney: 40.3694% (minimum 75%, Missing); liver: 37.5921% (minimum 75%, Missing); lung: 54.6429% (minimum 70%, Approved); lymph node: 48.2650% (minimum 65%, Approved); midbrain: 49.1961% (minimum 75%, Missing); pancreas: 49.5146% (minimum 75%, Missing); parathyroid gland: 44.3478% (minimum 65%, Approved); pituitary gland: 68.6099% (minimum 75%, Missing); rectum: 52.7586% (minimum 65%, Approved); retina: 49.3548% (minimum 75%, Missing); salivary gland: 47.2222% (minimum 65%, Approved); skeletal muscle: 51.1706% (minimum 75%, Missing); skin: 58.3969% (minimum 65%, Missing); small intestine: 42.8571% (minimum 75%, Missing); smooth muscle: 57.0896% (minimum 70%, Approved); spinal cord: 47.8125% (minimum 75%, Missing); spleen: 46.7890% (minimum 60%, Approved); stomach: 51.6892% (minimum 70%, Missing); thymus: 44.7368% (minimum 65%, Missing); thyroid gland: 39.5349% (minimum 60%, Approved); tongue: 48.8818% (minimum 70%, Missing); urinary bladder: 56.4576% (minimum 70%, Missing)",-0.204651,-0.211182,-0.374079,0,7,partial,27.3,19.2,23.4,"heart muscle: 27.3 nTPM (vital, limit 2); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 10); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 2); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 4); thymus: 18.9 nTPM (manageable, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); spleen: 17.4 nTPM (manageable, limit 10); duodenum: 17.1 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 4); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 4); tongue: 16 nTPM (protected, limit 3); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 4); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 3); rectum: 13.7 nTPM (protected, limit 4); adipose tissue: 13.2 nTPM (manageable, limit 10); basal ganglia: 13.2 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 2); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 3); urinary bladder: 11.8 nTPM (protected, limit 3); smooth muscle: 11.5 nTPM (vital, limit 2); skin: 10.9 nTPM (manageable, limit 5); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 2); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180628,PCGF5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6842% (minimum 60%, Approved); adrenal gland: 42.0330% (minimum 70%, Approved); amygdala: 50.3289% (minimum 75%, Missing); basal ganglia: 53.6842% (minimum 75%, Missing); cerebellum: 61.2000% (minimum 75%, Missing); cerebral cortex: 45.9459% (minimum 75%, Missing); colon: 50.8306% (minimum 65%, Approved); duodenum: 47.2222% (minimum 75%, Missing); esophagus: 55.2347% (minimum 70%, Missing); heart muscle: 35.9155% (minimum 70%, Approved); hippocampal formation: 54.8387% (minimum 75%, Missing); hypothalamus: 50.6623% (minimum 75%, Missing); kidney: 40.3694% (minimum 75%, Missing); liver: 37.5921% (minimum 75%, Missing); lung: 54.6429% (minimum 70%, Approved); lymph node: 48.2650% (minimum 65%, Approved); midbrain: 49.1961% (minimum 75%, Missing); pancreas: 49.5146% (minimum 75%, Missing); parathyroid gland: 44.3478% (minimum 65%, Approved); pituitary gland: 68.6099% (minimum 75%, Missing); rectum: 52.7586% (minimum 65%, Approved); retina: 49.3548% (minimum 75%, Missing); salivary gland: 47.2222% (minimum 65%, Approved); skeletal muscle: 51.1706% (minimum 75%, Missing); skin: 58.3969% (minimum 65%, Missing); small intestine: 42.8571% (minimum 75%, Missing); smooth muscle: 57.0896% (minimum 70%, Approved); spinal cord: 47.8125% (minimum 75%, Missing); spleen: 46.7890% (minimum 60%, Approved); stomach: 51.6892% (minimum 70%, Missing); thymus: 44.7368% (minimum 65%, Missing); thyroid gland: 39.5349% (minimum 60%, Approved); tongue: 48.8818% (minimum 70%, Missing); urinary bladder: 56.4576% (minimum 70%, Missing)",-0.204651,-0.211182,-0.374079,0,7,partial,27.3,19.2,23.4,"heart muscle: 27.3 nTPM (vital, limit 2); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 10); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 2); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 4); thymus: 18.9 nTPM (manageable, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); spleen: 17.4 nTPM (manageable, limit 10); duodenum: 17.1 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 4); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 4); tongue: 16 nTPM (protected, limit 3); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 4); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 3); rectum: 13.7 nTPM (protected, limit 4); adipose tissue: 13.2 nTPM (manageable, limit 10); basal ganglia: 13.2 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 2); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 3); urinary bladder: 11.8 nTPM (protected, limit 3); smooth muscle: 11.5 nTPM (vital, limit 2); skin: 10.9 nTPM (manageable, limit 5); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 2); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180628,PCGF5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6842% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 42.0330% (minimum 75%, Baseline (adaptation disabled)); amygdala: 50.3289% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 53.6842% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 72.8571% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.2000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 45.9459% (minimum 75%, Baseline (adaptation disabled)); colon: 50.8306% (minimum 70%, Baseline (adaptation disabled)); duodenum: 47.2222% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.2347% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 35.9155% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.8387% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 50.6623% (minimum 75%, Baseline (adaptation disabled)); kidney: 40.3694% (minimum 75%, Baseline (adaptation disabled)); liver: 37.5921% (minimum 75%, Baseline (adaptation disabled)); lung: 54.6429% (minimum 75%, Baseline (adaptation disabled)); lymph node: 48.2650% (minimum 70%, Baseline (adaptation disabled)); midbrain: 49.1961% (minimum 75%, Baseline (adaptation disabled)); pancreas: 49.5146% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 44.3478% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 68.6099% (minimum 75%, Baseline (adaptation disabled)); rectum: 52.7586% (minimum 70%, Baseline (adaptation disabled)); retina: 49.3548% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 47.2222% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 51.1706% (minimum 75%, Baseline (adaptation disabled)); skin: 58.3969% (minimum 65%, Baseline (adaptation disabled)); small intestine: 42.8571% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.0896% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 47.8125% (minimum 75%, Baseline (adaptation disabled)); spleen: 46.7890% (minimum 65%, Baseline (adaptation disabled)); stomach: 51.6892% (minimum 70%, Baseline (adaptation disabled)); thymus: 44.7368% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 39.5349% (minimum 65%, Baseline (adaptation disabled)); tongue: 48.8818% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.4576% (minimum 70%, Baseline (adaptation disabled))",-0.254651,-0.256522,-0.390845,0,7,partial,27.3,19.2,23.4,"heart muscle: 27.3 nTPM (vital, limit 1); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 1); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 3); thymus: 18.9 nTPM (manageable, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); spleen: 17.4 nTPM (manageable, limit 5); duodenum: 17.1 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 3); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 3); tongue: 16 nTPM (protected, limit 3); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 3); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 3); rectum: 13.7 nTPM (protected, limit 3); adipose tissue: 13.2 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 3); urinary bladder: 11.8 nTPM (protected, limit 3); smooth muscle: 11.5 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180628,PCGF5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 75.0000% (minimum 99%, Missing); duodenum: 75.0000% (minimum 99%, Missing); salivary gland: 75.0000% (minimum 97%, Missing)",0.05,-0.22,-0.24,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180658,OR2A4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing)",0.35,0.05,-1.11022e-16,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180658,OR2A4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing)",0.35,0.05,-1.11022e-16,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180658,OR2A4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing)",0.35,0.05,-1.11022e-16,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180658,OR2A4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 75.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.05,-1.11022e-16,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180658,OR2A4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180697,C3orf22,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180697,C3orf22,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180697,C3orf22,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180697,C3orf22,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180697,C3orf22,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.9167% (minimum 95%, Missing); adrenal gland: 76.0870% (minimum 99%, Missing); amygdala: 84.0841% (minimum 99%, Missing); basal ganglia: 85.3659% (minimum 99%, Missing); bone marrow: 49.2958% (minimum 99%, Missing); cerebellum: 84.0841% (minimum 99%, Missing); cerebral cortex: 66.0377% (minimum 99%, Missing); choroid plexus: 94.2761% (minimum 99%, Missing); colon: 63.3484% (minimum 97%, Missing); duodenum: 60.4752% (minimum 99%, Missing); esophagus: 49.2091% (minimum 97%, Missing); heart muscle: 79.0960% (minimum 99%, Missing); hippocampal formation: 75.2688% (minimum 99%, Missing); hypothalamus: 76.2943% (minimum 99%, Missing); kidney: 81.3953% (minimum 99%, Missing); liver: 75.0670% (minimum 99%, Missing); lung: 63.4921% (minimum 99%, Missing); lymph node: 61.8102% (minimum 97%, Missing); midbrain: 65.7277% (minimum 99%, Missing); pancreas: 76.2943% (minimum 99%, Missing); parathyroid gland: 76.7123% (minimum 97%, Missing); pituitary gland: 86.6873% (minimum 99%, Missing); rectum: 64.8148% (minimum 97%, Missing); retina: 84.3373% (minimum 99%, Missing); salivary gland: 77.3481% (minimum 97%, Missing); skeletal muscle: 88.0503% (minimum 99%, Missing); skin: 56.9106% (minimum 95%, Missing); small intestine: 60.6061% (minimum 99%, Missing); smooth muscle: 66.1939% (minimum 99%, Missing); spinal cord: 46.2046% (minimum 99%, Missing); spleen: 64.6651% (minimum 95%, Missing); stomach: 42.4242% (minimum 97%, Missing); thymus: 56.5657% (minimum 95%, Missing); thyroid gland: 64.0732% (minimum 95%, Missing); tongue: 75.6757% (minimum 97%, Missing); urinary bladder: 56.2249% (minimum 97%, Missing)",-0.384343,-0.545758,-0.527954,0,3,partial,32.6,38,21.5,"stomach: 38 nTPM (protected, limit 2); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 2); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 2); thymus: 21.5 nTPM (manageable, limit 5); skin: 21.2 nTPM (manageable, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 2); colon: 16.2 nTPM (protected, limit 2); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (manageable, limit 5); spleen: 15.3 nTPM (manageable, limit 5); rectum: 15.2 nTPM (protected, limit 2); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 2); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180776,ZDHHC20,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 49.2958% (minimum 75%, Missing); cerebral cortex: 66.0377% (minimum 75%, Missing); colon: 63.3484% (minimum 70%, Missing); duodenum: 60.4752% (minimum 75%, Missing); esophagus: 49.2091% (minimum 70%, Missing); lung: 63.4921% (minimum 75%, Missing); lymph node: 61.8102% (minimum 70%, Missing); midbrain: 65.7277% (minimum 75%, Missing); rectum: 64.8148% (minimum 70%, Missing); skin: 56.9106% (minimum 65%, Missing); small intestine: 60.6061% (minimum 75%, Missing); smooth muscle: 66.1939% (minimum 75%, Missing); spinal cord: 46.2046% (minimum 75%, Missing); spleen: 64.6651% (minimum 65%, Missing); stomach: 42.4242% (minimum 70%, Missing); thymus: 56.5657% (minimum 65%, Missing); thyroid gland: 64.0732% (minimum 65%, Missing); urinary bladder: 56.2249% (minimum 70%, Missing)",-0.0843434,-0.275758,-0.287954,0,3,partial,32.6,38,21.5,"stomach: 38 nTPM (protected, limit 2); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 2); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 2); thymus: 21.5 nTPM (manageable, limit 5); skin: 21.2 nTPM (manageable, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 2); colon: 16.2 nTPM (protected, limit 2); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (manageable, limit 5); spleen: 15.3 nTPM (manageable, limit 5); rectum: 15.2 nTPM (protected, limit 2); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 2); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180776,ZDHHC20,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 49.2958% (minimum 75%, Missing); cerebral cortex: 66.0377% (minimum 75%, Missing); colon: 63.3484% (minimum 70%, Missing); duodenum: 60.4752% (minimum 75%, Missing); esophagus: 49.2091% (minimum 70%, Missing); lung: 63.4921% (minimum 75%, Missing); lymph node: 61.8102% (minimum 70%, Missing); midbrain: 65.7277% (minimum 75%, Missing); rectum: 64.8148% (minimum 70%, Missing); skin: 56.9106% (minimum 65%, Missing); small intestine: 60.6061% (minimum 75%, Missing); smooth muscle: 66.1939% (minimum 75%, Missing); spinal cord: 46.2046% (minimum 75%, Missing); spleen: 64.6651% (minimum 65%, Missing); stomach: 42.4242% (minimum 70%, Missing); thymus: 56.5657% (minimum 65%, Missing); thyroid gland: 64.0732% (minimum 65%, Missing); urinary bladder: 56.2249% (minimum 70%, Missing)",-0.0843434,-0.275758,-0.287954,0,3,partial,32.6,38,21.5,"stomach: 38 nTPM (protected, limit 3); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 3); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 3); thymus: 21.5 nTPM (manageable, limit 5); skin: 21.2 nTPM (manageable, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 3); colon: 16.2 nTPM (protected, limit 3); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (manageable, limit 5); spleen: 15.3 nTPM (manageable, limit 5); rectum: 15.2 nTPM (protected, limit 3); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 3); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180776,ZDHHC20,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 49.2958% (minimum 75%, Missing); cerebral cortex: 66.0377% (minimum 75%, Missing); colon: 63.3484% (minimum 70%, Missing); duodenum: 60.4752% (minimum 75%, Missing); esophagus: 49.2091% (minimum 70%, Missing); lung: 63.4921% (minimum 75%, Missing); lymph node: 61.8102% (minimum 70%, Missing); midbrain: 65.7277% (minimum 75%, Missing); rectum: 64.8148% (minimum 70%, Missing); skin: 56.9106% (minimum 65%, Missing); small intestine: 60.6061% (minimum 75%, Missing); smooth muscle: 66.1939% (minimum 75%, Missing); spinal cord: 46.2046% (minimum 75%, Missing); spleen: 64.6651% (minimum 65%, Missing); stomach: 42.4242% (minimum 70%, Missing); thymus: 56.5657% (minimum 65%, Missing); thyroid gland: 64.0732% (minimum 65%, Missing); urinary bladder: 56.2249% (minimum 70%, Missing)",-0.0843434,-0.275758,-0.287954,0,3,partial,32.6,38,21.5,"stomach: 38 nTPM (protected, limit 3); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 3); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 3); thymus: 21.5 nTPM (manageable, limit 5); skin: 21.2 nTPM (manageable, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 3); colon: 16.2 nTPM (protected, limit 3); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (manageable, limit 5); spleen: 15.3 nTPM (manageable, limit 5); rectum: 15.2 nTPM (protected, limit 3); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 3); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180776,ZDHHC20,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 49.2958% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.0377% (minimum 75%, Baseline (adaptation disabled)); colon: 63.3484% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.4752% (minimum 75%, Baseline (adaptation disabled)); esophagus: 49.2091% (minimum 70%, Baseline (adaptation disabled)); lung: 63.4921% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.8102% (minimum 70%, Baseline (adaptation disabled)); midbrain: 65.7277% (minimum 75%, Baseline (adaptation disabled)); rectum: 64.8148% (minimum 70%, Baseline (adaptation disabled)); skin: 56.9106% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.6061% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.1939% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 46.2046% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.6651% (minimum 65%, Baseline (adaptation disabled)); stomach: 42.4242% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.5657% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 64.0732% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 56.2249% (minimum 70%, Baseline (adaptation disabled))",-0.0843434,-0.275758,-0.287954,0,3,partial,32.6,38,21.5,"stomach: 38 nTPM (protected, limit 3); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 3); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 3); thymus: 21.5 nTPM (manageable, limit 5); skin: 21.2 nTPM (manageable, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 3); colon: 16.2 nTPM (protected, limit 3); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (manageable, limit 5); spleen: 15.3 nTPM (manageable, limit 5); rectum: 15.2 nTPM (protected, limit 3); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 3); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180776,ZDHHC20,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180872,DEFB112,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180872,DEFB112,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180872,DEFB112,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180872,DEFB112,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180872,DEFB112,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 94.6360% (minimum 99%, Missing)",0.05,0.03,-0.0436398,0,3,partial,1.4,0.3,1.5,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180878,C11orf42,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.19636,0,3,partial,1.4,0.3,1.5,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180878,C11orf42,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.19636,0,3,partial,1.4,0.3,1.5,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180878,C11orf42,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.19636,0,3,partial,1.4,0.3,1.5,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180878,C11orf42,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.292748,0.288,0.19636,0,3,partial,1.4,0.3,1.5,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180878,C11orf42,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 50.0000% (minimum 99%, Missing); liver: 66.6667% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); spleen: 66.6667% (minimum 95%, Missing)",-0.283333,-0.303333,-0.49,9,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180934,OR56A1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 50.0000% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing)",0.0166667,-0.0333333,-0.25,9,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180934,OR56A1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 50.0000% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing)",0.0166667,-0.0333333,-0.25,9,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180934,OR56A1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 50.0000% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing)",0.0166667,-0.0333333,-0.25,9,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180934,OR56A1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 50.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled))",0.0166667,-0.0333333,-0.25,9,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180934,OR56A1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.3659% (minimum 90%, Approved); adrenal gland: 92.1053% (minimum 99%, Missing); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 97.2222% (minimum 98%, Approved); cerebellum: 89.7436% (minimum 99%, Missing); cerebral cortex: 77.7778% (minimum 99%, Missing); choroid plexus: 81.3953% (minimum 99%, Missing); colon: 77.7778% (minimum 97%, Missing); duodenum: 79.5455% (minimum 99%, Missing); esophagus: 87.5000% (minimum 97%, Missing); heart muscle: 79.5455% (minimum 99%, Missing); hippocampal formation: 85.3659% (minimum 99%, Missing); hypothalamus: 85.3659% (minimum 99%, Missing); kidney: 68.6275% (minimum 99%, Missing); liver: 79.5455% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 66.0377% (minimum 95%, Approved); midbrain: 83.3333% (minimum 99%, Missing); pancreas: 77.7778% (minimum 99%, Missing); parathyroid gland: 87.5000% (minimum 97%, Missing); pituitary gland: 92.1053% (minimum 99%, Missing); rectum: 72.9167% (minimum 97%, Missing); retina: 66.0377% (minimum 99%, Missing); salivary gland: 72.9167% (minimum 97%, Missing); skeletal muscle: 94.5946% (minimum 98%, Approved); skin: 81.3953% (minimum 95%, Missing); small intestine: 79.5455% (minimum 99%, Missing); smooth muscle: 81.3953% (minimum 99%, Missing); spinal cord: 77.7778% (minimum 99%, Missing); spleen: 71.4286% (minimum 90%, Approved); stomach: 71.4286% (minimum 97%, Missing); thymus: 66.0377% (minimum 95%, Missing); thyroid gland: 67.3077% (minimum 95%, Missing); tongue: 94.5946% (minimum 97%, Missing); urinary bladder: 76.0870% (minimum 97%, Missing)",-0.289623,-0.289623,-0.329623,0,1,partial,1.8,1.8,1.8,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180938,ZNF572,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 68.6275% (minimum 75%, Missing); retina: 66.0377% (minimum 75%, Missing)",0.0103774,0.0103774,-0.0896226,0,1,partial,1.8,1.8,1.8,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180938,ZNF572,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 68.6275% (minimum 75%, Missing); retina: 66.0377% (minimum 75%, Missing)",0.0103774,0.0103774,-0.0896226,0,1,partial,1.8,1.8,1.8,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180938,ZNF572,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 68.6275% (minimum 75%, Missing); retina: 66.0377% (minimum 75%, Missing)",0.0103774,0.0103774,-0.0896226,0,1,partial,1.8,1.8,1.8,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180938,ZNF572,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 68.6275% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.0377% (minimum 70%, Baseline (adaptation disabled)); retina: 66.0377% (minimum 75%, Baseline (adaptation disabled))",0.0103774,-0.0396226,-0.0896226,0,1,partial,1.8,1.8,1.8,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180938,ZNF572,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 83.3333% (minimum 99%, Missing); bone marrow: 71.4286% (minimum 99%, Missing); cerebral cortex: 83.3333% (minimum 99%, Missing); duodenum: 83.3333% (minimum 99%, Missing); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 83.3333% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lymph node: 83.3333% (minimum 97%, Missing); pancreas: 83.3333% (minimum 99%, Missing); parathyroid gland: 83.3333% (minimum 97%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 45.4545% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 71.4286% (minimum 99%, Missing); skin: 55.5556% (minimum 95%, Missing); small intestine: 83.3333% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 83.3333% (minimum 97%, Missing); thyroid gland: 62.5000% (minimum 95%, Missing)",-0.394444,-0.136667,-0.535455,0,80,unavailable,0.6,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180974,OR52E4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); retina: 45.4545% (minimum 75%, Missing); skeletal muscle: 71.4286% (minimum 75%, Missing); skin: 55.5556% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing)",-0.0944444,0.133333,-0.295455,0,80,unavailable,0.6,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180974,OR52E4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); retina: 45.4545% (minimum 75%, Missing); skeletal muscle: 71.4286% (minimum 75%, Missing); skin: 55.5556% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing)",-0.0944444,0.133333,-0.295455,0,80,unavailable,0.6,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180974,OR52E4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); retina: 45.4545% (minimum 75%, Missing); skeletal muscle: 71.4286% (minimum 75%, Missing); skin: 55.5556% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing)",-0.0944444,0.133333,-0.295455,0,80,unavailable,0.6,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180974,OR52E4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 71.4286% (minimum 75%, Baseline (adaptation disabled)); retina: 45.4545% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); skin: 55.5556% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.5000% (minimum 65%, Baseline (adaptation disabled))",-0.0944444,0.133333,-0.295455,0,80,unavailable,0.6,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000180974,OR52E4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.0657% (minimum 99%, Missing); heart muscle: 60.2837% (minimum 99%, Missing); pancreas: 98.0769% (minimum 99%, Missing); salivary gland: 95.5056% (minimum 97%, Missing); skeletal muscle: 95.1493% (minimum 99%, Missing); small intestine: 97.7011% (minimum 99%, Missing); tongue: 88.8502% (minimum 97%, Missing)",0.0270115,-0.0814983,-0.387163,0,80,unavailable,16.8,3.2,0.6,"heart muscle: 16.8 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180999,C1orf105,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 60.2837% (minimum 75%, Missing)",0.327011,0.188502,-0.147163,0,80,unavailable,16.8,3.2,0.6,"heart muscle: 16.8 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180999,C1orf105,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 60.2837% (minimum 75%, Missing)",0.327011,0.188502,-0.147163,0,80,unavailable,16.8,3.2,0.6,"heart muscle: 16.8 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180999,C1orf105,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 60.2837% (minimum 75%, Missing)",0.327011,0.188502,-0.147163,0,80,unavailable,16.8,3.2,0.6,"heart muscle: 16.8 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180999,C1orf105,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 60.2837% (minimum 75%, Baseline (adaptation disabled))",0.327011,0.188502,-0.147163,0,80,unavailable,16.8,3.2,0.6,"heart muscle: 16.8 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000180999,C1orf105,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.5460% (minimum 95%, Uncertain); adrenal gland: 67.7159% (minimum 99%, Missing); amygdala: 64.0058% (minimum 99%, Missing); basal ganglia: 63.4076% (minimum 99%, Missing); bone marrow: 73.9003% (minimum 99%, Missing); cerebellum: 74.4304% (minimum 99%, Uncertain); cerebral cortex: 64.5208% (minimum 99%, Missing); choroid plexus: 66.7171% (minimum 99%, Missing); colon: 77.4363% (minimum 97%, Missing); duodenum: 86.8538% (minimum 99%, Missing); esophagus: 67.9507% (minimum 97%, Uncertain); heart muscle: 63.4076% (minimum 99%, Missing); hippocampal formation: 64.5208% (minimum 99%, Missing); hypothalamus: 67.4312% (minimum 99%, Missing); kidney: 70.5600% (minimum 99%, Missing); liver: 64.4737% (minimum 99%, Uncertain); lung: 83.5227% (minimum 99%, Missing); lymph node: 88.5542% (minimum 97%, Missing); midbrain: 68.5315% (minimum 99%, Missing); pancreas: 73.0132% (minimum 99%, Missing); parathyroid gland: 90.2302% (minimum 97%, Missing); pituitary gland: 75.6432% (minimum 99%, Missing); rectum: 95.6098% (minimum 97%, Missing); retina: 95.2998% (minimum 99%, Missing); salivary gland: 73.7150% (minimum 97%, Missing); skeletal muscle: 61.9382% (minimum 99%, Missing); skin: 66.7676% (minimum 95%, Missing); small intestine: 78.8909% (minimum 99%, Missing); smooth muscle: 94.0299% (minimum 99%, Uncertain); spinal cord: 73.4694% (minimum 99%, Missing); spleen: 74.9045% (minimum 95%, Missing); stomach: 75.9363% (minimum 97%, Missing); thymus: 91.5413% (minimum 95%, Missing); thyroid gland: 76.4629% (minimum 95%, Missing); tongue: 87.1111% (minimum 97%, Missing); urinary bladder: 76.6623% (minimum 97%, Uncertain)",-0.282324,-0.290493,-0.370618,0,1,partial,108.4,83.2,87.8,"skeletal muscle: 108.4 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); skin: 87.8 nTPM (manageable, limit 5); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 2); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); salivary gland: 62.9 nTPM (protected, limit 2); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); spleen: 59.1 nTPM (manageable, limit 5); adipose tissue: 57.1 nTPM (manageable, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 2); thyroid gland: 54.3 nTPM (manageable, limit 5); urinary bladder: 53.7 nTPM (protected, limit 2); colon: 51.4 nTPM (protected, limit 2); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 2); lymph node: 22.8 nTPM (protected, limit 2); parathyroid gland: 19.1 nTPM (protected, limit 2); thymus: 16.3 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181029,TRAPPC5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.7159% (minimum 75%, Missing); amygdala: 64.0058% (minimum 75%, Missing); basal ganglia: 63.4076% (minimum 75%, Missing); bone marrow: 73.9003% (minimum 75%, Missing); cerebellum: 74.4304% (minimum 75%, Uncertain); cerebral cortex: 64.5208% (minimum 75%, Missing); choroid plexus: 66.7171% (minimum 75%, Missing); esophagus: 67.9507% (minimum 70%, Uncertain); heart muscle: 63.4076% (minimum 75%, Missing); hippocampal formation: 64.5208% (minimum 75%, Missing); hypothalamus: 67.4312% (minimum 75%, Missing); kidney: 70.5600% (minimum 75%, Missing); liver: 64.4737% (minimum 75%, Uncertain); midbrain: 68.5315% (minimum 75%, Missing); pancreas: 73.0132% (minimum 75%, Missing); skeletal muscle: 61.9382% (minimum 75%, Missing); spinal cord: 73.4694% (minimum 75%, Missing)",0.017676,-0.0204931,-0.130618,0,1,partial,108.4,83.2,87.8,"skeletal muscle: 108.4 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); skin: 87.8 nTPM (manageable, limit 5); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 2); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); salivary gland: 62.9 nTPM (protected, limit 2); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); spleen: 59.1 nTPM (manageable, limit 5); adipose tissue: 57.1 nTPM (manageable, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 2); thyroid gland: 54.3 nTPM (manageable, limit 5); urinary bladder: 53.7 nTPM (protected, limit 2); colon: 51.4 nTPM (protected, limit 2); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 2); lymph node: 22.8 nTPM (protected, limit 2); parathyroid gland: 19.1 nTPM (protected, limit 2); thymus: 16.3 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181029,TRAPPC5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.7159% (minimum 75%, Missing); amygdala: 64.0058% (minimum 75%, Missing); basal ganglia: 63.4076% (minimum 75%, Missing); bone marrow: 73.9003% (minimum 75%, Missing); cerebellum: 74.4304% (minimum 75%, Uncertain); cerebral cortex: 64.5208% (minimum 75%, Missing); choroid plexus: 66.7171% (minimum 75%, Missing); esophagus: 67.9507% (minimum 70%, Uncertain); heart muscle: 63.4076% (minimum 75%, Missing); hippocampal formation: 64.5208% (minimum 75%, Missing); hypothalamus: 67.4312% (minimum 75%, Missing); kidney: 70.5600% (minimum 75%, Missing); liver: 64.4737% (minimum 75%, Uncertain); midbrain: 68.5315% (minimum 75%, Missing); pancreas: 73.0132% (minimum 75%, Missing); skeletal muscle: 61.9382% (minimum 75%, Missing); spinal cord: 73.4694% (minimum 75%, Missing)",0.017676,-0.0204931,-0.130618,0,1,partial,108.4,83.2,87.8,"skeletal muscle: 108.4 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); skin: 87.8 nTPM (manageable, limit 5); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 3); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); salivary gland: 62.9 nTPM (protected, limit 3); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); spleen: 59.1 nTPM (manageable, limit 5); adipose tissue: 57.1 nTPM (manageable, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 3); thyroid gland: 54.3 nTPM (manageable, limit 5); urinary bladder: 53.7 nTPM (protected, limit 3); colon: 51.4 nTPM (protected, limit 3); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 3); lymph node: 22.8 nTPM (protected, limit 3); parathyroid gland: 19.1 nTPM (protected, limit 3); thymus: 16.3 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181029,TRAPPC5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.7159% (minimum 75%, Missing); amygdala: 64.0058% (minimum 75%, Missing); basal ganglia: 63.4076% (minimum 75%, Missing); bone marrow: 73.9003% (minimum 75%, Missing); cerebellum: 74.4304% (minimum 75%, Uncertain); cerebral cortex: 64.5208% (minimum 75%, Missing); choroid plexus: 66.7171% (minimum 75%, Missing); esophagus: 67.9507% (minimum 70%, Uncertain); heart muscle: 63.4076% (minimum 75%, Missing); hippocampal formation: 64.5208% (minimum 75%, Missing); hypothalamus: 67.4312% (minimum 75%, Missing); kidney: 70.5600% (minimum 75%, Missing); liver: 64.4737% (minimum 75%, Uncertain); midbrain: 68.5315% (minimum 75%, Missing); pancreas: 73.0132% (minimum 75%, Missing); skeletal muscle: 61.9382% (minimum 75%, Missing); spinal cord: 73.4694% (minimum 75%, Missing)",0.017676,-0.0204931,-0.130618,0,1,partial,108.4,83.2,87.8,"skeletal muscle: 108.4 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); skin: 87.8 nTPM (manageable, limit 5); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 3); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); salivary gland: 62.9 nTPM (protected, limit 3); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); spleen: 59.1 nTPM (manageable, limit 5); adipose tissue: 57.1 nTPM (manageable, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 3); thyroid gland: 54.3 nTPM (manageable, limit 5); urinary bladder: 53.7 nTPM (protected, limit 3); colon: 51.4 nTPM (protected, limit 3); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 3); lymph node: 22.8 nTPM (protected, limit 3); parathyroid gland: 19.1 nTPM (protected, limit 3); thymus: 16.3 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181029,TRAPPC5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.7159% (minimum 75%, Baseline (adaptation disabled)); amygdala: 64.0058% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 63.4076% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 73.9003% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.4304% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.5208% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.7171% (minimum 75%, Baseline (adaptation disabled)); esophagus: 67.9507% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.4076% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.5208% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.4312% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.5600% (minimum 75%, Baseline (adaptation disabled)); liver: 64.4737% (minimum 75%, Baseline (adaptation disabled)); midbrain: 68.5315% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.0132% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 61.9382% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.4694% (minimum 75%, Baseline (adaptation disabled))",0.017676,-0.0204931,-0.130618,0,1,partial,108.4,83.2,87.8,"skeletal muscle: 108.4 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); skin: 87.8 nTPM (manageable, limit 5); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 3); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); salivary gland: 62.9 nTPM (protected, limit 3); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); spleen: 59.1 nTPM (manageable, limit 5); adipose tissue: 57.1 nTPM (manageable, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 3); thyroid gland: 54.3 nTPM (manageable, limit 5); urinary bladder: 53.7 nTPM (protected, limit 3); colon: 51.4 nTPM (protected, limit 3); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 3); lymph node: 22.8 nTPM (protected, limit 3); parathyroid gland: 19.1 nTPM (protected, limit 3); thymus: 16.3 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181029,TRAPPC5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 25.5657% (minimum 99%, Missing); amygdala: 86.1264% (minimum 99%, Missing); basal ganglia: 14.5139% (minimum 99%, Missing); cerebellum: 79.8726% (minimum 95%, Enhanced); cerebral cortex: 94.5701% (minimum 95%, Enhanced); choroid plexus: 98.1221% (minimum 99%, Missing); colon: 84.9018% (minimum 97%, Missing); heart muscle: 83.5443% (minimum 95%, Enhanced); hippocampal formation: 96.4615% (minimum 99%, Missing); hypothalamus: 60.3755% (minimum 99%, Missing); midbrain: 97.2847% (minimum 99%, Missing); pituitary gland: 88.3099% (minimum 99%, Missing); small intestine: 96.8340% (minimum 99%, Missing); spinal cord: 83.1014% (minimum 99%, Missing); tongue: 96.0920% (minimum 97%, Missing)",0.0484076,-0.120982,-0.844861,0,7,partial,738.6,22.3,8.3,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 6); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 6); colon: 22.3 nTPM (protected, limit 2); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 6); tongue: 5.1 nTPM (protected, limit 2); hippocampal formation: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181195,PENK,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 25.5657% (minimum 75%, Missing); basal ganglia: 14.5139% (minimum 75%, Missing); hypothalamus: 60.3755% (minimum 75%, Missing)",0.348408,0.149018,-0.604861,0,7,partial,738.6,22.3,8.3,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 6); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 6); colon: 22.3 nTPM (protected, limit 2); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 6); tongue: 5.1 nTPM (protected, limit 2); hippocampal formation: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181195,PENK,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 25.5657% (minimum 75%, Missing); basal ganglia: 14.5139% (minimum 75%, Missing); hypothalamus: 60.3755% (minimum 75%, Missing)",0.348408,0.149018,-0.604861,0,7,partial,738.6,22.3,8.3,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 6); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 6); colon: 22.3 nTPM (protected, limit 3); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 6); tongue: 5.1 nTPM (protected, limit 3); hippocampal formation: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181195,PENK,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 25.5657% (minimum 75%, Missing); basal ganglia: 14.5139% (minimum 75%, Missing); hypothalamus: 60.3755% (minimum 75%, Missing)",0.348408,0.149018,-0.604861,0,7,partial,738.6,22.3,8.3,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 6); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 6); colon: 22.3 nTPM (protected, limit 3); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 6); tongue: 5.1 nTPM (protected, limit 3); hippocampal formation: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181195,PENK,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 25.5657% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 14.5139% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.3755% (minimum 75%, Baseline (adaptation disabled))",0.287921,0.149018,-0.604861,0,7,partial,738.6,22.3,8.3,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 1); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 1); colon: 22.3 nTPM (protected, limit 3); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 3); adipose tissue: 8.3 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 3); hippocampal formation: 4.6 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); skeletal muscle: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181195,PENK,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.0452% (minimum 99%, Missing); amygdala: 80.1887% (minimum 99%, Missing); basal ganglia: 75.8929% (minimum 99%, Missing); bone marrow: 85.8586% (minimum 95%, Enhanced); cerebellum: 79.0698% (minimum 95%, Enhanced); cerebral cortex: 79.0698% (minimum 95%, Enhanced); choroid plexus: 45.8221% (minimum 99%, Missing); duodenum: 98.8372% (minimum 99%, Missing); hippocampal formation: 78.3410% (minimum 99%, Missing); hypothalamus: 72.0339% (minimum 99%, Missing); kidney: 94.9721% (minimum 95%, Enhanced); lung: 89.0052% (minimum 95%, Enhanced); midbrain: 82.9268% (minimum 99%, Missing); pancreas: 93.4066% (minimum 95%, Enhanced); pituitary gland: 82.5243% (minimum 99%, Missing); retina: 70.2479% (minimum 99%, Missing); skeletal muscle: 86.7347% (minimum 95%, Enhanced); small intestine: 95.5056% (minimum 99%, Missing); spinal cord: 82.1256% (minimum 99%, Missing); thyroid gland: 93.9227% (minimum 95%, Missing)",-0.0107735,0.00142857,-0.531779,0,12,partial,20.1,1.6,1.1,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181322,NME9,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 45.8221% (minimum 75%, Missing); hypothalamus: 72.0339% (minimum 75%, Missing); retina: 70.2479% (minimum 75%, Missing)",0.289227,0.271429,-0.291779,0,12,partial,20.1,1.6,1.1,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181322,NME9,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 45.8221% (minimum 75%, Missing); hypothalamus: 72.0339% (minimum 75%, Missing); retina: 70.2479% (minimum 75%, Missing)",0.289227,0.271429,-0.291779,0,12,partial,20.1,1.6,1.1,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181322,NME9,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 45.8221% (minimum 75%, Missing); hypothalamus: 72.0339% (minimum 75%, Missing); retina: 70.2479% (minimum 75%, Missing)",0.289227,0.271429,-0.291779,0,12,partial,20.1,1.6,1.1,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181322,NME9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 45.8221% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.0339% (minimum 75%, Baseline (adaptation disabled)); retina: 70.2479% (minimum 75%, Baseline (adaptation disabled))",0.289227,0.213978,-0.291779,0,12,partial,20.1,1.6,1.1,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181322,NME9,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.00701493,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181323,SPEM1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247015,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181323,SPEM1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247015,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181323,SPEM1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247015,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181323,SPEM1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247015,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181323,SPEM1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000181371,OR5M8,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000181371,OR5M8,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000181371,OR5M8,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000181371,OR5M8,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000181371,OR5M8,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.9167% (minimum 99%, Missing); choroid plexus: 95.9184% (minimum 99%, Missing); hippocampal formation: 97.9167% (minimum 99%, Missing); hypothalamus: 97.9167% (minimum 99%, Missing); midbrain: 97.9167% (minimum 99%, Missing); pituitary gland: 97.9167% (minimum 99%, Missing); spinal cord: 95.9184% (minimum 99%, Missing)",0.05,0.03,-0.0308163,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181433,SAGE1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.209184,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181433,SAGE1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.209184,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181433,SAGE1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.209184,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181433,SAGE1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.209184,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181433,SAGE1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.1212% (minimum 95%, Missing); adrenal gland: 57.7465% (minimum 99%, Missing); amygdala: 73.2143% (minimum 99%, Missing); basal ganglia: 74.5455% (minimum 99%, Missing); bone marrow: 53.9474% (minimum 99%, Missing); cerebellum: 69.4915% (minimum 99%, Missing); cerebral cortex: 51.8987% (minimum 99%, Missing); choroid plexus: 82.0000% (minimum 99%, Missing); colon: 59.4203% (minimum 97%, Missing); duodenum: 65.0794% (minimum 99%, Missing); esophagus: 67.2131% (minimum 97%, Missing); heart muscle: 69.4915% (minimum 99%, Missing); hippocampal formation: 74.5455% (minimum 99%, Missing); hypothalamus: 75.9259% (minimum 99%, Missing); kidney: 62.1212% (minimum 99%, Missing); liver: 66.1290% (minimum 99%, Missing); lung: 56.9444% (minimum 99%, Missing); lymph node: 48.2353% (minimum 97%, Missing); midbrain: 73.2143% (minimum 99%, Missing); pancreas: 56.1644% (minimum 99%, Missing); parathyroid gland: 64.0625% (minimum 97%, Missing); pituitary gland: 73.2143% (minimum 99%, Missing); rectum: 51.2500% (minimum 97%, Missing); retina: 41.8367% (minimum 99%, Missing); salivary gland: 60.2941% (minimum 97%, Missing); skeletal muscle: 74.5455% (minimum 99%, Missing); skin: 73.2143% (minimum 95%, Missing); small intestine: 65.0794% (minimum 99%, Missing); smooth muscle: 64.0625% (minimum 99%, Missing); spinal cord: 69.4915% (minimum 99%, Missing); spleen: 53.2468% (minimum 95%, Missing); stomach: 56.1644% (minimum 97%, Missing); thymus: 48.8095% (minimum 95%, Missing); thyroid gland: 43.6170% (minimum 95%, Missing); tongue: 61.1940% (minimum 97%, Missing); urinary bladder: 66.1290% (minimum 97%, Missing)",-0.51383,-0.487647,-0.571633,0,80,unavailable,5.7,4.4,5.3,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); tongue: 2.6 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181450,ZNF678,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.1212% (minimum 65%, Missing); adrenal gland: 57.7465% (minimum 75%, Missing); amygdala: 73.2143% (minimum 75%, Missing); basal ganglia: 74.5455% (minimum 75%, Missing); bone marrow: 53.9474% (minimum 75%, Missing); cerebellum: 69.4915% (minimum 75%, Missing); cerebral cortex: 51.8987% (minimum 75%, Missing); colon: 59.4203% (minimum 70%, Missing); duodenum: 65.0794% (minimum 75%, Missing); esophagus: 67.2131% (minimum 70%, Missing); heart muscle: 69.4915% (minimum 75%, Missing); hippocampal formation: 74.5455% (minimum 75%, Missing); kidney: 62.1212% (minimum 75%, Missing); liver: 66.1290% (minimum 75%, Missing); lung: 56.9444% (minimum 75%, Missing); lymph node: 48.2353% (minimum 70%, Missing); midbrain: 73.2143% (minimum 75%, Missing); pancreas: 56.1644% (minimum 75%, Missing); parathyroid gland: 64.0625% (minimum 70%, Missing); pituitary gland: 73.2143% (minimum 75%, Missing); rectum: 51.2500% (minimum 70%, Missing); retina: 41.8367% (minimum 75%, Missing); salivary gland: 60.2941% (minimum 70%, Missing); skeletal muscle: 74.5455% (minimum 75%, Missing); small intestine: 65.0794% (minimum 75%, Missing); smooth muscle: 64.0625% (minimum 75%, Missing); spinal cord: 69.4915% (minimum 75%, Missing); spleen: 53.2468% (minimum 65%, Missing); stomach: 56.1644% (minimum 70%, Missing); thymus: 48.8095% (minimum 65%, Missing); thyroid gland: 43.6170% (minimum 65%, Missing); tongue: 61.1940% (minimum 70%, Missing); urinary bladder: 66.1290% (minimum 70%, Missing)",-0.21383,-0.217647,-0.331633,0,80,unavailable,5.7,4.4,5.3,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); tongue: 2.6 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181450,ZNF678,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.1212% (minimum 65%, Missing); adrenal gland: 57.7465% (minimum 75%, Missing); amygdala: 73.2143% (minimum 75%, Missing); basal ganglia: 74.5455% (minimum 75%, Missing); bone marrow: 53.9474% (minimum 75%, Missing); cerebellum: 69.4915% (minimum 75%, Missing); cerebral cortex: 51.8987% (minimum 75%, Missing); colon: 59.4203% (minimum 70%, Missing); duodenum: 65.0794% (minimum 75%, Missing); esophagus: 67.2131% (minimum 70%, Missing); heart muscle: 69.4915% (minimum 75%, Missing); hippocampal formation: 74.5455% (minimum 75%, Missing); kidney: 62.1212% (minimum 75%, Missing); liver: 66.1290% (minimum 75%, Missing); lung: 56.9444% (minimum 75%, Missing); lymph node: 48.2353% (minimum 70%, Missing); midbrain: 73.2143% (minimum 75%, Missing); pancreas: 56.1644% (minimum 75%, Missing); parathyroid gland: 64.0625% (minimum 70%, Missing); pituitary gland: 73.2143% (minimum 75%, Missing); rectum: 51.2500% (minimum 70%, Missing); retina: 41.8367% (minimum 75%, Missing); salivary gland: 60.2941% (minimum 70%, Missing); skeletal muscle: 74.5455% (minimum 75%, Missing); small intestine: 65.0794% (minimum 75%, Missing); smooth muscle: 64.0625% (minimum 75%, Missing); spinal cord: 69.4915% (minimum 75%, Missing); spleen: 53.2468% (minimum 65%, Missing); stomach: 56.1644% (minimum 70%, Missing); thymus: 48.8095% (minimum 65%, Missing); thyroid gland: 43.6170% (minimum 65%, Missing); tongue: 61.1940% (minimum 70%, Missing); urinary bladder: 66.1290% (minimum 70%, Missing)",-0.21383,-0.217647,-0.331633,0,80,unavailable,5.7,4.4,5.3,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181450,ZNF678,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.1212% (minimum 65%, Missing); adrenal gland: 57.7465% (minimum 75%, Missing); amygdala: 73.2143% (minimum 75%, Missing); basal ganglia: 74.5455% (minimum 75%, Missing); bone marrow: 53.9474% (minimum 75%, Missing); cerebellum: 69.4915% (minimum 75%, Missing); cerebral cortex: 51.8987% (minimum 75%, Missing); colon: 59.4203% (minimum 70%, Missing); duodenum: 65.0794% (minimum 75%, Missing); esophagus: 67.2131% (minimum 70%, Missing); heart muscle: 69.4915% (minimum 75%, Missing); hippocampal formation: 74.5455% (minimum 75%, Missing); kidney: 62.1212% (minimum 75%, Missing); liver: 66.1290% (minimum 75%, Missing); lung: 56.9444% (minimum 75%, Missing); lymph node: 48.2353% (minimum 70%, Missing); midbrain: 73.2143% (minimum 75%, Missing); pancreas: 56.1644% (minimum 75%, Missing); parathyroid gland: 64.0625% (minimum 70%, Missing); pituitary gland: 73.2143% (minimum 75%, Missing); rectum: 51.2500% (minimum 70%, Missing); retina: 41.8367% (minimum 75%, Missing); salivary gland: 60.2941% (minimum 70%, Missing); skeletal muscle: 74.5455% (minimum 75%, Missing); small intestine: 65.0794% (minimum 75%, Missing); smooth muscle: 64.0625% (minimum 75%, Missing); spinal cord: 69.4915% (minimum 75%, Missing); spleen: 53.2468% (minimum 65%, Missing); stomach: 56.1644% (minimum 70%, Missing); thymus: 48.8095% (minimum 65%, Missing); thyroid gland: 43.6170% (minimum 65%, Missing); tongue: 61.1940% (minimum 70%, Missing); urinary bladder: 66.1290% (minimum 70%, Missing)",-0.21383,-0.217647,-0.331633,0,80,unavailable,5.7,4.4,5.3,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181450,ZNF678,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.1212% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 57.7465% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.2143% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.5455% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 53.9474% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 69.4915% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.8987% (minimum 75%, Baseline (adaptation disabled)); colon: 59.4203% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.0794% (minimum 75%, Baseline (adaptation disabled)); esophagus: 67.2131% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.4915% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.5455% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.1212% (minimum 75%, Baseline (adaptation disabled)); liver: 66.1290% (minimum 75%, Baseline (adaptation disabled)); lung: 56.9444% (minimum 75%, Baseline (adaptation disabled)); lymph node: 48.2353% (minimum 70%, Baseline (adaptation disabled)); midbrain: 73.2143% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.1644% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.0625% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 73.2143% (minimum 75%, Baseline (adaptation disabled)); rectum: 51.2500% (minimum 70%, Baseline (adaptation disabled)); retina: 41.8367% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.2941% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 74.5455% (minimum 75%, Baseline (adaptation disabled)); small intestine: 65.0794% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.0625% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.4915% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.2468% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.1644% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.8095% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 43.6170% (minimum 65%, Baseline (adaptation disabled)); tongue: 61.1940% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 66.1290% (minimum 70%, Baseline (adaptation disabled))",-0.21383,-0.217647,-0.331633,0,80,unavailable,5.7,4.4,5.3,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181450,ZNF678,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,0,routine_complete,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181552,EDDM3B,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181552,EDDM3B,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181552,EDDM3B,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181552,EDDM3B,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181552,EDDM3B,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00967799,0,5,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181562,EDDM3A,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.249678,0,5,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181562,EDDM3A,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.249678,0,5,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181562,EDDM3A,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.249678,0,5,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181562,EDDM3A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.248874,0,5,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181562,EDDM3A,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181609,OR52D1,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181609,OR52D1,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181609,OR52D1,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181609,OR52D1,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181609,OR52D1,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181616,OR52H1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181616,OR52H1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181616,OR52H1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181616,OR52H1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181616,OR52H1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 64.0000% (minimum 95%, Enhanced)",0.05,0.03,-0.31,0,3,partial,0.9,0.2,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181626,ANKRD62,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.35,0.3,0.04,0,3,partial,0.9,0.2,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181626,ANKRD62,selectivity_revised,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.35,0.3,0.04,0,3,partial,0.9,0.2,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181626,ANKRD62,grid_revised,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.35,0.3,0.04,0,3,partial,0.9,0.2,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181626,ANKRD62,current_adaptive,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 64.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.188889,-0.11,0,3,partial,0.9,0.2,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181626,ANKRD62,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 78.8660% (minimum 95%, Missing); adrenal gland: 79.6875% (minimum 99%, Missing); amygdala: 96.2264% (minimum 99%, Missing); basal ganglia: 94.4444% (minimum 99%, Missing); bone marrow: 83.1522% (minimum 98%, Approved); cerebellum: 90.5325% (minimum 99%, Missing); cerebral cortex: 76.5000% (minimum 99%, Missing); choroid plexus: 88.4393% (minimum 99%, Missing); colon: 90.0000% (minimum 97%, Missing); duodenum: 95.0311% (minimum 98%, Approved); esophagus: 92.7273% (minimum 95%, Approved); heart muscle: 80.9524% (minimum 99%, Missing); hippocampal formation: 93.8650% (minimum 99%, Missing); hypothalamus: 96.2264% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 73.9130% (minimum 99%, Missing); lung: 88.9535% (minimum 99%, Missing); lymph node: 88.9535% (minimum 97%, Missing); midbrain: 96.2264% (minimum 99%, Missing); pancreas: 81.8182% (minimum 99%, Missing); parathyroid gland: 86.9318% (minimum 97%, Missing); pituitary gland: 92.1687% (minimum 99%, Missing); rectum: 91.6168% (minimum 95%, Approved); retina: 64.0167% (minimum 99%, Missing); salivary gland: 83.6066% (minimum 97%, Missing); skeletal muscle: 65.6652% (minimum 99%, Missing); skin: 85.9551% (minimum 95%, Missing); small intestine: 95.0311% (minimum 98%, Approved); smooth muscle: 84.5304% (minimum 99%, Missing); spinal cord: 95.0311% (minimum 99%, Missing); spleen: 85.4749% (minimum 95%, Missing); stomach: 90.0000% (minimum 95%, Approved); thymus: 88.4393% (minimum 95%, Missing); thyroid gland: 75.7426% (minimum 95%, Missing); tongue: 64.0167% (minimum 97%, Missing); urinary bladder: 90.5325% (minimum 97%, Missing)",-0.192574,-0.329833,-0.349833,0,3,partial,8.6,8.6,4.9,"tongue: 8.6 nTPM (protected, limit 2); retina: 8.6 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2); salivary gland: 3 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181722,ZBTB20,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 73.9130% (minimum 75%, Missing); retina: 64.0167% (minimum 75%, Missing); skeletal muscle: 65.6652% (minimum 75%, Missing); tongue: 64.0167% (minimum 70%, Missing)",0.107426,-0.0598326,-0.109833,0,3,partial,8.6,8.6,4.9,"tongue: 8.6 nTPM (protected, limit 2); retina: 8.6 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2); salivary gland: 3 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181722,ZBTB20,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 73.9130% (minimum 75%, Missing); retina: 64.0167% (minimum 75%, Missing); skeletal muscle: 65.6652% (minimum 75%, Missing); tongue: 64.0167% (minimum 70%, Missing)",0.107426,-0.0598326,-0.109833,0,3,partial,8.6,8.6,4.9,"retina: 8.6 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181722,ZBTB20,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 73.9130% (minimum 75%, Missing); retina: 64.0167% (minimum 75%, Missing); skeletal muscle: 65.6652% (minimum 75%, Missing); tongue: 64.0167% (minimum 70%, Missing)",0.107426,-0.0598326,-0.109833,0,3,partial,8.6,8.6,4.9,"retina: 8.6 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181722,ZBTB20,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 73.9130% (minimum 75%, Baseline (adaptation disabled)); retina: 64.0167% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 65.6652% (minimum 75%, Baseline (adaptation disabled)); tongue: 64.0167% (minimum 70%, Baseline (adaptation disabled))",0.107426,-0.0598326,-0.109833,0,3,partial,8.6,8.6,4.9,"retina: 8.6 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181722,ZBTB20,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.7013% (minimum 99%, Missing); amygdala: 98.2759% (minimum 99%, Missing); basal ganglia: 98.2759% (minimum 99%, Missing); cerebral cortex: 98.7013% (minimum 99%, Missing); heart muscle: 98.2759% (minimum 99%, Missing); hippocampal formation: 98.2759% (minimum 99%, Missing); hypothalamus: 98.7013% (minimum 99%, Missing); liver: 98.7013% (minimum 99%, Missing); midbrain: 97.8541% (minimum 99%, Missing); skeletal muscle: 74.0260% (minimum 99%, Missing); spinal cord: 97.0213% (minimum 99%, Missing)",0.0202128,0.0213043,-0.24974,0,80,unavailable,8,0.2,0.7,"skeletal muscle: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181781,CIMAP1D,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 74.0260% (minimum 75%, Missing)",0.320213,0.291304,-0.00974026,0,80,unavailable,8,0.2,0.7,"skeletal muscle: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181781,CIMAP1D,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 74.0260% (minimum 75%, Missing)",0.320213,0.291304,-0.00974026,0,80,unavailable,8,0.2,0.7,"skeletal muscle: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181781,CIMAP1D,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 74.0260% (minimum 75%, Missing)",0.320213,0.291304,-0.00974026,0,80,unavailable,8,0.2,0.7,"skeletal muscle: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181781,CIMAP1D,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 74.0260% (minimum 75%, Baseline (adaptation disabled))",0.320213,0.291304,-0.00974026,0,80,unavailable,8,0.2,0.7,"skeletal muscle: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181781,CIMAP1D,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181786,ACTL9,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181786,ACTL9,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181786,ACTL9,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181786,ACTL9,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181786,ACTL9,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4286% (minimum 90%, Approved); adrenal gland: 61.4035% (minimum 99%, Missing); amygdala: 78.6517% (minimum 99%, Missing); basal ganglia: 76.9231% (minimum 99%, Missing); bone marrow: 52.6316% (minimum 99%, Missing); cerebellum: 56.0000% (minimum 99%, Missing); cerebral cortex: 61.9469% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); colon: 73.6842% (minimum 97%, Missing); duodenum: 61.4035% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 72.1649% (minimum 98%, Approved); hippocampal formation: 78.6517% (minimum 99%, Missing); hypothalamus: 76.9231% (minimum 99%, Missing); kidney: 76.0870% (minimum 99%, Missing); liver: 72.9167% (minimum 99%, Missing); lung: 69.3069% (minimum 99%, Missing); lymph node: 56.0000% (minimum 97%, Missing); midbrain: 78.6517% (minimum 99%, Missing); pancreas: 72.9167% (minimum 99%, Missing); parathyroid gland: 64.2202% (minimum 97%, Missing); pituitary gland: 72.9167% (minimum 99%, Missing); rectum: 69.3069% (minimum 97%, Missing); retina: 44.3038% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 50.3597% (minimum 99%, Missing); skin: 52.6316% (minimum 95%, Missing); small intestine: 67.3077% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 76.9231% (minimum 99%, Missing); spleen: 61.4035% (minimum 95%, Missing); stomach: 70.0000% (minimum 97%, Missing); thymus: 38.4615% (minimum 95%, Missing); thyroid gland: 70.7071% (minimum 95%, Missing); tongue: 55.5556% (minimum 97%, Missing); urinary bladder: 67.3077% (minimum 97%, Missing)",-0.565385,-0.414444,-0.546962,0,11,partial,8.8,5.6,11.2,"thymus: 11.2 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 2); lymph node: 5.5 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); stomach: 3 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181827,RFX7,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.4035% (minimum 75%, Missing); bone marrow: 52.6316% (minimum 75%, Missing); cerebellum: 56.0000% (minimum 75%, Missing); cerebral cortex: 61.9469% (minimum 75%, Missing); duodenum: 61.4035% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); liver: 72.9167% (minimum 75%, Missing); lung: 69.3069% (minimum 75%, Missing); lymph node: 56.0000% (minimum 70%, Missing); pancreas: 72.9167% (minimum 75%, Missing); parathyroid gland: 64.2202% (minimum 70%, Missing); pituitary gland: 72.9167% (minimum 75%, Missing); rectum: 69.3069% (minimum 70%, Missing); retina: 44.3038% (minimum 75%, Missing); skeletal muscle: 50.3597% (minimum 75%, Missing); skin: 52.6316% (minimum 65%, Missing); small intestine: 67.3077% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 61.4035% (minimum 65%, Missing); thymus: 38.4615% (minimum 65%, Missing); tongue: 55.5556% (minimum 70%, Missing); urinary bladder: 67.3077% (minimum 70%, Missing)",-0.265385,-0.144444,-0.306962,0,11,partial,8.8,5.6,11.2,"thymus: 11.2 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 2); lymph node: 5.5 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); stomach: 3 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181827,RFX7,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.4035% (minimum 75%, Missing); bone marrow: 52.6316% (minimum 75%, Missing); cerebellum: 56.0000% (minimum 75%, Missing); cerebral cortex: 61.9469% (minimum 75%, Missing); duodenum: 61.4035% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); liver: 72.9167% (minimum 75%, Missing); lung: 69.3069% (minimum 75%, Missing); lymph node: 56.0000% (minimum 70%, Missing); pancreas: 72.9167% (minimum 75%, Missing); parathyroid gland: 64.2202% (minimum 70%, Missing); pituitary gland: 72.9167% (minimum 75%, Missing); rectum: 69.3069% (minimum 70%, Missing); retina: 44.3038% (minimum 75%, Missing); skeletal muscle: 50.3597% (minimum 75%, Missing); skin: 52.6316% (minimum 65%, Missing); small intestine: 67.3077% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 61.4035% (minimum 65%, Missing); thymus: 38.4615% (minimum 65%, Missing); tongue: 55.5556% (minimum 70%, Missing); urinary bladder: 67.3077% (minimum 70%, Missing)",-0.265385,-0.144444,-0.306962,0,11,partial,8.8,5.6,11.2,"thymus: 11.2 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 3); lymph node: 5.5 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); small intestine: 3.4 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181827,RFX7,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.4035% (minimum 75%, Missing); bone marrow: 52.6316% (minimum 75%, Missing); cerebellum: 56.0000% (minimum 75%, Missing); cerebral cortex: 61.9469% (minimum 75%, Missing); duodenum: 61.4035% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); liver: 72.9167% (minimum 75%, Missing); lung: 69.3069% (minimum 75%, Missing); lymph node: 56.0000% (minimum 70%, Missing); pancreas: 72.9167% (minimum 75%, Missing); parathyroid gland: 64.2202% (minimum 70%, Missing); pituitary gland: 72.9167% (minimum 75%, Missing); rectum: 69.3069% (minimum 70%, Missing); retina: 44.3038% (minimum 75%, Missing); skeletal muscle: 50.3597% (minimum 75%, Missing); skin: 52.6316% (minimum 65%, Missing); small intestine: 67.3077% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 61.4035% (minimum 65%, Missing); thymus: 38.4615% (minimum 65%, Missing); tongue: 55.5556% (minimum 70%, Missing); urinary bladder: 67.3077% (minimum 70%, Missing)",-0.265385,-0.144444,-0.306962,0,11,partial,8.8,5.6,11.2,"thymus: 11.2 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 3); lymph node: 5.5 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); small intestine: 3.4 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181827,RFX7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.4035% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 52.6316% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.9469% (minimum 75%, Baseline (adaptation disabled)); duodenum: 61.4035% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 72.1649% (minimum 75%, Baseline (adaptation disabled)); liver: 72.9167% (minimum 75%, Baseline (adaptation disabled)); lung: 69.3069% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 72.9167% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.2202% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.9167% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.3069% (minimum 70%, Baseline (adaptation disabled)); retina: 44.3038% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 50.3597% (minimum 75%, Baseline (adaptation disabled)); skin: 52.6316% (minimum 65%, Baseline (adaptation disabled)); small intestine: 67.3077% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.4035% (minimum 65%, Baseline (adaptation disabled)); thymus: 38.4615% (minimum 65%, Baseline (adaptation disabled)); tongue: 55.5556% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.3077% (minimum 70%, Baseline (adaptation disabled))",-0.265385,-0.144444,-0.306962,0,11,partial,8.8,5.6,11.2,"thymus: 11.2 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 3); lymph node: 5.5 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); small intestine: 3.4 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181827,RFX7,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181867,FTMT,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181867,FTMT,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181867,FTMT,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181867,FTMT,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181867,FTMT,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6486% (minimum 90%, Approved); adrenal gland: 40.0000% (minimum 99%, Missing); amygdala: 60.0000% (minimum 99%, Missing); basal ganglia: 58.0645% (minimum 99%, Missing); bone marrow: 30.5085% (minimum 99%, Missing); cerebellum: 43.9024% (minimum 98%, Approved); cerebral cortex: 52.9412% (minimum 98%, Approved); choroid plexus: 54.5455% (minimum 99%, Missing); colon: 51.4286% (minimum 97%, Missing); duodenum: 52.9412% (minimum 98%, Approved); esophagus: 52.9412% (minimum 95%, Approved); heart muscle: 36.0000% (minimum 98%, Approved); hippocampal formation: 62.0690% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 48.6486% (minimum 99%, Missing); liver: 40.0000% (minimum 98%, Approved); lung: 48.6486% (minimum 99%, Missing); lymph node: 52.9412% (minimum 97%, Missing); midbrain: 62.0690% (minimum 99%, Missing); pancreas: 39.1304% (minimum 99%, Missing); parathyroid gland: 46.1538% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 58.0645% (minimum 97%, Missing); retina: 60.0000% (minimum 99%, Missing); salivary gland: 51.4286% (minimum 97%, Missing); skeletal muscle: 23.6842% (minimum 98%, Approved); skin: 38.2979% (minimum 95%, Missing); small intestine: 52.9412% (minimum 99%, Missing); smooth muscle: 52.9412% (minimum 98%, Approved); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 51.4286% (minimum 95%, Missing); stomach: 48.6486% (minimum 97%, Missing); thymus: 58.0645% (minimum 95%, Missing); thyroid gland: 58.0645% (minimum 90%, Approved); tongue: 32.1429% (minimum 97%, Missing); urinary bladder: 58.0645% (minimum 95%, Approved)",-0.567021,-0.648571,-0.743158,0,3,partial,5.8,3.8,2.9,"skeletal muscle: 5.8 nTPM (vital, limit 2); bone marrow: 4.1 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); heart muscle: 3.2 nTPM (vital, limit 2); pancreas: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 2); cerebellum: 2.3 nTPM (vital, limit 2); parathyroid gland: 2.1 nTPM (protected, limit 2); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181873,IBA57,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6486% (minimum 60%, Approved); adrenal gland: 40.0000% (minimum 75%, Missing); amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 58.0645% (minimum 75%, Missing); bone marrow: 30.5085% (minimum 75%, Missing); cerebellum: 43.9024% (minimum 70%, Approved); cerebral cortex: 52.9412% (minimum 70%, Approved); choroid plexus: 54.5455% (minimum 75%, Missing); colon: 51.4286% (minimum 70%, Missing); duodenum: 52.9412% (minimum 70%, Approved); esophagus: 52.9412% (minimum 65%, Approved); heart muscle: 36.0000% (minimum 70%, Approved); hippocampal formation: 62.0690% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 48.6486% (minimum 75%, Missing); liver: 40.0000% (minimum 70%, Approved); lung: 48.6486% (minimum 75%, Missing); lymph node: 52.9412% (minimum 70%, Missing); midbrain: 62.0690% (minimum 75%, Missing); pancreas: 39.1304% (minimum 75%, Missing); parathyroid gland: 46.1538% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 58.0645% (minimum 70%, Missing); retina: 60.0000% (minimum 75%, Missing); salivary gland: 51.4286% (minimum 70%, Missing); skeletal muscle: 23.6842% (minimum 70%, Approved); skin: 38.2979% (minimum 65%, Missing); small intestine: 52.9412% (minimum 75%, Missing); smooth muscle: 52.9412% (minimum 70%, Approved); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 51.4286% (minimum 65%, Missing); stomach: 48.6486% (minimum 70%, Missing); thymus: 58.0645% (minimum 65%, Missing); thyroid gland: 58.0645% (minimum 60%, Approved); tongue: 32.1429% (minimum 70%, Missing); urinary bladder: 58.0645% (minimum 65%, Approved)",-0.267021,-0.378571,-0.463158,0,3,partial,5.8,3.8,2.9,"skeletal muscle: 5.8 nTPM (vital, limit 2); bone marrow: 4.1 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); heart muscle: 3.2 nTPM (vital, limit 2); pancreas: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 2); cerebellum: 2.3 nTPM (vital, limit 2); parathyroid gland: 2.1 nTPM (protected, limit 2); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181873,IBA57,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6486% (minimum 60%, Approved); adrenal gland: 40.0000% (minimum 75%, Missing); amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 58.0645% (minimum 75%, Missing); bone marrow: 30.5085% (minimum 75%, Missing); cerebellum: 43.9024% (minimum 70%, Approved); cerebral cortex: 52.9412% (minimum 70%, Approved); choroid plexus: 54.5455% (minimum 75%, Missing); colon: 51.4286% (minimum 70%, Missing); duodenum: 52.9412% (minimum 70%, Approved); esophagus: 52.9412% (minimum 65%, Approved); heart muscle: 36.0000% (minimum 70%, Approved); hippocampal formation: 62.0690% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 48.6486% (minimum 75%, Missing); liver: 40.0000% (minimum 70%, Approved); lung: 48.6486% (minimum 75%, Missing); lymph node: 52.9412% (minimum 70%, Missing); midbrain: 62.0690% (minimum 75%, Missing); pancreas: 39.1304% (minimum 75%, Missing); parathyroid gland: 46.1538% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 58.0645% (minimum 70%, Missing); retina: 60.0000% (minimum 75%, Missing); salivary gland: 51.4286% (minimum 70%, Missing); skeletal muscle: 23.6842% (minimum 70%, Approved); skin: 38.2979% (minimum 65%, Missing); small intestine: 52.9412% (minimum 75%, Missing); smooth muscle: 52.9412% (minimum 70%, Approved); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 51.4286% (minimum 65%, Missing); stomach: 48.6486% (minimum 70%, Missing); thymus: 58.0645% (minimum 65%, Missing); thyroid gland: 58.0645% (minimum 60%, Approved); tongue: 32.1429% (minimum 70%, Missing); urinary bladder: 58.0645% (minimum 65%, Approved)",-0.267021,-0.378571,-0.463158,0,3,partial,5.8,3.8,2.9,"skeletal muscle: 5.8 nTPM (vital, limit 2); bone marrow: 4.1 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); heart muscle: 3.2 nTPM (vital, limit 2); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2); lung: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181873,IBA57,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6486% (minimum 60%, Approved); adrenal gland: 40.0000% (minimum 75%, Missing); amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 58.0645% (minimum 75%, Missing); bone marrow: 30.5085% (minimum 75%, Missing); cerebellum: 43.9024% (minimum 70%, Approved); cerebral cortex: 52.9412% (minimum 70%, Approved); choroid plexus: 54.5455% (minimum 75%, Missing); colon: 51.4286% (minimum 70%, Missing); duodenum: 52.9412% (minimum 70%, Approved); esophagus: 52.9412% (minimum 65%, Approved); heart muscle: 36.0000% (minimum 70%, Approved); hippocampal formation: 62.0690% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 48.6486% (minimum 75%, Missing); liver: 40.0000% (minimum 70%, Approved); lung: 48.6486% (minimum 75%, Missing); lymph node: 52.9412% (minimum 70%, Missing); midbrain: 62.0690% (minimum 75%, Missing); pancreas: 39.1304% (minimum 75%, Missing); parathyroid gland: 46.1538% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 58.0645% (minimum 70%, Missing); retina: 60.0000% (minimum 75%, Missing); salivary gland: 51.4286% (minimum 70%, Missing); skeletal muscle: 23.6842% (minimum 70%, Approved); skin: 38.2979% (minimum 65%, Missing); small intestine: 52.9412% (minimum 75%, Missing); smooth muscle: 52.9412% (minimum 70%, Approved); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 51.4286% (minimum 65%, Missing); stomach: 48.6486% (minimum 70%, Missing); thymus: 58.0645% (minimum 65%, Missing); thyroid gland: 58.0645% (minimum 60%, Approved); tongue: 32.1429% (minimum 70%, Missing); urinary bladder: 58.0645% (minimum 65%, Approved)",-0.267021,-0.378571,-0.463158,0,3,partial,5.8,3.8,2.9,"skeletal muscle: 5.8 nTPM (vital, limit 2); bone marrow: 4.1 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); heart muscle: 3.2 nTPM (vital, limit 2); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2); lung: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181873,IBA57,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6486% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 40.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 60.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.0645% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 30.5085% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.9024% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 52.9412% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 54.5455% (minimum 75%, Baseline (adaptation disabled)); colon: 51.4286% (minimum 70%, Baseline (adaptation disabled)); duodenum: 52.9412% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.9412% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 36.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 62.0690% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.6486% (minimum 75%, Baseline (adaptation disabled)); liver: 40.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 48.6486% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.9412% (minimum 70%, Baseline (adaptation disabled)); midbrain: 62.0690% (minimum 75%, Baseline (adaptation disabled)); pancreas: 39.1304% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 46.1538% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.0645% (minimum 70%, Baseline (adaptation disabled)); retina: 60.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.4286% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 23.6842% (minimum 75%, Baseline (adaptation disabled)); skin: 38.2979% (minimum 65%, Baseline (adaptation disabled)); small intestine: 52.9412% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 52.9412% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 51.4286% (minimum 65%, Baseline (adaptation disabled)); stomach: 48.6486% (minimum 70%, Baseline (adaptation disabled)); thymus: 58.0645% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.0645% (minimum 65%, Baseline (adaptation disabled)); tongue: 32.1429% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.0645% (minimum 70%, Baseline (adaptation disabled))",-0.267021,-0.378571,-0.513158,0,3,partial,5.8,3.8,2.9,"skeletal muscle: 5.8 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); heart muscle: 3.2 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181873,IBA57,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.8657% (minimum 95%, Missing); adrenal gland: 83.7398% (minimum 99%, Missing); amygdala: 80.4688% (minimum 99%, Missing); basal ganglia: 81.1024% (minimum 99%, Missing); bone marrow: 43.4599% (minimum 99%, Missing); cerebellum: 81.7460% (minimum 99%, Missing); cerebral cortex: 79.8450% (minimum 99%, Missing); choroid plexus: 77.4436% (minimum 99%, Missing); colon: 69.1275% (minimum 97%, Missing); duodenum: 76.8657% (minimum 99%, Missing); esophagus: 60.5882% (minimum 97%, Missing); heart muscle: 83.0645% (minimum 99%, Missing); hippocampal formation: 77.4436% (minimum 99%, Missing); hypothalamus: 81.1024% (minimum 99%, Missing); kidney: 72.0280% (minimum 99%, Missing); liver: 77.4436% (minimum 99%, Missing); lung: 75.7353% (minimum 99%, Missing); lymph node: 27.7628% (minimum 97%, Missing); midbrain: 79.8450% (minimum 99%, Missing); pancreas: 81.7460% (minimum 99%, Missing); parathyroid gland: 84.4262% (minimum 97%, Missing); pituitary gland: 85.1240% (minimum 99%, Missing); rectum: 70.0680% (minimum 97%, Missing); retina: 71.5278% (minimum 99%, Missing); salivary gland: 77.4436% (minimum 97%, Missing); skeletal muscle: 85.8333% (minimum 99%, Missing); skin: 74.1007% (minimum 95%, Missing); small intestine: 56.5934% (minimum 99%, Missing); smooth muscle: 83.7398% (minimum 99%, Missing); spinal cord: 79.2308% (minimum 99%, Missing); spleen: 49.0476% (minimum 95%, Missing); stomach: 70.0680% (minimum 97%, Missing); thymus: 29.5129% (minimum 95%, Missing); thyroid gland: 77.4436% (minimum 95%, Missing); tongue: 88.7931% (minimum 97%, Missing); urinary bladder: 65.6051% (minimum 97%, Missing)",-0.654871,-0.692372,-0.555401,0,80,unavailable,13.4,26.8,24.6,"lymph node: 26.8 nTPM (protected, limit 2); thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181896,ZNF101,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 43.4599% (minimum 75%, Missing); colon: 69.1275% (minimum 70%, Missing); esophagus: 60.5882% (minimum 70%, Missing); kidney: 72.0280% (minimum 75%, Missing); lymph node: 27.7628% (minimum 70%, Missing); retina: 71.5278% (minimum 75%, Missing); small intestine: 56.5934% (minimum 75%, Missing); spleen: 49.0476% (minimum 65%, Missing); thymus: 29.5129% (minimum 65%, Missing); urinary bladder: 65.6051% (minimum 70%, Missing)",-0.354871,-0.422372,-0.315401,0,80,unavailable,13.4,26.8,24.6,"lymph node: 26.8 nTPM (protected, limit 2); thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181896,ZNF101,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 43.4599% (minimum 75%, Missing); colon: 69.1275% (minimum 70%, Missing); esophagus: 60.5882% (minimum 70%, Missing); kidney: 72.0280% (minimum 75%, Missing); lymph node: 27.7628% (minimum 70%, Missing); retina: 71.5278% (minimum 75%, Missing); small intestine: 56.5934% (minimum 75%, Missing); spleen: 49.0476% (minimum 65%, Missing); thymus: 29.5129% (minimum 65%, Missing); urinary bladder: 65.6051% (minimum 70%, Missing)",-0.354871,-0.422372,-0.315401,0,80,unavailable,13.4,26.8,24.6,"lymph node: 26.8 nTPM (protected, limit 3); thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181896,ZNF101,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 43.4599% (minimum 75%, Missing); colon: 69.1275% (minimum 70%, Missing); esophagus: 60.5882% (minimum 70%, Missing); kidney: 72.0280% (minimum 75%, Missing); lymph node: 27.7628% (minimum 70%, Missing); retina: 71.5278% (minimum 75%, Missing); small intestine: 56.5934% (minimum 75%, Missing); spleen: 49.0476% (minimum 65%, Missing); thymus: 29.5129% (minimum 65%, Missing); urinary bladder: 65.6051% (minimum 70%, Missing)",-0.354871,-0.422372,-0.315401,0,80,unavailable,13.4,26.8,24.6,"lymph node: 26.8 nTPM (protected, limit 3); thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181896,ZNF101,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 43.4599% (minimum 75%, Baseline (adaptation disabled)); colon: 69.1275% (minimum 70%, Baseline (adaptation disabled)); esophagus: 60.5882% (minimum 70%, Baseline (adaptation disabled)); kidney: 72.0280% (minimum 75%, Baseline (adaptation disabled)); lymph node: 27.7628% (minimum 70%, Baseline (adaptation disabled)); retina: 71.5278% (minimum 75%, Baseline (adaptation disabled)); small intestine: 56.5934% (minimum 75%, Baseline (adaptation disabled)); spleen: 49.0476% (minimum 65%, Baseline (adaptation disabled)); thymus: 29.5129% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 65.6051% (minimum 70%, Baseline (adaptation disabled))",-0.354871,-0.422372,-0.315401,0,80,unavailable,13.4,26.8,24.6,"lymph node: 26.8 nTPM (protected, limit 3); thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181896,ZNF101,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7758% (minimum 90%, Approved); adrenal gland: 52.8195% (minimum 99%, Missing); amygdala: 59.5339% (minimum 99%, Missing); basal ganglia: 55.7540% (minimum 99%, Missing); bone marrow: 53.2197% (minimum 99%, Missing); cerebellum: 43.9750% (minimum 99%, Missing); cerebral cortex: 53.2197% (minimum 99%, Missing); choroid plexus: 79.3785% (minimum 99%, Missing); colon: 57.8189% (minimum 97%, Missing); duodenum: 56.6532% (minimum 99%, Missing); esophagus: 58.0579% (minimum 97%, Missing); heart muscle: 59.9147% (minimum 99%, Missing); hippocampal formation: 58.0579% (minimum 99%, Missing); hypothalamus: 58.9099% (minimum 99%, Missing); kidney: 41.5066% (minimum 99%, Missing); liver: 40.1429% (minimum 99%, Missing); lung: 55.8648% (minimum 99%, Missing); lymph node: 63.8636% (minimum 97%, Missing); midbrain: 60.8225% (minimum 99%, Missing); pancreas: 68.7042% (minimum 99%, Missing); parathyroid gland: 52.0370% (minimum 97%, Missing); pituitary gland: 65.1972% (minimum 99%, Missing); rectum: 61.2200% (minimum 97%, Missing); retina: 60.0427% (minimum 99%, Missing); salivary gland: 61.2200% (minimum 97%, Missing); skeletal muscle: 57.5820% (minimum 99%, Missing); skin: 60.1713% (minimum 95%, Missing); small intestine: 62.7232% (minimum 99%, Missing); smooth muscle: 52.2305% (minimum 99%, Missing); spinal cord: 50.0891% (minimum 99%, Missing); spleen: 63.4312% (minimum 95%, Missing); stomach: 64.1553% (minimum 97%, Missing); thymus: 65.8080% (minimum 95%, Missing); thyroid gland: 49.2982% (minimum 95%, Missing); tongue: 52.3277% (minimum 97%, Missing); urinary bladder: 56.7677% (minimum 97%, Missing)",-0.457018,-0.44963,-0.588571,0,3,partial,41.9,25.9,28.9,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (manageable, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 2); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 2); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (manageable, limit 10); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 2); skeletal muscle: 20.7 nTPM (vital, limit 1); colon: 20.5 nTPM (protected, limit 2); hippocampal formation: 20.3 nTPM (vital, limit 1); esophagus: 20.3 nTPM (protected, limit 2); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); skin: 18.6 nTPM (manageable, limit 5); midbrain: 18.1 nTPM (vital, limit 1); salivary gland: 17.8 nTPM (protected, limit 2); rectum: 17.8 nTPM (protected, limit 2); small intestine: 16.7 nTPM (vital, limit 1); spleen: 16.2 nTPM (manageable, limit 5); lymph node: 15.9 nTPM (protected, limit 2); stomach: 15.7 nTPM (protected, limit 2); pituitary gland: 15 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181904,C5orf24,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7758% (minimum 60%, Approved); adrenal gland: 52.8195% (minimum 75%, Missing); amygdala: 59.5339% (minimum 75%, Missing); basal ganglia: 55.7540% (minimum 75%, Missing); bone marrow: 53.2197% (minimum 75%, Missing); cerebellum: 43.9750% (minimum 75%, Missing); cerebral cortex: 53.2197% (minimum 75%, Missing); colon: 57.8189% (minimum 70%, Missing); duodenum: 56.6532% (minimum 75%, Missing); esophagus: 58.0579% (minimum 70%, Missing); heart muscle: 59.9147% (minimum 75%, Missing); hippocampal formation: 58.0579% (minimum 75%, Missing); hypothalamus: 58.9099% (minimum 75%, Missing); kidney: 41.5066% (minimum 75%, Missing); liver: 40.1429% (minimum 75%, Missing); lung: 55.8648% (minimum 75%, Missing); lymph node: 63.8636% (minimum 70%, Missing); midbrain: 60.8225% (minimum 75%, Missing); pancreas: 68.7042% (minimum 75%, Missing); parathyroid gland: 52.0370% (minimum 70%, Missing); pituitary gland: 65.1972% (minimum 75%, Missing); rectum: 61.2200% (minimum 70%, Missing); retina: 60.0427% (minimum 75%, Missing); salivary gland: 61.2200% (minimum 70%, Missing); skeletal muscle: 57.5820% (minimum 75%, Missing); skin: 60.1713% (minimum 65%, Missing); small intestine: 62.7232% (minimum 75%, Missing); smooth muscle: 52.2305% (minimum 75%, Missing); spinal cord: 50.0891% (minimum 75%, Missing); spleen: 63.4312% (minimum 65%, Missing); stomach: 64.1553% (minimum 70%, Missing); thyroid gland: 49.2982% (minimum 65%, Missing); tongue: 52.3277% (minimum 70%, Missing); urinary bladder: 56.7677% (minimum 70%, Missing)",-0.157018,-0.17963,-0.348571,0,3,partial,41.9,25.9,28.9,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (manageable, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 2); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 2); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (manageable, limit 10); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 2); skeletal muscle: 20.7 nTPM (vital, limit 1); colon: 20.5 nTPM (protected, limit 2); hippocampal formation: 20.3 nTPM (vital, limit 1); esophagus: 20.3 nTPM (protected, limit 2); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); skin: 18.6 nTPM (manageable, limit 5); midbrain: 18.1 nTPM (vital, limit 1); salivary gland: 17.8 nTPM (protected, limit 2); rectum: 17.8 nTPM (protected, limit 2); small intestine: 16.7 nTPM (vital, limit 1); spleen: 16.2 nTPM (manageable, limit 5); lymph node: 15.9 nTPM (protected, limit 2); stomach: 15.7 nTPM (protected, limit 2); pituitary gland: 15 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181904,C5orf24,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7758% (minimum 60%, Approved); adrenal gland: 52.8195% (minimum 75%, Missing); amygdala: 59.5339% (minimum 75%, Missing); basal ganglia: 55.7540% (minimum 75%, Missing); bone marrow: 53.2197% (minimum 75%, Missing); cerebellum: 43.9750% (minimum 75%, Missing); cerebral cortex: 53.2197% (minimum 75%, Missing); colon: 57.8189% (minimum 70%, Missing); duodenum: 56.6532% (minimum 75%, Missing); esophagus: 58.0579% (minimum 70%, Missing); heart muscle: 59.9147% (minimum 75%, Missing); hippocampal formation: 58.0579% (minimum 75%, Missing); hypothalamus: 58.9099% (minimum 75%, Missing); kidney: 41.5066% (minimum 75%, Missing); liver: 40.1429% (minimum 75%, Missing); lung: 55.8648% (minimum 75%, Missing); lymph node: 63.8636% (minimum 70%, Missing); midbrain: 60.8225% (minimum 75%, Missing); pancreas: 68.7042% (minimum 75%, Missing); parathyroid gland: 52.0370% (minimum 70%, Missing); pituitary gland: 65.1972% (minimum 75%, Missing); rectum: 61.2200% (minimum 70%, Missing); retina: 60.0427% (minimum 75%, Missing); salivary gland: 61.2200% (minimum 70%, Missing); skeletal muscle: 57.5820% (minimum 75%, Missing); skin: 60.1713% (minimum 65%, Missing); small intestine: 62.7232% (minimum 75%, Missing); smooth muscle: 52.2305% (minimum 75%, Missing); spinal cord: 50.0891% (minimum 75%, Missing); spleen: 63.4312% (minimum 65%, Missing); stomach: 64.1553% (minimum 70%, Missing); thyroid gland: 49.2982% (minimum 65%, Missing); tongue: 52.3277% (minimum 70%, Missing); urinary bladder: 56.7677% (minimum 70%, Missing)",-0.157018,-0.17963,-0.348571,0,3,partial,41.9,25.9,28.9,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (manageable, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 3); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 3); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (manageable, limit 10); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 3); skeletal muscle: 20.7 nTPM (vital, limit 1); colon: 20.5 nTPM (protected, limit 3); hippocampal formation: 20.3 nTPM (vital, limit 1); esophagus: 20.3 nTPM (protected, limit 3); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); skin: 18.6 nTPM (manageable, limit 5); midbrain: 18.1 nTPM (vital, limit 1); salivary gland: 17.8 nTPM (protected, limit 3); rectum: 17.8 nTPM (protected, limit 3); small intestine: 16.7 nTPM (vital, limit 1); spleen: 16.2 nTPM (manageable, limit 5); lymph node: 15.9 nTPM (protected, limit 3); stomach: 15.7 nTPM (protected, limit 3); pituitary gland: 15 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181904,C5orf24,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7758% (minimum 60%, Approved); adrenal gland: 52.8195% (minimum 75%, Missing); amygdala: 59.5339% (minimum 75%, Missing); basal ganglia: 55.7540% (minimum 75%, Missing); bone marrow: 53.2197% (minimum 75%, Missing); cerebellum: 43.9750% (minimum 75%, Missing); cerebral cortex: 53.2197% (minimum 75%, Missing); colon: 57.8189% (minimum 70%, Missing); duodenum: 56.6532% (minimum 75%, Missing); esophagus: 58.0579% (minimum 70%, Missing); heart muscle: 59.9147% (minimum 75%, Missing); hippocampal formation: 58.0579% (minimum 75%, Missing); hypothalamus: 58.9099% (minimum 75%, Missing); kidney: 41.5066% (minimum 75%, Missing); liver: 40.1429% (minimum 75%, Missing); lung: 55.8648% (minimum 75%, Missing); lymph node: 63.8636% (minimum 70%, Missing); midbrain: 60.8225% (minimum 75%, Missing); pancreas: 68.7042% (minimum 75%, Missing); parathyroid gland: 52.0370% (minimum 70%, Missing); pituitary gland: 65.1972% (minimum 75%, Missing); rectum: 61.2200% (minimum 70%, Missing); retina: 60.0427% (minimum 75%, Missing); salivary gland: 61.2200% (minimum 70%, Missing); skeletal muscle: 57.5820% (minimum 75%, Missing); skin: 60.1713% (minimum 65%, Missing); small intestine: 62.7232% (minimum 75%, Missing); smooth muscle: 52.2305% (minimum 75%, Missing); spinal cord: 50.0891% (minimum 75%, Missing); spleen: 63.4312% (minimum 65%, Missing); stomach: 64.1553% (minimum 70%, Missing); thyroid gland: 49.2982% (minimum 65%, Missing); tongue: 52.3277% (minimum 70%, Missing); urinary bladder: 56.7677% (minimum 70%, Missing)",-0.157018,-0.17963,-0.348571,0,3,partial,41.9,25.9,28.9,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (manageable, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 3); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 3); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (manageable, limit 10); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 3); skeletal muscle: 20.7 nTPM (vital, limit 1); colon: 20.5 nTPM (protected, limit 3); hippocampal formation: 20.3 nTPM (vital, limit 1); esophagus: 20.3 nTPM (protected, limit 3); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); skin: 18.6 nTPM (manageable, limit 5); midbrain: 18.1 nTPM (vital, limit 1); salivary gland: 17.8 nTPM (protected, limit 3); rectum: 17.8 nTPM (protected, limit 3); small intestine: 16.7 nTPM (vital, limit 1); spleen: 16.2 nTPM (manageable, limit 5); lymph node: 15.9 nTPM (protected, limit 3); stomach: 15.7 nTPM (protected, limit 3); pituitary gland: 15 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181904,C5orf24,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7758% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 52.8195% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.5339% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.7540% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 53.2197% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.9750% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.2197% (minimum 75%, Baseline (adaptation disabled)); colon: 57.8189% (minimum 70%, Baseline (adaptation disabled)); duodenum: 56.6532% (minimum 75%, Baseline (adaptation disabled)); esophagus: 58.0579% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.9147% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.0579% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.9099% (minimum 75%, Baseline (adaptation disabled)); kidney: 41.5066% (minimum 75%, Baseline (adaptation disabled)); liver: 40.1429% (minimum 75%, Baseline (adaptation disabled)); lung: 55.8648% (minimum 75%, Baseline (adaptation disabled)); lymph node: 63.8636% (minimum 70%, Baseline (adaptation disabled)); midbrain: 60.8225% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.7042% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.0370% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 65.1972% (minimum 75%, Baseline (adaptation disabled)); rectum: 61.2200% (minimum 70%, Baseline (adaptation disabled)); retina: 60.0427% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.2200% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 57.5820% (minimum 75%, Baseline (adaptation disabled)); skin: 60.1713% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.7232% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 52.2305% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.0891% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.4312% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.1553% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 49.2982% (minimum 65%, Baseline (adaptation disabled)); tongue: 52.3277% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.7677% (minimum 70%, Baseline (adaptation disabled))",-0.157018,-0.17963,-0.348571,0,3,partial,41.9,25.9,28.9,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (manageable, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 3); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 3); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (manageable, limit 5); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 3); skeletal muscle: 20.7 nTPM (vital, limit 1); colon: 20.5 nTPM (protected, limit 3); hippocampal formation: 20.3 nTPM (vital, limit 1); esophagus: 20.3 nTPM (protected, limit 3); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); skin: 18.6 nTPM (manageable, limit 5); midbrain: 18.1 nTPM (vital, limit 1); salivary gland: 17.8 nTPM (protected, limit 3); rectum: 17.8 nTPM (protected, limit 3); small intestine: 16.7 nTPM (vital, limit 1); spleen: 16.2 nTPM (manageable, limit 5); lymph node: 15.9 nTPM (protected, limit 3); stomach: 15.7 nTPM (protected, limit 3); pituitary gland: 15 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181904,C5orf24,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000181961,OR4A16,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000181961,OR4A16,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000181961,OR4A16,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000181961,OR4A16,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000181961,OR4A16,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181965,NEUROG1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181965,NEUROG1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181965,NEUROG1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181965,NEUROG1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000181965,NEUROG1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0311321,0.03,0.00426386,0,80,unavailable,0.3,0,1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182035,ADIG,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.331132,0.3,0.244264,0,80,unavailable,0.3,0,1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182035,ADIG,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.331132,0.3,0.244264,0,80,unavailable,0.3,0,1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182035,ADIG,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.331132,0.3,0.244264,0,80,unavailable,0.3,0,1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182035,ADIG,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.331132,0.3,0.244264,0,80,unavailable,0.3,0,1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182035,ADIG,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 82.1429% (minimum 98%, Approved); amygdala: 63.0137% (minimum 99%, Missing); basal ganglia: 51.1111% (minimum 99%, Missing); cerebellum: 86.7925% (minimum 98%, Approved); cerebral cortex: 56.7901% (minimum 98%, Approved); colon: 92.0000% (minimum 97%, Missing); heart muscle: 74.1935% (minimum 99%, Missing); hippocampal formation: 73.0159% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 97.8723% (minimum 99%, Missing); liver: 97.8723% (minimum 98%, Approved); lung: 97.8723% (minimum 98%, Approved); midbrain: 69.6970% (minimum 99%, Missing); pancreas: 97.8723% (minimum 98%, Approved); pituitary gland: 59.7403% (minimum 99%, Missing); retina: 92.0000% (minimum 99%, Missing); small intestine: 97.8723% (minimum 99%, Missing); smooth muscle: 97.8723% (minimum 98%, Approved); spinal cord: 85.1852% (minimum 99%, Missing); thyroid gland: 44.2308% (minimum 90%, Approved)",-0.457692,-0.05,-0.478889,0,4,partial,4.4,0.4,5.8,"basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182050,MGAT4C,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 63.0137% (minimum 75%, Missing); basal ganglia: 51.1111% (minimum 75%, Missing); cerebral cortex: 56.7901% (minimum 70%, Approved); heart muscle: 74.1935% (minimum 75%, Missing); hippocampal formation: 73.0159% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); midbrain: 69.6970% (minimum 75%, Missing); pituitary gland: 59.7403% (minimum 75%, Missing); thyroid gland: 44.2308% (minimum 60%, Approved)",-0.157692,0.22,-0.238889,0,4,partial,4.4,0.4,5.8,"basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182050,MGAT4C,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 63.0137% (minimum 75%, Missing); basal ganglia: 51.1111% (minimum 75%, Missing); cerebral cortex: 56.7901% (minimum 70%, Approved); heart muscle: 74.1935% (minimum 75%, Missing); hippocampal formation: 73.0159% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); midbrain: 69.6970% (minimum 75%, Missing); pituitary gland: 59.7403% (minimum 75%, Missing); thyroid gland: 44.2308% (minimum 60%, Approved)",-0.157692,0.22,-0.238889,0,4,partial,4.4,0.4,5.8,"basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182050,MGAT4C,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 63.0137% (minimum 75%, Missing); basal ganglia: 51.1111% (minimum 75%, Missing); cerebral cortex: 56.7901% (minimum 70%, Approved); heart muscle: 74.1935% (minimum 75%, Missing); hippocampal formation: 73.0159% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); midbrain: 69.6970% (minimum 75%, Missing); pituitary gland: 59.7403% (minimum 75%, Missing); thyroid gland: 44.2308% (minimum 60%, Approved)",-0.157692,0.22,-0.238889,0,4,partial,4.4,0.4,5.8,"basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182050,MGAT4C,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 63.0137% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 51.1111% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.7901% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 74.1935% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.0159% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); midbrain: 69.6970% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 59.7403% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 44.2308% (minimum 65%, Baseline (adaptation disabled))",-0.207692,0.22,-0.238889,0,4,partial,4.4,0.4,5.8,"thyroid gland: 5.8 nTPM (manageable, limit 5); basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182050,MGAT4C,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182053,TRIM49B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182053,TRIM49B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182053,TRIM49B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182053,TRIM49B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182053,TRIM49B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 57.1429% (minimum 99%, Missing)",0.05,0.03,-0.418571,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182083,OR6B2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 57.1429% (minimum 75%, Missing)",0.35,0.3,-0.178571,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182083,OR6B2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 57.1429% (minimum 75%, Missing)",0.35,0.3,-0.178571,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182083,OR6B2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 57.1429% (minimum 75%, Missing)",0.35,0.3,-0.178571,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182083,OR6B2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 57.1429% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.178571,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182083,OR6B2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 80.0000% (minimum 99%, Missing)",0.05,0.03,-0.19,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182111,ZNF716,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.05,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182111,ZNF716,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.05,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182111,ZNF716,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.05,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182111,ZNF716,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.05,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182111,ZNF716,current_fixed,True,False,True,False,10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.9582% (minimum 95%, Missing); adrenal gland: 87.7551% (minimum 99%, Missing); amygdala: 78.7546% (minimum 99%, Missing); basal ganglia: 79.6296% (minimum 99%, Missing); bone marrow: 93.8865% (minimum 99%, Missing); cerebellum: 62.1387% (minimum 99%, Missing); cerebral cortex: 74.1379% (minimum 99%, Missing); choroid plexus: 88.4774% (minimum 99%, Missing); colon: 87.3984% (minimum 97%, Missing); duodenum: 90.7173% (minimum 99%, Missing); esophagus: 92.6724% (minimum 95%, Approved); heart muscle: 86.3454% (minimum 99%, Missing); hippocampal formation: 78.4672% (minimum 99%, Missing); hypothalamus: 74.9129% (minimum 99%, Missing); kidney: 84.6457% (minimum 99%, Missing); liver: 86.0000% (minimum 99%, Missing); lung: 83.6576% (minimum 99%, Missing); lymph node: 78.7546% (minimum 97%, Missing); midbrain: 76.5125% (minimum 99%, Missing); pancreas: 88.1148% (minimum 99%, Missing); parathyroid gland: 42.4901% (minimum 97%, Missing); pituitary gland: 82.6923% (minimum 99%, Missing); rectum: 84.6457% (minimum 97%, Missing); retina: 69.8052% (minimum 99%, Missing); salivary gland: 75.9717% (minimum 97%, Missing); skeletal muscle: 83.9844% (minimum 99%, Missing); skin: 90.7173% (minimum 95%, Missing); small intestine: 91.1017% (minimum 99%, Missing); smooth muscle: 88.8430% (minimum 99%, Missing); spinal cord: 76.5125% (minimum 99%, Missing); spleen: 77.8986% (minimum 95%, Missing); stomach: 88.4774% (minimum 97%, Missing); thymus: 68.6901% (minimum 95%, Missing); thyroid gland: 75.1748% (minimum 95%, Missing); tongue: 82.0611% (minimum 97%, Missing); urinary bladder: 89.5833% (minimum 97%, Missing)",-0.263099,-0.545099,-0.368613,0,3,partial,13.1,29.1,9.8,"parathyroid gland: 29.1 nTPM (protected, limit 2); cerebellum: 13.1 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 2); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); hippocampal formation: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); amygdala: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182134,TDRKH,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 62.1387% (minimum 75%, Missing); cerebral cortex: 74.1379% (minimum 75%, Missing); hypothalamus: 74.9129% (minimum 75%, Missing); parathyroid gland: 42.4901% (minimum 70%, Missing); retina: 69.8052% (minimum 75%, Missing)",0.036901,-0.275099,-0.128613,0,3,partial,13.1,29.1,9.8,"parathyroid gland: 29.1 nTPM (protected, limit 2); cerebellum: 13.1 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 2); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); hippocampal formation: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); amygdala: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182134,TDRKH,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 62.1387% (minimum 75%, Missing); cerebral cortex: 74.1379% (minimum 75%, Missing); hypothalamus: 74.9129% (minimum 75%, Missing); parathyroid gland: 42.4901% (minimum 70%, Missing); retina: 69.8052% (minimum 75%, Missing)",0.036901,-0.275099,-0.128613,0,3,partial,13.1,29.1,9.8,"parathyroid gland: 29.1 nTPM (protected, limit 3); cerebellum: 13.1 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 3); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); hippocampal formation: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 3); amygdala: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182134,TDRKH,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 62.1387% (minimum 75%, Missing); cerebral cortex: 74.1379% (minimum 75%, Missing); hypothalamus: 74.9129% (minimum 75%, Missing); parathyroid gland: 42.4901% (minimum 70%, Missing); retina: 69.8052% (minimum 75%, Missing)",0.036901,-0.275099,-0.128613,0,3,partial,13.1,29.1,9.8,"parathyroid gland: 29.1 nTPM (protected, limit 3); cerebellum: 13.1 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 3); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); hippocampal formation: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 3); amygdala: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182134,TDRKH,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 62.1387% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.1379% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.9129% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 42.4901% (minimum 70%, Baseline (adaptation disabled)); retina: 69.8052% (minimum 75%, Baseline (adaptation disabled))",0.036901,-0.275099,-0.128613,0,3,partial,13.1,29.1,9.8,"parathyroid gland: 29.1 nTPM (protected, limit 3); cerebellum: 13.1 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 3); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); hippocampal formation: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 3); amygdala: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182134,TDRKH,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182170,MRGPRG,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182170,MRGPRG,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182170,MRGPRG,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182170,MRGPRG,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182170,MRGPRG,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.3590% (minimum 95%, Missing); adrenal gland: 79.8165% (minimum 99%, Missing); amygdala: 82.0755% (minimum 99%, Missing); basal ganglia: 82.8571% (minimum 99%, Missing); bone marrow: 54.3750% (minimum 99%, Missing); cerebellum: 93.5484% (minimum 99%, Missing); cerebral cortex: 80.5556% (minimum 99%, Missing); choroid plexus: 75.6522% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 88.7755% (minimum 99%, Missing); esophagus: 70.7317% (minimum 97%, Missing); heart muscle: 84.4660% (minimum 99%, Missing); hippocampal formation: 82.8571% (minimum 99%, Missing); hypothalamus: 85.2941% (minimum 99%, Missing); kidney: 76.9912% (minimum 99%, Missing); liver: 80.5556% (minimum 99%, Missing); lung: 76.9912% (minimum 99%, Missing); lymph node: 64.9254% (minimum 97%, Missing); midbrain: 79.8165% (minimum 99%, Missing); pancreas: 80.5556% (minimum 99%, Missing); parathyroid gland: 64.9254% (minimum 97%, Missing); pituitary gland: 81.3084% (minimum 99%, Missing); rectum: 77.6786% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); salivary gland: 40.6542% (minimum 97%, Missing); skeletal muscle: 87.8788% (minimum 99%, Missing); skin: 68.5039% (minimum 95%, Missing); small intestine: 78.3784% (minimum 99%, Missing); smooth muscle: 67.4419% (minimum 99%, Missing); spinal cord: 71.9008% (minimum 99%, Missing); spleen: 76.9912% (minimum 95%, Missing); stomach: 77.6786% (minimum 97%, Missing); thymus: 60.0000% (minimum 95%, Missing); thyroid gland: 78.3784% (minimum 95%, Missing); tongue: 87.8788% (minimum 97%, Missing); urinary bladder: 71.3115% (minimum 97%, Missing)",-0.35,-0.563458,-0.44625,0,7,partial,7.3,12.7,5.8,"salivary gland: 12.7 nTPM (protected, limit 2); bone marrow: 7.3 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); esophagus: 3.6 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); spinal cord: 3.4 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182185,RAD51B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.3750% (minimum 75%, Missing); lymph node: 64.9254% (minimum 70%, Missing); parathyroid gland: 64.9254% (minimum 70%, Missing); salivary gland: 40.6542% (minimum 70%, Missing); smooth muscle: 67.4419% (minimum 75%, Missing); spinal cord: 71.9008% (minimum 75%, Missing); thymus: 60.0000% (minimum 65%, Missing)",-0.05,-0.293458,-0.20625,0,7,partial,7.3,12.7,5.8,"salivary gland: 12.7 nTPM (protected, limit 2); bone marrow: 7.3 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); esophagus: 3.6 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); spinal cord: 3.4 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182185,RAD51B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.3750% (minimum 75%, Missing); lymph node: 64.9254% (minimum 70%, Missing); parathyroid gland: 64.9254% (minimum 70%, Missing); salivary gland: 40.6542% (minimum 70%, Missing); smooth muscle: 67.4419% (minimum 75%, Missing); spinal cord: 71.9008% (minimum 75%, Missing); thymus: 60.0000% (minimum 65%, Missing)",-0.05,-0.293458,-0.20625,0,7,partial,7.3,12.7,5.8,"salivary gland: 12.7 nTPM (protected, limit 3); bone marrow: 7.3 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 3); parathyroid gland: 4.7 nTPM (protected, limit 3); smooth muscle: 4.2 nTPM (vital, limit 1); esophagus: 3.6 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182185,RAD51B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.3750% (minimum 75%, Missing); lymph node: 64.9254% (minimum 70%, Missing); parathyroid gland: 64.9254% (minimum 70%, Missing); salivary gland: 40.6542% (minimum 70%, Missing); smooth muscle: 67.4419% (minimum 75%, Missing); spinal cord: 71.9008% (minimum 75%, Missing); thymus: 60.0000% (minimum 65%, Missing)",-0.05,-0.293458,-0.20625,0,7,partial,7.3,12.7,5.8,"salivary gland: 12.7 nTPM (protected, limit 3); bone marrow: 7.3 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 3); parathyroid gland: 4.7 nTPM (protected, limit 3); smooth muscle: 4.2 nTPM (vital, limit 1); esophagus: 3.6 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182185,RAD51B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.3750% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.9254% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 64.9254% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 40.6542% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 67.4419% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.9008% (minimum 75%, Baseline (adaptation disabled)); thymus: 60.0000% (minimum 65%, Baseline (adaptation disabled))",-0.05,-0.293458,-0.20625,0,7,partial,7.3,12.7,5.8,"salivary gland: 12.7 nTPM (protected, limit 3); bone marrow: 7.3 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 3); parathyroid gland: 4.7 nTPM (protected, limit 3); smooth muscle: 4.2 nTPM (vital, limit 1); esophagus: 3.6 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182185,RAD51B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 77.7778% (minimum 99%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); salivary gland: 87.5000% (minimum 97%, Missing); skin: 93.3333% (minimum 95%, Missing)",-0.0166667,-0.095,-0.323333,0,80,unavailable,0.7,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182223,ZAR1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 66.6667% (minimum 75%, Missing)",0.283333,0.175,-0.0833333,0,80,unavailable,0.7,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182223,ZAR1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 66.6667% (minimum 75%, Missing)",0.283333,0.175,-0.0833333,0,80,unavailable,0.7,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182223,ZAR1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 66.6667% (minimum 75%, Missing)",0.283333,0.175,-0.0833333,0,80,unavailable,0.7,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182223,ZAR1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.283333,0.175,-0.0833333,0,80,unavailable,0.7,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182223,ZAR1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.7447% (minimum 98%, Approved); amygdala: 92.7835% (minimum 99%, Missing); basal ganglia: 86.5385% (minimum 99%, Missing); cerebellum: 87.3786% (minimum 99%, Missing); cerebral cortex: 78.9474% (minimum 99%, Missing); choroid plexus: 98.9011% (minimum 99%, Missing); hippocampal formation: 91.8367% (minimum 99%, Missing); hypothalamus: 73.1707% (minimum 99%, Missing); kidney: 93.7500% (minimum 98%, Approved); lymph node: 93.7500% (minimum 97%, Missing); midbrain: 96.7742% (minimum 99%, Missing); pituitary gland: 75.6303% (minimum 99%, Missing); retina: 25.4958% (minimum 99%, Missing); salivary gland: 91.8367% (minimum 95%, Approved); spinal cord: 97.8261% (minimum 99%, Missing); spleen: 90.0000% (minimum 95%, Missing); thymus: 90.9091% (minimum 95%, Missing); thyroid gland: 86.5385% (minimum 95%, Missing)",-0.0846154,-0.0325,-0.735042,0,3,partial,26.3,0.8,1.4,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182256,GABRG3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 73.1707% (minimum 75%, Missing); retina: 25.4958% (minimum 75%, Missing)",0.215385,0.2375,-0.495042,0,3,partial,26.3,0.8,1.4,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182256,GABRG3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 73.1707% (minimum 75%, Missing); retina: 25.4958% (minimum 75%, Missing)",0.215385,0.2375,-0.495042,0,3,partial,26.3,0.8,1.4,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182256,GABRG3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 73.1707% (minimum 75%, Missing); retina: 25.4958% (minimum 75%, Missing)",0.215385,0.2375,-0.495042,0,3,partial,26.3,0.8,1.4,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182256,GABRG3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 73.1707% (minimum 75%, Baseline (adaptation disabled)); retina: 25.4958% (minimum 75%, Baseline (adaptation disabled))",0.215385,0.218367,-0.495042,0,3,partial,26.3,0.8,1.4,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182256,GABRG3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 93.3333% (minimum 99%, Missing); retina: 87.5000% (minimum 99%, Missing); skeletal muscle: 93.3333% (minimum 99%, Missing); skin: 22.5806% (minimum 95%, Missing)",-0.724194,0.03,-0.115,0,2,partial,0.2,0,4.8,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182261,NLRP10,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skin: 22.5806% (minimum 65%, Missing)",-0.424194,0.3,0.125,0,2,partial,0.2,0,4.8,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182261,NLRP10,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skin: 22.5806% (minimum 65%, Missing)",-0.424194,0.3,0.125,0,2,partial,0.2,0,4.8,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182261,NLRP10,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skin: 22.5806% (minimum 65%, Missing)",-0.424194,0.3,0.125,0,2,partial,0.2,0,4.8,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182261,NLRP10,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skin: 22.5806% (minimum 65%, Baseline (adaptation disabled))",-0.424194,0.3,0.125,0,2,partial,0.2,0,4.8,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182261,NLRP10,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 92.4623% (minimum 95%, Enhanced)",0.05,0.03,-0.0253769,0,1,partial,1.5,0.9,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182264,IZUMO1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.244595,0,1,partial,1.5,0.9,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182264,IZUMO1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.244595,0,1,partial,1.5,0.9,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182264,IZUMO1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.244595,0,1,partial,1.5,0.9,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182264,IZUMO1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333957,0.253368,0.174623,0,1,partial,1.5,0.9,0.3,"pancreas: 1.5 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182264,IZUMO1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.7654% (minimum 99%, Missing); pituitary gland: 97.1660% (minimum 99%, Missing); retina: 97.1660% (minimum 99%, Missing)",0.05,0.03,-0.0183401,0,2,partial,1.1,0.2,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182308,DCAF4L1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22166,0,2,partial,1.1,0.2,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182308,DCAF4L1,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22166,0,2,partial,1.1,0.2,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182308,DCAF4L1,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22166,0,2,partial,1.1,0.2,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182308,DCAF4L1,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.32561,0.291736,0.206175,0,2,partial,1.1,0.2,0.6,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182308,DCAF4L1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 88.8889% (minimum 99%, Missing); duodenum: 88.8889% (minimum 99%, Missing); thymus: 88.8889% (minimum 95%, Missing)",-0.0611111,0.03,-0.101111,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182315,MBD3L3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.238889,0.3,0.138889,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182315,MBD3L3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.238889,0.3,0.138889,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182315,MBD3L3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.238889,0.3,0.138889,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182315,MBD3L3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.238889,0.3,0.138889,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182315,MBD3L3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9048% (minimum 95%, Missing); adrenal gland: 81.2500% (minimum 99%, Missing); amygdala: 56.5217% (minimum 99%, Missing); basal ganglia: 22.4138% (minimum 99%, Missing); bone marrow: 39.3939% (minimum 99%, Missing); cerebellum: 43.3333% (minimum 99%, Missing); cerebral cortex: 43.3333% (minimum 99%, Missing); choroid plexus: 81.2500% (minimum 99%, Missing); colon: 72.2222% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); esophagus: 52.0000% (minimum 97%, Missing); heart muscle: 76.4706% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 54.1667% (minimum 99%, Missing); kidney: 61.9048% (minimum 99%, Missing); liver: 59.0909% (minimum 99%, Missing); lung: 65.0000% (minimum 99%, Missing); lymph node: 76.4706% (minimum 97%, Missing); midbrain: 52.0000% (minimum 99%, Missing); pancreas: 68.4211% (minimum 99%, Missing); parathyroid gland: 86.6667% (minimum 97%, Missing); pituitary gland: 59.0909% (minimum 99%, Missing); rectum: 81.2500% (minimum 97%, Missing); retina: 2.2337% (minimum 99%, Missing); salivary gland: 68.4211% (minimum 97%, Missing); skeletal muscle: 44.8276% (minimum 99%, Missing); skin: 38.2353% (minimum 95%, Missing); small intestine: 72.2222% (minimum 99%, Missing); smooth muscle: 81.2500% (minimum 99%, Missing); spinal cord: 68.4211% (minimum 99%, Missing); spleen: 68.4211% (minimum 95%, Missing); stomach: 72.2222% (minimum 97%, Missing); thymus: 81.2500% (minimum 95%, Missing); thyroid gland: 52.0000% (minimum 95%, Missing); tongue: 86.6667% (minimum 97%, Missing); urinary bladder: 68.4211% (minimum 97%, Missing)",-0.567647,-0.45,-0.967663,0,80,unavailable,56.9,1.2,2.1,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182324,KCNJ14,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9048% (minimum 65%, Missing); amygdala: 56.5217% (minimum 75%, Missing); basal ganglia: 22.4138% (minimum 75%, Missing); bone marrow: 39.3939% (minimum 75%, Missing); cerebellum: 43.3333% (minimum 75%, Missing); cerebral cortex: 43.3333% (minimum 75%, Missing); esophagus: 52.0000% (minimum 70%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 59.0909% (minimum 75%, Missing); lung: 65.0000% (minimum 75%, Missing); midbrain: 52.0000% (minimum 75%, Missing); pancreas: 68.4211% (minimum 75%, Missing); pituitary gland: 59.0909% (minimum 75%, Missing); retina: 2.2337% (minimum 75%, Missing); salivary gland: 68.4211% (minimum 70%, Missing); skeletal muscle: 44.8276% (minimum 75%, Missing); skin: 38.2353% (minimum 65%, Missing); small intestine: 72.2222% (minimum 75%, Missing); spinal cord: 68.4211% (minimum 75%, Missing); thyroid gland: 52.0000% (minimum 65%, Missing); urinary bladder: 68.4211% (minimum 70%, Missing)",-0.267647,-0.18,-0.727663,0,80,unavailable,56.9,1.2,2.1,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182324,KCNJ14,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9048% (minimum 65%, Missing); amygdala: 56.5217% (minimum 75%, Missing); basal ganglia: 22.4138% (minimum 75%, Missing); bone marrow: 39.3939% (minimum 75%, Missing); cerebellum: 43.3333% (minimum 75%, Missing); cerebral cortex: 43.3333% (minimum 75%, Missing); esophagus: 52.0000% (minimum 70%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 59.0909% (minimum 75%, Missing); lung: 65.0000% (minimum 75%, Missing); midbrain: 52.0000% (minimum 75%, Missing); pancreas: 68.4211% (minimum 75%, Missing); pituitary gland: 59.0909% (minimum 75%, Missing); retina: 2.2337% (minimum 75%, Missing); salivary gland: 68.4211% (minimum 70%, Missing); skeletal muscle: 44.8276% (minimum 75%, Missing); skin: 38.2353% (minimum 65%, Missing); small intestine: 72.2222% (minimum 75%, Missing); spinal cord: 68.4211% (minimum 75%, Missing); thyroid gland: 52.0000% (minimum 65%, Missing); urinary bladder: 68.4211% (minimum 70%, Missing)",-0.267647,-0.18,-0.727663,0,80,unavailable,56.9,1.2,2.1,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182324,KCNJ14,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9048% (minimum 65%, Missing); amygdala: 56.5217% (minimum 75%, Missing); basal ganglia: 22.4138% (minimum 75%, Missing); bone marrow: 39.3939% (minimum 75%, Missing); cerebellum: 43.3333% (minimum 75%, Missing); cerebral cortex: 43.3333% (minimum 75%, Missing); esophagus: 52.0000% (minimum 70%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 59.0909% (minimum 75%, Missing); lung: 65.0000% (minimum 75%, Missing); midbrain: 52.0000% (minimum 75%, Missing); pancreas: 68.4211% (minimum 75%, Missing); pituitary gland: 59.0909% (minimum 75%, Missing); retina: 2.2337% (minimum 75%, Missing); salivary gland: 68.4211% (minimum 70%, Missing); skeletal muscle: 44.8276% (minimum 75%, Missing); skin: 38.2353% (minimum 65%, Missing); small intestine: 72.2222% (minimum 75%, Missing); spinal cord: 68.4211% (minimum 75%, Missing); thyroid gland: 52.0000% (minimum 65%, Missing); urinary bladder: 68.4211% (minimum 70%, Missing)",-0.267647,-0.18,-0.727663,0,80,unavailable,56.9,1.2,2.1,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182324,KCNJ14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9048% (minimum 65%, Baseline (adaptation disabled)); amygdala: 56.5217% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 22.4138% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 39.3939% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.3333% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 43.3333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.0000% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 54.1667% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.9048% (minimum 75%, Baseline (adaptation disabled)); liver: 59.0909% (minimum 75%, Baseline (adaptation disabled)); lung: 65.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 52.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.4211% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 59.0909% (minimum 75%, Baseline (adaptation disabled)); retina: 2.2337% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.4211% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 44.8276% (minimum 75%, Baseline (adaptation disabled)); skin: 38.2353% (minimum 65%, Baseline (adaptation disabled)); small intestine: 72.2222% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.4211% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 52.0000% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 68.4211% (minimum 70%, Baseline (adaptation disabled))",-0.267647,-0.18,-0.727663,0,80,unavailable,56.9,1.2,2.1,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182324,KCNJ14,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.0000% (minimum 95%, Missing); adrenal gland: 68.0000% (minimum 99%, Missing); amygdala: 68.0000% (minimum 99%, Missing); basal ganglia: 62.9630% (minimum 99%, Missing); bone marrow: 38.6364% (minimum 99%, Missing); cerebellum: 60.7143% (minimum 99%, Missing); cerebral cortex: 45.9459% (minimum 99%, Missing); choroid plexus: 68.0000% (minimum 99%, Missing); colon: 65.3846% (minimum 97%, Missing); duodenum: 60.7143% (minimum 99%, Missing); esophagus: 70.8333% (minimum 97%, Missing); heart muscle: 54.8387% (minimum 99%, Missing); hippocampal formation: 65.3846% (minimum 99%, Missing); hypothalamus: 60.7143% (minimum 99%, Missing); kidney: 62.9630% (minimum 99%, Missing); liver: 56.6667% (minimum 99%, Missing); lung: 70.8333% (minimum 99%, Missing); lymph node: 45.9459% (minimum 97%, Missing); midbrain: 62.9630% (minimum 99%, Missing); pancreas: 65.3846% (minimum 99%, Missing); parathyroid gland: 53.1250% (minimum 97%, Missing); pituitary gland: 73.9130% (minimum 99%, Missing); rectum: 60.7143% (minimum 97%, Missing); retina: 42.5000% (minimum 99%, Missing); salivary gland: 70.8333% (minimum 97%, Missing); skeletal muscle: 25.0000% (minimum 99%, Missing); skin: 53.1250% (minimum 95%, Missing); small intestine: 60.7143% (minimum 99%, Missing); smooth muscle: 73.9130% (minimum 99%, Missing); spinal cord: 62.9630% (minimum 99%, Missing); spleen: 54.8387% (minimum 95%, Missing); stomach: 54.8387% (minimum 97%, Missing); thymus: 56.6667% (minimum 95%, Missing); thyroid gland: 62.9630% (minimum 95%, Missing); tongue: 58.6207% (minimum 97%, Missing); urinary bladder: 77.2727% (minimum 97%, Missing)",-0.41875,-0.510541,-0.74,0,80,unavailable,5.1,2,1.5,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182405,PGBD4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.0000% (minimum 75%, Missing); amygdala: 68.0000% (minimum 75%, Missing); basal ganglia: 62.9630% (minimum 75%, Missing); bone marrow: 38.6364% (minimum 75%, Missing); cerebellum: 60.7143% (minimum 75%, Missing); cerebral cortex: 45.9459% (minimum 75%, Missing); choroid plexus: 68.0000% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); duodenum: 60.7143% (minimum 75%, Missing); heart muscle: 54.8387% (minimum 75%, Missing); hippocampal formation: 65.3846% (minimum 75%, Missing); hypothalamus: 60.7143% (minimum 75%, Missing); kidney: 62.9630% (minimum 75%, Missing); liver: 56.6667% (minimum 75%, Missing); lung: 70.8333% (minimum 75%, Missing); lymph node: 45.9459% (minimum 70%, Missing); midbrain: 62.9630% (minimum 75%, Missing); pancreas: 65.3846% (minimum 75%, Missing); parathyroid gland: 53.1250% (minimum 70%, Missing); pituitary gland: 73.9130% (minimum 75%, Missing); rectum: 60.7143% (minimum 70%, Missing); retina: 42.5000% (minimum 75%, Missing); skeletal muscle: 25.0000% (minimum 75%, Missing); skin: 53.1250% (minimum 65%, Missing); small intestine: 60.7143% (minimum 75%, Missing); smooth muscle: 73.9130% (minimum 75%, Missing); spinal cord: 62.9630% (minimum 75%, Missing); spleen: 54.8387% (minimum 65%, Missing); stomach: 54.8387% (minimum 70%, Missing); thymus: 56.6667% (minimum 65%, Missing); thyroid gland: 62.9630% (minimum 65%, Missing); tongue: 58.6207% (minimum 70%, Missing)",-0.11875,-0.240541,-0.5,0,80,unavailable,5.1,2,1.5,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182405,PGBD4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.0000% (minimum 75%, Missing); amygdala: 68.0000% (minimum 75%, Missing); basal ganglia: 62.9630% (minimum 75%, Missing); bone marrow: 38.6364% (minimum 75%, Missing); cerebellum: 60.7143% (minimum 75%, Missing); cerebral cortex: 45.9459% (minimum 75%, Missing); choroid plexus: 68.0000% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); duodenum: 60.7143% (minimum 75%, Missing); heart muscle: 54.8387% (minimum 75%, Missing); hippocampal formation: 65.3846% (minimum 75%, Missing); hypothalamus: 60.7143% (minimum 75%, Missing); kidney: 62.9630% (minimum 75%, Missing); liver: 56.6667% (minimum 75%, Missing); lung: 70.8333% (minimum 75%, Missing); lymph node: 45.9459% (minimum 70%, Missing); midbrain: 62.9630% (minimum 75%, Missing); pancreas: 65.3846% (minimum 75%, Missing); parathyroid gland: 53.1250% (minimum 70%, Missing); pituitary gland: 73.9130% (minimum 75%, Missing); rectum: 60.7143% (minimum 70%, Missing); retina: 42.5000% (minimum 75%, Missing); skeletal muscle: 25.0000% (minimum 75%, Missing); skin: 53.1250% (minimum 65%, Missing); small intestine: 60.7143% (minimum 75%, Missing); smooth muscle: 73.9130% (minimum 75%, Missing); spinal cord: 62.9630% (minimum 75%, Missing); spleen: 54.8387% (minimum 65%, Missing); stomach: 54.8387% (minimum 70%, Missing); thymus: 56.6667% (minimum 65%, Missing); thyroid gland: 62.9630% (minimum 65%, Missing); tongue: 58.6207% (minimum 70%, Missing)",-0.11875,-0.240541,-0.5,0,80,unavailable,5.1,2,1.5,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182405,PGBD4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.0000% (minimum 75%, Missing); amygdala: 68.0000% (minimum 75%, Missing); basal ganglia: 62.9630% (minimum 75%, Missing); bone marrow: 38.6364% (minimum 75%, Missing); cerebellum: 60.7143% (minimum 75%, Missing); cerebral cortex: 45.9459% (minimum 75%, Missing); choroid plexus: 68.0000% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); duodenum: 60.7143% (minimum 75%, Missing); heart muscle: 54.8387% (minimum 75%, Missing); hippocampal formation: 65.3846% (minimum 75%, Missing); hypothalamus: 60.7143% (minimum 75%, Missing); kidney: 62.9630% (minimum 75%, Missing); liver: 56.6667% (minimum 75%, Missing); lung: 70.8333% (minimum 75%, Missing); lymph node: 45.9459% (minimum 70%, Missing); midbrain: 62.9630% (minimum 75%, Missing); pancreas: 65.3846% (minimum 75%, Missing); parathyroid gland: 53.1250% (minimum 70%, Missing); pituitary gland: 73.9130% (minimum 75%, Missing); rectum: 60.7143% (minimum 70%, Missing); retina: 42.5000% (minimum 75%, Missing); skeletal muscle: 25.0000% (minimum 75%, Missing); skin: 53.1250% (minimum 65%, Missing); small intestine: 60.7143% (minimum 75%, Missing); smooth muscle: 73.9130% (minimum 75%, Missing); spinal cord: 62.9630% (minimum 75%, Missing); spleen: 54.8387% (minimum 65%, Missing); stomach: 54.8387% (minimum 70%, Missing); thymus: 56.6667% (minimum 65%, Missing); thyroid gland: 62.9630% (minimum 65%, Missing); tongue: 58.6207% (minimum 70%, Missing)",-0.11875,-0.240541,-0.5,0,80,unavailable,5.1,2,1.5,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182405,PGBD4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.9630% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 38.6364% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.7143% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 45.9459% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 65.3846% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.7143% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 54.8387% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.3846% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.7143% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.9630% (minimum 75%, Baseline (adaptation disabled)); liver: 56.6667% (minimum 75%, Baseline (adaptation disabled)); lung: 70.8333% (minimum 75%, Baseline (adaptation disabled)); lymph node: 45.9459% (minimum 70%, Baseline (adaptation disabled)); midbrain: 62.9630% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.3846% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 53.1250% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 73.9130% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.7143% (minimum 70%, Baseline (adaptation disabled)); retina: 42.5000% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 25.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 53.1250% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.7143% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.9130% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.9630% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.8387% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.8387% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.6667% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.9630% (minimum 65%, Baseline (adaptation disabled)); tongue: 58.6207% (minimum 70%, Baseline (adaptation disabled))",-0.11875,-0.240541,-0.5,0,80,unavailable,5.1,2,1.5,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182405,PGBD4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0466777,0.03,0.01,0,2,partial,0,0,0.1,,,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182459,TEX19,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346678,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182459,TEX19,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346678,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182459,TEX19,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346678,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182459,TEX19,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346678,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182459,TEX19,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.9552% (minimum 99%, Missing); amygdala: 91.9457% (minimum 99%, Missing); basal ganglia: 93.0403% (minimum 99%, Missing); bone marrow: 67.4635% (minimum 99%, Missing); cerebellum: 95.1756% (minimum 99%, Missing); cerebral cortex: 88.5017% (minimum 99%, Missing); choroid plexus: 95.4887% (minimum 99%, Missing); colon: 87.2477% (minimum 97%, Missing); duodenum: 88.8889% (minimum 99%, Missing); esophagus: 83.4840% (minimum 97%, Missing); heart muscle: 89.7923% (minimum 99%, Missing); hippocampal formation: 91.0394% (minimum 99%, Missing); hypothalamus: 89.8320% (minimum 99%, Missing); kidney: 92.8278% (minimum 99%, Missing); liver: 90.0709% (minimum 99%, Missing); lung: 92.1542% (minimum 99%, Missing); lymph node: 74.2690% (minimum 97%, Missing); midbrain: 92.5319% (minimum 99%, Missing); pancreas: 95.4439% (minimum 99%, Missing); parathyroid gland: 95.1756% (minimum 97%, Missing); pituitary gland: 93.0403% (minimum 99%, Missing); rectum: 85.4140% (minimum 97%, Missing); retina: 90.4317% (minimum 99%, Missing); salivary gland: 93.1256% (minimum 97%, Missing); skeletal muscle: 93.4253% (minimum 99%, Missing); skin: 90.8359% (minimum 95%, Missing); small intestine: 89.9513% (minimum 99%, Missing); smooth muscle: 85.9197% (minimum 95%, Enhanced); spinal cord: 92.8702% (minimum 99%, Missing); spleen: 88.0416% (minimum 95%, Missing); stomach: 91.6554% (minimum 97%, Missing); thymus: 68.7648% (minimum 95%, Missing); tongue: 92.6585% (minimum 97%, Missing); urinary bladder: 84.5258% (minimum 97%, Missing)",-0.262352,-0.22731,-0.315365,0,11,partial,98,70.4,92.3,"bone marrow: 98 nTPM (vital, limit 1); thymus: 92.3 nTPM (manageable, limit 5); lymph node: 70.4 nTPM (protected, limit 2); esophagus: 40.2 nTPM (protected, limit 2); urinary bladder: 37.2 nTPM (protected, limit 2); rectum: 34.7 nTPM (protected, limit 2); smooth muscle: 33.3 nTPM (vital, limit 6); colon: 29.7 nTPM (protected, limit 2); spleen: 27.6 nTPM (manageable, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); skin: 20.5 nTPM (manageable, limit 5); hippocampal formation: 20 nTPM (vital, limit 1); stomach: 18.5 nTPM (protected, limit 2); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); salivary gland: 15 nTPM (protected, limit 2); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 2); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182481,KPNA2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 67.4635% (minimum 75%, Missing)",0.0376481,0.0426901,-0.0753652,0,11,partial,98,70.4,92.3,"bone marrow: 98 nTPM (vital, limit 1); thymus: 92.3 nTPM (manageable, limit 5); lymph node: 70.4 nTPM (protected, limit 2); esophagus: 40.2 nTPM (protected, limit 2); urinary bladder: 37.2 nTPM (protected, limit 2); rectum: 34.7 nTPM (protected, limit 2); smooth muscle: 33.3 nTPM (vital, limit 6); colon: 29.7 nTPM (protected, limit 2); spleen: 27.6 nTPM (manageable, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); skin: 20.5 nTPM (manageable, limit 5); hippocampal formation: 20 nTPM (vital, limit 1); stomach: 18.5 nTPM (protected, limit 2); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); salivary gland: 15 nTPM (protected, limit 2); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 2); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182481,KPNA2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 67.4635% (minimum 75%, Missing)",0.0376481,0.0426901,-0.0753652,0,11,partial,98,70.4,92.3,"bone marrow: 98 nTPM (vital, limit 1); thymus: 92.3 nTPM (manageable, limit 5); lymph node: 70.4 nTPM (protected, limit 3); esophagus: 40.2 nTPM (protected, limit 3); urinary bladder: 37.2 nTPM (protected, limit 3); rectum: 34.7 nTPM (protected, limit 3); smooth muscle: 33.3 nTPM (vital, limit 6); colon: 29.7 nTPM (protected, limit 3); spleen: 27.6 nTPM (manageable, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); skin: 20.5 nTPM (manageable, limit 5); hippocampal formation: 20 nTPM (vital, limit 1); stomach: 18.5 nTPM (protected, limit 3); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); salivary gland: 15 nTPM (protected, limit 3); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 3); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182481,KPNA2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 67.4635% (minimum 75%, Missing)",0.0376481,0.0426901,-0.0753652,0,11,partial,98,70.4,92.3,"bone marrow: 98 nTPM (vital, limit 1); thymus: 92.3 nTPM (manageable, limit 5); lymph node: 70.4 nTPM (protected, limit 3); esophagus: 40.2 nTPM (protected, limit 3); urinary bladder: 37.2 nTPM (protected, limit 3); rectum: 34.7 nTPM (protected, limit 3); smooth muscle: 33.3 nTPM (vital, limit 6); colon: 29.7 nTPM (protected, limit 3); spleen: 27.6 nTPM (manageable, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); skin: 20.5 nTPM (manageable, limit 5); hippocampal formation: 20 nTPM (vital, limit 1); stomach: 18.5 nTPM (protected, limit 3); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); salivary gland: 15 nTPM (protected, limit 3); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 3); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182481,KPNA2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 67.4635% (minimum 75%, Baseline (adaptation disabled))",0.0376481,0.0426901,-0.0753652,0,11,partial,98,70.4,92.3,"bone marrow: 98 nTPM (vital, limit 1); thymus: 92.3 nTPM (manageable, limit 5); lymph node: 70.4 nTPM (protected, limit 3); esophagus: 40.2 nTPM (protected, limit 3); urinary bladder: 37.2 nTPM (protected, limit 3); rectum: 34.7 nTPM (protected, limit 3); smooth muscle: 33.3 nTPM (vital, limit 1); colon: 29.7 nTPM (protected, limit 3); spleen: 27.6 nTPM (manageable, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); adipose tissue: 25 nTPM (manageable, limit 5); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); skin: 20.5 nTPM (manageable, limit 5); hippocampal formation: 20 nTPM (vital, limit 1); stomach: 18.5 nTPM (protected, limit 3); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); salivary gland: 15 nTPM (protected, limit 3); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 3); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182481,KPNA2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.7842% (minimum 99%, Missing)",0.05,0.03,-0.00215805,0,7,partial,0.4,0.1,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182583,VCX,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.237842,0,7,partial,0.4,0.1,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182583,VCX,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.237842,0,7,partial,0.4,0.1,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182583,VCX,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.237842,0,7,partial,0.4,0.1,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182583,VCX,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346933,0.296933,0.237842,0,7,partial,0.4,0.1,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182583,VCX,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); bone marrow: 33.3333% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); retina: 66.6667% (minimum 99%, Missing); skin: 66.6667% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing)",-0.283333,0.03,-0.656667,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182613,OR2V2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); small intestine: 66.6667% (minimum 75%, Missing)",0.0166667,0.3,-0.416667,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182613,OR2V2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); small intestine: 66.6667% (minimum 75%, Missing)",0.0166667,0.3,-0.416667,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182613,OR2V2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); small intestine: 66.6667% (minimum 75%, Missing)",0.0166667,0.3,-0.416667,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182613,OR2V2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 75%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.0166667,0.3,-0.416667,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182613,OR2V2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.3471% (minimum 99%, Missing); retina: 79.8658% (minimum 99%, Missing)",0.05,0.0216667,-0.191342,0,80,unavailable,3,0.1,0,"retina: 3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182645,CCDC172,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.291667,0.0486577,0,80,unavailable,3,0.1,0,"retina: 3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182645,CCDC172,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.291667,0.0486577,0,80,unavailable,3,0.1,0,"retina: 3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182645,CCDC172,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.291667,0.0486577,0,80,unavailable,3,0.1,0,"retina: 3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182645,CCDC172,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.291667,0.0486577,0,80,unavailable,3,0.1,0,"retina: 3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182645,CCDC172,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182652,OR4Q3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182652,OR4Q3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182652,OR4Q3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182652,OR4Q3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182652,OR4Q3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.5915% (minimum 99%, Missing); kidney: 94.9796% (minimum 95%, Enhanced); retina: 98.5915% (minimum 99%, Missing); smooth muscle: 94.5946% (minimum 95%, Enhanced)",0.0387006,0.0117672,-0.00408451,0,2,partial,4,8.8,3.9,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182752,PAPPA,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.338701,0.281767,0.235915,0,2,partial,4,8.8,3.9,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182752,PAPPA,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.338701,0.281767,0.235915,0,2,partial,4,8.8,3.9,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182752,PAPPA,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.338701,0.281767,0.235915,0,2,partial,4,8.8,3.9,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182752,PAPPA,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297226,0.188325,0.195946,0,2,partial,4,8.8,3.9,"parathyroid gland: 8.8 nTPM (protected, limit 3); urinary bladder: 4.4 nTPM (protected, limit 3); smooth muscle: 4 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182752,PAPPA,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5294% (minimum 99%, Missing); basal ganglia: 98.5294% (minimum 99%, Missing); cerebral cortex: 97.8102% (minimum 99%, Missing); choroid plexus: 98.5294% (minimum 99%, Missing); heart muscle: 98.5294% (minimum 99%, Missing); hippocampal formation: 98.5294% (minimum 99%, Missing); hypothalamus: 98.5294% (minimum 99%, Missing); kidney: 97.8102% (minimum 99%, Missing); liver: 98.5294% (minimum 99%, Missing); parathyroid gland: 92.4138% (minimum 97%, Missing); pituitary gland: 97.1014% (minimum 99%, Missing); retina: 90.5405% (minimum 99%, Missing); smooth muscle: 98.5294% (minimum 99%, Missing); thyroid gland: 94.3662% (minimum 95%, Missing)",-0.00633803,-0.0458621,-0.0845946,0,80,unavailable,1.4,1.1,0.8,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182791,CCDC87,admission_only,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.293662,0.224138,0.155405,0,80,unavailable,1.4,1.1,0.8,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182791,CCDC87,selectivity_revised,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.293662,0.224138,0.155405,0,80,unavailable,1.4,1.1,0.8,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182791,CCDC87,grid_revised,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.293662,0.224138,0.155405,0,80,unavailable,1.4,1.1,0.8,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182791,CCDC87,current_adaptive,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.293662,0.224138,0.155405,0,80,unavailable,1.4,1.1,0.8,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182791,CCDC87,current_fixed,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182793,GSTA5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182793,GSTA5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182793,GSTA5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182793,GSTA5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182793,GSTA5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 94.1176% (minimum 95%, Missing); choroid plexus: 94.1176% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); heart muscle: 94.1176% (minimum 99%, Missing); pancreas: 45.7143% (minimum 99%, Missing); skeletal muscle: 88.8889% (minimum 99%, Missing); smooth muscle: 94.1176% (minimum 99%, Missing); stomach: 80.0000% (minimum 97%, Missing); tongue: 88.8889% (minimum 97%, Missing)",-0.00882353,-0.17,-0.532857,0,80,unavailable,1.9,0.4,0.1,"pancreas: 1.9 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182798,MAGEB17,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pancreas: 45.7143% (minimum 75%, Missing)",0.291176,0.1,-0.292857,0,80,unavailable,1.9,0.4,0.1,"pancreas: 1.9 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182798,MAGEB17,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pancreas: 45.7143% (minimum 75%, Missing)",0.291176,0.1,-0.292857,0,80,unavailable,1.9,0.4,0.1,"pancreas: 1.9 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182798,MAGEB17,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pancreas: 45.7143% (minimum 75%, Missing)",0.291176,0.1,-0.292857,0,80,unavailable,1.9,0.4,0.1,"pancreas: 1.9 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182798,MAGEB17,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pancreas: 45.7143% (minimum 75%, Baseline (adaptation disabled))",0.291176,0.1,-0.292857,0,80,unavailable,1.9,0.4,0.1,"pancreas: 1.9 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182798,MAGEB17,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.3614% (minimum 95%, Missing); adrenal gland: 89.8204% (minimum 99%, Missing); amygdala: 90.3614% (minimum 99%, Missing); basal ganglia: 89.2857% (minimum 99%, Missing); cerebellum: 98.0392% (minimum 99%, Missing); cerebral cortex: 89.8204% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); esophagus: 96.7742% (minimum 97%, Missing); heart muscle: 94.9367% (minimum 99%, Missing); hippocampal formation: 93.1677% (minimum 99%, Missing); hypothalamus: 92.5926% (minimum 99%, Missing); kidney: 90.3614% (minimum 99%, Missing); liver: 79.7872% (minimum 99%, Missing); lung: 96.7742% (minimum 99%, Missing); midbrain: 91.4634% (minimum 99%, Missing); pancreas: 93.7500% (minimum 99%, Missing); parathyroid gland: 96.7742% (minimum 97%, Missing); pituitary gland: 97.4026% (minimum 99%, Missing); salivary gland: 96.1538% (minimum 97%, Missing); skeletal muscle: 96.7742% (minimum 99%, Missing); small intestine: 97.4026% (minimum 99%, Missing); spinal cord: 94.3396% (minimum 99%, Missing); stomach: 96.1538% (minimum 97%, Missing)",-0.0463855,-0.00846154,-0.192128,0,1,partial,3.8,0.6,1.6,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182890,GLUD2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.253614,0.261538,0.0478723,0,1,partial,3.8,0.6,1.6,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182890,GLUD2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.253614,0.261538,0.0478723,0,1,partial,3.8,0.6,1.6,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182890,GLUD2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.253614,0.261538,0.0478723,0,1,partial,3.8,0.6,1.6,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182890,GLUD2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.253614,0.261538,0.0478723,0,1,partial,3.8,0.6,1.6,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182890,GLUD2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182896,TMEM95,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182896,TMEM95,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182896,TMEM95,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182896,TMEM95,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182896,TMEM95,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 12.5000% (minimum 60%, Enhanced)",-0.475,0.03,0.01,0,1,partial,0,0,0.7,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182898,TCHHL1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 12.5000% (minimum 50%, Enhanced)",-0.375,0.3,0.25,0,1,partial,0,0,0.7,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182898,TCHHL1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 12.5000% (minimum 50%, Enhanced)",-0.375,0.3,0.25,0,1,partial,0,0,0.7,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182898,TCHHL1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 12.5000% (minimum 50%, Enhanced)",-0.375,0.3,0.25,0,1,partial,0,0,0.7,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182898,TCHHL1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 12.5000% (minimum 65%, Baseline (adaptation disabled))",-0.525,0.3,0.25,0,1,partial,0,0,0.7,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182898,TCHHL1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 43.3333% (minimum 95%, Enhanced); amygdala: 17.9724% (minimum 99%, Missing); basal ganglia: 9.4891% (minimum 99%, Missing); cerebellum: 8.4416% (minimum 99%, Missing); cerebral cortex: 8.2105% (minimum 99%, Missing); hippocampal formation: 14.7727% (minimum 99%, Missing); hypothalamus: 19.6970% (minimum 99%, Missing); kidney: 81.2500% (minimum 95%, Enhanced); liver: 92.8571% (minimum 95%, Enhanced); midbrain: 29.5455% (minimum 99%, Missing); pancreas: 92.8571% (minimum 95%, Enhanced); pituitary gland: 58.2090% (minimum 99%, Missing); retina: 48.7500% (minimum 99%, Missing); spinal cord: 42.3913% (minimum 99%, Missing)",0.05,0.0125,-0.907895,0,5,partial,43.6,0.9,0.2,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182901,RGS7,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 43.3333% (minimum 60%, Enhanced); amygdala: 17.9724% (minimum 75%, Missing); basal ganglia: 9.4891% (minimum 75%, Missing); cerebellum: 8.4416% (minimum 75%, Missing); cerebral cortex: 8.2105% (minimum 75%, Missing); hippocampal formation: 14.7727% (minimum 75%, Missing); hypothalamus: 19.6970% (minimum 75%, Missing); midbrain: 29.5455% (minimum 75%, Missing); pituitary gland: 58.2090% (minimum 75%, Missing); retina: 48.7500% (minimum 75%, Missing); spinal cord: 42.3913% (minimum 75%, Missing)",0.35,0.2625,-0.667895,0,5,partial,43.6,0.9,0.2,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182901,RGS7,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 43.3333% (minimum 60%, Enhanced); amygdala: 17.9724% (minimum 75%, Missing); basal ganglia: 9.4891% (minimum 75%, Missing); cerebellum: 8.4416% (minimum 75%, Missing); cerebral cortex: 8.2105% (minimum 75%, Missing); hippocampal formation: 14.7727% (minimum 75%, Missing); hypothalamus: 19.6970% (minimum 75%, Missing); midbrain: 29.5455% (minimum 75%, Missing); pituitary gland: 58.2090% (minimum 75%, Missing); retina: 48.7500% (minimum 75%, Missing); spinal cord: 42.3913% (minimum 75%, Missing)",0.35,0.2625,-0.667895,0,5,partial,43.6,0.9,0.2,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182901,RGS7,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 43.3333% (minimum 60%, Enhanced); amygdala: 17.9724% (minimum 75%, Missing); basal ganglia: 9.4891% (minimum 75%, Missing); cerebellum: 8.4416% (minimum 75%, Missing); cerebral cortex: 8.2105% (minimum 75%, Missing); hippocampal formation: 14.7727% (minimum 75%, Missing); hypothalamus: 19.6970% (minimum 75%, Missing); midbrain: 29.5455% (minimum 75%, Missing); pituitary gland: 58.2090% (minimum 75%, Missing); retina: 48.7500% (minimum 75%, Missing); spinal cord: 42.3913% (minimum 75%, Missing)",0.35,0.2625,-0.667895,0,5,partial,43.6,0.9,0.2,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182901,RGS7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 43.3333% (minimum 75%, Baseline (adaptation disabled)); amygdala: 17.9724% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 9.4891% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 8.4416% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 8.2105% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 14.7727% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 19.6970% (minimum 75%, Baseline (adaptation disabled)); midbrain: 29.5455% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 58.2090% (minimum 75%, Baseline (adaptation disabled)); retina: 48.7500% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 42.3913% (minimum 75%, Baseline (adaptation disabled))",0.30122,0.1125,-0.667895,0,5,partial,43.6,0.9,0.2,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182901,RGS7,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.9914% (minimum 95%, Missing); amygdala: 98.6486% (minimum 99%, Missing); basal ganglia: 98.6486% (minimum 99%, Missing); bone marrow: 98.6486% (minimum 99%, Missing); cerebral cortex: 98.6486% (minimum 99%, Missing); choroid plexus: 88.3065% (minimum 99%, Missing); colon: 94.3966% (minimum 97%, Missing); duodenum: 98.2063% (minimum 99%, Missing); esophagus: 95.2174% (minimum 97%, Missing); heart muscle: 95.6332% (minimum 99%, Missing); hypothalamus: 97.7679% (minimum 99%, Missing); liver: 95.2174% (minimum 99%, Missing); lung: 93.1915% (minimum 99%, Missing); pancreas: 98.2063% (minimum 99%, Missing); pituitary gland: 95.6332% (minimum 99%, Missing); skin: 92.7966% (minimum 95%, Missing); small intestine: 96.4758% (minimum 99%, Missing); smooth muscle: 96.4758% (minimum 99%, Missing); stomach: 92.7966% (minimum 97%, Missing); thyroid gland: 93.9914% (minimum 95%, Missing); urinary bladder: 96.0526% (minimum 97%, Missing)",-0.0220339,-0.0420339,-0.106935,0,80,unavailable,2.9,1.7,1.7,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182950,CIMAP1C,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.277966,0.227966,0.133065,0,80,unavailable,2.9,1.7,1.7,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182950,CIMAP1C,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.277966,0.227966,0.133065,0,80,unavailable,2.9,1.7,1.7,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182950,CIMAP1C,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.277966,0.227966,0.133065,0,80,unavailable,2.9,1.7,1.7,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182950,CIMAP1C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.277966,0.227966,0.133065,0,80,unavailable,2.9,1.7,1.7,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182950,CIMAP1C,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.6667% (minimum 99%, Missing); basal ganglia: 17.0213% (minimum 99%, Missing); cerebellum: 30.7692% (minimum 99%, Missing); cerebral cortex: 19.0476% (minimum 99%, Missing); choroid plexus: 80.0000% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); hippocampal formation: 25.0000% (minimum 99%, Missing); hypothalamus: 12.9032% (minimum 99%, Missing); midbrain: 28.5714% (minimum 99%, Missing); pituitary gland: 88.8889% (minimum 99%, Missing); skin: 88.8889% (minimum 95%, Missing); spinal cord: 57.1429% (minimum 99%, Missing)",-0.0611111,-0.0811111,-0.860968,0,80,unavailable,5.4,0.1,0.1,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182968,SOX1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.6667% (minimum 75%, Missing); basal ganglia: 17.0213% (minimum 75%, Missing); cerebellum: 30.7692% (minimum 75%, Missing); cerebral cortex: 19.0476% (minimum 75%, Missing); hippocampal formation: 25.0000% (minimum 75%, Missing); hypothalamus: 12.9032% (minimum 75%, Missing); midbrain: 28.5714% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing)",0.238889,0.188889,-0.620968,0,80,unavailable,5.4,0.1,0.1,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182968,SOX1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.6667% (minimum 75%, Missing); basal ganglia: 17.0213% (minimum 75%, Missing); cerebellum: 30.7692% (minimum 75%, Missing); cerebral cortex: 19.0476% (minimum 75%, Missing); hippocampal formation: 25.0000% (minimum 75%, Missing); hypothalamus: 12.9032% (minimum 75%, Missing); midbrain: 28.5714% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing)",0.238889,0.188889,-0.620968,0,80,unavailable,5.4,0.1,0.1,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182968,SOX1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.6667% (minimum 75%, Missing); basal ganglia: 17.0213% (minimum 75%, Missing); cerebellum: 30.7692% (minimum 75%, Missing); cerebral cortex: 19.0476% (minimum 75%, Missing); hippocampal formation: 25.0000% (minimum 75%, Missing); hypothalamus: 12.9032% (minimum 75%, Missing); midbrain: 28.5714% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing)",0.238889,0.188889,-0.620968,0,80,unavailable,5.4,0.1,0.1,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182968,SOX1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.6667% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 17.0213% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 30.7692% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 19.0476% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 25.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 12.9032% (minimum 75%, Baseline (adaptation disabled)); midbrain: 28.5714% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.1429% (minimum 75%, Baseline (adaptation disabled))",0.238889,0.188889,-0.620968,0,80,unavailable,5.4,0.1,0.1,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182968,SOX1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182974,OR4M2B,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182974,OR4M2B,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182974,OR4M2B,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182974,OR4M2B,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000182974,OR4M2B,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7020% (minimum 95%, Missing); adrenal gland: 75.6614% (minimum 99%, Missing); amygdala: 95.3333% (minimum 99%, Missing); basal ganglia: 94.7020% (minimum 99%, Missing); bone marrow: 94.7020% (minimum 99%, Missing); cerebellum: 96.6216% (minimum 99%, Missing); cerebral cortex: 95.9732% (minimum 99%, Missing); choroid plexus: 88.8199% (minimum 99%, Missing); colon: 96.6216% (minimum 97%, Missing); heart muscle: 81.7143% (minimum 99%, Missing); hippocampal formation: 94.7020% (minimum 99%, Missing); hypothalamus: 94.0789% (minimum 99%, Missing); kidney: 85.1190% (minimum 99%, Missing); liver: 71.1443% (minimum 99%, Missing); lung: 94.0789% (minimum 99%, Missing); lymph node: 88.8199% (minimum 97%, Missing); midbrain: 93.4641% (minimum 99%, Missing); pancreas: 94.0789% (minimum 99%, Missing); parathyroid gland: 92.8571% (minimum 97%, Missing); pituitary gland: 95.9732% (minimum 99%, Missing); retina: 69.7561% (minimum 99%, Missing); salivary gland: 94.7020% (minimum 97%, Missing); skeletal muscle: 91.6667% (minimum 99%, Missing); small intestine: 96.6216% (minimum 99%, Missing); smooth muscle: 98.6207% (minimum 99%, Missing); spinal cord: 91.6667% (minimum 99%, Missing); spleen: 81.7143% (minimum 95%, Missing); stomach: 94.7020% (minimum 97%, Missing); thyroid gland: 91.6667% (minimum 95%, Missing); tongue: 94.7020% (minimum 97%, Missing)",-0.132857,-0.0818012,-0.292439,0,80,unavailable,6.2,1.8,3.2,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182993,C12orf60,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 71.1443% (minimum 75%, Missing); retina: 69.7561% (minimum 75%, Missing)",0.167143,0.188199,-0.052439,0,80,unavailable,6.2,1.8,3.2,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182993,C12orf60,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 71.1443% (minimum 75%, Missing); retina: 69.7561% (minimum 75%, Missing)",0.167143,0.188199,-0.052439,0,80,unavailable,6.2,1.8,3.2,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182993,C12orf60,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 71.1443% (minimum 75%, Missing); retina: 69.7561% (minimum 75%, Missing)",0.167143,0.188199,-0.052439,0,80,unavailable,6.2,1.8,3.2,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182993,C12orf60,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 71.1443% (minimum 75%, Baseline (adaptation disabled)); retina: 69.7561% (minimum 75%, Baseline (adaptation disabled))",0.167143,0.188199,-0.052439,0,80,unavailable,6.2,1.8,3.2,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000182993,C12orf60,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183024,OR1G1,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183024,OR1G1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183024,OR1G1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183024,OR1G1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183024,OR1G1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 17.4468% (minimum 97%, Missing); duodenum: 93.1818% (minimum 99%, Missing); esophagus: 82.0000% (minimum 97%, Missing); rectum: 28.4722% (minimum 97%, Missing); small intestine: 75.9259% (minimum 99%, Missing); smooth muscle: 93.1818% (minimum 99%, Missing)",0.00348837,-0.795532,-0.230741,0,80,unavailable,1.3,19.4,0.2,"colon: 19.4 nTPM (protected, limit 2); rectum: 10.3 nTPM (protected, limit 2); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183034,OTOP2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 17.4468% (minimum 70%, Missing); rectum: 28.4722% (minimum 70%, Missing)",0.303488,-0.525532,0.00925926,0,80,unavailable,1.3,19.4,0.2,"colon: 19.4 nTPM (protected, limit 2); rectum: 10.3 nTPM (protected, limit 2); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183034,OTOP2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 17.4468% (minimum 70%, Missing); rectum: 28.4722% (minimum 70%, Missing)",0.303488,-0.525532,0.00925926,0,80,unavailable,1.3,19.4,0.2,"colon: 19.4 nTPM (protected, limit 3); rectum: 10.3 nTPM (protected, limit 3); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183034,OTOP2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 17.4468% (minimum 70%, Missing); rectum: 28.4722% (minimum 70%, Missing)",0.303488,-0.525532,0.00925926,0,80,unavailable,1.3,19.4,0.2,"colon: 19.4 nTPM (protected, limit 3); rectum: 10.3 nTPM (protected, limit 3); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183034,OTOP2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 17.4468% (minimum 70%, Baseline (adaptation disabled)); rectum: 28.4722% (minimum 70%, Baseline (adaptation disabled))",0.303488,-0.525532,0.00925926,0,80,unavailable,1.3,19.4,0.2,"colon: 19.4 nTPM (protected, limit 3); rectum: 10.3 nTPM (protected, limit 3); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183034,OTOP2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183035,CYLC1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183035,CYLC1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183035,CYLC1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183035,CYLC1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183035,CYLC1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 96.6480% (minimum 99%, Missing); basal ganglia: 96.1111% (minimum 99%, Missing); choroid plexus: 98.8571% (minimum 99%, Missing); hippocampal formation: 97.7401% (minimum 99%, Missing); hypothalamus: 98.2955% (minimum 99%, Missing); midbrain: 97.7401% (minimum 99%, Missing); pituitary gland: 98.2955% (minimum 99%, Missing); retina: 96.6480% (minimum 99%, Missing); spinal cord: 96.1111% (minimum 99%, Missing)",0.0442529,0.0242529,-0.0288889,0,3,partial,0.7,0.5,0.6,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183066,WBP2NL,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.344253,0.294253,0.211111,0,3,partial,0.7,0.5,0.6,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183066,WBP2NL,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.344253,0.294253,0.211111,0,3,partial,0.7,0.5,0.6,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183066,WBP2NL,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.344253,0.294253,0.211111,0,3,partial,0.7,0.5,0.6,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183066,WBP2NL,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.31648,0.27191,0.211111,0,3,partial,0.7,0.5,0.6,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183066,WBP2NL,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.2676% (minimum 95%, Missing); adrenal gland: 77.6074% (minimum 99%, Missing); amygdala: 82.6797% (minimum 99%, Missing); basal ganglia: 84.6154% (minimum 99%, Missing); bone marrow: 71.6714% (minimum 99%, Missing); cerebellum: 86.6438% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 99%, Missing); choroid plexus: 69.3151% (minimum 99%, Missing); colon: 75.5224% (minimum 97%, Missing); duodenum: 75.0742% (minimum 99%, Missing); esophagus: 80.8307% (minimum 97%, Missing); heart muscle: 77.3700% (minimum 99%, Missing); hippocampal formation: 82.6797% (minimum 99%, Missing); hypothalamus: 84.0532% (minimum 99%, Missing); kidney: 76.6667% (minimum 99%, Missing); liver: 72.2857% (minimum 99%, Missing); lung: 79.8107% (minimum 99%, Missing); lymph node: 74.6313% (minimum 97%, Missing); midbrain: 81.0897% (minimum 99%, Missing); pancreas: 78.0864% (minimum 99%, Missing); parathyroid gland: 60.8173% (minimum 97%, Missing); pituitary gland: 82.4104% (minimum 99%, Missing); rectum: 70.6704% (minimum 97%, Missing); retina: 70.0831% (minimum 99%, Missing); salivary gland: 83.2237% (minimum 97%, Missing); skeletal muscle: 81.3505% (minimum 99%, Missing); skin: 79.5597% (minimum 95%, Missing); small intestine: 76.8997% (minimum 99%, Missing); smooth muscle: 70.8683% (minimum 99%, Missing); spinal cord: 75.0742% (minimum 99%, Missing); spleen: 77.1341% (minimum 95%, Missing); stomach: 78.0864% (minimum 97%, Missing); thymus: 64.3766% (minimum 95%, Missing); thyroid gland: 75.0742% (minimum 95%, Missing); tongue: 80.0633% (minimum 97%, Missing); urinary bladder: 80.3175% (minimum 97%, Missing)",-0.306234,-0.361827,-0.296849,0,3,partial,11.2,16.3,14,"parathyroid gland: 16.3 nTPM (protected, limit 2); thymus: 14 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 2); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); lymph node: 8.6 nTPM (protected, limit 2); thyroid gland: 8.4 nTPM (manageable, limit 5); duodenum: 8.4 nTPM (vital, limit 1); spinal cord: 8.4 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 2); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); cerebral cortex: 6.9 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); esophagus: 6 nTPM (protected, limit 2); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183137,CEP57L1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 71.6714% (minimum 75%, Missing); choroid plexus: 69.3151% (minimum 75%, Missing); liver: 72.2857% (minimum 75%, Missing); parathyroid gland: 60.8173% (minimum 70%, Missing); retina: 70.0831% (minimum 75%, Missing); smooth muscle: 70.8683% (minimum 75%, Missing); thymus: 64.3766% (minimum 65%, Missing)",-0.0062341,-0.0918269,-0.0568493,0,3,partial,11.2,16.3,14,"parathyroid gland: 16.3 nTPM (protected, limit 2); thymus: 14 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 2); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); lymph node: 8.6 nTPM (protected, limit 2); thyroid gland: 8.4 nTPM (manageable, limit 5); duodenum: 8.4 nTPM (vital, limit 1); spinal cord: 8.4 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 2); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); cerebral cortex: 6.9 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); esophagus: 6 nTPM (protected, limit 2); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183137,CEP57L1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 71.6714% (minimum 75%, Missing); choroid plexus: 69.3151% (minimum 75%, Missing); liver: 72.2857% (minimum 75%, Missing); parathyroid gland: 60.8173% (minimum 70%, Missing); retina: 70.0831% (minimum 75%, Missing); smooth muscle: 70.8683% (minimum 75%, Missing); thymus: 64.3766% (minimum 65%, Missing)",-0.0062341,-0.0918269,-0.0568493,0,3,partial,11.2,16.3,14,"parathyroid gland: 16.3 nTPM (protected, limit 3); thymus: 14 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 3); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); lymph node: 8.6 nTPM (protected, limit 3); thyroid gland: 8.4 nTPM (manageable, limit 5); duodenum: 8.4 nTPM (vital, limit 1); spinal cord: 8.4 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 3); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); cerebral cortex: 6.9 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); esophagus: 6 nTPM (protected, limit 3); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 3); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183137,CEP57L1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 71.6714% (minimum 75%, Missing); choroid plexus: 69.3151% (minimum 75%, Missing); liver: 72.2857% (minimum 75%, Missing); parathyroid gland: 60.8173% (minimum 70%, Missing); retina: 70.0831% (minimum 75%, Missing); smooth muscle: 70.8683% (minimum 75%, Missing); thymus: 64.3766% (minimum 65%, Missing)",-0.0062341,-0.0918269,-0.0568493,0,3,partial,11.2,16.3,14,"parathyroid gland: 16.3 nTPM (protected, limit 3); thymus: 14 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 3); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); lymph node: 8.6 nTPM (protected, limit 3); thyroid gland: 8.4 nTPM (manageable, limit 5); duodenum: 8.4 nTPM (vital, limit 1); spinal cord: 8.4 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 3); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); cerebral cortex: 6.9 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); esophagus: 6 nTPM (protected, limit 3); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 3); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183137,CEP57L1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 71.6714% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.3151% (minimum 75%, Baseline (adaptation disabled)); liver: 72.2857% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.8173% (minimum 70%, Baseline (adaptation disabled)); retina: 70.0831% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.8683% (minimum 75%, Baseline (adaptation disabled)); thymus: 64.3766% (minimum 65%, Baseline (adaptation disabled))",-0.0062341,-0.0918269,-0.0568493,0,3,partial,11.2,16.3,14,"parathyroid gland: 16.3 nTPM (protected, limit 3); thymus: 14 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 3); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); lymph node: 8.6 nTPM (protected, limit 3); thyroid gland: 8.4 nTPM (manageable, limit 5); duodenum: 8.4 nTPM (vital, limit 1); spinal cord: 8.4 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 3); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); cerebral cortex: 6.9 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); esophagus: 6 nTPM (protected, limit 3); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 3); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183137,CEP57L1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 22.1429% (minimum 99%, Missing); amygdala: 26.9565% (minimum 99%, Missing); basal ganglia: 14.7619% (minimum 99%, Missing); bone marrow: 83.7838% (minimum 99%, Missing); cerebellum: 5.1926% (minimum 99%, Missing); cerebral cortex: 10.5085% (minimum 99%, Missing); choroid plexus: 79.4872% (minimum 99%, Missing); hippocampal formation: 20.9459% (minimum 99%, Missing); hypothalamus: 28.4404% (minimum 99%, Missing); liver: 93.9394% (minimum 98%, Approved); midbrain: 21.6783% (minimum 99%, Missing); pancreas: 77.5000% (minimum 99%, Missing); pituitary gland: 86.1111% (minimum 99%, Missing); rectum: 96.8750% (minimum 97%, Missing); retina: 63.2653% (minimum 99%, Missing); skin: 48.4375% (minimum 95%, Missing); spinal cord: 15.1961% (minimum 99%, Missing); thymus: 11.3971% (minimum 95%, Missing)",-0.836029,-0.00125,-0.938074,0,3,partial,56.6,0.1,24.1,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183166,CALN1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 22.1429% (minimum 75%, Missing); amygdala: 26.9565% (minimum 75%, Missing); basal ganglia: 14.7619% (minimum 75%, Missing); cerebellum: 5.1926% (minimum 75%, Missing); cerebral cortex: 10.5085% (minimum 75%, Missing); hippocampal formation: 20.9459% (minimum 75%, Missing); hypothalamus: 28.4404% (minimum 75%, Missing); midbrain: 21.6783% (minimum 75%, Missing); retina: 63.2653% (minimum 75%, Missing); skin: 48.4375% (minimum 65%, Missing); spinal cord: 15.1961% (minimum 75%, Missing); thymus: 11.3971% (minimum 65%, Missing)",-0.536029,0.26875,-0.698074,0,3,partial,56.6,0.1,24.1,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183166,CALN1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 22.1429% (minimum 75%, Missing); amygdala: 26.9565% (minimum 75%, Missing); basal ganglia: 14.7619% (minimum 75%, Missing); cerebellum: 5.1926% (minimum 75%, Missing); cerebral cortex: 10.5085% (minimum 75%, Missing); hippocampal formation: 20.9459% (minimum 75%, Missing); hypothalamus: 28.4404% (minimum 75%, Missing); midbrain: 21.6783% (minimum 75%, Missing); retina: 63.2653% (minimum 75%, Missing); skin: 48.4375% (minimum 65%, Missing); spinal cord: 15.1961% (minimum 75%, Missing); thymus: 11.3971% (minimum 65%, Missing)",-0.536029,0.26875,-0.698074,0,3,partial,56.6,0.1,24.1,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183166,CALN1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 22.1429% (minimum 75%, Missing); amygdala: 26.9565% (minimum 75%, Missing); basal ganglia: 14.7619% (minimum 75%, Missing); cerebellum: 5.1926% (minimum 75%, Missing); cerebral cortex: 10.5085% (minimum 75%, Missing); hippocampal formation: 20.9459% (minimum 75%, Missing); hypothalamus: 28.4404% (minimum 75%, Missing); midbrain: 21.6783% (minimum 75%, Missing); retina: 63.2653% (minimum 75%, Missing); skin: 48.4375% (minimum 65%, Missing); spinal cord: 15.1961% (minimum 75%, Missing); thymus: 11.3971% (minimum 65%, Missing)",-0.536029,0.26875,-0.698074,0,3,partial,56.6,0.1,24.1,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183166,CALN1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 22.1429% (minimum 75%, Baseline (adaptation disabled)); amygdala: 26.9565% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 14.7619% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 5.1926% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 10.5085% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 20.9459% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 28.4404% (minimum 75%, Baseline (adaptation disabled)); midbrain: 21.6783% (minimum 75%, Baseline (adaptation disabled)); retina: 63.2653% (minimum 75%, Baseline (adaptation disabled)); skin: 48.4375% (minimum 65%, Baseline (adaptation disabled)); spinal cord: 15.1961% (minimum 75%, Baseline (adaptation disabled)); thymus: 11.3971% (minimum 65%, Baseline (adaptation disabled))",-0.536029,0.26875,-0.698074,0,3,partial,56.6,0.1,24.1,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183166,CALN1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 1.1628% (minimum 99%, Missing)",0.05,0.03,-0.978372,0,80,unavailable,8.5,0,0,"retina: 8.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183185,GABRR3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 1.1628% (minimum 75%, Missing)",0.35,0.3,-0.738372,0,80,unavailable,8.5,0,0,"retina: 8.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183185,GABRR3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 1.1628% (minimum 75%, Missing)",0.35,0.3,-0.738372,0,80,unavailable,8.5,0,0,"retina: 8.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183185,GABRR3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 1.1628% (minimum 75%, Missing)",0.35,0.3,-0.738372,0,80,unavailable,8.5,0,0,"retina: 8.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183185,GABRR3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 1.1628% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.738372,0,80,unavailable,8.5,0,0,"retina: 8.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183185,GABRR3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183206,POTEC,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183206,POTEC,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183206,POTEC,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183206,POTEC,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183206,POTEC,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0115385,0.03,0.01,0,7,partial,0,0,0.2,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183246,RIMBP3C,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.311538,0.3,0.25,0,7,partial,0,0,0.2,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183246,RIMBP3C,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.311538,0.3,0.25,0,7,partial,0,0,0.2,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183246,RIMBP3C,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.311538,0.3,0.25,0,7,partial,0,0,0.2,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183246,RIMBP3C,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.311538,0.3,0.25,0,7,partial,0,0,0.2,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183246,RIMBP3C,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183269,OR52E8,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183269,OR52E8,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183269,OR52E8,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183269,OR52E8,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183269,OR52E8,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.6744% (minimum 99%, Missing); cerebral cortex: 97.6744% (minimum 99%, Missing); heart muscle: 95.4545% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); midbrain: 97.6744% (minimum 99%, Missing); pancreas: 97.6744% (minimum 99%, Missing); retina: 84.0000% (minimum 99%, Missing); skeletal muscle: 97.6744% (minimum 99%, Missing); small intestine: 97.6744% (minimum 99%, Missing); spinal cord: 97.6744% (minimum 99%, Missing)",0.0267442,0.00674419,-0.15,0,80,unavailable,0.8,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183304,FAM9A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.326744,0.276744,0.09,0,80,unavailable,0.8,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183304,FAM9A,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.326744,0.276744,0.09,0,80,unavailable,0.8,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183304,FAM9A,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.326744,0.276744,0.09,0,80,unavailable,0.8,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183304,FAM9A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.326744,0.276744,0.09,0,80,unavailable,0.8,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183304,FAM9A,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183305,MAGEA2B,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183305,MAGEA2B,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183305,MAGEA2B,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183305,MAGEA2B,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183305,MAGEA2B,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183313,OR52L1,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183313,OR52L1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183313,OR52L1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183313,OR52L1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183313,OR52L1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 90.4762% (minimum 95%, Enhanced); retina: 98.7013% (minimum 99%, Missing)",0.05,0.03,-0.0452381,0,3,partial,0.8,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183318,SPDYE4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.237013,0,3,partial,0.8,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183318,SPDYE4,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.237013,0,3,partial,0.8,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183318,SPDYE4,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.237013,0,3,partial,0.8,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183318,SPDYE4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.324359,0.274359,0.154762,0,3,partial,0.8,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183318,SPDYE4,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 89.4366% (minimum 99%, Missing)",0.05,0.03,-0.0956338,0,80,unavailable,4.5,0,0,"heart muscle: 4.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183324,REC114,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.144366,0,80,unavailable,4.5,0,0,"heart muscle: 4.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183324,REC114,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.144366,0,80,unavailable,4.5,0,0,"heart muscle: 4.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183324,REC114,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.144366,0,80,unavailable,4.5,0,0,"heart muscle: 4.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183324,REC114,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.144366,0,80,unavailable,4.5,0,0,"heart muscle: 4.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183324,REC114,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.4109% (minimum 99%, Missing); small intestine: 97.5709% (minimum 99%, Missing)",0.0377049,0.0057085,-0.0558915,0,80,unavailable,1.7,0.6,0.3,"bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183396,TMEM89,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.337705,0.275709,0.184109,0,80,unavailable,1.7,0.6,0.3,"bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183396,TMEM89,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.337705,0.275709,0.184109,0,80,unavailable,1.7,0.6,0.3,"bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183396,TMEM89,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.337705,0.275709,0.184109,0,80,unavailable,1.7,0.6,0.3,"bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183396,TMEM89,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.337705,0.275709,0.184109,0,80,unavailable,1.7,0.6,0.3,"bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183396,TMEM89,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183434,TFDP3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183434,TFDP3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183434,TFDP3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183434,TFDP3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183434,TFDP3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.7500% (minimum 99%, Missing); basal ganglia: 96.7742% (minimum 99%, Missing); cerebral cortex: 93.7500% (minimum 95%, Enhanced); colon: 63.8298% (minimum 97%, Missing); duodenum: 56.6038% (minimum 99%, Missing); hippocampal formation: 96.7742% (minimum 99%, Missing); hypothalamus: 96.7742% (minimum 99%, Missing); midbrain: 96.7742% (minimum 99%, Missing); rectum: 93.7500% (minimum 97%, Missing); retina: 90.9091% (minimum 99%, Missing); small intestine: 62.5000% (minimum 99%, Missing); spinal cord: 96.7742% (minimum 99%, Missing); stomach: 93.7500% (minimum 97%, Missing)",0.05,-0.331702,-0.423962,0,9,partial,2.3,1.7,0.1,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183476,SH2D7,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 63.8298% (minimum 70%, Missing); duodenum: 56.6038% (minimum 75%, Missing); small intestine: 62.5000% (minimum 75%, Missing)",0.35,-0.0617021,-0.183962,0,9,partial,2.3,1.7,0.1,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183476,SH2D7,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 63.8298% (minimum 70%, Missing); duodenum: 56.6038% (minimum 75%, Missing); small intestine: 62.5000% (minimum 75%, Missing)",0.35,-0.0617021,-0.183962,0,9,partial,2.3,1.7,0.1,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183476,SH2D7,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 63.8298% (minimum 70%, Missing); duodenum: 56.6038% (minimum 75%, Missing); small intestine: 62.5000% (minimum 75%, Missing)",0.35,-0.0617021,-0.183962,0,9,partial,2.3,1.7,0.1,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183476,SH2D7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 63.8298% (minimum 70%, Baseline (adaptation disabled)); duodenum: 56.6038% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.5000% (minimum 75%, Baseline (adaptation disabled))",0.317742,-0.0617021,-0.183962,0,9,partial,2.3,1.7,0.1,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183476,SH2D7,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.8085% (minimum 99%, Missing); basal ganglia: 97.6395% (minimum 99%, Missing); cerebellum: 91.9192% (minimum 95%, Enhanced); cerebral cortex: 93.2377% (minimum 95%, Enhanced); heart muscle: 94.5946% (minimum 95%, Enhanced); hippocampal formation: 96.1945% (minimum 99%, Missing); hypothalamus: 97.2222% (minimum 99%, Missing); midbrain: 98.2721% (minimum 99%, Missing); pituitary gland: 98.2721% (minimum 99%, Missing); retina: 98.4848% (minimum 99%, Missing); spinal cord: 98.0603% (minimum 99%, Missing); thymus: 87.8378% (minimum 95%, Missing); tongue: 95.7895% (minimum 97%, Missing)",-0.0716216,-0.0121053,-0.0308081,0,3,partial,4,3.3,6.3,"thymus: 6.3 nTPM (manageable, limit 5); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183496,MEX3B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.228378,0.257895,0.211945,0,3,partial,4,3.3,6.3,"thymus: 6.3 nTPM (manageable, limit 5); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183496,MEX3B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.228378,0.257895,0.211945,0,3,partial,4,3.3,6.3,"thymus: 6.3 nTPM (manageable, limit 5); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183496,MEX3B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.228378,0.257895,0.211945,0,3,partial,4,3.3,6.3,"thymus: 6.3 nTPM (manageable, limit 5); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183496,MEX3B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.228378,0.232377,0.169192,0,3,partial,4,3.3,6.3,"thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); heart muscle: 2.6 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183496,MEX3B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.00668874,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183559,C10orf120,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246689,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183559,C10orf120,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246689,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183559,C10orf120,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246689,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183559,C10orf120,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246689,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183559,C10orf120,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183629,GOLGA8G,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183629,GOLGA8G,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183629,GOLGA8G,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183629,GOLGA8G,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183629,GOLGA8G,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 95.7143% (minimum 99%, Missing); cerebellum: 97.1014% (minimum 99%, Missing); cerebral cortex: 98.5294% (minimum 99%, Missing); hypothalamus: 98.5294% (minimum 99%, Missing); spinal cord: 97.1014% (minimum 99%, Missing)",0.0352941,0.0152941,-0.0328571,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183632,TP53TG3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.335294,0.285294,0.207143,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183632,TP53TG3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.335294,0.285294,0.207143,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183632,TP53TG3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.335294,0.285294,0.207143,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183632,TP53TG3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.335294,0.285294,0.207143,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183632,TP53TG3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 25.0000% (minimum 95%, Missing); skin: 0.3356% (minimum 95%, Missing)",-0.946644,0.03,0.01,0,80,unavailable,0,0,59.4,"skin: 59.4 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183640,KRTAP8-1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 25.0000% (minimum 65%, Missing); skin: 0.3356% (minimum 65%, Missing)",-0.646644,0.3,0.25,0,80,unavailable,0,0,59.4,"skin: 59.4 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183640,KRTAP8-1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 25.0000% (minimum 65%, Missing); skin: 0.3356% (minimum 65%, Missing)",-0.646644,0.3,0.25,0,80,unavailable,0,0,59.4,"skin: 59.4 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183640,KRTAP8-1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 25.0000% (minimum 65%, Missing); skin: 0.3356% (minimum 65%, Missing)",-0.646644,0.3,0.25,0,80,unavailable,0,0,59.4,"skin: 59.4 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183640,KRTAP8-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 25.0000% (minimum 65%, Baseline (adaptation disabled)); skin: 0.3356% (minimum 65%, Baseline (adaptation disabled))",-0.646644,0.3,0.25,0,80,unavailable,0,0,59.4,"skin: 59.4 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183640,KRTAP8-1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.0432% (minimum 99%, Missing); basal ganglia: 94.9052% (minimum 99%, Missing); cerebellum: 93.1395% (minimum 99%, Missing); cerebral cortex: 93.0314% (minimum 99%, Missing); heart muscle: 94.3463% (minimum 99%, Missing); hippocampal formation: 96.8561% (minimum 99%, Missing); hypothalamus: 93.1395% (minimum 99%, Missing); midbrain: 96.8561% (minimum 99%, Missing); pancreas: 98.5240% (minimum 99%, Missing); pituitary gland: 89.1982% (minimum 99%, Missing); retina: 95.8134% (minimum 99%, Missing); spinal cord: 98.7670% (minimum 99%, Missing)",0.0487531,0.0176695,-0.0980178,0,80,unavailable,9.7,1,0.1,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183654,MARCHF11,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348753,0.28767,0.141982,0,80,unavailable,9.7,1,0.1,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183654,MARCHF11,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348753,0.28767,0.141982,0,80,unavailable,9.7,1,0.1,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183654,MARCHF11,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348753,0.28767,0.141982,0,80,unavailable,9.7,1,0.1,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183654,MARCHF11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348753,0.28767,0.141982,0,80,unavailable,9.7,1,0.1,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183654,MARCHF11,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0.7,0.3,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183668,PSG9,admission_only,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.7,0.3,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183668,PSG9,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.7,0.3,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183668,PSG9,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.7,0.3,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183668,PSG9,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.347107,0.297107,0.243276,0,1,partial,0.7,0.3,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183668,PSG9,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183706,OR4N4,admission_only,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183706,OR4N4,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183706,OR4N4,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183706,OR4N4,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183706,OR4N4,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 84.6154% (minimum 99%, Missing)",0.05,0.03,-0.143846,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183753,BPY2,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183753,BPY2,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183753,BPY2,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183753,BPY2,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183753,BPY2,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 84.6154% (minimum 99%, Missing)",0.05,0.03,-0.143846,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183795,BPY2B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183795,BPY2B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183795,BPY2B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183795,BPY2B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000183795,BPY2B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.6415% (minimum 95%, Uncertain); adrenal gland: 68.1416% (minimum 99%, Missing); amygdala: 79.3814% (minimum 99%, Missing); basal ganglia: 77.7778% (minimum 99%, Missing); bone marrow: 70.6422% (minimum 99%, Missing); cerebellum: 65.8120% (minimum 99%, Missing); cerebral cortex: 66.3793% (minimum 99%, Missing); choroid plexus: 83.6957% (minimum 99%, Missing); colon: 68.1416% (minimum 97%, Missing); duodenum: 64.1667% (minimum 99%, Missing); esophagus: 70.6422% (minimum 97%, Missing); heart muscle: 64.7059% (minimum 99%, Uncertain); hippocampal formation: 78.5714% (minimum 99%, Missing); hypothalamus: 81.0526% (minimum 99%, Missing); kidney: 65.8120% (minimum 99%, Missing); liver: 73.3333% (minimum 99%, Missing); lung: 68.1416% (minimum 99%, Uncertain); lymph node: 49.3590% (minimum 97%, Uncertain); midbrain: 81.0526% (minimum 99%, Missing); pancreas: 69.3694% (minimum 99%, Missing); parathyroid gland: 63.1148% (minimum 97%, Missing); pituitary gland: 68.1416% (minimum 99%, Missing); rectum: 65.8120% (minimum 97%, Missing); retina: 43.0168% (minimum 99%, Missing); salivary gland: 63.1148% (minimum 97%, Missing); skeletal muscle: 66.9565% (minimum 99%, Uncertain); skin: 65.2542% (minimum 95%, Missing); small intestine: 64.7059% (minimum 99%, Missing); smooth muscle: 68.7500% (minimum 99%, Uncertain); spinal cord: 76.2376% (minimum 99%, Missing); spleen: 54.2254% (minimum 95%, Uncertain); stomach: 62.0968% (minimum 97%, Missing); thymus: 52.0270% (minimum 95%, Missing); thyroid gland: 54.2254% (minimum 95%, Missing); tongue: 74.0385% (minimum 97%, Missing); urinary bladder: 66.9565% (minimum 97%, Missing)",-0.42973,-0.47641,-0.559832,0,1,partial,10.2,7.9,7.1,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); thymus: 7.1 nTPM (manageable, limit 5); thyroid gland: 6.5 nTPM (manageable, limit 5); spleen: 6.5 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); cerebellum: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183808,RBM12B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.1416% (minimum 75%, Missing); bone marrow: 70.6422% (minimum 75%, Missing); cerebellum: 65.8120% (minimum 75%, Missing); cerebral cortex: 66.3793% (minimum 75%, Missing); colon: 68.1416% (minimum 70%, Missing); duodenum: 64.1667% (minimum 75%, Missing); heart muscle: 64.7059% (minimum 75%, Uncertain); kidney: 65.8120% (minimum 75%, Missing); liver: 73.3333% (minimum 75%, Missing); lung: 68.1416% (minimum 75%, Uncertain); lymph node: 49.3590% (minimum 70%, Uncertain); pancreas: 69.3694% (minimum 75%, Missing); parathyroid gland: 63.1148% (minimum 70%, Missing); pituitary gland: 68.1416% (minimum 75%, Missing); rectum: 65.8120% (minimum 70%, Missing); retina: 43.0168% (minimum 75%, Missing); salivary gland: 63.1148% (minimum 70%, Missing); skeletal muscle: 66.9565% (minimum 75%, Uncertain); small intestine: 64.7059% (minimum 75%, Missing); smooth muscle: 68.7500% (minimum 75%, Uncertain); spleen: 54.2254% (minimum 65%, Uncertain); stomach: 62.0968% (minimum 70%, Missing); thymus: 52.0270% (minimum 65%, Missing); thyroid gland: 54.2254% (minimum 65%, Missing); urinary bladder: 66.9565% (minimum 70%, Missing)",-0.12973,-0.20641,-0.319832,0,1,partial,10.2,7.9,7.1,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); thymus: 7.1 nTPM (manageable, limit 5); thyroid gland: 6.5 nTPM (manageable, limit 5); spleen: 6.5 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); cerebellum: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183808,RBM12B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.1416% (minimum 75%, Missing); bone marrow: 70.6422% (minimum 75%, Missing); cerebellum: 65.8120% (minimum 75%, Missing); cerebral cortex: 66.3793% (minimum 75%, Missing); colon: 68.1416% (minimum 70%, Missing); duodenum: 64.1667% (minimum 75%, Missing); heart muscle: 64.7059% (minimum 75%, Uncertain); kidney: 65.8120% (minimum 75%, Missing); liver: 73.3333% (minimum 75%, Missing); lung: 68.1416% (minimum 75%, Uncertain); lymph node: 49.3590% (minimum 70%, Uncertain); pancreas: 69.3694% (minimum 75%, Missing); parathyroid gland: 63.1148% (minimum 70%, Missing); pituitary gland: 68.1416% (minimum 75%, Missing); rectum: 65.8120% (minimum 70%, Missing); retina: 43.0168% (minimum 75%, Missing); salivary gland: 63.1148% (minimum 70%, Missing); skeletal muscle: 66.9565% (minimum 75%, Uncertain); small intestine: 64.7059% (minimum 75%, Missing); smooth muscle: 68.7500% (minimum 75%, Uncertain); spleen: 54.2254% (minimum 65%, Uncertain); stomach: 62.0968% (minimum 70%, Missing); thymus: 52.0270% (minimum 65%, Missing); thyroid gland: 54.2254% (minimum 65%, Missing); urinary bladder: 66.9565% (minimum 70%, Missing)",-0.12973,-0.20641,-0.319832,0,1,partial,10.2,7.9,7.1,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); thymus: 7.1 nTPM (manageable, limit 5); thyroid gland: 6.5 nTPM (manageable, limit 5); spleen: 6.5 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 3); salivary gland: 4.5 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); cerebral cortex: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183808,RBM12B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.1416% (minimum 75%, Missing); bone marrow: 70.6422% (minimum 75%, Missing); cerebellum: 65.8120% (minimum 75%, Missing); cerebral cortex: 66.3793% (minimum 75%, Missing); colon: 68.1416% (minimum 70%, Missing); duodenum: 64.1667% (minimum 75%, Missing); heart muscle: 64.7059% (minimum 75%, Uncertain); kidney: 65.8120% (minimum 75%, Missing); liver: 73.3333% (minimum 75%, Missing); lung: 68.1416% (minimum 75%, Uncertain); lymph node: 49.3590% (minimum 70%, Uncertain); pancreas: 69.3694% (minimum 75%, Missing); parathyroid gland: 63.1148% (minimum 70%, Missing); pituitary gland: 68.1416% (minimum 75%, Missing); rectum: 65.8120% (minimum 70%, Missing); retina: 43.0168% (minimum 75%, Missing); salivary gland: 63.1148% (minimum 70%, Missing); skeletal muscle: 66.9565% (minimum 75%, Uncertain); small intestine: 64.7059% (minimum 75%, Missing); smooth muscle: 68.7500% (minimum 75%, Uncertain); spleen: 54.2254% (minimum 65%, Uncertain); stomach: 62.0968% (minimum 70%, Missing); thymus: 52.0270% (minimum 65%, Missing); thyroid gland: 54.2254% (minimum 65%, Missing); urinary bladder: 66.9565% (minimum 70%, Missing)",-0.12973,-0.20641,-0.319832,0,1,partial,10.2,7.9,7.1,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); thymus: 7.1 nTPM (manageable, limit 5); thyroid gland: 6.5 nTPM (manageable, limit 5); spleen: 6.5 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 3); salivary gland: 4.5 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); cerebral cortex: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183808,RBM12B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.1416% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 70.6422% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.8120% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.3793% (minimum 75%, Baseline (adaptation disabled)); colon: 68.1416% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.1667% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 64.7059% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.8120% (minimum 75%, Baseline (adaptation disabled)); liver: 73.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 68.1416% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.3590% (minimum 70%, Baseline (adaptation disabled)); pancreas: 69.3694% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.1148% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 68.1416% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.8120% (minimum 70%, Baseline (adaptation disabled)); retina: 43.0168% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.1148% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 66.9565% (minimum 75%, Baseline (adaptation disabled)); small intestine: 64.7059% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.7500% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.2254% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.0968% (minimum 70%, Baseline (adaptation disabled)); thymus: 52.0270% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.2254% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 66.9565% (minimum 70%, Baseline (adaptation disabled))",-0.12973,-0.20641,-0.319832,0,1,partial,10.2,7.9,7.1,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); thymus: 7.1 nTPM (manageable, limit 5); thyroid gland: 6.5 nTPM (manageable, limit 5); spleen: 6.5 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 3); salivary gland: 4.5 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); cerebral cortex: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183808,RBM12B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 82.5503% (minimum 99%, Missing); basal ganglia: 69.4915% (minimum 99%, Missing); cerebral cortex: 82.0000% (minimum 95%, Enhanced); choroid plexus: 66.4865% (minimum 99%, Missing); hippocampal formation: 81.4570% (minimum 99%, Missing); hypothalamus: 81.4570% (minimum 99%, Missing); kidney: 91.1111% (minimum 95%, Enhanced); lung: 91.7910% (minimum 95%, Enhanced); midbrain: 88.4892% (minimum 99%, Missing); parathyroid gland: 57.7465% (minimum 80%, Enhanced); pituitary gland: 87.2340% (minimum 99%, Missing); retina: 83.1081% (minimum 99%, Missing); smooth muscle: 92.4812% (minimum 95%, Enhanced); spinal cord: 92.4812% (minimum 99%, Missing)",0.034,-0.222535,-0.325135,0,6,partial,6.2,9,0.5,"choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183831,ANKRD45,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 69.4915% (minimum 75%, Missing); choroid plexus: 66.4865% (minimum 75%, Missing)",0.334,0.0274648,-0.0851351,0,6,partial,6.2,9,0.5,"choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183831,ANKRD45,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 69.4915% (minimum 75%, Missing); choroid plexus: 66.4865% (minimum 75%, Missing)",0.334,0.0274648,-0.0851351,0,6,partial,6.2,9,0.5,"choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183831,ANKRD45,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 69.4915% (minimum 75%, Missing); choroid plexus: 66.4865% (minimum 75%, Missing)",0.334,0.0274648,-0.0851351,0,6,partial,6.2,9,0.5,"choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183831,ANKRD45,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 69.4915% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.4865% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.7465% (minimum 70%, Baseline (adaptation disabled))",0.310937,-0.122535,-0.0851351,0,6,partial,6.2,9,0.5,"parathyroid gland: 9 nTPM (protected, limit 3); choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183831,ANKRD45,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.2611% (minimum 97%, Supported); amygdala: 92.5676% (minimum 99%, Missing); basal ganglia: 87.8205% (minimum 99%, Missing); cerebellum: 93.8356% (minimum 97%, Supported); cerebral cortex: 93.8356% (minimum 97%, Supported); choroid plexus: 46.4407% (minimum 99%, Missing); hippocampal formation: 90.7285% (minimum 99%, Missing); hypothalamus: 85.6250% (minimum 99%, Missing); kidney: 85.0932% (minimum 97%, Supported); lung: 87.2611% (minimum 97%, Supported); midbrain: 94.4828% (minimum 99%, Missing); pancreas: 74.4565% (minimum 97%, Supported); parathyroid gland: 77.8409% (minimum 90%, Supported); pituitary gland: 66.1836% (minimum 99%, Missing); retina: 77.4011% (minimum 99%, Missing); small intestine: 95.8042% (minimum 97%, Supported); smooth muscle: 95.1389% (minimum 97%, Supported); spinal cord: 95.1389% (minimum 99%, Missing); stomach: 89.5425% (minimum 90%, Supported); thyroid gland: 75.2747% (minimum 80%, Supported)",-0.0472527,-0.121591,-0.525593,0,4,partial,15.8,3.9,4.5,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 3); retina: 4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183833,CFAP91,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.4407% (minimum 75%, Missing); pituitary gland: 66.1836% (minimum 75%, Missing)",0.202747,0.178409,-0.285593,0,4,partial,15.8,3.9,4.5,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 3); retina: 4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183833,CFAP91,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.4407% (minimum 75%, Missing); pituitary gland: 66.1836% (minimum 75%, Missing)",0.202747,0.178409,-0.285593,0,4,partial,15.8,3.9,4.5,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 3); retina: 4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183833,CFAP91,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.4407% (minimum 75%, Missing); pituitary gland: 66.1836% (minimum 75%, Missing)",0.202747,0.178409,-0.285593,0,4,partial,15.8,3.9,4.5,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 3); retina: 4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183833,CFAP91,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.4407% (minimum 75%, Baseline (adaptation disabled)); pancreas: 74.4565% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 66.1836% (minimum 75%, Baseline (adaptation disabled))",0.102747,0.0784091,-0.285593,0,4,partial,15.8,3.9,4.5,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); kidney: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183833,CFAP91,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.4545% (minimum 99%, Missing); basal ganglia: 91.3043% (minimum 99%, Missing); cerebellum: 97.6744% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 39.2523% (minimum 95%, Approved); duodenum: 48.2759% (minimum 98%, Approved); esophagus: 84.0000% (minimum 97%, Missing); hippocampal formation: 97.6744% (minimum 99%, Missing); hypothalamus: 97.6744% (minimum 99%, Missing); kidney: 61.7647% (minimum 99%, Missing); liver: 56.7568% (minimum 98%, Approved); lung: 52.5000% (minimum 99%, Missing); midbrain: 95.4545% (minimum 99%, Missing); pancreas: 52.5000% (minimum 98%, Approved); parathyroid gland: 46.1538% (minimum 95%, Approved); pituitary gland: 97.6744% (minimum 99%, Missing); rectum: 43.2990% (minimum 95%, Approved); salivary gland: 89.3617% (minimum 95%, Approved); skin: 80.7692% (minimum 95%, Missing); small intestine: 53.8462% (minimum 98%, Approved); smooth muscle: 93.3333% (minimum 98%, Approved); stomach: 41.5842% (minimum 95%, Approved); thyroid gland: 76.3636% (minimum 90%, Approved); urinary bladder: 62.6866% (minimum 95%, Approved)",-0.142308,-0.557477,-0.497241,0,1,partial,4.5,6.5,1.3,"colon: 6.5 nTPM (protected, limit 4); stomach: 5.9 nTPM (protected, limit 4); rectum: 5.5 nTPM (protected, limit 4); parathyroid gland: 4.9 nTPM (protected, limit 4); duodenum: 4.5 nTPM (vital, limit 2); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 2); small intestine: 3.6 nTPM (vital, limit 2); liver: 3.2 nTPM (vital, limit 2); kidney: 2.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183840,GPR39,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 39.2523% (minimum 65%, Approved); duodenum: 48.2759% (minimum 70%, Approved); kidney: 61.7647% (minimum 75%, Missing); liver: 56.7568% (minimum 70%, Approved); lung: 52.5000% (minimum 75%, Missing); pancreas: 52.5000% (minimum 70%, Approved); parathyroid gland: 46.1538% (minimum 65%, Approved); rectum: 43.2990% (minimum 65%, Approved); small intestine: 53.8462% (minimum 70%, Approved); stomach: 41.5842% (minimum 65%, Approved); urinary bladder: 62.6866% (minimum 65%, Approved)",0.157692,-0.257477,-0.225,0,1,partial,4.5,6.5,1.3,"colon: 6.5 nTPM (protected, limit 4); stomach: 5.9 nTPM (protected, limit 4); rectum: 5.5 nTPM (protected, limit 4); parathyroid gland: 4.9 nTPM (protected, limit 4); duodenum: 4.5 nTPM (vital, limit 2); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 2); small intestine: 3.6 nTPM (vital, limit 2); liver: 3.2 nTPM (vital, limit 2); kidney: 2.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183840,GPR39,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 39.2523% (minimum 65%, Approved); duodenum: 48.2759% (minimum 70%, Approved); kidney: 61.7647% (minimum 75%, Missing); liver: 56.7568% (minimum 70%, Approved); lung: 52.5000% (minimum 75%, Missing); pancreas: 52.5000% (minimum 70%, Approved); parathyroid gland: 46.1538% (minimum 65%, Approved); rectum: 43.2990% (minimum 65%, Approved); small intestine: 53.8462% (minimum 70%, Approved); stomach: 41.5842% (minimum 65%, Approved); urinary bladder: 62.6866% (minimum 65%, Approved)",0.157692,-0.257477,-0.225,0,1,partial,4.5,6.5,1.3,"colon: 6.5 nTPM (protected, limit 4); stomach: 5.9 nTPM (protected, limit 4); rectum: 5.5 nTPM (protected, limit 4); parathyroid gland: 4.9 nTPM (protected, limit 4); duodenum: 4.5 nTPM (vital, limit 2); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 2); small intestine: 3.6 nTPM (vital, limit 2); liver: 3.2 nTPM (vital, limit 2); kidney: 2.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183840,GPR39,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 39.2523% (minimum 65%, Approved); duodenum: 48.2759% (minimum 70%, Approved); kidney: 61.7647% (minimum 75%, Missing); liver: 56.7568% (minimum 70%, Approved); lung: 52.5000% (minimum 75%, Missing); pancreas: 52.5000% (minimum 70%, Approved); parathyroid gland: 46.1538% (minimum 65%, Approved); rectum: 43.2990% (minimum 65%, Approved); small intestine: 53.8462% (minimum 70%, Approved); stomach: 41.5842% (minimum 65%, Approved); urinary bladder: 62.6866% (minimum 65%, Approved)",0.157692,-0.257477,-0.225,0,1,partial,4.5,6.5,1.3,"colon: 6.5 nTPM (protected, limit 4); stomach: 5.9 nTPM (protected, limit 4); rectum: 5.5 nTPM (protected, limit 4); parathyroid gland: 4.9 nTPM (protected, limit 4); duodenum: 4.5 nTPM (vital, limit 2); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 2); small intestine: 3.6 nTPM (vital, limit 2); liver: 3.2 nTPM (vital, limit 2); kidney: 2.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183840,GPR39,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 39.2523% (minimum 70%, Baseline (adaptation disabled)); duodenum: 48.2759% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.7647% (minimum 75%, Baseline (adaptation disabled)); liver: 56.7568% (minimum 75%, Baseline (adaptation disabled)); lung: 52.5000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 52.5000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 46.1538% (minimum 70%, Baseline (adaptation disabled)); rectum: 43.2990% (minimum 70%, Baseline (adaptation disabled)); small intestine: 53.8462% (minimum 75%, Baseline (adaptation disabled)); stomach: 41.5842% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.6866% (minimum 70%, Baseline (adaptation disabled))",0.113636,-0.307477,-0.267241,0,1,partial,4.5,6.5,1.3,"colon: 6.5 nTPM (protected, limit 3); stomach: 5.9 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); parathyroid gland: 4.9 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183840,GPR39,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.0784% (minimum 99%, Missing); amygdala: 94.2308% (minimum 99%, Missing); basal ganglia: 96.0784% (minimum 99%, Missing); bone marrow: 75.3846% (minimum 99%, Missing); cerebellum: 96.0784% (minimum 99%, Missing); cerebral cortex: 74.2424% (minimum 99%, Missing); choroid plexus: 94.2308% (minimum 99%, Missing); colon: 92.4528% (minimum 97%, Missing); duodenum: 98.0000% (minimum 99%, Missing); esophagus: 90.7407% (minimum 97%, Missing); heart muscle: 92.4528% (minimum 99%, Missing); hippocampal formation: 96.0784% (minimum 99%, Missing); hypothalamus: 90.7407% (minimum 99%, Missing); kidney: 96.0784% (minimum 99%, Missing); liver: 98.0000% (minimum 99%, Missing); lung: 89.0909% (minimum 99%, Missing); lymph node: 73.1343% (minimum 97%, Missing); midbrain: 94.2308% (minimum 99%, Missing); pancreas: 94.2308% (minimum 99%, Missing); parathyroid gland: 87.5000% (minimum 97%, Missing); pituitary gland: 98.0000% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 84.4828% (minimum 99%, Missing); salivary gland: 96.0784% (minimum 97%, Missing); skeletal muscle: 94.2308% (minimum 99%, Missing); skin: 92.4528% (minimum 95%, Missing); smooth muscle: 83.0508% (minimum 99%, Missing); spinal cord: 94.2308% (minimum 99%, Missing); spleen: 92.4528% (minimum 95%, Missing); stomach: 96.0784% (minimum 97%, Missing); thymus: 66.2162% (minimum 95%, Missing); thyroid gland: 83.0508% (minimum 95%, Missing); tongue: 96.0784% (minimum 97%, Missing); urinary bladder: 92.4528% (minimum 97%, Missing)",-0.287838,-0.238657,-0.247576,0,80,unavailable,1.7,1.8,2.5,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183850,ZNF730,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 74.2424% (minimum 75%, Missing)",0.0121622,0.0313433,-0.00757576,0,80,unavailable,1.7,1.8,2.5,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183850,ZNF730,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 74.2424% (minimum 75%, Missing)",0.0121622,0.0313433,-0.00757576,0,80,unavailable,1.7,1.8,2.5,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183850,ZNF730,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 74.2424% (minimum 75%, Missing)",0.0121622,0.0313433,-0.00757576,0,80,unavailable,1.7,1.8,2.5,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183850,ZNF730,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 74.2424% (minimum 75%, Baseline (adaptation disabled))",0.0121622,0.0313433,-0.00757576,0,80,unavailable,1.7,1.8,2.5,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183850,ZNF730,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183862,CNGA2,admission_only,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183862,CNGA2,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183862,CNGA2,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183862,CNGA2,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183862,CNGA2,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 80.2548% (minimum 99%, Missing); cerebellum: 88.7324% (minimum 95%, Enhanced); cerebral cortex: 91.9708% (minimum 95%, Enhanced); choroid plexus: 81.2903% (minimum 99%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing); hypothalamus: 89.3617% (minimum 99%, Missing); lung: 87.5000% (minimum 95%, Enhanced); midbrain: 98.4375% (minimum 99%, Missing); parathyroid gland: 55.2632% (minimum 80%, Enhanced); pituitary gland: 96.9231% (minimum 99%, Missing); retina: 38.5321% (minimum 99%, Missing); spinal cord: 97.6744% (minimum 99%, Missing)",0.0267442,-0.247368,-0.604679,0,4,partial,20.1,10.2,0.4,"retina: 20.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183914,DNAH2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 38.5321% (minimum 75%, Missing)",0.326744,0.00263158,-0.364679,0,4,partial,20.1,10.2,0.4,"retina: 20.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183914,DNAH2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 38.5321% (minimum 75%, Missing)",0.326744,0.00263158,-0.364679,0,4,partial,20.1,10.2,0.4,"retina: 20.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183914,DNAH2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 38.5321% (minimum 75%, Missing)",0.326744,0.00263158,-0.364679,0,4,partial,20.1,10.2,0.4,"retina: 20.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183914,DNAH2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"parathyroid gland: 55.2632% (minimum 70%, Baseline (adaptation disabled)); retina: 38.5321% (minimum 75%, Baseline (adaptation disabled))",0.319231,-0.147368,-0.364679,0,4,partial,20.1,10.2,0.4,"retina: 20.1 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 3); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183914,DNAH2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 79.1209% (minimum 95%, Enhanced); hypothalamus: 98.6301% (minimum 99%, Missing); retina: 94.7368% (minimum 99%, Missing)",0.05,0.0163014,-0.158791,0,4,partial,1.9,0.1,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183977,PP2D1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.286301,0.191209,0,4,partial,1.9,0.1,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183977,PP2D1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.286301,0.191209,0,4,partial,1.9,0.1,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183977,PP2D1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.286301,0.191209,0,4,partial,1.9,0.1,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183977,PP2D1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.322973,0.286301,0.0412088,0,4,partial,1.9,0.1,0.2,"bone marrow: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000183977,PP2D1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 6.6667% (minimum 95%, Missing)",-0.883333,0.03,0.01,0,80,unavailable,0,0,1.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184032,KRTAP20-2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 6.6667% (minimum 65%, Missing)",-0.583333,0.3,0.25,0,80,unavailable,0,0,1.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184032,KRTAP20-2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 6.6667% (minimum 65%, Missing)",-0.583333,0.3,0.25,0,80,unavailable,0,0,1.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184032,KRTAP20-2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 6.6667% (minimum 65%, Missing)",-0.583333,0.3,0.25,0,80,unavailable,0,0,1.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184032,KRTAP20-2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 6.6667% (minimum 65%, Baseline (adaptation disabled))",-0.583333,0.3,0.25,0,80,unavailable,0,0,1.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184032,KRTAP20-2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0.2,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184033,CTAG1B,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.2,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184033,CTAG1B,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.2,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184033,CTAG1B,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.2,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184033,CTAG1B,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.336667,0.286667,0.223684,0,3,partial,0.2,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184033,CTAG1B,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184108,TRIML1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184108,TRIML1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184108,TRIML1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184108,TRIML1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184108,TRIML1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 86.7470% (minimum 97%, Missing); skin: 4.8616% (minimum 95%, Missing); thymus: 88.8889% (minimum 95%, Missing)",-0.901384,-0.10253,0.01,0,5,partial,0.1,1.1,140.9,"skin: 140.9 nTPM (manageable, limit 5)",esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / cells in granular layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184148,SPRR4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 4.8616% (minimum 65%, Missing)",-0.601384,0.16747,0.25,0,5,partial,0.1,1.1,140.9,"skin: 140.9 nTPM (manageable, limit 5)",esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / cells in granular layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184148,SPRR4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 4.8616% (minimum 65%, Missing)",-0.601384,0.16747,0.25,0,5,partial,0.1,1.1,140.9,"skin: 140.9 nTPM (manageable, limit 5)",esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / cells in granular layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184148,SPRR4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 4.8616% (minimum 65%, Missing)",-0.601384,0.16747,0.25,0,5,partial,0.1,1.1,140.9,"skin: 140.9 nTPM (manageable, limit 5)",esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / cells in granular layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184148,SPRR4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 4.8616% (minimum 65%, Baseline (adaptation disabled))",-0.601384,0.16747,0.236301,0,5,partial,0.1,1.1,140.9,"skin: 140.9 nTPM (manageable, limit 5)",esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / cells in granular layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184148,SPRR4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 76.9231% (minimum 99%, Missing); bone marrow: 40.0000% (minimum 99%, Missing); cerebral cortex: 55.5556% (minimum 99%, Missing); choroid plexus: 50.0000% (minimum 99%, Missing); colon: 83.3333% (minimum 97%, Missing); duodenum: 71.4286% (minimum 99%, Missing); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 76.9231% (minimum 99%, Missing); kidney: 58.8235% (minimum 99%, Missing); liver: 58.8235% (minimum 99%, Missing); lung: 71.4286% (minimum 99%, Missing); lymph node: 55.5556% (minimum 97%, Missing); pancreas: 76.9231% (minimum 99%, Missing); parathyroid gland: 83.3333% (minimum 97%, Missing); rectum: 76.9231% (minimum 97%, Missing); retina: 30.3030% (minimum 99%, Missing); salivary gland: 62.5000% (minimum 97%, Missing); skeletal muscle: 62.5000% (minimum 99%, Missing); skin: 47.6190% (minimum 95%, Missing); small intestine: 71.4286% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spleen: 55.5556% (minimum 95%, Missing); stomach: 71.4286% (minimum 97%, Missing); thymus: 71.4286% (minimum 95%, Missing); thyroid gland: 45.4545% (minimum 95%, Missing); tongue: 76.9231% (minimum 97%, Missing); urinary bladder: 76.9231% (minimum 97%, Missing)",-0.495455,-0.414444,-0.68697,0,80,unavailable,2.3,0.8,1.2,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184166,OR1D2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"bone marrow: 40.0000% (minimum 75%, Missing); cerebral cortex: 55.5556% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); kidney: 58.8235% (minimum 75%, Missing); liver: 58.8235% (minimum 75%, Missing); lung: 71.4286% (minimum 75%, Missing); lymph node: 55.5556% (minimum 70%, Missing); retina: 30.3030% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); skin: 47.6190% (minimum 65%, Missing); small intestine: 71.4286% (minimum 75%, Missing); spleen: 55.5556% (minimum 65%, Missing); thyroid gland: 45.4545% (minimum 65%, Missing)",-0.195455,-0.144444,-0.44697,0,80,unavailable,2.3,0.8,1.2,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184166,OR1D2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"bone marrow: 40.0000% (minimum 75%, Missing); cerebral cortex: 55.5556% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); kidney: 58.8235% (minimum 75%, Missing); liver: 58.8235% (minimum 75%, Missing); lung: 71.4286% (minimum 75%, Missing); lymph node: 55.5556% (minimum 70%, Missing); retina: 30.3030% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); skin: 47.6190% (minimum 65%, Missing); small intestine: 71.4286% (minimum 75%, Missing); spleen: 55.5556% (minimum 65%, Missing); thyroid gland: 45.4545% (minimum 65%, Missing)",-0.195455,-0.144444,-0.44697,0,80,unavailable,2.3,0.8,1.2,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184166,OR1D2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"bone marrow: 40.0000% (minimum 75%, Missing); cerebral cortex: 55.5556% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); kidney: 58.8235% (minimum 75%, Missing); liver: 58.8235% (minimum 75%, Missing); lung: 71.4286% (minimum 75%, Missing); lymph node: 55.5556% (minimum 70%, Missing); retina: 30.3030% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); skin: 47.6190% (minimum 65%, Missing); small intestine: 71.4286% (minimum 75%, Missing); spleen: 55.5556% (minimum 65%, Missing); thyroid gland: 45.4545% (minimum 65%, Missing)",-0.195455,-0.144444,-0.44697,0,80,unavailable,2.3,0.8,1.2,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184166,OR1D2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"bone marrow: 40.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 55.5556% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 50.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 71.4286% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.8235% (minimum 75%, Baseline (adaptation disabled)); liver: 58.8235% (minimum 75%, Baseline (adaptation disabled)); lung: 71.4286% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.5556% (minimum 70%, Baseline (adaptation disabled)); retina: 30.3030% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); skin: 47.6190% (minimum 65%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.5556% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 45.4545% (minimum 65%, Baseline (adaptation disabled))",-0.195455,-0.144444,-0.44697,0,80,unavailable,2.3,0.8,1.2,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184166,OR1D2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 3.1250% (minimum 99%, Missing); pituitary gland: 0.3597% (minimum 99%, Missing); retina: 1.5385% (minimum 99%, Missing); skeletal muscle: 33.3333% (minimum 98%, Approved)",0.05,0.03,-0.986403,0,0,routine_complete,27.7,0,0,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184302,SIX6,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 3.1250% (minimum 75%, Missing); pituitary gland: 0.3597% (minimum 75%, Missing); retina: 1.5385% (minimum 75%, Missing); skeletal muscle: 33.3333% (minimum 70%, Approved)",0.35,0.3,-0.746403,0,0,routine_complete,27.7,0,0,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184302,SIX6,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 3.1250% (minimum 75%, Missing); pituitary gland: 0.3597% (minimum 75%, Missing); retina: 1.5385% (minimum 75%, Missing); skeletal muscle: 33.3333% (minimum 70%, Approved)",0.35,0.3,-0.746403,0,0,routine_complete,27.7,0,0,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184302,SIX6,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 3.1250% (minimum 75%, Missing); pituitary gland: 0.3597% (minimum 75%, Missing); retina: 1.5385% (minimum 75%, Missing); skeletal muscle: 33.3333% (minimum 70%, Approved)",0.35,0.3,-0.746403,0,0,routine_complete,27.7,0,0,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184302,SIX6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 3.1250% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 0.3597% (minimum 75%, Baseline (adaptation disabled)); retina: 1.5385% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 33.3333% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.746403,0,0,routine_complete,27.7,0,0,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184302,SIX6,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.5926% (minimum 95%, Missing); adrenal gland: 69.4444% (minimum 99%, Uncertain); amygdala: 92.5926% (minimum 99%, Missing); basal ganglia: 89.2857% (minimum 99%, Missing); bone marrow: 78.1250% (minimum 99%, Uncertain); cerebellum: 78.1250% (minimum 99%, Uncertain); cerebral cortex: 75.7576% (minimum 99%, Missing); choroid plexus: 92.5926% (minimum 99%, Missing); colon: 92.5926% (minimum 97%, Missing); duodenum: 89.2857% (minimum 99%, Missing); esophagus: 96.1538% (minimum 97%, Uncertain); heart muscle: 73.5294% (minimum 99%, Uncertain); hippocampal formation: 86.2069% (minimum 99%, Missing); hypothalamus: 89.2857% (minimum 99%, Missing); kidney: 73.5294% (minimum 99%, Uncertain); liver: 96.1538% (minimum 99%, Uncertain); lung: 92.5926% (minimum 99%, Missing); lymph node: 86.2069% (minimum 97%, Uncertain); midbrain: 96.1538% (minimum 99%, Missing); pancreas: 83.3333% (minimum 99%, Uncertain); parathyroid gland: 92.5926% (minimum 97%, Uncertain); pituitary gland: 86.2069% (minimum 99%, Missing); rectum: 92.5926% (minimum 97%, Missing); retina: 43.1034% (minimum 99%, Missing); salivary gland: 73.5294% (minimum 97%, Uncertain); skin: 83.3333% (minimum 95%, Missing); small intestine: 89.2857% (minimum 99%, Missing); smooth muscle: 96.1538% (minimum 99%, Missing); spinal cord: 92.5926% (minimum 99%, Missing); spleen: 89.2857% (minimum 95%, Uncertain); stomach: 86.2069% (minimum 97%, Missing); thymus: 92.5926% (minimum 95%, Missing); thyroid gland: 78.1250% (minimum 95%, Missing); tongue: 96.1538% (minimum 97%, Missing); urinary bladder: 83.3333% (minimum 97%, Uncertain)",-0.16875,-0.234706,-0.558966,0,2,partial,3.3,0.9,0.7,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184305,CCSER1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.4444% (minimum 75%, Uncertain); heart muscle: 73.5294% (minimum 75%, Uncertain); kidney: 73.5294% (minimum 75%, Uncertain); retina: 43.1034% (minimum 75%, Missing)",0.13125,0.0352941,-0.318966,0,2,partial,3.3,0.9,0.7,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184305,CCSER1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.4444% (minimum 75%, Uncertain); heart muscle: 73.5294% (minimum 75%, Uncertain); kidney: 73.5294% (minimum 75%, Uncertain); retina: 43.1034% (minimum 75%, Missing)",0.13125,0.0352941,-0.318966,0,2,partial,3.3,0.9,0.7,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184305,CCSER1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.4444% (minimum 75%, Uncertain); heart muscle: 73.5294% (minimum 75%, Uncertain); kidney: 73.5294% (minimum 75%, Uncertain); retina: 43.1034% (minimum 75%, Missing)",0.13125,0.0352941,-0.318966,0,2,partial,3.3,0.9,0.7,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184305,CCSER1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.4444% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 73.5294% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.5294% (minimum 75%, Baseline (adaptation disabled)); retina: 43.1034% (minimum 75%, Baseline (adaptation disabled))",0.13125,0.0352941,-0.318966,0,2,partial,3.3,0.9,0.7,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184305,CCSER1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 32.0988% (minimum 97%, Missing); skin: 61.9048% (minimum 95%, Missing)",-0.330952,-0.649012,0.01,0,2,partial,0,5.5,1.6,"esophagus: 5.5 nTPM (protected, limit 2)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184330,S100A7A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 32.0988% (minimum 70%, Missing); skin: 61.9048% (minimum 65%, Missing)",-0.0309524,-0.379012,0.25,0,2,partial,0,5.5,1.6,"esophagus: 5.5 nTPM (protected, limit 2)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184330,S100A7A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 32.0988% (minimum 70%, Missing); skin: 61.9048% (minimum 65%, Missing)",-0.0309524,-0.379012,0.25,0,2,partial,0,5.5,1.6,"esophagus: 5.5 nTPM (protected, limit 3)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184330,S100A7A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 32.0988% (minimum 70%, Missing); skin: 61.9048% (minimum 65%, Missing)",-0.0309524,-0.379012,0.25,0,2,partial,0,5.5,1.6,"esophagus: 5.5 nTPM (protected, limit 3)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184330,S100A7A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 32.0988% (minimum 70%, Baseline (adaptation disabled)); skin: 61.9048% (minimum 65%, Baseline (adaptation disabled))",-0.0309524,-0.379012,0.25,0,2,partial,0,5.5,1.6,"esophagus: 5.5 nTPM (protected, limit 3)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184330,S100A7A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184345,IQCF2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184345,IQCF2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184345,IQCF2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184345,IQCF2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184345,IQCF2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00834499,0,1,partial,0.5,0.3,0.1,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184361,SPATA32,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.5,0.3,0.1,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184361,SPATA32,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.5,0.3,0.1,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184361,SPATA32,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.5,0.3,0.1,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184361,SPATA32,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347647,0.292974,0.238345,0,1,partial,0.5,0.3,0.1,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184361,SPATA32,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 92.6893% (minimum 95%, Enhanced); amygdala: 72.3014% (minimum 99%, Missing); basal ganglia: 62.7208% (minimum 99%, Missing); cerebellum: 59.9662% (minimum 99%, Missing); cerebral cortex: 53.1437% (minimum 99%, Missing); choroid plexus: 94.9198% (minimum 99%, Missing); hippocampal formation: 71.4286% (minimum 99%, Missing); hypothalamus: 62.9433% (minimum 99%, Missing); kidney: 91.2596% (minimum 99%, Missing); midbrain: 71.5726% (minimum 99%, Missing); pituitary gland: 90.3308% (minimum 99%, Missing); retina: 71.5726% (minimum 99%, Missing); spinal cord: 85.5422% (minimum 99%, Missing); stomach: 80.6818% (minimum 97%, Missing); thymus: 94.1645% (minimum 95%, Missing)",-0.00835544,-0.163182,-0.458563,0,4,partial,31.3,8.5,2.2,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 2); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184368,MAP7D2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.3014% (minimum 75%, Missing); basal ganglia: 62.7208% (minimum 75%, Missing); cerebellum: 59.9662% (minimum 75%, Missing); cerebral cortex: 53.1437% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 62.9433% (minimum 75%, Missing); midbrain: 71.5726% (minimum 75%, Missing); retina: 71.5726% (minimum 75%, Missing)",0.291645,0.106818,-0.218563,0,4,partial,31.3,8.5,2.2,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 2); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184368,MAP7D2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.3014% (minimum 75%, Missing); basal ganglia: 62.7208% (minimum 75%, Missing); cerebellum: 59.9662% (minimum 75%, Missing); cerebral cortex: 53.1437% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 62.9433% (minimum 75%, Missing); midbrain: 71.5726% (minimum 75%, Missing); retina: 71.5726% (minimum 75%, Missing)",0.291645,0.106818,-0.218563,0,4,partial,31.3,8.5,2.2,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 3); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184368,MAP7D2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.3014% (minimum 75%, Missing); basal ganglia: 62.7208% (minimum 75%, Missing); cerebellum: 59.9662% (minimum 75%, Missing); cerebral cortex: 53.1437% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 62.9433% (minimum 75%, Missing); midbrain: 71.5726% (minimum 75%, Missing); retina: 71.5726% (minimum 75%, Missing)",0.291645,0.106818,-0.218563,0,4,partial,31.3,8.5,2.2,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 3); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184368,MAP7D2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.3014% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.7208% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 59.9662% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.1437% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.4286% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.9433% (minimum 75%, Baseline (adaptation disabled)); midbrain: 71.5726% (minimum 75%, Baseline (adaptation disabled)); retina: 71.5726% (minimum 75%, Baseline (adaptation disabled))",0.291645,0.106818,-0.218563,0,4,partial,31.3,8.5,2.2,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 3); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184368,MAP7D2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.4630% (minimum 99%, Missing); basal ganglia: 97.2574% (minimum 99%, Missing); cerebellum: 97.8769% (minimum 98%, Approved); cerebral cortex: 97.4630% (minimum 98%, Approved); choroid plexus: 95.2479% (minimum 99%, Missing); duodenum: 97.6695% (minimum 98%, Approved); heart muscle: 97.4630% (minimum 98%, Approved); hippocampal formation: 98.5043% (minimum 99%, Missing); hypothalamus: 97.4630% (minimum 99%, Missing); kidney: 95.2479% (minimum 98%, Approved); liver: 94.4672% (minimum 98%, Approved); lung: 97.6695% (minimum 98%, Approved); midbrain: 97.6695% (minimum 99%, Missing); pituitary gland: 97.2574% (minimum 99%, Missing); retina: 98.5043% (minimum 99%, Missing); smooth muscle: 96.8487% (minimum 98%, Approved); spinal cord: 98.5043% (minimum 99%, Missing)",0.0329424,0.0150427,-0.0375207,0,1,partial,2.7,1.6,1.5,"liver: 2.7 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184378,ACTRT3,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.332942,0.285043,0.202479,0,1,partial,2.7,1.6,1.5,"liver: 2.7 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184378,ACTRT3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.332942,0.285043,0.202479,0,1,partial,2.7,1.6,1.5,"liver: 2.7 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184378,ACTRT3,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.332942,0.285043,0.202479,0,1,partial,2.7,1.6,1.5,"liver: 2.7 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184378,ACTRT3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.318487,0.266457,0.194672,0,1,partial,2.7,1.6,1.5,"liver: 2.7 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184378,ACTRT3,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 95.6522% (minimum 99%, Missing); esophagus: 95.6522% (minimum 97%, Missing); salivary gland: 95.6522% (minimum 97%, Missing); skeletal muscle: 91.6667% (minimum 99%, Missing); skin: 4.7414% (minimum 95%, Missing); thymus: 91.6667% (minimum 95%, Missing)",-0.902586,-0.0134783,-0.0733333,0,80,unavailable,0.2,0.1,44.2,"skin: 44.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184459,BPIFC,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.7414% (minimum 65%, Missing)",-0.602586,0.256522,0.166667,0,80,unavailable,0.2,0.1,44.2,"skin: 44.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184459,BPIFC,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.7414% (minimum 65%, Missing)",-0.602586,0.256522,0.166667,0,80,unavailable,0.2,0.1,44.2,"skin: 44.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184459,BPIFC,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.7414% (minimum 65%, Missing)",-0.602586,0.256522,0.166667,0,80,unavailable,0.2,0.1,44.2,"skin: 44.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184459,BPIFC,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.7414% (minimum 65%, Baseline (adaptation disabled))",-0.602586,0.256522,0.166667,0,80,unavailable,0.2,0.1,44.2,"skin: 44.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184459,BPIFC,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184478,OR56A3,admission_only,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184478,OR56A3,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184478,OR56A3,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184478,OR56A3,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184478,OR56A3,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2381% (minimum 99%, Missing); basal ganglia: 93.0233% (minimum 99%, Missing); duodenum: 6.7227% (minimum 95%, Enhanced); hippocampal formation: 97.5610% (minimum 99%, Missing); hypothalamus: 88.8889% (minimum 99%, Missing); kidney: 93.0233% (minimum 95%, Enhanced); lung: 53.3333% (minimum 95%, Enhanced); midbrain: 97.5610% (minimum 99%, Missing); pituitary gland: 97.5610% (minimum 99%, Missing); spleen: 30.5344% (minimum 60%, Enhanced); stomach: 0.0430% (minimum 97%, Missing); thymus: 48.7805% (minimum 95%, Missing)",-0.462195,-0.96957,-0.882773,0,8,partial,55.5,9294.1,9.1,"stomach: 9294.1 nTPM (protected, limit 2); duodenum: 55.5 nTPM (vital, limit 6)",stomach 2 / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184502,GAST,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 6.7227% (minimum 60%, Enhanced); lung: 53.3333% (minimum 60%, Enhanced); spleen: 30.5344% (minimum 50%, Enhanced); stomach: 0.0430% (minimum 70%, Missing); thymus: 48.7805% (minimum 65%, Missing)",-0.194656,-0.69957,-0.532773,0,8,partial,55.5,9294.1,9.1,"stomach: 9294.1 nTPM (protected, limit 2); duodenum: 55.5 nTPM (vital, limit 6)",stomach 2 / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184502,GAST,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 6.7227% (minimum 60%, Enhanced); lung: 53.3333% (minimum 60%, Enhanced); spleen: 30.5344% (minimum 50%, Enhanced); stomach: 0.0430% (minimum 70%, Missing); thymus: 48.7805% (minimum 65%, Missing)",-0.194656,-0.69957,-0.532773,0,8,partial,55.5,9294.1,9.1,"stomach: 9294.1 nTPM (protected, limit 3); duodenum: 55.5 nTPM (vital, limit 6)",stomach 2 / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184502,GAST,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 6.7227% (minimum 60%, Enhanced); lung: 53.3333% (minimum 60%, Enhanced); spleen: 30.5344% (minimum 50%, Enhanced); stomach: 0.0430% (minimum 70%, Missing); thymus: 48.7805% (minimum 65%, Missing)",-0.194656,-0.69957,-0.532773,0,8,partial,55.5,9294.1,9.1,"stomach: 9294.1 nTPM (protected, limit 3); duodenum: 55.5 nTPM (vital, limit 6)",stomach 2 / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184502,GAST,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 6.7227% (minimum 75%, Baseline (adaptation disabled)); lung: 53.3333% (minimum 75%, Baseline (adaptation disabled)); spleen: 30.5344% (minimum 65%, Baseline (adaptation disabled)); stomach: 0.0430% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.7805% (minimum 65%, Baseline (adaptation disabled))",-0.344656,-0.69957,-0.682773,0,8,partial,55.5,9294.1,9.1,"stomach: 9294.1 nTPM (protected, limit 3); duodenum: 55.5 nTPM (vital, limit 1); spleen: 9.1 nTPM (manageable, limit 5); lung: 3.5 nTPM (vital, limit 1)",stomach 2 / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184502,GAST,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0.2,0.1,0.2,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184507,NUTM1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0.2,0.1,0.2,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184507,NUTM1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0.2,0.1,0.2,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184507,NUTM1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0.2,0.1,0.2,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184507,NUTM1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.339691,0.294819,0.239691,0,5,partial,0.2,0.1,0.2,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184507,NUTM1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00839615,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184560,SPEM2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248396,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184560,SPEM2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248396,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184560,SPEM2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248396,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184560,SPEM2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248396,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184560,SPEM2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 80.0000% (minimum 97%, Missing)",0.05,-0.17,0.01,0,80,unavailable,0,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184571,PIWIL3,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.1,0.25,0,80,unavailable,0,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184571,PIWIL3,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.1,0.25,0,80,unavailable,0,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184571,PIWIL3,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.1,0.25,0,80,unavailable,0,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184571,PIWIL3,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.1,0.25,0,80,unavailable,0,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184571,PIWIL3,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 37.1429% (minimum 99%, Missing); amygdala: 93.9759% (minimum 99%, Missing); basal ganglia: 98.7342% (minimum 99%, Missing); cerebellum: 67.8261% (minimum 98%, Approved); cerebral cortex: 95.1220% (minimum 98%, Approved); choroid plexus: 97.5000% (minimum 99%, Missing); hippocampal formation: 96.2963% (minimum 99%, Missing); hypothalamus: 93.9759% (minimum 99%, Missing); midbrain: 74.2857% (minimum 99%, Missing); pituitary gland: 96.2963% (minimum 99%, Missing); retina: 14.9140% (minimum 99%, Missing); spinal cord: 87.6404% (minimum 99%, Missing)",0.0373418,0.012963,-0.84086,0,1,partial,44.5,0.3,0.3,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184599,TAFA3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 37.1429% (minimum 75%, Missing); cerebellum: 67.8261% (minimum 70%, Approved); midbrain: 74.2857% (minimum 75%, Missing); retina: 14.9140% (minimum 75%, Missing)",0.337342,0.3,-0.60086,0,1,partial,44.5,0.3,0.3,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184599,TAFA3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 37.1429% (minimum 75%, Missing); cerebellum: 67.8261% (minimum 70%, Approved); midbrain: 74.2857% (minimum 75%, Missing); retina: 14.9140% (minimum 75%, Missing)",0.337342,0.3,-0.60086,0,1,partial,44.5,0.3,0.3,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184599,TAFA3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 37.1429% (minimum 75%, Missing); cerebellum: 67.8261% (minimum 70%, Approved); midbrain: 74.2857% (minimum 75%, Missing); retina: 14.9140% (minimum 75%, Missing)",0.337342,0.3,-0.60086,0,1,partial,44.5,0.3,0.3,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184599,TAFA3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 37.1429% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.8261% (minimum 75%, Baseline (adaptation disabled)); midbrain: 74.2857% (minimum 75%, Baseline (adaptation disabled)); retina: 14.9140% (minimum 75%, Baseline (adaptation disabled))",0.312963,0.262963,-0.60086,0,1,partial,44.5,0.3,0.3,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184599,TAFA3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 29.7845% (minimum 95%, Missing); adrenal gland: 45.1056% (minimum 99%, Missing); amygdala: 17.1533% (minimum 99%, Missing); basal ganglia: 12.2587% (minimum 99%, Missing); bone marrow: 49.2662% (minimum 99%, Missing); cerebellum: 20.5420% (minimum 99%, Missing); cerebral cortex: 14.6875% (minimum 99%, Missing); choroid plexus: 61.6798% (minimum 99%, Missing); colon: 59.0452% (minimum 97%, Missing); duodenum: 72.7554% (minimum 99%, Missing); esophagus: 55.9524% (minimum 97%, Missing); heart muscle: 46.0784% (minimum 99%, Missing); hippocampal formation: 17.4074% (minimum 99%, Missing); hypothalamus: 30.4010% (minimum 99%, Missing); kidney: 62.6667% (minimum 99%, Missing); liver: 72.3077% (minimum 99%, Missing); lung: 52.9279% (minimum 99%, Missing); lymph node: 43.8433% (minimum 97%, Missing); midbrain: 17.7761% (minimum 99%, Missing); pancreas: 73.6677% (minimum 99%, Missing); parathyroid gland: 70.9970% (minimum 97%, Missing); pituitary gland: 61.0390% (minimum 99%, Missing); rectum: 80.7560% (minimum 97%, Missing); retina: 37.4204% (minimum 99%, Missing); salivary gland: 56.9007% (minimum 97%, Missing); skeletal muscle: 17.4981% (minimum 99%, Missing); skin: 62.0053% (minimum 95%, Missing); small intestine: 62.6667% (minimum 99%, Missing); smooth muscle: 69.7329% (minimum 99%, Missing); spinal cord: 31.1258% (minimum 99%, Missing); spleen: 41.0839% (minimum 95%, Missing); stomach: 63.3423% (minimum 97%, Missing); thymus: 45.8090% (minimum 95%, Missing); thyroid gland: 58.4577% (minimum 95%, Missing); tongue: 39.8305% (minimum 97%, Missing); urinary bladder: 56.9007% (minimum 97%, Missing)",-0.652155,-0.571695,-0.867413,0,2,partial,168.2,35.5,55.4,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (manageable, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 2); spleen: 33.7 nTPM (manageable, limit 5); lymph node: 30.1 nTPM (protected, limit 2); adrenal gland: 28.6 nTPM (vital, limit 1); thymus: 27.8 nTPM (manageable, limit 5); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); lung: 20.9 nTPM (vital, limit 1); esophagus: 18.5 nTPM (protected, limit 2); urinary bladder: 17.8 nTPM (protected, limit 2); salivary gland: 17.8 nTPM (protected, limit 2); thyroid gland: 16.7 nTPM (manageable, limit 5); colon: 16.3 nTPM (protected, limit 2); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); skin: 14.4 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 2); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 2); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184602,SNN,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 29.7845% (minimum 65%, Missing); adrenal gland: 45.1056% (minimum 75%, Missing); amygdala: 17.1533% (minimum 75%, Missing); basal ganglia: 12.2587% (minimum 75%, Missing); bone marrow: 49.2662% (minimum 75%, Missing); cerebellum: 20.5420% (minimum 75%, Missing); cerebral cortex: 14.6875% (minimum 75%, Missing); choroid plexus: 61.6798% (minimum 75%, Missing); colon: 59.0452% (minimum 70%, Missing); duodenum: 72.7554% (minimum 75%, Missing); esophagus: 55.9524% (minimum 70%, Missing); heart muscle: 46.0784% (minimum 75%, Missing); hippocampal formation: 17.4074% (minimum 75%, Missing); hypothalamus: 30.4010% (minimum 75%, Missing); kidney: 62.6667% (minimum 75%, Missing); liver: 72.3077% (minimum 75%, Missing); lung: 52.9279% (minimum 75%, Missing); lymph node: 43.8433% (minimum 70%, Missing); midbrain: 17.7761% (minimum 75%, Missing); pancreas: 73.6677% (minimum 75%, Missing); pituitary gland: 61.0390% (minimum 75%, Missing); retina: 37.4204% (minimum 75%, Missing); salivary gland: 56.9007% (minimum 70%, Missing); skeletal muscle: 17.4981% (minimum 75%, Missing); skin: 62.0053% (minimum 65%, Missing); small intestine: 62.6667% (minimum 75%, Missing); smooth muscle: 69.7329% (minimum 75%, Missing); spinal cord: 31.1258% (minimum 75%, Missing); spleen: 41.0839% (minimum 65%, Missing); stomach: 63.3423% (minimum 70%, Missing); thymus: 45.8090% (minimum 65%, Missing); thyroid gland: 58.4577% (minimum 65%, Missing); tongue: 39.8305% (minimum 70%, Missing); urinary bladder: 56.9007% (minimum 70%, Missing)",-0.352155,-0.301695,-0.627413,0,2,partial,168.2,35.5,55.4,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (manageable, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 2); spleen: 33.7 nTPM (manageable, limit 5); lymph node: 30.1 nTPM (protected, limit 2); adrenal gland: 28.6 nTPM (vital, limit 1); thymus: 27.8 nTPM (manageable, limit 5); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); lung: 20.9 nTPM (vital, limit 1); esophagus: 18.5 nTPM (protected, limit 2); urinary bladder: 17.8 nTPM (protected, limit 2); salivary gland: 17.8 nTPM (protected, limit 2); thyroid gland: 16.7 nTPM (manageable, limit 5); colon: 16.3 nTPM (protected, limit 2); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); skin: 14.4 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 2); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 2); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184602,SNN,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 29.7845% (minimum 65%, Missing); adrenal gland: 45.1056% (minimum 75%, Missing); amygdala: 17.1533% (minimum 75%, Missing); basal ganglia: 12.2587% (minimum 75%, Missing); bone marrow: 49.2662% (minimum 75%, Missing); cerebellum: 20.5420% (minimum 75%, Missing); cerebral cortex: 14.6875% (minimum 75%, Missing); choroid plexus: 61.6798% (minimum 75%, Missing); colon: 59.0452% (minimum 70%, Missing); duodenum: 72.7554% (minimum 75%, Missing); esophagus: 55.9524% (minimum 70%, Missing); heart muscle: 46.0784% (minimum 75%, Missing); hippocampal formation: 17.4074% (minimum 75%, Missing); hypothalamus: 30.4010% (minimum 75%, Missing); kidney: 62.6667% (minimum 75%, Missing); liver: 72.3077% (minimum 75%, Missing); lung: 52.9279% (minimum 75%, Missing); lymph node: 43.8433% (minimum 70%, Missing); midbrain: 17.7761% (minimum 75%, Missing); pancreas: 73.6677% (minimum 75%, Missing); pituitary gland: 61.0390% (minimum 75%, Missing); retina: 37.4204% (minimum 75%, Missing); salivary gland: 56.9007% (minimum 70%, Missing); skeletal muscle: 17.4981% (minimum 75%, Missing); skin: 62.0053% (minimum 65%, Missing); small intestine: 62.6667% (minimum 75%, Missing); smooth muscle: 69.7329% (minimum 75%, Missing); spinal cord: 31.1258% (minimum 75%, Missing); spleen: 41.0839% (minimum 65%, Missing); stomach: 63.3423% (minimum 70%, Missing); thymus: 45.8090% (minimum 65%, Missing); thyroid gland: 58.4577% (minimum 65%, Missing); tongue: 39.8305% (minimum 70%, Missing); urinary bladder: 56.9007% (minimum 70%, Missing)",-0.352155,-0.301695,-0.627413,0,2,partial,168.2,35.5,55.4,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (manageable, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 3); spleen: 33.7 nTPM (manageable, limit 5); lymph node: 30.1 nTPM (protected, limit 3); adrenal gland: 28.6 nTPM (vital, limit 1); thymus: 27.8 nTPM (manageable, limit 5); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); lung: 20.9 nTPM (vital, limit 1); esophagus: 18.5 nTPM (protected, limit 3); urinary bladder: 17.8 nTPM (protected, limit 3); salivary gland: 17.8 nTPM (protected, limit 3); thyroid gland: 16.7 nTPM (manageable, limit 5); colon: 16.3 nTPM (protected, limit 3); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); skin: 14.4 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 3); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 3); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184602,SNN,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 29.7845% (minimum 65%, Missing); adrenal gland: 45.1056% (minimum 75%, Missing); amygdala: 17.1533% (minimum 75%, Missing); basal ganglia: 12.2587% (minimum 75%, Missing); bone marrow: 49.2662% (minimum 75%, Missing); cerebellum: 20.5420% (minimum 75%, Missing); cerebral cortex: 14.6875% (minimum 75%, Missing); choroid plexus: 61.6798% (minimum 75%, Missing); colon: 59.0452% (minimum 70%, Missing); duodenum: 72.7554% (minimum 75%, Missing); esophagus: 55.9524% (minimum 70%, Missing); heart muscle: 46.0784% (minimum 75%, Missing); hippocampal formation: 17.4074% (minimum 75%, Missing); hypothalamus: 30.4010% (minimum 75%, Missing); kidney: 62.6667% (minimum 75%, Missing); liver: 72.3077% (minimum 75%, Missing); lung: 52.9279% (minimum 75%, Missing); lymph node: 43.8433% (minimum 70%, Missing); midbrain: 17.7761% (minimum 75%, Missing); pancreas: 73.6677% (minimum 75%, Missing); pituitary gland: 61.0390% (minimum 75%, Missing); retina: 37.4204% (minimum 75%, Missing); salivary gland: 56.9007% (minimum 70%, Missing); skeletal muscle: 17.4981% (minimum 75%, Missing); skin: 62.0053% (minimum 65%, Missing); small intestine: 62.6667% (minimum 75%, Missing); smooth muscle: 69.7329% (minimum 75%, Missing); spinal cord: 31.1258% (minimum 75%, Missing); spleen: 41.0839% (minimum 65%, Missing); stomach: 63.3423% (minimum 70%, Missing); thymus: 45.8090% (minimum 65%, Missing); thyroid gland: 58.4577% (minimum 65%, Missing); tongue: 39.8305% (minimum 70%, Missing); urinary bladder: 56.9007% (minimum 70%, Missing)",-0.352155,-0.301695,-0.627413,0,2,partial,168.2,35.5,55.4,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (manageable, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 3); spleen: 33.7 nTPM (manageable, limit 5); lymph node: 30.1 nTPM (protected, limit 3); adrenal gland: 28.6 nTPM (vital, limit 1); thymus: 27.8 nTPM (manageable, limit 5); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); lung: 20.9 nTPM (vital, limit 1); esophagus: 18.5 nTPM (protected, limit 3); urinary bladder: 17.8 nTPM (protected, limit 3); salivary gland: 17.8 nTPM (protected, limit 3); thyroid gland: 16.7 nTPM (manageable, limit 5); colon: 16.3 nTPM (protected, limit 3); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); skin: 14.4 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 3); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 3); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184602,SNN,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 29.7845% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 45.1056% (minimum 75%, Baseline (adaptation disabled)); amygdala: 17.1533% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 12.2587% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 49.2662% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 20.5420% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 14.6875% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 61.6798% (minimum 75%, Baseline (adaptation disabled)); colon: 59.0452% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.7554% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.9524% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 46.0784% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 17.4074% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 30.4010% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 72.3077% (minimum 75%, Baseline (adaptation disabled)); lung: 52.9279% (minimum 75%, Baseline (adaptation disabled)); lymph node: 43.8433% (minimum 70%, Baseline (adaptation disabled)); midbrain: 17.7761% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.6677% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 61.0390% (minimum 75%, Baseline (adaptation disabled)); retina: 37.4204% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.9007% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 17.4981% (minimum 75%, Baseline (adaptation disabled)); skin: 62.0053% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.6667% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 69.7329% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 31.1258% (minimum 75%, Baseline (adaptation disabled)); spleen: 41.0839% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.3423% (minimum 70%, Baseline (adaptation disabled)); thymus: 45.8090% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.4577% (minimum 65%, Baseline (adaptation disabled)); tongue: 39.8305% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.9007% (minimum 70%, Baseline (adaptation disabled))",-0.352155,-0.301695,-0.627413,0,2,partial,168.2,35.5,55.4,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (manageable, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 3); spleen: 33.7 nTPM (manageable, limit 5); lymph node: 30.1 nTPM (protected, limit 3); adrenal gland: 28.6 nTPM (vital, limit 1); thymus: 27.8 nTPM (manageable, limit 5); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); lung: 20.9 nTPM (vital, limit 1); esophagus: 18.5 nTPM (protected, limit 3); urinary bladder: 17.8 nTPM (protected, limit 3); salivary gland: 17.8 nTPM (protected, limit 3); thyroid gland: 16.7 nTPM (manageable, limit 5); colon: 16.3 nTPM (protected, limit 3); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); skin: 14.4 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 3); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 3); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184602,SNN,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 86.4865% (minimum 99%, Missing); amygdala: 87.6712% (minimum 99%, Missing); basal ganglia: 81.0127% (minimum 99%, Missing); bone marrow: 68.0851% (minimum 99%, Missing); cerebellum: 85.3333% (minimum 99%, Missing); cerebral cortex: 75.2941% (minimum 99%, Missing); choroid plexus: 92.7536% (minimum 99%, Missing); colon: 77.1084% (minimum 97%, Missing); duodenum: 85.3333% (minimum 99%, Missing); esophagus: 82.0513% (minimum 97%, Missing); heart muscle: 84.2105% (minimum 99%, Missing); hippocampal formation: 87.6712% (minimum 99%, Missing); hypothalamus: 85.3333% (minimum 99%, Missing); kidney: 76.1905% (minimum 99%, Missing); liver: 86.4865% (minimum 99%, Missing); lung: 79.0123% (minimum 99%, Missing); lymph node: 56.6372% (minimum 97%, Missing); midbrain: 85.3333% (minimum 99%, Missing); pancreas: 68.0851% (minimum 99%, Missing); parathyroid gland: 78.0488% (minimum 97%, Missing); pituitary gland: 85.3333% (minimum 99%, Missing); rectum: 71.1111% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 77.1084% (minimum 97%, Missing); skeletal muscle: 79.0123% (minimum 99%, Missing); skin: 64.0000% (minimum 95%, Missing); small intestine: 81.0127% (minimum 99%, Missing); smooth muscle: 62.7451% (minimum 99%, Missing); spinal cord: 86.4865% (minimum 99%, Missing); spleen: 68.0851% (minimum 95%, Missing); stomach: 73.5632% (minimum 97%, Missing); thymus: 52.0325% (minimum 95%, Missing); thyroid gland: 48.8550% (minimum 95%, Missing); tongue: 81.0127% (minimum 97%, Missing); urinary bladder: 67.3684% (minimum 97%, Missing)",-0.46145,-0.403628,-0.362549,0,80,unavailable,3.8,4.9,6.7,"thyroid gland: 6.7 nTPM (manageable, limit 5); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 2); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184635,ZNF93,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 68.0851% (minimum 75%, Missing); lymph node: 56.6372% (minimum 70%, Missing); pancreas: 68.0851% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); skin: 64.0000% (minimum 65%, Missing); smooth muscle: 62.7451% (minimum 75%, Missing); thymus: 52.0325% (minimum 65%, Missing); thyroid gland: 48.8550% (minimum 65%, Missing); urinary bladder: 67.3684% (minimum 70%, Missing)",-0.16145,-0.133628,-0.122549,0,80,unavailable,3.8,4.9,6.7,"thyroid gland: 6.7 nTPM (manageable, limit 5); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 2); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184635,ZNF93,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 68.0851% (minimum 75%, Missing); lymph node: 56.6372% (minimum 70%, Missing); pancreas: 68.0851% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); skin: 64.0000% (minimum 65%, Missing); smooth muscle: 62.7451% (minimum 75%, Missing); thymus: 52.0325% (minimum 65%, Missing); thyroid gland: 48.8550% (minimum 65%, Missing); urinary bladder: 67.3684% (minimum 70%, Missing)",-0.16145,-0.133628,-0.122549,0,80,unavailable,3.8,4.9,6.7,"thyroid gland: 6.7 nTPM (manageable, limit 5); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 3); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184635,ZNF93,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 68.0851% (minimum 75%, Missing); lymph node: 56.6372% (minimum 70%, Missing); pancreas: 68.0851% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); skin: 64.0000% (minimum 65%, Missing); smooth muscle: 62.7451% (minimum 75%, Missing); thymus: 52.0325% (minimum 65%, Missing); thyroid gland: 48.8550% (minimum 65%, Missing); urinary bladder: 67.3684% (minimum 70%, Missing)",-0.16145,-0.133628,-0.122549,0,80,unavailable,3.8,4.9,6.7,"thyroid gland: 6.7 nTPM (manageable, limit 5); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 3); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184635,ZNF93,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 68.0851% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.6372% (minimum 70%, Baseline (adaptation disabled)); pancreas: 68.0851% (minimum 75%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 75%, Baseline (adaptation disabled)); skin: 64.0000% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 62.7451% (minimum 75%, Baseline (adaptation disabled)); thymus: 52.0325% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 48.8550% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 67.3684% (minimum 70%, Baseline (adaptation disabled))",-0.16145,-0.133628,-0.122549,0,80,unavailable,3.8,4.9,6.7,"thyroid gland: 6.7 nTPM (manageable, limit 5); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 3); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184635,ZNF93,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.5401% (minimum 99%, Missing); kidney: 98.5401% (minimum 99%, Missing)",0.05,0.03,-0.00459854,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184647,PRSS55,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235401,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184647,PRSS55,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235401,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184647,PRSS55,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235401,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184647,PRSS55,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235401,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184647,PRSS55,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184650,ODF4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184650,ODF4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184650,ODF4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184650,ODF4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184650,ODF4,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 74.7036% (minimum 99%, Missing); colon: 91.3043% (minimum 97%, Missing); duodenum: 92.6471% (minimum 99%, Missing); esophagus: 93.1034% (minimum 97%, Missing); lymph node: 78.7500% (minimum 97%, Missing); rectum: 90.0000% (minimum 97%, Missing); skin: 94.5000% (minimum 95%, Missing); small intestine: 91.3043% (minimum 99%, Missing); stomach: 95.9391% (minimum 97%, Missing); thymus: 63.0000% (minimum 95%, Missing)",-0.32,-0.1825,-0.242964,0,13,partial,6.4,5.1,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184661,CDCA2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 74.7036% (minimum 75%, Missing); thymus: 63.0000% (minimum 65%, Missing)",-0.02,0.0875,-0.00296443,0,13,partial,6.4,5.1,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184661,CDCA2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 74.7036% (minimum 75%, Missing); thymus: 63.0000% (minimum 65%, Missing)",-0.02,0.0875,-0.00296443,0,13,partial,6.4,5.1,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184661,CDCA2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 74.7036% (minimum 75%, Missing); thymus: 63.0000% (minimum 65%, Missing)",-0.02,0.0875,-0.00296443,0,13,partial,6.4,5.1,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184661,CDCA2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 74.7036% (minimum 75%, Baseline (adaptation disabled)); thymus: 63.0000% (minimum 65%, Baseline (adaptation disabled))",-0.02,0.0875,-0.00296443,0,13,partial,6.4,5.1,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184661,CDCA2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.9672% (minimum 95%, Missing); adrenal gland: 78.1250% (minimum 99%, Missing); amygdala: 92.5926% (minimum 99%, Missing); basal ganglia: 87.7193% (minimum 99%, Missing); bone marrow: 81.9672% (minimum 99%, Missing); cerebellum: 72.4638% (minimum 99%, Missing); cerebral cortex: 83.3333% (minimum 99%, Missing); choroid plexus: 94.3396% (minimum 99%, Missing); colon: 76.9231% (minimum 97%, Missing); duodenum: 78.1250% (minimum 99%, Missing); esophagus: 64.9351% (minimum 97%, Missing); heart muscle: 79.3651% (minimum 99%, Missing); hippocampal formation: 92.5926% (minimum 99%, Missing); hypothalamus: 89.2857% (minimum 99%, Missing); kidney: 74.6269% (minimum 99%, Missing); liver: 70.4225% (minimum 99%, Missing); lung: 80.6452% (minimum 99%, Missing); lymph node: 80.6452% (minimum 97%, Missing); midbrain: 92.5926% (minimum 99%, Missing); pancreas: 71.4286% (minimum 99%, Missing); parathyroid gland: 75.7576% (minimum 95%, Approved); pituitary gland: 87.7193% (minimum 99%, Missing); rectum: 79.3651% (minimum 97%, Missing); retina: 80.6452% (minimum 99%, Missing); salivary gland: 70.4225% (minimum 97%, Missing); skeletal muscle: 56.1798% (minimum 99%, Missing); skin: 70.4225% (minimum 95%, Missing); small intestine: 79.3651% (minimum 99%, Missing); smooth muscle: 64.9351% (minimum 99%, Missing); spinal cord: 94.3396% (minimum 99%, Missing); spleen: 79.3651% (minimum 95%, Missing); stomach: 75.7576% (minimum 97%, Missing); thymus: 76.9231% (minimum 95%, Missing); thyroid gland: 78.1250% (minimum 95%, Missing); tongue: 25.3807% (minimum 97%, Missing); urinary bladder: 80.6452% (minimum 97%, Missing)",-0.245775,-0.716193,-0.428202,0,0,routine_complete,3.9,14.7,2.1,"tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184675,AMER1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 72.4638% (minimum 75%, Missing); esophagus: 64.9351% (minimum 70%, Missing); kidney: 74.6269% (minimum 75%, Missing); liver: 70.4225% (minimum 75%, Missing); pancreas: 71.4286% (minimum 75%, Missing); skeletal muscle: 56.1798% (minimum 75%, Missing); smooth muscle: 64.9351% (minimum 75%, Missing); tongue: 25.3807% (minimum 70%, Missing)",0.0542254,-0.446193,-0.188202,0,0,routine_complete,3.9,14.7,2.1,"tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184675,AMER1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 72.4638% (minimum 75%, Missing); esophagus: 64.9351% (minimum 70%, Missing); kidney: 74.6269% (minimum 75%, Missing); liver: 70.4225% (minimum 75%, Missing); pancreas: 71.4286% (minimum 75%, Missing); skeletal muscle: 56.1798% (minimum 75%, Missing); smooth muscle: 64.9351% (minimum 75%, Missing); tongue: 25.3807% (minimum 70%, Missing)",0.0542254,-0.446193,-0.188202,0,0,routine_complete,3.9,14.7,2.1,"tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 3.9 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184675,AMER1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 72.4638% (minimum 75%, Missing); esophagus: 64.9351% (minimum 70%, Missing); kidney: 74.6269% (minimum 75%, Missing); liver: 70.4225% (minimum 75%, Missing); pancreas: 71.4286% (minimum 75%, Missing); skeletal muscle: 56.1798% (minimum 75%, Missing); smooth muscle: 64.9351% (minimum 75%, Missing); tongue: 25.3807% (minimum 70%, Missing)",0.0542254,-0.446193,-0.188202,0,0,routine_complete,3.9,14.7,2.1,"tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 3.9 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184675,AMER1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 72.4638% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.9351% (minimum 70%, Baseline (adaptation disabled)); kidney: 74.6269% (minimum 75%, Baseline (adaptation disabled)); liver: 70.4225% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.4286% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 56.1798% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.9351% (minimum 75%, Baseline (adaptation disabled)); tongue: 25.3807% (minimum 70%, Baseline (adaptation disabled))",0.0542254,-0.446193,-0.188202,0,0,routine_complete,3.9,14.7,2.1,"tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 3.9 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184675,AMER1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 92.3077% (minimum 99%, Missing); basal ganglia: 92.3077% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 99%, Missing); cerebral cortex: 92.3077% (minimum 99%, Missing); choroid plexus: 25.5319% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); midbrain: 85.7143% (minimum 99%, Missing); retina: 7.4534% (minimum 99%, Missing); spinal cord: 85.7143% (minimum 99%, Missing)",0.05,0.03,-0.915466,0,80,unavailable,14.9,0,0,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184716,SERINC4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 25.5319% (minimum 75%, Missing); retina: 7.4534% (minimum 75%, Missing)",0.35,0.3,-0.675466,0,80,unavailable,14.9,0,0,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184716,SERINC4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 25.5319% (minimum 75%, Missing); retina: 7.4534% (minimum 75%, Missing)",0.35,0.3,-0.675466,0,80,unavailable,14.9,0,0,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184716,SERINC4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 25.5319% (minimum 75%, Missing); retina: 7.4534% (minimum 75%, Missing)",0.35,0.3,-0.675466,0,80,unavailable,14.9,0,0,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184716,SERINC4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 25.5319% (minimum 75%, Baseline (adaptation disabled)); retina: 7.4534% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.675466,0,80,unavailable,14.9,0,0,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184716,SERINC4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184724,KRTAP6-1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184724,KRTAP6-1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184724,KRTAP6-1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184724,KRTAP6-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000184724,KRTAP6-1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184735,DDX53,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184735,DDX53,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184735,DDX53,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184735,DDX53,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184735,DDX53,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00438202,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184786,DYNLT2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.244382,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184786,DYNLT2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.244382,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184786,DYNLT2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.244382,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184786,DYNLT2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.244382,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184786,DYNLT2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184814,PRR23B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184814,PRR23B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184814,PRR23B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184814,PRR23B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184814,PRR23B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 78.3784% (minimum 99%, Missing); amygdala: 29.2929% (minimum 99%, Missing); basal ganglia: 23.5772% (minimum 99%, Missing); bone marrow: 94.5652% (minimum 99%, Missing); cerebellum: 48.0663% (minimum 99%, Missing); cerebral cortex: 27.2727% (minimum 99%, Missing); choroid plexus: 66.9231% (minimum 99%, Missing); colon: 90.6250% (minimum 97%, Missing); duodenum: 97.7528% (minimum 99%, Missing); heart muscle: 97.7528% (minimum 99%, Missing); hippocampal formation: 33.4615% (minimum 99%, Missing); hypothalamus: 24.3697% (minimum 99%, Missing); kidney: 87.0000% (minimum 99%, Missing); lung: 93.5484% (minimum 99%, Missing); lymph node: 91.5789% (minimum 97%, Missing); midbrain: 48.6034% (minimum 99%, Missing); pancreas: 74.3590% (minimum 99%, Missing); parathyroid gland: 90.6250% (minimum 97%, Missing); pituitary gland: 26.1261% (minimum 99%, Missing); rectum: 96.6667% (minimum 97%, Missing); retina: 52.0958% (minimum 99%, Missing); salivary gland: 91.5789% (minimum 97%, Missing); skeletal muscle: 98.8636% (minimum 99%, Missing); skin: 94.5652% (minimum 95%, Missing); small intestine: 89.6907% (minimum 99%, Missing); smooth muscle: 97.7528% (minimum 99%, Missing); spinal cord: 69.0476% (minimum 99%, Missing); spleen: 90.6250% (minimum 95%, Missing); stomach: 90.6250% (minimum 97%, Missing); thymus: 94.5652% (minimum 95%, Missing); thyroid gland: 73.1092% (minimum 95%, Missing); urinary bladder: 96.6667% (minimum 97%, Missing)",-0.218908,-0.06375,-0.754228,0,80,unavailable,28.2,0.9,3.2,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184911,DMRTC1B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 29.2929% (minimum 75%, Missing); basal ganglia: 23.5772% (minimum 75%, Missing); cerebellum: 48.0663% (minimum 75%, Missing); cerebral cortex: 27.2727% (minimum 75%, Missing); choroid plexus: 66.9231% (minimum 75%, Missing); hippocampal formation: 33.4615% (minimum 75%, Missing); hypothalamus: 24.3697% (minimum 75%, Missing); midbrain: 48.6034% (minimum 75%, Missing); pancreas: 74.3590% (minimum 75%, Missing); pituitary gland: 26.1261% (minimum 75%, Missing); retina: 52.0958% (minimum 75%, Missing); spinal cord: 69.0476% (minimum 75%, Missing)",0.0810924,0.20625,-0.514228,0,80,unavailable,28.2,0.9,3.2,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184911,DMRTC1B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 29.2929% (minimum 75%, Missing); basal ganglia: 23.5772% (minimum 75%, Missing); cerebellum: 48.0663% (minimum 75%, Missing); cerebral cortex: 27.2727% (minimum 75%, Missing); choroid plexus: 66.9231% (minimum 75%, Missing); hippocampal formation: 33.4615% (minimum 75%, Missing); hypothalamus: 24.3697% (minimum 75%, Missing); midbrain: 48.6034% (minimum 75%, Missing); pancreas: 74.3590% (minimum 75%, Missing); pituitary gland: 26.1261% (minimum 75%, Missing); retina: 52.0958% (minimum 75%, Missing); spinal cord: 69.0476% (minimum 75%, Missing)",0.0810924,0.20625,-0.514228,0,80,unavailable,28.2,0.9,3.2,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184911,DMRTC1B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 29.2929% (minimum 75%, Missing); basal ganglia: 23.5772% (minimum 75%, Missing); cerebellum: 48.0663% (minimum 75%, Missing); cerebral cortex: 27.2727% (minimum 75%, Missing); choroid plexus: 66.9231% (minimum 75%, Missing); hippocampal formation: 33.4615% (minimum 75%, Missing); hypothalamus: 24.3697% (minimum 75%, Missing); midbrain: 48.6034% (minimum 75%, Missing); pancreas: 74.3590% (minimum 75%, Missing); pituitary gland: 26.1261% (minimum 75%, Missing); retina: 52.0958% (minimum 75%, Missing); spinal cord: 69.0476% (minimum 75%, Missing)",0.0810924,0.20625,-0.514228,0,80,unavailable,28.2,0.9,3.2,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184911,DMRTC1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 29.2929% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 23.5772% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.0663% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 27.2727% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.9231% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 33.4615% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 24.3697% (minimum 75%, Baseline (adaptation disabled)); midbrain: 48.6034% (minimum 75%, Baseline (adaptation disabled)); pancreas: 74.3590% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 26.1261% (minimum 75%, Baseline (adaptation disabled)); retina: 52.0958% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.0476% (minimum 75%, Baseline (adaptation disabled))",0.0810924,0.20625,-0.514228,0,80,unavailable,28.2,0.9,3.2,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184911,DMRTC1B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184933,OR6A2,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184933,OR6A2,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184933,OR6A2,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184933,OR6A2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000184933,OR6A2,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 16.9811% (minimum 98%, Approved); cerebral cortex: 90.0000% (minimum 98%, Approved); colon: 64.2857% (minimum 97%, Missing); duodenum: 29.0323% (minimum 98%, Approved); pancreas: 29.0323% (minimum 99%, Missing); pituitary gland: 90.0000% (minimum 99%, Missing); rectum: 42.8571% (minimum 97%, Missing); salivary gland: 81.8182% (minimum 95%, Approved); small intestine: 42.8571% (minimum 99%, Missing); stomach: 12.5000% (minimum 97%, Missing)",0.05,-0.845,-0.810189,0,2,partial,4.4,6.3,0,"stomach: 6.3 nTPM (protected, limit 2); adrenal gland: 4.4 nTPM (vital, limit 2); duodenum: 2.2 nTPM (vital, limit 2); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185002,RFX6,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 16.9811% (minimum 70%, Approved); colon: 64.2857% (minimum 70%, Missing); duodenum: 29.0323% (minimum 70%, Approved); pancreas: 29.0323% (minimum 75%, Missing); rectum: 42.8571% (minimum 70%, Missing); small intestine: 42.8571% (minimum 75%, Missing); stomach: 12.5000% (minimum 70%, Missing)",0.35,-0.575,-0.530189,0,2,partial,4.4,6.3,0,"stomach: 6.3 nTPM (protected, limit 2); adrenal gland: 4.4 nTPM (vital, limit 2); duodenum: 2.2 nTPM (vital, limit 2); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185002,RFX6,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 16.9811% (minimum 70%, Approved); colon: 64.2857% (minimum 70%, Missing); duodenum: 29.0323% (minimum 70%, Approved); pancreas: 29.0323% (minimum 75%, Missing); rectum: 42.8571% (minimum 70%, Missing); small intestine: 42.8571% (minimum 75%, Missing); stomach: 12.5000% (minimum 70%, Missing)",0.35,-0.575,-0.530189,0,2,partial,4.4,6.3,0,"stomach: 6.3 nTPM (protected, limit 3); adrenal gland: 4.4 nTPM (vital, limit 2); duodenum: 2.2 nTPM (vital, limit 2); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185002,RFX6,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 16.9811% (minimum 70%, Approved); colon: 64.2857% (minimum 70%, Missing); duodenum: 29.0323% (minimum 70%, Approved); pancreas: 29.0323% (minimum 75%, Missing); rectum: 42.8571% (minimum 70%, Missing); small intestine: 42.8571% (minimum 75%, Missing); stomach: 12.5000% (minimum 70%, Missing)",0.35,-0.575,-0.530189,0,2,partial,4.4,6.3,0,"stomach: 6.3 nTPM (protected, limit 3); adrenal gland: 4.4 nTPM (vital, limit 2); duodenum: 2.2 nTPM (vital, limit 2); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185002,RFX6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 16.9811% (minimum 75%, Baseline (adaptation disabled)); colon: 64.2857% (minimum 70%, Baseline (adaptation disabled)); duodenum: 29.0323% (minimum 75%, Baseline (adaptation disabled)); pancreas: 29.0323% (minimum 75%, Baseline (adaptation disabled)); rectum: 42.8571% (minimum 70%, Baseline (adaptation disabled)); small intestine: 42.8571% (minimum 75%, Baseline (adaptation disabled)); stomach: 12.5000% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.575,-0.580189,0,2,partial,4.4,6.3,0,"stomach: 6.3 nTPM (protected, limit 3); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185002,RFX6,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.5714% (minimum 99%, Missing); bone marrow: 98.8539% (minimum 99%, Missing); duodenum: 98.0114% (minimum 99%, Missing); heart muscle: 98.2906% (minimum 99%, Missing); pancreas: 98.8539% (minimum 99%, Missing)",0.021831,0.00457627,-0.00988636,0,80,unavailable,0.7,0.9,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185013,NT5C1B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321831,0.274576,0.230114,0,80,unavailable,0.7,0.9,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185013,NT5C1B,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321831,0.274576,0.230114,0,80,unavailable,0.7,0.9,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185013,NT5C1B,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321831,0.274576,0.230114,0,80,unavailable,0.7,0.9,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185013,NT5C1B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321831,0.274576,0.230114,0,80,unavailable,0.7,0.9,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185013,NT5C1B,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.3069% (minimum 95%, Enhanced); amygdala: 13.5397% (minimum 99%, Missing); basal ganglia: 9.3085% (minimum 99%, Missing); cerebellum: 22.7273% (minimum 95%, Enhanced); cerebral cortex: 9.9291% (minimum 95%, Enhanced); choroid plexus: 67.3077% (minimum 99%, Missing); colon: 64.8148% (minimum 97%, Missing); duodenum: 94.5946% (minimum 99%, Missing); esophagus: 73.6842% (minimum 80%, Enhanced); heart muscle: 83.3333% (minimum 95%, Enhanced); hippocampal formation: 10.4012% (minimum 99%, Missing); hypothalamus: 15.9091% (minimum 99%, Missing); kidney: 61.9469% (minimum 95%, Enhanced); liver: 86.4198% (minimum 95%, Enhanced); lung: 89.7436% (minimum 95%, Enhanced); midbrain: 15.4867% (minimum 99%, Missing); pancreas: 86.4198% (minimum 95%, Enhanced); pituitary gland: 41.6667% (minimum 99%, Missing); rectum: 88.6076% (minimum 97%, Missing); retina: 54.2636% (minimum 99%, Missing); salivary gland: 73.6842% (minimum 80%, Enhanced); skeletal muscle: 30.7018% (minimum 95%, Enhanced); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 78.6517% (minimum 95%, Enhanced); spinal cord: 10.4167% (minimum 99%, Missing); thymus: 88.6076% (minimum 95%, Missing); tongue: 82.3529% (minimum 97%, Missing); urinary bladder: 77.7778% (minimum 80%, Enhanced)",-0.0639241,-0.321852,-0.896915,0,10,partial,68.2,3.8,4.6,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 6); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 6); skeletal muscle: 15.8 nTPM (vital, limit 6); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185046,ANKS1B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 13.5397% (minimum 75%, Missing); basal ganglia: 9.3085% (minimum 75%, Missing); cerebellum: 22.7273% (minimum 60%, Enhanced); cerebral cortex: 9.9291% (minimum 60%, Enhanced); choroid plexus: 67.3077% (minimum 75%, Missing); colon: 64.8148% (minimum 70%, Missing); hippocampal formation: 10.4012% (minimum 75%, Missing); hypothalamus: 15.9091% (minimum 75%, Missing); midbrain: 15.4867% (minimum 75%, Missing); pituitary gland: 41.6667% (minimum 75%, Missing); retina: 54.2636% (minimum 75%, Missing); skeletal muscle: 30.7018% (minimum 60%, Enhanced); spinal cord: 10.4167% (minimum 75%, Missing)",0.103448,-0.0518519,-0.656915,0,10,partial,68.2,3.8,4.6,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 6); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 6); skeletal muscle: 15.8 nTPM (vital, limit 6); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185046,ANKS1B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 13.5397% (minimum 75%, Missing); basal ganglia: 9.3085% (minimum 75%, Missing); cerebellum: 22.7273% (minimum 60%, Enhanced); cerebral cortex: 9.9291% (minimum 60%, Enhanced); choroid plexus: 67.3077% (minimum 75%, Missing); colon: 64.8148% (minimum 70%, Missing); hippocampal formation: 10.4012% (minimum 75%, Missing); hypothalamus: 15.9091% (minimum 75%, Missing); midbrain: 15.4867% (minimum 75%, Missing); pituitary gland: 41.6667% (minimum 75%, Missing); retina: 54.2636% (minimum 75%, Missing); skeletal muscle: 30.7018% (minimum 60%, Enhanced); spinal cord: 10.4167% (minimum 75%, Missing)",0.103448,-0.0518519,-0.656915,0,10,partial,68.2,3.8,4.6,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 6); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 6); skeletal muscle: 15.8 nTPM (vital, limit 6); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); choroid plexus: 3.4 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185046,ANKS1B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 13.5397% (minimum 75%, Missing); basal ganglia: 9.3085% (minimum 75%, Missing); cerebellum: 22.7273% (minimum 60%, Enhanced); cerebral cortex: 9.9291% (minimum 60%, Enhanced); choroid plexus: 67.3077% (minimum 75%, Missing); colon: 64.8148% (minimum 70%, Missing); hippocampal formation: 10.4012% (minimum 75%, Missing); hypothalamus: 15.9091% (minimum 75%, Missing); midbrain: 15.4867% (minimum 75%, Missing); pituitary gland: 41.6667% (minimum 75%, Missing); retina: 54.2636% (minimum 75%, Missing); skeletal muscle: 30.7018% (minimum 60%, Enhanced); spinal cord: 10.4167% (minimum 75%, Missing)",0.103448,-0.0518519,-0.656915,0,10,partial,68.2,3.8,4.6,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 6); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 6); skeletal muscle: 15.8 nTPM (vital, limit 6); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); choroid plexus: 3.4 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185046,ANKS1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.3069% (minimum 75%, Baseline (adaptation disabled)); amygdala: 13.5397% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 9.3085% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 22.7273% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 9.9291% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.3077% (minimum 75%, Baseline (adaptation disabled)); colon: 64.8148% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 10.4012% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 15.9091% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.9469% (minimum 75%, Baseline (adaptation disabled)); midbrain: 15.4867% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 41.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 54.2636% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 30.7018% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 10.4167% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 60.3448% (minimum 65%, Baseline (adaptation disabled))",-0.0465517,-0.0518519,-0.656915,0,10,partial,68.2,3.8,4.6,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); skeletal muscle: 15.8 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185046,ANKS1B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2877% (minimum 99%, Missing); amygdala: 94.0984% (minimum 99%, Missing); basal ganglia: 89.4081% (minimum 99%, Missing); bone marrow: 92.5806% (minimum 99%, Missing); cerebellum: 97.6190% (minimum 99%, Missing); cerebral cortex: 94.0984% (minimum 99%, Missing); choroid plexus: 69.8297% (minimum 99%, Missing); duodenum: 98.6254% (minimum 99%, Missing); heart muscle: 98.2877% (minimum 99%, Missing); hippocampal formation: 91.4013% (minimum 99%, Missing); hypothalamus: 89.6875% (minimum 99%, Missing); kidney: 96.9595% (minimum 99%, Missing); liver: 96.6330% (minimum 99%, Missing); lung: 90.2516% (minimum 99%, Missing); midbrain: 97.2881% (minimum 99%, Missing); pancreas: 95.3488% (minimum 99%, Missing); pituitary gland: 93.1818% (minimum 99%, Missing); retina: 95.6667% (minimum 99%, Missing); skeletal muscle: 95.9866% (minimum 99%, Missing); small intestine: 97.6190% (minimum 99%, Missing); spinal cord: 95.9866% (minimum 99%, Missing)",0.0130872,0.00288136,-0.291703,0,80,unavailable,12.4,0.8,1.1,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185055,EFCAB10,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 69.8297% (minimum 75%, Missing)",0.313087,0.272881,-0.0517032,0,80,unavailable,12.4,0.8,1.1,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185055,EFCAB10,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 69.8297% (minimum 75%, Missing)",0.313087,0.272881,-0.0517032,0,80,unavailable,12.4,0.8,1.1,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185055,EFCAB10,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 69.8297% (minimum 75%, Missing)",0.313087,0.272881,-0.0517032,0,80,unavailable,12.4,0.8,1.1,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185055,EFCAB10,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 69.8297% (minimum 75%, Baseline (adaptation disabled))",0.313087,0.272881,-0.0517032,0,80,unavailable,12.4,0.8,1.1,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185055,EFCAB10,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.05,0.03,0.000566038,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185056,C5orf47,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240566,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185056,C5orf47,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240566,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185056,C5orf47,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240566,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185056,C5orf47,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240566,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185056,C5orf47,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 69.4118% (minimum 95%, Missing); adrenal gland: 69.4118% (minimum 99%, Missing); amygdala: 66.2921% (minimum 99%, Missing); basal ganglia: 63.4409% (minimum 99%, Missing); bone marrow: 60.2041% (minimum 99%, Missing); cerebellum: 50.4274% (minimum 99%, Missing); cerebral cortex: 57.8431% (minimum 99%, Missing); choroid plexus: 70.2381% (minimum 99%, Missing); colon: 59.5960% (minimum 97%, Missing); duodenum: 71.0843% (minimum 99%, Missing); esophagus: 60.2041% (minimum 97%, Missing); heart muscle: 47.2000% (minimum 99%, Missing); hippocampal formation: 65.5556% (minimum 99%, Missing); hypothalamus: 63.4409% (minimum 99%, Missing); kidney: 60.2041% (minimum 99%, Missing); liver: 65.5556% (minimum 98%, Approved); lung: 67.8161% (minimum 99%, Missing); lymph node: 67.0455% (minimum 97%, Missing); midbrain: 68.6047% (minimum 99%, Missing); pancreas: 60.2041% (minimum 99%, Missing); parathyroid gland: 50.4274% (minimum 97%, Missing); pituitary gland: 67.8161% (minimum 99%, Missing); rectum: 62.1053% (minimum 97%, Missing); retina: 46.0938% (minimum 99%, Missing); salivary gland: 66.2921% (minimum 97%, Missing); skeletal muscle: 33.3333% (minimum 99%, Missing); skin: 59.5960% (minimum 95%, Missing); small intestine: 68.6047% (minimum 99%, Missing); smooth muscle: 59.5960% (minimum 99%, Missing); spinal cord: 68.6047% (minimum 99%, Missing); spleen: 71.9512% (minimum 95%, Missing); stomach: 70.2381% (minimum 97%, Missing); thymus: 56.1905% (minimum 95%, Missing); thyroid gland: 56.1905% (minimum 95%, Missing); tongue: 39.5973% (minimum 97%, Missing); urinary bladder: 64.1304% (minimum 97%, Missing)",-0.388095,-0.574027,-0.656667,0,8,partial,11.8,9,4.6,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); cerebral cortex: 4.3 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185104,FAF1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.4118% (minimum 75%, Missing); amygdala: 66.2921% (minimum 75%, Missing); basal ganglia: 63.4409% (minimum 75%, Missing); bone marrow: 60.2041% (minimum 75%, Missing); cerebellum: 50.4274% (minimum 75%, Missing); cerebral cortex: 57.8431% (minimum 75%, Missing); choroid plexus: 70.2381% (minimum 75%, Missing); colon: 59.5960% (minimum 70%, Missing); duodenum: 71.0843% (minimum 75%, Missing); esophagus: 60.2041% (minimum 70%, Missing); heart muscle: 47.2000% (minimum 75%, Missing); hippocampal formation: 65.5556% (minimum 75%, Missing); hypothalamus: 63.4409% (minimum 75%, Missing); kidney: 60.2041% (minimum 75%, Missing); liver: 65.5556% (minimum 70%, Approved); lung: 67.8161% (minimum 75%, Missing); lymph node: 67.0455% (minimum 70%, Missing); midbrain: 68.6047% (minimum 75%, Missing); pancreas: 60.2041% (minimum 75%, Missing); parathyroid gland: 50.4274% (minimum 70%, Missing); pituitary gland: 67.8161% (minimum 75%, Missing); rectum: 62.1053% (minimum 70%, Missing); retina: 46.0938% (minimum 75%, Missing); salivary gland: 66.2921% (minimum 70%, Missing); skeletal muscle: 33.3333% (minimum 75%, Missing); skin: 59.5960% (minimum 65%, Missing); small intestine: 68.6047% (minimum 75%, Missing); smooth muscle: 59.5960% (minimum 75%, Missing); spinal cord: 68.6047% (minimum 75%, Missing); thymus: 56.1905% (minimum 65%, Missing); thyroid gland: 56.1905% (minimum 65%, Missing); tongue: 39.5973% (minimum 70%, Missing); urinary bladder: 64.1304% (minimum 70%, Missing)",-0.0880952,-0.304027,-0.416667,0,8,partial,11.8,9,4.6,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); cerebral cortex: 4.3 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185104,FAF1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.4118% (minimum 75%, Missing); amygdala: 66.2921% (minimum 75%, Missing); basal ganglia: 63.4409% (minimum 75%, Missing); bone marrow: 60.2041% (minimum 75%, Missing); cerebellum: 50.4274% (minimum 75%, Missing); cerebral cortex: 57.8431% (minimum 75%, Missing); choroid plexus: 70.2381% (minimum 75%, Missing); colon: 59.5960% (minimum 70%, Missing); duodenum: 71.0843% (minimum 75%, Missing); esophagus: 60.2041% (minimum 70%, Missing); heart muscle: 47.2000% (minimum 75%, Missing); hippocampal formation: 65.5556% (minimum 75%, Missing); hypothalamus: 63.4409% (minimum 75%, Missing); kidney: 60.2041% (minimum 75%, Missing); liver: 65.5556% (minimum 70%, Approved); lung: 67.8161% (minimum 75%, Missing); lymph node: 67.0455% (minimum 70%, Missing); midbrain: 68.6047% (minimum 75%, Missing); pancreas: 60.2041% (minimum 75%, Missing); parathyroid gland: 50.4274% (minimum 70%, Missing); pituitary gland: 67.8161% (minimum 75%, Missing); rectum: 62.1053% (minimum 70%, Missing); retina: 46.0938% (minimum 75%, Missing); salivary gland: 66.2921% (minimum 70%, Missing); skeletal muscle: 33.3333% (minimum 75%, Missing); skin: 59.5960% (minimum 65%, Missing); small intestine: 68.6047% (minimum 75%, Missing); smooth muscle: 59.5960% (minimum 75%, Missing); spinal cord: 68.6047% (minimum 75%, Missing); thymus: 56.1905% (minimum 65%, Missing); thyroid gland: 56.1905% (minimum 65%, Missing); tongue: 39.5973% (minimum 70%, Missing); urinary bladder: 64.1304% (minimum 70%, Missing)",-0.0880952,-0.304027,-0.416667,0,8,partial,11.8,9,4.6,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 3); cerebellum: 5.8 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); bone marrow: 3.9 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185104,FAF1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.4118% (minimum 75%, Missing); amygdala: 66.2921% (minimum 75%, Missing); basal ganglia: 63.4409% (minimum 75%, Missing); bone marrow: 60.2041% (minimum 75%, Missing); cerebellum: 50.4274% (minimum 75%, Missing); cerebral cortex: 57.8431% (minimum 75%, Missing); choroid plexus: 70.2381% (minimum 75%, Missing); colon: 59.5960% (minimum 70%, Missing); duodenum: 71.0843% (minimum 75%, Missing); esophagus: 60.2041% (minimum 70%, Missing); heart muscle: 47.2000% (minimum 75%, Missing); hippocampal formation: 65.5556% (minimum 75%, Missing); hypothalamus: 63.4409% (minimum 75%, Missing); kidney: 60.2041% (minimum 75%, Missing); liver: 65.5556% (minimum 70%, Approved); lung: 67.8161% (minimum 75%, Missing); lymph node: 67.0455% (minimum 70%, Missing); midbrain: 68.6047% (minimum 75%, Missing); pancreas: 60.2041% (minimum 75%, Missing); parathyroid gland: 50.4274% (minimum 70%, Missing); pituitary gland: 67.8161% (minimum 75%, Missing); rectum: 62.1053% (minimum 70%, Missing); retina: 46.0938% (minimum 75%, Missing); salivary gland: 66.2921% (minimum 70%, Missing); skeletal muscle: 33.3333% (minimum 75%, Missing); skin: 59.5960% (minimum 65%, Missing); small intestine: 68.6047% (minimum 75%, Missing); smooth muscle: 59.5960% (minimum 75%, Missing); spinal cord: 68.6047% (minimum 75%, Missing); thymus: 56.1905% (minimum 65%, Missing); thyroid gland: 56.1905% (minimum 65%, Missing); tongue: 39.5973% (minimum 70%, Missing); urinary bladder: 64.1304% (minimum 70%, Missing)",-0.0880952,-0.304027,-0.416667,0,8,partial,11.8,9,4.6,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 3); cerebellum: 5.8 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); bone marrow: 3.9 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185104,FAF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.4118% (minimum 75%, Baseline (adaptation disabled)); amygdala: 66.2921% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 63.4409% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 60.2041% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 50.4274% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.8431% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.2381% (minimum 75%, Baseline (adaptation disabled)); colon: 59.5960% (minimum 70%, Baseline (adaptation disabled)); duodenum: 71.0843% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.2041% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 47.2000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.5556% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.4409% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.2041% (minimum 75%, Baseline (adaptation disabled)); liver: 65.5556% (minimum 75%, Baseline (adaptation disabled)); lung: 67.8161% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.0455% (minimum 70%, Baseline (adaptation disabled)); midbrain: 68.6047% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.2041% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.4274% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.8161% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.1053% (minimum 70%, Baseline (adaptation disabled)); retina: 46.0938% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.2921% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 33.3333% (minimum 75%, Baseline (adaptation disabled)); skin: 59.5960% (minimum 65%, Baseline (adaptation disabled)); small intestine: 68.6047% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.5960% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.6047% (minimum 75%, Baseline (adaptation disabled)); thymus: 56.1905% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.1905% (minimum 65%, Baseline (adaptation disabled)); tongue: 39.5973% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 64.1304% (minimum 70%, Baseline (adaptation disabled))",-0.0880952,-0.304027,-0.416667,0,8,partial,11.8,9,4.6,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 3); cerebellum: 5.8 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); bone marrow: 3.9 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185104,FAF1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 90.5109% (minimum 97%, Missing); duodenum: 91.5129% (minimum 99%, Missing); kidney: 93.9394% (minimum 99%, Missing); lung: 98.8048% (minimum 99%, Missing); pancreas: 73.1563% (minimum 99%, Missing); parathyroid gland: 86.1111% (minimum 97%, Missing); pituitary gland: 84.0678% (minimum 99%, Missing); rectum: 89.2086% (minimum 97%, Missing); salivary gland: 78.9809% (minimum 97%, Missing); small intestine: 94.2966% (minimum 99%, Missing); stomach: 86.4111% (minimum 97%, Missing); thyroid gland: 88.2562% (minimum 95%, Missing)",-0.0674377,-0.180191,-0.258437,0,80,unavailable,9.1,6.6,3.3,"pancreas: 9.1 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); pituitary gland: 4.7 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); stomach: 3.9 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185156,MFSD6L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 73.1563% (minimum 75%, Missing)",0.232562,0.0898089,-0.0184366,0,80,unavailable,9.1,6.6,3.3,"pancreas: 9.1 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); pituitary gland: 4.7 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); stomach: 3.9 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185156,MFSD6L,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 73.1563% (minimum 75%, Missing)",0.232562,0.0898089,-0.0184366,0,80,unavailable,9.1,6.6,3.3,"pancreas: 9.1 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); pituitary gland: 4.7 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185156,MFSD6L,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 73.1563% (minimum 75%, Missing)",0.232562,0.0898089,-0.0184366,0,80,unavailable,9.1,6.6,3.3,"pancreas: 9.1 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); pituitary gland: 4.7 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185156,MFSD6L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 73.1563% (minimum 75%, Baseline (adaptation disabled))",0.232562,0.0898089,-0.0184366,0,80,unavailable,9.1,6.6,3.3,"pancreas: 9.1 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); pituitary gland: 4.7 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185156,MFSD6L,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.4286% (minimum 99%, Missing); retina: 96.4286% (minimum 99%, Missing)",0.0142857,0.03,-0.0257143,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185177,ZNF479,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.314286,0.3,0.214286,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185177,ZNF479,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.314286,0.3,0.214286,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185177,ZNF479,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.314286,0.3,0.214286,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185177,ZNF479,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.314286,0.3,0.214286,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185177,ZNF479,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.7046% (minimum 95%, Missing); adrenal gland: 54.0236% (minimum 99%, Missing); amygdala: 47.0714% (minimum 99%, Missing); basal ganglia: 44.4131% (minimum 99%, Missing); bone marrow: 61.9235% (minimum 99%, Missing); cerebellum: 44.2524% (minimum 99%, Missing); cerebral cortex: 44.2524% (minimum 99%, Missing); choroid plexus: 63.0946% (minimum 99%, Missing); colon: 53.4726% (minimum 97%, Missing); duodenum: 59.7072% (minimum 99%, Missing); esophagus: 54.3435% (minimum 97%, Missing); heart muscle: 40.3740% (minimum 99%, Missing); hippocampal formation: 45.5712% (minimum 99%, Missing); hypothalamus: 47.2938% (minimum 99%, Missing); kidney: 46.6921% (minimum 99%, Missing); liver: 45.7416% (minimum 99%, Missing); lung: 53.6288% (minimum 99%, Missing); lymph node: 65.7706% (minimum 97%, Missing); midbrain: 43.3124% (minimum 99%, Missing); pancreas: 46.6328% (minimum 99%, Missing); parathyroid gland: 69.9936% (minimum 97%, Missing); pituitary gland: 49.4165% (minimum 99%, Missing); rectum: 82.9691% (minimum 97%, Missing); retina: 74.8470% (minimum 99%, Missing); salivary gland: 52.1060% (minimum 97%, Missing); skeletal muscle: 48.8248% (minimum 99%, Missing); skin: 52.7552% (minimum 95%, Missing); small intestine: 53.8123% (minimum 99%, Missing); smooth muscle: 80.4237% (minimum 99%, Missing); spinal cord: 40.1972% (minimum 99%, Missing); spleen: 48.7384% (minimum 95%, Missing); stomach: 48.9987% (minimum 97%, Missing); thymus: 71.9608% (minimum 95%, Missing); thyroid gland: 35.0972% (minimum 95%, Missing); tongue: 75.6701% (minimum 97%, Missing); urinary bladder: 53.3689% (minimum 97%, Missing)",-0.599028,-0.480013,-0.588028,0,80,unavailable,163.8,114.6,203.6,"thyroid gland: 203.6 nTPM (manageable, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); spleen: 115.8 nTPM (manageable, limit 5); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 2); pituitary gland: 112.7 nTPM (vital, limit 1); salivary gland: 101.2 nTPM (protected, limit 2); adipose tissue: 98.8 nTPM (manageable, limit 5); skin: 98.6 nTPM (manageable, limit 5); urinary bladder: 96.2 nTPM (protected, limit 2); colon: 95.8 nTPM (protected, limit 2); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 2); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); lymph node: 57.3 nTPM (protected, limit 2); parathyroid gland: 47.2 nTPM (protected, limit 2); thymus: 42.9 nTPM (manageable, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 2); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185236,RAB11B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.7046% (minimum 65%, Missing); adrenal gland: 54.0236% (minimum 75%, Missing); amygdala: 47.0714% (minimum 75%, Missing); basal ganglia: 44.4131% (minimum 75%, Missing); bone marrow: 61.9235% (minimum 75%, Missing); cerebellum: 44.2524% (minimum 75%, Missing); cerebral cortex: 44.2524% (minimum 75%, Missing); choroid plexus: 63.0946% (minimum 75%, Missing); colon: 53.4726% (minimum 70%, Missing); duodenum: 59.7072% (minimum 75%, Missing); esophagus: 54.3435% (minimum 70%, Missing); heart muscle: 40.3740% (minimum 75%, Missing); hippocampal formation: 45.5712% (minimum 75%, Missing); hypothalamus: 47.2938% (minimum 75%, Missing); kidney: 46.6921% (minimum 75%, Missing); liver: 45.7416% (minimum 75%, Missing); lung: 53.6288% (minimum 75%, Missing); lymph node: 65.7706% (minimum 70%, Missing); midbrain: 43.3124% (minimum 75%, Missing); pancreas: 46.6328% (minimum 75%, Missing); parathyroid gland: 69.9936% (minimum 70%, Missing); pituitary gland: 49.4165% (minimum 75%, Missing); retina: 74.8470% (minimum 75%, Missing); salivary gland: 52.1060% (minimum 70%, Missing); skeletal muscle: 48.8248% (minimum 75%, Missing); skin: 52.7552% (minimum 65%, Missing); small intestine: 53.8123% (minimum 75%, Missing); spinal cord: 40.1972% (minimum 75%, Missing); spleen: 48.7384% (minimum 65%, Missing); stomach: 48.9987% (minimum 70%, Missing); thyroid gland: 35.0972% (minimum 65%, Missing); urinary bladder: 53.3689% (minimum 70%, Missing)",-0.299028,-0.210013,-0.348028,0,80,unavailable,163.8,114.6,203.6,"thyroid gland: 203.6 nTPM (manageable, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); spleen: 115.8 nTPM (manageable, limit 5); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 2); pituitary gland: 112.7 nTPM (vital, limit 1); salivary gland: 101.2 nTPM (protected, limit 2); adipose tissue: 98.8 nTPM (manageable, limit 5); skin: 98.6 nTPM (manageable, limit 5); urinary bladder: 96.2 nTPM (protected, limit 2); colon: 95.8 nTPM (protected, limit 2); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 2); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); lymph node: 57.3 nTPM (protected, limit 2); parathyroid gland: 47.2 nTPM (protected, limit 2); thymus: 42.9 nTPM (manageable, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 2); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185236,RAB11B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.7046% (minimum 65%, Missing); adrenal gland: 54.0236% (minimum 75%, Missing); amygdala: 47.0714% (minimum 75%, Missing); basal ganglia: 44.4131% (minimum 75%, Missing); bone marrow: 61.9235% (minimum 75%, Missing); cerebellum: 44.2524% (minimum 75%, Missing); cerebral cortex: 44.2524% (minimum 75%, Missing); choroid plexus: 63.0946% (minimum 75%, Missing); colon: 53.4726% (minimum 70%, Missing); duodenum: 59.7072% (minimum 75%, Missing); esophagus: 54.3435% (minimum 70%, Missing); heart muscle: 40.3740% (minimum 75%, Missing); hippocampal formation: 45.5712% (minimum 75%, Missing); hypothalamus: 47.2938% (minimum 75%, Missing); kidney: 46.6921% (minimum 75%, Missing); liver: 45.7416% (minimum 75%, Missing); lung: 53.6288% (minimum 75%, Missing); lymph node: 65.7706% (minimum 70%, Missing); midbrain: 43.3124% (minimum 75%, Missing); pancreas: 46.6328% (minimum 75%, Missing); parathyroid gland: 69.9936% (minimum 70%, Missing); pituitary gland: 49.4165% (minimum 75%, Missing); retina: 74.8470% (minimum 75%, Missing); salivary gland: 52.1060% (minimum 70%, Missing); skeletal muscle: 48.8248% (minimum 75%, Missing); skin: 52.7552% (minimum 65%, Missing); small intestine: 53.8123% (minimum 75%, Missing); spinal cord: 40.1972% (minimum 75%, Missing); spleen: 48.7384% (minimum 65%, Missing); stomach: 48.9987% (minimum 70%, Missing); thyroid gland: 35.0972% (minimum 65%, Missing); urinary bladder: 53.3689% (minimum 70%, Missing)",-0.299028,-0.210013,-0.348028,0,80,unavailable,163.8,114.6,203.6,"thyroid gland: 203.6 nTPM (manageable, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); spleen: 115.8 nTPM (manageable, limit 5); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 3); pituitary gland: 112.7 nTPM (vital, limit 1); salivary gland: 101.2 nTPM (protected, limit 3); adipose tissue: 98.8 nTPM (manageable, limit 5); skin: 98.6 nTPM (manageable, limit 5); urinary bladder: 96.2 nTPM (protected, limit 3); colon: 95.8 nTPM (protected, limit 3); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 3); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); lymph node: 57.3 nTPM (protected, limit 3); parathyroid gland: 47.2 nTPM (protected, limit 3); thymus: 42.9 nTPM (manageable, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 3); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185236,RAB11B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.7046% (minimum 65%, Missing); adrenal gland: 54.0236% (minimum 75%, Missing); amygdala: 47.0714% (minimum 75%, Missing); basal ganglia: 44.4131% (minimum 75%, Missing); bone marrow: 61.9235% (minimum 75%, Missing); cerebellum: 44.2524% (minimum 75%, Missing); cerebral cortex: 44.2524% (minimum 75%, Missing); choroid plexus: 63.0946% (minimum 75%, Missing); colon: 53.4726% (minimum 70%, Missing); duodenum: 59.7072% (minimum 75%, Missing); esophagus: 54.3435% (minimum 70%, Missing); heart muscle: 40.3740% (minimum 75%, Missing); hippocampal formation: 45.5712% (minimum 75%, Missing); hypothalamus: 47.2938% (minimum 75%, Missing); kidney: 46.6921% (minimum 75%, Missing); liver: 45.7416% (minimum 75%, Missing); lung: 53.6288% (minimum 75%, Missing); lymph node: 65.7706% (minimum 70%, Missing); midbrain: 43.3124% (minimum 75%, Missing); pancreas: 46.6328% (minimum 75%, Missing); parathyroid gland: 69.9936% (minimum 70%, Missing); pituitary gland: 49.4165% (minimum 75%, Missing); retina: 74.8470% (minimum 75%, Missing); salivary gland: 52.1060% (minimum 70%, Missing); skeletal muscle: 48.8248% (minimum 75%, Missing); skin: 52.7552% (minimum 65%, Missing); small intestine: 53.8123% (minimum 75%, Missing); spinal cord: 40.1972% (minimum 75%, Missing); spleen: 48.7384% (minimum 65%, Missing); stomach: 48.9987% (minimum 70%, Missing); thyroid gland: 35.0972% (minimum 65%, Missing); urinary bladder: 53.3689% (minimum 70%, Missing)",-0.299028,-0.210013,-0.348028,0,80,unavailable,163.8,114.6,203.6,"thyroid gland: 203.6 nTPM (manageable, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); spleen: 115.8 nTPM (manageable, limit 5); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 3); pituitary gland: 112.7 nTPM (vital, limit 1); salivary gland: 101.2 nTPM (protected, limit 3); adipose tissue: 98.8 nTPM (manageable, limit 5); skin: 98.6 nTPM (manageable, limit 5); urinary bladder: 96.2 nTPM (protected, limit 3); colon: 95.8 nTPM (protected, limit 3); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 3); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); lymph node: 57.3 nTPM (protected, limit 3); parathyroid gland: 47.2 nTPM (protected, limit 3); thymus: 42.9 nTPM (manageable, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 3); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185236,RAB11B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.7046% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 54.0236% (minimum 75%, Baseline (adaptation disabled)); amygdala: 47.0714% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 44.4131% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.9235% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 44.2524% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 44.2524% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 63.0946% (minimum 75%, Baseline (adaptation disabled)); colon: 53.4726% (minimum 70%, Baseline (adaptation disabled)); duodenum: 59.7072% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.3435% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 40.3740% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 45.5712% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 47.2938% (minimum 75%, Baseline (adaptation disabled)); kidney: 46.6921% (minimum 75%, Baseline (adaptation disabled)); liver: 45.7416% (minimum 75%, Baseline (adaptation disabled)); lung: 53.6288% (minimum 75%, Baseline (adaptation disabled)); lymph node: 65.7706% (minimum 70%, Baseline (adaptation disabled)); midbrain: 43.3124% (minimum 75%, Baseline (adaptation disabled)); pancreas: 46.6328% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.9936% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 49.4165% (minimum 75%, Baseline (adaptation disabled)); retina: 74.8470% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 52.1060% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 48.8248% (minimum 75%, Baseline (adaptation disabled)); skin: 52.7552% (minimum 65%, Baseline (adaptation disabled)); small intestine: 53.8123% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 40.1972% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.7384% (minimum 65%, Baseline (adaptation disabled)); stomach: 48.9987% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 35.0972% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 53.3689% (minimum 70%, Baseline (adaptation disabled))",-0.299028,-0.210013,-0.348028,0,80,unavailable,163.8,114.6,203.6,"thyroid gland: 203.6 nTPM (manageable, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); spleen: 115.8 nTPM (manageable, limit 5); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 3); pituitary gland: 112.7 nTPM (vital, limit 1); salivary gland: 101.2 nTPM (protected, limit 3); adipose tissue: 98.8 nTPM (manageable, limit 5); skin: 98.6 nTPM (manageable, limit 5); urinary bladder: 96.2 nTPM (protected, limit 3); colon: 95.8 nTPM (protected, limit 3); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 3); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); lymph node: 57.3 nTPM (protected, limit 3); parathyroid gland: 47.2 nTPM (protected, limit 3); thymus: 42.9 nTPM (manageable, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 3); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185236,RAB11B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 80%, Supported); adrenal gland: 75.0000% (minimum 97%, Supported); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 60.0000% (minimum 99%, Missing); bone marrow: 5.7692% (minimum 99%, Missing); cerebellum: 50.0000% (minimum 97%, Supported); cerebral cortex: 37.5000% (minimum 97%, Supported); colon: 42.8571% (minimum 90%, Supported); duodenum: 20.0000% (minimum 97%, Supported); esophagus: 50.0000% (minimum 90%, Supported); heart muscle: 37.5000% (minimum 97%, Supported); hippocampal formation: 75.0000% (minimum 99%, Missing); kidney: 42.8571% (minimum 97%, Supported); liver: 42.8571% (minimum 97%, Supported); lung: 20.0000% (minimum 97%, Supported); lymph node: 2.0548% (minimum 90%, Supported); pancreas: 75.0000% (minimum 97%, Supported); rectum: 42.8571% (minimum 90%, Supported); retina: 11.5385% (minimum 99%, Missing); salivary gland: 25.0000% (minimum 90%, Supported); skeletal muscle: 10.3448% (minimum 97%, Supported); skin: 11.5385% (minimum 80%, Supported); small intestine: 20.0000% (minimum 97%, Supported); spleen: 7.6923% (minimum 95%, Missing); stomach: 30.0000% (minimum 90%, Supported); thymus: 33.3333% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 80%, Supported); urinary bladder: 75.0000% (minimum 90%, Supported)",-0.873077,-0.879452,-0.932308,0,0,routine_complete,4.9,14.3,3.6,"lymph node: 14.3 nTPM (protected, limit 6); bone marrow: 4.9 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185245,GP1BA,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 55%, Supported); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); bone marrow: 5.7692% (minimum 75%, Missing); cerebellum: 50.0000% (minimum 65%, Supported); cerebral cortex: 37.5000% (minimum 65%, Supported); colon: 42.8571% (minimum 60%, Supported); duodenum: 20.0000% (minimum 65%, Supported); esophagus: 50.0000% (minimum 60%, Supported); heart muscle: 37.5000% (minimum 65%, Supported); hippocampal formation: 75.0000% (minimum 75%, Missing); kidney: 42.8571% (minimum 65%, Supported); liver: 42.8571% (minimum 65%, Supported); lung: 20.0000% (minimum 65%, Supported); lymph node: 2.0548% (minimum 60%, Supported); rectum: 42.8571% (minimum 60%, Supported); retina: 11.5385% (minimum 75%, Missing); salivary gland: 25.0000% (minimum 60%, Supported); skeletal muscle: 10.3448% (minimum 65%, Supported); skin: 11.5385% (minimum 55%, Supported); small intestine: 20.0000% (minimum 65%, Supported); spleen: 7.6923% (minimum 65%, Missing); stomach: 30.0000% (minimum 60%, Supported); thymus: 33.3333% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 55%, Supported)",-0.573077,-0.579452,-0.692308,0,0,routine_complete,4.9,14.3,3.6,"lymph node: 14.3 nTPM (protected, limit 6); bone marrow: 4.9 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185245,GP1BA,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 55%, Supported); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); bone marrow: 5.7692% (minimum 75%, Missing); cerebellum: 50.0000% (minimum 65%, Supported); cerebral cortex: 37.5000% (minimum 65%, Supported); colon: 42.8571% (minimum 60%, Supported); duodenum: 20.0000% (minimum 65%, Supported); esophagus: 50.0000% (minimum 60%, Supported); heart muscle: 37.5000% (minimum 65%, Supported); hippocampal formation: 75.0000% (minimum 75%, Missing); kidney: 42.8571% (minimum 65%, Supported); liver: 42.8571% (minimum 65%, Supported); lung: 20.0000% (minimum 65%, Supported); lymph node: 2.0548% (minimum 60%, Supported); rectum: 42.8571% (minimum 60%, Supported); retina: 11.5385% (minimum 75%, Missing); salivary gland: 25.0000% (minimum 60%, Supported); skeletal muscle: 10.3448% (minimum 65%, Supported); skin: 11.5385% (minimum 55%, Supported); small intestine: 20.0000% (minimum 65%, Supported); spleen: 7.6923% (minimum 65%, Missing); stomach: 30.0000% (minimum 60%, Supported); thymus: 33.3333% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 55%, Supported)",-0.573077,-0.579452,-0.692308,0,0,routine_complete,4.9,14.3,3.6,"lymph node: 14.3 nTPM (protected, limit 6); bone marrow: 4.9 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185245,GP1BA,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 55%, Supported); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); bone marrow: 5.7692% (minimum 75%, Missing); cerebellum: 50.0000% (minimum 65%, Supported); cerebral cortex: 37.5000% (minimum 65%, Supported); colon: 42.8571% (minimum 60%, Supported); duodenum: 20.0000% (minimum 65%, Supported); esophagus: 50.0000% (minimum 60%, Supported); heart muscle: 37.5000% (minimum 65%, Supported); hippocampal formation: 75.0000% (minimum 75%, Missing); kidney: 42.8571% (minimum 65%, Supported); liver: 42.8571% (minimum 65%, Supported); lung: 20.0000% (minimum 65%, Supported); lymph node: 2.0548% (minimum 60%, Supported); rectum: 42.8571% (minimum 60%, Supported); retina: 11.5385% (minimum 75%, Missing); salivary gland: 25.0000% (minimum 60%, Supported); skeletal muscle: 10.3448% (minimum 65%, Supported); skin: 11.5385% (minimum 55%, Supported); small intestine: 20.0000% (minimum 65%, Supported); spleen: 7.6923% (minimum 65%, Missing); stomach: 30.0000% (minimum 60%, Supported); thymus: 33.3333% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 55%, Supported)",-0.573077,-0.579452,-0.692308,0,0,routine_complete,4.9,14.3,3.6,"lymph node: 14.3 nTPM (protected, limit 6); bone marrow: 4.9 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185245,GP1BA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 75.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 5.7692% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 50.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 37.5000% (minimum 75%, Baseline (adaptation disabled)); colon: 42.8571% (minimum 70%, Baseline (adaptation disabled)); duodenum: 20.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 50.0000% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 37.5000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 42.8571% (minimum 75%, Baseline (adaptation disabled)); liver: 42.8571% (minimum 75%, Baseline (adaptation disabled)); lung: 20.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 2.0548% (minimum 70%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 75%, Baseline (adaptation disabled)); rectum: 42.8571% (minimum 70%, Baseline (adaptation disabled)); retina: 11.5385% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 25.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 10.3448% (minimum 75%, Baseline (adaptation disabled)); skin: 11.5385% (minimum 65%, Baseline (adaptation disabled)); small intestine: 20.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 7.6923% (minimum 65%, Baseline (adaptation disabled)); stomach: 30.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 33.3333% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 65%, Baseline (adaptation disabled))",-0.573077,-0.679452,-0.692308,0,0,routine_complete,4.9,14.3,3.6,"lymph node: 14.3 nTPM (protected, limit 3); bone marrow: 4.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185245,GP1BA,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.0251456,0.00514563,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,True,Research-screen eligibility does not establish clinical safety. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/normal-tissue-scopes/,ENSG00000185247,MAGEA11,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.295146,0.245146,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,True,Research-screen eligibility does not establish clinical safety. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/normal-tissue-scopes/,ENSG00000185247,MAGEA11,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.295146,0.245146,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,True,Research-screen eligibility does not establish clinical safety. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/normal-tissue-scopes/,ENSG00000185247,MAGEA11,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.295146,0.245146,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,True,Apply the same policy transition to the historical trace-RNA holdback. The current numerical gates assess the 0.1 nTPM choroid-plexus signal; no gene-specific ceiling or positive-IHC exemption.,True,Research-screen eligibility does not establish clinical safety. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/normal-tissue-scopes/,ENSG00000185247,MAGEA11,current_adaptive,True,True,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.295146,0.245146,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,True,Apply the same policy transition to the historical trace-RNA holdback. The current numerical gates assess the 0.1 nTPM choroid-plexus signal; no gene-specific ceiling or positive-IHC exemption.,True,Research-screen eligibility does not establish clinical safety. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/normal-tissue-scopes/,ENSG00000185247,MAGEA11,current_fixed,True,True,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Uncertain); adrenal gland: 72.9730% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 61.3636% (minimum 99%, Missing); bone marrow: 71.0526% (minimum 99%, Uncertain); cerebellum: 62.7907% (minimum 99%, Missing); cerebral cortex: 62.7907% (minimum 99%, Missing); choroid plexus: 81.8182% (minimum 99%, Missing); colon: 81.8182% (minimum 97%, Missing); duodenum: 84.3750% (minimum 99%, Missing); esophagus: 72.9730% (minimum 97%, Missing); heart muscle: 77.1429% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 67.5000% (minimum 99%, Missing); liver: 72.9730% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 77.1429% (minimum 97%, Missing); midbrain: 90.0000% (minimum 99%, Missing); pancreas: 77.1429% (minimum 99%, Missing); parathyroid gland: 67.5000% (minimum 97%, Missing); pituitary gland: 72.9730% (minimum 99%, Missing); rectum: 81.8182% (minimum 97%, Missing); retina: 45.7627% (minimum 99%, Missing); salivary gland: 79.4118% (minimum 97%, Missing); skeletal muscle: 65.8537% (minimum 99%, Missing); skin: 77.1429% (minimum 95%, Missing); small intestine: 84.3750% (minimum 99%, Missing); smooth muscle: 77.1429% (minimum 99%, Missing); spinal cord: 90.0000% (minimum 99%, Missing); spleen: 77.1429% (minimum 95%, Uncertain); stomach: 81.8182% (minimum 97%, Missing); thymus: 75.0000% (minimum 95%, Missing); thyroid gland: 61.3636% (minimum 95%, Missing); tongue: 72.9730% (minimum 97%, Missing); urinary bladder: 71.0526% (minimum 97%, Uncertain)",-0.336364,-0.295,-0.532373,0,3,partial,3.2,1.3,1.7,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185261,KIAA0825,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.9730% (minimum 75%, Missing); basal ganglia: 61.3636% (minimum 75%, Missing); bone marrow: 71.0526% (minimum 75%, Uncertain); cerebellum: 62.7907% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); kidney: 67.5000% (minimum 75%, Missing); liver: 72.9730% (minimum 75%, Missing); parathyroid gland: 67.5000% (minimum 70%, Missing); pituitary gland: 72.9730% (minimum 75%, Missing); retina: 45.7627% (minimum 75%, Missing); skeletal muscle: 65.8537% (minimum 75%, Missing); thyroid gland: 61.3636% (minimum 65%, Missing)",-0.0363636,-0.025,-0.292373,0,3,partial,3.2,1.3,1.7,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185261,KIAA0825,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.9730% (minimum 75%, Missing); basal ganglia: 61.3636% (minimum 75%, Missing); bone marrow: 71.0526% (minimum 75%, Uncertain); cerebellum: 62.7907% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); kidney: 67.5000% (minimum 75%, Missing); liver: 72.9730% (minimum 75%, Missing); parathyroid gland: 67.5000% (minimum 70%, Missing); pituitary gland: 72.9730% (minimum 75%, Missing); retina: 45.7627% (minimum 75%, Missing); skeletal muscle: 65.8537% (minimum 75%, Missing); thyroid gland: 61.3636% (minimum 65%, Missing)",-0.0363636,-0.025,-0.292373,0,3,partial,3.2,1.3,1.7,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185261,KIAA0825,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.9730% (minimum 75%, Missing); basal ganglia: 61.3636% (minimum 75%, Missing); bone marrow: 71.0526% (minimum 75%, Uncertain); cerebellum: 62.7907% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); kidney: 67.5000% (minimum 75%, Missing); liver: 72.9730% (minimum 75%, Missing); parathyroid gland: 67.5000% (minimum 70%, Missing); pituitary gland: 72.9730% (minimum 75%, Missing); retina: 45.7627% (minimum 75%, Missing); skeletal muscle: 65.8537% (minimum 75%, Missing); thyroid gland: 61.3636% (minimum 65%, Missing)",-0.0363636,-0.025,-0.292373,0,3,partial,3.2,1.3,1.7,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185261,KIAA0825,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.9730% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.3636% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 71.0526% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.7907% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.7907% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.5000% (minimum 75%, Baseline (adaptation disabled)); liver: 72.9730% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 67.5000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.9730% (minimum 75%, Baseline (adaptation disabled)); retina: 45.7627% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 65.8537% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 61.3636% (minimum 65%, Baseline (adaptation disabled))",-0.0363636,-0.025,-0.292373,0,3,partial,3.2,1.3,1.7,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185261,KIAA0825,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185264,CIMIP4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185264,CIMIP4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185264,CIMIP4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185264,CIMIP4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248876,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185264,CIMIP4,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 93.1059% (minimum 99%, Missing); lung: 98.4222% (minimum 99%, Missing); skeletal muscle: 94.3125% (minimum 99%, Missing)",0.0342224,0.0149624,-0.058941,0,80,unavailable,9.7,2,2.1,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185269,NOTUM,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334222,0.284962,0.181059,0,80,unavailable,9.7,2,2.1,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185269,NOTUM,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334222,0.284962,0.181059,0,80,unavailable,9.7,2,2.1,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185269,NOTUM,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334222,0.284962,0.181059,0,80,unavailable,9.7,2,2.1,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185269,NOTUM,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334222,0.284962,0.181059,0,80,unavailable,9.7,2,2.1,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185269,NOTUM,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.7748% (minimum 95%, Missing); adrenal gland: 83.8384% (minimum 99%, Missing); amygdala: 83.8384% (minimum 99%, Missing); basal ganglia: 83.0000% (minimum 99%, Missing); bone marrow: 61.4815% (minimum 99%, Missing); cerebellum: 83.0000% (minimum 99%, Missing); cerebral cortex: 80.5825% (minimum 99%, Missing); choroid plexus: 92.2222% (minimum 99%, Missing); colon: 82.1782% (minimum 97%, Missing); duodenum: 85.5670% (minimum 99%, Missing); esophagus: 86.4583% (minimum 97%, Missing); heart muscle: 80.5825% (minimum 99%, Missing); hippocampal formation: 81.3725% (minimum 99%, Missing); hypothalamus: 85.5670% (minimum 99%, Missing); kidney: 81.3725% (minimum 99%, Missing); liver: 82.1782% (minimum 99%, Missing); lung: 76.1468% (minimum 99%, Missing); lymph node: 70.9402% (minimum 97%, Missing); midbrain: 79.8077% (minimum 99%, Missing); pancreas: 83.0000% (minimum 99%, Missing); parathyroid gland: 83.0000% (minimum 97%, Missing); pituitary gland: 76.8519% (minimum 99%, Missing); rectum: 84.6939% (minimum 97%, Missing); retina: 44.8649% (minimum 99%, Missing); salivary gland: 81.3725% (minimum 97%, Missing); skeletal muscle: 83.0000% (minimum 99%, Missing); skin: 73.4513% (minimum 95%, Missing); small intestine: 79.0476% (minimum 99%, Missing); smooth muscle: 83.8384% (minimum 99%, Missing); spinal cord: 75.4545% (minimum 99%, Missing); spleen: 70.3390% (minimum 95%, Missing); stomach: 82.1782% (minimum 97%, Missing); thymus: 73.4513% (minimum 95%, Missing); thyroid gland: 76.8519% (minimum 95%, Missing); tongue: 79.8077% (minimum 97%, Missing); urinary bladder: 81.3725% (minimum 97%, Missing)",-0.24661,-0.260598,-0.541351,0,1,partial,10.2,3.4,3.5,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185278,ZBTB37,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4815% (minimum 75%, Missing); retina: 44.8649% (minimum 75%, Missing)",0.0533898,0.00940171,-0.301351,0,1,partial,10.2,3.4,3.5,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185278,ZBTB37,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4815% (minimum 75%, Missing); retina: 44.8649% (minimum 75%, Missing)",0.0533898,0.00940171,-0.301351,0,1,partial,10.2,3.4,3.5,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185278,ZBTB37,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4815% (minimum 75%, Missing); retina: 44.8649% (minimum 75%, Missing)",0.0533898,0.00940171,-0.301351,0,1,partial,10.2,3.4,3.5,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185278,ZBTB37,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4815% (minimum 75%, Baseline (adaptation disabled)); retina: 44.8649% (minimum 75%, Baseline (adaptation disabled))",0.0533898,0.00940171,-0.301351,0,1,partial,10.2,3.4,3.5,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185278,ZBTB37,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.0114% (minimum 99%, Missing); basal ganglia: 98.2067% (minimum 99%, Missing); cerebellum: 98.2346% (minimum 99%, Missing); cerebral cortex: 98.5714% (minimum 99%, Missing); hypothalamus: 98.5996% (minimum 99%, Missing); kidney: 95.1199% (minimum 99%, Missing); pancreas: 98.9106% (minimum 99%, Missing); pituitary gland: 96.5305% (minimum 99%, Missing)",0.00833333,0.0087234,-0.0388007,0,80,unavailable,17.7,7.5,15,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 2); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185290,NUPR2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.278723,0.201199,0,80,unavailable,17.7,7.5,15,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 2); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185290,NUPR2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.278723,0.201199,0,80,unavailable,17.7,7.5,15,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 3); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 3); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185290,NUPR2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.278723,0.201199,0,80,unavailable,17.7,7.5,15,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 3); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 3); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185290,NUPR2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.278723,0.201199,0,80,unavailable,17.7,7.5,15,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 3); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 3); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185290,NUPR2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 95.4667% (minimum 97%, Supported); pituitary gland: 98.8950% (minimum 99%, Missing)",0.05,0.03,-0.0153333,0,5,partial,1.7,0,0,,,49,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185294,SPPL2C,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.23895,0,5,partial,1.7,0,0,,,49,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185294,SPPL2C,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.23895,0,5,partial,1.7,0,0,,,49,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185294,SPPL2C,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.23895,0,5,partial,1.7,0,0,,,49,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185294,SPPL2C,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.204667,0,5,partial,1.7,0,0,"cerebellum: 1.7 nTPM (vital, limit 1)",,49,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185294,SPPL2C,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.6486% (minimum 99%, Missing); basal ganglia: 98.6486% (minimum 99%, Missing); choroid plexus: 75.2577% (minimum 99%, Missing); hippocampal formation: 98.6486% (minimum 99%, Missing); hypothalamus: 98.6486% (minimum 99%, Missing); midbrain: 98.6486% (minimum 99%, Missing); pituitary gland: 98.6486% (minimum 99%, Missing); retina: 83.9080% (minimum 99%, Missing); spinal cord: 97.3333% (minimum 99%, Missing); thymus: 80.2198% (minimum 95%, Missing)",-0.147802,0.03,-0.237423,0,2,partial,2.4,0.9,1.8,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185306,C12orf56,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.152198,0.3,0.00257732,0,2,partial,2.4,0.9,1.8,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185306,C12orf56,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.152198,0.3,0.00257732,0,2,partial,2.4,0.9,1.8,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185306,C12orf56,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.152198,0.3,0.00257732,0,2,partial,2.4,0.9,1.8,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185306,C12orf56,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.152198,0.190244,0.00257732,0,2,partial,2.4,0.9,1.8,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185306,C12orf56,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 50.0000% (minimum 99%, Missing)",0.05,0.03,-0.49,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185313,SCN10A,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185313,SCN10A,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185313,SCN10A,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185313,SCN10A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 50.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185313,SCN10A,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6061% (minimum 95%, Missing); adrenal gland: 32.7869% (minimum 99%, Missing); amygdala: 27.7778% (minimum 99%, Missing); basal ganglia: 25.3165% (minimum 99%, Missing); cerebellum: 57.1429% (minimum 99%, Missing); cerebral cortex: 10.6952% (minimum 99%, Missing); choroid plexus: 76.9231% (minimum 99%, Missing); colon: 90.9091% (minimum 97%, Missing); duodenum: 86.9565% (minimum 99%, Missing); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 68.9655% (minimum 99%, Missing); hippocampal formation: 15.5039% (minimum 99%, Missing); hypothalamus: 22.9885% (minimum 99%, Missing); kidney: 71.4286% (minimum 99%, Missing); midbrain: 40.0000% (minimum 99%, Missing); pancreas: 48.7805% (minimum 99%, Missing); parathyroid gland: 50.0000% (minimum 97%, Missing); pituitary gland: 51.2821% (minimum 99%, Missing); rectum: 95.2381% (minimum 97%, Missing); retina: 47.6190% (minimum 99%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 86.9565% (minimum 99%, Missing); smooth muscle: 57.1429% (minimum 99%, Missing); spinal cord: 57.1429% (minimum 99%, Missing); stomach: 71.4286% (minimum 97%, Missing); thyroid gland: 46.5116% (minimum 95%, Missing); urinary bladder: 43.4783% (minimum 97%, Missing)",-0.484884,-0.535217,-0.883048,0,80,unavailable,16.7,2.6,2.3,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185352,HS6ST3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6061% (minimum 65%, Missing); adrenal gland: 32.7869% (minimum 75%, Missing); amygdala: 27.7778% (minimum 75%, Missing); basal ganglia: 25.3165% (minimum 75%, Missing); cerebellum: 57.1429% (minimum 75%, Missing); cerebral cortex: 10.6952% (minimum 75%, Missing); heart muscle: 68.9655% (minimum 75%, Missing); hippocampal formation: 15.5039% (minimum 75%, Missing); hypothalamus: 22.9885% (minimum 75%, Missing); kidney: 71.4286% (minimum 75%, Missing); midbrain: 40.0000% (minimum 75%, Missing); pancreas: 48.7805% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 51.2821% (minimum 75%, Missing); retina: 47.6190% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); smooth muscle: 57.1429% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing); thyroid gland: 46.5116% (minimum 65%, Missing); urinary bladder: 43.4783% (minimum 70%, Missing)",-0.184884,-0.265217,-0.643048,0,80,unavailable,16.7,2.6,2.3,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185352,HS6ST3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6061% (minimum 65%, Missing); adrenal gland: 32.7869% (minimum 75%, Missing); amygdala: 27.7778% (minimum 75%, Missing); basal ganglia: 25.3165% (minimum 75%, Missing); cerebellum: 57.1429% (minimum 75%, Missing); cerebral cortex: 10.6952% (minimum 75%, Missing); heart muscle: 68.9655% (minimum 75%, Missing); hippocampal formation: 15.5039% (minimum 75%, Missing); hypothalamus: 22.9885% (minimum 75%, Missing); kidney: 71.4286% (minimum 75%, Missing); midbrain: 40.0000% (minimum 75%, Missing); pancreas: 48.7805% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 51.2821% (minimum 75%, Missing); retina: 47.6190% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); smooth muscle: 57.1429% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing); thyroid gland: 46.5116% (minimum 65%, Missing); urinary bladder: 43.4783% (minimum 70%, Missing)",-0.184884,-0.265217,-0.643048,0,80,unavailable,16.7,2.6,2.3,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185352,HS6ST3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6061% (minimum 65%, Missing); adrenal gland: 32.7869% (minimum 75%, Missing); amygdala: 27.7778% (minimum 75%, Missing); basal ganglia: 25.3165% (minimum 75%, Missing); cerebellum: 57.1429% (minimum 75%, Missing); cerebral cortex: 10.6952% (minimum 75%, Missing); heart muscle: 68.9655% (minimum 75%, Missing); hippocampal formation: 15.5039% (minimum 75%, Missing); hypothalamus: 22.9885% (minimum 75%, Missing); kidney: 71.4286% (minimum 75%, Missing); midbrain: 40.0000% (minimum 75%, Missing); pancreas: 48.7805% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 51.2821% (minimum 75%, Missing); retina: 47.6190% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); smooth muscle: 57.1429% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing); thyroid gland: 46.5116% (minimum 65%, Missing); urinary bladder: 43.4783% (minimum 70%, Missing)",-0.184884,-0.265217,-0.643048,0,80,unavailable,16.7,2.6,2.3,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185352,HS6ST3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6061% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 32.7869% (minimum 75%, Baseline (adaptation disabled)); amygdala: 27.7778% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 25.3165% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.1429% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 10.6952% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 68.9655% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 15.5039% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 22.9885% (minimum 75%, Baseline (adaptation disabled)); kidney: 71.4286% (minimum 75%, Baseline (adaptation disabled)); midbrain: 40.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 48.7805% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.0000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 51.2821% (minimum 75%, Baseline (adaptation disabled)); retina: 47.6190% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.1429% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.1429% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 46.5116% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 43.4783% (minimum 70%, Baseline (adaptation disabled))",-0.184884,-0.265217,-0.643048,0,80,unavailable,16.7,2.6,2.3,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185352,HS6ST3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.5155% (minimum 90%, Approved); adrenal gland: 44.7489% (minimum 98%, Approved); amygdala: 47.5728% (minimum 99%, Missing); basal ganglia: 51.3089% (minimum 99%, Missing); bone marrow: 74.8092% (minimum 99%, Missing); cerebellum: 49.7462% (minimum 99%, Missing); cerebral cortex: 44.3439% (minimum 99%, Missing); choroid plexus: 74.2424% (minimum 99%, Missing); colon: 50.7772% (minimum 95%, Approved); duodenum: 59.0361% (minimum 99%, Missing); esophagus: 40.8333% (minimum 97%, Missing); heart muscle: 37.6923% (minimum 98%, Approved); hippocampal formation: 50.5155% (minimum 99%, Missing); hypothalamus: 46.4455% (minimum 99%, Missing); kidney: 44.7489% (minimum 99%, Missing); liver: 42.4242% (minimum 99%, Missing); lung: 62.8205% (minimum 99%, Missing); lymph node: 65.7718% (minimum 97%, Missing); midbrain: 48.2759% (minimum 99%, Missing); pancreas: 47.3430% (minimum 99%, Missing); parathyroid gland: 57.9882% (minimum 97%, Missing); pituitary gland: 58.3333% (minimum 99%, Missing); rectum: 60.1227% (minimum 97%, Missing); retina: 62.8205% (minimum 99%, Missing); salivary gland: 50.5155% (minimum 97%, Missing); skeletal muscle: 25.5875% (minimum 98%, Approved); skin: 48.7562% (minimum 95%, Missing); small intestine: 55.6818% (minimum 99%, Missing); smooth muscle: 65.7718% (minimum 98%, Approved); spinal cord: 44.7489% (minimum 99%, Missing); spleen: 58.6826% (minimum 95%, Missing); stomach: 50.0000% (minimum 97%, Missing); thymus: 57.6471% (minimum 95%, Missing); thyroid gland: 59.0361% (minimum 95%, Missing); tongue: 32.6667% (minimum 97%, Missing); urinary bladder: 52.1277% (minimum 97%, Missing)",-0.462438,-0.643333,-0.724125,0,7,partial,28.5,20.2,10.3,"skeletal muscle: 28.5 nTPM (vital, limit 2); tongue: 20.2 nTPM (protected, limit 2); heart muscle: 16.2 nTPM (vital, limit 2); esophagus: 14.2 nTPM (protected, limit 2); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 2); spinal cord: 12.1 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 2); salivary gland: 9.6 nTPM (protected, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 4); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); small intestine: 7.8 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.1 nTPM (protected, limit 2); pituitary gland: 7 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 2); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); smooth muscle: 5.1 nTPM (vital, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185414,MRPL30,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.5155% (minimum 60%, Approved); adrenal gland: 44.7489% (minimum 70%, Approved); amygdala: 47.5728% (minimum 75%, Missing); basal ganglia: 51.3089% (minimum 75%, Missing); bone marrow: 74.8092% (minimum 75%, Missing); cerebellum: 49.7462% (minimum 75%, Missing); cerebral cortex: 44.3439% (minimum 75%, Missing); choroid plexus: 74.2424% (minimum 75%, Missing); colon: 50.7772% (minimum 65%, Approved); duodenum: 59.0361% (minimum 75%, Missing); esophagus: 40.8333% (minimum 70%, Missing); heart muscle: 37.6923% (minimum 70%, Approved); hippocampal formation: 50.5155% (minimum 75%, Missing); hypothalamus: 46.4455% (minimum 75%, Missing); kidney: 44.7489% (minimum 75%, Missing); liver: 42.4242% (minimum 75%, Missing); lung: 62.8205% (minimum 75%, Missing); lymph node: 65.7718% (minimum 70%, Missing); midbrain: 48.2759% (minimum 75%, Missing); pancreas: 47.3430% (minimum 75%, Missing); parathyroid gland: 57.9882% (minimum 70%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); rectum: 60.1227% (minimum 70%, Missing); retina: 62.8205% (minimum 75%, Missing); salivary gland: 50.5155% (minimum 70%, Missing); skeletal muscle: 25.5875% (minimum 70%, Approved); skin: 48.7562% (minimum 65%, Missing); small intestine: 55.6818% (minimum 75%, Missing); smooth muscle: 65.7718% (minimum 70%, Approved); spinal cord: 44.7489% (minimum 75%, Missing); spleen: 58.6826% (minimum 65%, Missing); stomach: 50.0000% (minimum 70%, Missing); thymus: 57.6471% (minimum 65%, Missing); thyroid gland: 59.0361% (minimum 65%, Missing); tongue: 32.6667% (minimum 70%, Missing); urinary bladder: 52.1277% (minimum 70%, Missing)",-0.162438,-0.373333,-0.444125,0,7,partial,28.5,20.2,10.3,"skeletal muscle: 28.5 nTPM (vital, limit 2); tongue: 20.2 nTPM (protected, limit 2); heart muscle: 16.2 nTPM (vital, limit 2); esophagus: 14.2 nTPM (protected, limit 2); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 2); spinal cord: 12.1 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 2); salivary gland: 9.6 nTPM (protected, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 4); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); small intestine: 7.8 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.1 nTPM (protected, limit 2); pituitary gland: 7 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 2); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); smooth muscle: 5.1 nTPM (vital, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185414,MRPL30,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.5155% (minimum 60%, Approved); adrenal gland: 44.7489% (minimum 70%, Approved); amygdala: 47.5728% (minimum 75%, Missing); basal ganglia: 51.3089% (minimum 75%, Missing); bone marrow: 74.8092% (minimum 75%, Missing); cerebellum: 49.7462% (minimum 75%, Missing); cerebral cortex: 44.3439% (minimum 75%, Missing); choroid plexus: 74.2424% (minimum 75%, Missing); colon: 50.7772% (minimum 65%, Approved); duodenum: 59.0361% (minimum 75%, Missing); esophagus: 40.8333% (minimum 70%, Missing); heart muscle: 37.6923% (minimum 70%, Approved); hippocampal formation: 50.5155% (minimum 75%, Missing); hypothalamus: 46.4455% (minimum 75%, Missing); kidney: 44.7489% (minimum 75%, Missing); liver: 42.4242% (minimum 75%, Missing); lung: 62.8205% (minimum 75%, Missing); lymph node: 65.7718% (minimum 70%, Missing); midbrain: 48.2759% (minimum 75%, Missing); pancreas: 47.3430% (minimum 75%, Missing); parathyroid gland: 57.9882% (minimum 70%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); rectum: 60.1227% (minimum 70%, Missing); retina: 62.8205% (minimum 75%, Missing); salivary gland: 50.5155% (minimum 70%, Missing); skeletal muscle: 25.5875% (minimum 70%, Approved); skin: 48.7562% (minimum 65%, Missing); small intestine: 55.6818% (minimum 75%, Missing); smooth muscle: 65.7718% (minimum 70%, Approved); spinal cord: 44.7489% (minimum 75%, Missing); spleen: 58.6826% (minimum 65%, Missing); stomach: 50.0000% (minimum 70%, Missing); thymus: 57.6471% (minimum 65%, Missing); thyroid gland: 59.0361% (minimum 65%, Missing); tongue: 32.6667% (minimum 70%, Missing); urinary bladder: 52.1277% (minimum 70%, Missing)",-0.162438,-0.373333,-0.444125,0,7,partial,28.5,20.2,10.3,"skeletal muscle: 28.5 nTPM (vital, limit 2); tongue: 20.2 nTPM (protected, limit 3); heart muscle: 16.2 nTPM (vital, limit 2); esophagus: 14.2 nTPM (protected, limit 3); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 2); spinal cord: 12.1 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 3); salivary gland: 9.6 nTPM (protected, limit 3); hippocampal formation: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 4); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); small intestine: 7.8 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.1 nTPM (protected, limit 3); pituitary gland: 7 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 3); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); smooth muscle: 5.1 nTPM (vital, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185414,MRPL30,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.5155% (minimum 60%, Approved); adrenal gland: 44.7489% (minimum 70%, Approved); amygdala: 47.5728% (minimum 75%, Missing); basal ganglia: 51.3089% (minimum 75%, Missing); bone marrow: 74.8092% (minimum 75%, Missing); cerebellum: 49.7462% (minimum 75%, Missing); cerebral cortex: 44.3439% (minimum 75%, Missing); choroid plexus: 74.2424% (minimum 75%, Missing); colon: 50.7772% (minimum 65%, Approved); duodenum: 59.0361% (minimum 75%, Missing); esophagus: 40.8333% (minimum 70%, Missing); heart muscle: 37.6923% (minimum 70%, Approved); hippocampal formation: 50.5155% (minimum 75%, Missing); hypothalamus: 46.4455% (minimum 75%, Missing); kidney: 44.7489% (minimum 75%, Missing); liver: 42.4242% (minimum 75%, Missing); lung: 62.8205% (minimum 75%, Missing); lymph node: 65.7718% (minimum 70%, Missing); midbrain: 48.2759% (minimum 75%, Missing); pancreas: 47.3430% (minimum 75%, Missing); parathyroid gland: 57.9882% (minimum 70%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); rectum: 60.1227% (minimum 70%, Missing); retina: 62.8205% (minimum 75%, Missing); salivary gland: 50.5155% (minimum 70%, Missing); skeletal muscle: 25.5875% (minimum 70%, Approved); skin: 48.7562% (minimum 65%, Missing); small intestine: 55.6818% (minimum 75%, Missing); smooth muscle: 65.7718% (minimum 70%, Approved); spinal cord: 44.7489% (minimum 75%, Missing); spleen: 58.6826% (minimum 65%, Missing); stomach: 50.0000% (minimum 70%, Missing); thymus: 57.6471% (minimum 65%, Missing); thyroid gland: 59.0361% (minimum 65%, Missing); tongue: 32.6667% (minimum 70%, Missing); urinary bladder: 52.1277% (minimum 70%, Missing)",-0.162438,-0.373333,-0.444125,0,7,partial,28.5,20.2,10.3,"skeletal muscle: 28.5 nTPM (vital, limit 2); tongue: 20.2 nTPM (protected, limit 3); heart muscle: 16.2 nTPM (vital, limit 2); esophagus: 14.2 nTPM (protected, limit 3); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 2); spinal cord: 12.1 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 3); salivary gland: 9.6 nTPM (protected, limit 3); hippocampal formation: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 4); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); small intestine: 7.8 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.1 nTPM (protected, limit 3); pituitary gland: 7 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 3); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); smooth muscle: 5.1 nTPM (vital, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185414,MRPL30,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.5155% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 44.7489% (minimum 75%, Baseline (adaptation disabled)); amygdala: 47.5728% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 51.3089% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 74.8092% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 49.7462% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 44.3439% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.2424% (minimum 75%, Baseline (adaptation disabled)); colon: 50.7772% (minimum 70%, Baseline (adaptation disabled)); duodenum: 59.0361% (minimum 75%, Baseline (adaptation disabled)); esophagus: 40.8333% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 37.6923% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.5155% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 46.4455% (minimum 75%, Baseline (adaptation disabled)); kidney: 44.7489% (minimum 75%, Baseline (adaptation disabled)); liver: 42.4242% (minimum 75%, Baseline (adaptation disabled)); lung: 62.8205% (minimum 75%, Baseline (adaptation disabled)); lymph node: 65.7718% (minimum 70%, Baseline (adaptation disabled)); midbrain: 48.2759% (minimum 75%, Baseline (adaptation disabled)); pancreas: 47.3430% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.9882% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.3333% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.1227% (minimum 70%, Baseline (adaptation disabled)); retina: 62.8205% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.5155% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 25.5875% (minimum 75%, Baseline (adaptation disabled)); skin: 48.7562% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.6818% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.7718% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 44.7489% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.6826% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.6471% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 59.0361% (minimum 65%, Baseline (adaptation disabled)); tongue: 32.6667% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.1277% (minimum 70%, Baseline (adaptation disabled))",-0.162438,-0.373333,-0.494125,0,7,partial,28.5,20.2,10.3,"skeletal muscle: 28.5 nTPM (vital, limit 1); tongue: 20.2 nTPM (protected, limit 3); heart muscle: 16.2 nTPM (vital, limit 1); esophagus: 14.2 nTPM (protected, limit 3); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); spinal cord: 12.1 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 3); salivary gland: 9.6 nTPM (protected, limit 3); adipose tissue: 9.6 nTPM (manageable, limit 5); hippocampal formation: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 3); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); small intestine: 7.8 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.1 nTPM (protected, limit 3); pituitary gland: 7 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 3); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); smooth muscle: 5.1 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185414,MRPL30,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185448,FAM47A,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185448,FAM47A,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185448,FAM47A,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185448,FAM47A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185448,FAM47A,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.6087% (minimum 90%, Approved); adrenal gland: 86.3636% (minimum 99%, Missing); amygdala: 92.6829% (minimum 99%, Missing); basal ganglia: 92.6829% (minimum 99%, Missing); bone marrow: 29.2308% (minimum 99%, Missing); cerebellum: 90.4762% (minimum 99%, Missing); cerebral cortex: 86.3636% (minimum 99%, Missing); colon: 56.7164% (minimum 97%, Missing); duodenum: 63.3333% (minimum 98%, Approved); esophagus: 52.0548% (minimum 97%, Missing); heart muscle: 92.6829% (minimum 99%, Missing); hippocampal formation: 92.6829% (minimum 99%, Missing); hypothalamus: 77.5510% (minimum 99%, Missing); kidney: 82.6087% (minimum 99%, Missing); liver: 86.3636% (minimum 98%, Approved); lung: 86.3636% (minimum 99%, Missing); lymph node: 48.1013% (minimum 95%, Approved); midbrain: 88.3721% (minimum 99%, Missing); pancreas: 92.6829% (minimum 99%, Missing); parathyroid gland: 92.6829% (minimum 97%, Missing); pituitary gland: 95.0000% (minimum 99%, Missing); rectum: 50.6667% (minimum 97%, Missing); retina: 95.0000% (minimum 99%, Missing); salivary gland: 80.8511% (minimum 97%, Missing); skeletal muscle: 92.6829% (minimum 99%, Missing); skin: 66.6667% (minimum 95%, Missing); small intestine: 58.4615% (minimum 99%, Missing); smooth muscle: 70.3704% (minimum 99%, Missing); spinal cord: 90.4762% (minimum 99%, Missing); spleen: 76.0000% (minimum 90%, Approved); stomach: 67.8571% (minimum 97%, Missing); thymus: 33.9286% (minimum 95%, Missing); thyroid gland: 88.3721% (minimum 95%, Missing); tongue: 90.4762% (minimum 97%, Missing); urinary bladder: 67.8571% (minimum 97%, Missing)",-0.610714,-0.468987,-0.697692,0,8,partial,9.2,4.1,7.4,"bone marrow: 9.2 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); lymph node: 4.1 nTPM (protected, limit 4); rectum: 3.7 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185480,PARPBP,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 29.2308% (minimum 75%, Missing); colon: 56.7164% (minimum 70%, Missing); duodenum: 63.3333% (minimum 70%, Approved); esophagus: 52.0548% (minimum 70%, Missing); lymph node: 48.1013% (minimum 65%, Approved); rectum: 50.6667% (minimum 70%, Missing); small intestine: 58.4615% (minimum 75%, Missing); smooth muscle: 70.3704% (minimum 75%, Missing); stomach: 67.8571% (minimum 70%, Missing); thymus: 33.9286% (minimum 65%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.310714,-0.193333,-0.457692,0,8,partial,9.2,4.1,7.4,"bone marrow: 9.2 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); lymph node: 4.1 nTPM (protected, limit 4); rectum: 3.7 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185480,PARPBP,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 29.2308% (minimum 75%, Missing); colon: 56.7164% (minimum 70%, Missing); duodenum: 63.3333% (minimum 70%, Approved); esophagus: 52.0548% (minimum 70%, Missing); lymph node: 48.1013% (minimum 65%, Approved); rectum: 50.6667% (minimum 70%, Missing); small intestine: 58.4615% (minimum 75%, Missing); smooth muscle: 70.3704% (minimum 75%, Missing); stomach: 67.8571% (minimum 70%, Missing); thymus: 33.9286% (minimum 65%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.310714,-0.193333,-0.457692,0,8,partial,9.2,4.1,7.4,"bone marrow: 9.2 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); lymph node: 4.1 nTPM (protected, limit 4); rectum: 3.7 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185480,PARPBP,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 29.2308% (minimum 75%, Missing); colon: 56.7164% (minimum 70%, Missing); duodenum: 63.3333% (minimum 70%, Approved); esophagus: 52.0548% (minimum 70%, Missing); lymph node: 48.1013% (minimum 65%, Approved); rectum: 50.6667% (minimum 70%, Missing); small intestine: 58.4615% (minimum 75%, Missing); smooth muscle: 70.3704% (minimum 75%, Missing); stomach: 67.8571% (minimum 70%, Missing); thymus: 33.9286% (minimum 65%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.310714,-0.193333,-0.457692,0,8,partial,9.2,4.1,7.4,"bone marrow: 9.2 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); lymph node: 4.1 nTPM (protected, limit 4); rectum: 3.7 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185480,PARPBP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 29.2308% (minimum 75%, Baseline (adaptation disabled)); colon: 56.7164% (minimum 70%, Baseline (adaptation disabled)); duodenum: 63.3333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.0548% (minimum 70%, Baseline (adaptation disabled)); lymph node: 48.1013% (minimum 70%, Baseline (adaptation disabled)); rectum: 50.6667% (minimum 70%, Baseline (adaptation disabled)); small intestine: 58.4615% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.3704% (minimum 75%, Baseline (adaptation disabled)); stomach: 67.8571% (minimum 70%, Baseline (adaptation disabled)); thymus: 33.9286% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 67.8571% (minimum 70%, Baseline (adaptation disabled))",-0.310714,-0.218987,-0.457692,0,8,partial,9.2,4.1,7.4,"bone marrow: 9.2 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); lymph node: 4.1 nTPM (protected, limit 3); rectum: 3.7 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185480,PARPBP,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2906% (minimum 99%, Missing); basal ganglia: 98.2906% (minimum 99%, Missing); bone marrow: 97.4576% (minimum 99%, Missing); cerebral cortex: 98.2906% (minimum 99%, Missing); hippocampal formation: 98.2906% (minimum 99%, Missing); hypothalamus: 98.2906% (minimum 99%, Missing); kidney: 97.4576% (minimum 99%, Missing); liver: 96.6387% (minimum 99%, Missing); lung: 96.6387% (minimum 99%, Missing); lymph node: 93.4959% (minimum 97%, Missing); midbrain: 98.2906% (minimum 99%, Missing); pancreas: 79.8611% (minimum 99%, Missing); pituitary gland: 97.4576% (minimum 99%, Missing); retina: 95.8333% (minimum 99%, Missing); smooth muscle: 95.8333% (minimum 99%, Missing); spinal cord: 97.4576% (minimum 99%, Missing); tongue: 95.8333% (minimum 97%, Missing)",0.00833333,-0.0350407,-0.191389,0,80,unavailable,2.9,0.8,0.5,"pancreas: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185523,SPATA45,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.234959,0.0486111,0,80,unavailable,2.9,0.8,0.5,"pancreas: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185523,SPATA45,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.234959,0.0486111,0,80,unavailable,2.9,0.8,0.5,"pancreas: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185523,SPATA45,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.234959,0.0486111,0,80,unavailable,2.9,0.8,0.5,"pancreas: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185523,SPATA45,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.234959,0.0486111,0,80,unavailable,2.9,0.8,0.5,"pancreas: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185523,SPATA45,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.8919% (minimum 99%, Missing); amygdala: 54.5455% (minimum 99%, Missing); basal ganglia: 50.0000% (minimum 99%, Missing); cerebellum: 85.0000% (minimum 99%, Missing); cerebral cortex: 57.6271% (minimum 99%, Missing); choroid plexus: 89.4737% (minimum 99%, Missing); colon: 79.0698% (minimum 97%, Missing); duodenum: 97.1429% (minimum 99%, Missing); esophagus: 95.3271% (minimum 97%, Missing); heart muscle: 76.1194% (minimum 99%, Missing); hippocampal formation: 48.5714% (minimum 99%, Missing); hypothalamus: 62.5767% (minimum 99%, Missing); kidney: 97.1429% (minimum 99%, Missing); lung: 97.1429% (minimum 99%, Missing); midbrain: 44.9339% (minimum 99%, Missing); pancreas: 98.0769% (minimum 99%, Missing); pituitary gland: 91.0714% (minimum 99%, Missing); rectum: 95.3271% (minimum 97%, Missing); retina: 92.7273% (minimum 99%, Missing); salivary gland: 83.6066% (minimum 97%, Missing); skeletal muscle: 91.8919% (minimum 99%, Missing); skin: 94.4444% (minimum 95%, Missing); small intestine: 93.5780% (minimum 99%, Missing); smooth muscle: 93.5780% (minimum 99%, Missing); spinal cord: 39.8437% (minimum 99%, Missing); stomach: 94.4444% (minimum 97%, Missing); tongue: 90.2655% (minimum 97%, Missing); urinary bladder: 96.2264% (minimum 97%, Missing)",-0.00555556,-0.179302,-0.591562,0,80,unavailable,15.4,2.7,0.6,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185634,SHC4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 54.5455% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebral cortex: 57.6271% (minimum 75%, Missing); hippocampal formation: 48.5714% (minimum 75%, Missing); hypothalamus: 62.5767% (minimum 75%, Missing); midbrain: 44.9339% (minimum 75%, Missing); spinal cord: 39.8437% (minimum 75%, Missing)",0.294444,0.0906977,-0.351563,0,80,unavailable,15.4,2.7,0.6,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185634,SHC4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 54.5455% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebral cortex: 57.6271% (minimum 75%, Missing); hippocampal formation: 48.5714% (minimum 75%, Missing); hypothalamus: 62.5767% (minimum 75%, Missing); midbrain: 44.9339% (minimum 75%, Missing); spinal cord: 39.8437% (minimum 75%, Missing)",0.294444,0.0906977,-0.351563,0,80,unavailable,15.4,2.7,0.6,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185634,SHC4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 54.5455% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebral cortex: 57.6271% (minimum 75%, Missing); hippocampal formation: 48.5714% (minimum 75%, Missing); hypothalamus: 62.5767% (minimum 75%, Missing); midbrain: 44.9339% (minimum 75%, Missing); spinal cord: 39.8437% (minimum 75%, Missing)",0.294444,0.0906977,-0.351563,0,80,unavailable,15.4,2.7,0.6,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185634,SHC4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 54.5455% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 50.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.6271% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 48.5714% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.5767% (minimum 75%, Baseline (adaptation disabled)); midbrain: 44.9339% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 39.8437% (minimum 75%, Baseline (adaptation disabled))",0.294444,0.0906977,-0.351563,0,80,unavailable,15.4,2.7,0.6,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185634,SHC4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.7841% (minimum 95%, Missing); adrenal gland: 54.7030% (minimum 99%, Missing); amygdala: 35.4167% (minimum 99%, Missing); basal ganglia: 33.6890% (minimum 99%, Missing); bone marrow: 54.5679% (minimum 99%, Missing); cerebellum: 54.1667% (minimum 99%, Missing); cerebral cortex: 29.5060% (minimum 99%, Missing); choroid plexus: 62.4294% (minimum 99%, Missing); colon: 64.6199% (minimum 97%, Missing); duodenum: 69.9367% (minimum 99%, Missing); esophagus: 65.5786% (minimum 97%, Missing); heart muscle: 59.5687% (minimum 99%, Missing); hippocampal formation: 38.5017% (minimum 99%, Missing); hypothalamus: 35.4735% (minimum 99%, Missing); kidney: 59.2493% (minimum 99%, Missing); liver: 46.9214% (minimum 99%, Missing); lung: 63.3238% (minimum 99%, Missing); lymph node: 58.9333% (minimum 97%, Missing); midbrain: 42.5819% (minimum 99%, Missing); pancreas: 53.3816% (minimum 99%, Missing); parathyroid gland: 63.6888% (minimum 97%, Missing); pituitary gland: 63.1429% (minimum 99%, Missing); rectum: 65.0000% (minimum 97%, Missing); retina: 37.1429% (minimum 99%, Missing); salivary gland: 66.1677% (minimum 97%, Missing); skeletal muscle: 51.1574% (minimum 99%, Missing); skin: 60.8815% (minimum 95%, Missing); small intestine: 66.7674% (minimum 99%, Missing); smooth muscle: 67.3780% (minimum 99%, Missing); spinal cord: 51.0393% (minimum 99%, Missing); spleen: 67.3780% (minimum 95%, Missing); stomach: 65.1917% (minimum 97%, Missing); thymus: 60.3825% (minimum 95%, Missing); thyroid gland: 53.6408% (minimum 95%, Missing); tongue: 48.8938% (minimum 97%, Missing); urinary bladder: 64.8094% (minimum 97%, Missing)",-0.413592,-0.481062,-0.69494,0,1,partial,52.8,23.1,19.1,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 2); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 2); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); thymus: 14.5 nTPM (manageable, limit 5); skin: 14.2 nTPM (manageable, limit 5); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (manageable, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 2); colon: 12.1 nTPM (protected, limit 2); urinary bladder: 12 nTPM (protected, limit 2); rectum: 11.9 nTPM (protected, limit 2); stomach: 11.8 nTPM (protected, limit 2); esophagus: 11.6 nTPM (protected, limit 2); salivary gland: 11.3 nTPM (protected, limit 2); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185658,BRWD1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.7841% (minimum 65%, Missing); adrenal gland: 54.7030% (minimum 75%, Missing); amygdala: 35.4167% (minimum 75%, Missing); basal ganglia: 33.6890% (minimum 75%, Missing); bone marrow: 54.5679% (minimum 75%, Missing); cerebellum: 54.1667% (minimum 75%, Missing); cerebral cortex: 29.5060% (minimum 75%, Missing); choroid plexus: 62.4294% (minimum 75%, Missing); colon: 64.6199% (minimum 70%, Missing); duodenum: 69.9367% (minimum 75%, Missing); esophagus: 65.5786% (minimum 70%, Missing); heart muscle: 59.5687% (minimum 75%, Missing); hippocampal formation: 38.5017% (minimum 75%, Missing); hypothalamus: 35.4735% (minimum 75%, Missing); kidney: 59.2493% (minimum 75%, Missing); liver: 46.9214% (minimum 75%, Missing); lung: 63.3238% (minimum 75%, Missing); lymph node: 58.9333% (minimum 70%, Missing); midbrain: 42.5819% (minimum 75%, Missing); pancreas: 53.3816% (minimum 75%, Missing); parathyroid gland: 63.6888% (minimum 70%, Missing); pituitary gland: 63.1429% (minimum 75%, Missing); rectum: 65.0000% (minimum 70%, Missing); retina: 37.1429% (minimum 75%, Missing); salivary gland: 66.1677% (minimum 70%, Missing); skeletal muscle: 51.1574% (minimum 75%, Missing); skin: 60.8815% (minimum 65%, Missing); small intestine: 66.7674% (minimum 75%, Missing); smooth muscle: 67.3780% (minimum 75%, Missing); spinal cord: 51.0393% (minimum 75%, Missing); stomach: 65.1917% (minimum 70%, Missing); thymus: 60.3825% (minimum 65%, Missing); thyroid gland: 53.6408% (minimum 65%, Missing); tongue: 48.8938% (minimum 70%, Missing); urinary bladder: 64.8094% (minimum 70%, Missing)",-0.113592,-0.211062,-0.45494,0,1,partial,52.8,23.1,19.1,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 2); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 2); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); thymus: 14.5 nTPM (manageable, limit 5); skin: 14.2 nTPM (manageable, limit 5); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (manageable, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 2); colon: 12.1 nTPM (protected, limit 2); urinary bladder: 12 nTPM (protected, limit 2); rectum: 11.9 nTPM (protected, limit 2); stomach: 11.8 nTPM (protected, limit 2); esophagus: 11.6 nTPM (protected, limit 2); salivary gland: 11.3 nTPM (protected, limit 2); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185658,BRWD1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.7841% (minimum 65%, Missing); adrenal gland: 54.7030% (minimum 75%, Missing); amygdala: 35.4167% (minimum 75%, Missing); basal ganglia: 33.6890% (minimum 75%, Missing); bone marrow: 54.5679% (minimum 75%, Missing); cerebellum: 54.1667% (minimum 75%, Missing); cerebral cortex: 29.5060% (minimum 75%, Missing); choroid plexus: 62.4294% (minimum 75%, Missing); colon: 64.6199% (minimum 70%, Missing); duodenum: 69.9367% (minimum 75%, Missing); esophagus: 65.5786% (minimum 70%, Missing); heart muscle: 59.5687% (minimum 75%, Missing); hippocampal formation: 38.5017% (minimum 75%, Missing); hypothalamus: 35.4735% (minimum 75%, Missing); kidney: 59.2493% (minimum 75%, Missing); liver: 46.9214% (minimum 75%, Missing); lung: 63.3238% (minimum 75%, Missing); lymph node: 58.9333% (minimum 70%, Missing); midbrain: 42.5819% (minimum 75%, Missing); pancreas: 53.3816% (minimum 75%, Missing); parathyroid gland: 63.6888% (minimum 70%, Missing); pituitary gland: 63.1429% (minimum 75%, Missing); rectum: 65.0000% (minimum 70%, Missing); retina: 37.1429% (minimum 75%, Missing); salivary gland: 66.1677% (minimum 70%, Missing); skeletal muscle: 51.1574% (minimum 75%, Missing); skin: 60.8815% (minimum 65%, Missing); small intestine: 66.7674% (minimum 75%, Missing); smooth muscle: 67.3780% (minimum 75%, Missing); spinal cord: 51.0393% (minimum 75%, Missing); stomach: 65.1917% (minimum 70%, Missing); thymus: 60.3825% (minimum 65%, Missing); thyroid gland: 53.6408% (minimum 65%, Missing); tongue: 48.8938% (minimum 70%, Missing); urinary bladder: 64.8094% (minimum 70%, Missing)",-0.113592,-0.211062,-0.45494,0,1,partial,52.8,23.1,19.1,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 3); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 3); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); thymus: 14.5 nTPM (manageable, limit 5); skin: 14.2 nTPM (manageable, limit 5); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (manageable, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 3); colon: 12.1 nTPM (protected, limit 3); urinary bladder: 12 nTPM (protected, limit 3); rectum: 11.9 nTPM (protected, limit 3); stomach: 11.8 nTPM (protected, limit 3); esophagus: 11.6 nTPM (protected, limit 3); salivary gland: 11.3 nTPM (protected, limit 3); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185658,BRWD1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.7841% (minimum 65%, Missing); adrenal gland: 54.7030% (minimum 75%, Missing); amygdala: 35.4167% (minimum 75%, Missing); basal ganglia: 33.6890% (minimum 75%, Missing); bone marrow: 54.5679% (minimum 75%, Missing); cerebellum: 54.1667% (minimum 75%, Missing); cerebral cortex: 29.5060% (minimum 75%, Missing); choroid plexus: 62.4294% (minimum 75%, Missing); colon: 64.6199% (minimum 70%, Missing); duodenum: 69.9367% (minimum 75%, Missing); esophagus: 65.5786% (minimum 70%, Missing); heart muscle: 59.5687% (minimum 75%, Missing); hippocampal formation: 38.5017% (minimum 75%, Missing); hypothalamus: 35.4735% (minimum 75%, Missing); kidney: 59.2493% (minimum 75%, Missing); liver: 46.9214% (minimum 75%, Missing); lung: 63.3238% (minimum 75%, Missing); lymph node: 58.9333% (minimum 70%, Missing); midbrain: 42.5819% (minimum 75%, Missing); pancreas: 53.3816% (minimum 75%, Missing); parathyroid gland: 63.6888% (minimum 70%, Missing); pituitary gland: 63.1429% (minimum 75%, Missing); rectum: 65.0000% (minimum 70%, Missing); retina: 37.1429% (minimum 75%, Missing); salivary gland: 66.1677% (minimum 70%, Missing); skeletal muscle: 51.1574% (minimum 75%, Missing); skin: 60.8815% (minimum 65%, Missing); small intestine: 66.7674% (minimum 75%, Missing); smooth muscle: 67.3780% (minimum 75%, Missing); spinal cord: 51.0393% (minimum 75%, Missing); stomach: 65.1917% (minimum 70%, Missing); thymus: 60.3825% (minimum 65%, Missing); thyroid gland: 53.6408% (minimum 65%, Missing); tongue: 48.8938% (minimum 70%, Missing); urinary bladder: 64.8094% (minimum 70%, Missing)",-0.113592,-0.211062,-0.45494,0,1,partial,52.8,23.1,19.1,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 3); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 3); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); thymus: 14.5 nTPM (manageable, limit 5); skin: 14.2 nTPM (manageable, limit 5); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (manageable, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 3); colon: 12.1 nTPM (protected, limit 3); urinary bladder: 12 nTPM (protected, limit 3); rectum: 11.9 nTPM (protected, limit 3); stomach: 11.8 nTPM (protected, limit 3); esophagus: 11.6 nTPM (protected, limit 3); salivary gland: 11.3 nTPM (protected, limit 3); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185658,BRWD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.7841% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 54.7030% (minimum 75%, Baseline (adaptation disabled)); amygdala: 35.4167% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 33.6890% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 54.5679% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.1667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 29.5060% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 62.4294% (minimum 75%, Baseline (adaptation disabled)); colon: 64.6199% (minimum 70%, Baseline (adaptation disabled)); duodenum: 69.9367% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.5786% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.5687% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 38.5017% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 35.4735% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.2493% (minimum 75%, Baseline (adaptation disabled)); liver: 46.9214% (minimum 75%, Baseline (adaptation disabled)); lung: 63.3238% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.9333% (minimum 70%, Baseline (adaptation disabled)); midbrain: 42.5819% (minimum 75%, Baseline (adaptation disabled)); pancreas: 53.3816% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.6888% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.1429% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 37.1429% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.1677% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 51.1574% (minimum 75%, Baseline (adaptation disabled)); skin: 60.8815% (minimum 65%, Baseline (adaptation disabled)); small intestine: 66.7674% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.3780% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 51.0393% (minimum 75%, Baseline (adaptation disabled)); stomach: 65.1917% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.3825% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.6408% (minimum 65%, Baseline (adaptation disabled)); tongue: 48.8938% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 64.8094% (minimum 70%, Baseline (adaptation disabled))",-0.113592,-0.211062,-0.45494,0,1,partial,52.8,23.1,19.1,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 3); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 3); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); thymus: 14.5 nTPM (manageable, limit 5); skin: 14.2 nTPM (manageable, limit 5); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (manageable, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 3); colon: 12.1 nTPM (protected, limit 3); urinary bladder: 12 nTPM (protected, limit 3); rectum: 11.9 nTPM (protected, limit 3); stomach: 11.8 nTPM (protected, limit 3); esophagus: 11.6 nTPM (protected, limit 3); salivary gland: 11.3 nTPM (protected, limit 3); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185658,BRWD1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.0459016,0.03,0.01,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185662,SMIM23,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345902,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185662,SMIM23,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345902,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185662,SMIM23,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345902,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185662,SMIM23,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345902,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185662,SMIM23,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 86.0465% (minimum 95%, Uncertain); adrenal gland: 82.2222% (minimum 99%, Uncertain); amygdala: 64.9123% (minimum 99%, Missing); basal ganglia: 63.7931% (minimum 99%, Missing); bone marrow: 62.7119% (minimum 99%, Uncertain); cerebellum: 74.0000% (minimum 99%, Missing); cerebral cortex: 42.0455% (minimum 99%, Missing); choroid plexus: 88.0952% (minimum 99%, Missing); colon: 88.0952% (minimum 97%, Uncertain); duodenum: 86.0465% (minimum 99%, Uncertain); esophagus: 74.0000% (minimum 97%, Uncertain); heart muscle: 88.0952% (minimum 99%, Uncertain); hippocampal formation: 67.2727% (minimum 99%, Missing); hypothalamus: 66.0714% (minimum 99%, Missing); kidney: 84.0909% (minimum 99%, Uncertain); liver: 90.2439% (minimum 99%, Uncertain); lung: 84.0909% (minimum 99%, Uncertain); lymph node: 78.7234% (minimum 97%, Uncertain); midbrain: 75.5102% (minimum 99%, Missing); pancreas: 84.0909% (minimum 99%, Uncertain); parathyroid gland: 92.5000% (minimum 97%, Uncertain); pituitary gland: 69.8113% (minimum 99%, Missing); rectum: 90.2439% (minimum 97%, Uncertain); retina: 51.3889% (minimum 99%, Missing); salivary gland: 88.0952% (minimum 97%, Uncertain); skeletal muscle: 88.0952% (minimum 99%, Uncertain); skin: 77.0833% (minimum 95%, Uncertain); small intestine: 80.4348% (minimum 99%, Uncertain); smooth muscle: 88.0952% (minimum 99%, Uncertain); spinal cord: 72.5490% (minimum 99%, Missing); spleen: 74.0000% (minimum 95%, Uncertain); stomach: 84.0909% (minimum 97%, Uncertain); thymus: 90.2439% (minimum 95%, Missing); thyroid gland: 86.0465% (minimum 95%, Missing); tongue: 90.2439% (minimum 97%, Missing); urinary bladder: 94.8718% (minimum 97%, Uncertain)",-0.21,-0.23,-0.569545,0,2,partial,5.1,1.3,1.3,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185666,SYN3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 64.9123% (minimum 75%, Missing); basal ganglia: 63.7931% (minimum 75%, Missing); bone marrow: 62.7119% (minimum 75%, Uncertain); cerebellum: 74.0000% (minimum 75%, Missing); cerebral cortex: 42.0455% (minimum 75%, Missing); hippocampal formation: 67.2727% (minimum 75%, Missing); hypothalamus: 66.0714% (minimum 75%, Missing); pituitary gland: 69.8113% (minimum 75%, Missing); retina: 51.3889% (minimum 75%, Missing); spinal cord: 72.5490% (minimum 75%, Missing)",0.09,0.04,-0.329545,0,2,partial,5.1,1.3,1.3,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185666,SYN3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 64.9123% (minimum 75%, Missing); basal ganglia: 63.7931% (minimum 75%, Missing); bone marrow: 62.7119% (minimum 75%, Uncertain); cerebellum: 74.0000% (minimum 75%, Missing); cerebral cortex: 42.0455% (minimum 75%, Missing); hippocampal formation: 67.2727% (minimum 75%, Missing); hypothalamus: 66.0714% (minimum 75%, Missing); pituitary gland: 69.8113% (minimum 75%, Missing); retina: 51.3889% (minimum 75%, Missing); spinal cord: 72.5490% (minimum 75%, Missing)",0.09,0.04,-0.329545,0,2,partial,5.1,1.3,1.3,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185666,SYN3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 64.9123% (minimum 75%, Missing); basal ganglia: 63.7931% (minimum 75%, Missing); bone marrow: 62.7119% (minimum 75%, Uncertain); cerebellum: 74.0000% (minimum 75%, Missing); cerebral cortex: 42.0455% (minimum 75%, Missing); hippocampal formation: 67.2727% (minimum 75%, Missing); hypothalamus: 66.0714% (minimum 75%, Missing); pituitary gland: 69.8113% (minimum 75%, Missing); retina: 51.3889% (minimum 75%, Missing); spinal cord: 72.5490% (minimum 75%, Missing)",0.09,0.04,-0.329545,0,2,partial,5.1,1.3,1.3,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185666,SYN3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 64.9123% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 63.7931% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 62.7119% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 42.0455% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.2727% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.0714% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 69.8113% (minimum 75%, Baseline (adaptation disabled)); retina: 51.3889% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.5490% (minimum 75%, Baseline (adaptation disabled))",0.09,0.04,-0.329545,0,2,partial,5.1,1.3,1.3,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185666,SYN3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.3636% (minimum 95%, Missing); adrenal gland: 76.3636% (minimum 99%, Missing); amygdala: 76.3636% (minimum 99%, Missing); basal ganglia: 73.6842% (minimum 99%, Missing); bone marrow: 64.6154% (minimum 99%, Missing); cerebellum: 73.6842% (minimum 99%, Missing); cerebral cortex: 63.6364% (minimum 99%, Missing); choroid plexus: 84.0000% (minimum 99%, Missing); colon: 64.6154% (minimum 97%, Missing); duodenum: 65.6250% (minimum 99%, Missing); esophagus: 70.0000% (minimum 97%, Missing); heart muscle: 59.1549% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 79.2453% (minimum 99%, Missing); kidney: 71.1864% (minimum 99%, Missing); liver: 71.1864% (minimum 98%, Approved); lung: 60.0000% (minimum 99%, Missing); lymph node: 64.6154% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 63.6364% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 80.7692% (minimum 99%, Missing); rectum: 67.7419% (minimum 97%, Missing); retina: 58.3333% (minimum 99%, Missing); salivary gland: 56.0000% (minimum 97%, Missing); skeletal muscle: 60.8696% (minimum 99%, Missing); skin: 42.8571% (minimum 95%, Missing); small intestine: 65.6250% (minimum 99%, Missing); smooth muscle: 71.1864% (minimum 99%, Missing); spinal cord: 72.4138% (minimum 99%, Missing); spleen: 67.7419% (minimum 90%, Approved); stomach: 46.6667% (minimum 97%, Missing); thymus: 60.8696% (minimum 95%, Missing); thyroid gland: 61.7647% (minimum 95%, Missing); tongue: 57.5342% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.521429,-0.503333,-0.406667,0,1,partial,3,4.8,5.6,"skin: 5.6 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); salivary gland: 3.3 nTPM (protected, limit 2); tongue: 3.1 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185670,ZBTB3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.6842% (minimum 75%, Missing); bone marrow: 64.6154% (minimum 75%, Missing); cerebellum: 73.6842% (minimum 75%, Missing); cerebral cortex: 63.6364% (minimum 75%, Missing); colon: 64.6154% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); heart muscle: 59.1549% (minimum 75%, Missing); kidney: 71.1864% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 64.6154% (minimum 70%, Missing); pancreas: 63.6364% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); rectum: 67.7419% (minimum 70%, Missing); retina: 58.3333% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 60.8696% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 65.6250% (minimum 75%, Missing); smooth muscle: 71.1864% (minimum 75%, Missing); spinal cord: 72.4138% (minimum 75%, Missing); stomach: 46.6667% (minimum 70%, Missing); thymus: 60.8696% (minimum 65%, Missing); thyroid gland: 61.7647% (minimum 65%, Missing); tongue: 57.5342% (minimum 70%, Missing)",-0.221429,-0.233333,-0.166667,0,1,partial,3,4.8,5.6,"skin: 5.6 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); salivary gland: 3.3 nTPM (protected, limit 2); tongue: 3.1 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185670,ZBTB3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.6842% (minimum 75%, Missing); bone marrow: 64.6154% (minimum 75%, Missing); cerebellum: 73.6842% (minimum 75%, Missing); cerebral cortex: 63.6364% (minimum 75%, Missing); colon: 64.6154% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); heart muscle: 59.1549% (minimum 75%, Missing); kidney: 71.1864% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 64.6154% (minimum 70%, Missing); pancreas: 63.6364% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); rectum: 67.7419% (minimum 70%, Missing); retina: 58.3333% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 60.8696% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 65.6250% (minimum 75%, Missing); smooth muscle: 71.1864% (minimum 75%, Missing); spinal cord: 72.4138% (minimum 75%, Missing); stomach: 46.6667% (minimum 70%, Missing); thymus: 60.8696% (minimum 65%, Missing); thyroid gland: 61.7647% (minimum 65%, Missing); tongue: 57.5342% (minimum 70%, Missing)",-0.221429,-0.233333,-0.166667,0,1,partial,3,4.8,5.6,"skin: 5.6 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); salivary gland: 3.3 nTPM (protected, limit 3); tongue: 3.1 nTPM (protected, limit 3); retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185670,ZBTB3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.6842% (minimum 75%, Missing); bone marrow: 64.6154% (minimum 75%, Missing); cerebellum: 73.6842% (minimum 75%, Missing); cerebral cortex: 63.6364% (minimum 75%, Missing); colon: 64.6154% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); heart muscle: 59.1549% (minimum 75%, Missing); kidney: 71.1864% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 64.6154% (minimum 70%, Missing); pancreas: 63.6364% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); rectum: 67.7419% (minimum 70%, Missing); retina: 58.3333% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 60.8696% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 65.6250% (minimum 75%, Missing); smooth muscle: 71.1864% (minimum 75%, Missing); spinal cord: 72.4138% (minimum 75%, Missing); stomach: 46.6667% (minimum 70%, Missing); thymus: 60.8696% (minimum 65%, Missing); thyroid gland: 61.7647% (minimum 65%, Missing); tongue: 57.5342% (minimum 70%, Missing)",-0.221429,-0.233333,-0.166667,0,1,partial,3,4.8,5.6,"skin: 5.6 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); salivary gland: 3.3 nTPM (protected, limit 3); tongue: 3.1 nTPM (protected, limit 3); retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185670,ZBTB3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.6842% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 64.6154% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.6842% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.6364% (minimum 75%, Baseline (adaptation disabled)); colon: 64.6154% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.6250% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 59.1549% (minimum 75%, Baseline (adaptation disabled)); kidney: 71.1864% (minimum 75%, Baseline (adaptation disabled)); liver: 71.1864% (minimum 75%, Baseline (adaptation disabled)); lung: 60.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.6154% (minimum 70%, Baseline (adaptation disabled)); pancreas: 63.6364% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); rectum: 67.7419% (minimum 70%, Baseline (adaptation disabled)); retina: 58.3333% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.8696% (minimum 75%, Baseline (adaptation disabled)); skin: 42.8571% (minimum 65%, Baseline (adaptation disabled)); small intestine: 65.6250% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.1864% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.4138% (minimum 75%, Baseline (adaptation disabled)); stomach: 46.6667% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.8696% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 61.7647% (minimum 65%, Baseline (adaptation disabled)); tongue: 57.5342% (minimum 70%, Baseline (adaptation disabled))",-0.221429,-0.233333,-0.166667,0,1,partial,3,4.8,5.6,"skin: 5.6 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); salivary gland: 3.3 nTPM (protected, limit 3); tongue: 3.1 nTPM (protected, limit 3); retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185670,ZBTB3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0480469,0.03,0.00319728,0,3,partial,3.6,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185686,PRAME,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348047,0.3,0.243197,0,3,partial,3.6,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185686,PRAME,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348047,0.3,0.243197,0,3,partial,3.6,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185686,PRAME,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348047,0.3,0.243197,0,3,partial,3.6,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185686,PRAME,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348047,0.298047,0.215974,0,3,partial,3.6,0.2,0.2,"adrenal gland: 3.6 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185686,PRAME,current_fixed,True,False,False,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.9355% (minimum 95%, Uncertain); adrenal gland: 94.2149% (minimum 99%, Missing); amygdala: 91.9355% (minimum 99%, Missing); basal ganglia: 91.9355% (minimum 99%, Missing); bone marrow: 82.0144% (minimum 99%, Uncertain); cerebellum: 89.0625% (minimum 99%, Missing); cerebral cortex: 88.3721% (minimum 99%, Missing); choroid plexus: 97.4359% (minimum 99%, Missing); colon: 91.9355% (minimum 97%, Missing); duodenum: 90.4762% (minimum 99%, Missing); esophagus: 94.2149% (minimum 97%, Uncertain); heart muscle: 77.5510% (minimum 99%, Uncertain); hippocampal formation: 89.7638% (minimum 99%, Missing); hypothalamus: 92.6829% (minimum 99%, Missing); kidney: 96.6102% (minimum 99%, Missing); liver: 85.0746% (minimum 99%, Uncertain); lung: 83.2117% (minimum 99%, Uncertain); lymph node: 36.6559% (minimum 97%, Uncertain); midbrain: 87.6923% (minimum 99%, Missing); pancreas: 98.2759% (minimum 99%, Missing); parathyroid gland: 96.6102% (minimum 97%, Uncertain); pituitary gland: 96.6102% (minimum 99%, Missing); rectum: 89.0625% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 95.7983% (minimum 97%, Uncertain); skeletal muscle: 92.6829% (minimum 99%, Missing); skin: 90.4762% (minimum 95%, Uncertain); small intestine: 86.3636% (minimum 99%, Missing); smooth muscle: 83.8235% (minimum 99%, Uncertain); spinal cord: 79.7203% (minimum 99%, Missing); spleen: 60.6383% (minimum 95%, Uncertain); stomach: 89.7638% (minimum 97%, Missing); thymus: 82.6087% (minimum 95%, Missing); tongue: 94.2149% (minimum 97%, Missing); urinary bladder: 91.2000% (minimum 97%, Uncertain)",-0.343617,-0.603441,-0.323333,0,3,partial,5.7,19.7,7.4,"lymph node: 19.7 nTPM (protected, limit 2); spleen: 7.4 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185697,MYBL1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 36.6559% (minimum 70%, Uncertain); retina: 66.6667% (minimum 75%, Missing); spleen: 60.6383% (minimum 65%, Uncertain)",-0.043617,-0.333441,-0.0833333,0,3,partial,5.7,19.7,7.4,"lymph node: 19.7 nTPM (protected, limit 2); spleen: 7.4 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185697,MYBL1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 36.6559% (minimum 70%, Uncertain); retina: 66.6667% (minimum 75%, Missing); spleen: 60.6383% (minimum 65%, Uncertain)",-0.043617,-0.333441,-0.0833333,0,3,partial,5.7,19.7,7.4,"lymph node: 19.7 nTPM (protected, limit 3); spleen: 7.4 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185697,MYBL1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 36.6559% (minimum 70%, Uncertain); retina: 66.6667% (minimum 75%, Missing); spleen: 60.6383% (minimum 65%, Uncertain)",-0.043617,-0.333441,-0.0833333,0,3,partial,5.7,19.7,7.4,"lymph node: 19.7 nTPM (protected, limit 3); spleen: 7.4 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185697,MYBL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 36.6559% (minimum 70%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.6383% (minimum 65%, Baseline (adaptation disabled))",-0.043617,-0.333441,-0.0833333,0,3,partial,5.7,19.7,7.4,"lymph node: 19.7 nTPM (protected, limit 3); spleen: 7.4 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185697,MYBL1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.0864% (minimum 95%, Missing); adrenal gland: 57.3333% (minimum 99%, Missing); amygdala: 51.8072% (minimum 99%, Missing); basal ganglia: 51.8072% (minimum 99%, Missing); bone marrow: 55.1282% (minimum 99%, Missing); cerebellum: 44.3299% (minimum 99%, Missing); cerebral cortex: 42.5743% (minimum 99%, Missing); choroid plexus: 72.8814% (minimum 99%, Missing); colon: 57.3333% (minimum 97%, Missing); duodenum: 42.1569% (minimum 99%, Missing); esophagus: 63.2353% (minimum 97%, Missing); heart muscle: 60.5634% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 46.2366% (minimum 99%, Missing); kidney: 57.3333% (minimum 99%, Missing); liver: 48.8636% (minimum 99%, Missing); lung: 61.4286% (minimum 99%, Missing); lymph node: 53.7500% (minimum 97%, Missing); midbrain: 53.0864% (minimum 99%, Missing); pancreas: 46.7391% (minimum 99%, Missing); parathyroid gland: 50.5882% (minimum 97%, Missing); pituitary gland: 58.1081% (minimum 99%, Missing); rectum: 69.3548% (minimum 97%, Missing); retina: 55.1282% (minimum 99%, Missing); salivary gland: 43.8776% (minimum 97%, Missing); skeletal muscle: 53.7500% (minimum 99%, Missing); skin: 40.5660% (minimum 95%, Missing); small intestine: 54.4304% (minimum 99%, Missing); smooth muscle: 66.1538% (minimum 99%, Missing); spinal cord: 54.4304% (minimum 99%, Missing); spleen: 52.4390% (minimum 95%, Missing); stomach: 57.3333% (minimum 97%, Missing); thymus: 67.1875% (minimum 95%, Missing); thyroid gland: 54.4304% (minimum 95%, Missing); tongue: 65.1515% (minimum 97%, Missing); urinary bladder: 54.4304% (minimum 97%, Missing)",-0.54434,-0.531224,-0.568431,0,80,unavailable,5.9,5.5,6.3,"skin: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); spinal cord: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); retina: 3.5 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); tongue: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185730,ZNF696,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.0864% (minimum 65%, Missing); adrenal gland: 57.3333% (minimum 75%, Missing); amygdala: 51.8072% (minimum 75%, Missing); basal ganglia: 51.8072% (minimum 75%, Missing); bone marrow: 55.1282% (minimum 75%, Missing); cerebellum: 44.3299% (minimum 75%, Missing); cerebral cortex: 42.5743% (minimum 75%, Missing); choroid plexus: 72.8814% (minimum 75%, Missing); colon: 57.3333% (minimum 70%, Missing); duodenum: 42.1569% (minimum 75%, Missing); esophagus: 63.2353% (minimum 70%, Missing); heart muscle: 60.5634% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 46.2366% (minimum 75%, Missing); kidney: 57.3333% (minimum 75%, Missing); liver: 48.8636% (minimum 75%, Missing); lung: 61.4286% (minimum 75%, Missing); lymph node: 53.7500% (minimum 70%, Missing); midbrain: 53.0864% (minimum 75%, Missing); pancreas: 46.7391% (minimum 75%, Missing); parathyroid gland: 50.5882% (minimum 70%, Missing); pituitary gland: 58.1081% (minimum 75%, Missing); rectum: 69.3548% (minimum 70%, Missing); retina: 55.1282% (minimum 75%, Missing); salivary gland: 43.8776% (minimum 70%, Missing); skeletal muscle: 53.7500% (minimum 75%, Missing); skin: 40.5660% (minimum 65%, Missing); small intestine: 54.4304% (minimum 75%, Missing); smooth muscle: 66.1538% (minimum 75%, Missing); spinal cord: 54.4304% (minimum 75%, Missing); spleen: 52.4390% (minimum 65%, Missing); stomach: 57.3333% (minimum 70%, Missing); thyroid gland: 54.4304% (minimum 65%, Missing); tongue: 65.1515% (minimum 70%, Missing); urinary bladder: 54.4304% (minimum 70%, Missing)",-0.24434,-0.261224,-0.328431,0,80,unavailable,5.9,5.5,6.3,"skin: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); spinal cord: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); retina: 3.5 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); tongue: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185730,ZNF696,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.0864% (minimum 65%, Missing); adrenal gland: 57.3333% (minimum 75%, Missing); amygdala: 51.8072% (minimum 75%, Missing); basal ganglia: 51.8072% (minimum 75%, Missing); bone marrow: 55.1282% (minimum 75%, Missing); cerebellum: 44.3299% (minimum 75%, Missing); cerebral cortex: 42.5743% (minimum 75%, Missing); choroid plexus: 72.8814% (minimum 75%, Missing); colon: 57.3333% (minimum 70%, Missing); duodenum: 42.1569% (minimum 75%, Missing); esophagus: 63.2353% (minimum 70%, Missing); heart muscle: 60.5634% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 46.2366% (minimum 75%, Missing); kidney: 57.3333% (minimum 75%, Missing); liver: 48.8636% (minimum 75%, Missing); lung: 61.4286% (minimum 75%, Missing); lymph node: 53.7500% (minimum 70%, Missing); midbrain: 53.0864% (minimum 75%, Missing); pancreas: 46.7391% (minimum 75%, Missing); parathyroid gland: 50.5882% (minimum 70%, Missing); pituitary gland: 58.1081% (minimum 75%, Missing); rectum: 69.3548% (minimum 70%, Missing); retina: 55.1282% (minimum 75%, Missing); salivary gland: 43.8776% (minimum 70%, Missing); skeletal muscle: 53.7500% (minimum 75%, Missing); skin: 40.5660% (minimum 65%, Missing); small intestine: 54.4304% (minimum 75%, Missing); smooth muscle: 66.1538% (minimum 75%, Missing); spinal cord: 54.4304% (minimum 75%, Missing); spleen: 52.4390% (minimum 65%, Missing); stomach: 57.3333% (minimum 70%, Missing); thyroid gland: 54.4304% (minimum 65%, Missing); tongue: 65.1515% (minimum 70%, Missing); urinary bladder: 54.4304% (minimum 70%, Missing)",-0.24434,-0.261224,-0.328431,0,80,unavailable,5.9,5.5,6.3,"skin: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185730,ZNF696,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.0864% (minimum 65%, Missing); adrenal gland: 57.3333% (minimum 75%, Missing); amygdala: 51.8072% (minimum 75%, Missing); basal ganglia: 51.8072% (minimum 75%, Missing); bone marrow: 55.1282% (minimum 75%, Missing); cerebellum: 44.3299% (minimum 75%, Missing); cerebral cortex: 42.5743% (minimum 75%, Missing); choroid plexus: 72.8814% (minimum 75%, Missing); colon: 57.3333% (minimum 70%, Missing); duodenum: 42.1569% (minimum 75%, Missing); esophagus: 63.2353% (minimum 70%, Missing); heart muscle: 60.5634% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 46.2366% (minimum 75%, Missing); kidney: 57.3333% (minimum 75%, Missing); liver: 48.8636% (minimum 75%, Missing); lung: 61.4286% (minimum 75%, Missing); lymph node: 53.7500% (minimum 70%, Missing); midbrain: 53.0864% (minimum 75%, Missing); pancreas: 46.7391% (minimum 75%, Missing); parathyroid gland: 50.5882% (minimum 70%, Missing); pituitary gland: 58.1081% (minimum 75%, Missing); rectum: 69.3548% (minimum 70%, Missing); retina: 55.1282% (minimum 75%, Missing); salivary gland: 43.8776% (minimum 70%, Missing); skeletal muscle: 53.7500% (minimum 75%, Missing); skin: 40.5660% (minimum 65%, Missing); small intestine: 54.4304% (minimum 75%, Missing); smooth muscle: 66.1538% (minimum 75%, Missing); spinal cord: 54.4304% (minimum 75%, Missing); spleen: 52.4390% (minimum 65%, Missing); stomach: 57.3333% (minimum 70%, Missing); thyroid gland: 54.4304% (minimum 65%, Missing); tongue: 65.1515% (minimum 70%, Missing); urinary bladder: 54.4304% (minimum 70%, Missing)",-0.24434,-0.261224,-0.328431,0,80,unavailable,5.9,5.5,6.3,"skin: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185730,ZNF696,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.0864% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 57.3333% (minimum 75%, Baseline (adaptation disabled)); amygdala: 51.8072% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 51.8072% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 55.1282% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 44.3299% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 42.5743% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.8814% (minimum 75%, Baseline (adaptation disabled)); colon: 57.3333% (minimum 70%, Baseline (adaptation disabled)); duodenum: 42.1569% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.2353% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.5634% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 46.2366% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.3333% (minimum 75%, Baseline (adaptation disabled)); liver: 48.8636% (minimum 75%, Baseline (adaptation disabled)); lung: 61.4286% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.7500% (minimum 70%, Baseline (adaptation disabled)); midbrain: 53.0864% (minimum 75%, Baseline (adaptation disabled)); pancreas: 46.7391% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.5882% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.1081% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.3548% (minimum 70%, Baseline (adaptation disabled)); retina: 55.1282% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 43.8776% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 53.7500% (minimum 75%, Baseline (adaptation disabled)); skin: 40.5660% (minimum 65%, Baseline (adaptation disabled)); small intestine: 54.4304% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.1538% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 54.4304% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.4390% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.3333% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 54.4304% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.1515% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 54.4304% (minimum 70%, Baseline (adaptation disabled))",-0.24434,-0.261224,-0.328431,0,80,unavailable,5.9,5.5,6.3,"skin: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185730,ZNF696,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185775,SPATA31A6,admission_only,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185775,SPATA31A6,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185775,SPATA31A6,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185775,SPATA31A6,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185775,SPATA31A6,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"bone marrow: 95.2381% (minimum 99%, Missing); kidney: 95.2381% (minimum 99%, Missing)",0.05,0.03,-0.037619,0,2,unreliable,0.1,0,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / Langerhans; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185792,NLRP9,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.202381,0,2,unreliable,0.1,0,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / Langerhans; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185792,NLRP9,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.202381,0,2,unreliable,0.1,0,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / Langerhans; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185792,NLRP9,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.202381,0,2,unreliable,0.1,0,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / Langerhans; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185792,NLRP9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.202381,0,2,unreliable,0.1,0,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / Langerhans; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185792,NLRP9,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.0354% (minimum 99%, Missing); amygdala: 92.3175% (minimum 99%, Missing); basal ganglia: 91.3815% (minimum 99%, Missing); bone marrow: 83.2564% (minimum 98%, Approved); cerebellum: 91.1504% (minimum 98%, Approved); cerebral cortex: 92.4359% (minimum 99%, Missing); choroid plexus: 86.2440% (minimum 99%, Missing); colon: 90.2378% (minimum 97%, Missing); duodenum: 94.4954% (minimum 99%, Missing); esophagus: 89.2327% (minimum 95%, Approved); heart muscle: 90.2378% (minimum 98%, Approved); hippocampal formation: 91.8471% (minimum 99%, Missing); hypothalamus: 91.9643% (minimum 99%, Missing); kidney: 89.3432% (minimum 99%, Missing); liver: 88.1418% (minimum 98%, Approved); lung: 91.4975% (minimum 98%, Approved); lymph node: 87.5000% (minimum 95%, Approved); midbrain: 91.8471% (minimum 99%, Missing); pancreas: 92.6735% (minimum 99%, Missing); parathyroid gland: 88.2497% (minimum 97%, Missing); pituitary gland: 91.7303% (minimum 99%, Missing); rectum: 91.2658% (minimum 97%, Missing); retina: 89.3432% (minimum 99%, Missing); salivary gland: 91.3815% (minimum 97%, Missing); skeletal muscle: 85.1240% (minimum 98%, Approved); skin: 86.1410% (minimum 90%, Approved); small intestine: 90.3509% (minimum 99%, Missing); smooth muscle: 91.0354% (minimum 98%, Approved); spinal cord: 91.4975% (minimum 99%, Missing); spleen: 87.1826% (minimum 90%, Approved); stomach: 91.1504% (minimum 97%, Missing); thymus: 85.9356% (minimum 95%, Missing); thyroid gland: 91.2658% (minimum 95%, Missing); tongue: 85.6295% (minimum 97%, Missing); urinary bladder: 91.1504% (minimum 97%, Missing)",-0.0906436,-0.113705,-0.147436,0,5,partial,14.5,12.1,11.8,"bone marrow: 14.5 nTPM (vital, limit 2); skeletal muscle: 12.6 nTPM (vital, limit 2); tongue: 12.1 nTPM (protected, limit 2); thymus: 11.8 nTPM (manageable, limit 5); skin: 11.6 nTPM (manageable, limit 10); choroid plexus: 11.5 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 10); lymph node: 10.3 nTPM (protected, limit 4); liver: 9.7 nTPM (vital, limit 2); parathyroid gland: 9.6 nTPM (protected, limit 2); esophagus: 8.7 nTPM (protected, limit 4); kidney: 8.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 2); colon: 7.8 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 2); adrenal gland: 7.1 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); urinary bladder: 7 nTPM (protected, limit 2); cerebellum: 7 nTPM (vital, limit 2); rectum: 6.9 nTPM (protected, limit 2); thyroid gland: 6.9 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 2); spinal cord: 6.7 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185798,WDR53,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.209356,0.156295,0.11244,0,5,partial,14.5,12.1,11.8,"bone marrow: 14.5 nTPM (vital, limit 2); skeletal muscle: 12.6 nTPM (vital, limit 2); tongue: 12.1 nTPM (protected, limit 2); thymus: 11.8 nTPM (manageable, limit 5); skin: 11.6 nTPM (manageable, limit 10); choroid plexus: 11.5 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 10); lymph node: 10.3 nTPM (protected, limit 4); liver: 9.7 nTPM (vital, limit 2); parathyroid gland: 9.6 nTPM (protected, limit 2); esophagus: 8.7 nTPM (protected, limit 4); kidney: 8.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 2); colon: 7.8 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 2); adrenal gland: 7.1 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); urinary bladder: 7 nTPM (protected, limit 2); cerebellum: 7 nTPM (vital, limit 2); rectum: 6.9 nTPM (protected, limit 2); thyroid gland: 6.9 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 2); spinal cord: 6.7 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185798,WDR53,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.209356,0.156295,0.11244,0,5,partial,14.5,12.1,11.8,"bone marrow: 14.5 nTPM (vital, limit 2); skeletal muscle: 12.6 nTPM (vital, limit 2); tongue: 12.1 nTPM (protected, limit 3); thymus: 11.8 nTPM (manageable, limit 5); skin: 11.6 nTPM (manageable, limit 10); choroid plexus: 11.5 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 10); lymph node: 10.3 nTPM (protected, limit 4); liver: 9.7 nTPM (vital, limit 2); parathyroid gland: 9.6 nTPM (protected, limit 3); esophagus: 8.7 nTPM (protected, limit 4); kidney: 8.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 2); colon: 7.8 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 2); adrenal gland: 7.1 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 3); urinary bladder: 7 nTPM (protected, limit 3); cerebellum: 7 nTPM (vital, limit 2); rectum: 6.9 nTPM (protected, limit 3); thyroid gland: 6.9 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 3); basal ganglia: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 2); spinal cord: 6.7 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185798,WDR53,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.209356,0.156295,0.11244,0,5,partial,14.5,12.1,11.8,"bone marrow: 14.5 nTPM (vital, limit 2); skeletal muscle: 12.6 nTPM (vital, limit 2); tongue: 12.1 nTPM (protected, limit 3); thymus: 11.8 nTPM (manageable, limit 5); skin: 11.6 nTPM (manageable, limit 10); choroid plexus: 11.5 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 10); lymph node: 10.3 nTPM (protected, limit 4); liver: 9.7 nTPM (vital, limit 2); parathyroid gland: 9.6 nTPM (protected, limit 3); esophagus: 8.7 nTPM (protected, limit 4); kidney: 8.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 2); colon: 7.8 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 2); adrenal gland: 7.1 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 3); urinary bladder: 7 nTPM (protected, limit 3); cerebellum: 7 nTPM (vital, limit 2); rectum: 6.9 nTPM (protected, limit 3); thyroid gland: 6.9 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 3); basal ganglia: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 2); spinal cord: 6.7 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185798,WDR53,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.209356,0.156295,0.0825635,0,5,partial,14.5,12.1,11.8,"bone marrow: 14.5 nTPM (vital, limit 1); skeletal muscle: 12.6 nTPM (vital, limit 1); tongue: 12.1 nTPM (protected, limit 3); thymus: 11.8 nTPM (manageable, limit 5); skin: 11.6 nTPM (manageable, limit 5); choroid plexus: 11.5 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 3); liver: 9.7 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 3); esophagus: 8.7 nTPM (protected, limit 3); kidney: 8.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 1); colon: 7.8 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); adipose tissue: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.1 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 3); urinary bladder: 7 nTPM (protected, limit 3); cerebellum: 7 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 3); thyroid gland: 6.9 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 3); basal ganglia: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185798,WDR53,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 84.8485% (minimum 99%, Missing); duodenum: 96.5517% (minimum 99%, Missing); hypothalamus: 90.3226% (minimum 99%, Missing); kidney: 77.7778% (minimum 99%, Missing); lymph node: 96.5517% (minimum 97%, Missing); midbrain: 96.5517% (minimum 99%, Missing); pancreas: 87.5000% (minimum 99%, Missing); pituitary gland: 87.5000% (minimum 99%, Missing); retina: 93.3333% (minimum 99%, Missing); skeletal muscle: 96.5517% (minimum 99%, Missing); skin: 93.3333% (minimum 95%, Missing); spinal cord: 93.3333% (minimum 99%, Missing); stomach: 96.5517% (minimum 97%, Missing); thyroid gland: 84.8485% (minimum 95%, Missing); urinary bladder: 96.5517% (minimum 97%, Missing)",-0.101515,-0.00448276,-0.212222,0,80,unavailable,0.8,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185823,NPAP1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.198485,0.265517,0.0277778,0,80,unavailable,0.8,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185823,NPAP1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.198485,0.265517,0.0277778,0,80,unavailable,0.8,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185823,NPAP1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.198485,0.265517,0.0277778,0,80,unavailable,0.8,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185823,NPAP1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.198485,0.265517,0.0277778,0,80,unavailable,0.8,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185823,NPAP1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.4275% (minimum 95%, Uncertain); adrenal gland: 77.2277% (minimum 99%, Missing); amygdala: 88.0361% (minimum 99%, Missing); basal ganglia: 86.6667% (minimum 99%, Missing); bone marrow: 68.4211% (minimum 99%, Uncertain); cerebellum: 73.4463% (minimum 99%, Missing); cerebral cortex: 80.4124% (minimum 99%, Missing); choroid plexus: 63.6215% (minimum 99%, Missing); colon: 75.7282% (minimum 97%, Missing); duodenum: 84.2333% (minimum 99%, Missing); esophagus: 79.9180% (minimum 97%, Missing); heart muscle: 78.7879% (minimum 99%, Missing); hippocampal formation: 85.9031% (minimum 99%, Missing); hypothalamus: 86.8597% (minimum 99%, Missing); kidney: 75.2896% (minimum 99%, Missing); liver: 73.3083% (minimum 99%, Missing); lung: 74.8560% (minimum 99%, Missing); lymph node: 70.7804% (minimum 97%, Missing); midbrain: 88.8383% (minimum 99%, Missing); pancreas: 80.9129% (minimum 99%, Missing); parathyroid gland: 64.4628% (minimum 97%, Missing); pituitary gland: 75.0000% (minimum 99%, Missing); rectum: 68.3012% (minimum 97%, Missing); retina: 53.7190% (minimum 99%, Missing); salivary gland: 78.0000% (minimum 97%, Uncertain); skeletal muscle: 69.2718% (minimum 99%, Uncertain); skin: 68.9046% (minimum 95%, Missing); small intestine: 80.9129% (minimum 99%, Missing); smooth muscle: 67.3575% (minimum 99%, Missing); spinal cord: 85.9031% (minimum 99%, Missing); spleen: 73.0337% (minimum 95%, Missing); stomach: 79.1075% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 68.4211% (minimum 95%, Missing); tongue: 66.3265% (minimum 97%, Missing); urinary bladder: 78.9474% (minimum 97%, Missing)",-0.283333,-0.325372,-0.45281,0,6,partial,33.6,21.5,19.5,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 2); tongue: 19.8 nTPM (protected, limit 2); thymus: 19.5 nTPM (manageable, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 2); thyroid gland: 18 nTPM (manageable, limit 5); bone marrow: 18 nTPM (vital, limit 1); skin: 17.6 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 2); spleen: 14.4 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); salivary gland: 11 nTPM (protected, limit 2); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); stomach: 10.3 nTPM (protected, limit 2); esophagus: 9.8 nTPM (protected, limit 2); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185829,ARL17A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 68.4211% (minimum 75%, Uncertain); cerebellum: 73.4463% (minimum 75%, Missing); choroid plexus: 63.6215% (minimum 75%, Missing); liver: 73.3083% (minimum 75%, Missing); lung: 74.8560% (minimum 75%, Missing); parathyroid gland: 64.4628% (minimum 70%, Missing); rectum: 68.3012% (minimum 70%, Missing); retina: 53.7190% (minimum 75%, Missing); skeletal muscle: 69.2718% (minimum 75%, Uncertain); smooth muscle: 67.3575% (minimum 75%, Missing); tongue: 66.3265% (minimum 70%, Missing)",0.0166667,-0.0553719,-0.21281,0,6,partial,33.6,21.5,19.5,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 2); tongue: 19.8 nTPM (protected, limit 2); thymus: 19.5 nTPM (manageable, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 2); thyroid gland: 18 nTPM (manageable, limit 5); bone marrow: 18 nTPM (vital, limit 1); skin: 17.6 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 2); spleen: 14.4 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); salivary gland: 11 nTPM (protected, limit 2); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); stomach: 10.3 nTPM (protected, limit 2); esophagus: 9.8 nTPM (protected, limit 2); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185829,ARL17A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 68.4211% (minimum 75%, Uncertain); cerebellum: 73.4463% (minimum 75%, Missing); choroid plexus: 63.6215% (minimum 75%, Missing); liver: 73.3083% (minimum 75%, Missing); lung: 74.8560% (minimum 75%, Missing); parathyroid gland: 64.4628% (minimum 70%, Missing); rectum: 68.3012% (minimum 70%, Missing); retina: 53.7190% (minimum 75%, Missing); skeletal muscle: 69.2718% (minimum 75%, Uncertain); smooth muscle: 67.3575% (minimum 75%, Missing); tongue: 66.3265% (minimum 70%, Missing)",0.0166667,-0.0553719,-0.21281,0,6,partial,33.6,21.5,19.5,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 3); tongue: 19.8 nTPM (protected, limit 3); thymus: 19.5 nTPM (manageable, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 3); thyroid gland: 18 nTPM (manageable, limit 5); bone marrow: 18 nTPM (vital, limit 1); skin: 17.6 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 3); spleen: 14.4 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); salivary gland: 11 nTPM (protected, limit 3); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); stomach: 10.3 nTPM (protected, limit 3); esophagus: 9.8 nTPM (protected, limit 3); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185829,ARL17A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 68.4211% (minimum 75%, Uncertain); cerebellum: 73.4463% (minimum 75%, Missing); choroid plexus: 63.6215% (minimum 75%, Missing); liver: 73.3083% (minimum 75%, Missing); lung: 74.8560% (minimum 75%, Missing); parathyroid gland: 64.4628% (minimum 70%, Missing); rectum: 68.3012% (minimum 70%, Missing); retina: 53.7190% (minimum 75%, Missing); skeletal muscle: 69.2718% (minimum 75%, Uncertain); smooth muscle: 67.3575% (minimum 75%, Missing); tongue: 66.3265% (minimum 70%, Missing)",0.0166667,-0.0553719,-0.21281,0,6,partial,33.6,21.5,19.5,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 3); tongue: 19.8 nTPM (protected, limit 3); thymus: 19.5 nTPM (manageable, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 3); thyroid gland: 18 nTPM (manageable, limit 5); bone marrow: 18 nTPM (vital, limit 1); skin: 17.6 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 3); spleen: 14.4 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); salivary gland: 11 nTPM (protected, limit 3); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); stomach: 10.3 nTPM (protected, limit 3); esophagus: 9.8 nTPM (protected, limit 3); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185829,ARL17A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 68.4211% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.4463% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 63.6215% (minimum 75%, Baseline (adaptation disabled)); liver: 73.3083% (minimum 75%, Baseline (adaptation disabled)); lung: 74.8560% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.4628% (minimum 70%, Baseline (adaptation disabled)); rectum: 68.3012% (minimum 70%, Baseline (adaptation disabled)); retina: 53.7190% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 69.2718% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.3575% (minimum 75%, Baseline (adaptation disabled)); tongue: 66.3265% (minimum 70%, Baseline (adaptation disabled))",0.0166667,-0.0553719,-0.21281,0,6,partial,33.6,21.5,19.5,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 3); tongue: 19.8 nTPM (protected, limit 3); thymus: 19.5 nTPM (manageable, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 3); thyroid gland: 18 nTPM (manageable, limit 5); bone marrow: 18 nTPM (vital, limit 1); skin: 17.6 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 3); spleen: 14.4 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); salivary gland: 11 nTPM (protected, limit 3); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); stomach: 10.3 nTPM (protected, limit 3); esophagus: 9.8 nTPM (protected, limit 3); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185829,ARL17A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.3984% (minimum 99%, Missing); amygdala: 93.0736% (minimum 99%, Missing); basal ganglia: 95.1327% (minimum 99%, Missing); bone marrow: 92.2747% (minimum 99%, Uncertain); cerebellum: 98.6239% (minimum 99%, Uncertain); cerebral cortex: 93.0736% (minimum 99%, Uncertain); choroid plexus: 89.9582% (minimum 99%, Missing); colon: 92.2747% (minimum 97%, Missing); duodenum: 95.5556% (minimum 99%, Uncertain); esophagus: 95.1327% (minimum 97%, Uncertain); heart muscle: 94.2982% (minimum 99%, Uncertain); hippocampal formation: 93.0736% (minimum 99%, Missing); hypothalamus: 84.3137% (minimum 99%, Missing); kidney: 80.2239% (minimum 99%, Missing); liver: 79.6296% (minimum 99%, Uncertain); lung: 90.7173% (minimum 99%, Uncertain); midbrain: 92.2747% (minimum 99%, Missing); pancreas: 79.6296% (minimum 99%, Uncertain); parathyroid gland: 91.8803% (minimum 97%, Uncertain); pituitary gland: 77.0609% (minimum 99%, Missing); rectum: 90.7173% (minimum 97%, Uncertain); retina: 89.2116% (minimum 99%, Missing); salivary gland: 93.8865% (minimum 97%, Uncertain); small intestine: 97.2851% (minimum 99%, Uncertain); smooth muscle: 95.5556% (minimum 99%, Uncertain); spinal cord: 87.3984% (minimum 99%, Missing); stomach: 89.5833% (minimum 97%, Uncertain); thymus: 94.2982% (minimum 95%, Missing); thyroid gland: 83.6576% (minimum 95%, Uncertain); urinary bladder: 92.2747% (minimum 97%, Uncertain)",-0.113424,-0.0741667,-0.219391,0,3,partial,6.4,2.5,4.2,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185842,DNAH14,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.186576,0.195833,0.0206093,0,3,partial,6.4,2.5,4.2,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185842,DNAH14,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.186576,0.195833,0.0206093,0,3,partial,6.4,2.5,4.2,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185842,DNAH14,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.186576,0.195833,0.0206093,0,3,partial,6.4,2.5,4.2,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185842,DNAH14,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.186576,0.195833,0.0206093,0,3,partial,6.4,2.5,4.2,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185842,DNAH14,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0.2,1.4,0,,,55,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185863,TMEM210,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.2,1.4,0,,,55,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185863,TMEM210,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.2,1.4,0,,,55,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185863,TMEM210,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.2,1.4,0,,,55,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185863,TMEM210,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.211392,0.236301,0,1,partial,0.2,1.4,0,,,55,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185863,TMEM210,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.5282% (minimum 95%, Missing); adrenal gland: 45.6176% (minimum 99%, Missing); amygdala: 35.4634% (minimum 99%, Missing); basal ganglia: 34.0508% (minimum 99%, Missing); bone marrow: 52.7020% (minimum 99%, Missing); cerebellum: 30.4302% (minimum 99%, Missing); cerebral cortex: 25.4079% (minimum 99%, Missing); choroid plexus: 47.6857% (minimum 99%, Missing); colon: 54.6072% (minimum 97%, Missing); duodenum: 68.5432% (minimum 99%, Missing); esophagus: 38.0204% (minimum 97%, Missing); heart muscle: 49.5193% (minimum 99%, Missing); hippocampal formation: 34.1550% (minimum 99%, Missing); hypothalamus: 32.9398% (minimum 99%, Missing); kidney: 33.2726% (minimum 99%, Missing); liver: 49.8759% (minimum 99%, Missing); lung: 47.3374% (minimum 99%, Missing); lymph node: 80.1996% (minimum 97%, Missing); midbrain: 38.4424% (minimum 99%, Missing); pancreas: 59.5612% (minimum 99%, Missing); parathyroid gland: 66.7220% (minimum 97%, Missing); pituitary gland: 38.6792% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 65.2273% (minimum 99%, Missing); salivary gland: 49.1559% (minimum 97%, Missing); skeletal muscle: 40.8915% (minimum 99%, Missing); skin: 42.4377% (minimum 95%, Missing); small intestine: 55.6973% (minimum 99%, Missing); smooth muscle: 87.4619% (minimum 99%, Missing); spinal cord: 42.6720% (minimum 99%, Missing); spleen: 48.1198% (minimum 95%, Missing); stomach: 54.0926% (minimum 97%, Missing); thymus: 82.1341% (minimum 95%, Missing); thyroid gland: 55.4054% (minimum 95%, Missing); tongue: 79.5014% (minimum 97%, Missing); urinary bladder: 60.7132% (minimum 97%, Missing)",-0.525623,-0.589796,-0.735921,0,80,unavailable,589.8,327.5,272.5,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 2); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); skin: 272.5 nTPM (manageable, limit 5); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); spleen: 216.6 nTPM (manageable, limit 5); salivary gland: 207.8 nTPM (protected, limit 2); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (manageable, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 2); colon: 167 nTPM (protected, limit 2); thyroid gland: 161.7 nTPM (manageable, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 2); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 2); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 2); lymph node: 49.6 nTPM (protected, limit 2); thymus: 43.7 nTPM (manageable, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185883,ATP6V0C,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.5282% (minimum 65%, Missing); adrenal gland: 45.6176% (minimum 75%, Missing); amygdala: 35.4634% (minimum 75%, Missing); basal ganglia: 34.0508% (minimum 75%, Missing); bone marrow: 52.7020% (minimum 75%, Missing); cerebellum: 30.4302% (minimum 75%, Missing); cerebral cortex: 25.4079% (minimum 75%, Missing); choroid plexus: 47.6857% (minimum 75%, Missing); colon: 54.6072% (minimum 70%, Missing); duodenum: 68.5432% (minimum 75%, Missing); esophagus: 38.0204% (minimum 70%, Missing); heart muscle: 49.5193% (minimum 75%, Missing); hippocampal formation: 34.1550% (minimum 75%, Missing); hypothalamus: 32.9398% (minimum 75%, Missing); kidney: 33.2726% (minimum 75%, Missing); liver: 49.8759% (minimum 75%, Missing); lung: 47.3374% (minimum 75%, Missing); midbrain: 38.4424% (minimum 75%, Missing); pancreas: 59.5612% (minimum 75%, Missing); parathyroid gland: 66.7220% (minimum 70%, Missing); pituitary gland: 38.6792% (minimum 75%, Missing); retina: 65.2273% (minimum 75%, Missing); salivary gland: 49.1559% (minimum 70%, Missing); skeletal muscle: 40.8915% (minimum 75%, Missing); skin: 42.4377% (minimum 65%, Missing); small intestine: 55.6973% (minimum 75%, Missing); spinal cord: 42.6720% (minimum 75%, Missing); spleen: 48.1198% (minimum 65%, Missing); stomach: 54.0926% (minimum 70%, Missing); thyroid gland: 55.4054% (minimum 65%, Missing); urinary bladder: 60.7132% (minimum 70%, Missing)",-0.225623,-0.319796,-0.495921,0,80,unavailable,589.8,327.5,272.5,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 2); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); skin: 272.5 nTPM (manageable, limit 5); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); spleen: 216.6 nTPM (manageable, limit 5); salivary gland: 207.8 nTPM (protected, limit 2); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (manageable, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 2); colon: 167 nTPM (protected, limit 2); thyroid gland: 161.7 nTPM (manageable, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 2); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 2); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 2); lymph node: 49.6 nTPM (protected, limit 2); thymus: 43.7 nTPM (manageable, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185883,ATP6V0C,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.5282% (minimum 65%, Missing); adrenal gland: 45.6176% (minimum 75%, Missing); amygdala: 35.4634% (minimum 75%, Missing); basal ganglia: 34.0508% (minimum 75%, Missing); bone marrow: 52.7020% (minimum 75%, Missing); cerebellum: 30.4302% (minimum 75%, Missing); cerebral cortex: 25.4079% (minimum 75%, Missing); choroid plexus: 47.6857% (minimum 75%, Missing); colon: 54.6072% (minimum 70%, Missing); duodenum: 68.5432% (minimum 75%, Missing); esophagus: 38.0204% (minimum 70%, Missing); heart muscle: 49.5193% (minimum 75%, Missing); hippocampal formation: 34.1550% (minimum 75%, Missing); hypothalamus: 32.9398% (minimum 75%, Missing); kidney: 33.2726% (minimum 75%, Missing); liver: 49.8759% (minimum 75%, Missing); lung: 47.3374% (minimum 75%, Missing); midbrain: 38.4424% (minimum 75%, Missing); pancreas: 59.5612% (minimum 75%, Missing); parathyroid gland: 66.7220% (minimum 70%, Missing); pituitary gland: 38.6792% (minimum 75%, Missing); retina: 65.2273% (minimum 75%, Missing); salivary gland: 49.1559% (minimum 70%, Missing); skeletal muscle: 40.8915% (minimum 75%, Missing); skin: 42.4377% (minimum 65%, Missing); small intestine: 55.6973% (minimum 75%, Missing); spinal cord: 42.6720% (minimum 75%, Missing); spleen: 48.1198% (minimum 65%, Missing); stomach: 54.0926% (minimum 70%, Missing); thyroid gland: 55.4054% (minimum 65%, Missing); urinary bladder: 60.7132% (minimum 70%, Missing)",-0.225623,-0.319796,-0.495921,0,80,unavailable,589.8,327.5,272.5,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 3); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); skin: 272.5 nTPM (manageable, limit 5); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); spleen: 216.6 nTPM (manageable, limit 5); salivary gland: 207.8 nTPM (protected, limit 3); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (manageable, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 3); colon: 167 nTPM (protected, limit 3); thyroid gland: 161.7 nTPM (manageable, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 3); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 3); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 3); lymph node: 49.6 nTPM (protected, limit 3); thymus: 43.7 nTPM (manageable, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185883,ATP6V0C,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.5282% (minimum 65%, Missing); adrenal gland: 45.6176% (minimum 75%, Missing); amygdala: 35.4634% (minimum 75%, Missing); basal ganglia: 34.0508% (minimum 75%, Missing); bone marrow: 52.7020% (minimum 75%, Missing); cerebellum: 30.4302% (minimum 75%, Missing); cerebral cortex: 25.4079% (minimum 75%, Missing); choroid plexus: 47.6857% (minimum 75%, Missing); colon: 54.6072% (minimum 70%, Missing); duodenum: 68.5432% (minimum 75%, Missing); esophagus: 38.0204% (minimum 70%, Missing); heart muscle: 49.5193% (minimum 75%, Missing); hippocampal formation: 34.1550% (minimum 75%, Missing); hypothalamus: 32.9398% (minimum 75%, Missing); kidney: 33.2726% (minimum 75%, Missing); liver: 49.8759% (minimum 75%, Missing); lung: 47.3374% (minimum 75%, Missing); midbrain: 38.4424% (minimum 75%, Missing); pancreas: 59.5612% (minimum 75%, Missing); parathyroid gland: 66.7220% (minimum 70%, Missing); pituitary gland: 38.6792% (minimum 75%, Missing); retina: 65.2273% (minimum 75%, Missing); salivary gland: 49.1559% (minimum 70%, Missing); skeletal muscle: 40.8915% (minimum 75%, Missing); skin: 42.4377% (minimum 65%, Missing); small intestine: 55.6973% (minimum 75%, Missing); spinal cord: 42.6720% (minimum 75%, Missing); spleen: 48.1198% (minimum 65%, Missing); stomach: 54.0926% (minimum 70%, Missing); thyroid gland: 55.4054% (minimum 65%, Missing); urinary bladder: 60.7132% (minimum 70%, Missing)",-0.225623,-0.319796,-0.495921,0,80,unavailable,589.8,327.5,272.5,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 3); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); skin: 272.5 nTPM (manageable, limit 5); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); spleen: 216.6 nTPM (manageable, limit 5); salivary gland: 207.8 nTPM (protected, limit 3); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (manageable, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 3); colon: 167 nTPM (protected, limit 3); thyroid gland: 161.7 nTPM (manageable, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 3); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 3); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 3); lymph node: 49.6 nTPM (protected, limit 3); thymus: 43.7 nTPM (manageable, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185883,ATP6V0C,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.5282% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 45.6176% (minimum 75%, Baseline (adaptation disabled)); amygdala: 35.4634% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 34.0508% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 52.7020% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 30.4302% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 25.4079% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 47.6857% (minimum 75%, Baseline (adaptation disabled)); colon: 54.6072% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.5432% (minimum 75%, Baseline (adaptation disabled)); esophagus: 38.0204% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 49.5193% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 34.1550% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 32.9398% (minimum 75%, Baseline (adaptation disabled)); kidney: 33.2726% (minimum 75%, Baseline (adaptation disabled)); liver: 49.8759% (minimum 75%, Baseline (adaptation disabled)); lung: 47.3374% (minimum 75%, Baseline (adaptation disabled)); midbrain: 38.4424% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.5612% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.7220% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 38.6792% (minimum 75%, Baseline (adaptation disabled)); retina: 65.2273% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 49.1559% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 40.8915% (minimum 75%, Baseline (adaptation disabled)); skin: 42.4377% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.6973% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 42.6720% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.1198% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.0926% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 55.4054% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 60.7132% (minimum 70%, Baseline (adaptation disabled))",-0.225623,-0.319796,-0.495921,0,80,unavailable,589.8,327.5,272.5,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 3); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); skin: 272.5 nTPM (manageable, limit 5); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); spleen: 216.6 nTPM (manageable, limit 5); salivary gland: 207.8 nTPM (protected, limit 3); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (manageable, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 3); colon: 167 nTPM (protected, limit 3); thyroid gland: 161.7 nTPM (manageable, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 3); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 3); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 3); lymph node: 49.6 nTPM (protected, limit 3); thymus: 43.7 nTPM (manageable, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185883,ATP6V0C,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 97.6190% (minimum 99%, Missing)",0.05,0.03,-0.0138095,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185888,PRSS38,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22619,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185888,PRSS38,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22619,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185888,PRSS38,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22619,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185888,PRSS38,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22619,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185888,PRSS38,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 84.6154% (minimum 99%, Missing)",0.05,0.03,-0.143846,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000185894,BPY2C,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000185894,BPY2C,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000185894,BPY2C,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000185894,BPY2C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000185894,BPY2C,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.4479% (minimum 95%, Missing); adrenal gland: 90.1015% (minimum 99%, Missing); amygdala: 96.9945% (minimum 99%, Missing); basal ganglia: 95.9459% (minimum 99%, Missing); bone marrow: 98.0663% (minimum 99%, Missing); cerebellum: 85.7488% (minimum 99%, Missing); cerebral cortex: 82.7506% (minimum 99%, Missing); choroid plexus: 94.9198% (minimum 99%, Missing); colon: 70.4365% (minimum 97%, Missing); duodenum: 79.2411% (minimum 99%, Missing); esophagus: 90.1015% (minimum 97%, Missing); heart muscle: 92.9319% (minimum 99%, Missing); hippocampal formation: 97.7961% (minimum 99%, Missing); hypothalamus: 96.7302% (minimum 99%, Missing); kidney: 86.3747% (minimum 99%, Missing); liver: 93.4211% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 92.6893% (minimum 97%, Missing); midbrain: 97.5275% (minimum 99%, Missing); pancreas: 82.3666% (minimum 99%, Missing); parathyroid gland: 91.4948% (minimum 97%, Missing); pituitary gland: 97.7961% (minimum 99%, Missing); rectum: 68.9320% (minimum 97%, Missing); retina: 81.4220% (minimum 99%, Missing); salivary gland: 80.8656% (minimum 97%, Missing); skeletal muscle: 92.9319% (minimum 99%, Missing); skin: 91.0256% (minimum 95%, Missing); small intestine: 71.1423% (minimum 99%, Missing); smooth muscle: 92.6893% (minimum 99%, Missing); spinal cord: 98.0663% (minimum 99%, Missing); spleen: 90.3308% (minimum 95%, Missing); stomach: 68.6654% (minimum 97%, Missing); thymus: 93.1759% (minimum 95%, Missing); thyroid gland: 84.7255% (minimum 95%, Missing); tongue: 85.1319% (minimum 97%, Missing); urinary bladder: 85.1319% (minimum 97%, Missing)",-0.102745,-0.283346,-0.278577,0,3,partial,14.4,16.2,6.4,"stomach: 16.2 nTPM (protected, limit 2); rectum: 16 nTPM (protected, limit 2); colon: 14.9 nTPM (protected, limit 2); small intestine: 14.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 2); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); adrenal gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185920,PTCH1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"rectum: 68.9320% (minimum 70%, Missing); small intestine: 71.1423% (minimum 75%, Missing); stomach: 68.6654% (minimum 70%, Missing)",0.197255,-0.0133462,-0.0385772,0,3,partial,14.4,16.2,6.4,"stomach: 16.2 nTPM (protected, limit 2); rectum: 16 nTPM (protected, limit 2); colon: 14.9 nTPM (protected, limit 2); small intestine: 14.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 2); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); adrenal gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185920,PTCH1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"rectum: 68.9320% (minimum 70%, Missing); small intestine: 71.1423% (minimum 75%, Missing); stomach: 68.6654% (minimum 70%, Missing)",0.197255,-0.0133462,-0.0385772,0,3,partial,14.4,16.2,6.4,"stomach: 16.2 nTPM (protected, limit 3); rectum: 16 nTPM (protected, limit 3); colon: 14.9 nTPM (protected, limit 3); small intestine: 14.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 3); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); adrenal gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185920,PTCH1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"rectum: 68.9320% (minimum 70%, Missing); small intestine: 71.1423% (minimum 75%, Missing); stomach: 68.6654% (minimum 70%, Missing)",0.197255,-0.0133462,-0.0385772,0,3,partial,14.4,16.2,6.4,"stomach: 16.2 nTPM (protected, limit 3); rectum: 16 nTPM (protected, limit 3); colon: 14.9 nTPM (protected, limit 3); small intestine: 14.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 3); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); adrenal gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185920,PTCH1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"rectum: 68.9320% (minimum 70%, Baseline (adaptation disabled)); small intestine: 71.1423% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.6654% (minimum 70%, Baseline (adaptation disabled))",0.197255,-0.0133462,-0.0385772,0,3,partial,14.4,16.2,6.4,"stomach: 16.2 nTPM (protected, limit 3); rectum: 16 nTPM (protected, limit 3); colon: 14.9 nTPM (protected, limit 3); small intestine: 14.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 3); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); adrenal gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185920,PTCH1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.1084% (minimum 99%, Missing); basal ganglia: 89.7436% (minimum 99%, Missing); cerebellum: 94.1926% (minimum 95%, Enhanced); cerebral cortex: 93.0070% (minimum 95%, Enhanced); choroid plexus: 98.2275% (minimum 99%, Missing); hippocampal formation: 89.1421% (minimum 99%, Missing); hypothalamus: 90.7231% (minimum 99%, Missing); midbrain: 87.9630% (minimum 99%, Missing); pituitary gland: 95.9596% (minimum 99%, Missing); retina: 97.3646% (minimum 99%, Missing); spinal cord: 88.3134% (minimum 99%, Missing)",0.0381129,0.0225373,-0.11037,0,2,partial,9.1,1.5,2.5,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185955,SPACDR,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338113,0.292537,0.12963,0,2,partial,9.1,1.5,2.5,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185955,SPACDR,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338113,0.292537,0.12963,0,2,partial,9.1,1.5,2.5,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185955,SPACDR,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338113,0.292537,0.12963,0,2,partial,9.1,1.5,2.5,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185955,SPACDR,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.313768,0.277941,0.12963,0,2,partial,9.1,1.5,2.5,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185955,SPACDR,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8723% (minimum 99%, Missing); amygdala: 97.1831% (minimum 99%, Missing); basal ganglia: 94.5205% (minimum 99%, Missing); bone marrow: 96.5035% (minimum 99%, Missing); cerebellum: 94.5205% (minimum 99%, Missing); cerebral cortex: 97.1831% (minimum 99%, Missing); heart muscle: 97.1831% (minimum 99%, Missing); hippocampal formation: 96.5035% (minimum 99%, Missing); hypothalamus: 97.1831% (minimum 99%, Missing); kidney: 95.8333% (minimum 99%, Missing); liver: 97.8723% (minimum 99%, Missing); midbrain: 97.8723% (minimum 99%, Missing); pancreas: 97.8723% (minimum 99%, Missing); pituitary gland: 93.8776% (minimum 99%, Missing); retina: 95.1724% (minimum 99%, Missing); skeletal muscle: 92.6174% (minimum 99%, Missing); small intestine: 98.5714% (minimum 99%, Missing); spinal cord: 98.5714% (minimum 99%, Missing)",0.0287234,0.0157143,-0.0638255,0,80,unavailable,1.1,0.2,0.3,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185958,FAM186A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328723,0.285714,0.176174,0,80,unavailable,1.1,0.2,0.3,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185958,FAM186A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328723,0.285714,0.176174,0,80,unavailable,1.1,0.2,0.3,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185958,FAM186A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328723,0.285714,0.176174,0,80,unavailable,1.1,0.2,0.3,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185958,FAM186A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328723,0.285714,0.176174,0,80,unavailable,1.1,0.2,0.3,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185958,FAM186A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.2409% (minimum 99%, Missing); smooth muscle: 97.5806% (minimum 99%, Missing)",0.0445205,0.0245205,-0.0141935,0,80,unavailable,1.8,0.4,0.4,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix; gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185972,CCIN,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344521,0.294521,0.225806,0,80,unavailable,1.8,0.4,0.4,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix; gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185972,CCIN,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344521,0.294521,0.225806,0,80,unavailable,1.8,0.4,0.4,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix; gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185972,CCIN,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344521,0.294521,0.225806,0,80,unavailable,1.8,0.4,0.4,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix; gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185972,CCIN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344521,0.294521,0.225806,0,80,unavailable,1.8,0.4,0.4,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix; gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000185972,CCIN,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000185982,DEFB128,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000185982,DEFB128,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000185982,DEFB128,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000185982,DEFB128,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000185982,DEFB128,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 93.7063% (minimum 99%, Missing); duodenum: 98.8930% (minimum 99%, Missing); hypothalamus: 98.7109% (minimum 99%, Missing); kidney: 98.1685% (minimum 99%, Missing); retina: 97.6321% (minimum 99%, Missing); salivary gland: 96.7509% (minimum 97%, Missing)",0.0407579,-0.00249097,-0.0529371,0,80,unavailable,3.6,1.8,0.5,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186007,LEMD1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340758,0.267509,0.187063,0,80,unavailable,3.6,1.8,0.5,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186007,LEMD1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340758,0.267509,0.187063,0,80,unavailable,3.6,1.8,0.5,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186007,LEMD1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340758,0.267509,0.187063,0,80,unavailable,3.6,1.8,0.5,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186007,LEMD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340758,0.267509,0.187063,0,80,unavailable,3.6,1.8,0.5,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186007,LEMD1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.8462% (minimum 95%, Missing); adrenal gland: 46.6667% (minimum 99%, Missing); amygdala: 63.6364% (minimum 99%, Missing); basal ganglia: 58.3333% (minimum 99%, Missing); bone marrow: 66.6667% (minimum 99%, Missing); cerebellum: 41.1765% (minimum 99%, Missing); cerebral cortex: 58.3333% (minimum 99%, Missing); choroid plexus: 56.0000% (minimum 99%, Missing); colon: 53.8462% (minimum 97%, Missing); duodenum: 53.8462% (minimum 99%, Missing); esophagus: 60.8696% (minimum 97%, Missing); heart muscle: 51.8519% (minimum 99%, Missing); hippocampal formation: 58.3333% (minimum 99%, Missing); hypothalamus: 58.3333% (minimum 99%, Missing); kidney: 53.8462% (minimum 99%, Missing); liver: 58.3333% (minimum 99%, Missing); lung: 56.0000% (minimum 99%, Missing); lymph node: 46.6667% (minimum 97%, Missing); midbrain: 58.3333% (minimum 99%, Missing); pancreas: 56.0000% (minimum 99%, Missing); parathyroid gland: 58.3333% (minimum 97%, Missing); pituitary gland: 48.2759% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 38.8889% (minimum 99%, Missing); salivary gland: 51.8519% (minimum 97%, Missing); skeletal muscle: 46.6667% (minimum 99%, Missing); skin: 33.3333% (minimum 95%, Missing); small intestine: 50.0000% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 58.3333% (minimum 99%, Missing); spleen: 40.0000% (minimum 95%, Missing); stomach: 56.0000% (minimum 97%, Missing); thymus: 46.6667% (minimum 95%, Missing); thyroid gland: 48.2759% (minimum 95%, Missing); tongue: 73.6842% (minimum 97%, Missing); urinary bladder: 56.0000% (minimum 97%, Missing)",-0.616667,-0.503333,-0.601111,0,80,unavailable,2.2,1.6,2.8,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186026,ZNF284,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.8462% (minimum 65%, Missing); adrenal gland: 46.6667% (minimum 75%, Missing); amygdala: 63.6364% (minimum 75%, Missing); basal ganglia: 58.3333% (minimum 75%, Missing); bone marrow: 66.6667% (minimum 75%, Missing); cerebellum: 41.1765% (minimum 75%, Missing); cerebral cortex: 58.3333% (minimum 75%, Missing); choroid plexus: 56.0000% (minimum 75%, Missing); colon: 53.8462% (minimum 70%, Missing); duodenum: 53.8462% (minimum 75%, Missing); esophagus: 60.8696% (minimum 70%, Missing); heart muscle: 51.8519% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); kidney: 53.8462% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lung: 56.0000% (minimum 75%, Missing); lymph node: 46.6667% (minimum 70%, Missing); midbrain: 58.3333% (minimum 75%, Missing); pancreas: 56.0000% (minimum 75%, Missing); parathyroid gland: 58.3333% (minimum 70%, Missing); pituitary gland: 48.2759% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 38.8889% (minimum 75%, Missing); salivary gland: 51.8519% (minimum 70%, Missing); skeletal muscle: 46.6667% (minimum 75%, Missing); skin: 33.3333% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 58.3333% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing); stomach: 56.0000% (minimum 70%, Missing); thymus: 46.6667% (minimum 65%, Missing); thyroid gland: 48.2759% (minimum 65%, Missing); urinary bladder: 56.0000% (minimum 70%, Missing)",-0.316667,-0.233333,-0.361111,0,80,unavailable,2.2,1.6,2.8,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186026,ZNF284,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.8462% (minimum 65%, Missing); adrenal gland: 46.6667% (minimum 75%, Missing); amygdala: 63.6364% (minimum 75%, Missing); basal ganglia: 58.3333% (minimum 75%, Missing); bone marrow: 66.6667% (minimum 75%, Missing); cerebellum: 41.1765% (minimum 75%, Missing); cerebral cortex: 58.3333% (minimum 75%, Missing); choroid plexus: 56.0000% (minimum 75%, Missing); colon: 53.8462% (minimum 70%, Missing); duodenum: 53.8462% (minimum 75%, Missing); esophagus: 60.8696% (minimum 70%, Missing); heart muscle: 51.8519% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); kidney: 53.8462% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lung: 56.0000% (minimum 75%, Missing); lymph node: 46.6667% (minimum 70%, Missing); midbrain: 58.3333% (minimum 75%, Missing); pancreas: 56.0000% (minimum 75%, Missing); parathyroid gland: 58.3333% (minimum 70%, Missing); pituitary gland: 48.2759% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 38.8889% (minimum 75%, Missing); salivary gland: 51.8519% (minimum 70%, Missing); skeletal muscle: 46.6667% (minimum 75%, Missing); skin: 33.3333% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 58.3333% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing); stomach: 56.0000% (minimum 70%, Missing); thymus: 46.6667% (minimum 65%, Missing); thyroid gland: 48.2759% (minimum 65%, Missing); urinary bladder: 56.0000% (minimum 70%, Missing)",-0.316667,-0.233333,-0.361111,0,80,unavailable,2.2,1.6,2.8,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186026,ZNF284,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.8462% (minimum 65%, Missing); adrenal gland: 46.6667% (minimum 75%, Missing); amygdala: 63.6364% (minimum 75%, Missing); basal ganglia: 58.3333% (minimum 75%, Missing); bone marrow: 66.6667% (minimum 75%, Missing); cerebellum: 41.1765% (minimum 75%, Missing); cerebral cortex: 58.3333% (minimum 75%, Missing); choroid plexus: 56.0000% (minimum 75%, Missing); colon: 53.8462% (minimum 70%, Missing); duodenum: 53.8462% (minimum 75%, Missing); esophagus: 60.8696% (minimum 70%, Missing); heart muscle: 51.8519% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); kidney: 53.8462% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lung: 56.0000% (minimum 75%, Missing); lymph node: 46.6667% (minimum 70%, Missing); midbrain: 58.3333% (minimum 75%, Missing); pancreas: 56.0000% (minimum 75%, Missing); parathyroid gland: 58.3333% (minimum 70%, Missing); pituitary gland: 48.2759% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 38.8889% (minimum 75%, Missing); salivary gland: 51.8519% (minimum 70%, Missing); skeletal muscle: 46.6667% (minimum 75%, Missing); skin: 33.3333% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 58.3333% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing); stomach: 56.0000% (minimum 70%, Missing); thymus: 46.6667% (minimum 65%, Missing); thyroid gland: 48.2759% (minimum 65%, Missing); urinary bladder: 56.0000% (minimum 70%, Missing)",-0.316667,-0.233333,-0.361111,0,80,unavailable,2.2,1.6,2.8,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186026,ZNF284,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.8462% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 46.6667% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.6364% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.3333% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 41.1765% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.3333% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 56.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 53.8462% (minimum 70%, Baseline (adaptation disabled)); duodenum: 53.8462% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.8696% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 51.8519% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.3333% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.8462% (minimum 75%, Baseline (adaptation disabled)); liver: 58.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 56.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 46.6667% (minimum 70%, Baseline (adaptation disabled)); midbrain: 58.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.0000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.3333% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 48.2759% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 38.8889% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.8519% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 46.6667% (minimum 75%, Baseline (adaptation disabled)); skin: 33.3333% (minimum 65%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 58.3333% (minimum 75%, Baseline (adaptation disabled)); spleen: 40.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.6667% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 48.2759% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 56.0000% (minimum 70%, Baseline (adaptation disabled))",-0.316667,-0.233333,-0.361111,0,80,unavailable,2.2,1.6,2.8,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186026,ZNF284,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0489201,0.0289201,0.00462366,0,1,partial,0.5,0.7,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186075,ZPBP2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34892,0.29892,0.244624,0,1,partial,0.5,0.7,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186075,ZPBP2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34892,0.29892,0.244624,0,1,partial,0.5,0.7,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186075,ZPBP2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34892,0.29892,0.244624,0,1,partial,0.5,0.7,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186075,ZPBP2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347843,0.292489,0.244624,0,1,partial,0.5,0.7,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186075,ZPBP2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 89.6552% (minimum 99%, Missing); duodenum: 92.8571% (minimum 99%, Missing); liver: 49.0566% (minimum 99%, Missing); pituitary gland: 83.8710% (minimum 99%, Missing); rectum: 89.6552% (minimum 97%, Missing); small intestine: 76.4706% (minimum 99%, Missing)",0.05,-0.0734483,-0.499434,0,80,unavailable,2.7,0.3,0,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186086,NBPF6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 49.0566% (minimum 75%, Missing)",0.35,0.196552,-0.259434,0,80,unavailable,2.7,0.3,0,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186086,NBPF6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 49.0566% (minimum 75%, Missing)",0.35,0.196552,-0.259434,0,80,unavailable,2.7,0.3,0,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186086,NBPF6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 49.0566% (minimum 75%, Missing)",0.35,0.196552,-0.259434,0,80,unavailable,2.7,0.3,0,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186086,NBPF6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 49.0566% (minimum 75%, Baseline (adaptation disabled))",0.35,0.196552,-0.259434,0,80,unavailable,2.7,0.3,0,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186086,NBPF6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); bone marrow: 23.0769% (minimum 99%, Missing); cerebral cortex: 60.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 60.0000% (minimum 99%, Missing); esophagus: 60.0000% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); pancreas: 50.0000% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 37.5000% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing); skeletal muscle: 42.8571% (minimum 99%, Missing); skin: 30.0000% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 42.8571% (minimum 97%, Missing); thyroid gland: 60.0000% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.65,-0.541429,-0.759231,0,80,unavailable,1,0.4,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186103,ARGFX,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); bone marrow: 23.0769% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 60.0000% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 50.0000% (minimum 75%, Missing); retina: 37.5000% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 42.8571% (minimum 75%, Missing); skin: 30.0000% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thyroid gland: 60.0000% (minimum 65%, Missing)",-0.35,-0.271429,-0.519231,0,80,unavailable,1,0.4,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186103,ARGFX,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); bone marrow: 23.0769% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 60.0000% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 50.0000% (minimum 75%, Missing); retina: 37.5000% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 42.8571% (minimum 75%, Missing); skin: 30.0000% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thyroid gland: 60.0000% (minimum 65%, Missing)",-0.35,-0.271429,-0.519231,0,80,unavailable,1,0.4,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186103,ARGFX,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); bone marrow: 23.0769% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 60.0000% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 50.0000% (minimum 75%, Missing); retina: 37.5000% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 42.8571% (minimum 75%, Missing); skin: 30.0000% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thyroid gland: 60.0000% (minimum 65%, Missing)",-0.35,-0.271429,-0.519231,0,80,unavailable,1,0.4,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186103,ARGFX,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 23.0769% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 60.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.0000% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 50.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 37.5000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 42.8571% (minimum 75%, Baseline (adaptation disabled)); skin: 30.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 42.8571% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 60.0000% (minimum 65%, Baseline (adaptation disabled))",-0.35,-0.271429,-0.519231,0,80,unavailable,1,0.4,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186103,ARGFX,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0492066,0.0284144,0.00788695,0,80,unavailable,0.8,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186118,TEX38,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349207,0.298414,0.247887,0,80,unavailable,0.8,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186118,TEX38,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349207,0.298414,0.247887,0,80,unavailable,0.8,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186118,TEX38,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349207,0.298414,0.247887,0,80,unavailable,0.8,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186118,TEX38,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349207,0.298414,0.247887,0,80,unavailable,0.8,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186118,TEX38,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186143,PRR30,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186143,PRR30,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186143,PRR30,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186143,PRR30,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186143,PRR30,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 96.9582% (minimum 99%, Missing); pituitary gland: 98.9331% (minimum 99%, Missing)",0.05,0.023184,-0.0204183,0,1,partial,3.2,0.7,0.3,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186150,UBL4B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293184,0.219582,0,1,partial,3.2,0.7,0.3,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186150,UBL4B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293184,0.219582,0,1,partial,3.2,0.7,0.3,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186150,UBL4B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293184,0.219582,0,1,partial,3.2,0.7,0.3,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186150,UBL4B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347067,0.293184,0.219582,0,1,partial,3.2,0.7,0.3,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186150,UBL4B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 80.0000% (minimum 99%, Missing); pituitary gland: 44.4444% (minimum 99%, Missing); salivary gland: 44.4444% (minimum 97%, Missing); thymus: 80.0000% (minimum 95%, Missing)",-0.15,-0.525556,-0.545556,0,80,unavailable,0.5,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186190,BPIFB3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 44.4444% (minimum 75%, Missing); salivary gland: 44.4444% (minimum 70%, Missing)",0.15,-0.255556,-0.305556,0,80,unavailable,0.5,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186190,BPIFB3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 44.4444% (minimum 75%, Missing); salivary gland: 44.4444% (minimum 70%, Missing)",0.15,-0.255556,-0.305556,0,80,unavailable,0.5,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186190,BPIFB3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 44.4444% (minimum 75%, Missing); salivary gland: 44.4444% (minimum 70%, Missing)",0.15,-0.255556,-0.305556,0,80,unavailable,0.5,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186190,BPIFB3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 44.4444% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 44.4444% (minimum 70%, Baseline (adaptation disabled))",0.15,-0.255556,-0.305556,0,80,unavailable,0.5,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186190,BPIFB3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.1724% (minimum 95%, Missing); adrenal gland: 57.1429% (minimum 99%, Missing); amygdala: 66.6667% (minimum 99%, Missing); basal ganglia: 61.5385% (minimum 99%, Missing); bone marrow: 53.3333% (minimum 99%, Missing); cerebellum: 41.0256% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); choroid plexus: 76.1905% (minimum 99%, Missing); colon: 64.0000% (minimum 97%, Missing); duodenum: 53.3333% (minimum 99%, Missing); esophagus: 53.3333% (minimum 97%, Missing); heart muscle: 61.5385% (minimum 99%, Missing); hippocampal formation: 66.6667% (minimum 99%, Missing); hypothalamus: 61.5385% (minimum 99%, Missing); kidney: 61.5385% (minimum 99%, Missing); liver: 51.6129% (minimum 99%, Missing); lung: 61.5385% (minimum 99%, Missing); lymph node: 48.4848% (minimum 97%, Missing); midbrain: 69.5652% (minimum 99%, Missing); pancreas: 59.2593% (minimum 99%, Missing); parathyroid gland: 53.3333% (minimum 97%, Missing); pituitary gland: 61.5385% (minimum 99%, Missing); rectum: 64.0000% (minimum 97%, Missing); retina: 29.0909% (minimum 99%, Missing); salivary gland: 51.6129% (minimum 97%, Missing); skeletal muscle: 55.1724% (minimum 99%, Missing); skin: 43.2432% (minimum 95%, Missing); small intestine: 57.1429% (minimum 99%, Missing); smooth muscle: 59.2593% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 57.1429% (minimum 97%, Missing); thymus: 47.0588% (minimum 95%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); tongue: 80.0000% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",-0.517568,-0.485152,-0.699091,0,80,unavailable,3.9,1.7,2.1,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186230,ZNF749,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.1724% (minimum 65%, Missing); adrenal gland: 57.1429% (minimum 75%, Missing); amygdala: 66.6667% (minimum 75%, Missing); basal ganglia: 61.5385% (minimum 75%, Missing); bone marrow: 53.3333% (minimum 75%, Missing); cerebellum: 41.0256% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); colon: 64.0000% (minimum 70%, Missing); duodenum: 53.3333% (minimum 75%, Missing); esophagus: 53.3333% (minimum 70%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 66.6667% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); liver: 51.6129% (minimum 75%, Missing); lung: 61.5385% (minimum 75%, Missing); lymph node: 48.4848% (minimum 70%, Missing); midbrain: 69.5652% (minimum 75%, Missing); pancreas: 59.2593% (minimum 75%, Missing); parathyroid gland: 53.3333% (minimum 70%, Missing); pituitary gland: 61.5385% (minimum 75%, Missing); rectum: 64.0000% (minimum 70%, Missing); retina: 29.0909% (minimum 75%, Missing); salivary gland: 51.6129% (minimum 70%, Missing); skeletal muscle: 55.1724% (minimum 75%, Missing); skin: 43.2432% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); smooth muscle: 59.2593% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 57.1429% (minimum 70%, Missing); thymus: 47.0588% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.217568,-0.215152,-0.459091,0,80,unavailable,3.9,1.7,2.1,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186230,ZNF749,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.1724% (minimum 65%, Missing); adrenal gland: 57.1429% (minimum 75%, Missing); amygdala: 66.6667% (minimum 75%, Missing); basal ganglia: 61.5385% (minimum 75%, Missing); bone marrow: 53.3333% (minimum 75%, Missing); cerebellum: 41.0256% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); colon: 64.0000% (minimum 70%, Missing); duodenum: 53.3333% (minimum 75%, Missing); esophagus: 53.3333% (minimum 70%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 66.6667% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); liver: 51.6129% (minimum 75%, Missing); lung: 61.5385% (minimum 75%, Missing); lymph node: 48.4848% (minimum 70%, Missing); midbrain: 69.5652% (minimum 75%, Missing); pancreas: 59.2593% (minimum 75%, Missing); parathyroid gland: 53.3333% (minimum 70%, Missing); pituitary gland: 61.5385% (minimum 75%, Missing); rectum: 64.0000% (minimum 70%, Missing); retina: 29.0909% (minimum 75%, Missing); salivary gland: 51.6129% (minimum 70%, Missing); skeletal muscle: 55.1724% (minimum 75%, Missing); skin: 43.2432% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); smooth muscle: 59.2593% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 57.1429% (minimum 70%, Missing); thymus: 47.0588% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.217568,-0.215152,-0.459091,0,80,unavailable,3.9,1.7,2.1,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186230,ZNF749,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.1724% (minimum 65%, Missing); adrenal gland: 57.1429% (minimum 75%, Missing); amygdala: 66.6667% (minimum 75%, Missing); basal ganglia: 61.5385% (minimum 75%, Missing); bone marrow: 53.3333% (minimum 75%, Missing); cerebellum: 41.0256% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); colon: 64.0000% (minimum 70%, Missing); duodenum: 53.3333% (minimum 75%, Missing); esophagus: 53.3333% (minimum 70%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 66.6667% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); liver: 51.6129% (minimum 75%, Missing); lung: 61.5385% (minimum 75%, Missing); lymph node: 48.4848% (minimum 70%, Missing); midbrain: 69.5652% (minimum 75%, Missing); pancreas: 59.2593% (minimum 75%, Missing); parathyroid gland: 53.3333% (minimum 70%, Missing); pituitary gland: 61.5385% (minimum 75%, Missing); rectum: 64.0000% (minimum 70%, Missing); retina: 29.0909% (minimum 75%, Missing); salivary gland: 51.6129% (minimum 70%, Missing); skeletal muscle: 55.1724% (minimum 75%, Missing); skin: 43.2432% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); smooth muscle: 59.2593% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 57.1429% (minimum 70%, Missing); thymus: 47.0588% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.217568,-0.215152,-0.459091,0,80,unavailable,3.9,1.7,2.1,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186230,ZNF749,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.1724% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 57.1429% (minimum 75%, Baseline (adaptation disabled)); amygdala: 66.6667% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.5385% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 53.3333% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 41.0256% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 64.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 53.3333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.3333% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 61.5385% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 66.6667% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.5385% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.5385% (minimum 75%, Baseline (adaptation disabled)); liver: 51.6129% (minimum 75%, Baseline (adaptation disabled)); lung: 61.5385% (minimum 75%, Baseline (adaptation disabled)); lymph node: 48.4848% (minimum 70%, Baseline (adaptation disabled)); midbrain: 69.5652% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.2593% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 53.3333% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 61.5385% (minimum 75%, Baseline (adaptation disabled)); rectum: 64.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 29.0909% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.6129% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.1724% (minimum 75%, Baseline (adaptation disabled)); skin: 43.2432% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.1429% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.2593% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 57.1429% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.0588% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 70%, Baseline (adaptation disabled))",-0.217568,-0.215152,-0.459091,0,80,unavailable,3.9,1.7,2.1,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186230,ZNF749,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.4756% (minimum 99%, Missing); basal ganglia: 97.8788% (minimum 99%, Missing); cerebellum: 97.2892% (minimum 99%, Missing); cerebral cortex: 97.2892% (minimum 99%, Missing); choroid plexus: 98.1763% (minimum 99%, Missing); heart muscle: 97.2892% (minimum 98%, Approved); hippocampal formation: 98.4756% (minimum 99%, Missing); hypothalamus: 98.4756% (minimum 99%, Missing); kidney: 98.4756% (minimum 99%, Missing); midbrain: 98.7768% (minimum 99%, Missing); pituitary gland: 98.4756% (minimum 99%, Missing); retina: 94.1691% (minimum 99%, Missing); spinal cord: 98.4756% (minimum 99%, Missing)",0.0287879,0.00289157,-0.048309,0,1,partial,2,0.9,0.7,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186280,KDM4D,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.328788,0.272892,0.191691,0,1,partial,2,0.9,0.7,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186280,KDM4D,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.328788,0.272892,0.191691,0,1,partial,2,0.9,0.7,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186280,KDM4D,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.328788,0.272892,0.191691,0,1,partial,2,0.9,0.7,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186280,KDM4D,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.328788,0.272892,0.191691,0,1,partial,2,0.9,0.7,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186280,KDM4D,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 71.7949% (minimum 95%, Missing); adrenal gland: 75.6757% (minimum 99%, Missing); amygdala: 81.1594% (minimum 99%, Missing); basal ganglia: 78.8732% (minimum 99%, Missing); bone marrow: 67.4699% (minimum 99%, Missing); cerebellum: 70.0000% (minimum 99%, Missing); cerebral cortex: 73.6842% (minimum 99%, Missing); choroid plexus: 82.3529% (minimum 99%, Missing); colon: 70.0000% (minimum 97%, Missing); duodenum: 80.0000% (minimum 99%, Missing); esophagus: 63.6364% (minimum 97%, Missing); heart muscle: 65.8824% (minimum 99%, Missing); hippocampal formation: 81.1594% (minimum 99%, Missing); hypothalamus: 81.1594% (minimum 99%, Missing); kidney: 65.8824% (minimum 99%, Missing); liver: 71.7949% (minimum 99%, Missing); lung: 72.7273% (minimum 99%, Missing); lymph node: 70.8861% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 68.2927% (minimum 99%, Missing); parathyroid gland: 63.6364% (minimum 97%, Missing); pituitary gland: 75.6757% (minimum 99%, Missing); rectum: 76.7123% (minimum 97%, Missing); retina: 50.9091% (minimum 99%, Missing); salivary gland: 71.7949% (minimum 97%, Missing); skeletal muscle: 68.2927% (minimum 99%, Missing); skin: 73.6842% (minimum 95%, Missing); small intestine: 77.7778% (minimum 99%, Missing); smooth muscle: 72.7273% (minimum 99%, Missing); spinal cord: 78.8732% (minimum 99%, Missing); spleen: 67.4699% (minimum 95%, Missing); stomach: 72.7273% (minimum 97%, Missing); thymus: 70.0000% (minimum 95%, Missing); thyroid gland: 58.9474% (minimum 95%, Missing); tongue: 55.4455% (minimum 97%, Missing); urinary bladder: 68.2927% (minimum 97%, Missing)",-0.360526,-0.415545,-0.480909,0,80,unavailable,5.4,4.5,3.9,"retina: 5.4 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186300,ZNF555,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.4699% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 73.6842% (minimum 75%, Missing); esophagus: 63.6364% (minimum 70%, Missing); heart muscle: 65.8824% (minimum 75%, Missing); kidney: 65.8824% (minimum 75%, Missing); liver: 71.7949% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); pancreas: 68.2927% (minimum 75%, Missing); parathyroid gland: 63.6364% (minimum 70%, Missing); retina: 50.9091% (minimum 75%, Missing); skeletal muscle: 68.2927% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); thyroid gland: 58.9474% (minimum 65%, Missing); tongue: 55.4455% (minimum 70%, Missing); urinary bladder: 68.2927% (minimum 70%, Missing)",-0.0605263,-0.145545,-0.240909,0,80,unavailable,5.4,4.5,3.9,"retina: 5.4 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186300,ZNF555,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.4699% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 73.6842% (minimum 75%, Missing); esophagus: 63.6364% (minimum 70%, Missing); heart muscle: 65.8824% (minimum 75%, Missing); kidney: 65.8824% (minimum 75%, Missing); liver: 71.7949% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); pancreas: 68.2927% (minimum 75%, Missing); parathyroid gland: 63.6364% (minimum 70%, Missing); retina: 50.9091% (minimum 75%, Missing); skeletal muscle: 68.2927% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); thyroid gland: 58.9474% (minimum 65%, Missing); tongue: 55.4455% (minimum 70%, Missing); urinary bladder: 68.2927% (minimum 70%, Missing)",-0.0605263,-0.145545,-0.240909,0,80,unavailable,5.4,4.5,3.9,"retina: 5.4 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186300,ZNF555,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.4699% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 73.6842% (minimum 75%, Missing); esophagus: 63.6364% (minimum 70%, Missing); heart muscle: 65.8824% (minimum 75%, Missing); kidney: 65.8824% (minimum 75%, Missing); liver: 71.7949% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); pancreas: 68.2927% (minimum 75%, Missing); parathyroid gland: 63.6364% (minimum 70%, Missing); retina: 50.9091% (minimum 75%, Missing); skeletal muscle: 68.2927% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); thyroid gland: 58.9474% (minimum 65%, Missing); tongue: 55.4455% (minimum 70%, Missing); urinary bladder: 68.2927% (minimum 70%, Missing)",-0.0605263,-0.145545,-0.240909,0,80,unavailable,5.4,4.5,3.9,"retina: 5.4 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186300,ZNF555,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.4699% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.6842% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.6364% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.8824% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.8824% (minimum 75%, Baseline (adaptation disabled)); liver: 71.7949% (minimum 75%, Baseline (adaptation disabled)); lung: 72.7273% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.2927% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.6364% (minimum 70%, Baseline (adaptation disabled)); retina: 50.9091% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 68.2927% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.7273% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 58.9474% (minimum 65%, Baseline (adaptation disabled)); tongue: 55.4455% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 68.2927% (minimum 70%, Baseline (adaptation disabled))",-0.0605263,-0.145545,-0.240909,0,80,unavailable,5.4,4.5,3.9,"retina: 5.4 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186300,ZNF555,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 97.3333% (minimum 99%, Missing)",0.0364865,0.03,-0.0166667,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186334,SLC36A3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.336486,0.3,0.223333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186334,SLC36A3,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.336486,0.3,0.223333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186334,SLC36A3,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.336486,0.3,0.223333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186334,SLC36A3,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.336486,0.3,0.223333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186334,SLC36A3,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 83.3333% (minimum 95%, Enhanced); choroid plexus: 35.7143% (minimum 99%, Missing); skin: 8.0645% (minimum 95%, Missing)",-0.869355,0.03,-0.632857,0,6,partial,0.9,0,5.7,"skin: 5.7 nTPM (manageable, limit 5)",,69,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186393,KRT26,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 35.7143% (minimum 75%, Missing); skin: 8.0645% (minimum 65%, Missing)",-0.569355,0.3,-0.392857,0,6,partial,0.9,0,5.7,"skin: 5.7 nTPM (manageable, limit 5)",,69,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186393,KRT26,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 35.7143% (minimum 75%, Missing); skin: 8.0645% (minimum 65%, Missing)",-0.569355,0.3,-0.392857,0,6,partial,0.9,0,5.7,"skin: 5.7 nTPM (manageable, limit 5)",,69,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186393,KRT26,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 35.7143% (minimum 75%, Missing); skin: 8.0645% (minimum 65%, Missing)",-0.569355,0.3,-0.392857,0,6,partial,0.9,0,5.7,"skin: 5.7 nTPM (manageable, limit 5)",,69,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186393,KRT26,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 35.7143% (minimum 75%, Baseline (adaptation disabled)); skin: 8.0645% (minimum 65%, Baseline (adaptation disabled))",-0.569355,0.3,-0.392857,0,6,partial,0.9,0,5.7,"skin: 5.7 nTPM (manageable, limit 5)",,69,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186393,KRT26,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 95%, Missing); adrenal gland: 80.0000% (minimum 99%, Missing); amygdala: 52.6316% (minimum 99%, Missing); basal ganglia: 55.5556% (minimum 99%, Missing); bone marrow: 95.2381% (minimum 99%, Missing); cerebellum: 51.2821% (minimum 99%, Missing); cerebral cortex: 58.8235% (minimum 99%, Missing); choroid plexus: 95.2381% (minimum 99%, Missing); colon: 52.6316% (minimum 97%, Missing); duodenum: 83.3333% (minimum 99%, Missing); esophagus: 68.9655% (minimum 97%, Missing); heart muscle: 62.5000% (minimum 99%, Missing); hippocampal formation: 57.1429% (minimum 99%, Missing); hypothalamus: 60.6061% (minimum 99%, Missing); kidney: 58.8235% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 68.9655% (minimum 99%, Missing); lymph node: 71.4286% (minimum 97%, Missing); midbrain: 55.5556% (minimum 99%, Missing); pancreas: 58.8235% (minimum 99%, Missing); parathyroid gland: 80.0000% (minimum 97%, Missing); pituitary gland: 74.0741% (minimum 99%, Missing); rectum: 74.0741% (minimum 97%, Missing); retina: 51.2821% (minimum 99%, Missing); salivary gland: 64.5161% (minimum 97%, Missing); skeletal muscle: 62.5000% (minimum 99%, Missing); skin: 64.5161% (minimum 95%, Missing); small intestine: 68.9655% (minimum 99%, Missing); smooth muscle: 60.6061% (minimum 99%, Missing); spinal cord: 54.0541% (minimum 99%, Missing); spleen: 64.5161% (minimum 95%, Missing); stomach: 64.5161% (minimum 97%, Missing); thymus: 71.4286% (minimum 95%, Missing); thyroid gland: 60.6061% (minimum 95%, Missing); tongue: 64.5161% (minimum 97%, Missing); urinary bladder: 55.5556% (minimum 97%, Missing)",-0.394444,-0.443684,-0.477179,0,80,unavailable,1.9,1.8,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186446,ZNF501,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 65%, Missing); amygdala: 52.6316% (minimum 75%, Missing); basal ganglia: 55.5556% (minimum 75%, Missing); cerebellum: 51.2821% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); colon: 52.6316% (minimum 70%, Missing); esophagus: 68.9655% (minimum 70%, Missing); heart muscle: 62.5000% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 60.6061% (minimum 75%, Missing); kidney: 58.8235% (minimum 75%, Missing); lung: 68.9655% (minimum 75%, Missing); midbrain: 55.5556% (minimum 75%, Missing); pancreas: 58.8235% (minimum 75%, Missing); pituitary gland: 74.0741% (minimum 75%, Missing); retina: 51.2821% (minimum 75%, Missing); salivary gland: 64.5161% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); skin: 64.5161% (minimum 65%, Missing); small intestine: 68.9655% (minimum 75%, Missing); smooth muscle: 60.6061% (minimum 75%, Missing); spinal cord: 54.0541% (minimum 75%, Missing); spleen: 64.5161% (minimum 65%, Missing); stomach: 64.5161% (minimum 70%, Missing); thyroid gland: 60.6061% (minimum 65%, Missing); tongue: 64.5161% (minimum 70%, Missing); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.0944444,-0.173684,-0.237179,0,80,unavailable,1.9,1.8,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186446,ZNF501,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 65%, Missing); amygdala: 52.6316% (minimum 75%, Missing); basal ganglia: 55.5556% (minimum 75%, Missing); cerebellum: 51.2821% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); colon: 52.6316% (minimum 70%, Missing); esophagus: 68.9655% (minimum 70%, Missing); heart muscle: 62.5000% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 60.6061% (minimum 75%, Missing); kidney: 58.8235% (minimum 75%, Missing); lung: 68.9655% (minimum 75%, Missing); midbrain: 55.5556% (minimum 75%, Missing); pancreas: 58.8235% (minimum 75%, Missing); pituitary gland: 74.0741% (minimum 75%, Missing); retina: 51.2821% (minimum 75%, Missing); salivary gland: 64.5161% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); skin: 64.5161% (minimum 65%, Missing); small intestine: 68.9655% (minimum 75%, Missing); smooth muscle: 60.6061% (minimum 75%, Missing); spinal cord: 54.0541% (minimum 75%, Missing); spleen: 64.5161% (minimum 65%, Missing); stomach: 64.5161% (minimum 70%, Missing); thyroid gland: 60.6061% (minimum 65%, Missing); tongue: 64.5161% (minimum 70%, Missing); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.0944444,-0.173684,-0.237179,0,80,unavailable,1.9,1.8,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186446,ZNF501,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 65%, Missing); amygdala: 52.6316% (minimum 75%, Missing); basal ganglia: 55.5556% (minimum 75%, Missing); cerebellum: 51.2821% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); colon: 52.6316% (minimum 70%, Missing); esophagus: 68.9655% (minimum 70%, Missing); heart muscle: 62.5000% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 60.6061% (minimum 75%, Missing); kidney: 58.8235% (minimum 75%, Missing); lung: 68.9655% (minimum 75%, Missing); midbrain: 55.5556% (minimum 75%, Missing); pancreas: 58.8235% (minimum 75%, Missing); pituitary gland: 74.0741% (minimum 75%, Missing); retina: 51.2821% (minimum 75%, Missing); salivary gland: 64.5161% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); skin: 64.5161% (minimum 65%, Missing); small intestine: 68.9655% (minimum 75%, Missing); smooth muscle: 60.6061% (minimum 75%, Missing); spinal cord: 54.0541% (minimum 75%, Missing); spleen: 64.5161% (minimum 65%, Missing); stomach: 64.5161% (minimum 70%, Missing); thyroid gland: 60.6061% (minimum 65%, Missing); tongue: 64.5161% (minimum 70%, Missing); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.0944444,-0.173684,-0.237179,0,80,unavailable,1.9,1.8,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186446,ZNF501,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 65%, Baseline (adaptation disabled)); amygdala: 52.6316% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.5556% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 51.2821% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.8235% (minimum 75%, Baseline (adaptation disabled)); colon: 52.6316% (minimum 70%, Baseline (adaptation disabled)); esophagus: 68.9655% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.1429% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.6061% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.8235% (minimum 75%, Baseline (adaptation disabled)); lung: 68.9655% (minimum 75%, Baseline (adaptation disabled)); midbrain: 55.5556% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.8235% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 74.0741% (minimum 75%, Baseline (adaptation disabled)); retina: 51.2821% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.5161% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); skin: 64.5161% (minimum 65%, Baseline (adaptation disabled)); small intestine: 68.9655% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.6061% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 54.0541% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.5161% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.5161% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 60.6061% (minimum 65%, Baseline (adaptation disabled)); tongue: 64.5161% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 55.5556% (minimum 70%, Baseline (adaptation disabled))",-0.0944444,-0.173684,-0.237179,0,80,unavailable,1.9,1.8,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186446,ZNF501,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0.3,0.3,0,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186451,SPATA12,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.3,0.3,0,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186451,SPATA12,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.3,0.3,0,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186451,SPATA12,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.3,0.3,0,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186451,SPATA12,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.285149,0.235149,0,3,partial,0.3,0.3,0,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186451,SPATA12,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0452607,0.03,0.000566038,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186452,TMPRSS12,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345261,0.3,0.240566,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186452,TMPRSS12,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345261,0.3,0.240566,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186452,TMPRSS12,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345261,0.3,0.240566,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186452,TMPRSS12,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345261,0.3,0.240566,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186452,TMPRSS12,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7222% (minimum 95%, Missing); adrenal gland: 97.7077% (minimum 99%, Missing); amygdala: 95.7865% (minimum 99%, Missing); basal ganglia: 96.6006% (minimum 99%, Missing); cerebellum: 97.7077% (minimum 99%, Missing); cerebral cortex: 95.2514% (minimum 99%, Missing); heart muscle: 95.5182% (minimum 99%, Missing); hippocampal formation: 96.6006% (minimum 99%, Missing); hypothalamus: 96.0563% (minimum 99%, Missing); kidney: 97.9885% (minimum 99%, Missing); lung: 97.7077% (minimum 99%, Missing); midbrain: 96.6006% (minimum 99%, Missing); pituitary gland: 98.8406% (minimum 99%, Missing); retina: 97.9885% (minimum 99%, Missing); skeletal muscle: 98.5549% (minimum 99%, Missing); small intestine: 98.8406% (minimum 99%, Missing); smooth muscle: 98.8406% (minimum 99%, Missing); spinal cord: 97.1510% (minimum 99%, Missing)",-0.00277778,0.00428571,-0.037486,0,80,unavailable,1.7,0.9,1.9,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186453,FAM228A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297222,0.274286,0.202514,0,80,unavailable,1.7,0.9,1.9,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186453,FAM228A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297222,0.274286,0.202514,0,80,unavailable,1.7,0.9,1.9,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186453,FAM228A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297222,0.274286,0.202514,0,80,unavailable,1.7,0.9,1.9,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186453,FAM228A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297222,0.274286,0.202514,0,80,unavailable,1.7,0.9,1.9,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186453,FAM228A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4841% (minimum 95%, Missing); adrenal gland: 85.1737% (minimum 99%, Uncertain); amygdala: 59.7185% (minimum 99%, Missing); basal ganglia: 89.4566% (minimum 99%, Missing); bone marrow: 65.8901% (minimum 99%, Uncertain); cerebellum: 95.0043% (minimum 99%, Missing); cerebral cortex: 56.9437% (minimum 99%, Missing); choroid plexus: 80.1599% (minimum 99%, Missing); colon: 82.5599% (minimum 97%, Missing); duodenum: 89.6748% (minimum 99%, Uncertain); esophagus: 90.2619% (minimum 97%, Missing); heart muscle: 90.7819% (minimum 99%, Uncertain); hippocampal formation: 71.4378% (minimum 99%, Missing); hypothalamus: 60.4053% (minimum 99%, Missing); kidney: 94.5159% (minimum 99%, Missing); liver: 91.0818% (minimum 99%, Uncertain); lung: 86.8504% (minimum 99%, Uncertain); lymph node: 73.2404% (minimum 97%, Missing); midbrain: 88.8799% (minimum 99%, Missing); pancreas: 94.4349% (minimum 99%, Missing); pituitary gland: 88.3814% (minimum 99%, Missing); rectum: 87.1937% (minimum 97%, Uncertain); retina: 89.2395% (minimum 99%, Missing); salivary gland: 94.2735% (minimum 97%, Missing); skeletal muscle: 95.7465% (minimum 99%, Uncertain); skin: 94.1126% (minimum 95%, Missing); small intestine: 85.9704% (minimum 99%, Uncertain); smooth muscle: 86.9874% (minimum 99%, Missing); spinal cord: 90.3358% (minimum 99%, Missing); spleen: 67.8352% (minimum 95%, Missing); stomach: 88.8799% (minimum 97%, Missing); thymus: 65.8507% (minimum 95%, Missing); tongue: 89.8208% (minimum 97%, Missing); urinary bladder: 84.7158% (minimum 97%, Uncertain)",-0.291493,-0.237596,-0.420563,0,4,partial,83.4,40.3,57.2,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); thymus: 57.2 nTPM (manageable, limit 5); bone marrow: 57.1 nTPM (vital, limit 1); spleen: 52.3 nTPM (manageable, limit 5); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (manageable, limit 5); lymph node: 40.3 nTPM (protected, limit 2); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 2); urinary bladder: 19.9 nTPM (protected, limit 2); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 2); pituitary gland: 14.5 nTPM (vital, limit 1); stomach: 13.8 nTPM (protected, limit 2); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 2); esophagus: 11.9 nTPM (protected, limit 2); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); skin: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 2); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186469,GNG2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 59.7185% (minimum 75%, Missing); bone marrow: 65.8901% (minimum 75%, Uncertain); cerebral cortex: 56.9437% (minimum 75%, Missing); hippocampal formation: 71.4378% (minimum 75%, Missing); hypothalamus: 60.4053% (minimum 75%, Missing)",0.00850746,0.0324037,-0.180563,0,4,partial,83.4,40.3,57.2,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); thymus: 57.2 nTPM (manageable, limit 5); bone marrow: 57.1 nTPM (vital, limit 1); spleen: 52.3 nTPM (manageable, limit 5); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (manageable, limit 5); lymph node: 40.3 nTPM (protected, limit 2); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 2); urinary bladder: 19.9 nTPM (protected, limit 2); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 2); pituitary gland: 14.5 nTPM (vital, limit 1); stomach: 13.8 nTPM (protected, limit 2); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 2); esophagus: 11.9 nTPM (protected, limit 2); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); skin: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 2); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186469,GNG2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 59.7185% (minimum 75%, Missing); bone marrow: 65.8901% (minimum 75%, Uncertain); cerebral cortex: 56.9437% (minimum 75%, Missing); hippocampal formation: 71.4378% (minimum 75%, Missing); hypothalamus: 60.4053% (minimum 75%, Missing)",0.00850746,0.0324037,-0.180563,0,4,partial,83.4,40.3,57.2,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); thymus: 57.2 nTPM (manageable, limit 5); bone marrow: 57.1 nTPM (vital, limit 1); spleen: 52.3 nTPM (manageable, limit 5); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (manageable, limit 5); lymph node: 40.3 nTPM (protected, limit 3); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 3); urinary bladder: 19.9 nTPM (protected, limit 3); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 3); pituitary gland: 14.5 nTPM (vital, limit 1); stomach: 13.8 nTPM (protected, limit 3); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 3); esophagus: 11.9 nTPM (protected, limit 3); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); skin: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 3); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186469,GNG2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 59.7185% (minimum 75%, Missing); bone marrow: 65.8901% (minimum 75%, Uncertain); cerebral cortex: 56.9437% (minimum 75%, Missing); hippocampal formation: 71.4378% (minimum 75%, Missing); hypothalamus: 60.4053% (minimum 75%, Missing)",0.00850746,0.0324037,-0.180563,0,4,partial,83.4,40.3,57.2,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); thymus: 57.2 nTPM (manageable, limit 5); bone marrow: 57.1 nTPM (vital, limit 1); spleen: 52.3 nTPM (manageable, limit 5); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (manageable, limit 5); lymph node: 40.3 nTPM (protected, limit 3); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 3); urinary bladder: 19.9 nTPM (protected, limit 3); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 3); pituitary gland: 14.5 nTPM (vital, limit 1); stomach: 13.8 nTPM (protected, limit 3); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 3); esophagus: 11.9 nTPM (protected, limit 3); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); skin: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 3); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186469,GNG2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 59.7185% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 65.8901% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.9437% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.4378% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.4053% (minimum 75%, Baseline (adaptation disabled))",0.00850746,0.0324037,-0.180563,0,4,partial,83.4,40.3,57.2,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); thymus: 57.2 nTPM (manageable, limit 5); bone marrow: 57.1 nTPM (vital, limit 1); spleen: 52.3 nTPM (manageable, limit 5); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (manageable, limit 5); lymph node: 40.3 nTPM (protected, limit 3); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 3); urinary bladder: 19.9 nTPM (protected, limit 3); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 3); pituitary gland: 14.5 nTPM (vital, limit 1); stomach: 13.8 nTPM (protected, limit 3); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 3); esophagus: 11.9 nTPM (protected, limit 3); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); skin: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 3); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186469,GNG2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.0992% (minimum 99%, Missing); basal ganglia: 98.0746% (minimum 99%, Missing); choroid plexus: 52.0434% (minimum 99%, Missing); hippocampal formation: 97.2554% (minimum 99%, Missing); hypothalamus: 94.5476% (minimum 99%, Missing); lung: 96.3357% (minimum 99%, Missing); midbrain: 98.5490% (minimum 99%, Missing); retina: 98.6683% (minimum 99%, Missing)",0.05,0.03,-0.469566,0,5,partial,75.1,0.1,0,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),66,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186471,AKAP14,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 52.0434% (minimum 75%, Missing)",0.35,0.3,-0.229566,0,5,partial,75.1,0.1,0,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),66,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186471,AKAP14,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 52.0434% (minimum 75%, Missing)",0.35,0.3,-0.229566,0,5,partial,75.1,0.1,0,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),66,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186471,AKAP14,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 52.0434% (minimum 75%, Missing)",0.35,0.3,-0.229566,0,5,partial,75.1,0.1,0,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),66,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186471,AKAP14,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 52.0434% (minimum 75%, Baseline (adaptation disabled))",0.35,0.298775,-0.229566,0,5,partial,75.1,0.1,0,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),66,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186471,AKAP14,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 81.8182% (minimum 99%, Missing); amygdala: 23.6842% (minimum 99%, Missing); basal ganglia: 15.8358% (minimum 99%, Missing); bone marrow: 98.1818% (minimum 99%, Missing); cerebellum: 12.9808% (minimum 99%, Missing); cerebral cortex: 12.0536% (minimum 99%, Missing); choroid plexus: 96.4286% (minimum 99%, Missing); colon: 94.7368% (minimum 97%, Missing); duodenum: 98.1818% (minimum 99%, Missing); hippocampal formation: 18.7500% (minimum 99%, Missing); hypothalamus: 22.5941% (minimum 99%, Missing); liver: 96.4286% (minimum 99%, Missing); lung: 98.1818% (minimum 99%, Missing); midbrain: 42.5197% (minimum 99%, Missing); pancreas: 91.5254% (minimum 99%, Missing); pituitary gland: 27.2727% (minimum 99%, Missing); retina: 54.0000% (minimum 99%, Missing); skeletal muscle: 98.1818% (minimum 99%, Missing); skin: 94.7368% (minimum 95%, Missing); small intestine: 96.4286% (minimum 99%, Missing); spinal cord: 64.2857% (minimum 99%, Missing); stomach: 94.7368% (minimum 97%, Missing)",-0.00263158,-0.0226316,-0.869464,0,80,unavailable,39.4,0.3,0.3,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186487,MYT1L,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 23.6842% (minimum 75%, Missing); basal ganglia: 15.8358% (minimum 75%, Missing); cerebellum: 12.9808% (minimum 75%, Missing); cerebral cortex: 12.0536% (minimum 75%, Missing); hippocampal formation: 18.7500% (minimum 75%, Missing); hypothalamus: 22.5941% (minimum 75%, Missing); midbrain: 42.5197% (minimum 75%, Missing); pituitary gland: 27.2727% (minimum 75%, Missing); retina: 54.0000% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing)",0.297368,0.247368,-0.629464,0,80,unavailable,39.4,0.3,0.3,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186487,MYT1L,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 23.6842% (minimum 75%, Missing); basal ganglia: 15.8358% (minimum 75%, Missing); cerebellum: 12.9808% (minimum 75%, Missing); cerebral cortex: 12.0536% (minimum 75%, Missing); hippocampal formation: 18.7500% (minimum 75%, Missing); hypothalamus: 22.5941% (minimum 75%, Missing); midbrain: 42.5197% (minimum 75%, Missing); pituitary gland: 27.2727% (minimum 75%, Missing); retina: 54.0000% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing)",0.297368,0.247368,-0.629464,0,80,unavailable,39.4,0.3,0.3,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186487,MYT1L,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 23.6842% (minimum 75%, Missing); basal ganglia: 15.8358% (minimum 75%, Missing); cerebellum: 12.9808% (minimum 75%, Missing); cerebral cortex: 12.0536% (minimum 75%, Missing); hippocampal formation: 18.7500% (minimum 75%, Missing); hypothalamus: 22.5941% (minimum 75%, Missing); midbrain: 42.5197% (minimum 75%, Missing); pituitary gland: 27.2727% (minimum 75%, Missing); retina: 54.0000% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing)",0.297368,0.247368,-0.629464,0,80,unavailable,39.4,0.3,0.3,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186487,MYT1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 23.6842% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 15.8358% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 12.9808% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 12.0536% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 18.7500% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 22.5941% (minimum 75%, Baseline (adaptation disabled)); midbrain: 42.5197% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 27.2727% (minimum 75%, Baseline (adaptation disabled)); retina: 54.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.2857% (minimum 75%, Baseline (adaptation disabled))",0.297368,0.247368,-0.629464,0,80,unavailable,39.4,0.3,0.3,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186487,MYT1L,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186513,OR9Q2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186513,OR9Q2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186513,OR9Q2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186513,OR9Q2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186513,OR9Q2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0496683,0.0297512,0.00950257,0,80,unavailable,0.6,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186562,DEFB105A,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.349668,0.299751,0.249503,0,80,unavailable,0.6,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186562,DEFB105A,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.349668,0.299751,0.249503,0,80,unavailable,0.6,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186562,DEFB105A,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.349668,0.299751,0.249503,0,80,unavailable,0.6,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186562,DEFB105A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.349668,0.299751,0.249503,0,80,unavailable,0.6,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186562,DEFB105A,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186572,DEFB107A,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186572,DEFB107A,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186572,DEFB107A,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186572,DEFB107A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186572,DEFB107A,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,0,routine_complete,0,0.1,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186579,DEFB106A,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0.1,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186579,DEFB106A,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0.1,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186579,DEFB106A,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0.1,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186579,DEFB106A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.299966,0.25,0,0,routine_complete,0,0.1,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186579,DEFB106A,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 81.2918% (minimum 99%, Missing); lung: 97.8552% (minimum 99%, Missing); small intestine: 98.1183% (minimum 99%, Missing); spleen: 94.8052% (minimum 95%, Missing)",-0.00194805,0.0138275,-0.177082,0,80,unavailable,8.4,0.6,2,"bone marrow: 8.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186583,SPATC1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.298052,0.283827,0.0629176,0,80,unavailable,8.4,0.6,2,"bone marrow: 8.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186583,SPATC1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.298052,0.283827,0.0629176,0,80,unavailable,8.4,0.6,2,"bone marrow: 8.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186583,SPATC1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.298052,0.283827,0.0629176,0,80,unavailable,8.4,0.6,2,"bone marrow: 8.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186583,SPATC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.298052,0.283827,0.0629176,0,80,unavailable,8.4,0.6,2,"bone marrow: 8.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186583,SPATC1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186599,DEFB105B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186599,DEFB105B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186599,DEFB105B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186599,DEFB105B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186599,DEFB105B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.7826% (minimum 99%, Missing); amygdala: 94.7826% (minimum 99%, Missing); basal ganglia: 90.0826% (minimum 99%, Missing); bone marrow: 83.8462% (minimum 99%, Missing); cerebellum: 97.3214% (minimum 99%, Missing); cerebral cortex: 93.1624% (minimum 99%, Missing); choroid plexus: 75.6944% (minimum 99%, Missing); colon: 91.5966% (minimum 97%, Missing); duodenum: 95.6140% (minimum 99%, Missing); esophagus: 93.1624% (minimum 97%, Missing); heart muscle: 95.6140% (minimum 99%, Missing); hippocampal formation: 93.9655% (minimum 99%, Missing); hypothalamus: 93.9655% (minimum 99%, Missing); kidney: 92.3729% (minimum 99%, Missing); liver: 97.3214% (minimum 99%, Missing); lung: 94.7826% (minimum 99%, Missing); lymph node: 88.6179% (minimum 97%, Missing); midbrain: 96.4602% (minimum 99%, Missing); pancreas: 95.6140% (minimum 99%, Missing); parathyroid gland: 87.9032% (minimum 97%, Missing); pituitary gland: 91.5966% (minimum 99%, Missing); rectum: 91.5966% (minimum 97%, Missing); retina: 96.4602% (minimum 99%, Missing); skeletal muscle: 93.9655% (minimum 99%, Missing); skin: 92.3729% (minimum 95%, Missing); small intestine: 95.6140% (minimum 99%, Missing); smooth muscle: 93.9655% (minimum 99%, Missing); spinal cord: 97.3214% (minimum 99%, Missing); stomach: 94.7826% (minimum 97%, Missing); thymus: 72.1854% (minimum 95%, Missing); thyroid gland: 90.8333% (minimum 95%, Missing); tongue: 94.7826% (minimum 97%, Missing)",-0.228146,-0.0909677,-0.233056,0,80,unavailable,3.5,1.5,4.2,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186638,KIF24,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0718543,0.179032,0.00694444,0,80,unavailable,3.5,1.5,4.2,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186638,KIF24,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0718543,0.179032,0.00694444,0,80,unavailable,3.5,1.5,4.2,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186638,KIF24,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0718543,0.179032,0.00694444,0,80,unavailable,3.5,1.5,4.2,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186638,KIF24,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0718543,0.179032,0.00694444,0,80,unavailable,3.5,1.5,4.2,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186638,KIF24,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"skin: 50.0000% (minimum 80%, Supported)",-0.3,0.03,0.01,9,3,partial,0,0,0.5,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186645,SPDYE17,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"skin: 50.0000% (minimum 55%, Supported)",-0.05,0.3,0.25,9,3,partial,0,0,0.5,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186645,SPDYE17,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"skin: 50.0000% (minimum 55%, Supported)",-0.05,0.3,0.25,9,3,partial,0,0,0.5,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186645,SPDYE17,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"skin: 50.0000% (minimum 55%, Supported)",-0.05,0.3,0.25,9,3,partial,0,0,0.5,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186645,SPDYE17,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"skin: 50.0000% (minimum 65%, Baseline (adaptation disabled))",-0.15,0.3,0.25,9,3,partial,0,0,0.5,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000186645,SPDYE17,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.8718% (minimum 99%, Missing); bone marrow: 94.8718% (minimum 99%, Missing); cerebellum: 92.5000% (minimum 99%, Missing); cerebral cortex: 97.3684% (minimum 99%, Missing); choroid plexus: 97.3684% (minimum 99%, Missing); hypothalamus: 94.8718% (minimum 99%, Missing); kidney: 97.3684% (minimum 99%, Missing); liver: 90.2439% (minimum 99%, Missing); midbrain: 97.3684% (minimum 99%, Missing); retina: 94.8718% (minimum 99%, Missing); spinal cord: 97.3684% (minimum 99%, Missing); spleen: 92.5000% (minimum 95%, Missing)",-0.025,0.03,-0.087561,0,80,unavailable,0.4,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186714,CCDC73,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.275,0.3,0.152439,0,80,unavailable,0.4,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186714,CCDC73,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.275,0.3,0.152439,0,80,unavailable,0.4,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186714,CCDC73,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.275,0.3,0.152439,0,80,unavailable,0.4,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186714,CCDC73,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.275,0.3,0.152439,0,80,unavailable,0.4,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186714,CCDC73,current_fixed,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186788,SPATA31D3,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186788,SPATA31D3,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186788,SPATA31D3,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186788,SPATA31D3,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186788,SPATA31D3,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 88.8889% (minimum 99%, Missing); basal ganglia: 53.3333% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 88.8889% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); hippocampal formation: 88.8889% (minimum 99%, Missing); kidney: 80.0000% (minimum 99%, Missing)",0.05,-0.0811111,-0.456667,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186790,FOXE3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 53.3333% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing)",0.35,0.188889,-0.216667,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186790,FOXE3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 53.3333% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing)",0.35,0.188889,-0.216667,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186790,FOXE3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 53.3333% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing)",0.35,0.188889,-0.216667,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186790,FOXE3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 53.3333% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.35,0.188889,-0.216667,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186790,FOXE3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.7143% (minimum 95%, Missing); adrenal gland: 54.5455% (minimum 99%, Missing); amygdala: 59.3156% (minimum 99%, Missing); basal ganglia: 57.9926% (minimum 99%, Missing); bone marrow: 76.0976% (minimum 99%, Missing); cerebellum: 58.2090% (minimum 99%, Missing); cerebral cortex: 51.8272% (minimum 99%, Missing); choroid plexus: 58.8679% (minimum 99%, Missing); colon: 55.7143% (minimum 97%, Missing); duodenum: 60.2317% (minimum 99%, Missing); esophagus: 62.1514% (minimum 97%, Missing); heart muscle: 60.7004% (minimum 99%, Missing); hippocampal formation: 54.7368% (minimum 99%, Missing); hypothalamus: 60.9375% (minimum 99%, Missing); kidney: 58.8679% (minimum 99%, Missing); liver: 60.0000% (minimum 99%, Missing); lung: 60.7004% (minimum 99%, Missing); lymph node: 49.8403% (minimum 97%, Missing); midbrain: 54.3554% (minimum 99%, Missing); pancreas: 56.5217% (minimum 99%, Missing); parathyroid gland: 52.1739% (minimum 97%, Missing); pituitary gland: 57.1429% (minimum 99%, Missing); rectum: 53.7931% (minimum 97%, Missing); retina: 39.2947% (minimum 99%, Missing); salivary gland: 56.5217% (minimum 97%, Missing); skeletal muscle: 58.2090% (minimum 99%, Uncertain); skin: 54.1667% (minimum 95%, Missing); small intestine: 56.1151% (minimum 99%, Missing); smooth muscle: 58.6466% (minimum 99%, Missing); spinal cord: 50.9804% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 54.7368% (minimum 97%, Missing); thymus: 55.1237% (minimum 95%, Missing); thyroid gland: 50.4854% (minimum 95%, Missing); tongue: 59.5420% (minimum 97%, Missing); urinary bladder: 57.5646% (minimum 97%, Missing)",-0.45,-0.471597,-0.597053,0,2,partial,24.1,15.7,15.6,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 2); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 2); rectum: 13.4 nTPM (protected, limit 2); skin: 13.2 nTPM (manageable, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); hippocampal formation: 12.9 nTPM (vital, limit 1); thymus: 12.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.4 nTPM (protected, limit 2); small intestine: 12.2 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 2); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 2); basal ganglia: 11.3 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 2); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 2); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186812,ZNF397,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.7143% (minimum 65%, Missing); adrenal gland: 54.5455% (minimum 75%, Missing); amygdala: 59.3156% (minimum 75%, Missing); basal ganglia: 57.9926% (minimum 75%, Missing); cerebellum: 58.2090% (minimum 75%, Missing); cerebral cortex: 51.8272% (minimum 75%, Missing); choroid plexus: 58.8679% (minimum 75%, Missing); colon: 55.7143% (minimum 70%, Missing); duodenum: 60.2317% (minimum 75%, Missing); esophagus: 62.1514% (minimum 70%, Missing); heart muscle: 60.7004% (minimum 75%, Missing); hippocampal formation: 54.7368% (minimum 75%, Missing); hypothalamus: 60.9375% (minimum 75%, Missing); kidney: 58.8679% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 60.7004% (minimum 75%, Missing); lymph node: 49.8403% (minimum 70%, Missing); midbrain: 54.3554% (minimum 75%, Missing); pancreas: 56.5217% (minimum 75%, Missing); parathyroid gland: 52.1739% (minimum 70%, Missing); pituitary gland: 57.1429% (minimum 75%, Missing); rectum: 53.7931% (minimum 70%, Missing); retina: 39.2947% (minimum 75%, Missing); salivary gland: 56.5217% (minimum 70%, Missing); skeletal muscle: 58.2090% (minimum 75%, Uncertain); skin: 54.1667% (minimum 65%, Missing); small intestine: 56.1151% (minimum 75%, Missing); smooth muscle: 58.6466% (minimum 75%, Missing); spinal cord: 50.9804% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 54.7368% (minimum 70%, Missing); thymus: 55.1237% (minimum 65%, Missing); thyroid gland: 50.4854% (minimum 65%, Missing); tongue: 59.5420% (minimum 70%, Missing); urinary bladder: 57.5646% (minimum 70%, Missing)",-0.15,-0.201597,-0.357053,0,2,partial,24.1,15.7,15.6,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 2); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 2); rectum: 13.4 nTPM (protected, limit 2); skin: 13.2 nTPM (manageable, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); hippocampal formation: 12.9 nTPM (vital, limit 1); thymus: 12.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.4 nTPM (protected, limit 2); small intestine: 12.2 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 2); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 2); basal ganglia: 11.3 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 2); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 2); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186812,ZNF397,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.7143% (minimum 65%, Missing); adrenal gland: 54.5455% (minimum 75%, Missing); amygdala: 59.3156% (minimum 75%, Missing); basal ganglia: 57.9926% (minimum 75%, Missing); cerebellum: 58.2090% (minimum 75%, Missing); cerebral cortex: 51.8272% (minimum 75%, Missing); choroid plexus: 58.8679% (minimum 75%, Missing); colon: 55.7143% (minimum 70%, Missing); duodenum: 60.2317% (minimum 75%, Missing); esophagus: 62.1514% (minimum 70%, Missing); heart muscle: 60.7004% (minimum 75%, Missing); hippocampal formation: 54.7368% (minimum 75%, Missing); hypothalamus: 60.9375% (minimum 75%, Missing); kidney: 58.8679% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 60.7004% (minimum 75%, Missing); lymph node: 49.8403% (minimum 70%, Missing); midbrain: 54.3554% (minimum 75%, Missing); pancreas: 56.5217% (minimum 75%, Missing); parathyroid gland: 52.1739% (minimum 70%, Missing); pituitary gland: 57.1429% (minimum 75%, Missing); rectum: 53.7931% (minimum 70%, Missing); retina: 39.2947% (minimum 75%, Missing); salivary gland: 56.5217% (minimum 70%, Missing); skeletal muscle: 58.2090% (minimum 75%, Uncertain); skin: 54.1667% (minimum 65%, Missing); small intestine: 56.1151% (minimum 75%, Missing); smooth muscle: 58.6466% (minimum 75%, Missing); spinal cord: 50.9804% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 54.7368% (minimum 70%, Missing); thymus: 55.1237% (minimum 65%, Missing); thyroid gland: 50.4854% (minimum 65%, Missing); tongue: 59.5420% (minimum 70%, Missing); urinary bladder: 57.5646% (minimum 70%, Missing)",-0.15,-0.201597,-0.357053,0,2,partial,24.1,15.7,15.6,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 3); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 3); rectum: 13.4 nTPM (protected, limit 3); skin: 13.2 nTPM (manageable, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); hippocampal formation: 12.9 nTPM (vital, limit 1); thymus: 12.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.4 nTPM (protected, limit 3); small intestine: 12.2 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 3); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 3); basal ganglia: 11.3 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 3); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 3); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186812,ZNF397,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.7143% (minimum 65%, Missing); adrenal gland: 54.5455% (minimum 75%, Missing); amygdala: 59.3156% (minimum 75%, Missing); basal ganglia: 57.9926% (minimum 75%, Missing); cerebellum: 58.2090% (minimum 75%, Missing); cerebral cortex: 51.8272% (minimum 75%, Missing); choroid plexus: 58.8679% (minimum 75%, Missing); colon: 55.7143% (minimum 70%, Missing); duodenum: 60.2317% (minimum 75%, Missing); esophagus: 62.1514% (minimum 70%, Missing); heart muscle: 60.7004% (minimum 75%, Missing); hippocampal formation: 54.7368% (minimum 75%, Missing); hypothalamus: 60.9375% (minimum 75%, Missing); kidney: 58.8679% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 60.7004% (minimum 75%, Missing); lymph node: 49.8403% (minimum 70%, Missing); midbrain: 54.3554% (minimum 75%, Missing); pancreas: 56.5217% (minimum 75%, Missing); parathyroid gland: 52.1739% (minimum 70%, Missing); pituitary gland: 57.1429% (minimum 75%, Missing); rectum: 53.7931% (minimum 70%, Missing); retina: 39.2947% (minimum 75%, Missing); salivary gland: 56.5217% (minimum 70%, Missing); skeletal muscle: 58.2090% (minimum 75%, Uncertain); skin: 54.1667% (minimum 65%, Missing); small intestine: 56.1151% (minimum 75%, Missing); smooth muscle: 58.6466% (minimum 75%, Missing); spinal cord: 50.9804% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 54.7368% (minimum 70%, Missing); thymus: 55.1237% (minimum 65%, Missing); thyroid gland: 50.4854% (minimum 65%, Missing); tongue: 59.5420% (minimum 70%, Missing); urinary bladder: 57.5646% (minimum 70%, Missing)",-0.15,-0.201597,-0.357053,0,2,partial,24.1,15.7,15.6,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 3); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 3); rectum: 13.4 nTPM (protected, limit 3); skin: 13.2 nTPM (manageable, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); hippocampal formation: 12.9 nTPM (vital, limit 1); thymus: 12.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.4 nTPM (protected, limit 3); small intestine: 12.2 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 3); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 3); basal ganglia: 11.3 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 3); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 3); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186812,ZNF397,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.7143% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 54.5455% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.3156% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 57.9926% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 58.2090% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.8272% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.8679% (minimum 75%, Baseline (adaptation disabled)); colon: 55.7143% (minimum 70%, Baseline (adaptation disabled)); duodenum: 60.2317% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.1514% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 60.7004% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.7368% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.9375% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.8679% (minimum 75%, Baseline (adaptation disabled)); liver: 60.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 60.7004% (minimum 75%, Baseline (adaptation disabled)); lymph node: 49.8403% (minimum 70%, Baseline (adaptation disabled)); midbrain: 54.3554% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.5217% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.1739% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 57.1429% (minimum 75%, Baseline (adaptation disabled)); rectum: 53.7931% (minimum 70%, Baseline (adaptation disabled)); retina: 39.2947% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.5217% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 58.2090% (minimum 75%, Baseline (adaptation disabled)); skin: 54.1667% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.1151% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.6466% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.9804% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.7368% (minimum 70%, Baseline (adaptation disabled)); thymus: 55.1237% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.4854% (minimum 65%, Baseline (adaptation disabled)); tongue: 59.5420% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.5646% (minimum 70%, Baseline (adaptation disabled))",-0.15,-0.201597,-0.357053,0,2,partial,24.1,15.7,15.6,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 3); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 3); rectum: 13.4 nTPM (protected, limit 3); skin: 13.2 nTPM (manageable, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); hippocampal formation: 12.9 nTPM (vital, limit 1); thymus: 12.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.4 nTPM (protected, limit 3); small intestine: 12.2 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 3); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 3); basal ganglia: 11.3 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 3); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 3); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186812,ZNF397,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Missing); adrenal gland: 87.5000% (minimum 99%, Missing); bone marrow: 17.9487% (minimum 99%, Missing); cerebellum: 77.7778% (minimum 98%, Approved); cerebral cortex: 87.5000% (minimum 99%, Missing); colon: 43.7500% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 38.8889% (minimum 97%, Missing); heart muscle: 87.5000% (minimum 99%, Missing); kidney: 87.5000% (minimum 99%, Missing); liver: 87.5000% (minimum 98%, Approved); lung: 87.5000% (minimum 99%, Missing); lymph node: 23.3333% (minimum 97%, Missing); pancreas: 87.5000% (minimum 99%, Missing); pituitary gland: 87.5000% (minimum 99%, Missing); rectum: 38.8889% (minimum 97%, Missing); retina: 63.6364% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 87.5000% (minimum 99%, Missing); skin: 53.8462% (minimum 95%, Missing); small intestine: 53.8462% (minimum 99%, Missing); smooth muscle: 70.0000% (minimum 99%, Missing); spleen: 58.3333% (minimum 90%, Approved); stomach: 50.0000% (minimum 97%, Missing); thymus: 16.6667% (minimum 95%, Missing); thyroid gland: 87.5000% (minimum 95%, Missing); urinary bladder: 77.7778% (minimum 97%, Missing)",-0.783333,-0.736667,-0.810513,0,4,partial,3.2,2.3,3.5,"bone marrow: 3.2 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186871,ERCC6L,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 17.9487% (minimum 75%, Missing); colon: 43.7500% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 38.8889% (minimum 70%, Missing); lymph node: 23.3333% (minimum 70%, Missing); rectum: 38.8889% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); skin: 53.8462% (minimum 65%, Missing); small intestine: 53.8462% (minimum 75%, Missing); smooth muscle: 70.0000% (minimum 75%, Missing); spleen: 58.3333% (minimum 60%, Approved); stomach: 50.0000% (minimum 70%, Missing); thymus: 16.6667% (minimum 65%, Missing)",-0.483333,-0.466667,-0.570513,0,4,partial,3.2,2.3,3.5,"bone marrow: 3.2 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186871,ERCC6L,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 17.9487% (minimum 75%, Missing); colon: 43.7500% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 38.8889% (minimum 70%, Missing); lymph node: 23.3333% (minimum 70%, Missing); rectum: 38.8889% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); skin: 53.8462% (minimum 65%, Missing); small intestine: 53.8462% (minimum 75%, Missing); smooth muscle: 70.0000% (minimum 75%, Missing); spleen: 58.3333% (minimum 60%, Approved); stomach: 50.0000% (minimum 70%, Missing); thymus: 16.6667% (minimum 65%, Missing)",-0.483333,-0.466667,-0.570513,0,4,partial,3.2,2.3,3.5,"bone marrow: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186871,ERCC6L,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 17.9487% (minimum 75%, Missing); colon: 43.7500% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 38.8889% (minimum 70%, Missing); lymph node: 23.3333% (minimum 70%, Missing); rectum: 38.8889% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); skin: 53.8462% (minimum 65%, Missing); small intestine: 53.8462% (minimum 75%, Missing); smooth muscle: 70.0000% (minimum 75%, Missing); spleen: 58.3333% (minimum 60%, Approved); stomach: 50.0000% (minimum 70%, Missing); thymus: 16.6667% (minimum 65%, Missing)",-0.483333,-0.466667,-0.570513,0,4,partial,3.2,2.3,3.5,"bone marrow: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186871,ERCC6L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 17.9487% (minimum 75%, Baseline (adaptation disabled)); colon: 43.7500% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 38.8889% (minimum 70%, Baseline (adaptation disabled)); lymph node: 23.3333% (minimum 70%, Baseline (adaptation disabled)); rectum: 38.8889% (minimum 70%, Baseline (adaptation disabled)); retina: 63.6364% (minimum 75%, Baseline (adaptation disabled)); skin: 53.8462% (minimum 65%, Baseline (adaptation disabled)); small intestine: 53.8462% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.3333% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 16.6667% (minimum 65%, Baseline (adaptation disabled))",-0.483333,-0.466667,-0.570513,0,4,partial,3.2,2.3,3.5,"bone marrow: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186871,ERCC6L,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 80.3922% (minimum 99%, Missing); basal ganglia: 91.1111% (minimum 99%, Missing); cerebellum: 97.6190% (minimum 99%, Missing); cerebral cortex: 91.1111% (minimum 99%, Missing); choroid plexus: 97.6190% (minimum 99%, Missing); hippocampal formation: 93.1818% (minimum 99%, Missing); hypothalamus: 78.8462% (minimum 99%, Missing); kidney: 82.0000% (minimum 99%, Missing); midbrain: 87.2340% (minimum 99%, Missing); pituitary gland: 95.3488% (minimum 99%, Missing); retina: 82.0000% (minimum 99%, Missing); skin: 93.1818% (minimum 95%, Missing); spinal cord: 97.6190% (minimum 99%, Missing); thyroid gland: 82.0000% (minimum 95%, Missing)",-0.13,0.00619048,-0.201538,0,80,unavailable,1.1,0.1,0.9,"hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186897,C1QL4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17,0.27619,0.0384615,0,80,unavailable,1.1,0.1,0.9,"hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186897,C1QL4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17,0.27619,0.0384615,0,80,unavailable,1.1,0.1,0.9,"hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186897,C1QL4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17,0.27619,0.0384615,0,80,unavailable,1.1,0.1,0.9,"hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186897,C1QL4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17,0.27619,0.0384615,0,80,unavailable,1.1,0.1,0.9,"hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186897,C1QL4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6587% (minimum 95%, Uncertain); adrenal gland: 74.1329% (minimum 99%, Missing); amygdala: 78.6810% (minimum 99%, Missing); basal ganglia: 76.5672% (minimum 99%, Missing); bone marrow: 58.3618% (minimum 99%, Missing); cerebellum: 80.6604% (minimum 99%, Uncertain); cerebral cortex: 79.9065% (minimum 99%, Missing); choroid plexus: 69.7011% (minimum 99%, Missing); colon: 67.4113% (minimum 97%, Missing); duodenum: 71.6480% (minimum 99%, Missing); esophagus: 52.5615% (minimum 97%, Missing); heart muscle: 66.1082% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 84.6535% (minimum 99%, Missing); kidney: 69.3243% (minimum 99%, Missing); liver: 58.6957% (minimum 99%, Missing); lung: 72.8693% (minimum 99%, Missing); lymph node: 71.1512% (minimum 97%, Missing); midbrain: 82.0800% (minimum 99%, Missing); pancreas: 52.7235% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); pituitary gland: 76.2259% (minimum 99%, Missing); rectum: 79.1667% (minimum 97%, Missing); retina: 66.1082% (minimum 99%, Missing); salivary gland: 57.6404% (minimum 97%, Missing); skeletal muscle: 76.5672% (minimum 99%, Uncertain); skin: 55.2802% (minimum 95%, Missing); small intestine: 68.1275% (minimum 99%, Missing); smooth muscle: 84.7934% (minimum 99%, Uncertain); spinal cord: 84.7934% (minimum 99%, Missing); spleen: 70.6612% (minimum 95%, Uncertain); stomach: 66.8840% (minimum 97%, Missing); thymus: 73.6011% (minimum 95%, Missing); thyroid gland: 74.0260% (minimum 95%, Missing); tongue: 79.2890% (minimum 97%, Missing); urinary bladder: 66.8840% (minimum 97%, Missing)",-0.397198,-0.444385,-0.462765,0,3,partial,46,46.3,41.5,"esophagus: 46.3 nTPM (protected, limit 2); pancreas: 46 nTPM (vital, limit 1); skin: 41.5 nTPM (manageable, limit 5); salivary gland: 37.7 nTPM (protected, limit 2); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (manageable, limit 5); retina: 26.3 nTPM (vital, limit 1); heart muscle: 26.3 nTPM (vital, limit 1); stomach: 25.4 nTPM (protected, limit 2); urinary bladder: 25.4 nTPM (protected, limit 2); colon: 24.8 nTPM (protected, limit 2); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); spleen: 21.3 nTPM (manageable, limit 5); lymph node: 20.8 nTPM (protected, limit 2); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thymus: 18.4 nTPM (manageable, limit 5); thyroid gland: 18 nTPM (manageable, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 2); pituitary gland: 16 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 2); tongue: 13.4 nTPM (protected, limit 2); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186918,ZNF395,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6587% (minimum 65%, Uncertain); adrenal gland: 74.1329% (minimum 75%, Missing); bone marrow: 58.3618% (minimum 75%, Missing); choroid plexus: 69.7011% (minimum 75%, Missing); colon: 67.4113% (minimum 70%, Missing); duodenum: 71.6480% (minimum 75%, Missing); esophagus: 52.5615% (minimum 70%, Missing); heart muscle: 66.1082% (minimum 75%, Missing); kidney: 69.3243% (minimum 75%, Missing); liver: 58.6957% (minimum 75%, Missing); lung: 72.8693% (minimum 75%, Missing); pancreas: 52.7235% (minimum 75%, Missing); retina: 66.1082% (minimum 75%, Missing); salivary gland: 57.6404% (minimum 70%, Missing); skin: 55.2802% (minimum 65%, Missing); small intestine: 68.1275% (minimum 75%, Missing); stomach: 66.8840% (minimum 70%, Missing); urinary bladder: 66.8840% (minimum 70%, Missing)",-0.0971983,-0.174385,-0.222765,0,3,partial,46,46.3,41.5,"esophagus: 46.3 nTPM (protected, limit 2); pancreas: 46 nTPM (vital, limit 1); skin: 41.5 nTPM (manageable, limit 5); salivary gland: 37.7 nTPM (protected, limit 2); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (manageable, limit 5); retina: 26.3 nTPM (vital, limit 1); heart muscle: 26.3 nTPM (vital, limit 1); stomach: 25.4 nTPM (protected, limit 2); urinary bladder: 25.4 nTPM (protected, limit 2); colon: 24.8 nTPM (protected, limit 2); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); spleen: 21.3 nTPM (manageable, limit 5); lymph node: 20.8 nTPM (protected, limit 2); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thymus: 18.4 nTPM (manageable, limit 5); thyroid gland: 18 nTPM (manageable, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 2); pituitary gland: 16 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 2); tongue: 13.4 nTPM (protected, limit 2); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186918,ZNF395,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6587% (minimum 65%, Uncertain); adrenal gland: 74.1329% (minimum 75%, Missing); bone marrow: 58.3618% (minimum 75%, Missing); choroid plexus: 69.7011% (minimum 75%, Missing); colon: 67.4113% (minimum 70%, Missing); duodenum: 71.6480% (minimum 75%, Missing); esophagus: 52.5615% (minimum 70%, Missing); heart muscle: 66.1082% (minimum 75%, Missing); kidney: 69.3243% (minimum 75%, Missing); liver: 58.6957% (minimum 75%, Missing); lung: 72.8693% (minimum 75%, Missing); pancreas: 52.7235% (minimum 75%, Missing); retina: 66.1082% (minimum 75%, Missing); salivary gland: 57.6404% (minimum 70%, Missing); skin: 55.2802% (minimum 65%, Missing); small intestine: 68.1275% (minimum 75%, Missing); stomach: 66.8840% (minimum 70%, Missing); urinary bladder: 66.8840% (minimum 70%, Missing)",-0.0971983,-0.174385,-0.222765,0,3,partial,46,46.3,41.5,"esophagus: 46.3 nTPM (protected, limit 3); pancreas: 46 nTPM (vital, limit 1); skin: 41.5 nTPM (manageable, limit 5); salivary gland: 37.7 nTPM (protected, limit 3); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (manageable, limit 5); retina: 26.3 nTPM (vital, limit 1); heart muscle: 26.3 nTPM (vital, limit 1); stomach: 25.4 nTPM (protected, limit 3); urinary bladder: 25.4 nTPM (protected, limit 3); colon: 24.8 nTPM (protected, limit 3); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); spleen: 21.3 nTPM (manageable, limit 5); lymph node: 20.8 nTPM (protected, limit 3); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thymus: 18.4 nTPM (manageable, limit 5); thyroid gland: 18 nTPM (manageable, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 3); pituitary gland: 16 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 3); tongue: 13.4 nTPM (protected, limit 3); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186918,ZNF395,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6587% (minimum 65%, Uncertain); adrenal gland: 74.1329% (minimum 75%, Missing); bone marrow: 58.3618% (minimum 75%, Missing); choroid plexus: 69.7011% (minimum 75%, Missing); colon: 67.4113% (minimum 70%, Missing); duodenum: 71.6480% (minimum 75%, Missing); esophagus: 52.5615% (minimum 70%, Missing); heart muscle: 66.1082% (minimum 75%, Missing); kidney: 69.3243% (minimum 75%, Missing); liver: 58.6957% (minimum 75%, Missing); lung: 72.8693% (minimum 75%, Missing); pancreas: 52.7235% (minimum 75%, Missing); retina: 66.1082% (minimum 75%, Missing); salivary gland: 57.6404% (minimum 70%, Missing); skin: 55.2802% (minimum 65%, Missing); small intestine: 68.1275% (minimum 75%, Missing); stomach: 66.8840% (minimum 70%, Missing); urinary bladder: 66.8840% (minimum 70%, Missing)",-0.0971983,-0.174385,-0.222765,0,3,partial,46,46.3,41.5,"esophagus: 46.3 nTPM (protected, limit 3); pancreas: 46 nTPM (vital, limit 1); skin: 41.5 nTPM (manageable, limit 5); salivary gland: 37.7 nTPM (protected, limit 3); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (manageable, limit 5); retina: 26.3 nTPM (vital, limit 1); heart muscle: 26.3 nTPM (vital, limit 1); stomach: 25.4 nTPM (protected, limit 3); urinary bladder: 25.4 nTPM (protected, limit 3); colon: 24.8 nTPM (protected, limit 3); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); spleen: 21.3 nTPM (manageable, limit 5); lymph node: 20.8 nTPM (protected, limit 3); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thymus: 18.4 nTPM (manageable, limit 5); thyroid gland: 18 nTPM (manageable, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 3); pituitary gland: 16 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 3); tongue: 13.4 nTPM (protected, limit 3); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186918,ZNF395,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6587% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 74.1329% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 58.3618% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.7011% (minimum 75%, Baseline (adaptation disabled)); colon: 67.4113% (minimum 70%, Baseline (adaptation disabled)); duodenum: 71.6480% (minimum 75%, Baseline (adaptation disabled)); esophagus: 52.5615% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.1082% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.3243% (minimum 75%, Baseline (adaptation disabled)); liver: 58.6957% (minimum 75%, Baseline (adaptation disabled)); lung: 72.8693% (minimum 75%, Baseline (adaptation disabled)); pancreas: 52.7235% (minimum 75%, Baseline (adaptation disabled)); retina: 66.1082% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 57.6404% (minimum 70%, Baseline (adaptation disabled)); skin: 55.2802% (minimum 65%, Baseline (adaptation disabled)); small intestine: 68.1275% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.8840% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 66.8840% (minimum 70%, Baseline (adaptation disabled))",-0.0971983,-0.174385,-0.222765,0,3,partial,46,46.3,41.5,"esophagus: 46.3 nTPM (protected, limit 3); pancreas: 46 nTPM (vital, limit 1); skin: 41.5 nTPM (manageable, limit 5); salivary gland: 37.7 nTPM (protected, limit 3); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (manageable, limit 5); retina: 26.3 nTPM (vital, limit 1); heart muscle: 26.3 nTPM (vital, limit 1); stomach: 25.4 nTPM (protected, limit 3); urinary bladder: 25.4 nTPM (protected, limit 3); colon: 24.8 nTPM (protected, limit 3); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); spleen: 21.3 nTPM (manageable, limit 5); lymph node: 20.8 nTPM (protected, limit 3); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thymus: 18.4 nTPM (manageable, limit 5); thyroid gland: 18 nTPM (manageable, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 3); pituitary gland: 16 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 3); tongue: 13.4 nTPM (protected, limit 3); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186918,ZNF395,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.1818% (minimum 99%, Missing); amygdala: 93.7143% (minimum 99%, Missing); basal ganglia: 91.6201% (minimum 99%, Missing); cerebellum: 98.2036% (minimum 99%, Missing); cerebral cortex: 90.6077% (minimum 99%, Missing); choroid plexus: 83.2487% (minimum 99%, Missing); duodenum: 97.0414% (minimum 99%, Missing); heart muscle: 95.9064% (minimum 99%, Missing); hippocampal formation: 91.6201% (minimum 99%, Missing); hypothalamus: 90.6077% (minimum 99%, Missing); kidney: 82.4121% (minimum 99%, Missing); liver: 95.9064% (minimum 99%, Missing); lung: 91.1111% (minimum 99%, Missing); midbrain: 94.2529% (minimum 99%, Missing); pancreas: 97.6190% (minimum 99%, Missing); parathyroid gland: 89.1304% (minimum 97%, Missing); pituitary gland: 93.1818% (minimum 99%, Missing); retina: 82.4121% (minimum 99%, Missing); salivary gland: 96.4706% (minimum 97%, Missing); small intestine: 98.2036% (minimum 99%, Missing); smooth muscle: 97.6190% (minimum 99%, Missing); spinal cord: 94.2529% (minimum 99%, Missing); stomach: 94.7977% (minimum 97%, Missing); thyroid gland: 82.0000% (minimum 95%, Missing)",-0.13,-0.0786957,-0.165879,0,80,unavailable,3.5,2,3.6,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186952,TMEM232,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17,0.191304,0.0741206,0,80,unavailable,3.5,2,3.6,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186952,TMEM232,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17,0.191304,0.0741206,0,80,unavailable,3.5,2,3.6,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186952,TMEM232,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17,0.191304,0.0741206,0,80,unavailable,3.5,2,3.6,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186952,TMEM232,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17,0.191304,0.0741206,0,80,unavailable,3.5,2,3.6,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186952,TMEM232,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.7213% (minimum 99%, Missing); amygdala: 97.1193% (minimum 99%, Missing); basal ganglia: 95.9350% (minimum 99%, Missing); cerebellum: 98.7448% (minimum 99%, Missing); cerebral cortex: 96.7213% (minimum 99%, Missing); choroid plexus: 88.3895% (minimum 99%, Missing); duodenum: 98.7448% (minimum 99%, Missing); heart muscle: 98.3333% (minimum 99%, Missing); hippocampal formation: 96.7213% (minimum 99%, Missing); hypothalamus: 95.9350% (minimum 99%, Missing); kidney: 94.7791% (minimum 99%, Missing); liver: 98.3333% (minimum 99%, Missing); lung: 95.5466% (minimum 99%, Missing); midbrain: 98.3333% (minimum 99%, Missing); pancreas: 95.1613% (minimum 99%, Missing); parathyroid gland: 91.1197% (minimum 97%, Missing); pituitary gland: 92.5490% (minimum 99%, Missing); retina: 88.7218% (minimum 99%, Missing); smooth muscle: 98.3333% (minimum 99%, Missing); spinal cord: 98.7448% (minimum 99%, Missing); stomach: 96.7213% (minimum 97%, Missing); thyroid gland: 88.7218% (minimum 95%, Missing)",-0.062782,-0.0588031,-0.106105,0,80,unavailable,3.1,2.3,3,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186976,EFCAB6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.237218,0.211197,0.133895,0,80,unavailable,3.1,2.3,3,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186976,EFCAB6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.237218,0.211197,0.133895,0,80,unavailable,3.1,2.3,3,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186976,EFCAB6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.237218,0.211197,0.133895,0,80,unavailable,3.1,2.3,3,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186976,EFCAB6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.237218,0.211197,0.133895,0,80,unavailable,3.1,2.3,3,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000186976,EFCAB6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187003,ACTL7A,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187003,ACTL7A,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187003,ACTL7A,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187003,ACTL7A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187003,ACTL7A,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187005,KRTAP21-1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187005,KRTAP21-1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187005,KRTAP21-1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187005,KRTAP21-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187005,KRTAP21-1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.2432% (minimum 99%, Missing); bone marrow: 83.6202% (minimum 95%, Enhanced); cerebellum: 87.2986% (minimum 99%, Missing); colon: 83.7693% (minimum 97%, Missing); duodenum: 61.4747% (minimum 99%, Missing); esophagus: 80.8840% (minimum 97%, Missing); kidney: 69.6146% (minimum 99%, Missing); liver: 52.8507% (minimum 99%, Missing); parathyroid gland: 84.4218% (minimum 97%, Missing); pituitary gland: 77.5028% (minimum 99%, Missing); rectum: 95.5254% (minimum 97%, Missing); retina: 55.1900% (minimum 99%, Missing); small intestine: 61.7712% (minimum 99%, Missing)",0.0112798,-0.16116,-0.461493,0,3,partial,125.7,33.3,89.6,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); skin: 89.6 nTPM (manageable, limit 30); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 2); bone marrow: 27.6 nTPM (vital, limit 6); colon: 27.3 nTPM (protected, limit 2); parathyroid gland: 26 nTPM (protected, limit 2); cerebellum: 20.5 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); adrenal gland: 5.5 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187017,ESPN,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 61.4747% (minimum 75%, Missing); kidney: 69.6146% (minimum 75%, Missing); liver: 52.8507% (minimum 75%, Missing); retina: 55.1900% (minimum 75%, Missing); small intestine: 61.7712% (minimum 75%, Missing)",0.11128,0.10884,-0.221493,0,3,partial,125.7,33.3,89.6,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); skin: 89.6 nTPM (manageable, limit 30); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 2); bone marrow: 27.6 nTPM (vital, limit 6); colon: 27.3 nTPM (protected, limit 2); parathyroid gland: 26 nTPM (protected, limit 2); cerebellum: 20.5 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); adrenal gland: 5.5 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187017,ESPN,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 61.4747% (minimum 75%, Missing); kidney: 69.6146% (minimum 75%, Missing); liver: 52.8507% (minimum 75%, Missing); retina: 55.1900% (minimum 75%, Missing); small intestine: 61.7712% (minimum 75%, Missing)",0.11128,0.10884,-0.221493,0,3,partial,125.7,33.3,89.6,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); skin: 89.6 nTPM (manageable, limit 30); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 3); bone marrow: 27.6 nTPM (vital, limit 6); colon: 27.3 nTPM (protected, limit 3); parathyroid gland: 26 nTPM (protected, limit 3); cerebellum: 20.5 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); adrenal gland: 5.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187017,ESPN,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 61.4747% (minimum 75%, Missing); kidney: 69.6146% (minimum 75%, Missing); liver: 52.8507% (minimum 75%, Missing); retina: 55.1900% (minimum 75%, Missing); small intestine: 61.7712% (minimum 75%, Missing)",0.11128,0.10884,-0.221493,0,3,partial,125.7,33.3,89.6,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); skin: 89.6 nTPM (manageable, limit 30); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 3); bone marrow: 27.6 nTPM (vital, limit 6); colon: 27.3 nTPM (protected, limit 3); parathyroid gland: 26 nTPM (protected, limit 3); cerebellum: 20.5 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); adrenal gland: 5.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187017,ESPN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 61.4747% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.6146% (minimum 75%, Baseline (adaptation disabled)); liver: 52.8507% (minimum 75%, Baseline (adaptation disabled)); retina: 55.1900% (minimum 75%, Baseline (adaptation disabled)); skin: 61.1280% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.7712% (minimum 75%, Baseline (adaptation disabled))",-0.0387202,0.10884,-0.221493,0,3,partial,125.7,33.3,89.6,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); skin: 89.6 nTPM (manageable, limit 5); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 3); bone marrow: 27.6 nTPM (vital, limit 1); colon: 27.3 nTPM (protected, limit 3); parathyroid gland: 26 nTPM (protected, limit 3); cerebellum: 20.5 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 3); rectum: 6.6 nTPM (protected, limit 3); adrenal gland: 5.5 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187017,ESPN,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 51.2121% (minimum 95%, Missing); adrenal gland: 40.6250% (minimum 99%, Missing); amygdala: 46.1749% (minimum 99%, Missing); basal ganglia: 50.0000% (minimum 99%, Missing); bone marrow: 80.4762% (minimum 99%, Missing); cerebellum: 78.6047% (minimum 99%, Missing); cerebral cortex: 47.4719% (minimum 99%, Missing); choroid plexus: 62.8253% (minimum 99%, Missing); colon: 59.0909% (minimum 97%, Missing); duodenum: 80.4762% (minimum 99%, Missing); esophagus: 62.5926% (minimum 97%, Missing); heart muscle: 48.8439% (minimum 99%, Missing); hippocampal formation: 50.7508% (minimum 99%, Missing); hypothalamus: 52.0000% (minimum 99%, Missing); kidney: 39.3939% (minimum 99%, Missing); liver: 48.9855% (minimum 99%, Missing); lung: 57.8767% (minimum 99%, Missing); lymph node: 84.0796% (minimum 97%, Missing); midbrain: 50.2976% (minimum 99%, Missing); pancreas: 45.4301% (minimum 99%, Missing); parathyroid gland: 69.8347% (minimum 97%, Missing); pituitary gland: 49.4152% (minimum 99%, Missing); rectum: 88.4817% (minimum 97%, Missing); retina: 86.2245% (minimum 99%, Missing); salivary gland: 60.1423% (minimum 97%, Missing); skeletal muscle: 46.8144% (minimum 99%, Missing); skin: 41.3203% (minimum 95%, Missing); small intestine: 69.5473% (minimum 99%, Missing); smooth muscle: 83.2512% (minimum 99%, Missing); spinal cord: 62.5926% (minimum 99%, Missing); spleen: 57.8767% (minimum 95%, Missing); stomach: 54.5161% (minimum 97%, Missing); thymus: 80.8612% (minimum 95%, Missing); thyroid gland: 46.4286% (minimum 95%, Missing); tongue: 84.5000% (minimum 97%, Missing); urinary bladder: 57.4830% (minimum 97%, Missing)",-0.536797,-0.424839,-0.596061,0,6,partial,26,14.1,24,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); skin: 24 nTPM (manageable, limit 5); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (manageable, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (manageable, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 2); urinary bladder: 12.5 nTPM (protected, limit 2); lung: 12.3 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); colon: 11.7 nTPM (protected, limit 2); salivary gland: 11.2 nTPM (protected, limit 2); spinal cord: 10.1 nTPM (vital, limit 1); esophagus: 10.1 nTPM (protected, limit 2); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); tongue: 3.1 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187024,PTRH1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 51.2121% (minimum 65%, Missing); adrenal gland: 40.6250% (minimum 75%, Missing); amygdala: 46.1749% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebral cortex: 47.4719% (minimum 75%, Missing); choroid plexus: 62.8253% (minimum 75%, Missing); colon: 59.0909% (minimum 70%, Missing); esophagus: 62.5926% (minimum 70%, Missing); heart muscle: 48.8439% (minimum 75%, Missing); hippocampal formation: 50.7508% (minimum 75%, Missing); hypothalamus: 52.0000% (minimum 75%, Missing); kidney: 39.3939% (minimum 75%, Missing); liver: 48.9855% (minimum 75%, Missing); lung: 57.8767% (minimum 75%, Missing); midbrain: 50.2976% (minimum 75%, Missing); pancreas: 45.4301% (minimum 75%, Missing); parathyroid gland: 69.8347% (minimum 70%, Missing); pituitary gland: 49.4152% (minimum 75%, Missing); salivary gland: 60.1423% (minimum 70%, Missing); skeletal muscle: 46.8144% (minimum 75%, Missing); skin: 41.3203% (minimum 65%, Missing); small intestine: 69.5473% (minimum 75%, Missing); spinal cord: 62.5926% (minimum 75%, Missing); spleen: 57.8767% (minimum 65%, Missing); stomach: 54.5161% (minimum 70%, Missing); thyroid gland: 46.4286% (minimum 65%, Missing); urinary bladder: 57.4830% (minimum 70%, Missing)",-0.236797,-0.154839,-0.356061,0,6,partial,26,14.1,24,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); skin: 24 nTPM (manageable, limit 5); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (manageable, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (manageable, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 2); urinary bladder: 12.5 nTPM (protected, limit 2); lung: 12.3 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); colon: 11.7 nTPM (protected, limit 2); salivary gland: 11.2 nTPM (protected, limit 2); spinal cord: 10.1 nTPM (vital, limit 1); esophagus: 10.1 nTPM (protected, limit 2); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); tongue: 3.1 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187024,PTRH1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 51.2121% (minimum 65%, Missing); adrenal gland: 40.6250% (minimum 75%, Missing); amygdala: 46.1749% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebral cortex: 47.4719% (minimum 75%, Missing); choroid plexus: 62.8253% (minimum 75%, Missing); colon: 59.0909% (minimum 70%, Missing); esophagus: 62.5926% (minimum 70%, Missing); heart muscle: 48.8439% (minimum 75%, Missing); hippocampal formation: 50.7508% (minimum 75%, Missing); hypothalamus: 52.0000% (minimum 75%, Missing); kidney: 39.3939% (minimum 75%, Missing); liver: 48.9855% (minimum 75%, Missing); lung: 57.8767% (minimum 75%, Missing); midbrain: 50.2976% (minimum 75%, Missing); pancreas: 45.4301% (minimum 75%, Missing); parathyroid gland: 69.8347% (minimum 70%, Missing); pituitary gland: 49.4152% (minimum 75%, Missing); salivary gland: 60.1423% (minimum 70%, Missing); skeletal muscle: 46.8144% (minimum 75%, Missing); skin: 41.3203% (minimum 65%, Missing); small intestine: 69.5473% (minimum 75%, Missing); spinal cord: 62.5926% (minimum 75%, Missing); spleen: 57.8767% (minimum 65%, Missing); stomach: 54.5161% (minimum 70%, Missing); thyroid gland: 46.4286% (minimum 65%, Missing); urinary bladder: 57.4830% (minimum 70%, Missing)",-0.236797,-0.154839,-0.356061,0,6,partial,26,14.1,24,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); skin: 24 nTPM (manageable, limit 5); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (manageable, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (manageable, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 3); urinary bladder: 12.5 nTPM (protected, limit 3); lung: 12.3 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); colon: 11.7 nTPM (protected, limit 3); salivary gland: 11.2 nTPM (protected, limit 3); esophagus: 10.1 nTPM (protected, limit 3); spinal cord: 10.1 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 3); tongue: 3.1 nTPM (protected, limit 3); retina: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187024,PTRH1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 51.2121% (minimum 65%, Missing); adrenal gland: 40.6250% (minimum 75%, Missing); amygdala: 46.1749% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebral cortex: 47.4719% (minimum 75%, Missing); choroid plexus: 62.8253% (minimum 75%, Missing); colon: 59.0909% (minimum 70%, Missing); esophagus: 62.5926% (minimum 70%, Missing); heart muscle: 48.8439% (minimum 75%, Missing); hippocampal formation: 50.7508% (minimum 75%, Missing); hypothalamus: 52.0000% (minimum 75%, Missing); kidney: 39.3939% (minimum 75%, Missing); liver: 48.9855% (minimum 75%, Missing); lung: 57.8767% (minimum 75%, Missing); midbrain: 50.2976% (minimum 75%, Missing); pancreas: 45.4301% (minimum 75%, Missing); parathyroid gland: 69.8347% (minimum 70%, Missing); pituitary gland: 49.4152% (minimum 75%, Missing); salivary gland: 60.1423% (minimum 70%, Missing); skeletal muscle: 46.8144% (minimum 75%, Missing); skin: 41.3203% (minimum 65%, Missing); small intestine: 69.5473% (minimum 75%, Missing); spinal cord: 62.5926% (minimum 75%, Missing); spleen: 57.8767% (minimum 65%, Missing); stomach: 54.5161% (minimum 70%, Missing); thyroid gland: 46.4286% (minimum 65%, Missing); urinary bladder: 57.4830% (minimum 70%, Missing)",-0.236797,-0.154839,-0.356061,0,6,partial,26,14.1,24,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); skin: 24 nTPM (manageable, limit 5); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (manageable, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (manageable, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 3); urinary bladder: 12.5 nTPM (protected, limit 3); lung: 12.3 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); colon: 11.7 nTPM (protected, limit 3); salivary gland: 11.2 nTPM (protected, limit 3); esophagus: 10.1 nTPM (protected, limit 3); spinal cord: 10.1 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 3); tongue: 3.1 nTPM (protected, limit 3); retina: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187024,PTRH1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 51.2121% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 40.6250% (minimum 75%, Baseline (adaptation disabled)); amygdala: 46.1749% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 50.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 47.4719% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 62.8253% (minimum 75%, Baseline (adaptation disabled)); colon: 59.0909% (minimum 70%, Baseline (adaptation disabled)); esophagus: 62.5926% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 48.8439% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.7508% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 52.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 39.3939% (minimum 75%, Baseline (adaptation disabled)); liver: 48.9855% (minimum 75%, Baseline (adaptation disabled)); lung: 57.8767% (minimum 75%, Baseline (adaptation disabled)); midbrain: 50.2976% (minimum 75%, Baseline (adaptation disabled)); pancreas: 45.4301% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.8347% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 49.4152% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.1423% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 46.8144% (minimum 75%, Baseline (adaptation disabled)); skin: 41.3203% (minimum 65%, Baseline (adaptation disabled)); small intestine: 69.5473% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.5926% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.8767% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.5161% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 46.4286% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 57.4830% (minimum 70%, Baseline (adaptation disabled))",-0.236797,-0.154839,-0.356061,0,6,partial,26,14.1,24,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); skin: 24 nTPM (manageable, limit 5); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (manageable, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (manageable, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 3); urinary bladder: 12.5 nTPM (protected, limit 3); lung: 12.3 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); colon: 11.7 nTPM (protected, limit 3); salivary gland: 11.2 nTPM (protected, limit 3); esophagus: 10.1 nTPM (protected, limit 3); spinal cord: 10.1 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 3); tongue: 3.1 nTPM (protected, limit 3); retina: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187024,PTRH1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 55.1724% (minimum 95%, Missing)",-0.398276,0.03,0.01,0,80,unavailable,0,0,1.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187026,KRTAP21-2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 55.1724% (minimum 65%, Missing)",-0.0982759,0.3,0.25,0,80,unavailable,0,0,1.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187026,KRTAP21-2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 55.1724% (minimum 65%, Missing)",-0.0982759,0.3,0.25,0,80,unavailable,0,0,1.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187026,KRTAP21-2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 55.1724% (minimum 65%, Missing)",-0.0982759,0.3,0.25,0,80,unavailable,0,0,1.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187026,KRTAP21-2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 55.1724% (minimum 65%, Baseline (adaptation disabled))",-0.0982759,0.3,0.25,0,80,unavailable,0,0,1.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187026,KRTAP21-2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 33.3333% (minimum 97%, Missing); retina: 0.0769% (minimum 99%, Missing)",0.05,-0.636667,-0.989231,0,80,unavailable,130,0.2,0,"retina: 130 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187033,SAMD7,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 33.3333% (minimum 70%, Missing); retina: 0.0769% (minimum 75%, Missing)",0.35,-0.366667,-0.749231,0,80,unavailable,130,0.2,0,"retina: 130 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187033,SAMD7,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 33.3333% (minimum 70%, Missing); retina: 0.0769% (minimum 75%, Missing)",0.35,-0.366667,-0.749231,0,80,unavailable,130,0.2,0,"retina: 130 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187033,SAMD7,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 33.3333% (minimum 70%, Missing); retina: 0.0769% (minimum 75%, Missing)",0.35,-0.366667,-0.749231,0,80,unavailable,130,0.2,0,"retina: 130 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187033,SAMD7,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 33.3333% (minimum 70%, Baseline (adaptation disabled)); retina: 0.0769% (minimum 75%, Baseline (adaptation disabled))",0.35,-0.366667,-0.749231,0,80,unavailable,130,0.2,0,"retina: 130 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187033,SAMD7,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0451456,0.03,0.01,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187066,TMEM262,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.345146,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187066,TMEM262,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.345146,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187066,TMEM262,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.345146,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187066,TMEM262,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.345146,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187066,TMEM262,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 99%, Missing)",0.05,0.03,-0.656667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187080,OR2AK2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187080,OR2AK2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187080,OR2AK2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187080,OR2AK2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187080,OR2AK2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187082,DEFB106B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187082,DEFB106B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187082,DEFB106B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187082,DEFB106B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187082,DEFB106B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.6897% (minimum 99%, Missing); basal ganglia: 94.0678% (minimum 99%, Missing); bone marrow: 93.2773% (minimum 95%, Enhanced); cerebellum: 84.7328% (minimum 95%, Enhanced); cerebral cortex: 91.7355% (minimum 95%, Enhanced); colon: 96.5217% (minimum 97%, Missing); duodenum: 86.0465% (minimum 95%, Enhanced); hippocampal formation: 94.8718% (minimum 99%, Missing); hypothalamus: 95.6897% (minimum 99%, Missing); kidney: 96.5217% (minimum 99%, Missing); liver: 93.2773% (minimum 95%, Enhanced); lymph node: 88.0952% (minimum 97%, Missing); midbrain: 96.5217% (minimum 99%, Missing); pancreas: 93.2773% (minimum 95%, Enhanced); pituitary gland: 95.6897% (minimum 99%, Missing); retina: 79.8561% (minimum 99%, Missing); skeletal muscle: 86.0465% (minimum 95%, Enhanced); small intestine: 94.0678% (minimum 95%, Enhanced); spinal cord: 95.6897% (minimum 99%, Missing); stomach: 94.0678% (minimum 97%, Missing)",0.05,-0.0890476,-0.191439,0,4,partial,2.8,1.5,3.4,"retina: 2.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187105,HEATR4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.265517,0.180952,0.0485612,0,4,partial,2.8,1.5,3.4,"retina: 2.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187105,HEATR4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.265517,0.180952,0.0485612,0,4,partial,2.8,1.5,3.4,"retina: 2.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187105,HEATR4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.265517,0.180952,0.0485612,0,4,partial,2.8,1.5,3.4,"retina: 2.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187105,HEATR4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.115517,0.180952,0.0485612,0,4,partial,2.8,1.5,3.4,"retina: 2.8 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187105,HEATR4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.9524% (minimum 95%, Missing); adrenal gland: 94.4444% (minimum 99%, Missing); amygdala: 8.2524% (minimum 99%, Missing); basal ganglia: 6.8826% (minimum 99%, Missing); bone marrow: 89.4737% (minimum 99%, Missing); cerebellum: 62.9630% (minimum 99%, Missing); cerebral cortex: 4.7753% (minimum 99%, Missing); choroid plexus: 77.2727% (minimum 99%, Missing); colon: 77.2727% (minimum 97%, Missing); duodenum: 94.4444% (minimum 99%, Missing); heart muscle: 94.4444% (minimum 99%, Missing); hippocampal formation: 7.8341% (minimum 99%, Missing); hypothalamus: 10.6250% (minimum 99%, Missing); kidney: 94.4444% (minimum 99%, Missing); liver: 94.4444% (minimum 99%, Missing); lung: 89.4737% (minimum 99%, Missing); lymph node: 94.4444% (minimum 97%, Missing); midbrain: 23.6111% (minimum 99%, Missing); pancreas: 77.2727% (minimum 99%, Missing); pituitary gland: 11.4865% (minimum 99%, Missing); rectum: 94.4444% (minimum 97%, Missing); retina: 70.8333% (minimum 99%, Missing); salivary gland: 94.4444% (minimum 97%, Missing); skeletal muscle: 94.4444% (minimum 99%, Missing); small intestine: 89.4737% (minimum 99%, Missing); smooth muscle: 94.4444% (minimum 99%, Missing); spinal cord: 45.9459% (minimum 99%, Missing); spleen: 85.0000% (minimum 95%, Missing); stomach: 89.4737% (minimum 97%, Missing); thymus: 42.5000% (minimum 95%, Missing); thyroid gland: 41.4634% (minimum 95%, Missing); urinary bladder: 94.4444% (minimum 97%, Missing)",-0.535366,-0.197273,-0.942247,0,80,unavailable,33.9,0.5,2.4,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187122,SLIT1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 8.2524% (minimum 75%, Missing); basal ganglia: 6.8826% (minimum 75%, Missing); cerebellum: 62.9630% (minimum 75%, Missing); cerebral cortex: 4.7753% (minimum 75%, Missing); hippocampal formation: 7.8341% (minimum 75%, Missing); hypothalamus: 10.6250% (minimum 75%, Missing); midbrain: 23.6111% (minimum 75%, Missing); pituitary gland: 11.4865% (minimum 75%, Missing); retina: 70.8333% (minimum 75%, Missing); spinal cord: 45.9459% (minimum 75%, Missing); thymus: 42.5000% (minimum 65%, Missing); thyroid gland: 41.4634% (minimum 65%, Missing)",-0.235366,0.0727273,-0.702247,0,80,unavailable,33.9,0.5,2.4,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187122,SLIT1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 8.2524% (minimum 75%, Missing); basal ganglia: 6.8826% (minimum 75%, Missing); cerebellum: 62.9630% (minimum 75%, Missing); cerebral cortex: 4.7753% (minimum 75%, Missing); hippocampal formation: 7.8341% (minimum 75%, Missing); hypothalamus: 10.6250% (minimum 75%, Missing); midbrain: 23.6111% (minimum 75%, Missing); pituitary gland: 11.4865% (minimum 75%, Missing); retina: 70.8333% (minimum 75%, Missing); spinal cord: 45.9459% (minimum 75%, Missing); thymus: 42.5000% (minimum 65%, Missing); thyroid gland: 41.4634% (minimum 65%, Missing)",-0.235366,0.0727273,-0.702247,0,80,unavailable,33.9,0.5,2.4,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187122,SLIT1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 8.2524% (minimum 75%, Missing); basal ganglia: 6.8826% (minimum 75%, Missing); cerebellum: 62.9630% (minimum 75%, Missing); cerebral cortex: 4.7753% (minimum 75%, Missing); hippocampal formation: 7.8341% (minimum 75%, Missing); hypothalamus: 10.6250% (minimum 75%, Missing); midbrain: 23.6111% (minimum 75%, Missing); pituitary gland: 11.4865% (minimum 75%, Missing); retina: 70.8333% (minimum 75%, Missing); spinal cord: 45.9459% (minimum 75%, Missing); thymus: 42.5000% (minimum 65%, Missing); thyroid gland: 41.4634% (minimum 65%, Missing)",-0.235366,0.0727273,-0.702247,0,80,unavailable,33.9,0.5,2.4,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187122,SLIT1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 8.2524% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 6.8826% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.9630% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 4.7753% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 7.8341% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 10.6250% (minimum 75%, Baseline (adaptation disabled)); midbrain: 23.6111% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 11.4865% (minimum 75%, Baseline (adaptation disabled)); retina: 70.8333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 45.9459% (minimum 75%, Baseline (adaptation disabled)); thymus: 42.5000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 41.4634% (minimum 65%, Baseline (adaptation disabled))",-0.235366,0.0727273,-0.702247,0,80,unavailable,33.9,0.5,2.4,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187122,SLIT1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.6667% (minimum 99%, Missing); bone marrow: 92.5000% (minimum 99%, Missing); cerebellum: 92.5000% (minimum 99%, Missing); choroid plexus: 98.6667% (minimum 99%, Missing); duodenum: 96.1039% (minimum 99%, Missing); liver: 96.1039% (minimum 99%, Missing); pancreas: 94.8718% (minimum 99%, Missing); retina: 90.2439% (minimum 99%, Missing); small intestine: 98.6667% (minimum 99%, Missing); smooth muscle: 98.6667% (minimum 99%, Missing); spinal cord: 98.6667% (minimum 99%, Missing)",0.011039,0.0166667,-0.087561,0,80,unavailable,0.8,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187144,SPATA21,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.311039,0.286667,0.152439,0,80,unavailable,0.8,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187144,SPATA21,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.311039,0.286667,0.152439,0,80,unavailable,0.8,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187144,SPATA21,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.311039,0.286667,0.152439,0,80,unavailable,0.8,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187144,SPATA21,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.311039,0.286667,0.152439,0,80,unavailable,0.8,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187144,SPATA21,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.049053,0.0281079,0.00669343,0,8,partial,0.7,0.4,0.3,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187166,H1-7,admission_only,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.349053,0.298108,0.246693,0,8,partial,0.7,0.4,0.3,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187166,H1-7,selectivity_revised,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.349053,0.298108,0.246693,0,8,partial,0.7,0.4,0.3,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187166,H1-7,grid_revised,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.349053,0.298108,0.246693,0,8,partial,0.7,0.4,0.3,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187166,H1-7,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.34858,0.298108,0.246693,0,8,partial,0.7,0.4,0.3,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187166,H1-7,current_fixed,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 83.2260% (minimum 99%, Missing); basal ganglia: 74.8355% (minimum 99%, Missing); cerebellum: 89.5997% (minimum 95%, Enhanced); cerebral cortex: 79.0381% (minimum 95%, Enhanced); choroid plexus: 90.8597% (minimum 99%, Missing); heart muscle: 91.3267% (minimum 95%, Enhanced); hippocampal formation: 83.4458% (minimum 99%, Missing); hypothalamus: 85.7358% (minimum 99%, Missing); midbrain: 85.9172% (minimum 99%, Missing); pituitary gland: 82.8139% (minimum 99%, Missing); retina: 97.8321% (minimum 99%, Missing); skeletal muscle: 88.9271% (minimum 95%, Enhanced); spinal cord: 91.4148% (minimum 99%, Missing); tongue: 92.9389% (minimum 97%, Missing)",0.0426676,-0.0406113,-0.241645,0,2,partial,95.6,21.6,13.2,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 6); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 6); cerebellum: 33 nTPM (vital, limit 6); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 6); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 2); kidney: 14.2 nTPM (vital, limit 6); adrenal gland: 9.4 nTPM (vital, limit 6); pancreas: 8.5 nTPM (vital, limit 6); liver: 6.6 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187186,ENSG00000187186,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 74.8355% (minimum 75%, Missing)",0.342668,0.229389,-0.00164517,0,2,partial,95.6,21.6,13.2,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 6); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 6); cerebellum: 33 nTPM (vital, limit 6); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 6); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 2); kidney: 14.2 nTPM (vital, limit 6); adrenal gland: 9.4 nTPM (vital, limit 6); pancreas: 8.5 nTPM (vital, limit 6); liver: 6.6 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187186,ENSG00000187186,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 74.8355% (minimum 75%, Missing)",0.342668,0.229389,-0.00164517,0,2,partial,95.6,21.6,13.2,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 6); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 6); cerebellum: 33 nTPM (vital, limit 6); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 6); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 3); kidney: 14.2 nTPM (vital, limit 6); adrenal gland: 9.4 nTPM (vital, limit 6); pancreas: 8.5 nTPM (vital, limit 6); liver: 6.6 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187186,ENSG00000187186,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 74.8355% (minimum 75%, Missing)",0.342668,0.229389,-0.00164517,0,2,partial,95.6,21.6,13.2,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 6); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 6); cerebellum: 33 nTPM (vital, limit 6); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 6); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 3); kidney: 14.2 nTPM (vital, limit 6); adrenal gland: 9.4 nTPM (vital, limit 6); pancreas: 8.5 nTPM (vital, limit 6); liver: 6.6 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187186,ENSG00000187186,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 74.8355% (minimum 75%, Baseline (adaptation disabled))",0.30563,0.229389,-0.00164517,0,2,partial,95.6,21.6,13.2,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 1); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 1); cerebellum: 33 nTPM (vital, limit 1); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 1); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 3); kidney: 14.2 nTPM (vital, limit 1); thyroid gland: 13.2 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 3); adrenal gland: 9.4 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 3); salivary gland: 7.1 nTPM (protected, limit 3); liver: 6.6 nTPM (vital, limit 1); retina: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 3); stomach: 6.1 nTPM (protected, limit 3); adipose tissue: 5.8 nTPM (manageable, limit 5); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187186,ENSG00000187186,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.4172% (minimum 95%, Missing); adrenal gland: 83.0189% (minimum 99%, Missing); amygdala: 89.1892% (minimum 99%, Missing); basal ganglia: 83.5443% (minimum 99%, Missing); bone marrow: 96.3504% (minimum 99%, Missing); cerebellum: 81.9876% (minimum 99%, Missing); cerebral cortex: 86.8421% (minimum 99%, Missing); choroid plexus: 92.9577% (minimum 99%, Missing); colon: 86.8421% (minimum 97%, Missing); duodenum: 97.0588% (minimum 99%, Missing); esophagus: 93.6170% (minimum 97%, Missing); heart muscle: 84.6154% (minimum 99%, Missing); hippocampal formation: 86.8421% (minimum 99%, Missing); hypothalamus: 88.0000% (minimum 99%, Missing); kidney: 85.7143% (minimum 99%, Missing); liver: 78.5714% (minimum 99%, Missing); lung: 91.0345% (minimum 99%, Missing); lymph node: 93.6170% (minimum 97%, Missing); midbrain: 89.1892% (minimum 99%, Missing); pancreas: 88.0000% (minimum 99%, Missing); parathyroid gland: 91.6667% (minimum 97%, Missing); pituitary gland: 83.0189% (minimum 99%, Missing); rectum: 96.3504% (minimum 97%, Missing); retina: 85.1613% (minimum 99%, Missing); salivary gland: 90.4110% (minimum 97%, Missing); skeletal muscle: 84.6154% (minimum 99%, Missing); skin: 92.9577% (minimum 95%, Missing); small intestine: 88.0000% (minimum 99%, Missing); smooth muscle: 91.0345% (minimum 99%, Missing); spinal cord: 88.0000% (minimum 99%, Missing); spleen: 80.9816% (minimum 95%, Missing); stomach: 90.4110% (minimum 97%, Missing); thymus: 92.9577% (minimum 95%, Missing); thyroid gland: 85.1613% (minimum 95%, Missing); tongue: 91.0345% (minimum 97%, Missing); urinary bladder: 86.8421% (minimum 97%, Missing)",-0.140184,-0.101579,-0.204286,0,80,unavailable,3.6,2,3.1,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187187,ZNF546,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.159816,0.168421,0.0357143,0,80,unavailable,3.6,2,3.1,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187187,ZNF546,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.159816,0.168421,0.0357143,0,80,unavailable,3.6,2,3.1,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187187,ZNF546,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.159816,0.168421,0.0357143,0,80,unavailable,3.6,2,3.1,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187187,ZNF546,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.159816,0.168421,0.0357143,0,80,unavailable,3.6,2,3.1,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187187,ZNF546,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 82.3529% (minimum 90%, Approved); stomach: 70.0000% (minimum 95%, Approved)",-0.0764706,-0.25,0.01,0,1,partial,0,0.6,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187191,DAZ3,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.223529,0.05,0.25,0,1,partial,0,0.6,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187191,DAZ3,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.223529,0.05,0.25,0,1,partial,0,0.6,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187191,DAZ3,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.223529,0.05,0.25,0,1,partial,0,0.6,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187191,DAZ3,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.173529,0,0.25,0,1,partial,0,0.6,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187191,DAZ3,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 98.5507% (minimum 99%, Missing); liver: 95.7746% (minimum 99%, Missing); skeletal muscle: 76.4045% (minimum 99%, Missing); skin: 4.4156% (minimum 95%, Missing)",-0.905844,0.03,-0.225955,0,80,unavailable,2.1,0,147.2,"skin: 147.2 nTPM (manageable, limit 5); skeletal muscle: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187223,LCE2D,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.4156% (minimum 65%, Missing)",-0.605844,0.3,0.0140449,0,80,unavailable,2.1,0,147.2,"skin: 147.2 nTPM (manageable, limit 5); skeletal muscle: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187223,LCE2D,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.4156% (minimum 65%, Missing)",-0.605844,0.3,0.0140449,0,80,unavailable,2.1,0,147.2,"skin: 147.2 nTPM (manageable, limit 5); skeletal muscle: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187223,LCE2D,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.4156% (minimum 65%, Missing)",-0.605844,0.3,0.0140449,0,80,unavailable,2.1,0,147.2,"skin: 147.2 nTPM (manageable, limit 5); skeletal muscle: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187223,LCE2D,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.4156% (minimum 65%, Baseline (adaptation disabled))",-0.605844,0.3,0.0140449,0,80,unavailable,2.1,0,147.2,"skin: 147.2 nTPM (manageable, limit 5); skeletal muscle: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187223,LCE2D,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.3333% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); heart muscle: 82.3529% (minimum 99%, Missing); lung: 97.6744% (minimum 99%, Missing); lymph node: 95.4545% (minimum 97%, Missing); pancreas: 93.3333% (minimum 99%, Missing); small intestine: 97.6744% (minimum 99%, Missing); spleen: 10.1449% (minimum 95%, Missing)",-0.848551,-0.0154545,-0.166471,0,80,unavailable,0.9,0.2,37.2,"spleen: 37.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187268,FAM9C,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spleen: 10.1449% (minimum 65%, Missing)",-0.548551,0.254545,0.0735294,0,80,unavailable,0.9,0.2,37.2,"spleen: 37.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187268,FAM9C,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spleen: 10.1449% (minimum 65%, Missing)",-0.548551,0.254545,0.0735294,0,80,unavailable,0.9,0.2,37.2,"spleen: 37.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187268,FAM9C,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spleen: 10.1449% (minimum 65%, Missing)",-0.548551,0.254545,0.0735294,0,80,unavailable,0.9,0.2,37.2,"spleen: 37.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187268,FAM9C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spleen: 10.1449% (minimum 65%, Baseline (adaptation disabled))",-0.548551,0.254545,0.0735294,0,80,unavailable,0.9,0.2,37.2,"spleen: 37.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187268,FAM9C,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.6923% (minimum 95%, Missing); adrenal gland: 55.5556% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 71.4286% (minimum 99%, Missing); bone marrow: 93.7500% (minimum 99%, Missing); cerebellum: 62.5000% (minimum 99%, Missing); cerebral cortex: 57.6923% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 93.7500% (minimum 99%, Missing); esophagus: 68.1818% (minimum 97%, Missing); heart muscle: 51.7241% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 65.2174% (minimum 99%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 65.2174% (minimum 99%, Missing); lymph node: 83.3333% (minimum 97%, Missing); midbrain: 78.9474% (minimum 99%, Missing); pancreas: 44.1176% (minimum 99%, Missing); parathyroid gland: 68.1818% (minimum 97%, Missing); pituitary gland: 51.7241% (minimum 99%, Missing); rectum: 71.4286% (minimum 97%, Missing); retina: 55.5556% (minimum 99%, Missing); salivary gland: 51.7241% (minimum 97%, Missing); skeletal muscle: 78.9474% (minimum 99%, Missing); skin: 45.4545% (minimum 95%, Missing); small intestine: 78.9474% (minimum 99%, Missing); smooth muscle: 53.5714% (minimum 99%, Missing); spinal cord: 71.4286% (minimum 99%, Missing); spleen: 65.2174% (minimum 95%, Missing); stomach: 68.1818% (minimum 97%, Missing); thymus: 93.7500% (minimum 95%, Missing); thyroid gland: 65.2174% (minimum 95%, Missing); tongue: 68.1818% (minimum 97%, Missing); urinary bladder: 65.2174% (minimum 97%, Missing)",-0.495455,-0.452759,-0.548824,0,80,unavailable,1.9,1.4,1.8,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187372,PCDHB13,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.6923% (minimum 65%, Missing); adrenal gland: 55.5556% (minimum 75%, Missing); basal ganglia: 71.4286% (minimum 75%, Missing); cerebellum: 62.5000% (minimum 75%, Missing); cerebral cortex: 57.6923% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); esophagus: 68.1818% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); kidney: 65.2174% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); pancreas: 44.1176% (minimum 75%, Missing); parathyroid gland: 68.1818% (minimum 70%, Missing); pituitary gland: 51.7241% (minimum 75%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 51.7241% (minimum 70%, Missing); skin: 45.4545% (minimum 65%, Missing); smooth muscle: 53.5714% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing); stomach: 68.1818% (minimum 70%, Missing); tongue: 68.1818% (minimum 70%, Missing); urinary bladder: 65.2174% (minimum 70%, Missing)",-0.195455,-0.182759,-0.308824,0,80,unavailable,1.9,1.4,1.8,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187372,PCDHB13,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.6923% (minimum 65%, Missing); adrenal gland: 55.5556% (minimum 75%, Missing); basal ganglia: 71.4286% (minimum 75%, Missing); cerebellum: 62.5000% (minimum 75%, Missing); cerebral cortex: 57.6923% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); esophagus: 68.1818% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); kidney: 65.2174% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); pancreas: 44.1176% (minimum 75%, Missing); parathyroid gland: 68.1818% (minimum 70%, Missing); pituitary gland: 51.7241% (minimum 75%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 51.7241% (minimum 70%, Missing); skin: 45.4545% (minimum 65%, Missing); smooth muscle: 53.5714% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing); stomach: 68.1818% (minimum 70%, Missing); tongue: 68.1818% (minimum 70%, Missing); urinary bladder: 65.2174% (minimum 70%, Missing)",-0.195455,-0.182759,-0.308824,0,80,unavailable,1.9,1.4,1.8,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187372,PCDHB13,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.6923% (minimum 65%, Missing); adrenal gland: 55.5556% (minimum 75%, Missing); basal ganglia: 71.4286% (minimum 75%, Missing); cerebellum: 62.5000% (minimum 75%, Missing); cerebral cortex: 57.6923% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); esophagus: 68.1818% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); kidney: 65.2174% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); pancreas: 44.1176% (minimum 75%, Missing); parathyroid gland: 68.1818% (minimum 70%, Missing); pituitary gland: 51.7241% (minimum 75%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 51.7241% (minimum 70%, Missing); skin: 45.4545% (minimum 65%, Missing); smooth muscle: 53.5714% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing); stomach: 68.1818% (minimum 70%, Missing); tongue: 68.1818% (minimum 70%, Missing); urinary bladder: 65.2174% (minimum 70%, Missing)",-0.195455,-0.182759,-0.308824,0,80,unavailable,1.9,1.4,1.8,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187372,PCDHB13,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.6923% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 55.5556% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.4286% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.5000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.6923% (minimum 75%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 70%, Baseline (adaptation disabled)); esophagus: 68.1818% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 51.7241% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.2174% (minimum 75%, Baseline (adaptation disabled)); lung: 65.2174% (minimum 75%, Baseline (adaptation disabled)); pancreas: 44.1176% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 68.1818% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 51.7241% (minimum 75%, Baseline (adaptation disabled)); retina: 55.5556% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.7241% (minimum 70%, Baseline (adaptation disabled)); skin: 45.4545% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 53.5714% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.4286% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.1818% (minimum 70%, Baseline (adaptation disabled)); tongue: 68.1818% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.2174% (minimum 70%, Baseline (adaptation disabled))",-0.195455,-0.182759,-0.308824,0,80,unavailable,1.9,1.4,1.8,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187372,PCDHB13,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;family_exclusion,True,True,True,"choroid plexus: 90.9091% (minimum 99%, Missing); liver: 90.9091% (minimum 95%, Enhanced); skeletal muscle: 90.9091% (minimum 95%, Enhanced)",0.05,0.03,-0.0809091,0,1,partial,0.1,0,0,,,54,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187475,H1-6,admission_only,False,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.35,0.3,0.159091,0,1,partial,0.1,0,0,,,54,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187475,H1-6,selectivity_revised,False,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.35,0.3,0.159091,0,1,partial,0.1,0,0,,,54,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187475,H1-6,grid_revised,False,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.35,0.3,0.159091,0,1,partial,0.1,0,0,,,54,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187475,H1-6,current_adaptive,False,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.35,0.3,0.159091,0,1,partial,0.1,0,0,,,54,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187475,H1-6,current_fixed,False,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0456% (minimum 95%, Missing); adrenal gland: 78.9955% (minimum 99%, Missing); amygdala: 94.5002% (minimum 99%, Missing); basal ganglia: 94.6606% (minimum 99%, Missing); cerebellum: 97.4204% (minimum 99%, Missing); cerebral cortex: 95.2075% (minimum 99%, Missing); choroid plexus: 95.8620% (minimum 99%, Missing); colon: 83.2587% (minimum 97%, Missing); duodenum: 97.4466% (minimum 99%, Missing); esophagus: 94.3404% (minimum 97%, Uncertain); heart muscle: 73.5918% (minimum 99%, Missing); hippocampal formation: 95.2325% (minimum 99%, Missing); hypothalamus: 90.2539% (minimum 99%, Missing); kidney: 76.7708% (minimum 99%, Missing); liver: 80.5756% (minimum 99%, Missing); lung: 66.4559% (minimum 99%, Missing); midbrain: 91.8081% (minimum 99%, Missing); pancreas: 92.4990% (minimum 99%, Missing); pituitary gland: 85.4869% (minimum 99%, Missing); skeletal muscle: 87.1410% (minimum 99%, Uncertain); skin: 88.5240% (minimum 95%, Missing); small intestine: 85.1556% (minimum 99%, Missing); smooth muscle: 96.3588% (minimum 99%, Missing); spinal cord: 94.0589% (minimum 99%, Missing); spleen: 93.1766% (minimum 95%, Missing); stomach: 75.7443% (minimum 97%, Missing); thyroid gland: 86.2393% (minimum 95%, Missing); urinary bladder: 80.9625% (minimum 97%, Missing)",-0.339544,-0.212557,-0.325441,0,4,partial,366,232.2,462.7,"adipose tissue: 462.7 nTPM (manageable, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 2); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 2); colon: 145.8 nTPM (protected, limit 2); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (manageable, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); skin: 94 nTPM (manageable, limit 5); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); pancreas: 58.8 nTPM (vital, limit 1); spleen: 53.1 nTPM (manageable, limit 5); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 2); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 2); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); rectum: 8.1 nTPM (protected, limit 2); lymph node: 6.6 nTPM (protected, limit 2); bone marrow: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187479,C11orf96,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0456% (minimum 65%, Missing); heart muscle: 73.5918% (minimum 75%, Missing); lung: 66.4559% (minimum 75%, Missing)",-0.0395437,0.0574428,-0.0854413,0,4,partial,366,232.2,462.7,"adipose tissue: 462.7 nTPM (manageable, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 2); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 2); colon: 145.8 nTPM (protected, limit 2); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (manageable, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); skin: 94 nTPM (manageable, limit 5); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); pancreas: 58.8 nTPM (vital, limit 1); spleen: 53.1 nTPM (manageable, limit 5); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 2); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 2); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); rectum: 8.1 nTPM (protected, limit 2); lymph node: 6.6 nTPM (protected, limit 2); bone marrow: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187479,C11orf96,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0456% (minimum 65%, Missing); heart muscle: 73.5918% (minimum 75%, Missing); lung: 66.4559% (minimum 75%, Missing)",-0.0395437,0.0574428,-0.0854413,0,4,partial,366,232.2,462.7,"adipose tissue: 462.7 nTPM (manageable, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 3); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 3); colon: 145.8 nTPM (protected, limit 3); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (manageable, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); skin: 94 nTPM (manageable, limit 5); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); pancreas: 58.8 nTPM (vital, limit 1); spleen: 53.1 nTPM (manageable, limit 5); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 3); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 3); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 3); rectum: 8.1 nTPM (protected, limit 3); lymph node: 6.6 nTPM (protected, limit 3); bone marrow: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187479,C11orf96,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0456% (minimum 65%, Missing); heart muscle: 73.5918% (minimum 75%, Missing); lung: 66.4559% (minimum 75%, Missing)",-0.0395437,0.0574428,-0.0854413,0,4,partial,366,232.2,462.7,"adipose tissue: 462.7 nTPM (manageable, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 3); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 3); colon: 145.8 nTPM (protected, limit 3); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (manageable, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); skin: 94 nTPM (manageable, limit 5); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); pancreas: 58.8 nTPM (vital, limit 1); spleen: 53.1 nTPM (manageable, limit 5); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 3); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 3); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 3); rectum: 8.1 nTPM (protected, limit 3); lymph node: 6.6 nTPM (protected, limit 3); bone marrow: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187479,C11orf96,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0456% (minimum 65%, Baseline (adaptation disabled)); heart muscle: 73.5918% (minimum 75%, Baseline (adaptation disabled)); lung: 66.4559% (minimum 75%, Baseline (adaptation disabled))",-0.0395437,0.0574428,-0.0854413,0,4,partial,366,232.2,462.7,"adipose tissue: 462.7 nTPM (manageable, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 3); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 3); colon: 145.8 nTPM (protected, limit 3); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (manageable, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); skin: 94 nTPM (manageable, limit 5); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); pancreas: 58.8 nTPM (vital, limit 1); spleen: 53.1 nTPM (manageable, limit 5); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 3); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 3); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 3); rectum: 8.1 nTPM (protected, limit 3); lymph node: 6.6 nTPM (protected, limit 3); bone marrow: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187479,C11orf96,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.00767442,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187516,H2AP,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247674,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187516,H2AP,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247674,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187516,H2AP,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247674,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187516,H2AP,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34536,0.3,0.247674,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187516,H2AP,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 83.3333% (minimum 95%, Enhanced); heart muscle: 71.4286% (minimum 95%, Enhanced); pancreas: 31.2500% (minimum 95%, Enhanced); salivary gland: 0.0466% (minimum 97%, Missing)",0.05,-0.969534,-0.6375,0,2,partial,1.1,1071.7,0,"salivary gland: 1071.7 nTPM (protected, limit 2)",salivary gland / glandular cells: High (Enhanced),54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; salivary gland / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187533,PRR27,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 31.2500% (minimum 60%, Enhanced); salivary gland: 0.0466% (minimum 70%, Missing)",0.35,-0.699534,-0.2875,0,2,partial,1.1,1071.7,0,"salivary gland: 1071.7 nTPM (protected, limit 2)",salivary gland / glandular cells: High (Enhanced),54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; salivary gland / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187533,PRR27,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 31.2500% (minimum 60%, Enhanced); salivary gland: 0.0466% (minimum 70%, Missing)",0.35,-0.699534,-0.2875,0,2,partial,1.1,1071.7,0,"salivary gland: 1071.7 nTPM (protected, limit 3)",salivary gland / glandular cells: High (Enhanced),54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; salivary gland / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187533,PRR27,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 31.2500% (minimum 60%, Enhanced); salivary gland: 0.0466% (minimum 70%, Missing)",0.35,-0.699534,-0.2875,0,2,partial,1.1,1071.7,0,"salivary gland: 1071.7 nTPM (protected, limit 3)",salivary gland / glandular cells: High (Enhanced),54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; salivary gland / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187533,PRR27,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"heart muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); pancreas: 31.2500% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 0.0466% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.699534,-0.4375,0,2,partial,1.1,1071.7,0,"salivary gland: 1071.7 nTPM (protected, limit 3); pancreas: 1.1 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; salivary gland / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187533,PRR27,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187537,POTEG,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187537,POTEG,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187537,POTEG,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187537,POTEG,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187537,POTEG,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.8750% (minimum 99%, Missing); duodenum: 93.9394% (minimum 99%, Missing); lung: 86.1111% (minimum 99%, Missing); retina: 96.8750% (minimum 99%, Missing); stomach: 96.8750% (minimum 97%, Missing)",0.01875,-0.00125,-0.128889,0,80,unavailable,0.5,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187569,DPPA3,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31875,0.26875,0.111111,0,80,unavailable,0.5,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187569,DPPA3,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31875,0.26875,0.111111,0,80,unavailable,0.5,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187569,DPPA3,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31875,0.26875,0.111111,0,80,unavailable,0.5,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187569,DPPA3,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.31875,0.26875,0.111111,0,80,unavailable,0.5,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187569,DPPA3,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.05,0.0286523,0.00730821,0,5,partial,0.4,0.1,0,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node / germinal center cells; skin 1 / fibroblasts; skin 2 / epidermal cells; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187581,COX8C,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.298652,0.247308,0,5,partial,0.4,0.1,0,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node / germinal center cells; skin 1 / fibroblasts; skin 2 / epidermal cells; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187581,COX8C,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.298652,0.247308,0,5,partial,0.4,0.1,0,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node / germinal center cells; skin 1 / fibroblasts; skin 2 / epidermal cells; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187581,COX8C,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.298652,0.247308,0,5,partial,0.4,0.1,0,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node / germinal center cells; skin 1 / fibroblasts; skin 2 / epidermal cells; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187581,COX8C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.298652,0.244631,0,5,partial,0.4,0.1,0,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node / germinal center cells; skin 1 / fibroblasts; skin 2 / epidermal cells; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187581,COX8C,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 74.3961% (minimum 95%, Missing); adrenal gland: 66.9565% (minimum 99%, Missing); amygdala: 72.9858% (minimum 99%, Missing); basal ganglia: 73.6842% (minimum 99%, Missing); bone marrow: 79.7927% (minimum 99%, Missing); cerebellum: 69.6833% (minimum 99%, Missing); cerebral cortex: 65.5319% (minimum 99%, Missing); choroid plexus: 67.5439% (minimum 99%, Missing); colon: 73.3333% (minimum 97%, Missing); duodenum: 80.6283% (minimum 99%, Missing); esophagus: 61.3546% (minimum 97%, Missing); heart muscle: 50.6579% (minimum 99%, Missing); hippocampal formation: 70.6422% (minimum 99%, Missing); hypothalamus: 73.3333% (minimum 99%, Missing); kidney: 67.2489% (minimum 99%, Missing); liver: 79.3814% (minimum 99%, Missing); lung: 75.8621% (minimum 99%, Missing); lymph node: 64.1667% (minimum 97%, Missing); midbrain: 67.5439% (minimum 99%, Missing); pancreas: 79.7927% (minimum 99%, Missing); parathyroid gland: 52.5597% (minimum 97%, Missing); pituitary gland: 73.6842% (minimum 99%, Missing); rectum: 77.0000% (minimum 97%, Missing); retina: 57.4627% (minimum 99%, Missing); salivary gland: 76.2376% (minimum 97%, Missing); skeletal muscle: 79.3814% (minimum 99%, Missing); skin: 73.3333% (minimum 95%, Missing); small intestine: 80.6283% (minimum 99%, Missing); smooth muscle: 59.2308% (minimum 99%, Missing); spinal cord: 61.6000% (minimum 99%, Missing); spleen: 73.6842% (minimum 95%, Missing); stomach: 75.1220% (minimum 97%, Missing); thymus: 55.0000% (minimum 95%, Missing); thyroid gland: 60.3922% (minimum 95%, Missing); tongue: 62.0968% (minimum 97%, Missing); urinary bladder: 64.1667% (minimum 97%, Missing)",-0.4,-0.444403,-0.483421,0,80,unavailable,15,13.9,12.6,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 2); thymus: 12.6 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 2); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); lymph node: 8.6 nTPM (protected, limit 2); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.5 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); stomach: 5.1 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187607,ZNF286A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 66.9565% (minimum 75%, Missing); amygdala: 72.9858% (minimum 75%, Missing); basal ganglia: 73.6842% (minimum 75%, Missing); cerebellum: 69.6833% (minimum 75%, Missing); cerebral cortex: 65.5319% (minimum 75%, Missing); choroid plexus: 67.5439% (minimum 75%, Missing); esophagus: 61.3546% (minimum 70%, Missing); heart muscle: 50.6579% (minimum 75%, Missing); hippocampal formation: 70.6422% (minimum 75%, Missing); hypothalamus: 73.3333% (minimum 75%, Missing); kidney: 67.2489% (minimum 75%, Missing); lymph node: 64.1667% (minimum 70%, Missing); midbrain: 67.5439% (minimum 75%, Missing); parathyroid gland: 52.5597% (minimum 70%, Missing); pituitary gland: 73.6842% (minimum 75%, Missing); retina: 57.4627% (minimum 75%, Missing); smooth muscle: 59.2308% (minimum 75%, Missing); spinal cord: 61.6000% (minimum 75%, Missing); thymus: 55.0000% (minimum 65%, Missing); thyroid gland: 60.3922% (minimum 65%, Missing); tongue: 62.0968% (minimum 70%, Missing); urinary bladder: 64.1667% (minimum 70%, Missing)",-0.1,-0.174403,-0.243421,0,80,unavailable,15,13.9,12.6,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 2); thymus: 12.6 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 2); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); lymph node: 8.6 nTPM (protected, limit 2); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.5 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); stomach: 5.1 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187607,ZNF286A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 66.9565% (minimum 75%, Missing); amygdala: 72.9858% (minimum 75%, Missing); basal ganglia: 73.6842% (minimum 75%, Missing); cerebellum: 69.6833% (minimum 75%, Missing); cerebral cortex: 65.5319% (minimum 75%, Missing); choroid plexus: 67.5439% (minimum 75%, Missing); esophagus: 61.3546% (minimum 70%, Missing); heart muscle: 50.6579% (minimum 75%, Missing); hippocampal formation: 70.6422% (minimum 75%, Missing); hypothalamus: 73.3333% (minimum 75%, Missing); kidney: 67.2489% (minimum 75%, Missing); lymph node: 64.1667% (minimum 70%, Missing); midbrain: 67.5439% (minimum 75%, Missing); parathyroid gland: 52.5597% (minimum 70%, Missing); pituitary gland: 73.6842% (minimum 75%, Missing); retina: 57.4627% (minimum 75%, Missing); smooth muscle: 59.2308% (minimum 75%, Missing); spinal cord: 61.6000% (minimum 75%, Missing); thymus: 55.0000% (minimum 65%, Missing); thyroid gland: 60.3922% (minimum 65%, Missing); tongue: 62.0968% (minimum 70%, Missing); urinary bladder: 64.1667% (minimum 70%, Missing)",-0.1,-0.174403,-0.243421,0,80,unavailable,15,13.9,12.6,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 3); thymus: 12.6 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 3); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 3); urinary bladder: 8.6 nTPM (protected, limit 3); lymph node: 8.6 nTPM (protected, limit 3); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.5 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); stomach: 5.1 nTPM (protected, limit 3); lung: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); liver: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187607,ZNF286A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 66.9565% (minimum 75%, Missing); amygdala: 72.9858% (minimum 75%, Missing); basal ganglia: 73.6842% (minimum 75%, Missing); cerebellum: 69.6833% (minimum 75%, Missing); cerebral cortex: 65.5319% (minimum 75%, Missing); choroid plexus: 67.5439% (minimum 75%, Missing); esophagus: 61.3546% (minimum 70%, Missing); heart muscle: 50.6579% (minimum 75%, Missing); hippocampal formation: 70.6422% (minimum 75%, Missing); hypothalamus: 73.3333% (minimum 75%, Missing); kidney: 67.2489% (minimum 75%, Missing); lymph node: 64.1667% (minimum 70%, Missing); midbrain: 67.5439% (minimum 75%, Missing); parathyroid gland: 52.5597% (minimum 70%, Missing); pituitary gland: 73.6842% (minimum 75%, Missing); retina: 57.4627% (minimum 75%, Missing); smooth muscle: 59.2308% (minimum 75%, Missing); spinal cord: 61.6000% (minimum 75%, Missing); thymus: 55.0000% (minimum 65%, Missing); thyroid gland: 60.3922% (minimum 65%, Missing); tongue: 62.0968% (minimum 70%, Missing); urinary bladder: 64.1667% (minimum 70%, Missing)",-0.1,-0.174403,-0.243421,0,80,unavailable,15,13.9,12.6,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 3); thymus: 12.6 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 3); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 3); urinary bladder: 8.6 nTPM (protected, limit 3); lymph node: 8.6 nTPM (protected, limit 3); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.5 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); stomach: 5.1 nTPM (protected, limit 3); lung: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); liver: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187607,ZNF286A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 66.9565% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.9858% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.6842% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 69.6833% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.5319% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.5439% (minimum 75%, Baseline (adaptation disabled)); esophagus: 61.3546% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 50.6579% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.6422% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.3333% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.2489% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.1667% (minimum 70%, Baseline (adaptation disabled)); midbrain: 67.5439% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.5597% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 73.6842% (minimum 75%, Baseline (adaptation disabled)); retina: 57.4627% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.2308% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.6000% (minimum 75%, Baseline (adaptation disabled)); thymus: 55.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 60.3922% (minimum 65%, Baseline (adaptation disabled)); tongue: 62.0968% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 64.1667% (minimum 70%, Baseline (adaptation disabled))",-0.1,-0.174403,-0.243421,0,80,unavailable,15,13.9,12.6,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 3); thymus: 12.6 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 3); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 3); urinary bladder: 8.6 nTPM (protected, limit 3); lymph node: 8.6 nTPM (protected, limit 3); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.5 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); stomach: 5.1 nTPM (protected, limit 3); lung: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); liver: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187607,ZNF286A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.9614% (minimum 99%, Missing); amygdala: 89.7959% (minimum 99%, Missing); basal ganglia: 85.3731% (minimum 99%, Missing); cerebellum: 94.5455% (minimum 98%, Approved); cerebral cortex: 87.1951% (minimum 99%, Missing); choroid plexus: 92.1095% (minimum 99%, Missing); colon: 93.6170% (minimum 97%, Missing); duodenum: 98.7910% (minimum 99%, Missing); esophagus: 94.8590% (minimum 97%, Missing); heart muscle: 94.0789% (minimum 99%, Missing); hippocampal formation: 89.5149% (minimum 99%, Missing); hypothalamus: 87.7301% (minimum 99%, Missing); kidney: 87.4618% (minimum 99%, Missing); liver: 95.6522% (minimum 99%, Missing); lung: 95.4925% (minimum 99%, Missing); midbrain: 91.9614% (minimum 99%, Missing); pancreas: 95.3333% (minimum 99%, Missing); parathyroid gland: 96.7851% (minimum 97%, Missing); pituitary gland: 89.3750% (minimum 99%, Missing); retina: 95.6522% (minimum 99%, Missing); salivary gland: 95.0166% (minimum 97%, Missing); skeletal muscle: 92.7066% (minimum 98%, Approved); small intestine: 95.9732% (minimum 99%, Missing); spinal cord: 94.5455% (minimum 99%, Missing); stomach: 95.1747% (minimum 97%, Missing); thyroid gland: 89.5149% (minimum 95%, Missing); urinary bladder: 95.6522% (minimum 97%, Missing)",-0.0548513,-0.0338298,-0.136269,0,3,partial,9.8,3.9,6.7,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 2); colon: 3.9 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 2); esophagus: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187624,LIAT1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.245149,0.23617,0.103731,0,3,partial,9.8,3.9,6.7,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 2); colon: 3.9 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 2); esophagus: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187624,LIAT1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.245149,0.23617,0.103731,0,3,partial,9.8,3.9,6.7,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 2); colon: 3.9 nTPM (protected, limit 3); heart muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187624,LIAT1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.245149,0.23617,0.103731,0,3,partial,9.8,3.9,6.7,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 2); colon: 3.9 nTPM (protected, limit 3); heart muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187624,LIAT1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.245149,0.23617,0.103731,0,3,partial,9.8,3.9,6.7,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 3); heart muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187624,LIAT1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"colon: 95.3552% (minimum 97%, Missing); duodenum: 98.3099% (minimum 99%, Missing); rectum: 96.9444% (minimum 97%, Missing); small intestine: 98.0337% (minimum 99%, Missing)",0.05,-0.0164481,-0.00966292,0,80,unavailable,0.7,1.7,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187658,C5orf52,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.253552,0.230337,0,80,unavailable,0.7,1.7,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187658,C5orf52,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.253552,0.230337,0,80,unavailable,0.7,1.7,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187658,C5orf52,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.253552,0.230337,0,80,unavailable,0.7,1.7,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187658,C5orf52,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.253552,0.230337,0,80,unavailable,0.7,1.7,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187658,C5orf52,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 95.0000% (minimum 99%, Missing); basal ganglia: 93.4426% (minimum 99%, Missing); cerebellum: 78.0822% (minimum 95%, Enhanced); choroid plexus: 91.9355% (minimum 99%, Missing); hippocampal formation: 95.0000% (minimum 99%, Missing); hypothalamus: 95.0000% (minimum 99%, Missing); midbrain: 96.6102% (minimum 99%, Missing); pituitary gland: 85.0746% (minimum 99%, Missing); retina: 96.6102% (minimum 99%, Missing); spinal cord: 96.6102% (minimum 99%, Missing)",0.05,0.03,-0.169178,0,2,partial,1.6,0.1,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187690,EZHIP,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.100746,0,2,partial,1.6,0.1,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187690,EZHIP,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.100746,0,2,partial,1.6,0.1,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187690,EZHIP,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.100746,0,2,partial,1.6,0.1,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187690,EZHIP,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.269355,0.282759,0.0308219,0,2,partial,1.6,0.1,0.5,"cerebellum: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187690,EZHIP,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.9868% (minimum 99%, Missing); basal ganglia: 95.9032% (minimum 99%, Missing); bone marrow: 92.1288% (minimum 95%, Enhanced); choroid plexus: 66.3660% (minimum 99%, Missing); hippocampal formation: 95.7249% (minimum 99%, Missing); hypothalamus: 95.3704% (minimum 99%, Missing); lung: 94.4954% (minimum 95%, Enhanced); pituitary gland: 97.9087% (minimum 99%, Missing); small intestine: 94.8435% (minimum 95%, Enhanced); spinal cord: 98.8484% (minimum 99%, Missing)",0.05,0.03,-0.32634,0,6,partial,26.1,2,1.2,"choroid plexus: 26.1 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187726,DNAJB13,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 66.3660% (minimum 75%, Missing)",0.35,0.3,-0.0863402,0,6,partial,26.1,2,1.2,"choroid plexus: 26.1 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187726,DNAJB13,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 66.3660% (minimum 75%, Missing)",0.35,0.3,-0.0863402,0,6,partial,26.1,2,1.2,"choroid plexus: 26.1 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187726,DNAJB13,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 66.3660% (minimum 75%, Missing)",0.35,0.3,-0.0863402,0,6,partial,26.1,2,1.2,"choroid plexus: 26.1 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187726,DNAJB13,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 66.3660% (minimum 75%, Baseline (adaptation disabled))",0.32723,0.262617,-0.0863402,0,6,partial,26.1,2,1.2,"choroid plexus: 26.1 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187726,DNAJB13,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.7761% (minimum 95%, Missing); adrenal gland: 66.3900% (minimum 99%, Missing); amygdala: 86.4865% (minimum 99%, Missing); basal ganglia: 84.6561% (minimum 99%, Missing); bone marrow: 83.3333% (minimum 99%, Missing); cerebellum: 71.1111% (minimum 99%, Missing); cerebral cortex: 84.2105% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 54.0541% (minimum 97%, Missing); duodenum: 70.1754% (minimum 99%, Missing); esophagus: 69.5652% (minimum 97%, Missing); heart muscle: 72.7273% (minimum 99%, Missing); hippocampal formation: 84.6561% (minimum 99%, Missing); hypothalamus: 83.7696% (minimum 99%, Missing); kidney: 56.1404% (minimum 99%, Missing); liver: 66.9456% (minimum 99%, Missing); lung: 70.4846% (minimum 99%, Missing); lymph node: 75.1174% (minimum 97%, Missing); midbrain: 85.1064% (minimum 99%, Missing); pancreas: 66.1157% (minimum 99%, Missing); parathyroid gland: 83.7696% (minimum 97%, Missing); pituitary gland: 85.5615% (minimum 99%, Missing); rectum: 64.7773% (minimum 97%, Missing); retina: 85.1064% (minimum 99%, Missing); salivary gland: 74.4186% (minimum 97%, Missing); skeletal muscle: 49.2308% (minimum 99%, Missing); skin: 66.1157% (minimum 95%, Missing); small intestine: 57.5540% (minimum 99%, Missing); smooth muscle: 72.0721% (minimum 99%, Missing); spinal cord: 81.2183% (minimum 99%, Missing); spleen: 70.4846% (minimum 95%, Missing); stomach: 64.7773% (minimum 97%, Missing); thymus: 75.1174% (minimum 95%, Missing); thyroid gland: 78.0488% (minimum 95%, Missing); tongue: 72.0721% (minimum 97%, Missing); urinary bladder: 61.3027% (minimum 97%, Missing)",-0.332239,-0.429459,-0.497692,0,1,partial,16.5,13.6,9.9,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 2); adipose tissue: 9.9 nTPM (manageable, limit 5); rectum: 8.7 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); skin: 8.2 nTPM (manageable, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 2); duodenum: 6.8 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); smooth muscle: 6.2 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187736,NHEJ1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.7761% (minimum 65%, Missing); adrenal gland: 66.3900% (minimum 75%, Missing); cerebellum: 71.1111% (minimum 75%, Missing); colon: 54.0541% (minimum 70%, Missing); duodenum: 70.1754% (minimum 75%, Missing); esophagus: 69.5652% (minimum 70%, Missing); heart muscle: 72.7273% (minimum 75%, Missing); kidney: 56.1404% (minimum 75%, Missing); liver: 66.9456% (minimum 75%, Missing); lung: 70.4846% (minimum 75%, Missing); pancreas: 66.1157% (minimum 75%, Missing); rectum: 64.7773% (minimum 70%, Missing); skeletal muscle: 49.2308% (minimum 75%, Missing); small intestine: 57.5540% (minimum 75%, Missing); smooth muscle: 72.0721% (minimum 75%, Missing); stomach: 64.7773% (minimum 70%, Missing); urinary bladder: 61.3027% (minimum 70%, Missing)",-0.0322394,-0.159459,-0.257692,0,1,partial,16.5,13.6,9.9,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 2); adipose tissue: 9.9 nTPM (manageable, limit 5); rectum: 8.7 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); skin: 8.2 nTPM (manageable, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 2); duodenum: 6.8 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); smooth muscle: 6.2 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187736,NHEJ1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.7761% (minimum 65%, Missing); adrenal gland: 66.3900% (minimum 75%, Missing); cerebellum: 71.1111% (minimum 75%, Missing); colon: 54.0541% (minimum 70%, Missing); duodenum: 70.1754% (minimum 75%, Missing); esophagus: 69.5652% (minimum 70%, Missing); heart muscle: 72.7273% (minimum 75%, Missing); kidney: 56.1404% (minimum 75%, Missing); liver: 66.9456% (minimum 75%, Missing); lung: 70.4846% (minimum 75%, Missing); pancreas: 66.1157% (minimum 75%, Missing); rectum: 64.7773% (minimum 70%, Missing); skeletal muscle: 49.2308% (minimum 75%, Missing); small intestine: 57.5540% (minimum 75%, Missing); smooth muscle: 72.0721% (minimum 75%, Missing); stomach: 64.7773% (minimum 70%, Missing); urinary bladder: 61.3027% (minimum 70%, Missing)",-0.0322394,-0.159459,-0.257692,0,1,partial,16.5,13.6,9.9,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 3); adipose tissue: 9.9 nTPM (manageable, limit 5); rectum: 8.7 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); skin: 8.2 nTPM (manageable, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 3); duodenum: 6.8 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); smooth muscle: 6.2 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187736,NHEJ1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.7761% (minimum 65%, Missing); adrenal gland: 66.3900% (minimum 75%, Missing); cerebellum: 71.1111% (minimum 75%, Missing); colon: 54.0541% (minimum 70%, Missing); duodenum: 70.1754% (minimum 75%, Missing); esophagus: 69.5652% (minimum 70%, Missing); heart muscle: 72.7273% (minimum 75%, Missing); kidney: 56.1404% (minimum 75%, Missing); liver: 66.9456% (minimum 75%, Missing); lung: 70.4846% (minimum 75%, Missing); pancreas: 66.1157% (minimum 75%, Missing); rectum: 64.7773% (minimum 70%, Missing); skeletal muscle: 49.2308% (minimum 75%, Missing); small intestine: 57.5540% (minimum 75%, Missing); smooth muscle: 72.0721% (minimum 75%, Missing); stomach: 64.7773% (minimum 70%, Missing); urinary bladder: 61.3027% (minimum 70%, Missing)",-0.0322394,-0.159459,-0.257692,0,1,partial,16.5,13.6,9.9,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 3); adipose tissue: 9.9 nTPM (manageable, limit 5); rectum: 8.7 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); skin: 8.2 nTPM (manageable, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 3); duodenum: 6.8 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); smooth muscle: 6.2 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187736,NHEJ1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.7761% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 66.3900% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 71.1111% (minimum 75%, Baseline (adaptation disabled)); colon: 54.0541% (minimum 70%, Baseline (adaptation disabled)); duodenum: 70.1754% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.5652% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 72.7273% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.1404% (minimum 75%, Baseline (adaptation disabled)); liver: 66.9456% (minimum 75%, Baseline (adaptation disabled)); lung: 70.4846% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.1157% (minimum 75%, Baseline (adaptation disabled)); rectum: 64.7773% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 49.2308% (minimum 75%, Baseline (adaptation disabled)); small intestine: 57.5540% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.0721% (minimum 75%, Baseline (adaptation disabled)); stomach: 64.7773% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.3027% (minimum 70%, Baseline (adaptation disabled))",-0.0322394,-0.159459,-0.257692,0,1,partial,16.5,13.6,9.9,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 3); adipose tissue: 9.9 nTPM (manageable, limit 5); rectum: 8.7 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); skin: 8.2 nTPM (manageable, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 3); duodenum: 6.8 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); smooth muscle: 6.2 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187736,NHEJ1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Missing); adrenal gland: 91.7031% (minimum 99%, Missing); amygdala: 92.1053% (minimum 99%, Missing); basal ganglia: 90.9091% (minimum 99%, Missing); bone marrow: 65.0155% (minimum 99%, Missing); cerebellum: 80.1527% (minimum 99%, Missing); cerebral cortex: 86.4198% (minimum 99%, Missing); choroid plexus: 94.1704% (minimum 99%, Missing); colon: 84.0000% (minimum 97%, Missing); duodenum: 86.0656% (minimum 99%, Missing); esophagus: 76.6423% (minimum 97%, Missing); heart muscle: 93.3333% (minimum 99%, Missing); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 94.5946% (minimum 99%, Missing); kidney: 88.2353% (minimum 99%, Missing); liver: 78.0669% (minimum 99%, Missing); lung: 86.7769% (minimum 99%, Missing); lymph node: 73.1707% (minimum 97%, Missing); midbrain: 95.0226% (minimum 99%, Missing); pancreas: 92.1053% (minimum 99%, Missing); parathyroid gland: 96.7742% (minimum 97%, Missing); pituitary gland: 91.7031% (minimum 99%, Missing); rectum: 88.6076% (minimum 97%, Missing); retina: 97.6744% (minimum 99%, Missing); salivary gland: 91.3043% (minimum 97%, Missing); skeletal muscle: 96.7742% (minimum 99%, Missing); skin: 87.1369% (minimum 95%, Missing); small intestine: 79.2453% (minimum 99%, Missing); smooth muscle: 94.1704% (minimum 99%, Missing); spinal cord: 94.5946% (minimum 99%, Missing); spleen: 76.3636% (minimum 95%, Missing); stomach: 89.3617% (minimum 97%, Missing); thymus: 82.3529% (minimum 95%, Missing); thyroid gland: 92.9204% (minimum 95%, Missing); urinary bladder: 93.7500% (minimum 97%, Missing)",-0.186364,-0.238293,-0.339845,0,80,unavailable,11.3,7.7,6.5,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 2); spleen: 6.5 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 2); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187741,FANCA,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 65.0155% (minimum 75%, Missing)",0.113636,0.0317073,-0.0998452,0,80,unavailable,11.3,7.7,6.5,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 2); spleen: 6.5 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 2); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187741,FANCA,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 65.0155% (minimum 75%, Missing)",0.113636,0.0317073,-0.0998452,0,80,unavailable,11.3,7.7,6.5,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 3); spleen: 6.5 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 3); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187741,FANCA,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 65.0155% (minimum 75%, Missing)",0.113636,0.0317073,-0.0998452,0,80,unavailable,11.3,7.7,6.5,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 3); spleen: 6.5 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 3); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187741,FANCA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 65.0155% (minimum 75%, Baseline (adaptation disabled))",0.113636,0.0317073,-0.0998452,0,80,unavailable,11.3,7.7,6.5,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 3); spleen: 6.5 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 3); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187741,FANCA,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.0392% (minimum 99%, Missing); bone marrow: 89.2857% (minimum 99%, Missing); cerebral cortex: 98.5222% (minimum 99%, Missing); retina: 97.0874% (minimum 99%, Missing)",0.0352217,0.00560976,-0.0971429,0,80,unavailable,2.4,0.5,0.3,"bone marrow: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187753,C9orf153,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335222,0.27561,0.142857,0,80,unavailable,2.4,0.5,0.3,"bone marrow: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187753,C9orf153,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335222,0.27561,0.142857,0,80,unavailable,2.4,0.5,0.3,"bone marrow: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187753,C9orf153,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335222,0.27561,0.142857,0,80,unavailable,2.4,0.5,0.3,"bone marrow: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187753,C9orf153,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335222,0.27561,0.142857,0,80,unavailable,2.4,0.5,0.3,"bone marrow: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187753,C9orf153,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 98%, Approved); cerebral cortex: 33.3333% (minimum 98%, Approved); duodenum: 50.0000% (minimum 98%, Approved); esophagus: 25.0000% (minimum 95%, Approved); lung: 50.0000% (minimum 98%, Approved); lymph node: 50.0000% (minimum 95%, Approved); retina: 14.2857% (minimum 99%, Missing); salivary gland: 25.0000% (minimum 95%, Approved); skin: 25.0000% (minimum 90%, Approved); spleen: 50.0000% (minimum 90%, Approved); stomach: 50.0000% (minimum 95%, Approved)",-0.65,-0.7,-0.847143,0,2,partial,0.6,0.3,0.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187754,SSX7,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 70%, Approved); cerebral cortex: 33.3333% (minimum 70%, Approved); duodenum: 50.0000% (minimum 70%, Approved); esophagus: 25.0000% (minimum 65%, Approved); lung: 50.0000% (minimum 70%, Approved); lymph node: 50.0000% (minimum 65%, Approved); retina: 14.2857% (minimum 75%, Missing); salivary gland: 25.0000% (minimum 65%, Approved); skin: 25.0000% (minimum 60%, Approved); spleen: 50.0000% (minimum 60%, Approved); stomach: 50.0000% (minimum 65%, Approved)",-0.35,-0.4,-0.607143,0,2,partial,0.6,0.3,0.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187754,SSX7,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 70%, Approved); cerebral cortex: 33.3333% (minimum 70%, Approved); duodenum: 50.0000% (minimum 70%, Approved); esophagus: 25.0000% (minimum 65%, Approved); lung: 50.0000% (minimum 70%, Approved); lymph node: 50.0000% (minimum 65%, Approved); retina: 14.2857% (minimum 75%, Missing); salivary gland: 25.0000% (minimum 65%, Approved); skin: 25.0000% (minimum 60%, Approved); spleen: 50.0000% (minimum 60%, Approved); stomach: 50.0000% (minimum 65%, Approved)",-0.35,-0.4,-0.607143,0,2,partial,0.6,0.3,0.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187754,SSX7,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 70%, Approved); cerebral cortex: 33.3333% (minimum 70%, Approved); duodenum: 50.0000% (minimum 70%, Approved); esophagus: 25.0000% (minimum 65%, Approved); lung: 50.0000% (minimum 70%, Approved); lymph node: 50.0000% (minimum 65%, Approved); retina: 14.2857% (minimum 75%, Missing); salivary gland: 25.0000% (minimum 65%, Approved); skin: 25.0000% (minimum 60%, Approved); spleen: 50.0000% (minimum 60%, Approved); stomach: 50.0000% (minimum 65%, Approved)",-0.35,-0.4,-0.607143,0,2,partial,0.6,0.3,0.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187754,SSX7,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 33.3333% (minimum 75%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 25.0000% (minimum 70%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 14.2857% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 25.0000% (minimum 70%, Baseline (adaptation disabled)); skin: 25.0000% (minimum 65%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 70%, Baseline (adaptation disabled))",-0.4,-0.45,-0.607143,0,2,partial,0.6,0.3,0.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187754,SSX7,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.6816% (minimum 99%, Missing)",0.05,0.03,-0.0131839,0,4,partial,1.5,0.1,0.2,"retina: 1.5 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187772,LIN28B,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,"Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.226816,0,4,partial,1.5,0.1,0.2,"retina: 1.5 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187772,LIN28B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,"Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.226816,0,4,partial,1.5,0.1,0.2,"retina: 1.5 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187772,LIN28B,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,"Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.226816,0,4,partial,1.5,0.1,0.2,"retina: 1.5 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187772,LIN28B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,"Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346845,0.29842,0.226816,0,4,partial,1.5,0.1,0.2,"retina: 1.5 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187772,LIN28B,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,"Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 99%, Missing)",0.05,0.03,-0.297692,0,1,partial,2.4,0,0.4,"retina: 2.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187775,DNAH17,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 75%, Missing)",0.35,0.3,-0.0576923,0,1,partial,2.4,0,0.4,"retina: 2.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187775,DNAH17,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 75%, Missing)",0.35,0.3,-0.0576923,0,1,partial,2.4,0,0.4,"retina: 2.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187775,DNAH17,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 75%, Missing)",0.35,0.3,-0.0576923,0,1,partial,2.4,0,0.4,"retina: 2.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187775,DNAH17,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 75%, Baseline (adaptation disabled))",0.281034,0.3,-0.0576923,0,1,partial,2.4,0,0.4,"retina: 2.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187775,DNAH17,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.2683% (minimum 95%, Missing); adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 89.0411% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 66.3265% (minimum 99%, Missing); cerebellum: 82.2785% (minimum 99%, Missing); cerebral cortex: 86.6667% (minimum 99%, Missing); choroid plexus: 97.0149% (minimum 99%, Missing); colon: 86.6667% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); esophagus: 81.2500% (minimum 97%, Missing); heart muscle: 83.3333% (minimum 99%, Missing); hippocampal formation: 86.6667% (minimum 99%, Missing); hypothalamus: 86.6667% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 86.6667% (minimum 99%, Missing); lung: 84.4156% (minimum 99%, Missing); lymph node: 78.3133% (minimum 97%, Missing); midbrain: 87.8378% (minimum 99%, Missing); pancreas: 86.6667% (minimum 99%, Missing); parathyroid gland: 85.5263% (minimum 97%, Missing); pituitary gland: 89.0411% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 76.4706% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 80.2469% (minimum 99%, Missing); skin: 82.2785% (minimum 95%, Missing); small intestine: 84.4156% (minimum 99%, Missing); smooth muscle: 85.5263% (minimum 99%, Missing); spinal cord: 85.5263% (minimum 99%, Missing); spleen: 79.2683% (minimum 95%, Missing); stomach: 86.6667% (minimum 97%, Missing); thymus: 71.4286% (minimum 95%, Missing); thyroid gland: 86.6667% (minimum 95%, Missing); tongue: 82.2785% (minimum 97%, Missing); urinary bladder: 84.4156% (minimum 97%, Missing)",-0.235714,-0.186867,-0.326735,0,80,unavailable,3.3,1.8,2.6,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187790,FANCM,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 66.3265% (minimum 75%, Missing)",0.0642857,0.0831325,-0.0867347,0,80,unavailable,3.3,1.8,2.6,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187790,FANCM,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 66.3265% (minimum 75%, Missing)",0.0642857,0.0831325,-0.0867347,0,80,unavailable,3.3,1.8,2.6,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187790,FANCM,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 66.3265% (minimum 75%, Missing)",0.0642857,0.0831325,-0.0867347,0,80,unavailable,3.3,1.8,2.6,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187790,FANCM,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 66.3265% (minimum 75%, Baseline (adaptation disabled))",0.0642857,0.0831325,-0.0867347,0,80,unavailable,3.3,1.8,2.6,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187790,FANCM,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 97.5694% (minimum 99%, Missing); retina: 97.5694% (minimum 99%, Missing); skeletal muscle: 98.9437% (minimum 99%, Missing)",0.0394366,0.0125175,-0.0143056,0,80,unavailable,0.7,0.5,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187791,SPATA31F3,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.339437,0.282517,0.225694,0,80,unavailable,0.7,0.5,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187791,SPATA31F3,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.339437,0.282517,0.225694,0,80,unavailable,0.7,0.5,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187791,SPATA31F3,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.339437,0.282517,0.225694,0,80,unavailable,0.7,0.5,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187791,SPATA31F3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.339437,0.282517,0.225694,0,80,unavailable,0.7,0.5,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000187791,SPATA31F3,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.4545% (minimum 95%, Missing); adrenal gland: 72.0930% (minimum 99%, Missing); amygdala: 79.4872% (minimum 99%, Missing); basal ganglia: 77.5000% (minimum 99%, Missing); bone marrow: 65.9574% (minimum 99%, Missing); cerebellum: 68.8889% (minimum 99%, Missing); cerebral cortex: 72.0930% (minimum 99%, Missing); choroid plexus: 79.4872% (minimum 99%, Missing); colon: 68.8889% (minimum 97%, Missing); duodenum: 79.4872% (minimum 99%, Missing); esophagus: 79.4872% (minimum 97%, Missing); heart muscle: 67.3913% (minimum 99%, Missing); hippocampal formation: 75.6098% (minimum 99%, Missing); hypothalamus: 77.5000% (minimum 99%, Missing); kidney: 75.6098% (minimum 99%, Missing); liver: 81.5789% (minimum 99%, Missing); lung: 72.0930% (minimum 99%, Missing); lymph node: 68.8889% (minimum 97%, Missing); midbrain: 77.5000% (minimum 99%, Missing); pancreas: 64.5833% (minimum 99%, Missing); parathyroid gland: 59.6154% (minimum 97%, Missing); pituitary gland: 65.9574% (minimum 99%, Missing); rectum: 72.0930% (minimum 97%, Missing); retina: 51.6667% (minimum 99%, Missing); salivary gland: 60.7843% (minimum 97%, Missing); skeletal muscle: 55.3571% (minimum 99%, Missing); skin: 73.8095% (minimum 95%, Missing); small intestine: 72.0930% (minimum 99%, Missing); smooth muscle: 65.9574% (minimum 99%, Missing); spinal cord: 73.8095% (minimum 99%, Missing); spleen: 70.4545% (minimum 95%, Missing); stomach: 70.4545% (minimum 97%, Missing); thymus: 72.0930% (minimum 95%, Missing); thyroid gland: 63.2653% (minimum 95%, Missing); tongue: 59.6154% (minimum 97%, Missing); urinary bladder: 70.4545% (minimum 97%, Missing)",-0.317347,-0.373846,-0.473333,0,80,unavailable,2.9,2.1,1.8,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187792,ZNF70,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.0930% (minimum 75%, Missing); bone marrow: 65.9574% (minimum 75%, Missing); cerebellum: 68.8889% (minimum 75%, Missing); cerebral cortex: 72.0930% (minimum 75%, Missing); colon: 68.8889% (minimum 70%, Missing); heart muscle: 67.3913% (minimum 75%, Missing); lung: 72.0930% (minimum 75%, Missing); lymph node: 68.8889% (minimum 70%, Missing); pancreas: 64.5833% (minimum 75%, Missing); parathyroid gland: 59.6154% (minimum 70%, Missing); pituitary gland: 65.9574% (minimum 75%, Missing); retina: 51.6667% (minimum 75%, Missing); salivary gland: 60.7843% (minimum 70%, Missing); skeletal muscle: 55.3571% (minimum 75%, Missing); small intestine: 72.0930% (minimum 75%, Missing); smooth muscle: 65.9574% (minimum 75%, Missing); spinal cord: 73.8095% (minimum 75%, Missing); thyroid gland: 63.2653% (minimum 65%, Missing); tongue: 59.6154% (minimum 70%, Missing)",-0.0173469,-0.103846,-0.233333,0,80,unavailable,2.9,2.1,1.8,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187792,ZNF70,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.0930% (minimum 75%, Missing); bone marrow: 65.9574% (minimum 75%, Missing); cerebellum: 68.8889% (minimum 75%, Missing); cerebral cortex: 72.0930% (minimum 75%, Missing); colon: 68.8889% (minimum 70%, Missing); heart muscle: 67.3913% (minimum 75%, Missing); lung: 72.0930% (minimum 75%, Missing); lymph node: 68.8889% (minimum 70%, Missing); pancreas: 64.5833% (minimum 75%, Missing); parathyroid gland: 59.6154% (minimum 70%, Missing); pituitary gland: 65.9574% (minimum 75%, Missing); retina: 51.6667% (minimum 75%, Missing); salivary gland: 60.7843% (minimum 70%, Missing); skeletal muscle: 55.3571% (minimum 75%, Missing); small intestine: 72.0930% (minimum 75%, Missing); smooth muscle: 65.9574% (minimum 75%, Missing); spinal cord: 73.8095% (minimum 75%, Missing); thyroid gland: 63.2653% (minimum 65%, Missing); tongue: 59.6154% (minimum 70%, Missing)",-0.0173469,-0.103846,-0.233333,0,80,unavailable,2.9,2.1,1.8,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187792,ZNF70,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.0930% (minimum 75%, Missing); bone marrow: 65.9574% (minimum 75%, Missing); cerebellum: 68.8889% (minimum 75%, Missing); cerebral cortex: 72.0930% (minimum 75%, Missing); colon: 68.8889% (minimum 70%, Missing); heart muscle: 67.3913% (minimum 75%, Missing); lung: 72.0930% (minimum 75%, Missing); lymph node: 68.8889% (minimum 70%, Missing); pancreas: 64.5833% (minimum 75%, Missing); parathyroid gland: 59.6154% (minimum 70%, Missing); pituitary gland: 65.9574% (minimum 75%, Missing); retina: 51.6667% (minimum 75%, Missing); salivary gland: 60.7843% (minimum 70%, Missing); skeletal muscle: 55.3571% (minimum 75%, Missing); small intestine: 72.0930% (minimum 75%, Missing); smooth muscle: 65.9574% (minimum 75%, Missing); spinal cord: 73.8095% (minimum 75%, Missing); thyroid gland: 63.2653% (minimum 65%, Missing); tongue: 59.6154% (minimum 70%, Missing)",-0.0173469,-0.103846,-0.233333,0,80,unavailable,2.9,2.1,1.8,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187792,ZNF70,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.0930% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 65.9574% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.8889% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.0930% (minimum 75%, Baseline (adaptation disabled)); colon: 68.8889% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 67.3913% (minimum 75%, Baseline (adaptation disabled)); lung: 72.0930% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.8889% (minimum 70%, Baseline (adaptation disabled)); pancreas: 64.5833% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.6154% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 65.9574% (minimum 75%, Baseline (adaptation disabled)); retina: 51.6667% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.7843% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.3571% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.0930% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 65.9574% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.8095% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 63.2653% (minimum 65%, Baseline (adaptation disabled)); tongue: 59.6154% (minimum 70%, Baseline (adaptation disabled))",-0.0173469,-0.103846,-0.233333,0,80,unavailable,2.9,2.1,1.8,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187792,ZNF70,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187806,TMEM202,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187806,TMEM202,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187806,TMEM202,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187806,TMEM202,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187806,TMEM202,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.8148% (minimum 95%, Missing); adrenal gland: 72.9167% (minimum 99%, Missing); amygdala: 53.0303% (minimum 99%, Missing); basal ganglia: 52.2388% (minimum 99%, Missing); bone marrow: 64.8148% (minimum 99%, Missing); cerebellum: 60.3448% (minimum 99%, Missing); cerebral cortex: 60.3448% (minimum 99%, Missing); choroid plexus: 64.8148% (minimum 99%, Missing); colon: 57.3770% (minimum 97%, Missing); duodenum: 66.0377% (minimum 99%, Missing); esophagus: 64.8148% (minimum 97%, Missing); heart muscle: 67.3077% (minimum 99%, Missing); hippocampal formation: 54.6875% (minimum 99%, Missing); hypothalamus: 58.3333% (minimum 99%, Missing); kidney: 62.5000% (minimum 99%, Missing); liver: 64.8148% (minimum 99%, Missing); lung: 60.3448% (minimum 99%, Missing); lymph node: 55.5556% (minimum 97%, Missing); midbrain: 53.8462% (minimum 99%, Missing); pancreas: 59.3220% (minimum 99%, Missing); parathyroid gland: 59.3220% (minimum 97%, Missing); pituitary gland: 72.9167% (minimum 99%, Missing); rectum: 64.8148% (minimum 97%, Missing); retina: 63.6364% (minimum 99%, Missing); salivary gland: 67.3077% (minimum 97%, Missing); skeletal muscle: 87.5000% (minimum 99%, Missing); skin: 56.4516% (minimum 95%, Missing); small intestine: 60.3448% (minimum 99%, Missing); smooth muscle: 58.3333% (minimum 99%, Missing); spinal cord: 47.2973% (minimum 99%, Missing); spleen: 53.0303% (minimum 95%, Missing); stomach: 63.6364% (minimum 97%, Missing); thymus: 54.6875% (minimum 95%, Missing); thyroid gland: 63.6364% (minimum 95%, Missing); tongue: 81.3953% (minimum 97%, Missing); urinary bladder: 57.3770% (minimum 97%, Missing)",-0.419697,-0.414444,-0.517027,0,80,unavailable,3.9,2.8,3.1,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187815,ZFP69,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.8148% (minimum 65%, Missing); adrenal gland: 72.9167% (minimum 75%, Missing); amygdala: 53.0303% (minimum 75%, Missing); basal ganglia: 52.2388% (minimum 75%, Missing); bone marrow: 64.8148% (minimum 75%, Missing); cerebellum: 60.3448% (minimum 75%, Missing); cerebral cortex: 60.3448% (minimum 75%, Missing); choroid plexus: 64.8148% (minimum 75%, Missing); colon: 57.3770% (minimum 70%, Missing); duodenum: 66.0377% (minimum 75%, Missing); esophagus: 64.8148% (minimum 70%, Missing); heart muscle: 67.3077% (minimum 75%, Missing); hippocampal formation: 54.6875% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 64.8148% (minimum 75%, Missing); lung: 60.3448% (minimum 75%, Missing); lymph node: 55.5556% (minimum 70%, Missing); midbrain: 53.8462% (minimum 75%, Missing); pancreas: 59.3220% (minimum 75%, Missing); parathyroid gland: 59.3220% (minimum 70%, Missing); pituitary gland: 72.9167% (minimum 75%, Missing); rectum: 64.8148% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); salivary gland: 67.3077% (minimum 70%, Missing); skin: 56.4516% (minimum 65%, Missing); small intestine: 60.3448% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 75%, Missing); spinal cord: 47.2973% (minimum 75%, Missing); spleen: 53.0303% (minimum 65%, Missing); stomach: 63.6364% (minimum 70%, Missing); thymus: 54.6875% (minimum 65%, Missing); thyroid gland: 63.6364% (minimum 65%, Missing); urinary bladder: 57.3770% (minimum 70%, Missing)",-0.119697,-0.144444,-0.277027,0,80,unavailable,3.9,2.8,3.1,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187815,ZFP69,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.8148% (minimum 65%, Missing); adrenal gland: 72.9167% (minimum 75%, Missing); amygdala: 53.0303% (minimum 75%, Missing); basal ganglia: 52.2388% (minimum 75%, Missing); bone marrow: 64.8148% (minimum 75%, Missing); cerebellum: 60.3448% (minimum 75%, Missing); cerebral cortex: 60.3448% (minimum 75%, Missing); choroid plexus: 64.8148% (minimum 75%, Missing); colon: 57.3770% (minimum 70%, Missing); duodenum: 66.0377% (minimum 75%, Missing); esophagus: 64.8148% (minimum 70%, Missing); heart muscle: 67.3077% (minimum 75%, Missing); hippocampal formation: 54.6875% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 64.8148% (minimum 75%, Missing); lung: 60.3448% (minimum 75%, Missing); lymph node: 55.5556% (minimum 70%, Missing); midbrain: 53.8462% (minimum 75%, Missing); pancreas: 59.3220% (minimum 75%, Missing); parathyroid gland: 59.3220% (minimum 70%, Missing); pituitary gland: 72.9167% (minimum 75%, Missing); rectum: 64.8148% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); salivary gland: 67.3077% (minimum 70%, Missing); skin: 56.4516% (minimum 65%, Missing); small intestine: 60.3448% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 75%, Missing); spinal cord: 47.2973% (minimum 75%, Missing); spleen: 53.0303% (minimum 65%, Missing); stomach: 63.6364% (minimum 70%, Missing); thymus: 54.6875% (minimum 65%, Missing); thyroid gland: 63.6364% (minimum 65%, Missing); urinary bladder: 57.3770% (minimum 70%, Missing)",-0.119697,-0.144444,-0.277027,0,80,unavailable,3.9,2.8,3.1,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187815,ZFP69,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.8148% (minimum 65%, Missing); adrenal gland: 72.9167% (minimum 75%, Missing); amygdala: 53.0303% (minimum 75%, Missing); basal ganglia: 52.2388% (minimum 75%, Missing); bone marrow: 64.8148% (minimum 75%, Missing); cerebellum: 60.3448% (minimum 75%, Missing); cerebral cortex: 60.3448% (minimum 75%, Missing); choroid plexus: 64.8148% (minimum 75%, Missing); colon: 57.3770% (minimum 70%, Missing); duodenum: 66.0377% (minimum 75%, Missing); esophagus: 64.8148% (minimum 70%, Missing); heart muscle: 67.3077% (minimum 75%, Missing); hippocampal formation: 54.6875% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 64.8148% (minimum 75%, Missing); lung: 60.3448% (minimum 75%, Missing); lymph node: 55.5556% (minimum 70%, Missing); midbrain: 53.8462% (minimum 75%, Missing); pancreas: 59.3220% (minimum 75%, Missing); parathyroid gland: 59.3220% (minimum 70%, Missing); pituitary gland: 72.9167% (minimum 75%, Missing); rectum: 64.8148% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); salivary gland: 67.3077% (minimum 70%, Missing); skin: 56.4516% (minimum 65%, Missing); small intestine: 60.3448% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 75%, Missing); spinal cord: 47.2973% (minimum 75%, Missing); spleen: 53.0303% (minimum 65%, Missing); stomach: 63.6364% (minimum 70%, Missing); thymus: 54.6875% (minimum 65%, Missing); thyroid gland: 63.6364% (minimum 65%, Missing); urinary bladder: 57.3770% (minimum 70%, Missing)",-0.119697,-0.144444,-0.277027,0,80,unavailable,3.9,2.8,3.1,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187815,ZFP69,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.8148% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 72.9167% (minimum 75%, Baseline (adaptation disabled)); amygdala: 53.0303% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 52.2388% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 64.8148% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.3448% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.3448% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.8148% (minimum 75%, Baseline (adaptation disabled)); colon: 57.3770% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.0377% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.8148% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 67.3077% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.6875% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.3333% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.5000% (minimum 75%, Baseline (adaptation disabled)); liver: 64.8148% (minimum 75%, Baseline (adaptation disabled)); lung: 60.3448% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.5556% (minimum 70%, Baseline (adaptation disabled)); midbrain: 53.8462% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.3220% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 59.3220% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 72.9167% (minimum 75%, Baseline (adaptation disabled)); rectum: 64.8148% (minimum 70%, Baseline (adaptation disabled)); retina: 63.6364% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 67.3077% (minimum 70%, Baseline (adaptation disabled)); skin: 56.4516% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.3448% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 47.2973% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.0303% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.6364% (minimum 70%, Baseline (adaptation disabled)); thymus: 54.6875% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 63.6364% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 57.3770% (minimum 70%, Baseline (adaptation disabled))",-0.119697,-0.144444,-0.277027,0,80,unavailable,3.9,2.8,3.1,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187815,ZFP69,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187833,C2orf78,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187833,C2orf78,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187833,C2orf78,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187833,C2orf78,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187833,C2orf78,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.3737% (minimum 99%, Missing); amygdala: 87.0130% (minimum 99%, Missing); basal ganglia: 85.6230% (minimum 99%, Missing); bone marrow: 93.3798% (minimum 99%, Missing); cerebellum: 93.7063% (minimum 99%, Missing); cerebral cortex: 85.8974% (minimum 99%, Missing); choroid plexus: 81.2121% (minimum 99%, Missing); colon: 96.7509% (minimum 97%, Missing); duodenum: 95.3737% (minimum 99%, Missing); esophagus: 96.0573% (minimum 97%, Missing); heart muscle: 97.4545% (minimum 99%, Missing); hippocampal formation: 85.3503% (minimum 99%, Missing); hypothalamus: 81.7073% (minimum 99%, Missing); kidney: 90.2357% (minimum 99%, Missing); liver: 96.7509% (minimum 99%, Missing); lung: 92.7336% (minimum 99%, Missing); lymph node: 95.7143% (minimum 97%, Missing); midbrain: 91.4676% (minimum 99%, Missing); pancreas: 93.0556% (minimum 99%, Missing); parathyroid gland: 92.4138% (minimum 97%, Missing); pituitary gland: 84.5426% (minimum 99%, Missing); retina: 92.4138% (minimum 99%, Missing); salivary gland: 95.0355% (minimum 97%, Missing); skeletal muscle: 97.4545% (minimum 99%, Missing); small intestine: 96.0573% (minimum 99%, Missing); smooth muscle: 98.5294% (minimum 99%, Missing); spinal cord: 95.0355% (minimum 99%, Missing); spleen: 94.3662% (minimum 95%, Missing); stomach: 96.0573% (minimum 97%, Missing); thyroid gland: 88.4488% (minimum 95%, Missing); urinary bladder: 96.7509% (minimum 97%, Missing)",-0.0655116,-0.0458621,-0.177879,0,80,unavailable,6.2,2.2,3.5,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187860,CCDC157,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.234488,0.224138,0.0621212,0,80,unavailable,6.2,2.2,3.5,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187860,CCDC157,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.234488,0.224138,0.0621212,0,80,unavailable,6.2,2.2,3.5,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187860,CCDC157,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.234488,0.224138,0.0621212,0,80,unavailable,6.2,2.2,3.5,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187860,CCDC157,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.234488,0.224138,0.0621212,0,80,unavailable,6.2,2.2,3.5,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187860,CCDC157,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187918,OR51I2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187918,OR51I2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187918,OR51I2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187918,OR51I2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187918,OR51I2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187969,ZCCHC13,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187969,ZCCHC13,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187969,ZCCHC13,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187969,ZCCHC13,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187969,ZCCHC13,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Missing); adrenal gland: 78.5714% (minimum 99%, Missing); cerebellum: 78.5714% (minimum 99%, Missing); cerebral cortex: 84.6154% (minimum 99%, Missing); choroid plexus: 91.6667% (minimum 99%, Missing); colon: 84.6154% (minimum 97%, Missing); duodenum: 91.6667% (minimum 99%, Uncertain); esophagus: 91.6667% (minimum 97%, Missing); heart muscle: 84.6154% (minimum 99%, Missing); kidney: 84.6154% (minimum 99%, Missing); lung: 84.6154% (minimum 99%, Missing); lymph node: 84.6154% (minimum 97%, Uncertain); pancreas: 78.5714% (minimum 99%, Missing); parathyroid gland: 61.1111% (minimum 97%, Uncertain); pituitary gland: 78.5714% (minimum 99%, Missing); rectum: 78.5714% (minimum 97%, Missing); retina: 47.8261% (minimum 99%, Missing); salivary gland: 68.7500% (minimum 97%, Missing); skin: 91.6667% (minimum 95%, Missing); small intestine: 84.6154% (minimum 99%, Uncertain); smooth muscle: 78.5714% (minimum 99%, Missing); spinal cord: 91.6667% (minimum 99%, Missing); spleen: 78.5714% (minimum 95%, Uncertain); stomach: 91.6667% (minimum 97%, Missing); thymus: 84.6154% (minimum 95%, Missing); thyroid gland: 57.8947% (minimum 95%, Missing); tongue: 91.6667% (minimum 97%, Missing); urinary bladder: 84.6154% (minimum 97%, Missing)",-0.371053,-0.358889,-0.511739,0,2,partial,1.2,0.7,0.8,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187987,ZSCAN23,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"parathyroid gland: 61.1111% (minimum 70%, Uncertain); retina: 47.8261% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); thyroid gland: 57.8947% (minimum 65%, Missing)",-0.0710526,-0.0888889,-0.271739,0,2,partial,1.2,0.7,0.8,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187987,ZSCAN23,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"parathyroid gland: 61.1111% (minimum 70%, Uncertain); retina: 47.8261% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); thyroid gland: 57.8947% (minimum 65%, Missing)",-0.0710526,-0.0888889,-0.271739,0,2,partial,1.2,0.7,0.8,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187987,ZSCAN23,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"parathyroid gland: 61.1111% (minimum 70%, Uncertain); retina: 47.8261% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); thyroid gland: 57.8947% (minimum 65%, Missing)",-0.0710526,-0.0888889,-0.271739,0,2,partial,1.2,0.7,0.8,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187987,ZSCAN23,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"parathyroid gland: 61.1111% (minimum 70%, Baseline (adaptation disabled)); retina: 47.8261% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.7500% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 57.8947% (minimum 65%, Baseline (adaptation disabled))",-0.0710526,-0.0888889,-0.271739,0,2,partial,1.2,0.7,0.8,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187987,ZSCAN23,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 98.4615% (minimum 99%, Missing); pancreas: 98.4615% (minimum 99%, Missing); pituitary gland: 98.4615% (minimum 99%, Missing); stomach: 96.9697% (minimum 97%, Missing)",0.0346154,-0.00030303,-0.00538462,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188032,C19orf67,admission_only,True,False,False,False,10.1002/cam4.2223;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.334615,0.269697,0.234615,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188032,C19orf67,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.334615,0.269697,0.234615,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188032,C19orf67,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.334615,0.269697,0.234615,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188032,C19orf67,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.334615,0.269697,0.234615,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188032,C19orf67,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Missing); adrenal gland: 68.9655% (minimum 99%, Missing); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 80.0000% (minimum 99%, Missing); bone marrow: 55.5556% (minimum 99%, Missing); cerebellum: 74.0741% (minimum 99%, Missing); cerebral cortex: 51.2821% (minimum 99%, Missing); choroid plexus: 58.8235% (minimum 99%, Missing); colon: 64.5161% (minimum 97%, Missing); duodenum: 64.5161% (minimum 99%, Missing); esophagus: 71.4286% (minimum 97%, Missing); heart muscle: 71.4286% (minimum 99%, Missing); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 83.3333% (minimum 99%, Missing); kidney: 62.5000% (minimum 99%, Missing); liver: 54.0541% (minimum 99%, Missing); lung: 60.6061% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 86.9565% (minimum 99%, Missing); pancreas: 58.8235% (minimum 99%, Missing); parathyroid gland: 52.6316% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 62.5000% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 64.5161% (minimum 97%, Missing); skeletal muscle: 68.9655% (minimum 99%, Missing); skin: 54.0541% (minimum 95%, Missing); small intestine: 71.4286% (minimum 99%, Missing); smooth muscle: 68.9655% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 46.5116% (minimum 95%, Missing); stomach: 64.5161% (minimum 97%, Missing); thymus: 48.7805% (minimum 95%, Missing); thyroid gland: 47.6190% (minimum 95%, Missing); tongue: 66.6667% (minimum 97%, Missing); urinary bladder: 68.9655% (minimum 97%, Missing)",-0.484884,-0.47,-0.49,0,80,unavailable,2,2,2.3,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188033,ZNF490,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.9655% (minimum 75%, Missing); bone marrow: 55.5556% (minimum 75%, Missing); cerebellum: 74.0741% (minimum 75%, Missing); cerebral cortex: 51.2821% (minimum 75%, Missing); choroid plexus: 58.8235% (minimum 75%, Missing); colon: 64.5161% (minimum 70%, Missing); duodenum: 64.5161% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 54.0541% (minimum 75%, Missing); lung: 60.6061% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 58.8235% (minimum 75%, Missing); parathyroid gland: 52.6316% (minimum 70%, Missing); rectum: 62.5000% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 64.5161% (minimum 70%, Missing); skeletal muscle: 68.9655% (minimum 75%, Missing); skin: 54.0541% (minimum 65%, Missing); small intestine: 71.4286% (minimum 75%, Missing); smooth muscle: 68.9655% (minimum 75%, Missing); spleen: 46.5116% (minimum 65%, Missing); stomach: 64.5161% (minimum 70%, Missing); thymus: 48.7805% (minimum 65%, Missing); thyroid gland: 47.6190% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 68.9655% (minimum 70%, Missing)",-0.184884,-0.2,-0.25,0,80,unavailable,2,2,2.3,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188033,ZNF490,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.9655% (minimum 75%, Missing); bone marrow: 55.5556% (minimum 75%, Missing); cerebellum: 74.0741% (minimum 75%, Missing); cerebral cortex: 51.2821% (minimum 75%, Missing); choroid plexus: 58.8235% (minimum 75%, Missing); colon: 64.5161% (minimum 70%, Missing); duodenum: 64.5161% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 54.0541% (minimum 75%, Missing); lung: 60.6061% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 58.8235% (minimum 75%, Missing); parathyroid gland: 52.6316% (minimum 70%, Missing); rectum: 62.5000% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 64.5161% (minimum 70%, Missing); skeletal muscle: 68.9655% (minimum 75%, Missing); skin: 54.0541% (minimum 65%, Missing); small intestine: 71.4286% (minimum 75%, Missing); smooth muscle: 68.9655% (minimum 75%, Missing); spleen: 46.5116% (minimum 65%, Missing); stomach: 64.5161% (minimum 70%, Missing); thymus: 48.7805% (minimum 65%, Missing); thyroid gland: 47.6190% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 68.9655% (minimum 70%, Missing)",-0.184884,-0.2,-0.25,0,80,unavailable,2,2,2.3,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188033,ZNF490,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.9655% (minimum 75%, Missing); bone marrow: 55.5556% (minimum 75%, Missing); cerebellum: 74.0741% (minimum 75%, Missing); cerebral cortex: 51.2821% (minimum 75%, Missing); choroid plexus: 58.8235% (minimum 75%, Missing); colon: 64.5161% (minimum 70%, Missing); duodenum: 64.5161% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 54.0541% (minimum 75%, Missing); lung: 60.6061% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 58.8235% (minimum 75%, Missing); parathyroid gland: 52.6316% (minimum 70%, Missing); rectum: 62.5000% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 64.5161% (minimum 70%, Missing); skeletal muscle: 68.9655% (minimum 75%, Missing); skin: 54.0541% (minimum 65%, Missing); small intestine: 71.4286% (minimum 75%, Missing); smooth muscle: 68.9655% (minimum 75%, Missing); spleen: 46.5116% (minimum 65%, Missing); stomach: 64.5161% (minimum 70%, Missing); thymus: 48.7805% (minimum 65%, Missing); thyroid gland: 47.6190% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 68.9655% (minimum 70%, Missing)",-0.184884,-0.2,-0.25,0,80,unavailable,2,2,2.3,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188033,ZNF490,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.9655% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 55.5556% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.0741% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.2821% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.8235% (minimum 75%, Baseline (adaptation disabled)); colon: 64.5161% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.5161% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.5000% (minimum 75%, Baseline (adaptation disabled)); liver: 54.0541% (minimum 75%, Baseline (adaptation disabled)); lung: 60.6061% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 58.8235% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.6316% (minimum 70%, Baseline (adaptation disabled)); rectum: 62.5000% (minimum 70%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.5161% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 68.9655% (minimum 75%, Baseline (adaptation disabled)); skin: 54.0541% (minimum 65%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.9655% (minimum 75%, Baseline (adaptation disabled)); spleen: 46.5116% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.5161% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.7805% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 47.6190% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 68.9655% (minimum 70%, Baseline (adaptation disabled))",-0.184884,-0.2,-0.25,0,80,unavailable,2,2,2.3,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188033,ZNF490,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0451456,0.0227361,0.000338164,0,80,unavailable,0.4,0.3,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188050,RNF133,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345146,0.292736,0.240338,0,80,unavailable,0.4,0.3,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188050,RNF133,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345146,0.292736,0.240338,0,80,unavailable,0.4,0.3,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188050,RNF133,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345146,0.292736,0.240338,0,80,unavailable,0.4,0.3,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188050,RNF133,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345146,0.292736,0.240338,0,80,unavailable,0.4,0.3,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188050,RNF133,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.3540% (minimum 95%, Missing); adrenal gland: 60.0000% (minimum 99%, Missing); amygdala: 67.1053% (minimum 99%, Missing); basal ganglia: 67.1053% (minimum 99%, Missing); bone marrow: 77.2727% (minimum 99%, Missing); cerebellum: 60.0000% (minimum 99%, Missing); cerebral cortex: 61.0778% (minimum 99%, Missing); choroid plexus: 87.1795% (minimum 99%, Missing); colon: 66.2338% (minimum 97%, Missing); duodenum: 86.4407% (minimum 99%, Missing); esophagus: 64.9682% (minimum 97%, Missing); heart muscle: 64.9682% (minimum 99%, Missing); hippocampal formation: 68.0000% (minimum 99%, Missing); hypothalamus: 60.0000% (minimum 99%, Missing); kidney: 45.9459% (minimum 99%, Missing); liver: 59.3023% (minimum 99%, Missing); lung: 65.8065% (minimum 99%, Missing); lymph node: 87.9310% (minimum 97%, Missing); midbrain: 63.7500% (minimum 99%, Missing); pancreas: 70.3448% (minimum 99%, Missing); parathyroid gland: 77.2727% (minimum 97%, Missing); pituitary gland: 68.4564% (minimum 99%, Missing); rectum: 82.9268% (minimum 97%, Missing); retina: 83.6066% (minimum 99%, Missing); salivary gland: 58.9595% (minimum 97%, Missing); skeletal muscle: 54.5455% (minimum 99%, Missing); skin: 55.4348% (minimum 95%, Missing); small intestine: 59.6491% (minimum 99%, Missing); smooth muscle: 90.2655% (minimum 99%, Missing); spinal cord: 56.9832% (minimum 99%, Missing); spleen: 67.5497% (minimum 95%, Missing); stomach: 62.1951% (minimum 97%, Missing); thymus: 79.6875% (minimum 95%, Missing); thyroid gland: 68.9189% (minimum 95%, Missing); tongue: 64.1509% (minimum 97%, Missing); urinary bladder: 62.5767% (minimum 97%, Missing)",-0.395652,-0.380405,-0.530541,0,80,unavailable,12,7.1,8.2,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); salivary gland: 7.1 nTPM (protected, limit 2); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); heart muscle: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188092,GPR89B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.3540% (minimum 65%, Missing); adrenal gland: 60.0000% (minimum 75%, Missing); amygdala: 67.1053% (minimum 75%, Missing); basal ganglia: 67.1053% (minimum 75%, Missing); cerebellum: 60.0000% (minimum 75%, Missing); cerebral cortex: 61.0778% (minimum 75%, Missing); colon: 66.2338% (minimum 70%, Missing); esophagus: 64.9682% (minimum 70%, Missing); heart muscle: 64.9682% (minimum 75%, Missing); hippocampal formation: 68.0000% (minimum 75%, Missing); hypothalamus: 60.0000% (minimum 75%, Missing); kidney: 45.9459% (minimum 75%, Missing); liver: 59.3023% (minimum 75%, Missing); lung: 65.8065% (minimum 75%, Missing); midbrain: 63.7500% (minimum 75%, Missing); pancreas: 70.3448% (minimum 75%, Missing); pituitary gland: 68.4564% (minimum 75%, Missing); salivary gland: 58.9595% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 55.4348% (minimum 65%, Missing); small intestine: 59.6491% (minimum 75%, Missing); spinal cord: 56.9832% (minimum 75%, Missing); stomach: 62.1951% (minimum 70%, Missing); tongue: 64.1509% (minimum 70%, Missing); urinary bladder: 62.5767% (minimum 70%, Missing)",-0.0956522,-0.110405,-0.290541,0,80,unavailable,12,7.1,8.2,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); salivary gland: 7.1 nTPM (protected, limit 2); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); heart muscle: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188092,GPR89B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.3540% (minimum 65%, Missing); adrenal gland: 60.0000% (minimum 75%, Missing); amygdala: 67.1053% (minimum 75%, Missing); basal ganglia: 67.1053% (minimum 75%, Missing); cerebellum: 60.0000% (minimum 75%, Missing); cerebral cortex: 61.0778% (minimum 75%, Missing); colon: 66.2338% (minimum 70%, Missing); esophagus: 64.9682% (minimum 70%, Missing); heart muscle: 64.9682% (minimum 75%, Missing); hippocampal formation: 68.0000% (minimum 75%, Missing); hypothalamus: 60.0000% (minimum 75%, Missing); kidney: 45.9459% (minimum 75%, Missing); liver: 59.3023% (minimum 75%, Missing); lung: 65.8065% (minimum 75%, Missing); midbrain: 63.7500% (minimum 75%, Missing); pancreas: 70.3448% (minimum 75%, Missing); pituitary gland: 68.4564% (minimum 75%, Missing); salivary gland: 58.9595% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 55.4348% (minimum 65%, Missing); small intestine: 59.6491% (minimum 75%, Missing); spinal cord: 56.9832% (minimum 75%, Missing); stomach: 62.1951% (minimum 70%, Missing); tongue: 64.1509% (minimum 70%, Missing); urinary bladder: 62.5767% (minimum 70%, Missing)",-0.0956522,-0.110405,-0.290541,0,80,unavailable,12,7.1,8.2,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); salivary gland: 7.1 nTPM (protected, limit 3); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); esophagus: 5.5 nTPM (protected, limit 3); heart muscle: 5.5 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188092,GPR89B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.3540% (minimum 65%, Missing); adrenal gland: 60.0000% (minimum 75%, Missing); amygdala: 67.1053% (minimum 75%, Missing); basal ganglia: 67.1053% (minimum 75%, Missing); cerebellum: 60.0000% (minimum 75%, Missing); cerebral cortex: 61.0778% (minimum 75%, Missing); colon: 66.2338% (minimum 70%, Missing); esophagus: 64.9682% (minimum 70%, Missing); heart muscle: 64.9682% (minimum 75%, Missing); hippocampal formation: 68.0000% (minimum 75%, Missing); hypothalamus: 60.0000% (minimum 75%, Missing); kidney: 45.9459% (minimum 75%, Missing); liver: 59.3023% (minimum 75%, Missing); lung: 65.8065% (minimum 75%, Missing); midbrain: 63.7500% (minimum 75%, Missing); pancreas: 70.3448% (minimum 75%, Missing); pituitary gland: 68.4564% (minimum 75%, Missing); salivary gland: 58.9595% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 55.4348% (minimum 65%, Missing); small intestine: 59.6491% (minimum 75%, Missing); spinal cord: 56.9832% (minimum 75%, Missing); stomach: 62.1951% (minimum 70%, Missing); tongue: 64.1509% (minimum 70%, Missing); urinary bladder: 62.5767% (minimum 70%, Missing)",-0.0956522,-0.110405,-0.290541,0,80,unavailable,12,7.1,8.2,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); salivary gland: 7.1 nTPM (protected, limit 3); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); esophagus: 5.5 nTPM (protected, limit 3); heart muscle: 5.5 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188092,GPR89B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.3540% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 67.1053% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 67.1053% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.0778% (minimum 75%, Baseline (adaptation disabled)); colon: 66.2338% (minimum 70%, Baseline (adaptation disabled)); esophagus: 64.9682% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.9682% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 45.9459% (minimum 75%, Baseline (adaptation disabled)); liver: 59.3023% (minimum 75%, Baseline (adaptation disabled)); lung: 65.8065% (minimum 75%, Baseline (adaptation disabled)); midbrain: 63.7500% (minimum 75%, Baseline (adaptation disabled)); pancreas: 70.3448% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 68.4564% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.9595% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 54.5455% (minimum 75%, Baseline (adaptation disabled)); skin: 55.4348% (minimum 65%, Baseline (adaptation disabled)); small intestine: 59.6491% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.9832% (minimum 75%, Baseline (adaptation disabled)); stomach: 62.1951% (minimum 70%, Baseline (adaptation disabled)); tongue: 64.1509% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.5767% (minimum 70%, Baseline (adaptation disabled))",-0.0956522,-0.110405,-0.290541,0,80,unavailable,12,7.1,8.2,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); salivary gland: 7.1 nTPM (protected, limit 3); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); esophagus: 5.5 nTPM (protected, limit 3); heart muscle: 5.5 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188092,GPR89B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.00909091,0.01,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188120,DAZ1,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188120,DAZ1,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188120,DAZ1,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188120,DAZ1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.209091,0.25,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188120,DAZ1,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 7.4074% (minimum 95%, Missing)",-0.875926,0.03,0.01,0,80,unavailable,0,0,2.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188155,KRTAP10-6,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 7.4074% (minimum 65%, Missing)",-0.575926,0.3,0.25,0,80,unavailable,0,0,2.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188155,KRTAP10-6,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 7.4074% (minimum 65%, Missing)",-0.575926,0.3,0.25,0,80,unavailable,0,0,2.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188155,KRTAP10-6,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 7.4074% (minimum 65%, Missing)",-0.575926,0.3,0.25,0,80,unavailable,0,0,2.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188155,KRTAP10-6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 7.4074% (minimum 65%, Baseline (adaptation disabled))",-0.575926,0.3,0.25,0,80,unavailable,0,0,2.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188155,KRTAP10-6,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 88.8889% (minimum 99%, Missing); pituitary gland: 38.0952% (minimum 99%, Missing); retina: 61.5385% (minimum 99%, Missing)",0.05,0.03,-0.609048,0,80,unavailable,1.3,0,0,"pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188162,OTOG,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pituitary gland: 38.0952% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing)",0.35,0.3,-0.369048,0,80,unavailable,1.3,0,0,"pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188162,OTOG,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pituitary gland: 38.0952% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing)",0.35,0.3,-0.369048,0,80,unavailable,1.3,0,0,"pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188162,OTOG,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pituitary gland: 38.0952% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing)",0.35,0.3,-0.369048,0,80,unavailable,1.3,0,0,"pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188162,OTOG,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pituitary gland: 38.0952% (minimum 75%, Baseline (adaptation disabled)); retina: 61.5385% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.369048,0,80,unavailable,1.3,0,0,"pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188162,OTOG,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 98.5000% (minimum 99%, Missing)",0.05,0.03,-0.005,0,3,partial,1.8,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188163,CIMIP2A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235,0,3,partial,1.8,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188163,CIMIP2A,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235,0,3,partial,1.8,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188163,CIMIP2A,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235,0,3,partial,1.8,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188163,CIMIP2A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33995,0.293277,0.220443,0,3,partial,1.8,0.4,0.6,"liver: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188163,CIMIP2A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 70.5882% (minimum 99%, Missing); amygdala: 85.7143% (minimum 99%, Missing); basal ganglia: 85.7143% (minimum 99%, Missing); bone marrow: 18.1818% (minimum 99%, Missing); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 54.5455% (minimum 99%, Missing); choroid plexus: 70.5882% (minimum 99%, Missing); colon: 57.1429% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); liver: 70.5882% (minimum 99%, Missing); lung: 54.5455% (minimum 99%, Missing); lymph node: 52.1739% (minimum 97%, Missing); midbrain: 92.3077% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 40.0000% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 50.0000% (minimum 97%, Missing); retina: 30.7692% (minimum 99%, Missing); salivary gland: 63.1579% (minimum 97%, Missing); skeletal muscle: 85.7143% (minimum 99%, Missing); skin: 52.1739% (minimum 95%, Missing); small intestine: 52.1739% (minimum 99%, Missing); smooth muscle: 60.0000% (minimum 98%, Approved); spinal cord: 92.3077% (minimum 99%, Missing); spleen: 44.4444% (minimum 95%, Missing); stomach: 48.0000% (minimum 97%, Missing); thymus: 75.0000% (minimum 95%, Missing); thyroid gland: 54.5455% (minimum 95%, Missing); tongue: 80.0000% (minimum 97%, Missing); urinary bladder: 63.1579% (minimum 97%, Missing)",-0.505556,-0.57,-0.808182,0,1,partial,5.4,1.8,1.5,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188167,TMPPE,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.5882% (minimum 75%, Missing); bone marrow: 18.1818% (minimum 75%, Missing); cerebral cortex: 54.5455% (minimum 75%, Missing); choroid plexus: 70.5882% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 70.5882% (minimum 75%, Missing); lung: 54.5455% (minimum 75%, Missing); lymph node: 52.1739% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 40.0000% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 30.7692% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skin: 52.1739% (minimum 65%, Missing); small intestine: 52.1739% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 70%, Approved); spleen: 44.4444% (minimum 65%, Missing); stomach: 48.0000% (minimum 70%, Missing); thyroid gland: 54.5455% (minimum 65%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.205556,-0.3,-0.568182,0,1,partial,5.4,1.8,1.5,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188167,TMPPE,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.5882% (minimum 75%, Missing); bone marrow: 18.1818% (minimum 75%, Missing); cerebral cortex: 54.5455% (minimum 75%, Missing); choroid plexus: 70.5882% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 70.5882% (minimum 75%, Missing); lung: 54.5455% (minimum 75%, Missing); lymph node: 52.1739% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 40.0000% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 30.7692% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skin: 52.1739% (minimum 65%, Missing); small intestine: 52.1739% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 70%, Approved); spleen: 44.4444% (minimum 65%, Missing); stomach: 48.0000% (minimum 70%, Missing); thyroid gland: 54.5455% (minimum 65%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.205556,-0.3,-0.568182,0,1,partial,5.4,1.8,1.5,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188167,TMPPE,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.5882% (minimum 75%, Missing); bone marrow: 18.1818% (minimum 75%, Missing); cerebral cortex: 54.5455% (minimum 75%, Missing); choroid plexus: 70.5882% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 70.5882% (minimum 75%, Missing); lung: 54.5455% (minimum 75%, Missing); lymph node: 52.1739% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 40.0000% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 30.7692% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skin: 52.1739% (minimum 65%, Missing); small intestine: 52.1739% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 70%, Approved); spleen: 44.4444% (minimum 65%, Missing); stomach: 48.0000% (minimum 70%, Missing); thyroid gland: 54.5455% (minimum 65%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.205556,-0.3,-0.568182,0,1,partial,5.4,1.8,1.5,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188167,TMPPE,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.5882% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 18.1818% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 54.5455% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.5882% (minimum 75%, Baseline (adaptation disabled)); colon: 57.1429% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 75%, Baseline (adaptation disabled)); liver: 70.5882% (minimum 75%, Baseline (adaptation disabled)); lung: 54.5455% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.1739% (minimum 70%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 40.0000% (minimum 70%, Baseline (adaptation disabled)); rectum: 50.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 30.7692% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.1579% (minimum 70%, Baseline (adaptation disabled)); skin: 52.1739% (minimum 65%, Baseline (adaptation disabled)); small intestine: 52.1739% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 44.4444% (minimum 65%, Baseline (adaptation disabled)); stomach: 48.0000% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 54.5455% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 63.1579% (minimum 70%, Baseline (adaptation disabled))",-0.205556,-0.3,-0.568182,0,1,partial,5.4,1.8,1.5,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188167,TMPPE,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.9104% (minimum 95%, Uncertain); adrenal gland: 71.0884% (minimum 99%, Missing); amygdala: 85.3061% (minimum 99%, Missing); basal ganglia: 85.3061% (minimum 99%, Missing); bone marrow: 84.9593% (minimum 99%, Missing); cerebellum: 89.3162% (minimum 99%, Missing); cerebral cortex: 73.5915% (minimum 99%, Missing); choroid plexus: 83.6000% (minimum 99%, Missing); colon: 86.0082% (minimum 97%, Missing); duodenum: 93.3036% (minimum 99%, Missing); esophagus: 77.6952% (minimum 97%, Missing); heart muscle: 68.7500% (minimum 99%, Missing); hippocampal formation: 85.6557% (minimum 99%, Missing); hypothalamus: 84.9593% (minimum 99%, Missing); kidney: 66.7732% (minimum 99%, Uncertain); liver: 79.7710% (minimum 99%, Uncertain); lung: 81.0078% (minimum 99%, Missing); lymph node: 63.9144% (minimum 97%, Uncertain); midbrain: 84.9593% (minimum 99%, Missing); pancreas: 75.4513% (minimum 99%, Missing); parathyroid gland: 51.9900% (minimum 97%, Missing); pituitary gland: 86.0082% (minimum 99%, Missing); rectum: 87.4477% (minimum 97%, Missing); retina: 74.6429% (minimum 99%, Missing); salivary gland: 75.7246% (minimum 97%, Missing); skeletal muscle: 82.9365% (minimum 99%, Missing); skin: 69.8997% (minimum 95%, Missing); small intestine: 90.0862% (minimum 99%, Missing); smooth muscle: 70.3704% (minimum 99%, Missing); spinal cord: 85.3061% (minimum 99%, Missing); spleen: 75.7246% (minimum 95%, Missing); stomach: 72.8223% (minimum 97%, Missing); thymus: 71.8213% (minimum 95%, Missing); thyroid gland: 49.0610% (minimum 95%, Missing); tongue: 78.8679% (minimum 97%, Missing); urinary bladder: 60.2305% (minimum 97%, Missing)",-0.45939,-0.4501,-0.322268,0,3,partial,10.4,19.3,21.7,"thyroid gland: 21.7 nTPM (manageable, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 2); urinary bladder: 13.8 nTPM (protected, limit 2); lymph node: 11.8 nTPM (protected, limit 2); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); smooth muscle: 8.8 nTPM (vital, limit 1); adrenal gland: 8.5 nTPM (vital, limit 1); thymus: 8.2 nTPM (manageable, limit 5); stomach: 7.8 nTPM (protected, limit 2); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); spleen: 6.7 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 2); tongue: 5.6 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188171,ZNF626,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.0884% (minimum 75%, Missing); cerebral cortex: 73.5915% (minimum 75%, Missing); heart muscle: 68.7500% (minimum 75%, Missing); kidney: 66.7732% (minimum 75%, Uncertain); lymph node: 63.9144% (minimum 70%, Uncertain); parathyroid gland: 51.9900% (minimum 70%, Missing); retina: 74.6429% (minimum 75%, Missing); smooth muscle: 70.3704% (minimum 75%, Missing); thyroid gland: 49.0610% (minimum 65%, Missing); urinary bladder: 60.2305% (minimum 70%, Missing)",-0.15939,-0.1801,-0.0822684,0,3,partial,10.4,19.3,21.7,"thyroid gland: 21.7 nTPM (manageable, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 2); urinary bladder: 13.8 nTPM (protected, limit 2); lymph node: 11.8 nTPM (protected, limit 2); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); smooth muscle: 8.8 nTPM (vital, limit 1); adrenal gland: 8.5 nTPM (vital, limit 1); thymus: 8.2 nTPM (manageable, limit 5); stomach: 7.8 nTPM (protected, limit 2); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); spleen: 6.7 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 2); tongue: 5.6 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188171,ZNF626,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.0884% (minimum 75%, Missing); cerebral cortex: 73.5915% (minimum 75%, Missing); heart muscle: 68.7500% (minimum 75%, Missing); kidney: 66.7732% (minimum 75%, Uncertain); lymph node: 63.9144% (minimum 70%, Uncertain); parathyroid gland: 51.9900% (minimum 70%, Missing); retina: 74.6429% (minimum 75%, Missing); smooth muscle: 70.3704% (minimum 75%, Missing); thyroid gland: 49.0610% (minimum 65%, Missing); urinary bladder: 60.2305% (minimum 70%, Missing)",-0.15939,-0.1801,-0.0822684,0,3,partial,10.4,19.3,21.7,"thyroid gland: 21.7 nTPM (manageable, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 3); urinary bladder: 13.8 nTPM (protected, limit 3); lymph node: 11.8 nTPM (protected, limit 3); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); smooth muscle: 8.8 nTPM (vital, limit 1); adrenal gland: 8.5 nTPM (vital, limit 1); thymus: 8.2 nTPM (manageable, limit 5); stomach: 7.8 nTPM (protected, limit 3); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); spleen: 6.7 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 3); tongue: 5.6 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188171,ZNF626,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.0884% (minimum 75%, Missing); cerebral cortex: 73.5915% (minimum 75%, Missing); heart muscle: 68.7500% (minimum 75%, Missing); kidney: 66.7732% (minimum 75%, Uncertain); lymph node: 63.9144% (minimum 70%, Uncertain); parathyroid gland: 51.9900% (minimum 70%, Missing); retina: 74.6429% (minimum 75%, Missing); smooth muscle: 70.3704% (minimum 75%, Missing); thyroid gland: 49.0610% (minimum 65%, Missing); urinary bladder: 60.2305% (minimum 70%, Missing)",-0.15939,-0.1801,-0.0822684,0,3,partial,10.4,19.3,21.7,"thyroid gland: 21.7 nTPM (manageable, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 3); urinary bladder: 13.8 nTPM (protected, limit 3); lymph node: 11.8 nTPM (protected, limit 3); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); smooth muscle: 8.8 nTPM (vital, limit 1); adrenal gland: 8.5 nTPM (vital, limit 1); thymus: 8.2 nTPM (manageable, limit 5); stomach: 7.8 nTPM (protected, limit 3); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); spleen: 6.7 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 3); tongue: 5.6 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188171,ZNF626,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.0884% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.5915% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 68.7500% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.7732% (minimum 75%, Baseline (adaptation disabled)); lymph node: 63.9144% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 51.9900% (minimum 70%, Baseline (adaptation disabled)); retina: 74.6429% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.3704% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 49.0610% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 60.2305% (minimum 70%, Baseline (adaptation disabled))",-0.15939,-0.1801,-0.0822684,0,3,partial,10.4,19.3,21.7,"thyroid gland: 21.7 nTPM (manageable, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 3); urinary bladder: 13.8 nTPM (protected, limit 3); lymph node: 11.8 nTPM (protected, limit 3); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); smooth muscle: 8.8 nTPM (vital, limit 1); adrenal gland: 8.5 nTPM (vital, limit 1); thymus: 8.2 nTPM (manageable, limit 5); stomach: 7.8 nTPM (protected, limit 3); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); spleen: 6.7 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 3); tongue: 5.6 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188171,ZNF626,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.6279% (minimum 95%, Missing); adrenal gland: 74.6479% (minimum 99%, Missing); amygdala: 80.3030% (minimum 99%, Missing); basal ganglia: 81.5385% (minimum 99%, Missing); bone marrow: 31.5476% (minimum 99%, Missing); cerebellum: 64.6341% (minimum 99%, Missing); cerebral cortex: 62.3529% (minimum 99%, Missing); choroid plexus: 74.6479% (minimum 99%, Missing); colon: 59.5506% (minimum 97%, Missing); duodenum: 65.4321% (minimum 99%, Missing); esophagus: 68.8312% (minimum 97%, Missing); heart muscle: 68.8312% (minimum 99%, Missing); hippocampal formation: 80.3030% (minimum 99%, Missing); hypothalamus: 79.1045% (minimum 99%, Missing); kidney: 59.5506% (minimum 99%, Missing); liver: 71.6216% (minimum 99%, Missing); lung: 62.3529% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 80.3030% (minimum 99%, Missing); pancreas: 56.3830% (minimum 99%, Missing); parathyroid gland: 56.3830% (minimum 97%, Missing); pituitary gland: 77.9412% (minimum 99%, Missing); rectum: 60.9195% (minimum 97%, Missing); retina: 51.9608% (minimum 99%, Missing); salivary gland: 65.4321% (minimum 97%, Missing); skeletal muscle: 73.6111% (minimum 99%, Missing); skin: 66.2500% (minimum 95%, Missing); small intestine: 69.7368% (minimum 99%, Missing); smooth muscle: 60.2273% (minimum 99%, Missing); spinal cord: 79.1045% (minimum 99%, Missing); spleen: 57.6087% (minimum 95%, Missing); stomach: 62.3529% (minimum 97%, Missing); thymus: 38.1295% (minimum 95%, Missing); thyroid gland: 52.4752% (minimum 95%, Missing); tongue: 60.2273% (minimum 97%, Missing); urinary bladder: 67.0886% (minimum 97%, Missing)",-0.568705,-0.47,-0.674524,0,80,unavailable,11.5,5.3,8.6,"bone marrow: 11.5 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); retina: 4.9 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188295,ZNF669,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.6279% (minimum 65%, Missing); adrenal gland: 74.6479% (minimum 75%, Missing); bone marrow: 31.5476% (minimum 75%, Missing); cerebellum: 64.6341% (minimum 75%, Missing); cerebral cortex: 62.3529% (minimum 75%, Missing); choroid plexus: 74.6479% (minimum 75%, Missing); colon: 59.5506% (minimum 70%, Missing); duodenum: 65.4321% (minimum 75%, Missing); esophagus: 68.8312% (minimum 70%, Missing); heart muscle: 68.8312% (minimum 75%, Missing); kidney: 59.5506% (minimum 75%, Missing); liver: 71.6216% (minimum 75%, Missing); lung: 62.3529% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 56.3830% (minimum 75%, Missing); parathyroid gland: 56.3830% (minimum 70%, Missing); rectum: 60.9195% (minimum 70%, Missing); retina: 51.9608% (minimum 75%, Missing); salivary gland: 65.4321% (minimum 70%, Missing); skeletal muscle: 73.6111% (minimum 75%, Missing); small intestine: 69.7368% (minimum 75%, Missing); smooth muscle: 60.2273% (minimum 75%, Missing); spleen: 57.6087% (minimum 65%, Missing); stomach: 62.3529% (minimum 70%, Missing); thymus: 38.1295% (minimum 65%, Missing); thyroid gland: 52.4752% (minimum 65%, Missing); tongue: 60.2273% (minimum 70%, Missing); urinary bladder: 67.0886% (minimum 70%, Missing)",-0.268705,-0.2,-0.434524,0,80,unavailable,11.5,5.3,8.6,"bone marrow: 11.5 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); retina: 4.9 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188295,ZNF669,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.6279% (minimum 65%, Missing); adrenal gland: 74.6479% (minimum 75%, Missing); bone marrow: 31.5476% (minimum 75%, Missing); cerebellum: 64.6341% (minimum 75%, Missing); cerebral cortex: 62.3529% (minimum 75%, Missing); choroid plexus: 74.6479% (minimum 75%, Missing); colon: 59.5506% (minimum 70%, Missing); duodenum: 65.4321% (minimum 75%, Missing); esophagus: 68.8312% (minimum 70%, Missing); heart muscle: 68.8312% (minimum 75%, Missing); kidney: 59.5506% (minimum 75%, Missing); liver: 71.6216% (minimum 75%, Missing); lung: 62.3529% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 56.3830% (minimum 75%, Missing); parathyroid gland: 56.3830% (minimum 70%, Missing); rectum: 60.9195% (minimum 70%, Missing); retina: 51.9608% (minimum 75%, Missing); salivary gland: 65.4321% (minimum 70%, Missing); skeletal muscle: 73.6111% (minimum 75%, Missing); small intestine: 69.7368% (minimum 75%, Missing); smooth muscle: 60.2273% (minimum 75%, Missing); spleen: 57.6087% (minimum 65%, Missing); stomach: 62.3529% (minimum 70%, Missing); thymus: 38.1295% (minimum 65%, Missing); thyroid gland: 52.4752% (minimum 65%, Missing); tongue: 60.2273% (minimum 70%, Missing); urinary bladder: 67.0886% (minimum 70%, Missing)",-0.268705,-0.2,-0.434524,0,80,unavailable,11.5,5.3,8.6,"bone marrow: 11.5 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); lung: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188295,ZNF669,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.6279% (minimum 65%, Missing); adrenal gland: 74.6479% (minimum 75%, Missing); bone marrow: 31.5476% (minimum 75%, Missing); cerebellum: 64.6341% (minimum 75%, Missing); cerebral cortex: 62.3529% (minimum 75%, Missing); choroid plexus: 74.6479% (minimum 75%, Missing); colon: 59.5506% (minimum 70%, Missing); duodenum: 65.4321% (minimum 75%, Missing); esophagus: 68.8312% (minimum 70%, Missing); heart muscle: 68.8312% (minimum 75%, Missing); kidney: 59.5506% (minimum 75%, Missing); liver: 71.6216% (minimum 75%, Missing); lung: 62.3529% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 56.3830% (minimum 75%, Missing); parathyroid gland: 56.3830% (minimum 70%, Missing); rectum: 60.9195% (minimum 70%, Missing); retina: 51.9608% (minimum 75%, Missing); salivary gland: 65.4321% (minimum 70%, Missing); skeletal muscle: 73.6111% (minimum 75%, Missing); small intestine: 69.7368% (minimum 75%, Missing); smooth muscle: 60.2273% (minimum 75%, Missing); spleen: 57.6087% (minimum 65%, Missing); stomach: 62.3529% (minimum 70%, Missing); thymus: 38.1295% (minimum 65%, Missing); thyroid gland: 52.4752% (minimum 65%, Missing); tongue: 60.2273% (minimum 70%, Missing); urinary bladder: 67.0886% (minimum 70%, Missing)",-0.268705,-0.2,-0.434524,0,80,unavailable,11.5,5.3,8.6,"bone marrow: 11.5 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); lung: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188295,ZNF669,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.6279% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 74.6479% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 31.5476% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.6341% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.3529% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.6479% (minimum 75%, Baseline (adaptation disabled)); colon: 59.5506% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.4321% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.8312% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.8312% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.5506% (minimum 75%, Baseline (adaptation disabled)); liver: 71.6216% (minimum 75%, Baseline (adaptation disabled)); lung: 62.3529% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 56.3830% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 56.3830% (minimum 70%, Baseline (adaptation disabled)); rectum: 60.9195% (minimum 70%, Baseline (adaptation disabled)); retina: 51.9608% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.4321% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 73.6111% (minimum 75%, Baseline (adaptation disabled)); small intestine: 69.7368% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.2273% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.6087% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.3529% (minimum 70%, Baseline (adaptation disabled)); thymus: 38.1295% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.4752% (minimum 65%, Baseline (adaptation disabled)); tongue: 60.2273% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.0886% (minimum 70%, Baseline (adaptation disabled))",-0.268705,-0.2,-0.434524,0,80,unavailable,11.5,5.3,8.6,"bone marrow: 11.5 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); lung: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188295,ZNF669,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 96.5517% (minimum 99%, Missing); colon: 90.3226% (minimum 97%, Missing); duodenum: 93.3333% (minimum 99%, Missing); rectum: 96.5517% (minimum 97%, Missing); retina: 93.3333% (minimum 99%, Missing); salivary gland: 96.5517% (minimum 97%, Missing); small intestine: 87.5000% (minimum 99%, Missing); stomach: 93.3333% (minimum 97%, Missing); tongue: 96.5517% (minimum 97%, Missing)",0.05,-0.0667742,-0.115,0,80,unavailable,0.4,0.3,0,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188306,LRRIQ4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.203226,0.125,0,80,unavailable,0.4,0.3,0,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188306,LRRIQ4,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.203226,0.125,0,80,unavailable,0.4,0.3,0,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188306,LRRIQ4,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.203226,0.125,0,80,unavailable,0.4,0.3,0,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188306,LRRIQ4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.203226,0.125,0,80,unavailable,0.4,0.3,0,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188306,LRRIQ4,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3333% (minimum 95%, Uncertain); adrenal gland: 59.7222% (minimum 99%, Missing); amygdala: 62.3188% (minimum 99%, Missing); basal ganglia: 58.9041% (minimum 99%, Missing); bone marrow: 26.2195% (minimum 99%, Missing); cerebellum: 65.1515% (minimum 99%, Missing); cerebral cortex: 56.5789% (minimum 99%, Missing); choroid plexus: 91.4894% (minimum 99%, Missing); colon: 65.1515% (minimum 97%, Missing); duodenum: 61.4286% (minimum 99%, Missing); esophagus: 50.0000% (minimum 97%, Missing); heart muscle: 61.4286% (minimum 99%, Uncertain); hippocampal formation: 59.7222% (minimum 99%, Missing); hypothalamus: 63.2353% (minimum 99%, Missing); kidney: 69.3548% (minimum 99%, Missing); liver: 70.4918% (minimum 99%, Missing); lung: 69.3548% (minimum 99%, Missing); lymph node: 43.8776% (minimum 97%, Uncertain); midbrain: 64.1791% (minimum 99%, Missing); pancreas: 67.1875% (minimum 99%, Missing); parathyroid gland: 65.1515% (minimum 97%, Missing); pituitary gland: 71.6667% (minimum 99%, Missing); rectum: 62.3188% (minimum 97%, Missing); retina: 65.1515% (minimum 99%, Missing); salivary gland: 66.1538% (minimum 97%, Missing); skeletal muscle: 33.0769% (minimum 99%, Missing); skin: 17.0635% (minimum 95%, Missing); small intestine: 70.4918% (minimum 99%, Missing); smooth muscle: 59.7222% (minimum 99%, Missing); spinal cord: 67.1875% (minimum 99%, Missing); spleen: 61.4286% (minimum 95%, Uncertain); stomach: 70.4918% (minimum 97%, Missing); thymus: 38.3929% (minimum 95%, Missing); thyroid gland: 76.7857% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 66.1538% (minimum 97%, Missing)",-0.779365,-0.531224,-0.727805,0,3,partial,12.1,5.5,20.9,"skin: 20.9 nTPM (manageable, limit 5); bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); tongue: 4.3 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188312,CENPP,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3333% (minimum 65%, Uncertain); adrenal gland: 59.7222% (minimum 75%, Missing); amygdala: 62.3188% (minimum 75%, Missing); basal ganglia: 58.9041% (minimum 75%, Missing); bone marrow: 26.2195% (minimum 75%, Missing); cerebellum: 65.1515% (minimum 75%, Missing); cerebral cortex: 56.5789% (minimum 75%, Missing); colon: 65.1515% (minimum 70%, Missing); duodenum: 61.4286% (minimum 75%, Missing); esophagus: 50.0000% (minimum 70%, Missing); heart muscle: 61.4286% (minimum 75%, Uncertain); hippocampal formation: 59.7222% (minimum 75%, Missing); hypothalamus: 63.2353% (minimum 75%, Missing); kidney: 69.3548% (minimum 75%, Missing); liver: 70.4918% (minimum 75%, Missing); lung: 69.3548% (minimum 75%, Missing); lymph node: 43.8776% (minimum 70%, Uncertain); midbrain: 64.1791% (minimum 75%, Missing); pancreas: 67.1875% (minimum 75%, Missing); parathyroid gland: 65.1515% (minimum 70%, Missing); pituitary gland: 71.6667% (minimum 75%, Missing); rectum: 62.3188% (minimum 70%, Missing); retina: 65.1515% (minimum 75%, Missing); salivary gland: 66.1538% (minimum 70%, Missing); skeletal muscle: 33.0769% (minimum 75%, Missing); skin: 17.0635% (minimum 65%, Missing); small intestine: 70.4918% (minimum 75%, Missing); smooth muscle: 59.7222% (minimum 75%, Missing); spinal cord: 67.1875% (minimum 75%, Missing); spleen: 61.4286% (minimum 65%, Uncertain); thymus: 38.3929% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 66.1538% (minimum 70%, Missing)",-0.479365,-0.261224,-0.487805,0,3,partial,12.1,5.5,20.9,"skin: 20.9 nTPM (manageable, limit 5); bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); tongue: 4.3 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188312,CENPP,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3333% (minimum 65%, Uncertain); adrenal gland: 59.7222% (minimum 75%, Missing); amygdala: 62.3188% (minimum 75%, Missing); basal ganglia: 58.9041% (minimum 75%, Missing); bone marrow: 26.2195% (minimum 75%, Missing); cerebellum: 65.1515% (minimum 75%, Missing); cerebral cortex: 56.5789% (minimum 75%, Missing); colon: 65.1515% (minimum 70%, Missing); duodenum: 61.4286% (minimum 75%, Missing); esophagus: 50.0000% (minimum 70%, Missing); heart muscle: 61.4286% (minimum 75%, Uncertain); hippocampal formation: 59.7222% (minimum 75%, Missing); hypothalamus: 63.2353% (minimum 75%, Missing); kidney: 69.3548% (minimum 75%, Missing); liver: 70.4918% (minimum 75%, Missing); lung: 69.3548% (minimum 75%, Missing); lymph node: 43.8776% (minimum 70%, Uncertain); midbrain: 64.1791% (minimum 75%, Missing); pancreas: 67.1875% (minimum 75%, Missing); parathyroid gland: 65.1515% (minimum 70%, Missing); pituitary gland: 71.6667% (minimum 75%, Missing); rectum: 62.3188% (minimum 70%, Missing); retina: 65.1515% (minimum 75%, Missing); salivary gland: 66.1538% (minimum 70%, Missing); skeletal muscle: 33.0769% (minimum 75%, Missing); skin: 17.0635% (minimum 65%, Missing); small intestine: 70.4918% (minimum 75%, Missing); smooth muscle: 59.7222% (minimum 75%, Missing); spinal cord: 67.1875% (minimum 75%, Missing); spleen: 61.4286% (minimum 65%, Uncertain); thymus: 38.3929% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 66.1538% (minimum 70%, Missing)",-0.479365,-0.261224,-0.487805,0,3,partial,12.1,5.5,20.9,"skin: 20.9 nTPM (manageable, limit 5); bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); tongue: 4.3 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188312,CENPP,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3333% (minimum 65%, Uncertain); adrenal gland: 59.7222% (minimum 75%, Missing); amygdala: 62.3188% (minimum 75%, Missing); basal ganglia: 58.9041% (minimum 75%, Missing); bone marrow: 26.2195% (minimum 75%, Missing); cerebellum: 65.1515% (minimum 75%, Missing); cerebral cortex: 56.5789% (minimum 75%, Missing); colon: 65.1515% (minimum 70%, Missing); duodenum: 61.4286% (minimum 75%, Missing); esophagus: 50.0000% (minimum 70%, Missing); heart muscle: 61.4286% (minimum 75%, Uncertain); hippocampal formation: 59.7222% (minimum 75%, Missing); hypothalamus: 63.2353% (minimum 75%, Missing); kidney: 69.3548% (minimum 75%, Missing); liver: 70.4918% (minimum 75%, Missing); lung: 69.3548% (minimum 75%, Missing); lymph node: 43.8776% (minimum 70%, Uncertain); midbrain: 64.1791% (minimum 75%, Missing); pancreas: 67.1875% (minimum 75%, Missing); parathyroid gland: 65.1515% (minimum 70%, Missing); pituitary gland: 71.6667% (minimum 75%, Missing); rectum: 62.3188% (minimum 70%, Missing); retina: 65.1515% (minimum 75%, Missing); salivary gland: 66.1538% (minimum 70%, Missing); skeletal muscle: 33.0769% (minimum 75%, Missing); skin: 17.0635% (minimum 65%, Missing); small intestine: 70.4918% (minimum 75%, Missing); smooth muscle: 59.7222% (minimum 75%, Missing); spinal cord: 67.1875% (minimum 75%, Missing); spleen: 61.4286% (minimum 65%, Uncertain); thymus: 38.3929% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 66.1538% (minimum 70%, Missing)",-0.479365,-0.261224,-0.487805,0,3,partial,12.1,5.5,20.9,"skin: 20.9 nTPM (manageable, limit 5); bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); tongue: 4.3 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188312,CENPP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3333% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 59.7222% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.3188% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.9041% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 26.2195% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.1515% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.5789% (minimum 75%, Baseline (adaptation disabled)); colon: 65.1515% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.4286% (minimum 75%, Baseline (adaptation disabled)); esophagus: 50.0000% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 61.4286% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 59.7222% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.2353% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.3548% (minimum 75%, Baseline (adaptation disabled)); liver: 70.4918% (minimum 75%, Baseline (adaptation disabled)); lung: 69.3548% (minimum 75%, Baseline (adaptation disabled)); lymph node: 43.8776% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.1791% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.1875% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.1515% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.6667% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.3188% (minimum 70%, Baseline (adaptation disabled)); retina: 65.1515% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.1538% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 33.0769% (minimum 75%, Baseline (adaptation disabled)); skin: 17.0635% (minimum 65%, Baseline (adaptation disabled)); small intestine: 70.4918% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.7222% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.1875% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.4286% (minimum 65%, Baseline (adaptation disabled)); thymus: 38.3929% (minimum 65%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 66.1538% (minimum 70%, Baseline (adaptation disabled))",-0.479365,-0.261224,-0.487805,0,3,partial,12.1,5.5,20.9,"skin: 20.9 nTPM (manageable, limit 5); bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); tongue: 4.3 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188312,CENPP,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.9130% (minimum 90%, Approved); adrenal gland: 69.8238% (minimum 99%, Missing); amygdala: 76.7554% (minimum 99%, Missing); basal ganglia: 74.5882% (minimum 99%, Missing); bone marrow: 89.0449% (minimum 99%, Missing); cerebellum: 70.7589% (minimum 99%, Missing); cerebral cortex: 79.2500% (minimum 99%, Missing); choroid plexus: 60.6119% (minimum 99%, Missing); colon: 66.3180% (minimum 97%, Missing); duodenum: 83.6412% (minimum 99%, Missing); esophagus: 81.4910% (minimum 97%, Missing); heart muscle: 62.4016% (minimum 99%, Missing); hippocampal formation: 74.2389% (minimum 99%, Missing); hypothalamus: 74.2389% (minimum 99%, Missing); kidney: 63.0219% (minimum 99%, Missing); liver: 74.5882% (minimum 99%, Missing); lung: 72.3744% (minimum 99%, Missing); lymph node: 67.0190% (minimum 97%, Missing); midbrain: 75.8373% (minimum 99%, Missing); pancreas: 75.4762% (minimum 99%, Missing); parathyroid gland: 59.5865% (minimum 97%, Missing); pituitary gland: 55.7118% (minimum 99%, Missing); rectum: 74.7642% (minimum 97%, Missing); retina: 61.5534% (minimum 99%, Missing); salivary gland: 72.5400% (minimum 97%, Missing); skeletal muscle: 87.3278% (minimum 99%, Missing); skin: 75.2969% (minimum 95%, Missing); small intestine: 68.7636% (minimum 99%, Missing); smooth muscle: 63.1474% (minimum 99%, Missing); spinal cord: 75.6563% (minimum 99%, Missing); spleen: 59.5865% (minimum 95%, Missing); stomach: 71.5576% (minimum 97%, Missing); thymus: 59.1418% (minimum 95%, Missing); thyroid gland: 62.4016% (minimum 95%, Missing); tongue: 75.6563% (minimum 97%, Missing); urinary bladder: 65.9044% (minimum 97%, Missing)",-0.358582,-0.374135,-0.432882,0,2,partial,25.2,21.5,21.9,"pituitary gland: 25.2 nTPM (vital, limit 1); thymus: 21.9 nTPM (manageable, limit 5); spleen: 21.5 nTPM (manageable, limit 5); parathyroid gland: 21.5 nTPM (protected, limit 2); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); heart muscle: 19.1 nTPM (vital, limit 1); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 2); colon: 16.1 nTPM (protected, limit 2); lymph node: 15.6 nTPM (protected, limit 2); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 10); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 2); hypothalamus: 11 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 2); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188321,ZNF559,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.8238% (minimum 75%, Missing); basal ganglia: 74.5882% (minimum 75%, Missing); cerebellum: 70.7589% (minimum 75%, Missing); choroid plexus: 60.6119% (minimum 75%, Missing); colon: 66.3180% (minimum 70%, Missing); heart muscle: 62.4016% (minimum 75%, Missing); hippocampal formation: 74.2389% (minimum 75%, Missing); hypothalamus: 74.2389% (minimum 75%, Missing); kidney: 63.0219% (minimum 75%, Missing); liver: 74.5882% (minimum 75%, Missing); lung: 72.3744% (minimum 75%, Missing); lymph node: 67.0190% (minimum 70%, Missing); parathyroid gland: 59.5865% (minimum 70%, Missing); pituitary gland: 55.7118% (minimum 75%, Missing); retina: 61.5534% (minimum 75%, Missing); small intestine: 68.7636% (minimum 75%, Missing); smooth muscle: 63.1474% (minimum 75%, Missing); spleen: 59.5865% (minimum 65%, Missing); thymus: 59.1418% (minimum 65%, Missing); thyroid gland: 62.4016% (minimum 65%, Missing); urinary bladder: 65.9044% (minimum 70%, Missing)",-0.0585821,-0.104135,-0.192882,0,2,partial,25.2,21.5,21.9,"pituitary gland: 25.2 nTPM (vital, limit 1); thymus: 21.9 nTPM (manageable, limit 5); spleen: 21.5 nTPM (manageable, limit 5); parathyroid gland: 21.5 nTPM (protected, limit 2); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); heart muscle: 19.1 nTPM (vital, limit 1); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 2); colon: 16.1 nTPM (protected, limit 2); lymph node: 15.6 nTPM (protected, limit 2); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 10); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 2); hypothalamus: 11 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 2); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188321,ZNF559,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.8238% (minimum 75%, Missing); basal ganglia: 74.5882% (minimum 75%, Missing); cerebellum: 70.7589% (minimum 75%, Missing); choroid plexus: 60.6119% (minimum 75%, Missing); colon: 66.3180% (minimum 70%, Missing); heart muscle: 62.4016% (minimum 75%, Missing); hippocampal formation: 74.2389% (minimum 75%, Missing); hypothalamus: 74.2389% (minimum 75%, Missing); kidney: 63.0219% (minimum 75%, Missing); liver: 74.5882% (minimum 75%, Missing); lung: 72.3744% (minimum 75%, Missing); lymph node: 67.0190% (minimum 70%, Missing); parathyroid gland: 59.5865% (minimum 70%, Missing); pituitary gland: 55.7118% (minimum 75%, Missing); retina: 61.5534% (minimum 75%, Missing); small intestine: 68.7636% (minimum 75%, Missing); smooth muscle: 63.1474% (minimum 75%, Missing); spleen: 59.5865% (minimum 65%, Missing); thymus: 59.1418% (minimum 65%, Missing); thyroid gland: 62.4016% (minimum 65%, Missing); urinary bladder: 65.9044% (minimum 70%, Missing)",-0.0585821,-0.104135,-0.192882,0,2,partial,25.2,21.5,21.9,"pituitary gland: 25.2 nTPM (vital, limit 1); thymus: 21.9 nTPM (manageable, limit 5); spleen: 21.5 nTPM (manageable, limit 5); parathyroid gland: 21.5 nTPM (protected, limit 3); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); heart muscle: 19.1 nTPM (vital, limit 1); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 3); colon: 16.1 nTPM (protected, limit 3); lymph node: 15.6 nTPM (protected, limit 3); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 10); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 3); hypothalamus: 11 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 3); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188321,ZNF559,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.8238% (minimum 75%, Missing); basal ganglia: 74.5882% (minimum 75%, Missing); cerebellum: 70.7589% (minimum 75%, Missing); choroid plexus: 60.6119% (minimum 75%, Missing); colon: 66.3180% (minimum 70%, Missing); heart muscle: 62.4016% (minimum 75%, Missing); hippocampal formation: 74.2389% (minimum 75%, Missing); hypothalamus: 74.2389% (minimum 75%, Missing); kidney: 63.0219% (minimum 75%, Missing); liver: 74.5882% (minimum 75%, Missing); lung: 72.3744% (minimum 75%, Missing); lymph node: 67.0190% (minimum 70%, Missing); parathyroid gland: 59.5865% (minimum 70%, Missing); pituitary gland: 55.7118% (minimum 75%, Missing); retina: 61.5534% (minimum 75%, Missing); small intestine: 68.7636% (minimum 75%, Missing); smooth muscle: 63.1474% (minimum 75%, Missing); spleen: 59.5865% (minimum 65%, Missing); thymus: 59.1418% (minimum 65%, Missing); thyroid gland: 62.4016% (minimum 65%, Missing); urinary bladder: 65.9044% (minimum 70%, Missing)",-0.0585821,-0.104135,-0.192882,0,2,partial,25.2,21.5,21.9,"pituitary gland: 25.2 nTPM (vital, limit 1); thymus: 21.9 nTPM (manageable, limit 5); spleen: 21.5 nTPM (manageable, limit 5); parathyroid gland: 21.5 nTPM (protected, limit 3); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); heart muscle: 19.1 nTPM (vital, limit 1); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 3); colon: 16.1 nTPM (protected, limit 3); lymph node: 15.6 nTPM (protected, limit 3); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 10); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 3); hypothalamus: 11 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 3); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188321,ZNF559,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.8238% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.5882% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.7589% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.6119% (minimum 75%, Baseline (adaptation disabled)); colon: 66.3180% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 62.4016% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.2389% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.2389% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.0219% (minimum 75%, Baseline (adaptation disabled)); liver: 74.5882% (minimum 75%, Baseline (adaptation disabled)); lung: 72.3744% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.0190% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 59.5865% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.7118% (minimum 75%, Baseline (adaptation disabled)); retina: 61.5534% (minimum 75%, Baseline (adaptation disabled)); small intestine: 68.7636% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.1474% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.5865% (minimum 65%, Baseline (adaptation disabled)); thymus: 59.1418% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.4016% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 65.9044% (minimum 70%, Baseline (adaptation disabled))",-0.0585821,-0.104135,-0.192882,0,2,partial,25.2,21.5,21.9,"pituitary gland: 25.2 nTPM (vital, limit 1); thymus: 21.9 nTPM (manageable, limit 5); spleen: 21.5 nTPM (manageable, limit 5); parathyroid gland: 21.5 nTPM (protected, limit 3); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); heart muscle: 19.1 nTPM (vital, limit 1); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 3); colon: 16.1 nTPM (protected, limit 3); lymph node: 15.6 nTPM (protected, limit 3); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 3); hypothalamus: 11 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 3); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188321,ZNF559,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.0835% (minimum 99%, Missing)",0.05,0.03,-0.00916514,0,1,partial,7.3,0,0,"retina: 7.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188334,BSPH1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.230835,0,1,partial,7.3,0,0,"retina: 7.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188334,BSPH1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.230835,0,1,partial,7.3,0,0,"retina: 7.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188334,BSPH1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.230835,0,1,partial,7.3,0,0,"retina: 7.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188334,BSPH1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.230835,0,1,partial,7.3,0,0,"retina: 7.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188334,BSPH1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.4545% (minimum 99%, Missing); amygdala: 90.9091% (minimum 99%, Missing); basal ganglia: 83.6653% (minimum 99%, Missing); bone marrow: 90.5172% (minimum 99%, Missing); cerebellum: 90.5172% (minimum 99%, Missing); cerebral cortex: 90.1288% (minimum 99%, Missing); choroid plexus: 95.8904% (minimum 99%, Missing); duodenum: 98.5915% (minimum 99%, Missing); esophagus: 95.0226% (minimum 97%, Missing); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 92.9204% (minimum 99%, Missing); kidney: 97.2222% (minimum 99%, Missing); liver: 97.2222% (minimum 99%, Missing); lung: 98.5915% (minimum 99%, Missing); midbrain: 96.3303% (minimum 99%, Missing); pancreas: 98.1308% (minimum 99%, Missing); pituitary gland: 95.8904% (minimum 99%, Missing); retina: 98.1308% (minimum 99%, Missing); salivary gland: 96.7742% (minimum 97%, Missing); skeletal muscle: 98.5915% (minimum 99%, Missing); small intestine: 98.1308% (minimum 99%, Missing); smooth muscle: 98.5915% (minimum 99%, Missing); spinal cord: 97.2222% (minimum 99%, Missing)",0.0177419,-0.0197738,-0.153347,0,80,unavailable,4.1,1.1,0.7,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188368,PRR19,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317742,0.250226,0.0866534,0,80,unavailable,4.1,1.1,0.7,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188368,PRR19,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317742,0.250226,0.0866534,0,80,unavailable,4.1,1.1,0.7,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188368,PRR19,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317742,0.250226,0.0866534,0,80,unavailable,4.1,1.1,0.7,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188368,PRR19,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317742,0.250226,0.0866534,0,80,unavailable,4.1,1.1,0.7,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188368,PRR19,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.00872935,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188386,PPP3R2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248729,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188386,PPP3R2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248729,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188386,PPP3R2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248729,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188386,PPP3R2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248729,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188386,PPP3R2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 95%, Missing); amygdala: 69.2308% (minimum 99%, Missing); basal ganglia: 64.2857% (minimum 99%, Missing); bone marrow: 90.0000% (minimum 99%, Missing); cerebellum: 90.0000% (minimum 99%, Missing); cerebral cortex: 36.0000% (minimum 99%, Missing); colon: 81.8182% (minimum 97%, Missing); duodenum: 90.0000% (minimum 99%, Missing); esophagus: 64.2857% (minimum 97%, Missing); heart muscle: 81.8182% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 81.8182% (minimum 99%, Missing); kidney: 81.8182% (minimum 99%, Missing); lung: 81.8182% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 90.0000% (minimum 99%, Missing); parathyroid gland: 90.0000% (minimum 97%, Missing); rectum: 64.2857% (minimum 97%, Missing); retina: 69.2308% (minimum 99%, Missing); salivary gland: 90.0000% (minimum 97%, Missing); skeletal muscle: 90.0000% (minimum 99%, Missing); skin: 81.8182% (minimum 95%, Missing); small intestine: 90.0000% (minimum 99%, Missing); smooth muscle: 50.0000% (minimum 99%, Missing); spinal cord: 90.0000% (minimum 99%, Missing); spleen: 81.8182% (minimum 95%, Missing); stomach: 90.0000% (minimum 97%, Missing); thyroid gland: 75.0000% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.45,-0.47,-0.63,0,80,unavailable,1.6,0.9,0.9,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188394,GPR21,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); amygdala: 69.2308% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); cerebral cortex: 36.0000% (minimum 75%, Missing); esophagus: 64.2857% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); rectum: 64.2857% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); smooth muscle: 50.0000% (minimum 75%, Missing)",-0.15,-0.2,-0.39,0,80,unavailable,1.6,0.9,0.9,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188394,GPR21,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); amygdala: 69.2308% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); cerebral cortex: 36.0000% (minimum 75%, Missing); esophagus: 64.2857% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); rectum: 64.2857% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); smooth muscle: 50.0000% (minimum 75%, Missing)",-0.15,-0.2,-0.39,0,80,unavailable,1.6,0.9,0.9,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188394,GPR21,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); amygdala: 69.2308% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); cerebral cortex: 36.0000% (minimum 75%, Missing); esophagus: 64.2857% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); rectum: 64.2857% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); smooth muscle: 50.0000% (minimum 75%, Missing)",-0.15,-0.2,-0.39,0,80,unavailable,1.6,0.9,0.9,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188394,GPR21,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Baseline (adaptation disabled)); amygdala: 69.2308% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.2857% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 36.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.2857% (minimum 70%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); rectum: 64.2857% (minimum 70%, Baseline (adaptation disabled)); retina: 69.2308% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 50.0000% (minimum 75%, Baseline (adaptation disabled))",-0.15,-0.2,-0.39,0,80,unavailable,1.6,0.9,0.9,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188394,GPR21,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188408,MAGEB5,admission_only,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188408,MAGEB5,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188408,MAGEB5,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188408,MAGEB5,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188408,MAGEB5,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 97.2222% (minimum 99%, Missing); cerebral cortex: 97.2222% (minimum 98%, Approved); hippocampal formation: 97.2222% (minimum 99%, Missing); hypothalamus: 97.2222% (minimum 99%, Missing); midbrain: 97.2222% (minimum 99%, Missing)",0.05,0.03,-0.0177778,0,5,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188425,NANOS2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.222222,0,5,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188425,NANOS2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.222222,0,5,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188425,NANOS2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.222222,0,5,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188425,NANOS2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.222222,0,5,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188425,NANOS2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 94.1176% (minimum 99%, Missing); cerebellum: 88.8889% (minimum 99%, Missing); cerebral cortex: 94.1176% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); hippocampal formation: 94.1176% (minimum 99%, Missing); hypothalamus: 84.2105% (minimum 99%, Missing); kidney: 94.1176% (minimum 99%, Missing); midbrain: 72.7273% (minimum 99%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); retina: 84.2105% (minimum 99%, Missing); salivary gland: 94.1176% (minimum 97%, Missing); skin: 16.6667% (minimum 95%, Missing); spinal cord: 88.8889% (minimum 99%, Missing); stomach: 94.1176% (minimum 97%, Missing)",-0.783333,-0.0288235,-0.262727,0,80,unavailable,0.6,0.1,8,"skin: 8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188467,SLC24A5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"midbrain: 72.7273% (minimum 75%, Missing); skin: 16.6667% (minimum 65%, Missing)",-0.483333,0.241176,-0.0227273,0,80,unavailable,0.6,0.1,8,"skin: 8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188467,SLC24A5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"midbrain: 72.7273% (minimum 75%, Missing); skin: 16.6667% (minimum 65%, Missing)",-0.483333,0.241176,-0.0227273,0,80,unavailable,0.6,0.1,8,"skin: 8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188467,SLC24A5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"midbrain: 72.7273% (minimum 75%, Missing); skin: 16.6667% (minimum 65%, Missing)",-0.483333,0.241176,-0.0227273,0,80,unavailable,0.6,0.1,8,"skin: 8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188467,SLC24A5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"midbrain: 72.7273% (minimum 75%, Baseline (adaptation disabled)); skin: 16.6667% (minimum 65%, Baseline (adaptation disabled))",-0.483333,0.241176,-0.0227273,0,80,unavailable,0.6,0.1,8,"skin: 8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188467,SLC24A5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 99%, Missing); bone marrow: 40.0000% (minimum 99%, Missing); duodenum: 50.0000% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); pancreas: 40.0000% (minimum 99%, Missing); retina: 28.5714% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 50.0000% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 50.0000% (minimum 97%, Missing)",-0.45,-0.47,-0.704286,0,80,unavailable,0.5,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188558,OR2G6,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 40.0000% (minimum 75%, Missing); duodenum: 50.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 40.0000% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); stomach: 50.0000% (minimum 70%, Missing)",-0.15,-0.2,-0.464286,0,80,unavailable,0.5,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188558,OR2G6,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 40.0000% (minimum 75%, Missing); duodenum: 50.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 40.0000% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); stomach: 50.0000% (minimum 70%, Missing)",-0.15,-0.2,-0.464286,0,80,unavailable,0.5,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188558,OR2G6,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 40.0000% (minimum 75%, Missing); duodenum: 50.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 40.0000% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); stomach: 50.0000% (minimum 70%, Missing)",-0.15,-0.2,-0.464286,0,80,unavailable,0.5,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188558,OR2G6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 40.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); pancreas: 40.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 28.5714% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); skin: 50.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 75%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 70%, Baseline (adaptation disabled))",-0.15,-0.2,-0.464286,0,80,unavailable,0.5,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188558,OR2G6,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 72.4138% (minimum 99%, Missing); lymph node: 65.6250% (minimum 97%, Missing); spleen: 80.7692% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thymus: 91.3043% (minimum 95%, Missing); urinary bladder: 95.4545% (minimum 97%, Missing)",-0.142308,-0.31375,-0.265862,0,80,unavailable,0.8,1.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188585,CLEC20A,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 72.4138% (minimum 75%, Missing); lymph node: 65.6250% (minimum 70%, Missing)",0.157692,-0.04375,-0.0258621,0,80,unavailable,0.8,1.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188585,CLEC20A,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 72.4138% (minimum 75%, Missing); lymph node: 65.6250% (minimum 70%, Missing)",0.157692,-0.04375,-0.0258621,0,80,unavailable,0.8,1.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188585,CLEC20A,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 72.4138% (minimum 75%, Missing); lymph node: 65.6250% (minimum 70%, Missing)",0.157692,-0.04375,-0.0258621,0,80,unavailable,0.8,1.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188585,CLEC20A,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 72.4138% (minimum 75%, Baseline (adaptation disabled)); lymph node: 65.6250% (minimum 70%, Baseline (adaptation disabled))",0.157692,-0.04375,-0.0258621,0,80,unavailable,0.8,1.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188585,CLEC20A,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.5882% (minimum 95%, Uncertain); adrenal gland: 95.6522% (minimum 99%, Uncertain); amygdala: 93.3333% (minimum 99%, Missing); basal ganglia: 93.9024% (minimum 99%, Missing); bone marrow: 89.5349% (minimum 99%, Uncertain); cerebellum: 82.3529% (minimum 99%, Missing); cerebral cortex: 92.7711% (minimum 99%, Uncertain); choroid plexus: 26.5060% (minimum 99%, Missing); colon: 93.3333% (minimum 97%, Missing); duodenum: 95.6522% (minimum 99%, Missing); esophagus: 94.4785% (minimum 97%, Missing); heart muscle: 91.6667% (minimum 99%, Uncertain); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 92.7711% (minimum 99%, Missing); kidney: 94.4785% (minimum 99%, Missing); liver: 94.4785% (minimum 99%, Uncertain); lung: 86.0335% (minimum 99%, Uncertain); lymph node: 90.0585% (minimum 97%, Uncertain); midbrain: 92.7711% (minimum 99%, Missing); pancreas: 91.1243% (minimum 99%, Missing); parathyroid gland: 56.6176% (minimum 97%, Missing); pituitary gland: 87.0056% (minimum 99%, Missing); rectum: 95.6522% (minimum 97%, Missing); retina: 27.5000% (minimum 99%, Missing); salivary gland: 90.5882% (minimum 97%, Missing); skeletal muscle: 89.5349% (minimum 99%, Uncertain); skin: 76.6169% (minimum 95%, Uncertain); small intestine: 93.9024% (minimum 99%, Missing); smooth muscle: 91.6667% (minimum 99%, Uncertain); spinal cord: 90.0585% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Uncertain); stomach: 94.4785% (minimum 97%, Missing); thymus: 93.9024% (minimum 95%, Missing); thyroid gland: 37.2881% (minimum 95%, Uncertain); tongue: 91.1243% (minimum 97%, Missing); urinary bladder: 93.9024% (minimum 97%, Missing)",-0.577119,-0.403824,-0.72494,0,1,partial,42.7,11.8,25.9,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (manageable, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 2); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188687,SLC4A5,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 26.5060% (minimum 75%, Missing); parathyroid gland: 56.6176% (minimum 70%, Missing); retina: 27.5000% (minimum 75%, Missing); thyroid gland: 37.2881% (minimum 65%, Uncertain)",-0.277119,-0.133824,-0.48494,0,1,partial,42.7,11.8,25.9,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (manageable, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 2); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188687,SLC4A5,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 26.5060% (minimum 75%, Missing); parathyroid gland: 56.6176% (minimum 70%, Missing); retina: 27.5000% (minimum 75%, Missing); thyroid gland: 37.2881% (minimum 65%, Uncertain)",-0.277119,-0.133824,-0.48494,0,1,partial,42.7,11.8,25.9,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (manageable, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 3); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188687,SLC4A5,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 26.5060% (minimum 75%, Missing); parathyroid gland: 56.6176% (minimum 70%, Missing); retina: 27.5000% (minimum 75%, Missing); thyroid gland: 37.2881% (minimum 65%, Uncertain)",-0.277119,-0.133824,-0.48494,0,1,partial,42.7,11.8,25.9,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (manageable, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 3); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188687,SLC4A5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 26.5060% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 56.6176% (minimum 70%, Baseline (adaptation disabled)); retina: 27.5000% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 37.2881% (minimum 65%, Baseline (adaptation disabled))",-0.277119,-0.133824,-0.48494,0,1,partial,42.7,11.8,25.9,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (manageable, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 3); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188687,SLC4A5,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188691,OR56A5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188691,OR56A5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188691,OR56A5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188691,OR56A5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188691,OR56A5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.2963% (minimum 99%, Missing); colon: 78.7879% (minimum 97%, Missing); pancreas: 98.1132% (minimum 99%, Missing); parathyroid gland: 96.2963% (minimum 97%, Missing); pituitary gland: 94.5455% (minimum 99%, Missing); rectum: 85.2459% (minimum 97%, Missing); retina: 89.6552% (minimum 99%, Missing); small intestine: 96.2963% (minimum 99%, Missing); stomach: 67.5325% (minimum 97%, Missing); urinary bladder: 96.2963% (minimum 97%, Missing)",0.012963,-0.294675,-0.0934483,0,80,unavailable,0.6,2.5,0.2,"stomach: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188738,FSIP2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 67.5325% (minimum 70%, Missing)",0.312963,-0.0246753,0.146552,0,80,unavailable,0.6,2.5,0.2,"stomach: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188738,FSIP2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"stomach: 67.5325% (minimum 70%, Missing)",0.312963,-0.0246753,0.146552,0,80,unavailable,0.6,2.5,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188738,FSIP2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"stomach: 67.5325% (minimum 70%, Missing)",0.312963,-0.0246753,0.146552,0,80,unavailable,0.6,2.5,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188738,FSIP2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"stomach: 67.5325% (minimum 70%, Baseline (adaptation disabled))",0.312963,-0.0246753,0.146552,0,80,unavailable,0.6,2.5,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188738,FSIP2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6923% (minimum 95%, Missing); adrenal gland: 67.6471% (minimum 99%, Missing); amygdala: 63.4969% (minimum 99%, Missing); basal ganglia: 66.1342% (minimum 99%, Missing); bone marrow: 37.1634% (minimum 99%, Missing); cerebellum: 73.9286% (minimum 99%, Missing); cerebral cortex: 63.1098% (minimum 99%, Missing); choroid plexus: 58.3099% (minimum 99%, Missing); colon: 63.1098% (minimum 97%, Missing); duodenum: 54.3307% (minimum 99%, Missing); esophagus: 60.7038% (minimum 97%, Missing); heart muscle: 57.9832% (minimum 99%, Missing); hippocampal formation: 65.2997% (minimum 99%, Missing); hypothalamus: 64.0867% (minimum 99%, Missing); kidney: 55.6452% (minimum 99%, Missing); liver: 58.9744% (minimum 99%, Missing); lung: 64.2857% (minimum 99%, Missing); lymph node: 47.8060% (minimum 97%, Missing); midbrain: 61.6071% (minimum 99%, Missing); pancreas: 61.9760% (minimum 99%, Missing); parathyroid gland: 69.6970% (minimum 97%, Missing); pituitary gland: 70.8904% (minimum 99%, Missing); rectum: 60.3499% (minimum 97%, Missing); retina: 77.2388% (minimum 99%, Missing); salivary gland: 51.6209% (minimum 97%, Missing); skeletal muscle: 52.1411% (minimum 99%, Missing); skin: 53.7662% (minimum 95%, Missing); small intestine: 57.3407% (minimum 99%, Missing); smooth muscle: 64.8903% (minimum 99%, Missing); spinal cord: 59.1429% (minimum 99%, Missing); spleen: 62.5378% (minimum 95%, Missing); stomach: 59.8266% (minimum 97%, Missing); thymus: 56.5574% (minimum 95%, Missing); thyroid gland: 57.6602% (minimum 95%, Missing); tongue: 64.4860% (minimum 97%, Missing); urinary bladder: 57.8212% (minimum 97%, Missing)",-0.412338,-0.49194,-0.618366,0,6,partial,35,22.6,17.8,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 2); salivary gland: 19.4 nTPM (protected, limit 2); skeletal muscle: 19 nTPM (vital, limit 1); skin: 17.8 nTPM (manageable, limit 5); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); urinary bladder: 15.1 nTPM (protected, limit 2); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 2); rectum: 13.6 nTPM (protected, limit 2); esophagus: 13.4 nTPM (protected, limit 2); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 2); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188739,RBM34,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6923% (minimum 65%, Missing); adrenal gland: 67.6471% (minimum 75%, Missing); amygdala: 63.4969% (minimum 75%, Missing); basal ganglia: 66.1342% (minimum 75%, Missing); bone marrow: 37.1634% (minimum 75%, Missing); cerebellum: 73.9286% (minimum 75%, Missing); cerebral cortex: 63.1098% (minimum 75%, Missing); choroid plexus: 58.3099% (minimum 75%, Missing); colon: 63.1098% (minimum 70%, Missing); duodenum: 54.3307% (minimum 75%, Missing); esophagus: 60.7038% (minimum 70%, Missing); heart muscle: 57.9832% (minimum 75%, Missing); hippocampal formation: 65.2997% (minimum 75%, Missing); hypothalamus: 64.0867% (minimum 75%, Missing); kidney: 55.6452% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Missing); lung: 64.2857% (minimum 75%, Missing); lymph node: 47.8060% (minimum 70%, Missing); midbrain: 61.6071% (minimum 75%, Missing); pancreas: 61.9760% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); pituitary gland: 70.8904% (minimum 75%, Missing); rectum: 60.3499% (minimum 70%, Missing); salivary gland: 51.6209% (minimum 70%, Missing); skeletal muscle: 52.1411% (minimum 75%, Missing); skin: 53.7662% (minimum 65%, Missing); small intestine: 57.3407% (minimum 75%, Missing); smooth muscle: 64.8903% (minimum 75%, Missing); spinal cord: 59.1429% (minimum 75%, Missing); spleen: 62.5378% (minimum 65%, Missing); stomach: 59.8266% (minimum 70%, Missing); thymus: 56.5574% (minimum 65%, Missing); thyroid gland: 57.6602% (minimum 65%, Missing); tongue: 64.4860% (minimum 70%, Missing); urinary bladder: 57.8212% (minimum 70%, Missing)",-0.112338,-0.22194,-0.378366,0,6,partial,35,22.6,17.8,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 2); salivary gland: 19.4 nTPM (protected, limit 2); skeletal muscle: 19 nTPM (vital, limit 1); skin: 17.8 nTPM (manageable, limit 5); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); urinary bladder: 15.1 nTPM (protected, limit 2); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 2); rectum: 13.6 nTPM (protected, limit 2); esophagus: 13.4 nTPM (protected, limit 2); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 2); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188739,RBM34,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6923% (minimum 65%, Missing); adrenal gland: 67.6471% (minimum 75%, Missing); amygdala: 63.4969% (minimum 75%, Missing); basal ganglia: 66.1342% (minimum 75%, Missing); bone marrow: 37.1634% (minimum 75%, Missing); cerebellum: 73.9286% (minimum 75%, Missing); cerebral cortex: 63.1098% (minimum 75%, Missing); choroid plexus: 58.3099% (minimum 75%, Missing); colon: 63.1098% (minimum 70%, Missing); duodenum: 54.3307% (minimum 75%, Missing); esophagus: 60.7038% (minimum 70%, Missing); heart muscle: 57.9832% (minimum 75%, Missing); hippocampal formation: 65.2997% (minimum 75%, Missing); hypothalamus: 64.0867% (minimum 75%, Missing); kidney: 55.6452% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Missing); lung: 64.2857% (minimum 75%, Missing); lymph node: 47.8060% (minimum 70%, Missing); midbrain: 61.6071% (minimum 75%, Missing); pancreas: 61.9760% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); pituitary gland: 70.8904% (minimum 75%, Missing); rectum: 60.3499% (minimum 70%, Missing); salivary gland: 51.6209% (minimum 70%, Missing); skeletal muscle: 52.1411% (minimum 75%, Missing); skin: 53.7662% (minimum 65%, Missing); small intestine: 57.3407% (minimum 75%, Missing); smooth muscle: 64.8903% (minimum 75%, Missing); spinal cord: 59.1429% (minimum 75%, Missing); spleen: 62.5378% (minimum 65%, Missing); stomach: 59.8266% (minimum 70%, Missing); thymus: 56.5574% (minimum 65%, Missing); thyroid gland: 57.6602% (minimum 65%, Missing); tongue: 64.4860% (minimum 70%, Missing); urinary bladder: 57.8212% (minimum 70%, Missing)",-0.112338,-0.22194,-0.378366,0,6,partial,35,22.6,17.8,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 3); salivary gland: 19.4 nTPM (protected, limit 3); skeletal muscle: 19 nTPM (vital, limit 1); skin: 17.8 nTPM (manageable, limit 5); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); urinary bladder: 15.1 nTPM (protected, limit 3); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 3); rectum: 13.6 nTPM (protected, limit 3); esophagus: 13.4 nTPM (protected, limit 3); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 3); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 3); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 3); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188739,RBM34,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6923% (minimum 65%, Missing); adrenal gland: 67.6471% (minimum 75%, Missing); amygdala: 63.4969% (minimum 75%, Missing); basal ganglia: 66.1342% (minimum 75%, Missing); bone marrow: 37.1634% (minimum 75%, Missing); cerebellum: 73.9286% (minimum 75%, Missing); cerebral cortex: 63.1098% (minimum 75%, Missing); choroid plexus: 58.3099% (minimum 75%, Missing); colon: 63.1098% (minimum 70%, Missing); duodenum: 54.3307% (minimum 75%, Missing); esophagus: 60.7038% (minimum 70%, Missing); heart muscle: 57.9832% (minimum 75%, Missing); hippocampal formation: 65.2997% (minimum 75%, Missing); hypothalamus: 64.0867% (minimum 75%, Missing); kidney: 55.6452% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Missing); lung: 64.2857% (minimum 75%, Missing); lymph node: 47.8060% (minimum 70%, Missing); midbrain: 61.6071% (minimum 75%, Missing); pancreas: 61.9760% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); pituitary gland: 70.8904% (minimum 75%, Missing); rectum: 60.3499% (minimum 70%, Missing); salivary gland: 51.6209% (minimum 70%, Missing); skeletal muscle: 52.1411% (minimum 75%, Missing); skin: 53.7662% (minimum 65%, Missing); small intestine: 57.3407% (minimum 75%, Missing); smooth muscle: 64.8903% (minimum 75%, Missing); spinal cord: 59.1429% (minimum 75%, Missing); spleen: 62.5378% (minimum 65%, Missing); stomach: 59.8266% (minimum 70%, Missing); thymus: 56.5574% (minimum 65%, Missing); thyroid gland: 57.6602% (minimum 65%, Missing); tongue: 64.4860% (minimum 70%, Missing); urinary bladder: 57.8212% (minimum 70%, Missing)",-0.112338,-0.22194,-0.378366,0,6,partial,35,22.6,17.8,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 3); salivary gland: 19.4 nTPM (protected, limit 3); skeletal muscle: 19 nTPM (vital, limit 1); skin: 17.8 nTPM (manageable, limit 5); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); urinary bladder: 15.1 nTPM (protected, limit 3); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 3); rectum: 13.6 nTPM (protected, limit 3); esophagus: 13.4 nTPM (protected, limit 3); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 3); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 3); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 3); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188739,RBM34,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6923% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 67.6471% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.4969% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.1342% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 37.1634% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.9286% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.1098% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.3099% (minimum 75%, Baseline (adaptation disabled)); colon: 63.1098% (minimum 70%, Baseline (adaptation disabled)); duodenum: 54.3307% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.7038% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 57.9832% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.2997% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.0867% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.6452% (minimum 75%, Baseline (adaptation disabled)); liver: 58.9744% (minimum 75%, Baseline (adaptation disabled)); lung: 64.2857% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.8060% (minimum 70%, Baseline (adaptation disabled)); midbrain: 61.6071% (minimum 75%, Baseline (adaptation disabled)); pancreas: 61.9760% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.6970% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.8904% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.3499% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 51.6209% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 52.1411% (minimum 75%, Baseline (adaptation disabled)); skin: 53.7662% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.3407% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.8903% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.1429% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.5378% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.8266% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.5574% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.6602% (minimum 65%, Baseline (adaptation disabled)); tongue: 64.4860% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 57.8212% (minimum 70%, Baseline (adaptation disabled))",-0.112338,-0.22194,-0.378366,0,6,partial,35,22.6,17.8,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 3); salivary gland: 19.4 nTPM (protected, limit 3); skeletal muscle: 19 nTPM (vital, limit 1); skin: 17.8 nTPM (manageable, limit 5); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); urinary bladder: 15.1 nTPM (protected, limit 3); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 3); rectum: 13.6 nTPM (protected, limit 3); esophagus: 13.4 nTPM (protected, limit 3); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 3); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 3); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 3); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188739,RBM34,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188782,CATSPER4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188782,CATSPER4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188782,CATSPER4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188782,CATSPER4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.231982,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188782,CATSPER4,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188784,PLA2G2E,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188784,PLA2G2E,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188784,PLA2G2E,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188784,PLA2G2E,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188784,PLA2G2E,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0356% (minimum 95%, Uncertain); adrenal gland: 64.3243% (minimum 99%, Missing); amygdala: 75.3165% (minimum 99%, Missing); basal ganglia: 73.4568% (minimum 99%, Missing); bone marrow: 31.4815% (minimum 99%, Uncertain); cerebellum: 53.1250% (minimum 99%, Missing); cerebral cortex: 68.3908% (minimum 99%, Missing); choroid plexus: 58.6207% (minimum 99%, Missing); colon: 55.3488% (minimum 97%, Missing); duodenum: 64.3243% (minimum 99%, Missing); esophagus: 60.4061% (minimum 97%, Missing); heart muscle: 52.6549% (minimum 99%, Missing); hippocampal formation: 73.4568% (minimum 99%, Missing); hypothalamus: 74.3750% (minimum 99%, Missing); kidney: 65.3846% (minimum 99%, Missing); liver: 64.3243% (minimum 99%, Missing); lung: 50.6383% (minimum 99%, Missing); lymph node: 33.9031% (minimum 97%, Missing); midbrain: 76.2821% (minimum 99%, Missing); pancreas: 64.3243% (minimum 99%, Missing); parathyroid gland: 58.9109% (minimum 97%, Missing); pituitary gland: 63.2979% (minimum 99%, Missing); rectum: 60.1010% (minimum 97%, Missing); retina: 49.3776% (minimum 99%, Missing); salivary gland: 63.2979% (minimum 97%, Missing); skeletal muscle: 61.9792% (minimum 99%, Missing); skin: 54.3379% (minimum 95%, Missing); small intestine: 45.5939% (minimum 99%, Missing); smooth muscle: 51.5152% (minimum 99%, Missing); spinal cord: 72.1212% (minimum 99%, Missing); spleen: 39.2739% (minimum 95%, Missing); stomach: 62.9630% (minimum 97%, Missing); thymus: 47.7912% (minimum 95%, Missing); thyroid gland: 51.0730% (minimum 95%, Missing); tongue: 69.1860% (minimum 97%, Missing); urinary bladder: 59.5000% (minimum 97%, Missing)",-0.557261,-0.630969,-0.675185,0,3,partial,25.9,23.2,18.4,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 2); spleen: 18.4 nTPM (manageable, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); thymus: 13 nTPM (manageable, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); skin: 10 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 2); urinary bladder: 8.1 nTPM (protected, limit 2); rectum: 7.9 nTPM (protected, limit 2); esophagus: 7.8 nTPM (protected, limit 2); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); pituitary gland: 6.9 nTPM (vital, limit 1); salivary gland: 6.9 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188785,ZNF548,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0356% (minimum 65%, Uncertain); adrenal gland: 64.3243% (minimum 75%, Missing); basal ganglia: 73.4568% (minimum 75%, Missing); bone marrow: 31.4815% (minimum 75%, Uncertain); cerebellum: 53.1250% (minimum 75%, Missing); cerebral cortex: 68.3908% (minimum 75%, Missing); choroid plexus: 58.6207% (minimum 75%, Missing); colon: 55.3488% (minimum 70%, Missing); duodenum: 64.3243% (minimum 75%, Missing); esophagus: 60.4061% (minimum 70%, Missing); heart muscle: 52.6549% (minimum 75%, Missing); hippocampal formation: 73.4568% (minimum 75%, Missing); hypothalamus: 74.3750% (minimum 75%, Missing); kidney: 65.3846% (minimum 75%, Missing); liver: 64.3243% (minimum 75%, Missing); lung: 50.6383% (minimum 75%, Missing); lymph node: 33.9031% (minimum 70%, Missing); pancreas: 64.3243% (minimum 75%, Missing); parathyroid gland: 58.9109% (minimum 70%, Missing); pituitary gland: 63.2979% (minimum 75%, Missing); rectum: 60.1010% (minimum 70%, Missing); retina: 49.3776% (minimum 75%, Missing); salivary gland: 63.2979% (minimum 70%, Missing); skeletal muscle: 61.9792% (minimum 75%, Missing); skin: 54.3379% (minimum 65%, Missing); small intestine: 45.5939% (minimum 75%, Missing); smooth muscle: 51.5152% (minimum 75%, Missing); spinal cord: 72.1212% (minimum 75%, Missing); spleen: 39.2739% (minimum 65%, Missing); stomach: 62.9630% (minimum 70%, Missing); thymus: 47.7912% (minimum 65%, Missing); thyroid gland: 51.0730% (minimum 65%, Missing); tongue: 69.1860% (minimum 70%, Missing); urinary bladder: 59.5000% (minimum 70%, Missing)",-0.257261,-0.360969,-0.435185,0,3,partial,25.9,23.2,18.4,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 2); spleen: 18.4 nTPM (manageable, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); thymus: 13 nTPM (manageable, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); skin: 10 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 2); urinary bladder: 8.1 nTPM (protected, limit 2); rectum: 7.9 nTPM (protected, limit 2); esophagus: 7.8 nTPM (protected, limit 2); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); pituitary gland: 6.9 nTPM (vital, limit 1); salivary gland: 6.9 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188785,ZNF548,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0356% (minimum 65%, Uncertain); adrenal gland: 64.3243% (minimum 75%, Missing); basal ganglia: 73.4568% (minimum 75%, Missing); bone marrow: 31.4815% (minimum 75%, Uncertain); cerebellum: 53.1250% (minimum 75%, Missing); cerebral cortex: 68.3908% (minimum 75%, Missing); choroid plexus: 58.6207% (minimum 75%, Missing); colon: 55.3488% (minimum 70%, Missing); duodenum: 64.3243% (minimum 75%, Missing); esophagus: 60.4061% (minimum 70%, Missing); heart muscle: 52.6549% (minimum 75%, Missing); hippocampal formation: 73.4568% (minimum 75%, Missing); hypothalamus: 74.3750% (minimum 75%, Missing); kidney: 65.3846% (minimum 75%, Missing); liver: 64.3243% (minimum 75%, Missing); lung: 50.6383% (minimum 75%, Missing); lymph node: 33.9031% (minimum 70%, Missing); pancreas: 64.3243% (minimum 75%, Missing); parathyroid gland: 58.9109% (minimum 70%, Missing); pituitary gland: 63.2979% (minimum 75%, Missing); rectum: 60.1010% (minimum 70%, Missing); retina: 49.3776% (minimum 75%, Missing); salivary gland: 63.2979% (minimum 70%, Missing); skeletal muscle: 61.9792% (minimum 75%, Missing); skin: 54.3379% (minimum 65%, Missing); small intestine: 45.5939% (minimum 75%, Missing); smooth muscle: 51.5152% (minimum 75%, Missing); spinal cord: 72.1212% (minimum 75%, Missing); spleen: 39.2739% (minimum 65%, Missing); stomach: 62.9630% (minimum 70%, Missing); thymus: 47.7912% (minimum 65%, Missing); thyroid gland: 51.0730% (minimum 65%, Missing); tongue: 69.1860% (minimum 70%, Missing); urinary bladder: 59.5000% (minimum 70%, Missing)",-0.257261,-0.360969,-0.435185,0,3,partial,25.9,23.2,18.4,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 3); spleen: 18.4 nTPM (manageable, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); thymus: 13 nTPM (manageable, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); skin: 10 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 3); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 3); urinary bladder: 8.1 nTPM (protected, limit 3); rectum: 7.9 nTPM (protected, limit 3); esophagus: 7.8 nTPM (protected, limit 3); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 3); pituitary gland: 6.9 nTPM (vital, limit 1); salivary gland: 6.9 nTPM (protected, limit 3); liver: 6.6 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188785,ZNF548,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0356% (minimum 65%, Uncertain); adrenal gland: 64.3243% (minimum 75%, Missing); basal ganglia: 73.4568% (minimum 75%, Missing); bone marrow: 31.4815% (minimum 75%, Uncertain); cerebellum: 53.1250% (minimum 75%, Missing); cerebral cortex: 68.3908% (minimum 75%, Missing); choroid plexus: 58.6207% (minimum 75%, Missing); colon: 55.3488% (minimum 70%, Missing); duodenum: 64.3243% (minimum 75%, Missing); esophagus: 60.4061% (minimum 70%, Missing); heart muscle: 52.6549% (minimum 75%, Missing); hippocampal formation: 73.4568% (minimum 75%, Missing); hypothalamus: 74.3750% (minimum 75%, Missing); kidney: 65.3846% (minimum 75%, Missing); liver: 64.3243% (minimum 75%, Missing); lung: 50.6383% (minimum 75%, Missing); lymph node: 33.9031% (minimum 70%, Missing); pancreas: 64.3243% (minimum 75%, Missing); parathyroid gland: 58.9109% (minimum 70%, Missing); pituitary gland: 63.2979% (minimum 75%, Missing); rectum: 60.1010% (minimum 70%, Missing); retina: 49.3776% (minimum 75%, Missing); salivary gland: 63.2979% (minimum 70%, Missing); skeletal muscle: 61.9792% (minimum 75%, Missing); skin: 54.3379% (minimum 65%, Missing); small intestine: 45.5939% (minimum 75%, Missing); smooth muscle: 51.5152% (minimum 75%, Missing); spinal cord: 72.1212% (minimum 75%, Missing); spleen: 39.2739% (minimum 65%, Missing); stomach: 62.9630% (minimum 70%, Missing); thymus: 47.7912% (minimum 65%, Missing); thyroid gland: 51.0730% (minimum 65%, Missing); tongue: 69.1860% (minimum 70%, Missing); urinary bladder: 59.5000% (minimum 70%, Missing)",-0.257261,-0.360969,-0.435185,0,3,partial,25.9,23.2,18.4,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 3); spleen: 18.4 nTPM (manageable, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); thymus: 13 nTPM (manageable, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); skin: 10 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 3); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 3); urinary bladder: 8.1 nTPM (protected, limit 3); rectum: 7.9 nTPM (protected, limit 3); esophagus: 7.8 nTPM (protected, limit 3); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 3); pituitary gland: 6.9 nTPM (vital, limit 1); salivary gland: 6.9 nTPM (protected, limit 3); liver: 6.6 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188785,ZNF548,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0356% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 64.3243% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.4568% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 31.4815% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 53.1250% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.3908% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.6207% (minimum 75%, Baseline (adaptation disabled)); colon: 55.3488% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.3243% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.4061% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.6549% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.4568% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.3750% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.3846% (minimum 75%, Baseline (adaptation disabled)); liver: 64.3243% (minimum 75%, Baseline (adaptation disabled)); lung: 50.6383% (minimum 75%, Baseline (adaptation disabled)); lymph node: 33.9031% (minimum 70%, Baseline (adaptation disabled)); pancreas: 64.3243% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.9109% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.2979% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.1010% (minimum 70%, Baseline (adaptation disabled)); retina: 49.3776% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.2979% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 61.9792% (minimum 75%, Baseline (adaptation disabled)); skin: 54.3379% (minimum 65%, Baseline (adaptation disabled)); small intestine: 45.5939% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 51.5152% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.1212% (minimum 75%, Baseline (adaptation disabled)); spleen: 39.2739% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.9630% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.7912% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 51.0730% (minimum 65%, Baseline (adaptation disabled)); tongue: 69.1860% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 59.5000% (minimum 70%, Baseline (adaptation disabled))",-0.257261,-0.360969,-0.435185,0,3,partial,25.9,23.2,18.4,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 3); spleen: 18.4 nTPM (manageable, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); thymus: 13 nTPM (manageable, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); skin: 10 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 3); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 3); urinary bladder: 8.1 nTPM (protected, limit 3); rectum: 7.9 nTPM (protected, limit 3); esophagus: 7.8 nTPM (protected, limit 3); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 3); pituitary gland: 6.9 nTPM (vital, limit 1); salivary gland: 6.9 nTPM (protected, limit 3); liver: 6.6 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188785,ZNF548,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.0291618,0.01,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188800,TMCO2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299162,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188800,TMCO2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299162,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188800,TMCO2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299162,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188800,TMCO2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.299162,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188800,TMCO2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.8085% (minimum 99%, Missing); basal ganglia: 97.8495% (minimum 99%, Missing); bone marrow: 95.7895% (minimum 99%, Missing); cerebral cortex: 93.8144% (minimum 99%, Missing); duodenum: 98.9130% (minimum 99%, Missing); hippocampal formation: 96.8085% (minimum 99%, Missing); hypothalamus: 93.8144% (minimum 99%, Missing); liver: 98.9130% (minimum 99%, Missing); lung: 97.8495% (minimum 99%, Missing); lymph node: 84.2593% (minimum 97%, Missing); midbrain: 91.9192% (minimum 99%, Missing); pituitary gland: 90.0990% (minimum 99%, Missing); retina: 90.0990% (minimum 99%, Missing); small intestine: 89.2157% (minimum 99%, Missing); spleen: 89.2157% (minimum 95%, Missing); thymus: 91.9192% (minimum 95%, Missing)",-0.0578431,-0.127407,-0.0978431,0,80,unavailable,1.1,1.7,1.1,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188848,BEND4,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.242157,0.142593,0.142157,0,80,unavailable,1.1,1.7,1.1,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188848,BEND4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.242157,0.142593,0.142157,0,80,unavailable,1.1,1.7,1.1,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188848,BEND4,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.242157,0.142593,0.142157,0,80,unavailable,1.1,1.7,1.1,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188848,BEND4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.242157,0.142593,0.142157,0,80,unavailable,1.1,1.7,1.1,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188848,BEND4,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 64.7059% (minimum 95%, Missing); adrenal gland: 84.6154% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 78.5714% (minimum 99%, Missing); cerebellum: 84.6154% (minimum 99%, Missing); cerebral cortex: 84.6154% (minimum 99%, Missing); choroid plexus: 91.6667% (minimum 99%, Missing); colon: 68.7500% (minimum 97%, Missing); duodenum: 84.6154% (minimum 99%, Missing); esophagus: 73.3333% (minimum 97%, Missing); heart muscle: 64.7059% (minimum 99%, Missing); hippocampal formation: 84.6154% (minimum 99%, Missing); hypothalamus: 91.6667% (minimum 99%, Missing); kidney: 84.6154% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Missing); lung: 91.6667% (minimum 99%, Missing); lymph node: 91.6667% (minimum 97%, Missing); midbrain: 91.6667% (minimum 99%, Missing); pancreas: 73.3333% (minimum 99%, Missing); pituitary gland: 68.7500% (minimum 99%, Missing); rectum: 91.6667% (minimum 97%, Missing); retina: 57.8947% (minimum 99%, Missing); salivary gland: 84.6154% (minimum 97%, Missing); skeletal muscle: 61.1111% (minimum 99%, Missing); skin: 68.7500% (minimum 95%, Missing); small intestine: 91.6667% (minimum 99%, Missing); smooth muscle: 84.6154% (minimum 99%, Missing); spleen: 84.6154% (minimum 95%, Missing); stomach: 84.6154% (minimum 97%, Missing); thyroid gland: 78.5714% (minimum 95%, Missing); tongue: 91.6667% (minimum 97%, Missing); urinary bladder: 61.1111% (minimum 97%, Missing)",-0.302941,-0.358889,-0.411053,0,80,unavailable,0.8,0.7,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188859,FAM78B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 64.7059% (minimum 65%, Missing); colon: 68.7500% (minimum 70%, Missing); heart muscle: 64.7059% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); pancreas: 73.3333% (minimum 75%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); retina: 57.8947% (minimum 75%, Missing); skeletal muscle: 61.1111% (minimum 75%, Missing); urinary bladder: 61.1111% (minimum 70%, Missing)",-0.00294118,-0.0888889,-0.171053,0,80,unavailable,0.8,0.7,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188859,FAM78B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 64.7059% (minimum 65%, Missing); colon: 68.7500% (minimum 70%, Missing); heart muscle: 64.7059% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); pancreas: 73.3333% (minimum 75%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); retina: 57.8947% (minimum 75%, Missing); skeletal muscle: 61.1111% (minimum 75%, Missing); urinary bladder: 61.1111% (minimum 70%, Missing)",-0.00294118,-0.0888889,-0.171053,0,80,unavailable,0.8,0.7,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188859,FAM78B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 64.7059% (minimum 65%, Missing); colon: 68.7500% (minimum 70%, Missing); heart muscle: 64.7059% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); pancreas: 73.3333% (minimum 75%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); retina: 57.8947% (minimum 75%, Missing); skeletal muscle: 61.1111% (minimum 75%, Missing); urinary bladder: 61.1111% (minimum 70%, Missing)",-0.00294118,-0.0888889,-0.171053,0,80,unavailable,0.8,0.7,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188859,FAM78B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 64.7059% (minimum 65%, Baseline (adaptation disabled)); colon: 68.7500% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.7059% (minimum 75%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.3333% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 68.7500% (minimum 75%, Baseline (adaptation disabled)); retina: 57.8947% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 61.1111% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 61.1111% (minimum 70%, Baseline (adaptation disabled))",-0.00294118,-0.0888889,-0.171053,0,80,unavailable,0.8,0.7,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188859,FAM78B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188877,POTEA,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188877,POTEA,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188877,POTEA,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188877,POTEA,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000188877,POTEA,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 18.1818% (minimum 99%, Missing)",0.05,0.03,-0.808182,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188909,BSX,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 18.1818% (minimum 75%, Missing)",0.35,0.3,-0.568182,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188909,BSX,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 18.1818% (minimum 75%, Missing)",0.35,0.3,-0.568182,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188909,BSX,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 18.1818% (minimum 75%, Missing)",0.35,0.3,-0.568182,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188909,BSX,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 18.1818% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.568182,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188909,BSX,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.9173% (minimum 95%, Enhanced); amygdala: 94.5232% (minimum 99%, Missing); basal ganglia: 92.1482% (minimum 99%, Missing); cerebral cortex: 83.9725% (minimum 95%, Enhanced); choroid plexus: 41.3822% (minimum 99%, Missing); duodenum: 93.5587% (minimum 95%, Enhanced); heart muscle: 79.3402% (minimum 95%, Enhanced); hippocampal formation: 92.9658% (minimum 99%, Missing); hypothalamus: 90.7797% (minimum 99%, Missing); kidney: 90.1106% (minimum 95%, Enhanced); liver: 93.7980% (minimum 95%, Enhanced); lung: 91.5730% (minimum 95%, Enhanced); midbrain: 94.5232% (minimum 99%, Missing); pancreas: 93.9782% (minimum 95%, Enhanced); pituitary gland: 97.6698% (minimum 99%, Missing); retina: 82.1849% (minimum 99%, Missing); skeletal muscle: 64.3421% (minimum 95%, Enhanced); small intestine: 93.1429% (minimum 95%, Enhanced); spinal cord: 97.1523% (minimum 99%, Missing)",0.045251,0.0293188,-0.576178,0,4,partial,207.8,17.7,25.6,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 6); heart muscle: 38.2 nTPM (vital, limit 6); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 6); esophagus: 17.7 nTPM (protected, limit 12); kidney: 16.1 nTPM (vital, limit 6); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 6); adrenal gland: 12.9 nTPM (vital, limit 6); basal ganglia: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 12); hippocampal formation: 11.1 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 6); duodenum: 10.1 nTPM (vital, limit 6); liver: 9.7 nTPM (vital, limit 6); pancreas: 9.4 nTPM (vital, limit 6); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.5 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188931,CFAP126,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 41.3822% (minimum 75%, Missing)",0.345251,0.299319,-0.336178,0,4,partial,207.8,17.7,25.6,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 6); heart muscle: 38.2 nTPM (vital, limit 6); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 6); esophagus: 17.7 nTPM (protected, limit 12); kidney: 16.1 nTPM (vital, limit 6); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 6); adrenal gland: 12.9 nTPM (vital, limit 6); basal ganglia: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 12); hippocampal formation: 11.1 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 6); duodenum: 10.1 nTPM (vital, limit 6); liver: 9.7 nTPM (vital, limit 6); pancreas: 9.4 nTPM (vital, limit 6); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.5 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188931,CFAP126,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 41.3822% (minimum 75%, Missing)",0.345251,0.299319,-0.336178,0,4,partial,207.8,17.7,25.6,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 6); heart muscle: 38.2 nTPM (vital, limit 6); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 6); esophagus: 17.7 nTPM (protected, limit 12); kidney: 16.1 nTPM (vital, limit 6); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 6); adrenal gland: 12.9 nTPM (vital, limit 6); basal ganglia: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 12); hippocampal formation: 11.1 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 6); duodenum: 10.1 nTPM (vital, limit 6); liver: 9.7 nTPM (vital, limit 6); pancreas: 9.4 nTPM (vital, limit 6); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.5 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188931,CFAP126,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 41.3822% (minimum 75%, Missing)",0.345251,0.299319,-0.336178,0,4,partial,207.8,17.7,25.6,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 6); heart muscle: 38.2 nTPM (vital, limit 6); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 6); esophagus: 17.7 nTPM (protected, limit 12); kidney: 16.1 nTPM (vital, limit 6); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 6); adrenal gland: 12.9 nTPM (vital, limit 6); basal ganglia: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 12); hippocampal formation: 11.1 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 6); duodenum: 10.1 nTPM (vital, limit 6); liver: 9.7 nTPM (vital, limit 6); pancreas: 9.4 nTPM (vital, limit 6); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.5 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188931,CFAP126,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 41.3822% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 64.3421% (minimum 75%, Baseline (adaptation disabled))",0.201422,0.192336,-0.336178,0,4,partial,207.8,17.7,25.6,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 1); heart muscle: 38.2 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); thyroid gland: 25.6 nTPM (manageable, limit 5); skin: 18.3 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 3); kidney: 16.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 1); adrenal gland: 12.9 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 3); adipose tissue: 11.1 nTPM (manageable, limit 5); hippocampal formation: 11.1 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); pancreas: 9.4 nTPM (vital, limit 1); midbrain: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); lymph node: 7.5 nTPM (protected, limit 3); stomach: 7.4 nTPM (protected, limit 3); spleen: 6.2 nTPM (manageable, limit 5); urinary bladder: 5.2 nTPM (protected, limit 3); colon: 4.8 nTPM (protected, limit 3); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000188931,CFAP126,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189023,MAGEB16,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189023,MAGEB16,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189023,MAGEB16,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189023,MAGEB16,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189023,MAGEB16,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.1132% (minimum 99%, Missing); small intestine: 98.1132% (minimum 99%, Missing)",0.05,0.0204762,-0.00886792,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189037,DUSP21,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.290476,0.231132,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189037,DUSP21,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.290476,0.231132,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189037,DUSP21,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.290476,0.231132,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189037,DUSP21,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.290476,0.231132,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189037,DUSP21,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 92.9104% (minimum 97%, Supported); pituitary gland: 74.7748% (minimum 99%, Missing)",0.05,0.03,-0.242252,0,1,partial,8.4,0.3,0.4,"pituitary gland: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189052,CGB5,admission_only,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 74.7748% (minimum 75%, Missing)",0.35,0.3,-0.00225225,0,1,partial,8.4,0.3,0.4,"pituitary gland: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189052,CGB5,selectivity_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 74.7748% (minimum 75%, Missing)",0.35,0.3,-0.00225225,0,1,partial,8.4,0.3,0.4,"pituitary gland: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189052,CGB5,grid_revised,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 74.7748% (minimum 75%, Missing)",0.35,0.3,-0.00225225,0,1,partial,8.4,0.3,0.4,"pituitary gland: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189052,CGB5,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 74.7748% (minimum 75%, Baseline (adaptation disabled))",0.33419,0.288095,-0.00225225,0,1,partial,8.4,0.3,0.4,"pituitary gland: 8.4 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189052,CGB5,current_fixed,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.05,0.03,0.00143469,0,4,partial,0.8,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189064,GAGE2A,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.241435,0,4,partial,0.8,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189064,GAGE2A,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.241435,0,4,partial,0.8,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189064,GAGE2A,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.241435,0,4,partial,0.8,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189064,GAGE2A,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.241435,0,4,partial,0.8,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189064,GAGE2A,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 35.8156% (minimum 97%, Missing); salivary gland: 54.0107% (minimum 97%, Missing); skeletal muscle: 98.0583% (minimum 99%, Missing); skin: 19.4231% (minimum 95%, Missing); small intestine: 86.3248% (minimum 99%, Missing)",-0.755769,-0.611844,-0.126752,0,80,unavailable,1.6,18.1,41.9,"skin: 41.9 nTPM (manageable, limit 5); esophagus: 18.1 nTPM (protected, limit 2); salivary gland: 8.6 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189090,FAM25G,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 35.8156% (minimum 70%, Missing); salivary gland: 54.0107% (minimum 70%, Missing); skin: 19.4231% (minimum 65%, Missing)",-0.455769,-0.341844,0.113248,0,80,unavailable,1.6,18.1,41.9,"skin: 41.9 nTPM (manageable, limit 5); esophagus: 18.1 nTPM (protected, limit 2); salivary gland: 8.6 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189090,FAM25G,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 35.8156% (minimum 70%, Missing); salivary gland: 54.0107% (minimum 70%, Missing); skin: 19.4231% (minimum 65%, Missing)",-0.455769,-0.341844,0.113248,0,80,unavailable,1.6,18.1,41.9,"skin: 41.9 nTPM (manageable, limit 5); esophagus: 18.1 nTPM (protected, limit 3); salivary gland: 8.6 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189090,FAM25G,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 35.8156% (minimum 70%, Missing); salivary gland: 54.0107% (minimum 70%, Missing); skin: 19.4231% (minimum 65%, Missing)",-0.455769,-0.341844,0.113248,0,80,unavailable,1.6,18.1,41.9,"skin: 41.9 nTPM (manageable, limit 5); esophagus: 18.1 nTPM (protected, limit 3); salivary gland: 8.6 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189090,FAM25G,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 35.8156% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 54.0107% (minimum 70%, Baseline (adaptation disabled)); skin: 19.4231% (minimum 65%, Baseline (adaptation disabled))",-0.455769,-0.341844,0.113248,0,80,unavailable,1.6,18.1,41.9,"skin: 41.9 nTPM (manageable, limit 5); esophagus: 18.1 nTPM (protected, limit 3); salivary gland: 8.6 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189090,FAM25G,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.8519% (minimum 90%, Approved); adrenal gland: 53.4351% (minimum 99%, Missing); amygdala: 56.0000% (minimum 99%, Missing); basal ganglia: 53.0303% (minimum 99%, Missing); bone marrow: 36.4583% (minimum 99%, Missing); cerebellum: 55.5556% (minimum 99%, Missing); cerebral cortex: 48.6111% (minimum 98%, Approved); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 55.5556% (minimum 97%, Missing); duodenum: 57.3770% (minimum 99%, Missing); esophagus: 53.0303% (minimum 97%, Missing); heart muscle: 58.3333% (minimum 98%, Approved); hippocampal formation: 54.2636% (minimum 99%, Missing); hypothalamus: 56.4516% (minimum 99%, Missing); kidney: 55.5556% (minimum 99%, Missing); liver: 47.9452% (minimum 99%, Missing); lung: 56.9106% (minimum 99%, Missing); lymph node: 48.6111% (minimum 97%, Missing); midbrain: 56.9106% (minimum 99%, Missing); pancreas: 54.2636% (minimum 99%, Missing); parathyroid gland: 60.3448% (minimum 97%, Missing); pituitary gland: 61.9469% (minimum 99%, Missing); rectum: 62.5000% (minimum 97%, Missing); retina: 68.6275% (minimum 99%, Missing); salivary gland: 56.0000% (minimum 97%, Missing); skeletal muscle: 62.5000% (minimum 98%, Approved); skin: 35.3535% (minimum 95%, Missing); small intestine: 51.8519% (minimum 99%, Missing); smooth muscle: 64.2202% (minimum 98%, Approved); spinal cord: 53.4351% (minimum 99%, Missing); spleen: 39.5480% (minimum 95%, Missing); stomach: 48.6111% (minimum 97%, Missing); thymus: 60.3448% (minimum 95%, Missing); thyroid gland: 60.8696% (minimum 95%, Missing); tongue: 68.6275% (minimum 97%, Missing); urinary bladder: 52.2388% (minimum 97%, Missing)",-0.596465,-0.483889,-0.625417,0,5,partial,12.2,7.4,12.8,"skin: 12.8 nTPM (manageable, limit 5); bone marrow: 12.2 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); liver: 7.6 nTPM (vital, limit 1); lymph node: 7.4 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); cerebral cortex: 7.4 nTPM (vital, limit 2); small intestine: 6.5 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 2); esophagus: 6.2 nTPM (protected, limit 2); basal ganglia: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); cerebellum: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); salivary gland: 5.5 nTPM (protected, limit 2); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 2); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189114,BLOC1S3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.8519% (minimum 60%, Approved); adrenal gland: 53.4351% (minimum 75%, Missing); amygdala: 56.0000% (minimum 75%, Missing); basal ganglia: 53.0303% (minimum 75%, Missing); bone marrow: 36.4583% (minimum 75%, Missing); cerebellum: 55.5556% (minimum 75%, Missing); cerebral cortex: 48.6111% (minimum 70%, Approved); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 57.3770% (minimum 75%, Missing); esophagus: 53.0303% (minimum 70%, Missing); heart muscle: 58.3333% (minimum 70%, Approved); hippocampal formation: 54.2636% (minimum 75%, Missing); hypothalamus: 56.4516% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 47.9452% (minimum 75%, Missing); lung: 56.9106% (minimum 75%, Missing); lymph node: 48.6111% (minimum 70%, Missing); midbrain: 56.9106% (minimum 75%, Missing); pancreas: 54.2636% (minimum 75%, Missing); parathyroid gland: 60.3448% (minimum 70%, Missing); pituitary gland: 61.9469% (minimum 75%, Missing); rectum: 62.5000% (minimum 70%, Missing); retina: 68.6275% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 70%, Approved); skin: 35.3535% (minimum 65%, Missing); small intestine: 51.8519% (minimum 75%, Missing); smooth muscle: 64.2202% (minimum 70%, Approved); spinal cord: 53.4351% (minimum 75%, Missing); spleen: 39.5480% (minimum 65%, Missing); stomach: 48.6111% (minimum 70%, Missing); thymus: 60.3448% (minimum 65%, Missing); thyroid gland: 60.8696% (minimum 65%, Missing); tongue: 68.6275% (minimum 70%, Missing); urinary bladder: 52.2388% (minimum 70%, Missing)",-0.296465,-0.213889,-0.385417,0,5,partial,12.2,7.4,12.8,"skin: 12.8 nTPM (manageable, limit 5); bone marrow: 12.2 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); liver: 7.6 nTPM (vital, limit 1); lymph node: 7.4 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); cerebral cortex: 7.4 nTPM (vital, limit 2); small intestine: 6.5 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 2); esophagus: 6.2 nTPM (protected, limit 2); basal ganglia: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); cerebellum: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); salivary gland: 5.5 nTPM (protected, limit 2); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 2); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189114,BLOC1S3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.8519% (minimum 60%, Approved); adrenal gland: 53.4351% (minimum 75%, Missing); amygdala: 56.0000% (minimum 75%, Missing); basal ganglia: 53.0303% (minimum 75%, Missing); bone marrow: 36.4583% (minimum 75%, Missing); cerebellum: 55.5556% (minimum 75%, Missing); cerebral cortex: 48.6111% (minimum 70%, Approved); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 57.3770% (minimum 75%, Missing); esophagus: 53.0303% (minimum 70%, Missing); heart muscle: 58.3333% (minimum 70%, Approved); hippocampal formation: 54.2636% (minimum 75%, Missing); hypothalamus: 56.4516% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 47.9452% (minimum 75%, Missing); lung: 56.9106% (minimum 75%, Missing); lymph node: 48.6111% (minimum 70%, Missing); midbrain: 56.9106% (minimum 75%, Missing); pancreas: 54.2636% (minimum 75%, Missing); parathyroid gland: 60.3448% (minimum 70%, Missing); pituitary gland: 61.9469% (minimum 75%, Missing); rectum: 62.5000% (minimum 70%, Missing); retina: 68.6275% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 70%, Approved); skin: 35.3535% (minimum 65%, Missing); small intestine: 51.8519% (minimum 75%, Missing); smooth muscle: 64.2202% (minimum 70%, Approved); spinal cord: 53.4351% (minimum 75%, Missing); spleen: 39.5480% (minimum 65%, Missing); stomach: 48.6111% (minimum 70%, Missing); thymus: 60.3448% (minimum 65%, Missing); thyroid gland: 60.8696% (minimum 65%, Missing); tongue: 68.6275% (minimum 70%, Missing); urinary bladder: 52.2388% (minimum 70%, Missing)",-0.296465,-0.213889,-0.385417,0,5,partial,12.2,7.4,12.8,"skin: 12.8 nTPM (manageable, limit 5); bone marrow: 12.2 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); liver: 7.6 nTPM (vital, limit 1); lymph node: 7.4 nTPM (protected, limit 3); stomach: 7.4 nTPM (protected, limit 3); cerebral cortex: 7.4 nTPM (vital, limit 2); small intestine: 6.5 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 3); esophagus: 6.2 nTPM (protected, limit 3); basal ganglia: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); cerebellum: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); salivary gland: 5.5 nTPM (protected, limit 3); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 3); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189114,BLOC1S3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.8519% (minimum 60%, Approved); adrenal gland: 53.4351% (minimum 75%, Missing); amygdala: 56.0000% (minimum 75%, Missing); basal ganglia: 53.0303% (minimum 75%, Missing); bone marrow: 36.4583% (minimum 75%, Missing); cerebellum: 55.5556% (minimum 75%, Missing); cerebral cortex: 48.6111% (minimum 70%, Approved); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 57.3770% (minimum 75%, Missing); esophagus: 53.0303% (minimum 70%, Missing); heart muscle: 58.3333% (minimum 70%, Approved); hippocampal formation: 54.2636% (minimum 75%, Missing); hypothalamus: 56.4516% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 47.9452% (minimum 75%, Missing); lung: 56.9106% (minimum 75%, Missing); lymph node: 48.6111% (minimum 70%, Missing); midbrain: 56.9106% (minimum 75%, Missing); pancreas: 54.2636% (minimum 75%, Missing); parathyroid gland: 60.3448% (minimum 70%, Missing); pituitary gland: 61.9469% (minimum 75%, Missing); rectum: 62.5000% (minimum 70%, Missing); retina: 68.6275% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 70%, Approved); skin: 35.3535% (minimum 65%, Missing); small intestine: 51.8519% (minimum 75%, Missing); smooth muscle: 64.2202% (minimum 70%, Approved); spinal cord: 53.4351% (minimum 75%, Missing); spleen: 39.5480% (minimum 65%, Missing); stomach: 48.6111% (minimum 70%, Missing); thymus: 60.3448% (minimum 65%, Missing); thyroid gland: 60.8696% (minimum 65%, Missing); tongue: 68.6275% (minimum 70%, Missing); urinary bladder: 52.2388% (minimum 70%, Missing)",-0.296465,-0.213889,-0.385417,0,5,partial,12.2,7.4,12.8,"skin: 12.8 nTPM (manageable, limit 5); bone marrow: 12.2 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); liver: 7.6 nTPM (vital, limit 1); lymph node: 7.4 nTPM (protected, limit 3); stomach: 7.4 nTPM (protected, limit 3); cerebral cortex: 7.4 nTPM (vital, limit 2); small intestine: 6.5 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 3); esophagus: 6.2 nTPM (protected, limit 3); basal ganglia: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); cerebellum: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); salivary gland: 5.5 nTPM (protected, limit 3); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 3); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189114,BLOC1S3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.8519% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 53.4351% (minimum 75%, Baseline (adaptation disabled)); amygdala: 56.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 53.0303% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 36.4583% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.5556% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.6111% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); colon: 55.5556% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.3770% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.0303% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.3333% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.2636% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 56.4516% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.5556% (minimum 75%, Baseline (adaptation disabled)); liver: 47.9452% (minimum 75%, Baseline (adaptation disabled)); lung: 56.9106% (minimum 75%, Baseline (adaptation disabled)); lymph node: 48.6111% (minimum 70%, Baseline (adaptation disabled)); midbrain: 56.9106% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.2636% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.3448% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 61.9469% (minimum 75%, Baseline (adaptation disabled)); rectum: 62.5000% (minimum 70%, Baseline (adaptation disabled)); retina: 68.6275% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); skin: 35.3535% (minimum 65%, Baseline (adaptation disabled)); small intestine: 51.8519% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.2202% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.4351% (minimum 75%, Baseline (adaptation disabled)); spleen: 39.5480% (minimum 65%, Baseline (adaptation disabled)); stomach: 48.6111% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.3448% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 60.8696% (minimum 65%, Baseline (adaptation disabled)); tongue: 68.6275% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.2388% (minimum 70%, Baseline (adaptation disabled))",-0.296465,-0.213889,-0.385417,0,5,partial,12.2,7.4,12.8,"skin: 12.8 nTPM (manageable, limit 5); bone marrow: 12.2 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); liver: 7.6 nTPM (vital, limit 1); lymph node: 7.4 nTPM (protected, limit 3); stomach: 7.4 nTPM (protected, limit 3); cerebral cortex: 7.4 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.4 nTPM (protected, limit 3); basal ganglia: 6.2 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 3); adrenal gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189114,BLOC1S3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189132,FAM47B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189132,FAM47B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189132,FAM47B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189132,FAM47B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189132,FAM47B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.5783% (minimum 95%, Missing); adrenal gland: 96.3190% (minimum 99%, Missing); amygdala: 92.6254% (minimum 99%, Missing); basal ganglia: 91.8129% (minimum 99%, Missing); cerebellum: 94.5783% (minimum 99%, Missing); cerebral cortex: 93.1751% (minimum 99%, Missing); choroid plexus: 95.4407% (minimum 99%, Missing); colon: 93.7313% (minimum 97%, Missing); heart muscle: 86.5014% (minimum 99%, Missing); hippocampal formation: 93.1751% (minimum 99%, Missing); hypothalamus: 92.8994% (minimum 99%, Missing); kidney: 94.2943% (minimum 99%, Missing); liver: 97.5155% (minimum 99%, Missing); lung: 97.8193% (minimum 99%, Missing); midbrain: 89.7143% (minimum 99%, Missing); pancreas: 95.4407% (minimum 99%, Missing); pituitary gland: 94.0120% (minimum 99%, Missing); retina: 72.0183% (minimum 99%, Missing); salivary gland: 95.1515% (minimum 97%, Missing); skeletal muscle: 85.3261% (minimum 99%, Missing); small intestine: 97.8193% (minimum 99%, Missing); smooth muscle: 95.7317% (minimum 99%, Missing); spinal cord: 88.9518% (minimum 99%, Missing); stomach: 96.6154% (minimum 97%, Missing); tongue: 89.2045% (minimum 97%, Missing); urinary bladder: 94.2943% (minimum 97%, Missing)",-0.00421687,-0.0779545,-0.269817,0,80,unavailable,12.2,3.8,1.8,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189134,NKAPL,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.0183% (minimum 75%, Missing)",0.295783,0.192045,-0.0298165,0,80,unavailable,12.2,3.8,1.8,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189134,NKAPL,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.0183% (minimum 75%, Missing)",0.295783,0.192045,-0.0298165,0,80,unavailable,12.2,3.8,1.8,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189134,NKAPL,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.0183% (minimum 75%, Missing)",0.295783,0.192045,-0.0298165,0,80,unavailable,12.2,3.8,1.8,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189134,NKAPL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.0183% (minimum 75%, Baseline (adaptation disabled))",0.295783,0.192045,-0.0298165,0,80,unavailable,12.2,3.8,1.8,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189134,NKAPL,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189139,FSCB,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189139,FSCB,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189139,FSCB,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189139,FSCB,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189139,FSCB,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.1163% (minimum 95%, Missing); adrenal gland: 71.7949% (minimum 99%, Missing); amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 59.5745% (minimum 99%, Missing); cerebellum: 84.8485% (minimum 99%, Missing); cerebral cortex: 68.2927% (minimum 99%, Missing); choroid plexus: 84.8485% (minimum 99%, Missing); colon: 75.6757% (minimum 97%, Missing); duodenum: 68.2927% (minimum 99%, Missing); esophagus: 80.0000% (minimum 97%, Missing); heart muscle: 75.6757% (minimum 99%, Missing); hippocampal formation: 90.3226% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); kidney: 70.0000% (minimum 99%, Missing); liver: 82.3529% (minimum 99%, Missing); lung: 68.2927% (minimum 99%, Missing); lymph node: 71.7949% (minimum 97%, Missing); midbrain: 87.5000% (minimum 99%, Missing); pancreas: 70.0000% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 77.7778% (minimum 99%, Missing); rectum: 71.7949% (minimum 97%, Missing); retina: 52.8302% (minimum 99%, Missing); salivary gland: 77.7778% (minimum 97%, Missing); skeletal muscle: 75.6757% (minimum 99%, Missing); skin: 57.1429% (minimum 95%, Missing); small intestine: 73.6842% (minimum 99%, Missing); smooth muscle: 77.7778% (minimum 99%, Missing); spinal cord: 82.3529% (minimum 99%, Missing); spleen: 63.6364% (minimum 95%, Missing); stomach: 59.5745% (minimum 97%, Missing); thymus: 71.7949% (minimum 95%, Missing); thyroid gland: 53.8462% (minimum 95%, Missing); tongue: 84.8485% (minimum 97%, Missing); urinary bladder: 80.0000% (minimum 97%, Missing)",-0.411538,-0.374255,-0.461698,0,3,partial,2.5,1.9,2.4,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189144,ZNF573,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.7949% (minimum 75%, Missing); bone marrow: 59.5745% (minimum 75%, Missing); cerebral cortex: 68.2927% (minimum 75%, Missing); duodenum: 68.2927% (minimum 75%, Missing); kidney: 70.0000% (minimum 75%, Missing); lung: 68.2927% (minimum 75%, Missing); pancreas: 70.0000% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); retina: 52.8302% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); small intestine: 73.6842% (minimum 75%, Missing); spleen: 63.6364% (minimum 65%, Missing); stomach: 59.5745% (minimum 70%, Missing); thyroid gland: 53.8462% (minimum 65%, Missing)",-0.111538,-0.104255,-0.221698,0,3,partial,2.5,1.9,2.4,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189144,ZNF573,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.7949% (minimum 75%, Missing); bone marrow: 59.5745% (minimum 75%, Missing); cerebral cortex: 68.2927% (minimum 75%, Missing); duodenum: 68.2927% (minimum 75%, Missing); kidney: 70.0000% (minimum 75%, Missing); lung: 68.2927% (minimum 75%, Missing); pancreas: 70.0000% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); retina: 52.8302% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); small intestine: 73.6842% (minimum 75%, Missing); spleen: 63.6364% (minimum 65%, Missing); stomach: 59.5745% (minimum 70%, Missing); thyroid gland: 53.8462% (minimum 65%, Missing)",-0.111538,-0.104255,-0.221698,0,3,partial,2.5,1.9,2.4,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189144,ZNF573,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.7949% (minimum 75%, Missing); bone marrow: 59.5745% (minimum 75%, Missing); cerebral cortex: 68.2927% (minimum 75%, Missing); duodenum: 68.2927% (minimum 75%, Missing); kidney: 70.0000% (minimum 75%, Missing); lung: 68.2927% (minimum 75%, Missing); pancreas: 70.0000% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); retina: 52.8302% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); small intestine: 73.6842% (minimum 75%, Missing); spleen: 63.6364% (minimum 65%, Missing); stomach: 59.5745% (minimum 70%, Missing); thyroid gland: 53.8462% (minimum 65%, Missing)",-0.111538,-0.104255,-0.221698,0,3,partial,2.5,1.9,2.4,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189144,ZNF573,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.7949% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 59.5745% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.2927% (minimum 75%, Baseline (adaptation disabled)); duodenum: 68.2927% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 68.2927% (minimum 75%, Baseline (adaptation disabled)); pancreas: 70.0000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 52.8302% (minimum 75%, Baseline (adaptation disabled)); skin: 57.1429% (minimum 65%, Baseline (adaptation disabled)); small intestine: 73.6842% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.6364% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.5745% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.8462% (minimum 65%, Baseline (adaptation disabled))",-0.111538,-0.104255,-0.221698,0,3,partial,2.5,1.9,2.4,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189144,ZNF573,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 95%, Missing); adrenal gland: 61.5385% (minimum 99%, Missing); amygdala: 69.5652% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 58.1818% (minimum 99%, Missing); cerebellum: 61.5385% (minimum 99%, Missing); cerebral cortex: 65.3061% (minimum 99%, Missing); choroid plexus: 76.1905% (minimum 99%, Missing); colon: 56.1404% (minimum 97%, Missing); duodenum: 82.0513% (minimum 99%, Missing); esophagus: 69.5652% (minimum 97%, Missing); heart muscle: 59.2593% (minimum 99%, Missing); hippocampal formation: 68.0851% (minimum 99%, Missing); hypothalamus: 65.3061% (minimum 99%, Missing); kidney: 60.3774% (minimum 99%, Missing); liver: 65.3061% (minimum 99%, Missing); lung: 69.5652% (minimum 99%, Missing); lymph node: 61.5385% (minimum 97%, Missing); midbrain: 68.0851% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 55.1724% (minimum 97%, Missing); pituitary gland: 59.2593% (minimum 99%, Missing); rectum: 69.5652% (minimum 97%, Missing); retina: 50.7937% (minimum 99%, Missing); salivary gland: 64.0000% (minimum 97%, Missing); skeletal muscle: 59.2593% (minimum 99%, Missing); skin: 65.3061% (minimum 95%, Missing); small intestine: 65.3061% (minimum 99%, Missing); smooth muscle: 64.0000% (minimum 99%, Missing); spinal cord: 68.0851% (minimum 99%, Missing); spleen: 62.7451% (minimum 95%, Missing); stomach: 65.3061% (minimum 97%, Missing); thymus: 57.1429% (minimum 95%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); tongue: 52.4590% (minimum 97%, Missing); urinary bladder: 58.1818% (minimum 97%, Missing)",-0.378571,-0.44541,-0.482063,0,80,unavailable,3.1,2.9,2.4,"retina: 3.1 nTPM (vital, limit 1); tongue: 2.9 nTPM (protected, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); urinary bladder: 2.3 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189164,ZNF527,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 65%, Missing); adrenal gland: 61.5385% (minimum 75%, Missing); amygdala: 69.5652% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); bone marrow: 58.1818% (minimum 75%, Missing); cerebellum: 61.5385% (minimum 75%, Missing); cerebral cortex: 65.3061% (minimum 75%, Missing); colon: 56.1404% (minimum 70%, Missing); esophagus: 69.5652% (minimum 70%, Missing); heart muscle: 59.2593% (minimum 75%, Missing); hippocampal formation: 68.0851% (minimum 75%, Missing); hypothalamus: 65.3061% (minimum 75%, Missing); kidney: 60.3774% (minimum 75%, Missing); liver: 65.3061% (minimum 75%, Missing); lung: 69.5652% (minimum 75%, Missing); lymph node: 61.5385% (minimum 70%, Missing); midbrain: 68.0851% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 55.1724% (minimum 70%, Missing); pituitary gland: 59.2593% (minimum 75%, Missing); rectum: 69.5652% (minimum 70%, Missing); retina: 50.7937% (minimum 75%, Missing); salivary gland: 64.0000% (minimum 70%, Missing); skeletal muscle: 59.2593% (minimum 75%, Missing); small intestine: 65.3061% (minimum 75%, Missing); smooth muscle: 64.0000% (minimum 75%, Missing); spinal cord: 68.0851% (minimum 75%, Missing); spleen: 62.7451% (minimum 65%, Missing); stomach: 65.3061% (minimum 70%, Missing); thymus: 57.1429% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); tongue: 52.4590% (minimum 70%, Missing); urinary bladder: 58.1818% (minimum 70%, Missing)",-0.0785714,-0.17541,-0.242063,0,80,unavailable,3.1,2.9,2.4,"retina: 3.1 nTPM (vital, limit 1); tongue: 2.9 nTPM (protected, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); urinary bladder: 2.3 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189164,ZNF527,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 65%, Missing); adrenal gland: 61.5385% (minimum 75%, Missing); amygdala: 69.5652% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); bone marrow: 58.1818% (minimum 75%, Missing); cerebellum: 61.5385% (minimum 75%, Missing); cerebral cortex: 65.3061% (minimum 75%, Missing); colon: 56.1404% (minimum 70%, Missing); esophagus: 69.5652% (minimum 70%, Missing); heart muscle: 59.2593% (minimum 75%, Missing); hippocampal formation: 68.0851% (minimum 75%, Missing); hypothalamus: 65.3061% (minimum 75%, Missing); kidney: 60.3774% (minimum 75%, Missing); liver: 65.3061% (minimum 75%, Missing); lung: 69.5652% (minimum 75%, Missing); lymph node: 61.5385% (minimum 70%, Missing); midbrain: 68.0851% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 55.1724% (minimum 70%, Missing); pituitary gland: 59.2593% (minimum 75%, Missing); rectum: 69.5652% (minimum 70%, Missing); retina: 50.7937% (minimum 75%, Missing); salivary gland: 64.0000% (minimum 70%, Missing); skeletal muscle: 59.2593% (minimum 75%, Missing); small intestine: 65.3061% (minimum 75%, Missing); smooth muscle: 64.0000% (minimum 75%, Missing); spinal cord: 68.0851% (minimum 75%, Missing); spleen: 62.7451% (minimum 65%, Missing); stomach: 65.3061% (minimum 70%, Missing); thymus: 57.1429% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); tongue: 52.4590% (minimum 70%, Missing); urinary bladder: 58.1818% (minimum 70%, Missing)",-0.0785714,-0.17541,-0.242063,0,80,unavailable,3.1,2.9,2.4,"retina: 3.1 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189164,ZNF527,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 65%, Missing); adrenal gland: 61.5385% (minimum 75%, Missing); amygdala: 69.5652% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); bone marrow: 58.1818% (minimum 75%, Missing); cerebellum: 61.5385% (minimum 75%, Missing); cerebral cortex: 65.3061% (minimum 75%, Missing); colon: 56.1404% (minimum 70%, Missing); esophagus: 69.5652% (minimum 70%, Missing); heart muscle: 59.2593% (minimum 75%, Missing); hippocampal formation: 68.0851% (minimum 75%, Missing); hypothalamus: 65.3061% (minimum 75%, Missing); kidney: 60.3774% (minimum 75%, Missing); liver: 65.3061% (minimum 75%, Missing); lung: 69.5652% (minimum 75%, Missing); lymph node: 61.5385% (minimum 70%, Missing); midbrain: 68.0851% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 55.1724% (minimum 70%, Missing); pituitary gland: 59.2593% (minimum 75%, Missing); rectum: 69.5652% (minimum 70%, Missing); retina: 50.7937% (minimum 75%, Missing); salivary gland: 64.0000% (minimum 70%, Missing); skeletal muscle: 59.2593% (minimum 75%, Missing); small intestine: 65.3061% (minimum 75%, Missing); smooth muscle: 64.0000% (minimum 75%, Missing); spinal cord: 68.0851% (minimum 75%, Missing); spleen: 62.7451% (minimum 65%, Missing); stomach: 65.3061% (minimum 70%, Missing); thymus: 57.1429% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); tongue: 52.4590% (minimum 70%, Missing); urinary bladder: 58.1818% (minimum 70%, Missing)",-0.0785714,-0.17541,-0.242063,0,80,unavailable,3.1,2.9,2.4,"retina: 3.1 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189164,ZNF527,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 61.5385% (minimum 75%, Baseline (adaptation disabled)); amygdala: 69.5652% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 58.1818% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.5385% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.3061% (minimum 75%, Baseline (adaptation disabled)); colon: 56.1404% (minimum 70%, Baseline (adaptation disabled)); esophagus: 69.5652% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.2593% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.0851% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.3061% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.3774% (minimum 75%, Baseline (adaptation disabled)); liver: 65.3061% (minimum 75%, Baseline (adaptation disabled)); lung: 69.5652% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.5385% (minimum 70%, Baseline (adaptation disabled)); midbrain: 68.0851% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.1724% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 59.2593% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.5652% (minimum 70%, Baseline (adaptation disabled)); retina: 50.7937% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 59.2593% (minimum 75%, Baseline (adaptation disabled)); small intestine: 65.3061% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.0851% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.7451% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.3061% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.1429% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 65%, Baseline (adaptation disabled)); tongue: 52.4590% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.1818% (minimum 70%, Baseline (adaptation disabled))",-0.0785714,-0.17541,-0.242063,0,80,unavailable,3.1,2.9,2.4,"retina: 3.1 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189164,ZNF527,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 87.5000% (minimum 99%, Missing); lymph node: 87.5000% (minimum 97%, Missing)",0.05,-0.095,-0.115,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189167,ZAR1L,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.175,0.125,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189167,ZAR1L,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.175,0.125,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189167,ZAR1L,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.175,0.125,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189167,ZAR1L,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.175,0.125,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189167,ZAR1L,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,9.5,"skin: 9.5 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000189169,KRTAP10-12,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,9.5,"skin: 9.5 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000189169,KRTAP10-12,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,9.5,"skin: 9.5 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000189169,KRTAP10-12,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,9.5,"skin: 9.5 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000189169,KRTAP10-12,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,9.5,"skin: 9.5 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000189169,KRTAP10-12,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189186,DCAF8L2,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189186,DCAF8L2,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189186,DCAF8L2,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189186,DCAF8L2,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189186,DCAF8L2,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.3471% (minimum 99%, Missing); small intestine: 98.9605% (minimum 99%, Missing)",0.05,0.03,-0.00652893,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189252,SPANXN3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.233471,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189252,SPANXN3,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.233471,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189252,SPANXN3,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.233471,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189252,SPANXN3,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.233471,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189252,SPANXN3,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9892% (minimum 99%, Missing); bone marrow: 92.4180% (minimum 99%, Missing); cerebellum: 96.5739% (minimum 99%, Missing); cerebral cortex: 98.6871% (minimum 99%, Missing); choroid plexus: 96.3675% (minimum 99%, Missing); duodenum: 97.8308% (minimum 99%, Missing); kidney: 94.7479% (minimum 99%, Missing); liver: 98.4716% (minimum 99%, Missing); lung: 97.4082% (minimum 99%, Missing); lymph node: 95.1477% (minimum 97%, Missing); pancreas: 95.1477% (minimum 99%, Missing); parathyroid gland: 83.5185% (minimum 97%, Missing); pituitary gland: 96.9892% (minimum 99%, Missing); retina: 92.2290% (minimum 99%, Missing); salivary gland: 96.7811% (minimum 97%, Missing); skin: 93.3747% (minimum 95%, Missing); small intestine: 97.8308% (minimum 99%, Missing); smooth muscle: 96.9892% (minimum 99%, Missing)",-0.0162526,-0.134815,-0.0677096,0,80,unavailable,3.8,8.9,3.2,"parathyroid gland: 8.9 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189269,DRICH1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.283747,0.135185,0.17229,0,80,unavailable,3.8,8.9,3.2,"parathyroid gland: 8.9 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189269,DRICH1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.283747,0.135185,0.17229,0,80,unavailable,3.8,8.9,3.2,"parathyroid gland: 8.9 nTPM (protected, limit 3); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189269,DRICH1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.283747,0.135185,0.17229,0,80,unavailable,3.8,8.9,3.2,"parathyroid gland: 8.9 nTPM (protected, limit 3); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189269,DRICH1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.283747,0.135185,0.17229,0,80,unavailable,3.8,8.9,3.2,"parathyroid gland: 8.9 nTPM (protected, limit 3); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189269,DRICH1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.8333% (minimum 90%, Approved); adrenal gland: 67.1053% (minimum 99%, Missing); amygdala: 80.9524% (minimum 99%, Missing); basal ganglia: 79.6875% (minimum 99%, Missing); bone marrow: 82.2581% (minimum 99%, Missing); cerebellum: 77.2727% (minimum 99%, Missing); cerebral cortex: 69.8630% (minimum 99%, Missing); choroid plexus: 68.0000% (minimum 99%, Missing); colon: 60.7143% (minimum 97%, Missing); duodenum: 70.8333% (minimum 99%, Missing); esophagus: 68.9189% (minimum 97%, Missing); heart muscle: 68.9189% (minimum 99%, Missing); hippocampal formation: 79.6875% (minimum 99%, Missing); hypothalamus: 79.6875% (minimum 99%, Missing); kidney: 61.4458% (minimum 99%, Missing); liver: 65.3846% (minimum 99%, Missing); lung: 62.9630% (minimum 99%, Missing); lymph node: 63.7500% (minimum 97%, Missing); midbrain: 78.4615% (minimum 99%, Missing); pancreas: 69.8630% (minimum 99%, Missing); parathyroid gland: 52.5773% (minimum 97%, Missing); pituitary gland: 66.2338% (minimum 99%, Missing); rectum: 57.9545% (minimum 97%, Missing); retina: 57.9545% (minimum 99%, Missing); salivary gland: 68.9189% (minimum 95%, Approved); skeletal muscle: 68.0000% (minimum 99%, Missing); skin: 57.9545% (minimum 95%, Missing); small intestine: 68.9189% (minimum 99%, Missing); smooth muscle: 53.1250% (minimum 99%, Missing); spinal cord: 76.1194% (minimum 99%, Missing); spleen: 60.7143% (minimum 95%, Missing); stomach: 56.0440% (minimum 97%, Missing); thymus: 54.8387% (minimum 95%, Missing); thyroid gland: 54.8387% (minimum 95%, Missing); tongue: 68.0000% (minimum 97%, Missing); urinary bladder: 65.3846% (minimum 97%, Missing)",-0.401613,-0.444227,-0.45875,0,3,partial,4.5,4.6,4.2,"parathyroid gland: 4.6 nTPM (protected, limit 2); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); retina: 3.7 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); liver: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189298,ZKSCAN3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.1053% (minimum 75%, Missing); cerebral cortex: 69.8630% (minimum 75%, Missing); choroid plexus: 68.0000% (minimum 75%, Missing); colon: 60.7143% (minimum 70%, Missing); duodenum: 70.8333% (minimum 75%, Missing); esophagus: 68.9189% (minimum 70%, Missing); heart muscle: 68.9189% (minimum 75%, Missing); kidney: 61.4458% (minimum 75%, Missing); liver: 65.3846% (minimum 75%, Missing); lung: 62.9630% (minimum 75%, Missing); lymph node: 63.7500% (minimum 70%, Missing); pancreas: 69.8630% (minimum 75%, Missing); parathyroid gland: 52.5773% (minimum 70%, Missing); pituitary gland: 66.2338% (minimum 75%, Missing); rectum: 57.9545% (minimum 70%, Missing); retina: 57.9545% (minimum 75%, Missing); skeletal muscle: 68.0000% (minimum 75%, Missing); skin: 57.9545% (minimum 65%, Missing); small intestine: 68.9189% (minimum 75%, Missing); smooth muscle: 53.1250% (minimum 75%, Missing); spleen: 60.7143% (minimum 65%, Missing); stomach: 56.0440% (minimum 70%, Missing); thymus: 54.8387% (minimum 65%, Missing); thyroid gland: 54.8387% (minimum 65%, Missing); tongue: 68.0000% (minimum 70%, Missing); urinary bladder: 65.3846% (minimum 70%, Missing)",-0.101613,-0.174227,-0.21875,0,3,partial,4.5,4.6,4.2,"parathyroid gland: 4.6 nTPM (protected, limit 2); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); retina: 3.7 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); liver: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189298,ZKSCAN3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.1053% (minimum 75%, Missing); cerebral cortex: 69.8630% (minimum 75%, Missing); choroid plexus: 68.0000% (minimum 75%, Missing); colon: 60.7143% (minimum 70%, Missing); duodenum: 70.8333% (minimum 75%, Missing); esophagus: 68.9189% (minimum 70%, Missing); heart muscle: 68.9189% (minimum 75%, Missing); kidney: 61.4458% (minimum 75%, Missing); liver: 65.3846% (minimum 75%, Missing); lung: 62.9630% (minimum 75%, Missing); lymph node: 63.7500% (minimum 70%, Missing); pancreas: 69.8630% (minimum 75%, Missing); parathyroid gland: 52.5773% (minimum 70%, Missing); pituitary gland: 66.2338% (minimum 75%, Missing); rectum: 57.9545% (minimum 70%, Missing); retina: 57.9545% (minimum 75%, Missing); skeletal muscle: 68.0000% (minimum 75%, Missing); skin: 57.9545% (minimum 65%, Missing); small intestine: 68.9189% (minimum 75%, Missing); smooth muscle: 53.1250% (minimum 75%, Missing); spleen: 60.7143% (minimum 65%, Missing); stomach: 56.0440% (minimum 70%, Missing); thymus: 54.8387% (minimum 65%, Missing); thyroid gland: 54.8387% (minimum 65%, Missing); tongue: 68.0000% (minimum 70%, Missing); urinary bladder: 65.3846% (minimum 70%, Missing)",-0.101613,-0.174227,-0.21875,0,3,partial,4.5,4.6,4.2,"parathyroid gland: 4.6 nTPM (protected, limit 3); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); retina: 3.7 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189298,ZKSCAN3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.1053% (minimum 75%, Missing); cerebral cortex: 69.8630% (minimum 75%, Missing); choroid plexus: 68.0000% (minimum 75%, Missing); colon: 60.7143% (minimum 70%, Missing); duodenum: 70.8333% (minimum 75%, Missing); esophagus: 68.9189% (minimum 70%, Missing); heart muscle: 68.9189% (minimum 75%, Missing); kidney: 61.4458% (minimum 75%, Missing); liver: 65.3846% (minimum 75%, Missing); lung: 62.9630% (minimum 75%, Missing); lymph node: 63.7500% (minimum 70%, Missing); pancreas: 69.8630% (minimum 75%, Missing); parathyroid gland: 52.5773% (minimum 70%, Missing); pituitary gland: 66.2338% (minimum 75%, Missing); rectum: 57.9545% (minimum 70%, Missing); retina: 57.9545% (minimum 75%, Missing); skeletal muscle: 68.0000% (minimum 75%, Missing); skin: 57.9545% (minimum 65%, Missing); small intestine: 68.9189% (minimum 75%, Missing); smooth muscle: 53.1250% (minimum 75%, Missing); spleen: 60.7143% (minimum 65%, Missing); stomach: 56.0440% (minimum 70%, Missing); thymus: 54.8387% (minimum 65%, Missing); thyroid gland: 54.8387% (minimum 65%, Missing); tongue: 68.0000% (minimum 70%, Missing); urinary bladder: 65.3846% (minimum 70%, Missing)",-0.101613,-0.174227,-0.21875,0,3,partial,4.5,4.6,4.2,"parathyroid gland: 4.6 nTPM (protected, limit 3); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); retina: 3.7 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189298,ZKSCAN3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.1053% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 69.8630% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 60.7143% (minimum 70%, Baseline (adaptation disabled)); duodenum: 70.8333% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.9189% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.9189% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.4458% (minimum 75%, Baseline (adaptation disabled)); liver: 65.3846% (minimum 75%, Baseline (adaptation disabled)); lung: 62.9630% (minimum 75%, Baseline (adaptation disabled)); lymph node: 63.7500% (minimum 70%, Baseline (adaptation disabled)); pancreas: 69.8630% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.5773% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 66.2338% (minimum 75%, Baseline (adaptation disabled)); rectum: 57.9545% (minimum 70%, Baseline (adaptation disabled)); retina: 57.9545% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.9189% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 68.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 57.9545% (minimum 65%, Baseline (adaptation disabled)); small intestine: 68.9189% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.1250% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.7143% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.0440% (minimum 70%, Baseline (adaptation disabled)); thymus: 54.8387% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.8387% (minimum 65%, Baseline (adaptation disabled)); tongue: 68.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.3846% (minimum 70%, Baseline (adaptation disabled))",-0.101613,-0.174227,-0.21875,0,3,partial,4.5,4.6,4.2,"parathyroid gland: 4.6 nTPM (protected, limit 3); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); retina: 3.7 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189298,ZKSCAN3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189299,FOXR2,admission_only,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189299,FOXR2,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189299,FOXR2,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189299,FOXR2,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189299,FOXR2,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189326,SPANXN4,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189326,SPANXN4,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189326,SPANXN4,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189326,SPANXN4,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189326,SPANXN4,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189357,SPATA31D4,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189357,SPATA31D4,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189357,SPATA31D4,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189357,SPATA31D4,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189357,SPATA31D4,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.4419% (minimum 95%, Missing); adrenal gland: 64.4444% (minimum 99%, Missing); amygdala: 76.3158% (minimum 99%, Missing); basal ganglia: 76.3158% (minimum 99%, Missing); bone marrow: 60.4167% (minimum 99%, Missing); cerebellum: 55.7692% (minimum 99%, Missing); cerebral cortex: 70.7317% (minimum 99%, Missing); choroid plexus: 78.3784% (minimum 99%, Missing); colon: 69.0476% (minimum 97%, Missing); duodenum: 76.3158% (minimum 99%, Missing); esophagus: 65.9091% (minimum 97%, Missing); heart muscle: 76.3158% (minimum 99%, Missing); hippocampal formation: 72.5000% (minimum 99%, Missing); hypothalamus: 76.3158% (minimum 99%, Missing); kidney: 69.0476% (minimum 99%, Missing); liver: 63.0435% (minimum 99%, Missing); lung: 64.4444% (minimum 99%, Missing); lymph node: 44.6154% (minimum 97%, Missing); midbrain: 70.7317% (minimum 99%, Missing); pancreas: 72.5000% (minimum 99%, Missing); parathyroid gland: 74.3590% (minimum 97%, Missing); pituitary gland: 70.7317% (minimum 99%, Missing); rectum: 76.3158% (minimum 97%, Missing); retina: 70.7317% (minimum 99%, Missing); salivary gland: 59.1837% (minimum 97%, Missing); skeletal muscle: 85.2941% (minimum 99%, Missing); skin: 59.1837% (minimum 95%, Missing); small intestine: 64.4444% (minimum 99%, Missing); smooth muscle: 72.5000% (minimum 99%, Missing); spinal cord: 72.5000% (minimum 99%, Missing); spleen: 55.7692% (minimum 95%, Missing); stomach: 61.7021% (minimum 97%, Missing); thymus: 39.1892% (minimum 95%, Missing); thyroid gland: 60.4167% (minimum 95%, Missing); tongue: 82.8571% (minimum 97%, Missing); urinary bladder: 70.7317% (minimum 97%, Missing)",-0.558108,-0.523846,-0.432308,0,80,unavailable,2.3,3.6,4.5,"lymph node: 3.6 nTPM (protected, limit 2); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189362,NEMP2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 64.4444% (minimum 75%, Missing); bone marrow: 60.4167% (minimum 75%, Missing); cerebellum: 55.7692% (minimum 75%, Missing); cerebral cortex: 70.7317% (minimum 75%, Missing); colon: 69.0476% (minimum 70%, Missing); esophagus: 65.9091% (minimum 70%, Missing); hippocampal formation: 72.5000% (minimum 75%, Missing); kidney: 69.0476% (minimum 75%, Missing); liver: 63.0435% (minimum 75%, Missing); lung: 64.4444% (minimum 75%, Missing); lymph node: 44.6154% (minimum 70%, Missing); midbrain: 70.7317% (minimum 75%, Missing); pancreas: 72.5000% (minimum 75%, Missing); pituitary gland: 70.7317% (minimum 75%, Missing); retina: 70.7317% (minimum 75%, Missing); salivary gland: 59.1837% (minimum 70%, Missing); skin: 59.1837% (minimum 65%, Missing); small intestine: 64.4444% (minimum 75%, Missing); smooth muscle: 72.5000% (minimum 75%, Missing); spinal cord: 72.5000% (minimum 75%, Missing); spleen: 55.7692% (minimum 65%, Missing); stomach: 61.7021% (minimum 70%, Missing); thymus: 39.1892% (minimum 65%, Missing); thyroid gland: 60.4167% (minimum 65%, Missing)",-0.258108,-0.253846,-0.192308,0,80,unavailable,2.3,3.6,4.5,"lymph node: 3.6 nTPM (protected, limit 2); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189362,NEMP2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 64.4444% (minimum 75%, Missing); bone marrow: 60.4167% (minimum 75%, Missing); cerebellum: 55.7692% (minimum 75%, Missing); cerebral cortex: 70.7317% (minimum 75%, Missing); colon: 69.0476% (minimum 70%, Missing); esophagus: 65.9091% (minimum 70%, Missing); hippocampal formation: 72.5000% (minimum 75%, Missing); kidney: 69.0476% (minimum 75%, Missing); liver: 63.0435% (minimum 75%, Missing); lung: 64.4444% (minimum 75%, Missing); lymph node: 44.6154% (minimum 70%, Missing); midbrain: 70.7317% (minimum 75%, Missing); pancreas: 72.5000% (minimum 75%, Missing); pituitary gland: 70.7317% (minimum 75%, Missing); retina: 70.7317% (minimum 75%, Missing); salivary gland: 59.1837% (minimum 70%, Missing); skin: 59.1837% (minimum 65%, Missing); small intestine: 64.4444% (minimum 75%, Missing); smooth muscle: 72.5000% (minimum 75%, Missing); spinal cord: 72.5000% (minimum 75%, Missing); spleen: 55.7692% (minimum 65%, Missing); stomach: 61.7021% (minimum 70%, Missing); thymus: 39.1892% (minimum 65%, Missing); thyroid gland: 60.4167% (minimum 65%, Missing)",-0.258108,-0.253846,-0.192308,0,80,unavailable,2.3,3.6,4.5,"lymph node: 3.6 nTPM (protected, limit 3); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189362,NEMP2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 64.4444% (minimum 75%, Missing); bone marrow: 60.4167% (minimum 75%, Missing); cerebellum: 55.7692% (minimum 75%, Missing); cerebral cortex: 70.7317% (minimum 75%, Missing); colon: 69.0476% (minimum 70%, Missing); esophagus: 65.9091% (minimum 70%, Missing); hippocampal formation: 72.5000% (minimum 75%, Missing); kidney: 69.0476% (minimum 75%, Missing); liver: 63.0435% (minimum 75%, Missing); lung: 64.4444% (minimum 75%, Missing); lymph node: 44.6154% (minimum 70%, Missing); midbrain: 70.7317% (minimum 75%, Missing); pancreas: 72.5000% (minimum 75%, Missing); pituitary gland: 70.7317% (minimum 75%, Missing); retina: 70.7317% (minimum 75%, Missing); salivary gland: 59.1837% (minimum 70%, Missing); skin: 59.1837% (minimum 65%, Missing); small intestine: 64.4444% (minimum 75%, Missing); smooth muscle: 72.5000% (minimum 75%, Missing); spinal cord: 72.5000% (minimum 75%, Missing); spleen: 55.7692% (minimum 65%, Missing); stomach: 61.7021% (minimum 70%, Missing); thymus: 39.1892% (minimum 65%, Missing); thyroid gland: 60.4167% (minimum 65%, Missing)",-0.258108,-0.253846,-0.192308,0,80,unavailable,2.3,3.6,4.5,"lymph node: 3.6 nTPM (protected, limit 3); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189362,NEMP2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 64.4444% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 60.4167% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.7692% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.7317% (minimum 75%, Baseline (adaptation disabled)); colon: 69.0476% (minimum 70%, Baseline (adaptation disabled)); esophagus: 65.9091% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 72.5000% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.0476% (minimum 75%, Baseline (adaptation disabled)); liver: 63.0435% (minimum 75%, Baseline (adaptation disabled)); lung: 64.4444% (minimum 75%, Baseline (adaptation disabled)); lymph node: 44.6154% (minimum 70%, Baseline (adaptation disabled)); midbrain: 70.7317% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.5000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 70.7317% (minimum 75%, Baseline (adaptation disabled)); retina: 70.7317% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.1837% (minimum 70%, Baseline (adaptation disabled)); skin: 59.1837% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.4444% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.5000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 72.5000% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.7692% (minimum 65%, Baseline (adaptation disabled)); stomach: 61.7021% (minimum 70%, Baseline (adaptation disabled)); thymus: 39.1892% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 60.4167% (minimum 65%, Baseline (adaptation disabled))",-0.258108,-0.253846,-0.192308,0,80,unavailable,2.3,3.6,4.5,"lymph node: 3.6 nTPM (protected, limit 3); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189362,NEMP2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0407834,0.0253704,0.00078341,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189375,TBC1D28,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340783,0.29537,0.240783,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189375,TBC1D28,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340783,0.29537,0.240783,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189375,TBC1D28,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340783,0.29537,0.240783,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189375,TBC1D28,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.340783,0.29537,0.240783,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189375,TBC1D28,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 86.7925% (minimum 95%, Enhanced); choroid plexus: 95.8333% (minimum 99%, Missing); retina: 97.8723% (minimum 99%, Missing)",0.05,0.03,-0.0820755,0,6,partial,0.7,0.1,0.3,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189401,OTUD6A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.208333,0,6,partial,0.7,0.1,0.3,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189401,OTUD6A,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.208333,0,6,partial,0.7,0.1,0.3,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189401,OTUD6A,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.208333,0,6,partial,0.7,0.1,0.3,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189401,OTUD6A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.288776,0.278723,0.117925,0,6,partial,0.7,0.1,0.3,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000189401,OTUD6A,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.0958% (minimum 95%, Missing); adrenal gland: 98.1221% (minimum 99%, Missing); amygdala: 96.3134% (minimum 99%, Missing); basal ganglia: 95.0000% (minimum 99%, Missing); bone marrow: 94.7846% (minimum 99%, Missing); cerebellum: 93.9326% (minimum 99%, Missing); cerebral cortex: 93.7220% (minimum 99%, Missing); choroid plexus: 98.8180% (minimum 99%, Missing); colon: 96.9838% (minimum 97%, Missing); duodenum: 96.3134% (minimum 99%, Missing); heart muscle: 94.5701% (minimum 99%, Missing); hippocampal formation: 96.3134% (minimum 99%, Missing); hypothalamus: 96.3134% (minimum 99%, Missing); kidney: 90.8696% (minimum 99%, Missing); liver: 97.4359% (minimum 99%, Missing); lung: 95.2164% (minimum 99%, Missing); lymph node: 94.3567% (minimum 97%, Missing); midbrain: 95.6522% (minimum 99%, Missing); pancreas: 86.7220% (minimum 99%, Missing); pituitary gland: 95.6522% (minimum 99%, Missing); retina: 96.7593% (minimum 99%, Missing); salivary gland: 90.6725% (minimum 97%, Missing); skeletal muscle: 97.2093% (minimum 99%, Missing); skin: 93.9326% (minimum 95%, Missing); small intestine: 94.7846% (minimum 99%, Missing); smooth muscle: 98.3529% (minimum 99%, Missing); spinal cord: 96.7593% (minimum 99%, Missing); spleen: 93.3036% (minimum 95%, Missing); stomach: 87.6310% (minimum 97%, Missing); thyroid gland: 94.7846% (minimum 95%, Missing); urinary bladder: 96.0920% (minimum 97%, Missing)",-0.0190423,-0.0936897,-0.12278,0,80,unavailable,6.4,5.9,3.1,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 2); salivary gland: 4.3 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196074,SYCP2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.280958,0.17631,0.11722,0,80,unavailable,6.4,5.9,3.1,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 2); salivary gland: 4.3 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196074,SYCP2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.280958,0.17631,0.11722,0,80,unavailable,6.4,5.9,3.1,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 3); salivary gland: 4.3 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196074,SYCP2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.280958,0.17631,0.11722,0,80,unavailable,6.4,5.9,3.1,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 3); salivary gland: 4.3 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196074,SYCP2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.280958,0.17631,0.11722,0,80,unavailable,6.4,5.9,3.1,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 3); salivary gland: 4.3 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196074,SYCP2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 78.7234% (minimum 95%, Missing); adrenal gland: 94.8718% (minimum 99%, Missing); amygdala: 97.3684% (minimum 99%, Missing); basal ganglia: 94.8718% (minimum 99%, Missing); cerebral cortex: 77.0833% (minimum 99%, Missing); colon: 80.4348% (minimum 97%, Missing); duodenum: 97.3684% (minimum 99%, Missing); esophagus: 94.8718% (minimum 97%, Missing); heart muscle: 74.0000% (minimum 99%, Missing); hippocampal formation: 94.8718% (minimum 99%, Missing); hypothalamus: 94.8718% (minimum 99%, Missing); kidney: 71.1538% (minimum 99%, Missing); liver: 97.3684% (minimum 99%, Missing); lung: 94.8718% (minimum 99%, Missing); midbrain: 90.2439% (minimum 99%, Missing); pancreas: 78.7234% (minimum 99%, Missing); parathyroid gland: 50.6849% (minimum 97%, Missing); pituitary gland: 77.0833% (minimum 99%, Missing); rectum: 92.5000% (minimum 97%, Missing); retina: 92.5000% (minimum 99%, Missing); salivary gland: 92.5000% (minimum 97%, Missing); skeletal muscle: 97.3684% (minimum 99%, Missing); skin: 92.5000% (minimum 95%, Missing); small intestine: 92.5000% (minimum 99%, Missing); smooth muscle: 78.7234% (minimum 99%, Missing); spinal cord: 88.0952% (minimum 99%, Missing); spleen: 86.0465% (minimum 95%, Missing); stomach: 94.8718% (minimum 97%, Missing); thyroid gland: 53.6232% (minimum 95%, Missing); tongue: 92.5000% (minimum 97%, Missing); urinary bladder: 90.2439% (minimum 97%, Missing)",-0.413768,-0.463151,-0.278462,0,80,unavailable,1.5,3.6,3.2,"parathyroid gland: 3.6 nTPM (protected, limit 2); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196109,ZNF676,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 74.0000% (minimum 75%, Missing); kidney: 71.1538% (minimum 75%, Missing); parathyroid gland: 50.6849% (minimum 70%, Missing); thyroid gland: 53.6232% (minimum 65%, Missing)",-0.113768,-0.193151,-0.0384615,0,80,unavailable,1.5,3.6,3.2,"parathyroid gland: 3.6 nTPM (protected, limit 2); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196109,ZNF676,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 74.0000% (minimum 75%, Missing); kidney: 71.1538% (minimum 75%, Missing); parathyroid gland: 50.6849% (minimum 70%, Missing); thyroid gland: 53.6232% (minimum 65%, Missing)",-0.113768,-0.193151,-0.0384615,0,80,unavailable,1.5,3.6,3.2,"parathyroid gland: 3.6 nTPM (protected, limit 3); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196109,ZNF676,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 74.0000% (minimum 75%, Missing); kidney: 71.1538% (minimum 75%, Missing); parathyroid gland: 50.6849% (minimum 70%, Missing); thyroid gland: 53.6232% (minimum 65%, Missing)",-0.113768,-0.193151,-0.0384615,0,80,unavailable,1.5,3.6,3.2,"parathyroid gland: 3.6 nTPM (protected, limit 3); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196109,ZNF676,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 74.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 71.1538% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.6849% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.6232% (minimum 65%, Baseline (adaptation disabled))",-0.113768,-0.193151,-0.0384615,0,80,unavailable,1.5,3.6,3.2,"parathyroid gland: 3.6 nTPM (protected, limit 3); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196109,ZNF676,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Missing); bone marrow: 25.0000% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); liver: 27.2727% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); pancreas: 60.0000% (minimum 99%, Missing); parathyroid gland: 60.0000% (minimum 97%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 37.5000% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 97%, Missing); skin: 33.3333% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spleen: 60.0000% (minimum 95%, Missing); stomach: 75.0000% (minimum 97%, Missing); thyroid gland: 75.0000% (minimum 95%, Missing)",-0.616667,-0.37,-0.74,0,80,unavailable,0.9,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196119,OR8A1,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); liver: 27.2727% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 60.0000% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); retina: 37.5000% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skin: 33.3333% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing)",-0.316667,-0.1,-0.5,0,80,unavailable,0.9,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196119,OR8A1,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); liver: 27.2727% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 60.0000% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); retina: 37.5000% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skin: 33.3333% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing)",-0.316667,-0.1,-0.5,0,80,unavailable,0.9,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196119,OR8A1,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); liver: 27.2727% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 60.0000% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); retina: 37.5000% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skin: 33.3333% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing)",-0.316667,-0.1,-0.5,0,80,unavailable,0.9,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196119,OR8A1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 27.2727% (minimum 75%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 60.0000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 37.5000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); skin: 33.3333% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.0000% (minimum 65%, Baseline (adaptation disabled))",-0.316667,-0.1,-0.5,0,80,unavailable,0.9,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196119,OR8A1,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 80.0000% (minimum 99%, Missing); bone marrow: 77.4194% (minimum 99%, Missing); cerebellum: 54.5455% (minimum 99%, Missing); cerebral cortex: 51.0638% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 72.7273% (minimum 99%, Missing); esophagus: 55.8140% (minimum 97%, Missing); heart muscle: 85.7143% (minimum 99%, Missing); hippocampal formation: 77.4194% (minimum 99%, Missing); hypothalamus: 70.5882% (minimum 99%, Missing); kidney: 77.4194% (minimum 99%, Missing); liver: 92.3077% (minimum 99%, Missing); lung: 72.7273% (minimum 99%, Missing); lymph node: 47.0588% (minimum 97%, Missing); midbrain: 77.4194% (minimum 99%, Missing); pancreas: 57.1429% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 57.1429% (minimum 97%, Missing); retina: 72.7273% (minimum 99%, Missing); salivary gland: 82.7586% (minimum 97%, Missing); skeletal muscle: 96.0000% (minimum 99%, Missing); skin: 53.3333% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 57.1429% (minimum 95%, Missing); stomach: 70.5882% (minimum 97%, Missing); thymus: 38.7097% (minimum 95%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); tongue: 92.3077% (minimum 97%, Missing); urinary bladder: 61.5385% (minimum 97%, Missing)",-0.562903,-0.499412,-0.479362,0,80,unavailable,2.3,2.7,3.8,"lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196172,ZNF681,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); cerebellum: 54.5455% (minimum 75%, Missing); cerebral cortex: 51.0638% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 72.7273% (minimum 75%, Missing); esophagus: 55.8140% (minimum 70%, Missing); hypothalamus: 70.5882% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); lymph node: 47.0588% (minimum 70%, Missing); pancreas: 57.1429% (minimum 75%, Missing); rectum: 57.1429% (minimum 70%, Missing); retina: 72.7273% (minimum 75%, Missing); skin: 53.3333% (minimum 65%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); thymus: 38.7097% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); urinary bladder: 61.5385% (minimum 70%, Missing)",-0.262903,-0.229412,-0.239362,0,80,unavailable,2.3,2.7,3.8,"lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196172,ZNF681,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); cerebellum: 54.5455% (minimum 75%, Missing); cerebral cortex: 51.0638% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 72.7273% (minimum 75%, Missing); esophagus: 55.8140% (minimum 70%, Missing); hypothalamus: 70.5882% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); lymph node: 47.0588% (minimum 70%, Missing); pancreas: 57.1429% (minimum 75%, Missing); rectum: 57.1429% (minimum 70%, Missing); retina: 72.7273% (minimum 75%, Missing); skin: 53.3333% (minimum 65%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); thymus: 38.7097% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); urinary bladder: 61.5385% (minimum 70%, Missing)",-0.262903,-0.229412,-0.239362,0,80,unavailable,2.3,2.7,3.8,"cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196172,ZNF681,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); cerebellum: 54.5455% (minimum 75%, Missing); cerebral cortex: 51.0638% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 72.7273% (minimum 75%, Missing); esophagus: 55.8140% (minimum 70%, Missing); hypothalamus: 70.5882% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); lymph node: 47.0588% (minimum 70%, Missing); pancreas: 57.1429% (minimum 75%, Missing); rectum: 57.1429% (minimum 70%, Missing); retina: 72.7273% (minimum 75%, Missing); skin: 53.3333% (minimum 65%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); thymus: 38.7097% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); urinary bladder: 61.5385% (minimum 70%, Missing)",-0.262903,-0.229412,-0.239362,0,80,unavailable,2.3,2.7,3.8,"cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196172,ZNF681,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.5455% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.0638% (minimum 75%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.7273% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.8140% (minimum 70%, Baseline (adaptation disabled)); hypothalamus: 70.5882% (minimum 75%, Baseline (adaptation disabled)); lung: 72.7273% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.0588% (minimum 70%, Baseline (adaptation disabled)); pancreas: 57.1429% (minimum 75%, Baseline (adaptation disabled)); rectum: 57.1429% (minimum 70%, Baseline (adaptation disabled)); retina: 72.7273% (minimum 75%, Baseline (adaptation disabled)); skin: 53.3333% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.1429% (minimum 65%, Baseline (adaptation disabled)); thymus: 38.7097% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 61.5385% (minimum 70%, Baseline (adaptation disabled))",-0.262903,-0.229412,-0.239362,0,80,unavailable,2.3,2.7,3.8,"cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196172,ZNF681,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196184,OR10J1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196184,OR10J1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196184,OR10J1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196184,OR10J1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196184,OR10J1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.5506% (minimum 95%, Missing); adrenal gland: 63.8554% (minimum 99%, Missing); amygdala: 64.6341% (minimum 99%, Missing); basal ganglia: 64.6341% (minimum 99%, Missing); bone marrow: 17.3770% (minimum 99%, Missing); cerebellum: 45.2991% (minimum 99%, Missing); cerebral cortex: 58.8889% (minimum 99%, Missing); choroid plexus: 75.7143% (minimum 99%, Missing); colon: 38.6861% (minimum 97%, Missing); duodenum: 32.7160% (minimum 99%, Missing); esophagus: 43.8017% (minimum 97%, Missing); heart muscle: 59.5506% (minimum 99%, Missing); hippocampal formation: 60.9195% (minimum 99%, Missing); hypothalamus: 62.3529% (minimum 99%, Missing); kidney: 50.9615% (minimum 99%, Missing); liver: 48.1818% (minimum 99%, Missing); lung: 53.0000% (minimum 99%, Missing); lymph node: 46.4912% (minimum 97%, Missing); midbrain: 60.9195% (minimum 99%, Missing); pancreas: 40.1515% (minimum 99%, Missing); parathyroid gland: 55.7895% (minimum 97%, Missing); pituitary gland: 50.9615% (minimum 99%, Missing); rectum: 38.9706% (minimum 97%, Missing); retina: 25.7282% (minimum 99%, Missing); salivary gland: 49.5327% (minimum 97%, Missing); skeletal muscle: 37.3239% (minimum 99%, Missing); skin: 56.9892% (minimum 95%, Missing); small intestine: 33.7580% (minimum 99%, Missing); smooth muscle: 62.3529% (minimum 99%, Missing); spinal cord: 51.4563% (minimum 99%, Missing); spleen: 49.5327% (minimum 95%, Missing); stomach: 39.5522% (minimum 97%, Missing); thymus: 47.7477% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 51.9608% (minimum 97%, Missing); urinary bladder: 44.9153% (minimum 97%, Missing)",-0.472523,-0.583139,-0.81623,0,2,partial,25.2,8.4,5.8,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 2); rectum: 8.3 nTPM (protected, limit 2); stomach: 8.1 nTPM (protected, limit 2); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 2); urinary bladder: 6.5 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); thymus: 5.8 nTPM (manageable, limit 5); liver: 5.7 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 5.4 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 2); lung: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196233,LCOR,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.5506% (minimum 65%, Missing); adrenal gland: 63.8554% (minimum 75%, Missing); amygdala: 64.6341% (minimum 75%, Missing); basal ganglia: 64.6341% (minimum 75%, Missing); bone marrow: 17.3770% (minimum 75%, Missing); cerebellum: 45.2991% (minimum 75%, Missing); cerebral cortex: 58.8889% (minimum 75%, Missing); colon: 38.6861% (minimum 70%, Missing); duodenum: 32.7160% (minimum 75%, Missing); esophagus: 43.8017% (minimum 70%, Missing); heart muscle: 59.5506% (minimum 75%, Missing); hippocampal formation: 60.9195% (minimum 75%, Missing); hypothalamus: 62.3529% (minimum 75%, Missing); kidney: 50.9615% (minimum 75%, Missing); liver: 48.1818% (minimum 75%, Missing); lung: 53.0000% (minimum 75%, Missing); lymph node: 46.4912% (minimum 70%, Missing); midbrain: 60.9195% (minimum 75%, Missing); pancreas: 40.1515% (minimum 75%, Missing); parathyroid gland: 55.7895% (minimum 70%, Missing); pituitary gland: 50.9615% (minimum 75%, Missing); rectum: 38.9706% (minimum 70%, Missing); retina: 25.7282% (minimum 75%, Missing); salivary gland: 49.5327% (minimum 70%, Missing); skeletal muscle: 37.3239% (minimum 75%, Missing); skin: 56.9892% (minimum 65%, Missing); small intestine: 33.7580% (minimum 75%, Missing); smooth muscle: 62.3529% (minimum 75%, Missing); spinal cord: 51.4563% (minimum 75%, Missing); spleen: 49.5327% (minimum 65%, Missing); stomach: 39.5522% (minimum 70%, Missing); thymus: 47.7477% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 51.9608% (minimum 70%, Missing); urinary bladder: 44.9153% (minimum 70%, Missing)",-0.172523,-0.313139,-0.57623,0,2,partial,25.2,8.4,5.8,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 2); rectum: 8.3 nTPM (protected, limit 2); stomach: 8.1 nTPM (protected, limit 2); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 2); urinary bladder: 6.5 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); thymus: 5.8 nTPM (manageable, limit 5); liver: 5.7 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 5.4 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 2); lung: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196233,LCOR,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.5506% (minimum 65%, Missing); adrenal gland: 63.8554% (minimum 75%, Missing); amygdala: 64.6341% (minimum 75%, Missing); basal ganglia: 64.6341% (minimum 75%, Missing); bone marrow: 17.3770% (minimum 75%, Missing); cerebellum: 45.2991% (minimum 75%, Missing); cerebral cortex: 58.8889% (minimum 75%, Missing); colon: 38.6861% (minimum 70%, Missing); duodenum: 32.7160% (minimum 75%, Missing); esophagus: 43.8017% (minimum 70%, Missing); heart muscle: 59.5506% (minimum 75%, Missing); hippocampal formation: 60.9195% (minimum 75%, Missing); hypothalamus: 62.3529% (minimum 75%, Missing); kidney: 50.9615% (minimum 75%, Missing); liver: 48.1818% (minimum 75%, Missing); lung: 53.0000% (minimum 75%, Missing); lymph node: 46.4912% (minimum 70%, Missing); midbrain: 60.9195% (minimum 75%, Missing); pancreas: 40.1515% (minimum 75%, Missing); parathyroid gland: 55.7895% (minimum 70%, Missing); pituitary gland: 50.9615% (minimum 75%, Missing); rectum: 38.9706% (minimum 70%, Missing); retina: 25.7282% (minimum 75%, Missing); salivary gland: 49.5327% (minimum 70%, Missing); skeletal muscle: 37.3239% (minimum 75%, Missing); skin: 56.9892% (minimum 65%, Missing); small intestine: 33.7580% (minimum 75%, Missing); smooth muscle: 62.3529% (minimum 75%, Missing); spinal cord: 51.4563% (minimum 75%, Missing); spleen: 49.5327% (minimum 65%, Missing); stomach: 39.5522% (minimum 70%, Missing); thymus: 47.7477% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 51.9608% (minimum 70%, Missing); urinary bladder: 44.9153% (minimum 70%, Missing)",-0.172523,-0.313139,-0.57623,0,2,partial,25.2,8.4,5.8,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 3); rectum: 8.3 nTPM (protected, limit 3); stomach: 8.1 nTPM (protected, limit 3); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 3); urinary bladder: 6.5 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 3); thymus: 5.8 nTPM (manageable, limit 5); liver: 5.7 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 5.4 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 3); lung: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196233,LCOR,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.5506% (minimum 65%, Missing); adrenal gland: 63.8554% (minimum 75%, Missing); amygdala: 64.6341% (minimum 75%, Missing); basal ganglia: 64.6341% (minimum 75%, Missing); bone marrow: 17.3770% (minimum 75%, Missing); cerebellum: 45.2991% (minimum 75%, Missing); cerebral cortex: 58.8889% (minimum 75%, Missing); colon: 38.6861% (minimum 70%, Missing); duodenum: 32.7160% (minimum 75%, Missing); esophagus: 43.8017% (minimum 70%, Missing); heart muscle: 59.5506% (minimum 75%, Missing); hippocampal formation: 60.9195% (minimum 75%, Missing); hypothalamus: 62.3529% (minimum 75%, Missing); kidney: 50.9615% (minimum 75%, Missing); liver: 48.1818% (minimum 75%, Missing); lung: 53.0000% (minimum 75%, Missing); lymph node: 46.4912% (minimum 70%, Missing); midbrain: 60.9195% (minimum 75%, Missing); pancreas: 40.1515% (minimum 75%, Missing); parathyroid gland: 55.7895% (minimum 70%, Missing); pituitary gland: 50.9615% (minimum 75%, Missing); rectum: 38.9706% (minimum 70%, Missing); retina: 25.7282% (minimum 75%, Missing); salivary gland: 49.5327% (minimum 70%, Missing); skeletal muscle: 37.3239% (minimum 75%, Missing); skin: 56.9892% (minimum 65%, Missing); small intestine: 33.7580% (minimum 75%, Missing); smooth muscle: 62.3529% (minimum 75%, Missing); spinal cord: 51.4563% (minimum 75%, Missing); spleen: 49.5327% (minimum 65%, Missing); stomach: 39.5522% (minimum 70%, Missing); thymus: 47.7477% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 51.9608% (minimum 70%, Missing); urinary bladder: 44.9153% (minimum 70%, Missing)",-0.172523,-0.313139,-0.57623,0,2,partial,25.2,8.4,5.8,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 3); rectum: 8.3 nTPM (protected, limit 3); stomach: 8.1 nTPM (protected, limit 3); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 3); urinary bladder: 6.5 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 3); thymus: 5.8 nTPM (manageable, limit 5); liver: 5.7 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 5.4 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 3); lung: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196233,LCOR,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.5506% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.8554% (minimum 75%, Baseline (adaptation disabled)); amygdala: 64.6341% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.6341% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 17.3770% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 45.2991% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.8889% (minimum 75%, Baseline (adaptation disabled)); colon: 38.6861% (minimum 70%, Baseline (adaptation disabled)); duodenum: 32.7160% (minimum 75%, Baseline (adaptation disabled)); esophagus: 43.8017% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.5506% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 60.9195% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.3529% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.9615% (minimum 75%, Baseline (adaptation disabled)); liver: 48.1818% (minimum 75%, Baseline (adaptation disabled)); lung: 53.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 46.4912% (minimum 70%, Baseline (adaptation disabled)); midbrain: 60.9195% (minimum 75%, Baseline (adaptation disabled)); pancreas: 40.1515% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.7895% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 50.9615% (minimum 75%, Baseline (adaptation disabled)); rectum: 38.9706% (minimum 70%, Baseline (adaptation disabled)); retina: 25.7282% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 49.5327% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 37.3239% (minimum 75%, Baseline (adaptation disabled)); skin: 56.9892% (minimum 65%, Baseline (adaptation disabled)); small intestine: 33.7580% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.3529% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 51.4563% (minimum 75%, Baseline (adaptation disabled)); spleen: 49.5327% (minimum 65%, Baseline (adaptation disabled)); stomach: 39.5522% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.7477% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 51.9608% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 44.9153% (minimum 70%, Baseline (adaptation disabled))",-0.172523,-0.313139,-0.57623,0,2,partial,25.2,8.4,5.8,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 3); rectum: 8.3 nTPM (protected, limit 3); stomach: 8.1 nTPM (protected, limit 3); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 3); urinary bladder: 6.5 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 3); thymus: 5.8 nTPM (manageable, limit 5); liver: 5.7 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 5.4 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 3); lung: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196233,LCOR,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 87.5000% (minimum 99%, Missing); pancreas: 87.5000% (minimum 99%, Missing); retina: 63.6364% (minimum 99%, Missing); skeletal muscle: 87.5000% (minimum 99%, Missing); smooth muscle: 87.5000% (minimum 99%, Missing); thymus: 87.5000% (minimum 95%, Missing)",-0.075,0.03,-0.353636,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196242,OR2C3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 63.6364% (minimum 75%, Missing)",0.225,0.3,-0.113636,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196242,OR2C3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 63.6364% (minimum 75%, Missing)",0.225,0.3,-0.113636,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196242,OR2C3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 63.6364% (minimum 75%, Missing)",0.225,0.3,-0.113636,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196242,OR2C3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 63.6364% (minimum 75%, Baseline (adaptation disabled))",0.225,0.3,-0.113636,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196242,OR2C3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.2622% (minimum 99%, Missing)",0.0467949,0.0236102,-0.00737757,0,4,partial,1.3,0.4,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196335,STK31,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346795,0.29361,0.232622,0,4,partial,1.3,0.4,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196335,STK31,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346795,0.29361,0.232622,0,4,partial,1.3,0.4,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196335,STK31,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346795,0.29361,0.232622,0,4,partial,1.3,0.4,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196335,STK31,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346795,0.29361,0.229528,0,4,partial,1.3,0.4,0.2,"cerebellum: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196335,STK31,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 85.7143% (minimum 99%, Missing); choroid plexus: 85.7143% (minimum 99%, Missing); retina: 85.7143% (minimum 99%, Missing); skin: 85.7143% (minimum 95%, Missing)",-0.0928571,0.03,-0.132857,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196341,OR8D1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.207143,0.3,0.107143,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196341,OR8D1,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.207143,0.3,0.107143,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196341,OR8D1,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.207143,0.3,0.107143,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196341,OR8D1,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.207143,0.3,0.107143,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196341,OR8D1,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196350,ZNF729,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196350,ZNF729,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196350,ZNF729,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196350,ZNF729,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196350,ZNF729,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.2128% (minimum 95%, Missing); adrenal gland: 72.5275% (minimum 99%, Missing); amygdala: 68.0412% (minimum 99%, Missing); basal ganglia: 67.3469% (minimum 99%, Missing); bone marrow: 64.7059% (minimum 99%, Missing); cerebellum: 70.9677% (minimum 99%, Missing); cerebral cortex: 65.3465% (minimum 99%, Missing); choroid plexus: 64.0777% (minimum 99%, Missing); colon: 73.3333% (minimum 97%, Missing); duodenum: 76.7442% (minimum 99%, Missing); esophagus: 74.1573% (minimum 97%, Missing); heart muscle: 74.1573% (minimum 99%, Missing); hippocampal formation: 67.3469% (minimum 99%, Missing); hypothalamus: 68.0412% (minimum 99%, Missing); kidney: 73.3333% (minimum 99%, Missing); liver: 69.4737% (minimum 99%, Missing); lung: 75.8621% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 66.0000% (minimum 99%, Missing); pancreas: 73.3333% (minimum 99%, Missing); parathyroid gland: 70.2128% (minimum 97%, Missing); pituitary gland: 71.7391% (minimum 99%, Missing); rectum: 71.7391% (minimum 97%, Missing); retina: 66.0000% (minimum 99%, Missing); salivary gland: 64.7059% (minimum 97%, Missing); skeletal muscle: 62.2642% (minimum 99%, Missing); skin: 68.7500% (minimum 95%, Missing); small intestine: 77.6471% (minimum 99%, Missing); smooth muscle: 70.2128% (minimum 99%, Missing); spinal cord: 61.1111% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 69.4737% (minimum 97%, Missing); thymus: 75.8621% (minimum 95%, Missing); thyroid gland: 68.7500% (minimum 95%, Missing); tongue: 60.0000% (minimum 97%, Missing); urinary bladder: 71.7391% (minimum 97%, Missing)",-0.2625,-0.37,-0.378889,0,80,unavailable,4.2,4.4,3,"tongue: 4.4 nTPM (protected, limit 2); spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); bone marrow: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); lymph node: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196357,ZNF565,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.5275% (minimum 75%, Missing); amygdala: 68.0412% (minimum 75%, Missing); basal ganglia: 67.3469% (minimum 75%, Missing); bone marrow: 64.7059% (minimum 75%, Missing); cerebellum: 70.9677% (minimum 75%, Missing); cerebral cortex: 65.3465% (minimum 75%, Missing); choroid plexus: 64.0777% (minimum 75%, Missing); heart muscle: 74.1573% (minimum 75%, Missing); hippocampal formation: 67.3469% (minimum 75%, Missing); hypothalamus: 68.0412% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); liver: 69.4737% (minimum 75%, Missing); midbrain: 66.0000% (minimum 75%, Missing); pancreas: 73.3333% (minimum 75%, Missing); pituitary gland: 71.7391% (minimum 75%, Missing); retina: 66.0000% (minimum 75%, Missing); salivary gland: 64.7059% (minimum 70%, Missing); skeletal muscle: 62.2642% (minimum 75%, Missing); smooth muscle: 70.2128% (minimum 75%, Missing); spinal cord: 61.1111% (minimum 75%, Missing); stomach: 69.4737% (minimum 70%, Missing); tongue: 60.0000% (minimum 70%, Missing)",0.0375,-0.1,-0.138889,0,80,unavailable,4.2,4.4,3,"tongue: 4.4 nTPM (protected, limit 2); spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); bone marrow: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); lymph node: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196357,ZNF565,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.5275% (minimum 75%, Missing); amygdala: 68.0412% (minimum 75%, Missing); basal ganglia: 67.3469% (minimum 75%, Missing); bone marrow: 64.7059% (minimum 75%, Missing); cerebellum: 70.9677% (minimum 75%, Missing); cerebral cortex: 65.3465% (minimum 75%, Missing); choroid plexus: 64.0777% (minimum 75%, Missing); heart muscle: 74.1573% (minimum 75%, Missing); hippocampal formation: 67.3469% (minimum 75%, Missing); hypothalamus: 68.0412% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); liver: 69.4737% (minimum 75%, Missing); midbrain: 66.0000% (minimum 75%, Missing); pancreas: 73.3333% (minimum 75%, Missing); pituitary gland: 71.7391% (minimum 75%, Missing); retina: 66.0000% (minimum 75%, Missing); salivary gland: 64.7059% (minimum 70%, Missing); skeletal muscle: 62.2642% (minimum 75%, Missing); smooth muscle: 70.2128% (minimum 75%, Missing); spinal cord: 61.1111% (minimum 75%, Missing); stomach: 69.4737% (minimum 70%, Missing); tongue: 60.0000% (minimum 70%, Missing)",0.0375,-0.1,-0.138889,0,80,unavailable,4.2,4.4,3,"tongue: 4.4 nTPM (protected, limit 3); spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196357,ZNF565,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.5275% (minimum 75%, Missing); amygdala: 68.0412% (minimum 75%, Missing); basal ganglia: 67.3469% (minimum 75%, Missing); bone marrow: 64.7059% (minimum 75%, Missing); cerebellum: 70.9677% (minimum 75%, Missing); cerebral cortex: 65.3465% (minimum 75%, Missing); choroid plexus: 64.0777% (minimum 75%, Missing); heart muscle: 74.1573% (minimum 75%, Missing); hippocampal formation: 67.3469% (minimum 75%, Missing); hypothalamus: 68.0412% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); liver: 69.4737% (minimum 75%, Missing); midbrain: 66.0000% (minimum 75%, Missing); pancreas: 73.3333% (minimum 75%, Missing); pituitary gland: 71.7391% (minimum 75%, Missing); retina: 66.0000% (minimum 75%, Missing); salivary gland: 64.7059% (minimum 70%, Missing); skeletal muscle: 62.2642% (minimum 75%, Missing); smooth muscle: 70.2128% (minimum 75%, Missing); spinal cord: 61.1111% (minimum 75%, Missing); stomach: 69.4737% (minimum 70%, Missing); tongue: 60.0000% (minimum 70%, Missing)",0.0375,-0.1,-0.138889,0,80,unavailable,4.2,4.4,3,"tongue: 4.4 nTPM (protected, limit 3); spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196357,ZNF565,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.5275% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.0412% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 67.3469% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 64.7059% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.9677% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.3465% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.0777% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 74.1573% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.3469% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.0412% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.3333% (minimum 75%, Baseline (adaptation disabled)); liver: 69.4737% (minimum 75%, Baseline (adaptation disabled)); midbrain: 66.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.3333% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 71.7391% (minimum 75%, Baseline (adaptation disabled)); retina: 66.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.7059% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 62.2642% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.2128% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.1111% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.4737% (minimum 70%, Baseline (adaptation disabled)); tongue: 60.0000% (minimum 70%, Baseline (adaptation disabled))",0.0375,-0.1,-0.138889,0,80,unavailable,4.2,4.4,3,"tongue: 4.4 nTPM (protected, limit 3); spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196357,ZNF565,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.3089% (minimum 95%, Missing); adrenal gland: 92.8000% (minimum 99%, Missing); amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 93.9271% (minimum 99%, Missing); bone marrow: 96.6667% (minimum 99%, Missing); cerebellum: 94.6939% (minimum 99%, Missing); cerebral cortex: 87.0544% (minimum 99%, Missing); choroid plexus: 93.3602% (minimum 99%, Missing); colon: 93.5484% (minimum 97%, Missing); duodenum: 81.6901% (minimum 99%, Missing); esophagus: 90.4483% (minimum 97%, Missing); heart muscle: 88.2129% (minimum 99%, Missing); hippocampal formation: 92.0635% (minimum 99%, Missing); hypothalamus: 94.6939% (minimum 99%, Missing); kidney: 92.2465% (minimum 99%, Missing); liver: 92.6148% (minimum 99%, Missing); lung: 91.3386% (minimum 99%, Missing); lymph node: 84.8263% (minimum 97%, Missing); midbrain: 93.3602% (minimum 99%, Missing); pancreas: 92.4303% (minimum 99%, Missing); parathyroid gland: 96.8685% (minimum 97%, Missing); pituitary gland: 95.4733% (minimum 99%, Missing); retina: 91.5187% (minimum 99%, Missing); salivary gland: 89.4027% (minimum 97%, Missing); skeletal muscle: 81.6901% (minimum 99%, Missing); skin: 85.9259% (minimum 95%, Missing); small intestine: 85.9259% (minimum 99%, Missing); smooth muscle: 95.6701% (minimum 99%, Missing); spinal cord: 92.6148% (minimum 99%, Missing); spleen: 86.7290% (minimum 95%, Missing); stomach: 90.6250% (minimum 97%, Missing); thyroid gland: 85.7671% (minimum 95%, Missing); tongue: 90.9804% (minimum 97%, Missing); urinary bladder: 94.6939% (minimum 97%, Missing)",-0.092329,-0.121737,-0.173099,0,80,unavailable,10.4,8.3,7.7,"duodenum: 10.4 nTPM (vital, limit 1); skeletal muscle: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 2); thyroid gland: 7.7 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.1 nTPM (manageable, limit 5); cerebral cortex: 6.9 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); esophagus: 4.9 nTPM (protected, limit 2); stomach: 4.8 nTPM (protected, limit 2); tongue: 4.6 nTPM (protected, limit 2); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196388,INCA1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.207671,0.148263,0.0669014,0,80,unavailable,10.4,8.3,7.7,"duodenum: 10.4 nTPM (vital, limit 1); skeletal muscle: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 2); thyroid gland: 7.7 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.1 nTPM (manageable, limit 5); cerebral cortex: 6.9 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); esophagus: 4.9 nTPM (protected, limit 2); stomach: 4.8 nTPM (protected, limit 2); tongue: 4.6 nTPM (protected, limit 2); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196388,INCA1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.207671,0.148263,0.0669014,0,80,unavailable,10.4,8.3,7.7,"duodenum: 10.4 nTPM (vital, limit 1); skeletal muscle: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 3); thyroid gland: 7.7 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); spleen: 7.1 nTPM (manageable, limit 5); cerebral cortex: 6.9 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); esophagus: 4.9 nTPM (protected, limit 3); stomach: 4.8 nTPM (protected, limit 3); tongue: 4.6 nTPM (protected, limit 3); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196388,INCA1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.207671,0.148263,0.0669014,0,80,unavailable,10.4,8.3,7.7,"duodenum: 10.4 nTPM (vital, limit 1); skeletal muscle: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 3); thyroid gland: 7.7 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); spleen: 7.1 nTPM (manageable, limit 5); cerebral cortex: 6.9 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); esophagus: 4.9 nTPM (protected, limit 3); stomach: 4.8 nTPM (protected, limit 3); tongue: 4.6 nTPM (protected, limit 3); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196388,INCA1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.207671,0.148263,0.0669014,0,80,unavailable,10.4,8.3,7.7,"duodenum: 10.4 nTPM (vital, limit 1); skeletal muscle: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 3); thyroid gland: 7.7 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); spleen: 7.1 nTPM (manageable, limit 5); cerebral cortex: 6.9 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); esophagus: 4.9 nTPM (protected, limit 3); stomach: 4.8 nTPM (protected, limit 3); tongue: 4.6 nTPM (protected, limit 3); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196388,INCA1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.7097% (minimum 95%, Missing); adrenal gland: 67.9012% (minimum 99%, Missing); amygdala: 71.4286% (minimum 99%, Missing); basal ganglia: 61.1111% (minimum 99%, Missing); bone marrow: 83.3333% (minimum 99%, Missing); cerebellum: 51.8868% (minimum 99%, Missing); cerebral cortex: 54.4554% (minimum 99%, Missing); choroid plexus: 85.9375% (minimum 99%, Missing); colon: 55.5556% (minimum 97%, Missing); duodenum: 70.5128% (minimum 99%, Missing); esophagus: 80.8824% (minimum 97%, Missing); heart muscle: 67.0732% (minimum 99%, Missing); hippocampal formation: 73.3333% (minimum 99%, Missing); hypothalamus: 64.7059% (minimum 99%, Missing); kidney: 80.8824% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 87.3016% (minimum 97%, Missing); midbrain: 71.4286% (minimum 99%, Missing); pancreas: 59.1398% (minimum 99%, Missing); parathyroid gland: 64.7059% (minimum 97%, Missing); pituitary gland: 65.4762% (minimum 99%, Missing); rectum: 44.7154% (minimum 97%, Missing); retina: 57.2917% (minimum 99%, Missing); salivary gland: 59.1398% (minimum 97%, Missing); skeletal muscle: 48.2456% (minimum 99%, Missing); skin: 64.7059% (minimum 95%, Missing); small intestine: 73.3333% (minimum 99%, Missing); smooth muscle: 76.3889% (minimum 99%, Missing); spinal cord: 76.3889% (minimum 99%, Missing); spleen: 90.1639% (minimum 95%, Missing); stomach: 67.9012% (minimum 97%, Missing); thymus: 78.5714% (minimum 95%, Missing); thyroid gland: 67.0732% (minimum 95%, Missing); tongue: 44.3548% (minimum 97%, Missing); urinary bladder: 75.3425% (minimum 97%, Missing)",-0.302941,-0.526452,-0.507544,0,80,unavailable,5.9,6.9,3,"tongue: 6.9 nTPM (protected, limit 2); rectum: 6.8 nTPM (protected, limit 2); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196391,ZNF774,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9012% (minimum 75%, Missing); amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 61.1111% (minimum 75%, Missing); cerebellum: 51.8868% (minimum 75%, Missing); cerebral cortex: 54.4554% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 70.5128% (minimum 75%, Missing); heart muscle: 67.0732% (minimum 75%, Missing); hippocampal formation: 73.3333% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); midbrain: 71.4286% (minimum 75%, Missing); pancreas: 59.1398% (minimum 75%, Missing); parathyroid gland: 64.7059% (minimum 70%, Missing); pituitary gland: 65.4762% (minimum 75%, Missing); rectum: 44.7154% (minimum 70%, Missing); retina: 57.2917% (minimum 75%, Missing); salivary gland: 59.1398% (minimum 70%, Missing); skeletal muscle: 48.2456% (minimum 75%, Missing); skin: 64.7059% (minimum 65%, Missing); small intestine: 73.3333% (minimum 75%, Missing); stomach: 67.9012% (minimum 70%, Missing); tongue: 44.3548% (minimum 70%, Missing)",-0.00294118,-0.256452,-0.267544,0,80,unavailable,5.9,6.9,3,"tongue: 6.9 nTPM (protected, limit 2); rectum: 6.8 nTPM (protected, limit 2); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196391,ZNF774,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9012% (minimum 75%, Missing); amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 61.1111% (minimum 75%, Missing); cerebellum: 51.8868% (minimum 75%, Missing); cerebral cortex: 54.4554% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 70.5128% (minimum 75%, Missing); heart muscle: 67.0732% (minimum 75%, Missing); hippocampal formation: 73.3333% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); midbrain: 71.4286% (minimum 75%, Missing); pancreas: 59.1398% (minimum 75%, Missing); parathyroid gland: 64.7059% (minimum 70%, Missing); pituitary gland: 65.4762% (minimum 75%, Missing); rectum: 44.7154% (minimum 70%, Missing); retina: 57.2917% (minimum 75%, Missing); salivary gland: 59.1398% (minimum 70%, Missing); skeletal muscle: 48.2456% (minimum 75%, Missing); skin: 64.7059% (minimum 65%, Missing); small intestine: 73.3333% (minimum 75%, Missing); stomach: 67.9012% (minimum 70%, Missing); tongue: 44.3548% (minimum 70%, Missing)",-0.00294118,-0.256452,-0.267544,0,80,unavailable,5.9,6.9,3,"tongue: 6.9 nTPM (protected, limit 3); rectum: 6.8 nTPM (protected, limit 3); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196391,ZNF774,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9012% (minimum 75%, Missing); amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 61.1111% (minimum 75%, Missing); cerebellum: 51.8868% (minimum 75%, Missing); cerebral cortex: 54.4554% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 70.5128% (minimum 75%, Missing); heart muscle: 67.0732% (minimum 75%, Missing); hippocampal formation: 73.3333% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); midbrain: 71.4286% (minimum 75%, Missing); pancreas: 59.1398% (minimum 75%, Missing); parathyroid gland: 64.7059% (minimum 70%, Missing); pituitary gland: 65.4762% (minimum 75%, Missing); rectum: 44.7154% (minimum 70%, Missing); retina: 57.2917% (minimum 75%, Missing); salivary gland: 59.1398% (minimum 70%, Missing); skeletal muscle: 48.2456% (minimum 75%, Missing); skin: 64.7059% (minimum 65%, Missing); small intestine: 73.3333% (minimum 75%, Missing); stomach: 67.9012% (minimum 70%, Missing); tongue: 44.3548% (minimum 70%, Missing)",-0.00294118,-0.256452,-0.267544,0,80,unavailable,5.9,6.9,3,"tongue: 6.9 nTPM (protected, limit 3); rectum: 6.8 nTPM (protected, limit 3); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196391,ZNF774,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9012% (minimum 75%, Baseline (adaptation disabled)); amygdala: 71.4286% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.1111% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 51.8868% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 54.4554% (minimum 75%, Baseline (adaptation disabled)); colon: 55.5556% (minimum 70%, Baseline (adaptation disabled)); duodenum: 70.5128% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 67.0732% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.7059% (minimum 75%, Baseline (adaptation disabled)); midbrain: 71.4286% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.1398% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.7059% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 65.4762% (minimum 75%, Baseline (adaptation disabled)); rectum: 44.7154% (minimum 70%, Baseline (adaptation disabled)); retina: 57.2917% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.1398% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 48.2456% (minimum 75%, Baseline (adaptation disabled)); skin: 64.7059% (minimum 65%, Baseline (adaptation disabled)); small intestine: 73.3333% (minimum 75%, Baseline (adaptation disabled)); stomach: 67.9012% (minimum 70%, Baseline (adaptation disabled)); tongue: 44.3548% (minimum 70%, Baseline (adaptation disabled))",-0.00294118,-0.256452,-0.267544,0,80,unavailable,5.9,6.9,3,"tongue: 6.9 nTPM (protected, limit 3); rectum: 6.8 nTPM (protected, limit 3); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196391,ZNF774,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196406,SPANXD,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196406,SPANXD,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196406,SPANXD,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196406,SPANXD,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196406,SPANXD,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.2381% (minimum 95%, Missing); adrenal gland: 68.1034% (minimum 99%, Missing); amygdala: 84.0426% (minimum 99%, Missing); basal ganglia: 84.9462% (minimum 99%, Missing); bone marrow: 65.8333% (minimum 99%, Missing); cerebellum: 84.9462% (minimum 99%, Missing); cerebral cortex: 84.9462% (minimum 99%, Missing); choroid plexus: 84.9462% (minimum 99%, Missing); colon: 70.5357% (minimum 97%, Missing); duodenum: 72.4771% (minimum 99%, Missing); esophagus: 75.9615% (minimum 97%, Missing); heart muscle: 80.6122% (minimum 99%, Missing); hippocampal formation: 84.0426% (minimum 99%, Missing); hypothalamus: 84.0426% (minimum 99%, Missing); kidney: 74.5283% (minimum 99%, Missing); liver: 80.6122% (minimum 99%, Missing); lung: 72.4771% (minimum 99%, Missing); lymph node: 67.5214% (minimum 97%, Missing); midbrain: 83.1579% (minimum 99%, Missing); pancreas: 64.2276% (minimum 99%, Missing); parathyroid gland: 48.1707% (minimum 97%, Missing); pituitary gland: 80.6122% (minimum 99%, Missing); rectum: 68.6957% (minimum 97%, Missing); retina: 79.7980% (minimum 99%, Missing); salivary gland: 74.5283% (minimum 97%, Missing); skeletal muscle: 82.2917% (minimum 99%, Missing); skin: 66.3866% (minimum 95%, Missing); small intestine: 74.5283% (minimum 99%, Missing); smooth muscle: 79.0000% (minimum 99%, Missing); spinal cord: 79.7980% (minimum 99%, Missing); spleen: 71.1712% (minimum 95%, Missing); stomach: 73.8318% (minimum 97%, Missing); thymus: 65.2893% (minimum 95%, Missing); thyroid gland: 71.8182% (minimum 95%, Missing); tongue: 84.0426% (minimum 97%, Missing); urinary bladder: 75.2381% (minimum 97%, Missing)",-0.297107,-0.488293,-0.347724,0,80,unavailable,4.4,8.5,4.2,"parathyroid gland: 8.5 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196417,ZNF765,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.1034% (minimum 75%, Missing); bone marrow: 65.8333% (minimum 75%, Missing); duodenum: 72.4771% (minimum 75%, Missing); kidney: 74.5283% (minimum 75%, Missing); lung: 72.4771% (minimum 75%, Missing); lymph node: 67.5214% (minimum 70%, Missing); pancreas: 64.2276% (minimum 75%, Missing); parathyroid gland: 48.1707% (minimum 70%, Missing); rectum: 68.6957% (minimum 70%, Missing); small intestine: 74.5283% (minimum 75%, Missing)",0.00289256,-0.218293,-0.107724,0,80,unavailable,4.4,8.5,4.2,"parathyroid gland: 8.5 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196417,ZNF765,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.1034% (minimum 75%, Missing); bone marrow: 65.8333% (minimum 75%, Missing); duodenum: 72.4771% (minimum 75%, Missing); kidney: 74.5283% (minimum 75%, Missing); lung: 72.4771% (minimum 75%, Missing); lymph node: 67.5214% (minimum 70%, Missing); pancreas: 64.2276% (minimum 75%, Missing); parathyroid gland: 48.1707% (minimum 70%, Missing); rectum: 68.6957% (minimum 70%, Missing); small intestine: 74.5283% (minimum 75%, Missing)",0.00289256,-0.218293,-0.107724,0,80,unavailable,4.4,8.5,4.2,"parathyroid gland: 8.5 nTPM (protected, limit 3); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196417,ZNF765,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.1034% (minimum 75%, Missing); bone marrow: 65.8333% (minimum 75%, Missing); duodenum: 72.4771% (minimum 75%, Missing); kidney: 74.5283% (minimum 75%, Missing); lung: 72.4771% (minimum 75%, Missing); lymph node: 67.5214% (minimum 70%, Missing); pancreas: 64.2276% (minimum 75%, Missing); parathyroid gland: 48.1707% (minimum 70%, Missing); rectum: 68.6957% (minimum 70%, Missing); small intestine: 74.5283% (minimum 75%, Missing)",0.00289256,-0.218293,-0.107724,0,80,unavailable,4.4,8.5,4.2,"parathyroid gland: 8.5 nTPM (protected, limit 3); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196417,ZNF765,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.1034% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 65.8333% (minimum 75%, Baseline (adaptation disabled)); duodenum: 72.4771% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.5283% (minimum 75%, Baseline (adaptation disabled)); lung: 72.4771% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.5214% (minimum 70%, Baseline (adaptation disabled)); pancreas: 64.2276% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 48.1707% (minimum 70%, Baseline (adaptation disabled)); rectum: 68.6957% (minimum 70%, Baseline (adaptation disabled)); small intestine: 74.5283% (minimum 75%, Baseline (adaptation disabled))",0.00289256,-0.218293,-0.107724,0,80,unavailable,4.4,8.5,4.2,"parathyroid gland: 8.5 nTPM (protected, limit 3); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196417,ZNF765,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.7119% (minimum 95%, Missing); adrenal gland: 66.0714% (minimum 99%, Missing); amygdala: 75.5102% (minimum 99%, Missing); basal ganglia: 77.0833% (minimum 99%, Missing); bone marrow: 45.1220% (minimum 99%, Missing); cerebellum: 68.5185% (minimum 99%, Missing); cerebral cortex: 69.8113% (minimum 99%, Missing); choroid plexus: 80.4348% (minimum 99%, Missing); colon: 38.1443% (minimum 97%, Missing); duodenum: 41.1111% (minimum 99%, Missing); esophagus: 68.5185% (minimum 97%, Missing); heart muscle: 68.5185% (minimum 99%, Missing); hippocampal formation: 72.5490% (minimum 99%, Missing); hypothalamus: 69.8113% (minimum 99%, Missing); kidney: 48.6842% (minimum 99%, Missing); liver: 57.8125% (minimum 99%, Missing); lung: 52.1127% (minimum 99%, Missing); lymph node: 42.0455% (minimum 97%, Missing); midbrain: 69.8113% (minimum 99%, Missing); pancreas: 52.8571% (minimum 99%, Missing); parathyroid gland: 74.0000% (minimum 97%, Missing); pituitary gland: 78.7234% (minimum 99%, Missing); rectum: 40.2174% (minimum 97%, Missing); retina: 54.4118% (minimum 99%, Missing); salivary gland: 63.7931% (minimum 97%, Missing); skeletal muscle: 71.1538% (minimum 99%, Missing); skin: 55.2239% (minimum 95%, Missing); small intestine: 41.5730% (minimum 99%, Missing); smooth muscle: 56.0606% (minimum 99%, Missing); spinal cord: 66.0714% (minimum 99%, Missing); spleen: 44.0476% (minimum 95%, Missing); stomach: 50.0000% (minimum 97%, Missing); thymus: 38.5417% (minimum 95%, Missing); thyroid gland: 56.0606% (minimum 95%, Missing); tongue: 75.5102% (minimum 97%, Missing); urinary bladder: 57.8125% (minimum 97%, Missing)",-0.564583,-0.588557,-0.578889,0,80,unavailable,5.3,6,5.9,"colon: 6 nTPM (protected, limit 2); thymus: 5.9 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); liver: 2.7 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196418,ZNF124,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.7119% (minimum 65%, Missing); adrenal gland: 66.0714% (minimum 75%, Missing); bone marrow: 45.1220% (minimum 75%, Missing); cerebellum: 68.5185% (minimum 75%, Missing); cerebral cortex: 69.8113% (minimum 75%, Missing); colon: 38.1443% (minimum 70%, Missing); duodenum: 41.1111% (minimum 75%, Missing); esophagus: 68.5185% (minimum 70%, Missing); heart muscle: 68.5185% (minimum 75%, Missing); hippocampal formation: 72.5490% (minimum 75%, Missing); hypothalamus: 69.8113% (minimum 75%, Missing); kidney: 48.6842% (minimum 75%, Missing); liver: 57.8125% (minimum 75%, Missing); lung: 52.1127% (minimum 75%, Missing); lymph node: 42.0455% (minimum 70%, Missing); midbrain: 69.8113% (minimum 75%, Missing); pancreas: 52.8571% (minimum 75%, Missing); rectum: 40.2174% (minimum 70%, Missing); retina: 54.4118% (minimum 75%, Missing); salivary gland: 63.7931% (minimum 70%, Missing); skeletal muscle: 71.1538% (minimum 75%, Missing); skin: 55.2239% (minimum 65%, Missing); small intestine: 41.5730% (minimum 75%, Missing); smooth muscle: 56.0606% (minimum 75%, Missing); spinal cord: 66.0714% (minimum 75%, Missing); spleen: 44.0476% (minimum 65%, Missing); stomach: 50.0000% (minimum 70%, Missing); thymus: 38.5417% (minimum 65%, Missing); thyroid gland: 56.0606% (minimum 65%, Missing); urinary bladder: 57.8125% (minimum 70%, Missing)",-0.264583,-0.318557,-0.338889,0,80,unavailable,5.3,6,5.9,"colon: 6 nTPM (protected, limit 2); thymus: 5.9 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); liver: 2.7 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196418,ZNF124,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.7119% (minimum 65%, Missing); adrenal gland: 66.0714% (minimum 75%, Missing); bone marrow: 45.1220% (minimum 75%, Missing); cerebellum: 68.5185% (minimum 75%, Missing); cerebral cortex: 69.8113% (minimum 75%, Missing); colon: 38.1443% (minimum 70%, Missing); duodenum: 41.1111% (minimum 75%, Missing); esophagus: 68.5185% (minimum 70%, Missing); heart muscle: 68.5185% (minimum 75%, Missing); hippocampal formation: 72.5490% (minimum 75%, Missing); hypothalamus: 69.8113% (minimum 75%, Missing); kidney: 48.6842% (minimum 75%, Missing); liver: 57.8125% (minimum 75%, Missing); lung: 52.1127% (minimum 75%, Missing); lymph node: 42.0455% (minimum 70%, Missing); midbrain: 69.8113% (minimum 75%, Missing); pancreas: 52.8571% (minimum 75%, Missing); rectum: 40.2174% (minimum 70%, Missing); retina: 54.4118% (minimum 75%, Missing); salivary gland: 63.7931% (minimum 70%, Missing); skeletal muscle: 71.1538% (minimum 75%, Missing); skin: 55.2239% (minimum 65%, Missing); small intestine: 41.5730% (minimum 75%, Missing); smooth muscle: 56.0606% (minimum 75%, Missing); spinal cord: 66.0714% (minimum 75%, Missing); spleen: 44.0476% (minimum 65%, Missing); stomach: 50.0000% (minimum 70%, Missing); thymus: 38.5417% (minimum 65%, Missing); thyroid gland: 56.0606% (minimum 65%, Missing); urinary bladder: 57.8125% (minimum 70%, Missing)",-0.264583,-0.318557,-0.338889,0,80,unavailable,5.3,6,5.9,"colon: 6 nTPM (protected, limit 3); thymus: 5.9 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196418,ZNF124,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.7119% (minimum 65%, Missing); adrenal gland: 66.0714% (minimum 75%, Missing); bone marrow: 45.1220% (minimum 75%, Missing); cerebellum: 68.5185% (minimum 75%, Missing); cerebral cortex: 69.8113% (minimum 75%, Missing); colon: 38.1443% (minimum 70%, Missing); duodenum: 41.1111% (minimum 75%, Missing); esophagus: 68.5185% (minimum 70%, Missing); heart muscle: 68.5185% (minimum 75%, Missing); hippocampal formation: 72.5490% (minimum 75%, Missing); hypothalamus: 69.8113% (minimum 75%, Missing); kidney: 48.6842% (minimum 75%, Missing); liver: 57.8125% (minimum 75%, Missing); lung: 52.1127% (minimum 75%, Missing); lymph node: 42.0455% (minimum 70%, Missing); midbrain: 69.8113% (minimum 75%, Missing); pancreas: 52.8571% (minimum 75%, Missing); rectum: 40.2174% (minimum 70%, Missing); retina: 54.4118% (minimum 75%, Missing); salivary gland: 63.7931% (minimum 70%, Missing); skeletal muscle: 71.1538% (minimum 75%, Missing); skin: 55.2239% (minimum 65%, Missing); small intestine: 41.5730% (minimum 75%, Missing); smooth muscle: 56.0606% (minimum 75%, Missing); spinal cord: 66.0714% (minimum 75%, Missing); spleen: 44.0476% (minimum 65%, Missing); stomach: 50.0000% (minimum 70%, Missing); thymus: 38.5417% (minimum 65%, Missing); thyroid gland: 56.0606% (minimum 65%, Missing); urinary bladder: 57.8125% (minimum 70%, Missing)",-0.264583,-0.318557,-0.338889,0,80,unavailable,5.3,6,5.9,"colon: 6 nTPM (protected, limit 3); thymus: 5.9 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196418,ZNF124,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.7119% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 66.0714% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 45.1220% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.5185% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 69.8113% (minimum 75%, Baseline (adaptation disabled)); colon: 38.1443% (minimum 70%, Baseline (adaptation disabled)); duodenum: 41.1111% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.5185% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 68.5185% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.5490% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.8113% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.6842% (minimum 75%, Baseline (adaptation disabled)); liver: 57.8125% (minimum 75%, Baseline (adaptation disabled)); lung: 52.1127% (minimum 75%, Baseline (adaptation disabled)); lymph node: 42.0455% (minimum 70%, Baseline (adaptation disabled)); midbrain: 69.8113% (minimum 75%, Baseline (adaptation disabled)); pancreas: 52.8571% (minimum 75%, Baseline (adaptation disabled)); rectum: 40.2174% (minimum 70%, Baseline (adaptation disabled)); retina: 54.4118% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.7931% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 71.1538% (minimum 75%, Baseline (adaptation disabled)); skin: 55.2239% (minimum 65%, Baseline (adaptation disabled)); small intestine: 41.5730% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.0606% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.0714% (minimum 75%, Baseline (adaptation disabled)); spleen: 44.0476% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 38.5417% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.0606% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 57.8125% (minimum 70%, Baseline (adaptation disabled))",-0.264583,-0.318557,-0.338889,0,80,unavailable,5.3,6,5.9,"colon: 6 nTPM (protected, limit 3); thymus: 5.9 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196418,ZNF124,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 93.4783% (minimum 99%, Missing); colon: 95.5556% (minimum 97%, Uncertain); duodenum: 97.7273% (minimum 99%, Uncertain); pituitary gland: 87.7551% (minimum 99%, Missing); rectum: 93.4783% (minimum 97%, Uncertain); small intestine: 79.6296% (minimum 99%, Uncertain)",0.00555556,-0.0352174,-0.193704,0,1,partial,1.1,0.3,0.2,"small intestine: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196427,NBPF4,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305556,0.234783,0.0462963,0,1,partial,1.1,0.3,0.2,"small intestine: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196427,NBPF4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305556,0.234783,0.0462963,0,1,partial,1.1,0.3,0.2,"small intestine: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196427,NBPF4,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305556,0.234783,0.0462963,0,1,partial,1.1,0.3,0.2,"small intestine: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196427,NBPF4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305556,0.234783,0.0462963,0,1,partial,1.1,0.3,0.2,"small intestine: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196427,NBPF4,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.3333% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); bone marrow: 93.3333% (minimum 97%, Supported); cerebral cortex: 93.3333% (minimum 97%, Supported); duodenum: 87.5000% (minimum 97%, Supported); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 93.3333% (minimum 99%, Missing); midbrain: 93.3333% (minimum 99%, Missing); thymus: 93.3333% (minimum 95%, Missing)",-0.0166667,0.03,-0.095,0,0,routine_complete,0.2,0.1,0.2,,eye / lens fiber cells: High (Supported),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196431,CRYBA4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.283333,0.3,0.183333,0,0,routine_complete,0.2,0.1,0.2,,eye / lens fiber cells: High (Supported),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196431,CRYBA4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.283333,0.3,0.183333,0,0,routine_complete,0.2,0.1,0.2,,eye / lens fiber cells: High (Supported),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196431,CRYBA4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.283333,0.3,0.183333,0,0,routine_complete,0.2,0.1,0.2,,eye / lens fiber cells: High (Supported),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196431,CRYBA4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.225,0.233333,0.125,0,0,routine_complete,0.2,0.1,0.2,,eye / lens fiber cells: High (Supported),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196431,CRYBA4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.8116% (minimum 95%, Missing); adrenal gland: 72.6027% (minimum 99%, Missing); amygdala: 75.1773% (minimum 99%, Missing); basal ganglia: 74.1259% (minimum 99%, Missing); bone marrow: 70.1987% (minimum 99%, Missing); cerebellum: 65.8385% (minimum 99%, Missing); cerebral cortex: 69.2810% (minimum 99%, Missing); choroid plexus: 80.3030% (minimum 99%, Missing); colon: 82.8125% (minimum 97%, Missing); duodenum: 87.6033% (minimum 99%, Missing); esophagus: 82.8125% (minimum 97%, Missing); heart muscle: 72.1088% (minimum 99%, Missing); hippocampal formation: 77.3723% (minimum 99%, Missing); hypothalamus: 70.6667% (minimum 99%, Missing); kidney: 75.7143% (minimum 99%, Missing); liver: 76.8116% (minimum 99%, Missing); lung: 81.5385% (minimum 99%, Missing); lymph node: 73.1034% (minimum 97%, Missing); midbrain: 75.1773% (minimum 99%, Missing); pancreas: 85.4839% (minimum 99%, Missing); parathyroid gland: 71.1409% (minimum 97%, Missing); pituitary gland: 76.8116% (minimum 99%, Missing); rectum: 86.1789% (minimum 97%, Missing); retina: 44.3515% (minimum 99%, Missing); salivary gland: 82.8125% (minimum 97%, Missing); skeletal muscle: 71.6216% (minimum 99%, Missing); skin: 77.3723% (minimum 95%, Missing); small intestine: 86.1789% (minimum 99%, Missing); smooth muscle: 76.2590% (minimum 99%, Missing); spinal cord: 74.6479% (minimum 99%, Missing); spleen: 76.2590% (minimum 95%, Missing); stomach: 82.8125% (minimum 97%, Missing); thymus: 67.9487% (minimum 95%, Missing); thyroid gland: 66.2500% (minimum 95%, Missing); tongue: 70.1987% (minimum 97%, Missing); urinary bladder: 83.4646% (minimum 97%, Missing)",-0.2875,-0.268013,-0.546485,0,80,unavailable,13.3,4.5,5.4,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); hypothalamus: 4.4 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); urinary bladder: 2.1 nTPM (protected, limit 2); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196437,ZNF569,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.6027% (minimum 75%, Missing); basal ganglia: 74.1259% (minimum 75%, Missing); bone marrow: 70.1987% (minimum 75%, Missing); cerebellum: 65.8385% (minimum 75%, Missing); cerebral cortex: 69.2810% (minimum 75%, Missing); heart muscle: 72.1088% (minimum 75%, Missing); hypothalamus: 70.6667% (minimum 75%, Missing); retina: 44.3515% (minimum 75%, Missing); skeletal muscle: 71.6216% (minimum 75%, Missing); spinal cord: 74.6479% (minimum 75%, Missing)",0.0125,0.00198675,-0.306485,0,80,unavailable,13.3,4.5,5.4,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); hypothalamus: 4.4 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); urinary bladder: 2.1 nTPM (protected, limit 2); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196437,ZNF569,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.6027% (minimum 75%, Missing); basal ganglia: 74.1259% (minimum 75%, Missing); bone marrow: 70.1987% (minimum 75%, Missing); cerebellum: 65.8385% (minimum 75%, Missing); cerebral cortex: 69.2810% (minimum 75%, Missing); heart muscle: 72.1088% (minimum 75%, Missing); hypothalamus: 70.6667% (minimum 75%, Missing); retina: 44.3515% (minimum 75%, Missing); skeletal muscle: 71.6216% (minimum 75%, Missing); spinal cord: 74.6479% (minimum 75%, Missing)",0.0125,0.00198675,-0.306485,0,80,unavailable,13.3,4.5,5.4,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); bone marrow: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196437,ZNF569,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.6027% (minimum 75%, Missing); basal ganglia: 74.1259% (minimum 75%, Missing); bone marrow: 70.1987% (minimum 75%, Missing); cerebellum: 65.8385% (minimum 75%, Missing); cerebral cortex: 69.2810% (minimum 75%, Missing); heart muscle: 72.1088% (minimum 75%, Missing); hypothalamus: 70.6667% (minimum 75%, Missing); retina: 44.3515% (minimum 75%, Missing); skeletal muscle: 71.6216% (minimum 75%, Missing); spinal cord: 74.6479% (minimum 75%, Missing)",0.0125,0.00198675,-0.306485,0,80,unavailable,13.3,4.5,5.4,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); bone marrow: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196437,ZNF569,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.6027% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.1259% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 70.1987% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.8385% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 69.2810% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 72.1088% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 70.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 44.3515% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 71.6216% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.6479% (minimum 75%, Baseline (adaptation disabled))",0.0125,0.00198675,-0.306485,0,80,unavailable,13.3,4.5,5.4,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); bone marrow: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196437,ZNF569,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.7059% (minimum 95%, Missing); adrenal gland: 91.6667% (minimum 99%, Missing); basal ganglia: 91.6667% (minimum 99%, Missing); bone marrow: 22.9167% (minimum 99%, Missing); cerebral cortex: 91.6667% (minimum 99%, Missing); duodenum: 91.6667% (minimum 99%, Missing); esophagus: 91.6667% (minimum 97%, Missing); heart muscle: 84.6154% (minimum 99%, Missing); hypothalamus: 91.6667% (minimum 99%, Missing); kidney: 91.6667% (minimum 99%, Missing); lung: 91.6667% (minimum 99%, Missing); lymph node: 78.5714% (minimum 97%, Missing); parathyroid gland: 91.6667% (minimum 97%, Missing); pituitary gland: 91.6667% (minimum 99%, Missing); salivary gland: 91.6667% (minimum 97%, Missing); skin: 84.6154% (minimum 95%, Missing); smooth muscle: 91.6667% (minimum 99%, Missing); thymus: 61.1111% (minimum 95%, Missing); thyroid gland: 68.7500% (minimum 95%, Missing)",-0.338889,-0.184286,-0.760833,0,80,unavailable,3.7,0.3,0.7,"bone marrow: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196460,RFX8,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.7059% (minimum 65%, Missing); bone marrow: 22.9167% (minimum 75%, Missing); thymus: 61.1111% (minimum 65%, Missing)",-0.0388889,0.0857143,-0.520833,0,80,unavailable,3.7,0.3,0.7,"bone marrow: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196460,RFX8,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.7059% (minimum 65%, Missing); bone marrow: 22.9167% (minimum 75%, Missing); thymus: 61.1111% (minimum 65%, Missing)",-0.0388889,0.0857143,-0.520833,0,80,unavailable,3.7,0.3,0.7,"bone marrow: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196460,RFX8,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.7059% (minimum 65%, Missing); bone marrow: 22.9167% (minimum 75%, Missing); thymus: 61.1111% (minimum 65%, Missing)",-0.0388889,0.0857143,-0.520833,0,80,unavailable,3.7,0.3,0.7,"bone marrow: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196460,RFX8,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.7059% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 22.9167% (minimum 75%, Baseline (adaptation disabled)); thymus: 61.1111% (minimum 65%, Baseline (adaptation disabled))",-0.0388889,0.0857143,-0.520833,0,80,unavailable,3.7,0.3,0.7,"bone marrow: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196460,RFX8,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.1622% (minimum 95%, Missing); adrenal gland: 62.1622% (minimum 99%, Missing); amygdala: 73.0159% (minimum 99%, Missing); basal ganglia: 71.8750% (minimum 99%, Missing); bone marrow: 75.4098% (minimum 99%, Missing); cerebellum: 70.7692% (minimum 99%, Missing); cerebral cortex: 76.6667% (minimum 99%, Missing); choroid plexus: 79.3103% (minimum 99%, Missing); colon: 64.7887% (minimum 97%, Missing); duodenum: 68.6567% (minimum 99%, Missing); esophagus: 71.8750% (minimum 97%, Missing); heart muscle: 69.6970% (minimum 99%, Missing); hippocampal formation: 70.7692% (minimum 99%, Missing); hypothalamus: 73.0159% (minimum 99%, Missing); kidney: 58.2278% (minimum 99%, Missing); liver: 55.4217% (minimum 99%, Missing); lung: 62.1622% (minimum 99%, Missing); lymph node: 64.7887% (minimum 97%, Missing); midbrain: 70.7692% (minimum 99%, Missing); pancreas: 68.6567% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 82.1429% (minimum 99%, Missing); rectum: 64.7887% (minimum 97%, Missing); retina: 75.4098% (minimum 99%, Missing); salivary gland: 68.6567% (minimum 97%, Missing); skeletal muscle: 71.8750% (minimum 99%, Missing); skin: 66.6667% (minimum 95%, Missing); small intestine: 65.7143% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 70.7692% (minimum 99%, Missing); spleen: 61.3333% (minimum 95%, Missing); stomach: 70.7692% (minimum 97%, Missing); thymus: 59.7403% (minimum 95%, Missing); thyroid gland: 70.7692% (minimum 95%, Missing); tongue: 67.6471% (minimum 97%, Missing); urinary bladder: 63.8889% (minimum 97%, Missing)",-0.352597,-0.331111,-0.435783,0,3,partial,3.7,2.6,3.1,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); lymph node: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); tongue: 2.2 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196466,ZNF799,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.1622% (minimum 65%, Missing); adrenal gland: 62.1622% (minimum 75%, Missing); amygdala: 73.0159% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); cerebellum: 70.7692% (minimum 75%, Missing); colon: 64.7887% (minimum 70%, Missing); duodenum: 68.6567% (minimum 75%, Missing); heart muscle: 69.6970% (minimum 75%, Missing); hippocampal formation: 70.7692% (minimum 75%, Missing); hypothalamus: 73.0159% (minimum 75%, Missing); kidney: 58.2278% (minimum 75%, Missing); liver: 55.4217% (minimum 75%, Missing); lung: 62.1622% (minimum 75%, Missing); lymph node: 64.7887% (minimum 70%, Missing); midbrain: 70.7692% (minimum 75%, Missing); pancreas: 68.6567% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); rectum: 64.7887% (minimum 70%, Missing); salivary gland: 68.6567% (minimum 70%, Missing); skeletal muscle: 71.8750% (minimum 75%, Missing); small intestine: 65.7143% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 70.7692% (minimum 75%, Missing); spleen: 61.3333% (minimum 65%, Missing); thymus: 59.7403% (minimum 65%, Missing); tongue: 67.6471% (minimum 70%, Missing); urinary bladder: 63.8889% (minimum 70%, Missing)",-0.0525974,-0.0611111,-0.195783,0,3,partial,3.7,2.6,3.1,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); lymph node: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); tongue: 2.2 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196466,ZNF799,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.1622% (minimum 65%, Missing); adrenal gland: 62.1622% (minimum 75%, Missing); amygdala: 73.0159% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); cerebellum: 70.7692% (minimum 75%, Missing); colon: 64.7887% (minimum 70%, Missing); duodenum: 68.6567% (minimum 75%, Missing); heart muscle: 69.6970% (minimum 75%, Missing); hippocampal formation: 70.7692% (minimum 75%, Missing); hypothalamus: 73.0159% (minimum 75%, Missing); kidney: 58.2278% (minimum 75%, Missing); liver: 55.4217% (minimum 75%, Missing); lung: 62.1622% (minimum 75%, Missing); lymph node: 64.7887% (minimum 70%, Missing); midbrain: 70.7692% (minimum 75%, Missing); pancreas: 68.6567% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); rectum: 64.7887% (minimum 70%, Missing); salivary gland: 68.6567% (minimum 70%, Missing); skeletal muscle: 71.8750% (minimum 75%, Missing); small intestine: 65.7143% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 70.7692% (minimum 75%, Missing); spleen: 61.3333% (minimum 65%, Missing); thymus: 59.7403% (minimum 65%, Missing); tongue: 67.6471% (minimum 70%, Missing); urinary bladder: 63.8889% (minimum 70%, Missing)",-0.0525974,-0.0611111,-0.195783,0,3,partial,3.7,2.6,3.1,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196466,ZNF799,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.1622% (minimum 65%, Missing); adrenal gland: 62.1622% (minimum 75%, Missing); amygdala: 73.0159% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); cerebellum: 70.7692% (minimum 75%, Missing); colon: 64.7887% (minimum 70%, Missing); duodenum: 68.6567% (minimum 75%, Missing); heart muscle: 69.6970% (minimum 75%, Missing); hippocampal formation: 70.7692% (minimum 75%, Missing); hypothalamus: 73.0159% (minimum 75%, Missing); kidney: 58.2278% (minimum 75%, Missing); liver: 55.4217% (minimum 75%, Missing); lung: 62.1622% (minimum 75%, Missing); lymph node: 64.7887% (minimum 70%, Missing); midbrain: 70.7692% (minimum 75%, Missing); pancreas: 68.6567% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); rectum: 64.7887% (minimum 70%, Missing); salivary gland: 68.6567% (minimum 70%, Missing); skeletal muscle: 71.8750% (minimum 75%, Missing); small intestine: 65.7143% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 70.7692% (minimum 75%, Missing); spleen: 61.3333% (minimum 65%, Missing); thymus: 59.7403% (minimum 65%, Missing); tongue: 67.6471% (minimum 70%, Missing); urinary bladder: 63.8889% (minimum 70%, Missing)",-0.0525974,-0.0611111,-0.195783,0,3,partial,3.7,2.6,3.1,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196466,ZNF799,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.1622% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.1622% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.0159% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.8750% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.7692% (minimum 75%, Baseline (adaptation disabled)); colon: 64.7887% (minimum 70%, Baseline (adaptation disabled)); duodenum: 68.6567% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 69.6970% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.7692% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.0159% (minimum 75%, Baseline (adaptation disabled)); kidney: 58.2278% (minimum 75%, Baseline (adaptation disabled)); liver: 55.4217% (minimum 75%, Baseline (adaptation disabled)); lung: 62.1622% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.7887% (minimum 70%, Baseline (adaptation disabled)); midbrain: 70.7692% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.6567% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); rectum: 64.7887% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 68.6567% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 71.8750% (minimum 75%, Baseline (adaptation disabled)); small intestine: 65.7143% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.7692% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.3333% (minimum 65%, Baseline (adaptation disabled)); thymus: 59.7403% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.6471% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 63.8889% (minimum 70%, Baseline (adaptation disabled))",-0.0525974,-0.0611111,-0.195783,0,3,partial,3.7,2.6,3.1,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196466,ZNF799,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.2652% (minimum 95%, Missing); adrenal gland: 77.9388% (minimum 99%, Missing); amygdala: 78.6992% (minimum 99%, Missing); basal ganglia: 79.6053% (minimum 99%, Missing); bone marrow: 63.5171% (minimum 99%, Missing); cerebellum: 77.1930% (minimum 99%, Missing); cerebral cortex: 75.9812% (minimum 99%, Missing); choroid plexus: 83.5924% (minimum 99%, Missing); colon: 75.7433% (minimum 97%, Missing); duodenum: 75.7433% (minimum 99%, Missing); esophagus: 78.0645% (minimum 97%, Missing); heart muscle: 77.0701% (minimum 99%, Missing); hippocampal formation: 77.4400% (minimum 99%, Missing); hypothalamus: 78.4441% (minimum 99%, Missing); kidney: 77.4400% (minimum 99%, Missing); liver: 68.7500% (minimum 99%, Missing); lung: 73.8931% (minimum 99%, Missing); lymph node: 78.0645% (minimum 97%, Missing); midbrain: 78.5714% (minimum 99%, Missing); pancreas: 77.9388% (minimum 99%, Missing); parathyroid gland: 77.4400% (minimum 97%, Missing); pituitary gland: 82.7350% (minimum 99%, Missing); rectum: 77.4400% (minimum 97%, Missing); retina: 72.3468% (minimum 99%, Missing); salivary gland: 75.6250% (minimum 97%, Missing); skeletal muscle: 69.9422% (minimum 99%, Missing); skin: 69.1429% (minimum 95%, Missing); small intestine: 75.3894% (minimum 99%, Missing); smooth muscle: 77.5641% (minimum 99%, Missing); spinal cord: 76.8254% (minimum 99%, Missing); spleen: 78.6992% (minimum 95%, Missing); stomach: 75.9812% (minimum 97%, Missing); thymus: 77.9388% (minimum 95%, Missing); thyroid gland: 74.0061% (minimum 95%, Missing); tongue: 74.4615% (minimum 97%, Missing); urinary bladder: 77.9388% (minimum 97%, Missing)",-0.267348,-0.225385,-0.354829,0,4,partial,27.8,16.6,22.5,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); liver: 22 nTPM (vital, limit 1); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (manageable, limit 5); tongue: 16.6 nTPM (protected, limit 2); small intestine: 15.8 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 2); colon: 15.5 nTPM (protected, limit 2); duodenum: 15.5 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); stomach: 15.3 nTPM (protected, limit 2); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); kidney: 14.1 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 2); hippocampal formation: 14.1 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.7 nTPM (protected, limit 2); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 2); esophagus: 13.6 nTPM (protected, limit 2); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); spleen: 13.1 nTPM (manageable, limit 5); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196470,SIAH1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.5171% (minimum 75%, Missing); liver: 68.7500% (minimum 75%, Missing); lung: 73.8931% (minimum 75%, Missing); retina: 72.3468% (minimum 75%, Missing); skeletal muscle: 69.9422% (minimum 75%, Missing)",0.0326516,0.0446154,-0.114829,0,4,partial,27.8,16.6,22.5,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); liver: 22 nTPM (vital, limit 1); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (manageable, limit 5); tongue: 16.6 nTPM (protected, limit 2); small intestine: 15.8 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 2); colon: 15.5 nTPM (protected, limit 2); duodenum: 15.5 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); stomach: 15.3 nTPM (protected, limit 2); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); kidney: 14.1 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 2); hippocampal formation: 14.1 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.7 nTPM (protected, limit 2); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 2); esophagus: 13.6 nTPM (protected, limit 2); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); spleen: 13.1 nTPM (manageable, limit 5); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196470,SIAH1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.5171% (minimum 75%, Missing); liver: 68.7500% (minimum 75%, Missing); lung: 73.8931% (minimum 75%, Missing); retina: 72.3468% (minimum 75%, Missing); skeletal muscle: 69.9422% (minimum 75%, Missing)",0.0326516,0.0446154,-0.114829,0,4,partial,27.8,16.6,22.5,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); liver: 22 nTPM (vital, limit 1); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (manageable, limit 5); tongue: 16.6 nTPM (protected, limit 3); small intestine: 15.8 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 3); colon: 15.5 nTPM (protected, limit 3); duodenum: 15.5 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); stomach: 15.3 nTPM (protected, limit 3); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); kidney: 14.1 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 3); hippocampal formation: 14.1 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.7 nTPM (protected, limit 3); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 3); esophagus: 13.6 nTPM (protected, limit 3); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); spleen: 13.1 nTPM (manageable, limit 5); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196470,SIAH1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.5171% (minimum 75%, Missing); liver: 68.7500% (minimum 75%, Missing); lung: 73.8931% (minimum 75%, Missing); retina: 72.3468% (minimum 75%, Missing); skeletal muscle: 69.9422% (minimum 75%, Missing)",0.0326516,0.0446154,-0.114829,0,4,partial,27.8,16.6,22.5,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); liver: 22 nTPM (vital, limit 1); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (manageable, limit 5); tongue: 16.6 nTPM (protected, limit 3); small intestine: 15.8 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 3); colon: 15.5 nTPM (protected, limit 3); duodenum: 15.5 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); stomach: 15.3 nTPM (protected, limit 3); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); kidney: 14.1 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 3); hippocampal formation: 14.1 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.7 nTPM (protected, limit 3); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 3); esophagus: 13.6 nTPM (protected, limit 3); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); spleen: 13.1 nTPM (manageable, limit 5); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196470,SIAH1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.5171% (minimum 75%, Baseline (adaptation disabled)); liver: 68.7500% (minimum 75%, Baseline (adaptation disabled)); lung: 73.8931% (minimum 75%, Baseline (adaptation disabled)); retina: 72.3468% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 69.9422% (minimum 75%, Baseline (adaptation disabled))",0.0326516,0.0446154,-0.114829,0,4,partial,27.8,16.6,22.5,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); liver: 22 nTPM (vital, limit 1); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (manageable, limit 5); tongue: 16.6 nTPM (protected, limit 3); small intestine: 15.8 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 3); colon: 15.5 nTPM (protected, limit 3); duodenum: 15.5 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); stomach: 15.3 nTPM (protected, limit 3); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); kidney: 14.1 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 3); hippocampal formation: 14.1 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.7 nTPM (protected, limit 3); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 3); esophagus: 13.6 nTPM (protected, limit 3); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); spleen: 13.1 nTPM (manageable, limit 5); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196470,SIAH1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196475,GK2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196475,GK2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196475,GK2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196475,GK2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196475,GK2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.3333% (minimum 95%, Missing); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 77.9661% (minimum 99%, Missing); basal ganglia: 77.9661% (minimum 99%, Missing); bone marrow: 36.8000% (minimum 99%, Missing); cerebellum: 76.6667% (minimum 99%, Missing); cerebral cortex: 74.1935% (minimum 99%, Missing); choroid plexus: 69.6970% (minimum 99%, Missing); colon: 56.0976% (minimum 97%, Missing); duodenum: 54.1176% (minimum 99%, Missing); esophagus: 60.5263% (minimum 97%, Missing); heart muscle: 65.7143% (minimum 99%, Missing); hippocampal formation: 77.9661% (minimum 99%, Missing); hypothalamus: 76.6667% (minimum 99%, Missing); kidney: 50.0000% (minimum 99%, Missing); liver: 48.4211% (minimum 98%, Approved); lung: 58.2278% (minimum 99%, Missing); lymph node: 56.7901% (minimum 95%, Approved); midbrain: 76.6667% (minimum 99%, Missing); pancreas: 51.6854% (minimum 99%, Missing); parathyroid gland: 49.4624% (minimum 95%, Approved); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 51.6854% (minimum 97%, Missing); retina: 62.1622% (minimum 99%, Missing); salivary gland: 61.3333% (minimum 97%, Missing); skeletal muscle: 71.8750% (minimum 98%, Approved); skin: 62.1622% (minimum 95%, Missing); small intestine: 50.5495% (minimum 99%, Missing); smooth muscle: 62.1622% (minimum 98%, Approved); spinal cord: 75.4098% (minimum 99%, Missing); spleen: 52.8736% (minimum 90%, Approved); stomach: 52.2727% (minimum 97%, Missing); thymus: 54.1176% (minimum 95%, Missing); thyroid gland: 50.5495% (minimum 95%, Missing); tongue: 69.6970% (minimum 97%, Missing); urinary bladder: 51.6854% (minimum 97%, Missing)",-0.444505,-0.455376,-0.622,0,4,partial,7.9,4.7,4.5,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); pancreas: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); stomach: 4.2 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); salivary gland: 2.9 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196505,GDAP2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.3333% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 36.8000% (minimum 75%, Missing); cerebral cortex: 74.1935% (minimum 75%, Missing); choroid plexus: 69.6970% (minimum 75%, Missing); colon: 56.0976% (minimum 70%, Missing); duodenum: 54.1176% (minimum 75%, Missing); esophagus: 60.5263% (minimum 70%, Missing); heart muscle: 65.7143% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 48.4211% (minimum 70%, Approved); lung: 58.2278% (minimum 75%, Missing); lymph node: 56.7901% (minimum 65%, Approved); pancreas: 51.6854% (minimum 75%, Missing); parathyroid gland: 49.4624% (minimum 65%, Approved); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 51.6854% (minimum 70%, Missing); retina: 62.1622% (minimum 75%, Missing); salivary gland: 61.3333% (minimum 70%, Missing); skin: 62.1622% (minimum 65%, Missing); small intestine: 50.5495% (minimum 75%, Missing); smooth muscle: 62.1622% (minimum 70%, Approved); spleen: 52.8736% (minimum 60%, Approved); stomach: 52.2727% (minimum 70%, Missing); thymus: 54.1176% (minimum 65%, Missing); thyroid gland: 50.5495% (minimum 65%, Missing); tongue: 69.6970% (minimum 70%, Missing); urinary bladder: 51.6854% (minimum 70%, Missing)",-0.144505,-0.183146,-0.382,0,4,partial,7.9,4.7,4.5,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); pancreas: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); stomach: 4.2 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); salivary gland: 2.9 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196505,GDAP2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.3333% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 36.8000% (minimum 75%, Missing); cerebral cortex: 74.1935% (minimum 75%, Missing); choroid plexus: 69.6970% (minimum 75%, Missing); colon: 56.0976% (minimum 70%, Missing); duodenum: 54.1176% (minimum 75%, Missing); esophagus: 60.5263% (minimum 70%, Missing); heart muscle: 65.7143% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 48.4211% (minimum 70%, Approved); lung: 58.2278% (minimum 75%, Missing); lymph node: 56.7901% (minimum 65%, Approved); pancreas: 51.6854% (minimum 75%, Missing); parathyroid gland: 49.4624% (minimum 65%, Approved); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 51.6854% (minimum 70%, Missing); retina: 62.1622% (minimum 75%, Missing); salivary gland: 61.3333% (minimum 70%, Missing); skin: 62.1622% (minimum 65%, Missing); small intestine: 50.5495% (minimum 75%, Missing); smooth muscle: 62.1622% (minimum 70%, Approved); spleen: 52.8736% (minimum 60%, Approved); stomach: 52.2727% (minimum 70%, Missing); thymus: 54.1176% (minimum 65%, Missing); thyroid gland: 50.5495% (minimum 65%, Missing); tongue: 69.6970% (minimum 70%, Missing); urinary bladder: 51.6854% (minimum 70%, Missing)",-0.144505,-0.183146,-0.382,0,4,partial,7.9,4.7,4.5,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); pancreas: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); stomach: 4.2 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196505,GDAP2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.3333% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 36.8000% (minimum 75%, Missing); cerebral cortex: 74.1935% (minimum 75%, Missing); choroid plexus: 69.6970% (minimum 75%, Missing); colon: 56.0976% (minimum 70%, Missing); duodenum: 54.1176% (minimum 75%, Missing); esophagus: 60.5263% (minimum 70%, Missing); heart muscle: 65.7143% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 48.4211% (minimum 70%, Approved); lung: 58.2278% (minimum 75%, Missing); lymph node: 56.7901% (minimum 65%, Approved); pancreas: 51.6854% (minimum 75%, Missing); parathyroid gland: 49.4624% (minimum 65%, Approved); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 51.6854% (minimum 70%, Missing); retina: 62.1622% (minimum 75%, Missing); salivary gland: 61.3333% (minimum 70%, Missing); skin: 62.1622% (minimum 65%, Missing); small intestine: 50.5495% (minimum 75%, Missing); smooth muscle: 62.1622% (minimum 70%, Approved); spleen: 52.8736% (minimum 60%, Approved); stomach: 52.2727% (minimum 70%, Missing); thymus: 54.1176% (minimum 65%, Missing); thyroid gland: 50.5495% (minimum 65%, Missing); tongue: 69.6970% (minimum 70%, Missing); urinary bladder: 51.6854% (minimum 70%, Missing)",-0.144505,-0.183146,-0.382,0,4,partial,7.9,4.7,4.5,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); pancreas: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); stomach: 4.2 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196505,GDAP2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.3333% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 36.8000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.1935% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.6970% (minimum 75%, Baseline (adaptation disabled)); colon: 56.0976% (minimum 70%, Baseline (adaptation disabled)); duodenum: 54.1176% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.5263% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.7143% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 48.4211% (minimum 75%, Baseline (adaptation disabled)); lung: 58.2278% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.7901% (minimum 70%, Baseline (adaptation disabled)); pancreas: 51.6854% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.4624% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); rectum: 51.6854% (minimum 70%, Baseline (adaptation disabled)); retina: 62.1622% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.3333% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 71.8750% (minimum 75%, Baseline (adaptation disabled)); skin: 62.1622% (minimum 65%, Baseline (adaptation disabled)); small intestine: 50.5495% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.1622% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.8736% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.2727% (minimum 70%, Baseline (adaptation disabled)); thymus: 54.1176% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.5495% (minimum 65%, Baseline (adaptation disabled)); tongue: 69.6970% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.6854% (minimum 70%, Baseline (adaptation disabled))",-0.144505,-0.205376,-0.382,0,4,partial,7.9,4.7,4.5,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); rectum: 4.3 nTPM (protected, limit 3); pancreas: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); lymph node: 3.5 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196505,GDAP2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.9451% (minimum 95%, Missing); adrenal gland: 60.2410% (minimum 99%, Missing); amygdala: 69.4444% (minimum 99%, Missing); basal ganglia: 71.4286% (minimum 99%, Missing); bone marrow: 64.9351% (minimum 99%, Missing); cerebellum: 74.6269% (minimum 99%, Missing); cerebral cortex: 60.2410% (minimum 99%, Missing); choroid plexus: 51.5464% (minimum 99%, Missing); colon: 45.0450% (minimum 97%, Missing); duodenum: 26.8817% (minimum 99%, Missing); esophagus: 73.5294% (minimum 97%, Missing); heart muscle: 61.7284% (minimum 99%, Missing); hippocampal formation: 71.4286% (minimum 99%, Missing); hypothalamus: 64.9351% (minimum 99%, Missing); kidney: 56.8182% (minimum 99%, Missing); liver: 54.3478% (minimum 99%, Missing); lung: 50.5051% (minimum 99%, Missing); lymph node: 47.1698% (minimum 97%, Missing); midbrain: 69.4444% (minimum 99%, Missing); pancreas: 72.4638% (minimum 99%, Missing); parathyroid gland: 74.6269% (minimum 97%, Missing); pituitary gland: 78.1250% (minimum 99%, Missing); rectum: 46.2963% (minimum 97%, Missing); retina: 69.4444% (minimum 99%, Missing); salivary gland: 58.8235% (minimum 97%, Missing); skeletal muscle: 75.7576% (minimum 99%, Missing); skin: 79.3651% (minimum 95%, Missing); small intestine: 40.9836% (minimum 99%, Missing); smooth muscle: 59.5238% (minimum 99%, Missing); spinal cord: 67.5676% (minimum 99%, Missing); spleen: 39.3701% (minimum 95%, Missing); stomach: 70.4225% (minimum 97%, Missing); thymus: 64.9351% (minimum 95%, Missing); thyroid gland: 62.5000% (minimum 95%, Missing); tongue: 64.1026% (minimum 97%, Missing); urinary bladder: 56.1798% (minimum 97%, Missing)",-0.556299,-0.51955,-0.721183,0,2,partial,13.6,6.1,7.7,"duodenum: 13.6 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); lymph node: 5.6 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196511,TPK1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.9451% (minimum 65%, Missing); adrenal gland: 60.2410% (minimum 75%, Missing); amygdala: 69.4444% (minimum 75%, Missing); basal ganglia: 71.4286% (minimum 75%, Missing); bone marrow: 64.9351% (minimum 75%, Missing); cerebellum: 74.6269% (minimum 75%, Missing); cerebral cortex: 60.2410% (minimum 75%, Missing); choroid plexus: 51.5464% (minimum 75%, Missing); colon: 45.0450% (minimum 70%, Missing); duodenum: 26.8817% (minimum 75%, Missing); heart muscle: 61.7284% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 64.9351% (minimum 75%, Missing); kidney: 56.8182% (minimum 75%, Missing); liver: 54.3478% (minimum 75%, Missing); lung: 50.5051% (minimum 75%, Missing); lymph node: 47.1698% (minimum 70%, Missing); midbrain: 69.4444% (minimum 75%, Missing); pancreas: 72.4638% (minimum 75%, Missing); rectum: 46.2963% (minimum 70%, Missing); retina: 69.4444% (minimum 75%, Missing); salivary gland: 58.8235% (minimum 70%, Missing); small intestine: 40.9836% (minimum 75%, Missing); smooth muscle: 59.5238% (minimum 75%, Missing); spinal cord: 67.5676% (minimum 75%, Missing); spleen: 39.3701% (minimum 65%, Missing); thymus: 64.9351% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 64.1026% (minimum 70%, Missing); urinary bladder: 56.1798% (minimum 70%, Missing)",-0.256299,-0.24955,-0.481183,0,2,partial,13.6,6.1,7.7,"duodenum: 13.6 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); lymph node: 5.6 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196511,TPK1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.9451% (minimum 65%, Missing); adrenal gland: 60.2410% (minimum 75%, Missing); amygdala: 69.4444% (minimum 75%, Missing); basal ganglia: 71.4286% (minimum 75%, Missing); bone marrow: 64.9351% (minimum 75%, Missing); cerebellum: 74.6269% (minimum 75%, Missing); cerebral cortex: 60.2410% (minimum 75%, Missing); choroid plexus: 51.5464% (minimum 75%, Missing); colon: 45.0450% (minimum 70%, Missing); duodenum: 26.8817% (minimum 75%, Missing); heart muscle: 61.7284% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 64.9351% (minimum 75%, Missing); kidney: 56.8182% (minimum 75%, Missing); liver: 54.3478% (minimum 75%, Missing); lung: 50.5051% (minimum 75%, Missing); lymph node: 47.1698% (minimum 70%, Missing); midbrain: 69.4444% (minimum 75%, Missing); pancreas: 72.4638% (minimum 75%, Missing); rectum: 46.2963% (minimum 70%, Missing); retina: 69.4444% (minimum 75%, Missing); salivary gland: 58.8235% (minimum 70%, Missing); small intestine: 40.9836% (minimum 75%, Missing); smooth muscle: 59.5238% (minimum 75%, Missing); spinal cord: 67.5676% (minimum 75%, Missing); spleen: 39.3701% (minimum 65%, Missing); thymus: 64.9351% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 64.1026% (minimum 70%, Missing); urinary bladder: 56.1798% (minimum 70%, Missing)",-0.256299,-0.24955,-0.481183,0,2,partial,13.6,6.1,7.7,"duodenum: 13.6 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); lymph node: 5.6 nTPM (protected, limit 3); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196511,TPK1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.9451% (minimum 65%, Missing); adrenal gland: 60.2410% (minimum 75%, Missing); amygdala: 69.4444% (minimum 75%, Missing); basal ganglia: 71.4286% (minimum 75%, Missing); bone marrow: 64.9351% (minimum 75%, Missing); cerebellum: 74.6269% (minimum 75%, Missing); cerebral cortex: 60.2410% (minimum 75%, Missing); choroid plexus: 51.5464% (minimum 75%, Missing); colon: 45.0450% (minimum 70%, Missing); duodenum: 26.8817% (minimum 75%, Missing); heart muscle: 61.7284% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 64.9351% (minimum 75%, Missing); kidney: 56.8182% (minimum 75%, Missing); liver: 54.3478% (minimum 75%, Missing); lung: 50.5051% (minimum 75%, Missing); lymph node: 47.1698% (minimum 70%, Missing); midbrain: 69.4444% (minimum 75%, Missing); pancreas: 72.4638% (minimum 75%, Missing); rectum: 46.2963% (minimum 70%, Missing); retina: 69.4444% (minimum 75%, Missing); salivary gland: 58.8235% (minimum 70%, Missing); small intestine: 40.9836% (minimum 75%, Missing); smooth muscle: 59.5238% (minimum 75%, Missing); spinal cord: 67.5676% (minimum 75%, Missing); spleen: 39.3701% (minimum 65%, Missing); thymus: 64.9351% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 64.1026% (minimum 70%, Missing); urinary bladder: 56.1798% (minimum 70%, Missing)",-0.256299,-0.24955,-0.481183,0,2,partial,13.6,6.1,7.7,"duodenum: 13.6 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); lymph node: 5.6 nTPM (protected, limit 3); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196511,TPK1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.9451% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.2410% (minimum 75%, Baseline (adaptation disabled)); amygdala: 69.4444% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.4286% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 64.9351% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.6269% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.2410% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 51.5464% (minimum 75%, Baseline (adaptation disabled)); colon: 45.0450% (minimum 70%, Baseline (adaptation disabled)); duodenum: 26.8817% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 61.7284% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.4286% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.9351% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.8182% (minimum 75%, Baseline (adaptation disabled)); liver: 54.3478% (minimum 75%, Baseline (adaptation disabled)); lung: 50.5051% (minimum 75%, Baseline (adaptation disabled)); lymph node: 47.1698% (minimum 70%, Baseline (adaptation disabled)); midbrain: 69.4444% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.4638% (minimum 75%, Baseline (adaptation disabled)); rectum: 46.2963% (minimum 70%, Baseline (adaptation disabled)); retina: 69.4444% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 58.8235% (minimum 70%, Baseline (adaptation disabled)); small intestine: 40.9836% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 59.5238% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.5676% (minimum 75%, Baseline (adaptation disabled)); spleen: 39.3701% (minimum 65%, Baseline (adaptation disabled)); thymus: 64.9351% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.5000% (minimum 65%, Baseline (adaptation disabled)); tongue: 64.1026% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.1798% (minimum 70%, Baseline (adaptation disabled))",-0.256299,-0.24955,-0.481183,0,2,partial,13.6,6.1,7.7,"duodenum: 13.6 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); lymph node: 5.6 nTPM (protected, limit 3); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196511,TPK1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.8889% (minimum 95%, Missing); adrenal gland: 69.0000% (minimum 99%, Missing); amygdala: 76.6667% (minimum 99%, Missing); basal ganglia: 81.1765% (minimum 99%, Missing); bone marrow: 44.8052% (minimum 99%, Missing); cerebellum: 55.6452% (minimum 99%, Missing); cerebral cortex: 79.3103% (minimum 99%, Missing); choroid plexus: 84.1463% (minimum 99%, Missing); colon: 75.8242% (minimum 97%, Missing); duodenum: 70.4082% (minimum 99%, Missing); esophagus: 73.4043% (minimum 97%, Missing); heart muscle: 86.2500% (minimum 99%, Missing); hippocampal formation: 74.1935% (minimum 99%, Missing); hypothalamus: 79.3103% (minimum 99%, Missing); kidney: 84.1463% (minimum 99%, Missing); liver: 77.5281% (minimum 99%, Missing); lung: 72.6316% (minimum 99%, Missing); lymph node: 39.2045% (minimum 97%, Missing); midbrain: 72.6316% (minimum 99%, Missing); pancreas: 82.1429% (minimum 99%, Missing); parathyroid gland: 82.1429% (minimum 97%, Missing); pituitary gland: 89.6104% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 97.1831% (minimum 99%, Missing); salivary gland: 87.3418% (minimum 97%, Missing); skeletal muscle: 93.2432% (minimum 99%, Missing); skin: 53.9062% (minimum 95%, Missing); small intestine: 70.4082% (minimum 99%, Missing); smooth muscle: 78.4091% (minimum 99%, Missing); spinal cord: 71.8750% (minimum 99%, Missing); spleen: 53.0769% (minimum 95%, Missing); stomach: 81.1765% (minimum 97%, Missing); thymus: 45.0980% (minimum 95%, Missing); thyroid gland: 89.6104% (minimum 95%, Missing); tongue: 87.3418% (minimum 97%, Missing); urinary bladder: 82.1429% (minimum 97%, Missing)",-0.49902,-0.577955,-0.541948,0,80,unavailable,8.5,10.7,8.4,"lymph node: 10.7 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); spleen: 6.1 nTPM (manageable, limit 5); skin: 5.9 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); hippocampal formation: 2.4 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196550,FAM72A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.8889% (minimum 65%, Missing); adrenal gland: 69.0000% (minimum 75%, Missing); bone marrow: 44.8052% (minimum 75%, Missing); cerebellum: 55.6452% (minimum 75%, Missing); duodenum: 70.4082% (minimum 75%, Missing); hippocampal formation: 74.1935% (minimum 75%, Missing); lung: 72.6316% (minimum 75%, Missing); lymph node: 39.2045% (minimum 70%, Missing); midbrain: 72.6316% (minimum 75%, Missing); skin: 53.9062% (minimum 65%, Missing); small intestine: 70.4082% (minimum 75%, Missing); spinal cord: 71.8750% (minimum 75%, Missing); spleen: 53.0769% (minimum 65%, Missing); thymus: 45.0980% (minimum 65%, Missing)",-0.19902,-0.307955,-0.301948,0,80,unavailable,8.5,10.7,8.4,"lymph node: 10.7 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); spleen: 6.1 nTPM (manageable, limit 5); skin: 5.9 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); hippocampal formation: 2.4 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196550,FAM72A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.8889% (minimum 65%, Missing); adrenal gland: 69.0000% (minimum 75%, Missing); bone marrow: 44.8052% (minimum 75%, Missing); cerebellum: 55.6452% (minimum 75%, Missing); duodenum: 70.4082% (minimum 75%, Missing); hippocampal formation: 74.1935% (minimum 75%, Missing); lung: 72.6316% (minimum 75%, Missing); lymph node: 39.2045% (minimum 70%, Missing); midbrain: 72.6316% (minimum 75%, Missing); skin: 53.9062% (minimum 65%, Missing); small intestine: 70.4082% (minimum 75%, Missing); spinal cord: 71.8750% (minimum 75%, Missing); spleen: 53.0769% (minimum 65%, Missing); thymus: 45.0980% (minimum 65%, Missing)",-0.19902,-0.307955,-0.301948,0,80,unavailable,8.5,10.7,8.4,"lymph node: 10.7 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); spleen: 6.1 nTPM (manageable, limit 5); skin: 5.9 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196550,FAM72A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.8889% (minimum 65%, Missing); adrenal gland: 69.0000% (minimum 75%, Missing); bone marrow: 44.8052% (minimum 75%, Missing); cerebellum: 55.6452% (minimum 75%, Missing); duodenum: 70.4082% (minimum 75%, Missing); hippocampal formation: 74.1935% (minimum 75%, Missing); lung: 72.6316% (minimum 75%, Missing); lymph node: 39.2045% (minimum 70%, Missing); midbrain: 72.6316% (minimum 75%, Missing); skin: 53.9062% (minimum 65%, Missing); small intestine: 70.4082% (minimum 75%, Missing); spinal cord: 71.8750% (minimum 75%, Missing); spleen: 53.0769% (minimum 65%, Missing); thymus: 45.0980% (minimum 65%, Missing)",-0.19902,-0.307955,-0.301948,0,80,unavailable,8.5,10.7,8.4,"lymph node: 10.7 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); spleen: 6.1 nTPM (manageable, limit 5); skin: 5.9 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196550,FAM72A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.8889% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 69.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 44.8052% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.6452% (minimum 75%, Baseline (adaptation disabled)); duodenum: 70.4082% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.1935% (minimum 75%, Baseline (adaptation disabled)); lung: 72.6316% (minimum 75%, Baseline (adaptation disabled)); lymph node: 39.2045% (minimum 70%, Baseline (adaptation disabled)); midbrain: 72.6316% (minimum 75%, Baseline (adaptation disabled)); skin: 53.9062% (minimum 65%, Baseline (adaptation disabled)); small intestine: 70.4082% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.8750% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.0769% (minimum 65%, Baseline (adaptation disabled)); thymus: 45.0980% (minimum 65%, Baseline (adaptation disabled))",-0.19902,-0.307955,-0.301948,0,80,unavailable,8.5,10.7,8.4,"lymph node: 10.7 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); spleen: 6.1 nTPM (manageable, limit 5); skin: 5.9 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196550,FAM72A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.1481% (minimum 99%, Missing)",0.05,0.03,-0.00851852,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196553,CCDC196,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · preferential
True,compatible,,True,True,True,,0.35,0.3,0.231481,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196553,CCDC196,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · preferential
True,compatible,,True,True,True,,0.35,0.3,0.231481,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196553,CCDC196,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · preferential
True,compatible,,True,True,True,,0.35,0.3,0.231481,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196553,CCDC196,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · preferential
True,compatible,,True,True,True,,0.35,0.3,0.231481,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196553,CCDC196,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · preferential
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0497689,0.0299498,0.00232181,0,2,partial,77,3.7,26.7,"bone marrow: 77 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 10); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 2); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 2); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 2); skeletal muscle: 4 nTPM (vital, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 2); cerebellum: 2.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196565,HBG2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349769,0.29995,0.242322,0,2,partial,77,3.7,26.7,"bone marrow: 77 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 10); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 2); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 2); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 2); skeletal muscle: 4 nTPM (vital, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 2); cerebellum: 2.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196565,HBG2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349769,0.29995,0.242322,0,2,partial,77,3.7,26.7,"bone marrow: 77 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 10); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 2); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 2); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 2); skeletal muscle: 4 nTPM (vital, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 2); cerebellum: 2.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196565,HBG2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349769,0.29995,0.242322,0,2,partial,77,3.7,26.7,"bone marrow: 77 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 10); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 2); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 2); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 2); skeletal muscle: 4 nTPM (vital, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 2); cerebellum: 2.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196565,HBG2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347324,0.299628,0.242322,0,2,partial,77,3.7,26.7,"bone marrow: 77 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); adipose tissue: 6.6 nTPM (manageable, limit 5); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 3); hypothalamus: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196565,HBG2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 96.5251% (minimum 99%, Missing)",0.05,0.03,-0.024749,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196570,PFN3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.215251,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196570,PFN3,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.215251,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196570,PFN3,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.215251,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196570,PFN3,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.215251,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196570,PFN3,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196578,OR5AC2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196578,OR5AC2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196578,OR5AC2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196578,OR5AC2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196578,OR5AC2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.8421% (minimum 95%, Missing); adrenal gland: 91.6667% (minimum 99%, Missing); bone marrow: 36.6667% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 99%, Missing); choroid plexus: 86.8421% (minimum 99%, Missing); colon: 73.3333% (minimum 97%, Missing); duodenum: 64.7059% (minimum 99%, Missing); esophagus: 73.3333% (minimum 97%, Missing); heart muscle: 71.7391% (minimum 99%, Missing); kidney: 86.8421% (minimum 99%, Missing); liver: 82.5000% (minimum 99%, Missing); lung: 84.6154% (minimum 99%, Missing); lymph node: 51.5625% (minimum 97%, Missing); pancreas: 91.6667% (minimum 99%, Missing); parathyroid gland: 84.6154% (minimum 97%, Missing); rectum: 63.4615% (minimum 97%, Missing); retina: 62.2642% (minimum 99%, Missing); salivary gland: 89.1892% (minimum 97%, Missing); skeletal muscle: 94.2857% (minimum 99%, Missing); skin: 61.1111% (minimum 95%, Missing); small intestine: 67.3469% (minimum 99%, Missing); smooth muscle: 82.5000% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 73.3333% (minimum 97%, Missing); thymus: 46.4789% (minimum 95%, Missing); thyroid gland: 82.5000% (minimum 95%, Missing); tongue: 86.8421% (minimum 97%, Missing); urinary bladder: 86.8421% (minimum 97%, Missing)",-0.485211,-0.454375,-0.623333,0,80,unavailable,5.7,3.1,3.8,"bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196584,XRCC2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.6667% (minimum 75%, Missing); duodenum: 64.7059% (minimum 75%, Missing); heart muscle: 71.7391% (minimum 75%, Missing); lymph node: 51.5625% (minimum 70%, Missing); rectum: 63.4615% (minimum 70%, Missing); retina: 62.2642% (minimum 75%, Missing); skin: 61.1111% (minimum 65%, Missing); small intestine: 67.3469% (minimum 75%, Missing); thymus: 46.4789% (minimum 65%, Missing)",-0.185211,-0.184375,-0.383333,0,80,unavailable,5.7,3.1,3.8,"bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196584,XRCC2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.6667% (minimum 75%, Missing); duodenum: 64.7059% (minimum 75%, Missing); heart muscle: 71.7391% (minimum 75%, Missing); lymph node: 51.5625% (minimum 70%, Missing); rectum: 63.4615% (minimum 70%, Missing); retina: 62.2642% (minimum 75%, Missing); skin: 61.1111% (minimum 65%, Missing); small intestine: 67.3469% (minimum 75%, Missing); thymus: 46.4789% (minimum 65%, Missing)",-0.185211,-0.184375,-0.383333,0,80,unavailable,5.7,3.1,3.8,"bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196584,XRCC2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.6667% (minimum 75%, Missing); duodenum: 64.7059% (minimum 75%, Missing); heart muscle: 71.7391% (minimum 75%, Missing); lymph node: 51.5625% (minimum 70%, Missing); rectum: 63.4615% (minimum 70%, Missing); retina: 62.2642% (minimum 75%, Missing); skin: 61.1111% (minimum 65%, Missing); small intestine: 67.3469% (minimum 75%, Missing); thymus: 46.4789% (minimum 65%, Missing)",-0.185211,-0.184375,-0.383333,0,80,unavailable,5.7,3.1,3.8,"bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196584,XRCC2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.6667% (minimum 75%, Baseline (adaptation disabled)); duodenum: 64.7059% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 71.7391% (minimum 75%, Baseline (adaptation disabled)); lymph node: 51.5625% (minimum 70%, Baseline (adaptation disabled)); rectum: 63.4615% (minimum 70%, Baseline (adaptation disabled)); retina: 62.2642% (minimum 75%, Baseline (adaptation disabled)); skin: 61.1111% (minimum 65%, Baseline (adaptation disabled)); small intestine: 67.3469% (minimum 75%, Baseline (adaptation disabled)); thymus: 46.4789% (minimum 65%, Baseline (adaptation disabled))",-0.185211,-0.184375,-0.383333,0,80,unavailable,5.7,3.1,3.8,"bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196584,XRCC2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 78.9474% (minimum 99%, Missing); amygdala: 84.5070% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 80.0000% (minimum 99%, Missing); cerebellum: 67.4157% (minimum 99%, Missing); cerebral cortex: 68.1818% (minimum 99%, Missing); choroid plexus: 76.9231% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 73.1707% (minimum 99%, Missing); esophagus: 78.9474% (minimum 97%, Missing); heart muscle: 85.7143% (minimum 99%, Missing); hippocampal formation: 84.5070% (minimum 99%, Missing); hypothalamus: 84.5070% (minimum 99%, Missing); kidney: 69.7674% (minimum 99%, Missing); liver: 77.9221% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 68.9655% (minimum 97%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 56.6038% (minimum 99%, Missing); parathyroid gland: 65.9341% (minimum 97%, Missing); pituitary gland: 76.9231% (minimum 99%, Missing); rectum: 68.1818% (minimum 97%, Missing); retina: 40.0000% (minimum 99%, Missing); salivary gland: 73.1707% (minimum 97%, Missing); skeletal muscle: 73.1707% (minimum 99%, Missing); skin: 60.6061% (minimum 95%, Missing); small intestine: 67.4157% (minimum 99%, Missing); smooth muscle: 73.1707% (minimum 99%, Missing); spinal cord: 84.5070% (minimum 99%, Missing); spleen: 73.1707% (minimum 95%, Missing); stomach: 68.9655% (minimum 97%, Missing); thymus: 64.5161% (minimum 95%, Missing); thyroid gland: 64.5161% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 80.0000% (minimum 97%, Missing)",-0.343939,-0.310659,-0.59,0,2,partial,9,3.1,3.9,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); stomach: 2.7 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196597,ZNF782,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 67.4157% (minimum 75%, Missing); cerebral cortex: 68.1818% (minimum 75%, Missing); duodenum: 73.1707% (minimum 75%, Missing); kidney: 69.7674% (minimum 75%, Missing); lymph node: 68.9655% (minimum 70%, Missing); pancreas: 56.6038% (minimum 75%, Missing); parathyroid gland: 65.9341% (minimum 70%, Missing); rectum: 68.1818% (minimum 70%, Missing); retina: 40.0000% (minimum 75%, Missing); skeletal muscle: 73.1707% (minimum 75%, Missing); skin: 60.6061% (minimum 65%, Missing); small intestine: 67.4157% (minimum 75%, Missing); smooth muscle: 73.1707% (minimum 75%, Missing); stomach: 68.9655% (minimum 70%, Missing); thymus: 64.5161% (minimum 65%, Missing); thyroid gland: 64.5161% (minimum 65%, Missing)",-0.0439394,-0.0406593,-0.35,0,2,partial,9,3.1,3.9,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); stomach: 2.7 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196597,ZNF782,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 67.4157% (minimum 75%, Missing); cerebral cortex: 68.1818% (minimum 75%, Missing); duodenum: 73.1707% (minimum 75%, Missing); kidney: 69.7674% (minimum 75%, Missing); lymph node: 68.9655% (minimum 70%, Missing); pancreas: 56.6038% (minimum 75%, Missing); parathyroid gland: 65.9341% (minimum 70%, Missing); rectum: 68.1818% (minimum 70%, Missing); retina: 40.0000% (minimum 75%, Missing); skeletal muscle: 73.1707% (minimum 75%, Missing); skin: 60.6061% (minimum 65%, Missing); small intestine: 67.4157% (minimum 75%, Missing); smooth muscle: 73.1707% (minimum 75%, Missing); stomach: 68.9655% (minimum 70%, Missing); thymus: 64.5161% (minimum 65%, Missing); thyroid gland: 64.5161% (minimum 65%, Missing)",-0.0439394,-0.0406593,-0.35,0,2,partial,9,3.1,3.9,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196597,ZNF782,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 67.4157% (minimum 75%, Missing); cerebral cortex: 68.1818% (minimum 75%, Missing); duodenum: 73.1707% (minimum 75%, Missing); kidney: 69.7674% (minimum 75%, Missing); lymph node: 68.9655% (minimum 70%, Missing); pancreas: 56.6038% (minimum 75%, Missing); parathyroid gland: 65.9341% (minimum 70%, Missing); rectum: 68.1818% (minimum 70%, Missing); retina: 40.0000% (minimum 75%, Missing); skeletal muscle: 73.1707% (minimum 75%, Missing); skin: 60.6061% (minimum 65%, Missing); small intestine: 67.4157% (minimum 75%, Missing); smooth muscle: 73.1707% (minimum 75%, Missing); stomach: 68.9655% (minimum 70%, Missing); thymus: 64.5161% (minimum 65%, Missing); thyroid gland: 64.5161% (minimum 65%, Missing)",-0.0439394,-0.0406593,-0.35,0,2,partial,9,3.1,3.9,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196597,ZNF782,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 67.4157% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.1818% (minimum 75%, Baseline (adaptation disabled)); duodenum: 73.1707% (minimum 75%, Baseline (adaptation disabled)); kidney: 69.7674% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.9655% (minimum 70%, Baseline (adaptation disabled)); pancreas: 56.6038% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.9341% (minimum 70%, Baseline (adaptation disabled)); rectum: 68.1818% (minimum 70%, Baseline (adaptation disabled)); retina: 40.0000% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 73.1707% (minimum 75%, Baseline (adaptation disabled)); skin: 60.6061% (minimum 65%, Baseline (adaptation disabled)); small intestine: 67.4157% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.1707% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.9655% (minimum 70%, Baseline (adaptation disabled)); thymus: 64.5161% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 64.5161% (minimum 65%, Baseline (adaptation disabled))",-0.0439394,-0.0406593,-0.35,0,2,partial,9,3.1,3.9,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196597,ZNF782,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 89.4737% (minimum 99%, Missing)",0.05,0.03,-0.0952632,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196604,POTEF,admission_only,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.144737,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196604,POTEF,selectivity_revised,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.144737,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196604,POTEF,grid_revised,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.144737,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196604,POTEF,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.144737,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196604,POTEF,current_fixed,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3125% (minimum 90%, Approved); adrenal gland: 74.6888% (minimum 98%, Approved); amygdala: 73.1707% (minimum 99%, Missing); basal ganglia: 76.5957% (minimum 99%, Missing); bone marrow: 80.3571% (minimum 99%, Missing); cerebellum: 82.1918% (minimum 98%, Approved); cerebral cortex: 77.5862% (minimum 99%, Missing); choroid plexus: 72.2892% (minimum 99%, Missing); colon: 69.4981% (minimum 97%, Missing); duodenum: 81.4480% (minimum 98%, Approved); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 69.4981% (minimum 99%, Missing); hippocampal formation: 73.1707% (minimum 99%, Missing); hypothalamus: 75.3138% (minimum 99%, Missing); kidney: 78.6026% (minimum 99%, Missing); liver: 80.0000% (minimum 98%, Approved); lung: 73.1707% (minimum 99%, Missing); lymph node: 69.7674% (minimum 95%, Approved); midbrain: 69.7674% (minimum 99%, Missing); pancreas: 82.9493% (minimum 98%, Approved); parathyroid gland: 72.0000% (minimum 95%, Approved); pituitary gland: 76.9231% (minimum 99%, Missing); rectum: 72.5806% (minimum 95%, Approved); retina: 72.8745% (minimum 99%, Missing); salivary gland: 72.2892% (minimum 97%, Missing); skeletal muscle: 78.2609% (minimum 99%, Missing); skin: 71.1462% (minimum 95%, Missing); small intestine: 77.9221% (minimum 99%, Missing); smooth muscle: 64.0569% (minimum 98%, Approved); spinal cord: 65.6934% (minimum 99%, Missing); spleen: 75.3138% (minimum 90%, Approved); stomach: 74.0741% (minimum 97%, Missing); thymus: 71.1462% (minimum 95%, Missing); thyroid gland: 73.1707% (minimum 90%, Approved); tongue: 77.2532% (minimum 97%, Missing); urinary bladder: 58.6319% (minimum 97%, Missing)",-0.238538,-0.383681,-0.339431,0,1,partial,10.1,12.7,7.6,"urinary bladder: 12.7 nTPM (protected, limit 2); smooth muscle: 10.1 nTPM (vital, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); colon: 7.9 nTPM (protected, limit 2); heart muscle: 7.9 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 4); thymus: 7.3 nTPM (manageable, limit 5); skin: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 4); salivary gland: 6.9 nTPM (protected, limit 2); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 4); retina: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 2); adrenal gland: 6.1 nTPM (vital, limit 2); hypothalamus: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 2); cerebellum: 3.9 nTPM (vital, limit 2); pancreas: 3.7 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196605,ZNF846,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 73.1707% (minimum 75%, Missing); choroid plexus: 72.2892% (minimum 75%, Missing); colon: 69.4981% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 69.4981% (minimum 75%, Missing); hippocampal formation: 73.1707% (minimum 75%, Missing); lung: 73.1707% (minimum 75%, Missing); midbrain: 69.7674% (minimum 75%, Missing); retina: 72.8745% (minimum 75%, Missing); smooth muscle: 64.0569% (minimum 70%, Approved); spinal cord: 65.6934% (minimum 75%, Missing); urinary bladder: 58.6319% (minimum 70%, Missing)",0.0614625,-0.113681,-0.0930657,0,1,partial,10.1,12.7,7.6,"urinary bladder: 12.7 nTPM (protected, limit 2); smooth muscle: 10.1 nTPM (vital, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); colon: 7.9 nTPM (protected, limit 2); heart muscle: 7.9 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 4); thymus: 7.3 nTPM (manageable, limit 5); skin: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 4); salivary gland: 6.9 nTPM (protected, limit 2); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 4); retina: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 2); adrenal gland: 6.1 nTPM (vital, limit 2); hypothalamus: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 2); cerebellum: 3.9 nTPM (vital, limit 2); pancreas: 3.7 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196605,ZNF846,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 73.1707% (minimum 75%, Missing); choroid plexus: 72.2892% (minimum 75%, Missing); colon: 69.4981% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 69.4981% (minimum 75%, Missing); hippocampal formation: 73.1707% (minimum 75%, Missing); lung: 73.1707% (minimum 75%, Missing); midbrain: 69.7674% (minimum 75%, Missing); retina: 72.8745% (minimum 75%, Missing); smooth muscle: 64.0569% (minimum 70%, Approved); spinal cord: 65.6934% (minimum 75%, Missing); urinary bladder: 58.6319% (minimum 70%, Missing)",0.0614625,-0.113681,-0.0930657,0,1,partial,10.1,12.7,7.6,"urinary bladder: 12.7 nTPM (protected, limit 3); smooth muscle: 10.1 nTPM (vital, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); colon: 7.9 nTPM (protected, limit 3); heart muscle: 7.9 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 4); thymus: 7.3 nTPM (manageable, limit 5); skin: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 4); salivary gland: 6.9 nTPM (protected, limit 3); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 4); retina: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 3); adrenal gland: 6.1 nTPM (vital, limit 2); hypothalamus: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 2); cerebellum: 3.9 nTPM (vital, limit 2); pancreas: 3.7 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196605,ZNF846,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 73.1707% (minimum 75%, Missing); choroid plexus: 72.2892% (minimum 75%, Missing); colon: 69.4981% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 69.4981% (minimum 75%, Missing); hippocampal formation: 73.1707% (minimum 75%, Missing); lung: 73.1707% (minimum 75%, Missing); midbrain: 69.7674% (minimum 75%, Missing); retina: 72.8745% (minimum 75%, Missing); smooth muscle: 64.0569% (minimum 70%, Approved); spinal cord: 65.6934% (minimum 75%, Missing); urinary bladder: 58.6319% (minimum 70%, Missing)",0.0614625,-0.113681,-0.0930657,0,1,partial,10.1,12.7,7.6,"urinary bladder: 12.7 nTPM (protected, limit 3); smooth muscle: 10.1 nTPM (vital, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); colon: 7.9 nTPM (protected, limit 3); heart muscle: 7.9 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 4); thymus: 7.3 nTPM (manageable, limit 5); skin: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 4); salivary gland: 6.9 nTPM (protected, limit 3); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 4); retina: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 3); adrenal gland: 6.1 nTPM (vital, limit 2); hypothalamus: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 2); cerebellum: 3.9 nTPM (vital, limit 2); pancreas: 3.7 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196605,ZNF846,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.6888% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.1707% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.2892% (minimum 75%, Baseline (adaptation disabled)); colon: 69.4981% (minimum 70%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.4981% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.1707% (minimum 75%, Baseline (adaptation disabled)); lung: 73.1707% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.7674% (minimum 70%, Baseline (adaptation disabled)); midbrain: 69.7674% (minimum 75%, Baseline (adaptation disabled)); retina: 72.8745% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.0569% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.6934% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 58.6319% (minimum 70%, Baseline (adaptation disabled))",0.053125,-0.113681,-0.109431,0,1,partial,10.1,12.7,7.6,"urinary bladder: 12.7 nTPM (protected, limit 3); smooth muscle: 10.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); colon: 7.9 nTPM (protected, limit 3); heart muscle: 7.9 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 3); midbrain: 7.8 nTPM (vital, limit 1); adipose tissue: 7.6 nTPM (manageable, limit 5); thymus: 7.3 nTPM (manageable, limit 5); skin: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 3); salivary gland: 6.9 nTPM (protected, limit 3); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 3); retina: 6.7 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); hippocampal formation: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 3); adrenal gland: 6.1 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196605,ZNF846,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 82.7338% (minimum 98%, Approved); amygdala: 91.2698% (minimum 99%, Missing); basal ganglia: 91.2698% (minimum 99%, Missing); cerebellum: 93.4959% (minimum 98%, Approved); cerebral cortex: 89.1473% (minimum 98%, Approved); choroid plexus: 95.0413% (minimum 99%, Missing); heart muscle: 94.2623% (minimum 98%, Approved); hippocampal formation: 92.7419% (minimum 99%, Missing); hypothalamus: 87.7863% (minimum 99%, Missing); kidney: 92.7419% (minimum 98%, Approved); liver: 76.6667% (minimum 98%, Approved); lung: 97.4576% (minimum 98%, Approved); midbrain: 92.0000% (minimum 99%, Missing); pancreas: 97.4576% (minimum 98%, Approved); parathyroid gland: 92.7419% (minimum 95%, Approved); pituitary gland: 82.7338% (minimum 99%, Missing); retina: 78.2313% (minimum 99%, Missing); smooth muscle: 95.8333% (minimum 98%, Approved); spinal cord: 94.2623% (minimum 99%, Missing)",0.0413793,-0.0225806,-0.213333,0,1,partial,3.5,0.9,0.6,"liver: 3.5 nTPM (vital, limit 2); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196632,WNK3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341379,0.274576,0.0323129,0,1,partial,3.5,0.9,0.6,"liver: 3.5 nTPM (vital, limit 2); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196632,WNK3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341379,0.274576,0.0323129,0,1,partial,3.5,0.9,0.6,"liver: 3.5 nTPM (vital, limit 2); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196632,WNK3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341379,0.274576,0.0323129,0,1,partial,3.5,0.9,0.6,"liver: 3.5 nTPM (vital, limit 2); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196632,WNK3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.300413,0.227419,0.0166667,0,1,partial,3.5,0.9,0.6,"liver: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196632,WNK3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 86.9565% (minimum 97%, Supported); amygdala: 88.4956% (minimum 99%, Missing); basal ganglia: 85.4701% (minimum 99%, Missing); bone marrow: 92.5926% (minimum 97%, Supported); cerebellum: 95.2381% (minimum 97%, Supported); cerebral cortex: 83.3333% (minimum 97%, Supported); choroid plexus: 71.4286% (minimum 99%, Missing); colon: 75.7576% (minimum 97%, Missing); duodenum: 80.0000% (minimum 99%, Missing); esophagus: 84.0336% (minimum 90%, Supported); heart muscle: 86.2069% (minimum 97%, Supported); hippocampal formation: 88.4956% (minimum 99%, Missing); hypothalamus: 88.4956% (minimum 99%, Missing); kidney: 68.0272% (minimum 97%, Supported); liver: 80.6452% (minimum 97%, Supported); lung: 76.3359% (minimum 97%, Supported); lymph node: 82.6446% (minimum 90%, Supported); midbrain: 90.0901% (minimum 99%, Missing); pancreas: 81.3008% (minimum 97%, Supported); parathyroid gland: 67.1141% (minimum 90%, Supported); pituitary gland: 86.2069% (minimum 99%, Missing); rectum: 77.5194% (minimum 97%, Missing); retina: 66.2252% (minimum 99%, Missing); salivary gland: 74.0741% (minimum 90%, Supported); skeletal muscle: 96.1538% (minimum 97%, Supported); small intestine: 78.1250% (minimum 99%, Missing); smooth muscle: 80.6452% (minimum 97%, Supported); spinal cord: 89.2857% (minimum 99%, Missing); stomach: 72.4638% (minimum 90%, Supported); thymus: 75.7576% (minimum 95%, Missing); thyroid gland: 55.8659% (minimum 80%, Supported); tongue: 96.1538% (minimum 97%, Missing); urinary bladder: 84.7458% (minimum 90%, Supported)",-0.241341,-0.228859,-0.327748,0,8,partial,5.1,4.9,7.9,"retina: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 3); choroid plexus: 4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 3); rectum: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196659,IFT70B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 71.4286% (minimum 75%, Missing); retina: 66.2252% (minimum 75%, Missing)",0.00865922,0.0575758,-0.0877483,0,8,partial,5.1,4.9,7.9,"retina: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 3); choroid plexus: 4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 3); rectum: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196659,IFT70B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 71.4286% (minimum 75%, Missing); retina: 66.2252% (minimum 75%, Missing)",0.00865922,0.0575758,-0.0877483,0,8,partial,5.1,4.9,7.9,"retina: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 3); choroid plexus: 4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196659,IFT70B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 71.4286% (minimum 75%, Missing); retina: 66.2252% (minimum 75%, Missing)",0.00865922,0.0575758,-0.0877483,0,8,partial,5.1,4.9,7.9,"retina: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 3); choroid plexus: 4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196659,IFT70B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 71.4286% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.0272% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 67.1141% (minimum 70%, Baseline (adaptation disabled)); retina: 66.2252% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 55.8659% (minimum 65%, Baseline (adaptation disabled))",-0.0913408,-0.0288591,-0.0877483,0,8,partial,5.1,4.9,7.9,"thyroid gland: 7.9 nTPM (manageable, limit 5); retina: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.9 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); salivary gland: 3.5 nTPM (protected, limit 3); colon: 3.2 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196659,IFT70B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.4615% (minimum 95%, Missing); adrenal gland: 67.3469% (minimum 99%, Missing); amygdala: 61.4907% (minimum 99%, Missing); basal ganglia: 61.4907% (minimum 99%, Missing); bone marrow: 90.8257% (minimum 99%, Missing); cerebellum: 43.2314% (minimum 99%, Missing); cerebral cortex: 60.7362% (minimum 99%, Missing); choroid plexus: 87.6106% (minimum 99%, Missing); colon: 64.2857% (minimum 97%, Missing); duodenum: 58.2353% (minimum 99%, Missing); esophagus: 75.5725% (minimum 97%, Missing); heart muscle: 57.5581% (minimum 99%, Missing); hippocampal formation: 58.9286% (minimum 99%, Missing); hypothalamus: 61.8750% (minimum 99%, Missing); kidney: 55.6180% (minimum 99%, Missing); liver: 29.2035% (minimum 99%, Missing); lung: 76.1538% (minimum 99%, Missing); lymph node: 81.1475% (minimum 97%, Missing); midbrain: 58.9286% (minimum 99%, Missing); pancreas: 56.5714% (minimum 99%, Missing); parathyroid gland: 90.0000% (minimum 97%, Missing); pituitary gland: 63.4615% (minimum 99%, Missing); rectum: 81.1475% (minimum 97%, Missing); retina: 44.1964% (minimum 99%, Missing); salivary gland: 70.2128% (minimum 97%, Missing); skeletal muscle: 61.1111% (minimum 99%, Missing); skin: 65.1316% (minimum 95%, Missing); small intestine: 54.0984% (minimum 99%, Missing); smooth muscle: 86.0870% (minimum 99%, Missing); spinal cord: 59.6386% (minimum 99%, Missing); spleen: 70.2128% (minimum 95%, Missing); stomach: 63.4615% (minimum 97%, Missing); thymus: 83.8983% (minimum 95%, Missing); thyroid gland: 68.7500% (minimum 95%, Missing); tongue: 86.0870% (minimum 97%, Missing); urinary bladder: 67.3469% (minimum 97%, Missing)",-0.315385,-0.335385,-0.697965,0,80,unavailable,24,5.7,5.7,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 2); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); colon: 5.5 nTPM (protected, limit 2); skin: 5.3 nTPM (manageable, limit 5); urinary bladder: 4.8 nTPM (protected, limit 2); adrenal gland: 4.8 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196689,TRPV1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.4615% (minimum 65%, Missing); adrenal gland: 67.3469% (minimum 75%, Missing); amygdala: 61.4907% (minimum 75%, Missing); basal ganglia: 61.4907% (minimum 75%, Missing); cerebellum: 43.2314% (minimum 75%, Missing); cerebral cortex: 60.7362% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 58.2353% (minimum 75%, Missing); heart muscle: 57.5581% (minimum 75%, Missing); hippocampal formation: 58.9286% (minimum 75%, Missing); hypothalamus: 61.8750% (minimum 75%, Missing); kidney: 55.6180% (minimum 75%, Missing); liver: 29.2035% (minimum 75%, Missing); midbrain: 58.9286% (minimum 75%, Missing); pancreas: 56.5714% (minimum 75%, Missing); pituitary gland: 63.4615% (minimum 75%, Missing); retina: 44.1964% (minimum 75%, Missing); skeletal muscle: 61.1111% (minimum 75%, Missing); small intestine: 54.0984% (minimum 75%, Missing); spinal cord: 59.6386% (minimum 75%, Missing); stomach: 63.4615% (minimum 70%, Missing); urinary bladder: 67.3469% (minimum 70%, Missing)",-0.0153846,-0.0653846,-0.457965,0,80,unavailable,24,5.7,5.7,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 2); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); colon: 5.5 nTPM (protected, limit 2); skin: 5.3 nTPM (manageable, limit 5); urinary bladder: 4.8 nTPM (protected, limit 2); adrenal gland: 4.8 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196689,TRPV1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.4615% (minimum 65%, Missing); adrenal gland: 67.3469% (minimum 75%, Missing); amygdala: 61.4907% (minimum 75%, Missing); basal ganglia: 61.4907% (minimum 75%, Missing); cerebellum: 43.2314% (minimum 75%, Missing); cerebral cortex: 60.7362% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 58.2353% (minimum 75%, Missing); heart muscle: 57.5581% (minimum 75%, Missing); hippocampal formation: 58.9286% (minimum 75%, Missing); hypothalamus: 61.8750% (minimum 75%, Missing); kidney: 55.6180% (minimum 75%, Missing); liver: 29.2035% (minimum 75%, Missing); midbrain: 58.9286% (minimum 75%, Missing); pancreas: 56.5714% (minimum 75%, Missing); pituitary gland: 63.4615% (minimum 75%, Missing); retina: 44.1964% (minimum 75%, Missing); skeletal muscle: 61.1111% (minimum 75%, Missing); small intestine: 54.0984% (minimum 75%, Missing); spinal cord: 59.6386% (minimum 75%, Missing); stomach: 63.4615% (minimum 70%, Missing); urinary bladder: 67.3469% (minimum 70%, Missing)",-0.0153846,-0.0653846,-0.457965,0,80,unavailable,24,5.7,5.7,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 3); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); colon: 5.5 nTPM (protected, limit 3); skin: 5.3 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); salivary gland: 4.2 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196689,TRPV1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.4615% (minimum 65%, Missing); adrenal gland: 67.3469% (minimum 75%, Missing); amygdala: 61.4907% (minimum 75%, Missing); basal ganglia: 61.4907% (minimum 75%, Missing); cerebellum: 43.2314% (minimum 75%, Missing); cerebral cortex: 60.7362% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 58.2353% (minimum 75%, Missing); heart muscle: 57.5581% (minimum 75%, Missing); hippocampal formation: 58.9286% (minimum 75%, Missing); hypothalamus: 61.8750% (minimum 75%, Missing); kidney: 55.6180% (minimum 75%, Missing); liver: 29.2035% (minimum 75%, Missing); midbrain: 58.9286% (minimum 75%, Missing); pancreas: 56.5714% (minimum 75%, Missing); pituitary gland: 63.4615% (minimum 75%, Missing); retina: 44.1964% (minimum 75%, Missing); skeletal muscle: 61.1111% (minimum 75%, Missing); small intestine: 54.0984% (minimum 75%, Missing); spinal cord: 59.6386% (minimum 75%, Missing); stomach: 63.4615% (minimum 70%, Missing); urinary bladder: 67.3469% (minimum 70%, Missing)",-0.0153846,-0.0653846,-0.457965,0,80,unavailable,24,5.7,5.7,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 3); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); colon: 5.5 nTPM (protected, limit 3); skin: 5.3 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); salivary gland: 4.2 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196689,TRPV1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.4615% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 67.3469% (minimum 75%, Baseline (adaptation disabled)); amygdala: 61.4907% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.4907% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.2314% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.7362% (minimum 75%, Baseline (adaptation disabled)); colon: 64.2857% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.2353% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 57.5581% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.9286% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.8750% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.6180% (minimum 75%, Baseline (adaptation disabled)); liver: 29.2035% (minimum 75%, Baseline (adaptation disabled)); midbrain: 58.9286% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.5714% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 63.4615% (minimum 75%, Baseline (adaptation disabled)); retina: 44.1964% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 61.1111% (minimum 75%, Baseline (adaptation disabled)); small intestine: 54.0984% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.6386% (minimum 75%, Baseline (adaptation disabled)); stomach: 63.4615% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.3469% (minimum 70%, Baseline (adaptation disabled))",-0.0153846,-0.0653846,-0.457965,0,80,unavailable,24,5.7,5.7,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 3); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); colon: 5.5 nTPM (protected, limit 3); skin: 5.3 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); salivary gland: 4.2 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196689,TRPV1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.8099% (minimum 95%, Uncertain); adrenal gland: 57.7947% (minimum 99%, Missing); amygdala: 61.7886% (minimum 99%, Missing); basal ganglia: 61.2903% (minimum 99%, Missing); bone marrow: 81.2834% (minimum 99%, Missing); cerebellum: 54.8736% (minimum 99%, Missing); cerebral cortex: 44.3149% (minimum 99%, Missing); choroid plexus: 61.5385% (minimum 99%, Missing); colon: 60.5578% (minimum 97%, Missing); duodenum: 65.5172% (minimum 99%, Missing); esophagus: 70.3704% (minimum 97%, Missing); heart muscle: 54.8736% (minimum 99%, Missing); hippocampal formation: 61.7886% (minimum 99%, Missing); hypothalamus: 62.2951% (minimum 99%, Missing); kidney: 52.5952% (minimum 99%, Missing); liver: 55.8824% (minimum 99%, Missing); lung: 65.2361% (minimum 99%, Missing); lymph node: 61.2903% (minimum 97%, Missing); midbrain: 62.0408% (minimum 99%, Missing); pancreas: 58.4615% (minimum 99%, Missing); parathyroid gland: 45.3731% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 60.0791% (minimum 97%, Missing); retina: 36.8039% (minimum 99%, Missing); salivary gland: 57.3585% (minimum 97%, Missing); skeletal muscle: 62.2951% (minimum 99%, Missing); skin: 58.2375% (minimum 95%, Missing); small intestine: 63.5983% (minimum 99%, Missing); smooth muscle: 61.0442% (minimum 99%, Missing); spinal cord: 58.9147% (minimum 99%, Missing); spleen: 64.1350% (minimum 95%, Missing); stomach: 62.5514% (minimum 97%, Missing); thymus: 47.7987% (minimum 95%, Missing); thyroid gland: 42.9379% (minimum 95%, Missing); tongue: 55.2727% (minimum 97%, Missing); urinary bladder: 56.7164% (minimum 97%, Missing)",-0.520621,-0.516269,-0.621961,0,6,partial,26.1,18.3,20.2,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (manageable, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 2); thymus: 16.6 nTPM (manageable, limit 5); kidney: 13.7 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 2); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 2); salivary gland: 11.3 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 2); colon: 9.9 nTPM (protected, limit 2); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 2); choroid plexus: 9.5 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); small intestine: 8.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196712,NF1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.8099% (minimum 65%, Uncertain); adrenal gland: 57.7947% (minimum 75%, Missing); amygdala: 61.7886% (minimum 75%, Missing); basal ganglia: 61.2903% (minimum 75%, Missing); cerebellum: 54.8736% (minimum 75%, Missing); cerebral cortex: 44.3149% (minimum 75%, Missing); choroid plexus: 61.5385% (minimum 75%, Missing); colon: 60.5578% (minimum 70%, Missing); duodenum: 65.5172% (minimum 75%, Missing); heart muscle: 54.8736% (minimum 75%, Missing); hippocampal formation: 61.7886% (minimum 75%, Missing); hypothalamus: 62.2951% (minimum 75%, Missing); kidney: 52.5952% (minimum 75%, Missing); liver: 55.8824% (minimum 75%, Missing); lung: 65.2361% (minimum 75%, Missing); lymph node: 61.2903% (minimum 70%, Missing); midbrain: 62.0408% (minimum 75%, Missing); pancreas: 58.4615% (minimum 75%, Missing); parathyroid gland: 45.3731% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 60.0791% (minimum 70%, Missing); retina: 36.8039% (minimum 75%, Missing); salivary gland: 57.3585% (minimum 70%, Missing); skeletal muscle: 62.2951% (minimum 75%, Missing); skin: 58.2375% (minimum 65%, Missing); small intestine: 63.5983% (minimum 75%, Missing); smooth muscle: 61.0442% (minimum 75%, Missing); spinal cord: 58.9147% (minimum 75%, Missing); spleen: 64.1350% (minimum 65%, Missing); stomach: 62.5514% (minimum 70%, Missing); thymus: 47.7987% (minimum 65%, Missing); thyroid gland: 42.9379% (minimum 65%, Missing); tongue: 55.2727% (minimum 70%, Missing); urinary bladder: 56.7164% (minimum 70%, Missing)",-0.220621,-0.246269,-0.381961,0,6,partial,26.1,18.3,20.2,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (manageable, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 2); thymus: 16.6 nTPM (manageable, limit 5); kidney: 13.7 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 2); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 2); salivary gland: 11.3 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 2); colon: 9.9 nTPM (protected, limit 2); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 2); choroid plexus: 9.5 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); small intestine: 8.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196712,NF1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.8099% (minimum 65%, Uncertain); adrenal gland: 57.7947% (minimum 75%, Missing); amygdala: 61.7886% (minimum 75%, Missing); basal ganglia: 61.2903% (minimum 75%, Missing); cerebellum: 54.8736% (minimum 75%, Missing); cerebral cortex: 44.3149% (minimum 75%, Missing); choroid plexus: 61.5385% (minimum 75%, Missing); colon: 60.5578% (minimum 70%, Missing); duodenum: 65.5172% (minimum 75%, Missing); heart muscle: 54.8736% (minimum 75%, Missing); hippocampal formation: 61.7886% (minimum 75%, Missing); hypothalamus: 62.2951% (minimum 75%, Missing); kidney: 52.5952% (minimum 75%, Missing); liver: 55.8824% (minimum 75%, Missing); lung: 65.2361% (minimum 75%, Missing); lymph node: 61.2903% (minimum 70%, Missing); midbrain: 62.0408% (minimum 75%, Missing); pancreas: 58.4615% (minimum 75%, Missing); parathyroid gland: 45.3731% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 60.0791% (minimum 70%, Missing); retina: 36.8039% (minimum 75%, Missing); salivary gland: 57.3585% (minimum 70%, Missing); skeletal muscle: 62.2951% (minimum 75%, Missing); skin: 58.2375% (minimum 65%, Missing); small intestine: 63.5983% (minimum 75%, Missing); smooth muscle: 61.0442% (minimum 75%, Missing); spinal cord: 58.9147% (minimum 75%, Missing); spleen: 64.1350% (minimum 65%, Missing); stomach: 62.5514% (minimum 70%, Missing); thymus: 47.7987% (minimum 65%, Missing); thyroid gland: 42.9379% (minimum 65%, Missing); tongue: 55.2727% (minimum 70%, Missing); urinary bladder: 56.7164% (minimum 70%, Missing)",-0.220621,-0.246269,-0.381961,0,6,partial,26.1,18.3,20.2,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (manageable, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 3); thymus: 16.6 nTPM (manageable, limit 5); kidney: 13.7 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 3); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 3); salivary gland: 11.3 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 3); colon: 9.9 nTPM (protected, limit 3); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 3); choroid plexus: 9.5 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); small intestine: 8.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 3); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196712,NF1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.8099% (minimum 65%, Uncertain); adrenal gland: 57.7947% (minimum 75%, Missing); amygdala: 61.7886% (minimum 75%, Missing); basal ganglia: 61.2903% (minimum 75%, Missing); cerebellum: 54.8736% (minimum 75%, Missing); cerebral cortex: 44.3149% (minimum 75%, Missing); choroid plexus: 61.5385% (minimum 75%, Missing); colon: 60.5578% (minimum 70%, Missing); duodenum: 65.5172% (minimum 75%, Missing); heart muscle: 54.8736% (minimum 75%, Missing); hippocampal formation: 61.7886% (minimum 75%, Missing); hypothalamus: 62.2951% (minimum 75%, Missing); kidney: 52.5952% (minimum 75%, Missing); liver: 55.8824% (minimum 75%, Missing); lung: 65.2361% (minimum 75%, Missing); lymph node: 61.2903% (minimum 70%, Missing); midbrain: 62.0408% (minimum 75%, Missing); pancreas: 58.4615% (minimum 75%, Missing); parathyroid gland: 45.3731% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 60.0791% (minimum 70%, Missing); retina: 36.8039% (minimum 75%, Missing); salivary gland: 57.3585% (minimum 70%, Missing); skeletal muscle: 62.2951% (minimum 75%, Missing); skin: 58.2375% (minimum 65%, Missing); small intestine: 63.5983% (minimum 75%, Missing); smooth muscle: 61.0442% (minimum 75%, Missing); spinal cord: 58.9147% (minimum 75%, Missing); spleen: 64.1350% (minimum 65%, Missing); stomach: 62.5514% (minimum 70%, Missing); thymus: 47.7987% (minimum 65%, Missing); thyroid gland: 42.9379% (minimum 65%, Missing); tongue: 55.2727% (minimum 70%, Missing); urinary bladder: 56.7164% (minimum 70%, Missing)",-0.220621,-0.246269,-0.381961,0,6,partial,26.1,18.3,20.2,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (manageable, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 3); thymus: 16.6 nTPM (manageable, limit 5); kidney: 13.7 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 3); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 3); salivary gland: 11.3 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 3); colon: 9.9 nTPM (protected, limit 3); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 3); choroid plexus: 9.5 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); small intestine: 8.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 3); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196712,NF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.8099% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 57.7947% (minimum 75%, Baseline (adaptation disabled)); amygdala: 61.7886% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.2903% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.8736% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 44.3149% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 61.5385% (minimum 75%, Baseline (adaptation disabled)); colon: 60.5578% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.5172% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 54.8736% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.7886% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.2951% (minimum 75%, Baseline (adaptation disabled)); kidney: 52.5952% (minimum 75%, Baseline (adaptation disabled)); liver: 55.8824% (minimum 75%, Baseline (adaptation disabled)); lung: 65.2361% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.2903% (minimum 70%, Baseline (adaptation disabled)); midbrain: 62.0408% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.4615% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 45.3731% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.0791% (minimum 70%, Baseline (adaptation disabled)); retina: 36.8039% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 57.3585% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 62.2951% (minimum 75%, Baseline (adaptation disabled)); skin: 58.2375% (minimum 65%, Baseline (adaptation disabled)); small intestine: 63.5983% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.0442% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 58.9147% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.1350% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.5514% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.7987% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 42.9379% (minimum 65%, Baseline (adaptation disabled)); tongue: 55.2727% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 56.7164% (minimum 70%, Baseline (adaptation disabled))",-0.220621,-0.246269,-0.381961,0,6,partial,26.1,18.3,20.2,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (manageable, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 3); thymus: 16.6 nTPM (manageable, limit 5); kidney: 13.7 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 3); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 3); salivary gland: 11.3 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 3); colon: 9.9 nTPM (protected, limit 3); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 3); choroid plexus: 9.5 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); small intestine: 8.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 3); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196712,NF1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0498071,0.0269231,0.00922899,0,3,partial,5,1.6,0.2,"pancreas: 5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196748,CLPSL2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349807,0.296923,0.249229,0,3,partial,5,1.6,0.2,"pancreas: 5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196748,CLPSL2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349807,0.296923,0.249229,0,3,partial,5,1.6,0.2,"pancreas: 5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196748,CLPSL2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349807,0.296923,0.249229,0,3,partial,5,1.6,0.2,"pancreas: 5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196748,CLPSL2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349614,0.296923,0.240447,0,3,partial,5,1.6,0.2,"pancreas: 5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196748,CLPSL2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 99%, Missing)",0.05,0.03,-0.49,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196772,OR14A16,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196772,OR14A16,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196772,OR14A16,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196772,OR14A16,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196772,OR14A16,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196832,OR11G2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196832,OR11G2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196832,OR11G2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196832,OR11G2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000196832,OR11G2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 88.8889% (minimum 99%, Missing); pancreas: 96.9697% (minimum 99%, Missing); pituitary gland: 96.9697% (minimum 99%, Missing); retina: 96.9697% (minimum 99%, Missing); stomach: 94.1176% (minimum 97%, Missing)",0.019697,-0.0288235,-0.101111,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196834,POTEI,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.319697,0.241176,0.138889,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196834,POTEI,selectivity_revised,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.319697,0.241176,0.138889,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196834,POTEI,grid_revised,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.319697,0.241176,0.138889,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196834,POTEI,current_adaptive,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.319697,0.241176,0.138889,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196834,POTEI,current_fixed,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.05,0.03,0.00909112,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196844,PATE2,admission_only,True,False,True,True,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.249091,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196844,PATE2,selectivity_revised,True,False,True,True,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.249091,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196844,PATE2,grid_revised,True,False,True,True,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.249091,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196844,PATE2,current_adaptive,True,False,True,True,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.249091,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196844,PATE2,current_fixed,True,False,True,True,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 97.2477% (minimum 99%, Missing); retina: 96.3636% (minimum 99%, Missing); small intestine: 97.2477% (minimum 99%, Missing)",0.05,0.03,-0.0263636,0,4,partial,0.4,0.5,0.5,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196860,TOMM20L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.213636,0,4,partial,0.4,0.5,0.5,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196860,TOMM20L,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.213636,0,4,partial,0.4,0.5,0.5,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196860,TOMM20L,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.213636,0,4,partial,0.4,0.5,0.5,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196860,TOMM20L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.304955,0.254955,0.213636,0,4,partial,0.4,0.5,0.5,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196860,TOMM20L,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.7368% (minimum 99%, Missing); bone marrow: 97.2973% (minimum 99%, Missing); cerebral cortex: 94.7368% (minimum 99%, Missing); choroid plexus: 94.7368% (minimum 99%, Missing); duodenum: 94.7368% (minimum 99%, Missing); kidney: 97.2973% (minimum 99%, Missing); liver: 97.2973% (minimum 99%, Missing); lung: 97.2973% (minimum 99%, Missing); lymph node: 94.7368% (minimum 97%, Missing); retina: 78.2609% (minimum 99%, Missing); skeletal muscle: 94.7368% (minimum 99%, Missing); small intestine: 94.7368% (minimum 99%, Missing); spleen: 94.7368% (minimum 95%, Missing); stomach: 92.3077% (minimum 97%, Missing); thymus: 92.3077% (minimum 95%, Missing)",-0.0269231,-0.0469231,-0.207391,0,80,unavailable,1,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196862,RGPD4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.273077,0.223077,0.0326087,0,80,unavailable,1,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196862,RGPD4,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.273077,0.223077,0.0326087,0,80,unavailable,1,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196862,RGPD4,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.273077,0.223077,0.0326087,0,80,unavailable,1,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196862,RGPD4,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.273077,0.223077,0.0326087,0,80,unavailable,1,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196862,RGPD4,current_fixed,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.00424893,0.00126638,0,80,unavailable,0.2,0.6,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196900,SPMIP10,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.274249,0.241266,0,80,unavailable,0.2,0.6,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196900,SPMIP10,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.274249,0.241266,0,80,unavailable,0.2,0.6,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196900,SPMIP10,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.274249,0.241266,0,80,unavailable,0.2,0.6,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196900,SPMIP10,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.274249,0.241266,0,80,unavailable,0.2,0.6,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196900,SPMIP10,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.9050% (minimum 99%, Missing); amygdala: 93.1350% (minimum 99%, Missing); basal ganglia: 93.1350% (minimum 99%, Missing); bone marrow: 90.0442% (minimum 99%, Missing); cerebellum: 84.6154% (minimum 99%, Missing); cerebral cortex: 79.6477% (minimum 99%, Missing); choroid plexus: 95.3162% (minimum 99%, Missing); colon: 92.7107% (minimum 97%, Missing); duodenum: 93.5632% (minimum 99%, Missing); esophagus: 90.6459% (minimum 97%, Missing); heart muscle: 90.2439% (minimum 99%, Missing); hippocampal formation: 93.1350% (minimum 99%, Missing); hypothalamus: 93.1350% (minimum 99%, Missing); kidney: 88.4783% (minimum 99%, Missing); liver: 93.9954% (minimum 95%, Enhanced); lung: 87.3391% (minimum 95%, Enhanced); midbrain: 92.9224% (minimum 99%, Missing); pancreas: 94.6512% (minimum 95%, Enhanced); parathyroid gland: 85.3249% (minimum 97%, Missing); pituitary gland: 90.0442% (minimum 99%, Missing); rectum: 92.5000% (minimum 97%, Missing); retina: 67.6080% (minimum 99%, Missing); salivary gland: 90.6459% (minimum 97%, Missing); skeletal muscle: 76.2172% (minimum 99%, Missing); skin: 90.8482% (minimum 95%, Missing); small intestine: 92.7107% (minimum 99%, Missing); smooth muscle: 86.0465% (minimum 95%, Enhanced); spinal cord: 92.9224% (minimum 99%, Missing); stomach: 91.6667% (minimum 97%, Missing); thymus: 80.9145% (minimum 95%, Missing); thyroid gland: 78.5714% (minimum 95%, Missing); tongue: 76.6478% (minimum 97%, Missing)",-0.164286,-0.203522,-0.31392,0,8,partial,19.5,12.4,11.1,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 2); thyroid gland: 11.1 nTPM (manageable, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); cerebellum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 2); smooth muscle: 6.6 nTPM (vital, limit 6); adrenal gland: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); salivary gland: 4.2 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in granular layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196911,KPNA5,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 67.6080% (minimum 75%, Missing)",0.135714,0.0664783,-0.0739203,0,8,partial,19.5,12.4,11.1,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 2); thyroid gland: 11.1 nTPM (manageable, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); cerebellum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 2); smooth muscle: 6.6 nTPM (vital, limit 6); adrenal gland: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); salivary gland: 4.2 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in granular layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196911,KPNA5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 67.6080% (minimum 75%, Missing)",0.135714,0.0664783,-0.0739203,0,8,partial,19.5,12.4,11.1,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 3); thyroid gland: 11.1 nTPM (manageable, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); cerebellum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 3); smooth muscle: 6.6 nTPM (vital, limit 6); adrenal gland: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); salivary gland: 4.2 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); rectum: 3.3 nTPM (protected, limit 3); colon: 3.2 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in granular layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196911,KPNA5,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 67.6080% (minimum 75%, Missing)",0.135714,0.0664783,-0.0739203,0,8,partial,19.5,12.4,11.1,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 3); thyroid gland: 11.1 nTPM (manageable, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); cerebellum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 3); smooth muscle: 6.6 nTPM (vital, limit 6); adrenal gland: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); salivary gland: 4.2 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); rectum: 3.3 nTPM (protected, limit 3); colon: 3.2 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in granular layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196911,KPNA5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 67.6080% (minimum 75%, Baseline (adaptation disabled))",0.135714,0.0664783,-0.0739203,0,8,partial,19.5,12.4,11.1,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 3); thyroid gland: 11.1 nTPM (manageable, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 9.4 nTPM (protected, limit 3); cerebellum: 7.4 nTPM (vital, limit 1); spleen: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 3); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); bone marrow: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); salivary gland: 4.2 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); rectum: 3.3 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in granular layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196911,KPNA5,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 56.7164% (minimum 95%, Missing); adrenal gland: 73.0769% (minimum 99%, Missing); amygdala: 63.3333% (minimum 99%, Missing); basal ganglia: 60.3175% (minimum 99%, Missing); bone marrow: 33.6283% (minimum 99%, Missing); cerebellum: 29.9213% (minimum 99%, Missing); cerebral cortex: 60.3175% (minimum 99%, Missing); choroid plexus: 90.4762% (minimum 99%, Missing); colon: 60.3175% (minimum 97%, Missing); duodenum: 82.6087% (minimum 99%, Missing); esophagus: 73.0769% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 59.3750% (minimum 99%, Missing); hypothalamus: 64.4068% (minimum 99%, Missing); kidney: 71.6981% (minimum 99%, Missing); liver: 82.6087% (minimum 99%, Missing); lung: 64.4068% (minimum 99%, Missing); lymph node: 64.4068% (minimum 97%, Missing); midbrain: 63.3333% (minimum 99%, Missing); pancreas: 48.1013% (minimum 99%, Missing); parathyroid gland: 82.6087% (minimum 97%, Missing); pituitary gland: 61.2903% (minimum 99%, Missing); rectum: 65.5172% (minimum 97%, Missing); retina: 55.8824% (minimum 99%, Missing); salivary gland: 51.3514% (minimum 97%, Missing); skeletal muscle: 84.4444% (minimum 99%, Missing); skin: 55.8824% (minimum 95%, Missing); small intestine: 62.2951% (minimum 99%, Missing); smooth muscle: 76.0000% (minimum 99%, Missing); spinal cord: 55.8824% (minimum 99%, Missing); spleen: 64.4068% (minimum 95%, Missing); stomach: 63.3333% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 62.2951% (minimum 95%, Missing); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 64.4068% (minimum 97%, Missing)",-0.391176,-0.456486,-0.690787,0,80,unavailable,8.9,3.6,3,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); hypothalamus: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196912,ANKRD36B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 56.7164% (minimum 65%, Missing); adrenal gland: 73.0769% (minimum 75%, Missing); amygdala: 63.3333% (minimum 75%, Missing); basal ganglia: 60.3175% (minimum 75%, Missing); bone marrow: 33.6283% (minimum 75%, Missing); cerebellum: 29.9213% (minimum 75%, Missing); cerebral cortex: 60.3175% (minimum 75%, Missing); colon: 60.3175% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 64.4068% (minimum 75%, Missing); kidney: 71.6981% (minimum 75%, Missing); lung: 64.4068% (minimum 75%, Missing); lymph node: 64.4068% (minimum 70%, Missing); midbrain: 63.3333% (minimum 75%, Missing); pancreas: 48.1013% (minimum 75%, Missing); pituitary gland: 61.2903% (minimum 75%, Missing); rectum: 65.5172% (minimum 70%, Missing); retina: 55.8824% (minimum 75%, Missing); salivary gland: 51.3514% (minimum 70%, Missing); skin: 55.8824% (minimum 65%, Missing); small intestine: 62.2951% (minimum 75%, Missing); spinal cord: 55.8824% (minimum 75%, Missing); spleen: 64.4068% (minimum 65%, Missing); stomach: 63.3333% (minimum 70%, Missing); thyroid gland: 62.2951% (minimum 65%, Missing); urinary bladder: 64.4068% (minimum 70%, Missing)",-0.0911765,-0.186486,-0.450787,0,80,unavailable,8.9,3.6,3,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); hypothalamus: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196912,ANKRD36B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 56.7164% (minimum 65%, Missing); adrenal gland: 73.0769% (minimum 75%, Missing); amygdala: 63.3333% (minimum 75%, Missing); basal ganglia: 60.3175% (minimum 75%, Missing); bone marrow: 33.6283% (minimum 75%, Missing); cerebellum: 29.9213% (minimum 75%, Missing); cerebral cortex: 60.3175% (minimum 75%, Missing); colon: 60.3175% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 64.4068% (minimum 75%, Missing); kidney: 71.6981% (minimum 75%, Missing); lung: 64.4068% (minimum 75%, Missing); lymph node: 64.4068% (minimum 70%, Missing); midbrain: 63.3333% (minimum 75%, Missing); pancreas: 48.1013% (minimum 75%, Missing); pituitary gland: 61.2903% (minimum 75%, Missing); rectum: 65.5172% (minimum 70%, Missing); retina: 55.8824% (minimum 75%, Missing); salivary gland: 51.3514% (minimum 70%, Missing); skin: 55.8824% (minimum 65%, Missing); small intestine: 62.2951% (minimum 75%, Missing); spinal cord: 55.8824% (minimum 75%, Missing); spleen: 64.4068% (minimum 65%, Missing); stomach: 63.3333% (minimum 70%, Missing); thyroid gland: 62.2951% (minimum 65%, Missing); urinary bladder: 64.4068% (minimum 70%, Missing)",-0.0911765,-0.186486,-0.450787,0,80,unavailable,8.9,3.6,3,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); spinal cord: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196912,ANKRD36B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 56.7164% (minimum 65%, Missing); adrenal gland: 73.0769% (minimum 75%, Missing); amygdala: 63.3333% (minimum 75%, Missing); basal ganglia: 60.3175% (minimum 75%, Missing); bone marrow: 33.6283% (minimum 75%, Missing); cerebellum: 29.9213% (minimum 75%, Missing); cerebral cortex: 60.3175% (minimum 75%, Missing); colon: 60.3175% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 64.4068% (minimum 75%, Missing); kidney: 71.6981% (minimum 75%, Missing); lung: 64.4068% (minimum 75%, Missing); lymph node: 64.4068% (minimum 70%, Missing); midbrain: 63.3333% (minimum 75%, Missing); pancreas: 48.1013% (minimum 75%, Missing); pituitary gland: 61.2903% (minimum 75%, Missing); rectum: 65.5172% (minimum 70%, Missing); retina: 55.8824% (minimum 75%, Missing); salivary gland: 51.3514% (minimum 70%, Missing); skin: 55.8824% (minimum 65%, Missing); small intestine: 62.2951% (minimum 75%, Missing); spinal cord: 55.8824% (minimum 75%, Missing); spleen: 64.4068% (minimum 65%, Missing); stomach: 63.3333% (minimum 70%, Missing); thyroid gland: 62.2951% (minimum 65%, Missing); urinary bladder: 64.4068% (minimum 70%, Missing)",-0.0911765,-0.186486,-0.450787,0,80,unavailable,8.9,3.6,3,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); spinal cord: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196912,ANKRD36B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 56.7164% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 73.0769% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.3175% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 33.6283% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 29.9213% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.3175% (minimum 75%, Baseline (adaptation disabled)); colon: 60.3175% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 59.3750% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.4068% (minimum 75%, Baseline (adaptation disabled)); kidney: 71.6981% (minimum 75%, Baseline (adaptation disabled)); lung: 64.4068% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.4068% (minimum 70%, Baseline (adaptation disabled)); midbrain: 63.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 48.1013% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 61.2903% (minimum 75%, Baseline (adaptation disabled)); rectum: 65.5172% (minimum 70%, Baseline (adaptation disabled)); retina: 55.8824% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.3514% (minimum 70%, Baseline (adaptation disabled)); skin: 55.8824% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.2951% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 55.8824% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.4068% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.3333% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 62.2951% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 64.4068% (minimum 70%, Baseline (adaptation disabled))",-0.0911765,-0.186486,-0.450787,0,80,unavailable,8.9,3.6,3,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); spinal cord: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196912,ANKRD36B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.1852% (minimum 99%, Missing); cerebral cortex: 62.1622% (minimum 99%, Missing); choroid plexus: 79.3103% (minimum 99%, Missing); colon: 88.4615% (minimum 97%, Missing); esophagus: 88.4615% (minimum 97%, Missing); heart muscle: 88.4615% (minimum 99%, Missing); kidney: 88.4615% (minimum 99%, Missing); lung: 88.4615% (minimum 99%, Missing); lymph node: 79.3103% (minimum 97%, Missing); parathyroid gland: 79.3103% (minimum 97%, Missing); rectum: 88.4615% (minimum 97%, Missing); retina: 85.1852% (minimum 99%, Missing); salivary gland: 85.1852% (minimum 97%, Missing); skin: 92.0000% (minimum 95%, Missing); small intestine: 95.8333% (minimum 99%, Missing); smooth muscle: 74.1935% (minimum 99%, Missing); stomach: 95.8333% (minimum 97%, Missing); thymus: 85.1852% (minimum 95%, Missing); thyroid gland: 65.7143% (minimum 95%, Missing); urinary bladder: 85.1852% (minimum 97%, Missing)",-0.292857,-0.176897,-0.368378,0,80,unavailable,1.4,0.6,1.2,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196946,ZNF705A,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 62.1622% (minimum 75%, Missing); smooth muscle: 74.1935% (minimum 75%, Missing)",0.00714286,0.0931034,-0.128378,0,80,unavailable,1.4,0.6,1.2,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196946,ZNF705A,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 62.1622% (minimum 75%, Missing); smooth muscle: 74.1935% (minimum 75%, Missing)",0.00714286,0.0931034,-0.128378,0,80,unavailable,1.4,0.6,1.2,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196946,ZNF705A,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 62.1622% (minimum 75%, Missing); smooth muscle: 74.1935% (minimum 75%, Missing)",0.00714286,0.0931034,-0.128378,0,80,unavailable,1.4,0.6,1.2,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196946,ZNF705A,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 62.1622% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 74.1935% (minimum 75%, Baseline (adaptation disabled))",0.00714286,0.0931034,-0.128378,0,80,unavailable,1.4,0.6,1.2,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000196946,ZNF705A,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0526% (minimum 95%, Missing); adrenal gland: 65.9091% (minimum 99%, Missing); amygdala: 75.3247% (minimum 99%, Missing); basal ganglia: 74.3590% (minimum 99%, Missing); bone marrow: 76.3158% (minimum 98%, Approved); cerebellum: 68.2353% (minimum 98%, Approved); cerebral cortex: 75.3247% (minimum 99%, Missing); choroid plexus: 65.1685% (minimum 99%, Missing); colon: 63.7363% (minimum 97%, Missing); duodenum: 72.5000% (minimum 99%, Missing); esophagus: 75.3247% (minimum 97%, Missing); heart muscle: 60.4167% (minimum 99%, Missing); hippocampal formation: 73.4177% (minimum 99%, Missing); hypothalamus: 77.3333% (minimum 99%, Missing); kidney: 50.4348% (minimum 99%, Missing); liver: 70.7317% (minimum 99%, Missing); lung: 67.4419% (minimum 99%, Missing); lymph node: 62.3656% (minimum 97%, Missing); midbrain: 71.6049% (minimum 99%, Missing); pancreas: 56.8627% (minimum 99%, Missing); parathyroid gland: 55.7692% (minimum 97%, Missing); pituitary gland: 67.4419% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 46.4000% (minimum 99%, Missing); salivary gland: 64.4444% (minimum 97%, Missing); skeletal muscle: 75.3247% (minimum 98%, Approved); skin: 68.2353% (minimum 95%, Missing); small intestine: 58.0000% (minimum 99%, Missing); smooth muscle: 73.4177% (minimum 99%, Missing); spinal cord: 74.3590% (minimum 99%, Missing); spleen: 52.7273% (minimum 95%, Missing); stomach: 63.0435% (minimum 97%, Missing); thymus: 58.0000% (minimum 95%, Missing); thyroid gland: 55.2381% (minimum 95%, Missing); tongue: 79.4521% (minimum 97%, Missing); urinary bladder: 63.0435% (minimum 97%, Missing)",-0.422727,-0.412308,-0.526,0,5,partial,6.7,4.6,5.2,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4.6 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 2); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197054,ZNF763,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0526% (minimum 65%, Missing); adrenal gland: 65.9091% (minimum 75%, Missing); basal ganglia: 74.3590% (minimum 75%, Missing); cerebellum: 68.2353% (minimum 70%, Approved); choroid plexus: 65.1685% (minimum 75%, Missing); colon: 63.7363% (minimum 70%, Missing); duodenum: 72.5000% (minimum 75%, Missing); heart muscle: 60.4167% (minimum 75%, Missing); hippocampal formation: 73.4177% (minimum 75%, Missing); kidney: 50.4348% (minimum 75%, Missing); liver: 70.7317% (minimum 75%, Missing); lung: 67.4419% (minimum 75%, Missing); lymph node: 62.3656% (minimum 70%, Missing); midbrain: 71.6049% (minimum 75%, Missing); pancreas: 56.8627% (minimum 75%, Missing); parathyroid gland: 55.7692% (minimum 70%, Missing); pituitary gland: 67.4419% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 46.4000% (minimum 75%, Missing); salivary gland: 64.4444% (minimum 70%, Missing); small intestine: 58.0000% (minimum 75%, Missing); smooth muscle: 73.4177% (minimum 75%, Missing); spinal cord: 74.3590% (minimum 75%, Missing); spleen: 52.7273% (minimum 65%, Missing); stomach: 63.0435% (minimum 70%, Missing); thymus: 58.0000% (minimum 65%, Missing); thyroid gland: 55.2381% (minimum 65%, Missing); urinary bladder: 63.0435% (minimum 70%, Missing)",-0.122727,-0.142308,-0.286,0,5,partial,6.7,4.6,5.2,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4.6 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 2); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197054,ZNF763,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0526% (minimum 65%, Missing); adrenal gland: 65.9091% (minimum 75%, Missing); basal ganglia: 74.3590% (minimum 75%, Missing); cerebellum: 68.2353% (minimum 70%, Approved); choroid plexus: 65.1685% (minimum 75%, Missing); colon: 63.7363% (minimum 70%, Missing); duodenum: 72.5000% (minimum 75%, Missing); heart muscle: 60.4167% (minimum 75%, Missing); hippocampal formation: 73.4177% (minimum 75%, Missing); kidney: 50.4348% (minimum 75%, Missing); liver: 70.7317% (minimum 75%, Missing); lung: 67.4419% (minimum 75%, Missing); lymph node: 62.3656% (minimum 70%, Missing); midbrain: 71.6049% (minimum 75%, Missing); pancreas: 56.8627% (minimum 75%, Missing); parathyroid gland: 55.7692% (minimum 70%, Missing); pituitary gland: 67.4419% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 46.4000% (minimum 75%, Missing); salivary gland: 64.4444% (minimum 70%, Missing); small intestine: 58.0000% (minimum 75%, Missing); smooth muscle: 73.4177% (minimum 75%, Missing); spinal cord: 74.3590% (minimum 75%, Missing); spleen: 52.7273% (minimum 65%, Missing); stomach: 63.0435% (minimum 70%, Missing); thymus: 58.0000% (minimum 65%, Missing); thyroid gland: 55.2381% (minimum 65%, Missing); urinary bladder: 63.0435% (minimum 70%, Missing)",-0.122727,-0.142308,-0.286,0,5,partial,6.7,4.6,5.2,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4.6 nTPM (protected, limit 3); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); stomach: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 2); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197054,ZNF763,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0526% (minimum 65%, Missing); adrenal gland: 65.9091% (minimum 75%, Missing); basal ganglia: 74.3590% (minimum 75%, Missing); cerebellum: 68.2353% (minimum 70%, Approved); choroid plexus: 65.1685% (minimum 75%, Missing); colon: 63.7363% (minimum 70%, Missing); duodenum: 72.5000% (minimum 75%, Missing); heart muscle: 60.4167% (minimum 75%, Missing); hippocampal formation: 73.4177% (minimum 75%, Missing); kidney: 50.4348% (minimum 75%, Missing); liver: 70.7317% (minimum 75%, Missing); lung: 67.4419% (minimum 75%, Missing); lymph node: 62.3656% (minimum 70%, Missing); midbrain: 71.6049% (minimum 75%, Missing); pancreas: 56.8627% (minimum 75%, Missing); parathyroid gland: 55.7692% (minimum 70%, Missing); pituitary gland: 67.4419% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 46.4000% (minimum 75%, Missing); salivary gland: 64.4444% (minimum 70%, Missing); small intestine: 58.0000% (minimum 75%, Missing); smooth muscle: 73.4177% (minimum 75%, Missing); spinal cord: 74.3590% (minimum 75%, Missing); spleen: 52.7273% (minimum 65%, Missing); stomach: 63.0435% (minimum 70%, Missing); thymus: 58.0000% (minimum 65%, Missing); thyroid gland: 55.2381% (minimum 65%, Missing); urinary bladder: 63.0435% (minimum 70%, Missing)",-0.122727,-0.142308,-0.286,0,5,partial,6.7,4.6,5.2,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4.6 nTPM (protected, limit 3); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); stomach: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 2); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197054,ZNF763,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0526% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 65.9091% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.3590% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.2353% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 65.1685% (minimum 75%, Baseline (adaptation disabled)); colon: 63.7363% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.5000% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 60.4167% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.4177% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.4348% (minimum 75%, Baseline (adaptation disabled)); liver: 70.7317% (minimum 75%, Baseline (adaptation disabled)); lung: 67.4419% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.3656% (minimum 70%, Baseline (adaptation disabled)); midbrain: 71.6049% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.8627% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.7692% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.4419% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 46.4000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.4444% (minimum 70%, Baseline (adaptation disabled)); small intestine: 58.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.4177% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.3590% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.7273% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.0435% (minimum 70%, Baseline (adaptation disabled)); thymus: 58.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.2381% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 63.0435% (minimum 70%, Baseline (adaptation disabled))",-0.122727,-0.142308,-0.286,0,5,partial,6.7,4.6,5.2,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4.6 nTPM (protected, limit 3); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); stomach: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197054,ZNF763,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 5.0000% (minimum 60%, Enhanced); salivary gland: 14.2857% (minimum 80%, Enhanced); skin: 0.1773% (minimum 60%, Enhanced); spleen: 50.0000% (minimum 60%, Enhanced)",-0.598227,-0.657143,0.01,0,6,partial,0,0.6,56.3,"skin: 56.3 nTPM (manageable, limit 30)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197079,KRT35,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 5.0000% (minimum 50%, Enhanced); salivary gland: 14.2857% (minimum 55%, Enhanced); skin: 0.1773% (minimum 50%, Enhanced)",-0.498227,-0.407143,0.25,0,6,partial,0,0.6,56.3,"skin: 56.3 nTPM (manageable, limit 30)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197079,KRT35,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 5.0000% (minimum 50%, Enhanced); salivary gland: 14.2857% (minimum 55%, Enhanced); skin: 0.1773% (minimum 50%, Enhanced)",-0.498227,-0.407143,0.25,0,6,partial,0,0.6,56.3,"skin: 56.3 nTPM (manageable, limit 30)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197079,KRT35,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 5.0000% (minimum 50%, Enhanced); salivary gland: 14.2857% (minimum 55%, Enhanced); skin: 0.1773% (minimum 50%, Enhanced)",-0.498227,-0.407143,0.25,0,6,partial,0,0.6,56.3,"skin: 56.3 nTPM (manageable, limit 30)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197079,KRT35,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 5.0000% (minimum 65%, Baseline (adaptation disabled)); salivary gland: 14.2857% (minimum 70%, Baseline (adaptation disabled)); skin: 0.1773% (minimum 65%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled))",-0.648227,-0.557143,0.25,0,6,partial,0,0.6,56.3,"skin: 56.3 nTPM (manageable, limit 5)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197079,KRT35,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197123,ZNF679,admission_only,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197123,ZNF679,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197123,ZNF679,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197123,ZNF679,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197123,ZNF679,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.8710% (minimum 95%, Missing); adrenal gland: 83.8710% (minimum 99%, Missing); amygdala: 92.8571% (minimum 99%, Missing); basal ganglia: 89.6552% (minimum 99%, Missing); bone marrow: 38.8060% (minimum 99%, Missing); cerebellum: 92.8571% (minimum 99%, Missing); cerebral cortex: 76.4706% (minimum 99%, Missing); choroid plexus: 83.8710% (minimum 99%, Missing); colon: 78.7879% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); esophagus: 89.6552% (minimum 97%, Missing); heart muscle: 81.2500% (minimum 99%, Missing); hippocampal formation: 92.8571% (minimum 99%, Missing); hypothalamus: 92.8571% (minimum 99%, Missing); kidney: 81.2500% (minimum 99%, Missing); liver: 86.6667% (minimum 99%, Missing); lung: 76.4706% (minimum 99%, Missing); lymph node: 50.9804% (minimum 97%, Missing); midbrain: 86.6667% (minimum 99%, Missing); pancreas: 55.3191% (minimum 99%, Missing); parathyroid gland: 72.2222% (minimum 97%, Missing); pituitary gland: 92.8571% (minimum 99%, Missing); rectum: 83.8710% (minimum 97%, Missing); retina: 78.7879% (minimum 99%, Missing); salivary gland: 89.6552% (minimum 97%, Missing); skeletal muscle: 92.8571% (minimum 99%, Missing); skin: 74.2857% (minimum 95%, Missing); small intestine: 86.6667% (minimum 99%, Missing); smooth muscle: 76.4706% (minimum 99%, Missing); spinal cord: 81.2500% (minimum 99%, Missing); spleen: 61.9048% (minimum 95%, Missing); stomach: 65.0000% (minimum 97%, Missing); thymus: 61.9048% (minimum 95%, Missing); thyroid gland: 54.1667% (minimum 95%, Missing); urinary bladder: 72.2222% (minimum 97%, Missing)",-0.408333,-0.460196,-0.60194,0,80,unavailable,4.1,2.5,2.2,"bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197134,ZNF257,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 38.8060% (minimum 75%, Missing); lymph node: 50.9804% (minimum 70%, Missing); pancreas: 55.3191% (minimum 75%, Missing); spleen: 61.9048% (minimum 65%, Missing); stomach: 65.0000% (minimum 70%, Missing); thymus: 61.9048% (minimum 65%, Missing); thyroid gland: 54.1667% (minimum 65%, Missing)",-0.108333,-0.190196,-0.36194,0,80,unavailable,4.1,2.5,2.2,"bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197134,ZNF257,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 38.8060% (minimum 75%, Missing); lymph node: 50.9804% (minimum 70%, Missing); pancreas: 55.3191% (minimum 75%, Missing); spleen: 61.9048% (minimum 65%, Missing); stomach: 65.0000% (minimum 70%, Missing); thymus: 61.9048% (minimum 65%, Missing); thyroid gland: 54.1667% (minimum 65%, Missing)",-0.108333,-0.190196,-0.36194,0,80,unavailable,4.1,2.5,2.2,"bone marrow: 4.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197134,ZNF257,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 38.8060% (minimum 75%, Missing); lymph node: 50.9804% (minimum 70%, Missing); pancreas: 55.3191% (minimum 75%, Missing); spleen: 61.9048% (minimum 65%, Missing); stomach: 65.0000% (minimum 70%, Missing); thymus: 61.9048% (minimum 65%, Missing); thyroid gland: 54.1667% (minimum 65%, Missing)",-0.108333,-0.190196,-0.36194,0,80,unavailable,4.1,2.5,2.2,"bone marrow: 4.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197134,ZNF257,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 38.8060% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.9804% (minimum 70%, Baseline (adaptation disabled)); pancreas: 55.3191% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.9048% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 61.9048% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.1667% (minimum 65%, Baseline (adaptation disabled))",-0.108333,-0.190196,-0.36194,0,80,unavailable,4.1,2.5,2.2,"bone marrow: 4.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197134,ZNF257,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.1550% (minimum 99%, Missing); basal ganglia: 98.5185% (minimum 99%, Missing); hippocampal formation: 97.7941% (minimum 99%, Missing); hypothalamus: 96.7273% (minimum 99%, Missing); midbrain: 98.1550% (minimum 99%, Missing); pancreas: 93.9929% (minimum 95%, Enhanced); pituitary gland: 98.5185% (minimum 99%, Missing); retina: 96.7273% (minimum 99%, Missing); spinal cord: 98.5185% (minimum 99%, Missing)",0.05,0.0262547,-0.0227273,0,6,partial,1.7,0.5,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197140,ADAM32,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.296255,0.217273,0,6,partial,1.7,0.5,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197140,ADAM32,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.296255,0.217273,0,6,partial,1.7,0.5,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197140,ADAM32,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.296255,0.217273,0,6,partial,1.7,0.5,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197140,ADAM32,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317273,0.28155,0.189929,0,6,partial,1.7,0.5,0.9,"pancreas: 1.7 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197140,ADAM32,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"amygdala: 50.0000% (minimum 99%, Missing); bone marrow: 20.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); esophagus: 75.0000% (minimum 97%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 23.0769% (minimum 97%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); spleen: 42.8571% (minimum 95%, Missing); thymus: 21.4286% (minimum 95%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.735714,-0.739231,-0.79,0,7,partial,1.2,1,1.1,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197153,H3C12,admission_only,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"amygdala: 50.0000% (minimum 75%, Missing); bone marrow: 20.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 23.0769% (minimum 70%, Missing); small intestine: 75.0000% (minimum 75%, Missing); spleen: 42.8571% (minimum 65%, Missing); thymus: 21.4286% (minimum 65%, Missing)",-0.435714,-0.469231,-0.55,0,7,partial,1.2,1,1.1,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197153,H3C12,selectivity_revised,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"amygdala: 50.0000% (minimum 75%, Missing); bone marrow: 20.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 23.0769% (minimum 70%, Missing); small intestine: 75.0000% (minimum 75%, Missing); spleen: 42.8571% (minimum 65%, Missing); thymus: 21.4286% (minimum 65%, Missing)",-0.435714,-0.469231,-0.55,0,7,partial,1.2,1,1.1,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197153,H3C12,grid_revised,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"amygdala: 50.0000% (minimum 75%, Missing); bone marrow: 20.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 23.0769% (minimum 70%, Missing); small intestine: 75.0000% (minimum 75%, Missing); spleen: 42.8571% (minimum 65%, Missing); thymus: 21.4286% (minimum 65%, Missing)",-0.435714,-0.469231,-0.55,0,7,partial,1.2,1,1.1,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197153,H3C12,current_adaptive,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"amygdala: 50.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 20.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 23.0769% (minimum 70%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 42.8571% (minimum 65%, Baseline (adaptation disabled)); thymus: 21.4286% (minimum 65%, Baseline (adaptation disabled))",-0.435714,-0.469231,-0.55,0,7,partial,1.2,1,1.1,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197153,H3C12,current_fixed,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.5714% (minimum 99%, Missing)",0.021831,0.03,-0.00428571,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197172,MAGEA6,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321831,0.3,0.235714,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197172,MAGEA6,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321831,0.3,0.235714,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197172,MAGEA6,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321831,0.3,0.235714,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197172,MAGEA6,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.321831,0.3,0.235714,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197172,MAGEA6,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2394% (minimum 99%, Missing); basal ganglia: 97.5524% (minimum 99%, Missing); cerebellum: 96.8750% (minimum 99%, Missing); cerebral cortex: 98.5866% (minimum 99%, Missing); colon: 96.8750% (minimum 97%, Missing); duodenum: 82.7893% (minimum 99%, Missing); heart muscle: 98.2394% (minimum 99%, Missing); hippocampal formation: 97.8947% (minimum 99%, Missing); hypothalamus: 96.5398% (minimum 99%, Missing); kidney: 98.9362% (minimum 99%, Missing); liver: 96.5398% (minimum 99%, Missing); lung: 98.9362% (minimum 99%, Missing); midbrain: 97.5524% (minimum 99%, Missing); pancreas: 92.3841% (minimum 99%, Missing); pituitary gland: 94.8980% (minimum 99%, Missing); rectum: 96.8750% (minimum 97%, Missing); retina: 96.8750% (minimum 99%, Missing); skeletal muscle: 92.0792% (minimum 99%, Missing); small intestine: 93.9394% (minimum 99%, Missing); smooth muscle: 98.2394% (minimum 99%, Missing); spinal cord: 98.2394% (minimum 99%, Missing); stomach: 95.2218% (minimum 97%, Missing); tongue: 96.5398% (minimum 97%, Missing)",0.012069,-0.0177816,-0.162107,0,80,unavailable,5.8,1.4,1.1,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197181,PIWIL2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312069,0.252218,0.0778932,0,80,unavailable,5.8,1.4,1.1,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197181,PIWIL2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312069,0.252218,0.0778932,0,80,unavailable,5.8,1.4,1.1,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197181,PIWIL2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312069,0.252218,0.0778932,0,80,unavailable,5.8,1.4,1.1,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197181,PIWIL2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312069,0.252218,0.0778932,0,80,unavailable,5.8,1.4,1.1,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197181,PIWIL2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.2144% (minimum 95%, Missing); adrenal gland: 83.2685% (minimum 95%, Enhanced); amygdala: 76.7025% (minimum 99%, Missing); basal ganglia: 82.1497% (minimum 99%, Missing); bone marrow: 67.1900% (minimum 95%, Enhanced); cerebellum: 69.1438% (minimum 99%, Missing); cerebral cortex: 77.6770% (minimum 99%, Missing); choroid plexus: 82.4663% (minimum 99%, Missing); colon: 72.0539% (minimum 97%, Missing); duodenum: 69.7068% (minimum 99%, Missing); esophagus: 94.6903% (minimum 97%, Missing); heart muscle: 89.1667% (minimum 95%, Enhanced); hippocampal formation: 74.5645% (minimum 99%, Missing); hypothalamus: 78.1022% (minimum 99%, Missing); kidney: 75.3521% (minimum 99%, Missing); liver: 86.4646% (minimum 95%, Enhanced); lung: 77.1171% (minimum 99%, Missing); lymph node: 84.0864% (minimum 97%, Missing); midbrain: 78.1022% (minimum 99%, Missing); pancreas: 80.0000% (minimum 99%, Missing); pituitary gland: 66.4596% (minimum 99%, Missing); rectum: 76.4286% (minimum 97%, Missing); retina: 47.1366% (minimum 99%, Missing); salivary gland: 81.8356% (minimum 97%, Missing); skin: 92.8416% (minimum 95%, Missing); small intestine: 68.5897% (minimum 99%, Missing); smooth muscle: 87.1690% (minimum 99%, Missing); spinal cord: 67.4016% (minimum 99%, Missing); spleen: 77.2563% (minimum 95%, Missing); stomach: 76.7025% (minimum 97%, Missing); thymus: 73.5395% (minimum 95%, Missing); thyroid gland: 82.1497% (minimum 95%, Missing); tongue: 96.3964% (minimum 97%, Missing); urinary bladder: 82.1497% (minimum 97%, Missing)",-0.214605,-0.249461,-0.518634,0,4,partial,48,16.6,15.4,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 6); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 2); thymus: 15.4 nTPM (manageable, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 2); amygdala: 13 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); lung: 12.7 nTPM (vital, limit 1); spleen: 12.6 nTPM (manageable, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 2); basal ganglia: 9.3 nTPM (vital, limit 1); thyroid gland: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 2); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 6); lymph node: 8.1 nTPM (protected, limit 2); liver: 6.7 nTPM (vital, limit 6); smooth muscle: 6.3 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197183,NOL4L,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 69.1438% (minimum 75%, Missing); duodenum: 69.7068% (minimum 75%, Missing); hippocampal formation: 74.5645% (minimum 75%, Missing); pituitary gland: 66.4596% (minimum 75%, Missing); retina: 47.1366% (minimum 75%, Missing); small intestine: 68.5897% (minimum 75%, Missing); spinal cord: 67.4016% (minimum 75%, Missing)",0.0853952,0.0205387,-0.278634,0,4,partial,48,16.6,15.4,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 6); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 2); thymus: 15.4 nTPM (manageable, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 2); amygdala: 13 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); lung: 12.7 nTPM (vital, limit 1); spleen: 12.6 nTPM (manageable, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 2); basal ganglia: 9.3 nTPM (vital, limit 1); thyroid gland: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 2); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 6); lymph node: 8.1 nTPM (protected, limit 2); liver: 6.7 nTPM (vital, limit 6); smooth muscle: 6.3 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197183,NOL4L,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 69.1438% (minimum 75%, Missing); duodenum: 69.7068% (minimum 75%, Missing); hippocampal formation: 74.5645% (minimum 75%, Missing); pituitary gland: 66.4596% (minimum 75%, Missing); retina: 47.1366% (minimum 75%, Missing); small intestine: 68.5897% (minimum 75%, Missing); spinal cord: 67.4016% (minimum 75%, Missing)",0.0853952,0.0205387,-0.278634,0,4,partial,48,16.6,15.4,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 6); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 3); thymus: 15.4 nTPM (manageable, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 3); amygdala: 13 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 3); lung: 12.7 nTPM (vital, limit 1); spleen: 12.6 nTPM (manageable, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 3); thyroid gland: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 3); basal ganglia: 9.3 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 6); lymph node: 8.1 nTPM (protected, limit 3); liver: 6.7 nTPM (vital, limit 6); smooth muscle: 6.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197183,NOL4L,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 69.1438% (minimum 75%, Missing); duodenum: 69.7068% (minimum 75%, Missing); hippocampal formation: 74.5645% (minimum 75%, Missing); pituitary gland: 66.4596% (minimum 75%, Missing); retina: 47.1366% (minimum 75%, Missing); small intestine: 68.5897% (minimum 75%, Missing); spinal cord: 67.4016% (minimum 75%, Missing)",0.0853952,0.0205387,-0.278634,0,4,partial,48,16.6,15.4,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 6); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 3); thymus: 15.4 nTPM (manageable, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 3); amygdala: 13 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 3); lung: 12.7 nTPM (vital, limit 1); spleen: 12.6 nTPM (manageable, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 3); thyroid gland: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 3); basal ganglia: 9.3 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 6); lymph node: 8.1 nTPM (protected, limit 3); liver: 6.7 nTPM (vital, limit 6); smooth muscle: 6.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197183,NOL4L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 67.1900% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 69.1438% (minimum 75%, Baseline (adaptation disabled)); duodenum: 69.7068% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.5645% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 66.4596% (minimum 75%, Baseline (adaptation disabled)); retina: 47.1366% (minimum 75%, Baseline (adaptation disabled)); small intestine: 68.5897% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.4016% (minimum 75%, Baseline (adaptation disabled))",0.0853952,0.0205387,-0.278634,0,4,partial,48,16.6,15.4,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 1); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 3); thymus: 15.4 nTPM (manageable, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 3); stomach: 13 nTPM (protected, limit 3); amygdala: 13 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 1); spleen: 12.6 nTPM (manageable, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 3); thyroid gland: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 3); basal ganglia: 9.3 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 3); liver: 6.7 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 3); skeletal muscle: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197183,NOL4L,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 89.4737% (minimum 99%, Missing); basal ganglia: 85.0000% (minimum 99%, Missing); cerebral cortex: 94.4444% (minimum 99%, Missing); skin: 94.4444% (minimum 95%, Missing)",-0.00555556,0.03,-0.14,0,1,partial,0.3,0,0.1,,cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197213,ZSCAN5B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.294444,0.3,0.1,0,1,partial,0.3,0,0.1,,cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197213,ZSCAN5B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.294444,0.3,0.1,0,1,partial,0.3,0,0.1,,cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197213,ZSCAN5B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.294444,0.3,0.1,0,1,partial,0.3,0,0.1,,cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197213,ZSCAN5B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.294444,0.3,0.1,0,1,partial,0.3,0,0.1,,cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197213,ZSCAN5B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.1429% (minimum 80%, Supported); adrenal gland: 63.4868% (minimum 99%, Missing); amygdala: 68.1979% (minimum 99%, Missing); basal ganglia: 68.6833% (minimum 99%, Missing); bone marrow: 38.9899% (minimum 99%, Missing); cerebellum: 54.0616% (minimum 99%, Missing); cerebral cortex: 49.1094% (minimum 99%, Missing); choroid plexus: 66.7820% (minimum 99%, Missing); colon: 50.2604% (minimum 97%, Missing); duodenum: 52.4457% (minimum 99%, Missing); esophagus: 61.2698% (minimum 90%, Supported); heart muscle: 48.6146% (minimum 97%, Supported); hippocampal formation: 63.6964% (minimum 99%, Missing); hypothalamus: 65.2027% (minimum 99%, Missing); kidney: 62.0579% (minimum 99%, Missing); liver: 59.0214% (minimum 97%, Supported); lung: 50.0000% (minimum 99%, Missing); lymph node: 40.2923% (minimum 97%, Missing); midbrain: 64.3333% (minimum 99%, Missing); pancreas: 48.1297% (minimum 99%, Missing); parathyroid gland: 42.4176% (minimum 97%, Missing); pituitary gland: 52.0216% (minimum 99%, Missing); rectum: 49.6144% (minimum 97%, Missing); retina: 37.8431% (minimum 99%, Missing); salivary gland: 47.4201% (minimum 97%, Missing); skeletal muscle: 56.7647% (minimum 99%, Missing); skin: 61.4650% (minimum 95%, Missing); small intestine: 43.0804% (minimum 99%, Missing); smooth muscle: 54.8295% (minimum 97%, Supported); spinal cord: 64.1196% (minimum 99%, Missing); spleen: 43.7642% (minimum 95%, Missing); stomach: 49.4872% (minimum 97%, Missing); thymus: 57.7844% (minimum 95%, Missing); thyroid gland: 57.6119% (minimum 95%, Missing); tongue: 55.7803% (minimum 97%, Missing); urinary bladder: 54.5198% (minimum 97%, Missing)",-0.512358,-0.567077,-0.611569,0,13,partial,31.7,28.6,24.8,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 2); parathyroid gland: 26.2 nTPM (protected, limit 2); small intestine: 25.5 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); salivary gland: 21.4 nTPM (protected, limit 2); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 3); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 2); rectum: 19.6 nTPM (protected, limit 2); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 2); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 2); smooth muscle: 15.9 nTPM (vital, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 15); tongue: 15.3 nTPM (protected, limit 2); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (manageable, limit 5); thymus: 14.1 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 3); esophagus: 12.2 nTPM (protected, limit 6); skin: 12.1 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197217,ENTPD4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.4868% (minimum 75%, Missing); amygdala: 68.1979% (minimum 75%, Missing); basal ganglia: 68.6833% (minimum 75%, Missing); bone marrow: 38.9899% (minimum 75%, Missing); cerebellum: 54.0616% (minimum 75%, Missing); cerebral cortex: 49.1094% (minimum 75%, Missing); choroid plexus: 66.7820% (minimum 75%, Missing); colon: 50.2604% (minimum 70%, Missing); duodenum: 52.4457% (minimum 75%, Missing); heart muscle: 48.6146% (minimum 65%, Supported); hippocampal formation: 63.6964% (minimum 75%, Missing); hypothalamus: 65.2027% (minimum 75%, Missing); kidney: 62.0579% (minimum 75%, Missing); liver: 59.0214% (minimum 65%, Supported); lung: 50.0000% (minimum 75%, Missing); lymph node: 40.2923% (minimum 70%, Missing); midbrain: 64.3333% (minimum 75%, Missing); pancreas: 48.1297% (minimum 75%, Missing); parathyroid gland: 42.4176% (minimum 70%, Missing); pituitary gland: 52.0216% (minimum 75%, Missing); rectum: 49.6144% (minimum 70%, Missing); retina: 37.8431% (minimum 75%, Missing); salivary gland: 47.4201% (minimum 70%, Missing); skeletal muscle: 56.7647% (minimum 75%, Missing); skin: 61.4650% (minimum 65%, Missing); small intestine: 43.0804% (minimum 75%, Missing); smooth muscle: 54.8295% (minimum 65%, Supported); spinal cord: 64.1196% (minimum 75%, Missing); spleen: 43.7642% (minimum 65%, Missing); stomach: 49.4872% (minimum 70%, Missing); thymus: 57.7844% (minimum 65%, Missing); thyroid gland: 57.6119% (minimum 65%, Missing); tongue: 55.7803% (minimum 70%, Missing); urinary bladder: 54.5198% (minimum 70%, Missing)",-0.212358,-0.297077,-0.371569,0,13,partial,31.7,28.6,24.8,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 2); parathyroid gland: 26.2 nTPM (protected, limit 2); small intestine: 25.5 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); salivary gland: 21.4 nTPM (protected, limit 2); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 3); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 2); rectum: 19.6 nTPM (protected, limit 2); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 2); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 2); smooth muscle: 15.9 nTPM (vital, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 15); tongue: 15.3 nTPM (protected, limit 2); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (manageable, limit 5); thymus: 14.1 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 3); esophagus: 12.2 nTPM (protected, limit 6); skin: 12.1 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197217,ENTPD4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.4868% (minimum 75%, Missing); amygdala: 68.1979% (minimum 75%, Missing); basal ganglia: 68.6833% (minimum 75%, Missing); bone marrow: 38.9899% (minimum 75%, Missing); cerebellum: 54.0616% (minimum 75%, Missing); cerebral cortex: 49.1094% (minimum 75%, Missing); choroid plexus: 66.7820% (minimum 75%, Missing); colon: 50.2604% (minimum 70%, Missing); duodenum: 52.4457% (minimum 75%, Missing); heart muscle: 48.6146% (minimum 65%, Supported); hippocampal formation: 63.6964% (minimum 75%, Missing); hypothalamus: 65.2027% (minimum 75%, Missing); kidney: 62.0579% (minimum 75%, Missing); liver: 59.0214% (minimum 65%, Supported); lung: 50.0000% (minimum 75%, Missing); lymph node: 40.2923% (minimum 70%, Missing); midbrain: 64.3333% (minimum 75%, Missing); pancreas: 48.1297% (minimum 75%, Missing); parathyroid gland: 42.4176% (minimum 70%, Missing); pituitary gland: 52.0216% (minimum 75%, Missing); rectum: 49.6144% (minimum 70%, Missing); retina: 37.8431% (minimum 75%, Missing); salivary gland: 47.4201% (minimum 70%, Missing); skeletal muscle: 56.7647% (minimum 75%, Missing); skin: 61.4650% (minimum 65%, Missing); small intestine: 43.0804% (minimum 75%, Missing); smooth muscle: 54.8295% (minimum 65%, Supported); spinal cord: 64.1196% (minimum 75%, Missing); spleen: 43.7642% (minimum 65%, Missing); stomach: 49.4872% (minimum 70%, Missing); thymus: 57.7844% (minimum 65%, Missing); thyroid gland: 57.6119% (minimum 65%, Missing); tongue: 55.7803% (minimum 70%, Missing); urinary bladder: 54.5198% (minimum 70%, Missing)",-0.212358,-0.297077,-0.371569,0,13,partial,31.7,28.6,24.8,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 3); parathyroid gland: 26.2 nTPM (protected, limit 3); small intestine: 25.5 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); salivary gland: 21.4 nTPM (protected, limit 3); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 3); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 3); rectum: 19.6 nTPM (protected, limit 3); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 3); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 3); smooth muscle: 15.9 nTPM (vital, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 15); tongue: 15.3 nTPM (protected, limit 3); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (manageable, limit 5); thymus: 14.1 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 3); esophagus: 12.2 nTPM (protected, limit 6); skin: 12.1 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197217,ENTPD4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.4868% (minimum 75%, Missing); amygdala: 68.1979% (minimum 75%, Missing); basal ganglia: 68.6833% (minimum 75%, Missing); bone marrow: 38.9899% (minimum 75%, Missing); cerebellum: 54.0616% (minimum 75%, Missing); cerebral cortex: 49.1094% (minimum 75%, Missing); choroid plexus: 66.7820% (minimum 75%, Missing); colon: 50.2604% (minimum 70%, Missing); duodenum: 52.4457% (minimum 75%, Missing); heart muscle: 48.6146% (minimum 65%, Supported); hippocampal formation: 63.6964% (minimum 75%, Missing); hypothalamus: 65.2027% (minimum 75%, Missing); kidney: 62.0579% (minimum 75%, Missing); liver: 59.0214% (minimum 65%, Supported); lung: 50.0000% (minimum 75%, Missing); lymph node: 40.2923% (minimum 70%, Missing); midbrain: 64.3333% (minimum 75%, Missing); pancreas: 48.1297% (minimum 75%, Missing); parathyroid gland: 42.4176% (minimum 70%, Missing); pituitary gland: 52.0216% (minimum 75%, Missing); rectum: 49.6144% (minimum 70%, Missing); retina: 37.8431% (minimum 75%, Missing); salivary gland: 47.4201% (minimum 70%, Missing); skeletal muscle: 56.7647% (minimum 75%, Missing); skin: 61.4650% (minimum 65%, Missing); small intestine: 43.0804% (minimum 75%, Missing); smooth muscle: 54.8295% (minimum 65%, Supported); spinal cord: 64.1196% (minimum 75%, Missing); spleen: 43.7642% (minimum 65%, Missing); stomach: 49.4872% (minimum 70%, Missing); thymus: 57.7844% (minimum 65%, Missing); thyroid gland: 57.6119% (minimum 65%, Missing); tongue: 55.7803% (minimum 70%, Missing); urinary bladder: 54.5198% (minimum 70%, Missing)",-0.212358,-0.297077,-0.371569,0,13,partial,31.7,28.6,24.8,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 3); parathyroid gland: 26.2 nTPM (protected, limit 3); small intestine: 25.5 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); salivary gland: 21.4 nTPM (protected, limit 3); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 3); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 3); rectum: 19.6 nTPM (protected, limit 3); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 3); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 3); smooth muscle: 15.9 nTPM (vital, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 15); tongue: 15.3 nTPM (protected, limit 3); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (manageable, limit 5); thymus: 14.1 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 3); esophagus: 12.2 nTPM (protected, limit 6); skin: 12.1 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197217,ENTPD4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.1429% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.4868% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.1979% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 68.6833% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 38.9899% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.0616% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 49.1094% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.7820% (minimum 75%, Baseline (adaptation disabled)); colon: 50.2604% (minimum 70%, Baseline (adaptation disabled)); duodenum: 52.4457% (minimum 75%, Baseline (adaptation disabled)); esophagus: 61.2698% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 48.6146% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.6964% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.2027% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.0579% (minimum 75%, Baseline (adaptation disabled)); liver: 59.0214% (minimum 75%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 40.2923% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 48.1297% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 42.4176% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 52.0216% (minimum 75%, Baseline (adaptation disabled)); rectum: 49.6144% (minimum 70%, Baseline (adaptation disabled)); retina: 37.8431% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 47.4201% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 56.7647% (minimum 75%, Baseline (adaptation disabled)); skin: 61.4650% (minimum 65%, Baseline (adaptation disabled)); small intestine: 43.0804% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 54.8295% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.1196% (minimum 75%, Baseline (adaptation disabled)); spleen: 43.7642% (minimum 65%, Baseline (adaptation disabled)); stomach: 49.4872% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.7844% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.6119% (minimum 65%, Baseline (adaptation disabled)); tongue: 55.7803% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 54.5198% (minimum 70%, Baseline (adaptation disabled))",-0.212358,-0.297077,-0.371569,0,13,partial,31.7,28.6,24.8,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 3); parathyroid gland: 26.2 nTPM (protected, limit 3); small intestine: 25.5 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); salivary gland: 21.4 nTPM (protected, limit 3); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 3); rectum: 19.6 nTPM (protected, limit 3); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 3); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 3); smooth muscle: 15.9 nTPM (vital, limit 1); adipose tissue: 15.7 nTPM (manageable, limit 5); tongue: 15.3 nTPM (protected, limit 3); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (manageable, limit 5); thymus: 14.1 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); esophagus: 12.2 nTPM (protected, limit 3); skin: 12.1 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197217,ENTPD4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197233,OR1J2,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197233,OR1J2,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197233,OR1J2,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197233,OR1J2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197233,OR1J2,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.0909% (minimum 95%, Missing); adrenal gland: 87.5000% (minimum 95%, Enhanced); amygdala: 90.7407% (minimum 99%, Missing); basal ganglia: 89.0909% (minimum 99%, Missing); bone marrow: 71.0145% (minimum 99%, Missing); cerebellum: 89.0909% (minimum 99%, Missing); cerebral cortex: 89.0909% (minimum 99%, Missing); choroid plexus: 67.1233% (minimum 99%, Missing); colon: 76.5625% (minimum 97%, Missing); duodenum: 77.7778% (minimum 99%, Missing); esophagus: 79.0323% (minimum 97%, Missing); heart muscle: 89.0909% (minimum 95%, Enhanced); hippocampal formation: 92.4528% (minimum 99%, Missing); hypothalamus: 89.0909% (minimum 99%, Missing); kidney: 85.9649% (minimum 99%, Missing); liver: 77.7778% (minimum 99%, Missing); lung: 87.5000% (minimum 99%, Missing); lymph node: 64.4737% (minimum 97%, Missing); midbrain: 87.5000% (minimum 99%, Missing); pancreas: 85.9649% (minimum 99%, Missing); parathyroid gland: 89.0909% (minimum 97%, Missing); pituitary gland: 81.6667% (minimum 99%, Missing); rectum: 71.0145% (minimum 97%, Missing); retina: 41.8803% (minimum 99%, Missing); salivary gland: 85.9649% (minimum 97%, Missing); skeletal muscle: 94.2308% (minimum 95%, Enhanced); skin: 73.1343% (minimum 95%, Missing); small intestine: 80.3279% (minimum 99%, Missing); smooth muscle: 83.0508% (minimum 95%, Enhanced); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 84.4828% (minimum 95%, Missing); stomach: 76.5625% (minimum 97%, Missing); thymus: 54.4444% (minimum 95%, Missing); thyroid gland: 81.6667% (minimum 95%, Missing); tongue: 94.2308% (minimum 97%, Missing); urinary bladder: 81.6667% (minimum 97%, Missing)",-0.405556,-0.325263,-0.571197,0,4,partial,6.8,2.7,4.1,"retina: 6.8 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197275,RAD54B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 71.0145% (minimum 75%, Missing); choroid plexus: 67.1233% (minimum 75%, Missing); lymph node: 64.4737% (minimum 70%, Missing); retina: 41.8803% (minimum 75%, Missing); thymus: 54.4444% (minimum 65%, Missing)",-0.105556,-0.0552632,-0.331197,0,4,partial,6.8,2.7,4.1,"retina: 6.8 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197275,RAD54B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 71.0145% (minimum 75%, Missing); choroid plexus: 67.1233% (minimum 75%, Missing); lymph node: 64.4737% (minimum 70%, Missing); retina: 41.8803% (minimum 75%, Missing); thymus: 54.4444% (minimum 65%, Missing)",-0.105556,-0.0552632,-0.331197,0,4,partial,6.8,2.7,4.1,"retina: 6.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197275,RAD54B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 71.0145% (minimum 75%, Missing); choroid plexus: 67.1233% (minimum 75%, Missing); lymph node: 64.4737% (minimum 70%, Missing); retina: 41.8803% (minimum 75%, Missing); thymus: 54.4444% (minimum 65%, Missing)",-0.105556,-0.0552632,-0.331197,0,4,partial,6.8,2.7,4.1,"retina: 6.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197275,RAD54B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 71.0145% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.1233% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.4737% (minimum 70%, Baseline (adaptation disabled)); retina: 41.8803% (minimum 75%, Baseline (adaptation disabled)); thymus: 54.4444% (minimum 65%, Baseline (adaptation disabled))",-0.105556,-0.0552632,-0.331197,0,4,partial,6.8,2.7,4.1,"retina: 6.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197275,RAD54B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.4824% (minimum 99%, Missing); amygdala: 96.9697% (minimum 99%, Missing); basal ganglia: 96.0000% (minimum 99%, Missing); bone marrow: 91.8660% (minimum 99%, Missing); cerebellum: 96.9697% (minimum 99%, Missing); cerebral cortex: 96.4824% (minimum 99%, Missing); choroid plexus: 79.6680% (minimum 99%, Missing); colon: 86.4865% (minimum 97%, Missing); duodenum: 86.8778% (minimum 99%, Missing); esophagus: 89.7196% (minimum 97%, Missing); heart muscle: 96.4824% (minimum 99%, Missing); hippocampal formation: 96.9697% (minimum 99%, Missing); hypothalamus: 95.5224% (minimum 99%, Missing); kidney: 81.3559% (minimum 99%, Missing); liver: 88.8889% (minimum 99%, Missing); lung: 88.4793% (minimum 99%, Missing); lymph node: 92.3077% (minimum 97%, Missing); midbrain: 96.9697% (minimum 99%, Missing); pancreas: 80.6723% (minimum 99%, Missing); parathyroid gland: 75.5906% (minimum 97%, Missing); pituitary gland: 83.8428% (minimum 99%, Missing); rectum: 81.7021% (minimum 97%, Missing); retina: 89.7196% (minimum 99%, Missing); salivary gland: 90.9953% (minimum 97%, Missing); skeletal muscle: 95.5224% (minimum 99%, Missing); skin: 93.6585% (minimum 95%, Missing); small intestine: 89.3023% (minimum 99%, Missing); smooth muscle: 96.4824% (minimum 99%, Missing); spinal cord: 97.9592% (minimum 99%, Missing); spleen: 94.1176% (minimum 95%, Missing); stomach: 85.7143% (minimum 97%, Missing); thyroid gland: 83.1169% (minimum 95%, Missing); urinary bladder: 85.3333% (minimum 97%, Missing)",-0.118831,-0.214094,-0.19332,0,80,unavailable,4.9,6.2,3.9,"parathyroid gland: 6.2 nTPM (protected, limit 2); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); pituitary gland: 3.7 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); colon: 3 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197279,ZNF165,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.181169,0.0559055,0.0466805,0,80,unavailable,4.9,6.2,3.9,"parathyroid gland: 6.2 nTPM (protected, limit 2); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); pituitary gland: 3.7 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); colon: 3 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197279,ZNF165,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.181169,0.0559055,0.0466805,0,80,unavailable,4.9,6.2,3.9,"parathyroid gland: 6.2 nTPM (protected, limit 3); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); pituitary gland: 3.7 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197279,ZNF165,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.181169,0.0559055,0.0466805,0,80,unavailable,4.9,6.2,3.9,"parathyroid gland: 6.2 nTPM (protected, limit 3); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); pituitary gland: 3.7 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197279,ZNF165,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.181169,0.0559055,0.0466805,0,80,unavailable,4.9,6.2,3.9,"parathyroid gland: 6.2 nTPM (protected, limit 3); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); pituitary gland: 3.7 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197279,ZNF165,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197309,OR10D3,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197309,OR10D3,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197309,OR10D3,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197309,OR10D3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197309,OR10D3,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.2500% (minimum 95%, Missing); adrenal gland: 55.5985% (minimum 99%, Missing); amygdala: 63.7168% (minimum 99%, Missing); basal ganglia: 65.4545% (minimum 99%, Missing); bone marrow: 62.0690% (minimum 99%, Missing); cerebellum: 63.4361% (minimum 99%, Missing); cerebral cortex: 55.1724% (minimum 99%, Missing); choroid plexus: 58.5366% (minimum 99%, Missing); colon: 48.9796% (minimum 97%, Missing); duodenum: 48.4848% (minimum 99%, Missing); esophagus: 35.4680% (minimum 97%, Missing); heart muscle: 64.0000% (minimum 99%, Missing); hippocampal formation: 63.7168% (minimum 99%, Missing); hypothalamus: 63.1579% (minimum 99%, Missing); kidney: 51.9856% (minimum 99%, Missing); liver: 50.0000% (minimum 99%, Uncertain); lung: 49.3151% (minimum 99%, Missing); lymph node: 42.8571% (minimum 97%, Missing); midbrain: 57.6000% (minimum 99%, Missing); pancreas: 41.2607% (minimum 99%, Missing); parathyroid gland: 50.8834% (minimum 97%, Uncertain); pituitary gland: 64.2857% (minimum 99%, Missing); rectum: 55.8140% (minimum 97%, Missing); retina: 63.7168% (minimum 99%, Missing); salivary gland: 47.0588% (minimum 97%, Missing); skeletal muscle: 54.1353% (minimum 99%, Missing); skin: 44.5820% (minimum 95%, Missing); small intestine: 51.6129% (minimum 99%, Missing); smooth muscle: 56.0311% (minimum 99%, Missing); spinal cord: 51.6129% (minimum 99%, Missing); spleen: 51.0638% (minimum 95%, Missing); stomach: 45.1411% (minimum 97%, Missing); thymus: 39.5604% (minimum 95%, Missing); thyroid gland: 55.5985% (minimum 95%, Missing); tongue: 52.5547% (minimum 97%, Missing); urinary bladder: 44.3077% (minimum 97%, Missing)",-0.554396,-0.61532,-0.577393,0,2,partial,20.5,26.2,22,"esophagus: 26.2 nTPM (protected, limit 2); thymus: 22 nTPM (manageable, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 2); urinary bladder: 18.1 nTPM (protected, limit 2); skin: 17.9 nTPM (manageable, limit 5); stomach: 17.5 nTPM (protected, limit 2); salivary gland: 16.2 nTPM (protected, limit 2); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 2); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 2); spleen: 13.8 nTPM (manageable, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 2); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); adrenal gland: 11.5 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); rectum: 11.4 nTPM (protected, limit 2); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197343,ZNF655,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.2500% (minimum 65%, Missing); adrenal gland: 55.5985% (minimum 75%, Missing); amygdala: 63.7168% (minimum 75%, Missing); basal ganglia: 65.4545% (minimum 75%, Missing); bone marrow: 62.0690% (minimum 75%, Missing); cerebellum: 63.4361% (minimum 75%, Missing); cerebral cortex: 55.1724% (minimum 75%, Missing); choroid plexus: 58.5366% (minimum 75%, Missing); colon: 48.9796% (minimum 70%, Missing); duodenum: 48.4848% (minimum 75%, Missing); esophagus: 35.4680% (minimum 70%, Missing); heart muscle: 64.0000% (minimum 75%, Missing); hippocampal formation: 63.7168% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); kidney: 51.9856% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Uncertain); lung: 49.3151% (minimum 75%, Missing); lymph node: 42.8571% (minimum 70%, Missing); midbrain: 57.6000% (minimum 75%, Missing); pancreas: 41.2607% (minimum 75%, Missing); parathyroid gland: 50.8834% (minimum 70%, Uncertain); pituitary gland: 64.2857% (minimum 75%, Missing); rectum: 55.8140% (minimum 70%, Missing); retina: 63.7168% (minimum 75%, Missing); salivary gland: 47.0588% (minimum 70%, Missing); skeletal muscle: 54.1353% (minimum 75%, Missing); skin: 44.5820% (minimum 65%, Missing); small intestine: 51.6129% (minimum 75%, Missing); smooth muscle: 56.0311% (minimum 75%, Missing); spinal cord: 51.6129% (minimum 75%, Missing); spleen: 51.0638% (minimum 65%, Missing); stomach: 45.1411% (minimum 70%, Missing); thymus: 39.5604% (minimum 65%, Missing); thyroid gland: 55.5985% (minimum 65%, Missing); tongue: 52.5547% (minimum 70%, Missing); urinary bladder: 44.3077% (minimum 70%, Missing)",-0.254396,-0.34532,-0.337393,0,2,partial,20.5,26.2,22,"esophagus: 26.2 nTPM (protected, limit 2); thymus: 22 nTPM (manageable, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 2); urinary bladder: 18.1 nTPM (protected, limit 2); skin: 17.9 nTPM (manageable, limit 5); stomach: 17.5 nTPM (protected, limit 2); salivary gland: 16.2 nTPM (protected, limit 2); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 2); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 2); spleen: 13.8 nTPM (manageable, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 2); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); adrenal gland: 11.5 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); rectum: 11.4 nTPM (protected, limit 2); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197343,ZNF655,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.2500% (minimum 65%, Missing); adrenal gland: 55.5985% (minimum 75%, Missing); amygdala: 63.7168% (minimum 75%, Missing); basal ganglia: 65.4545% (minimum 75%, Missing); bone marrow: 62.0690% (minimum 75%, Missing); cerebellum: 63.4361% (minimum 75%, Missing); cerebral cortex: 55.1724% (minimum 75%, Missing); choroid plexus: 58.5366% (minimum 75%, Missing); colon: 48.9796% (minimum 70%, Missing); duodenum: 48.4848% (minimum 75%, Missing); esophagus: 35.4680% (minimum 70%, Missing); heart muscle: 64.0000% (minimum 75%, Missing); hippocampal formation: 63.7168% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); kidney: 51.9856% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Uncertain); lung: 49.3151% (minimum 75%, Missing); lymph node: 42.8571% (minimum 70%, Missing); midbrain: 57.6000% (minimum 75%, Missing); pancreas: 41.2607% (minimum 75%, Missing); parathyroid gland: 50.8834% (minimum 70%, Uncertain); pituitary gland: 64.2857% (minimum 75%, Missing); rectum: 55.8140% (minimum 70%, Missing); retina: 63.7168% (minimum 75%, Missing); salivary gland: 47.0588% (minimum 70%, Missing); skeletal muscle: 54.1353% (minimum 75%, Missing); skin: 44.5820% (minimum 65%, Missing); small intestine: 51.6129% (minimum 75%, Missing); smooth muscle: 56.0311% (minimum 75%, Missing); spinal cord: 51.6129% (minimum 75%, Missing); spleen: 51.0638% (minimum 65%, Missing); stomach: 45.1411% (minimum 70%, Missing); thymus: 39.5604% (minimum 65%, Missing); thyroid gland: 55.5985% (minimum 65%, Missing); tongue: 52.5547% (minimum 70%, Missing); urinary bladder: 44.3077% (minimum 70%, Missing)",-0.254396,-0.34532,-0.337393,0,2,partial,20.5,26.2,22,"esophagus: 26.2 nTPM (protected, limit 3); thymus: 22 nTPM (manageable, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 3); urinary bladder: 18.1 nTPM (protected, limit 3); skin: 17.9 nTPM (manageable, limit 5); stomach: 17.5 nTPM (protected, limit 3); salivary gland: 16.2 nTPM (protected, limit 3); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 3); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 3); spleen: 13.8 nTPM (manageable, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 3); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); adrenal gland: 11.5 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); rectum: 11.4 nTPM (protected, limit 3); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197343,ZNF655,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.2500% (minimum 65%, Missing); adrenal gland: 55.5985% (minimum 75%, Missing); amygdala: 63.7168% (minimum 75%, Missing); basal ganglia: 65.4545% (minimum 75%, Missing); bone marrow: 62.0690% (minimum 75%, Missing); cerebellum: 63.4361% (minimum 75%, Missing); cerebral cortex: 55.1724% (minimum 75%, Missing); choroid plexus: 58.5366% (minimum 75%, Missing); colon: 48.9796% (minimum 70%, Missing); duodenum: 48.4848% (minimum 75%, Missing); esophagus: 35.4680% (minimum 70%, Missing); heart muscle: 64.0000% (minimum 75%, Missing); hippocampal formation: 63.7168% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); kidney: 51.9856% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Uncertain); lung: 49.3151% (minimum 75%, Missing); lymph node: 42.8571% (minimum 70%, Missing); midbrain: 57.6000% (minimum 75%, Missing); pancreas: 41.2607% (minimum 75%, Missing); parathyroid gland: 50.8834% (minimum 70%, Uncertain); pituitary gland: 64.2857% (minimum 75%, Missing); rectum: 55.8140% (minimum 70%, Missing); retina: 63.7168% (minimum 75%, Missing); salivary gland: 47.0588% (minimum 70%, Missing); skeletal muscle: 54.1353% (minimum 75%, Missing); skin: 44.5820% (minimum 65%, Missing); small intestine: 51.6129% (minimum 75%, Missing); smooth muscle: 56.0311% (minimum 75%, Missing); spinal cord: 51.6129% (minimum 75%, Missing); spleen: 51.0638% (minimum 65%, Missing); stomach: 45.1411% (minimum 70%, Missing); thymus: 39.5604% (minimum 65%, Missing); thyroid gland: 55.5985% (minimum 65%, Missing); tongue: 52.5547% (minimum 70%, Missing); urinary bladder: 44.3077% (minimum 70%, Missing)",-0.254396,-0.34532,-0.337393,0,2,partial,20.5,26.2,22,"esophagus: 26.2 nTPM (protected, limit 3); thymus: 22 nTPM (manageable, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 3); urinary bladder: 18.1 nTPM (protected, limit 3); skin: 17.9 nTPM (manageable, limit 5); stomach: 17.5 nTPM (protected, limit 3); salivary gland: 16.2 nTPM (protected, limit 3); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 3); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 3); spleen: 13.8 nTPM (manageable, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 3); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); adrenal gland: 11.5 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); rectum: 11.4 nTPM (protected, limit 3); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197343,ZNF655,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.2500% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 55.5985% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.7168% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.4545% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 62.0690% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 63.4361% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 55.1724% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.5366% (minimum 75%, Baseline (adaptation disabled)); colon: 48.9796% (minimum 70%, Baseline (adaptation disabled)); duodenum: 48.4848% (minimum 75%, Baseline (adaptation disabled)); esophagus: 35.4680% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.7168% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.1579% (minimum 75%, Baseline (adaptation disabled)); kidney: 51.9856% (minimum 75%, Baseline (adaptation disabled)); liver: 50.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 49.3151% (minimum 75%, Baseline (adaptation disabled)); lymph node: 42.8571% (minimum 70%, Baseline (adaptation disabled)); midbrain: 57.6000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 41.2607% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.8834% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 64.2857% (minimum 75%, Baseline (adaptation disabled)); rectum: 55.8140% (minimum 70%, Baseline (adaptation disabled)); retina: 63.7168% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 47.0588% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 54.1353% (minimum 75%, Baseline (adaptation disabled)); skin: 44.5820% (minimum 65%, Baseline (adaptation disabled)); small intestine: 51.6129% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.0311% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 51.6129% (minimum 75%, Baseline (adaptation disabled)); spleen: 51.0638% (minimum 65%, Baseline (adaptation disabled)); stomach: 45.1411% (minimum 70%, Baseline (adaptation disabled)); thymus: 39.5604% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.5985% (minimum 65%, Baseline (adaptation disabled)); tongue: 52.5547% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 44.3077% (minimum 70%, Baseline (adaptation disabled))",-0.254396,-0.34532,-0.337393,0,2,partial,20.5,26.2,22,"esophagus: 26.2 nTPM (protected, limit 3); thymus: 22 nTPM (manageable, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 3); urinary bladder: 18.1 nTPM (protected, limit 3); skin: 17.9 nTPM (manageable, limit 5); stomach: 17.5 nTPM (protected, limit 3); salivary gland: 16.2 nTPM (protected, limit 3); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 3); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 3); spleen: 13.8 nTPM (manageable, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 3); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); adrenal gland: 11.5 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); rectum: 11.4 nTPM (protected, limit 3); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197343,ZNF655,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.0990% (minimum 95%, Missing); adrenal gland: 94.7917% (minimum 99%, Missing); amygdala: 90.0990% (minimum 99%, Missing); basal ganglia: 64.5390% (minimum 99%, Missing); bone marrow: 97.8495% (minimum 99%, Missing); cerebellum: 97.8495% (minimum 99%, Missing); cerebral cortex: 73.9837% (minimum 99%, Missing); choroid plexus: 98.9130% (minimum 99%, Missing); duodenum: 98.9130% (minimum 99%, Missing); heart muscle: 93.8144% (minimum 99%, Missing); hippocampal formation: 89.2157% (minimum 99%, Missing); hypothalamus: 93.8144% (minimum 99%, Missing); kidney: 81.9820% (minimum 99%, Missing); lung: 97.8495% (minimum 99%, Missing); lymph node: 95.7895% (minimum 97%, Missing); midbrain: 89.2157% (minimum 99%, Missing); pancreas: 20.2222% (minimum 99%, Missing); parathyroid gland: 71.0937% (minimum 97%, Missing); pituitary gland: 96.8085% (minimum 99%, Missing); retina: 93.8144% (minimum 99%, Missing); salivary gland: 91.9192% (minimum 97%, Missing); small intestine: 98.9130% (minimum 99%, Missing); smooth muscle: 88.3495% (minimum 99%, Missing); spinal cord: 95.7895% (minimum 99%, Missing); stomach: 96.8085% (minimum 97%, Missing); thyroid gland: 66.9118% (minimum 95%, Missing); urinary bladder: 94.7917% (minimum 97%, Missing)",-0.280882,-0.259063,-0.787778,0,80,unavailable,35.9,3.7,4.5,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197360,ZNF98,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 64.5390% (minimum 75%, Missing); cerebral cortex: 73.9837% (minimum 75%, Missing); pancreas: 20.2222% (minimum 75%, Missing)",0.0191176,0.0109375,-0.547778,0,80,unavailable,35.9,3.7,4.5,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197360,ZNF98,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 64.5390% (minimum 75%, Missing); cerebral cortex: 73.9837% (minimum 75%, Missing); pancreas: 20.2222% (minimum 75%, Missing)",0.0191176,0.0109375,-0.547778,0,80,unavailable,35.9,3.7,4.5,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197360,ZNF98,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 64.5390% (minimum 75%, Missing); cerebral cortex: 73.9837% (minimum 75%, Missing); pancreas: 20.2222% (minimum 75%, Missing)",0.0191176,0.0109375,-0.547778,0,80,unavailable,35.9,3.7,4.5,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197360,ZNF98,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 64.5390% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.9837% (minimum 75%, Baseline (adaptation disabled)); pancreas: 20.2222% (minimum 75%, Baseline (adaptation disabled))",0.0191176,0.0109375,-0.547778,0,80,unavailable,35.9,3.7,4.5,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197360,ZNF98,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.3564% (minimum 95%, Missing); adrenal gland: 71.0383% (minimum 99%, Missing); amygdala: 73.0337% (minimum 99%, Missing); basal ganglia: 75.1445% (minimum 99%, Missing); bone marrow: 53.7190% (minimum 99%, Missing); cerebellum: 72.2222% (minimum 99%, Missing); cerebral cortex: 54.8523% (minimum 99%, Missing); choroid plexus: 77.3810% (minimum 99%, Missing); colon: 61.9048% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 69.1489% (minimum 97%, Missing); heart muscle: 80.2469% (minimum 99%, Missing); hippocampal formation: 71.4286% (minimum 99%, Missing); hypothalamus: 73.8636% (minimum 99%, Missing); kidney: 72.2222% (minimum 99%, Missing); liver: 67.3575% (minimum 99%, Missing); lung: 66.3265% (minimum 99%, Missing); lymph node: 50.7812% (minimum 97%, Missing); midbrain: 77.8443% (minimum 99%, Missing); pancreas: 63.7255% (minimum 99%, Missing); parathyroid gland: 64.3564% (minimum 97%, Missing); pituitary gland: 87.2483% (minimum 99%, Missing); rectum: 52.4194% (minimum 97%, Missing); retina: 55.7940% (minimum 99%, Missing); salivary gland: 66.3265% (minimum 97%, Missing); skeletal muscle: 79.7546% (minimum 99%, Missing); skin: 57.7778% (minimum 95%, Missing); small intestine: 69.1489% (minimum 99%, Missing); smooth muscle: 76.4706% (minimum 99%, Missing); spinal cord: 75.1445% (minimum 99%, Missing); spleen: 58.5586% (minimum 95%, Missing); stomach: 59.6330% (minimum 97%, Missing); thymus: 56.0345% (minimum 95%, Missing); thyroid gland: 61.0329% (minimum 95%, Missing); tongue: 78.7879% (minimum 97%, Missing); urinary bladder: 71.0383% (minimum 97%, Missing)",-0.389655,-0.462187,-0.45281,0,80,unavailable,11.2,12.6,10.2,"lymph node: 12.6 nTPM (protected, limit 2); rectum: 11.8 nTPM (protected, limit 2); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); skin: 9.5 nTPM (manageable, limit 5); spleen: 9.2 nTPM (manageable, limit 5); stomach: 8.8 nTPM (protected, limit 2); thyroid gland: 8.3 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 2); pancreas: 7.4 nTPM (vital, limit 1); adipose tissue: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); esophagus: 5.8 nTPM (protected, limit 2); urinary bladder: 5.3 nTPM (protected, limit 2); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197372,ZNF675,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.3564% (minimum 65%, Missing); adrenal gland: 71.0383% (minimum 75%, Missing); amygdala: 73.0337% (minimum 75%, Missing); bone marrow: 53.7190% (minimum 75%, Missing); cerebellum: 72.2222% (minimum 75%, Missing); cerebral cortex: 54.8523% (minimum 75%, Missing); colon: 61.9048% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 69.1489% (minimum 70%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 73.8636% (minimum 75%, Missing); kidney: 72.2222% (minimum 75%, Missing); liver: 67.3575% (minimum 75%, Missing); lung: 66.3265% (minimum 75%, Missing); lymph node: 50.7812% (minimum 70%, Missing); pancreas: 63.7255% (minimum 75%, Missing); parathyroid gland: 64.3564% (minimum 70%, Missing); rectum: 52.4194% (minimum 70%, Missing); retina: 55.7940% (minimum 75%, Missing); salivary gland: 66.3265% (minimum 70%, Missing); skin: 57.7778% (minimum 65%, Missing); small intestine: 69.1489% (minimum 75%, Missing); spleen: 58.5586% (minimum 65%, Missing); stomach: 59.6330% (minimum 70%, Missing); thymus: 56.0345% (minimum 65%, Missing); thyroid gland: 61.0329% (minimum 65%, Missing)",-0.0896552,-0.192187,-0.21281,0,80,unavailable,11.2,12.6,10.2,"lymph node: 12.6 nTPM (protected, limit 2); rectum: 11.8 nTPM (protected, limit 2); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); skin: 9.5 nTPM (manageable, limit 5); spleen: 9.2 nTPM (manageable, limit 5); stomach: 8.8 nTPM (protected, limit 2); thyroid gland: 8.3 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 2); pancreas: 7.4 nTPM (vital, limit 1); adipose tissue: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); esophagus: 5.8 nTPM (protected, limit 2); urinary bladder: 5.3 nTPM (protected, limit 2); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197372,ZNF675,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.3564% (minimum 65%, Missing); adrenal gland: 71.0383% (minimum 75%, Missing); amygdala: 73.0337% (minimum 75%, Missing); bone marrow: 53.7190% (minimum 75%, Missing); cerebellum: 72.2222% (minimum 75%, Missing); cerebral cortex: 54.8523% (minimum 75%, Missing); colon: 61.9048% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 69.1489% (minimum 70%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 73.8636% (minimum 75%, Missing); kidney: 72.2222% (minimum 75%, Missing); liver: 67.3575% (minimum 75%, Missing); lung: 66.3265% (minimum 75%, Missing); lymph node: 50.7812% (minimum 70%, Missing); pancreas: 63.7255% (minimum 75%, Missing); parathyroid gland: 64.3564% (minimum 70%, Missing); rectum: 52.4194% (minimum 70%, Missing); retina: 55.7940% (minimum 75%, Missing); salivary gland: 66.3265% (minimum 70%, Missing); skin: 57.7778% (minimum 65%, Missing); small intestine: 69.1489% (minimum 75%, Missing); spleen: 58.5586% (minimum 65%, Missing); stomach: 59.6330% (minimum 70%, Missing); thymus: 56.0345% (minimum 65%, Missing); thyroid gland: 61.0329% (minimum 65%, Missing)",-0.0896552,-0.192187,-0.21281,0,80,unavailable,11.2,12.6,10.2,"lymph node: 12.6 nTPM (protected, limit 3); rectum: 11.8 nTPM (protected, limit 3); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); skin: 9.5 nTPM (manageable, limit 5); spleen: 9.2 nTPM (manageable, limit 5); stomach: 8.8 nTPM (protected, limit 3); thyroid gland: 8.3 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 3); pancreas: 7.4 nTPM (vital, limit 1); adipose tissue: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); esophagus: 5.8 nTPM (protected, limit 3); urinary bladder: 5.3 nTPM (protected, limit 3); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197372,ZNF675,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.3564% (minimum 65%, Missing); adrenal gland: 71.0383% (minimum 75%, Missing); amygdala: 73.0337% (minimum 75%, Missing); bone marrow: 53.7190% (minimum 75%, Missing); cerebellum: 72.2222% (minimum 75%, Missing); cerebral cortex: 54.8523% (minimum 75%, Missing); colon: 61.9048% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 69.1489% (minimum 70%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 73.8636% (minimum 75%, Missing); kidney: 72.2222% (minimum 75%, Missing); liver: 67.3575% (minimum 75%, Missing); lung: 66.3265% (minimum 75%, Missing); lymph node: 50.7812% (minimum 70%, Missing); pancreas: 63.7255% (minimum 75%, Missing); parathyroid gland: 64.3564% (minimum 70%, Missing); rectum: 52.4194% (minimum 70%, Missing); retina: 55.7940% (minimum 75%, Missing); salivary gland: 66.3265% (minimum 70%, Missing); skin: 57.7778% (minimum 65%, Missing); small intestine: 69.1489% (minimum 75%, Missing); spleen: 58.5586% (minimum 65%, Missing); stomach: 59.6330% (minimum 70%, Missing); thymus: 56.0345% (minimum 65%, Missing); thyroid gland: 61.0329% (minimum 65%, Missing)",-0.0896552,-0.192187,-0.21281,0,80,unavailable,11.2,12.6,10.2,"lymph node: 12.6 nTPM (protected, limit 3); rectum: 11.8 nTPM (protected, limit 3); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); skin: 9.5 nTPM (manageable, limit 5); spleen: 9.2 nTPM (manageable, limit 5); stomach: 8.8 nTPM (protected, limit 3); thyroid gland: 8.3 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 3); pancreas: 7.4 nTPM (vital, limit 1); adipose tissue: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); esophagus: 5.8 nTPM (protected, limit 3); urinary bladder: 5.3 nTPM (protected, limit 3); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197372,ZNF675,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.3564% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 71.0383% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.0337% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 53.7190% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.2222% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 54.8523% (minimum 75%, Baseline (adaptation disabled)); colon: 61.9048% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.1489% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 71.4286% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.8636% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.2222% (minimum 75%, Baseline (adaptation disabled)); liver: 67.3575% (minimum 75%, Baseline (adaptation disabled)); lung: 66.3265% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.7812% (minimum 70%, Baseline (adaptation disabled)); pancreas: 63.7255% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.3564% (minimum 70%, Baseline (adaptation disabled)); rectum: 52.4194% (minimum 70%, Baseline (adaptation disabled)); retina: 55.7940% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.3265% (minimum 70%, Baseline (adaptation disabled)); skin: 57.7778% (minimum 65%, Baseline (adaptation disabled)); small intestine: 69.1489% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.5586% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.6330% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.0345% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 61.0329% (minimum 65%, Baseline (adaptation disabled))",-0.0896552,-0.192187,-0.21281,0,80,unavailable,11.2,12.6,10.2,"lymph node: 12.6 nTPM (protected, limit 3); rectum: 11.8 nTPM (protected, limit 3); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); skin: 9.5 nTPM (manageable, limit 5); spleen: 9.2 nTPM (manageable, limit 5); stomach: 8.8 nTPM (protected, limit 3); thyroid gland: 8.3 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 3); pancreas: 7.4 nTPM (vital, limit 1); adipose tissue: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); esophagus: 5.8 nTPM (protected, limit 3); urinary bladder: 5.3 nTPM (protected, limit 3); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197372,ZNF675,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.8571% (minimum 99%, Missing); amygdala: 72.2222% (minimum 99%, Missing); basal ganglia: 37.1429% (minimum 99%, Missing); cerebellum: 92.8571% (minimum 99%, Missing); cerebral cortex: 43.3333% (minimum 99%, Missing); colon: 43.3333% (minimum 97%, Missing); hippocampal formation: 68.4211% (minimum 99%, Missing); hypothalamus: 61.9048% (minimum 99%, Missing); kidney: 92.8571% (minimum 99%, Missing); lung: 92.8571% (minimum 99%, Missing); midbrain: 68.4211% (minimum 99%, Missing); pituitary gland: 72.2222% (minimum 99%, Missing); retina: 92.8571% (minimum 99%, Missing); salivary gland: 92.8571% (minimum 97%, Missing); skin: 86.6667% (minimum 95%, Missing); small intestine: 81.2500% (minimum 99%, Missing); smooth muscle: 92.8571% (minimum 99%, Missing); spinal cord: 76.4706% (minimum 99%, Missing); stomach: 52.0000% (minimum 97%, Missing); urinary bladder: 68.4211% (minimum 97%, Missing)",-0.0833333,-0.536667,-0.618571,0,80,unavailable,2.2,1.7,0.2,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197410,DCHS2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 37.1429% (minimum 75%, Missing); cerebral cortex: 43.3333% (minimum 75%, Missing); colon: 43.3333% (minimum 70%, Missing); hippocampal formation: 68.4211% (minimum 75%, Missing); hypothalamus: 61.9048% (minimum 75%, Missing); midbrain: 68.4211% (minimum 75%, Missing); pituitary gland: 72.2222% (minimum 75%, Missing); stomach: 52.0000% (minimum 70%, Missing); urinary bladder: 68.4211% (minimum 70%, Missing)",0.216667,-0.266667,-0.378571,0,80,unavailable,2.2,1.7,0.2,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197410,DCHS2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 37.1429% (minimum 75%, Missing); cerebral cortex: 43.3333% (minimum 75%, Missing); colon: 43.3333% (minimum 70%, Missing); hippocampal formation: 68.4211% (minimum 75%, Missing); hypothalamus: 61.9048% (minimum 75%, Missing); midbrain: 68.4211% (minimum 75%, Missing); pituitary gland: 72.2222% (minimum 75%, Missing); stomach: 52.0000% (minimum 70%, Missing); urinary bladder: 68.4211% (minimum 70%, Missing)",0.216667,-0.266667,-0.378571,0,80,unavailable,2.2,1.7,0.2,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197410,DCHS2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 37.1429% (minimum 75%, Missing); cerebral cortex: 43.3333% (minimum 75%, Missing); colon: 43.3333% (minimum 70%, Missing); hippocampal formation: 68.4211% (minimum 75%, Missing); hypothalamus: 61.9048% (minimum 75%, Missing); midbrain: 68.4211% (minimum 75%, Missing); pituitary gland: 72.2222% (minimum 75%, Missing); stomach: 52.0000% (minimum 70%, Missing); urinary bladder: 68.4211% (minimum 70%, Missing)",0.216667,-0.266667,-0.378571,0,80,unavailable,2.2,1.7,0.2,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197410,DCHS2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.2222% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 37.1429% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 43.3333% (minimum 75%, Baseline (adaptation disabled)); colon: 43.3333% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 68.4211% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.9048% (minimum 75%, Baseline (adaptation disabled)); midbrain: 68.4211% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 72.2222% (minimum 75%, Baseline (adaptation disabled)); stomach: 52.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 68.4211% (minimum 70%, Baseline (adaptation disabled))",0.216667,-0.266667,-0.378571,0,80,unavailable,2.2,1.7,0.2,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197410,DCHS2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 98.6301% (minimum 99%, Missing); duodenum: 94.7368% (minimum 95%, Enhanced); esophagus: 75.0000% (minimum 80%, Enhanced); pituitary gland: 94.7368% (minimum 99%, Missing); retina: 11.6694% (minimum 99%, Missing)",0.05,-0.05,-0.873306,0,3,partial,54.5,2.4,0,"retina: 54.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197416,FABP12,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 11.6694% (minimum 75%, Missing)",0.35,0.2,-0.633306,0,3,partial,54.5,2.4,0,"retina: 54.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197416,FABP12,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 11.6694% (minimum 75%, Missing)",0.35,0.2,-0.633306,0,3,partial,54.5,2.4,0,"retina: 54.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197416,FABP12,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 11.6694% (minimum 75%, Missing)",0.35,0.2,-0.633306,0,3,partial,54.5,2.4,0,"retina: 54.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197416,FABP12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 11.6694% (minimum 75%, Baseline (adaptation disabled))",0.35,0.05,-0.633306,0,3,partial,54.5,2.4,0,"retina: 54.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197416,FABP12,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197437,OR13G1,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197437,OR13G1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197437,OR13G1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197437,OR13G1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197437,OR13G1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 84.2105% (minimum 97%, Supported); amygdala: 87.2727% (minimum 99%, Missing); basal ganglia: 83.4783% (minimum 99%, Missing); bone marrow: 96.0000% (minimum 97%, Supported); cerebellum: 93.2039% (minimum 97%, Supported); cerebral cortex: 77.4194% (minimum 97%, Supported); choroid plexus: 75.5906% (minimum 99%, Missing); colon: 79.3388% (minimum 97%, Missing); duodenum: 85.7143% (minimum 99%, Missing); esophagus: 86.4865% (minimum 90%, Supported); heart muscle: 75.0000% (minimum 97%, Supported); hippocampal formation: 88.0734% (minimum 99%, Missing); hypothalamus: 86.4865% (minimum 99%, Missing); kidney: 66.6667% (minimum 97%, Supported); liver: 77.4194% (minimum 97%, Supported); lung: 79.3388% (minimum 97%, Supported); lymph node: 88.8889% (minimum 90%, Supported); midbrain: 87.2727% (minimum 99%, Missing); pancreas: 75.0000% (minimum 97%, Supported); parathyroid gland: 63.5762% (minimum 90%, Supported); pituitary gland: 82.7586% (minimum 99%, Missing); rectum: 80.0000% (minimum 97%, Missing); retina: 54.5455% (minimum 99%, Missing); salivary gland: 75.5906% (minimum 90%, Supported); skeletal muscle: 86.4865% (minimum 97%, Supported); small intestine: 85.7143% (minimum 99%, Missing); smooth muscle: 78.6885% (minimum 97%, Supported); spinal cord: 89.7196% (minimum 99%, Missing); stomach: 78.0488% (minimum 90%, Supported); thymus: 85.7143% (minimum 95%, Missing); thyroid gland: 58.1818% (minimum 80%, Supported); tongue: 88.8889% (minimum 97%, Missing); urinary bladder: 88.8889% (minimum 90%, Supported)",-0.218182,-0.264238,-0.444545,0,8,partial,8,5.5,6.9,"retina: 8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 3); heart muscle: 3.2 nTPM (vital, limit 3); pancreas: 3.2 nTPM (vital, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197557,IFT70A,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 54.5455% (minimum 75%, Missing)",0.0318182,0.0357616,-0.204545,0,8,partial,8,5.5,6.9,"retina: 8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 3); heart muscle: 3.2 nTPM (vital, limit 3); pancreas: 3.2 nTPM (vital, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197557,IFT70A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 54.5455% (minimum 75%, Missing)",0.0318182,0.0357616,-0.204545,0,8,partial,8,5.5,6.9,"retina: 8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 3); heart muscle: 3.2 nTPM (vital, limit 3); pancreas: 3.2 nTPM (vital, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197557,IFT70A,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 54.5455% (minimum 75%, Missing)",0.0318182,0.0357616,-0.204545,0,8,partial,8,5.5,6.9,"retina: 8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 3); heart muscle: 3.2 nTPM (vital, limit 3); pancreas: 3.2 nTPM (vital, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197557,IFT70A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"heart muscle: 75.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.5762% (minimum 70%, Baseline (adaptation disabled)); retina: 54.5455% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 58.1818% (minimum 65%, Baseline (adaptation disabled))",-0.0681818,-0.0642384,-0.204545,0,8,partial,8,5.5,6.9,"retina: 8 nTPM (vital, limit 1); thyroid gland: 6.9 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 3); kidney: 4.8 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.8 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197557,IFT70A,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.6032% (minimum 95%, Missing); adrenal gland: 87.0370% (minimum 99%, Missing); amygdala: 82.4561% (minimum 99%, Missing); basal ganglia: 82.4561% (minimum 99%, Missing); bone marrow: 81.0345% (minimum 99%, Missing); cerebellum: 85.4545% (minimum 99%, Missing); cerebral cortex: 72.3077% (minimum 99%, Missing); choroid plexus: 94.0000% (minimum 99%, Missing); colon: 73.4375% (minimum 97%, Missing); duodenum: 78.3333% (minimum 99%, Missing); esophagus: 79.6610% (minimum 97%, Missing); heart muscle: 77.0492% (minimum 99%, Missing); hippocampal formation: 82.4561% (minimum 99%, Missing); hypothalamus: 83.9286% (minimum 99%, Missing); kidney: 72.3077% (minimum 99%, Missing); liver: 85.4545% (minimum 99%, Missing); lung: 71.2121% (minimum 99%, Missing); lymph node: 66.1972% (minimum 97%, Missing); midbrain: 81.0345% (minimum 99%, Missing); pancreas: 85.4545% (minimum 99%, Missing); parathyroid gland: 66.1972% (minimum 97%, Missing); pituitary gland: 92.1569% (minimum 99%, Missing); rectum: 73.4375% (minimum 97%, Missing); retina: 64.3836% (minimum 99%, Missing); salivary gland: 85.4545% (minimum 97%, Missing); skeletal muscle: 92.1569% (minimum 99%, Missing); skin: 75.8065% (minimum 95%, Missing); small intestine: 78.3333% (minimum 99%, Missing); smooth muscle: 71.2121% (minimum 99%, Missing); spinal cord: 73.4375% (minimum 99%, Missing); spleen: 58.0247% (minimum 95%, Missing); stomach: 72.3077% (minimum 97%, Missing); thymus: 61.0390% (minimum 95%, Missing); thyroid gland: 67.1429% (minimum 95%, Missing); tongue: 83.9286% (minimum 97%, Missing); urinary bladder: 78.3333% (minimum 97%, Missing)",-0.369753,-0.308028,-0.346164,0,1,partial,2.6,2.4,3.4,"retina: 2.6 nTPM (vital, limit 1); lymph node: 2.4 nTPM (protected, limit 2); parathyroid gland: 2.4 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197566,ZNF624,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 72.3077% (minimum 75%, Missing); kidney: 72.3077% (minimum 75%, Missing); lung: 71.2121% (minimum 75%, Missing); lymph node: 66.1972% (minimum 70%, Missing); parathyroid gland: 66.1972% (minimum 70%, Missing); retina: 64.3836% (minimum 75%, Missing); smooth muscle: 71.2121% (minimum 75%, Missing); spinal cord: 73.4375% (minimum 75%, Missing); spleen: 58.0247% (minimum 65%, Missing); thymus: 61.0390% (minimum 65%, Missing)",-0.0697531,-0.0380282,-0.106164,0,1,partial,2.6,2.4,3.4,"retina: 2.6 nTPM (vital, limit 1); lymph node: 2.4 nTPM (protected, limit 2); parathyroid gland: 2.4 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197566,ZNF624,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 72.3077% (minimum 75%, Missing); kidney: 72.3077% (minimum 75%, Missing); lung: 71.2121% (minimum 75%, Missing); lymph node: 66.1972% (minimum 70%, Missing); parathyroid gland: 66.1972% (minimum 70%, Missing); retina: 64.3836% (minimum 75%, Missing); smooth muscle: 71.2121% (minimum 75%, Missing); spinal cord: 73.4375% (minimum 75%, Missing); spleen: 58.0247% (minimum 65%, Missing); thymus: 61.0390% (minimum 65%, Missing)",-0.0697531,-0.0380282,-0.106164,0,1,partial,2.6,2.4,3.4,"retina: 2.6 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197566,ZNF624,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 72.3077% (minimum 75%, Missing); kidney: 72.3077% (minimum 75%, Missing); lung: 71.2121% (minimum 75%, Missing); lymph node: 66.1972% (minimum 70%, Missing); parathyroid gland: 66.1972% (minimum 70%, Missing); retina: 64.3836% (minimum 75%, Missing); smooth muscle: 71.2121% (minimum 75%, Missing); spinal cord: 73.4375% (minimum 75%, Missing); spleen: 58.0247% (minimum 65%, Missing); thymus: 61.0390% (minimum 65%, Missing)",-0.0697531,-0.0380282,-0.106164,0,1,partial,2.6,2.4,3.4,"retina: 2.6 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197566,ZNF624,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 72.3077% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.3077% (minimum 75%, Baseline (adaptation disabled)); lung: 71.2121% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.1972% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 66.1972% (minimum 70%, Baseline (adaptation disabled)); retina: 64.3836% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.2121% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.4375% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.0247% (minimum 65%, Baseline (adaptation disabled)); thymus: 61.0390% (minimum 65%, Baseline (adaptation disabled))",-0.0697531,-0.0380282,-0.106164,0,1,partial,2.6,2.4,3.4,"retina: 2.6 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197566,ZNF624,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.3418% (minimum 99%, Missing); amygdala: 90.3141% (minimum 99%, Missing); basal ganglia: 96.1003% (minimum 99%, Missing); cerebellum: 98.2906% (minimum 99%, Missing); cerebral cortex: 87.7863% (minimum 99%, Missing); colon: 96.9101% (minimum 97%, Missing); duodenum: 98.5714% (minimum 99%, Missing); heart muscle: 86.0349% (minimum 99%, Missing); hippocampal formation: 87.5635% (minimum 99%, Missing); hypothalamus: 92.9919% (minimum 99%, Missing); kidney: 91.2698% (minimum 99%, Missing); lung: 96.9101% (minimum 99%, Missing); midbrain: 93.4959% (minimum 99%, Missing); pancreas: 89.8438% (minimum 99%, Missing); pituitary gland: 95.8333% (minimum 99%, Missing); small intestine: 98.5714% (minimum 99%, Missing); smooth muscle: 95.0413% (minimum 99%, Uncertain); spinal cord: 95.3039% (minimum 99%, Missing); stomach: 92.2460% (minimum 97%, Missing)",0.0163866,-0.0475401,-0.129651,0,0,routine_complete,5.6,2.9,1.2,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197584,KCNMB2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.316387,0.22246,0.110349,0,0,routine_complete,5.6,2.9,1.2,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197584,KCNMB2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.316387,0.22246,0.110349,0,0,routine_complete,5.6,2.9,1.2,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197584,KCNMB2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.316387,0.22246,0.110349,0,0,routine_complete,5.6,2.9,1.2,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197584,KCNMB2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.316387,0.22246,0.110349,0,0,routine_complete,5.6,2.9,1.2,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197584,KCNMB2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 90.0000% (minimum 99%, Missing); choroid plexus: 90.0000% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); midbrain: 69.2308% (minimum 99%, Missing); parathyroid gland: 90.0000% (minimum 97%, Missing); pituitary gland: 60.0000% (minimum 99%, Missing); retina: 56.2500% (minimum 99%, Missing); skin: 90.0000% (minimum 95%, Missing); thyroid gland: 81.8182% (minimum 95%, Missing); urinary bladder: 81.8182% (minimum 97%, Missing)",-0.131818,-0.151818,-0.4275,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197587,DMBX1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 69.2308% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 56.2500% (minimum 75%, Missing)",0.168182,0.118182,-0.1875,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197587,DMBX1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 69.2308% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 56.2500% (minimum 75%, Missing)",0.168182,0.118182,-0.1875,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197587,DMBX1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 69.2308% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 56.2500% (minimum 75%, Missing)",0.168182,0.118182,-0.1875,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197587,DMBX1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 69.2308% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 56.2500% (minimum 75%, Baseline (adaptation disabled))",0.168182,0.118182,-0.1875,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197587,DMBX1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197617,VN1R5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197617,VN1R5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197617,VN1R5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197617,VN1R5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197617,VN1R5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197651,CCER1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197651,CCER1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197651,CCER1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197651,CCER1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197651,CCER1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.0233% (minimum 99%, Missing); basal ganglia: 85.1064% (minimum 99%, Missing); bone marrow: 76.9231% (minimum 95%, Enhanced); cerebellum: 86.9565% (minimum 95%, Enhanced); choroid plexus: 90.9091% (minimum 99%, Missing); hippocampal formation: 86.9565% (minimum 99%, Missing); hypothalamus: 85.1064% (minimum 99%, Missing); kidney: 97.5610% (minimum 99%, Missing); lung: 78.4314% (minimum 95%, Enhanced); midbrain: 95.2381% (minimum 99%, Missing); pituitary gland: 97.5610% (minimum 99%, Missing); retina: 95.2381% (minimum 99%, Missing); small intestine: 93.0233% (minimum 95%, Enhanced); spinal cord: 85.1064% (minimum 99%, Missing)",0.05,0.03,-0.180769,0,6,partial,1.2,0.1,0.1,,adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197653,DNAH10,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.101064,0,6,partial,1.2,0.1,0.1,,adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197653,DNAH10,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.101064,0,6,partial,1.2,0.1,0.1,,adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197653,DNAH10,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.101064,0,6,partial,1.2,0.1,0.1,,adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197653,DNAH10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.32561,0.27561,0.0192308,0,6,partial,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197653,DNAH10,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 76.4706% (minimum 95%, Missing); skin: 6.5000% (minimum 95%, Missing)",-0.885,0.03,0.01,0,80,unavailable,0,0,18.7,"skin: 18.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197683,KRTAP26-1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"skin: 6.5000% (minimum 65%, Missing)",-0.585,0.3,0.25,0,80,unavailable,0,0,18.7,"skin: 18.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197683,KRTAP26-1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"skin: 6.5000% (minimum 65%, Missing)",-0.585,0.3,0.25,0,80,unavailable,0,0,18.7,"skin: 18.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197683,KRTAP26-1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"skin: 6.5000% (minimum 65%, Missing)",-0.585,0.3,0.25,0,80,unavailable,0,0,18.7,"skin: 18.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197683,KRTAP26-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"skin: 6.5000% (minimum 65%, Baseline (adaptation disabled))",-0.585,0.3,0.25,0,80,unavailable,0,0,18.7,"skin: 18.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197683,KRTAP26-1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 95%, Missing); adrenal gland: 31.4286% (minimum 99%, Missing); amygdala: 75.8621% (minimum 99%, Missing); basal ganglia: 73.3333% (minimum 99%, Missing); bone marrow: 27.1605% (minimum 99%, Missing); cerebellum: 64.7059% (minimum 99%, Missing); cerebral cortex: 68.7500% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 70.9677% (minimum 97%, Missing); duodenum: 88.0000% (minimum 99%, Missing); esophagus: 64.7059% (minimum 97%, Missing); heart muscle: 61.1111% (minimum 99%, Missing); hippocampal formation: 75.8621% (minimum 99%, Missing); hypothalamus: 78.5714% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Missing); lung: 62.8571% (minimum 99%, Missing); lymph node: 73.3333% (minimum 97%, Missing); midbrain: 78.5714% (minimum 99%, Missing); pancreas: 68.7500% (minimum 99%, Missing); parathyroid gland: 62.8571% (minimum 97%, Missing); pituitary gland: 57.8947% (minimum 99%, Missing); rectum: 78.5714% (minimum 97%, Missing); retina: 46.8085% (minimum 99%, Missing); salivary gland: 62.8571% (minimum 97%, Missing); skeletal muscle: 59.4595% (minimum 99%, Missing); skin: 55.0000% (minimum 95%, Missing); small intestine: 75.8621% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 70.9677% (minimum 99%, Missing); spleen: 61.1111% (minimum 95%, Missing); stomach: 70.9677% (minimum 97%, Missing); thymus: 68.7500% (minimum 95%, Missing); thyroid gland: 61.1111% (minimum 95%, Missing); tongue: 64.7059% (minimum 97%, Missing); urinary bladder: 66.6667% (minimum 97%, Missing)",-0.4,-0.341429,-0.718395,0,80,unavailable,5.9,1.3,1.8,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197714,ZNF460,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); adrenal gland: 31.4286% (minimum 75%, Missing); basal ganglia: 73.3333% (minimum 75%, Missing); bone marrow: 27.1605% (minimum 75%, Missing); cerebellum: 64.7059% (minimum 75%, Missing); cerebral cortex: 68.7500% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); esophagus: 64.7059% (minimum 70%, Missing); heart muscle: 61.1111% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 62.8571% (minimum 75%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 62.8571% (minimum 70%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); retina: 46.8085% (minimum 75%, Missing); salivary gland: 62.8571% (minimum 70%, Missing); skeletal muscle: 59.4595% (minimum 75%, Missing); skin: 55.0000% (minimum 65%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); thyroid gland: 61.1111% (minimum 65%, Missing); tongue: 64.7059% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",-0.1,-0.0714286,-0.478395,0,80,unavailable,5.9,1.3,1.8,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197714,ZNF460,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); adrenal gland: 31.4286% (minimum 75%, Missing); basal ganglia: 73.3333% (minimum 75%, Missing); bone marrow: 27.1605% (minimum 75%, Missing); cerebellum: 64.7059% (minimum 75%, Missing); cerebral cortex: 68.7500% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); esophagus: 64.7059% (minimum 70%, Missing); heart muscle: 61.1111% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 62.8571% (minimum 75%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 62.8571% (minimum 70%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); retina: 46.8085% (minimum 75%, Missing); salivary gland: 62.8571% (minimum 70%, Missing); skeletal muscle: 59.4595% (minimum 75%, Missing); skin: 55.0000% (minimum 65%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); thyroid gland: 61.1111% (minimum 65%, Missing); tongue: 64.7059% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",-0.1,-0.0714286,-0.478395,0,80,unavailable,5.9,1.3,1.8,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197714,ZNF460,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); adrenal gland: 31.4286% (minimum 75%, Missing); basal ganglia: 73.3333% (minimum 75%, Missing); bone marrow: 27.1605% (minimum 75%, Missing); cerebellum: 64.7059% (minimum 75%, Missing); cerebral cortex: 68.7500% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); esophagus: 64.7059% (minimum 70%, Missing); heart muscle: 61.1111% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 62.8571% (minimum 75%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 62.8571% (minimum 70%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); retina: 46.8085% (minimum 75%, Missing); salivary gland: 62.8571% (minimum 70%, Missing); skeletal muscle: 59.4595% (minimum 75%, Missing); skin: 55.0000% (minimum 65%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); thyroid gland: 61.1111% (minimum 65%, Missing); tongue: 64.7059% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",-0.1,-0.0714286,-0.478395,0,80,unavailable,5.9,1.3,1.8,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197714,ZNF460,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 31.4286% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.3333% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 27.1605% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.7059% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 68.7500% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.7059% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 61.1111% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 75%, Baseline (adaptation disabled)); lung: 62.8571% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.7500% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 62.8571% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 57.8947% (minimum 75%, Baseline (adaptation disabled)); retina: 46.8085% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.8571% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 59.4595% (minimum 75%, Baseline (adaptation disabled)); skin: 55.0000% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.9677% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.1111% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 61.1111% (minimum 65%, Baseline (adaptation disabled)); tongue: 64.7059% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 66.6667% (minimum 70%, Baseline (adaptation disabled))",-0.1,-0.0714286,-0.478395,0,80,unavailable,5.9,1.3,1.8,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197714,ZNF460,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4071% (minimum 99%, Missing); amygdala: 91.4474% (minimum 99%, Missing); basal ganglia: 84.8855% (minimum 99%, Missing); cerebellum: 98.5816% (minimum 99%, Missing); cerebral cortex: 97.0332% (minimum 99%, Missing); choroid plexus: 36.4590% (minimum 99%, Missing); hippocampal formation: 85.6703% (minimum 99%, Missing); hypothalamus: 82.3704% (minimum 99%, Missing); kidney: 90.7015% (minimum 99%, Missing); lung: 87.5591% (minimum 99%, Missing); midbrain: 95.3688% (minimum 99%, Missing); pancreas: 96.3605% (minimum 99%, Missing); parathyroid gland: 93.9189% (minimum 97%, Missing); pituitary gland: 85.0153% (minimum 99%, Missing); retina: 84.2424% (minimum 99%, Missing); small intestine: 98.9324% (minimum 99%, Missing); spinal cord: 95.5326% (minimum 99%, Missing); thyroid gland: 91.4474% (minimum 95%, Missing)",-0.0355263,-0.0308108,-0.62541,0,80,unavailable,96.9,3.6,5.2,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197748,CFAP43,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 36.4590% (minimum 75%, Missing)",0.264474,0.239189,-0.38541,0,80,unavailable,96.9,3.6,5.2,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197748,CFAP43,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 36.4590% (minimum 75%, Missing)",0.264474,0.239189,-0.38541,0,80,unavailable,96.9,3.6,5.2,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 3); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197748,CFAP43,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 36.4590% (minimum 75%, Missing)",0.264474,0.239189,-0.38541,0,80,unavailable,96.9,3.6,5.2,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 3); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197748,CFAP43,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 36.4590% (minimum 75%, Baseline (adaptation disabled))",0.264474,0.239189,-0.38541,0,80,unavailable,96.9,3.6,5.2,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 3); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197748,CFAP43,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 91.5743% (minimum 99%, Missing); kidney: 97.4057% (minimum 99%, Missing); liver: 96.4953% (minimum 99%, Missing); pancreas: 97.1765% (minimum 99%, Missing); pituitary gland: 98.3333% (minimum 99%, Missing); retina: 96.4953% (minimum 99%, Missing); salivary gland: 96.9484% (minimum 97%, Missing); small intestine: 93.6508% (minimum 99%, Missing)",0.0194836,-0.000516432,-0.0742572,0,80,unavailable,3.8,1.3,1.3,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197768,STPG3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319484,0.269484,0.165743,0,80,unavailable,3.8,1.3,1.3,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197768,STPG3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319484,0.269484,0.165743,0,80,unavailable,3.8,1.3,1.3,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197768,STPG3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319484,0.269484,0.165743,0,80,unavailable,3.8,1.3,1.3,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197768,STPG3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319484,0.269484,0.165743,0,80,unavailable,3.8,1.3,1.3,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197768,STPG3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.5238% (minimum 90%, Approved); adrenal gland: 58.1395% (minimum 99%, Missing); amygdala: 65.7895% (minimum 99%, Missing); basal ganglia: 65.7895% (minimum 99%, Missing); bone marrow: 43.8596% (minimum 98%, Approved); cerebellum: 56.8182% (minimum 99%, Missing); cerebral cortex: 54.3478% (minimum 99%, Missing); choroid plexus: 59.5238% (minimum 99%, Missing); colon: 52.0833% (minimum 97%, Missing); duodenum: 62.5000% (minimum 99%, Missing); esophagus: 54.3478% (minimum 97%, Missing); heart muscle: 42.3729% (minimum 99%, Missing); hippocampal formation: 67.5676% (minimum 99%, Missing); hypothalamus: 69.4444% (minimum 99%, Missing); kidney: 50.0000% (minimum 99%, Missing); liver: 62.5000% (minimum 99%, Missing); lung: 56.8182% (minimum 99%, Missing); lymph node: 53.1915% (minimum 97%, Missing); midbrain: 60.9756% (minimum 99%, Missing); pancreas: 59.5238% (minimum 99%, Missing); parathyroid gland: 42.3729% (minimum 97%, Missing); pituitary gland: 53.1915% (minimum 99%, Missing); rectum: 47.1698% (minimum 97%, Missing); retina: 37.3134% (minimum 99%, Missing); salivary gland: 62.5000% (minimum 97%, Missing); skeletal muscle: 58.1395% (minimum 99%, Missing); skin: 41.6667% (minimum 95%, Missing); small intestine: 60.9756% (minimum 99%, Missing); smooth muscle: 53.1915% (minimum 98%, Approved); spinal cord: 60.9756% (minimum 99%, Missing); spleen: 48.0769% (minimum 95%, Missing); stomach: 59.5238% (minimum 97%, Missing); thymus: 46.2963% (minimum 95%, Missing); thyroid gland: 47.1698% (minimum 95%, Missing); tongue: 73.5294% (minimum 97%, Missing); urinary bladder: 55.5556% (minimum 97%, Missing)",-0.533333,-0.546271,-0.616866,0,2,partial,4.2,3.4,3.5,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 2); rectum: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197779,ZNF81,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.5238% (minimum 60%, Approved); adrenal gland: 58.1395% (minimum 75%, Missing); amygdala: 65.7895% (minimum 75%, Missing); basal ganglia: 65.7895% (minimum 75%, Missing); bone marrow: 43.8596% (minimum 70%, Approved); cerebellum: 56.8182% (minimum 75%, Missing); cerebral cortex: 54.3478% (minimum 75%, Missing); choroid plexus: 59.5238% (minimum 75%, Missing); colon: 52.0833% (minimum 70%, Missing); duodenum: 62.5000% (minimum 75%, Missing); esophagus: 54.3478% (minimum 70%, Missing); heart muscle: 42.3729% (minimum 75%, Missing); hippocampal formation: 67.5676% (minimum 75%, Missing); hypothalamus: 69.4444% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 62.5000% (minimum 75%, Missing); lung: 56.8182% (minimum 75%, Missing); lymph node: 53.1915% (minimum 70%, Missing); midbrain: 60.9756% (minimum 75%, Missing); pancreas: 59.5238% (minimum 75%, Missing); parathyroid gland: 42.3729% (minimum 70%, Missing); pituitary gland: 53.1915% (minimum 75%, Missing); rectum: 47.1698% (minimum 70%, Missing); retina: 37.3134% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 58.1395% (minimum 75%, Missing); skin: 41.6667% (minimum 65%, Missing); small intestine: 60.9756% (minimum 75%, Missing); smooth muscle: 53.1915% (minimum 70%, Approved); spinal cord: 60.9756% (minimum 75%, Missing); spleen: 48.0769% (minimum 65%, Missing); stomach: 59.5238% (minimum 70%, Missing); thymus: 46.2963% (minimum 65%, Missing); thyroid gland: 47.1698% (minimum 65%, Missing); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.233333,-0.276271,-0.376866,0,2,partial,4.2,3.4,3.5,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 2); rectum: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197779,ZNF81,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.5238% (minimum 60%, Approved); adrenal gland: 58.1395% (minimum 75%, Missing); amygdala: 65.7895% (minimum 75%, Missing); basal ganglia: 65.7895% (minimum 75%, Missing); bone marrow: 43.8596% (minimum 70%, Approved); cerebellum: 56.8182% (minimum 75%, Missing); cerebral cortex: 54.3478% (minimum 75%, Missing); choroid plexus: 59.5238% (minimum 75%, Missing); colon: 52.0833% (minimum 70%, Missing); duodenum: 62.5000% (minimum 75%, Missing); esophagus: 54.3478% (minimum 70%, Missing); heart muscle: 42.3729% (minimum 75%, Missing); hippocampal formation: 67.5676% (minimum 75%, Missing); hypothalamus: 69.4444% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 62.5000% (minimum 75%, Missing); lung: 56.8182% (minimum 75%, Missing); lymph node: 53.1915% (minimum 70%, Missing); midbrain: 60.9756% (minimum 75%, Missing); pancreas: 59.5238% (minimum 75%, Missing); parathyroid gland: 42.3729% (minimum 70%, Missing); pituitary gland: 53.1915% (minimum 75%, Missing); rectum: 47.1698% (minimum 70%, Missing); retina: 37.3134% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 58.1395% (minimum 75%, Missing); skin: 41.6667% (minimum 65%, Missing); small intestine: 60.9756% (minimum 75%, Missing); smooth muscle: 53.1915% (minimum 70%, Approved); spinal cord: 60.9756% (minimum 75%, Missing); spleen: 48.0769% (minimum 65%, Missing); stomach: 59.5238% (minimum 70%, Missing); thymus: 46.2963% (minimum 65%, Missing); thyroid gland: 47.1698% (minimum 65%, Missing); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.233333,-0.276271,-0.376866,0,2,partial,4.2,3.4,3.5,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 2); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197779,ZNF81,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.5238% (minimum 60%, Approved); adrenal gland: 58.1395% (minimum 75%, Missing); amygdala: 65.7895% (minimum 75%, Missing); basal ganglia: 65.7895% (minimum 75%, Missing); bone marrow: 43.8596% (minimum 70%, Approved); cerebellum: 56.8182% (minimum 75%, Missing); cerebral cortex: 54.3478% (minimum 75%, Missing); choroid plexus: 59.5238% (minimum 75%, Missing); colon: 52.0833% (minimum 70%, Missing); duodenum: 62.5000% (minimum 75%, Missing); esophagus: 54.3478% (minimum 70%, Missing); heart muscle: 42.3729% (minimum 75%, Missing); hippocampal formation: 67.5676% (minimum 75%, Missing); hypothalamus: 69.4444% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 62.5000% (minimum 75%, Missing); lung: 56.8182% (minimum 75%, Missing); lymph node: 53.1915% (minimum 70%, Missing); midbrain: 60.9756% (minimum 75%, Missing); pancreas: 59.5238% (minimum 75%, Missing); parathyroid gland: 42.3729% (minimum 70%, Missing); pituitary gland: 53.1915% (minimum 75%, Missing); rectum: 47.1698% (minimum 70%, Missing); retina: 37.3134% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 58.1395% (minimum 75%, Missing); skin: 41.6667% (minimum 65%, Missing); small intestine: 60.9756% (minimum 75%, Missing); smooth muscle: 53.1915% (minimum 70%, Approved); spinal cord: 60.9756% (minimum 75%, Missing); spleen: 48.0769% (minimum 65%, Missing); stomach: 59.5238% (minimum 70%, Missing); thymus: 46.2963% (minimum 65%, Missing); thyroid gland: 47.1698% (minimum 65%, Missing); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.233333,-0.276271,-0.376866,0,2,partial,4.2,3.4,3.5,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 2); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197779,ZNF81,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.5238% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 58.1395% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.7895% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.7895% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 43.8596% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 56.8182% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 54.3478% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 59.5238% (minimum 75%, Baseline (adaptation disabled)); colon: 52.0833% (minimum 70%, Baseline (adaptation disabled)); duodenum: 62.5000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 54.3478% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 42.3729% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 67.5676% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.4444% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 62.5000% (minimum 75%, Baseline (adaptation disabled)); lung: 56.8182% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.1915% (minimum 70%, Baseline (adaptation disabled)); midbrain: 60.9756% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.5238% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 42.3729% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 53.1915% (minimum 75%, Baseline (adaptation disabled)); rectum: 47.1698% (minimum 70%, Baseline (adaptation disabled)); retina: 37.3134% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 58.1395% (minimum 75%, Baseline (adaptation disabled)); skin: 41.6667% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.9756% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 53.1915% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 60.9756% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.0769% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.5238% (minimum 70%, Baseline (adaptation disabled)); thymus: 46.2963% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 47.1698% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 55.5556% (minimum 70%, Baseline (adaptation disabled))",-0.233333,-0.276271,-0.376866,0,2,partial,4.2,3.4,3.5,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197779,ZNF81,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.7987% (minimum 90%, Approved); adrenal gland: 67.0968% (minimum 99%, Missing); amygdala: 59.4286% (minimum 99%, Missing); basal ganglia: 47.4886% (minimum 99%, Missing); bone marrow: 83.2000% (minimum 99%, Missing); cerebellum: 78.7879% (minimum 99%, Missing); cerebral cortex: 57.9387% (minimum 99%, Missing); choroid plexus: 41.1067% (minimum 99%, Missing); colon: 47.2727% (minimum 97%, Missing); duodenum: 53.6082% (minimum 99%, Missing); esophagus: 73.7589% (minimum 97%, Missing); heart muscle: 54.1667% (minimum 99%, Missing); hippocampal formation: 63.6086% (minimum 99%, Missing); hypothalamus: 65.8228% (minimum 99%, Missing); kidney: 67.5325% (minimum 99%, Missing); liver: 70.5085% (minimum 99%, Missing); lung: 56.9863% (minimum 99%, Missing); lymph node: 62.6506% (minimum 97%, Missing); midbrain: 64.0000% (minimum 99%, Missing); pancreas: 79.0875% (minimum 99%, Missing); parathyroid gland: 73.7589% (minimum 97%, Missing); pituitary gland: 70.2703% (minimum 99%, Missing); rectum: 47.5973% (minimum 97%, Missing); retina: 70.2703% (minimum 99%, Missing); salivary gland: 72.7273% (minimum 97%, Missing); skeletal muscle: 49.5238% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 62.0896% (minimum 99%, Missing); smooth muscle: 60.2899% (minimum 99%, Missing); spinal cord: 63.0303% (minimum 99%, Missing); spleen: 67.0968% (minimum 95%, Missing); stomach: 58.9235% (minimum 97%, Missing); thymus: 60.2899% (minimum 95%, Missing); thyroid gland: 67.7524% (minimum 95%, Missing); tongue: 56.9863% (minimum 97%, Missing); urinary bladder: 61.3569% (minimum 97%, Missing)",-0.347101,-0.497273,-0.578933,0,6,partial,29.8,23.2,13.7,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 2); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 2); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 2); lung: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 2); amygdala: 14.2 nTPM (vital, limit 1); smooth muscle: 13.7 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.1 nTPM (protected, limit 2); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 2); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); adrenal gland: 10.2 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pituitary gland: 8.8 nTPM (vital, limit 1); retina: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197798,FAM118B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.0968% (minimum 75%, Missing); amygdala: 59.4286% (minimum 75%, Missing); basal ganglia: 47.4886% (minimum 75%, Missing); cerebral cortex: 57.9387% (minimum 75%, Missing); choroid plexus: 41.1067% (minimum 75%, Missing); colon: 47.2727% (minimum 70%, Missing); duodenum: 53.6082% (minimum 75%, Missing); heart muscle: 54.1667% (minimum 75%, Missing); hippocampal formation: 63.6086% (minimum 75%, Missing); hypothalamus: 65.8228% (minimum 75%, Missing); kidney: 67.5325% (minimum 75%, Missing); liver: 70.5085% (minimum 75%, Missing); lung: 56.9863% (minimum 75%, Missing); lymph node: 62.6506% (minimum 70%, Missing); midbrain: 64.0000% (minimum 75%, Missing); pituitary gland: 70.2703% (minimum 75%, Missing); rectum: 47.5973% (minimum 70%, Missing); retina: 70.2703% (minimum 75%, Missing); skeletal muscle: 49.5238% (minimum 75%, Missing); small intestine: 62.0896% (minimum 75%, Missing); smooth muscle: 60.2899% (minimum 75%, Missing); spinal cord: 63.0303% (minimum 75%, Missing); stomach: 58.9235% (minimum 70%, Missing); thymus: 60.2899% (minimum 65%, Missing); tongue: 56.9863% (minimum 70%, Missing); urinary bladder: 61.3569% (minimum 70%, Missing)",-0.0471014,-0.227273,-0.338933,0,6,partial,29.8,23.2,13.7,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 2); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 2); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 2); lung: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 2); amygdala: 14.2 nTPM (vital, limit 1); smooth muscle: 13.7 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.1 nTPM (protected, limit 2); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 2); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); adrenal gland: 10.2 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pituitary gland: 8.8 nTPM (vital, limit 1); retina: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197798,FAM118B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.0968% (minimum 75%, Missing); amygdala: 59.4286% (minimum 75%, Missing); basal ganglia: 47.4886% (minimum 75%, Missing); cerebral cortex: 57.9387% (minimum 75%, Missing); choroid plexus: 41.1067% (minimum 75%, Missing); colon: 47.2727% (minimum 70%, Missing); duodenum: 53.6082% (minimum 75%, Missing); heart muscle: 54.1667% (minimum 75%, Missing); hippocampal formation: 63.6086% (minimum 75%, Missing); hypothalamus: 65.8228% (minimum 75%, Missing); kidney: 67.5325% (minimum 75%, Missing); liver: 70.5085% (minimum 75%, Missing); lung: 56.9863% (minimum 75%, Missing); lymph node: 62.6506% (minimum 70%, Missing); midbrain: 64.0000% (minimum 75%, Missing); pituitary gland: 70.2703% (minimum 75%, Missing); rectum: 47.5973% (minimum 70%, Missing); retina: 70.2703% (minimum 75%, Missing); skeletal muscle: 49.5238% (minimum 75%, Missing); small intestine: 62.0896% (minimum 75%, Missing); smooth muscle: 60.2899% (minimum 75%, Missing); spinal cord: 63.0303% (minimum 75%, Missing); stomach: 58.9235% (minimum 70%, Missing); thymus: 60.2899% (minimum 65%, Missing); tongue: 56.9863% (minimum 70%, Missing); urinary bladder: 61.3569% (minimum 70%, Missing)",-0.0471014,-0.227273,-0.338933,0,6,partial,29.8,23.2,13.7,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 3); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 3); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 3); lung: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 3); amygdala: 14.2 nTPM (vital, limit 1); smooth muscle: 13.7 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.1 nTPM (protected, limit 3); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 3); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); adrenal gland: 10.2 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pituitary gland: 8.8 nTPM (vital, limit 1); retina: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 3); parathyroid gland: 7.4 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197798,FAM118B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.0968% (minimum 75%, Missing); amygdala: 59.4286% (minimum 75%, Missing); basal ganglia: 47.4886% (minimum 75%, Missing); cerebral cortex: 57.9387% (minimum 75%, Missing); choroid plexus: 41.1067% (minimum 75%, Missing); colon: 47.2727% (minimum 70%, Missing); duodenum: 53.6082% (minimum 75%, Missing); heart muscle: 54.1667% (minimum 75%, Missing); hippocampal formation: 63.6086% (minimum 75%, Missing); hypothalamus: 65.8228% (minimum 75%, Missing); kidney: 67.5325% (minimum 75%, Missing); liver: 70.5085% (minimum 75%, Missing); lung: 56.9863% (minimum 75%, Missing); lymph node: 62.6506% (minimum 70%, Missing); midbrain: 64.0000% (minimum 75%, Missing); pituitary gland: 70.2703% (minimum 75%, Missing); rectum: 47.5973% (minimum 70%, Missing); retina: 70.2703% (minimum 75%, Missing); skeletal muscle: 49.5238% (minimum 75%, Missing); small intestine: 62.0896% (minimum 75%, Missing); smooth muscle: 60.2899% (minimum 75%, Missing); spinal cord: 63.0303% (minimum 75%, Missing); stomach: 58.9235% (minimum 70%, Missing); thymus: 60.2899% (minimum 65%, Missing); tongue: 56.9863% (minimum 70%, Missing); urinary bladder: 61.3569% (minimum 70%, Missing)",-0.0471014,-0.227273,-0.338933,0,6,partial,29.8,23.2,13.7,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 3); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 3); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 3); lung: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 3); amygdala: 14.2 nTPM (vital, limit 1); smooth muscle: 13.7 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.1 nTPM (protected, limit 3); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 3); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); adrenal gland: 10.2 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pituitary gland: 8.8 nTPM (vital, limit 1); retina: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 3); parathyroid gland: 7.4 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197798,FAM118B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.0968% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.4286% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 47.4886% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.9387% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 41.1067% (minimum 75%, Baseline (adaptation disabled)); colon: 47.2727% (minimum 70%, Baseline (adaptation disabled)); duodenum: 53.6082% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 54.1667% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.6086% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.8228% (minimum 75%, Baseline (adaptation disabled)); kidney: 67.5325% (minimum 75%, Baseline (adaptation disabled)); liver: 70.5085% (minimum 75%, Baseline (adaptation disabled)); lung: 56.9863% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.6506% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 70.2703% (minimum 75%, Baseline (adaptation disabled)); rectum: 47.5973% (minimum 70%, Baseline (adaptation disabled)); retina: 70.2703% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 49.5238% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.0896% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.2899% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.0303% (minimum 75%, Baseline (adaptation disabled)); stomach: 58.9235% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.2899% (minimum 65%, Baseline (adaptation disabled)); tongue: 56.9863% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.3569% (minimum 70%, Baseline (adaptation disabled))",-0.0471014,-0.227273,-0.338933,0,6,partial,29.8,23.2,13.7,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 3); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 3); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 3); lung: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 3); amygdala: 14.2 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); smooth muscle: 13.7 nTPM (vital, limit 1); urinary bladder: 13.1 nTPM (protected, limit 3); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 3); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); adipose tissue: 9 nTPM (manageable, limit 5); pituitary gland: 8.8 nTPM (vital, limit 1); retina: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 3); parathyroid gland: 7.4 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197798,FAM118B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.9929% (minimum 99%, Missing); basal ganglia: 91.7241% (minimum 99%, Missing); cerebellum: 96.3768% (minimum 98%, Approved); choroid plexus: 83.9117% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 90.1695% (minimum 99%, Missing); lung: 95.0000% (minimum 98%, Approved); midbrain: 98.5185% (minimum 99%, Missing); retina: 97.4359% (minimum 99%, Missing); spinal cord: 98.1550% (minimum 99%, Missing)",0.0462547,0.03,-0.150883,0,6,partial,5.1,0.1,0.5,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197826,CFAP299,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346255,0.3,0.0891167,0,6,partial,5.1,0.1,0.5,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197826,CFAP299,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346255,0.3,0.0891167,0,6,partial,5.1,0.1,0.5,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197826,CFAP299,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346255,0.3,0.0891167,0,6,partial,5.1,0.1,0.5,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197826,CFAP299,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.33155,0.296255,0.0891167,0,6,partial,5.1,0.1,0.5,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197826,CFAP299,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 99%, Missing); retina: 66.6667% (minimum 99%, Missing)",0.05,0.03,-0.323333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197849,OR8G1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.0833333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197849,OR8G1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.0833333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197849,OR8G1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.0833333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197849,OR8G1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.0833333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000197849,OR8G1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.8865% (minimum 95%, Missing); adrenal gland: 69.4805% (minimum 99%, Missing); amygdala: 74.3056% (minimum 99%, Missing); basal ganglia: 74.8252% (minimum 99%, Missing); bone marrow: 83.5938% (minimum 99%, Missing); cerebellum: 76.9784% (minimum 99%, Missing); cerebral cortex: 70.3947% (minimum 99%, Missing); choroid plexus: 68.1529% (minimum 99%, Missing); colon: 78.1022% (minimum 97%, Missing); duodenum: 73.7931% (minimum 99%, Missing); esophagus: 71.8121% (minimum 97%, Uncertain); heart muscle: 66.8750% (minimum 99%, Uncertain); hippocampal formation: 76.4286% (minimum 99%, Missing); hypothalamus: 76.9784% (minimum 99%, Missing); kidney: 65.2439% (minimum 99%, Missing); liver: 55.7292% (minimum 99%, Missing); lung: 74.8252% (minimum 99%, Missing); lymph node: 66.8750% (minimum 97%, Missing); midbrain: 75.3521% (minimum 99%, Missing); pancreas: 71.3333% (minimum 99%, Missing); parathyroid gland: 65.6442% (minimum 97%, Uncertain); pituitary gland: 78.6765% (minimum 99%, Missing); rectum: 81.0606% (minimum 97%, Missing); retina: 57.8378% (minimum 99%, Missing); salivary gland: 78.6765% (minimum 97%, Missing); skeletal muscle: 69.0323% (minimum 99%, Missing); skin: 53.7688% (minimum 95%, Missing); small intestine: 74.8252% (minimum 99%, Missing); smooth muscle: 76.9784% (minimum 99%, Missing); spinal cord: 78.1022% (minimum 99%, Missing); spleen: 69.9346% (minimum 95%, Uncertain); stomach: 69.4805% (minimum 97%, Missing); thymus: 71.8121% (minimum 95%, Missing); thyroid gland: 57.8378% (minimum 95%, Missing); tongue: 69.0323% (minimum 97%, Missing); urinary bladder: 75.3521% (minimum 97%, Missing)",-0.412312,-0.313558,-0.432708,0,2,partial,8.5,5.6,9.2,"skin: 9.2 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 2); lymph node: 5.3 nTPM (protected, limit 2); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); tongue: 4.8 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197863,ZNF790,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.4805% (minimum 75%, Missing); amygdala: 74.3056% (minimum 75%, Missing); basal ganglia: 74.8252% (minimum 75%, Missing); cerebral cortex: 70.3947% (minimum 75%, Missing); choroid plexus: 68.1529% (minimum 75%, Missing); duodenum: 73.7931% (minimum 75%, Missing); heart muscle: 66.8750% (minimum 75%, Uncertain); kidney: 65.2439% (minimum 75%, Missing); liver: 55.7292% (minimum 75%, Missing); lung: 74.8252% (minimum 75%, Missing); lymph node: 66.8750% (minimum 70%, Missing); pancreas: 71.3333% (minimum 75%, Missing); parathyroid gland: 65.6442% (minimum 70%, Uncertain); retina: 57.8378% (minimum 75%, Missing); skeletal muscle: 69.0323% (minimum 75%, Missing); skin: 53.7688% (minimum 65%, Missing); small intestine: 74.8252% (minimum 75%, Missing); stomach: 69.4805% (minimum 70%, Missing); thyroid gland: 57.8378% (minimum 65%, Missing); tongue: 69.0323% (minimum 70%, Missing)",-0.112312,-0.0435583,-0.192708,0,2,partial,8.5,5.6,9.2,"skin: 9.2 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 2); lymph node: 5.3 nTPM (protected, limit 2); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); tongue: 4.8 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197863,ZNF790,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.4805% (minimum 75%, Missing); amygdala: 74.3056% (minimum 75%, Missing); basal ganglia: 74.8252% (minimum 75%, Missing); cerebral cortex: 70.3947% (minimum 75%, Missing); choroid plexus: 68.1529% (minimum 75%, Missing); duodenum: 73.7931% (minimum 75%, Missing); heart muscle: 66.8750% (minimum 75%, Uncertain); kidney: 65.2439% (minimum 75%, Missing); liver: 55.7292% (minimum 75%, Missing); lung: 74.8252% (minimum 75%, Missing); lymph node: 66.8750% (minimum 70%, Missing); pancreas: 71.3333% (minimum 75%, Missing); parathyroid gland: 65.6442% (minimum 70%, Uncertain); retina: 57.8378% (minimum 75%, Missing); skeletal muscle: 69.0323% (minimum 75%, Missing); skin: 53.7688% (minimum 65%, Missing); small intestine: 74.8252% (minimum 75%, Missing); stomach: 69.4805% (minimum 70%, Missing); thyroid gland: 57.8378% (minimum 65%, Missing); tongue: 69.0323% (minimum 70%, Missing)",-0.112312,-0.0435583,-0.192708,0,2,partial,8.5,5.6,9.2,"skin: 9.2 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 3); lymph node: 5.3 nTPM (protected, limit 3); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); tongue: 4.8 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197863,ZNF790,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.4805% (minimum 75%, Missing); amygdala: 74.3056% (minimum 75%, Missing); basal ganglia: 74.8252% (minimum 75%, Missing); cerebral cortex: 70.3947% (minimum 75%, Missing); choroid plexus: 68.1529% (minimum 75%, Missing); duodenum: 73.7931% (minimum 75%, Missing); heart muscle: 66.8750% (minimum 75%, Uncertain); kidney: 65.2439% (minimum 75%, Missing); liver: 55.7292% (minimum 75%, Missing); lung: 74.8252% (minimum 75%, Missing); lymph node: 66.8750% (minimum 70%, Missing); pancreas: 71.3333% (minimum 75%, Missing); parathyroid gland: 65.6442% (minimum 70%, Uncertain); retina: 57.8378% (minimum 75%, Missing); skeletal muscle: 69.0323% (minimum 75%, Missing); skin: 53.7688% (minimum 65%, Missing); small intestine: 74.8252% (minimum 75%, Missing); stomach: 69.4805% (minimum 70%, Missing); thyroid gland: 57.8378% (minimum 65%, Missing); tongue: 69.0323% (minimum 70%, Missing)",-0.112312,-0.0435583,-0.192708,0,2,partial,8.5,5.6,9.2,"skin: 9.2 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 3); lymph node: 5.3 nTPM (protected, limit 3); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); tongue: 4.8 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197863,ZNF790,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.4805% (minimum 75%, Baseline (adaptation disabled)); amygdala: 74.3056% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.8252% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.3947% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.1529% (minimum 75%, Baseline (adaptation disabled)); duodenum: 73.7931% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 66.8750% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.2439% (minimum 75%, Baseline (adaptation disabled)); liver: 55.7292% (minimum 75%, Baseline (adaptation disabled)); lung: 74.8252% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.8750% (minimum 70%, Baseline (adaptation disabled)); pancreas: 71.3333% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 65.6442% (minimum 70%, Baseline (adaptation disabled)); retina: 57.8378% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 69.0323% (minimum 75%, Baseline (adaptation disabled)); skin: 53.7688% (minimum 65%, Baseline (adaptation disabled)); small intestine: 74.8252% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.4805% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 57.8378% (minimum 65%, Baseline (adaptation disabled)); tongue: 69.0323% (minimum 70%, Baseline (adaptation disabled))",-0.112312,-0.0435583,-0.192708,0,2,partial,8.5,5.6,9.2,"skin: 9.2 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 3); lymph node: 5.3 nTPM (protected, limit 3); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); tongue: 4.8 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197863,ZNF790,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.0588% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 90.0000% (minimum 99%, Missing); cerebellum: 96.1165% (minimum 99%, Missing); cerebral cortex: 93.3962% (minimum 99%, Missing); choroid plexus: 94.2857% (minimum 99%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 90.8257% (minimum 99%, Missing); kidney: 97.0588% (minimum 99%, Missing); liver: 98.0198% (minimum 99%, Missing); lung: 96.1165% (minimum 99%, Missing); midbrain: 90.8257% (minimum 99%, Missing); pancreas: 98.0198% (minimum 99%, Missing); pituitary gland: 92.5234% (minimum 99%, Missing); retina: 96.1165% (minimum 99%, Missing); spinal cord: 93.3962% (minimum 99%, Missing)",0.030198,0.010198,-0.09,0,80,unavailable,1.1,0.2,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197889,MEIG1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.330198,0.280198,0.15,0,80,unavailable,1.1,0.2,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197889,MEIG1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.330198,0.280198,0.15,0,80,unavailable,1.1,0.2,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197889,MEIG1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.330198,0.280198,0.15,0,80,unavailable,1.1,0.2,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197889,MEIG1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.330198,0.280198,0.15,0,80,unavailable,1.1,0.2,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197889,MEIG1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.1740% (minimum 90%, Approved); adrenal gland: 87.7016% (minimum 99%, Missing); amygdala: 91.7722% (minimum 99%, Missing); basal ganglia: 91.5789% (minimum 99%, Missing); bone marrow: 88.9571% (minimum 99%, Missing); cerebellum: 90.8142% (minimum 99%, Missing); cerebral cortex: 84.9609% (minimum 99%, Missing); choroid plexus: 92.1610% (minimum 99%, Missing); colon: 86.8263% (minimum 97%, Missing); duodenum: 92.7505% (minimum 99%, Missing); esophagus: 89.1393% (minimum 97%, Missing); heart muscle: 79.8165% (minimum 99%, Missing); hippocampal formation: 91.9662% (minimum 99%, Missing); hypothalamus: 93.3476% (minimum 99%, Missing); kidney: 87.5252% (minimum 99%, Missing); liver: 94.1558% (minimum 99%, Missing); lung: 87.7016% (minimum 99%, Missing); lymph node: 87.5252% (minimum 95%, Approved); midbrain: 93.3476% (minimum 99%, Missing); pancreas: 89.3224% (minimum 99%, Missing); parathyroid gland: 82.3864% (minimum 97%, Missing); pituitary gland: 90.2490% (minimum 99%, Missing); rectum: 91.7722% (minimum 97%, Missing); retina: 79.3796% (minimum 99%, Missing); salivary gland: 85.1272% (minimum 97%, Missing); skeletal muscle: 89.5062% (minimum 99%, Missing); skin: 83.3333% (minimum 95%, Missing); small intestine: 92.9487% (minimum 99%, Missing); smooth muscle: 82.8571% (minimum 99%, Missing); spinal cord: 90.4366% (minimum 99%, Missing); spleen: 83.3333% (minimum 90%, Approved); stomach: 89.3224% (minimum 97%, Missing); thymus: 82.8571% (minimum 95%, Missing); thyroid gland: 79.0909% (minimum 95%, Missing); tongue: 86.3095% (minimum 97%, Missing); urinary bladder: 85.2941% (minimum 97%, Missing)",-0.159091,-0.146136,-0.196204,0,6,partial,11.3,9.3,11.5,"thyroid gland: 11.5 nTPM (manageable, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 2); thymus: 9 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); skin: 8.7 nTPM (manageable, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); salivary gland: 7.6 nTPM (protected, limit 2); urinary bladder: 7.5 nTPM (protected, limit 2); tongue: 6.9 nTPM (protected, limit 2); colon: 6.6 nTPM (protected, limit 2); kidney: 6.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 4); lung: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 2); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197928,ZNF677,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.140909,0.123864,0.0437956,0,6,partial,11.3,9.3,11.5,"thyroid gland: 11.5 nTPM (manageable, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 2); thymus: 9 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); skin: 8.7 nTPM (manageable, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); salivary gland: 7.6 nTPM (protected, limit 2); urinary bladder: 7.5 nTPM (protected, limit 2); tongue: 6.9 nTPM (protected, limit 2); colon: 6.6 nTPM (protected, limit 2); kidney: 6.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 4); lung: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 2); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197928,ZNF677,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.140909,0.123864,0.0437956,0,6,partial,11.3,9.3,11.5,"thyroid gland: 11.5 nTPM (manageable, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 3); thymus: 9 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); skin: 8.7 nTPM (manageable, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); salivary gland: 7.6 nTPM (protected, limit 3); urinary bladder: 7.5 nTPM (protected, limit 3); tongue: 6.9 nTPM (protected, limit 3); colon: 6.6 nTPM (protected, limit 3); kidney: 6.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 4); lung: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.2 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 3); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197928,ZNF677,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.140909,0.123864,0.0437956,0,6,partial,11.3,9.3,11.5,"thyroid gland: 11.5 nTPM (manageable, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 3); thymus: 9 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); skin: 8.7 nTPM (manageable, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); salivary gland: 7.6 nTPM (protected, limit 3); urinary bladder: 7.5 nTPM (protected, limit 3); tongue: 6.9 nTPM (protected, limit 3); colon: 6.6 nTPM (protected, limit 3); kidney: 6.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 4); lung: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.2 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 3); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197928,ZNF677,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.140909,0.123864,0.0437956,0,6,partial,11.3,9.3,11.5,"thyroid gland: 11.5 nTPM (manageable, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 3); thymus: 9 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); skin: 8.7 nTPM (manageable, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); salivary gland: 7.6 nTPM (protected, limit 3); urinary bladder: 7.5 nTPM (protected, limit 3); tongue: 6.9 nTPM (protected, limit 3); colon: 6.6 nTPM (protected, limit 3); kidney: 6.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); stomach: 5.2 nTPM (protected, limit 3); pancreas: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197928,ZNF677,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.7586% (minimum 90%, Approved); adrenal gland: 82.7586% (minimum 98%, Approved); amygdala: 85.7143% (minimum 99%, Missing); basal ganglia: 85.7143% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 99%, Missing); cerebral cortex: 92.3077% (minimum 99%, Missing); colon: 77.4194% (minimum 95%, Approved); esophagus: 80.0000% (minimum 95%, Approved); heart muscle: 88.8889% (minimum 98%, Approved); hippocampal formation: 85.7143% (minimum 99%, Missing); hypothalamus: 85.7143% (minimum 99%, Missing); kidney: 70.5882% (minimum 98%, Approved); liver: 77.4194% (minimum 98%, Approved); lung: 88.8889% (minimum 98%, Approved); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 82.7586% (minimum 98%, Approved); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 92.3077% (minimum 95%, Approved); salivary gland: 80.0000% (minimum 95%, Approved); skeletal muscle: 96.0000% (minimum 98%, Approved); skin: 82.7586% (minimum 90%, Approved); small intestine: 82.7586% (minimum 98%, Approved); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 80.0000% (minimum 90%, Approved); stomach: 82.7586% (minimum 95%, Approved); thyroid gland: 68.5714% (minimum 90%, Approved); urinary bladder: 77.4194% (minimum 95%, Approved)",-0.214286,-0.175806,-0.274118,0,2,partial,1,0.7,1.1,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197935,ZNF311,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0857143,0.124194,0.00588235,0,2,partial,1,0.7,1.1,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197935,ZNF311,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0857143,0.124194,0.00588235,0,2,partial,1,0.7,1.1,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197935,ZNF311,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0857143,0.124194,0.00588235,0,2,partial,1,0.7,1.1,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197935,ZNF311,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"kidney: 70.5882% (minimum 75%, Baseline (adaptation disabled))",0.0357143,0.0741935,-0.0441176,0,2,partial,1,0.7,1.1,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197935,ZNF311,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7077% (minimum 99%, Missing); amygdala: 75.7778% (minimum 99%, Missing); basal ganglia: 73.0193% (minimum 99%, Missing); cerebellum: 85.4637% (minimum 99%, Missing); cerebral cortex: 72.2458% (minimum 99%, Missing); choroid plexus: 97.4286% (minimum 99%, Missing); heart muscle: 91.6667% (minimum 99%, Missing); hippocampal formation: 82.7670% (minimum 99%, Missing); hypothalamus: 86.5482% (minimum 99%, Missing); liver: 40.1176% (minimum 99%, Missing); midbrain: 81.3842% (minimum 99%, Missing); pancreas: 93.1694% (minimum 99%, Missing); parathyroid gland: 78.3908% (minimum 97%, Missing); pituitary gland: 92.1622% (minimum 99%, Missing); retina: 55.8101% (minimum 99%, Missing); skeletal muscle: 97.1510% (minimum 99%, Missing); smooth muscle: 97.9885% (minimum 99%, Missing); spinal cord: 62.5688% (minimum 99%, Missing); urinary bladder: 94.4598% (minimum 97%, Missing)",0.00251397,-0.186092,-0.588824,0,80,unavailable,50.9,9.4,1.7,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 2); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197977,ELOVL2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 73.0193% (minimum 75%, Missing); cerebral cortex: 72.2458% (minimum 75%, Missing); liver: 40.1176% (minimum 75%, Missing); retina: 55.8101% (minimum 75%, Missing); spinal cord: 62.5688% (minimum 75%, Missing)",0.302514,0.083908,-0.348824,0,80,unavailable,50.9,9.4,1.7,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 2); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197977,ELOVL2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 73.0193% (minimum 75%, Missing); cerebral cortex: 72.2458% (minimum 75%, Missing); liver: 40.1176% (minimum 75%, Missing); retina: 55.8101% (minimum 75%, Missing); spinal cord: 62.5688% (minimum 75%, Missing)",0.302514,0.083908,-0.348824,0,80,unavailable,50.9,9.4,1.7,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 3); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197977,ELOVL2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 73.0193% (minimum 75%, Missing); cerebral cortex: 72.2458% (minimum 75%, Missing); liver: 40.1176% (minimum 75%, Missing); retina: 55.8101% (minimum 75%, Missing); spinal cord: 62.5688% (minimum 75%, Missing)",0.302514,0.083908,-0.348824,0,80,unavailable,50.9,9.4,1.7,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 3); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197977,ELOVL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 73.0193% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.2458% (minimum 75%, Baseline (adaptation disabled)); liver: 40.1176% (minimum 75%, Baseline (adaptation disabled)); retina: 55.8101% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.5688% (minimum 75%, Baseline (adaptation disabled))",0.302514,0.083908,-0.348824,0,80,unavailable,50.9,9.4,1.7,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 3); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000197977,ELOVL2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198021,SPANXA1,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198021,SPANXA1,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198021,SPANXA1,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198021,SPANXA1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198021,SPANXA1,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 75.0000% (minimum 99%, Missing)",0.05,0.03,-0.24,0,80,unavailable,2,0,0,"retina: 2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198028,ZNF560,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0,0,80,unavailable,2,0,0,"retina: 2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198028,ZNF560,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0,0,80,unavailable,2,0,0,"retina: 2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198028,ZNF560,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0,0,80,unavailable,2,0,0,"retina: 2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198028,ZNF560,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0,0,80,unavailable,2,0,0,"retina: 2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198028,ZNF560,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.049746,0.0287313,0.00949213,0,80,unavailable,0.2,0.5,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198033,TUBA3C,admission_only,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.349746,0.298731,0.249492,0,80,unavailable,0.2,0.5,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198033,TUBA3C,selectivity_revised,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.349746,0.298731,0.249492,0,80,unavailable,0.2,0.5,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198033,TUBA3C,grid_revised,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.349746,0.298731,0.249492,0,80,unavailable,0.2,0.5,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198033,TUBA3C,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,family_exclusion,True,True,True,,0.349746,0.298731,0.249492,0,80,unavailable,0.2,0.5,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198033,TUBA3C,current_fixed,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198062,POTEH,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198062,POTEH,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198062,POTEH,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198062,POTEH,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198062,POTEH,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.7756% (minimum 99%, Missing); amygdala: 97.1264% (minimum 99%, Missing); basal ganglia: 94.4134% (minimum 99%, Missing); bone marrow: 88.4817% (minimum 98%, Approved); choroid plexus: 61.9048% (minimum 99%, Missing); colon: 86.6667% (minimum 97%, Missing); duodenum: 85.3535% (minimum 99%, Missing); esophagus: 92.8571% (minimum 95%, Approved); heart muscle: 90.3743% (minimum 98%, Approved); hippocampal formation: 95.4802% (minimum 99%, Missing); hypothalamus: 93.8889% (minimum 99%, Missing); kidney: 74.7788% (minimum 99%, Missing); liver: 90.3743% (minimum 98%, Approved); lung: 91.3514% (minimum 99%, Missing); lymph node: 93.3702% (minimum 95%, Approved); midbrain: 96.5714% (minimum 99%, Missing); pancreas: 80.0948% (minimum 98%, Approved); parathyroid gland: 80.8612% (minimum 97%, Missing); pituitary gland: 87.1134% (minimum 99%, Missing); rectum: 84.5000% (minimum 97%, Missing); retina: 94.4134% (minimum 99%, Missing); salivary gland: 89.4180% (minimum 95%, Approved); small intestine: 85.3535% (minimum 99%, Missing); spinal cord: 98.2558% (minimum 99%, Missing); stomach: 90.8602% (minimum 97%, Missing); thymus: 89.4180% (minimum 95%, Missing); thyroid gland: 63.5338% (minimum 95%, Missing); urinary bladder: 94.9438% (minimum 97%, Missing)",-0.314662,-0.161388,-0.432244,0,2,partial,13.4,4,9.7,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 2); parathyroid gland: 4 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198088,NUP62CL,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.7756% (minimum 75%, Missing); choroid plexus: 61.9048% (minimum 75%, Missing); kidney: 74.7788% (minimum 75%, Missing); thyroid gland: 63.5338% (minimum 65%, Missing)",-0.0146617,0.108612,-0.192244,0,2,partial,13.4,4,9.7,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 2); parathyroid gland: 4 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198088,NUP62CL,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.7756% (minimum 75%, Missing); choroid plexus: 61.9048% (minimum 75%, Missing); kidney: 74.7788% (minimum 75%, Missing); thyroid gland: 63.5338% (minimum 65%, Missing)",-0.0146617,0.108612,-0.192244,0,2,partial,13.4,4,9.7,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 2); parathyroid gland: 4 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198088,NUP62CL,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.7756% (minimum 75%, Missing); choroid plexus: 61.9048% (minimum 75%, Missing); kidney: 74.7788% (minimum 75%, Missing); thyroid gland: 63.5338% (minimum 65%, Missing)",-0.0146617,0.108612,-0.192244,0,2,partial,13.4,4,9.7,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 2); parathyroid gland: 4 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198088,NUP62CL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.7756% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 61.9048% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.7788% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 63.5338% (minimum 65%, Baseline (adaptation disabled))",-0.0146617,0.108612,-0.192244,0,2,partial,13.4,4,9.7,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198088,NUP62CL,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 24.2268% (minimum 97%, Missing); salivary gland: 82.4561% (minimum 97%, Missing); skin: 34.3066% (minimum 95%, Missing)",-0.606934,-0.727732,0.01,0,80,unavailable,0,14.7,9,"esophagus: 14.7 nTPM (protected, limit 2); skin: 9 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198092,TMPRSS11F,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 24.2268% (minimum 70%, Missing); skin: 34.3066% (minimum 65%, Missing)",-0.306934,-0.457732,0.25,0,80,unavailable,0,14.7,9,"esophagus: 14.7 nTPM (protected, limit 2); skin: 9 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198092,TMPRSS11F,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 24.2268% (minimum 70%, Missing); skin: 34.3066% (minimum 65%, Missing)",-0.306934,-0.457732,0.25,0,80,unavailable,0,14.7,9,"esophagus: 14.7 nTPM (protected, limit 3); skin: 9 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198092,TMPRSS11F,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 24.2268% (minimum 70%, Missing); skin: 34.3066% (minimum 65%, Missing)",-0.306934,-0.457732,0.25,0,80,unavailable,0,14.7,9,"esophagus: 14.7 nTPM (protected, limit 3); skin: 9 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198092,TMPRSS11F,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 24.2268% (minimum 70%, Baseline (adaptation disabled)); skin: 34.3066% (minimum 65%, Baseline (adaptation disabled))",-0.306934,-0.457732,0.25,0,80,unavailable,0,14.7,9,"esophagus: 14.7 nTPM (protected, limit 3); skin: 9 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198092,TMPRSS11F,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000198129,DEFB107B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000198129,DEFB107B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000198129,DEFB107B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000198129,DEFB107B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000198129,DEFB107B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 96.5517% (minimum 99%, Missing)",0.05,0.03,-0.0244828,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198173,FAM47C,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.215517,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198173,FAM47C,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.215517,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198173,FAM47C,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.215517,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198173,FAM47C,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.215517,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198173,FAM47C,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.2500% (minimum 95%, Missing); bone marrow: 46.4286% (minimum 99%, Missing); colon: 92.8571% (minimum 97%, Missing); esophagus: 86.6667% (minimum 97%, Missing); liver: 86.6667% (minimum 99%, Missing); lung: 68.4211% (minimum 99%, Missing); lymph node: 19.6970% (minimum 97%, Missing); rectum: 92.8571% (minimum 97%, Missing); skeletal muscle: 92.8571% (minimum 99%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 86.6667% (minimum 99%, Missing); smooth muscle: 92.8571% (minimum 99%, Missing); spleen: 26.0000% (minimum 95%, Missing); stomach: 86.6667% (minimum 97%, Missing); thymus: 39.3939% (minimum 95%, Missing); urinary bladder: 56.5217% (minimum 97%, Missing)",-0.69,-0.77303,-0.525714,0,3,partial,1.5,5.3,3.7,"lymph node: 5.3 nTPM (protected, limit 2); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198178,CLEC4C,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 46.4286% (minimum 75%, Missing); lung: 68.4211% (minimum 75%, Missing); lymph node: 19.6970% (minimum 70%, Missing); spleen: 26.0000% (minimum 65%, Missing); thymus: 39.3939% (minimum 65%, Missing); urinary bladder: 56.5217% (minimum 70%, Missing)",-0.39,-0.50303,-0.285714,0,3,partial,1.5,5.3,3.7,"lymph node: 5.3 nTPM (protected, limit 2); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198178,CLEC4C,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 46.4286% (minimum 75%, Missing); lung: 68.4211% (minimum 75%, Missing); lymph node: 19.6970% (minimum 70%, Missing); spleen: 26.0000% (minimum 65%, Missing); thymus: 39.3939% (minimum 65%, Missing); urinary bladder: 56.5217% (minimum 70%, Missing)",-0.39,-0.50303,-0.285714,0,3,partial,1.5,5.3,3.7,"lymph node: 5.3 nTPM (protected, limit 3); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198178,CLEC4C,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 46.4286% (minimum 75%, Missing); lung: 68.4211% (minimum 75%, Missing); lymph node: 19.6970% (minimum 70%, Missing); spleen: 26.0000% (minimum 65%, Missing); thymus: 39.3939% (minimum 65%, Missing); urinary bladder: 56.5217% (minimum 70%, Missing)",-0.39,-0.50303,-0.285714,0,3,partial,1.5,5.3,3.7,"lymph node: 5.3 nTPM (protected, limit 3); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198178,CLEC4C,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 46.4286% (minimum 75%, Baseline (adaptation disabled)); lung: 68.4211% (minimum 75%, Baseline (adaptation disabled)); lymph node: 19.6970% (minimum 70%, Baseline (adaptation disabled)); spleen: 26.0000% (minimum 65%, Baseline (adaptation disabled)); thymus: 39.3939% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 56.5217% (minimum 70%, Baseline (adaptation disabled))",-0.39,-0.50303,-0.285714,0,3,partial,1.5,5.3,3.7,"lymph node: 5.3 nTPM (protected, limit 3); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198178,CLEC4C,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.0189% (minimum 95%, Missing); adrenal gland: 75.8621% (minimum 99%, Missing); amygdala: 75.2137% (minimum 99%, Missing); basal ganglia: 72.7273% (minimum 99%, Missing); bone marrow: 94.6237% (minimum 99%, Missing); cerebellum: 60.6897% (minimum 99%, Missing); cerebral cortex: 70.4000% (minimum 99%, Missing); choroid plexus: 72.1311% (minimum 99%, Missing); colon: 74.5763% (minimum 97%, Missing); duodenum: 84.6154% (minimum 99%, Missing); esophagus: 74.5763% (minimum 97%, Missing); heart muscle: 75.8621% (minimum 99%, Missing); hippocampal formation: 73.3333% (minimum 99%, Missing); hypothalamus: 72.7273% (minimum 99%, Missing); kidney: 73.3333% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 81.4815% (minimum 99%, Missing); lymph node: 77.8761% (minimum 97%, Missing); midbrain: 73.3333% (minimum 99%, Missing); pancreas: 76.5217% (minimum 99%, Missing); parathyroid gland: 63.7681% (minimum 97%, Missing); pituitary gland: 62.4113% (minimum 99%, Missing); rectum: 82.2430% (minimum 97%, Missing); retina: 65.6716% (minimum 99%, Missing); salivary gland: 79.2793% (minimum 97%, Missing); skeletal muscle: 83.0189% (minimum 99%, Missing); skin: 73.3333% (minimum 95%, Missing); small intestine: 77.1930% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spinal cord: 70.9677% (minimum 99%, Missing); spleen: 74.5763% (minimum 95%, Missing); stomach: 78.5714% (minimum 97%, Missing); thymus: 77.1930% (minimum 95%, Missing); thyroid gland: 69.8413% (minimum 95%, Missing); tongue: 83.0189% (minimum 97%, Missing); urinary bladder: 75.2137% (minimum 97%, Missing)",-0.251587,-0.332319,-0.383103,0,80,unavailable,5.7,5,3.8,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 2); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); amygdala: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198182,ZNF607,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 72.7273% (minimum 75%, Missing); cerebellum: 60.6897% (minimum 75%, Missing); cerebral cortex: 70.4000% (minimum 75%, Missing); choroid plexus: 72.1311% (minimum 75%, Missing); hippocampal formation: 73.3333% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); midbrain: 73.3333% (minimum 75%, Missing); parathyroid gland: 63.7681% (minimum 70%, Missing); pituitary gland: 62.4113% (minimum 75%, Missing); retina: 65.6716% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing)",0.0484127,-0.0623188,-0.143103,0,80,unavailable,5.7,5,3.8,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 2); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); amygdala: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198182,ZNF607,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 72.7273% (minimum 75%, Missing); cerebellum: 60.6897% (minimum 75%, Missing); cerebral cortex: 70.4000% (minimum 75%, Missing); choroid plexus: 72.1311% (minimum 75%, Missing); hippocampal formation: 73.3333% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); midbrain: 73.3333% (minimum 75%, Missing); parathyroid gland: 63.7681% (minimum 70%, Missing); pituitary gland: 62.4113% (minimum 75%, Missing); retina: 65.6716% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing)",0.0484127,-0.0623188,-0.143103,0,80,unavailable,5.7,5,3.8,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 3); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198182,ZNF607,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 72.7273% (minimum 75%, Missing); cerebellum: 60.6897% (minimum 75%, Missing); cerebral cortex: 70.4000% (minimum 75%, Missing); choroid plexus: 72.1311% (minimum 75%, Missing); hippocampal formation: 73.3333% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); midbrain: 73.3333% (minimum 75%, Missing); parathyroid gland: 63.7681% (minimum 70%, Missing); pituitary gland: 62.4113% (minimum 75%, Missing); retina: 65.6716% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing)",0.0484127,-0.0623188,-0.143103,0,80,unavailable,5.7,5,3.8,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 3); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198182,ZNF607,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 72.7273% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.6897% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.4000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.1311% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.7273% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.3333% (minimum 75%, Baseline (adaptation disabled)); midbrain: 73.3333% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 63.7681% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.4113% (minimum 75%, Baseline (adaptation disabled)); retina: 65.6716% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.9677% (minimum 75%, Baseline (adaptation disabled))",0.0484127,-0.0623188,-0.143103,0,80,unavailable,5.7,5,3.8,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 3); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198182,ZNF607,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lung: 25.3165% (minimum 99%, Missing); pituitary gland: 33.7079% (minimum 99%, Missing); salivary gland: 62.5000% (minimum 90%, Supported); thymus: 89.5522% (minimum 95%, Missing); urinary bladder: 86.9565% (minimum 90%, Supported)",-0.0544776,-0.275,-0.736835,0,2,partial,17.7,3.6,0.7,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1)",nasopharynx / respiratory epithelial cells: Medium (Supported),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198183,BPIFA1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lung: 25.3165% (minimum 75%, Missing); pituitary gland: 33.7079% (minimum 75%, Missing)",0.245522,0.025,-0.496835,0,2,partial,17.7,3.6,0.7,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1)",nasopharynx / respiratory epithelial cells: Medium (Supported),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198183,BPIFA1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lung: 25.3165% (minimum 75%, Missing); pituitary gland: 33.7079% (minimum 75%, Missing)",0.245522,0.025,-0.496835,0,2,partial,17.7,3.6,0.7,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1)",nasopharynx / respiratory epithelial cells: Medium (Supported),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198183,BPIFA1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lung: 25.3165% (minimum 75%, Missing); pituitary gland: 33.7079% (minimum 75%, Missing)",0.245522,0.025,-0.496835,0,2,partial,17.7,3.6,0.7,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1)",nasopharynx / respiratory epithelial cells: Medium (Supported),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198183,BPIFA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lung: 25.3165% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 33.7079% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 70%, Baseline (adaptation disabled))",0.245522,-0.075,-0.496835,0,2,partial,17.7,3.6,0.7,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3)",nasopharynx / respiratory epithelial cells: Medium (Supported),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198183,BPIFA1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 90%, Approved); adrenal gland: 64.8148% (minimum 98%, Approved); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 81.3953% (minimum 99%, Missing); bone marrow: 55.5556% (minimum 98%, Approved); cerebellum: 72.9167% (minimum 99%, Missing); cerebral cortex: 59.3220% (minimum 99%, Missing); choroid plexus: 89.7436% (minimum 99%, Missing); colon: 67.3077% (minimum 97%, Missing); duodenum: 72.9167% (minimum 99%, Missing); esophagus: 72.9167% (minimum 95%, Approved); heart muscle: 62.5000% (minimum 99%, Missing); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 81.3953% (minimum 99%, Missing); kidney: 63.6364% (minimum 99%, Missing); liver: 67.3077% (minimum 99%, Missing); lung: 66.0377% (minimum 98%, Approved); lymph node: 54.6875% (minimum 95%, Approved); midbrain: 83.3333% (minimum 99%, Missing); pancreas: 60.3448% (minimum 99%, Missing); parathyroid gland: 57.3770% (minimum 97%, Missing); pituitary gland: 76.0870% (minimum 99%, Missing); rectum: 70.0000% (minimum 97%, Missing); retina: 67.3077% (minimum 99%, Missing); salivary gland: 68.6275% (minimum 97%, Missing); skeletal muscle: 53.8462% (minimum 99%, Missing); skin: 68.6275% (minimum 90%, Approved); small intestine: 72.9167% (minimum 99%, Missing); smooth muscle: 62.5000% (minimum 98%, Approved); spinal cord: 79.5455% (minimum 99%, Missing); spleen: 53.0303% (minimum 90%, Approved); stomach: 59.3220% (minimum 97%, Missing); thymus: 61.4035% (minimum 95%, Missing); thyroid gland: 54.6875% (minimum 95%, Missing); tongue: 54.6875% (minimum 97%, Missing); urinary bladder: 67.3077% (minimum 97%, Missing)",-0.403125,-0.423125,-0.451538,0,5,partial,3,2.9,3.1,"skeletal muscle: 3 nTPM (vital, limit 1); tongue: 2.9 nTPM (protected, limit 2); bone marrow: 2.8 nTPM (vital, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198205,ZXDA,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.8148% (minimum 70%, Approved); bone marrow: 55.5556% (minimum 70%, Approved); cerebellum: 72.9167% (minimum 75%, Missing); cerebral cortex: 59.3220% (minimum 75%, Missing); colon: 67.3077% (minimum 70%, Missing); duodenum: 72.9167% (minimum 75%, Missing); heart muscle: 62.5000% (minimum 75%, Missing); kidney: 63.6364% (minimum 75%, Missing); liver: 67.3077% (minimum 75%, Missing); lung: 66.0377% (minimum 70%, Approved); lymph node: 54.6875% (minimum 65%, Approved); pancreas: 60.3448% (minimum 75%, Missing); parathyroid gland: 57.3770% (minimum 70%, Missing); retina: 67.3077% (minimum 75%, Missing); salivary gland: 68.6275% (minimum 70%, Missing); skeletal muscle: 53.8462% (minimum 75%, Missing); small intestine: 72.9167% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 70%, Approved); spleen: 53.0303% (minimum 60%, Approved); stomach: 59.3220% (minimum 70%, Missing); thymus: 61.4035% (minimum 65%, Missing); thyroid gland: 54.6875% (minimum 65%, Missing); tongue: 54.6875% (minimum 70%, Missing); urinary bladder: 67.3077% (minimum 70%, Missing)",-0.103125,-0.153125,-0.211538,0,5,partial,3,2.9,3.1,"skeletal muscle: 3 nTPM (vital, limit 1); tongue: 2.9 nTPM (protected, limit 2); bone marrow: 2.8 nTPM (vital, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198205,ZXDA,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.8148% (minimum 70%, Approved); bone marrow: 55.5556% (minimum 70%, Approved); cerebellum: 72.9167% (minimum 75%, Missing); cerebral cortex: 59.3220% (minimum 75%, Missing); colon: 67.3077% (minimum 70%, Missing); duodenum: 72.9167% (minimum 75%, Missing); heart muscle: 62.5000% (minimum 75%, Missing); kidney: 63.6364% (minimum 75%, Missing); liver: 67.3077% (minimum 75%, Missing); lung: 66.0377% (minimum 70%, Approved); lymph node: 54.6875% (minimum 65%, Approved); pancreas: 60.3448% (minimum 75%, Missing); parathyroid gland: 57.3770% (minimum 70%, Missing); retina: 67.3077% (minimum 75%, Missing); salivary gland: 68.6275% (minimum 70%, Missing); skeletal muscle: 53.8462% (minimum 75%, Missing); small intestine: 72.9167% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 70%, Approved); spleen: 53.0303% (minimum 60%, Approved); stomach: 59.3220% (minimum 70%, Missing); thymus: 61.4035% (minimum 65%, Missing); thyroid gland: 54.6875% (minimum 65%, Missing); tongue: 54.6875% (minimum 70%, Missing); urinary bladder: 67.3077% (minimum 70%, Missing)",-0.103125,-0.153125,-0.211538,0,5,partial,3,2.9,3.1,"skeletal muscle: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198205,ZXDA,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.8148% (minimum 70%, Approved); bone marrow: 55.5556% (minimum 70%, Approved); cerebellum: 72.9167% (minimum 75%, Missing); cerebral cortex: 59.3220% (minimum 75%, Missing); colon: 67.3077% (minimum 70%, Missing); duodenum: 72.9167% (minimum 75%, Missing); heart muscle: 62.5000% (minimum 75%, Missing); kidney: 63.6364% (minimum 75%, Missing); liver: 67.3077% (minimum 75%, Missing); lung: 66.0377% (minimum 70%, Approved); lymph node: 54.6875% (minimum 65%, Approved); pancreas: 60.3448% (minimum 75%, Missing); parathyroid gland: 57.3770% (minimum 70%, Missing); retina: 67.3077% (minimum 75%, Missing); salivary gland: 68.6275% (minimum 70%, Missing); skeletal muscle: 53.8462% (minimum 75%, Missing); small intestine: 72.9167% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 70%, Approved); spleen: 53.0303% (minimum 60%, Approved); stomach: 59.3220% (minimum 70%, Missing); thymus: 61.4035% (minimum 65%, Missing); thyroid gland: 54.6875% (minimum 65%, Missing); tongue: 54.6875% (minimum 70%, Missing); urinary bladder: 67.3077% (minimum 70%, Missing)",-0.103125,-0.153125,-0.211538,0,5,partial,3,2.9,3.1,"skeletal muscle: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198205,ZXDA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 64.8148% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 55.5556% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.9167% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 59.3220% (minimum 75%, Baseline (adaptation disabled)); colon: 67.3077% (minimum 70%, Baseline (adaptation disabled)); duodenum: 72.9167% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.6364% (minimum 75%, Baseline (adaptation disabled)); liver: 67.3077% (minimum 75%, Baseline (adaptation disabled)); lung: 66.0377% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.6875% (minimum 70%, Baseline (adaptation disabled)); pancreas: 60.3448% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.3770% (minimum 70%, Baseline (adaptation disabled)); retina: 67.3077% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.6275% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 53.8462% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.9167% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.0303% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.3220% (minimum 70%, Baseline (adaptation disabled)); thymus: 61.4035% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 54.6875% (minimum 65%, Baseline (adaptation disabled)); tongue: 54.6875% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.3077% (minimum 70%, Baseline (adaptation disabled))",-0.119697,-0.153125,-0.211538,0,5,partial,3,2.9,3.1,"skeletal muscle: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198205,ZXDA,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198283,OR5B21,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198283,OR5B21,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198283,OR5B21,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198283,OR5B21,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198283,OR5B21,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 74.5098% (minimum 95%, Missing); adrenal gland: 70.3704% (minimum 99%, Missing); amygdala: 76.0000% (minimum 99%, Missing); basal ganglia: 74.5098% (minimum 99%, Missing); bone marrow: 86.3636% (minimum 99%, Missing); cerebellum: 71.6981% (minimum 99%, Missing); cerebral cortex: 74.5098% (minimum 99%, Missing); choroid plexus: 82.6087% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 70.3704% (minimum 99%, Missing); esophagus: 67.8571% (minimum 97%, Missing); heart muscle: 74.5098% (minimum 99%, Missing); hippocampal formation: 74.5098% (minimum 99%, Missing); hypothalamus: 76.0000% (minimum 99%, Missing); kidney: 65.5172% (minimum 99%, Missing); liver: 69.0909% (minimum 99%, Missing); lung: 76.0000% (minimum 99%, Missing); lymph node: 55.0725% (minimum 97%, Missing); midbrain: 73.0769% (minimum 99%, Missing); pancreas: 48.7179% (minimum 99%, Missing); parathyroid gland: 73.0769% (minimum 97%, Missing); pituitary gland: 80.8511% (minimum 99%, Missing); rectum: 67.8571% (minimum 97%, Missing); retina: 77.5510% (minimum 99%, Missing); salivary gland: 69.0909% (minimum 97%, Missing); skeletal muscle: 55.8824% (minimum 99%, Missing); skin: 54.2857% (minimum 95%, Missing); small intestine: 71.6981% (minimum 99%, Missing); smooth muscle: 73.0769% (minimum 99%, Missing); spinal cord: 73.0769% (minimum 99%, Missing); spleen: 64.4068% (minimum 95%, Missing); stomach: 63.3333% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 69.0909% (minimum 95%, Missing); tongue: 61.2903% (minimum 97%, Missing); urinary bladder: 70.3704% (minimum 97%, Missing)",-0.407143,-0.419275,-0.502821,0,80,unavailable,4,3.1,3.2,"pancreas: 4 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198298,ZNF485,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.3704% (minimum 75%, Missing); basal ganglia: 74.5098% (minimum 75%, Missing); cerebellum: 71.6981% (minimum 75%, Missing); cerebral cortex: 74.5098% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 70.3704% (minimum 75%, Missing); esophagus: 67.8571% (minimum 70%, Missing); heart muscle: 74.5098% (minimum 75%, Missing); hippocampal formation: 74.5098% (minimum 75%, Missing); kidney: 65.5172% (minimum 75%, Missing); liver: 69.0909% (minimum 75%, Missing); lymph node: 55.0725% (minimum 70%, Missing); midbrain: 73.0769% (minimum 75%, Missing); pancreas: 48.7179% (minimum 75%, Missing); rectum: 67.8571% (minimum 70%, Missing); salivary gland: 69.0909% (minimum 70%, Missing); skeletal muscle: 55.8824% (minimum 75%, Missing); skin: 54.2857% (minimum 65%, Missing); small intestine: 71.6981% (minimum 75%, Missing); smooth muscle: 73.0769% (minimum 75%, Missing); spinal cord: 73.0769% (minimum 75%, Missing); spleen: 64.4068% (minimum 65%, Missing); stomach: 63.3333% (minimum 70%, Missing); tongue: 61.2903% (minimum 70%, Missing)",-0.107143,-0.149275,-0.262821,0,80,unavailable,4,3.1,3.2,"pancreas: 4 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198298,ZNF485,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.3704% (minimum 75%, Missing); basal ganglia: 74.5098% (minimum 75%, Missing); cerebellum: 71.6981% (minimum 75%, Missing); cerebral cortex: 74.5098% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 70.3704% (minimum 75%, Missing); esophagus: 67.8571% (minimum 70%, Missing); heart muscle: 74.5098% (minimum 75%, Missing); hippocampal formation: 74.5098% (minimum 75%, Missing); kidney: 65.5172% (minimum 75%, Missing); liver: 69.0909% (minimum 75%, Missing); lymph node: 55.0725% (minimum 70%, Missing); midbrain: 73.0769% (minimum 75%, Missing); pancreas: 48.7179% (minimum 75%, Missing); rectum: 67.8571% (minimum 70%, Missing); salivary gland: 69.0909% (minimum 70%, Missing); skeletal muscle: 55.8824% (minimum 75%, Missing); skin: 54.2857% (minimum 65%, Missing); small intestine: 71.6981% (minimum 75%, Missing); smooth muscle: 73.0769% (minimum 75%, Missing); spinal cord: 73.0769% (minimum 75%, Missing); spleen: 64.4068% (minimum 65%, Missing); stomach: 63.3333% (minimum 70%, Missing); tongue: 61.2903% (minimum 70%, Missing)",-0.107143,-0.149275,-0.262821,0,80,unavailable,4,3.1,3.2,"pancreas: 4 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198298,ZNF485,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.3704% (minimum 75%, Missing); basal ganglia: 74.5098% (minimum 75%, Missing); cerebellum: 71.6981% (minimum 75%, Missing); cerebral cortex: 74.5098% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 70.3704% (minimum 75%, Missing); esophagus: 67.8571% (minimum 70%, Missing); heart muscle: 74.5098% (minimum 75%, Missing); hippocampal formation: 74.5098% (minimum 75%, Missing); kidney: 65.5172% (minimum 75%, Missing); liver: 69.0909% (minimum 75%, Missing); lymph node: 55.0725% (minimum 70%, Missing); midbrain: 73.0769% (minimum 75%, Missing); pancreas: 48.7179% (minimum 75%, Missing); rectum: 67.8571% (minimum 70%, Missing); salivary gland: 69.0909% (minimum 70%, Missing); skeletal muscle: 55.8824% (minimum 75%, Missing); skin: 54.2857% (minimum 65%, Missing); small intestine: 71.6981% (minimum 75%, Missing); smooth muscle: 73.0769% (minimum 75%, Missing); spinal cord: 73.0769% (minimum 75%, Missing); spleen: 64.4068% (minimum 65%, Missing); stomach: 63.3333% (minimum 70%, Missing); tongue: 61.2903% (minimum 70%, Missing)",-0.107143,-0.149275,-0.262821,0,80,unavailable,4,3.1,3.2,"pancreas: 4 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198298,ZNF485,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.3704% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.5098% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 71.6981% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.5098% (minimum 75%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 70%, Baseline (adaptation disabled)); duodenum: 70.3704% (minimum 75%, Baseline (adaptation disabled)); esophagus: 67.8571% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 74.5098% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 74.5098% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.5172% (minimum 75%, Baseline (adaptation disabled)); liver: 69.0909% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.0725% (minimum 70%, Baseline (adaptation disabled)); midbrain: 73.0769% (minimum 75%, Baseline (adaptation disabled)); pancreas: 48.7179% (minimum 75%, Baseline (adaptation disabled)); rectum: 67.8571% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 69.0909% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.8824% (minimum 75%, Baseline (adaptation disabled)); skin: 54.2857% (minimum 65%, Baseline (adaptation disabled)); small intestine: 71.6981% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.0769% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.0769% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.4068% (minimum 65%, Baseline (adaptation disabled)); stomach: 63.3333% (minimum 70%, Baseline (adaptation disabled)); tongue: 61.2903% (minimum 70%, Baseline (adaptation disabled))",-0.107143,-0.149275,-0.262821,0,80,unavailable,4,3.1,3.2,"pancreas: 4 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198298,ZNF485,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.00232246,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000198326,TMEM239,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.242322,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000198326,TMEM239,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.242322,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000198326,TMEM239,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.242322,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000198326,TMEM239,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.242322,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000198326,TMEM239,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.6610% (minimum 95%, Missing); adrenal gland: 82.4561% (minimum 99%, Missing); amygdala: 92.1569% (minimum 99%, Missing); basal ganglia: 90.3846% (minimum 99%, Missing); bone marrow: 78.3333% (minimum 99%, Missing); cerebellum: 97.9167% (minimum 99%, Missing); cerebral cortex: 87.0370% (minimum 99%, Missing); choroid plexus: 92.1569% (minimum 99%, Missing); colon: 73.4375% (minimum 97%, Missing); duodenum: 73.4375% (minimum 99%, Missing); esophagus: 81.0345% (minimum 97%, Missing); heart muscle: 88.6792% (minimum 99%, Missing); hippocampal formation: 92.1569% (minimum 99%, Missing); hypothalamus: 92.1569% (minimum 99%, Missing); kidney: 79.6610% (minimum 99%, Missing); liver: 88.6792% (minimum 99%, Missing); lung: 78.3333% (minimum 99%, Missing); lymph node: 69.1176% (minimum 97%, Missing); midbrain: 90.3846% (minimum 99%, Missing); pancreas: 79.6610% (minimum 99%, Missing); parathyroid gland: 67.1429% (minimum 97%, Missing); pituitary gland: 88.6792% (minimum 99%, Missing); rectum: 73.4375% (minimum 97%, Missing); retina: 88.6792% (minimum 99%, Missing); salivary gland: 79.6610% (minimum 97%, Missing); skeletal muscle: 94.0000% (minimum 99%, Missing); skin: 71.2121% (minimum 95%, Missing); small intestine: 74.6032% (minimum 99%, Missing); smooth muscle: 83.9286% (minimum 99%, Missing); spinal cord: 88.6792% (minimum 99%, Missing); spleen: 72.3077% (minimum 95%, Missing); stomach: 71.2121% (minimum 97%, Missing); thymus: 69.1176% (minimum 95%, Missing); thyroid gland: 72.3077% (minimum 95%, Missing); tongue: 90.3846% (minimum 97%, Missing); urinary bladder: 78.3333% (minimum 97%, Missing)",-0.258824,-0.298571,-0.255625,0,80,unavailable,1.7,2.3,2.1,"parathyroid gland: 2.3 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198346,ZNF813,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 73.4375% (minimum 75%, Missing); lymph node: 69.1176% (minimum 70%, Missing); parathyroid gland: 67.1429% (minimum 70%, Missing); small intestine: 74.6032% (minimum 75%, Missing)",0.0411765,-0.0285714,-0.015625,0,80,unavailable,1.7,2.3,2.1,"parathyroid gland: 2.3 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198346,ZNF813,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 73.4375% (minimum 75%, Missing); lymph node: 69.1176% (minimum 70%, Missing); parathyroid gland: 67.1429% (minimum 70%, Missing); small intestine: 74.6032% (minimum 75%, Missing)",0.0411765,-0.0285714,-0.015625,0,80,unavailable,1.7,2.3,2.1,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198346,ZNF813,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 73.4375% (minimum 75%, Missing); lymph node: 69.1176% (minimum 70%, Missing); parathyroid gland: 67.1429% (minimum 70%, Missing); small intestine: 74.6032% (minimum 75%, Missing)",0.0411765,-0.0285714,-0.015625,0,80,unavailable,1.7,2.3,2.1,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198346,ZNF813,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 73.4375% (minimum 75%, Baseline (adaptation disabled)); lymph node: 69.1176% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 67.1429% (minimum 70%, Baseline (adaptation disabled)); small intestine: 74.6032% (minimum 75%, Baseline (adaptation disabled))",0.0411765,-0.0285714,-0.015625,0,80,unavailable,1.7,2.3,2.1,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198346,ZNF813,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); skin: 2.2472% (minimum 95%, Missing)",-0.927528,0.03,0.01,0,80,unavailable,0,0,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198390,KRTAP13-1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 2.2472% (minimum 65%, Missing)",-0.627528,0.3,0.25,0,80,unavailable,0,0,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198390,KRTAP13-1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 2.2472% (minimum 65%, Missing)",-0.627528,0.3,0.25,0,80,unavailable,0,0,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198390,KRTAP13-1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 2.2472% (minimum 65%, Missing)",-0.627528,0.3,0.25,0,80,unavailable,0,0,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198390,KRTAP13-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 2.2472% (minimum 65%, Baseline (adaptation disabled))",-0.627528,0.3,0.25,0,80,unavailable,0,0,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198390,KRTAP13-1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.6078% (minimum 95%, Missing); adrenal gland: 75.5319% (minimum 99%, Missing); amygdala: 69.6078% (minimum 99%, Missing); basal ganglia: 70.2970% (minimum 99%, Missing); bone marrow: 87.6543% (minimum 99%, Missing); cerebellum: 63.9640% (minimum 99%, Missing); cerebral cortex: 65.7407% (minimum 99%, Missing); choroid plexus: 81.6092% (minimum 99%, Missing); colon: 77.1739% (minimum 97%, Missing); duodenum: 84.5238% (minimum 99%, Missing); esophagus: 83.5294% (minimum 97%, Missing); heart muscle: 78.0220% (minimum 99%, Missing); hippocampal formation: 68.9320% (minimum 99%, Missing); hypothalamus: 70.2970% (minimum 99%, Missing); kidney: 72.4490% (minimum 99%, Missing); liver: 73.9583% (minimum 99%, Missing); lung: 72.4490% (minimum 99%, Missing); lymph node: 80.6818% (minimum 97%, Missing); midbrain: 68.9320% (minimum 99%, Missing); pancreas: 73.9583% (minimum 99%, Missing); parathyroid gland: 64.5455% (minimum 97%, Missing); pituitary gland: 73.1959% (minimum 99%, Missing); rectum: 83.5294% (minimum 97%, Missing); retina: 64.5455% (minimum 99%, Missing); salivary gland: 88.7500% (minimum 97%, Missing); skeletal muscle: 77.1739% (minimum 99%, Missing); skin: 89.8734% (minimum 95%, Missing); small intestine: 85.5422% (minimum 99%, Missing); smooth muscle: 73.9583% (minimum 99%, Missing); spinal cord: 67.6190% (minimum 99%, Missing); spleen: 75.5319% (minimum 95%, Missing); stomach: 81.6092% (minimum 97%, Missing); thymus: 72.4490% (minimum 95%, Missing); thyroid gland: 68.2692% (minimum 95%, Missing); tongue: 69.6078% (minimum 97%, Missing); urinary bladder: 78.0220% (minimum 97%, Missing)",-0.267308,-0.324545,-0.35036,0,80,unavailable,4,3.9,3.3,"cerebellum: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198440,ZNF583,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.6078% (minimum 75%, Missing); basal ganglia: 70.2970% (minimum 75%, Missing); cerebellum: 63.9640% (minimum 75%, Missing); cerebral cortex: 65.7407% (minimum 75%, Missing); hippocampal formation: 68.9320% (minimum 75%, Missing); hypothalamus: 70.2970% (minimum 75%, Missing); kidney: 72.4490% (minimum 75%, Missing); liver: 73.9583% (minimum 75%, Missing); lung: 72.4490% (minimum 75%, Missing); midbrain: 68.9320% (minimum 75%, Missing); pancreas: 73.9583% (minimum 75%, Missing); parathyroid gland: 64.5455% (minimum 70%, Missing); pituitary gland: 73.1959% (minimum 75%, Missing); retina: 64.5455% (minimum 75%, Missing); smooth muscle: 73.9583% (minimum 75%, Missing); spinal cord: 67.6190% (minimum 75%, Missing); tongue: 69.6078% (minimum 70%, Missing)",0.0326923,-0.0545455,-0.11036,0,80,unavailable,4,3.9,3.3,"cerebellum: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198440,ZNF583,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.6078% (minimum 75%, Missing); basal ganglia: 70.2970% (minimum 75%, Missing); cerebellum: 63.9640% (minimum 75%, Missing); cerebral cortex: 65.7407% (minimum 75%, Missing); hippocampal formation: 68.9320% (minimum 75%, Missing); hypothalamus: 70.2970% (minimum 75%, Missing); kidney: 72.4490% (minimum 75%, Missing); liver: 73.9583% (minimum 75%, Missing); lung: 72.4490% (minimum 75%, Missing); midbrain: 68.9320% (minimum 75%, Missing); pancreas: 73.9583% (minimum 75%, Missing); parathyroid gland: 64.5455% (minimum 70%, Missing); pituitary gland: 73.1959% (minimum 75%, Missing); retina: 64.5455% (minimum 75%, Missing); smooth muscle: 73.9583% (minimum 75%, Missing); spinal cord: 67.6190% (minimum 75%, Missing); tongue: 69.6078% (minimum 70%, Missing)",0.0326923,-0.0545455,-0.11036,0,80,unavailable,4,3.9,3.3,"cerebellum: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198440,ZNF583,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.6078% (minimum 75%, Missing); basal ganglia: 70.2970% (minimum 75%, Missing); cerebellum: 63.9640% (minimum 75%, Missing); cerebral cortex: 65.7407% (minimum 75%, Missing); hippocampal formation: 68.9320% (minimum 75%, Missing); hypothalamus: 70.2970% (minimum 75%, Missing); kidney: 72.4490% (minimum 75%, Missing); liver: 73.9583% (minimum 75%, Missing); lung: 72.4490% (minimum 75%, Missing); midbrain: 68.9320% (minimum 75%, Missing); pancreas: 73.9583% (minimum 75%, Missing); parathyroid gland: 64.5455% (minimum 70%, Missing); pituitary gland: 73.1959% (minimum 75%, Missing); retina: 64.5455% (minimum 75%, Missing); smooth muscle: 73.9583% (minimum 75%, Missing); spinal cord: 67.6190% (minimum 75%, Missing); tongue: 69.6078% (minimum 70%, Missing)",0.0326923,-0.0545455,-0.11036,0,80,unavailable,4,3.9,3.3,"cerebellum: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198440,ZNF583,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.6078% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.2970% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 63.9640% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.7407% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.9320% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 70.2970% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.4490% (minimum 75%, Baseline (adaptation disabled)); liver: 73.9583% (minimum 75%, Baseline (adaptation disabled)); lung: 72.4490% (minimum 75%, Baseline (adaptation disabled)); midbrain: 68.9320% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.9583% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.5455% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 73.1959% (minimum 75%, Baseline (adaptation disabled)); retina: 64.5455% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.9583% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.6190% (minimum 75%, Baseline (adaptation disabled)); tongue: 69.6078% (minimum 70%, Baseline (adaptation disabled))",0.0326923,-0.0545455,-0.11036,0,80,unavailable,4,3.9,3.3,"cerebellum: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198440,ZNF583,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198445,CCT8L2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198445,CCT8L2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198445,CCT8L2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198445,CCT8L2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198445,CCT8L2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7363% (minimum 95%, Missing); adrenal gland: 56.8627% (minimum 99%, Missing); amygdala: 54.2056% (minimum 99%, Missing); basal ganglia: 58.0000% (minimum 99%, Missing); bone marrow: 75.3247% (minimum 99%, Missing); cerebellum: 49.5726% (minimum 99%, Missing); cerebral cortex: 57.4257% (minimum 99%, Missing); choroid plexus: 63.7363% (minimum 99%, Missing); colon: 62.3656% (minimum 97%, Missing); duodenum: 79.4521% (minimum 99%, Missing); esophagus: 69.8795% (minimum 97%, Missing); heart muscle: 65.9091% (minimum 99%, Missing); hippocampal formation: 55.7692% (minimum 99%, Missing); hypothalamus: 51.7857% (minimum 99%, Missing); kidney: 65.1685% (minimum 99%, Missing); liver: 73.4177% (minimum 99%, Missing); lung: 69.0476% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 52.7273% (minimum 99%, Missing); pancreas: 65.9091% (minimum 99%, Missing); parathyroid gland: 49.5726% (minimum 97%, Missing); pituitary gland: 58.0000% (minimum 99%, Missing); rectum: 76.3158% (minimum 97%, Missing); retina: 40.8451% (minimum 99%, Missing); salivary gland: 62.3656% (minimum 97%, Missing); skeletal muscle: 41.7266% (minimum 99%, Missing); skin: 63.0435% (minimum 95%, Missing); small intestine: 71.6049% (minimum 99%, Missing); smooth muscle: 57.4257% (minimum 99%, Missing); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 58.5859% (minimum 95%, Missing); stomach: 67.4419% (minimum 97%, Missing); thymus: 64.4444% (minimum 95%, Missing); thyroid gland: 52.2523% (minimum 95%, Missing); tongue: 57.4257% (minimum 97%, Missing); urinary bladder: 61.7021% (minimum 97%, Missing)",-0.427477,-0.474274,-0.581549,0,80,unavailable,8.4,5.9,5.3,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198453,ZNF568,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7363% (minimum 65%, Missing); adrenal gland: 56.8627% (minimum 75%, Missing); amygdala: 54.2056% (minimum 75%, Missing); basal ganglia: 58.0000% (minimum 75%, Missing); cerebellum: 49.5726% (minimum 75%, Missing); cerebral cortex: 57.4257% (minimum 75%, Missing); choroid plexus: 63.7363% (minimum 75%, Missing); colon: 62.3656% (minimum 70%, Missing); esophagus: 69.8795% (minimum 70%, Missing); heart muscle: 65.9091% (minimum 75%, Missing); hippocampal formation: 55.7692% (minimum 75%, Missing); hypothalamus: 51.7857% (minimum 75%, Missing); kidney: 65.1685% (minimum 75%, Missing); liver: 73.4177% (minimum 75%, Missing); lung: 69.0476% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 52.7273% (minimum 75%, Missing); pancreas: 65.9091% (minimum 75%, Missing); parathyroid gland: 49.5726% (minimum 70%, Missing); pituitary gland: 58.0000% (minimum 75%, Missing); retina: 40.8451% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); skeletal muscle: 41.7266% (minimum 75%, Missing); skin: 63.0435% (minimum 65%, Missing); small intestine: 71.6049% (minimum 75%, Missing); smooth muscle: 57.4257% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 58.5859% (minimum 65%, Missing); stomach: 67.4419% (minimum 70%, Missing); thymus: 64.4444% (minimum 65%, Missing); thyroid gland: 52.2523% (minimum 65%, Missing); tongue: 57.4257% (minimum 70%, Missing); urinary bladder: 61.7021% (minimum 70%, Missing)",-0.127477,-0.204274,-0.341549,0,80,unavailable,8.4,5.9,5.3,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198453,ZNF568,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7363% (minimum 65%, Missing); adrenal gland: 56.8627% (minimum 75%, Missing); amygdala: 54.2056% (minimum 75%, Missing); basal ganglia: 58.0000% (minimum 75%, Missing); cerebellum: 49.5726% (minimum 75%, Missing); cerebral cortex: 57.4257% (minimum 75%, Missing); choroid plexus: 63.7363% (minimum 75%, Missing); colon: 62.3656% (minimum 70%, Missing); esophagus: 69.8795% (minimum 70%, Missing); heart muscle: 65.9091% (minimum 75%, Missing); hippocampal formation: 55.7692% (minimum 75%, Missing); hypothalamus: 51.7857% (minimum 75%, Missing); kidney: 65.1685% (minimum 75%, Missing); liver: 73.4177% (minimum 75%, Missing); lung: 69.0476% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 52.7273% (minimum 75%, Missing); pancreas: 65.9091% (minimum 75%, Missing); parathyroid gland: 49.5726% (minimum 70%, Missing); pituitary gland: 58.0000% (minimum 75%, Missing); retina: 40.8451% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); skeletal muscle: 41.7266% (minimum 75%, Missing); skin: 63.0435% (minimum 65%, Missing); small intestine: 71.6049% (minimum 75%, Missing); smooth muscle: 57.4257% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 58.5859% (minimum 65%, Missing); stomach: 67.4419% (minimum 70%, Missing); thymus: 64.4444% (minimum 65%, Missing); thyroid gland: 52.2523% (minimum 65%, Missing); tongue: 57.4257% (minimum 70%, Missing); urinary bladder: 61.7021% (minimum 70%, Missing)",-0.127477,-0.204274,-0.341549,0,80,unavailable,8.4,5.9,5.3,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); salivary gland: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198453,ZNF568,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7363% (minimum 65%, Missing); adrenal gland: 56.8627% (minimum 75%, Missing); amygdala: 54.2056% (minimum 75%, Missing); basal ganglia: 58.0000% (minimum 75%, Missing); cerebellum: 49.5726% (minimum 75%, Missing); cerebral cortex: 57.4257% (minimum 75%, Missing); choroid plexus: 63.7363% (minimum 75%, Missing); colon: 62.3656% (minimum 70%, Missing); esophagus: 69.8795% (minimum 70%, Missing); heart muscle: 65.9091% (minimum 75%, Missing); hippocampal formation: 55.7692% (minimum 75%, Missing); hypothalamus: 51.7857% (minimum 75%, Missing); kidney: 65.1685% (minimum 75%, Missing); liver: 73.4177% (minimum 75%, Missing); lung: 69.0476% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 52.7273% (minimum 75%, Missing); pancreas: 65.9091% (minimum 75%, Missing); parathyroid gland: 49.5726% (minimum 70%, Missing); pituitary gland: 58.0000% (minimum 75%, Missing); retina: 40.8451% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); skeletal muscle: 41.7266% (minimum 75%, Missing); skin: 63.0435% (minimum 65%, Missing); small intestine: 71.6049% (minimum 75%, Missing); smooth muscle: 57.4257% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 58.5859% (minimum 65%, Missing); stomach: 67.4419% (minimum 70%, Missing); thymus: 64.4444% (minimum 65%, Missing); thyroid gland: 52.2523% (minimum 65%, Missing); tongue: 57.4257% (minimum 70%, Missing); urinary bladder: 61.7021% (minimum 70%, Missing)",-0.127477,-0.204274,-0.341549,0,80,unavailable,8.4,5.9,5.3,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); salivary gland: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198453,ZNF568,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7363% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 56.8627% (minimum 75%, Baseline (adaptation disabled)); amygdala: 54.2056% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 49.5726% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 57.4257% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 63.7363% (minimum 75%, Baseline (adaptation disabled)); colon: 62.3656% (minimum 70%, Baseline (adaptation disabled)); esophagus: 69.8795% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 65.9091% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.7692% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 51.7857% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.1685% (minimum 75%, Baseline (adaptation disabled)); liver: 73.4177% (minimum 75%, Baseline (adaptation disabled)); lung: 69.0476% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); midbrain: 52.7273% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.9091% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.5726% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 40.8451% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 62.3656% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 41.7266% (minimum 75%, Baseline (adaptation disabled)); skin: 63.0435% (minimum 65%, Baseline (adaptation disabled)); small intestine: 71.6049% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.4257% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 58.5859% (minimum 65%, Baseline (adaptation disabled)); stomach: 67.4419% (minimum 70%, Baseline (adaptation disabled)); thymus: 64.4444% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.2523% (minimum 65%, Baseline (adaptation disabled)); tongue: 57.4257% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.7021% (minimum 70%, Baseline (adaptation disabled))",-0.127477,-0.204274,-0.341549,0,80,unavailable,8.4,5.9,5.3,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); salivary gland: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198453,ZNF568,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.8966% (minimum 95%, Missing); adrenal gland: 65.9864% (minimum 99%, Missing); amygdala: 72.9323% (minimum 99%, Missing); basal ganglia: 65.5405% (minimum 99%, Missing); bone marrow: 59.1463% (minimum 99%, Missing); cerebellum: 58.7879% (minimum 99%, Missing); cerebral cortex: 69.2857% (minimum 99%, Missing); choroid plexus: 70.8029% (minimum 99%, Missing); colon: 53.8889% (minimum 97%, Missing); duodenum: 54.8023% (minimum 99%, Missing); esophagus: 61.7834% (minimum 97%, Missing); heart muscle: 62.5806% (minimum 99%, Missing); hippocampal formation: 69.7842% (minimum 99%, Missing); hypothalamus: 68.3099% (minimum 99%, Missing); kidney: 60.6250% (minimum 99%, Missing); liver: 61.3924% (minimum 99%, Missing); lung: 61.7834% (minimum 99%, Missing); lymph node: 64.6667% (minimum 97%, Uncertain); midbrain: 75.1938% (minimum 99%, Missing); pancreas: 52.4324% (minimum 99%, Missing); parathyroid gland: 66.8966% (minimum 97%, Missing); pituitary gland: 46.4115% (minimum 99%, Missing); rectum: 43.3036% (minimum 97%, Missing); retina: 46.4115% (minimum 99%, Missing); salivary gland: 45.3271% (minimum 97%, Missing); skeletal muscle: 69.2857% (minimum 99%, Missing); skin: 62.5806% (minimum 95%, Missing); small intestine: 55.7471% (minimum 99%, Missing); smooth muscle: 64.6667% (minimum 99%, Missing); spinal cord: 69.2857% (minimum 99%, Missing); spleen: 61.7834% (minimum 95%, Uncertain); stomach: 52.7174% (minimum 97%, Missing); thymus: 64.6667% (minimum 95%, Missing); thyroid gland: 56.3953% (minimum 95%, Missing); tongue: 70.8029% (minimum 97%, Missing); urinary bladder: 61.7834% (minimum 97%, Missing)",-0.386047,-0.536964,-0.525885,0,3,partial,11.2,12.7,7.5,"rectum: 12.7 nTPM (protected, limit 2); salivary gland: 11.7 nTPM (protected, limit 2); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); esophagus: 6 nTPM (protected, limit 2); spleen: 6 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); parathyroid gland: 4.8 nTPM (protected, limit 2); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198466,ZNF587,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.9864% (minimum 75%, Missing); amygdala: 72.9323% (minimum 75%, Missing); basal ganglia: 65.5405% (minimum 75%, Missing); bone marrow: 59.1463% (minimum 75%, Missing); cerebellum: 58.7879% (minimum 75%, Missing); cerebral cortex: 69.2857% (minimum 75%, Missing); choroid plexus: 70.8029% (minimum 75%, Missing); colon: 53.8889% (minimum 70%, Missing); duodenum: 54.8023% (minimum 75%, Missing); esophagus: 61.7834% (minimum 70%, Missing); heart muscle: 62.5806% (minimum 75%, Missing); hippocampal formation: 69.7842% (minimum 75%, Missing); hypothalamus: 68.3099% (minimum 75%, Missing); kidney: 60.6250% (minimum 75%, Missing); liver: 61.3924% (minimum 75%, Missing); lung: 61.7834% (minimum 75%, Missing); lymph node: 64.6667% (minimum 70%, Uncertain); pancreas: 52.4324% (minimum 75%, Missing); parathyroid gland: 66.8966% (minimum 70%, Missing); pituitary gland: 46.4115% (minimum 75%, Missing); rectum: 43.3036% (minimum 70%, Missing); retina: 46.4115% (minimum 75%, Missing); salivary gland: 45.3271% (minimum 70%, Missing); skeletal muscle: 69.2857% (minimum 75%, Missing); skin: 62.5806% (minimum 65%, Missing); small intestine: 55.7471% (minimum 75%, Missing); smooth muscle: 64.6667% (minimum 75%, Missing); spinal cord: 69.2857% (minimum 75%, Missing); spleen: 61.7834% (minimum 65%, Uncertain); stomach: 52.7174% (minimum 70%, Missing); thymus: 64.6667% (minimum 65%, Missing); thyroid gland: 56.3953% (minimum 65%, Missing); urinary bladder: 61.7834% (minimum 70%, Missing)",-0.0860465,-0.266964,-0.285885,0,3,partial,11.2,12.7,7.5,"rectum: 12.7 nTPM (protected, limit 2); salivary gland: 11.7 nTPM (protected, limit 2); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); esophagus: 6 nTPM (protected, limit 2); spleen: 6 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); parathyroid gland: 4.8 nTPM (protected, limit 2); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198466,ZNF587,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.9864% (minimum 75%, Missing); amygdala: 72.9323% (minimum 75%, Missing); basal ganglia: 65.5405% (minimum 75%, Missing); bone marrow: 59.1463% (minimum 75%, Missing); cerebellum: 58.7879% (minimum 75%, Missing); cerebral cortex: 69.2857% (minimum 75%, Missing); choroid plexus: 70.8029% (minimum 75%, Missing); colon: 53.8889% (minimum 70%, Missing); duodenum: 54.8023% (minimum 75%, Missing); esophagus: 61.7834% (minimum 70%, Missing); heart muscle: 62.5806% (minimum 75%, Missing); hippocampal formation: 69.7842% (minimum 75%, Missing); hypothalamus: 68.3099% (minimum 75%, Missing); kidney: 60.6250% (minimum 75%, Missing); liver: 61.3924% (minimum 75%, Missing); lung: 61.7834% (minimum 75%, Missing); lymph node: 64.6667% (minimum 70%, Uncertain); pancreas: 52.4324% (minimum 75%, Missing); parathyroid gland: 66.8966% (minimum 70%, Missing); pituitary gland: 46.4115% (minimum 75%, Missing); rectum: 43.3036% (minimum 70%, Missing); retina: 46.4115% (minimum 75%, Missing); salivary gland: 45.3271% (minimum 70%, Missing); skeletal muscle: 69.2857% (minimum 75%, Missing); skin: 62.5806% (minimum 65%, Missing); small intestine: 55.7471% (minimum 75%, Missing); smooth muscle: 64.6667% (minimum 75%, Missing); spinal cord: 69.2857% (minimum 75%, Missing); spleen: 61.7834% (minimum 65%, Uncertain); stomach: 52.7174% (minimum 70%, Missing); thymus: 64.6667% (minimum 65%, Missing); thyroid gland: 56.3953% (minimum 65%, Missing); urinary bladder: 61.7834% (minimum 70%, Missing)",-0.0860465,-0.266964,-0.285885,0,3,partial,11.2,12.7,7.5,"rectum: 12.7 nTPM (protected, limit 3); salivary gland: 11.7 nTPM (protected, limit 3); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 3); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); esophagus: 6 nTPM (protected, limit 3); spleen: 6 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); parathyroid gland: 4.8 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198466,ZNF587,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.9864% (minimum 75%, Missing); amygdala: 72.9323% (minimum 75%, Missing); basal ganglia: 65.5405% (minimum 75%, Missing); bone marrow: 59.1463% (minimum 75%, Missing); cerebellum: 58.7879% (minimum 75%, Missing); cerebral cortex: 69.2857% (minimum 75%, Missing); choroid plexus: 70.8029% (minimum 75%, Missing); colon: 53.8889% (minimum 70%, Missing); duodenum: 54.8023% (minimum 75%, Missing); esophagus: 61.7834% (minimum 70%, Missing); heart muscle: 62.5806% (minimum 75%, Missing); hippocampal formation: 69.7842% (minimum 75%, Missing); hypothalamus: 68.3099% (minimum 75%, Missing); kidney: 60.6250% (minimum 75%, Missing); liver: 61.3924% (minimum 75%, Missing); lung: 61.7834% (minimum 75%, Missing); lymph node: 64.6667% (minimum 70%, Uncertain); pancreas: 52.4324% (minimum 75%, Missing); parathyroid gland: 66.8966% (minimum 70%, Missing); pituitary gland: 46.4115% (minimum 75%, Missing); rectum: 43.3036% (minimum 70%, Missing); retina: 46.4115% (minimum 75%, Missing); salivary gland: 45.3271% (minimum 70%, Missing); skeletal muscle: 69.2857% (minimum 75%, Missing); skin: 62.5806% (minimum 65%, Missing); small intestine: 55.7471% (minimum 75%, Missing); smooth muscle: 64.6667% (minimum 75%, Missing); spinal cord: 69.2857% (minimum 75%, Missing); spleen: 61.7834% (minimum 65%, Uncertain); stomach: 52.7174% (minimum 70%, Missing); thymus: 64.6667% (minimum 65%, Missing); thyroid gland: 56.3953% (minimum 65%, Missing); urinary bladder: 61.7834% (minimum 70%, Missing)",-0.0860465,-0.266964,-0.285885,0,3,partial,11.2,12.7,7.5,"rectum: 12.7 nTPM (protected, limit 3); salivary gland: 11.7 nTPM (protected, limit 3); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 3); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); esophagus: 6 nTPM (protected, limit 3); spleen: 6 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); parathyroid gland: 4.8 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198466,ZNF587,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.9864% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.9323% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.5405% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 59.1463% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 58.7879% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 69.2857% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.8029% (minimum 75%, Baseline (adaptation disabled)); colon: 53.8889% (minimum 70%, Baseline (adaptation disabled)); duodenum: 54.8023% (minimum 75%, Baseline (adaptation disabled)); esophagus: 61.7834% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 62.5806% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 69.7842% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.3099% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.6250% (minimum 75%, Baseline (adaptation disabled)); liver: 61.3924% (minimum 75%, Baseline (adaptation disabled)); lung: 61.7834% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.6667% (minimum 70%, Baseline (adaptation disabled)); pancreas: 52.4324% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.8966% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 46.4115% (minimum 75%, Baseline (adaptation disabled)); rectum: 43.3036% (minimum 70%, Baseline (adaptation disabled)); retina: 46.4115% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 45.3271% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 69.2857% (minimum 75%, Baseline (adaptation disabled)); skin: 62.5806% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.7471% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.2857% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.7834% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.7174% (minimum 70%, Baseline (adaptation disabled)); thymus: 64.6667% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.3953% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 61.7834% (minimum 70%, Baseline (adaptation disabled))",-0.0860465,-0.266964,-0.285885,0,3,partial,11.2,12.7,7.5,"rectum: 12.7 nTPM (protected, limit 3); salivary gland: 11.7 nTPM (protected, limit 3); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 3); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); esophagus: 6 nTPM (protected, limit 3); spleen: 6 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); parathyroid gland: 4.8 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198466,ZNF587,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 38.7097% (minimum 99%, Missing)",0.05,0.03,-0.602903,0,80,unavailable,1.9,0,0,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198471,RTP2,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 38.7097% (minimum 75%, Missing)",0.35,0.3,-0.362903,0,80,unavailable,1.9,0,0,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198471,RTP2,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 38.7097% (minimum 75%, Missing)",0.35,0.3,-0.362903,0,80,unavailable,1.9,0,0,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198471,RTP2,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 38.7097% (minimum 75%, Missing)",0.35,0.3,-0.362903,0,80,unavailable,1.9,0,0,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198471,RTP2,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 38.7097% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.362903,0,80,unavailable,1.9,0,0,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198471,RTP2,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.0588% (minimum 95%, Missing); adrenal gland: 71.5328% (minimum 99%, Missing); amygdala: 78.4000% (minimum 99%, Missing); basal ganglia: 80.3279% (minimum 99%, Missing); bone marrow: 47.8049% (minimum 99%, Missing); cerebellum: 72.5926% (minimum 99%, Missing); cerebral cortex: 62.8205% (minimum 99%, Missing); choroid plexus: 85.9649% (minimum 99%, Missing); colon: 69.5035% (minimum 97%, Missing); duodenum: 71.5328% (minimum 99%, Missing); esophagus: 73.6842% (minimum 97%, Missing); heart muscle: 67.1233% (minimum 99%, Missing); hippocampal formation: 78.4000% (minimum 99%, Missing); hypothalamus: 77.1654% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 85.9649% (minimum 99%, Missing); lung: 70.5036% (minimum 99%, Missing); lymph node: 54.7486% (minimum 97%, Missing); midbrain: 77.7778% (minimum 99%, Missing); pancreas: 77.1654% (minimum 99%, Missing); parathyroid gland: 60.4938% (minimum 97%, Missing); pituitary gland: 79.6748% (minimum 99%, Missing); rectum: 65.7718% (minimum 97%, Missing); retina: 59.3939% (minimum 99%, Missing); salivary gland: 73.6842% (minimum 97%, Missing); skeletal muscle: 70.5036% (minimum 99%, Missing); skin: 57.6471% (minimum 95%, Missing); small intestine: 70.0000% (minimum 99%, Missing); smooth muscle: 69.5035% (minimum 99%, Missing); spinal cord: 74.8092% (minimum 99%, Missing); spleen: 60.1227% (minimum 95%, Missing); stomach: 67.1233% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing); thyroid gland: 53.5519% (minimum 95%, Missing); tongue: 67.5862% (minimum 97%, Missing); urinary bladder: 73.6842% (minimum 97%, Missing)",-0.45,-0.422514,-0.511951,0,80,unavailable,10.7,8.1,9.8,"bone marrow: 10.7 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.5 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 2); skin: 7.2 nTPM (manageable, limit 5); retina: 6.7 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); parathyroid gland: 6.4 nTPM (protected, limit 2); cerebral cortex: 5.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 2); kidney: 4.9 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); heart muscle: 4.8 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198521,ZNF43,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.5328% (minimum 75%, Missing); bone marrow: 47.8049% (minimum 75%, Missing); cerebellum: 72.5926% (minimum 75%, Missing); cerebral cortex: 62.8205% (minimum 75%, Missing); colon: 69.5035% (minimum 70%, Missing); duodenum: 71.5328% (minimum 75%, Missing); heart muscle: 67.1233% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 70.5036% (minimum 75%, Missing); lymph node: 54.7486% (minimum 70%, Missing); parathyroid gland: 60.4938% (minimum 70%, Missing); rectum: 65.7718% (minimum 70%, Missing); retina: 59.3939% (minimum 75%, Missing); skeletal muscle: 70.5036% (minimum 75%, Missing); skin: 57.6471% (minimum 65%, Missing); small intestine: 70.0000% (minimum 75%, Missing); smooth muscle: 69.5035% (minimum 75%, Missing); spinal cord: 74.8092% (minimum 75%, Missing); spleen: 60.1227% (minimum 65%, Missing); stomach: 67.1233% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 53.5519% (minimum 65%, Missing); tongue: 67.5862% (minimum 70%, Missing)",-0.15,-0.152514,-0.271951,0,80,unavailable,10.7,8.1,9.8,"bone marrow: 10.7 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.5 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 2); skin: 7.2 nTPM (manageable, limit 5); retina: 6.7 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); parathyroid gland: 6.4 nTPM (protected, limit 2); cerebral cortex: 5.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 2); kidney: 4.9 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); heart muscle: 4.8 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198521,ZNF43,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.5328% (minimum 75%, Missing); bone marrow: 47.8049% (minimum 75%, Missing); cerebellum: 72.5926% (minimum 75%, Missing); cerebral cortex: 62.8205% (minimum 75%, Missing); colon: 69.5035% (minimum 70%, Missing); duodenum: 71.5328% (minimum 75%, Missing); heart muscle: 67.1233% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 70.5036% (minimum 75%, Missing); lymph node: 54.7486% (minimum 70%, Missing); parathyroid gland: 60.4938% (minimum 70%, Missing); rectum: 65.7718% (minimum 70%, Missing); retina: 59.3939% (minimum 75%, Missing); skeletal muscle: 70.5036% (minimum 75%, Missing); skin: 57.6471% (minimum 65%, Missing); small intestine: 70.0000% (minimum 75%, Missing); smooth muscle: 69.5035% (minimum 75%, Missing); spinal cord: 74.8092% (minimum 75%, Missing); spleen: 60.1227% (minimum 65%, Missing); stomach: 67.1233% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 53.5519% (minimum 65%, Missing); tongue: 67.5862% (minimum 70%, Missing)",-0.15,-0.152514,-0.271951,0,80,unavailable,10.7,8.1,9.8,"bone marrow: 10.7 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.5 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 3); skin: 7.2 nTPM (manageable, limit 5); retina: 6.7 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); parathyroid gland: 6.4 nTPM (protected, limit 3); cerebral cortex: 5.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 3); kidney: 4.9 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); heart muscle: 4.8 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198521,ZNF43,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.5328% (minimum 75%, Missing); bone marrow: 47.8049% (minimum 75%, Missing); cerebellum: 72.5926% (minimum 75%, Missing); cerebral cortex: 62.8205% (minimum 75%, Missing); colon: 69.5035% (minimum 70%, Missing); duodenum: 71.5328% (minimum 75%, Missing); heart muscle: 67.1233% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 70.5036% (minimum 75%, Missing); lymph node: 54.7486% (minimum 70%, Missing); parathyroid gland: 60.4938% (minimum 70%, Missing); rectum: 65.7718% (minimum 70%, Missing); retina: 59.3939% (minimum 75%, Missing); skeletal muscle: 70.5036% (minimum 75%, Missing); skin: 57.6471% (minimum 65%, Missing); small intestine: 70.0000% (minimum 75%, Missing); smooth muscle: 69.5035% (minimum 75%, Missing); spinal cord: 74.8092% (minimum 75%, Missing); spleen: 60.1227% (minimum 65%, Missing); stomach: 67.1233% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 53.5519% (minimum 65%, Missing); tongue: 67.5862% (minimum 70%, Missing)",-0.15,-0.152514,-0.271951,0,80,unavailable,10.7,8.1,9.8,"bone marrow: 10.7 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.5 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 3); skin: 7.2 nTPM (manageable, limit 5); retina: 6.7 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); parathyroid gland: 6.4 nTPM (protected, limit 3); cerebral cortex: 5.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 3); kidney: 4.9 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); heart muscle: 4.8 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198521,ZNF43,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.5328% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 47.8049% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.5926% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.8205% (minimum 75%, Baseline (adaptation disabled)); colon: 69.5035% (minimum 70%, Baseline (adaptation disabled)); duodenum: 71.5328% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 67.1233% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lung: 70.5036% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.7486% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 60.4938% (minimum 70%, Baseline (adaptation disabled)); rectum: 65.7718% (minimum 70%, Baseline (adaptation disabled)); retina: 59.3939% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 70.5036% (minimum 75%, Baseline (adaptation disabled)); skin: 57.6471% (minimum 65%, Baseline (adaptation disabled)); small intestine: 70.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 69.5035% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.8092% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.1227% (minimum 65%, Baseline (adaptation disabled)); stomach: 67.1233% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.5519% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.5862% (minimum 70%, Baseline (adaptation disabled))",-0.15,-0.152514,-0.271951,0,80,unavailable,10.7,8.1,9.8,"bone marrow: 10.7 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.5 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 3); skin: 7.2 nTPM (manageable, limit 5); retina: 6.7 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); parathyroid gland: 6.4 nTPM (protected, limit 3); cerebral cortex: 5.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 3); kidney: 4.9 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); heart muscle: 4.8 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198521,ZNF43,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 86.4407% (minimum 95%, Enhanced); amygdala: 91.0714% (minimum 99%, Missing); basal ganglia: 85.0000% (minimum 99%, Missing); bone marrow: 41.8033% (minimum 99%, Missing); cerebellum: 83.6066% (minimum 95%, Enhanced); cerebral cortex: 79.6875% (minimum 95%, Enhanced); choroid plexus: 94.4444% (minimum 99%, Missing); colon: 65.3846% (minimum 97%, Missing); duodenum: 73.9130% (minimum 99%, Missing); esophagus: 68.0000% (minimum 97%, Missing); heart muscle: 86.4407% (minimum 95%, Enhanced); hippocampal formation: 89.4737% (minimum 99%, Missing); hypothalamus: 92.7273% (minimum 99%, Missing); kidney: 83.6066% (minimum 99%, Missing); liver: 82.2581% (minimum 95%, Enhanced); lung: 79.6875% (minimum 99%, Missing); lymph node: 48.5714% (minimum 97%, Missing); midbrain: 92.7273% (minimum 99%, Missing); pancreas: 85.0000% (minimum 99%, Missing); parathyroid gland: 78.4615% (minimum 97%, Missing); pituitary gland: 94.4444% (minimum 99%, Missing); rectum: 56.6667% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); salivary gland: 87.9310% (minimum 97%, Missing); skeletal muscle: 89.4737% (minimum 95%, Enhanced); skin: 71.8310% (minimum 95%, Missing); small intestine: 76.1194% (minimum 99%, Missing); smooth muscle: 67.1053% (minimum 95%, Enhanced); spinal cord: 91.0714% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 77.2727% (minimum 97%, Missing); thymus: 39.5349% (minimum 95%, Missing); tongue: 86.4407% (minimum 97%, Missing); urinary bladder: 76.1194% (minimum 97%, Missing)",-0.554651,-0.484286,-0.571967,0,7,partial,7.1,5.4,7.8,"thymus: 7.8 nTPM (manageable, limit 5); bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); esophagus: 2.4 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198554,WDHD1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 41.8033% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); duodenum: 73.9130% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); lymph node: 48.5714% (minimum 70%, Missing); rectum: 56.6667% (minimum 70%, Missing); thymus: 39.5349% (minimum 65%, Missing)",-0.254651,-0.214286,-0.331967,0,7,partial,7.1,5.4,7.8,"thymus: 7.8 nTPM (manageable, limit 5); bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); esophagus: 2.4 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198554,WDHD1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 41.8033% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); duodenum: 73.9130% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); lymph node: 48.5714% (minimum 70%, Missing); rectum: 56.6667% (minimum 70%, Missing); thymus: 39.5349% (minimum 65%, Missing)",-0.254651,-0.214286,-0.331967,0,7,partial,7.1,5.4,7.8,"thymus: 7.8 nTPM (manageable, limit 5); bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198554,WDHD1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 41.8033% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); duodenum: 73.9130% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); lymph node: 48.5714% (minimum 70%, Missing); rectum: 56.6667% (minimum 70%, Missing); thymus: 39.5349% (minimum 65%, Missing)",-0.254651,-0.214286,-0.331967,0,7,partial,7.1,5.4,7.8,"thymus: 7.8 nTPM (manageable, limit 5); bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198554,WDHD1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 41.8033% (minimum 75%, Baseline (adaptation disabled)); colon: 65.3846% (minimum 70%, Baseline (adaptation disabled)); duodenum: 73.9130% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.0000% (minimum 70%, Baseline (adaptation disabled)); lymph node: 48.5714% (minimum 70%, Baseline (adaptation disabled)); rectum: 56.6667% (minimum 70%, Baseline (adaptation disabled)); smooth muscle: 67.1053% (minimum 75%, Baseline (adaptation disabled)); thymus: 39.5349% (minimum 65%, Baseline (adaptation disabled))",-0.254651,-0.214286,-0.331967,0,7,partial,7.1,5.4,7.8,"thymus: 7.8 nTPM (manageable, limit 5); bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); smooth muscle: 2.5 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198554,WDHD1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198573,SPANXC,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198573,SPANXC,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198573,SPANXC,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198573,SPANXC,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198573,SPANXC,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.7959% (minimum 95%, Missing); adrenal gland: 63.3333% (minimum 99%, Missing); amygdala: 61.7329% (minimum 99%, Missing); basal ganglia: 62.8676% (minimum 99%, Missing); bone marrow: 61.0714% (minimum 99%, Missing); cerebellum: 73.7069% (minimum 99%, Missing); cerebral cortex: 56.8106% (minimum 99%, Missing); choroid plexus: 68.4000% (minimum 99%, Missing); colon: 57.5758% (minimum 97%, Missing); duodenum: 65.0190% (minimum 99%, Missing); esophagus: 65.5172% (minimum 97%, Missing); heart muscle: 71.8487% (minimum 99%, Missing); hippocampal formation: 62.4088% (minimum 99%, Missing); hypothalamus: 64.2857% (minimum 99%, Missing); kidney: 57.7703% (minimum 99%, Missing); liver: 54.4586% (minimum 99%, Missing); lung: 67.8571% (minimum 99%, Missing); lymph node: 53.7736% (minimum 97%, Missing); midbrain: 61.5108% (minimum 99%, Missing); pancreas: 62.8676% (minimum 99%, Missing); parathyroid gland: 49.4220% (minimum 97%, Missing); pituitary gland: 74.0260% (minimum 99%, Missing); rectum: 58.9655% (minimum 97%, Missing); retina: 52.7778% (minimum 99%, Missing); salivary gland: 65.7692% (minimum 97%, Missing); skeletal muscle: 52.1341% (minimum 99%, Missing); skin: 67.3228% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 60.2113% (minimum 99%, Missing); spinal cord: 63.3333% (minimum 99%, Missing); spleen: 57.1906% (minimum 95%, Missing); stomach: 56.6225% (minimum 97%, Missing); thymus: 56.0656% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 76.3393% (minimum 97%, Missing); urinary bladder: 60.2113% (minimum 97%, Missing)",-0.45,-0.47578,-0.468659,0,4,partial,15.7,17.5,17.1,"parathyroid gland: 17.5 nTPM (protected, limit 2); thyroid gland: 17.1 nTPM (manageable, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 2); liver: 14.3 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 2); cerebral cortex: 13 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); colon: 12.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 2); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 2); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); salivary gland: 8.9 nTPM (protected, limit 2); skin: 8.3 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198586,TLK1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.3333% (minimum 75%, Missing); amygdala: 61.7329% (minimum 75%, Missing); basal ganglia: 62.8676% (minimum 75%, Missing); bone marrow: 61.0714% (minimum 75%, Missing); cerebellum: 73.7069% (minimum 75%, Missing); cerebral cortex: 56.8106% (minimum 75%, Missing); choroid plexus: 68.4000% (minimum 75%, Missing); colon: 57.5758% (minimum 70%, Missing); duodenum: 65.0190% (minimum 75%, Missing); esophagus: 65.5172% (minimum 70%, Missing); heart muscle: 71.8487% (minimum 75%, Missing); hippocampal formation: 62.4088% (minimum 75%, Missing); hypothalamus: 64.2857% (minimum 75%, Missing); kidney: 57.7703% (minimum 75%, Missing); liver: 54.4586% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); lymph node: 53.7736% (minimum 70%, Missing); midbrain: 61.5108% (minimum 75%, Missing); pancreas: 62.8676% (minimum 75%, Missing); parathyroid gland: 49.4220% (minimum 70%, Missing); pituitary gland: 74.0260% (minimum 75%, Missing); rectum: 58.9655% (minimum 70%, Missing); retina: 52.7778% (minimum 75%, Missing); salivary gland: 65.7692% (minimum 70%, Missing); skeletal muscle: 52.1341% (minimum 75%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 60.2113% (minimum 75%, Missing); spinal cord: 63.3333% (minimum 75%, Missing); spleen: 57.1906% (minimum 65%, Missing); stomach: 56.6225% (minimum 70%, Missing); thymus: 56.0656% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); urinary bladder: 60.2113% (minimum 70%, Missing)",-0.15,-0.20578,-0.228659,0,4,partial,15.7,17.5,17.1,"parathyroid gland: 17.5 nTPM (protected, limit 2); thyroid gland: 17.1 nTPM (manageable, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 2); liver: 14.3 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 2); cerebral cortex: 13 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); colon: 12.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 2); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 2); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); salivary gland: 8.9 nTPM (protected, limit 2); skin: 8.3 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198586,TLK1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.3333% (minimum 75%, Missing); amygdala: 61.7329% (minimum 75%, Missing); basal ganglia: 62.8676% (minimum 75%, Missing); bone marrow: 61.0714% (minimum 75%, Missing); cerebellum: 73.7069% (minimum 75%, Missing); cerebral cortex: 56.8106% (minimum 75%, Missing); choroid plexus: 68.4000% (minimum 75%, Missing); colon: 57.5758% (minimum 70%, Missing); duodenum: 65.0190% (minimum 75%, Missing); esophagus: 65.5172% (minimum 70%, Missing); heart muscle: 71.8487% (minimum 75%, Missing); hippocampal formation: 62.4088% (minimum 75%, Missing); hypothalamus: 64.2857% (minimum 75%, Missing); kidney: 57.7703% (minimum 75%, Missing); liver: 54.4586% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); lymph node: 53.7736% (minimum 70%, Missing); midbrain: 61.5108% (minimum 75%, Missing); pancreas: 62.8676% (minimum 75%, Missing); parathyroid gland: 49.4220% (minimum 70%, Missing); pituitary gland: 74.0260% (minimum 75%, Missing); rectum: 58.9655% (minimum 70%, Missing); retina: 52.7778% (minimum 75%, Missing); salivary gland: 65.7692% (minimum 70%, Missing); skeletal muscle: 52.1341% (minimum 75%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 60.2113% (minimum 75%, Missing); spinal cord: 63.3333% (minimum 75%, Missing); spleen: 57.1906% (minimum 65%, Missing); stomach: 56.6225% (minimum 70%, Missing); thymus: 56.0656% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); urinary bladder: 60.2113% (minimum 70%, Missing)",-0.15,-0.20578,-0.228659,0,4,partial,15.7,17.5,17.1,"parathyroid gland: 17.5 nTPM (protected, limit 3); thyroid gland: 17.1 nTPM (manageable, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 3); liver: 14.3 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 3); cerebral cortex: 13 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); colon: 12.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 3); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 3); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); salivary gland: 8.9 nTPM (protected, limit 3); skin: 8.3 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198586,TLK1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.3333% (minimum 75%, Missing); amygdala: 61.7329% (minimum 75%, Missing); basal ganglia: 62.8676% (minimum 75%, Missing); bone marrow: 61.0714% (minimum 75%, Missing); cerebellum: 73.7069% (minimum 75%, Missing); cerebral cortex: 56.8106% (minimum 75%, Missing); choroid plexus: 68.4000% (minimum 75%, Missing); colon: 57.5758% (minimum 70%, Missing); duodenum: 65.0190% (minimum 75%, Missing); esophagus: 65.5172% (minimum 70%, Missing); heart muscle: 71.8487% (minimum 75%, Missing); hippocampal formation: 62.4088% (minimum 75%, Missing); hypothalamus: 64.2857% (minimum 75%, Missing); kidney: 57.7703% (minimum 75%, Missing); liver: 54.4586% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); lymph node: 53.7736% (minimum 70%, Missing); midbrain: 61.5108% (minimum 75%, Missing); pancreas: 62.8676% (minimum 75%, Missing); parathyroid gland: 49.4220% (minimum 70%, Missing); pituitary gland: 74.0260% (minimum 75%, Missing); rectum: 58.9655% (minimum 70%, Missing); retina: 52.7778% (minimum 75%, Missing); salivary gland: 65.7692% (minimum 70%, Missing); skeletal muscle: 52.1341% (minimum 75%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 60.2113% (minimum 75%, Missing); spinal cord: 63.3333% (minimum 75%, Missing); spleen: 57.1906% (minimum 65%, Missing); stomach: 56.6225% (minimum 70%, Missing); thymus: 56.0656% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); urinary bladder: 60.2113% (minimum 70%, Missing)",-0.15,-0.20578,-0.228659,0,4,partial,15.7,17.5,17.1,"parathyroid gland: 17.5 nTPM (protected, limit 3); thyroid gland: 17.1 nTPM (manageable, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 3); liver: 14.3 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 3); cerebral cortex: 13 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); colon: 12.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 3); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 3); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); salivary gland: 8.9 nTPM (protected, limit 3); skin: 8.3 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198586,TLK1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.3333% (minimum 75%, Baseline (adaptation disabled)); amygdala: 61.7329% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.8676% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.0714% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.7069% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.8106% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.4000% (minimum 75%, Baseline (adaptation disabled)); colon: 57.5758% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.0190% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.5172% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 71.8487% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 62.4088% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.2857% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.7703% (minimum 75%, Baseline (adaptation disabled)); liver: 54.4586% (minimum 75%, Baseline (adaptation disabled)); lung: 67.8571% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.7736% (minimum 70%, Baseline (adaptation disabled)); midbrain: 61.5108% (minimum 75%, Baseline (adaptation disabled)); pancreas: 62.8676% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.4220% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 74.0260% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.9655% (minimum 70%, Baseline (adaptation disabled)); retina: 52.7778% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.7692% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 52.1341% (minimum 75%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.2113% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.3333% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.1906% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.6225% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.0656% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 60.2113% (minimum 70%, Baseline (adaptation disabled))",-0.15,-0.20578,-0.228659,0,4,partial,15.7,17.5,17.1,"parathyroid gland: 17.5 nTPM (protected, limit 3); thyroid gland: 17.1 nTPM (manageable, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 3); liver: 14.3 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 3); cerebral cortex: 13 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); colon: 12.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 3); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 3); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); salivary gland: 8.9 nTPM (protected, limit 3); skin: 8.3 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198586,TLK1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198681,MAGEA1,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198681,MAGEA1,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198681,MAGEA1,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198681,MAGEA1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198681,MAGEA1,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 5.1829% (minimum 99%, Missing); duodenum: 80.9524% (minimum 95%, Enhanced); kidney: 66.2338% (minimum 99%, Missing); retina: 1.4626% (minimum 99%, Missing); small intestine: 78.4615% (minimum 95%, Enhanced)",0.0122642,0.03,-0.975374,0,3,partial,343.6,0.2,0.4,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198691,ABCA4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 5.1829% (minimum 75%, Missing); kidney: 66.2338% (minimum 75%, Missing); retina: 1.4626% (minimum 75%, Missing)",0.312264,0.3,-0.735374,0,3,partial,343.6,0.2,0.4,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198691,ABCA4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 5.1829% (minimum 75%, Missing); kidney: 66.2338% (minimum 75%, Missing); retina: 1.4626% (minimum 75%, Missing)",0.312264,0.3,-0.735374,0,3,partial,343.6,0.2,0.4,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198691,ABCA4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 5.1829% (minimum 75%, Missing); kidney: 66.2338% (minimum 75%, Missing); retina: 1.4626% (minimum 75%, Missing)",0.312264,0.3,-0.735374,0,3,partial,343.6,0.2,0.4,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198691,ABCA4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 5.1829% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.2338% (minimum 75%, Baseline (adaptation disabled)); retina: 1.4626% (minimum 75%, Baseline (adaptation disabled))",0.277273,0.262264,-0.735374,0,3,partial,343.6,0.2,0.4,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198691,ABCA4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198704,GPX6,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198704,GPX6,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198704,GPX6,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198704,GPX6,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198704,GPX6,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.5610% (minimum 99%, Missing); amygdala: 98.5222% (minimum 99%, Missing); basal ganglia: 98.5222% (minimum 99%, Missing); bone marrow: 92.5926% (minimum 99%, Missing); cerebral cortex: 98.5222% (minimum 99%, Missing); hippocampal formation: 98.5222% (minimum 99%, Missing); midbrain: 98.0392% (minimum 99%, Missing); pituitary gland: 95.2381% (minimum 99%, Missing); retina: 93.8967% (minimum 99%, Missing); skin: 93.8967% (minimum 95%, Missing); small intestine: 96.6184% (minimum 99%, Missing); spinal cord: 97.5610% (minimum 99%, Missing)",-0.0110329,0.0152217,-0.0640741,0,80,unavailable,1.6,0.3,1.3,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198723,SAXO5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288967,0.285222,0.175926,0,80,unavailable,1.6,0.3,1.3,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198723,SAXO5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288967,0.285222,0.175926,0,80,unavailable,1.6,0.3,1.3,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198723,SAXO5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288967,0.285222,0.175926,0,80,unavailable,1.6,0.3,1.3,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198723,SAXO5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288967,0.285222,0.175926,0,80,unavailable,1.6,0.3,1.3,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198723,SAXO5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.7483% (minimum 99%, Missing); heart muscle: 91.8499% (minimum 95%, Enhanced); hippocampal formation: 98.4743% (minimum 99%, Missing); midbrain: 98.7483% (minimum 99%, Missing); pituitary gland: 98.4743% (minimum 99%, Missing); spinal cord: 98.4743% (minimum 99%, Missing); thymus: 94.9198% (minimum 95%, Missing)",-0.000802139,0.03,-0.0315006,0,4,partial,6.3,0.9,3.8,"heart muscle: 6.3 nTPM (vital, limit 6); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198754,OXCT2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.299198,0.3,0.234743,0,4,partial,6.3,0.9,3.8,"heart muscle: 6.3 nTPM (vital, limit 6); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198754,OXCT2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.299198,0.3,0.234743,0,4,partial,6.3,0.9,3.8,"heart muscle: 6.3 nTPM (vital, limit 6); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198754,OXCT2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.299198,0.3,0.234743,0,4,partial,6.3,0.9,3.8,"heart muscle: 6.3 nTPM (vital, limit 6); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198754,OXCT2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.299198,0.287483,0.168499,0,4,partial,6.3,0.9,3.8,"heart muscle: 6.3 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198754,OXCT2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0496794,0.0274412,0.00600767,0,2,partial,24.8,10.3,19.5,"lung: 24.8 nTPM (vital, limit 6); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198759,EGFL6,admission_only,True,False,False,False,10.1158/0008-5472.CAN-16-0225,Bai 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349679,0.297441,0.246008,0,2,partial,24.8,10.3,19.5,"lung: 24.8 nTPM (vital, limit 6); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198759,EGFL6,selectivity_revised,True,False,False,False,10.1158/0008-5472.CAN-16-0225,Bai 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349679,0.297441,0.246008,0,2,partial,24.8,10.3,19.5,"lung: 24.8 nTPM (vital, limit 6); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198759,EGFL6,grid_revised,True,False,False,False,10.1158/0008-5472.CAN-16-0225,Bai 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349679,0.297441,0.246008,0,2,partial,24.8,10.3,19.5,"lung: 24.8 nTPM (vital, limit 6); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198759,EGFL6,current_adaptive,True,False,False,False,10.1158/0008-5472.CAN-16-0225,Bai 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319683,0.283754,0.211758,0,2,partial,24.8,10.3,19.5,"lung: 24.8 nTPM (vital, limit 1); adipose tissue: 19.5 nTPM (manageable, limit 5); urinary bladder: 10.3 nTPM (protected, limit 3); esophagus: 4.2 nTPM (protected, limit 3); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198759,EGFL6,current_fixed,True,False,False,False,10.1158/0008-5472.CAN-16-0225,Bai 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198765,SYCP1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198765,SYCP1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198765,SYCP1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198765,SYCP1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347442,0.3,0.25,0,4,partial,0,0,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198765,SYCP1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Missing); adrenal gland: 93.3333% (minimum 99%, Missing); amygdala: 56.0000% (minimum 99%, Missing); basal ganglia: 82.3529% (minimum 99%, Missing); bone marrow: 93.3333% (minimum 99%, Missing); cerebral cortex: 15.9091% (minimum 99%, Missing); colon: 87.5000% (minimum 97%, Missing); duodenum: 93.3333% (minimum 99%, Missing); esophagus: 93.3333% (minimum 97%, Missing); heart muscle: 70.0000% (minimum 99%, Missing); hippocampal formation: 58.3333% (minimum 99%, Missing); hypothalamus: 42.4242% (minimum 99%, Missing); kidney: 93.3333% (minimum 99%, Missing); liver: 87.5000% (minimum 99%, Missing); lung: 93.3333% (minimum 99%, Missing); lymph node: 77.7778% (minimum 97%, Missing); midbrain: 58.3333% (minimum 99%, Missing); pancreas: 93.3333% (minimum 99%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 63.6364% (minimum 99%, Missing); salivary gland: 87.5000% (minimum 97%, Missing); skeletal muscle: 93.3333% (minimum 99%, Missing); skin: 82.3529% (minimum 95%, Missing); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spinal cord: 77.7778% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 93.3333% (minimum 97%, Missing); thymus: 93.3333% (minimum 95%, Missing); thyroid gland: 93.3333% (minimum 95%, Missing); tongue: 93.3333% (minimum 97%, Missing)",-0.283333,-0.192222,-0.830909,0,80,unavailable,7.4,0.4,0.7,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198785,GRIN3A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 56.0000% (minimum 75%, Missing); cerebral cortex: 15.9091% (minimum 75%, Missing); heart muscle: 70.0000% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 42.4242% (minimum 75%, Missing); midbrain: 58.3333% (minimum 75%, Missing); retina: 63.6364% (minimum 75%, Missing)",0.0166667,0.0777778,-0.590909,0,80,unavailable,7.4,0.4,0.7,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198785,GRIN3A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 56.0000% (minimum 75%, Missing); cerebral cortex: 15.9091% (minimum 75%, Missing); heart muscle: 70.0000% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 42.4242% (minimum 75%, Missing); midbrain: 58.3333% (minimum 75%, Missing); retina: 63.6364% (minimum 75%, Missing)",0.0166667,0.0777778,-0.590909,0,80,unavailable,7.4,0.4,0.7,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198785,GRIN3A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 56.0000% (minimum 75%, Missing); cerebral cortex: 15.9091% (minimum 75%, Missing); heart muscle: 70.0000% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 42.4242% (minimum 75%, Missing); midbrain: 58.3333% (minimum 75%, Missing); retina: 63.6364% (minimum 75%, Missing)",0.0166667,0.0777778,-0.590909,0,80,unavailable,7.4,0.4,0.7,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198785,GRIN3A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 56.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 15.9091% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 42.4242% (minimum 75%, Baseline (adaptation disabled)); midbrain: 58.3333% (minimum 75%, Baseline (adaptation disabled)); retina: 63.6364% (minimum 75%, Baseline (adaptation disabled))",0.0166667,0.0777778,-0.590909,0,80,unavailable,7.4,0.4,0.7,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198785,GRIN3A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198798,MAGEB3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198798,MAGEB3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198798,MAGEB3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198798,MAGEB3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198798,MAGEB3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 49.3213% (minimum 95%, Missing); adrenal gland: 63.5569% (minimum 99%, Missing); amygdala: 59.7260% (minimum 99%, Missing); basal ganglia: 54.7739% (minimum 99%, Missing); bone marrow: 42.2481% (minimum 99%, Missing); cerebellum: 43.0830% (minimum 99%, Missing); cerebral cortex: 54.0943% (minimum 99%, Missing); choroid plexus: 64.3068% (minimum 99%, Missing); colon: 55.8974% (minimum 97%, Missing); duodenum: 58.7601% (minimum 99%, Missing); esophagus: 59.2391% (minimum 97%, Missing); heart muscle: 52.9126% (minimum 99%, Missing); hippocampal formation: 56.3307% (minimum 99%, Missing); hypothalamus: 58.1333% (minimum 99%, Missing); kidney: 62.6437% (minimum 99%, Missing); liver: 57.9787% (minimum 99%, Missing); lung: 54.7739% (minimum 99%, Missing); lymph node: 55.6122% (minimum 97%, Missing); midbrain: 64.6884% (minimum 99%, Missing); pancreas: 54.2289% (minimum 99%, Missing); parathyroid gland: 51.2941% (minimum 97%, Missing); pituitary gland: 56.7708% (minimum 99%, Missing); rectum: 55.3299% (minimum 97%, Missing); retina: 53.6946% (minimum 99%, Missing); salivary gland: 57.0681% (minimum 97%, Missing); skeletal muscle: 34.9359% (minimum 99%, Missing); skin: 49.5455% (minimum 95%, Missing); small intestine: 56.0411% (minimum 99%, Missing); smooth muscle: 56.0411% (minimum 99%, Missing); spinal cord: 63.7427% (minimum 99%, Missing); spleen: 56.6234% (minimum 95%, Missing); stomach: 56.1856% (minimum 97%, Missing); thymus: 50.2304% (minimum 95%, Missing); thyroid gland: 53.9604% (minimum 95%, Missing); tongue: 43.7751% (minimum 97%, Missing); urinary bladder: 55.1899% (minimum 97%, Missing)",-0.456787,-0.532249,-0.640641,0,80,unavailable,40.6,28,22.4,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 2); adipose tissue: 22.4 nTPM (manageable, limit 5); skin: 22.2 nTPM (manageable, limit 5); thymus: 21.6 nTPM (manageable, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (manageable, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 2); rectum: 17.6 nTPM (protected, limit 2); lymph node: 17.4 nTPM (protected, limit 2); colon: 17.2 nTPM (protected, limit 2); smooth muscle: 17.1 nTPM (vital, limit 1); small intestine: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 2); hippocampal formation: 16.9 nTPM (vital, limit 1); spleen: 16.7 nTPM (manageable, limit 5); pituitary gland: 16.6 nTPM (vital, limit 1); salivary gland: 16.4 nTPM (protected, limit 2); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 2); amygdala: 14.7 nTPM (vital, limit 1); kidney: 13 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198815,FOXJ3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 49.3213% (minimum 65%, Missing); adrenal gland: 63.5569% (minimum 75%, Missing); amygdala: 59.7260% (minimum 75%, Missing); basal ganglia: 54.7739% (minimum 75%, Missing); bone marrow: 42.2481% (minimum 75%, Missing); cerebellum: 43.0830% (minimum 75%, Missing); cerebral cortex: 54.0943% (minimum 75%, Missing); choroid plexus: 64.3068% (minimum 75%, Missing); colon: 55.8974% (minimum 70%, Missing); duodenum: 58.7601% (minimum 75%, Missing); esophagus: 59.2391% (minimum 70%, Missing); heart muscle: 52.9126% (minimum 75%, Missing); hippocampal formation: 56.3307% (minimum 75%, Missing); hypothalamus: 58.1333% (minimum 75%, Missing); kidney: 62.6437% (minimum 75%, Missing); liver: 57.9787% (minimum 75%, Missing); lung: 54.7739% (minimum 75%, Missing); lymph node: 55.6122% (minimum 70%, Missing); midbrain: 64.6884% (minimum 75%, Missing); pancreas: 54.2289% (minimum 75%, Missing); parathyroid gland: 51.2941% (minimum 70%, Missing); pituitary gland: 56.7708% (minimum 75%, Missing); rectum: 55.3299% (minimum 70%, Missing); retina: 53.6946% (minimum 75%, Missing); salivary gland: 57.0681% (minimum 70%, Missing); skeletal muscle: 34.9359% (minimum 75%, Missing); skin: 49.5455% (minimum 65%, Missing); small intestine: 56.0411% (minimum 75%, Missing); smooth muscle: 56.0411% (minimum 75%, Missing); spinal cord: 63.7427% (minimum 75%, Missing); spleen: 56.6234% (minimum 65%, Missing); stomach: 56.1856% (minimum 70%, Missing); thymus: 50.2304% (minimum 65%, Missing); thyroid gland: 53.9604% (minimum 65%, Missing); tongue: 43.7751% (minimum 70%, Missing); urinary bladder: 55.1899% (minimum 70%, Missing)",-0.156787,-0.262249,-0.400641,0,80,unavailable,40.6,28,22.4,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 2); adipose tissue: 22.4 nTPM (manageable, limit 5); skin: 22.2 nTPM (manageable, limit 5); thymus: 21.6 nTPM (manageable, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (manageable, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 2); rectum: 17.6 nTPM (protected, limit 2); lymph node: 17.4 nTPM (protected, limit 2); colon: 17.2 nTPM (protected, limit 2); smooth muscle: 17.1 nTPM (vital, limit 1); small intestine: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 2); hippocampal formation: 16.9 nTPM (vital, limit 1); spleen: 16.7 nTPM (manageable, limit 5); pituitary gland: 16.6 nTPM (vital, limit 1); salivary gland: 16.4 nTPM (protected, limit 2); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 2); amygdala: 14.7 nTPM (vital, limit 1); kidney: 13 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198815,FOXJ3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 49.3213% (minimum 65%, Missing); adrenal gland: 63.5569% (minimum 75%, Missing); amygdala: 59.7260% (minimum 75%, Missing); basal ganglia: 54.7739% (minimum 75%, Missing); bone marrow: 42.2481% (minimum 75%, Missing); cerebellum: 43.0830% (minimum 75%, Missing); cerebral cortex: 54.0943% (minimum 75%, Missing); choroid plexus: 64.3068% (minimum 75%, Missing); colon: 55.8974% (minimum 70%, Missing); duodenum: 58.7601% (minimum 75%, Missing); esophagus: 59.2391% (minimum 70%, Missing); heart muscle: 52.9126% (minimum 75%, Missing); hippocampal formation: 56.3307% (minimum 75%, Missing); hypothalamus: 58.1333% (minimum 75%, Missing); kidney: 62.6437% (minimum 75%, Missing); liver: 57.9787% (minimum 75%, Missing); lung: 54.7739% (minimum 75%, Missing); lymph node: 55.6122% (minimum 70%, Missing); midbrain: 64.6884% (minimum 75%, Missing); pancreas: 54.2289% (minimum 75%, Missing); parathyroid gland: 51.2941% (minimum 70%, Missing); pituitary gland: 56.7708% (minimum 75%, Missing); rectum: 55.3299% (minimum 70%, Missing); retina: 53.6946% (minimum 75%, Missing); salivary gland: 57.0681% (minimum 70%, Missing); skeletal muscle: 34.9359% (minimum 75%, Missing); skin: 49.5455% (minimum 65%, Missing); small intestine: 56.0411% (minimum 75%, Missing); smooth muscle: 56.0411% (minimum 75%, Missing); spinal cord: 63.7427% (minimum 75%, Missing); spleen: 56.6234% (minimum 65%, Missing); stomach: 56.1856% (minimum 70%, Missing); thymus: 50.2304% (minimum 65%, Missing); thyroid gland: 53.9604% (minimum 65%, Missing); tongue: 43.7751% (minimum 70%, Missing); urinary bladder: 55.1899% (minimum 70%, Missing)",-0.156787,-0.262249,-0.400641,0,80,unavailable,40.6,28,22.4,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 3); adipose tissue: 22.4 nTPM (manageable, limit 5); skin: 22.2 nTPM (manageable, limit 5); thymus: 21.6 nTPM (manageable, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (manageable, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 3); rectum: 17.6 nTPM (protected, limit 3); lymph node: 17.4 nTPM (protected, limit 3); colon: 17.2 nTPM (protected, limit 3); smooth muscle: 17.1 nTPM (vital, limit 1); small intestine: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 3); hippocampal formation: 16.9 nTPM (vital, limit 1); spleen: 16.7 nTPM (manageable, limit 5); pituitary gland: 16.6 nTPM (vital, limit 1); salivary gland: 16.4 nTPM (protected, limit 3); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 3); amygdala: 14.7 nTPM (vital, limit 1); kidney: 13 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198815,FOXJ3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 49.3213% (minimum 65%, Missing); adrenal gland: 63.5569% (minimum 75%, Missing); amygdala: 59.7260% (minimum 75%, Missing); basal ganglia: 54.7739% (minimum 75%, Missing); bone marrow: 42.2481% (minimum 75%, Missing); cerebellum: 43.0830% (minimum 75%, Missing); cerebral cortex: 54.0943% (minimum 75%, Missing); choroid plexus: 64.3068% (minimum 75%, Missing); colon: 55.8974% (minimum 70%, Missing); duodenum: 58.7601% (minimum 75%, Missing); esophagus: 59.2391% (minimum 70%, Missing); heart muscle: 52.9126% (minimum 75%, Missing); hippocampal formation: 56.3307% (minimum 75%, Missing); hypothalamus: 58.1333% (minimum 75%, Missing); kidney: 62.6437% (minimum 75%, Missing); liver: 57.9787% (minimum 75%, Missing); lung: 54.7739% (minimum 75%, Missing); lymph node: 55.6122% (minimum 70%, Missing); midbrain: 64.6884% (minimum 75%, Missing); pancreas: 54.2289% (minimum 75%, Missing); parathyroid gland: 51.2941% (minimum 70%, Missing); pituitary gland: 56.7708% (minimum 75%, Missing); rectum: 55.3299% (minimum 70%, Missing); retina: 53.6946% (minimum 75%, Missing); salivary gland: 57.0681% (minimum 70%, Missing); skeletal muscle: 34.9359% (minimum 75%, Missing); skin: 49.5455% (minimum 65%, Missing); small intestine: 56.0411% (minimum 75%, Missing); smooth muscle: 56.0411% (minimum 75%, Missing); spinal cord: 63.7427% (minimum 75%, Missing); spleen: 56.6234% (minimum 65%, Missing); stomach: 56.1856% (minimum 70%, Missing); thymus: 50.2304% (minimum 65%, Missing); thyroid gland: 53.9604% (minimum 65%, Missing); tongue: 43.7751% (minimum 70%, Missing); urinary bladder: 55.1899% (minimum 70%, Missing)",-0.156787,-0.262249,-0.400641,0,80,unavailable,40.6,28,22.4,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 3); adipose tissue: 22.4 nTPM (manageable, limit 5); skin: 22.2 nTPM (manageable, limit 5); thymus: 21.6 nTPM (manageable, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (manageable, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 3); rectum: 17.6 nTPM (protected, limit 3); lymph node: 17.4 nTPM (protected, limit 3); colon: 17.2 nTPM (protected, limit 3); smooth muscle: 17.1 nTPM (vital, limit 1); small intestine: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 3); hippocampal formation: 16.9 nTPM (vital, limit 1); spleen: 16.7 nTPM (manageable, limit 5); pituitary gland: 16.6 nTPM (vital, limit 1); salivary gland: 16.4 nTPM (protected, limit 3); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 3); amygdala: 14.7 nTPM (vital, limit 1); kidney: 13 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198815,FOXJ3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 49.3213% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.5569% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.7260% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.7739% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 42.2481% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.0830% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 54.0943% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.3068% (minimum 75%, Baseline (adaptation disabled)); colon: 55.8974% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.7601% (minimum 75%, Baseline (adaptation disabled)); esophagus: 59.2391% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.9126% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 56.3307% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.1333% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.6437% (minimum 75%, Baseline (adaptation disabled)); liver: 57.9787% (minimum 75%, Baseline (adaptation disabled)); lung: 54.7739% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.6122% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.6884% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.2289% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.2941% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 56.7708% (minimum 75%, Baseline (adaptation disabled)); rectum: 55.3299% (minimum 70%, Baseline (adaptation disabled)); retina: 53.6946% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 57.0681% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 34.9359% (minimum 75%, Baseline (adaptation disabled)); skin: 49.5455% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.0411% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.0411% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.7427% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.6234% (minimum 65%, Baseline (adaptation disabled)); stomach: 56.1856% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.2304% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 53.9604% (minimum 65%, Baseline (adaptation disabled)); tongue: 43.7751% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 55.1899% (minimum 70%, Baseline (adaptation disabled))",-0.156787,-0.262249,-0.400641,0,80,unavailable,40.6,28,22.4,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 3); adipose tissue: 22.4 nTPM (manageable, limit 5); skin: 22.2 nTPM (manageable, limit 5); thymus: 21.6 nTPM (manageable, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (manageable, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 3); rectum: 17.6 nTPM (protected, limit 3); lymph node: 17.4 nTPM (protected, limit 3); colon: 17.2 nTPM (protected, limit 3); smooth muscle: 17.1 nTPM (vital, limit 1); small intestine: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 3); hippocampal formation: 16.9 nTPM (vital, limit 1); spleen: 16.7 nTPM (manageable, limit 5); pituitary gland: 16.6 nTPM (vital, limit 1); salivary gland: 16.4 nTPM (protected, limit 3); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 3); amygdala: 14.7 nTPM (vital, limit 1); kidney: 13 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198815,FOXJ3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6420% (minimum 90%, Approved); adrenal gland: 60.6789% (minimum 99%, Missing); amygdala: 42.6653% (minimum 99%, Missing); basal ganglia: 50.4113% (minimum 99%, Missing); bone marrow: 97.5000% (minimum 99%, Missing); cerebellum: 52.4450% (minimum 99%, Missing); cerebral cortex: 37.0787% (minimum 99%, Missing); choroid plexus: 69.6429% (minimum 99%, Missing); colon: 45.1341% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 73.4589% (minimum 97%, Missing); heart muscle: 44.7574% (minimum 99%, Missing); hippocampal formation: 43.8650% (minimum 99%, Missing); hypothalamus: 51.5315% (minimum 99%, Missing); kidney: 62.5364% (minimum 99%, Missing); liver: 56.7460% (minimum 99%, Missing); lung: 63.6027% (minimum 99%, Missing); lymph node: 89.2820% (minimum 97%, Missing); midbrain: 49.7680% (minimum 99%, Missing); pancreas: 63.6027% (minimum 99%, Missing); parathyroid gland: 64.1735% (minimum 95%, Approved); pituitary gland: 59.1316% (minimum 99%, Missing); rectum: 82.8986% (minimum 97%, Missing); retina: 88.2716% (minimum 99%, Missing); salivary gland: 63.3210% (minimum 95%, Approved); skeletal muscle: 33.6207% (minimum 98%, Approved); skin: 69.5864% (minimum 95%, Missing); small intestine: 64.8526% (minimum 99%, Missing); smooth muscle: 70.4433% (minimum 98%, Approved); spinal cord: 56.9343% (minimum 99%, Missing); spleen: 68.9711% (minimum 95%, Missing); stomach: 56.5590% (minimum 97%, Missing); thymus: 86.2312% (minimum 95%, Missing); thyroid gland: 59.6247% (minimum 95%, Missing); tongue: 37.8140% (minimum 97%, Missing); urinary bladder: 50.0876% (minimum 97%, Missing)",-0.353753,-0.59186,-0.643793,0,3,partial,169.4,141.1,68.4,"skeletal muscle: 169.4 nTPM (vital, limit 2); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 2); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 2); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 2); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (manageable, limit 10); stomach: 65.9 nTPM (protected, limit 2); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (manageable, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); salivary gland: 49.7 nTPM (protected, limit 4); lung: 49.1 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 4); small intestine: 46.5 nTPM (vital, limit 1); spleen: 38.6 nTPM (manageable, limit 5); skin: 37.5 nTPM (manageable, limit 5); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 2); esophagus: 31 nTPM (protected, limit 2); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 2); thymus: 13.7 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198816,ZNF358,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6420% (minimum 60%, Approved); adrenal gland: 60.6789% (minimum 75%, Missing); amygdala: 42.6653% (minimum 75%, Missing); basal ganglia: 50.4113% (minimum 75%, Missing); cerebellum: 52.4450% (minimum 75%, Missing); cerebral cortex: 37.0787% (minimum 75%, Missing); choroid plexus: 69.6429% (minimum 75%, Missing); colon: 45.1341% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); heart muscle: 44.7574% (minimum 75%, Missing); hippocampal formation: 43.8650% (minimum 75%, Missing); hypothalamus: 51.5315% (minimum 75%, Missing); kidney: 62.5364% (minimum 75%, Missing); liver: 56.7460% (minimum 75%, Missing); lung: 63.6027% (minimum 75%, Missing); midbrain: 49.7680% (minimum 75%, Missing); pancreas: 63.6027% (minimum 75%, Missing); parathyroid gland: 64.1735% (minimum 65%, Approved); pituitary gland: 59.1316% (minimum 75%, Missing); salivary gland: 63.3210% (minimum 65%, Approved); skeletal muscle: 33.6207% (minimum 70%, Approved); small intestine: 64.8526% (minimum 75%, Missing); spinal cord: 56.9343% (minimum 75%, Missing); stomach: 56.5590% (minimum 70%, Missing); thyroid gland: 59.6247% (minimum 65%, Missing); tongue: 37.8140% (minimum 70%, Missing); urinary bladder: 50.0876% (minimum 70%, Missing)",-0.0537526,-0.32186,-0.379213,0,3,partial,169.4,141.1,68.4,"skeletal muscle: 169.4 nTPM (vital, limit 2); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 2); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 2); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 2); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (manageable, limit 10); stomach: 65.9 nTPM (protected, limit 2); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (manageable, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); salivary gland: 49.7 nTPM (protected, limit 4); lung: 49.1 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 4); small intestine: 46.5 nTPM (vital, limit 1); spleen: 38.6 nTPM (manageable, limit 5); skin: 37.5 nTPM (manageable, limit 5); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 2); esophagus: 31 nTPM (protected, limit 2); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 2); thymus: 13.7 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198816,ZNF358,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6420% (minimum 60%, Approved); adrenal gland: 60.6789% (minimum 75%, Missing); amygdala: 42.6653% (minimum 75%, Missing); basal ganglia: 50.4113% (minimum 75%, Missing); cerebellum: 52.4450% (minimum 75%, Missing); cerebral cortex: 37.0787% (minimum 75%, Missing); choroid plexus: 69.6429% (minimum 75%, Missing); colon: 45.1341% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); heart muscle: 44.7574% (minimum 75%, Missing); hippocampal formation: 43.8650% (minimum 75%, Missing); hypothalamus: 51.5315% (minimum 75%, Missing); kidney: 62.5364% (minimum 75%, Missing); liver: 56.7460% (minimum 75%, Missing); lung: 63.6027% (minimum 75%, Missing); midbrain: 49.7680% (minimum 75%, Missing); pancreas: 63.6027% (minimum 75%, Missing); parathyroid gland: 64.1735% (minimum 65%, Approved); pituitary gland: 59.1316% (minimum 75%, Missing); salivary gland: 63.3210% (minimum 65%, Approved); skeletal muscle: 33.6207% (minimum 70%, Approved); small intestine: 64.8526% (minimum 75%, Missing); spinal cord: 56.9343% (minimum 75%, Missing); stomach: 56.5590% (minimum 70%, Missing); thyroid gland: 59.6247% (minimum 65%, Missing); tongue: 37.8140% (minimum 70%, Missing); urinary bladder: 50.0876% (minimum 70%, Missing)",-0.0537526,-0.32186,-0.379213,0,3,partial,169.4,141.1,68.4,"skeletal muscle: 169.4 nTPM (vital, limit 2); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 3); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 3); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 3); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (manageable, limit 10); stomach: 65.9 nTPM (protected, limit 3); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (manageable, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); salivary gland: 49.7 nTPM (protected, limit 4); lung: 49.1 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 4); small intestine: 46.5 nTPM (vital, limit 1); spleen: 38.6 nTPM (manageable, limit 5); skin: 37.5 nTPM (manageable, limit 5); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 2); esophagus: 31 nTPM (protected, limit 3); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 3); thymus: 13.7 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198816,ZNF358,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6420% (minimum 60%, Approved); adrenal gland: 60.6789% (minimum 75%, Missing); amygdala: 42.6653% (minimum 75%, Missing); basal ganglia: 50.4113% (minimum 75%, Missing); cerebellum: 52.4450% (minimum 75%, Missing); cerebral cortex: 37.0787% (minimum 75%, Missing); choroid plexus: 69.6429% (minimum 75%, Missing); colon: 45.1341% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); heart muscle: 44.7574% (minimum 75%, Missing); hippocampal formation: 43.8650% (minimum 75%, Missing); hypothalamus: 51.5315% (minimum 75%, Missing); kidney: 62.5364% (minimum 75%, Missing); liver: 56.7460% (minimum 75%, Missing); lung: 63.6027% (minimum 75%, Missing); midbrain: 49.7680% (minimum 75%, Missing); pancreas: 63.6027% (minimum 75%, Missing); parathyroid gland: 64.1735% (minimum 65%, Approved); pituitary gland: 59.1316% (minimum 75%, Missing); salivary gland: 63.3210% (minimum 65%, Approved); skeletal muscle: 33.6207% (minimum 70%, Approved); small intestine: 64.8526% (minimum 75%, Missing); spinal cord: 56.9343% (minimum 75%, Missing); stomach: 56.5590% (minimum 70%, Missing); thyroid gland: 59.6247% (minimum 65%, Missing); tongue: 37.8140% (minimum 70%, Missing); urinary bladder: 50.0876% (minimum 70%, Missing)",-0.0537526,-0.32186,-0.379213,0,3,partial,169.4,141.1,68.4,"skeletal muscle: 169.4 nTPM (vital, limit 2); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 3); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 3); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 3); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (manageable, limit 10); stomach: 65.9 nTPM (protected, limit 3); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (manageable, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); salivary gland: 49.7 nTPM (protected, limit 4); lung: 49.1 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 4); small intestine: 46.5 nTPM (vital, limit 1); spleen: 38.6 nTPM (manageable, limit 5); skin: 37.5 nTPM (manageable, limit 5); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 2); esophagus: 31 nTPM (protected, limit 3); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 3); thymus: 13.7 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198816,ZNF358,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6420% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.6789% (minimum 75%, Baseline (adaptation disabled)); amygdala: 42.6653% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 50.4113% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 52.4450% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 37.0787% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 69.6429% (minimum 75%, Baseline (adaptation disabled)); colon: 45.1341% (minimum 70%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 44.7574% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 43.8650% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 51.5315% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.5364% (minimum 75%, Baseline (adaptation disabled)); liver: 56.7460% (minimum 75%, Baseline (adaptation disabled)); lung: 63.6027% (minimum 75%, Baseline (adaptation disabled)); midbrain: 49.7680% (minimum 75%, Baseline (adaptation disabled)); pancreas: 63.6027% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.1735% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 59.1316% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.3210% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 33.6207% (minimum 75%, Baseline (adaptation disabled)); small intestine: 64.8526% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.4433% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.9343% (minimum 75%, Baseline (adaptation disabled)); stomach: 56.5590% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 59.6247% (minimum 65%, Baseline (adaptation disabled)); tongue: 37.8140% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 50.0876% (minimum 70%, Baseline (adaptation disabled))",-0.0935798,-0.32186,-0.413793,0,3,partial,169.4,141.1,68.4,"skeletal muscle: 169.4 nTPM (vital, limit 1); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 3); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 3); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 3); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (manageable, limit 5); stomach: 65.9 nTPM (protected, limit 3); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (manageable, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); salivary gland: 49.7 nTPM (protected, limit 3); lung: 49.1 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 3); small intestine: 46.5 nTPM (vital, limit 1); spleen: 38.6 nTPM (manageable, limit 5); skin: 37.5 nTPM (manageable, limit 5); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 1); esophagus: 31 nTPM (protected, limit 3); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 3); thymus: 13.7 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198816,ZNF358,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 84.0426% (minimum 95%, Missing); adrenal gland: 89.7727% (minimum 99%, Missing); amygdala: 85.8696% (minimum 99%, Missing); basal ganglia: 88.7640% (minimum 99%, Missing); bone marrow: 25.1592% (minimum 99%, Missing); cerebellum: 96.3415% (minimum 99%, Missing); cerebral cortex: 90.8046% (minimum 99%, Missing); choroid plexus: 96.3415% (minimum 99%, Missing); colon: 52.3179% (minimum 97%, Missing); duodenum: 58.0882% (minimum 99%, Missing); esophagus: 61.2403% (minimum 97%, Missing); heart muscle: 91.8605% (minimum 99%, Missing); hippocampal formation: 84.9462% (minimum 99%, Missing); hypothalamus: 85.8696% (minimum 99%, Missing); kidney: 92.9412% (minimum 95%, Enhanced); liver: 86.8132% (minimum 95%, Enhanced); lung: 83.1579% (minimum 99%, Missing); lymph node: 37.9808% (minimum 97%, Missing); midbrain: 73.1481% (minimum 99%, Missing); pancreas: 77.4510% (minimum 99%, Missing); pituitary gland: 92.9412% (minimum 99%, Missing); rectum: 48.4663% (minimum 97%, Missing); retina: 95.1807% (minimum 99%, Missing); salivary gland: 86.8132% (minimum 97%, Missing); skeletal muscle: 90.8046% (minimum 99%, Missing); skin: 65.8333% (minimum 95%, Missing); small intestine: 52.6667% (minimum 99%, Missing); smooth muscle: 63.2000% (minimum 99%, Missing); spinal cord: 55.2448% (minimum 99%, Missing); stomach: 69.9115% (minimum 97%, Missing); thymus: 23.7952% (minimum 95%, Missing); thyroid gland: 87.7778% (minimum 95%, Missing); tongue: 95.1807% (minimum 97%, Missing); urinary bladder: 75.9615% (minimum 97%, Missing)",-0.712048,-0.590192,-0.738408,0,8,partial,23.5,12.9,25.3,"thymus: 25.3 nTPM (manageable, limit 5); bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 2); rectum: 8.4 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); smooth muscle: 4.6 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); midbrain: 2.9 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198826,ARHGAP11A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.1592% (minimum 75%, Missing); colon: 52.3179% (minimum 70%, Missing); duodenum: 58.0882% (minimum 75%, Missing); esophagus: 61.2403% (minimum 70%, Missing); lymph node: 37.9808% (minimum 70%, Missing); midbrain: 73.1481% (minimum 75%, Missing); rectum: 48.4663% (minimum 70%, Missing); small intestine: 52.6667% (minimum 75%, Missing); smooth muscle: 63.2000% (minimum 75%, Missing); spinal cord: 55.2448% (minimum 75%, Missing); stomach: 69.9115% (minimum 70%, Missing); thymus: 23.7952% (minimum 65%, Missing)",-0.412048,-0.320192,-0.498408,0,8,partial,23.5,12.9,25.3,"thymus: 25.3 nTPM (manageable, limit 5); bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 2); rectum: 8.4 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); smooth muscle: 4.6 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); midbrain: 2.9 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198826,ARHGAP11A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.1592% (minimum 75%, Missing); colon: 52.3179% (minimum 70%, Missing); duodenum: 58.0882% (minimum 75%, Missing); esophagus: 61.2403% (minimum 70%, Missing); lymph node: 37.9808% (minimum 70%, Missing); midbrain: 73.1481% (minimum 75%, Missing); rectum: 48.4663% (minimum 70%, Missing); small intestine: 52.6667% (minimum 75%, Missing); smooth muscle: 63.2000% (minimum 75%, Missing); spinal cord: 55.2448% (minimum 75%, Missing); stomach: 69.9115% (minimum 70%, Missing); thymus: 23.7952% (minimum 65%, Missing)",-0.412048,-0.320192,-0.498408,0,8,partial,23.5,12.9,25.3,"thymus: 25.3 nTPM (manageable, limit 5); bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 3); rectum: 8.4 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); smooth muscle: 4.6 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); midbrain: 2.9 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198826,ARHGAP11A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.1592% (minimum 75%, Missing); colon: 52.3179% (minimum 70%, Missing); duodenum: 58.0882% (minimum 75%, Missing); esophagus: 61.2403% (minimum 70%, Missing); lymph node: 37.9808% (minimum 70%, Missing); midbrain: 73.1481% (minimum 75%, Missing); rectum: 48.4663% (minimum 70%, Missing); small intestine: 52.6667% (minimum 75%, Missing); smooth muscle: 63.2000% (minimum 75%, Missing); spinal cord: 55.2448% (minimum 75%, Missing); stomach: 69.9115% (minimum 70%, Missing); thymus: 23.7952% (minimum 65%, Missing)",-0.412048,-0.320192,-0.498408,0,8,partial,23.5,12.9,25.3,"thymus: 25.3 nTPM (manageable, limit 5); bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 3); rectum: 8.4 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); smooth muscle: 4.6 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); midbrain: 2.9 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198826,ARHGAP11A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.1592% (minimum 75%, Baseline (adaptation disabled)); colon: 52.3179% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.0882% (minimum 75%, Baseline (adaptation disabled)); esophagus: 61.2403% (minimum 70%, Baseline (adaptation disabled)); lymph node: 37.9808% (minimum 70%, Baseline (adaptation disabled)); midbrain: 73.1481% (minimum 75%, Baseline (adaptation disabled)); rectum: 48.4663% (minimum 70%, Baseline (adaptation disabled)); small intestine: 52.6667% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.2000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 55.2448% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.9115% (minimum 70%, Baseline (adaptation disabled)); thymus: 23.7952% (minimum 65%, Baseline (adaptation disabled))",-0.412048,-0.320192,-0.498408,0,8,partial,23.5,12.9,25.3,"thymus: 25.3 nTPM (manageable, limit 5); bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 3); rectum: 8.4 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); smooth muscle: 4.6 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); midbrain: 2.9 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198826,ARHGAP11A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.2876% (minimum 95%, Missing); adrenal gland: 59.2593% (minimum 99%, Missing); amygdala: 60.6061% (minimum 99%, Missing); basal ganglia: 58.3942% (minimum 99%, Missing); bone marrow: 84.2105% (minimum 99%, Missing); cerebellum: 86.9565% (minimum 99%, Missing); cerebral cortex: 72.7273% (minimum 99%, Missing); choroid plexus: 74.7664% (minimum 99%, Missing); colon: 61.0687% (minimum 97%, Missing); duodenum: 67.7966% (minimum 99%, Missing); esophagus: 78.4314% (minimum 97%, Missing); heart muscle: 51.6129% (minimum 99%, Missing); hippocampal formation: 57.1429% (minimum 99%, Missing); hypothalamus: 53.3333% (minimum 99%, Missing); kidney: 48.7805% (minimum 99%, Missing); liver: 4.3980% (minimum 99%, Missing); lung: 57.5540% (minimum 99%, Missing); lymph node: 52.6316% (minimum 97%, Missing); midbrain: 41.2371% (minimum 99%, Missing); pancreas: 67.2269% (minimum 99%, Missing); pituitary gland: 51.6129% (minimum 99%, Missing); rectum: 96.3855% (minimum 97%, Missing); retina: 78.4314% (minimum 99%, Missing); salivary gland: 75.4717% (minimum 97%, Missing); skeletal muscle: 82.4742% (minimum 99%, Missing); skin: 71.4286% (minimum 95%, Missing); small intestine: 38.0952% (minimum 99%, Missing); smooth muscle: 95.2381% (minimum 99%, Missing); spinal cord: 29.9625% (minimum 99%, Missing); spleen: 35.3982% (minimum 95%, Missing); stomach: 65.0407% (minimum 97%, Missing); thymus: 67.2269% (minimum 95%, Missing); thyroid gland: 71.4286% (minimum 95%, Missing); tongue: 93.0233% (minimum 97%, Missing); urinary bladder: 75.4717% (minimum 97%, Missing)",-0.596018,-0.443684,-0.94602,0,4,partial,173.9,7.2,14.6,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); spleen: 14.6 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 2); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); stomach: 4.3 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198865,CCDC152,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.2876% (minimum 65%, Missing); adrenal gland: 59.2593% (minimum 75%, Missing); amygdala: 60.6061% (minimum 75%, Missing); basal ganglia: 58.3942% (minimum 75%, Missing); cerebral cortex: 72.7273% (minimum 75%, Missing); choroid plexus: 74.7664% (minimum 75%, Missing); colon: 61.0687% (minimum 70%, Missing); duodenum: 67.7966% (minimum 75%, Missing); heart muscle: 51.6129% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 53.3333% (minimum 75%, Missing); kidney: 48.7805% (minimum 75%, Missing); liver: 4.3980% (minimum 75%, Missing); lung: 57.5540% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); midbrain: 41.2371% (minimum 75%, Missing); pancreas: 67.2269% (minimum 75%, Missing); pituitary gland: 51.6129% (minimum 75%, Missing); small intestine: 38.0952% (minimum 75%, Missing); spinal cord: 29.9625% (minimum 75%, Missing); spleen: 35.3982% (minimum 65%, Missing); stomach: 65.0407% (minimum 70%, Missing)",-0.296018,-0.173684,-0.70602,0,4,partial,173.9,7.2,14.6,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); spleen: 14.6 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 2); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); stomach: 4.3 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198865,CCDC152,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.2876% (minimum 65%, Missing); adrenal gland: 59.2593% (minimum 75%, Missing); amygdala: 60.6061% (minimum 75%, Missing); basal ganglia: 58.3942% (minimum 75%, Missing); cerebral cortex: 72.7273% (minimum 75%, Missing); choroid plexus: 74.7664% (minimum 75%, Missing); colon: 61.0687% (minimum 70%, Missing); duodenum: 67.7966% (minimum 75%, Missing); heart muscle: 51.6129% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 53.3333% (minimum 75%, Missing); kidney: 48.7805% (minimum 75%, Missing); liver: 4.3980% (minimum 75%, Missing); lung: 57.5540% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); midbrain: 41.2371% (minimum 75%, Missing); pancreas: 67.2269% (minimum 75%, Missing); pituitary gland: 51.6129% (minimum 75%, Missing); small intestine: 38.0952% (minimum 75%, Missing); spinal cord: 29.9625% (minimum 75%, Missing); spleen: 35.3982% (minimum 65%, Missing); stomach: 65.0407% (minimum 70%, Missing)",-0.296018,-0.173684,-0.70602,0,4,partial,173.9,7.2,14.6,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); spleen: 14.6 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 3); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); stomach: 4.3 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198865,CCDC152,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.2876% (minimum 65%, Missing); adrenal gland: 59.2593% (minimum 75%, Missing); amygdala: 60.6061% (minimum 75%, Missing); basal ganglia: 58.3942% (minimum 75%, Missing); cerebral cortex: 72.7273% (minimum 75%, Missing); choroid plexus: 74.7664% (minimum 75%, Missing); colon: 61.0687% (minimum 70%, Missing); duodenum: 67.7966% (minimum 75%, Missing); heart muscle: 51.6129% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 53.3333% (minimum 75%, Missing); kidney: 48.7805% (minimum 75%, Missing); liver: 4.3980% (minimum 75%, Missing); lung: 57.5540% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); midbrain: 41.2371% (minimum 75%, Missing); pancreas: 67.2269% (minimum 75%, Missing); pituitary gland: 51.6129% (minimum 75%, Missing); small intestine: 38.0952% (minimum 75%, Missing); spinal cord: 29.9625% (minimum 75%, Missing); spleen: 35.3982% (minimum 65%, Missing); stomach: 65.0407% (minimum 70%, Missing)",-0.296018,-0.173684,-0.70602,0,4,partial,173.9,7.2,14.6,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); spleen: 14.6 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 3); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); stomach: 4.3 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198865,CCDC152,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.2876% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 59.2593% (minimum 75%, Baseline (adaptation disabled)); amygdala: 60.6061% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.3942% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.7273% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 74.7664% (minimum 75%, Baseline (adaptation disabled)); colon: 61.0687% (minimum 70%, Baseline (adaptation disabled)); duodenum: 67.7966% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 51.6129% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.1429% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.3333% (minimum 75%, Baseline (adaptation disabled)); kidney: 48.7805% (minimum 75%, Baseline (adaptation disabled)); liver: 4.3980% (minimum 75%, Baseline (adaptation disabled)); lung: 57.5540% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.6316% (minimum 70%, Baseline (adaptation disabled)); midbrain: 41.2371% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.2269% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 51.6129% (minimum 75%, Baseline (adaptation disabled)); small intestine: 38.0952% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 29.9625% (minimum 75%, Baseline (adaptation disabled)); spleen: 35.3982% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.0407% (minimum 70%, Baseline (adaptation disabled))",-0.296018,-0.173684,-0.70602,0,4,partial,173.9,7.2,14.6,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); spleen: 14.6 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 3); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); stomach: 4.3 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198865,CCDC152,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.9798% (minimum 99%, Missing); amygdala: 97.0000% (minimum 99%, Missing); basal ganglia: 96.0396% (minimum 99%, Missing); bone marrow: 98.9796% (minimum 99%, Missing); cerebellum: 94.1748% (minimum 99%, Missing); cerebral cortex: 94.1748% (minimum 99%, Missing); duodenum: 98.9796% (minimum 99%, Missing); heart muscle: 98.9796% (minimum 99%, Missing); hippocampal formation: 96.0396% (minimum 99%, Missing); hypothalamus: 97.0000% (minimum 99%, Missing); kidney: 97.9798% (minimum 99%, Missing); liver: 97.0000% (minimum 99%, Missing); lung: 98.9796% (minimum 99%, Missing); midbrain: 96.0396% (minimum 99%, Missing); pancreas: 98.9796% (minimum 99%, Missing); pituitary gland: 97.9798% (minimum 99%, Missing); retina: 98.9796% (minimum 99%, Missing); skeletal muscle: 97.9798% (minimum 99%, Missing); small intestine: 98.9796% (minimum 99%, Missing); spinal cord: 95.0980% (minimum 99%, Missing)",0.029798,0.00979798,-0.0482524,0,80,unavailable,0.6,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198870,STKLD1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.329798,0.279798,0.191748,0,80,unavailable,0.6,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198870,STKLD1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.329798,0.279798,0.191748,0,80,unavailable,0.6,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198870,STKLD1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.329798,0.279798,0.191748,0,80,unavailable,0.6,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198870,STKLD1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.329798,0.279798,0.191748,0,80,unavailable,0.6,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198870,STKLD1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 54.1401% (minimum 99%, Missing); basal ganglia: 33.7302% (minimum 99%, Missing); cerebral cortex: 48.2955% (minimum 99%, Missing); choroid plexus: 97.7011% (minimum 99%, Missing); hippocampal formation: 65.3846% (minimum 99%, Missing); hypothalamus: 28.1457% (minimum 99%, Missing); midbrain: 91.3978% (minimum 99%, Missing); pituitary gland: 90.4255% (minimum 99%, Missing); retina: 98.8372% (minimum 99%, Missing); spinal cord: 93.4066% (minimum 99%, Missing)",0.05,0.0183721,-0.708543,0,1,partial,21.7,0.1,0.5,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198883,PNMA5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 54.1401% (minimum 75%, Missing); basal ganglia: 33.7302% (minimum 75%, Missing); cerebral cortex: 48.2955% (minimum 75%, Missing); hippocampal formation: 65.3846% (minimum 75%, Missing); hypothalamus: 28.1457% (minimum 75%, Missing)",0.35,0.288372,-0.468543,0,1,partial,21.7,0.1,0.5,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198883,PNMA5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 54.1401% (minimum 75%, Missing); basal ganglia: 33.7302% (minimum 75%, Missing); cerebral cortex: 48.2955% (minimum 75%, Missing); hippocampal formation: 65.3846% (minimum 75%, Missing); hypothalamus: 28.1457% (minimum 75%, Missing)",0.35,0.288372,-0.468543,0,1,partial,21.7,0.1,0.5,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198883,PNMA5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 54.1401% (minimum 75%, Missing); basal ganglia: 33.7302% (minimum 75%, Missing); cerebral cortex: 48.2955% (minimum 75%, Missing); hippocampal formation: 65.3846% (minimum 75%, Missing); hypothalamus: 28.1457% (minimum 75%, Missing)",0.35,0.288372,-0.468543,0,1,partial,21.7,0.1,0.5,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198883,PNMA5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 54.1401% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 33.7302% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.2955% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.3846% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 28.1457% (minimum 75%, Baseline (adaptation disabled))",0.294444,0.288372,-0.468543,0,1,partial,21.7,0.1,0.5,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198883,PNMA5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.1089% (minimum 95%, Missing); adrenal gland: 98.5401% (minimum 99%, Missing); amygdala: 98.1818% (minimum 99%, Missing); bone marrow: 96.0854% (minimum 99%, Missing); cerebellum: 89.4040% (minimum 99%, Missing); cerebral cortex: 98.1818% (minimum 99%, Missing); choroid plexus: 98.9011% (minimum 99%, Missing); colon: 96.7742% (minimum 97%, Missing); duodenum: 95.7447% (minimum 99%, Missing); esophagus: 94.7368% (minimum 97%, Missing); heart muscle: 95.7447% (minimum 99%, Missing); hippocampal formation: 98.5401% (minimum 99%, Missing); hypothalamus: 98.1818% (minimum 99%, Missing); kidney: 98.1818% (minimum 99%, Missing); liver: 98.1818% (minimum 99%, Missing); lung: 95.0704% (minimum 99%, Missing); lymph node: 87.6623% (minimum 97%, Missing); midbrain: 98.5401% (minimum 99%, Missing); pancreas: 95.4064% (minimum 99%, Missing); pituitary gland: 98.5401% (minimum 99%, Missing); retina: 96.7742% (minimum 99%, Missing); salivary gland: 78.7172% (minimum 97%, Missing); skeletal muscle: 94.7368% (minimum 99%, Missing); small intestine: 94.4056% (minimum 99%, Missing); smooth muscle: 96.7742% (minimum 99%, Missing); spinal cord: 97.1223% (minimum 99%, Missing); spleen: 91.5254% (minimum 95%, Missing); stomach: 96.0854% (minimum 97%, Missing); thymus: 84.3750% (minimum 95%, Missing); tongue: 93.4256% (minimum 97%, Missing); urinary bladder: 95.0704% (minimum 97%, Missing)",-0.10625,-0.182828,-0.0959603,0,80,unavailable,3.2,7.3,5,"salivary gland: 7.3 nTPM (protected, limit 2); lymph node: 3.8 nTPM (protected, limit 2); cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198885,ITPRIPL1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19375,0.087172,0.14404,0,80,unavailable,3.2,7.3,5,"salivary gland: 7.3 nTPM (protected, limit 2); lymph node: 3.8 nTPM (protected, limit 2); cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198885,ITPRIPL1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19375,0.087172,0.14404,0,80,unavailable,3.2,7.3,5,"salivary gland: 7.3 nTPM (protected, limit 3); lymph node: 3.8 nTPM (protected, limit 3); cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198885,ITPRIPL1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19375,0.087172,0.14404,0,80,unavailable,3.2,7.3,5,"salivary gland: 7.3 nTPM (protected, limit 3); lymph node: 3.8 nTPM (protected, limit 3); cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198885,ITPRIPL1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19375,0.087172,0.14404,0,80,unavailable,3.2,7.3,5,"salivary gland: 7.3 nTPM (protected, limit 3); lymph node: 3.8 nTPM (protected, limit 3); cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198885,ITPRIPL1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 98.3607% (minimum 99%, Missing); hypothalamus: 98.3607% (minimum 99%, Missing); kidney: 80.0000% (minimum 99%, Missing); pituitary gland: 96.7742% (minimum 99%, Missing); spleen: 85.7143% (minimum 90%, Approved); stomach: 88.2353% (minimum 97%, Missing); urinary bladder: 96.7742% (minimum 97%, Missing)",-0.0428571,-0.0876471,-0.19,0,5,partial,1.5,0.8,1,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198889,DCAF12L1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.257143,0.182353,0.05,0,5,partial,1.5,0.8,1,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198889,DCAF12L1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.257143,0.182353,0.05,0,5,partial,1.5,0.8,1,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198889,DCAF12L1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.257143,0.182353,0.05,0,5,partial,1.5,0.8,1,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198889,DCAF12L1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.207143,0.182353,0.05,0,5,partial,1.5,0.8,1,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198889,DCAF12L1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.0466% (minimum 90%, Approved); adrenal gland: 78.1395% (minimum 99%, Missing); amygdala: 74.6667% (minimum 99%, Missing); basal ganglia: 67.8788% (minimum 99%, Missing); bone marrow: 89.8396% (minimum 99%, Missing); cerebellum: 70.2929% (minimum 99%, Missing); cerebral cortex: 59.7865% (minimum 99%, Missing); choroid plexus: 60.7595% (minimum 99%, Missing); colon: 87.0466% (minimum 97%, Missing); duodenum: 91.8033% (minimum 99%, Missing); esophagus: 90.0804% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); hippocampal formation: 72.4138% (minimum 99%, Missing); hypothalamus: 65.3696% (minimum 99%, Missing); kidney: 76.1905% (minimum 99%, Missing); liver: 89.1247% (minimum 98%, Approved); lung: 84.2105% (minimum 99%, Missing); lymph node: 77.2414% (minimum 97%, Missing); midbrain: 76.8879% (minimum 99%, Missing); pancreas: 86.5979% (minimum 99%, Missing); parathyroid gland: 81.7518% (minimum 95%, Approved); pituitary gland: 58.4348% (minimum 99%, Missing); rectum: 88.1890% (minimum 97%, Missing); retina: 53.7600% (minimum 99%, Missing); salivary gland: 90.8108% (minimum 97%, Missing); skeletal muscle: 73.8462% (minimum 99%, Missing); skin: 90.5660% (minimum 95%, Missing); small intestine: 89.8396% (minimum 99%, Missing); smooth muscle: 87.0466% (minimum 99%, Missing); spinal cord: 80.3828% (minimum 99%, Missing); spleen: 80.5755% (minimum 90%, Approved); stomach: 84.0000% (minimum 97%, Missing); thymus: 80.1909% (minimum 95%, Missing); thyroid gland: 73.0435% (minimum 95%, Missing); tongue: 68.2927% (minimum 97%, Missing); urinary bladder: 87.0466% (minimum 95%, Approved)",-0.219565,-0.287073,-0.4524,0,4,partial,28.9,15.6,12.4,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 2); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (manageable, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 2); adrenal gland: 9.4 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 4); stomach: 6.4 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 4); rectum: 4.5 nTPM (protected, limit 2); liver: 4.1 nTPM (vital, limit 2); small intestine: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198919,DZIP3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 74.6667% (minimum 75%, Missing); basal ganglia: 67.8788% (minimum 75%, Missing); cerebellum: 70.2929% (minimum 75%, Missing); cerebral cortex: 59.7865% (minimum 75%, Missing); choroid plexus: 60.7595% (minimum 75%, Missing); hippocampal formation: 72.4138% (minimum 75%, Missing); hypothalamus: 65.3696% (minimum 75%, Missing); pituitary gland: 58.4348% (minimum 75%, Missing); retina: 53.7600% (minimum 75%, Missing); skeletal muscle: 73.8462% (minimum 75%, Missing); tongue: 68.2927% (minimum 70%, Missing)",0.0804348,-0.0170732,-0.2124,0,4,partial,28.9,15.6,12.4,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 2); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (manageable, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 2); adrenal gland: 9.4 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 4); stomach: 6.4 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 4); rectum: 4.5 nTPM (protected, limit 2); liver: 4.1 nTPM (vital, limit 2); small intestine: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198919,DZIP3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 74.6667% (minimum 75%, Missing); basal ganglia: 67.8788% (minimum 75%, Missing); cerebellum: 70.2929% (minimum 75%, Missing); cerebral cortex: 59.7865% (minimum 75%, Missing); choroid plexus: 60.7595% (minimum 75%, Missing); hippocampal formation: 72.4138% (minimum 75%, Missing); hypothalamus: 65.3696% (minimum 75%, Missing); pituitary gland: 58.4348% (minimum 75%, Missing); retina: 53.7600% (minimum 75%, Missing); skeletal muscle: 73.8462% (minimum 75%, Missing); tongue: 68.2927% (minimum 70%, Missing)",0.0804348,-0.0170732,-0.2124,0,4,partial,28.9,15.6,12.4,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 3); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (manageable, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 3); adrenal gland: 9.4 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 4); stomach: 6.4 nTPM (protected, limit 3); lung: 6.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); urinary bladder: 5 nTPM (protected, limit 4); rectum: 4.5 nTPM (protected, limit 3); liver: 4.1 nTPM (vital, limit 2); small intestine: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198919,DZIP3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 74.6667% (minimum 75%, Missing); basal ganglia: 67.8788% (minimum 75%, Missing); cerebellum: 70.2929% (minimum 75%, Missing); cerebral cortex: 59.7865% (minimum 75%, Missing); choroid plexus: 60.7595% (minimum 75%, Missing); hippocampal formation: 72.4138% (minimum 75%, Missing); hypothalamus: 65.3696% (minimum 75%, Missing); pituitary gland: 58.4348% (minimum 75%, Missing); retina: 53.7600% (minimum 75%, Missing); skeletal muscle: 73.8462% (minimum 75%, Missing); tongue: 68.2927% (minimum 70%, Missing)",0.0804348,-0.0170732,-0.2124,0,4,partial,28.9,15.6,12.4,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 3); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (manageable, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 3); adrenal gland: 9.4 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 4); stomach: 6.4 nTPM (protected, limit 3); lung: 6.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); urinary bladder: 5 nTPM (protected, limit 4); rectum: 4.5 nTPM (protected, limit 3); liver: 4.1 nTPM (vital, limit 2); small intestine: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198919,DZIP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 74.6667% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 67.8788% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.2929% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 59.7865% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.7595% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 72.4138% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.3696% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 58.4348% (minimum 75%, Baseline (adaptation disabled)); retina: 53.7600% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 73.8462% (minimum 75%, Baseline (adaptation disabled)); tongue: 68.2927% (minimum 70%, Baseline (adaptation disabled))",0.0804348,-0.0170732,-0.2124,0,4,partial,28.9,15.6,12.4,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 3); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (manageable, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 3); adrenal gland: 9.4 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); spleen: 8.1 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 3); stomach: 6.4 nTPM (protected, limit 3); lung: 6.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); urinary bladder: 5 nTPM (protected, limit 3); rectum: 4.5 nTPM (protected, limit 3); liver: 4.1 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198919,DZIP3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 43.3333% (minimum 99%, Missing); basal ganglia: 40.6250% (minimum 99%, Missing); cerebellum: 76.4706% (minimum 99%, Missing); cerebral cortex: 44.8276% (minimum 99%, Missing); hippocampal formation: 44.8276% (minimum 99%, Missing); hypothalamus: 56.5217% (minimum 99%, Missing); lymph node: 81.2500% (minimum 97%, Missing); midbrain: 44.8276% (minimum 99%, Missing); small intestine: 92.8571% (minimum 99%, Missing); spinal cord: 68.4211% (minimum 99%, Missing); thyroid gland: 92.8571% (minimum 95%, Missing)",-0.0214286,-0.1575,-0.58375,0,80,unavailable,1.9,0.3,0.1,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,,,ENSG00000198930,CSAG1,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 43.3333% (minimum 75%, Missing); basal ganglia: 40.6250% (minimum 75%, Missing); cerebral cortex: 44.8276% (minimum 75%, Missing); hippocampal formation: 44.8276% (minimum 75%, Missing); hypothalamus: 56.5217% (minimum 75%, Missing); midbrain: 44.8276% (minimum 75%, Missing); spinal cord: 68.4211% (minimum 75%, Missing)",0.278571,0.1125,-0.34375,0,80,unavailable,1.9,0.3,0.1,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,,,ENSG00000198930,CSAG1,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 43.3333% (minimum 75%, Missing); basal ganglia: 40.6250% (minimum 75%, Missing); cerebral cortex: 44.8276% (minimum 75%, Missing); hippocampal formation: 44.8276% (minimum 75%, Missing); hypothalamus: 56.5217% (minimum 75%, Missing); midbrain: 44.8276% (minimum 75%, Missing); spinal cord: 68.4211% (minimum 75%, Missing)",0.278571,0.1125,-0.34375,0,80,unavailable,1.9,0.3,0.1,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,,,ENSG00000198930,CSAG1,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 43.3333% (minimum 75%, Missing); basal ganglia: 40.6250% (minimum 75%, Missing); cerebral cortex: 44.8276% (minimum 75%, Missing); hippocampal formation: 44.8276% (minimum 75%, Missing); hypothalamus: 56.5217% (minimum 75%, Missing); midbrain: 44.8276% (minimum 75%, Missing); spinal cord: 68.4211% (minimum 75%, Missing)",0.278571,0.1125,-0.34375,0,80,unavailable,1.9,0.3,0.1,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,,,ENSG00000198930,CSAG1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 43.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 40.6250% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 44.8276% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 44.8276% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 56.5217% (minimum 75%, Baseline (adaptation disabled)); midbrain: 44.8276% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 68.4211% (minimum 75%, Baseline (adaptation disabled))",0.278571,0.1125,-0.34375,0,80,unavailable,1.9,0.3,0.1,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,,,ENSG00000198930,CSAG1,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.1677% (minimum 99%, Missing); amygdala: 69.6594% (minimum 99%, Missing); basal ganglia: 63.0252% (minimum 99%, Missing); bone marrow: 93.5551% (minimum 95%, Enhanced); cerebellum: 88.5827% (minimum 95%, Enhanced); cerebral cortex: 67.7711% (minimum 99%, Missing); choroid plexus: 52.2648% (minimum 99%, Missing); heart muscle: 96.3597% (minimum 99%, Missing); hippocampal formation: 68.7023% (minimum 99%, Missing); hypothalamus: 74.8752% (minimum 99%, Missing); kidney: 60.8108% (minimum 99%, Missing); liver: 55.3506% (minimum 99%, Missing); lung: 94.5378% (minimum 95%, Enhanced); midbrain: 65.5977% (minimum 99%, Missing); pituitary gland: 91.8367% (minimum 99%, Missing); retina: 65.0289% (minimum 99%, Missing); skeletal muscle: 90.1804% (minimum 99%, Missing); small intestine: 98.0392% (minimum 99%, Missing); smooth muscle: 91.8367% (minimum 95%, Enhanced); spinal cord: 66.7656% (minimum 99%, Missing); tongue: 95.3390% (minimum 97%, Missing)",0.0368421,-0.0166102,-0.467352,0,2,partial,41.1,9.8,23.8,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198948,MFAP3L,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 69.6594% (minimum 75%, Missing); basal ganglia: 63.0252% (minimum 75%, Missing); cerebral cortex: 67.7711% (minimum 75%, Missing); choroid plexus: 52.2648% (minimum 75%, Missing); hippocampal formation: 68.7023% (minimum 75%, Missing); hypothalamus: 74.8752% (minimum 75%, Missing); kidney: 60.8108% (minimum 75%, Missing); liver: 55.3506% (minimum 75%, Missing); midbrain: 65.5977% (minimum 75%, Missing); retina: 65.0289% (minimum 75%, Missing); spinal cord: 66.7656% (minimum 75%, Missing)",0.15407,0.25339,-0.227352,0,2,partial,41.1,9.8,23.8,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198948,MFAP3L,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 69.6594% (minimum 75%, Missing); basal ganglia: 63.0252% (minimum 75%, Missing); cerebral cortex: 67.7711% (minimum 75%, Missing); choroid plexus: 52.2648% (minimum 75%, Missing); hippocampal formation: 68.7023% (minimum 75%, Missing); hypothalamus: 74.8752% (minimum 75%, Missing); kidney: 60.8108% (minimum 75%, Missing); liver: 55.3506% (minimum 75%, Missing); midbrain: 65.5977% (minimum 75%, Missing); retina: 65.0289% (minimum 75%, Missing); spinal cord: 66.7656% (minimum 75%, Missing)",0.15407,0.25339,-0.227352,0,2,partial,41.1,9.8,23.8,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198948,MFAP3L,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 69.6594% (minimum 75%, Missing); basal ganglia: 63.0252% (minimum 75%, Missing); cerebral cortex: 67.7711% (minimum 75%, Missing); choroid plexus: 52.2648% (minimum 75%, Missing); hippocampal formation: 68.7023% (minimum 75%, Missing); hypothalamus: 74.8752% (minimum 75%, Missing); kidney: 60.8108% (minimum 75%, Missing); liver: 55.3506% (minimum 75%, Missing); midbrain: 65.5977% (minimum 75%, Missing); retina: 65.0289% (minimum 75%, Missing); spinal cord: 66.7656% (minimum 75%, Missing)",0.15407,0.25339,-0.227352,0,2,partial,41.1,9.8,23.8,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198948,MFAP3L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 69.6594% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 63.0252% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 67.7711% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 52.2648% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.7023% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.8752% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.8108% (minimum 75%, Baseline (adaptation disabled)); liver: 55.3506% (minimum 75%, Baseline (adaptation disabled)); midbrain: 65.5977% (minimum 75%, Baseline (adaptation disabled)); retina: 65.0289% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.7656% (minimum 75%, Baseline (adaptation disabled))",0.00406977,0.121168,-0.227352,0,2,partial,41.1,9.8,23.8,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); skin: 23.8 nTPM (manageable, limit 5); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 3); parathyroid gland: 6.3 nTPM (protected, limit 3); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000198948,MFAP3L,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Missing); adrenal gland: 70.0000% (minimum 99%, Missing); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 81.3953% (minimum 99%, Missing); bone marrow: 68.6275% (minimum 99%, Missing); cerebellum: 64.8148% (minimum 99%, Missing); cerebral cortex: 84.6774% (minimum 99%, Missing); choroid plexus: 78.9474% (minimum 99%, Missing); colon: 73.4266% (minimum 97%, Missing); duodenum: 73.4266% (minimum 99%, Missing); esophagus: 71.9178% (minimum 97%, Missing); heart muscle: 82.0312% (minimum 99%, Missing); hippocampal formation: 82.0312% (minimum 99%, Missing); hypothalamus: 82.6772% (minimum 99%, Missing); kidney: 63.6364% (minimum 99%, Missing); liver: 82.0312% (minimum 99%, Missing); lung: 76.0870% (minimum 99%, Missing); lymph node: 57.6923% (minimum 97%, Missing); midbrain: 84.6774% (minimum 99%, Missing); pancreas: 64.0244% (minimum 99%, Missing); parathyroid gland: 43.5685% (minimum 97%, Missing); pituitary gland: 66.0377% (minimum 99%, Missing); rectum: 67.7419% (minimum 97%, Missing); retina: 68.6275% (minimum 99%, Missing); salivary gland: 70.4698% (minimum 97%, Missing); skeletal muscle: 91.3043% (minimum 99%, Missing); skin: 56.1497% (minimum 95%, Missing); small intestine: 66.8790% (minimum 99%, Missing); smooth muscle: 80.7692% (minimum 99%, Missing); spinal cord: 82.6772% (minimum 99%, Missing); spleen: 62.8743% (minimum 95%, Missing); stomach: 66.0377% (minimum 97%, Missing); thymus: 62.5000% (minimum 95%, Missing); thyroid gland: 67.3077% (minimum 95%, Missing); tongue: 86.0656% (minimum 97%, Missing); urinary bladder: 69.0789% (minimum 97%, Missing)",-0.388503,-0.534315,-0.353636,0,80,unavailable,6,13.6,8.2,"parathyroid gland: 13.6 nTPM (protected, limit 2); skin: 8.2 nTPM (manageable, limit 5); lymph node: 7.7 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); spleen: 6.2 nTPM (manageable, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203326,ZNF525,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); bone marrow: 68.6275% (minimum 75%, Missing); cerebellum: 64.8148% (minimum 75%, Missing); duodenum: 73.4266% (minimum 75%, Missing); kidney: 63.6364% (minimum 75%, Missing); lymph node: 57.6923% (minimum 70%, Missing); pancreas: 64.0244% (minimum 75%, Missing); parathyroid gland: 43.5685% (minimum 70%, Missing); pituitary gland: 66.0377% (minimum 75%, Missing); rectum: 67.7419% (minimum 70%, Missing); retina: 68.6275% (minimum 75%, Missing); skin: 56.1497% (minimum 65%, Missing); small intestine: 66.8790% (minimum 75%, Missing); spleen: 62.8743% (minimum 65%, Missing); stomach: 66.0377% (minimum 70%, Missing); thymus: 62.5000% (minimum 65%, Missing); urinary bladder: 69.0789% (minimum 70%, Missing)",-0.0885027,-0.264315,-0.113636,0,80,unavailable,6,13.6,8.2,"parathyroid gland: 13.6 nTPM (protected, limit 2); skin: 8.2 nTPM (manageable, limit 5); lymph node: 7.7 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); spleen: 6.2 nTPM (manageable, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203326,ZNF525,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); bone marrow: 68.6275% (minimum 75%, Missing); cerebellum: 64.8148% (minimum 75%, Missing); duodenum: 73.4266% (minimum 75%, Missing); kidney: 63.6364% (minimum 75%, Missing); lymph node: 57.6923% (minimum 70%, Missing); pancreas: 64.0244% (minimum 75%, Missing); parathyroid gland: 43.5685% (minimum 70%, Missing); pituitary gland: 66.0377% (minimum 75%, Missing); rectum: 67.7419% (minimum 70%, Missing); retina: 68.6275% (minimum 75%, Missing); skin: 56.1497% (minimum 65%, Missing); small intestine: 66.8790% (minimum 75%, Missing); spleen: 62.8743% (minimum 65%, Missing); stomach: 66.0377% (minimum 70%, Missing); thymus: 62.5000% (minimum 65%, Missing); urinary bladder: 69.0789% (minimum 70%, Missing)",-0.0885027,-0.264315,-0.113636,0,80,unavailable,6,13.6,8.2,"parathyroid gland: 13.6 nTPM (protected, limit 3); skin: 8.2 nTPM (manageable, limit 5); lymph node: 7.7 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); spleen: 6.2 nTPM (manageable, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); adrenal gland: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203326,ZNF525,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); bone marrow: 68.6275% (minimum 75%, Missing); cerebellum: 64.8148% (minimum 75%, Missing); duodenum: 73.4266% (minimum 75%, Missing); kidney: 63.6364% (minimum 75%, Missing); lymph node: 57.6923% (minimum 70%, Missing); pancreas: 64.0244% (minimum 75%, Missing); parathyroid gland: 43.5685% (minimum 70%, Missing); pituitary gland: 66.0377% (minimum 75%, Missing); rectum: 67.7419% (minimum 70%, Missing); retina: 68.6275% (minimum 75%, Missing); skin: 56.1497% (minimum 65%, Missing); small intestine: 66.8790% (minimum 75%, Missing); spleen: 62.8743% (minimum 65%, Missing); stomach: 66.0377% (minimum 70%, Missing); thymus: 62.5000% (minimum 65%, Missing); urinary bladder: 69.0789% (minimum 70%, Missing)",-0.0885027,-0.264315,-0.113636,0,80,unavailable,6,13.6,8.2,"parathyroid gland: 13.6 nTPM (protected, limit 3); skin: 8.2 nTPM (manageable, limit 5); lymph node: 7.7 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); spleen: 6.2 nTPM (manageable, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); adrenal gland: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203326,ZNF525,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 68.6275% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.8148% (minimum 75%, Baseline (adaptation disabled)); duodenum: 73.4266% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.6364% (minimum 75%, Baseline (adaptation disabled)); lymph node: 57.6923% (minimum 70%, Baseline (adaptation disabled)); pancreas: 64.0244% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 43.5685% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 66.0377% (minimum 75%, Baseline (adaptation disabled)); rectum: 67.7419% (minimum 70%, Baseline (adaptation disabled)); retina: 68.6275% (minimum 75%, Baseline (adaptation disabled)); skin: 56.1497% (minimum 65%, Baseline (adaptation disabled)); small intestine: 66.8790% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.8743% (minimum 65%, Baseline (adaptation disabled)); stomach: 66.0377% (minimum 70%, Baseline (adaptation disabled)); thymus: 62.5000% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 69.0789% (minimum 70%, Baseline (adaptation disabled))",-0.0885027,-0.264315,-0.113636,0,80,unavailable,6,13.6,8.2,"parathyroid gland: 13.6 nTPM (protected, limit 3); skin: 8.2 nTPM (manageable, limit 5); lymph node: 7.7 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); spleen: 6.2 nTPM (manageable, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); adrenal gland: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203326,ZNF525,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3125% (minimum 95%, Missing); adrenal gland: 73.7705% (minimum 99%, Missing); amygdala: 75.2508% (minimum 99%, Missing); basal ganglia: 76.7918% (minimum 99%, Missing); bone marrow: 62.6741% (minimum 98%, Approved); cerebellum: 88.9328% (minimum 99%, Missing); cerebral cortex: 74.5033% (minimum 99%, Missing); choroid plexus: 52.5701% (minimum 99%, Missing); colon: 81.2274% (minimum 97%, Missing); duodenum: 87.5486% (minimum 99%, Missing); esophagus: 71.4286% (minimum 97%, Missing); heart muscle: 69.2308% (minimum 99%, Missing); hippocampal formation: 73.2899% (minimum 99%, Missing); hypothalamus: 76.7918% (minimum 99%, Missing); kidney: 74.5033% (minimum 99%, Missing); liver: 85.5513% (minimum 99%, Missing); lung: 69.2308% (minimum 99%, Missing); lymph node: 72.8155% (minimum 97%, Missing); midbrain: 70.5329% (minimum 99%, Missing); pancreas: 75.7576% (minimum 99%, Missing); parathyroid gland: 69.2308% (minimum 97%, Missing); pituitary gland: 79.2254% (minimum 99%, Missing); rectum: 67.5676% (minimum 97%, Missing); retina: 59.2105% (minimum 99%, Missing); salivary gland: 75.7576% (minimum 97%, Missing); skeletal muscle: 55.4187% (minimum 99%, Missing); skin: 78.9474% (minimum 95%, Missing); small intestine: 79.2254% (minimum 99%, Missing); smooth muscle: 71.6561% (minimum 99%, Missing); spinal cord: 69.0184% (minimum 99%, Missing); spleen: 77.5862% (minimum 95%, Missing); stomach: 70.9779% (minimum 97%, Missing); thymus: 80.3571% (minimum 95%, Missing); thyroid gland: 51.2528% (minimum 95%, Missing); tongue: 80.6452% (minimum 97%, Missing); urinary bladder: 78.6713% (minimum 97%, Missing)",-0.437472,-0.294324,-0.464299,0,1,partial,20.3,10.8,21.4,"thyroid gland: 21.4 nTPM (manageable, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 2); rectum: 10.8 nTPM (protected, limit 2); spinal cord: 10.1 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 2); lung: 10 nTPM (vital, limit 1); adipose tissue: 9.5 nTPM (manageable, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 2); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); salivary gland: 7.2 nTPM (protected, limit 2); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.1 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203666,EFCAB2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.7705% (minimum 75%, Missing); bone marrow: 62.6741% (minimum 70%, Approved); cerebral cortex: 74.5033% (minimum 75%, Missing); choroid plexus: 52.5701% (minimum 75%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 73.2899% (minimum 75%, Missing); kidney: 74.5033% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); midbrain: 70.5329% (minimum 75%, Missing); parathyroid gland: 69.2308% (minimum 70%, Missing); rectum: 67.5676% (minimum 70%, Missing); retina: 59.2105% (minimum 75%, Missing); skeletal muscle: 55.4187% (minimum 75%, Missing); smooth muscle: 71.6561% (minimum 75%, Missing); spinal cord: 69.0184% (minimum 75%, Missing); thyroid gland: 51.2528% (minimum 65%, Missing)",-0.137472,-0.0243243,-0.224299,0,1,partial,20.3,10.8,21.4,"thyroid gland: 21.4 nTPM (manageable, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 2); rectum: 10.8 nTPM (protected, limit 2); spinal cord: 10.1 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 2); lung: 10 nTPM (vital, limit 1); adipose tissue: 9.5 nTPM (manageable, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 2); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); salivary gland: 7.2 nTPM (protected, limit 2); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.1 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203666,EFCAB2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.7705% (minimum 75%, Missing); bone marrow: 62.6741% (minimum 70%, Approved); cerebral cortex: 74.5033% (minimum 75%, Missing); choroid plexus: 52.5701% (minimum 75%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 73.2899% (minimum 75%, Missing); kidney: 74.5033% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); midbrain: 70.5329% (minimum 75%, Missing); parathyroid gland: 69.2308% (minimum 70%, Missing); rectum: 67.5676% (minimum 70%, Missing); retina: 59.2105% (minimum 75%, Missing); skeletal muscle: 55.4187% (minimum 75%, Missing); smooth muscle: 71.6561% (minimum 75%, Missing); spinal cord: 69.0184% (minimum 75%, Missing); thyroid gland: 51.2528% (minimum 65%, Missing)",-0.137472,-0.0243243,-0.224299,0,1,partial,20.3,10.8,21.4,"thyroid gland: 21.4 nTPM (manageable, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 2); rectum: 10.8 nTPM (protected, limit 3); spinal cord: 10.1 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 3); lung: 10 nTPM (vital, limit 1); adipose tissue: 9.5 nTPM (manageable, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 3); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); salivary gland: 7.2 nTPM (protected, limit 3); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.1 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203666,EFCAB2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.7705% (minimum 75%, Missing); bone marrow: 62.6741% (minimum 70%, Approved); cerebral cortex: 74.5033% (minimum 75%, Missing); choroid plexus: 52.5701% (minimum 75%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 73.2899% (minimum 75%, Missing); kidney: 74.5033% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); midbrain: 70.5329% (minimum 75%, Missing); parathyroid gland: 69.2308% (minimum 70%, Missing); rectum: 67.5676% (minimum 70%, Missing); retina: 59.2105% (minimum 75%, Missing); skeletal muscle: 55.4187% (minimum 75%, Missing); smooth muscle: 71.6561% (minimum 75%, Missing); spinal cord: 69.0184% (minimum 75%, Missing); thyroid gland: 51.2528% (minimum 65%, Missing)",-0.137472,-0.0243243,-0.224299,0,1,partial,20.3,10.8,21.4,"thyroid gland: 21.4 nTPM (manageable, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 2); rectum: 10.8 nTPM (protected, limit 3); spinal cord: 10.1 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 3); lung: 10 nTPM (vital, limit 1); adipose tissue: 9.5 nTPM (manageable, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 3); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); salivary gland: 7.2 nTPM (protected, limit 3); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.1 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203666,EFCAB2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.7705% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 62.6741% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 74.5033% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 52.5701% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 69.2308% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.2899% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.5033% (minimum 75%, Baseline (adaptation disabled)); lung: 69.2308% (minimum 75%, Baseline (adaptation disabled)); midbrain: 70.5329% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 69.2308% (minimum 70%, Baseline (adaptation disabled)); rectum: 67.5676% (minimum 70%, Baseline (adaptation disabled)); retina: 59.2105% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 55.4187% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.6561% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.0184% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 51.2528% (minimum 65%, Baseline (adaptation disabled))",-0.137472,-0.0243243,-0.224299,0,1,partial,20.3,10.8,21.4,"thyroid gland: 21.4 nTPM (manageable, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 3); spinal cord: 10.1 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 3); lung: 10 nTPM (vital, limit 1); adipose tissue: 9.5 nTPM (manageable, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 3); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); salivary gland: 7.2 nTPM (protected, limit 3); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.1 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203666,EFCAB2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.0000% (minimum 95%, Missing); adrenal gland: 47.3684% (minimum 99%, Missing); amygdala: 27.6923% (minimum 99%, Missing); basal ganglia: 29.2683% (minimum 99%, Missing); cerebellum: 17.7340% (minimum 99%, Missing); cerebral cortex: 12.5436% (minimum 99%, Missing); choroid plexus: 97.2973% (minimum 99%, Missing); colon: 61.0169% (minimum 97%, Missing); duodenum: 87.8049% (minimum 99%, Missing); esophagus: 56.2500% (minimum 97%, Missing); heart muscle: 67.9245% (minimum 99%, Missing); hippocampal formation: 21.3018% (minimum 99%, Missing); hypothalamus: 35.6436% (minimum 99%, Missing); kidney: 40.4494% (minimum 99%, Missing); liver: 17.2249% (minimum 99%, Missing); lung: 69.2308% (minimum 99%, Missing); midbrain: 45.5696% (minimum 99%, Missing); pancreas: 55.3846% (minimum 99%, Missing); parathyroid gland: 94.7368% (minimum 97%, Missing); pituitary gland: 41.8605% (minimum 99%, Missing); retina: 85.7143% (minimum 99%, Missing); salivary gland: 63.1579% (minimum 97%, Missing); skeletal muscle: 65.4545% (minimum 99%, Missing); skin: 66.6667% (minimum 95%, Missing); small intestine: 52.9412% (minimum 99%, Missing); smooth muscle: 92.3077% (minimum 99%, Missing); spinal cord: 52.1739% (minimum 99%, Missing); spleen: 43.9024% (minimum 95%, Missing); stomach: 50.7042% (minimum 97%, Missing); thyroid gland: 51.4286% (minimum 95%, Missing); urinary bladder: 69.2308% (minimum 97%, Missing)",-0.510976,-0.462958,-0.864564,0,80,unavailable,25.1,3.5,4.6,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203772,SPRN,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 75%, Missing); amygdala: 27.6923% (minimum 75%, Missing); basal ganglia: 29.2683% (minimum 75%, Missing); cerebellum: 17.7340% (minimum 75%, Missing); cerebral cortex: 12.5436% (minimum 75%, Missing); colon: 61.0169% (minimum 70%, Missing); esophagus: 56.2500% (minimum 70%, Missing); heart muscle: 67.9245% (minimum 75%, Missing); hippocampal formation: 21.3018% (minimum 75%, Missing); hypothalamus: 35.6436% (minimum 75%, Missing); kidney: 40.4494% (minimum 75%, Missing); liver: 17.2249% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); midbrain: 45.5696% (minimum 75%, Missing); pancreas: 55.3846% (minimum 75%, Missing); pituitary gland: 41.8605% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skeletal muscle: 65.4545% (minimum 75%, Missing); small intestine: 52.9412% (minimum 75%, Missing); spinal cord: 52.1739% (minimum 75%, Missing); spleen: 43.9024% (minimum 65%, Missing); stomach: 50.7042% (minimum 70%, Missing); thyroid gland: 51.4286% (minimum 65%, Missing); urinary bladder: 69.2308% (minimum 70%, Missing)",-0.210976,-0.192958,-0.624564,0,80,unavailable,25.1,3.5,4.6,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203772,SPRN,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 75%, Missing); amygdala: 27.6923% (minimum 75%, Missing); basal ganglia: 29.2683% (minimum 75%, Missing); cerebellum: 17.7340% (minimum 75%, Missing); cerebral cortex: 12.5436% (minimum 75%, Missing); colon: 61.0169% (minimum 70%, Missing); esophagus: 56.2500% (minimum 70%, Missing); heart muscle: 67.9245% (minimum 75%, Missing); hippocampal formation: 21.3018% (minimum 75%, Missing); hypothalamus: 35.6436% (minimum 75%, Missing); kidney: 40.4494% (minimum 75%, Missing); liver: 17.2249% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); midbrain: 45.5696% (minimum 75%, Missing); pancreas: 55.3846% (minimum 75%, Missing); pituitary gland: 41.8605% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skeletal muscle: 65.4545% (minimum 75%, Missing); small intestine: 52.9412% (minimum 75%, Missing); spinal cord: 52.1739% (minimum 75%, Missing); spleen: 43.9024% (minimum 65%, Missing); stomach: 50.7042% (minimum 70%, Missing); thyroid gland: 51.4286% (minimum 65%, Missing); urinary bladder: 69.2308% (minimum 70%, Missing)",-0.210976,-0.192958,-0.624564,0,80,unavailable,25.1,3.5,4.6,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203772,SPRN,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 75%, Missing); amygdala: 27.6923% (minimum 75%, Missing); basal ganglia: 29.2683% (minimum 75%, Missing); cerebellum: 17.7340% (minimum 75%, Missing); cerebral cortex: 12.5436% (minimum 75%, Missing); colon: 61.0169% (minimum 70%, Missing); esophagus: 56.2500% (minimum 70%, Missing); heart muscle: 67.9245% (minimum 75%, Missing); hippocampal formation: 21.3018% (minimum 75%, Missing); hypothalamus: 35.6436% (minimum 75%, Missing); kidney: 40.4494% (minimum 75%, Missing); liver: 17.2249% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); midbrain: 45.5696% (minimum 75%, Missing); pancreas: 55.3846% (minimum 75%, Missing); pituitary gland: 41.8605% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skeletal muscle: 65.4545% (minimum 75%, Missing); small intestine: 52.9412% (minimum 75%, Missing); spinal cord: 52.1739% (minimum 75%, Missing); spleen: 43.9024% (minimum 65%, Missing); stomach: 50.7042% (minimum 70%, Missing); thyroid gland: 51.4286% (minimum 65%, Missing); urinary bladder: 69.2308% (minimum 70%, Missing)",-0.210976,-0.192958,-0.624564,0,80,unavailable,25.1,3.5,4.6,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203772,SPRN,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 75%, Baseline (adaptation disabled)); amygdala: 27.6923% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 29.2683% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 17.7340% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 12.5436% (minimum 75%, Baseline (adaptation disabled)); colon: 61.0169% (minimum 70%, Baseline (adaptation disabled)); esophagus: 56.2500% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 67.9245% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 21.3018% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 35.6436% (minimum 75%, Baseline (adaptation disabled)); kidney: 40.4494% (minimum 75%, Baseline (adaptation disabled)); liver: 17.2249% (minimum 75%, Baseline (adaptation disabled)); lung: 69.2308% (minimum 75%, Baseline (adaptation disabled)); midbrain: 45.5696% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.3846% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 41.8605% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.1579% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 65.4545% (minimum 75%, Baseline (adaptation disabled)); small intestine: 52.9412% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 52.1739% (minimum 75%, Baseline (adaptation disabled)); spleen: 43.9024% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.7042% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 51.4286% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 69.2308% (minimum 70%, Baseline (adaptation disabled))",-0.210976,-0.192958,-0.624564,0,80,unavailable,25.1,3.5,4.6,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203772,SPRN,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.4008% (minimum 99%, Missing); amygdala: 85.4285% (minimum 99%, Missing); basal ganglia: 85.8156% (minimum 99%, Missing); cerebellum: 94.9020% (minimum 99%, Missing); cerebral cortex: 88.0890% (minimum 99%, Missing); choroid plexus: 81.0871% (minimum 99%, Missing); colon: 95.5263% (minimum 97%, Missing); heart muscle: 86.5488% (minimum 99%, Missing); hippocampal formation: 87.0330% (minimum 99%, Missing); hypothalamus: 86.1210% (minimum 99%, Missing); kidney: 93.8793% (minimum 99%, Missing); liver: 94.7368% (minimum 99%, Missing); lung: 96.7140% (minimum 99%, Missing); midbrain: 82.8294% (minimum 99%, Missing); pancreas: 98.1302% (minimum 99%, Missing); parathyroid gland: 91.2060% (minimum 97%, Missing); pituitary gland: 87.1374% (minimum 99%, Missing); retina: 92.7006% (minimum 99%, Missing); skeletal muscle: 97.0588% (minimum 99%, Missing); small intestine: 98.3740% (minimum 99%, Missing); smooth muscle: 96.0953% (minimum 99%, Missing); spinal cord: 81.2990% (minimum 99%, Missing); stomach: 96.0106% (minimum 97%, Missing); tongue: 96.7355% (minimum 97%, Missing); urinary bladder: 95.9471% (minimum 97%, Missing)",0.00526316,-0.0579397,-0.179129,0,80,unavailable,101.6,42,20.4,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 2); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); colon: 20.4 nTPM (protected, limit 2); urinary bladder: 18.4 nTPM (protected, limit 2); stomach: 18.1 nTPM (protected, limit 2); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (manageable, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 13.2 nTPM (vital, limit 1); thymus: 10.6 nTPM (manageable, limit 5); salivary gland: 8.7 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 2); rectum: 5.2 nTPM (protected, limit 2); spleen: 5.1 nTPM (manageable, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203778,FAM229B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305263,0.21206,0.0608712,0,80,unavailable,101.6,42,20.4,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 2); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); colon: 20.4 nTPM (protected, limit 2); urinary bladder: 18.4 nTPM (protected, limit 2); stomach: 18.1 nTPM (protected, limit 2); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (manageable, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 13.2 nTPM (vital, limit 1); thymus: 10.6 nTPM (manageable, limit 5); salivary gland: 8.7 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 2); rectum: 5.2 nTPM (protected, limit 2); spleen: 5.1 nTPM (manageable, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203778,FAM229B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305263,0.21206,0.0608712,0,80,unavailable,101.6,42,20.4,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 3); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); colon: 20.4 nTPM (protected, limit 3); urinary bladder: 18.4 nTPM (protected, limit 3); stomach: 18.1 nTPM (protected, limit 3); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (manageable, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 13.2 nTPM (vital, limit 1); thymus: 10.6 nTPM (manageable, limit 5); salivary gland: 8.7 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 3); rectum: 5.2 nTPM (protected, limit 3); spleen: 5.1 nTPM (manageable, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203778,FAM229B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305263,0.21206,0.0608712,0,80,unavailable,101.6,42,20.4,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 3); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); colon: 20.4 nTPM (protected, limit 3); urinary bladder: 18.4 nTPM (protected, limit 3); stomach: 18.1 nTPM (protected, limit 3); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (manageable, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 13.2 nTPM (vital, limit 1); thymus: 10.6 nTPM (manageable, limit 5); salivary gland: 8.7 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 3); rectum: 5.2 nTPM (protected, limit 3); spleen: 5.1 nTPM (manageable, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203778,FAM229B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305263,0.21206,0.0608712,0,80,unavailable,101.6,42,20.4,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 3); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); colon: 20.4 nTPM (protected, limit 3); urinary bladder: 18.4 nTPM (protected, limit 3); stomach: 18.1 nTPM (protected, limit 3); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (manageable, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 13.2 nTPM (vital, limit 1); thymus: 10.6 nTPM (manageable, limit 5); salivary gland: 8.7 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 3); rectum: 5.2 nTPM (protected, limit 3); spleen: 5.1 nTPM (manageable, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203778,FAM229B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.0068% (minimum 99%, Missing); amygdala: 91.3478% (minimum 99%, Missing); basal ganglia: 88.1220% (minimum 99%, Missing); bone marrow: 98.2111% (minimum 99%, Missing); cerebellum: 98.9189% (minimum 99%, Missing); cerebral cortex: 94.9827% (minimum 99%, Missing); choroid plexus: 45.2597% (minimum 99%, Missing); colon: 94.8187% (minimum 97%, Missing); duodenum: 95.9790% (minimum 99%, Missing); esophagus: 94.0068% (minimum 97%, Missing); heart muscle: 98.7410% (minimum 99%, Missing); hippocampal formation: 88.8350% (minimum 99%, Missing); hypothalamus: 85.2484% (minimum 99%, Missing); kidney: 90.5941% (minimum 99%, Missing); lung: 90.8940% (minimum 99%, Missing); midbrain: 92.7365% (minimum 99%, Missing); pancreas: 93.0508% (minimum 99%, Missing); parathyroid gland: 92.7365% (minimum 97%, Missing); pituitary gland: 88.4058% (minimum 99%, Missing); rectum: 92.4242% (minimum 97%, Missing); retina: 78.2051% (minimum 99%, Missing); salivary gland: 95.9790% (minimum 97%, Missing); skin: 90.7438% (minimum 95%, Missing); small intestine: 96.4851% (minimum 99%, Missing); smooth muscle: 97.6868% (minimum 99%, Missing); spinal cord: 94.4923% (minimum 99%, Missing); stomach: 91.3478% (minimum 97%, Missing); thyroid gland: 87.2814% (minimum 95%, Missing); urinary bladder: 96.1471% (minimum 97%, Missing)",-0.077186,-0.0565225,-0.537403,0,80,unavailable,66.4,5.2,8,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); lung: 5.5 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 2); amygdala: 5.2 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); cerebral cortex: 2.9 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203780,FANK1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.2597% (minimum 75%, Missing)",0.222814,0.213478,-0.297403,0,80,unavailable,66.4,5.2,8,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); lung: 5.5 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 2); amygdala: 5.2 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); cerebral cortex: 2.9 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203780,FANK1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.2597% (minimum 75%, Missing)",0.222814,0.213478,-0.297403,0,80,unavailable,66.4,5.2,8,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); lung: 5.5 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 3); amygdala: 5.2 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203780,FANK1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.2597% (minimum 75%, Missing)",0.222814,0.213478,-0.297403,0,80,unavailable,66.4,5.2,8,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); lung: 5.5 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 3); amygdala: 5.2 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203780,FANK1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.2597% (minimum 75%, Baseline (adaptation disabled))",0.222814,0.213478,-0.297403,0,80,unavailable,66.4,5.2,8,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); lung: 5.5 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 3); amygdala: 5.2 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203780,FANK1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.049908,0.03,0.00990798,0,1,partial,0.4,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203784,LELP1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349908,0.3,0.249908,0,1,partial,0.4,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203784,LELP1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349908,0.3,0.249908,0,1,partial,0.4,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203784,LELP1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349908,0.3,0.249908,0,1,partial,0.4,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203784,LELP1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.349724,0.299908,0.249632,0,1,partial,0.4,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203784,LELP1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203795,FAM24A,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203795,FAM24A,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203795,FAM24A,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203795,FAM24A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203795,FAM24A,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.4293% (minimum 99%, Missing); small intestine: 89.9522% (minimum 97%, Supported)",0.05,0.03,-0.0704785,0,5,partial,8.4,0.4,4.3,"small intestine: 8.4 nTPM (vital, limit 3); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203857,HSD3B1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.234293,0,5,partial,8.4,0.4,4.3,"small intestine: 8.4 nTPM (vital, limit 3); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203857,HSD3B1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.234293,0,5,partial,8.4,0.4,4.3,"small intestine: 8.4 nTPM (vital, limit 3); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203857,HSD3B1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.234293,0,5,partial,8.4,0.4,4.3,"small intestine: 8.4 nTPM (vital, limit 3); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203857,HSD3B1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.295912,0.294709,0.149522,0,5,partial,8.4,0.4,4.3,"small intestine: 8.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203857,HSD3B1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 96.5035% (minimum 99%, Missing); kidney: 97.1831% (minimum 98%, Approved); liver: 97.8723% (minimum 98%, Approved); pancreas: 93.8776% (minimum 98%, Approved); salivary gland: 89.0323% (minimum 95%, Approved)",0.0387755,-0.0596774,-0.0412245,0,4,partial,0.9,1.7,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203907,OOEP,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
True,compatible,,True,True,True,,0.338776,0.240323,0.215035,0,4,partial,0.9,1.7,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203907,OOEP,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
True,compatible,,True,True,True,,0.338776,0.240323,0.215035,0,4,partial,0.9,1.7,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203907,OOEP,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
True,compatible,,True,True,True,,0.338776,0.240323,0.215035,0,4,partial,0.9,1.7,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203907,OOEP,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
True,compatible,,True,True,True,,0.288776,0.190323,0.188776,0,4,partial,0.9,1.7,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203907,OOEP,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 95.2381% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing)",0.00238095,0.03,-0.19,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203909,DPPA5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.302381,0.3,0.05,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203909,DPPA5,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.302381,0.3,0.05,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203909,DPPA5,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.302381,0.3,0.05,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203909,DPPA5,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.302381,0.3,0.05,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203909,DPPA5,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.6486% (minimum 99%, Missing); cerebellum: 98.6486% (minimum 99%, Missing); cerebral cortex: 97.3333% (minimum 99%, Missing); pancreas: 96.0526% (minimum 99%, Missing); retina: 78.4946% (minimum 99%, Missing); skeletal muscle: 98.6486% (minimum 99%, Missing); skin: 92.4051% (minimum 95%, Missing)",-0.0259494,0.00333333,-0.205054,0,80,unavailable,2,0.2,0.6,"retina: 2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203910,C1orf146,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.274051,0.273333,0.0349462,0,80,unavailable,2,0.2,0.6,"retina: 2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203910,C1orf146,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.274051,0.273333,0.0349462,0,80,unavailable,2,0.2,0.6,"retina: 2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203910,C1orf146,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.274051,0.273333,0.0349462,0,80,unavailable,2,0.2,0.6,"retina: 2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203910,C1orf146,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.274051,0.273333,0.0349462,0,80,unavailable,2,0.2,0.6,"retina: 2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203910,C1orf146,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203923,SPANXN1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203923,SPANXN1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203923,SPANXN1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203923,SPANXN1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203923,SPANXN1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203926,SPANXA2,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203926,SPANXA2,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203926,SPANXA2,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203926,SPANXA2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203926,SPANXA2,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 95.5882% (minimum 99%, Missing)",0.05,0.03,-0.0341176,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203933,CXorf66,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.205882,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203933,CXorf66,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.205882,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203933,CXorf66,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.205882,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203933,CXorf66,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.205882,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203933,CXorf66,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.0292604,0.00815294,0,5,partial,0.8,0.2,0.1,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203942,C10orf62,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.29926,0.248153,0,5,partial,0.8,0.2,0.1,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203942,C10orf62,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.29926,0.248153,0,5,partial,0.8,0.2,0.1,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203942,C10orf62,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.29926,0.248153,0,5,partial,0.8,0.2,0.1,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203942,C10orf62,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34963,0.29926,0.247048,0,5,partial,0.8,0.2,0.1,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203942,C10orf62,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.1290% (minimum 99%, Missing); basal ganglia: 94.3038% (minimum 99%, Missing); cerebral cortex: 98.0263% (minimum 99%, Missing); choroid plexus: 84.6591% (minimum 99%, Missing); hippocampal formation: 95.5128% (minimum 99%, Missing); hypothalamus: 94.3038% (minimum 99%, Missing); lung: 93.7107% (minimum 99%, Missing); midbrain: 98.0263% (minimum 99%, Missing); retina: 82.7778% (minimum 99%, Missing); spinal cord: 98.6755% (minimum 99%, Missing)",0.05,0.0233333,-0.162222,0,80,unavailable,3.1,0.1,0,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203963,C1orf141,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293333,0.0777778,0,80,unavailable,3.1,0.1,0,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203963,C1orf141,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293333,0.0777778,0,80,unavailable,3.1,0.1,0,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203963,C1orf141,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293333,0.0777778,0,80,unavailable,3.1,0.1,0,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203963,C1orf141,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293333,0.0777778,0,80,unavailable,3.1,0.1,0,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203963,C1orf141,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000203970,DEFB110,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000203970,DEFB110,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000203970,DEFB110,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000203970,DEFB110,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000203970,DEFB110,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203989,RHOXF2B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203989,RHOXF2B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203989,RHOXF2B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203989,RHOXF2B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245169,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203989,RHOXF2B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.3684% (minimum 99%, Missing); cerebellum: 94.8718% (minimum 99%, Missing); choroid plexus: 92.5000% (minimum 99%, Missing); duodenum: 94.8718% (minimum 99%, Missing); esophagus: 86.0465% (minimum 97%, Missing); kidney: 56.9231% (minimum 99%, Missing); liver: 75.5102% (minimum 99%, Missing); lymph node: 94.8718% (minimum 97%, Missing); pituitary gland: 97.3684% (minimum 99%, Missing); retina: 94.8718% (minimum 99%, Missing); skeletal muscle: 97.3684% (minimum 99%, Missing); skin: 94.8718% (minimum 95%, Missing); thymus: 92.5000% (minimum 95%, Missing); thyroid gland: 62.7119% (minimum 95%, Missing)",-0.322881,-0.109535,-0.420769,0,80,unavailable,2.8,0.6,2.2,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203995,ZYG11A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 56.9231% (minimum 75%, Missing); thyroid gland: 62.7119% (minimum 65%, Missing)",-0.0228814,0.160465,-0.180769,0,80,unavailable,2.8,0.6,2.2,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203995,ZYG11A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 56.9231% (minimum 75%, Missing); thyroid gland: 62.7119% (minimum 65%, Missing)",-0.0228814,0.160465,-0.180769,0,80,unavailable,2.8,0.6,2.2,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203995,ZYG11A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 56.9231% (minimum 75%, Missing); thyroid gland: 62.7119% (minimum 65%, Missing)",-0.0228814,0.160465,-0.180769,0,80,unavailable,2.8,0.6,2.2,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203995,ZYG11A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 56.9231% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 62.7119% (minimum 65%, Baseline (adaptation disabled))",-0.0228814,0.160465,-0.180769,0,80,unavailable,2.8,0.6,2.2,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000203995,ZYG11A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0459677,0.03,0.01,0,80,unavailable,0,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204006,C1orf185,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345968,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204006,C1orf185,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345968,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204006,C1orf185,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345968,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204006,C1orf185,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345968,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204006,C1orf185,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204007,GLT6D1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204007,GLT6D1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204007,GLT6D1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204007,GLT6D1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204007,GLT6D1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 95.9877% (minimum 97%, Missing)",0.05,-0.0101235,0.01,0,80,unavailable,0,2.6,0,"salivary gland: 2.6 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204019,CT83,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.259877,0.25,0,80,unavailable,0,2.6,0,"salivary gland: 2.6 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204019,CT83,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.259877,0.25,0,80,unavailable,0,2.6,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204019,CT83,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.259877,0.25,0,80,unavailable,0,2.6,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204019,CT83,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.259877,0.25,0,80,unavailable,0,2.6,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204019,CT83,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.5507% (minimum 99%, Missing); basal ganglia: 98.5507% (minimum 99%, Missing); cerebellum: 93.1507% (minimum 99%, Missing); cerebral cortex: 97.1429% (minimum 99%, Missing); choroid plexus: 97.1429% (minimum 99%, Missing); duodenum: 95.7746% (minimum 99%, Missing); heart muscle: 98.5507% (minimum 99%, Missing); hippocampal formation: 97.1429% (minimum 99%, Missing); hypothalamus: 97.1429% (minimum 99%, Missing); kidney: 97.1429% (minimum 99%, Missing); liver: 93.1507% (minimum 99%, Missing); lung: 98.5507% (minimum 99%, Missing); lymph node: 95.7746% (minimum 97%, Missing); pancreas: 95.7746% (minimum 99%, Missing); pituitary gland: 98.5507% (minimum 99%, Missing); retina: 98.5507% (minimum 99%, Missing); salivary gland: 95.7746% (minimum 97%, Missing); skeletal muscle: 97.1429% (minimum 99%, Missing); small intestine: 98.5507% (minimum 99%, Missing); smooth muscle: 97.1429% (minimum 99%, Missing); thymus: 94.4444% (minimum 95%, Missing); thyroid gland: 93.1507% (minimum 95%, Missing)",-0.0184932,-0.0122535,-0.0584932,0,80,unavailable,0.5,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204022,LIPJ,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.281507,0.257746,0.181507,0,80,unavailable,0.5,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204022,LIPJ,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.281507,0.257746,0.181507,0,80,unavailable,0.5,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204022,LIPJ,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.281507,0.257746,0.181507,0,80,unavailable,0.5,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204022,LIPJ,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.281507,0.257746,0.181507,0,80,unavailable,0.5,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204022,LIPJ,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.000521327,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204025,TRPC5OS,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240521,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204025,TRPC5OS,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240521,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204025,TRPC5OS,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240521,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204025,TRPC5OS,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.240521,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204025,TRPC5OS,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.3984% (minimum 95%, Enhanced); amygdala: 85.8283% (minimum 99%, Missing); basal ganglia: 81.4394% (minimum 99%, Missing); cerebellum: 94.9227% (minimum 99%, Missing); cerebral cortex: 77.4775% (minimum 99%, Missing); choroid plexus: 87.7551% (minimum 99%, Missing); hippocampal formation: 83.6576% (minimum 99%, Missing); hypothalamus: 88.6598% (minimum 99%, Missing); kidney: 94.5055% (minimum 95%, Enhanced); midbrain: 93.8865% (minimum 99%, Missing); pituitary gland: 90.3361% (minimum 99%, Missing); retina: 96.6292% (minimum 99%, Missing); spinal cord: 98.1735% (minimum 99%, Missing)",0.05,0.0207834,-0.215225,0,12,partial,12.5,3.5,1,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 6); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204052,LRRC73,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.290783,0.0247748,0,12,partial,12.5,3.5,1,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 6); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204052,LRRC73,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.290783,0.0247748,0,12,partial,12.5,3.5,1,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 6); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204052,LRRC73,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.290783,0.0247748,0,12,partial,12.5,3.5,1,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 6); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204052,LRRC73,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327273,0.224731,0.0247748,0,12,partial,12.5,3.5,1,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); midbrain: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204052,LRRC73,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 94.1176% (minimum 99%, Missing); bone marrow: 88.8889% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 94.1176% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); esophagus: 94.1176% (minimum 97%, Missing); heart muscle: 84.2105% (minimum 99%, Missing); kidney: 94.1176% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lung: 84.2105% (minimum 99%, Missing); pancreas: 94.1176% (minimum 99%, Missing); rectum: 94.1176% (minimum 97%, Missing); salivary gland: 94.1176% (minimum 97%, Missing); skeletal muscle: 88.8889% (minimum 99%, Missing); skin: 94.1176% (minimum 95%, Missing); small intestine: 94.1176% (minimum 99%, Missing); spinal cord: 94.1176% (minimum 99%, Missing); spleen: 94.1176% (minimum 95%, Missing); stomach: 94.1176% (minimum 97%, Missing); thyroid gland: 94.1176% (minimum 95%, Missing); urinary bladder: 88.8889% (minimum 97%, Missing)",-0.15,-0.0811111,-0.19,0,2,partial,0.4,0.2,0.4,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204086,RPA4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.15,0.188889,0.05,0,2,partial,0.4,0.2,0.4,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204086,RPA4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.15,0.188889,0.05,0,2,partial,0.4,0.2,0.4,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204086,RPA4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.15,0.188889,0.05,0,2,partial,0.4,0.2,0.4,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204086,RPA4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.15,0.188889,0.05,0,2,partial,0.4,0.2,0.4,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204086,RPA4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 77.3553% (minimum 95%, Enhanced)",0.05,0.03,-0.176447,0,1,partial,173.3,1.5,0.1,"pancreas: 173.3 nTPM (vital, limit 6); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204140,CLPSL1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.173553,0,1,partial,173.3,1.5,0.1,"pancreas: 173.3 nTPM (vital, limit 6); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204140,CLPSL1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.173553,0,1,partial,173.3,1.5,0.1,"pancreas: 173.3 nTPM (vital, limit 6); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204140,CLPSL1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.173553,0,1,partial,173.3,1.5,0.1,"pancreas: 173.3 nTPM (vital, limit 6); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204140,CLPSL1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349831,0.297473,0.0235529,0,1,partial,173.3,1.5,0.1,"pancreas: 173.3 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204140,CLPSL1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.3214% (minimum 99%, Missing); lung: 98.1982% (minimum 99%, Missing); small intestine: 95.1965% (minimum 99%, Missing); spleen: 90.8333% (minimum 95%, Missing)",-0.0416667,0.0209091,-0.0380349,0,80,unavailable,1.1,0.2,2.2,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204165,CXorf65,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.258333,0.290909,0.201965,0,80,unavailable,1.1,0.2,2.2,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204165,CXorf65,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.258333,0.290909,0.201965,0,80,unavailable,1.1,0.2,2.2,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204165,CXorf65,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.258333,0.290909,0.201965,0,80,unavailable,1.1,0.2,2.2,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204165,CXorf65,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.258333,0.290909,0.201965,0,80,unavailable,1.1,0.2,2.2,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204165,CXorf65,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.0453271,0.03,0.01,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204193,TXNDC8,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345327,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204193,TXNDC8,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345327,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204193,TXNDC8,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345327,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204193,TXNDC8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345327,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204193,TXNDC8,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204246,OR13C3,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204246,OR13C3,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204246,OR13C3,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204246,OR13C3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204246,OR13C3,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204279,PAGE3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204279,PAGE3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204279,PAGE3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204279,PAGE3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204279,PAGE3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0.1,0.2,0.1,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204296,TSBP1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0.2,0.1,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204296,TSBP1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0.2,0.1,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204296,TSBP1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0.2,0.1,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204296,TSBP1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347033,0.294083,0.247033,0,1,partial,0.1,0.2,0.1,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204296,TSBP1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204300,TMEM225,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204300,TMEM225,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204300,TMEM225,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204300,TMEM225,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204300,TMEM225,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.1695% (minimum 95%, Missing); adrenal gland: 91.4089% (minimum 99%, Missing); amygdala: 88.3721% (minimum 99%, Missing); basal ganglia: 85.8065% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 93.6620% (minimum 99%, Missing); cerebral cortex: 89.2617% (minimum 99%, Missing); choroid plexus: 83.6478% (minimum 99%, Missing); colon: 90.7850% (minimum 97%, Missing); duodenum: 95.6835% (minimum 99%, Missing); esophagus: 93.9929% (minimum 97%, Missing); heart muscle: 93.3333% (minimum 99%, Missing); hippocampal formation: 87.7888% (minimum 99%, Missing); hypothalamus: 88.3721% (minimum 99%, Missing); kidney: 86.6450% (minimum 99%, Missing); liver: 86.9281% (minimum 99%, Missing); lung: 94.3262% (minimum 99%, Missing); lymph node: 93.6620% (minimum 97%, Missing); midbrain: 86.0841% (minimum 99%, Missing); pancreas: 94.3262% (minimum 99%, Missing); parathyroid gland: 96.0289% (minimum 97%, Missing); pituitary gland: 82.3529% (minimum 99%, Missing); rectum: 96.0289% (minimum 97%, Missing); retina: 81.0976% (minimum 99%, Missing); salivary gland: 91.0959% (minimum 97%, Missing); skeletal muscle: 88.9632% (minimum 99%, Missing); skin: 86.6450% (minimum 95%, Missing); small intestine: 93.9929% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 93.6620% (minimum 95%, Missing); stomach: 93.6620% (minimum 97%, Missing); thyroid gland: 88.0795% (minimum 95%, Missing); tongue: 96.7273% (minimum 97%, Missing); urinary bladder: 91.0959% (minimum 97%, Missing)",-0.0835505,-0.0621502,-0.179024,0,80,unavailable,6.2,2.7,4.1,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204311,PJVK,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.21645,0.20785,0.0609756,0,80,unavailable,6.2,2.7,4.1,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204311,PJVK,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.21645,0.20785,0.0609756,0,80,unavailable,6.2,2.7,4.1,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204311,PJVK,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.21645,0.20785,0.0609756,0,80,unavailable,6.2,2.7,4.1,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204311,PJVK,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.21645,0.20785,0.0609756,0,80,unavailable,6.2,2.7,4.1,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204311,PJVK,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6386% (minimum 99%, Missing); amygdala: 97.5520% (minimum 99%, Missing); basal ganglia: 97.9115% (minimum 99%, Missing); cerebral cortex: 97.6118% (minimum 99%, Missing); choroid plexus: 77.3411% (minimum 99%, Missing); heart muscle: 98.3344% (minimum 99%, Missing); hippocampal formation: 98.2132% (minimum 99%, Missing); hypothalamus: 97.3138% (minimum 99%, Missing); kidney: 97.7315% (minimum 99%, Missing); liver: 97.9717% (minimum 99%, Missing); lung: 94.4873% (minimum 99%, Missing); midbrain: 97.7315% (minimum 99%, Missing); pancreas: 97.6118% (minimum 99%, Missing); parathyroid gland: 96.1979% (minimum 97%, Missing); retina: 96.6646% (minimum 99%, Missing); spinal cord: 98.6386% (minimum 99%, Missing); thyroid gland: 93.8751% (minimum 95%, Missing)",-0.0112485,-0.00802052,-0.216589,0,80,unavailable,46.7,6.3,10.4,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); tongue: 2.4 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204334,ERICH2,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288751,0.261979,0.023411,0,80,unavailable,46.7,6.3,10.4,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); tongue: 2.4 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204334,ERICH2,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288751,0.261979,0.023411,0,80,unavailable,46.7,6.3,10.4,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204334,ERICH2,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288751,0.261979,0.023411,0,80,unavailable,46.7,6.3,10.4,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204334,ERICH2,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288751,0.261979,0.023411,0,80,unavailable,46.7,6.3,10.4,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204334,ERICH2,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204363,SPANXN5,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204363,SPANXN5,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204363,SPANXN5,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204363,SPANXN5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204363,SPANXN5,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0478166,0.0278166,0.00781659,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204379,XAGE1A,admission_only,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347817,0.297817,0.247817,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204379,XAGE1A,selectivity_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347817,0.297817,0.247817,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204379,XAGE1A,grid_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347817,0.297817,0.247817,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204379,XAGE1A,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347817,0.297817,0.247817,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204379,XAGE1A,current_fixed,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 97.2527% (minimum 99%, Missing); lung: 97.7901% (minimum 99%, Missing)",0.0388268,0.0206716,-0.0174725,0,80,unavailable,1.5,0.5,0.6,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204382,XAGE1B,admission_only,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338827,0.290672,0.222527,0,80,unavailable,1.5,0.5,0.6,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204382,XAGE1B,selectivity_revised,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338827,0.290672,0.222527,0,80,unavailable,1.5,0.5,0.6,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204382,XAGE1B,grid_revised,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338827,0.290672,0.222527,0,80,unavailable,1.5,0.5,0.6,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204382,XAGE1B,current_adaptive,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338827,0.290672,0.222527,0,80,unavailable,1.5,0.5,0.6,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204382,XAGE1B,current_fixed,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.4899% (minimum 99%, Missing); basal ganglia: 95.0464% (minimum 99%, Missing); cerebral cortex: 94.8995% (minimum 95%, Enhanced); hippocampal formation: 96.0876% (minimum 99%, Missing); hypothalamus: 96.2382% (minimum 99%, Missing); midbrain: 95.7878% (minimum 99%, Missing); pituitary gland: 97.3059% (minimum 99%, Missing); skeletal muscle: 94.1718% (minimum 95%, Enhanced); spinal cord: 95.3416% (minimum 99%, Missing)",0.05,0.028374,-0.0395356,0,4,partial,3.8,1.7,2.4,"basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204390,HSPA1L,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.298374,0.200464,0,4,partial,3.8,1.7,2.4,"basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204390,HSPA1L,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.298374,0.200464,0,4,partial,3.8,1.7,2.4,"basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204390,HSPA1L,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.298374,0.200464,0,4,partial,3.8,1.7,2.4,"basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204390,HSPA1L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.312382,0.273059,0.191718,0,4,partial,3.8,1.7,2.4,"skeletal muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204390,HSPA1L,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0486254,0.03,0.0045243,0,3,partial,0.8,0.3,0.2,,pituitary gland / cells in anterior : High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204414,CSHL1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics"
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.348625,0.3,0.244524,0,3,partial,0.8,0.3,0.2,,pituitary gland / cells in anterior : High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204414,CSHL1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics"
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.348625,0.3,0.244524,0,3,partial,0.8,0.3,0.2,,pituitary gland / cells in anterior : High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204414,CSHL1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics"
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.348625,0.3,0.244524,0,3,partial,0.8,0.3,0.2,,pituitary gland / cells in anterior : High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204414,CSHL1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics"
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.348625,0.29794,0.244524,0,3,partial,0.8,0.3,0.2,,pituitary gland / cells in anterior : High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204414,CSHL1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics"
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204449,TRIM49C,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204449,TRIM49C,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204449,TRIM49C,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204449,TRIM49C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204449,TRIM49C,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204478,PRAMEF20,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204478,PRAMEF20,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204478,PRAMEF20,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204478,PRAMEF20,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204478,PRAMEF20,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204480,PRAMEF19,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204480,PRAMEF19,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204480,PRAMEF19,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204480,PRAMEF19,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204480,PRAMEF19,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204481,PRAMEF14,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204481,PRAMEF14,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204481,PRAMEF14,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204481,PRAMEF14,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204481,PRAMEF14,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204501,PRAMEF15,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204501,PRAMEF15,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204501,PRAMEF15,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204501,PRAMEF15,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204501,PRAMEF15,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); bone marrow: 80.0000% (minimum 99%, Missing); cerebral cortex: 80.0000% (minimum 99%, Missing); duodenum: 80.0000% (minimum 99%, Missing); esophagus: 44.4444% (minimum 97%, Missing); heart muscle: 40.0000% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); pancreas: 80.0000% (minimum 99%, Missing); retina: 57.1429% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 1.2308% (minimum 99%, Missing); skin: 57.1429% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); urinary bladder: 80.0000% (minimum 97%, Missing)",-0.378571,-0.525556,-0.977692,0,80,unavailable,32.1,0.5,0.3,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204505,PRAMEF9,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 44.4444% (minimum 70%, Missing); heart muscle: 40.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); skeletal muscle: 1.2308% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.255556,-0.737692,0,80,unavailable,32.1,0.5,0.3,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204505,PRAMEF9,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 44.4444% (minimum 70%, Missing); heart muscle: 40.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); skeletal muscle: 1.2308% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.255556,-0.737692,0,80,unavailable,32.1,0.5,0.3,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204505,PRAMEF9,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 44.4444% (minimum 70%, Missing); heart muscle: 40.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); skeletal muscle: 1.2308% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.255556,-0.737692,0,80,unavailable,32.1,0.5,0.3,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204505,PRAMEF9,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 44.4444% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 40.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 57.1429% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 1.2308% (minimum 75%, Baseline (adaptation disabled)); skin: 57.1429% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 65%, Baseline (adaptation disabled))",-0.0785714,-0.255556,-0.737692,0,80,unavailable,32.1,0.5,0.3,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204505,PRAMEF9,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.3333% (minimum 95%, Uncertain); adrenal gland: 52.5000% (minimum 99%, Missing); amygdala: 84.0000% (minimum 99%, Missing); basal ganglia: 80.7692% (minimum 99%, Missing); bone marrow: 24.1379% (minimum 99%, Missing); cerebellum: 77.7778% (minimum 99%, Missing); cerebral cortex: 65.6250% (minimum 99%, Missing); choroid plexus: 60.0000% (minimum 99%, Missing); colon: 63.6364% (minimum 97%, Missing); duodenum: 67.7419% (minimum 99%, Missing); esophagus: 65.6250% (minimum 97%, Missing); heart muscle: 58.3333% (minimum 99%, Missing); hippocampal formation: 84.0000% (minimum 99%, Missing); hypothalamus: 84.0000% (minimum 99%, Missing); kidney: 61.7647% (minimum 99%, Missing); liver: 52.5000% (minimum 99%, Missing); lung: 58.3333% (minimum 99%, Missing); lymph node: 58.3333% (minimum 97%, Missing); midbrain: 80.7692% (minimum 99%, Missing); pancreas: 61.7647% (minimum 99%, Missing); parathyroid gland: 50.0000% (minimum 97%, Missing); pituitary gland: 61.7647% (minimum 99%, Missing); rectum: 58.3333% (minimum 97%, Missing); retina: 44.6809% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 97%, Missing); skeletal muscle: 55.2632% (minimum 99%, Missing); skin: 52.5000% (minimum 95%, Missing); small intestine: 65.6250% (minimum 99%, Missing); smooth muscle: 55.2632% (minimum 99%, Missing); spinal cord: 77.7778% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 58.3333% (minimum 97%, Missing); thymus: 56.7568% (minimum 95%, Missing); thyroid gland: 56.7568% (minimum 95%, Missing); tongue: 51.2195% (minimum 97%, Missing); urinary bladder: 61.7647% (minimum 97%, Missing)",-0.45,-0.47,-0.748621,0,7,partial,6.6,2.1,2.1,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204524,ZNF805,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.3333% (minimum 65%, Uncertain); adrenal gland: 52.5000% (minimum 75%, Missing); bone marrow: 24.1379% (minimum 75%, Missing); cerebral cortex: 65.6250% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 67.7419% (minimum 75%, Missing); esophagus: 65.6250% (minimum 70%, Missing); heart muscle: 58.3333% (minimum 75%, Missing); kidney: 61.7647% (minimum 75%, Missing); liver: 52.5000% (minimum 75%, Missing); lung: 58.3333% (minimum 75%, Missing); lymph node: 58.3333% (minimum 70%, Missing); pancreas: 61.7647% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 61.7647% (minimum 75%, Missing); rectum: 58.3333% (minimum 70%, Missing); retina: 44.6809% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 55.2632% (minimum 75%, Missing); skin: 52.5000% (minimum 65%, Missing); small intestine: 65.6250% (minimum 75%, Missing); smooth muscle: 55.2632% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 58.3333% (minimum 70%, Missing); thymus: 56.7568% (minimum 65%, Missing); thyroid gland: 56.7568% (minimum 65%, Missing); tongue: 51.2195% (minimum 70%, Missing); urinary bladder: 61.7647% (minimum 70%, Missing)",-0.15,-0.2,-0.508621,0,7,partial,6.6,2.1,2.1,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204524,ZNF805,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.3333% (minimum 65%, Uncertain); adrenal gland: 52.5000% (minimum 75%, Missing); bone marrow: 24.1379% (minimum 75%, Missing); cerebral cortex: 65.6250% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 67.7419% (minimum 75%, Missing); esophagus: 65.6250% (minimum 70%, Missing); heart muscle: 58.3333% (minimum 75%, Missing); kidney: 61.7647% (minimum 75%, Missing); liver: 52.5000% (minimum 75%, Missing); lung: 58.3333% (minimum 75%, Missing); lymph node: 58.3333% (minimum 70%, Missing); pancreas: 61.7647% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 61.7647% (minimum 75%, Missing); rectum: 58.3333% (minimum 70%, Missing); retina: 44.6809% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 55.2632% (minimum 75%, Missing); skin: 52.5000% (minimum 65%, Missing); small intestine: 65.6250% (minimum 75%, Missing); smooth muscle: 55.2632% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 58.3333% (minimum 70%, Missing); thymus: 56.7568% (minimum 65%, Missing); thyroid gland: 56.7568% (minimum 65%, Missing); tongue: 51.2195% (minimum 70%, Missing); urinary bladder: 61.7647% (minimum 70%, Missing)",-0.15,-0.2,-0.508621,0,7,partial,6.6,2.1,2.1,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204524,ZNF805,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.3333% (minimum 65%, Uncertain); adrenal gland: 52.5000% (minimum 75%, Missing); bone marrow: 24.1379% (minimum 75%, Missing); cerebral cortex: 65.6250% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 67.7419% (minimum 75%, Missing); esophagus: 65.6250% (minimum 70%, Missing); heart muscle: 58.3333% (minimum 75%, Missing); kidney: 61.7647% (minimum 75%, Missing); liver: 52.5000% (minimum 75%, Missing); lung: 58.3333% (minimum 75%, Missing); lymph node: 58.3333% (minimum 70%, Missing); pancreas: 61.7647% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 61.7647% (minimum 75%, Missing); rectum: 58.3333% (minimum 70%, Missing); retina: 44.6809% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 55.2632% (minimum 75%, Missing); skin: 52.5000% (minimum 65%, Missing); small intestine: 65.6250% (minimum 75%, Missing); smooth muscle: 55.2632% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 58.3333% (minimum 70%, Missing); thymus: 56.7568% (minimum 65%, Missing); thyroid gland: 56.7568% (minimum 65%, Missing); tongue: 51.2195% (minimum 70%, Missing); urinary bladder: 61.7647% (minimum 70%, Missing)",-0.15,-0.2,-0.508621,0,7,partial,6.6,2.1,2.1,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204524,ZNF805,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.3333% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 52.5000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 24.1379% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 65.6250% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 63.6364% (minimum 70%, Baseline (adaptation disabled)); duodenum: 67.7419% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.6250% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 58.3333% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.7647% (minimum 75%, Baseline (adaptation disabled)); liver: 52.5000% (minimum 75%, Baseline (adaptation disabled)); lung: 58.3333% (minimum 75%, Baseline (adaptation disabled)); lymph node: 58.3333% (minimum 70%, Baseline (adaptation disabled)); pancreas: 61.7647% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.0000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 61.7647% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.3333% (minimum 70%, Baseline (adaptation disabled)); retina: 44.6809% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.2632% (minimum 75%, Baseline (adaptation disabled)); skin: 52.5000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 65.6250% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.2632% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 58.3333% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.7568% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.7568% (minimum 65%, Baseline (adaptation disabled)); tongue: 51.2195% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.7647% (minimum 70%, Baseline (adaptation disabled))",-0.15,-0.2,-0.508621,0,7,partial,6.6,2.1,2.1,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204524,ZNF805,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.0441% (minimum 95%, Missing); adrenal gland: 94.8736% (minimum 99%, Missing); amygdala: 93.5596% (minimum 99%, Missing); basal ganglia: 92.7885% (minimum 99%, Missing); cerebellum: 88.9401% (minimum 99%, Missing); cerebral cortex: 92.9800% (minimum 99%, Missing); colon: 89.5889% (minimum 97%, Missing); duodenum: 93.3656% (minimum 99%, Missing); esophagus: 90.1869% (minimum 97%, Missing); heart muscle: 92.2814% (minimum 99%, Missing); hippocampal formation: 93.9499% (minimum 99%, Missing); hypothalamus: 93.3656% (minimum 99%, Missing); kidney: 87.6135% (minimum 99%, Missing); liver: 91.9048% (minimum 99%, Missing); lung: 93.9499% (minimum 99%, Missing); lymph node: 95.2079% (minimum 97%, Missing); midbrain: 94.2777% (minimum 99%, Missing); pancreas: 90.5496% (minimum 99%, Missing); pituitary gland: 93.7543% (minimum 99%, Missing); salivary gland: 92.4077% (minimum 97%, Missing); skeletal muscle: 87.8985% (minimum 99%, Missing); skin: 88.8816% (minimum 95%, Missing); small intestine: 90.4284% (minimum 99%, Missing); smooth muscle: 98.9019% (minimum 99%, Missing); spinal cord: 94.9403% (minimum 99%, Missing); spleen: 91.2221% (minimum 95%, Missing); stomach: 90.9152% (minimum 97%, Missing); thyroid gland: 89.6483% (minimum 95%, Missing); urinary bladder: 91.2838% (minimum 97%, Missing)",-0.0611842,-0.0741114,-0.113865,0,80,unavailable,19.1,15.7,16.9,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 2); thyroid gland: 15.6 nTPM (manageable, limit 5); esophagus: 14.7 nTPM (protected, limit 2); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); urinary bladder: 12.9 nTPM (protected, limit 2); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); salivary gland: 11.1 nTPM (protected, limit 2); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); hypothalamus: 9.6 nTPM (vital, limit 1); duodenum: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204536,CCHCR1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.238816,0.195889,0.126135,0,80,unavailable,19.1,15.7,16.9,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 2); thyroid gland: 15.6 nTPM (manageable, limit 5); esophagus: 14.7 nTPM (protected, limit 2); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); urinary bladder: 12.9 nTPM (protected, limit 2); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); salivary gland: 11.1 nTPM (protected, limit 2); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); hypothalamus: 9.6 nTPM (vital, limit 1); duodenum: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204536,CCHCR1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.238816,0.195889,0.126135,0,80,unavailable,19.1,15.7,16.9,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 3); thyroid gland: 15.6 nTPM (manageable, limit 5); esophagus: 14.7 nTPM (protected, limit 3); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); urinary bladder: 12.9 nTPM (protected, limit 3); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); salivary gland: 11.1 nTPM (protected, limit 3); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); hypothalamus: 9.6 nTPM (vital, limit 1); duodenum: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204536,CCHCR1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.238816,0.195889,0.126135,0,80,unavailable,19.1,15.7,16.9,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 3); thyroid gland: 15.6 nTPM (manageable, limit 5); esophagus: 14.7 nTPM (protected, limit 3); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); urinary bladder: 12.9 nTPM (protected, limit 3); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); salivary gland: 11.1 nTPM (protected, limit 3); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); hypothalamus: 9.6 nTPM (vital, limit 1); duodenum: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204536,CCHCR1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.238816,0.195889,0.126135,0,80,unavailable,19.1,15.7,16.9,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 3); thyroid gland: 15.6 nTPM (manageable, limit 5); esophagus: 14.7 nTPM (protected, limit 3); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); urinary bladder: 12.9 nTPM (protected, limit 3); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); salivary gland: 11.1 nTPM (protected, limit 3); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); hypothalamus: 9.6 nTPM (vital, limit 1); duodenum: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204536,CCHCR1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8889% (minimum 99%, Missing); cerebral cortex: 98.9805% (minimum 99%, Missing); lung: 98.4332% (minimum 99%, Missing); small intestine: 98.3425% (minimum 99%, Missing)",0.0209091,0.0161496,-0.00657459,0,80,unavailable,1.8,1.5,3.2,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204540,PSORS1C1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.320909,0.28615,0.233425,0,80,unavailable,1.8,1.5,3.2,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204540,PSORS1C1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.320909,0.28615,0.233425,0,80,unavailable,1.8,1.5,3.2,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204540,PSORS1C1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.320909,0.28615,0.233425,0,80,unavailable,1.8,1.5,3.2,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204540,PSORS1C1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.320909,0.28615,0.233425,0,80,unavailable,1.8,1.5,3.2,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204540,PSORS1C1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204548,DEFB121,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204548,DEFB121,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204548,DEFB121,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204548,DEFB121,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204548,DEFB121,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 41.1765% (minimum 97%, Missing); kidney: 87.5000% (minimum 99%, Missing); liver: 48.2759% (minimum 99%, Missing); small intestine: 32.5581% (minimum 99%, Missing); stomach: 93.3333% (minimum 97%, Missing)",0.05,-0.558235,-0.664419,0,80,unavailable,2.9,2,0,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204614,TRIM40,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 41.1765% (minimum 70%, Missing); liver: 48.2759% (minimum 75%, Missing); small intestine: 32.5581% (minimum 75%, Missing)",0.35,-0.288235,-0.424419,0,80,unavailable,2.9,2,0,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204614,TRIM40,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 41.1765% (minimum 70%, Missing); liver: 48.2759% (minimum 75%, Missing); small intestine: 32.5581% (minimum 75%, Missing)",0.35,-0.288235,-0.424419,0,80,unavailable,2.9,2,0,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204614,TRIM40,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 41.1765% (minimum 70%, Missing); liver: 48.2759% (minimum 75%, Missing); small intestine: 32.5581% (minimum 75%, Missing)",0.35,-0.288235,-0.424419,0,80,unavailable,2.9,2,0,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204614,TRIM40,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 41.1765% (minimum 70%, Baseline (adaptation disabled)); liver: 48.2759% (minimum 75%, Baseline (adaptation disabled)); small intestine: 32.5581% (minimum 75%, Baseline (adaptation disabled))",0.35,-0.288235,-0.424419,0,80,unavailable,2.9,2,0,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204614,TRIM40,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"hypothalamus: 27.2727% (minimum 99%, Missing); spinal cord: 42.8571% (minimum 99%, Missing); tongue: 75.0000% (minimum 97%, Missing)",0.05,-0.22,-0.717273,0,80,unavailable,0.8,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204640,NMS,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"hypothalamus: 27.2727% (minimum 75%, Missing); spinal cord: 42.8571% (minimum 75%, Missing)",0.35,0.05,-0.477273,0,80,unavailable,0.8,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204640,NMS,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"hypothalamus: 27.2727% (minimum 75%, Missing); spinal cord: 42.8571% (minimum 75%, Missing)",0.35,0.05,-0.477273,0,80,unavailable,0.8,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204640,NMS,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"hypothalamus: 27.2727% (minimum 75%, Missing); spinal cord: 42.8571% (minimum 75%, Missing)",0.35,0.05,-0.477273,0,80,unavailable,0.8,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204640,NMS,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"hypothalamus: 27.2727% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 42.8571% (minimum 75%, Baseline (adaptation disabled))",0.35,0.05,-0.477273,0,80,unavailable,0.8,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204640,NMS,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.4026% (minimum 99%, Missing); amygdala: 90.3614% (minimum 99%, Missing); basal ganglia: 90.9091% (minimum 99%, Missing); cerebellum: 93.1677% (minimum 99%, Missing); cerebral cortex: 93.7500% (minimum 99%, Missing); colon: 96.1538% (minimum 97%, Missing); heart muscle: 97.4026% (minimum 99%, Missing); hippocampal formation: 90.3614% (minimum 99%, Missing); hypothalamus: 89.8204% (minimum 99%, Missing); kidney: 98.0392% (minimum 99%, Missing); liver: 98.6842% (minimum 99%, Missing); lung: 98.6842% (minimum 99%, Missing); midbrain: 84.2697% (minimum 99%, Missing); pancreas: 94.3396% (minimum 99%, Missing); pituitary gland: 94.3396% (minimum 99%, Missing); retina: 97.4026% (minimum 99%, Missing); salivary gland: 96.7742% (minimum 97%, Missing); skeletal muscle: 97.4026% (minimum 99%, Missing); small intestine: 96.7742% (minimum 99%, Missing); spinal cord: 83.3333% (minimum 99%, Missing)",0.0115385,-0.00846154,-0.156667,0,80,unavailable,3,0.6,0.6,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204659,CBY3,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.311538,0.261538,0.0833333,0,80,unavailable,3,0.6,0.6,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204659,CBY3,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.311538,0.261538,0.0833333,0,80,unavailable,3,0.6,0.6,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204659,CBY3,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.311538,0.261538,0.0833333,0,80,unavailable,3,0.6,0.6,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204659,CBY3,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.311538,0.261538,0.0833333,0,80,unavailable,3,0.6,0.6,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204659,CBY3,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204661,SPATA31J1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204661,SPATA31J1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204661,SPATA31J1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204661,SPATA31J1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204661,SPATA31J1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.0021875,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204669,C9orf57,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242188,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204669,C9orf57,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242188,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204669,C9orf57,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242188,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204669,C9orf57,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242188,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204669,C9orf57,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204671,IL31,admission_only,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204671,IL31,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204671,IL31,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204671,IL31,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204671,IL31,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204688,OR2H1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204688,OR2H1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204688,OR2H1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204688,OR2H1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204688,OR2H1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204694,OR11A1,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204694,OR11A1,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204694,OR11A1,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204694,OR11A1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204694,OR11A1,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); bone marrow: 40.0000% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 85.7143% (minimum 97%, Missing); heart muscle: 85.7143% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 54.5455% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); pancreas: 85.7143% (minimum 99%, Missing); rectum: 85.7143% (minimum 97%, Missing); retina: 25.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 60.0000% (minimum 99%, Missing); skin: 46.1538% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 85.7143% (minimum 99%, Missing); spleen: 60.0000% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Missing); thymus: 85.7143% (minimum 95%, Missing); thyroid gland: 75.0000% (minimum 95%, Missing); urinary bladder: 85.7143% (minimum 97%, Missing)",-0.488462,-0.303333,-0.74,0,80,unavailable,1.8,0.3,0.7,"retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204695,OR14J1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); bone marrow: 40.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 54.5455% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); retina: 25.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); skin: 46.1538% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.188462,-0.0333333,-0.5,0,80,unavailable,1.8,0.3,0.7,"retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204695,OR14J1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); bone marrow: 40.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 54.5455% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); retina: 25.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); skin: 46.1538% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.188462,-0.0333333,-0.5,0,80,unavailable,1.8,0.3,0.7,"retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204695,OR14J1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); bone marrow: 40.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 54.5455% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); retina: 25.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); skin: 46.1538% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.188462,-0.0333333,-0.5,0,80,unavailable,1.8,0.3,0.7,"retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204695,OR14J1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 40.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 54.5455% (minimum 75%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); retina: 25.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 46.1538% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 70%, Baseline (adaptation disabled))",-0.188462,-0.0333333,-0.5,0,80,unavailable,1.8,0.3,0.7,"retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204695,OR14J1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing)",-0.15,0.03,-0.323333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204700,OR2J2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.3,-0.0833333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204700,OR2J2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.3,-0.0833333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204700,OR2J2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.3,-0.0833333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204700,OR2J2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.15,0.3,-0.0833333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204700,OR2J2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 75.0000% (minimum 99%, Missing)",0.05,0.03,-0.24,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204701,OR2J3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 75.0000% (minimum 75%, Missing)",0.35,0.3,-1.11022e-16,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204701,OR2J3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 75.0000% (minimum 75%, Missing)",0.35,0.3,-1.11022e-16,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204701,OR2J3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 75.0000% (minimum 75%, Missing)",0.35,0.3,-1.11022e-16,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204701,OR2J3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 75.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-1.11022e-16,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204701,OR2J3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204704,OR2W1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204704,OR2W1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204704,OR2W1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204704,OR2W1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204704,OR2W1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.6667% (minimum 95%, Missing); adrenal gland: 65.0000% (minimum 99%, Missing); amygdala: 92.8571% (minimum 99%, Missing); basal ganglia: 92.8571% (minimum 99%, Missing); bone marrow: 92.8571% (minimum 99%, Missing); cerebellum: 81.2500% (minimum 99%, Missing); cerebral cortex: 76.4706% (minimum 99%, Missing); choroid plexus: 76.4706% (minimum 99%, Missing); colon: 86.6667% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); heart muscle: 86.6667% (minimum 99%, Missing); hippocampal formation: 92.8571% (minimum 99%, Missing); hypothalamus: 86.6667% (minimum 99%, Missing); kidney: 76.4706% (minimum 99%, Missing); liver: 81.2500% (minimum 99%, Missing); lung: 65.0000% (minimum 99%, Missing); lymph node: 81.2500% (minimum 97%, Missing); midbrain: 92.8571% (minimum 99%, Missing); pancreas: 50.0000% (minimum 99%, Missing); parathyroid gland: 61.9048% (minimum 97%, Missing); pituitary gland: 76.4706% (minimum 99%, Missing); rectum: 76.4706% (minimum 97%, Missing); retina: 61.9048% (minimum 99%, Missing); salivary gland: 61.9048% (minimum 97%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 81.2500% (minimum 99%, Missing); smooth muscle: 81.2500% (minimum 99%, Missing); spinal cord: 81.2500% (minimum 99%, Missing); stomach: 81.2500% (minimum 97%, Missing); thymus: 86.6667% (minimum 95%, Missing); thyroid gland: 56.5217% (minimum 95%, Missing); urinary bladder: 92.8571% (minimum 97%, Missing)",-0.384783,-0.350952,-0.49,0,80,unavailable,1.3,0.8,1,"pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204764,RANBP17,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.0000% (minimum 75%, Missing); lung: 65.0000% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); parathyroid gland: 61.9048% (minimum 70%, Missing); retina: 61.9048% (minimum 75%, Missing); salivary gland: 61.9048% (minimum 70%, Missing); thyroid gland: 56.5217% (minimum 65%, Missing)",-0.0847826,-0.0809524,-0.25,0,80,unavailable,1.3,0.8,1,"pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204764,RANBP17,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.0000% (minimum 75%, Missing); lung: 65.0000% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); parathyroid gland: 61.9048% (minimum 70%, Missing); retina: 61.9048% (minimum 75%, Missing); salivary gland: 61.9048% (minimum 70%, Missing); thyroid gland: 56.5217% (minimum 65%, Missing)",-0.0847826,-0.0809524,-0.25,0,80,unavailable,1.3,0.8,1,"pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204764,RANBP17,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.0000% (minimum 75%, Missing); lung: 65.0000% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); parathyroid gland: 61.9048% (minimum 70%, Missing); retina: 61.9048% (minimum 75%, Missing); salivary gland: 61.9048% (minimum 70%, Missing); thyroid gland: 56.5217% (minimum 65%, Missing)",-0.0847826,-0.0809524,-0.25,0,80,unavailable,1.3,0.8,1,"pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204764,RANBP17,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 65.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 50.0000% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.9048% (minimum 70%, Baseline (adaptation disabled)); retina: 61.9048% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.9048% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 56.5217% (minimum 65%, Baseline (adaptation disabled))",-0.0847826,-0.0809524,-0.25,0,80,unavailable,1.3,0.8,1,"pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204764,RANBP17,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204849,SPATA31A1,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204849,SPATA31A1,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204849,SPATA31A1,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204849,SPATA31A1,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204849,SPATA31A1,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 60%, Enhanced); pituitary gland: 96.2963% (minimum 99%, Missing); skin: 2.3339% (minimum 95%, Missing)",-0.926661,0.03,-0.027037,0,4,partial,0.1,0.2,108.8,"skin: 108.8 nTPM (manageable, limit 5)",,71,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204897,KRT25,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 2.3339% (minimum 65%, Missing)",-0.626661,0.3,0.212963,0,4,partial,0.1,0.2,108.8,"skin: 108.8 nTPM (manageable, limit 5)",,71,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204897,KRT25,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 2.3339% (minimum 65%, Missing)",-0.626661,0.3,0.212963,0,4,partial,0.1,0.2,108.8,"skin: 108.8 nTPM (manageable, limit 5)",,71,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204897,KRT25,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 2.3339% (minimum 65%, Missing)",-0.626661,0.3,0.212963,0,4,partial,0.1,0.2,108.8,"skin: 108.8 nTPM (manageable, limit 5)",,71,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204897,KRT25,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Baseline (adaptation disabled)); skin: 2.3339% (minimum 65%, Baseline (adaptation disabled))",-0.626661,0.228571,0.212963,0,4,partial,0.1,0.2,108.8,"skin: 108.8 nTPM (manageable, limit 5)",,71,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204897,KRT25,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204918,PRR20B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204918,PRR20B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204918,PRR20B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204918,PRR20B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204918,PRR20B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204919,PRR20A,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204919,PRR20A,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204919,PRR20A,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204919,PRR20A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000204919,PRR20A,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.9583% (minimum 99%, Missing); basal ganglia: 98.9583% (minimum 99%, Missing); bone marrow: 77.2358% (minimum 95%, Enhanced); choroid plexus: 98.9583% (minimum 99%, Missing); hippocampal formation: 98.9583% (minimum 99%, Missing); hypothalamus: 98.9583% (minimum 99%, Missing); lung: 98.9583% (minimum 99%, Missing); lymph node: 95.0000% (minimum 97%, Missing); retina: 95.0000% (minimum 99%, Missing); spinal cord: 97.9381% (minimum 99%, Missing); stomach: 96.9388% (minimum 97%, Missing)",0.0193878,-0.02,-0.177642,0,5,partial,2.8,0.5,0.3,,kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204930,FAM221B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.319388,0.25,0.172358,0,5,partial,2.8,0.5,0.3,,kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204930,FAM221B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.319388,0.25,0.172358,0,5,partial,2.8,0.5,0.3,,kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204930,FAM221B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.319388,0.25,0.172358,0,5,partial,2.8,0.5,0.3,,kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204930,FAM221B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.319388,0.25,0.0223577,0,5,partial,2.8,0.5,0.3,"bone marrow: 2.8 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204930,FAM221B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00724518,0,2,partial,0.8,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204941,PSG5,admission_only,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.247245,0,2,partial,0.8,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204941,PSG5,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.247245,0,2,partial,0.8,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204941,PSG5,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.247245,0,2,partial,0.8,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204941,PSG5,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.345417,0.297245,0.242687,0,2,partial,0.8,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204941,PSG5,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 82.0513% (minimum 95%, Missing); adrenal gland: 72.7273% (minimum 99%, Missing); amygdala: 56.1404% (minimum 99%, Missing); basal ganglia: 54.2373% (minimum 99%, Missing); bone marrow: 84.2105% (minimum 99%, Missing); cerebellum: 48.4848% (minimum 99%, Missing); cerebral cortex: 48.4848% (minimum 99%, Missing); choroid plexus: 68.0851% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 78.0488% (minimum 99%, Missing); esophagus: 60.3774% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 58.1818% (minimum 99%, Missing); hypothalamus: 58.1818% (minimum 99%, Missing); kidney: 59.2593% (minimum 99%, Missing); liver: 76.1905% (minimum 99%, Missing); lung: 76.1905% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 61.5385% (minimum 99%, Missing); pancreas: 69.5652% (minimum 99%, Missing); parathyroid gland: 58.1818% (minimum 97%, Missing); pituitary gland: 69.5652% (minimum 99%, Missing); rectum: 82.0513% (minimum 97%, Missing); retina: 71.1111% (minimum 99%, Missing); salivary gland: 65.3061% (minimum 97%, Missing); skeletal muscle: 47.0588% (minimum 99%, Missing); skin: 57.1429% (minimum 95%, Missing); small intestine: 78.0488% (minimum 99%, Missing); smooth muscle: 65.3061% (minimum 99%, Missing); spinal cord: 62.7451% (minimum 99%, Missing); spleen: 78.0488% (minimum 95%, Missing); stomach: 68.0851% (minimum 97%, Missing); thymus: 68.0851% (minimum 95%, Missing); thyroid gland: 62.7451% (minimum 95%, Missing); tongue: 64.0000% (minimum 97%, Missing); urinary bladder: 64.0000% (minimum 97%, Missing)",-0.378571,-0.388182,-0.519412,0,80,unavailable,3.6,2.3,2.4,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204947,ZNF425,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.7273% (minimum 75%, Missing); amygdala: 56.1404% (minimum 75%, Missing); basal ganglia: 54.2373% (minimum 75%, Missing); cerebellum: 48.4848% (minimum 75%, Missing); cerebral cortex: 48.4848% (minimum 75%, Missing); choroid plexus: 68.0851% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); esophagus: 60.3774% (minimum 70%, Missing); hippocampal formation: 58.1818% (minimum 75%, Missing); hypothalamus: 58.1818% (minimum 75%, Missing); kidney: 59.2593% (minimum 75%, Missing); midbrain: 61.5385% (minimum 75%, Missing); pancreas: 69.5652% (minimum 75%, Missing); parathyroid gland: 58.1818% (minimum 70%, Missing); pituitary gland: 69.5652% (minimum 75%, Missing); retina: 71.1111% (minimum 75%, Missing); salivary gland: 65.3061% (minimum 70%, Missing); skeletal muscle: 47.0588% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); smooth muscle: 65.3061% (minimum 75%, Missing); spinal cord: 62.7451% (minimum 75%, Missing); stomach: 68.0851% (minimum 70%, Missing); thyroid gland: 62.7451% (minimum 65%, Missing); tongue: 64.0000% (minimum 70%, Missing); urinary bladder: 64.0000% (minimum 70%, Missing)",-0.0785714,-0.118182,-0.279412,0,80,unavailable,3.6,2.3,2.4,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204947,ZNF425,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.7273% (minimum 75%, Missing); amygdala: 56.1404% (minimum 75%, Missing); basal ganglia: 54.2373% (minimum 75%, Missing); cerebellum: 48.4848% (minimum 75%, Missing); cerebral cortex: 48.4848% (minimum 75%, Missing); choroid plexus: 68.0851% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); esophagus: 60.3774% (minimum 70%, Missing); hippocampal formation: 58.1818% (minimum 75%, Missing); hypothalamus: 58.1818% (minimum 75%, Missing); kidney: 59.2593% (minimum 75%, Missing); midbrain: 61.5385% (minimum 75%, Missing); pancreas: 69.5652% (minimum 75%, Missing); parathyroid gland: 58.1818% (minimum 70%, Missing); pituitary gland: 69.5652% (minimum 75%, Missing); retina: 71.1111% (minimum 75%, Missing); salivary gland: 65.3061% (minimum 70%, Missing); skeletal muscle: 47.0588% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); smooth muscle: 65.3061% (minimum 75%, Missing); spinal cord: 62.7451% (minimum 75%, Missing); stomach: 68.0851% (minimum 70%, Missing); thyroid gland: 62.7451% (minimum 65%, Missing); tongue: 64.0000% (minimum 70%, Missing); urinary bladder: 64.0000% (minimum 70%, Missing)",-0.0785714,-0.118182,-0.279412,0,80,unavailable,3.6,2.3,2.4,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204947,ZNF425,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.7273% (minimum 75%, Missing); amygdala: 56.1404% (minimum 75%, Missing); basal ganglia: 54.2373% (minimum 75%, Missing); cerebellum: 48.4848% (minimum 75%, Missing); cerebral cortex: 48.4848% (minimum 75%, Missing); choroid plexus: 68.0851% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); esophagus: 60.3774% (minimum 70%, Missing); hippocampal formation: 58.1818% (minimum 75%, Missing); hypothalamus: 58.1818% (minimum 75%, Missing); kidney: 59.2593% (minimum 75%, Missing); midbrain: 61.5385% (minimum 75%, Missing); pancreas: 69.5652% (minimum 75%, Missing); parathyroid gland: 58.1818% (minimum 70%, Missing); pituitary gland: 69.5652% (minimum 75%, Missing); retina: 71.1111% (minimum 75%, Missing); salivary gland: 65.3061% (minimum 70%, Missing); skeletal muscle: 47.0588% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); smooth muscle: 65.3061% (minimum 75%, Missing); spinal cord: 62.7451% (minimum 75%, Missing); stomach: 68.0851% (minimum 70%, Missing); thyroid gland: 62.7451% (minimum 65%, Missing); tongue: 64.0000% (minimum 70%, Missing); urinary bladder: 64.0000% (minimum 70%, Missing)",-0.0785714,-0.118182,-0.279412,0,80,unavailable,3.6,2.3,2.4,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204947,ZNF425,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.7273% (minimum 75%, Baseline (adaptation disabled)); amygdala: 56.1404% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.2373% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 48.4848% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.4848% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.0851% (minimum 75%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 70%, Baseline (adaptation disabled)); esophagus: 60.3774% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 58.1818% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.1818% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.2593% (minimum 75%, Baseline (adaptation disabled)); midbrain: 61.5385% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.5652% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.1818% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.5652% (minimum 75%, Baseline (adaptation disabled)); retina: 71.1111% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 65.3061% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 47.0588% (minimum 75%, Baseline (adaptation disabled)); skin: 57.1429% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 65.3061% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.7451% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.0851% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 62.7451% (minimum 65%, Baseline (adaptation disabled)); tongue: 64.0000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 64.0000% (minimum 70%, Baseline (adaptation disabled))",-0.0785714,-0.118182,-0.279412,0,80,unavailable,3.6,2.3,2.4,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204947,ZNF425,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204952,FBXO47,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204952,FBXO47,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204952,FBXO47,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204952,FBXO47,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204952,FBXO47,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Missing); adrenal gland: 76.9231% (minimum 99%, Missing); amygdala: 58.8235% (minimum 99%, Missing); basal ganglia: 40.0000% (minimum 99%, Missing); bone marrow: 90.9091% (minimum 99%, Missing); cerebellum: 43.4783% (minimum 99%, Missing); cerebral cortex: 35.7143% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 90.9091% (minimum 99%, Missing); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 45.4545% (minimum 99%, Missing); hippocampal formation: 55.5556% (minimum 99%, Missing); hypothalamus: 62.5000% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); lung: 76.9231% (minimum 99%, Missing); lymph node: 90.9091% (minimum 97%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); rectum: 90.9091% (minimum 97%, Missing); retina: 47.6190% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 62.5000% (minimum 99%, Missing); skin: 76.9231% (minimum 95%, Missing); small intestine: 90.9091% (minimum 99%, Missing); smooth muscle: 71.4286% (minimum 99%, Missing); spinal cord: 71.4286% (minimum 99%, Missing); spleen: 90.9091% (minimum 95%, Missing); stomach: 90.9091% (minimum 97%, Missing); thymus: 90.9091% (minimum 95%, Missing); thyroid gland: 83.3333% (minimum 95%, Missing); tongue: 76.9231% (minimum 97%, Missing); urinary bladder: 71.4286% (minimum 97%, Missing)",-0.180769,-0.303333,-0.632857,0,80,unavailable,1.8,0.5,0.3,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204956,PCDHGA1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 58.8235% (minimum 75%, Missing); basal ganglia: 40.0000% (minimum 75%, Missing); cerebellum: 43.4783% (minimum 75%, Missing); cerebral cortex: 35.7143% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); heart muscle: 45.4545% (minimum 75%, Missing); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 62.5000% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 47.6190% (minimum 75%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing)",0.119231,-0.0333333,-0.392857,0,80,unavailable,1.8,0.5,0.3,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204956,PCDHGA1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 58.8235% (minimum 75%, Missing); basal ganglia: 40.0000% (minimum 75%, Missing); cerebellum: 43.4783% (minimum 75%, Missing); cerebral cortex: 35.7143% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); heart muscle: 45.4545% (minimum 75%, Missing); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 62.5000% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 47.6190% (minimum 75%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing)",0.119231,-0.0333333,-0.392857,0,80,unavailable,1.8,0.5,0.3,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204956,PCDHGA1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 58.8235% (minimum 75%, Missing); basal ganglia: 40.0000% (minimum 75%, Missing); cerebellum: 43.4783% (minimum 75%, Missing); cerebral cortex: 35.7143% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); heart muscle: 45.4545% (minimum 75%, Missing); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 62.5000% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 47.6190% (minimum 75%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing)",0.119231,-0.0333333,-0.392857,0,80,unavailable,1.8,0.5,0.3,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204956,PCDHGA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 58.8235% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 40.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.4783% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 35.7143% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 45.4545% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.5556% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.5000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 75%, Baseline (adaptation disabled)); retina: 47.6190% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 71.4286% (minimum 75%, Baseline (adaptation disabled))",0.119231,-0.0333333,-0.392857,0,80,unavailable,1.8,0.5,0.3,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204956,PCDHGA1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Missing); adrenal gland: 91.6667% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 91.6667% (minimum 99%, Missing); bone marrow: 91.6667% (minimum 99%, Missing); cerebellum: 57.8947% (minimum 99%, Missing); cerebral cortex: 73.3333% (minimum 99%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 91.6667% (minimum 99%, Missing); midbrain: 91.6667% (minimum 99%, Missing); pancreas: 61.1111% (minimum 99%, Missing); pituitary gland: 91.6667% (minimum 99%, Missing); retina: 78.5714% (minimum 99%, Missing); skin: 91.6667% (minimum 95%, Missing); spinal cord: 73.3333% (minimum 99%, Missing)",-0.0333333,0.03,-0.411053,0,80,unavailable,0.8,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204961,PCDHA9,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 57.8947% (minimum 75%, Missing); cerebral cortex: 73.3333% (minimum 75%, Missing); pancreas: 61.1111% (minimum 75%, Missing); spinal cord: 73.3333% (minimum 75%, Missing)",0.266667,0.3,-0.171053,0,80,unavailable,0.8,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204961,PCDHA9,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 57.8947% (minimum 75%, Missing); cerebral cortex: 73.3333% (minimum 75%, Missing); pancreas: 61.1111% (minimum 75%, Missing); spinal cord: 73.3333% (minimum 75%, Missing)",0.266667,0.3,-0.171053,0,80,unavailable,0.8,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204961,PCDHA9,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 57.8947% (minimum 75%, Missing); cerebral cortex: 73.3333% (minimum 75%, Missing); pancreas: 61.1111% (minimum 75%, Missing); spinal cord: 73.3333% (minimum 75%, Missing)",0.266667,0.3,-0.171053,0,80,unavailable,0.8,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204961,PCDHA9,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 57.8947% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 61.1111% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.3333% (minimum 75%, Baseline (adaptation disabled))",0.266667,0.3,-0.171053,0,80,unavailable,0.8,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204961,PCDHA9,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 75.0000% (minimum 99%, Missing); amygdala: 50.0000% (minimum 99%, Missing); basal ganglia: 60.0000% (minimum 99%, Missing); cerebellum: 14.2857% (minimum 99%, Missing); cerebral cortex: 37.5000% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 50.0000% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); midbrain: 60.0000% (minimum 99%, Missing); pancreas: 75.0000% (minimum 99%, Missing); pituitary gland: 50.0000% (minimum 99%, Missing); retina: 37.5000% (minimum 99%, Missing); spinal cord: 50.0000% (minimum 99%, Missing)",0.05,0.03,-0.847143,0,80,unavailable,1.8,0,0,"cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204962,PCDHA8,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebellum: 14.2857% (minimum 75%, Missing); cerebral cortex: 37.5000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); midbrain: 60.0000% (minimum 75%, Missing); pancreas: 75.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 37.5000% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.607143,0,80,unavailable,1.8,0,0,"cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204962,PCDHA8,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebellum: 14.2857% (minimum 75%, Missing); cerebral cortex: 37.5000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); midbrain: 60.0000% (minimum 75%, Missing); pancreas: 75.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 37.5000% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.607143,0,80,unavailable,1.8,0,0,"cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204962,PCDHA8,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebellum: 14.2857% (minimum 75%, Missing); cerebral cortex: 37.5000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); midbrain: 60.0000% (minimum 75%, Missing); pancreas: 75.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 37.5000% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.607143,0,80,unavailable,1.8,0,0,"cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204962,PCDHA8,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 50.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 14.2857% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 37.5000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 50.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 60.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 37.5000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.607143,0,80,unavailable,1.8,0,0,"cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204962,PCDHA8,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 88.8889% (minimum 99%, Missing); amygdala: 72.7273% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); cerebellum: 32.0000% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); duodenum: 88.8889% (minimum 99%, Missing); hippocampal formation: 61.5385% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 72.7273% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); midbrain: 61.5385% (minimum 99%, Missing); pancreas: 72.7273% (minimum 99%, Missing); parathyroid gland: 88.8889% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); small intestine: 88.8889% (minimum 99%, Missing); smooth muscle: 88.8889% (minimum 99%, Missing); spinal cord: 40.0000% (minimum 99%, Missing); spleen: 88.8889% (minimum 95%, Missing); stomach: 88.8889% (minimum 97%, Missing); thyroid gland: 88.8889% (minimum 95%, Missing); urinary bladder: 88.8889% (minimum 97%, Missing)",-0.15,-0.17,-0.67,0,80,unavailable,1.7,0.2,0.2,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204963,PCDHA7,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 32.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); midbrain: 61.5385% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing)",0.15,0.1,-0.43,0,80,unavailable,1.7,0.2,0.2,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204963,PCDHA7,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 32.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); midbrain: 61.5385% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing)",0.15,0.1,-0.43,0,80,unavailable,1.7,0.2,0.2,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204963,PCDHA7,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 32.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); midbrain: 61.5385% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing)",0.15,0.1,-0.43,0,80,unavailable,1.7,0.2,0.2,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204963,PCDHA7,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.7273% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 32.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.5385% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.7273% (minimum 75%, Baseline (adaptation disabled)); midbrain: 61.5385% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.7273% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 40.0000% (minimum 75%, Baseline (adaptation disabled))",0.15,0.1,-0.43,0,80,unavailable,1.7,0.2,0.2,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204963,PCDHA7,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.0000% (minimum 90%, Approved); adrenal gland: 75.0000% (minimum 98%, Approved); amygdala: 27.2727% (minimum 99%, Missing); basal ganglia: 37.5000% (minimum 99%, Missing); cerebellum: 9.6774% (minimum 99%, Missing); cerebral cortex: 12.5000% (minimum 99%, Missing); colon: 75.0000% (minimum 95%, Approved); hippocampal formation: 30.0000% (minimum 99%, Missing); hypothalamus: 30.0000% (minimum 99%, Missing); kidney: 75.0000% (minimum 98%, Approved); lung: 75.0000% (minimum 98%, Approved); midbrain: 37.5000% (minimum 99%, Missing); pancreas: 60.0000% (minimum 98%, Approved); pituitary gland: 37.5000% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing); spinal cord: 42.8571% (minimum 99%, Missing)",-0.15,-0.2,-0.893226,0,0,routine_complete,2.8,0.1,0.1,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),55,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204965,PCDHA5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 27.2727% (minimum 75%, Missing); basal ganglia: 37.5000% (minimum 75%, Missing); cerebellum: 9.6774% (minimum 75%, Missing); cerebral cortex: 12.5000% (minimum 75%, Missing); hippocampal formation: 30.0000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 37.5000% (minimum 75%, Missing); pancreas: 60.0000% (minimum 70%, Approved); pituitary gland: 37.5000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); spinal cord: 42.8571% (minimum 75%, Missing)",0.15,0.1,-0.653226,0,0,routine_complete,2.8,0.1,0.1,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),55,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204965,PCDHA5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 27.2727% (minimum 75%, Missing); basal ganglia: 37.5000% (minimum 75%, Missing); cerebellum: 9.6774% (minimum 75%, Missing); cerebral cortex: 12.5000% (minimum 75%, Missing); hippocampal formation: 30.0000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 37.5000% (minimum 75%, Missing); pancreas: 60.0000% (minimum 70%, Approved); pituitary gland: 37.5000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); spinal cord: 42.8571% (minimum 75%, Missing)",0.15,0.1,-0.653226,0,0,routine_complete,2.8,0.1,0.1,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),55,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204965,PCDHA5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 27.2727% (minimum 75%, Missing); basal ganglia: 37.5000% (minimum 75%, Missing); cerebellum: 9.6774% (minimum 75%, Missing); cerebral cortex: 12.5000% (minimum 75%, Missing); hippocampal formation: 30.0000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 37.5000% (minimum 75%, Missing); pancreas: 60.0000% (minimum 70%, Approved); pituitary gland: 37.5000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); spinal cord: 42.8571% (minimum 75%, Missing)",0.15,0.1,-0.653226,0,0,routine_complete,2.8,0.1,0.1,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),55,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204965,PCDHA5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 27.2727% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 37.5000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 9.6774% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 12.5000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 30.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 30.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 37.5000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 37.5000% (minimum 75%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 42.8571% (minimum 75%, Baseline (adaptation disabled))",0.1,0.05,-0.653226,0,0,routine_complete,2.8,0.1,0.1,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),55,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204965,PCDHA5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4286% (minimum 90%, Approved); adrenal gland: 83.3333% (minimum 98%, Approved); amygdala: 38.4615% (minimum 99%, Missing); basal ganglia: 33.3333% (minimum 99%, Missing); bone marrow: 38.4615% (minimum 98%, Approved); cerebellum: 22.7273% (minimum 99%, Missing); cerebral cortex: 20.0000% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 71.4286% (minimum 97%, Missing); duodenum: 71.4286% (minimum 99%, Missing); esophagus: 83.3333% (minimum 95%, Approved); heart muscle: 83.3333% (minimum 98%, Approved); hippocampal formation: 38.4615% (minimum 99%, Missing); hypothalamus: 35.7143% (minimum 99%, Missing); kidney: 55.5556% (minimum 99%, Missing); liver: 83.3333% (minimum 98%, Approved); lung: 55.5556% (minimum 98%, Approved); lymph node: 62.5000% (minimum 95%, Approved); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 29.4118% (minimum 99%, Missing); parathyroid gland: 83.3333% (minimum 95%, Approved); pituitary gland: 62.5000% (minimum 99%, Missing); rectum: 71.4286% (minimum 97%, Missing); retina: 38.4615% (minimum 99%, Missing); salivary gland: 71.4286% (minimum 95%, Approved); skeletal muscle: 71.4286% (minimum 98%, Approved); skin: 55.5556% (minimum 90%, Approved); small intestine: 71.4286% (minimum 99%, Missing); smooth muscle: 62.5000% (minimum 98%, Approved); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 71.4286% (minimum 90%, Approved); stomach: 71.4286% (minimum 97%, Missing); thymus: 83.3333% (minimum 95%, Missing); thyroid gland: 71.4286% (minimum 90%, Approved); tongue: 83.3333% (minimum 97%, Missing); urinary bladder: 71.4286% (minimum 97%, Missing)",-0.344444,-0.325,-0.79,0,3,partial,2,0.3,0.4,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204967,PCDHA4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 38.4615% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); bone marrow: 38.4615% (minimum 70%, Approved); cerebellum: 22.7273% (minimum 75%, Missing); cerebral cortex: 20.0000% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); hippocampal formation: 38.4615% (minimum 75%, Missing); hypothalamus: 35.7143% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); lung: 55.5556% (minimum 70%, Approved); lymph node: 62.5000% (minimum 65%, Approved); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 29.4118% (minimum 75%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); retina: 38.4615% (minimum 75%, Missing); skin: 55.5556% (minimum 60%, Approved); small intestine: 71.4286% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 70%, Approved); spinal cord: 50.0000% (minimum 75%, Missing)",-0.0444444,-0.025,-0.55,0,3,partial,2,0.3,0.4,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204967,PCDHA4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 38.4615% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); bone marrow: 38.4615% (minimum 70%, Approved); cerebellum: 22.7273% (minimum 75%, Missing); cerebral cortex: 20.0000% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); hippocampal formation: 38.4615% (minimum 75%, Missing); hypothalamus: 35.7143% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); lung: 55.5556% (minimum 70%, Approved); lymph node: 62.5000% (minimum 65%, Approved); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 29.4118% (minimum 75%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); retina: 38.4615% (minimum 75%, Missing); skin: 55.5556% (minimum 60%, Approved); small intestine: 71.4286% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 70%, Approved); spinal cord: 50.0000% (minimum 75%, Missing)",-0.0444444,-0.025,-0.55,0,3,partial,2,0.3,0.4,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204967,PCDHA4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 38.4615% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); bone marrow: 38.4615% (minimum 70%, Approved); cerebellum: 22.7273% (minimum 75%, Missing); cerebral cortex: 20.0000% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); hippocampal formation: 38.4615% (minimum 75%, Missing); hypothalamus: 35.7143% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); lung: 55.5556% (minimum 70%, Approved); lymph node: 62.5000% (minimum 65%, Approved); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 29.4118% (minimum 75%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); retina: 38.4615% (minimum 75%, Missing); skin: 55.5556% (minimum 60%, Approved); small intestine: 71.4286% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 70%, Approved); spinal cord: 50.0000% (minimum 75%, Missing)",-0.0444444,-0.025,-0.55,0,3,partial,2,0.3,0.4,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204967,PCDHA4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 38.4615% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 33.3333% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 38.4615% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 22.7273% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 20.0000% (minimum 75%, Baseline (adaptation disabled)); duodenum: 71.4286% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 38.4615% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 35.7143% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.5556% (minimum 75%, Baseline (adaptation disabled)); lung: 55.5556% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.5000% (minimum 70%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 29.4118% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 62.5000% (minimum 75%, Baseline (adaptation disabled)); retina: 38.4615% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 71.4286% (minimum 75%, Baseline (adaptation disabled)); skin: 55.5556% (minimum 65%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.5000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 75%, Baseline (adaptation disabled))",-0.0944444,-0.075,-0.55,0,3,partial,2,0.3,0.4,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204967,PCDHA4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.8889% (minimum 95%, Missing); adrenal gland: 88.8889% (minimum 99%, Missing); amygdala: 53.3333% (minimum 99%, Missing); basal ganglia: 57.1429% (minimum 99%, Missing); cerebellum: 25.0000% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); heart muscle: 88.8889% (minimum 99%, Missing); hippocampal formation: 53.3333% (minimum 99%, Missing); hypothalamus: 57.1429% (minimum 99%, Missing); kidney: 72.7273% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 72.7273% (minimum 99%, Missing); pituitary gland: 32.0000% (minimum 99%, Missing); retina: 61.5385% (minimum 99%, Missing); small intestine: 88.8889% (minimum 99%, Missing); spinal cord: 61.5385% (minimum 99%, Missing); spleen: 88.8889% (minimum 95%, Missing); stomach: 88.8889% (minimum 97%, Missing); thyroid gland: 88.8889% (minimum 95%, Missing)",-0.0611111,-0.17,-0.74,0,80,unavailable,2.4,0.2,0.1,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204969,PCDHA2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 57.1429% (minimum 75%, Missing); cerebellum: 25.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 53.3333% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); pituitary gland: 32.0000% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing)",0.238889,0.1,-0.5,0,80,unavailable,2.4,0.2,0.1,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204969,PCDHA2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 57.1429% (minimum 75%, Missing); cerebellum: 25.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 53.3333% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); pituitary gland: 32.0000% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing)",0.238889,0.1,-0.5,0,80,unavailable,2.4,0.2,0.1,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204969,PCDHA2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 57.1429% (minimum 75%, Missing); cerebellum: 25.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 53.3333% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); pituitary gland: 32.0000% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing)",0.238889,0.1,-0.5,0,80,unavailable,2.4,0.2,0.1,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204969,PCDHA2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 53.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 57.1429% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 25.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 53.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 57.1429% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.7273% (minimum 75%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 72.7273% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 32.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 61.5385% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.5385% (minimum 75%, Baseline (adaptation disabled))",0.238889,0.1,-0.5,0,80,unavailable,2.4,0.2,0.1,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204969,PCDHA2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 83.3333% (minimum 95%, Enhanced); amygdala: 40.0000% (minimum 99%, Missing); basal ganglia: 32.2581% (minimum 99%, Missing); cerebellum: 30.3030% (minimum 95%, Enhanced); cerebral cortex: 31.2500% (minimum 99%, Missing); duodenum: 90.9091% (minimum 95%, Enhanced); hippocampal formation: 35.7143% (minimum 99%, Missing); hypothalamus: 35.7143% (minimum 99%, Missing); kidney: 90.9091% (minimum 95%, Enhanced); midbrain: 41.6667% (minimum 99%, Missing); pancreas: 90.9091% (minimum 95%, Enhanced); pituitary gland: 50.0000% (minimum 99%, Missing); retina: 76.9231% (minimum 99%, Missing); small intestine: 90.9091% (minimum 95%, Enhanced); spinal cord: 26.3158% (minimum 99%, Missing)",0.05,0.03,-0.726842,0,1,partial,2.8,0.1,0,"spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204970,PCDHA1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 40.0000% (minimum 75%, Missing); basal ganglia: 32.2581% (minimum 75%, Missing); cerebellum: 30.3030% (minimum 60%, Enhanced); cerebral cortex: 31.2500% (minimum 75%, Missing); hippocampal formation: 35.7143% (minimum 75%, Missing); hypothalamus: 35.7143% (minimum 75%, Missing); midbrain: 41.6667% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); spinal cord: 26.3158% (minimum 75%, Missing)",0.35,0.3,-0.486842,0,1,partial,2.8,0.1,0,"spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204970,PCDHA1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 40.0000% (minimum 75%, Missing); basal ganglia: 32.2581% (minimum 75%, Missing); cerebellum: 30.3030% (minimum 60%, Enhanced); cerebral cortex: 31.2500% (minimum 75%, Missing); hippocampal formation: 35.7143% (minimum 75%, Missing); hypothalamus: 35.7143% (minimum 75%, Missing); midbrain: 41.6667% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); spinal cord: 26.3158% (minimum 75%, Missing)",0.35,0.3,-0.486842,0,1,partial,2.8,0.1,0,"spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204970,PCDHA1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 40.0000% (minimum 75%, Missing); basal ganglia: 32.2581% (minimum 75%, Missing); cerebellum: 30.3030% (minimum 60%, Enhanced); cerebral cortex: 31.2500% (minimum 75%, Missing); hippocampal formation: 35.7143% (minimum 75%, Missing); hypothalamus: 35.7143% (minimum 75%, Missing); midbrain: 41.6667% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); spinal cord: 26.3158% (minimum 75%, Missing)",0.35,0.3,-0.486842,0,1,partial,2.8,0.1,0,"spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204970,PCDHA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 40.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 32.2581% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 30.3030% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 31.2500% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 35.7143% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 35.7143% (minimum 75%, Baseline (adaptation disabled)); midbrain: 41.6667% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 26.3158% (minimum 75%, Baseline (adaptation disabled))",0.35,0.209091,-0.486842,0,1,partial,2.8,0.1,0,"spinal cord: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204970,PCDHA1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204979,MS4A13,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204979,MS4A13,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204979,MS4A13,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204979,MS4A13,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000204979,MS4A13,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.7638% (minimum 95%, Missing); adrenal gland: 94.2149% (minimum 99%, Missing); amygdala: 89.4118% (minimum 99%, Missing); basal ganglia: 91.9355% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 90.4762% (minimum 99%, Missing); cerebral cortex: 91.9355% (minimum 99%, Missing); choroid plexus: 91.9355% (minimum 99%, Missing); colon: 93.0612% (minimum 97%, Missing); duodenum: 97.0213% (minimum 99%, Missing); esophagus: 93.8272% (minimum 97%, Missing); heart muscle: 94.6058% (minimum 99%, Missing); hippocampal formation: 90.1186% (minimum 99%, Missing); hypothalamus: 88.0309% (minimum 99%, Missing); kidney: 88.0309% (minimum 99%, Missing); liver: 94.2149% (minimum 99%, Missing); lung: 94.2149% (minimum 99%, Missing); lymph node: 96.2025% (minimum 97%, Missing); midbrain: 91.9355% (minimum 99%, Missing); pancreas: 92.3077% (minimum 99%, Missing); pituitary gland: 91.5663% (minimum 99%, Missing); retina: 89.4118% (minimum 99%, Missing); salivary gland: 82.3105% (minimum 97%, Missing); skeletal muscle: 96.6102% (minimum 99%, Missing); skin: 89.0625% (minimum 95%, Missing); small intestine: 91.5663% (minimum 99%, Missing); smooth muscle: 98.2759% (minimum 99%, Missing); spinal cord: 91.2000% (minimum 99%, Missing); spleen: 91.9355% (minimum 95%, Missing); stomach: 95.3975% (minimum 97%, Missing); thyroid gland: 87.3563% (minimum 95%, Missing); urinary bladder: 90.8367% (minimum 97%, Missing)",-0.0764368,-0.146895,-0.109691,0,80,unavailable,3.1,4.9,3.3,"salivary gland: 4.9 nTPM (protected, limit 2); kidney: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205078,SYCE1L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.223563,0.123105,0.130309,0,80,unavailable,3.1,4.9,3.3,"salivary gland: 4.9 nTPM (protected, limit 2); kidney: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205078,SYCE1L,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.223563,0.123105,0.130309,0,80,unavailable,3.1,4.9,3.3,"salivary gland: 4.9 nTPM (protected, limit 3); kidney: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205078,SYCE1L,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.223563,0.123105,0.130309,0,80,unavailable,3.1,4.9,3.3,"salivary gland: 4.9 nTPM (protected, limit 3); kidney: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205078,SYCE1L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.223563,0.123105,0.130309,0,80,unavailable,3.1,4.9,3.3,"salivary gland: 4.9 nTPM (protected, limit 3); kidney: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205078,SYCE1L,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.6702% (minimum 95%, Enhanced); amygdala: 95.9350% (minimum 99%, Missing); basal ganglia: 94.1489% (minimum 99%, Missing); cerebellum: 91.7098% (minimum 95%, Enhanced); cerebral cortex: 93.1579% (minimum 95%, Enhanced); choroid plexus: 97.7901% (minimum 99%, Missing); heart muscle: 91.4729% (minimum 95%, Enhanced); hippocampal formation: 95.9350% (minimum 99%, Missing); hypothalamus: 95.9350% (minimum 99%, Missing); kidney: 91.9481% (minimum 95%, Enhanced); midbrain: 95.6757% (minimum 99%, Missing); pituitary gland: 89.1688% (minimum 99%, Missing); retina: 95.1613% (minimum 99%, Missing); spinal cord: 95.4178% (minimum 99%, Missing)",0.0471831,0.03,-0.0983123,0,1,partial,4.3,2.3,2.6,"pituitary gland: 4.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205085,GARIN1A,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347183,0.3,0.141688,0,1,partial,4.3,2.3,2.6,"pituitary gland: 4.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205085,GARIN1A,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347183,0.3,0.141688,0,1,partial,4.3,2.3,2.6,"pituitary gland: 4.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205085,GARIN1A,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347183,0.3,0.141688,0,1,partial,4.3,2.3,2.6,"pituitary gland: 4.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205085,GARIN1A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.281579,0.238992,0.141688,0,1,partial,4.3,2.3,2.6,"pituitary gland: 4.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205085,GARIN1A,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205108,SPATA31F1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205108,SPATA31F1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205108,SPATA31F1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205108,SPATA31F1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345868,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205108,SPATA31F1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 95.2381% (minimum 99%, Missing); basal ganglia: 90.9091% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 99%, Missing); choroid plexus: 74.0741% (minimum 99%, Missing); heart muscle: 95.2381% (minimum 99%, Missing); hippocampal formation: 95.2381% (minimum 99%, Missing); hypothalamus: 86.9565% (minimum 99%, Missing); kidney: 95.2381% (minimum 99%, Missing); lung: 95.2381% (minimum 99%, Missing); midbrain: 95.2381% (minimum 99%, Missing); parathyroid gland: 95.2381% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); retina: 95.2381% (minimum 99%, Missing); skeletal muscle: 95.2381% (minimum 99%, Missing); spinal cord: 95.2381% (minimum 99%, Missing)",0.00238095,-0.017619,-0.249259,0,80,unavailable,0.7,0.1,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205111,CDKL4,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 74.0741% (minimum 75%, Missing)",0.302381,0.252381,-0.00925926,0,80,unavailable,0.7,0.1,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205111,CDKL4,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 74.0741% (minimum 75%, Missing)",0.302381,0.252381,-0.00925926,0,80,unavailable,0.7,0.1,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205111,CDKL4,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 74.0741% (minimum 75%, Missing)",0.302381,0.252381,-0.00925926,0,80,unavailable,0.7,0.1,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205111,CDKL4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 74.0741% (minimum 75%, Baseline (adaptation disabled))",0.302381,0.252381,-0.00925926,0,80,unavailable,0.7,0.1,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205111,CDKL4,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 85.2941% (minimum 99%, Missing); basal ganglia: 71.6049% (minimum 99%, Missing); cerebellum: 92.8000% (minimum 95%, Enhanced); cerebral cortex: 92.8000% (minimum 95%, Enhanced); choroid plexus: 27.3585% (minimum 99%, Missing); heart muscle: 92.8000% (minimum 95%, Enhanced); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 78.9116% (minimum 99%, Missing); kidney: 81.6901% (minimum 95%, Enhanced); lung: 87.2180% (minimum 95%, Enhanced); midbrain: 89.2308% (minimum 99%, Missing); pancreas: 94.3089% (minimum 95%, Enhanced); pituitary gland: 80.5556% (minimum 99%, Missing); retina: 46.9636% (minimum 99%, Missing); spinal cord: 87.8788% (minimum 99%, Missing)",0.0330508,0.021453,-0.716415,0,4,partial,30.8,0.5,4.1,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205129,CFAP96,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.6049% (minimum 75%, Missing); choroid plexus: 27.3585% (minimum 75%, Missing); retina: 46.9636% (minimum 75%, Missing)",0.238854,0.291453,-0.476415,0,4,partial,30.8,0.5,4.1,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205129,CFAP96,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.6049% (minimum 75%, Missing); choroid plexus: 27.3585% (minimum 75%, Missing); retina: 46.9636% (minimum 75%, Missing)",0.238854,0.291453,-0.476415,0,4,partial,30.8,0.5,4.1,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205129,CFAP96,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.6049% (minimum 75%, Missing); choroid plexus: 27.3585% (minimum 75%, Missing); retina: 46.9636% (minimum 75%, Missing)",0.238854,0.291453,-0.476415,0,4,partial,30.8,0.5,4.1,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205129,CFAP96,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.6049% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 27.3585% (minimum 75%, Baseline (adaptation disabled)); retina: 46.9636% (minimum 75%, Baseline (adaptation disabled))",0.0888535,0.258678,-0.476415,0,4,partial,30.8,0.5,4.1,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205129,CFAP96,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.5769% (minimum 95%, Missing); adrenal gland: 47.1322% (minimum 99%, Missing); amygdala: 60.5769% (minimum 99%, Missing); basal ganglia: 56.0831% (minimum 99%, Missing); bone marrow: 56.9277% (minimum 99%, Missing); cerebellum: 54.6243% (minimum 99%, Missing); cerebral cortex: 51.7808% (minimum 99%, Missing); choroid plexus: 70.0000% (minimum 99%, Missing); colon: 48.5861% (minimum 97%, Missing); duodenum: 61.1650% (minimum 99%, Missing); esophagus: 66.5493% (minimum 97%, Missing); heart muscle: 49.3473% (minimum 99%, Missing); hippocampal formation: 61.7647% (minimum 99%, Missing); hypothalamus: 61.9672% (minimum 99%, Missing); kidney: 50.2660% (minimum 99%, Missing); liver: 38.3367% (minimum 99%, Missing); lung: 53.3898% (minimum 99%, Missing); lymph node: 78.4232% (minimum 97%, Missing); midbrain: 62.3762% (minimum 99%, Missing); pancreas: 52.0661% (minimum 99%, Missing); parathyroid gland: 48.7113% (minimum 97%, Missing); pituitary gland: 64.5051% (minimum 99%, Missing); rectum: 48.2143% (minimum 97%, Missing); retina: 61.1650% (minimum 99%, Missing); salivary gland: 63.6364% (minimum 97%, Missing); skeletal muscle: 89.1509% (minimum 99%, Missing); skin: 77.4590% (minimum 95%, Missing); small intestine: 61.5635% (minimum 99%, Missing); smooth muscle: 63.2107% (minimum 99%, Missing); spinal cord: 54.7826% (minimum 99%, Missing); spleen: 59.6215% (minimum 95%, Missing); stomach: 52.6462% (minimum 97%, Missing); thymus: 72.6923% (minimum 95%, Missing); thyroid gland: 45.4327% (minimum 95%, Missing); tongue: 77.7778% (minimum 97%, Missing); urinary bladder: 55.9172% (minimum 97%, Missing)",-0.495673,-0.487857,-0.606633,0,80,unavailable,30.4,20.3,22.7,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 2); colon: 20 nTPM (protected, limit 2); parathyroid gland: 19.9 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 2); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 2); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); adipose tissue: 12.3 nTPM (manageable, limit 5); amygdala: 12.3 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); salivary gland: 10.8 nTPM (protected, limit 2); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 2); choroid plexus: 8.1 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 2); lymph node: 5.2 nTPM (protected, limit 2); skeletal muscle: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205133,TRIQK,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.5769% (minimum 65%, Missing); adrenal gland: 47.1322% (minimum 75%, Missing); amygdala: 60.5769% (minimum 75%, Missing); basal ganglia: 56.0831% (minimum 75%, Missing); bone marrow: 56.9277% (minimum 75%, Missing); cerebellum: 54.6243% (minimum 75%, Missing); cerebral cortex: 51.7808% (minimum 75%, Missing); choroid plexus: 70.0000% (minimum 75%, Missing); colon: 48.5861% (minimum 70%, Missing); duodenum: 61.1650% (minimum 75%, Missing); esophagus: 66.5493% (minimum 70%, Missing); heart muscle: 49.3473% (minimum 75%, Missing); hippocampal formation: 61.7647% (minimum 75%, Missing); hypothalamus: 61.9672% (minimum 75%, Missing); kidney: 50.2660% (minimum 75%, Missing); liver: 38.3367% (minimum 75%, Missing); lung: 53.3898% (minimum 75%, Missing); midbrain: 62.3762% (minimum 75%, Missing); pancreas: 52.0661% (minimum 75%, Missing); parathyroid gland: 48.7113% (minimum 70%, Missing); pituitary gland: 64.5051% (minimum 75%, Missing); rectum: 48.2143% (minimum 70%, Missing); retina: 61.1650% (minimum 75%, Missing); salivary gland: 63.6364% (minimum 70%, Missing); small intestine: 61.5635% (minimum 75%, Missing); smooth muscle: 63.2107% (minimum 75%, Missing); spinal cord: 54.7826% (minimum 75%, Missing); spleen: 59.6215% (minimum 65%, Missing); stomach: 52.6462% (minimum 70%, Missing); thyroid gland: 45.4327% (minimum 65%, Missing); urinary bladder: 55.9172% (minimum 70%, Missing)",-0.195673,-0.217857,-0.366633,0,80,unavailable,30.4,20.3,22.7,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 2); colon: 20 nTPM (protected, limit 2); parathyroid gland: 19.9 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 2); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 2); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); adipose tissue: 12.3 nTPM (manageable, limit 5); amygdala: 12.3 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); salivary gland: 10.8 nTPM (protected, limit 2); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 2); choroid plexus: 8.1 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 2); lymph node: 5.2 nTPM (protected, limit 2); skeletal muscle: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205133,TRIQK,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.5769% (minimum 65%, Missing); adrenal gland: 47.1322% (minimum 75%, Missing); amygdala: 60.5769% (minimum 75%, Missing); basal ganglia: 56.0831% (minimum 75%, Missing); bone marrow: 56.9277% (minimum 75%, Missing); cerebellum: 54.6243% (minimum 75%, Missing); cerebral cortex: 51.7808% (minimum 75%, Missing); choroid plexus: 70.0000% (minimum 75%, Missing); colon: 48.5861% (minimum 70%, Missing); duodenum: 61.1650% (minimum 75%, Missing); esophagus: 66.5493% (minimum 70%, Missing); heart muscle: 49.3473% (minimum 75%, Missing); hippocampal formation: 61.7647% (minimum 75%, Missing); hypothalamus: 61.9672% (minimum 75%, Missing); kidney: 50.2660% (minimum 75%, Missing); liver: 38.3367% (minimum 75%, Missing); lung: 53.3898% (minimum 75%, Missing); midbrain: 62.3762% (minimum 75%, Missing); pancreas: 52.0661% (minimum 75%, Missing); parathyroid gland: 48.7113% (minimum 70%, Missing); pituitary gland: 64.5051% (minimum 75%, Missing); rectum: 48.2143% (minimum 70%, Missing); retina: 61.1650% (minimum 75%, Missing); salivary gland: 63.6364% (minimum 70%, Missing); small intestine: 61.5635% (minimum 75%, Missing); smooth muscle: 63.2107% (minimum 75%, Missing); spinal cord: 54.7826% (minimum 75%, Missing); spleen: 59.6215% (minimum 65%, Missing); stomach: 52.6462% (minimum 70%, Missing); thyroid gland: 45.4327% (minimum 65%, Missing); urinary bladder: 55.9172% (minimum 70%, Missing)",-0.195673,-0.217857,-0.366633,0,80,unavailable,30.4,20.3,22.7,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 3); colon: 20 nTPM (protected, limit 3); parathyroid gland: 19.9 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 3); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 3); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); adipose tissue: 12.3 nTPM (manageable, limit 5); amygdala: 12.3 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); salivary gland: 10.8 nTPM (protected, limit 3); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 3); choroid plexus: 8.1 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 3); lymph node: 5.2 nTPM (protected, limit 3); skeletal muscle: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205133,TRIQK,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.5769% (minimum 65%, Missing); adrenal gland: 47.1322% (minimum 75%, Missing); amygdala: 60.5769% (minimum 75%, Missing); basal ganglia: 56.0831% (minimum 75%, Missing); bone marrow: 56.9277% (minimum 75%, Missing); cerebellum: 54.6243% (minimum 75%, Missing); cerebral cortex: 51.7808% (minimum 75%, Missing); choroid plexus: 70.0000% (minimum 75%, Missing); colon: 48.5861% (minimum 70%, Missing); duodenum: 61.1650% (minimum 75%, Missing); esophagus: 66.5493% (minimum 70%, Missing); heart muscle: 49.3473% (minimum 75%, Missing); hippocampal formation: 61.7647% (minimum 75%, Missing); hypothalamus: 61.9672% (minimum 75%, Missing); kidney: 50.2660% (minimum 75%, Missing); liver: 38.3367% (minimum 75%, Missing); lung: 53.3898% (minimum 75%, Missing); midbrain: 62.3762% (minimum 75%, Missing); pancreas: 52.0661% (minimum 75%, Missing); parathyroid gland: 48.7113% (minimum 70%, Missing); pituitary gland: 64.5051% (minimum 75%, Missing); rectum: 48.2143% (minimum 70%, Missing); retina: 61.1650% (minimum 75%, Missing); salivary gland: 63.6364% (minimum 70%, Missing); small intestine: 61.5635% (minimum 75%, Missing); smooth muscle: 63.2107% (minimum 75%, Missing); spinal cord: 54.7826% (minimum 75%, Missing); spleen: 59.6215% (minimum 65%, Missing); stomach: 52.6462% (minimum 70%, Missing); thyroid gland: 45.4327% (minimum 65%, Missing); urinary bladder: 55.9172% (minimum 70%, Missing)",-0.195673,-0.217857,-0.366633,0,80,unavailable,30.4,20.3,22.7,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 3); colon: 20 nTPM (protected, limit 3); parathyroid gland: 19.9 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 3); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 3); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); adipose tissue: 12.3 nTPM (manageable, limit 5); amygdala: 12.3 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); salivary gland: 10.8 nTPM (protected, limit 3); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 3); choroid plexus: 8.1 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 3); lymph node: 5.2 nTPM (protected, limit 3); skeletal muscle: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205133,TRIQK,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.5769% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 47.1322% (minimum 75%, Baseline (adaptation disabled)); amygdala: 60.5769% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.0831% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 56.9277% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.6243% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 51.7808% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 70.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 48.5861% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.1650% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.5493% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 49.3473% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.7647% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.9672% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.2660% (minimum 75%, Baseline (adaptation disabled)); liver: 38.3367% (minimum 75%, Baseline (adaptation disabled)); lung: 53.3898% (minimum 75%, Baseline (adaptation disabled)); midbrain: 62.3762% (minimum 75%, Baseline (adaptation disabled)); pancreas: 52.0661% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 48.7113% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 64.5051% (minimum 75%, Baseline (adaptation disabled)); rectum: 48.2143% (minimum 70%, Baseline (adaptation disabled)); retina: 61.1650% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.6364% (minimum 70%, Baseline (adaptation disabled)); small intestine: 61.5635% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.2107% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 54.7826% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.6215% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.6462% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 45.4327% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 55.9172% (minimum 70%, Baseline (adaptation disabled))",-0.195673,-0.217857,-0.366633,0,80,unavailable,30.4,20.3,22.7,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 3); colon: 20 nTPM (protected, limit 3); parathyroid gland: 19.9 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 3); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 3); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); adipose tissue: 12.3 nTPM (manageable, limit 5); amygdala: 12.3 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); salivary gland: 10.8 nTPM (protected, limit 3); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 3); choroid plexus: 8.1 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 3); lymph node: 5.2 nTPM (protected, limit 3); skeletal muscle: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205133,TRIQK,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.9065% (minimum 95%, Missing); adrenal gland: 97.8947% (minimum 99%, Missing); amygdala: 95.8763% (minimum 99%, Missing); basal ganglia: 96.8750% (minimum 99%, Missing); bone marrow: 90.2913% (minimum 99%, Missing); cerebellum: 98.9362% (minimum 99%, Missing); cerebral cortex: 96.8750% (minimum 99%, Missing); colon: 95.8763% (minimum 97%, Missing); esophagus: 76.2295% (minimum 97%, Missing); heart muscle: 92.0792% (minimum 99%, Missing); hippocampal formation: 97.8947% (minimum 99%, Missing); hypothalamus: 95.8763% (minimum 99%, Missing); kidney: 87.7358% (minimum 99%, Missing); liver: 97.8947% (minimum 99%, Missing); lung: 89.4231% (minimum 99%, Missing); midbrain: 95.8763% (minimum 99%, Missing); pancreas: 86.1111% (minimum 99%, Missing); pituitary gland: 98.9362% (minimum 99%, Missing); retina: 98.9362% (minimum 99%, Missing); salivary gland: 94.8980% (minimum 97%, Missing); skeletal muscle: 94.8980% (minimum 99%, Missing); skin: 90.2913% (minimum 95%, Missing); small intestine: 96.8750% (minimum 99%, Missing); smooth muscle: 93.0000% (minimum 99%, Missing); spinal cord: 97.8947% (minimum 99%, Missing); stomach: 82.3009% (minimum 97%, Missing); urinary bladder: 86.9159% (minimum 97%, Missing)",-0.280935,-0.207705,-0.128889,0,80,unavailable,1.5,2.9,4.6,"esophagus: 2.9 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205177,C11orf91,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0190647,0.0622951,0.111111,0,80,unavailable,1.5,2.9,4.6,"esophagus: 2.9 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205177,C11orf91,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0190647,0.0622951,0.111111,0,80,unavailable,1.5,2.9,4.6,"pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205177,C11orf91,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0190647,0.0622951,0.111111,0,80,unavailable,1.5,2.9,4.6,"pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205177,C11orf91,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0190647,0.0622951,0.111111,0,80,unavailable,1.5,2.9,4.6,"pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205177,C11orf91,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.7838% (minimum 95%, Uncertain); adrenal gland: 84.3537% (minimum 99%, Uncertain); amygdala: 88.5714% (minimum 99%, Missing); basal ganglia: 89.8551% (minimum 99%, Missing); bone marrow: 46.4419% (minimum 99%, Uncertain); cerebellum: 84.3537% (minimum 99%, Uncertain); cerebral cortex: 84.9315% (minimum 99%, Missing); choroid plexus: 96.8750% (minimum 99%, Missing); colon: 79.4872% (minimum 97%, Missing); duodenum: 81.0458% (minimum 99%, Uncertain); esophagus: 81.5789% (minimum 97%, Uncertain); heart muscle: 77.9874% (minimum 99%, Missing); hippocampal formation: 87.9433% (minimum 99%, Missing); hypothalamus: 89.8551% (minimum 99%, Missing); kidney: 86.7133% (minimum 99%, Missing); liver: 89.2086% (minimum 99%, Uncertain); lung: 83.2215% (minimum 99%, Uncertain); lymph node: 67.7596% (minimum 97%, Missing); midbrain: 87.9433% (minimum 99%, Missing); pancreas: 84.3537% (minimum 99%, Uncertain); parathyroid gland: 87.9433% (minimum 97%, Uncertain); pituitary gland: 91.8519% (minimum 99%, Missing); rectum: 75.6098% (minimum 97%, Uncertain); retina: 57.4074% (minimum 99%, Missing); salivary gland: 87.9433% (minimum 97%, Uncertain); skeletal muscle: 86.1111% (minimum 99%, Missing); skin: 81.5789% (minimum 95%, Missing); small intestine: 82.1192% (minimum 99%, Missing); smooth muscle: 76.0736% (minimum 99%, Uncertain); spinal cord: 82.1192% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 83.2215% (minimum 97%, Uncertain); thymus: 55.6054% (minimum 95%, Missing); thyroid gland: 75.1515% (minimum 95%, Uncertain); tongue: 68.1319% (minimum 97%, Missing); urinary bladder: 83.2215% (minimum 97%, Uncertain)",-0.393946,-0.292404,-0.525581,0,1,partial,14.3,5.9,9.9,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 2); tongue: 5.8 nTPM (protected, limit 2); rectum: 4 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205208,C4orf46,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.4419% (minimum 75%, Uncertain); lymph node: 67.7596% (minimum 70%, Missing); retina: 57.4074% (minimum 75%, Missing); thymus: 55.6054% (minimum 65%, Missing); tongue: 68.1319% (minimum 70%, Missing)",-0.0939462,-0.0224044,-0.285581,0,1,partial,14.3,5.9,9.9,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 2); tongue: 5.8 nTPM (protected, limit 2); rectum: 4 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205208,C4orf46,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.4419% (minimum 75%, Uncertain); lymph node: 67.7596% (minimum 70%, Missing); retina: 57.4074% (minimum 75%, Missing); thymus: 55.6054% (minimum 65%, Missing); tongue: 68.1319% (minimum 70%, Missing)",-0.0939462,-0.0224044,-0.285581,0,1,partial,14.3,5.9,9.9,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 3); tongue: 5.8 nTPM (protected, limit 3); rectum: 4 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205208,C4orf46,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.4419% (minimum 75%, Uncertain); lymph node: 67.7596% (minimum 70%, Missing); retina: 57.4074% (minimum 75%, Missing); thymus: 55.6054% (minimum 65%, Missing); tongue: 68.1319% (minimum 70%, Missing)",-0.0939462,-0.0224044,-0.285581,0,1,partial,14.3,5.9,9.9,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 3); tongue: 5.8 nTPM (protected, limit 3); rectum: 4 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205208,C4orf46,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.4419% (minimum 75%, Baseline (adaptation disabled)); lymph node: 67.7596% (minimum 70%, Baseline (adaptation disabled)); retina: 57.4074% (minimum 75%, Baseline (adaptation disabled)); thymus: 55.6054% (minimum 65%, Baseline (adaptation disabled)); tongue: 68.1319% (minimum 70%, Baseline (adaptation disabled))",-0.0939462,-0.0224044,-0.285581,0,1,partial,14.3,5.9,9.9,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 3); tongue: 5.8 nTPM (protected, limit 3); rectum: 4 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205208,C4orf46,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205301,MGAT4D,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205301,MGAT4D,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205301,MGAT4D,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205301,MGAT4D,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.245475,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205301,MGAT4D,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205359,SLCO6A1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205359,SLCO6A1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205359,SLCO6A1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205359,SLCO6A1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205359,SLCO6A1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205409,OR52E6,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205409,OR52E6,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205409,OR52E6,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205409,OR52E6,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205409,OR52E6,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205442,IZUMO3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205442,IZUMO3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205442,IZUMO3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205442,IZUMO3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205442,IZUMO3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,14.6,"skin: 14.6 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205445,KRTAP10-2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,14.6,"skin: 14.6 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205445,KRTAP10-2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,14.6,"skin: 14.6 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205445,KRTAP10-2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,14.6,"skin: 14.6 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205445,KRTAP10-2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,14.6,"skin: 14.6 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205445,KRTAP10-2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 83.0189% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 84.6154% (minimum 99%, Missing); cerebellum: 68.7500% (minimum 99%, Missing); cerebral cortex: 84.6154% (minimum 99%, Missing); colon: 95.6522% (minimum 97%, Missing); esophagus: 86.2745% (minimum 97%, Missing); heart muscle: 93.6170% (minimum 99%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 84.6154% (minimum 99%, Missing); kidney: 89.7959% (minimum 99%, Missing); lung: 97.7778% (minimum 99%, Missing); lymph node: 93.6170% (minimum 97%, Missing); midbrain: 88.0000% (minimum 99%, Missing); pancreas: 97.7778% (minimum 99%, Missing); pituitary gland: 89.7959% (minimum 99%, Missing); retina: 97.7778% (minimum 99%, Missing); small intestine: 97.7778% (minimum 99%, Missing); smooth muscle: 97.7778% (minimum 99%, Missing); spinal cord: 81.4815% (minimum 99%, Missing); urinary bladder: 95.6522% (minimum 97%, Missing)",0.00652174,-0.107255,-0.3025,0,80,unavailable,2,0.7,0.2,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205456,TP53TG3D,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 68.7500% (minimum 75%, Missing)",0.306522,0.162745,-0.0625,0,80,unavailable,2,0.7,0.2,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205456,TP53TG3D,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 68.7500% (minimum 75%, Missing)",0.306522,0.162745,-0.0625,0,80,unavailable,2,0.7,0.2,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205456,TP53TG3D,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 68.7500% (minimum 75%, Missing)",0.306522,0.162745,-0.0625,0,80,unavailable,2,0.7,0.2,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205456,TP53TG3D,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 68.7500% (minimum 75%, Baseline (adaptation disabled))",0.306522,0.162745,-0.0625,0,80,unavailable,2,0.7,0.2,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205456,TP53TG3D,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 75.0000% (minimum 99%, Missing); pancreas: 60.0000% (minimum 99%, Missing)",0.05,0.03,-0.39,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205457,TP53TG3C,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 75.0000% (minimum 75%, Missing); pancreas: 60.0000% (minimum 75%, Missing)",0.35,0.3,-0.15,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205457,TP53TG3C,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 75.0000% (minimum 75%, Missing); pancreas: 60.0000% (minimum 75%, Missing)",0.35,0.3,-0.15,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205457,TP53TG3C,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 75.0000% (minimum 75%, Missing); pancreas: 60.0000% (minimum 75%, Missing)",0.35,0.3,-0.15,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205457,TP53TG3C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 75.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 60.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.15,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205457,TP53TG3C,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.4286% (minimum 99%, Missing); bone marrow: 4.0984% (minimum 99%, Missing); duodenum: 83.3333% (minimum 95%, Enhanced); lung: 71.4286% (minimum 95%, Enhanced); retina: 83.3333% (minimum 99%, Missing); skeletal muscle: 83.3333% (minimum 95%, Enhanced); spleen: 62.5000% (minimum 95%, Missing)",-0.325,0.03,-0.949016,0,4,partial,11.7,0,0.3,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; spleen / cells in red pulp; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205639,MFSD2B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing); bone marrow: 4.0984% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing)",-0.025,0.3,-0.709016,0,4,partial,11.7,0,0.3,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; spleen / cells in red pulp; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205639,MFSD2B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing); bone marrow: 4.0984% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing)",-0.025,0.3,-0.709016,0,4,partial,11.7,0,0.3,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; spleen / cells in red pulp; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205639,MFSD2B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing); bone marrow: 4.0984% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing)",-0.025,0.3,-0.709016,0,4,partial,11.7,0,0.3,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; spleen / cells in red pulp; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205639,MFSD2B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 4.0984% (minimum 75%, Baseline (adaptation disabled)); lung: 71.4286% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 65%, Baseline (adaptation disabled))",-0.025,0.3,-0.709016,0,4,partial,11.7,0,0.3,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; spleen / cells in red pulp; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205639,MFSD2B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 97.2414% (minimum 99%, Missing)",0.0429577,0.03,-0.0175862,0,7,partial,0.4,0,0.1,,,50,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205642,VCX3B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342958,0.3,0.222414,0,7,partial,0.4,0,0.1,,,50,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205642,VCX3B,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342958,0.3,0.222414,0,7,partial,0.4,0,0.1,,,50,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205642,VCX3B,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342958,0.3,0.222414,0,7,partial,0.4,0,0.1,,,50,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205642,VCX3B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342958,0.3,0.222414,0,7,partial,0.4,0,0.1,,,50,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205642,VCX3B,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 40.2556% (minimum 95%, Enhanced); choroid plexus: 98.4375% (minimum 99%, Missing); heart muscle: 33.3333% (minimum 95%, Enhanced); pancreas: 9.5382% (minimum 95%, Enhanced); pituitary gland: 88.1119% (minimum 99%, Missing); rectum: 79.7468% (minimum 80%, Enhanced); retina: 95.4545% (minimum 99%, Missing); salivary gland: 0.0096% (minimum 97%, Missing); skin: 56.5022% (minimum 60%, Enhanced)",-0.0349776,-0.969904,-0.854618,0,1,partial,119.5,131918,9.7,"salivary gland: 131918 nTPM (protected, limit 2); pancreas: 119.5 nTPM (vital, limit 6); heart muscle: 25.2 nTPM (vital, limit 6); bone marrow: 18.7 nTPM (vital, limit 6); pituitary gland: 1.7 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205649,HTN3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 40.2556% (minimum 60%, Enhanced); heart muscle: 33.3333% (minimum 60%, Enhanced); pancreas: 9.5382% (minimum 60%, Enhanced); salivary gland: 0.0096% (minimum 70%, Missing)",0.0650224,-0.699904,-0.504618,0,1,partial,119.5,131918,9.7,"salivary gland: 131918 nTPM (protected, limit 2); pancreas: 119.5 nTPM (vital, limit 6); heart muscle: 25.2 nTPM (vital, limit 6); bone marrow: 18.7 nTPM (vital, limit 6); pituitary gland: 1.7 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205649,HTN3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 40.2556% (minimum 60%, Enhanced); heart muscle: 33.3333% (minimum 60%, Enhanced); pancreas: 9.5382% (minimum 60%, Enhanced); salivary gland: 0.0096% (minimum 70%, Missing)",0.0650224,-0.699904,-0.504618,0,1,partial,119.5,131918,9.7,"salivary gland: 131918 nTPM (protected, limit 3); pancreas: 119.5 nTPM (vital, limit 6); heart muscle: 25.2 nTPM (vital, limit 6); bone marrow: 18.7 nTPM (vital, limit 6); pituitary gland: 1.7 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205649,HTN3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 40.2556% (minimum 60%, Enhanced); heart muscle: 33.3333% (minimum 60%, Enhanced); pancreas: 9.5382% (minimum 60%, Enhanced); salivary gland: 0.0096% (minimum 70%, Missing)",0.0650224,-0.699904,-0.504618,0,1,partial,119.5,131918,9.7,"salivary gland: 131918 nTPM (protected, limit 3); pancreas: 119.5 nTPM (vital, limit 6); heart muscle: 25.2 nTPM (vital, limit 6); bone marrow: 18.7 nTPM (vital, limit 6); pituitary gland: 1.7 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205649,HTN3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 40.2556% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 33.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 9.5382% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 0.0096% (minimum 70%, Baseline (adaptation disabled)); skin: 56.5022% (minimum 65%, Baseline (adaptation disabled))",-0.0849776,-0.699904,-0.654618,0,1,partial,119.5,131918,9.7,"salivary gland: 131918 nTPM (protected, limit 3); pancreas: 119.5 nTPM (vital, limit 1); heart muscle: 25.2 nTPM (vital, limit 1); bone marrow: 18.7 nTPM (vital, limit 1); skin: 9.7 nTPM (manageable, limit 5); rectum: 3.2 nTPM (protected, limit 3); pituitary gland: 1.7 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205649,HTN3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 66.7482% (minimum 90%, Approved); adrenal gland: 54.9296% (minimum 98%, Approved); amygdala: 63.1214% (minimum 99%, Missing); basal ganglia: 65.4676% (minimum 99%, Missing); bone marrow: 81.0089% (minimum 98%, Approved); cerebellum: 84.3895% (minimum 98%, Approved); cerebral cortex: 64.0094% (minimum 98%, Approved); choroid plexus: 80.0587% (minimum 99%, Missing); colon: 75.9388% (minimum 97%, Missing); duodenum: 62.6866% (minimum 98%, Approved); esophagus: 71.4660% (minimum 97%, Missing); heart muscle: 51.6068% (minimum 99%, Missing); hippocampal formation: 63.5623% (minimum 99%, Missing); hypothalamus: 67.6580% (minimum 99%, Missing); kidney: 50.3690% (minimum 98%, Approved); liver: 31.7073% (minimum 98%, Approved); lung: 72.2222% (minimum 99%, Missing); lymph node: 75.7282% (minimum 95%, Approved); midbrain: 58.5837% (minimum 99%, Missing); pancreas: 70.0899% (minimum 98%, Approved); parathyroid gland: 60.2649% (minimum 95%, Approved); pituitary gland: 78.7879% (minimum 99%, Missing); rectum: 74.3869% (minimum 95%, Approved); retina: 64.9227% (minimum 99%, Missing); salivary gland: 64.9227% (minimum 95%, Approved); skeletal muscle: 38.8612% (minimum 99%, Missing); skin: 69.8210% (minimum 95%, Missing); small intestine: 70.1799% (minimum 98%, Approved); smooth muscle: 75.6233% (minimum 98%, Approved); spinal cord: 43.7150% (minimum 99%, Missing); spleen: 75.4144% (minimum 90%, Approved); stomach: 64.9227% (minimum 97%, Missing); thymus: 74.7945% (minimum 95%, Missing); thyroid gland: 56.5803% (minimum 90%, Approved); tongue: 35.8739% (minimum 97%, Missing); urinary bladder: 75.8333% (minimum 95%, Approved)",-0.334197,-0.611261,-0.662927,0,3,partial,117.6,97.6,41.9,"liver: 117.6 nTPM (vital, limit 2); tongue: 97.6 nTPM (protected, limit 2); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 2); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 2); thyroid gland: 41.9 nTPM (manageable, limit 10); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 4); duodenum: 32.5 nTPM (vital, limit 2); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 2); stomach: 29.5 nTPM (protected, limit 2); salivary gland: 29.5 nTPM (protected, limit 4); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (manageable, limit 10); hypothalamus: 26.1 nTPM (vital, limit 1); skin: 23.6 nTPM (manageable, limit 5); pancreas: 23.3 nTPM (vital, limit 2); small intestine: 23.2 nTPM (vital, limit 2); esophagus: 21.8 nTPM (protected, limit 2); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 4); thymus: 18.4 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 10); smooth muscle: 17.6 nTPM (vital, limit 2); lymph node: 17.5 nTPM (protected, limit 4); urinary bladder: 17.4 nTPM (protected, limit 4); colon: 17.3 nTPM (protected, limit 2); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 2); cerebellum: 10.1 nTPM (vital, limit 2)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205707,ETFRF1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 54.9296% (minimum 70%, Approved); amygdala: 63.1214% (minimum 75%, Missing); basal ganglia: 65.4676% (minimum 75%, Missing); cerebral cortex: 64.0094% (minimum 70%, Approved); duodenum: 62.6866% (minimum 70%, Approved); heart muscle: 51.6068% (minimum 75%, Missing); hippocampal formation: 63.5623% (minimum 75%, Missing); hypothalamus: 67.6580% (minimum 75%, Missing); kidney: 50.3690% (minimum 70%, Approved); liver: 31.7073% (minimum 70%, Approved); lung: 72.2222% (minimum 75%, Missing); midbrain: 58.5837% (minimum 75%, Missing); parathyroid gland: 60.2649% (minimum 65%, Approved); retina: 64.9227% (minimum 75%, Missing); salivary gland: 64.9227% (minimum 65%, Approved); skeletal muscle: 38.8612% (minimum 75%, Missing); spinal cord: 43.7150% (minimum 75%, Missing); stomach: 64.9227% (minimum 70%, Missing); thyroid gland: 56.5803% (minimum 60%, Approved); tongue: 35.8739% (minimum 70%, Missing)",-0.0341969,-0.341261,-0.382927,0,3,partial,117.6,97.6,41.9,"liver: 117.6 nTPM (vital, limit 2); tongue: 97.6 nTPM (protected, limit 2); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 2); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 2); thyroid gland: 41.9 nTPM (manageable, limit 10); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 4); duodenum: 32.5 nTPM (vital, limit 2); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 2); stomach: 29.5 nTPM (protected, limit 2); salivary gland: 29.5 nTPM (protected, limit 4); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (manageable, limit 10); hypothalamus: 26.1 nTPM (vital, limit 1); skin: 23.6 nTPM (manageable, limit 5); pancreas: 23.3 nTPM (vital, limit 2); small intestine: 23.2 nTPM (vital, limit 2); esophagus: 21.8 nTPM (protected, limit 2); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 4); thymus: 18.4 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 10); smooth muscle: 17.6 nTPM (vital, limit 2); lymph node: 17.5 nTPM (protected, limit 4); urinary bladder: 17.4 nTPM (protected, limit 4); colon: 17.3 nTPM (protected, limit 2); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 2); cerebellum: 10.1 nTPM (vital, limit 2)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205707,ETFRF1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 54.9296% (minimum 70%, Approved); amygdala: 63.1214% (minimum 75%, Missing); basal ganglia: 65.4676% (minimum 75%, Missing); cerebral cortex: 64.0094% (minimum 70%, Approved); duodenum: 62.6866% (minimum 70%, Approved); heart muscle: 51.6068% (minimum 75%, Missing); hippocampal formation: 63.5623% (minimum 75%, Missing); hypothalamus: 67.6580% (minimum 75%, Missing); kidney: 50.3690% (minimum 70%, Approved); liver: 31.7073% (minimum 70%, Approved); lung: 72.2222% (minimum 75%, Missing); midbrain: 58.5837% (minimum 75%, Missing); parathyroid gland: 60.2649% (minimum 65%, Approved); retina: 64.9227% (minimum 75%, Missing); salivary gland: 64.9227% (minimum 65%, Approved); skeletal muscle: 38.8612% (minimum 75%, Missing); spinal cord: 43.7150% (minimum 75%, Missing); stomach: 64.9227% (minimum 70%, Missing); thyroid gland: 56.5803% (minimum 60%, Approved); tongue: 35.8739% (minimum 70%, Missing)",-0.0341969,-0.341261,-0.382927,0,3,partial,117.6,97.6,41.9,"liver: 117.6 nTPM (vital, limit 2); tongue: 97.6 nTPM (protected, limit 3); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 2); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 2); thyroid gland: 41.9 nTPM (manageable, limit 10); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 4); duodenum: 32.5 nTPM (vital, limit 2); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 2); stomach: 29.5 nTPM (protected, limit 3); salivary gland: 29.5 nTPM (protected, limit 4); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (manageable, limit 10); hypothalamus: 26.1 nTPM (vital, limit 1); skin: 23.6 nTPM (manageable, limit 5); pancreas: 23.3 nTPM (vital, limit 2); small intestine: 23.2 nTPM (vital, limit 2); esophagus: 21.8 nTPM (protected, limit 3); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 4); thymus: 18.4 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 10); smooth muscle: 17.6 nTPM (vital, limit 2); lymph node: 17.5 nTPM (protected, limit 4); urinary bladder: 17.4 nTPM (protected, limit 4); colon: 17.3 nTPM (protected, limit 3); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 2); cerebellum: 10.1 nTPM (vital, limit 2)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205707,ETFRF1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 54.9296% (minimum 70%, Approved); amygdala: 63.1214% (minimum 75%, Missing); basal ganglia: 65.4676% (minimum 75%, Missing); cerebral cortex: 64.0094% (minimum 70%, Approved); duodenum: 62.6866% (minimum 70%, Approved); heart muscle: 51.6068% (minimum 75%, Missing); hippocampal formation: 63.5623% (minimum 75%, Missing); hypothalamus: 67.6580% (minimum 75%, Missing); kidney: 50.3690% (minimum 70%, Approved); liver: 31.7073% (minimum 70%, Approved); lung: 72.2222% (minimum 75%, Missing); midbrain: 58.5837% (minimum 75%, Missing); parathyroid gland: 60.2649% (minimum 65%, Approved); retina: 64.9227% (minimum 75%, Missing); salivary gland: 64.9227% (minimum 65%, Approved); skeletal muscle: 38.8612% (minimum 75%, Missing); spinal cord: 43.7150% (minimum 75%, Missing); stomach: 64.9227% (minimum 70%, Missing); thyroid gland: 56.5803% (minimum 60%, Approved); tongue: 35.8739% (minimum 70%, Missing)",-0.0341969,-0.341261,-0.382927,0,3,partial,117.6,97.6,41.9,"liver: 117.6 nTPM (vital, limit 2); tongue: 97.6 nTPM (protected, limit 3); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 2); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 2); thyroid gland: 41.9 nTPM (manageable, limit 10); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 4); duodenum: 32.5 nTPM (vital, limit 2); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 2); stomach: 29.5 nTPM (protected, limit 3); salivary gland: 29.5 nTPM (protected, limit 4); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (manageable, limit 10); hypothalamus: 26.1 nTPM (vital, limit 1); skin: 23.6 nTPM (manageable, limit 5); pancreas: 23.3 nTPM (vital, limit 2); small intestine: 23.2 nTPM (vital, limit 2); esophagus: 21.8 nTPM (protected, limit 3); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 4); thymus: 18.4 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 10); smooth muscle: 17.6 nTPM (vital, limit 2); lymph node: 17.5 nTPM (protected, limit 4); urinary bladder: 17.4 nTPM (protected, limit 4); colon: 17.3 nTPM (protected, limit 3); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 2); cerebellum: 10.1 nTPM (vital, limit 2)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205707,ETFRF1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 54.9296% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.1214% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.4676% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.0094% (minimum 75%, Baseline (adaptation disabled)); duodenum: 62.6866% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 51.6068% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.5623% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.6580% (minimum 75%, Baseline (adaptation disabled)); kidney: 50.3690% (minimum 75%, Baseline (adaptation disabled)); liver: 31.7073% (minimum 75%, Baseline (adaptation disabled)); lung: 72.2222% (minimum 75%, Baseline (adaptation disabled)); midbrain: 58.5837% (minimum 75%, Baseline (adaptation disabled)); pancreas: 70.0899% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.2649% (minimum 70%, Baseline (adaptation disabled)); retina: 64.9227% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.9227% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 38.8612% (minimum 75%, Baseline (adaptation disabled)); small intestine: 70.1799% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 43.7150% (minimum 75%, Baseline (adaptation disabled)); stomach: 64.9227% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 56.5803% (minimum 65%, Baseline (adaptation disabled)); tongue: 35.8739% (minimum 70%, Baseline (adaptation disabled))",-0.0841969,-0.341261,-0.432927,0,3,partial,117.6,97.6,41.9,"liver: 117.6 nTPM (vital, limit 1); tongue: 97.6 nTPM (protected, limit 3); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 1); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 1); thyroid gland: 41.9 nTPM (manageable, limit 5); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 3); duodenum: 32.5 nTPM (vital, limit 1); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 3); salivary gland: 29.5 nTPM (protected, limit 3); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (manageable, limit 5); hypothalamus: 26.1 nTPM (vital, limit 1); skin: 23.6 nTPM (manageable, limit 5); pancreas: 23.3 nTPM (vital, limit 1); small intestine: 23.2 nTPM (vital, limit 1); esophagus: 21.8 nTPM (protected, limit 3); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 3); thymus: 18.4 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); smooth muscle: 17.6 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 3); urinary bladder: 17.4 nTPM (protected, limit 3); colon: 17.3 nTPM (protected, limit 3); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205707,ETFRF1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205718,MBD3L4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205718,MBD3L4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205718,MBD3L4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205718,MBD3L4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205718,MBD3L4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 78.2609% (minimum 99%, Missing)",0.05,0.03,-0.207391,0,4,partial,0.5,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205777,GAGE1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.0326087,0,4,partial,0.5,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205777,GAGE1,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.0326087,0,4,partial,0.5,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205777,GAGE1,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.0326087,0,4,partial,0.5,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205777,GAGE1,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.0326087,0,4,partial,0.5,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205777,GAGE1,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.1602% (minimum 99%, Missing); choroid plexus: 97.0588% (minimum 99%, Missing); lung: 97.0588% (minimum 99%, Missing); lymph node: 90.6593% (minimum 97%, Missing); midbrain: 98.8024% (minimum 99%, Missing); small intestine: 94.8276% (minimum 99%, Missing); spinal cord: 98.2143% (minimum 99%, Missing); spleen: 88.7097% (minimum 95%, Missing); thymus: 91.1602% (minimum 95%, Missing)",-0.0629032,-0.0634066,-0.0783978,0,80,unavailable,1.6,1.7,2.1,"bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205784,ARRDC5,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.237097,0.206593,0.161602,0,80,unavailable,1.6,1.7,2.1,"bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205784,ARRDC5,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.237097,0.206593,0.161602,0,80,unavailable,1.6,1.7,2.1,"bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205784,ARRDC5,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.237097,0.206593,0.161602,0,80,unavailable,1.6,1.7,2.1,"bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205784,ARRDC5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.237097,0.206593,0.161602,0,80,unavailable,1.6,1.7,2.1,"bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205784,ARRDC5,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 96.2264% (minimum 99%, Missing); basal ganglia: 95.3271% (minimum 99%, Missing); cerebellum: 98.0769% (minimum 99%, Missing); cerebral cortex: 96.2264% (minimum 99%, Missing); hippocampal formation: 96.2264% (minimum 99%, Missing); hypothalamus: 96.2264% (minimum 99%, Missing); liver: 97.1429% (minimum 99%, Missing); midbrain: 95.3271% (minimum 99%, Missing); pancreas: 96.2264% (minimum 99%, Missing); pituitary gland: 98.0769% (minimum 99%, Missing); retina: 96.2264% (minimum 99%, Missing); spinal cord: 94.4444% (minimum 99%, Missing)",0.0214286,0.0202913,-0.0455556,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205832,C16orf96,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.321429,0.290291,0.194444,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205832,C16orf96,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.321429,0.290291,0.194444,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205832,C16orf96,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.321429,0.290291,0.194444,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205832,C16orf96,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.321429,0.290291,0.194444,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205832,C16orf96,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.7342% (minimum 99%, Missing); choroid plexus: 72.8972% (minimum 99%, Missing); heart muscle: 98.7342% (minimum 99%, Missing); hippocampal formation: 98.7342% (minimum 99%, Missing); hypothalamus: 95.1220% (minimum 99%, Missing); kidney: 81.2500% (minimum 99%, Missing); liver: 66.1017% (minimum 99%, Missing); pancreas: 95.1220% (minimum 99%, Missing); retina: 96.2963% (minimum 99%, Missing); smooth muscle: 92.8571% (minimum 99%, Missing)",0.05,0.03,-0.328983,0,80,unavailable,4,0,0,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205835,GMNC,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 72.8972% (minimum 75%, Missing); liver: 66.1017% (minimum 75%, Missing)",0.35,0.3,-0.0889831,0,80,unavailable,4,0,0,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205835,GMNC,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 72.8972% (minimum 75%, Missing); liver: 66.1017% (minimum 75%, Missing)",0.35,0.3,-0.0889831,0,80,unavailable,4,0,0,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205835,GMNC,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 72.8972% (minimum 75%, Missing); liver: 66.1017% (minimum 75%, Missing)",0.35,0.3,-0.0889831,0,80,unavailable,4,0,0,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205835,GMNC,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 72.8972% (minimum 75%, Baseline (adaptation disabled)); liver: 66.1017% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.0889831,0,80,unavailable,4,0,0,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205835,GMNC,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 97.6959% (minimum 99%, Missing); choroid plexus: 94.2222% (minimum 99%, Missing); hippocampal formation: 98.1481% (minimum 99%, Missing); hypothalamus: 97.6959% (minimum 99%, Missing); pituitary gland: 96.3636% (minimum 99%, Missing); retina: 93.8053% (minimum 99%, Missing)",0.0406542,0.03,-0.0519469,0,2,partial,1.4,0.8,0.9,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205838,TTC23L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340654,0.3,0.188053,0,2,partial,1.4,0.8,0.9,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205838,TTC23L,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340654,0.3,0.188053,0,2,partial,1.4,0.8,0.9,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205838,TTC23L,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340654,0.3,0.188053,0,2,partial,1.4,0.8,0.9,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205838,TTC23L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.309276,0.263636,0.188053,0,2,partial,1.4,0.8,0.9,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205838,TTC23L,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 52.5510% (minimum 99%, Missing); midbrain: 94.4954% (minimum 99%, Missing); pituitary gland: 92.7928% (minimum 99%, Missing); spinal cord: 98.0952% (minimum 99%, Missing)",0.05,0.03,-0.46449,0,3,partial,9.3,0.3,0,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205856,C22orf42,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 52.5510% (minimum 75%, Missing)",0.35,0.3,-0.22449,0,3,partial,9.3,0.3,0,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205856,C22orf42,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 52.5510% (minimum 75%, Missing)",0.35,0.3,-0.22449,0,3,partial,9.3,0.3,0,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205856,C22orf42,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 52.5510% (minimum 75%, Missing)",0.35,0.3,-0.22449,0,3,partial,9.3,0.3,0,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205856,C22orf42,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 52.5510% (minimum 75%, Baseline (adaptation disabled))",0.35,0.271698,-0.22449,0,3,partial,9.3,0.3,0,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205856,C22orf42,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205858,LRRC72,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205858,LRRC72,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205858,LRRC72,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205858,LRRC72,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205858,LRRC72,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.7903% (minimum 99%, Missing); pancreas: 98.0000% (minimum 99%, Missing); pituitary gland: 98.7903% (minimum 99%, Missing)",0.05,0.0179032,-0.01,0,80,unavailable,0.5,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205882,DEFB134,admission_only,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.287903,0.23,0,80,unavailable,0.5,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205882,DEFB134,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.287903,0.23,0,80,unavailable,0.5,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205882,DEFB134,grid_revised,True,False,True,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.287903,0.23,0,80,unavailable,0.5,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205882,DEFB134,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.287903,0.23,0,80,unavailable,0.5,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205882,DEFB134,current_fixed,True,False,True,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.00819495,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205883,DEFB135,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.248195,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205883,DEFB135,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.248195,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205883,DEFB135,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.248195,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205883,DEFB135,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.248195,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000205883,DEFB135,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 30.7692% (minimum 95%, Approved)",0.05,-0.642308,0.01,0,1,partial,0.1,25.2,0.4,"stomach: 25.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205916,DAZ4,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 30.7692% (minimum 65%, Approved)",0.35,-0.342308,0.25,0,1,partial,0.1,25.2,0.4,"stomach: 25.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205916,DAZ4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 30.7692% (minimum 65%, Approved)",0.35,-0.342308,0.25,0,1,partial,0.1,25.2,0.4,"stomach: 25.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205916,DAZ4,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 30.7692% (minimum 65%, Approved)",0.35,-0.342308,0.25,0,1,partial,0.1,25.2,0.4,"stomach: 25.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205916,DAZ4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 30.7692% (minimum 70%, Baseline (adaptation disabled))",0.315517,-0.392308,0.24115,0,1,partial,0.1,25.2,0.4,"stomach: 25.2 nTPM (protected, limit 3)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205916,DAZ4,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 35.8025% (minimum 95%, Approved)",0.0354839,-0.591975,0.01,0,1,partial,0,5.2,0.2,"stomach: 5.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205944,DAZ2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 35.8025% (minimum 65%, Approved)",0.335484,-0.291975,0.25,0,1,partial,0,5.2,0.2,"stomach: 5.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205944,DAZ2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 35.8025% (minimum 65%, Approved)",0.335484,-0.291975,0.25,0,1,partial,0,5.2,0.2,"stomach: 5.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205944,DAZ2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 35.8025% (minimum 65%, Approved)",0.335484,-0.291975,0.25,0,1,partial,0,5.2,0.2,"stomach: 5.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205944,DAZ2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 35.8025% (minimum 70%, Baseline (adaptation disabled))",0.285484,-0.341975,0.25,0,1,partial,0,5.2,0.2,"stomach: 5.2 nTPM (protected, limit 3)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000205944,DAZ2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206026,SMIM21,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206026,SMIM21,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206026,SMIM21,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206026,SMIM21,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206026,SMIM21,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206043,C18orf63,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206043,C18orf63,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206043,C18orf63,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206043,C18orf63,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206043,C18orf63,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.8235% (minimum 90%, Approved); adrenal gland: 90.4762% (minimum 99%, Missing); amygdala: 25.9091% (minimum 99%, Missing); basal ganglia: 44.8819% (minimum 99%, Missing); cerebellum: 52.7778% (minimum 99%, Missing); cerebral cortex: 24.3590% (minimum 99%, Missing); choroid plexus: 89.0625% (minimum 99%, Missing); colon: 90.4762% (minimum 97%, Missing); duodenum: 95.0000% (minimum 98%, Approved); esophagus: 89.0625% (minimum 95%, Approved); heart muscle: 48.7179% (minimum 99%, Missing); hippocampal formation: 30.1587% (minimum 99%, Missing); hypothalamus: 44.5312% (minimum 99%, Missing); kidney: 54.8077% (minimum 99%, Missing); liver: 71.2500% (minimum 98%, Approved); lung: 71.2500% (minimum 99%, Missing); lymph node: 91.9355% (minimum 97%, Missing); midbrain: 38.2550% (minimum 99%, Missing); pancreas: 96.6102% (minimum 98%, Approved); parathyroid gland: 32.0225% (minimum 95%, Approved); pituitary gland: 90.4762% (minimum 99%, Missing); rectum: 91.9355% (minimum 95%, Approved); retina: 20.8791% (minimum 99%, Missing); salivary gland: 87.6923% (minimum 95%, Approved); skin: 93.4426% (minimum 95%, Missing); small intestine: 91.9355% (minimum 98%, Approved); smooth muscle: 70.3704% (minimum 98%, Approved); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 86.3636% (minimum 95%, Missing); stomach: 89.0625% (minimum 95%, Approved); thyroid gland: 72.1519% (minimum 90%, Approved); tongue: 91.9355% (minimum 97%, Missing); urinary bladder: 65.5172% (minimum 95%, Approved)",-0.178481,-0.629775,-0.781209,0,0,routine_complete,21.6,12.1,2.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 4); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 2); liver: 2.3 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206052,DOK6,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 25.9091% (minimum 75%, Missing); basal ganglia: 44.8819% (minimum 75%, Missing); cerebellum: 52.7778% (minimum 75%, Missing); cerebral cortex: 24.3590% (minimum 75%, Missing); heart muscle: 48.7179% (minimum 75%, Missing); hippocampal formation: 30.1587% (minimum 75%, Missing); hypothalamus: 44.5312% (minimum 75%, Missing); kidney: 54.8077% (minimum 75%, Missing); lung: 71.2500% (minimum 75%, Missing); midbrain: 38.2550% (minimum 75%, Missing); parathyroid gland: 32.0225% (minimum 65%, Approved); retina: 20.8791% (minimum 75%, Missing)",0.121519,-0.329775,-0.541209,0,0,routine_complete,21.6,12.1,2.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 4); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 2); liver: 2.3 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206052,DOK6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 25.9091% (minimum 75%, Missing); basal ganglia: 44.8819% (minimum 75%, Missing); cerebellum: 52.7778% (minimum 75%, Missing); cerebral cortex: 24.3590% (minimum 75%, Missing); heart muscle: 48.7179% (minimum 75%, Missing); hippocampal formation: 30.1587% (minimum 75%, Missing); hypothalamus: 44.5312% (minimum 75%, Missing); kidney: 54.8077% (minimum 75%, Missing); lung: 71.2500% (minimum 75%, Missing); midbrain: 38.2550% (minimum 75%, Missing); parathyroid gland: 32.0225% (minimum 65%, Approved); retina: 20.8791% (minimum 75%, Missing)",0.121519,-0.329775,-0.541209,0,0,routine_complete,21.6,12.1,2.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 4); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 2); liver: 2.3 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206052,DOK6,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 25.9091% (minimum 75%, Missing); basal ganglia: 44.8819% (minimum 75%, Missing); cerebellum: 52.7778% (minimum 75%, Missing); cerebral cortex: 24.3590% (minimum 75%, Missing); heart muscle: 48.7179% (minimum 75%, Missing); hippocampal formation: 30.1587% (minimum 75%, Missing); hypothalamus: 44.5312% (minimum 75%, Missing); kidney: 54.8077% (minimum 75%, Missing); lung: 71.2500% (minimum 75%, Missing); midbrain: 38.2550% (minimum 75%, Missing); parathyroid gland: 32.0225% (minimum 65%, Approved); retina: 20.8791% (minimum 75%, Missing)",0.121519,-0.329775,-0.541209,0,0,routine_complete,21.6,12.1,2.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 4); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 2); liver: 2.3 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206052,DOK6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 25.9091% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 44.8819% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 52.7778% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 24.3590% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 48.7179% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 30.1587% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 44.5312% (minimum 75%, Baseline (adaptation disabled)); kidney: 54.8077% (minimum 75%, Baseline (adaptation disabled)); liver: 71.2500% (minimum 75%, Baseline (adaptation disabled)); lung: 71.2500% (minimum 75%, Baseline (adaptation disabled)); midbrain: 38.2550% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 32.0225% (minimum 70%, Baseline (adaptation disabled)); retina: 20.8791% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.3704% (minimum 75%, Baseline (adaptation disabled)); urinary bladder: 65.5172% (minimum 70%, Baseline (adaptation disabled))",0.071519,-0.379775,-0.541209,0,0,routine_complete,21.6,12.1,2.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 3); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206052,DOK6,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing)",-0.15,0.03,-0.323333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000206102,KRTAP19-8,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.3,-0.0833333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000206102,KRTAP19-8,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.3,-0.0833333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000206102,KRTAP19-8,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.3,-0.0833333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000206102,KRTAP19-8,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.15,0.3,-0.0833333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000206102,KRTAP19-8,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 87.9310% (minimum 99%, Missing); amygdala: 96.2264% (minimum 99%, Missing); basal ganglia: 92.7273% (minimum 99%, Missing); cerebellum: 94.4444% (minimum 99%, Missing); cerebral cortex: 98.0769% (minimum 99%, Missing); choroid plexus: 67.1053% (minimum 99%, Missing); hippocampal formation: 92.7273% (minimum 99%, Missing); hypothalamus: 91.0714% (minimum 99%, Missing); kidney: 96.2264% (minimum 99%, Missing); liver: 98.0769% (minimum 99%, Missing); lung: 89.4737% (minimum 99%, Missing); pancreas: 94.4444% (minimum 99%, Missing); pituitary gland: 87.9310% (minimum 99%, Missing); retina: 78.4615% (minimum 99%, Missing); spinal cord: 98.0769% (minimum 99%, Missing)",0.0122642,0.0107692,-0.318947,0,80,unavailable,2.5,0.1,0.2,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206113,CFAP99,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 67.1053% (minimum 75%, Missing)",0.312264,0.280769,-0.0789474,0,80,unavailable,2.5,0.1,0.2,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206113,CFAP99,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 67.1053% (minimum 75%, Missing)",0.312264,0.280769,-0.0789474,0,80,unavailable,2.5,0.1,0.2,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206113,CFAP99,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 67.1053% (minimum 75%, Missing)",0.312264,0.280769,-0.0789474,0,80,unavailable,2.5,0.1,0.2,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206113,CFAP99,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 67.1053% (minimum 75%, Baseline (adaptation disabled))",0.312264,0.280769,-0.0789474,0,80,unavailable,2.5,0.1,0.2,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206113,CFAP99,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0483339,0.0204132,0.00733688,0,80,unavailable,0.8,2.9,0.5,"salivary gland: 2.9 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206150,RNASE13,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348334,0.290413,0.247337,0,80,unavailable,0.8,2.9,0.5,"salivary gland: 2.9 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206150,RNASE13,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.348334,0.290413,0.247337,0,80,unavailable,0.8,2.9,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206150,RNASE13,grid_revised,True,False,True,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.348334,0.290413,0.247337,0,80,unavailable,0.8,2.9,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206150,RNASE13,current_adaptive,True,False,True,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.348334,0.290413,0.247337,0,80,unavailable,0.8,2.9,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206150,RNASE13,current_fixed,True,False,True,False,10.1038/ncomms10499,Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / germinal center cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206181,ELOA2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / germinal center cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206181,ELOA2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / germinal center cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206181,ELOA2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / germinal center cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206181,ELOA2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / germinal center cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206181,ELOA2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0492436,0.03,0.00622926,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000206203,TSSK2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.349244,0.3,0.246229,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000206203,TSSK2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.349244,0.3,0.246229,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000206203,TSSK2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.349244,0.3,0.246229,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000206203,TSSK2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.349244,0.3,0.246229,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000206203,TSSK2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 93.7500% (minimum 99%, Missing)",0.05,0.03,-0.0525,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206260,PRR23A,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206260,PRR23A,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206260,PRR23A,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206260,PRR23A,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.1875,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206260,PRR23A,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 80.4878% (minimum 95%, Uncertain); adrenal gland: 85.7143% (minimum 99%, Uncertain); amygdala: 89.1892% (minimum 99%, Missing); basal ganglia: 84.6154% (minimum 99%, Missing); bone marrow: 89.1892% (minimum 99%, Uncertain); cerebellum: 70.9677% (minimum 99%, Uncertain); cerebral cortex: 86.8421% (minimum 99%, Missing); choroid plexus: 52.8000% (minimum 99%, Missing); colon: 71.7391% (minimum 97%, Uncertain); duodenum: 90.4110% (minimum 99%, Uncertain); esophagus: 80.4878% (minimum 97%, Uncertain); heart muscle: 80.4878% (minimum 99%, Uncertain); hippocampal formation: 84.6154% (minimum 99%, Missing); hypothalamus: 83.5443% (minimum 99%, Missing); kidney: 78.5714% (minimum 99%, Uncertain); liver: 76.7442% (minimum 99%, Uncertain); lung: 73.3333% (minimum 99%, Uncertain); lymph node: 84.6154% (minimum 97%, Uncertain); midbrain: 92.9577% (minimum 99%, Missing); pancreas: 64.7059% (minimum 99%, Uncertain); parathyroid gland: 77.6471% (minimum 97%, Uncertain); pituitary gland: 51.9685% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Uncertain); retina: 44.0000% (minimum 99%, Missing); salivary gland: 57.8947% (minimum 97%, Uncertain); skeletal muscle: 83.5443% (minimum 99%, Uncertain); skin: 74.1573% (minimum 95%, Missing); small intestine: 70.2128% (minimum 99%, Uncertain); smooth muscle: 90.4110% (minimum 99%, Uncertain); spinal cord: 89.1892% (minimum 99%, Missing); spleen: 77.6471% (minimum 95%, Missing); stomach: 69.4737% (minimum 97%, Uncertain); thymus: 82.5000% (minimum 95%, Missing); thyroid gland: 68.0412% (minimum 95%, Uncertain); tongue: 95.6522% (minimum 97%, Missing); urinary bladder: 74.1573% (minimum 97%, Uncertain)",-0.269588,-0.391053,-0.55,0,1,partial,8.4,4.8,3.1,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); pancreas: 3.6 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206530,CFAP44,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 70.9677% (minimum 75%, Uncertain); choroid plexus: 52.8000% (minimum 75%, Missing); lung: 73.3333% (minimum 75%, Uncertain); pancreas: 64.7059% (minimum 75%, Uncertain); pituitary gland: 51.9685% (minimum 75%, Missing); retina: 44.0000% (minimum 75%, Missing); salivary gland: 57.8947% (minimum 70%, Uncertain); small intestine: 70.2128% (minimum 75%, Uncertain); stomach: 69.4737% (minimum 70%, Uncertain)",0.0304124,-0.121053,-0.31,0,1,partial,8.4,4.8,3.1,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); pancreas: 3.6 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206530,CFAP44,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 70.9677% (minimum 75%, Uncertain); choroid plexus: 52.8000% (minimum 75%, Missing); lung: 73.3333% (minimum 75%, Uncertain); pancreas: 64.7059% (minimum 75%, Uncertain); pituitary gland: 51.9685% (minimum 75%, Missing); retina: 44.0000% (minimum 75%, Missing); salivary gland: 57.8947% (minimum 70%, Uncertain); small intestine: 70.2128% (minimum 75%, Uncertain); stomach: 69.4737% (minimum 70%, Uncertain)",0.0304124,-0.121053,-0.31,0,1,partial,8.4,4.8,3.1,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); pancreas: 3.6 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206530,CFAP44,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 70.9677% (minimum 75%, Uncertain); choroid plexus: 52.8000% (minimum 75%, Missing); lung: 73.3333% (minimum 75%, Uncertain); pancreas: 64.7059% (minimum 75%, Uncertain); pituitary gland: 51.9685% (minimum 75%, Missing); retina: 44.0000% (minimum 75%, Missing); salivary gland: 57.8947% (minimum 70%, Uncertain); small intestine: 70.2128% (minimum 75%, Uncertain); stomach: 69.4737% (minimum 70%, Uncertain)",0.0304124,-0.121053,-0.31,0,1,partial,8.4,4.8,3.1,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); pancreas: 3.6 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206530,CFAP44,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 70.9677% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 52.8000% (minimum 75%, Baseline (adaptation disabled)); lung: 73.3333% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.7059% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 51.9685% (minimum 75%, Baseline (adaptation disabled)); retina: 44.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 57.8947% (minimum 70%, Baseline (adaptation disabled)); small intestine: 70.2128% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.4737% (minimum 70%, Baseline (adaptation disabled))",0.0304124,-0.121053,-0.31,0,1,partial,8.4,4.8,3.1,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); pancreas: 3.6 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206530,CFAP44,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206531,CD200R1L,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206531,CD200R1L,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206531,CD200R1L,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206531,CD200R1L,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206531,CD200R1L,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 94.0000% (minimum 99%, Missing); basal ganglia: 87.0370% (minimum 99%, Missing); bone marrow: 95.9184% (minimum 99%, Missing); cerebral cortex: 94.0000% (minimum 99%, Missing); hippocampal formation: 95.9184% (minimum 99%, Missing); hypothalamus: 94.0000% (minimum 99%, Missing); kidney: 85.4545% (minimum 99%, Missing); lung: 87.0370% (minimum 99%, Missing); pituitary gland: 95.9184% (minimum 99%, Missing); retina: 94.0000% (minimum 99%, Missing)",0.05,0.03,-0.135455,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206557,TRIM71,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.104545,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206557,TRIM71,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.104545,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206557,TRIM71,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.104545,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206557,TRIM71,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.104545,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000206557,TRIM71,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00808429,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212122,TSSK1B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248084,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212122,TSSK1B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248084,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212122,TSSK1B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248084,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212122,TSSK1B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346176,0.3,0.248084,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212122,TSSK1B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.9318% (minimum 95%, Enhanced); amygdala: 94.0154% (minimum 99%, Missing); basal ganglia: 92.0605% (minimum 99%, Missing); cerebellum: 94.5631% (minimum 95%, Enhanced); cerebral cortex: 93.2950% (minimum 95%, Enhanced); choroid plexus: 97.7912% (minimum 99%, Missing); colon: 92.7619% (minimum 97%, Missing); hippocampal formation: 93.2950% (minimum 99%, Missing); hypothalamus: 94.7471% (minimum 99%, Missing); kidney: 87.5899% (minimum 95%, Enhanced); liver: 80.7629% (minimum 95%, Enhanced); midbrain: 95.1172% (minimum 99%, Missing); pancreas: 88.8686% (minimum 99%, Missing); pituitary gland: 92.9389% (minimum 99%, Missing); retina: 98.5830% (minimum 99%, Missing); small intestine: 89.5221% (minimum 95%, Enhanced); spinal cord: 94.5631% (minimum 99%, Missing)",0.0338384,-0.042381,-0.142371,0,5,partial,11.6,4.9,6.3,"liver: 11.6 nTPM (vital, limit 6); kidney: 6.9 nTPM (vital, limit 6); pancreas: 6.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); pituitary gland: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212123,PRR22,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333838,0.227619,0.138686,0,5,partial,11.6,4.9,6.3,"liver: 11.6 nTPM (vital, limit 6); kidney: 6.9 nTPM (vital, limit 6); pancreas: 6.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); pituitary gland: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212123,PRR22,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333838,0.227619,0.138686,0,5,partial,11.6,4.9,6.3,"liver: 11.6 nTPM (vital, limit 6); kidney: 6.9 nTPM (vital, limit 6); pancreas: 6.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); pituitary gland: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212123,PRR22,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333838,0.227619,0.138686,0,5,partial,11.6,4.9,6.3,"liver: 11.6 nTPM (vital, limit 6); kidney: 6.9 nTPM (vital, limit 6); pancreas: 6.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); pituitary gland: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212123,PRR22,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.235455,0.208582,0.0576285,0,5,partial,11.6,4.9,6.3,"liver: 11.6 nTPM (vital, limit 1); kidney: 6.9 nTPM (vital, limit 1); spleen: 6.3 nTPM (manageable, limit 5); pancreas: 6.1 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 4.9 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 3); colon: 3.8 nTPM (protected, limit 3); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212123,PRR22,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212710,CTAGE1,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212710,CTAGE1,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212710,CTAGE1,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212710,CTAGE1,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212710,CTAGE1,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.2857% (minimum 90%, Approved); adrenal gland: 76.4706% (minimum 99%, Missing); amygdala: 78.7879% (minimum 99%, Missing); basal ganglia: 68.4211% (minimum 99%, Missing); bone marrow: 81.2500% (minimum 99%, Missing); cerebellum: 76.4706% (minimum 99%, Missing); cerebral cortex: 55.3191% (minimum 99%, Missing); choroid plexus: 96.2963% (minimum 99%, Missing); colon: 76.4706% (minimum 97%, Missing); duodenum: 70.2703% (minimum 99%, Missing); esophagus: 86.6667% (minimum 97%, Missing); heart muscle: 55.3191% (minimum 99%, Missing); hippocampal formation: 76.4706% (minimum 99%, Missing); hypothalamus: 74.2857% (minimum 99%, Missing); kidney: 74.2857% (minimum 99%, Missing); liver: 54.1667% (minimum 98%, Approved); lung: 72.2222% (minimum 99%, Missing); lymph node: 54.1667% (minimum 97%, Missing); midbrain: 81.2500% (minimum 99%, Missing); pancreas: 60.4651% (minimum 99%, Missing); parathyroid gland: 81.2500% (minimum 97%, Missing); pituitary gland: 78.7879% (minimum 99%, Missing); rectum: 78.7879% (minimum 97%, Missing); retina: 48.1481% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 55.3191% (minimum 99%, Missing); skin: 89.6552% (minimum 95%, Missing); small intestine: 63.4146% (minimum 99%, Missing); smooth muscle: 72.2222% (minimum 99%, Missing); spinal cord: 81.2500% (minimum 99%, Missing); spleen: 68.4211% (minimum 90%, Approved); stomach: 66.6667% (minimum 97%, Missing); thymus: 45.6140% (minimum 95%, Missing); thyroid gland: 59.0909% (minimum 95%, Missing); tongue: 68.4211% (minimum 97%, Missing); urinary bladder: 76.4706% (minimum 97%, Missing)",-0.49386,-0.428333,-0.508519,0,2,partial,2.8,2.2,3.1,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 2); lymph node: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212916,MAP10,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 68.4211% (minimum 75%, Missing); cerebral cortex: 55.3191% (minimum 75%, Missing); duodenum: 70.2703% (minimum 75%, Missing); heart muscle: 55.3191% (minimum 75%, Missing); hypothalamus: 74.2857% (minimum 75%, Missing); kidney: 74.2857% (minimum 75%, Missing); liver: 54.1667% (minimum 70%, Approved); lung: 72.2222% (minimum 75%, Missing); lymph node: 54.1667% (minimum 70%, Missing); pancreas: 60.4651% (minimum 75%, Missing); retina: 48.1481% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 55.3191% (minimum 75%, Missing); small intestine: 63.4146% (minimum 75%, Missing); smooth muscle: 72.2222% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing); thymus: 45.6140% (minimum 65%, Missing); thyroid gland: 59.0909% (minimum 65%, Missing); tongue: 68.4211% (minimum 70%, Missing)",-0.19386,-0.158333,-0.268519,0,2,partial,2.8,2.2,3.1,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 2); lymph node: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212916,MAP10,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 68.4211% (minimum 75%, Missing); cerebral cortex: 55.3191% (minimum 75%, Missing); duodenum: 70.2703% (minimum 75%, Missing); heart muscle: 55.3191% (minimum 75%, Missing); hypothalamus: 74.2857% (minimum 75%, Missing); kidney: 74.2857% (minimum 75%, Missing); liver: 54.1667% (minimum 70%, Approved); lung: 72.2222% (minimum 75%, Missing); lymph node: 54.1667% (minimum 70%, Missing); pancreas: 60.4651% (minimum 75%, Missing); retina: 48.1481% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 55.3191% (minimum 75%, Missing); small intestine: 63.4146% (minimum 75%, Missing); smooth muscle: 72.2222% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing); thymus: 45.6140% (minimum 65%, Missing); thyroid gland: 59.0909% (minimum 65%, Missing); tongue: 68.4211% (minimum 70%, Missing)",-0.19386,-0.158333,-0.268519,0,2,partial,2.8,2.2,3.1,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212916,MAP10,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 68.4211% (minimum 75%, Missing); cerebral cortex: 55.3191% (minimum 75%, Missing); duodenum: 70.2703% (minimum 75%, Missing); heart muscle: 55.3191% (minimum 75%, Missing); hypothalamus: 74.2857% (minimum 75%, Missing); kidney: 74.2857% (minimum 75%, Missing); liver: 54.1667% (minimum 70%, Approved); lung: 72.2222% (minimum 75%, Missing); lymph node: 54.1667% (minimum 70%, Missing); pancreas: 60.4651% (minimum 75%, Missing); retina: 48.1481% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 55.3191% (minimum 75%, Missing); small intestine: 63.4146% (minimum 75%, Missing); smooth muscle: 72.2222% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing); thymus: 45.6140% (minimum 65%, Missing); thyroid gland: 59.0909% (minimum 65%, Missing); tongue: 68.4211% (minimum 70%, Missing)",-0.19386,-0.158333,-0.268519,0,2,partial,2.8,2.2,3.1,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212916,MAP10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 68.4211% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 55.3191% (minimum 75%, Baseline (adaptation disabled)); duodenum: 70.2703% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 55.3191% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.2857% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.2857% (minimum 75%, Baseline (adaptation disabled)); liver: 54.1667% (minimum 75%, Baseline (adaptation disabled)); lung: 72.2222% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.1667% (minimum 70%, Baseline (adaptation disabled)); pancreas: 60.4651% (minimum 75%, Baseline (adaptation disabled)); retina: 48.1481% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 55.3191% (minimum 75%, Baseline (adaptation disabled)); small intestine: 63.4146% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.2222% (minimum 75%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 70%, Baseline (adaptation disabled)); thymus: 45.6140% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 59.0909% (minimum 65%, Baseline (adaptation disabled)); tongue: 68.4211% (minimum 70%, Baseline (adaptation disabled))",-0.19386,-0.158333,-0.268519,0,2,partial,2.8,2.2,3.1,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000212916,MAP10,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000212933,KRTAP12-4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000212933,KRTAP12-4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000212933,KRTAP12-4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000212933,KRTAP12-4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000212933,KRTAP12-4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.7917% (minimum 95%, Missing); adrenal gland: 81.7073% (minimum 99%, Missing); amygdala: 80.7229% (minimum 99%, Missing); basal ganglia: 72.0430% (minimum 99%, Missing); bone marrow: 66.3366% (minimum 99%, Missing); cerebellum: 72.0430% (minimum 99%, Missing); cerebral cortex: 70.5263% (minimum 99%, Missing); choroid plexus: 84.8101% (minimum 99%, Missing); colon: 72.0430% (minimum 97%, Missing); duodenum: 74.4444% (minimum 99%, Missing); esophagus: 81.7073% (minimum 97%, Missing); heart muscle: 70.5263% (minimum 99%, Missing); hippocampal formation: 78.8235% (minimum 99%, Missing); hypothalamus: 77.9070% (minimum 99%, Missing); kidney: 63.8095% (minimum 99%, Missing); liver: 79.7619% (minimum 99%, Missing); lung: 69.7917% (minimum 99%, Missing); lymph node: 66.3366% (minimum 97%, Missing); midbrain: 81.7073% (minimum 99%, Missing); pancreas: 62.0370% (minimum 99%, Missing); parathyroid gland: 70.5263% (minimum 97%, Missing); pituitary gland: 75.2809% (minimum 99%, Missing); rectum: 69.0722% (minimum 97%, Missing); retina: 62.0370% (minimum 99%, Missing); salivary gland: 77.0115% (minimum 97%, Missing); skeletal muscle: 81.7073% (minimum 99%, Missing); skin: 79.7619% (minimum 95%, Missing); small intestine: 77.9070% (minimum 99%, Missing); smooth muscle: 68.3673% (minimum 99%, Missing); spinal cord: 77.9070% (minimum 99%, Missing); spleen: 65.6863% (minimum 95%, Missing); stomach: 72.0430% (minimum 97%, Missing); thymus: 61.4679% (minimum 95%, Missing); thyroid gland: 63.8095% (minimum 95%, Missing); tongue: 78.8235% (minimum 97%, Missing); urinary bladder: 73.6264% (minimum 97%, Missing)",-0.335321,-0.306634,-0.36963,0,80,unavailable,4.1,3.4,4.2,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213020,ZNF611,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 72.0430% (minimum 75%, Missing); bone marrow: 66.3366% (minimum 75%, Missing); cerebellum: 72.0430% (minimum 75%, Missing); cerebral cortex: 70.5263% (minimum 75%, Missing); duodenum: 74.4444% (minimum 75%, Missing); heart muscle: 70.5263% (minimum 75%, Missing); kidney: 63.8095% (minimum 75%, Missing); lung: 69.7917% (minimum 75%, Missing); lymph node: 66.3366% (minimum 70%, Missing); pancreas: 62.0370% (minimum 75%, Missing); rectum: 69.0722% (minimum 70%, Missing); retina: 62.0370% (minimum 75%, Missing); smooth muscle: 68.3673% (minimum 75%, Missing); thymus: 61.4679% (minimum 65%, Missing); thyroid gland: 63.8095% (minimum 65%, Missing)",-0.0353211,-0.0366337,-0.12963,0,80,unavailable,4.1,3.4,4.2,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213020,ZNF611,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 72.0430% (minimum 75%, Missing); bone marrow: 66.3366% (minimum 75%, Missing); cerebellum: 72.0430% (minimum 75%, Missing); cerebral cortex: 70.5263% (minimum 75%, Missing); duodenum: 74.4444% (minimum 75%, Missing); heart muscle: 70.5263% (minimum 75%, Missing); kidney: 63.8095% (minimum 75%, Missing); lung: 69.7917% (minimum 75%, Missing); lymph node: 66.3366% (minimum 70%, Missing); pancreas: 62.0370% (minimum 75%, Missing); rectum: 69.0722% (minimum 70%, Missing); retina: 62.0370% (minimum 75%, Missing); smooth muscle: 68.3673% (minimum 75%, Missing); thymus: 61.4679% (minimum 65%, Missing); thyroid gland: 63.8095% (minimum 65%, Missing)",-0.0353211,-0.0366337,-0.12963,0,80,unavailable,4.1,3.4,4.2,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213020,ZNF611,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 72.0430% (minimum 75%, Missing); bone marrow: 66.3366% (minimum 75%, Missing); cerebellum: 72.0430% (minimum 75%, Missing); cerebral cortex: 70.5263% (minimum 75%, Missing); duodenum: 74.4444% (minimum 75%, Missing); heart muscle: 70.5263% (minimum 75%, Missing); kidney: 63.8095% (minimum 75%, Missing); lung: 69.7917% (minimum 75%, Missing); lymph node: 66.3366% (minimum 70%, Missing); pancreas: 62.0370% (minimum 75%, Missing); rectum: 69.0722% (minimum 70%, Missing); retina: 62.0370% (minimum 75%, Missing); smooth muscle: 68.3673% (minimum 75%, Missing); thymus: 61.4679% (minimum 65%, Missing); thyroid gland: 63.8095% (minimum 65%, Missing)",-0.0353211,-0.0366337,-0.12963,0,80,unavailable,4.1,3.4,4.2,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213020,ZNF611,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 72.0430% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.3366% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.0430% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.5263% (minimum 75%, Baseline (adaptation disabled)); duodenum: 74.4444% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.5263% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.8095% (minimum 75%, Baseline (adaptation disabled)); lung: 69.7917% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.3366% (minimum 70%, Baseline (adaptation disabled)); pancreas: 62.0370% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.0722% (minimum 70%, Baseline (adaptation disabled)); retina: 62.0370% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 68.3673% (minimum 75%, Baseline (adaptation disabled)); thymus: 61.4679% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 63.8095% (minimum 65%, Baseline (adaptation disabled))",-0.0353211,-0.0366337,-0.12963,0,80,unavailable,4.1,3.4,4.2,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213020,ZNF611,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.3433% (minimum 95%, Missing); adrenal gland: 62.7297% (minimum 99%, Missing); amygdala: 79.4020% (minimum 99%, Missing); basal ganglia: 79.1391% (minimum 99%, Missing); bone marrow: 64.8575% (minimum 99%, Missing); cerebellum: 62.9776% (minimum 99%, Missing); cerebral cortex: 76.9726% (minimum 99%, Missing); choroid plexus: 80.6071% (minimum 99%, Missing); colon: 68.7770% (minimum 97%, Missing); duodenum: 67.7054% (minimum 99%, Missing); esophagus: 66.3889% (minimum 97%, Missing); heart muscle: 70.8148% (minimum 99%, Missing); hippocampal formation: 79.0083% (minimum 99%, Missing); hypothalamus: 76.4800% (minimum 99%, Missing); kidney: 72.7549% (minimum 99%, Missing); liver: 60.7370% (minimum 99%, Missing); lung: 72.0965% (minimum 99%, Missing); lymph node: 56.1692% (minimum 97%, Missing); midbrain: 79.5341% (minimum 99%, Missing); pancreas: 70.1909% (minimum 99%, Missing); parathyroid gland: 73.6518% (minimum 97%, Missing); pituitary gland: 68.2857% (minimum 99%, Missing); rectum: 70.7101% (minimum 97%, Missing); retina: 82.9861% (minimum 99%, Missing); salivary gland: 69.3759% (minimum 97%, Missing); skeletal muscle: 59.6010% (minimum 99%, Missing); skin: 67.9943% (minimum 95%, Missing); small intestine: 66.9468% (minimum 99%, Missing); smooth muscle: 64.2473% (minimum 99%, Missing); spinal cord: 76.9726% (minimum 99%, Missing); spleen: 62.4837% (minimum 95%, Missing); stomach: 71.7718% (minimum 97%, Missing); thymus: 54.6286% (minimum 95%, Missing); thyroid gland: 75.1572% (minimum 95%, Missing); tongue: 69.6793% (minimum 97%, Missing); urinary bladder: 67.1348% (minimum 97%, Missing)",-0.403714,-0.408308,-0.39399,0,6,partial,32.4,37.3,39.7,"thymus: 39.7 nTPM (manageable, limit 5); lymph node: 37.3 nTPM (protected, limit 2); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); spleen: 28.7 nTPM (manageable, limit 5); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 2); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 2); duodenum: 22.8 nTPM (vital, limit 1); skin: 22.5 nTPM (manageable, limit 5); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 2); salivary gland: 21.1 nTPM (protected, limit 2); tongue: 20.8 nTPM (protected, limit 2); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 2); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (manageable, limit 5); stomach: 18.8 nTPM (protected, limit 2); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 2); thyroid gland: 15.8 nTPM (manageable, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213024,NUP62,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.7297% (minimum 75%, Missing); bone marrow: 64.8575% (minimum 75%, Missing); cerebellum: 62.9776% (minimum 75%, Missing); colon: 68.7770% (minimum 70%, Missing); duodenum: 67.7054% (minimum 75%, Missing); esophagus: 66.3889% (minimum 70%, Missing); heart muscle: 70.8148% (minimum 75%, Missing); kidney: 72.7549% (minimum 75%, Missing); liver: 60.7370% (minimum 75%, Missing); lung: 72.0965% (minimum 75%, Missing); lymph node: 56.1692% (minimum 70%, Missing); pancreas: 70.1909% (minimum 75%, Missing); pituitary gland: 68.2857% (minimum 75%, Missing); salivary gland: 69.3759% (minimum 70%, Missing); skeletal muscle: 59.6010% (minimum 75%, Missing); small intestine: 66.9468% (minimum 75%, Missing); smooth muscle: 64.2473% (minimum 75%, Missing); spleen: 62.4837% (minimum 65%, Missing); thymus: 54.6286% (minimum 65%, Missing); tongue: 69.6793% (minimum 70%, Missing); urinary bladder: 67.1348% (minimum 70%, Missing)",-0.103714,-0.138308,-0.15399,0,6,partial,32.4,37.3,39.7,"thymus: 39.7 nTPM (manageable, limit 5); lymph node: 37.3 nTPM (protected, limit 2); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); spleen: 28.7 nTPM (manageable, limit 5); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 2); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 2); duodenum: 22.8 nTPM (vital, limit 1); skin: 22.5 nTPM (manageable, limit 5); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 2); salivary gland: 21.1 nTPM (protected, limit 2); tongue: 20.8 nTPM (protected, limit 2); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 2); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (manageable, limit 5); stomach: 18.8 nTPM (protected, limit 2); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 2); thyroid gland: 15.8 nTPM (manageable, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213024,NUP62,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.7297% (minimum 75%, Missing); bone marrow: 64.8575% (minimum 75%, Missing); cerebellum: 62.9776% (minimum 75%, Missing); colon: 68.7770% (minimum 70%, Missing); duodenum: 67.7054% (minimum 75%, Missing); esophagus: 66.3889% (minimum 70%, Missing); heart muscle: 70.8148% (minimum 75%, Missing); kidney: 72.7549% (minimum 75%, Missing); liver: 60.7370% (minimum 75%, Missing); lung: 72.0965% (minimum 75%, Missing); lymph node: 56.1692% (minimum 70%, Missing); pancreas: 70.1909% (minimum 75%, Missing); pituitary gland: 68.2857% (minimum 75%, Missing); salivary gland: 69.3759% (minimum 70%, Missing); skeletal muscle: 59.6010% (minimum 75%, Missing); small intestine: 66.9468% (minimum 75%, Missing); smooth muscle: 64.2473% (minimum 75%, Missing); spleen: 62.4837% (minimum 65%, Missing); thymus: 54.6286% (minimum 65%, Missing); tongue: 69.6793% (minimum 70%, Missing); urinary bladder: 67.1348% (minimum 70%, Missing)",-0.103714,-0.138308,-0.15399,0,6,partial,32.4,37.3,39.7,"thymus: 39.7 nTPM (manageable, limit 5); lymph node: 37.3 nTPM (protected, limit 3); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); spleen: 28.7 nTPM (manageable, limit 5); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 3); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 3); duodenum: 22.8 nTPM (vital, limit 1); skin: 22.5 nTPM (manageable, limit 5); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 3); salivary gland: 21.1 nTPM (protected, limit 3); tongue: 20.8 nTPM (protected, limit 3); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 3); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (manageable, limit 5); stomach: 18.8 nTPM (protected, limit 3); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 3); thyroid gland: 15.8 nTPM (manageable, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213024,NUP62,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.7297% (minimum 75%, Missing); bone marrow: 64.8575% (minimum 75%, Missing); cerebellum: 62.9776% (minimum 75%, Missing); colon: 68.7770% (minimum 70%, Missing); duodenum: 67.7054% (minimum 75%, Missing); esophagus: 66.3889% (minimum 70%, Missing); heart muscle: 70.8148% (minimum 75%, Missing); kidney: 72.7549% (minimum 75%, Missing); liver: 60.7370% (minimum 75%, Missing); lung: 72.0965% (minimum 75%, Missing); lymph node: 56.1692% (minimum 70%, Missing); pancreas: 70.1909% (minimum 75%, Missing); pituitary gland: 68.2857% (minimum 75%, Missing); salivary gland: 69.3759% (minimum 70%, Missing); skeletal muscle: 59.6010% (minimum 75%, Missing); small intestine: 66.9468% (minimum 75%, Missing); smooth muscle: 64.2473% (minimum 75%, Missing); spleen: 62.4837% (minimum 65%, Missing); thymus: 54.6286% (minimum 65%, Missing); tongue: 69.6793% (minimum 70%, Missing); urinary bladder: 67.1348% (minimum 70%, Missing)",-0.103714,-0.138308,-0.15399,0,6,partial,32.4,37.3,39.7,"thymus: 39.7 nTPM (manageable, limit 5); lymph node: 37.3 nTPM (protected, limit 3); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); spleen: 28.7 nTPM (manageable, limit 5); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 3); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 3); duodenum: 22.8 nTPM (vital, limit 1); skin: 22.5 nTPM (manageable, limit 5); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 3); salivary gland: 21.1 nTPM (protected, limit 3); tongue: 20.8 nTPM (protected, limit 3); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 3); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (manageable, limit 5); stomach: 18.8 nTPM (protected, limit 3); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 3); thyroid gland: 15.8 nTPM (manageable, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213024,NUP62,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.7297% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 64.8575% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.9776% (minimum 75%, Baseline (adaptation disabled)); colon: 68.7770% (minimum 70%, Baseline (adaptation disabled)); duodenum: 67.7054% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.3889% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.8148% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.7549% (minimum 75%, Baseline (adaptation disabled)); liver: 60.7370% (minimum 75%, Baseline (adaptation disabled)); lung: 72.0965% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.1692% (minimum 70%, Baseline (adaptation disabled)); pancreas: 70.1909% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 68.2857% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 69.3759% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 59.6010% (minimum 75%, Baseline (adaptation disabled)); small intestine: 66.9468% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.2473% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.4837% (minimum 65%, Baseline (adaptation disabled)); thymus: 54.6286% (minimum 65%, Baseline (adaptation disabled)); tongue: 69.6793% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 67.1348% (minimum 70%, Baseline (adaptation disabled))",-0.103714,-0.138308,-0.15399,0,6,partial,32.4,37.3,39.7,"thymus: 39.7 nTPM (manageable, limit 5); lymph node: 37.3 nTPM (protected, limit 3); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); spleen: 28.7 nTPM (manageable, limit 5); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 3); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 3); duodenum: 22.8 nTPM (vital, limit 1); skin: 22.5 nTPM (manageable, limit 5); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 3); salivary gland: 21.1 nTPM (protected, limit 3); tongue: 20.8 nTPM (protected, limit 3); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 3); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (manageable, limit 5); stomach: 18.8 nTPM (protected, limit 3); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 3); thyroid gland: 15.8 nTPM (manageable, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213024,NUP62,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 88.7255% (minimum 99%, Missing)",0.05,0.03,-0.102745,0,1,partial,2.3,0,0,"pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213030,CGB8,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.137255,0,1,partial,2.3,0,0,"pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213030,CGB8,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.137255,0,1,partial,2.3,0,0,"pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213030,CGB8,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.137255,0,1,partial,2.3,0,0,"pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213030,CGB8,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.137255,0,1,partial,2.3,0,0,"pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213030,CGB8,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.0175% (minimum 95%, Missing); adrenal gland: 90.5660% (minimum 98%, Approved); amygdala: 89.0459% (minimum 99%, Missing); basal ganglia: 87.1595% (minimum 99%, Missing); bone marrow: 87.4241% (minimum 98%, Approved); cerebellum: 96.5055% (minimum 98%, Approved); cerebral cortex: 92.8604% (minimum 99%, Missing); choroid plexus: 81.8182% (minimum 99%, Missing); colon: 60.8145% (minimum 97%, Missing); duodenum: 63.0788% (minimum 99%, Missing); esophagus: 63.5962% (minimum 95%, Approved); heart muscle: 44.2591% (minimum 98%, Approved); hippocampal formation: 87.8049% (minimum 99%, Missing); hypothalamus: 87.3484% (minimum 99%, Missing); kidney: 65.4333% (minimum 99%, Missing); liver: 92.0548% (minimum 98%, Approved); lung: 44.9599% (minimum 99%, Missing); lymph node: 71.1362% (minimum 97%, Missing); midbrain: 86.8217% (minimum 99%, Missing); pancreas: 91.9289% (minimum 98%, Approved); parathyroid gland: 90.7699% (minimum 95%, Approved); pituitary gland: 83.3058% (minimum 99%, Missing); rectum: 79.0278% (minimum 97%, Missing); salivary gland: 60.5042% (minimum 95%, Approved); skeletal muscle: 82.3529% (minimum 98%, Approved); skin: 40.8593% (minimum 95%, Missing); small intestine: 39.9129% (minimum 99%, Missing); smooth muscle: 83.1683% (minimum 99%, Missing); spinal cord: 90.2013% (minimum 99%, Missing); spleen: 68.6181% (minimum 95%, Missing); stomach: 68.7585% (minimum 97%, Missing); thymus: 72.2322% (minimum 95%, Missing); thyroid gland: 53.3051% (minimum 95%, Missing); tongue: 80.7369% (minimum 97%, Missing); urinary bladder: 64.6983% (minimum 95%, Approved)",-0.541407,-0.361855,-0.590871,0,7,partial,303.5,131.6,291.8,"small intestine: 303.5 nTPM (vital, limit 1); skin: 291.8 nTPM (manageable, limit 5); adipose tissue: 256.4 nTPM (manageable, limit 5); heart muscle: 253.9 nTPM (vital, limit 2); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (manageable, limit 5); salivary gland: 131.6 nTPM (protected, limit 4); colon: 129.9 nTPM (protected, limit 2); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 4); urinary bladder: 110 nTPM (protected, limit 4); kidney: 106.5 nTPM (vital, limit 1); spleen: 92.2 nTPM (manageable, limit 5); stomach: 91.6 nTPM (protected, limit 2); lymph node: 81.8 nTPM (protected, limit 2); thymus: 77.5 nTPM (manageable, limit 5); rectum: 53.5 nTPM (protected, limit 2); tongue: 48.1 nTPM (protected, limit 2); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 2); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 2); hippocampal formation: 28 nTPM (vital, limit 1); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 2); parathyroid gland: 20.5 nTPM (protected, limit 4); pancreas: 17.7 nTPM (vital, limit 2); liver: 17.4 nTPM (vital, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213145,CRIP1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.0175% (minimum 65%, Missing); colon: 60.8145% (minimum 70%, Missing); duodenum: 63.0788% (minimum 75%, Missing); esophagus: 63.5962% (minimum 65%, Approved); heart muscle: 44.2591% (minimum 70%, Approved); kidney: 65.4333% (minimum 75%, Missing); lung: 44.9599% (minimum 75%, Missing); salivary gland: 60.5042% (minimum 65%, Approved); skin: 40.8593% (minimum 65%, Missing); small intestine: 39.9129% (minimum 75%, Missing); stomach: 68.7585% (minimum 70%, Missing); thyroid gland: 53.3051% (minimum 65%, Missing); urinary bladder: 64.6983% (minimum 65%, Approved)",-0.241407,-0.0918552,-0.350871,0,7,partial,303.5,131.6,291.8,"small intestine: 303.5 nTPM (vital, limit 1); skin: 291.8 nTPM (manageable, limit 5); adipose tissue: 256.4 nTPM (manageable, limit 5); heart muscle: 253.9 nTPM (vital, limit 2); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (manageable, limit 5); salivary gland: 131.6 nTPM (protected, limit 4); colon: 129.9 nTPM (protected, limit 2); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 4); urinary bladder: 110 nTPM (protected, limit 4); kidney: 106.5 nTPM (vital, limit 1); spleen: 92.2 nTPM (manageable, limit 5); stomach: 91.6 nTPM (protected, limit 2); lymph node: 81.8 nTPM (protected, limit 2); thymus: 77.5 nTPM (manageable, limit 5); rectum: 53.5 nTPM (protected, limit 2); tongue: 48.1 nTPM (protected, limit 2); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 2); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 2); hippocampal formation: 28 nTPM (vital, limit 1); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 2); parathyroid gland: 20.5 nTPM (protected, limit 4); pancreas: 17.7 nTPM (vital, limit 2); liver: 17.4 nTPM (vital, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213145,CRIP1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.0175% (minimum 65%, Missing); colon: 60.8145% (minimum 70%, Missing); duodenum: 63.0788% (minimum 75%, Missing); esophagus: 63.5962% (minimum 65%, Approved); heart muscle: 44.2591% (minimum 70%, Approved); kidney: 65.4333% (minimum 75%, Missing); lung: 44.9599% (minimum 75%, Missing); salivary gland: 60.5042% (minimum 65%, Approved); skin: 40.8593% (minimum 65%, Missing); small intestine: 39.9129% (minimum 75%, Missing); stomach: 68.7585% (minimum 70%, Missing); thyroid gland: 53.3051% (minimum 65%, Missing); urinary bladder: 64.6983% (minimum 65%, Approved)",-0.241407,-0.0918552,-0.350871,0,7,partial,303.5,131.6,291.8,"small intestine: 303.5 nTPM (vital, limit 1); skin: 291.8 nTPM (manageable, limit 5); adipose tissue: 256.4 nTPM (manageable, limit 5); heart muscle: 253.9 nTPM (vital, limit 2); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (manageable, limit 5); salivary gland: 131.6 nTPM (protected, limit 4); colon: 129.9 nTPM (protected, limit 3); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 4); urinary bladder: 110 nTPM (protected, limit 4); kidney: 106.5 nTPM (vital, limit 1); spleen: 92.2 nTPM (manageable, limit 5); stomach: 91.6 nTPM (protected, limit 3); lymph node: 81.8 nTPM (protected, limit 3); thymus: 77.5 nTPM (manageable, limit 5); rectum: 53.5 nTPM (protected, limit 3); tongue: 48.1 nTPM (protected, limit 3); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 2); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 2); hippocampal formation: 28 nTPM (vital, limit 1); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 2); parathyroid gland: 20.5 nTPM (protected, limit 4); pancreas: 17.7 nTPM (vital, limit 2); liver: 17.4 nTPM (vital, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213145,CRIP1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.0175% (minimum 65%, Missing); colon: 60.8145% (minimum 70%, Missing); duodenum: 63.0788% (minimum 75%, Missing); esophagus: 63.5962% (minimum 65%, Approved); heart muscle: 44.2591% (minimum 70%, Approved); kidney: 65.4333% (minimum 75%, Missing); lung: 44.9599% (minimum 75%, Missing); salivary gland: 60.5042% (minimum 65%, Approved); skin: 40.8593% (minimum 65%, Missing); small intestine: 39.9129% (minimum 75%, Missing); stomach: 68.7585% (minimum 70%, Missing); thyroid gland: 53.3051% (minimum 65%, Missing); urinary bladder: 64.6983% (minimum 65%, Approved)",-0.241407,-0.0918552,-0.350871,0,7,partial,303.5,131.6,291.8,"small intestine: 303.5 nTPM (vital, limit 1); skin: 291.8 nTPM (manageable, limit 5); adipose tissue: 256.4 nTPM (manageable, limit 5); heart muscle: 253.9 nTPM (vital, limit 2); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (manageable, limit 5); salivary gland: 131.6 nTPM (protected, limit 4); colon: 129.9 nTPM (protected, limit 3); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 4); urinary bladder: 110 nTPM (protected, limit 4); kidney: 106.5 nTPM (vital, limit 1); spleen: 92.2 nTPM (manageable, limit 5); stomach: 91.6 nTPM (protected, limit 3); lymph node: 81.8 nTPM (protected, limit 3); thymus: 77.5 nTPM (manageable, limit 5); rectum: 53.5 nTPM (protected, limit 3); tongue: 48.1 nTPM (protected, limit 3); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 2); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 2); hippocampal formation: 28 nTPM (vital, limit 1); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 2); parathyroid gland: 20.5 nTPM (protected, limit 4); pancreas: 17.7 nTPM (vital, limit 2); liver: 17.4 nTPM (vital, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213145,CRIP1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.0175% (minimum 65%, Baseline (adaptation disabled)); colon: 60.8145% (minimum 70%, Baseline (adaptation disabled)); duodenum: 63.0788% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.5962% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 44.2591% (minimum 75%, Baseline (adaptation disabled)); kidney: 65.4333% (minimum 75%, Baseline (adaptation disabled)); lung: 44.9599% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.5042% (minimum 70%, Baseline (adaptation disabled)); skin: 40.8593% (minimum 65%, Baseline (adaptation disabled)); small intestine: 39.9129% (minimum 75%, Baseline (adaptation disabled)); stomach: 68.7585% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.3051% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 64.6983% (minimum 70%, Baseline (adaptation disabled))",-0.241407,-0.094958,-0.350871,0,7,partial,303.5,131.6,291.8,"small intestine: 303.5 nTPM (vital, limit 1); skin: 291.8 nTPM (manageable, limit 5); adipose tissue: 256.4 nTPM (manageable, limit 5); heart muscle: 253.9 nTPM (vital, limit 1); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (manageable, limit 5); salivary gland: 131.6 nTPM (protected, limit 3); colon: 129.9 nTPM (protected, limit 3); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 3); urinary bladder: 110 nTPM (protected, limit 3); kidney: 106.5 nTPM (vital, limit 1); spleen: 92.2 nTPM (manageable, limit 5); stomach: 91.6 nTPM (protected, limit 3); lymph node: 81.8 nTPM (protected, limit 3); thymus: 77.5 nTPM (manageable, limit 5); rectum: 53.5 nTPM (protected, limit 3); tongue: 48.1 nTPM (protected, limit 3); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 1); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 1); hippocampal formation: 28 nTPM (vital, limit 1); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 3); pancreas: 17.7 nTPM (vital, limit 1); liver: 17.4 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213145,CRIP1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3077% (minimum 95%, Missing); adrenal gland: 92.3077% (minimum 99%, Missing); amygdala: 62.6866% (minimum 99%, Missing); basal ganglia: 56.7568% (minimum 99%, Missing); bone marrow: 33.0709% (minimum 99%, Missing); cerebellum: 87.5000% (minimum 99%, Missing); cerebral cortex: 44.6809% (minimum 99%, Missing); choroid plexus: 94.3820% (minimum 99%, Missing); colon: 76.3636% (minimum 97%, Missing); duodenum: 75.6757% (minimum 99%, Missing); esophagus: 64.1221% (minimum 97%, Missing); heart muscle: 92.3077% (minimum 99%, Missing); hippocampal formation: 48.8372% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 87.5000% (minimum 99%, Missing); liver: 89.3617% (minimum 99%, Missing); lung: 81.5534% (minimum 99%, Missing); lymph node: 41.5842% (minimum 97%, Missing); midbrain: 48.2759% (minimum 99%, Missing); pancreas: 84.8485% (minimum 99%, Missing); parathyroid gland: 83.1683% (minimum 97%, Missing); pituitary gland: 88.4211% (minimum 99%, Missing); rectum: 77.0642% (minimum 97%, Missing); retina: 85.7143% (minimum 99%, Missing); salivary gland: 84.0000% (minimum 97%, Missing); skeletal muscle: 87.5000% (minimum 99%, Missing); skin: 61.3139% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 75.6757% (minimum 99%, Missing); spinal cord: 45.6522% (minimum 99%, Missing); spleen: 62.6866% (minimum 95%, Missing); stomach: 77.0642% (minimum 97%, Missing); thymus: 38.7097% (minimum 95%, Missing); thyroid gland: 80.7692% (minimum 95%, Missing); urinary bladder: 73.6842% (minimum 97%, Missing)",-0.562903,-0.554158,-0.659291,0,80,unavailable,17,11.8,13.3,"bone marrow: 17 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); lymph node: 11.8 nTPM (protected, limit 2); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); amygdala: 5 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); hypothalamus: 4.2 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213186,TRIM59,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 62.6866% (minimum 75%, Missing); basal ganglia: 56.7568% (minimum 75%, Missing); bone marrow: 33.0709% (minimum 75%, Missing); cerebral cortex: 44.6809% (minimum 75%, Missing); esophagus: 64.1221% (minimum 70%, Missing); hippocampal formation: 48.8372% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); lymph node: 41.5842% (minimum 70%, Missing); midbrain: 48.2759% (minimum 75%, Missing); skin: 61.3139% (minimum 65%, Missing); spinal cord: 45.6522% (minimum 75%, Missing); spleen: 62.6866% (minimum 65%, Missing); thymus: 38.7097% (minimum 65%, Missing)",-0.262903,-0.284158,-0.419291,0,80,unavailable,17,11.8,13.3,"bone marrow: 17 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); lymph node: 11.8 nTPM (protected, limit 2); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); amygdala: 5 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); hypothalamus: 4.2 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213186,TRIM59,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 62.6866% (minimum 75%, Missing); basal ganglia: 56.7568% (minimum 75%, Missing); bone marrow: 33.0709% (minimum 75%, Missing); cerebral cortex: 44.6809% (minimum 75%, Missing); esophagus: 64.1221% (minimum 70%, Missing); hippocampal formation: 48.8372% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); lymph node: 41.5842% (minimum 70%, Missing); midbrain: 48.2759% (minimum 75%, Missing); skin: 61.3139% (minimum 65%, Missing); spinal cord: 45.6522% (minimum 75%, Missing); spleen: 62.6866% (minimum 65%, Missing); thymus: 38.7097% (minimum 65%, Missing)",-0.262903,-0.284158,-0.419291,0,80,unavailable,17,11.8,13.3,"bone marrow: 17 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); lymph node: 11.8 nTPM (protected, limit 3); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); amygdala: 5 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); hypothalamus: 4.2 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213186,TRIM59,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 62.6866% (minimum 75%, Missing); basal ganglia: 56.7568% (minimum 75%, Missing); bone marrow: 33.0709% (minimum 75%, Missing); cerebral cortex: 44.6809% (minimum 75%, Missing); esophagus: 64.1221% (minimum 70%, Missing); hippocampal formation: 48.8372% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); lymph node: 41.5842% (minimum 70%, Missing); midbrain: 48.2759% (minimum 75%, Missing); skin: 61.3139% (minimum 65%, Missing); spinal cord: 45.6522% (minimum 75%, Missing); spleen: 62.6866% (minimum 65%, Missing); thymus: 38.7097% (minimum 65%, Missing)",-0.262903,-0.284158,-0.419291,0,80,unavailable,17,11.8,13.3,"bone marrow: 17 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); lymph node: 11.8 nTPM (protected, limit 3); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); amygdala: 5 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); hypothalamus: 4.2 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213186,TRIM59,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 62.6866% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.7568% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 33.0709% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 44.6809% (minimum 75%, Baseline (adaptation disabled)); esophagus: 64.1221% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 48.8372% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lymph node: 41.5842% (minimum 70%, Baseline (adaptation disabled)); midbrain: 48.2759% (minimum 75%, Baseline (adaptation disabled)); skin: 61.3139% (minimum 65%, Baseline (adaptation disabled)); spinal cord: 45.6522% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.6866% (minimum 65%, Baseline (adaptation disabled)); thymus: 38.7097% (minimum 65%, Baseline (adaptation disabled))",-0.262903,-0.284158,-0.419291,0,80,unavailable,17,11.8,13.3,"bone marrow: 17 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); lymph node: 11.8 nTPM (protected, limit 3); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); amygdala: 5 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); hypothalamus: 4.2 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213186,TRIM59,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7169% (minimum 99%, Missing); bone marrow: 98.6175% (minimum 99%, Missing); cerebral cortex: 96.3964% (minimum 99%, Missing); choroid plexus: 96.8326% (minimum 99%, Missing); colon: 95.9641% (minimum 97%, Missing); duodenum: 98.6175% (minimum 99%, Missing); heart muscle: 96.8326% (minimum 99%, Missing); kidney: 98.6175% (minimum 99%, Missing); lung: 98.1651% (minimum 99%, Missing); pancreas: 95.5357% (minimum 99%, Missing); parathyroid gland: 95.1111% (minimum 97%, Missing); pituitary gland: 96.8326% (minimum 99%, Missing); rectum: 95.1111% (minimum 97%, Missing); retina: 93.0435% (minimum 99%, Missing); skeletal muscle: 98.6175% (minimum 99%, Missing); small intestine: 98.6175% (minimum 99%, Missing); smooth muscle: 98.6175% (minimum 99%, Missing); stomach: 96.8326% (minimum 97%, Missing); thymus: 93.8596% (minimum 95%, Missing)",-0.0114035,-0.0188889,-0.0595652,0,80,unavailable,1.6,1.1,1.4,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213213,CCDC183,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288596,0.251111,0.180435,0,80,unavailable,1.6,1.1,1.4,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213213,CCDC183,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288596,0.251111,0.180435,0,80,unavailable,1.6,1.1,1.4,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213213,CCDC183,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288596,0.251111,0.180435,0,80,unavailable,1.6,1.1,1.4,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213213,CCDC183,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288596,0.251111,0.180435,0,80,unavailable,1.6,1.1,1.4,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213213,CCDC183,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000213215,OR2F1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000213215,OR2F1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000213215,OR2F1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000213215,OR2F1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000213215,OR2F1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0496874,0.03,0.00940625,0,1,partial,14.6,5,8.4,"smooth muscle: 14.6 nTPM (vital, limit 3); lung: 3.4 nTPM (vital, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213218,CSH2,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349687,0.3,0.249406,0,1,partial,14.6,5,8.4,"smooth muscle: 14.6 nTPM (vital, limit 3); lung: 3.4 nTPM (vital, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213218,CSH2,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349687,0.3,0.249406,0,1,partial,14.6,5,8.4,"smooth muscle: 14.6 nTPM (vital, limit 3); lung: 3.4 nTPM (vital, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213218,CSH2,grid_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349687,0.3,0.249406,0,1,partial,14.6,5,8.4,"smooth muscle: 14.6 nTPM (vital, limit 3); lung: 3.4 nTPM (vital, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213218,CSH2,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34738,0.298439,0.245456,0,1,partial,14.6,5,8.4,"smooth muscle: 14.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 3); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213218,CSH2,current_fixed,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 69.4444% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); lymph node: 54.3478% (minimum 97%, Missing); small intestine: 96.1538% (minimum 99%, Missing); spleen: 78.1250% (minimum 95%, Missing)",-0.16875,-0.426522,-0.295556,0,80,unavailable,1.1,2.1,0.7,"lymph node: 2.1 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213231,TCL1B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 69.4444% (minimum 75%, Missing); lymph node: 54.3478% (minimum 70%, Missing)",0.13125,-0.156522,-0.0555556,0,80,unavailable,1.1,2.1,0.7,"lymph node: 2.1 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213231,TCL1B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 69.4444% (minimum 75%, Missing); lymph node: 54.3478% (minimum 70%, Missing)",0.13125,-0.156522,-0.0555556,0,80,unavailable,1.1,2.1,0.7,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213231,TCL1B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 69.4444% (minimum 75%, Missing); lymph node: 54.3478% (minimum 70%, Missing)",0.13125,-0.156522,-0.0555556,0,80,unavailable,1.1,2.1,0.7,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213231,TCL1B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 69.4444% (minimum 75%, Baseline (adaptation disabled)); lymph node: 54.3478% (minimum 70%, Baseline (adaptation disabled))",0.13125,-0.156522,-0.0555556,0,80,unavailable,1.1,2.1,0.7,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213231,TCL1B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213265,TSGA13,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213265,TSGA13,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213265,TSGA13,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213265,TSGA13,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213265,TSGA13,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 90.0000% (minimum 99%, Missing); basal ganglia: 84.3750% (minimum 99%, Missing); cerebellum: 96.4286% (minimum 99%, Missing); cerebral cortex: 90.0000% (minimum 99%, Missing); hippocampal formation: 90.0000% (minimum 99%, Missing); hypothalamus: 93.1034% (minimum 99%, Missing); midbrain: 90.0000% (minimum 99%, Missing); spinal cord: 96.4286% (minimum 99%, Missing)",0.05,0.03,-0.14625,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213401,MAGEA12,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.09375,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213401,MAGEA12,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.09375,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213401,MAGEA12,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.09375,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213401,MAGEA12,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.09375,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213401,MAGEA12,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.7500% (minimum 99%, Missing)",0.05,0.03,-0.0025,0,4,partial,0.1,0.1,0,,,49,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213471,TTLL13,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.2375,0,4,partial,0.1,0.1,0,,,49,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213471,TTLL13,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.2375,0,4,partial,0.1,0.1,0,,,49,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213471,TTLL13,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.2375,0,4,partial,0.1,0.1,0,,,49,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213471,TTLL13,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.35,0.2875,0.2375,0,4,partial,0.1,0.1,0,,,49,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213471,TTLL13,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.7273% (minimum 95%, Missing); adrenal gland: 65.4545% (minimum 99%, Missing); amygdala: 81.8182% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 80.8989% (minimum 99%, Missing); cerebellum: 72.7273% (minimum 99%, Missing); cerebral cortex: 72.7273% (minimum 99%, Missing); choroid plexus: 73.4694% (minimum 99%, Missing); colon: 75.7895% (minimum 97%, Missing); duodenum: 75.7895% (minimum 99%, Missing); esophagus: 66.0550% (minimum 97%, Missing); heart muscle: 71.2871% (minimum 99%, Missing); hippocampal formation: 78.2609% (minimum 99%, Missing); hypothalamus: 73.4694% (minimum 99%, Missing); kidney: 62.6087% (minimum 99%, Missing); liver: 69.9029% (minimum 99%, Missing); lung: 75.7895% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 76.5957% (minimum 99%, Missing); pancreas: 71.2871% (minimum 99%, Missing); parathyroid gland: 92.3077% (minimum 97%, Missing); pituitary gland: 42.6036% (minimum 99%, Missing); rectum: 83.7209% (minimum 97%, Missing); retina: 80.0000% (minimum 99%, Missing); salivary gland: 72.0000% (minimum 97%, Missing); skeletal muscle: 80.8989% (minimum 99%, Missing); skin: 66.0550% (minimum 95%, Missing); small intestine: 72.7273% (minimum 99%, Missing); smooth muscle: 91.1392% (minimum 99%, Missing); spinal cord: 77.4194% (minimum 99%, Missing); spleen: 67.9245% (minimum 95%, Missing); stomach: 73.4694% (minimum 97%, Missing); thyroid gland: 77.4194% (minimum 95%, Missing); tongue: 87.8049% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.28945,-0.30945,-0.563964,0,80,unavailable,9.7,3.7,3.7,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213588,ZBTB9,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.4545% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 72.7273% (minimum 75%, Missing); choroid plexus: 73.4694% (minimum 75%, Missing); esophagus: 66.0550% (minimum 70%, Missing); heart muscle: 71.2871% (minimum 75%, Missing); hypothalamus: 73.4694% (minimum 75%, Missing); kidney: 62.6087% (minimum 75%, Missing); liver: 69.9029% (minimum 75%, Missing); pancreas: 71.2871% (minimum 75%, Missing); pituitary gland: 42.6036% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing)",0.0105505,-0.0394495,-0.323964,0,80,unavailable,9.7,3.7,3.7,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213588,ZBTB9,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.4545% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 72.7273% (minimum 75%, Missing); choroid plexus: 73.4694% (minimum 75%, Missing); esophagus: 66.0550% (minimum 70%, Missing); heart muscle: 71.2871% (minimum 75%, Missing); hypothalamus: 73.4694% (minimum 75%, Missing); kidney: 62.6087% (minimum 75%, Missing); liver: 69.9029% (minimum 75%, Missing); pancreas: 71.2871% (minimum 75%, Missing); pituitary gland: 42.6036% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing)",0.0105505,-0.0394495,-0.323964,0,80,unavailable,9.7,3.7,3.7,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213588,ZBTB9,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.4545% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 72.7273% (minimum 75%, Missing); choroid plexus: 73.4694% (minimum 75%, Missing); esophagus: 66.0550% (minimum 70%, Missing); heart muscle: 71.2871% (minimum 75%, Missing); hypothalamus: 73.4694% (minimum 75%, Missing); kidney: 62.6087% (minimum 75%, Missing); liver: 69.9029% (minimum 75%, Missing); pancreas: 71.2871% (minimum 75%, Missing); pituitary gland: 42.6036% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing)",0.0105505,-0.0394495,-0.323964,0,80,unavailable,9.7,3.7,3.7,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213588,ZBTB9,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.4545% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 72.7273% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.7273% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.4694% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.0550% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 71.2871% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 73.4694% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.6087% (minimum 75%, Baseline (adaptation disabled)); liver: 69.9029% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.2871% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 42.6036% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.7273% (minimum 75%, Baseline (adaptation disabled))",0.0105505,-0.0394495,-0.323964,0,80,unavailable,9.7,3.7,3.7,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213588,ZBTB9,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.5537% (minimum 95%, Enhanced)",0.0446333,0.0273094,-0.0444625,0,3,partial,11.6,1.3,2.5,"bone marrow: 11.6 nTPM (vital, limit 6)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213714,FAM209B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344633,0.297309,0.241971,0,3,partial,11.6,1.3,2.5,"bone marrow: 11.6 nTPM (vital, limit 6)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213714,FAM209B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344633,0.297309,0.241971,0,3,partial,11.6,1.3,2.5,"bone marrow: 11.6 nTPM (vital, limit 6)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213714,FAM209B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344633,0.297309,0.241971,0,3,partial,11.6,1.3,2.5,"bone marrow: 11.6 nTPM (vital, limit 6)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213714,FAM209B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328012,0.288444,0.155537,0,3,partial,11.6,1.3,2.5,"bone marrow: 11.6 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213714,FAM209B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9937% (minimum 90%, Approved); adrenal gland: 60.2716% (minimum 99%, Missing); amygdala: 65.7407% (minimum 99%, Missing); basal ganglia: 65.0183% (minimum 99%, Missing); bone marrow: 46.6491% (minimum 99%, Missing); cerebellum: 62.6102% (minimum 99%, Missing); cerebral cortex: 64.6630% (minimum 99%, Missing); choroid plexus: 50.2833% (minimum 99%, Missing); colon: 55.5556% (minimum 97%, Missing); duodenum: 66.7293% (minimum 99%, Missing); esophagus: 55.6426% (minimum 97%, Missing); heart muscle: 61.4187% (minimum 99%, Missing); hippocampal formation: 65.4982% (minimum 99%, Missing); hypothalamus: 65.7407% (minimum 99%, Missing); kidney: 53.4639% (minimum 99%, Missing); liver: 49.1690% (minimum 99%, Missing); lung: 59.5638% (minimum 99%, Missing); lymph node: 52.6706% (minimum 97%, Missing); midbrain: 64.6630% (minimum 99%, Missing); pancreas: 54.2813% (minimum 99%, Missing); parathyroid gland: 50.1412% (minimum 97%, Missing); pituitary gland: 67.4905% (minimum 99%, Missing); rectum: 58.1967% (minimum 97%, Missing); retina: 68.4008% (minimum 99%, Missing); salivary gland: 59.9662% (minimum 97%, Missing); skeletal muscle: 45.2229% (minimum 99%, Missing); skin: 54.5315% (minimum 95%, Missing); small intestine: 62.7208% (minimum 99%, Missing); smooth muscle: 52.4372% (minimum 99%, Missing); spinal cord: 63.8489% (minimum 99%, Missing); spleen: 60.8919% (minimum 90%, Approved); stomach: 55.4688% (minimum 97%, Missing); thymus: 50.6419% (minimum 95%, Missing); thyroid gland: 52.3599% (minimum 95%, Missing); tongue: 47.0199% (minimum 97%, Missing); urinary bladder: 43.6118% (minimum 97%, Missing)",-0.443581,-0.533882,-0.537771,0,1,partial,43,45.9,34.6,"urinary bladder: 45.9 nTPM (protected, limit 2); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 2); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 2); choroid plexus: 35.1 nTPM (vital, limit 1); thymus: 34.6 nTPM (manageable, limit 5); thyroid gland: 32.3 nTPM (manageable, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 2); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); skin: 29.6 nTPM (manageable, limit 5); stomach: 28.5 nTPM (protected, limit 2); colon: 28.4 nTPM (protected, limit 2); esophagus: 28.3 nTPM (protected, limit 2); adipose tissue: 27.9 nTPM (manageable, limit 10); rectum: 25.5 nTPM (protected, limit 2); lung: 24.1 nTPM (vital, limit 1); salivary gland: 23.7 nTPM (protected, limit 2); adrenal gland: 23.4 nTPM (vital, limit 1); spleen: 22.8 nTPM (manageable, limit 10); heart muscle: 22.3 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213782,DDX47,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9937% (minimum 60%, Approved); adrenal gland: 60.2716% (minimum 75%, Missing); amygdala: 65.7407% (minimum 75%, Missing); basal ganglia: 65.0183% (minimum 75%, Missing); bone marrow: 46.6491% (minimum 75%, Missing); cerebellum: 62.6102% (minimum 75%, Missing); cerebral cortex: 64.6630% (minimum 75%, Missing); choroid plexus: 50.2833% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 66.7293% (minimum 75%, Missing); esophagus: 55.6426% (minimum 70%, Missing); heart muscle: 61.4187% (minimum 75%, Missing); hippocampal formation: 65.4982% (minimum 75%, Missing); hypothalamus: 65.7407% (minimum 75%, Missing); kidney: 53.4639% (minimum 75%, Missing); liver: 49.1690% (minimum 75%, Missing); lung: 59.5638% (minimum 75%, Missing); lymph node: 52.6706% (minimum 70%, Missing); midbrain: 64.6630% (minimum 75%, Missing); pancreas: 54.2813% (minimum 75%, Missing); parathyroid gland: 50.1412% (minimum 70%, Missing); pituitary gland: 67.4905% (minimum 75%, Missing); rectum: 58.1967% (minimum 70%, Missing); retina: 68.4008% (minimum 75%, Missing); salivary gland: 59.9662% (minimum 70%, Missing); skeletal muscle: 45.2229% (minimum 75%, Missing); skin: 54.5315% (minimum 65%, Missing); small intestine: 62.7208% (minimum 75%, Missing); smooth muscle: 52.4372% (minimum 75%, Missing); spinal cord: 63.8489% (minimum 75%, Missing); stomach: 55.4688% (minimum 70%, Missing); thymus: 50.6419% (minimum 65%, Missing); thyroid gland: 52.3599% (minimum 65%, Missing); tongue: 47.0199% (minimum 70%, Missing); urinary bladder: 43.6118% (minimum 70%, Missing)",-0.143581,-0.263882,-0.297771,0,1,partial,43,45.9,34.6,"urinary bladder: 45.9 nTPM (protected, limit 2); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 2); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 2); choroid plexus: 35.1 nTPM (vital, limit 1); thymus: 34.6 nTPM (manageable, limit 5); thyroid gland: 32.3 nTPM (manageable, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 2); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); skin: 29.6 nTPM (manageable, limit 5); stomach: 28.5 nTPM (protected, limit 2); colon: 28.4 nTPM (protected, limit 2); esophagus: 28.3 nTPM (protected, limit 2); adipose tissue: 27.9 nTPM (manageable, limit 10); rectum: 25.5 nTPM (protected, limit 2); lung: 24.1 nTPM (vital, limit 1); salivary gland: 23.7 nTPM (protected, limit 2); adrenal gland: 23.4 nTPM (vital, limit 1); spleen: 22.8 nTPM (manageable, limit 10); heart muscle: 22.3 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213782,DDX47,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9937% (minimum 60%, Approved); adrenal gland: 60.2716% (minimum 75%, Missing); amygdala: 65.7407% (minimum 75%, Missing); basal ganglia: 65.0183% (minimum 75%, Missing); bone marrow: 46.6491% (minimum 75%, Missing); cerebellum: 62.6102% (minimum 75%, Missing); cerebral cortex: 64.6630% (minimum 75%, Missing); choroid plexus: 50.2833% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 66.7293% (minimum 75%, Missing); esophagus: 55.6426% (minimum 70%, Missing); heart muscle: 61.4187% (minimum 75%, Missing); hippocampal formation: 65.4982% (minimum 75%, Missing); hypothalamus: 65.7407% (minimum 75%, Missing); kidney: 53.4639% (minimum 75%, Missing); liver: 49.1690% (minimum 75%, Missing); lung: 59.5638% (minimum 75%, Missing); lymph node: 52.6706% (minimum 70%, Missing); midbrain: 64.6630% (minimum 75%, Missing); pancreas: 54.2813% (minimum 75%, Missing); parathyroid gland: 50.1412% (minimum 70%, Missing); pituitary gland: 67.4905% (minimum 75%, Missing); rectum: 58.1967% (minimum 70%, Missing); retina: 68.4008% (minimum 75%, Missing); salivary gland: 59.9662% (minimum 70%, Missing); skeletal muscle: 45.2229% (minimum 75%, Missing); skin: 54.5315% (minimum 65%, Missing); small intestine: 62.7208% (minimum 75%, Missing); smooth muscle: 52.4372% (minimum 75%, Missing); spinal cord: 63.8489% (minimum 75%, Missing); stomach: 55.4688% (minimum 70%, Missing); thymus: 50.6419% (minimum 65%, Missing); thyroid gland: 52.3599% (minimum 65%, Missing); tongue: 47.0199% (minimum 70%, Missing); urinary bladder: 43.6118% (minimum 70%, Missing)",-0.143581,-0.263882,-0.297771,0,1,partial,43,45.9,34.6,"urinary bladder: 45.9 nTPM (protected, limit 3); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 3); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 3); choroid plexus: 35.1 nTPM (vital, limit 1); thymus: 34.6 nTPM (manageable, limit 5); thyroid gland: 32.3 nTPM (manageable, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 3); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); skin: 29.6 nTPM (manageable, limit 5); stomach: 28.5 nTPM (protected, limit 3); colon: 28.4 nTPM (protected, limit 3); esophagus: 28.3 nTPM (protected, limit 3); adipose tissue: 27.9 nTPM (manageable, limit 10); rectum: 25.5 nTPM (protected, limit 3); lung: 24.1 nTPM (vital, limit 1); salivary gland: 23.7 nTPM (protected, limit 3); adrenal gland: 23.4 nTPM (vital, limit 1); spleen: 22.8 nTPM (manageable, limit 10); heart muscle: 22.3 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213782,DDX47,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9937% (minimum 60%, Approved); adrenal gland: 60.2716% (minimum 75%, Missing); amygdala: 65.7407% (minimum 75%, Missing); basal ganglia: 65.0183% (minimum 75%, Missing); bone marrow: 46.6491% (minimum 75%, Missing); cerebellum: 62.6102% (minimum 75%, Missing); cerebral cortex: 64.6630% (minimum 75%, Missing); choroid plexus: 50.2833% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 66.7293% (minimum 75%, Missing); esophagus: 55.6426% (minimum 70%, Missing); heart muscle: 61.4187% (minimum 75%, Missing); hippocampal formation: 65.4982% (minimum 75%, Missing); hypothalamus: 65.7407% (minimum 75%, Missing); kidney: 53.4639% (minimum 75%, Missing); liver: 49.1690% (minimum 75%, Missing); lung: 59.5638% (minimum 75%, Missing); lymph node: 52.6706% (minimum 70%, Missing); midbrain: 64.6630% (minimum 75%, Missing); pancreas: 54.2813% (minimum 75%, Missing); parathyroid gland: 50.1412% (minimum 70%, Missing); pituitary gland: 67.4905% (minimum 75%, Missing); rectum: 58.1967% (minimum 70%, Missing); retina: 68.4008% (minimum 75%, Missing); salivary gland: 59.9662% (minimum 70%, Missing); skeletal muscle: 45.2229% (minimum 75%, Missing); skin: 54.5315% (minimum 65%, Missing); small intestine: 62.7208% (minimum 75%, Missing); smooth muscle: 52.4372% (minimum 75%, Missing); spinal cord: 63.8489% (minimum 75%, Missing); stomach: 55.4688% (minimum 70%, Missing); thymus: 50.6419% (minimum 65%, Missing); thyroid gland: 52.3599% (minimum 65%, Missing); tongue: 47.0199% (minimum 70%, Missing); urinary bladder: 43.6118% (minimum 70%, Missing)",-0.143581,-0.263882,-0.297771,0,1,partial,43,45.9,34.6,"urinary bladder: 45.9 nTPM (protected, limit 3); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 3); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 3); choroid plexus: 35.1 nTPM (vital, limit 1); thymus: 34.6 nTPM (manageable, limit 5); thyroid gland: 32.3 nTPM (manageable, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 3); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); skin: 29.6 nTPM (manageable, limit 5); stomach: 28.5 nTPM (protected, limit 3); colon: 28.4 nTPM (protected, limit 3); esophagus: 28.3 nTPM (protected, limit 3); adipose tissue: 27.9 nTPM (manageable, limit 10); rectum: 25.5 nTPM (protected, limit 3); lung: 24.1 nTPM (vital, limit 1); salivary gland: 23.7 nTPM (protected, limit 3); adrenal gland: 23.4 nTPM (vital, limit 1); spleen: 22.8 nTPM (manageable, limit 10); heart muscle: 22.3 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213782,DDX47,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9937% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 60.2716% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.7407% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.0183% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 46.6491% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 62.6102% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.6630% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 50.2833% (minimum 75%, Baseline (adaptation disabled)); colon: 55.5556% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.7293% (minimum 75%, Baseline (adaptation disabled)); esophagus: 55.6426% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 61.4187% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 65.4982% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.7407% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.4639% (minimum 75%, Baseline (adaptation disabled)); liver: 49.1690% (minimum 75%, Baseline (adaptation disabled)); lung: 59.5638% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.6706% (minimum 70%, Baseline (adaptation disabled)); midbrain: 64.6630% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.2813% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.1412% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 67.4905% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.1967% (minimum 70%, Baseline (adaptation disabled)); retina: 68.4008% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.9662% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 45.2229% (minimum 75%, Baseline (adaptation disabled)); skin: 54.5315% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.7208% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 52.4372% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 63.8489% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.8919% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.4688% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.6419% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.3599% (minimum 65%, Baseline (adaptation disabled)); tongue: 47.0199% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 43.6118% (minimum 70%, Baseline (adaptation disabled))",-0.143581,-0.263882,-0.297771,0,1,partial,43,45.9,34.6,"urinary bladder: 45.9 nTPM (protected, limit 3); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 3); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 3); choroid plexus: 35.1 nTPM (vital, limit 1); thymus: 34.6 nTPM (manageable, limit 5); thyroid gland: 32.3 nTPM (manageable, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 3); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); skin: 29.6 nTPM (manageable, limit 5); stomach: 28.5 nTPM (protected, limit 3); colon: 28.4 nTPM (protected, limit 3); esophagus: 28.3 nTPM (protected, limit 3); adipose tissue: 27.9 nTPM (manageable, limit 5); rectum: 25.5 nTPM (protected, limit 3); lung: 24.1 nTPM (vital, limit 1); salivary gland: 23.7 nTPM (protected, limit 3); adrenal gland: 23.4 nTPM (vital, limit 1); spleen: 22.8 nTPM (manageable, limit 5); heart muscle: 22.3 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213782,DDX47,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9375% (minimum 95%, Missing); adrenal gland: 69.6429% (minimum 99%, Missing); amygdala: 81.2500% (minimum 99%, Missing); basal ganglia: 81.2500% (minimum 99%, Missing); bone marrow: 44.3182% (minimum 99%, Missing); cerebellum: 70.9091% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); choroid plexus: 76.4706% (minimum 99%, Missing); colon: 58.2090% (minimum 97%, Missing); duodenum: 61.9048% (minimum 99%, Missing); esophagus: 61.9048% (minimum 97%, Missing); heart muscle: 66.1017% (minimum 99%, Missing); hippocampal formation: 81.2500% (minimum 99%, Missing); hypothalamus: 81.2500% (minimum 99%, Missing); kidney: 61.9048% (minimum 99%, Missing); liver: 72.2222% (minimum 99%, Missing); lung: 58.2090% (minimum 99%, Missing); lymph node: 48.1481% (minimum 97%, Missing); midbrain: 81.2500% (minimum 99%, Missing); pancreas: 66.1017% (minimum 99%, Missing); parathyroid gland: 52.7027% (minimum 97%, Missing); pituitary gland: 81.2500% (minimum 99%, Missing); rectum: 56.5217% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); salivary gland: 66.1017% (minimum 97%, Missing); skeletal muscle: 86.6667% (minimum 99%, Missing); skin: 56.5217% (minimum 95%, Missing); small intestine: 60.9375% (minimum 99%, Missing); smooth muscle: 67.2414% (minimum 99%, Missing); spinal cord: 78.0000% (minimum 99%, Missing); spleen: 52.7027% (minimum 95%, Missing); stomach: 52.7027% (minimum 97%, Missing); thymus: 48.7500% (minimum 95%, Missing); thyroid gland: 52.0000% (minimum 95%, Missing); tongue: 67.2414% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",-0.4625,-0.488519,-0.546818,0,80,unavailable,4.9,4.2,4.1,"bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213799,ZNF845,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9375% (minimum 65%, Missing); adrenal gland: 69.6429% (minimum 75%, Missing); bone marrow: 44.3182% (minimum 75%, Missing); cerebellum: 70.9091% (minimum 75%, Missing); colon: 58.2090% (minimum 70%, Missing); duodenum: 61.9048% (minimum 75%, Missing); esophagus: 61.9048% (minimum 70%, Missing); heart muscle: 66.1017% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 72.2222% (minimum 75%, Missing); lung: 58.2090% (minimum 75%, Missing); lymph node: 48.1481% (minimum 70%, Missing); pancreas: 66.1017% (minimum 75%, Missing); parathyroid gland: 52.7027% (minimum 70%, Missing); rectum: 56.5217% (minimum 70%, Missing); salivary gland: 66.1017% (minimum 70%, Missing); skin: 56.5217% (minimum 65%, Missing); small intestine: 60.9375% (minimum 75%, Missing); smooth muscle: 67.2414% (minimum 75%, Missing); spleen: 52.7027% (minimum 65%, Missing); stomach: 52.7027% (minimum 70%, Missing); thymus: 48.7500% (minimum 65%, Missing); thyroid gland: 52.0000% (minimum 65%, Missing); tongue: 67.2414% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.1625,-0.218519,-0.306818,0,80,unavailable,4.9,4.2,4.1,"bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213799,ZNF845,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9375% (minimum 65%, Missing); adrenal gland: 69.6429% (minimum 75%, Missing); bone marrow: 44.3182% (minimum 75%, Missing); cerebellum: 70.9091% (minimum 75%, Missing); colon: 58.2090% (minimum 70%, Missing); duodenum: 61.9048% (minimum 75%, Missing); esophagus: 61.9048% (minimum 70%, Missing); heart muscle: 66.1017% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 72.2222% (minimum 75%, Missing); lung: 58.2090% (minimum 75%, Missing); lymph node: 48.1481% (minimum 70%, Missing); pancreas: 66.1017% (minimum 75%, Missing); parathyroid gland: 52.7027% (minimum 70%, Missing); rectum: 56.5217% (minimum 70%, Missing); salivary gland: 66.1017% (minimum 70%, Missing); skin: 56.5217% (minimum 65%, Missing); small intestine: 60.9375% (minimum 75%, Missing); smooth muscle: 67.2414% (minimum 75%, Missing); spleen: 52.7027% (minimum 65%, Missing); stomach: 52.7027% (minimum 70%, Missing); thymus: 48.7500% (minimum 65%, Missing); thyroid gland: 52.0000% (minimum 65%, Missing); tongue: 67.2414% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.1625,-0.218519,-0.306818,0,80,unavailable,4.9,4.2,4.1,"bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213799,ZNF845,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9375% (minimum 65%, Missing); adrenal gland: 69.6429% (minimum 75%, Missing); bone marrow: 44.3182% (minimum 75%, Missing); cerebellum: 70.9091% (minimum 75%, Missing); colon: 58.2090% (minimum 70%, Missing); duodenum: 61.9048% (minimum 75%, Missing); esophagus: 61.9048% (minimum 70%, Missing); heart muscle: 66.1017% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 72.2222% (minimum 75%, Missing); lung: 58.2090% (minimum 75%, Missing); lymph node: 48.1481% (minimum 70%, Missing); pancreas: 66.1017% (minimum 75%, Missing); parathyroid gland: 52.7027% (minimum 70%, Missing); rectum: 56.5217% (minimum 70%, Missing); salivary gland: 66.1017% (minimum 70%, Missing); skin: 56.5217% (minimum 65%, Missing); small intestine: 60.9375% (minimum 75%, Missing); smooth muscle: 67.2414% (minimum 75%, Missing); spleen: 52.7027% (minimum 65%, Missing); stomach: 52.7027% (minimum 70%, Missing); thymus: 48.7500% (minimum 65%, Missing); thyroid gland: 52.0000% (minimum 65%, Missing); tongue: 67.2414% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.1625,-0.218519,-0.306818,0,80,unavailable,4.9,4.2,4.1,"bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213799,ZNF845,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9375% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 69.6429% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 44.3182% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.9091% (minimum 75%, Baseline (adaptation disabled)); colon: 58.2090% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.9048% (minimum 75%, Baseline (adaptation disabled)); esophagus: 61.9048% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.1017% (minimum 75%, Baseline (adaptation disabled)); kidney: 61.9048% (minimum 75%, Baseline (adaptation disabled)); liver: 72.2222% (minimum 75%, Baseline (adaptation disabled)); lung: 58.2090% (minimum 75%, Baseline (adaptation disabled)); lymph node: 48.1481% (minimum 70%, Baseline (adaptation disabled)); pancreas: 66.1017% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.7027% (minimum 70%, Baseline (adaptation disabled)); rectum: 56.5217% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 66.1017% (minimum 70%, Baseline (adaptation disabled)); skin: 56.5217% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.9375% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 67.2414% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.7027% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.7027% (minimum 70%, Baseline (adaptation disabled)); thymus: 48.7500% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.2414% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 70%, Baseline (adaptation disabled))",-0.1625,-0.218519,-0.306818,0,80,unavailable,4.9,4.2,4.1,"bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213799,ZNF845,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 94.3262% (minimum 99%, Missing); choroid plexus: 97.0803% (minimum 99%, Missing); retina: 97.0803% (minimum 99%, Missing); skin: 5.3510% (minimum 95%, Missing); thymus: 85.8065% (minimum 95%, Missing)",-0.89649,0.0188476,-0.0467376,0,6,partial,1.6,0.7,470.5,"skin: 470.5 nTPM (manageable, limit 5); bone marrow: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); spleen / cells in red pulp: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in spinous layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213927,CCL27,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 5.3510% (minimum 65%, Missing)",-0.59649,0.288848,0.193262,0,6,partial,1.6,0.7,470.5,"skin: 470.5 nTPM (manageable, limit 5); bone marrow: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); spleen / cells in red pulp: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in spinous layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213927,CCL27,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 5.3510% (minimum 65%, Missing)",-0.59649,0.288848,0.193262,0,6,partial,1.6,0.7,470.5,"skin: 470.5 nTPM (manageable, limit 5); bone marrow: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); spleen / cells in red pulp: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in spinous layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213927,CCL27,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 5.3510% (minimum 65%, Missing)",-0.59649,0.288848,0.193262,0,6,partial,1.6,0.7,470.5,"skin: 470.5 nTPM (manageable, limit 5); bone marrow: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); spleen / cells in red pulp: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in spinous layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213927,CCL27,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 5.3510% (minimum 65%, Baseline (adaptation disabled))",-0.59649,0.274359,0.193262,0,6,partial,1.6,0.7,470.5,"skin: 470.5 nTPM (manageable, limit 5); bone marrow: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); spleen / cells in red pulp: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in spinous layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000213927,CCL27,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214107,MAGEB1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214107,MAGEB1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214107,MAGEB1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214107,MAGEB1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214107,MAGEB1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 88.8889% (minimum 99%, Missing); cerebral cortex: 88.8889% (minimum 99%, Missing); heart muscle: 88.8889% (minimum 99%, Missing); hippocampal formation: 88.8889% (minimum 99%, Missing); pituitary gland: 61.5385% (minimum 99%, Missing)",0.05,0.03,-0.374615,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214216,IQCJ,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 61.5385% (minimum 75%, Missing)",0.35,0.3,-0.134615,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214216,IQCJ,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 61.5385% (minimum 75%, Missing)",0.35,0.3,-0.134615,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214216,IQCJ,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 61.5385% (minimum 75%, Missing)",0.35,0.3,-0.134615,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214216,IQCJ,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 61.5385% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.134615,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214216,IQCJ,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3750% (minimum 90%, Approved); adrenal gland: 82.6087% (minimum 98%, Approved); amygdala: 65.5172% (minimum 99%, Missing); basal ganglia: 70.3704% (minimum 99%, Missing); bone marrow: 79.1667% (minimum 98%, Approved); cerebellum: 67.8571% (minimum 98%, Approved); cerebral cortex: 67.8571% (minimum 99%, Missing); choroid plexus: 73.0769% (minimum 99%, Missing); colon: 59.3750% (minimum 97%, Missing); duodenum: 73.0769% (minimum 99%, Missing); esophagus: 70.3704% (minimum 97%, Missing); heart muscle: 67.8571% (minimum 98%, Approved); hippocampal formation: 63.3333% (minimum 99%, Missing); hypothalamus: 57.5758% (minimum 99%, Missing); kidney: 70.3704% (minimum 98%, Approved); liver: 46.3415% (minimum 98%, Approved); lung: 55.8824% (minimum 98%, Approved); lymph node: 55.8824% (minimum 95%, Approved); midbrain: 65.5172% (minimum 99%, Missing); pancreas: 54.2857% (minimum 98%, Approved); parathyroid gland: 79.1667% (minimum 95%, Approved); pituitary gland: 59.3750% (minimum 99%, Missing); rectum: 79.1667% (minimum 97%, Missing); retina: 70.3704% (minimum 99%, Missing); salivary gland: 67.8571% (minimum 95%, Approved); skeletal muscle: 76.0000% (minimum 98%, Approved); skin: 79.1667% (minimum 90%, Approved); small intestine: 54.2857% (minimum 99%, Missing); smooth muscle: 63.3333% (minimum 98%, Approved); spinal cord: 57.5758% (minimum 99%, Missing); spleen: 42.2222% (minimum 90%, Approved); stomach: 67.8571% (minimum 97%, Missing); thymus: 26.3889% (minimum 95%, Missing); thyroid gland: 59.3750% (minimum 90%, Approved); tongue: 70.3704% (minimum 97%, Missing); urinary bladder: 57.5758% (minimum 95%, Approved)",-0.686111,-0.391176,-0.516585,0,1,partial,2.2,1.5,5.3,"thymus: 5.3 nTPM (manageable, limit 5); liver: 2.2 nTPM (vital, limit 2); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214226,C17orf67,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3750% (minimum 60%, Approved); amygdala: 65.5172% (minimum 75%, Missing); basal ganglia: 70.3704% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 70%, Approved); cerebral cortex: 67.8571% (minimum 75%, Missing); choroid plexus: 73.0769% (minimum 75%, Missing); colon: 59.3750% (minimum 70%, Missing); duodenum: 73.0769% (minimum 75%, Missing); heart muscle: 67.8571% (minimum 70%, Approved); hippocampal formation: 63.3333% (minimum 75%, Missing); hypothalamus: 57.5758% (minimum 75%, Missing); liver: 46.3415% (minimum 70%, Approved); lung: 55.8824% (minimum 70%, Approved); lymph node: 55.8824% (minimum 65%, Approved); midbrain: 65.5172% (minimum 75%, Missing); pancreas: 54.2857% (minimum 70%, Approved); pituitary gland: 59.3750% (minimum 75%, Missing); retina: 70.3704% (minimum 75%, Missing); small intestine: 54.2857% (minimum 75%, Missing); smooth muscle: 63.3333% (minimum 70%, Approved); spinal cord: 57.5758% (minimum 75%, Missing); spleen: 42.2222% (minimum 60%, Approved); stomach: 67.8571% (minimum 70%, Missing); thymus: 26.3889% (minimum 65%, Missing); thyroid gland: 59.3750% (minimum 60%, Approved); urinary bladder: 57.5758% (minimum 65%, Approved)",-0.386111,-0.10625,-0.236585,0,1,partial,2.2,1.5,5.3,"thymus: 5.3 nTPM (manageable, limit 5); liver: 2.2 nTPM (vital, limit 2); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214226,C17orf67,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3750% (minimum 60%, Approved); amygdala: 65.5172% (minimum 75%, Missing); basal ganglia: 70.3704% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 70%, Approved); cerebral cortex: 67.8571% (minimum 75%, Missing); choroid plexus: 73.0769% (minimum 75%, Missing); colon: 59.3750% (minimum 70%, Missing); duodenum: 73.0769% (minimum 75%, Missing); heart muscle: 67.8571% (minimum 70%, Approved); hippocampal formation: 63.3333% (minimum 75%, Missing); hypothalamus: 57.5758% (minimum 75%, Missing); liver: 46.3415% (minimum 70%, Approved); lung: 55.8824% (minimum 70%, Approved); lymph node: 55.8824% (minimum 65%, Approved); midbrain: 65.5172% (minimum 75%, Missing); pancreas: 54.2857% (minimum 70%, Approved); pituitary gland: 59.3750% (minimum 75%, Missing); retina: 70.3704% (minimum 75%, Missing); small intestine: 54.2857% (minimum 75%, Missing); smooth muscle: 63.3333% (minimum 70%, Approved); spinal cord: 57.5758% (minimum 75%, Missing); spleen: 42.2222% (minimum 60%, Approved); stomach: 67.8571% (minimum 70%, Missing); thymus: 26.3889% (minimum 65%, Missing); thyroid gland: 59.3750% (minimum 60%, Approved); urinary bladder: 57.5758% (minimum 65%, Approved)",-0.386111,-0.10625,-0.236585,0,1,partial,2.2,1.5,5.3,"thymus: 5.3 nTPM (manageable, limit 5); liver: 2.2 nTPM (vital, limit 2); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214226,C17orf67,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3750% (minimum 60%, Approved); amygdala: 65.5172% (minimum 75%, Missing); basal ganglia: 70.3704% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 70%, Approved); cerebral cortex: 67.8571% (minimum 75%, Missing); choroid plexus: 73.0769% (minimum 75%, Missing); colon: 59.3750% (minimum 70%, Missing); duodenum: 73.0769% (minimum 75%, Missing); heart muscle: 67.8571% (minimum 70%, Approved); hippocampal formation: 63.3333% (minimum 75%, Missing); hypothalamus: 57.5758% (minimum 75%, Missing); liver: 46.3415% (minimum 70%, Approved); lung: 55.8824% (minimum 70%, Approved); lymph node: 55.8824% (minimum 65%, Approved); midbrain: 65.5172% (minimum 75%, Missing); pancreas: 54.2857% (minimum 70%, Approved); pituitary gland: 59.3750% (minimum 75%, Missing); retina: 70.3704% (minimum 75%, Missing); small intestine: 54.2857% (minimum 75%, Missing); smooth muscle: 63.3333% (minimum 70%, Approved); spinal cord: 57.5758% (minimum 75%, Missing); spleen: 42.2222% (minimum 60%, Approved); stomach: 67.8571% (minimum 70%, Missing); thymus: 26.3889% (minimum 65%, Missing); thyroid gland: 59.3750% (minimum 60%, Approved); urinary bladder: 57.5758% (minimum 65%, Approved)",-0.386111,-0.10625,-0.236585,0,1,partial,2.2,1.5,5.3,"thymus: 5.3 nTPM (manageable, limit 5); liver: 2.2 nTPM (vital, limit 2); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214226,C17orf67,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3750% (minimum 65%, Baseline (adaptation disabled)); amygdala: 65.5172% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.3704% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 67.8571% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 67.8571% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.0769% (minimum 75%, Baseline (adaptation disabled)); colon: 59.3750% (minimum 70%, Baseline (adaptation disabled)); duodenum: 73.0769% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 67.8571% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 57.5758% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.3704% (minimum 75%, Baseline (adaptation disabled)); liver: 46.3415% (minimum 75%, Baseline (adaptation disabled)); lung: 55.8824% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.8824% (minimum 70%, Baseline (adaptation disabled)); midbrain: 65.5172% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.2857% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 59.3750% (minimum 75%, Baseline (adaptation disabled)); retina: 70.3704% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 67.8571% (minimum 70%, Baseline (adaptation disabled)); small intestine: 54.2857% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 57.5758% (minimum 75%, Baseline (adaptation disabled)); spleen: 42.2222% (minimum 65%, Baseline (adaptation disabled)); stomach: 67.8571% (minimum 70%, Baseline (adaptation disabled)); thymus: 26.3889% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 59.3750% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 57.5758% (minimum 70%, Baseline (adaptation disabled))",-0.386111,-0.141176,-0.286585,0,1,partial,2.2,1.5,5.3,"thymus: 5.3 nTPM (manageable, limit 5); liver: 2.2 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214226,C17orf67,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6911% (minimum 95%, Missing); adrenal gland: 95.0931% (minimum 99%, Missing); amygdala: 95.7411% (minimum 99%, Missing); basal ganglia: 95.4160% (minimum 99%, Missing); bone marrow: 98.2517% (minimum 99%, Missing); cerebellum: 97.9094% (minimum 99%, Missing); cerebral cortex: 96.2329% (minimum 99%, Missing); choroid plexus: 70.6918% (minimum 99%, Missing); colon: 64.0821% (minimum 97%, Missing); duodenum: 71.4104% (minimum 99%, Missing); esophagus: 85.5403% (minimum 97%, Missing); heart muscle: 77.5172% (minimum 99%, Missing); hippocampal formation: 94.9324% (minimum 99%, Missing); hypothalamus: 95.9044% (minimum 99%, Missing); kidney: 76.0487% (minimum 99%, Missing); liver: 1.8881% (minimum 99%, Missing); lung: 75.7412% (minimum 99%, Missing); lymph node: 94.2953% (minimum 97%, Missing); midbrain: 95.0931% (minimum 99%, Missing); pancreas: 65.2729% (minimum 99%, Missing); parathyroid gland: 91.6803% (minimum 97%, Missing); pituitary gland: 92.1311% (minimum 99%, Missing); rectum: 55.9761% (minimum 97%, Missing); retina: 96.3979% (minimum 99%, Missing); salivary gland: 52.4254% (minimum 97%, Missing); skeletal muscle: 90.3537% (minimum 99%, Missing); skin: 67.9565% (minimum 95%, Missing); small intestine: 68.1212% (minimum 99%, Missing); smooth muscle: 84.7662% (minimum 99%, Missing); spinal cord: 93.5108% (minimum 99%, Missing); spleen: 88.6435% (minimum 95%, Missing); stomach: 49.8227% (minimum 97%, Missing); thyroid gland: 86.8624% (minimum 95%, Missing); tongue: 84.7662% (minimum 97%, Missing); urinary bladder: 70.0748% (minimum 97%, Missing)",-0.343089,-0.471773,-0.971119,0,80,unavailable,2920.4,56.6,36.4,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 2); salivary gland: 51 nTPM (protected, limit 2); rectum: 44.2 nTPM (protected, limit 2); adipose tissue: 36.4 nTPM (manageable, limit 5); colon: 31.5 nTPM (protected, limit 2); pancreas: 29.9 nTPM (vital, limit 1); skin: 26.5 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 2); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 2); esophagus: 9.5 nTPM (protected, limit 2); thyroid gland: 8.5 nTPM (manageable, limit 5); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 2); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214274,ANG,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6911% (minimum 65%, Missing); choroid plexus: 70.6918% (minimum 75%, Missing); colon: 64.0821% (minimum 70%, Missing); duodenum: 71.4104% (minimum 75%, Missing); liver: 1.8881% (minimum 75%, Missing); pancreas: 65.2729% (minimum 75%, Missing); rectum: 55.9761% (minimum 70%, Missing); salivary gland: 52.4254% (minimum 70%, Missing); small intestine: 68.1212% (minimum 75%, Missing); stomach: 49.8227% (minimum 70%, Missing)",-0.0430886,-0.201773,-0.731119,0,80,unavailable,2920.4,56.6,36.4,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 2); salivary gland: 51 nTPM (protected, limit 2); rectum: 44.2 nTPM (protected, limit 2); adipose tissue: 36.4 nTPM (manageable, limit 5); colon: 31.5 nTPM (protected, limit 2); pancreas: 29.9 nTPM (vital, limit 1); skin: 26.5 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 2); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 2); esophagus: 9.5 nTPM (protected, limit 2); thyroid gland: 8.5 nTPM (manageable, limit 5); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 2); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214274,ANG,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6911% (minimum 65%, Missing); choroid plexus: 70.6918% (minimum 75%, Missing); colon: 64.0821% (minimum 70%, Missing); duodenum: 71.4104% (minimum 75%, Missing); liver: 1.8881% (minimum 75%, Missing); pancreas: 65.2729% (minimum 75%, Missing); rectum: 55.9761% (minimum 70%, Missing); salivary gland: 52.4254% (minimum 70%, Missing); small intestine: 68.1212% (minimum 75%, Missing); stomach: 49.8227% (minimum 70%, Missing)",-0.0430886,-0.201773,-0.731119,0,80,unavailable,2920.4,56.6,36.4,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 3); salivary gland: 51 nTPM (protected, limit 3); rectum: 44.2 nTPM (protected, limit 3); adipose tissue: 36.4 nTPM (manageable, limit 5); colon: 31.5 nTPM (protected, limit 3); pancreas: 29.9 nTPM (vital, limit 1); skin: 26.5 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 3); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 3); esophagus: 9.5 nTPM (protected, limit 3); thyroid gland: 8.5 nTPM (manageable, limit 5); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 3); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214274,ANG,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6911% (minimum 65%, Missing); choroid plexus: 70.6918% (minimum 75%, Missing); colon: 64.0821% (minimum 70%, Missing); duodenum: 71.4104% (minimum 75%, Missing); liver: 1.8881% (minimum 75%, Missing); pancreas: 65.2729% (minimum 75%, Missing); rectum: 55.9761% (minimum 70%, Missing); salivary gland: 52.4254% (minimum 70%, Missing); small intestine: 68.1212% (minimum 75%, Missing); stomach: 49.8227% (minimum 70%, Missing)",-0.0430886,-0.201773,-0.731119,0,80,unavailable,2920.4,56.6,36.4,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 3); salivary gland: 51 nTPM (protected, limit 3); rectum: 44.2 nTPM (protected, limit 3); adipose tissue: 36.4 nTPM (manageable, limit 5); colon: 31.5 nTPM (protected, limit 3); pancreas: 29.9 nTPM (vital, limit 1); skin: 26.5 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 3); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 3); esophagus: 9.5 nTPM (protected, limit 3); thyroid gland: 8.5 nTPM (manageable, limit 5); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 3); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214274,ANG,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6911% (minimum 65%, Baseline (adaptation disabled)); choroid plexus: 70.6918% (minimum 75%, Baseline (adaptation disabled)); colon: 64.0821% (minimum 70%, Baseline (adaptation disabled)); duodenum: 71.4104% (minimum 75%, Baseline (adaptation disabled)); liver: 1.8881% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.2729% (minimum 75%, Baseline (adaptation disabled)); rectum: 55.9761% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 52.4254% (minimum 70%, Baseline (adaptation disabled)); small intestine: 68.1212% (minimum 75%, Baseline (adaptation disabled)); stomach: 49.8227% (minimum 70%, Baseline (adaptation disabled))",-0.0430886,-0.201773,-0.731119,0,80,unavailable,2920.4,56.6,36.4,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 3); salivary gland: 51 nTPM (protected, limit 3); rectum: 44.2 nTPM (protected, limit 3); adipose tissue: 36.4 nTPM (manageable, limit 5); colon: 31.5 nTPM (protected, limit 3); pancreas: 29.9 nTPM (vital, limit 1); skin: 26.5 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 3); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 3); esophagus: 9.5 nTPM (protected, limit 3); thyroid gland: 8.5 nTPM (manageable, limit 5); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 3); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214274,ANG,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.0000% (minimum 97%, Supported); cerebellum: 96.0000% (minimum 97%, Supported); kidney: 96.0000% (minimum 97%, Supported); liver: 96.0000% (minimum 97%, Supported); pituitary gland: 96.0000% (minimum 99%, Missing)",0.05,0.03,-0.03,0,3,partial,0.1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214300,SPDYE3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.35,0.3,0.21,0,3,partial,0.1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214300,SPDYE3,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.35,0.3,0.21,0,3,partial,0.1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214300,SPDYE3,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.35,0.3,0.21,0,3,partial,0.1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214300,SPDYE3,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.31,0.26,0.21,0,3,partial,0.1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214300,SPDYE3,current_fixed,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214324,PRR23E,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive noncoding;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214324,PRR23E,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive noncoding;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214324,PRR23E,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive noncoding;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214324,PRR23E,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive noncoding;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214324,PRR23E,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive noncoding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.3333% (minimum 95%, Missing); adrenal gland: 42.3077% (minimum 99%, Missing); amygdala: 64.7059% (minimum 99%, Missing); basal ganglia: 78.5714% (minimum 99%, Missing); bone marrow: 78.5714% (minimum 99%, Missing); cerebellum: 73.3333% (minimum 99%, Missing); cerebral cortex: 12.0879% (minimum 99%, Missing); choroid plexus: 73.3333% (minimum 99%, Missing); colon: 64.7059% (minimum 97%, Missing); duodenum: 64.7059% (minimum 99%, Missing); esophagus: 47.8261% (minimum 97%, Missing); heart muscle: 78.5714% (minimum 99%, Missing); hippocampal formation: 61.1111% (minimum 99%, Missing); hypothalamus: 61.1111% (minimum 99%, Missing); kidney: 84.6154% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 32.3529% (minimum 99%, Missing); lymph node: 68.7500% (minimum 97%, Missing); midbrain: 37.9310% (minimum 99%, Missing); pancreas: 55.0000% (minimum 99%, Missing); pituitary gland: 36.6667% (minimum 99%, Missing); rectum: 64.7059% (minimum 97%, Missing); retina: 25.0000% (minimum 99%, Missing); salivary gland: 68.7500% (minimum 97%, Missing); skeletal muscle: 78.5714% (minimum 99%, Missing); skin: 64.7059% (minimum 95%, Missing); small intestine: 47.8261% (minimum 99%, Missing); smooth muscle: 78.5714% (minimum 99%, Missing); spinal cord: 23.4043% (minimum 99%, Missing); spleen: 52.3810% (minimum 95%, Missing); stomach: 33.3333% (minimum 97%, Missing); thymus: 91.6667% (minimum 95%, Missing); thyroid gland: 55.0000% (minimum 95%, Missing); tongue: 84.6154% (minimum 97%, Missing); urinary bladder: 64.7059% (minimum 97%, Missing)",-0.42619,-0.636667,-0.869121,0,80,unavailable,8,2.2,1,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214338,MTCL3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 42.3077% (minimum 75%, Missing); amygdala: 64.7059% (minimum 75%, Missing); cerebellum: 73.3333% (minimum 75%, Missing); cerebral cortex: 12.0879% (minimum 75%, Missing); choroid plexus: 73.3333% (minimum 75%, Missing); colon: 64.7059% (minimum 70%, Missing); duodenum: 64.7059% (minimum 75%, Missing); esophagus: 47.8261% (minimum 70%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 61.1111% (minimum 75%, Missing); lung: 32.3529% (minimum 75%, Missing); lymph node: 68.7500% (minimum 70%, Missing); midbrain: 37.9310% (minimum 75%, Missing); pancreas: 55.0000% (minimum 75%, Missing); pituitary gland: 36.6667% (minimum 75%, Missing); rectum: 64.7059% (minimum 70%, Missing); retina: 25.0000% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skin: 64.7059% (minimum 65%, Missing); small intestine: 47.8261% (minimum 75%, Missing); spinal cord: 23.4043% (minimum 75%, Missing); spleen: 52.3810% (minimum 65%, Missing); stomach: 33.3333% (minimum 70%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); urinary bladder: 64.7059% (minimum 70%, Missing)",-0.12619,-0.366667,-0.629121,0,80,unavailable,8,2.2,1,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214338,MTCL3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 42.3077% (minimum 75%, Missing); amygdala: 64.7059% (minimum 75%, Missing); cerebellum: 73.3333% (minimum 75%, Missing); cerebral cortex: 12.0879% (minimum 75%, Missing); choroid plexus: 73.3333% (minimum 75%, Missing); colon: 64.7059% (minimum 70%, Missing); duodenum: 64.7059% (minimum 75%, Missing); esophagus: 47.8261% (minimum 70%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 61.1111% (minimum 75%, Missing); lung: 32.3529% (minimum 75%, Missing); lymph node: 68.7500% (minimum 70%, Missing); midbrain: 37.9310% (minimum 75%, Missing); pancreas: 55.0000% (minimum 75%, Missing); pituitary gland: 36.6667% (minimum 75%, Missing); rectum: 64.7059% (minimum 70%, Missing); retina: 25.0000% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skin: 64.7059% (minimum 65%, Missing); small intestine: 47.8261% (minimum 75%, Missing); spinal cord: 23.4043% (minimum 75%, Missing); spleen: 52.3810% (minimum 65%, Missing); stomach: 33.3333% (minimum 70%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); urinary bladder: 64.7059% (minimum 70%, Missing)",-0.12619,-0.366667,-0.629121,0,80,unavailable,8,2.2,1,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214338,MTCL3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 42.3077% (minimum 75%, Missing); amygdala: 64.7059% (minimum 75%, Missing); cerebellum: 73.3333% (minimum 75%, Missing); cerebral cortex: 12.0879% (minimum 75%, Missing); choroid plexus: 73.3333% (minimum 75%, Missing); colon: 64.7059% (minimum 70%, Missing); duodenum: 64.7059% (minimum 75%, Missing); esophagus: 47.8261% (minimum 70%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 61.1111% (minimum 75%, Missing); lung: 32.3529% (minimum 75%, Missing); lymph node: 68.7500% (minimum 70%, Missing); midbrain: 37.9310% (minimum 75%, Missing); pancreas: 55.0000% (minimum 75%, Missing); pituitary gland: 36.6667% (minimum 75%, Missing); rectum: 64.7059% (minimum 70%, Missing); retina: 25.0000% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skin: 64.7059% (minimum 65%, Missing); small intestine: 47.8261% (minimum 75%, Missing); spinal cord: 23.4043% (minimum 75%, Missing); spleen: 52.3810% (minimum 65%, Missing); stomach: 33.3333% (minimum 70%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); urinary bladder: 64.7059% (minimum 70%, Missing)",-0.12619,-0.366667,-0.629121,0,80,unavailable,8,2.2,1,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214338,MTCL3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 42.3077% (minimum 75%, Baseline (adaptation disabled)); amygdala: 64.7059% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.3333% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 12.0879% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 73.3333% (minimum 75%, Baseline (adaptation disabled)); colon: 64.7059% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.7059% (minimum 75%, Baseline (adaptation disabled)); esophagus: 47.8261% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 61.1111% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.1111% (minimum 75%, Baseline (adaptation disabled)); lung: 32.3529% (minimum 75%, Baseline (adaptation disabled)); lymph node: 68.7500% (minimum 70%, Baseline (adaptation disabled)); midbrain: 37.9310% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 36.6667% (minimum 75%, Baseline (adaptation disabled)); rectum: 64.7059% (minimum 70%, Baseline (adaptation disabled)); retina: 25.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.7500% (minimum 70%, Baseline (adaptation disabled)); skin: 64.7059% (minimum 65%, Baseline (adaptation disabled)); small intestine: 47.8261% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 23.4043% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.3810% (minimum 65%, Baseline (adaptation disabled)); stomach: 33.3333% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 55.0000% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 64.7059% (minimum 70%, Baseline (adaptation disabled))",-0.12619,-0.366667,-0.629121,0,80,unavailable,8,2.2,1,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214338,MTCL3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 97.9798% (minimum 99%, Missing)",0.05,0.03,-0.010202,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214360,EFCAB9,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.229798,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214360,EFCAB9,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.229798,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214360,EFCAB9,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.229798,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214360,EFCAB9,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.229798,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214360,EFCAB9,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 15.0000% (minimum 99%, Missing); small intestine: 20.0000% (minimum 99%, Missing)",0,0.03,-0.84,0,10,partial,1.7,0,0.2,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214415,GNAT3,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 15.0000% (minimum 75%, Missing); small intestine: 20.0000% (minimum 75%, Missing)",0.1,0.3,-0.6,0,10,partial,1.7,0,0.2,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214415,GNAT3,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 15.0000% (minimum 75%, Missing); small intestine: 20.0000% (minimum 75%, Missing)",0.1,0.3,-0.6,0,10,partial,1.7,0,0.2,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214415,GNAT3,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 15.0000% (minimum 75%, Missing); small intestine: 20.0000% (minimum 75%, Missing)",0.1,0.3,-0.6,0,10,partial,1.7,0,0.2,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214415,GNAT3,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Baseline (adaptation disabled)); duodenum: 15.0000% (minimum 75%, Baseline (adaptation disabled)); small intestine: 20.0000% (minimum 75%, Baseline (adaptation disabled))",-0.05,0.3,-0.6,0,10,partial,1.7,0,0.2,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214415,GNAT3,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 50.0000% (minimum 95%, Missing); bone marrow: 75.0000% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); liver: 33.3333% (minimum 99%, Missing); lung: 60.0000% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); pancreas: 27.2727% (minimum 99%, Missing); parathyroid gland: 50.0000% (minimum 97%, Missing); pituitary gland: 75.0000% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 60.0000% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 97%, Missing); skeletal muscle: 42.8571% (minimum 99%, Missing); skin: 42.8571% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 60.0000% (minimum 99%, Missing); spleen: 60.0000% (minimum 95%, Missing); stomach: 42.8571% (minimum 97%, Missing); thyroid gland: 42.8571% (minimum 95%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",-0.521429,-0.541429,-0.717273,0,80,unavailable,0.8,0.4,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214511,HIGD1C,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); bone marrow: 75.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); liver: 33.3333% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 27.2727% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 75.0000% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 42.8571% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 75.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thyroid gland: 42.8571% (minimum 65%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.221429,-0.271429,-0.477273,0,80,unavailable,0.8,0.4,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214511,HIGD1C,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); bone marrow: 75.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); liver: 33.3333% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 27.2727% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 75.0000% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 42.8571% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 75.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thyroid gland: 42.8571% (minimum 65%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.221429,-0.271429,-0.477273,0,80,unavailable,0.8,0.4,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214511,HIGD1C,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); bone marrow: 75.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); liver: 33.3333% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 27.2727% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 75.0000% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 42.8571% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 75.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thyroid gland: 42.8571% (minimum 65%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.221429,-0.271429,-0.477273,0,80,unavailable,0.8,0.4,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214511,HIGD1C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 75.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 33.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 60.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 27.2727% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 50.0000% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 75.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 60.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 42.8571% (minimum 75%, Baseline (adaptation disabled)); skin: 42.8571% (minimum 65%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 42.8571% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 42.8571% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 70%, Baseline (adaptation disabled))",-0.221429,-0.271429,-0.477273,0,80,unavailable,0.8,0.4,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214511,HIGD1C,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214681,IQCF5,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214681,IQCF5,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214681,IQCF5,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214681,IQCF5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214681,IQCF5,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 98.5849% (minimum 99%, Missing)",0.05,0.0252381,-0.00415094,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214686,IQCF6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.295238,0.235849,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214686,IQCF6,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.295238,0.235849,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214686,IQCF6,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.295238,0.235849,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214686,IQCF6,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.295238,0.235849,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214686,IQCF6,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"duodenum: 24.2678% (minimum 99%, Missing); retina: 98.3051% (minimum 99%, Missing); small intestine: 65.9091% (minimum 99%, Missing)",0.05,0.0166667,-0.747322,0,3,partial,18.1,0.2,0,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),53,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214782,MS4A18,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"duodenum: 24.2678% (minimum 75%, Missing); small intestine: 65.9091% (minimum 75%, Missing)",0.35,0.3,-0.507322,0,3,partial,18.1,0.2,0,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),53,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214782,MS4A18,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"duodenum: 24.2678% (minimum 75%, Missing); small intestine: 65.9091% (minimum 75%, Missing)",0.35,0.3,-0.507322,0,3,partial,18.1,0.2,0,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),53,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214782,MS4A18,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"duodenum: 24.2678% (minimum 75%, Missing); small intestine: 65.9091% (minimum 75%, Missing)",0.35,0.3,-0.507322,0,3,partial,18.1,0.2,0,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),53,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214782,MS4A18,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"duodenum: 24.2678% (minimum 75%, Baseline (adaptation disabled)); small intestine: 65.9091% (minimum 75%, Baseline (adaptation disabled))",0.35,0.266667,-0.507322,0,3,partial,18.1,0.2,0,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),53,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214782,MS4A18,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 32.8767% (minimum 97%, Missing); duodenum: 46.1538% (minimum 99%, Missing); kidney: 43.6364% (minimum 95%, Enhanced); rectum: 18.7500% (minimum 97%, Missing); skeletal muscle: 96.0000% (minimum 99%, Missing); small intestine: 35.2941% (minimum 99%, Missing); stomach: 5.4054% (minimum 97%, Missing); thyroid gland: 52.1739% (minimum 95%, Missing)",-0.428261,-0.915946,-0.637059,0,9,partial,4.4,42,2.2,"stomach: 42 nTPM (protected, limit 2); rectum: 10.4 nTPM (protected, limit 2); colon: 4.9 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),70,not_established,required,in_situ_inflammation_review,appendix; appendix / goblet cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214814,FER1L6,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 32.8767% (minimum 70%, Missing); duodenum: 46.1538% (minimum 75%, Missing); kidney: 43.6364% (minimum 60%, Enhanced); rectum: 18.7500% (minimum 70%, Missing); small intestine: 35.2941% (minimum 75%, Missing); stomach: 5.4054% (minimum 70%, Missing); thyroid gland: 52.1739% (minimum 65%, Missing)",-0.128261,-0.645946,-0.397059,0,9,partial,4.4,42,2.2,"stomach: 42 nTPM (protected, limit 2); rectum: 10.4 nTPM (protected, limit 2); colon: 4.9 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),70,not_established,required,in_situ_inflammation_review,appendix; appendix / goblet cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214814,FER1L6,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 32.8767% (minimum 70%, Missing); duodenum: 46.1538% (minimum 75%, Missing); kidney: 43.6364% (minimum 60%, Enhanced); rectum: 18.7500% (minimum 70%, Missing); small intestine: 35.2941% (minimum 75%, Missing); stomach: 5.4054% (minimum 70%, Missing); thyroid gland: 52.1739% (minimum 65%, Missing)",-0.128261,-0.645946,-0.397059,0,9,partial,4.4,42,2.2,"stomach: 42 nTPM (protected, limit 3); rectum: 10.4 nTPM (protected, limit 3); colon: 4.9 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),70,not_established,required,in_situ_inflammation_review,appendix; appendix / goblet cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214814,FER1L6,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 32.8767% (minimum 70%, Missing); duodenum: 46.1538% (minimum 75%, Missing); kidney: 43.6364% (minimum 60%, Enhanced); rectum: 18.7500% (minimum 70%, Missing); small intestine: 35.2941% (minimum 75%, Missing); stomach: 5.4054% (minimum 70%, Missing); thyroid gland: 52.1739% (minimum 65%, Missing)",-0.128261,-0.645946,-0.397059,0,9,partial,4.4,42,2.2,"stomach: 42 nTPM (protected, limit 3); rectum: 10.4 nTPM (protected, limit 3); colon: 4.9 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),70,not_established,required,in_situ_inflammation_review,appendix; appendix / goblet cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214814,FER1L6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 32.8767% (minimum 70%, Baseline (adaptation disabled)); duodenum: 46.1538% (minimum 75%, Baseline (adaptation disabled)); kidney: 43.6364% (minimum 75%, Baseline (adaptation disabled)); rectum: 18.7500% (minimum 70%, Baseline (adaptation disabled)); small intestine: 35.2941% (minimum 75%, Baseline (adaptation disabled)); stomach: 5.4054% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 52.1739% (minimum 65%, Baseline (adaptation disabled))",-0.128261,-0.645946,-0.397059,0,9,partial,4.4,42,2.2,"stomach: 42 nTPM (protected, limit 3); rectum: 10.4 nTPM (protected, limit 3); colon: 4.9 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),70,not_established,required,in_situ_inflammation_review,appendix; appendix / goblet cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214814,FER1L6,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hippocampal formation: 87.2832% (minimum 99%, Missing)",0.05,0.0234211,-0.117168,0,80,unavailable,2.2,0.1,0,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214819,CDRT15L2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293421,0.122832,0,80,unavailable,2.2,0.1,0,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214819,CDRT15L2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293421,0.122832,0,80,unavailable,2.2,0.1,0,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214819,CDRT15L2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293421,0.122832,0,80,unavailable,2.2,0.1,0,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214819,CDRT15L2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293421,0.122832,0,80,unavailable,2.2,0.1,0,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214819,CDRT15L2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.9130% (minimum 99%, Missing); cerebellum: 97.8495% (minimum 99%, Missing); cerebral cortex: 96.8085% (minimum 99%, Missing); heart muscle: 97.8495% (minimum 99%, Missing); hippocampal formation: 98.9130% (minimum 99%, Missing); hypothalamus: 98.9130% (minimum 99%, Missing); liver: 97.8495% (minimum 99%, Missing); pancreas: 97.8495% (minimum 99%, Missing)",0.0391304,0.00849462,-0.0219149,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214842,RAD51AP2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.33913,0.278495,0.218085,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214842,RAD51AP2,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.33913,0.278495,0.218085,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214842,RAD51AP2,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.33913,0.278495,0.218085,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214842,RAD51AP2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.33913,0.278495,0.218085,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214842,RAD51AP2,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.9091% (minimum 99%, Missing); choroid plexus: 76.9231% (minimum 99%, Missing); lung: 97.5610% (minimum 99%, Missing); pituitary gland: 97.5610% (minimum 99%, Missing); retina: 93.0233% (minimum 99%, Missing); skeletal muscle: 95.2381% (minimum 99%, Missing)",0.00238095,0.00560976,-0.220769,0,80,unavailable,1.2,0.1,0.2,"choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214866,DCDC2C,admission_only,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302381,0.27561,0.0192308,0,80,unavailable,1.2,0.1,0.2,"choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214866,DCDC2C,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302381,0.27561,0.0192308,0,80,unavailable,1.2,0.1,0.2,"choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214866,DCDC2C,grid_revised,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302381,0.27561,0.0192308,0,80,unavailable,1.2,0.1,0.2,"choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214866,DCDC2C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302381,0.27561,0.0192308,0,80,unavailable,1.2,0.1,0.2,"choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214866,DCDC2C,current_fixed,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 98.3051% (minimum 99%, Missing); pituitary gland: 97.4790% (minimum 99%, Missing)",0.041453,0.03,-0.0152101,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214897,PNMA6E,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.341453,0.3,0.22479,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214897,PNMA6E,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.341453,0.3,0.22479,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214897,PNMA6E,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.341453,0.3,0.22479,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214897,PNMA6E,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.341453,0.3,0.22479,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000214897,PNMA6E,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214929,SPATA31D1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214929,SPATA31D1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214929,SPATA31D1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214929,SPATA31D1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214929,SPATA31D1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 89.0173% (minimum 99%, Missing); basal ganglia: 78.5714% (minimum 99%, Missing); cerebellum: 98.7179% (minimum 99%, Missing); cerebral cortex: 92.7711% (minimum 99%, Missing); hippocampal formation: 83.6957% (minimum 99%, Missing); hypothalamus: 97.4684% (minimum 99%, Missing); midbrain: 97.4684% (minimum 99%, Missing); pituitary gland: 98.7179% (minimum 99%, Missing); spinal cord: 97.4684% (minimum 99%, Missing)",0.0435484,0.0235484,-0.204286,0,80,unavailable,4.2,0.1,0.1,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214946,TBC1D26,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343548,0.293548,0.0357143,0,80,unavailable,4.2,0.1,0.1,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214946,TBC1D26,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343548,0.293548,0.0357143,0,80,unavailable,4.2,0.1,0.1,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214946,TBC1D26,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343548,0.293548,0.0357143,0,80,unavailable,4.2,0.1,0.1,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214946,TBC1D26,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343548,0.293548,0.0357143,0,80,unavailable,4.2,0.1,0.1,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000214946,TBC1D26,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 88.8889% (minimum 95%, Missing); adrenal gland: 88.8889% (minimum 99%, Missing); cerebral cortex: 88.8889% (minimum 99%, Missing); duodenum: 80.0000% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); small intestine: 72.7273% (minimum 99%, Missing); spleen: 61.5385% (minimum 95%, Missing)",-0.334615,-0.0811111,-0.323333,0,80,unavailable,0.4,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215009,ACSM4,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); spleen: 61.5385% (minimum 65%, Missing)",-0.0346154,0.188889,-0.0833333,0,80,unavailable,0.4,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215009,ACSM4,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); spleen: 61.5385% (minimum 65%, Missing)",-0.0346154,0.188889,-0.0833333,0,80,unavailable,0.4,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215009,ACSM4,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); spleen: 61.5385% (minimum 65%, Missing)",-0.0346154,0.188889,-0.0833333,0,80,unavailable,0.4,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215009,ACSM4,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.7273% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.5385% (minimum 65%, Baseline (adaptation disabled))",-0.0346154,0.188889,-0.0833333,0,80,unavailable,0.4,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215009,ACSM4,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215113,CXorf49B,admission_only,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215113,CXorf49B,selectivity_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215113,CXorf49B,grid_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215113,CXorf49B,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215113,CXorf49B,current_fixed,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215115,CXorf49,admission_only,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215115,CXorf49,selectivity_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215115,CXorf49,grid_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215115,CXorf49,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215115,CXorf49,current_fixed,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8140% (minimum 90%, Approved); adrenal gland: 32.0000% (minimum 99%, Missing); amygdala: 53.3333% (minimum 99%, Missing); basal ganglia: 61.5385% (minimum 99%, Missing); bone marrow: 52.1739% (minimum 98%, Approved); cerebellum: 68.5714% (minimum 99%, Missing); cerebral cortex: 58.5366% (minimum 99%, Missing); choroid plexus: 85.7143% (minimum 99%, Missing); colon: 57.1429% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 46.1538% (minimum 97%, Missing); heart muscle: 42.8571% (minimum 99%, Missing); hippocampal formation: 66.6667% (minimum 99%, Missing); hypothalamus: 55.8140% (minimum 99%, Missing); kidney: 42.1053% (minimum 99%, Missing); liver: 25.2632% (minimum 99%, Missing); lung: 55.8140% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); midbrain: 54.5455% (minimum 99%, Missing); pancreas: 42.1053% (minimum 99%, Missing); parathyroid gland: 92.3077% (minimum 97%, Missing); pituitary gland: 48.0000% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 58.5366% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing); skeletal muscle: 40.6780% (minimum 98%, Approved); skin: 63.1579% (minimum 95%, Missing); small intestine: 57.1429% (minimum 99%, Missing); smooth muscle: 82.7586% (minimum 98%, Approved); spinal cord: 53.3333% (minimum 99%, Missing); spleen: 54.5455% (minimum 95%, Missing); stomach: 52.1739% (minimum 97%, Missing); thymus: 88.8889% (minimum 95%, Missing); thyroid gland: 53.3333% (minimum 95%, Missing); urinary bladder: 68.5714% (minimum 97%, Missing)",-0.416667,-0.508462,-0.737368,0,7,partial,7.1,2.8,2.1,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 2); spinal cord: 2.1 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215126,ZNG1F,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8140% (minimum 60%, Approved); adrenal gland: 32.0000% (minimum 75%, Missing); amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 61.5385% (minimum 75%, Missing); bone marrow: 52.1739% (minimum 70%, Approved); cerebellum: 68.5714% (minimum 75%, Missing); cerebral cortex: 58.5366% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 46.1538% (minimum 70%, Missing); heart muscle: 42.8571% (minimum 75%, Missing); hippocampal formation: 66.6667% (minimum 75%, Missing); hypothalamus: 55.8140% (minimum 75%, Missing); kidney: 42.1053% (minimum 75%, Missing); liver: 25.2632% (minimum 75%, Missing); lung: 55.8140% (minimum 75%, Missing); midbrain: 54.5455% (minimum 75%, Missing); pancreas: 42.1053% (minimum 75%, Missing); pituitary gland: 48.0000% (minimum 75%, Missing); retina: 58.5366% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 40.6780% (minimum 70%, Approved); skin: 63.1579% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); spinal cord: 53.3333% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 52.1739% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 68.5714% (minimum 70%, Missing)",-0.116667,-0.238462,-0.497368,0,7,partial,7.1,2.8,2.1,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 2); spinal cord: 2.1 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215126,ZNG1F,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8140% (minimum 60%, Approved); adrenal gland: 32.0000% (minimum 75%, Missing); amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 61.5385% (minimum 75%, Missing); bone marrow: 52.1739% (minimum 70%, Approved); cerebellum: 68.5714% (minimum 75%, Missing); cerebral cortex: 58.5366% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 46.1538% (minimum 70%, Missing); heart muscle: 42.8571% (minimum 75%, Missing); hippocampal formation: 66.6667% (minimum 75%, Missing); hypothalamus: 55.8140% (minimum 75%, Missing); kidney: 42.1053% (minimum 75%, Missing); liver: 25.2632% (minimum 75%, Missing); lung: 55.8140% (minimum 75%, Missing); midbrain: 54.5455% (minimum 75%, Missing); pancreas: 42.1053% (minimum 75%, Missing); pituitary gland: 48.0000% (minimum 75%, Missing); retina: 58.5366% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 40.6780% (minimum 70%, Approved); skin: 63.1579% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); spinal cord: 53.3333% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 52.1739% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 68.5714% (minimum 70%, Missing)",-0.116667,-0.238462,-0.497368,0,7,partial,7.1,2.8,2.1,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); amygdala: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215126,ZNG1F,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8140% (minimum 60%, Approved); adrenal gland: 32.0000% (minimum 75%, Missing); amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 61.5385% (minimum 75%, Missing); bone marrow: 52.1739% (minimum 70%, Approved); cerebellum: 68.5714% (minimum 75%, Missing); cerebral cortex: 58.5366% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 46.1538% (minimum 70%, Missing); heart muscle: 42.8571% (minimum 75%, Missing); hippocampal formation: 66.6667% (minimum 75%, Missing); hypothalamus: 55.8140% (minimum 75%, Missing); kidney: 42.1053% (minimum 75%, Missing); liver: 25.2632% (minimum 75%, Missing); lung: 55.8140% (minimum 75%, Missing); midbrain: 54.5455% (minimum 75%, Missing); pancreas: 42.1053% (minimum 75%, Missing); pituitary gland: 48.0000% (minimum 75%, Missing); retina: 58.5366% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 40.6780% (minimum 70%, Approved); skin: 63.1579% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); spinal cord: 53.3333% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 52.1739% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 68.5714% (minimum 70%, Missing)",-0.116667,-0.238462,-0.497368,0,7,partial,7.1,2.8,2.1,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); amygdala: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215126,ZNG1F,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8140% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 32.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 53.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.5385% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 52.1739% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.5714% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.5366% (minimum 75%, Baseline (adaptation disabled)); colon: 57.1429% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); esophagus: 46.1538% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 42.8571% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 66.6667% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.8140% (minimum 75%, Baseline (adaptation disabled)); kidney: 42.1053% (minimum 75%, Baseline (adaptation disabled)); liver: 25.2632% (minimum 75%, Baseline (adaptation disabled)); lung: 55.8140% (minimum 75%, Baseline (adaptation disabled)); midbrain: 54.5455% (minimum 75%, Baseline (adaptation disabled)); pancreas: 42.1053% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 48.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 58.5366% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 40.6780% (minimum 75%, Baseline (adaptation disabled)); skin: 63.1579% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.1429% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.3333% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.5455% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.1739% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 53.3333% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 68.5714% (minimum 70%, Baseline (adaptation disabled))",-0.116667,-0.238462,-0.497368,0,7,partial,7.1,2.8,2.1,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215126,ZNG1F,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.00787686,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215131,C16orf90,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247877,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215131,C16orf90,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247877,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215131,C16orf90,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247877,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215131,C16orf90,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.247877,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215131,C16orf90,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 92.3077% (minimum 99%, Missing); salivary gland: 75.0000% (minimum 97%, Missing); stomach: 80.0000% (minimum 97%, Missing)",0.05,-0.22,-0.0669231,0,80,unavailable,0.1,0.4,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215148,PRSS41,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.05,0.173077,0,80,unavailable,0.1,0.4,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215148,PRSS41,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.05,0.173077,0,80,unavailable,0.1,0.4,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215148,PRSS41,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.05,0.173077,0,80,unavailable,0.1,0.4,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215148,PRSS41,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.05,0.173077,0,80,unavailable,0.1,0.4,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215148,PRSS41,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 62.5000% (minimum 97%, Supported); retina: 94.5946% (minimum 99%, Missing); skeletal muscle: 95.8904% (minimum 97%, Supported)",0.05,0.03,-0.345,0,1,partial,4.2,0,0.2,"liver: 4.2 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215186,GOLGA6B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 62.5000% (minimum 65%, Supported)",0.35,0.3,-0.025,0,1,partial,4.2,0,0.2,"liver: 4.2 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215186,GOLGA6B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 62.5000% (minimum 65%, Supported)",0.35,0.3,-0.025,0,1,partial,4.2,0,0.2,"liver: 4.2 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215186,GOLGA6B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 62.5000% (minimum 65%, Supported)",0.35,0.3,-0.025,0,1,partial,4.2,0,0.2,"liver: 4.2 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215186,GOLGA6B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 62.5000% (minimum 75%, Baseline (adaptation disabled))",0.322222,0.3,-0.125,0,1,partial,4.2,0,0.2,"liver: 4.2 nTPM (vital, limit 1)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215186,GOLGA6B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"thymus: 88.8889% (minimum 95%, Missing)",-0.0611111,0.03,0.01,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215203,GRXCR1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.238889,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215203,GRXCR1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.238889,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215203,GRXCR1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.238889,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215203,GRXCR1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.238889,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215203,GRXCR1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.5507% (minimum 99%, Missing)",0.05,0.03,-0.00449275,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215262,KCNU1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235507,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215262,KCNU1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235507,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215262,KCNU1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235507,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215262,KCNU1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.235507,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215262,KCNU1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.3633% (minimum 99%, Missing)",0.05,0.0106061,-0.00636661,0,4,partial,1,5.9,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215269,GAGE12G,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.233633,0,4,partial,1,5.9,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215269,GAGE12G,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.233633,0,4,partial,1,5.9,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215269,GAGE12G,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.233633,0,4,partial,1,5.9,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215269,GAGE12G,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.210606,0.233633,0,4,partial,1,5.9,0,"stomach: 5.9 nTPM (protected, limit 3)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215269,GAGE12G,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 88.8889% (minimum 99%, Missing); basal ganglia: 76.1905% (minimum 99%, Missing); cerebellum: 88.8889% (minimum 97%, Supported); cerebral cortex: 94.1176% (minimum 97%, Supported); choroid plexus: 84.2105% (minimum 99%, Missing); colon: 94.1176% (minimum 97%, Missing); heart muscle: 94.1176% (minimum 97%, Supported); hippocampal formation: 94.1176% (minimum 99%, Missing); hypothalamus: 94.1176% (minimum 99%, Missing); midbrain: 94.1176% (minimum 99%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); retina: 76.1905% (minimum 99%, Missing); skeletal muscle: 94.1176% (minimum 97%, Supported); small intestine: 94.1176% (minimum 97%, Supported); smooth muscle: 88.8889% (minimum 97%, Supported); spinal cord: 94.1176% (minimum 99%, Missing)",0.05,-0.0288235,-0.323333,0,4,partial,0.8,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215274,GAGE10,admission_only,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 66.6667% (minimum 75%, Missing)",0.338889,0.241176,-0.0833333,0,4,partial,0.8,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215274,GAGE10,selectivity_revised,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 66.6667% (minimum 75%, Missing)",0.338889,0.241176,-0.0833333,0,4,partial,0.8,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215274,GAGE10,grid_revised,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 66.6667% (minimum 75%, Missing)",0.338889,0.241176,-0.0833333,0,4,partial,0.8,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215274,GAGE10,current_adaptive,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.238889,0.241176,-0.0833333,0,4,partial,0.8,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215274,GAGE10,current_fixed,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 98.1132% (minimum 99%, Missing); kidney: 17.2185% (minimum 99%, Missing); liver: 98.1132% (minimum 99%, Missing); lymph node: 96.2963% (minimum 97%, Missing); retina: 92.8571% (minimum 99%, Missing); small intestine: 98.1132% (minimum 99%, Missing); stomach: 96.2963% (minimum 97%, Missing); thyroid gland: 92.8571% (minimum 95%, Missing)",-0.0214286,-0.00703704,-0.817815,0,80,unavailable,25,0.2,0.4,"kidney: 25 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215277,RNF212B,admission_only,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 17.2185% (minimum 75%, Missing)",0.278571,0.262963,-0.577815,0,80,unavailable,25,0.2,0.4,"kidney: 25 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215277,RNF212B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 17.2185% (minimum 75%, Missing)",0.278571,0.262963,-0.577815,0,80,unavailable,25,0.2,0.4,"kidney: 25 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215277,RNF212B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 17.2185% (minimum 75%, Missing)",0.278571,0.262963,-0.577815,0,80,unavailable,25,0.2,0.4,"kidney: 25 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215277,RNF212B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 17.2185% (minimum 75%, Baseline (adaptation disabled))",0.278571,0.262963,-0.577815,0,80,unavailable,25,0.2,0.4,"kidney: 25 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215277,RNF212B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215343,ZNF705D,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215343,ZNF705D,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215343,ZNF705D,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215343,ZNF705D,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215343,ZNF705D,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215356,ZNF705B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215356,ZNF705B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215356,ZNF705B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215356,ZNF705B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215356,ZNF705B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"retina: 85.7143% (minimum 99%, Missing)",0.05,0.03,-0.132857,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215372,ZNF705G,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.107143,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215372,ZNF705G,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.107143,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215372,ZNF705G,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.107143,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215372,ZNF705G,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.107143,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215372,ZNF705G,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.4068% (minimum 95%, Uncertain); adrenal gland: 67.8571% (minimum 99%, Missing); amygdala: 77.5510% (minimum 99%, Missing); basal ganglia: 74.5098% (minimum 99%, Missing); bone marrow: 42.6966% (minimum 99%, Missing); cerebellum: 64.4068% (minimum 99%, Missing); cerebral cortex: 63.3333% (minimum 99%, Missing); choroid plexus: 76.0000% (minimum 99%, Missing); colon: 58.4615% (minimum 97%, Missing); duodenum: 65.5172% (minimum 99%, Missing); esophagus: 62.2951% (minimum 97%, Missing); heart muscle: 55.8824% (minimum 99%, Missing); hippocampal formation: 77.5510% (minimum 99%, Missing); hypothalamus: 79.1667% (minimum 99%, Missing); kidney: 63.3333% (minimum 99%, Missing); liver: 64.4068% (minimum 99%, Missing); lung: 63.3333% (minimum 99%, Missing); lymph node: 55.0725% (minimum 97%, Missing); midbrain: 79.1667% (minimum 99%, Missing); pancreas: 65.5172% (minimum 99%, Missing); parathyroid gland: 51.3514% (minimum 97%, Missing); pituitary gland: 71.6981% (minimum 99%, Missing); rectum: 64.4068% (minimum 97%, Missing); retina: 58.4615% (minimum 99%, Missing); salivary gland: 63.3333% (minimum 97%, Missing); skeletal muscle: 50.0000% (minimum 99%, Missing); skin: 63.3333% (minimum 95%, Missing); small intestine: 63.3333% (minimum 99%, Missing); smooth muscle: 56.7164% (minimum 99%, Missing); spinal cord: 74.5098% (minimum 99%, Missing); spleen: 54.2857% (minimum 95%, Missing); stomach: 64.4068% (minimum 97%, Missing); thymus: 43.1818% (minimum 95%, Missing); thyroid gland: 52.7778% (minimum 95%, Missing); tongue: 54.2857% (minimum 97%, Missing); urinary bladder: 62.2951% (minimum 97%, Missing)",-0.518182,-0.456486,-0.563034,0,5,partial,5.1,3.6,5,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215421,ZNF407,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.4068% (minimum 65%, Uncertain); adrenal gland: 67.8571% (minimum 75%, Missing); basal ganglia: 74.5098% (minimum 75%, Missing); bone marrow: 42.6966% (minimum 75%, Missing); cerebellum: 64.4068% (minimum 75%, Missing); cerebral cortex: 63.3333% (minimum 75%, Missing); colon: 58.4615% (minimum 70%, Missing); duodenum: 65.5172% (minimum 75%, Missing); esophagus: 62.2951% (minimum 70%, Missing); heart muscle: 55.8824% (minimum 75%, Missing); kidney: 63.3333% (minimum 75%, Missing); liver: 64.4068% (minimum 75%, Missing); lung: 63.3333% (minimum 75%, Missing); lymph node: 55.0725% (minimum 70%, Missing); pancreas: 65.5172% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 71.6981% (minimum 75%, Missing); rectum: 64.4068% (minimum 70%, Missing); retina: 58.4615% (minimum 75%, Missing); salivary gland: 63.3333% (minimum 70%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); skin: 63.3333% (minimum 65%, Missing); small intestine: 63.3333% (minimum 75%, Missing); smooth muscle: 56.7164% (minimum 75%, Missing); spinal cord: 74.5098% (minimum 75%, Missing); spleen: 54.2857% (minimum 65%, Missing); stomach: 64.4068% (minimum 70%, Missing); thymus: 43.1818% (minimum 65%, Missing); thyroid gland: 52.7778% (minimum 65%, Missing); tongue: 54.2857% (minimum 70%, Missing); urinary bladder: 62.2951% (minimum 70%, Missing)",-0.218182,-0.186486,-0.323034,0,5,partial,5.1,3.6,5,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215421,ZNF407,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.4068% (minimum 65%, Uncertain); adrenal gland: 67.8571% (minimum 75%, Missing); basal ganglia: 74.5098% (minimum 75%, Missing); bone marrow: 42.6966% (minimum 75%, Missing); cerebellum: 64.4068% (minimum 75%, Missing); cerebral cortex: 63.3333% (minimum 75%, Missing); colon: 58.4615% (minimum 70%, Missing); duodenum: 65.5172% (minimum 75%, Missing); esophagus: 62.2951% (minimum 70%, Missing); heart muscle: 55.8824% (minimum 75%, Missing); kidney: 63.3333% (minimum 75%, Missing); liver: 64.4068% (minimum 75%, Missing); lung: 63.3333% (minimum 75%, Missing); lymph node: 55.0725% (minimum 70%, Missing); pancreas: 65.5172% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 71.6981% (minimum 75%, Missing); rectum: 64.4068% (minimum 70%, Missing); retina: 58.4615% (minimum 75%, Missing); salivary gland: 63.3333% (minimum 70%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); skin: 63.3333% (minimum 65%, Missing); small intestine: 63.3333% (minimum 75%, Missing); smooth muscle: 56.7164% (minimum 75%, Missing); spinal cord: 74.5098% (minimum 75%, Missing); spleen: 54.2857% (minimum 65%, Missing); stomach: 64.4068% (minimum 70%, Missing); thymus: 43.1818% (minimum 65%, Missing); thyroid gland: 52.7778% (minimum 65%, Missing); tongue: 54.2857% (minimum 70%, Missing); urinary bladder: 62.2951% (minimum 70%, Missing)",-0.218182,-0.186486,-0.323034,0,5,partial,5.1,3.6,5,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215421,ZNF407,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.4068% (minimum 65%, Uncertain); adrenal gland: 67.8571% (minimum 75%, Missing); basal ganglia: 74.5098% (minimum 75%, Missing); bone marrow: 42.6966% (minimum 75%, Missing); cerebellum: 64.4068% (minimum 75%, Missing); cerebral cortex: 63.3333% (minimum 75%, Missing); colon: 58.4615% (minimum 70%, Missing); duodenum: 65.5172% (minimum 75%, Missing); esophagus: 62.2951% (minimum 70%, Missing); heart muscle: 55.8824% (minimum 75%, Missing); kidney: 63.3333% (minimum 75%, Missing); liver: 64.4068% (minimum 75%, Missing); lung: 63.3333% (minimum 75%, Missing); lymph node: 55.0725% (minimum 70%, Missing); pancreas: 65.5172% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 71.6981% (minimum 75%, Missing); rectum: 64.4068% (minimum 70%, Missing); retina: 58.4615% (minimum 75%, Missing); salivary gland: 63.3333% (minimum 70%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); skin: 63.3333% (minimum 65%, Missing); small intestine: 63.3333% (minimum 75%, Missing); smooth muscle: 56.7164% (minimum 75%, Missing); spinal cord: 74.5098% (minimum 75%, Missing); spleen: 54.2857% (minimum 65%, Missing); stomach: 64.4068% (minimum 70%, Missing); thymus: 43.1818% (minimum 65%, Missing); thyroid gland: 52.7778% (minimum 65%, Missing); tongue: 54.2857% (minimum 70%, Missing); urinary bladder: 62.2951% (minimum 70%, Missing)",-0.218182,-0.186486,-0.323034,0,5,partial,5.1,3.6,5,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215421,ZNF407,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.4068% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 67.8571% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.5098% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 42.6966% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.4068% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.3333% (minimum 75%, Baseline (adaptation disabled)); colon: 58.4615% (minimum 70%, Baseline (adaptation disabled)); duodenum: 65.5172% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.2951% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 55.8824% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.3333% (minimum 75%, Baseline (adaptation disabled)); liver: 64.4068% (minimum 75%, Baseline (adaptation disabled)); lung: 63.3333% (minimum 75%, Baseline (adaptation disabled)); lymph node: 55.0725% (minimum 70%, Baseline (adaptation disabled)); pancreas: 65.5172% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.3514% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.6981% (minimum 75%, Baseline (adaptation disabled)); rectum: 64.4068% (minimum 70%, Baseline (adaptation disabled)); retina: 58.4615% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.3333% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 50.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 63.3333% (minimum 65%, Baseline (adaptation disabled)); small intestine: 63.3333% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.7164% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 74.5098% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.2857% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.4068% (minimum 70%, Baseline (adaptation disabled)); thymus: 43.1818% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 52.7778% (minimum 65%, Baseline (adaptation disabled)); tongue: 54.2857% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.2951% (minimum 70%, Baseline (adaptation disabled))",-0.218182,-0.186486,-0.323034,0,5,partial,5.1,3.6,5,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215421,ZNF407,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,10.1,"skin: 10.1 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215455,KRTAP10-1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,10.1,"skin: 10.1 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215455,KRTAP10-1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,10.1,"skin: 10.1 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215455,KRTAP10-1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,10.1,"skin: 10.1 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215455,KRTAP10-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,10.1,"skin: 10.1 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215455,KRTAP10-1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 70.0000% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); retina: 77.7778% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing)",0.05,0.03,-0.29,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215474,SKOR2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 70.0000% (minimum 75%, Missing)",0.35,0.3,-0.05,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215474,SKOR2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 70.0000% (minimum 75%, Missing)",0.35,0.3,-0.05,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215474,SKOR2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 70.0000% (minimum 75%, Missing)",0.35,0.3,-0.05,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215474,SKOR2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 70.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.05,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215474,SKOR2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.0588% (minimum 99%, Missing); choroid plexus: 97.0588% (minimum 99%, Missing); liver: 97.0588% (minimum 99%, Missing); lung: 97.0588% (minimum 99%, Missing); pancreas: 97.0588% (minimum 99%, Missing); pituitary gland: 91.6667% (minimum 99%, Missing); small intestine: 91.6667% (minimum 99%, Missing); spleen: 91.6667% (minimum 95%, Missing); thyroid gland: 94.2857% (minimum 95%, Missing)",-0.0333333,0.000588235,-0.0733333,0,80,unavailable,0.3,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215529,EFCAB8,admission_only,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
True,compatible,,True,True,True,,0.266667,0.270588,0.166667,0,80,unavailable,0.3,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215529,EFCAB8,selectivity_revised,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
True,compatible,,True,True,True,,0.266667,0.270588,0.166667,0,80,unavailable,0.3,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215529,EFCAB8,grid_revised,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
True,compatible,,True,True,True,,0.266667,0.270588,0.166667,0,80,unavailable,0.3,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215529,EFCAB8,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
True,compatible,,True,True,True,,0.266667,0.270588,0.166667,0,80,unavailable,0.3,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215529,EFCAB8,current_fixed,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"spinal cord: 95.2381% (minimum 99%, Missing)",0.05,0.03,-0.037619,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215568,GAB4,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.202381,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215568,GAB4,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.202381,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215568,GAB4,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.202381,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215568,GAB4,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.202381,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215568,GAB4,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 96.0000% (minimum 99%, Missing); amygdala: 97.9592% (minimum 99%, Missing); basal ganglia: 97.9592% (minimum 99%, Missing); cerebellum: 96.0000% (minimum 99%, Missing); cerebral cortex: 97.9592% (minimum 99%, Missing); heart muscle: 94.1176% (minimum 99%, Missing); hippocampal formation: 97.9592% (minimum 99%, Missing); hypothalamus: 97.9592% (minimum 99%, Missing); kidney: 96.0000% (minimum 99%, Missing); liver: 96.0000% (minimum 99%, Missing); lung: 97.9592% (minimum 99%, Missing); midbrain: 97.9592% (minimum 99%, Missing); pancreas: 97.9592% (minimum 99%, Missing); pituitary gland: 96.0000% (minimum 99%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); skeletal muscle: 94.1176% (minimum 99%, Missing); small intestine: 96.0000% (minimum 99%, Missing); spinal cord: 97.9592% (minimum 99%, Missing)",0.01,-0.01,-0.0488235,0,80,unavailable,0.3,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215817,ZC3H11B,admission_only,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
True,compatible,,True,True,True,,0.31,0.26,0.191176,0,80,unavailable,0.3,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215817,ZC3H11B,selectivity_revised,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
True,compatible,,True,True,True,,0.31,0.26,0.191176,0,80,unavailable,0.3,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215817,ZC3H11B,grid_revised,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
True,compatible,,True,True,True,,0.31,0.26,0.191176,0,80,unavailable,0.3,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215817,ZC3H11B,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
True,compatible,,True,True,True,,0.31,0.26,0.191176,0,80,unavailable,0.3,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215817,ZC3H11B,current_fixed,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 90%, Approved); adrenal gland: 41.0959% (minimum 99%, Missing); amygdala: 61.2245% (minimum 99%, Missing); basal ganglia: 62.5000% (minimum 99%, Missing); bone marrow: 58.8235% (minimum 99%, Missing); cerebellum: 61.2245% (minimum 99%, Missing); cerebral cortex: 58.8235% (minimum 99%, Missing); choroid plexus: 58.8235% (minimum 99%, Missing); colon: 57.6923% (minimum 97%, Missing); duodenum: 55.5556% (minimum 99%, Missing); esophagus: 61.2245% (minimum 97%, Missing); heart muscle: 52.6316% (minimum 99%, Missing); hippocampal formation: 58.8235% (minimum 99%, Missing); hypothalamus: 65.2174% (minimum 99%, Missing); kidney: 55.5556% (minimum 99%, Missing); liver: 50.8475% (minimum 99%, Missing); lung: 63.8298% (minimum 99%, Missing); lymph node: 56.6038% (minimum 97%, Missing); midbrain: 60.0000% (minimum 99%, Missing); pancreas: 42.2535% (minimum 99%, Missing); parathyroid gland: 49.1803% (minimum 97%, Missing); pituitary gland: 45.4545% (minimum 99%, Missing); rectum: 56.6038% (minimum 97%, Missing); retina: 54.5455% (minimum 99%, Missing); salivary gland: 53.5714% (minimum 97%, Missing); skeletal muscle: 43.4783% (minimum 99%, Missing); skin: 48.3871% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 60.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 90%, Approved); stomach: 50.0000% (minimum 97%, Missing); thymus: 68.1818% (minimum 95%, Missing); thyroid gland: 55.5556% (minimum 95%, Missing); tongue: 52.6316% (minimum 97%, Missing); urinary bladder: 61.2245% (minimum 97%, Missing)",-0.466129,-0.478197,-0.579041,0,7,partial,4.3,3.1,3.2,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); stomach: 3 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215883,CYB5RL,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 41.0959% (minimum 75%, Missing); amygdala: 61.2245% (minimum 75%, Missing); basal ganglia: 62.5000% (minimum 75%, Missing); bone marrow: 58.8235% (minimum 75%, Missing); cerebellum: 61.2245% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); choroid plexus: 58.8235% (minimum 75%, Missing); colon: 57.6923% (minimum 70%, Missing); duodenum: 55.5556% (minimum 75%, Missing); esophagus: 61.2245% (minimum 70%, Missing); heart muscle: 52.6316% (minimum 75%, Missing); hippocampal formation: 58.8235% (minimum 75%, Missing); hypothalamus: 65.2174% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 50.8475% (minimum 75%, Missing); lung: 63.8298% (minimum 75%, Missing); lymph node: 56.6038% (minimum 70%, Missing); midbrain: 60.0000% (minimum 75%, Missing); pancreas: 42.2535% (minimum 75%, Missing); parathyroid gland: 49.1803% (minimum 70%, Missing); pituitary gland: 45.4545% (minimum 75%, Missing); rectum: 56.6038% (minimum 70%, Missing); retina: 54.5455% (minimum 75%, Missing); salivary gland: 53.5714% (minimum 70%, Missing); skeletal muscle: 43.4783% (minimum 75%, Missing); skin: 48.3871% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 60%, Approved); stomach: 50.0000% (minimum 70%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing); tongue: 52.6316% (minimum 70%, Missing); urinary bladder: 61.2245% (minimum 70%, Missing)",-0.166129,-0.208197,-0.339041,0,7,partial,4.3,3.1,3.2,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); stomach: 3 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215883,CYB5RL,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 41.0959% (minimum 75%, Missing); amygdala: 61.2245% (minimum 75%, Missing); basal ganglia: 62.5000% (minimum 75%, Missing); bone marrow: 58.8235% (minimum 75%, Missing); cerebellum: 61.2245% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); choroid plexus: 58.8235% (minimum 75%, Missing); colon: 57.6923% (minimum 70%, Missing); duodenum: 55.5556% (minimum 75%, Missing); esophagus: 61.2245% (minimum 70%, Missing); heart muscle: 52.6316% (minimum 75%, Missing); hippocampal formation: 58.8235% (minimum 75%, Missing); hypothalamus: 65.2174% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 50.8475% (minimum 75%, Missing); lung: 63.8298% (minimum 75%, Missing); lymph node: 56.6038% (minimum 70%, Missing); midbrain: 60.0000% (minimum 75%, Missing); pancreas: 42.2535% (minimum 75%, Missing); parathyroid gland: 49.1803% (minimum 70%, Missing); pituitary gland: 45.4545% (minimum 75%, Missing); rectum: 56.6038% (minimum 70%, Missing); retina: 54.5455% (minimum 75%, Missing); salivary gland: 53.5714% (minimum 70%, Missing); skeletal muscle: 43.4783% (minimum 75%, Missing); skin: 48.3871% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 60%, Approved); stomach: 50.0000% (minimum 70%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing); tongue: 52.6316% (minimum 70%, Missing); urinary bladder: 61.2245% (minimum 70%, Missing)",-0.166129,-0.208197,-0.339041,0,7,partial,4.3,3.1,3.2,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215883,CYB5RL,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 41.0959% (minimum 75%, Missing); amygdala: 61.2245% (minimum 75%, Missing); basal ganglia: 62.5000% (minimum 75%, Missing); bone marrow: 58.8235% (minimum 75%, Missing); cerebellum: 61.2245% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); choroid plexus: 58.8235% (minimum 75%, Missing); colon: 57.6923% (minimum 70%, Missing); duodenum: 55.5556% (minimum 75%, Missing); esophagus: 61.2245% (minimum 70%, Missing); heart muscle: 52.6316% (minimum 75%, Missing); hippocampal formation: 58.8235% (minimum 75%, Missing); hypothalamus: 65.2174% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 50.8475% (minimum 75%, Missing); lung: 63.8298% (minimum 75%, Missing); lymph node: 56.6038% (minimum 70%, Missing); midbrain: 60.0000% (minimum 75%, Missing); pancreas: 42.2535% (minimum 75%, Missing); parathyroid gland: 49.1803% (minimum 70%, Missing); pituitary gland: 45.4545% (minimum 75%, Missing); rectum: 56.6038% (minimum 70%, Missing); retina: 54.5455% (minimum 75%, Missing); salivary gland: 53.5714% (minimum 70%, Missing); skeletal muscle: 43.4783% (minimum 75%, Missing); skin: 48.3871% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 60%, Approved); stomach: 50.0000% (minimum 70%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing); tongue: 52.6316% (minimum 70%, Missing); urinary bladder: 61.2245% (minimum 70%, Missing)",-0.166129,-0.208197,-0.339041,0,7,partial,4.3,3.1,3.2,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215883,CYB5RL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 41.0959% (minimum 75%, Baseline (adaptation disabled)); amygdala: 61.2245% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.5000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 58.8235% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.2245% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.8235% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.8235% (minimum 75%, Baseline (adaptation disabled)); colon: 57.6923% (minimum 70%, Baseline (adaptation disabled)); duodenum: 55.5556% (minimum 75%, Baseline (adaptation disabled)); esophagus: 61.2245% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 52.6316% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.8235% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.2174% (minimum 75%, Baseline (adaptation disabled)); kidney: 55.5556% (minimum 75%, Baseline (adaptation disabled)); liver: 50.8475% (minimum 75%, Baseline (adaptation disabled)); lung: 63.8298% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.6038% (minimum 70%, Baseline (adaptation disabled)); midbrain: 60.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 42.2535% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.1803% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 45.4545% (minimum 75%, Baseline (adaptation disabled)); rectum: 56.6038% (minimum 70%, Baseline (adaptation disabled)); retina: 54.5455% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.5714% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 43.4783% (minimum 75%, Baseline (adaptation disabled)); skin: 48.3871% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 60.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 55.5556% (minimum 65%, Baseline (adaptation disabled)); tongue: 52.6316% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 61.2245% (minimum 70%, Baseline (adaptation disabled))",-0.166129,-0.208197,-0.339041,0,7,partial,4.3,3.1,3.2,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215883,CYB5RL,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 5.0000% (minimum 99%, Missing)",0.05,0.03,-0.94,0,80,unavailable,3.8,0,0,"retina: 3.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215906,LACTBL1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 5.0000% (minimum 75%, Missing)",0.35,0.3,-0.7,0,80,unavailable,3.8,0,0,"retina: 3.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215906,LACTBL1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 5.0000% (minimum 75%, Missing)",0.35,0.3,-0.7,0,80,unavailable,3.8,0,0,"retina: 3.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215906,LACTBL1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 5.0000% (minimum 75%, Missing)",0.35,0.3,-0.7,0,80,unavailable,3.8,0,0,"retina: 3.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215906,LACTBL1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 5.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.7,0,80,unavailable,3.8,0,0,"retina: 3.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000215906,LACTBL1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0463636,0.0263636,0.00636364,0,6,partial,0.5,0.1,0.3,,,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / hair follicles; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215910,C1orf167,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346364,0.296364,0.246364,0,6,partial,0.5,0.1,0.3,,,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / hair follicles; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215910,C1orf167,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346364,0.296364,0.246364,0,6,partial,0.5,0.1,0.3,,,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / hair follicles; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215910,C1orf167,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346364,0.296364,0.246364,0,6,partial,0.5,0.1,0.3,,,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / hair follicles; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215910,C1orf167,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.33917,0.296364,0.232079,0,6,partial,0.5,0.1,0.3,,,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / hair follicles; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000215910,C1orf167,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000216649,GAGE12E,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000216649,GAGE12E,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000216649,GAGE12E,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000216649,GAGE12E,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000216649,GAGE12E,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8432% (minimum 99%, Missing); bone marrow: 97.8372% (minimum 99%, Missing); duodenum: 98.8432% (minimum 99%, Missing); heart muscle: 98.7163% (minimum 99%, Missing); kidney: 98.8432% (minimum 99%, Missing); pancreas: 98.2120% (minimum 99%, Missing); pituitary gland: 98.5897% (minimum 99%, Missing); retina: 96.7296% (minimum 99%, Missing); small intestine: 98.9704% (minimum 99%, Missing); smooth muscle: 98.5897% (minimum 99%, Missing)",0.0296178,0.0108673,-0.0227044,0,80,unavailable,2.6,1.5,1.6,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000216937,CCDC7,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329618,0.280867,0.217296,0,80,unavailable,2.6,1.5,1.6,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000216937,CCDC7,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329618,0.280867,0.217296,0,80,unavailable,2.6,1.5,1.6,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000216937,CCDC7,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329618,0.280867,0.217296,0,80,unavailable,2.6,1.5,1.6,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000216937,CCDC7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329618,0.280867,0.217296,0,80,unavailable,2.6,1.5,1.6,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000216937,CCDC7,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.4319% (minimum 99%, Missing); basal ganglia: 98.2918% (minimum 99%, Missing); cerebral cortex: 98.6429% (minimum 99%, Missing); hippocampal formation: 98.8547% (minimum 99%, Missing); hypothalamus: 98.5724% (minimum 99%, Missing); kidney: 98.0824% (minimum 99%, Missing); liver: 98.7840% (minimum 99%, Missing); midbrain: 98.2219% (minimum 99%, Missing); spinal cord: 98.9964% (minimum 99%, Missing)",0.0378398,0.0256741,-0.00917614,0,80,unavailable,2.7,0.6,1.7,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000217442,SYCE3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33784,0.295674,0.230824,0,80,unavailable,2.7,0.6,1.7,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000217442,SYCE3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33784,0.295674,0.230824,0,80,unavailable,2.7,0.6,1.7,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000217442,SYCE3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33784,0.295674,0.230824,0,80,unavailable,2.7,0.6,1.7,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000217442,SYCE3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33784,0.295674,0.230824,0,80,unavailable,2.7,0.6,1.7,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000217442,SYCE3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 85.4839% (minimum 99%, Missing)",0.05,0.03,-0.135161,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000218819,TDRD15,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.104839,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000218819,TDRD15,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.104839,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000218819,TDRD15,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.104839,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000218819,TDRD15,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.104839,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000218819,TDRD15,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00315068,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000218823,PAPOLB,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.243151,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000218823,PAPOLB,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.243151,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000218823,PAPOLB,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.243151,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000218823,PAPOLB,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.243151,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000218823,PAPOLB,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.2258% (minimum 80%, Supported); adrenal gland: 85.3448% (minimum 97%, Supported); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 85.3448% (minimum 99%, Missing); bone marrow: 92.5234% (minimum 97%, Supported); cerebellum: 81.8182% (minimum 97%, Supported); cerebral cortex: 86.0870% (minimum 97%, Supported); colon: 84.6154% (minimum 90%, Supported); duodenum: 61.1111% (minimum 97%, Supported); esophagus: 79.8387% (minimum 90%, Supported); heart muscle: 55.0000% (minimum 97%, Supported); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 94.2857% (minimum 99%, Missing); kidney: 86.8421% (minimum 97%, Supported); liver: 66.8919% (minimum 97%, Supported); lung: 89.1892% (minimum 97%, Supported); midbrain: 90.8257% (minimum 99%, Missing); pancreas: 0.0206% (minimum 99%, Missing); pituitary gland: 81.8182% (minimum 99%, Missing); salivary gland: 51.0309% (minimum 90%, Supported); skeletal muscle: 86.8421% (minimum 97%, Supported); small intestine: 79.2000% (minimum 97%, Supported); spinal cord: 91.6667% (minimum 99%, Missing); stomach: 37.2180% (minimum 90%, Supported)",-0.267742,-0.52782,-0.989794,0,4,partial,48049.2,16.7,8.7,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 6); salivary gland: 9.5 nTPM (protected, limit 6); heart muscle: 8.1 nTPM (vital, limit 3); duodenum: 6.3 nTPM (vital, limit 3); liver: 4.9 nTPM (vital, limit 3); pituitary gland: 2.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000219073,CELA3B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.2258% (minimum 55%, Supported); duodenum: 61.1111% (minimum 65%, Supported); heart muscle: 55.0000% (minimum 65%, Supported); pancreas: 0.0206% (minimum 75%, Missing); salivary gland: 51.0309% (minimum 60%, Supported); stomach: 37.2180% (minimum 60%, Supported)",-0.0177419,-0.22782,-0.749794,0,4,partial,48049.2,16.7,8.7,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 6); salivary gland: 9.5 nTPM (protected, limit 6); heart muscle: 8.1 nTPM (vital, limit 3); duodenum: 6.3 nTPM (vital, limit 3); liver: 4.9 nTPM (vital, limit 3); pituitary gland: 2.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000219073,CELA3B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.2258% (minimum 55%, Supported); duodenum: 61.1111% (minimum 65%, Supported); heart muscle: 55.0000% (minimum 65%, Supported); pancreas: 0.0206% (minimum 75%, Missing); salivary gland: 51.0309% (minimum 60%, Supported); stomach: 37.2180% (minimum 60%, Supported)",-0.0177419,-0.22782,-0.749794,0,4,partial,48049.2,16.7,8.7,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 6); salivary gland: 9.5 nTPM (protected, limit 6); heart muscle: 8.1 nTPM (vital, limit 3); duodenum: 6.3 nTPM (vital, limit 3); liver: 4.9 nTPM (vital, limit 3); pituitary gland: 2.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000219073,CELA3B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.2258% (minimum 55%, Supported); duodenum: 61.1111% (minimum 65%, Supported); heart muscle: 55.0000% (minimum 65%, Supported); pancreas: 0.0206% (minimum 75%, Missing); salivary gland: 51.0309% (minimum 60%, Supported); stomach: 37.2180% (minimum 60%, Supported)",-0.0177419,-0.22782,-0.749794,0,4,partial,48049.2,16.7,8.7,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 6); salivary gland: 9.5 nTPM (protected, limit 6); heart muscle: 8.1 nTPM (vital, limit 3); duodenum: 6.3 nTPM (vital, limit 3); liver: 4.9 nTPM (vital, limit 3); pituitary gland: 2.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000219073,CELA3B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.2258% (minimum 65%, Baseline (adaptation disabled)); duodenum: 61.1111% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 55.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 66.8919% (minimum 75%, Baseline (adaptation disabled)); pancreas: 0.0206% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.0309% (minimum 70%, Baseline (adaptation disabled)); stomach: 37.2180% (minimum 70%, Baseline (adaptation disabled))",-0.117742,-0.32782,-0.749794,0,4,partial,48049.2,16.7,8.7,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 3); salivary gland: 9.5 nTPM (protected, limit 3); adipose tissue: 8.7 nTPM (manageable, limit 5); heart muscle: 8.1 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000219073,CELA3B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0478992,0.0291236,0.00424385,0,80,unavailable,3.3,0.5,1.2,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000219435,CATSPERZ,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347899,0.299124,0.244244,0,80,unavailable,3.3,0.5,1.2,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000219435,CATSPERZ,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347899,0.299124,0.244244,0,80,unavailable,3.3,0.5,1.2,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000219435,CATSPERZ,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347899,0.299124,0.244244,0,80,unavailable,3.3,0.5,1.2,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000219435,CATSPERZ,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347899,0.299124,0.244244,0,80,unavailable,3.3,0.5,1.2,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000219435,CATSPERZ,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 65.8838% (minimum 95%, Missing); adrenal gland: 57.4254% (minimum 99%, Missing); amygdala: 33.6656% (minimum 99%, Missing); basal ganglia: 35.8303% (minimum 99%, Missing); bone marrow: 49.3147% (minimum 99%, Missing); cerebellum: 30.4676% (minimum 99%, Missing); cerebral cortex: 26.0097% (minimum 99%, Missing); choroid plexus: 68.8150% (minimum 99%, Missing); colon: 64.1971% (minimum 97%, Missing); duodenum: 79.7975% (minimum 99%, Missing); esophagus: 73.6866% (minimum 97%, Missing); heart muscle: 63.0957% (minimum 99%, Missing); hippocampal formation: 33.6861% (minimum 99%, Missing); hypothalamus: 36.6556% (minimum 99%, Missing); kidney: 56.5812% (minimum 99%, Missing); liver: 73.9500% (minimum 99%, Missing); lung: 66.6801% (minimum 99%, Missing); lymph node: 70.6963% (minimum 97%, Missing); midbrain: 39.2087% (minimum 99%, Missing); pancreas: 67.9114% (minimum 99%, Missing); parathyroid gland: 48.5765% (minimum 97%, Missing); pituitary gland: 42.7759% (minimum 99%, Missing); rectum: 76.9052% (minimum 97%, Missing); retina: 27.4598% (minimum 99%, Missing); salivary gland: 70.2760% (minimum 97%, Missing); skeletal muscle: 63.4829% (minimum 99%, Missing); skin: 58.9808% (minimum 95%, Missing); small intestine: 65.0295% (minimum 99%, Missing); smooth muscle: 71.7693% (minimum 99%, Missing); spinal cord: 49.2413% (minimum 99%, Missing); spleen: 59.4896% (minimum 95%, Missing); stomach: 65.9100% (minimum 97%, Missing); thymus: 70.3956% (minimum 95%, Missing); thyroid gland: 62.5709% (minimum 95%, Missing); tongue: 73.0362% (minimum 97%, Missing); urinary bladder: 68.4167% (minimum 97%, Missing)",-0.360192,-0.484235,-0.729903,0,80,unavailable,470.8,175.2,115.1,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 2); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); skin: 115.1 nTPM (manageable, limit 5); spleen: 112.7 nTPM (manageable, limit 5); thyroid gland: 99 nTPM (manageable, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 2); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (manageable, limit 5); stomach: 85.6 nTPM (protected, limit 2); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 2); choroid plexus: 75 nTPM (vital, limit 1); salivary gland: 70 nTPM (protected, limit 2); thymus: 69.6 nTPM (manageable, limit 5); lymph node: 68.6 nTPM (protected, limit 2); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 2); esophagus: 59.1 nTPM (protected, limit 2); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 2); duodenum: 41.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000220205,VAMP2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.4254% (minimum 75%, Missing); amygdala: 33.6656% (minimum 75%, Missing); basal ganglia: 35.8303% (minimum 75%, Missing); bone marrow: 49.3147% (minimum 75%, Missing); cerebellum: 30.4676% (minimum 75%, Missing); cerebral cortex: 26.0097% (minimum 75%, Missing); choroid plexus: 68.8150% (minimum 75%, Missing); colon: 64.1971% (minimum 70%, Missing); heart muscle: 63.0957% (minimum 75%, Missing); hippocampal formation: 33.6861% (minimum 75%, Missing); hypothalamus: 36.6556% (minimum 75%, Missing); kidney: 56.5812% (minimum 75%, Missing); liver: 73.9500% (minimum 75%, Missing); lung: 66.6801% (minimum 75%, Missing); midbrain: 39.2087% (minimum 75%, Missing); pancreas: 67.9114% (minimum 75%, Missing); parathyroid gland: 48.5765% (minimum 70%, Missing); pituitary gland: 42.7759% (minimum 75%, Missing); retina: 27.4598% (minimum 75%, Missing); skeletal muscle: 63.4829% (minimum 75%, Missing); skin: 58.9808% (minimum 65%, Missing); small intestine: 65.0295% (minimum 75%, Missing); smooth muscle: 71.7693% (minimum 75%, Missing); spinal cord: 49.2413% (minimum 75%, Missing); spleen: 59.4896% (minimum 65%, Missing); stomach: 65.9100% (minimum 70%, Missing); thyroid gland: 62.5709% (minimum 65%, Missing); urinary bladder: 68.4167% (minimum 70%, Missing)",-0.0601924,-0.214235,-0.489903,0,80,unavailable,470.8,175.2,115.1,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 2); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); skin: 115.1 nTPM (manageable, limit 5); spleen: 112.7 nTPM (manageable, limit 5); thyroid gland: 99 nTPM (manageable, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 2); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (manageable, limit 5); stomach: 85.6 nTPM (protected, limit 2); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 2); choroid plexus: 75 nTPM (vital, limit 1); salivary gland: 70 nTPM (protected, limit 2); thymus: 69.6 nTPM (manageable, limit 5); lymph node: 68.6 nTPM (protected, limit 2); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 2); esophagus: 59.1 nTPM (protected, limit 2); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 2); duodenum: 41.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000220205,VAMP2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.4254% (minimum 75%, Missing); amygdala: 33.6656% (minimum 75%, Missing); basal ganglia: 35.8303% (minimum 75%, Missing); bone marrow: 49.3147% (minimum 75%, Missing); cerebellum: 30.4676% (minimum 75%, Missing); cerebral cortex: 26.0097% (minimum 75%, Missing); choroid plexus: 68.8150% (minimum 75%, Missing); colon: 64.1971% (minimum 70%, Missing); heart muscle: 63.0957% (minimum 75%, Missing); hippocampal formation: 33.6861% (minimum 75%, Missing); hypothalamus: 36.6556% (minimum 75%, Missing); kidney: 56.5812% (minimum 75%, Missing); liver: 73.9500% (minimum 75%, Missing); lung: 66.6801% (minimum 75%, Missing); midbrain: 39.2087% (minimum 75%, Missing); pancreas: 67.9114% (minimum 75%, Missing); parathyroid gland: 48.5765% (minimum 70%, Missing); pituitary gland: 42.7759% (minimum 75%, Missing); retina: 27.4598% (minimum 75%, Missing); skeletal muscle: 63.4829% (minimum 75%, Missing); skin: 58.9808% (minimum 65%, Missing); small intestine: 65.0295% (minimum 75%, Missing); smooth muscle: 71.7693% (minimum 75%, Missing); spinal cord: 49.2413% (minimum 75%, Missing); spleen: 59.4896% (minimum 65%, Missing); stomach: 65.9100% (minimum 70%, Missing); thyroid gland: 62.5709% (minimum 65%, Missing); urinary bladder: 68.4167% (minimum 70%, Missing)",-0.0601924,-0.214235,-0.489903,0,80,unavailable,470.8,175.2,115.1,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 3); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); skin: 115.1 nTPM (manageable, limit 5); spleen: 112.7 nTPM (manageable, limit 5); thyroid gland: 99 nTPM (manageable, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 3); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (manageable, limit 5); stomach: 85.6 nTPM (protected, limit 3); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 3); choroid plexus: 75 nTPM (vital, limit 1); salivary gland: 70 nTPM (protected, limit 3); thymus: 69.6 nTPM (manageable, limit 5); lymph node: 68.6 nTPM (protected, limit 3); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 3); esophagus: 59.1 nTPM (protected, limit 3); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 3); duodenum: 41.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000220205,VAMP2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.4254% (minimum 75%, Missing); amygdala: 33.6656% (minimum 75%, Missing); basal ganglia: 35.8303% (minimum 75%, Missing); bone marrow: 49.3147% (minimum 75%, Missing); cerebellum: 30.4676% (minimum 75%, Missing); cerebral cortex: 26.0097% (minimum 75%, Missing); choroid plexus: 68.8150% (minimum 75%, Missing); colon: 64.1971% (minimum 70%, Missing); heart muscle: 63.0957% (minimum 75%, Missing); hippocampal formation: 33.6861% (minimum 75%, Missing); hypothalamus: 36.6556% (minimum 75%, Missing); kidney: 56.5812% (minimum 75%, Missing); liver: 73.9500% (minimum 75%, Missing); lung: 66.6801% (minimum 75%, Missing); midbrain: 39.2087% (minimum 75%, Missing); pancreas: 67.9114% (minimum 75%, Missing); parathyroid gland: 48.5765% (minimum 70%, Missing); pituitary gland: 42.7759% (minimum 75%, Missing); retina: 27.4598% (minimum 75%, Missing); skeletal muscle: 63.4829% (minimum 75%, Missing); skin: 58.9808% (minimum 65%, Missing); small intestine: 65.0295% (minimum 75%, Missing); smooth muscle: 71.7693% (minimum 75%, Missing); spinal cord: 49.2413% (minimum 75%, Missing); spleen: 59.4896% (minimum 65%, Missing); stomach: 65.9100% (minimum 70%, Missing); thyroid gland: 62.5709% (minimum 65%, Missing); urinary bladder: 68.4167% (minimum 70%, Missing)",-0.0601924,-0.214235,-0.489903,0,80,unavailable,470.8,175.2,115.1,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 3); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); skin: 115.1 nTPM (manageable, limit 5); spleen: 112.7 nTPM (manageable, limit 5); thyroid gland: 99 nTPM (manageable, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 3); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (manageable, limit 5); stomach: 85.6 nTPM (protected, limit 3); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 3); choroid plexus: 75 nTPM (vital, limit 1); salivary gland: 70 nTPM (protected, limit 3); thymus: 69.6 nTPM (manageable, limit 5); lymph node: 68.6 nTPM (protected, limit 3); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 3); esophagus: 59.1 nTPM (protected, limit 3); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 3); duodenum: 41.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000220205,VAMP2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.4254% (minimum 75%, Baseline (adaptation disabled)); amygdala: 33.6656% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 35.8303% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 49.3147% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 30.4676% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 26.0097% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.8150% (minimum 75%, Baseline (adaptation disabled)); colon: 64.1971% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 63.0957% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 33.6861% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 36.6556% (minimum 75%, Baseline (adaptation disabled)); kidney: 56.5812% (minimum 75%, Baseline (adaptation disabled)); liver: 73.9500% (minimum 75%, Baseline (adaptation disabled)); lung: 66.6801% (minimum 75%, Baseline (adaptation disabled)); midbrain: 39.2087% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.9114% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 48.5765% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 42.7759% (minimum 75%, Baseline (adaptation disabled)); retina: 27.4598% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 63.4829% (minimum 75%, Baseline (adaptation disabled)); skin: 58.9808% (minimum 65%, Baseline (adaptation disabled)); small intestine: 65.0295% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.7693% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 49.2413% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.4896% (minimum 65%, Baseline (adaptation disabled)); stomach: 65.9100% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 62.5709% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 68.4167% (minimum 70%, Baseline (adaptation disabled))",-0.0601924,-0.214235,-0.489903,0,80,unavailable,470.8,175.2,115.1,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 3); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); skin: 115.1 nTPM (manageable, limit 5); spleen: 112.7 nTPM (manageable, limit 5); thyroid gland: 99 nTPM (manageable, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 3); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (manageable, limit 5); stomach: 85.6 nTPM (protected, limit 3); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 3); choroid plexus: 75 nTPM (vital, limit 1); salivary gland: 70 nTPM (protected, limit 3); thymus: 69.6 nTPM (manageable, limit 5); lymph node: 68.6 nTPM (protected, limit 3); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 3); esophagus: 59.1 nTPM (protected, limit 3); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 3); duodenum: 41.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000220205,VAMP2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 99%, Missing); pancreas: 28.5714% (minimum 99%, Missing)",0.05,0.03,-0.704286,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221813,OR6B1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); pancreas: 28.5714% (minimum 75%, Missing)",0.35,0.3,-0.464286,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221813,OR6B1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); pancreas: 28.5714% (minimum 75%, Missing)",0.35,0.3,-0.464286,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221813,OR6B1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); pancreas: 28.5714% (minimum 75%, Missing)",0.35,0.3,-0.464286,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221813,OR6B1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 28.5714% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.464286,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221813,OR6B1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0.6,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221826,PSG3,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.6,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221826,PSG3,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.6,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221826,PSG3,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.6,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221826,PSG3,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.347821,0.299273,0.245652,0,2,partial,0.6,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221826,PSG3,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2143% (minimum 99%, Missing); amygdala: 98.2143% (minimum 99%, Missing); basal ganglia: 98.2143% (minimum 99%, Missing); cerebellum: 96.4912% (minimum 99%, Missing); cerebral cortex: 94.8276% (minimum 99%, Missing); duodenum: 98.2143% (minimum 99%, Missing); heart muscle: 98.2143% (minimum 99%, Missing); hippocampal formation: 98.2143% (minimum 99%, Missing); hypothalamus: 98.2143% (minimum 99%, Missing); kidney: 98.2143% (minimum 99%, Missing); liver: 94.8276% (minimum 99%, Missing); midbrain: 98.2143% (minimum 99%, Missing); pancreas: 98.2143% (minimum 99%, Missing); pituitary gland: 93.2203% (minimum 99%, Missing); retina: 78.5714% (minimum 99%, Missing); small intestine: 98.2143% (minimum 99%, Missing); spinal cord: 98.2143% (minimum 99%, Missing); stomach: 96.4912% (minimum 97%, Missing)",0.0149123,-0.00508772,-0.204286,0,80,unavailable,1.5,0.2,0.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221843,SPATA31H1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.314912,0.264912,0.0357143,0,80,unavailable,1.5,0.2,0.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221843,SPATA31H1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.314912,0.264912,0.0357143,0,80,unavailable,1.5,0.2,0.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221843,SPATA31H1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.314912,0.264912,0.0357143,0,80,unavailable,1.5,0.2,0.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221843,SPATA31H1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.314912,0.264912,0.0357143,0,80,unavailable,1.5,0.2,0.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221843,SPATA31H1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221855,TAS2R41,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221855,TAS2R41,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221855,TAS2R41,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221855,TAS2R41,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221855,TAS2R41,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.025,0.03,0.01,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221867,MAGEA3,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.325,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221867,MAGEA3,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.325,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221867,MAGEA3,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.325,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221867,MAGEA3,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.325,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221867,MAGEA3,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 76.9231% (minimum 80%, Supported); smooth muscle: 88.8889% (minimum 97%, Supported)",-0.0307692,0.03,-0.0811111,0,2,partial,0.5,0,1.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221878,PSG7,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.219231,0.3,0.238889,0,2,partial,0.5,0,1.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221878,PSG7,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.219231,0.3,0.238889,0,2,partial,0.5,0,1.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221878,PSG7,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.219231,0.3,0.238889,0,2,partial,0.5,0,1.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221878,PSG7,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.119231,0.3,0.138889,0,2,partial,0.5,0,1.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221878,PSG7,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna,True,True,True,"cerebral cortex: 87.5000% (minimum 99%, Missing); choroid plexus: 96.5517% (minimum 99%, Missing); lung: 96.5517% (minimum 99%, Missing); lymph node: 90.3226% (minimum 97%, Missing); retina: 75.6757% (minimum 99%, Missing); skeletal muscle: 90.3226% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Missing); thymus: 90.3226% (minimum 95%, Missing)",-0.0467742,-0.0667742,-0.233243,9,80,unavailable,0.9,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221882,OR3A2,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,unresolved,incomplete_routine_rna,True,True,True,,0.253226,0.203226,0.00675676,9,80,unavailable,0.9,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221882,OR3A2,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,unresolved,incomplete_routine_rna,True,True,True,,0.253226,0.203226,0.00675676,9,80,unavailable,0.9,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221882,OR3A2,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,unresolved,incomplete_routine_rna,True,True,True,,0.253226,0.203226,0.00675676,9,80,unavailable,0.9,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221882,OR3A2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,unresolved,incomplete_routine_rna,True,True,True,,0.253226,0.203226,0.00675676,9,80,unavailable,0.9,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221882,OR3A2,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.1538% (minimum 99%, Missing); retina: 92.5926% (minimum 99%, Missing)",0.05,0.03,-0.0640741,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221888,OR1C1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.175926,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221888,OR1C1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.175926,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221888,OR1C1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.175926,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221888,OR1C1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.175926,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221888,OR1C1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221900,POM121L12,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221900,POM121L12,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221900,POM121L12,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221900,POM121L12,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221900,POM121L12,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221910,OR2F2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221910,OR2F2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221910,OR2F2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221910,OR2F2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221910,OR2F2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 79.3706% (minimum 95%, Uncertain); adrenal gland: 68.3049% (minimum 99%, Uncertain); amygdala: 89.7233% (minimum 99%, Missing); basal ganglia: 88.0983% (minimum 99%, Missing); bone marrow: 79.2782% (minimum 99%, Missing); cerebellum: 93.0328% (minimum 99%, Uncertain); cerebral cortex: 89.6053% (minimum 99%, Uncertain); choroid plexus: 90.5585% (minimum 99%, Missing); colon: 83.3537% (minimum 97%, Uncertain); duodenum: 75.1656% (minimum 99%, Uncertain); esophagus: 32.4440% (minimum 97%, Missing); heart muscle: 75.3319% (minimum 99%, Uncertain); hippocampal formation: 90.3183% (minimum 99%, Missing); hypothalamus: 86.3118% (minimum 99%, Missing); kidney: 89.1361% (minimum 99%, Missing); liver: 92.1516% (minimum 99%, Uncertain); lung: 82.8467% (minimum 99%, Uncertain); lymph node: 87.4198% (minimum 97%, Missing); midbrain: 84.8070% (minimum 99%, Missing); pancreas: 92.0270% (minimum 99%, Uncertain); parathyroid gland: 94.7149% (minimum 97%, Missing); pituitary gland: 94.0608% (minimum 99%, Missing); rectum: 85.5528% (minimum 97%, Uncertain); retina: 93.8017% (minimum 99%, Missing); salivary gland: 64.8571% (minimum 97%, Missing); skeletal muscle: 65.7336% (minimum 99%, Uncertain); skin: 61.0215% (minimum 95%, Missing); small intestine: 84.5963% (minimum 99%, Uncertain); smooth muscle: 87.6448% (minimum 99%, Uncertain); spinal cord: 82.1472% (minimum 99%, Missing); spleen: 92.0270% (minimum 95%, Uncertain); stomach: 68.0320% (minimum 97%, Missing); thymus: 87.0844% (minimum 95%, Missing); thyroid gland: 78.9108% (minimum 95%, Missing); tongue: 69.3483% (minimum 97%, Missing); urinary bladder: 66.1808% (minimum 97%, Missing)",-0.339785,-0.64556,-0.332664,0,3,partial,35.5,141.8,43.5,"esophagus: 141.8 nTPM (protected, limit 2); skin: 43.5 nTPM (manageable, limit 5); salivary gland: 36.9 nTPM (protected, limit 2); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 2); stomach: 32 nTPM (protected, limit 2); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 2); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (manageable, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 2); hypothalamus: 10.8 nTPM (vital, limit 1); thymus: 10.1 nTPM (manageable, limit 5); lymph node: 9.8 nTPM (protected, limit 2); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221926,TRIM16,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.3049% (minimum 75%, Uncertain); esophagus: 32.4440% (minimum 70%, Missing); salivary gland: 64.8571% (minimum 70%, Missing); skeletal muscle: 65.7336% (minimum 75%, Uncertain); skin: 61.0215% (minimum 65%, Missing); stomach: 68.0320% (minimum 70%, Missing); tongue: 69.3483% (minimum 70%, Missing); urinary bladder: 66.1808% (minimum 70%, Missing)",-0.0397849,-0.37556,-0.0926641,0,3,partial,35.5,141.8,43.5,"esophagus: 141.8 nTPM (protected, limit 2); skin: 43.5 nTPM (manageable, limit 5); salivary gland: 36.9 nTPM (protected, limit 2); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 2); stomach: 32 nTPM (protected, limit 2); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 2); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (manageable, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 2); hypothalamus: 10.8 nTPM (vital, limit 1); thymus: 10.1 nTPM (manageable, limit 5); lymph node: 9.8 nTPM (protected, limit 2); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221926,TRIM16,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.3049% (minimum 75%, Uncertain); esophagus: 32.4440% (minimum 70%, Missing); salivary gland: 64.8571% (minimum 70%, Missing); skeletal muscle: 65.7336% (minimum 75%, Uncertain); skin: 61.0215% (minimum 65%, Missing); stomach: 68.0320% (minimum 70%, Missing); tongue: 69.3483% (minimum 70%, Missing); urinary bladder: 66.1808% (minimum 70%, Missing)",-0.0397849,-0.37556,-0.0926641,0,3,partial,35.5,141.8,43.5,"esophagus: 141.8 nTPM (protected, limit 3); skin: 43.5 nTPM (manageable, limit 5); salivary gland: 36.9 nTPM (protected, limit 3); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 3); stomach: 32 nTPM (protected, limit 3); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 3); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (manageable, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 3); hypothalamus: 10.8 nTPM (vital, limit 1); thymus: 10.1 nTPM (manageable, limit 5); lymph node: 9.8 nTPM (protected, limit 3); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221926,TRIM16,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.3049% (minimum 75%, Uncertain); esophagus: 32.4440% (minimum 70%, Missing); salivary gland: 64.8571% (minimum 70%, Missing); skeletal muscle: 65.7336% (minimum 75%, Uncertain); skin: 61.0215% (minimum 65%, Missing); stomach: 68.0320% (minimum 70%, Missing); tongue: 69.3483% (minimum 70%, Missing); urinary bladder: 66.1808% (minimum 70%, Missing)",-0.0397849,-0.37556,-0.0926641,0,3,partial,35.5,141.8,43.5,"esophagus: 141.8 nTPM (protected, limit 3); skin: 43.5 nTPM (manageable, limit 5); salivary gland: 36.9 nTPM (protected, limit 3); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 3); stomach: 32 nTPM (protected, limit 3); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 3); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (manageable, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 3); hypothalamus: 10.8 nTPM (vital, limit 1); thymus: 10.1 nTPM (manageable, limit 5); lymph node: 9.8 nTPM (protected, limit 3); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221926,TRIM16,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.3049% (minimum 75%, Baseline (adaptation disabled)); esophagus: 32.4440% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 64.8571% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 65.7336% (minimum 75%, Baseline (adaptation disabled)); skin: 61.0215% (minimum 65%, Baseline (adaptation disabled)); stomach: 68.0320% (minimum 70%, Baseline (adaptation disabled)); tongue: 69.3483% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 66.1808% (minimum 70%, Baseline (adaptation disabled))",-0.0397849,-0.37556,-0.0926641,0,3,partial,35.5,141.8,43.5,"esophagus: 141.8 nTPM (protected, limit 3); skin: 43.5 nTPM (manageable, limit 5); salivary gland: 36.9 nTPM (protected, limit 3); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 3); stomach: 32 nTPM (protected, limit 3); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 3); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (manageable, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 3); hypothalamus: 10.8 nTPM (vital, limit 1); thymus: 10.1 nTPM (manageable, limit 5); lymph node: 9.8 nTPM (protected, limit 3); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221926,TRIM16,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 86.5854% (minimum 99%, Missing); amygdala: 95.9459% (minimum 99%, Missing); basal ganglia: 97.2603% (minimum 99%, Missing); bone marrow: 97.2603% (minimum 99%, Missing); cerebral cortex: 94.6667% (minimum 99%, Missing); choroid plexus: 98.6111% (minimum 99%, Missing); colon: 89.8734% (minimum 97%, Missing); duodenum: 73.1959% (minimum 99%, Missing); esophagus: 93.4211% (minimum 97%, Missing); heart muscle: 97.2603% (minimum 99%, Missing); hippocampal formation: 97.2603% (minimum 99%, Missing); hypothalamus: 95.9459% (minimum 99%, Missing); kidney: 94.6667% (minimum 99%, Missing); liver: 68.9320% (minimum 95%, Enhanced); lung: 92.2078% (minimum 99%, Missing); midbrain: 95.9459% (minimum 99%, Missing); pancreas: 95.9459% (minimum 99%, Missing); pituitary gland: 92.2078% (minimum 99%, Missing); retina: 78.0220% (minimum 99%, Missing); salivary gland: 93.4211% (minimum 97%, Missing); skeletal muscle: 98.6111% (minimum 99%, Missing); skin: 88.7500% (minimum 95%, Missing); small intestine: 57.7236% (minimum 99%, Missing); spinal cord: 95.9459% (minimum 99%, Missing); stomach: 81.6092% (minimum 97%, Missing); thymus: 94.6667% (minimum 95%, Missing); thyroid gland: 94.6667% (minimum 95%, Missing); tongue: 95.9459% (minimum 97%, Missing); urinary bladder: 88.7500% (minimum 97%, Missing)",-0.0625,-0.153908,-0.412764,0,2,partial,5.2,1.6,0.9,"small intestine: 5.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221947,XKR9,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 73.1959% (minimum 75%, Missing); small intestine: 57.7236% (minimum 75%, Missing)",0.2375,0.116092,-0.172764,0,2,partial,5.2,1.6,0.9,"small intestine: 5.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221947,XKR9,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 73.1959% (minimum 75%, Missing); small intestine: 57.7236% (minimum 75%, Missing)",0.2375,0.116092,-0.172764,0,2,partial,5.2,1.6,0.9,"small intestine: 5.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221947,XKR9,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 73.1959% (minimum 75%, Missing); small intestine: 57.7236% (minimum 75%, Missing)",0.2375,0.116092,-0.172764,0,2,partial,5.2,1.6,0.9,"small intestine: 5.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221947,XKR9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 73.1959% (minimum 75%, Baseline (adaptation disabled)); liver: 68.9320% (minimum 75%, Baseline (adaptation disabled)); small intestine: 57.7236% (minimum 75%, Baseline (adaptation disabled))",0.2375,0.116092,-0.172764,0,2,partial,5.2,1.6,0.9,"small intestine: 5.2 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000221947,XKR9,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221977,OR4E2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221977,OR4E2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221977,OR4E2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221977,OR4E2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000221977,OR4E2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 0.9967% (minimum 95%, Missing)",-0.940033,0.03,0.01,0,4,partial,0,0,29.8,"thymus: 29.8 nTPM (manageable, limit 5)",thymus / cortical cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; thymus / cortical cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000222028,PSMB11,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 0.9967% (minimum 65%, Missing)",-0.640033,0.3,0.25,0,4,partial,0,0,29.8,"thymus: 29.8 nTPM (manageable, limit 5)",thymus / cortical cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; thymus / cortical cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000222028,PSMB11,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 0.9967% (minimum 65%, Missing)",-0.640033,0.3,0.25,0,4,partial,0,0,29.8,"thymus: 29.8 nTPM (manageable, limit 5)",thymus / cortical cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; thymus / cortical cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000222028,PSMB11,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 0.9967% (minimum 65%, Missing)",-0.640033,0.3,0.25,0,4,partial,0,0,29.8,"thymus: 29.8 nTPM (manageable, limit 5)",thymus / cortical cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; thymus / cortical cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000222028,PSMB11,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 0.9967% (minimum 65%, Baseline (adaptation disabled))",-0.640033,0.3,0.25,0,4,partial,0,0,29.8,"thymus: 29.8 nTPM (manageable, limit 5)",thymus / cortical cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; thymus / cortical cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000222028,PSMB11,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.9071% (minimum 99%, Missing); bone marrow: 98.9071% (minimum 99%, Missing); duodenum: 98.9071% (minimum 99%, Missing); heart muscle: 98.3696% (minimum 99%, Missing); lung: 98.9071% (minimum 99%, Missing); pancreas: 98.9071% (minimum 99%, Missing); retina: 95.7672% (minimum 99%, Missing)",0.0179144,0.0136957,-0.032328,0,80,unavailable,0.8,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000222036,POTEM,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.317914,0.283696,0.207672,0,80,unavailable,0.8,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000222036,POTEM,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.317914,0.283696,0.207672,0,80,unavailable,0.8,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000222036,POTEM,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.317914,0.283696,0.207672,0,80,unavailable,0.8,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000222036,POTEM,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.317914,0.283696,0.207672,0,80,unavailable,0.8,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000222036,POTEM,current_fixed,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5437% (minimum 99%, Missing); bone marrow: 97.1292% (minimum 99%, Missing); duodenum: 96.6667% (minimum 99%, Missing); liver: 98.0676% (minimum 99%, Missing); lung: 98.5437% (minimum 99%, Missing); lymph node: 88.6463% (minimum 97%, Missing); retina: 98.0676% (minimum 99%, Missing); salivary gland: 96.6667% (minimum 97%, Missing); skin: 86.3830% (minimum 95%, Missing); small intestine: 96.2085% (minimum 99%, Missing)",-0.0861702,-0.0835371,-0.0279147,0,80,unavailable,0.8,2.6,3.2,"lymph node: 2.6 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223510,CDRT15,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.21383,0.186463,0.212085,0,80,unavailable,0.8,2.6,3.2,"lymph node: 2.6 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223510,CDRT15,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.21383,0.186463,0.212085,0,80,unavailable,0.8,2.6,3.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223510,CDRT15,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.21383,0.186463,0.212085,0,80,unavailable,0.8,2.6,3.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223510,CDRT15,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.21383,0.186463,0.212085,0,80,unavailable,0.8,2.6,3.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223510,CDRT15,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 55.0000% (minimum 99%, Missing); basal ganglia: 22.0000% (minimum 99%, Missing); cerebral cortex: 64.7059% (minimum 99%, Missing); hippocampal formation: 68.7500% (minimum 99%, Missing); hypothalamus: 22.0000% (minimum 99%, Missing); midbrain: 64.7059% (minimum 99%, Missing); pituitary gland: 84.6154% (minimum 99%, Missing); spinal cord: 78.5714% (minimum 99%, Missing)",0.05,0.03,-0.77,0,80,unavailable,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223591,CENPVL1,admission_only,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 55.0000% (minimum 75%, Missing); basal ganglia: 22.0000% (minimum 75%, Missing); cerebral cortex: 64.7059% (minimum 75%, Missing); hippocampal formation: 68.7500% (minimum 75%, Missing); hypothalamus: 22.0000% (minimum 75%, Missing); midbrain: 64.7059% (minimum 75%, Missing)",0.35,0.3,-0.53,0,80,unavailable,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223591,CENPVL1,selectivity_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 55.0000% (minimum 75%, Missing); basal ganglia: 22.0000% (minimum 75%, Missing); cerebral cortex: 64.7059% (minimum 75%, Missing); hippocampal formation: 68.7500% (minimum 75%, Missing); hypothalamus: 22.0000% (minimum 75%, Missing); midbrain: 64.7059% (minimum 75%, Missing)",0.35,0.3,-0.53,0,80,unavailable,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223591,CENPVL1,grid_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 55.0000% (minimum 75%, Missing); basal ganglia: 22.0000% (minimum 75%, Missing); cerebral cortex: 64.7059% (minimum 75%, Missing); hippocampal formation: 68.7500% (minimum 75%, Missing); hypothalamus: 22.0000% (minimum 75%, Missing); midbrain: 64.7059% (minimum 75%, Missing)",0.35,0.3,-0.53,0,80,unavailable,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223591,CENPVL1,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 55.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 22.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.7059% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.7500% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 22.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 64.7059% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.53,0,80,unavailable,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223591,CENPVL1,current_fixed,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 96.4286% (minimum 99%, Missing); lymph node: 96.4286% (minimum 97%, Missing); pituitary gland: 96.4286% (minimum 99%, Missing); retina: 96.4286% (minimum 99%, Missing); skeletal muscle: 96.4286% (minimum 99%, Missing)",0.05,-0.00571429,-0.0257143,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223601,EBLN1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.264286,0.214286,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223601,EBLN1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.264286,0.214286,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223601,EBLN1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.264286,0.214286,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223601,EBLN1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.264286,0.214286,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223601,EBLN1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000223614,ZNF735,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000223614,ZNF735,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000223614,ZNF735,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000223614,ZNF735,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000223614,ZNF735,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.4762% (minimum 95%, Enhanced); amygdala: 17.4099% (minimum 99%, Missing); basal ganglia: 14.6079% (minimum 99%, Missing); cerebellum: 33.0243% (minimum 95%, Enhanced); cerebral cortex: 16.9240% (minimum 99%, Missing); choroid plexus: 66.4336% (minimum 99%, Missing); colon: 89.3417% (minimum 97%, Missing); heart muscle: 87.1560% (minimum 99%, Missing); hippocampal formation: 16.7549% (minimum 99%, Missing); hypothalamus: 21.1581% (minimum 99%, Missing); midbrain: 15.2081% (minimum 99%, Missing); pituitary gland: 69.6822% (minimum 99%, Missing); retina: 86.1027% (minimum 99%, Missing); skeletal muscle: 61.9565% (minimum 95%, Enhanced); small intestine: 96.9388% (minimum 99%, Missing); spinal cord: 14.9764% (minimum 99%, Missing); tongue: 71.6080% (minimum 97%, Missing)",0.0395833,-0.25392,-0.843921,0,10,partial,166.6,11.3,1,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 6); skeletal muscle: 17.5 nTPM (vital, limit 6); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 2); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223802,CERS1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 17.4099% (minimum 75%, Missing); basal ganglia: 14.6079% (minimum 75%, Missing); cerebellum: 33.0243% (minimum 60%, Enhanced); cerebral cortex: 16.9240% (minimum 75%, Missing); choroid plexus: 66.4336% (minimum 75%, Missing); hippocampal formation: 16.7549% (minimum 75%, Missing); hypothalamus: 21.1581% (minimum 75%, Missing); midbrain: 15.2081% (minimum 75%, Missing); pituitary gland: 69.6822% (minimum 75%, Missing); spinal cord: 14.9764% (minimum 75%, Missing)",0.339583,0.0160804,-0.603921,0,10,partial,166.6,11.3,1,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 6); skeletal muscle: 17.5 nTPM (vital, limit 6); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 2); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223802,CERS1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 17.4099% (minimum 75%, Missing); basal ganglia: 14.6079% (minimum 75%, Missing); cerebellum: 33.0243% (minimum 60%, Enhanced); cerebral cortex: 16.9240% (minimum 75%, Missing); choroid plexus: 66.4336% (minimum 75%, Missing); hippocampal formation: 16.7549% (minimum 75%, Missing); hypothalamus: 21.1581% (minimum 75%, Missing); midbrain: 15.2081% (minimum 75%, Missing); pituitary gland: 69.6822% (minimum 75%, Missing); spinal cord: 14.9764% (minimum 75%, Missing)",0.339583,0.0160804,-0.603921,0,10,partial,166.6,11.3,1,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 6); skeletal muscle: 17.5 nTPM (vital, limit 6); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 3); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223802,CERS1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 17.4099% (minimum 75%, Missing); basal ganglia: 14.6079% (minimum 75%, Missing); cerebellum: 33.0243% (minimum 60%, Enhanced); cerebral cortex: 16.9240% (minimum 75%, Missing); choroid plexus: 66.4336% (minimum 75%, Missing); hippocampal formation: 16.7549% (minimum 75%, Missing); hypothalamus: 21.1581% (minimum 75%, Missing); midbrain: 15.2081% (minimum 75%, Missing); pituitary gland: 69.6822% (minimum 75%, Missing); spinal cord: 14.9764% (minimum 75%, Missing)",0.339583,0.0160804,-0.603921,0,10,partial,166.6,11.3,1,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 6); skeletal muscle: 17.5 nTPM (vital, limit 6); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 3); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223802,CERS1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 17.4099% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 14.6079% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 33.0243% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 16.9240% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.4336% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 16.7549% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 21.1581% (minimum 75%, Baseline (adaptation disabled)); midbrain: 15.2081% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 69.6822% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 61.9565% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 14.9764% (minimum 75%, Baseline (adaptation disabled))",0.316102,0.0160804,-0.603921,0,10,partial,166.6,11.3,1,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 1); skeletal muscle: 17.5 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 3); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); adrenal gland: 3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000223802,CERS1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224089,CT47A10,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224089,CT47A10,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224089,CT47A10,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224089,CT47A10,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224089,CT47A10,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 98.2456% (minimum 99%, Missing); bone marrow: 97.3913% (minimum 99%, Missing); cerebral cortex: 98.2456% (minimum 99%, Missing)",0.05,0.03,-0.016087,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000224107,ETDB,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.223913,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000224107,ETDB,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.223913,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000224107,ETDB,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.223913,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000224107,ETDB,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.223913,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000224107,ETDB,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000224440,CXorf51A,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000224440,CXorf51A,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000224440,CXorf51A,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000224440,CXorf51A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000224440,CXorf51A,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224586,GPX5,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224586,GPX5,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224586,GPX5,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224586,GPX5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224586,GPX5,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 91.0931% (minimum 99%, Missing)",0.05,0.03,-0.0790688,0,4,partial,2.2,0.2,0,"retina: 2.2 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224659,GAGE12J,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.160931,0,4,partial,2.2,0.2,0,"retina: 2.2 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224659,GAGE12J,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.160931,0,4,partial,2.2,0.2,0,"retina: 2.2 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224659,GAGE12J,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.160931,0,4,partial,2.2,0.2,0,"retina: 2.2 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224659,GAGE12J,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.291189,0.160931,0,4,partial,2.2,0.2,0,"retina: 2.2 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224659,GAGE12J,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224902,GAGE12H,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224902,GAGE12H,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224902,GAGE12H,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224902,GAGE12H,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224902,GAGE12H,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224960,PPP4R3C,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224960,PPP4R3C,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224960,PPP4R3C,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224960,PPP4R3C,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000224960,PPP4R3C,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.9677% (minimum 95%, Missing); adrenal gland: 81.4815% (minimum 99%, Missing); amygdala: 62.8571% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 95.6522% (minimum 99%, Missing); cerebellum: 91.6667% (minimum 99%, Missing); cerebral cortex: 62.8571% (minimum 99%, Missing); colon: 88.0000% (minimum 97%, Missing); duodenum: 91.6667% (minimum 99%, Missing); esophagus: 95.6522% (minimum 97%, Missing); heart muscle: 84.6154% (minimum 99%, Missing); hippocampal formation: 61.1111% (minimum 99%, Missing); hypothalamus: 70.9677% (minimum 99%, Missing); kidney: 95.6522% (minimum 99%, Missing); liver: 95.6522% (minimum 99%, Missing); lung: 88.0000% (minimum 99%, Missing); lymph node: 78.5714% (minimum 97%, Missing); midbrain: 70.9677% (minimum 99%, Missing); pancreas: 88.0000% (minimum 99%, Missing); parathyroid gland: 95.6522% (minimum 97%, Missing); pituitary gland: 95.6522% (minimum 99%, Missing); salivary gland: 84.6154% (minimum 97%, Missing); skeletal muscle: 78.5714% (minimum 99%, Missing); skin: 88.0000% (minimum 95%, Missing); small intestine: 84.6154% (minimum 99%, Missing); smooth muscle: 73.3333% (minimum 99%, Missing); spinal cord: 70.9677% (minimum 99%, Missing); spleen: 73.3333% (minimum 95%, Missing); stomach: 84.6154% (minimum 97%, Missing); thymus: 84.6154% (minimum 95%, Missing); tongue: 95.6522% (minimum 97%, Missing); urinary bladder: 70.9677% (minimum 97%, Missing)",-0.240323,-0.260323,-0.378889,0,80,unavailable,1.4,0.9,0.9,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225614,ZNF469,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 62.8571% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 62.8571% (minimum 75%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 70.9677% (minimum 75%, Missing); midbrain: 70.9677% (minimum 75%, Missing); smooth muscle: 73.3333% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing)",0.0596774,0.00967742,-0.138889,0,80,unavailable,1.4,0.9,0.9,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225614,ZNF469,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 62.8571% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 62.8571% (minimum 75%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 70.9677% (minimum 75%, Missing); midbrain: 70.9677% (minimum 75%, Missing); smooth muscle: 73.3333% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing)",0.0596774,0.00967742,-0.138889,0,80,unavailable,1.4,0.9,0.9,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225614,ZNF469,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 62.8571% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 62.8571% (minimum 75%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 70.9677% (minimum 75%, Missing); midbrain: 70.9677% (minimum 75%, Missing); smooth muscle: 73.3333% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing)",0.0596774,0.00967742,-0.138889,0,80,unavailable,1.4,0.9,0.9,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225614,ZNF469,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 62.8571% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.8571% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 61.1111% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 70.9677% (minimum 75%, Baseline (adaptation disabled)); midbrain: 70.9677% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.9677% (minimum 75%, Baseline (adaptation disabled))",0.0596774,0.00967742,-0.138889,0,80,unavailable,1.4,0.9,0.9,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225614,ZNF469,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225781,OR6V1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225781,OR6V1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225781,OR6V1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225781,OR6V1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225781,OR6V1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.7111% (minimum 99%, Missing); amygdala: 94.0226% (minimum 99%, Missing); basal ganglia: 94.9429% (minimum 99%, Missing); bone marrow: 98.2278% (minimum 99%, Missing); cerebellum: 93.5691% (minimum 99%, Missing); cerebral cortex: 95.4098% (minimum 99%, Missing); colon: 96.9192% (minimum 97%, Missing); heart muscle: 97.3244% (minimum 99%, Missing); hippocampal formation: 95.3317% (minimum 99%, Missing); hypothalamus: 95.4881% (minimum 99%, Missing); kidney: 93.1946% (minimum 99%, Missing); liver: 92.3077% (minimum 99%, Missing); lung: 96.5174% (minimum 99%, Missing); midbrain: 95.0204% (minimum 99%, Missing); pancreas: 97.1619% (minimum 99%, Missing); pituitary gland: 96.7581% (minimum 99%, Missing); salivary gland: 96.7581% (minimum 97%, Missing); skeletal muscle: 98.5605% (minimum 99%, Missing); small intestine: 95.5665% (minimum 99%, Missing); spinal cord: 95.9604% (minimum 99%, Missing); spleen: 93.1946% (minimum 95%, Missing); stomach: 96.6777% (minimum 97%, Missing); thyroid gland: 94.8655% (minimum 95%, Missing); urinary bladder: 96.2779% (minimum 97%, Missing)",-0.0180544,-0.00722084,-0.0669231,0,80,unavailable,9.7,4.5,8.5,"liver: 9.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); spinal cord: 4.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); pituitary gland: 3.9 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225828,FAM229A,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.281946,0.262779,0.173077,0,80,unavailable,9.7,4.5,8.5,"liver: 9.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); spinal cord: 4.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); pituitary gland: 3.9 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225828,FAM229A,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.281946,0.262779,0.173077,0,80,unavailable,9.7,4.5,8.5,"liver: 9.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); spinal cord: 4.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); pituitary gland: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225828,FAM229A,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.281946,0.262779,0.173077,0,80,unavailable,9.7,4.5,8.5,"liver: 9.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); spinal cord: 4.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); pituitary gland: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225828,FAM229A,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.281946,0.262779,0.173077,0,80,unavailable,9.7,4.5,8.5,"liver: 9.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); spinal cord: 4.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); pituitary gland: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000225828,FAM229A,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226023,CT47A6,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226023,CT47A6,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226023,CT47A6,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226023,CT47A6,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226023,CT47A6,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226372,DCAF8L1,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226372,DCAF8L1,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226372,DCAF8L1,grid_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226372,DCAF8L1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226372,DCAF8L1,current_fixed,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226600,CT47A9,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226600,CT47A9,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226600,CT47A9,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226600,CT47A9,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226600,CT47A9,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226650,KIF4B,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226650,KIF4B,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226650,KIF4B,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226650,KIF4B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226650,KIF4B,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226685,CT47A12,admission_only,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226685,CT47A12,selectivity_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226685,CT47A12,grid_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226685,CT47A12,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226685,CT47A12,current_fixed,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226929,CT47A11,admission_only,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226929,CT47A11,selectivity_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226929,CT47A11,grid_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226929,CT47A11,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226929,CT47A11,current_fixed,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226941,RBMY1J,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226941,RBMY1J,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226941,RBMY1J,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226941,RBMY1J,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000226941,RBMY1J,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227059,ANHX,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227059,ANHX,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227059,ANHX,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227059,ANHX,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227059,ANHX,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.3769% (minimum 95%, Missing); adrenal gland: 72.8155% (minimum 99%, Missing); amygdala: 77.3196% (minimum 99%, Missing); basal ganglia: 74.6269% (minimum 99%, Missing); bone marrow: 84.7458% (minimum 99%, Missing); cerebellum: 78.5340% (minimum 99%, Missing); cerebral cortex: 77.7202% (minimum 99%, Missing); choroid plexus: 78.9474% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 73.1707% (minimum 99%, Missing); esophagus: 74.2574% (minimum 97%, Missing); heart muscle: 72.4638% (minimum 99%, Missing); hippocampal formation: 75.7576% (minimum 99%, Missing); hypothalamus: 74.2574% (minimum 99%, Missing); kidney: 60.9756% (minimum 99%, Missing); liver: 66.0793% (minimum 99%, Missing); lung: 76.9231% (minimum 99%, Missing); lymph node: 76.1421% (minimum 97%, Missing); midbrain: 73.8916% (minimum 99%, Missing); pancreas: 63.2911% (minimum 99%, Missing); parathyroid gland: 64.9351% (minimum 97%, Missing); pituitary gland: 62.5000% (minimum 99%, Missing); rectum: 69.7674% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 68.1818% (minimum 97%, Missing); skeletal muscle: 78.5340% (minimum 99%, Missing); skin: 60.7287% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 78.5340% (minimum 99%, Missing); spinal cord: 70.7547% (minimum 99%, Missing); spleen: 68.4932% (minimum 95%, Missing); stomach: 67.5676% (minimum 97%, Missing); thymus: 76.1421% (minimum 95%, Missing); thyroid gland: 61.9835% (minimum 95%, Missing); tongue: 78.1250% (minimum 97%, Missing); urinary bladder: 72.8155% (minimum 97%, Missing)",-0.342713,-0.320649,-0.380244,0,80,unavailable,9.6,8.1,9.7,"skin: 9.7 nTPM (manageable, limit 5); kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 2); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); salivary gland: 7 nTPM (protected, limit 2); spleen: 6.9 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 2); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 2); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227124,ZNF717,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.8155% (minimum 75%, Missing); basal ganglia: 74.6269% (minimum 75%, Missing); duodenum: 73.1707% (minimum 75%, Missing); heart muscle: 72.4638% (minimum 75%, Missing); hypothalamus: 74.2574% (minimum 75%, Missing); kidney: 60.9756% (minimum 75%, Missing); liver: 66.0793% (minimum 75%, Missing); midbrain: 73.8916% (minimum 75%, Missing); pancreas: 63.2911% (minimum 75%, Missing); parathyroid gland: 64.9351% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 69.7674% (minimum 70%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skin: 60.7287% (minimum 65%, Missing); spinal cord: 70.7547% (minimum 75%, Missing); stomach: 67.5676% (minimum 70%, Missing); thyroid gland: 61.9835% (minimum 65%, Missing)",-0.0427126,-0.0506494,-0.140244,0,80,unavailable,9.6,8.1,9.7,"skin: 9.7 nTPM (manageable, limit 5); kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 2); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); salivary gland: 7 nTPM (protected, limit 2); spleen: 6.9 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 2); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 2); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227124,ZNF717,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.8155% (minimum 75%, Missing); basal ganglia: 74.6269% (minimum 75%, Missing); duodenum: 73.1707% (minimum 75%, Missing); heart muscle: 72.4638% (minimum 75%, Missing); hypothalamus: 74.2574% (minimum 75%, Missing); kidney: 60.9756% (minimum 75%, Missing); liver: 66.0793% (minimum 75%, Missing); midbrain: 73.8916% (minimum 75%, Missing); pancreas: 63.2911% (minimum 75%, Missing); parathyroid gland: 64.9351% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 69.7674% (minimum 70%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skin: 60.7287% (minimum 65%, Missing); spinal cord: 70.7547% (minimum 75%, Missing); stomach: 67.5676% (minimum 70%, Missing); thyroid gland: 61.9835% (minimum 65%, Missing)",-0.0427126,-0.0506494,-0.140244,0,80,unavailable,9.6,8.1,9.7,"skin: 9.7 nTPM (manageable, limit 5); kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 3); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); salivary gland: 7 nTPM (protected, limit 3); spleen: 6.9 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 3); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 3); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); hippocampal formation: 4.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 3); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227124,ZNF717,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.8155% (minimum 75%, Missing); basal ganglia: 74.6269% (minimum 75%, Missing); duodenum: 73.1707% (minimum 75%, Missing); heart muscle: 72.4638% (minimum 75%, Missing); hypothalamus: 74.2574% (minimum 75%, Missing); kidney: 60.9756% (minimum 75%, Missing); liver: 66.0793% (minimum 75%, Missing); midbrain: 73.8916% (minimum 75%, Missing); pancreas: 63.2911% (minimum 75%, Missing); parathyroid gland: 64.9351% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 69.7674% (minimum 70%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skin: 60.7287% (minimum 65%, Missing); spinal cord: 70.7547% (minimum 75%, Missing); stomach: 67.5676% (minimum 70%, Missing); thyroid gland: 61.9835% (minimum 65%, Missing)",-0.0427126,-0.0506494,-0.140244,0,80,unavailable,9.6,8.1,9.7,"skin: 9.7 nTPM (manageable, limit 5); kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 3); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); salivary gland: 7 nTPM (protected, limit 3); spleen: 6.9 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 3); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 3); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); hippocampal formation: 4.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 3); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227124,ZNF717,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.8155% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 74.6269% (minimum 75%, Baseline (adaptation disabled)); duodenum: 73.1707% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 72.4638% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 74.2574% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.9756% (minimum 75%, Baseline (adaptation disabled)); liver: 66.0793% (minimum 75%, Baseline (adaptation disabled)); midbrain: 73.8916% (minimum 75%, Baseline (adaptation disabled)); pancreas: 63.2911% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 64.9351% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.5000% (minimum 75%, Baseline (adaptation disabled)); rectum: 69.7674% (minimum 70%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.1818% (minimum 70%, Baseline (adaptation disabled)); skin: 60.7287% (minimum 65%, Baseline (adaptation disabled)); spinal cord: 70.7547% (minimum 75%, Baseline (adaptation disabled)); stomach: 67.5676% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 61.9835% (minimum 65%, Baseline (adaptation disabled))",-0.0427126,-0.0506494,-0.140244,0,80,unavailable,9.6,8.1,9.7,"skin: 9.7 nTPM (manageable, limit 5); kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 3); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); salivary gland: 7 nTPM (protected, limit 3); spleen: 6.9 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 3); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 3); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); hippocampal formation: 4.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 3); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227124,ZNF717,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000227151,PRR20D,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000227151,PRR20D,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000227151,PRR20D,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000227151,PRR20D,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000227151,PRR20D,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.0185452,0.01,0,3,partial,0.3,1,0.6,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227234,SPANXB1,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.288545,0.25,0,3,partial,0.3,1,0.6,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227234,SPANXB1,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.288545,0.25,0,3,partial,0.3,1,0.6,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227234,SPANXB1,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.288545,0.25,0,3,partial,0.3,1,0.6,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227234,SPANXB1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.343096,0.288545,0.246536,0,3,partial,0.3,1,0.6,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227234,SPANXB1,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227488,GAGE12D,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227488,GAGE12D,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227488,GAGE12D,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227488,GAGE12D,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227488,GAGE12D,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.042629,0.0263009,0.00262899,0,80,unavailable,0.6,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227868,TEX46,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342629,0.296301,0.242629,0,80,unavailable,0.6,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227868,TEX46,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342629,0.296301,0.242629,0,80,unavailable,0.6,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227868,TEX46,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342629,0.296301,0.242629,0,80,unavailable,0.6,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227868,TEX46,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342629,0.296301,0.242629,0,80,unavailable,0.6,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000227868,TEX46,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00962798,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228075,BOD1L2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249628,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228075,BOD1L2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249628,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228075,BOD1L2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249628,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228075,BOD1L2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.249628,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228075,BOD1L2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000228372,SMIM10L2B-AS1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000228372,SMIM10L2B-AS1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000228372,SMIM10L2B-AS1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000228372,SMIM10L2B-AS1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000228372,SMIM10L2B-AS1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228517,CT47A7,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228517,CT47A7,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228517,CT47A7,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228517,CT47A7,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228517,CT47A7,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000228567,VN1R4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000228567,VN1R4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000228567,VN1R4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000228567,VN1R4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000228567,VN1R4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 86.2069% (minimum 99%, Missing); basal ganglia: 51.0204% (minimum 99%, Missing); bone marrow: 92.5926% (minimum 97%, Supported); cerebral cortex: 94.3396% (minimum 97%, Supported); hippocampal formation: 92.5926% (minimum 99%, Missing); hypothalamus: 75.7576% (minimum 99%, Missing); midbrain: 92.5926% (minimum 99%, Missing); pancreas: 87.7193% (minimum 97%, Supported); pituitary gland: 72.4638% (minimum 99%, Missing); retina: 83.3333% (minimum 99%, Missing); spinal cord: 90.9091% (minimum 99%, Missing)",0.05,0.03,-0.479796,0,1,partial,4.8,0.1,0.1,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000228836,CT45A5,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 51.0204% (minimum 75%, Missing); pituitary gland: 72.4638% (minimum 75%, Missing)",0.35,0.3,-0.239796,0,1,partial,4.8,0.1,0.1,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000228836,CT45A5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 51.0204% (minimum 75%, Missing); pituitary gland: 72.4638% (minimum 75%, Missing)",0.35,0.3,-0.239796,0,1,partial,4.8,0.1,0.1,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000228836,CT45A5,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 51.0204% (minimum 75%, Missing); pituitary gland: 72.4638% (minimum 75%, Missing)",0.35,0.3,-0.239796,0,1,partial,4.8,0.1,0.1,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000228836,CT45A5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 51.0204% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 72.4638% (minimum 75%, Baseline (adaptation disabled))",0.330392,0.280392,-0.239796,0,1,partial,4.8,0.1,0.1,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000228836,CT45A5,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228927,TSPY3,admission_only,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228927,TSPY3,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228927,TSPY3,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228927,TSPY3,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.235484,0.25,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000228927,TSPY3,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 66.6667% (minimum 99%, Missing); liver: 25.0000% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); spleen: 40.0000% (minimum 95%, Missing)",-0.55,0.03,-0.74,0,80,unavailable,0.6,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000229292,RFPL4AL1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 66.6667% (minimum 75%, Missing); liver: 25.0000% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing)",-0.25,0.3,-0.5,0,80,unavailable,0.6,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000229292,RFPL4AL1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 66.6667% (minimum 75%, Missing); liver: 25.0000% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing)",-0.25,0.3,-0.5,0,80,unavailable,0.6,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000229292,RFPL4AL1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 66.6667% (minimum 75%, Missing); liver: 25.0000% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing)",-0.25,0.3,-0.5,0,80,unavailable,0.6,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000229292,RFPL4AL1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 66.6667% (minimum 75%, Baseline (adaptation disabled)); liver: 25.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 40.0000% (minimum 65%, Baseline (adaptation disabled))",-0.25,0.3,-0.5,0,80,unavailable,0.6,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000229292,RFPL4AL1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229549,TSPY8,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229549,TSPY8,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229549,TSPY8,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229549,TSPY8,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229549,TSPY8,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000229665,PRR20C,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000229665,PRR20C,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000229665,PRR20C,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000229665,PRR20C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000229665,PRR20C,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.3636% (minimum 95%, Missing); bone marrow: 43.1818% (minimum 99%, Missing); cerebral cortex: 90.4762% (minimum 99%, Missing); colon: 90.4762% (minimum 97%, Missing); esophagus: 90.4762% (minimum 97%, Missing); heart muscle: 95.0000% (minimum 99%, Missing); kidney: 90.4762% (minimum 99%, Missing); lung: 95.0000% (minimum 99%, Missing); lymph node: 86.3636% (minimum 97%, Missing); pancreas: 90.4762% (minimum 99%, Missing); parathyroid gland: 86.3636% (minimum 97%, Missing); rectum: 86.3636% (minimum 97%, Missing); retina: 90.4762% (minimum 99%, Missing); salivary gland: 95.0000% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); skin: 82.6087% (minimum 95%, Missing); small intestine: 95.0000% (minimum 99%, Missing); smooth muscle: 90.4762% (minimum 99%, Missing); spleen: 90.4762% (minimum 95%, Missing); stomach: 95.0000% (minimum 97%, Missing); thymus: 73.0769% (minimum 95%, Missing); thyroid gland: 86.3636% (minimum 95%, Missing); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 95.0000% (minimum 97%, Missing)",-0.219231,-0.106364,-0.558182,0,80,unavailable,2.5,0.3,0.7,"bone marrow: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229676,ZNF492,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 43.1818% (minimum 75%, Missing)",0.0807692,0.163636,-0.318182,0,80,unavailable,2.5,0.3,0.7,"bone marrow: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229676,ZNF492,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 43.1818% (minimum 75%, Missing)",0.0807692,0.163636,-0.318182,0,80,unavailable,2.5,0.3,0.7,"bone marrow: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229676,ZNF492,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 43.1818% (minimum 75%, Missing)",0.0807692,0.163636,-0.318182,0,80,unavailable,2.5,0.3,0.7,"bone marrow: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229676,ZNF492,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 43.1818% (minimum 75%, Baseline (adaptation disabled))",0.0807692,0.163636,-0.318182,0,80,unavailable,2.5,0.3,0.7,"bone marrow: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229676,ZNF492,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.9466% (minimum 99%, Missing)",0.0421875,0.03,-0.0205344,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229894,GK3,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;Jamin 2021
True,compatible,,True,True,True,,0.342187,0.3,0.219466,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229894,GK3,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;Jamin 2021
True,compatible,,True,True,True,,0.342187,0.3,0.219466,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229894,GK3,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;Jamin 2021
True,compatible,,True,True,True,,0.342187,0.3,0.219466,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229894,GK3,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;Jamin 2021
True,compatible,,True,True,True,,0.342187,0.3,0.219466,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229894,GK3,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229937,PRPS1L1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229937,PRPS1L1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229937,PRPS1L1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229937,PRPS1L1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229937,PRPS1L1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00612403,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229972,IQCF3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246124,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229972,IQCF3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246124,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229972,IQCF3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246124,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229972,IQCF3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.246124,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000229972,IQCF3,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230031,POTEB2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230031,POTEB2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230031,POTEB2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230031,POTEB2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230031,POTEB2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.044003,0.028494,0.0054955,0,80,unavailable,0.3,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230054,TEX53,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.344003,0.298494,0.245495,0,80,unavailable,0.3,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230054,TEX53,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.344003,0.298494,0.245495,0,80,unavailable,0.3,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230054,TEX53,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.344003,0.298494,0.245495,0,80,unavailable,0.3,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230054,TEX53,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.344003,0.298494,0.245495,0,80,unavailable,0.3,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230054,TEX53,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230178,OR4F3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230178,OR4F3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230178,OR4F3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230178,OR4F3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230178,OR4F3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna,True,True,True,"bone marrow: 92.2078% (minimum 99%, Missing); cerebral cortex: 98.6111% (minimum 99%, Missing)",0.05,0.03,-0.0679221,9,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230246,SPATA31C1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.172078,9,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230246,SPATA31C1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.172078,9,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230246,SPATA31C1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.172078,9,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230246,SPATA31C1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.172078,9,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230246,SPATA31C1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230268,SSU72L6,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230268,SSU72L6,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230268,SSU72L6,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230268,SSU72L6,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230268,SSU72L6,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230301,OR5H6,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230301,OR5H6,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230301,OR5H6,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230301,OR5H6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230301,OR5H6,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230347,CT47A8,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230347,CT47A8,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230347,CT47A8,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230347,CT47A8,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230347,CT47A8,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230522,MBD3L2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230522,MBD3L2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230522,MBD3L2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230522,MBD3L2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000230522,MBD3L2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230594,CT47A4,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230594,CT47A4,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230594,CT47A4,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230594,CT47A4,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230594,CT47A4,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00227799,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230601,TEX48,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242278,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230601,TEX48,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242278,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230601,TEX48,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242278,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230601,TEX48,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.242278,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000230601,TEX48,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.9925% (minimum 98%, Approved); pancreas: 97.7273% (minimum 98%, Approved); retina: 97.7273% (minimum 99%, Missing); skeletal muscle: 96.2687% (minimum 98%, Approved)",0.05,0.03,-0.0173134,0,3,partial,0.5,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231256,CFAP97D1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.227273,0,3,partial,0.5,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231256,CFAP97D1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.227273,0,3,partial,0.5,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231256,CFAP97D1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.227273,0,3,partial,0.5,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231256,CFAP97D1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.327273,0.292308,0.212687,0,3,partial,0.5,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231256,CFAP97D1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.6190% (minimum 99%, Missing); amygdala: 98.6254% (minimum 99%, Missing); basal ganglia: 98.6254% (minimum 99%, Missing); cerebellum: 98.1197% (minimum 99%, Missing); cerebral cortex: 98.6254% (minimum 99%, Missing); esophagus: 84.2878% (minimum 97%, Missing); heart muscle: 98.2877% (minimum 99%, Missing); hippocampal formation: 97.9522% (minimum 99%, Missing); hypothalamus: 97.6190% (minimum 99%, Missing); kidney: 97.9522% (minimum 99%, Missing); liver: 96.9595% (minimum 99%, Missing); lung: 98.1197% (minimum 99%, Missing); midbrain: 97.6190% (minimum 99%, Missing); pancreas: 98.6254% (minimum 99%, Missing); pituitary gland: 93.7908% (minimum 99%, Missing); salivary gland: 20.0000% (minimum 97%, Missing); small intestine: 98.6254% (minimum 99%, Missing); spinal cord: 96.6330% (minimum 99%, Missing)",0.0278535,-0.77,-0.0520915,0,80,unavailable,3.8,229.6,1.3,"salivary gland: 229.6 nTPM (protected, limit 2); esophagus: 10.7 nTPM (protected, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231887,PRH1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 20.0000% (minimum 70%, Missing)",0.327853,-0.5,0.187908,0,80,unavailable,3.8,229.6,1.3,"salivary gland: 229.6 nTPM (protected, limit 2); esophagus: 10.7 nTPM (protected, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231887,PRH1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 20.0000% (minimum 70%, Missing)",0.327853,-0.5,0.187908,0,80,unavailable,3.8,229.6,1.3,"salivary gland: 229.6 nTPM (protected, limit 3); esophagus: 10.7 nTPM (protected, limit 3); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231887,PRH1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 20.0000% (minimum 70%, Missing)",0.327853,-0.5,0.187908,0,80,unavailable,3.8,229.6,1.3,"salivary gland: 229.6 nTPM (protected, limit 3); esophagus: 10.7 nTPM (protected, limit 3); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231887,PRH1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 20.0000% (minimum 70%, Baseline (adaptation disabled))",0.327853,-0.5,0.187908,0,80,unavailable,3.8,229.6,1.3,"salivary gland: 229.6 nTPM (protected, limit 3); esophagus: 10.7 nTPM (protected, limit 3); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231887,PRH1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.00960427,0,2,partial,0.5,0.4,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231924,PSG1,admission_only,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.249604,0,2,partial,0.5,0.4,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231924,PSG1,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.249604,0,2,partial,0.5,0.4,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231924,PSG1,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.249604,0,2,partial,0.5,0.4,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231924,PSG1,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.34763,0.298419,0.248024,0,2,partial,0.5,0.4,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231924,PSG1,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.05,0.03,0.0053271,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231989,PPP1R2B,admission_only,True,False,True,True,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.245327,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231989,PPP1R2B,selectivity_revised,True,False,True,True,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.245327,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231989,PPP1R2B,grid_revised,True,False,True,True,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.245327,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231989,PPP1R2B,current_adaptive,True,False,True,True,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.245327,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000231989,PPP1R2B,current_fixed,True,False,True,True,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232030,MAGEB6B,admission_only,True,False,True,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232030,MAGEB6B,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232030,MAGEB6B,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232030,MAGEB6B,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232030,MAGEB6B,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.4444% (minimum 99%, Missing); amygdala: 96.5909% (minimum 99%, Missing); basal ganglia: 93.4066% (minimum 99%, Missing); bone marrow: 98.8372% (minimum 99%, Missing); cerebellum: 81.7308% (minimum 99%, Missing); cerebral cortex: 92.3913% (minimum 99%, Missing); choroid plexus: 97.7011% (minimum 99%, Missing); colon: 95.5056% (minimum 97%, Missing); duodenum: 97.7011% (minimum 99%, Missing); heart muscle: 97.7011% (minimum 99%, Missing); hippocampal formation: 96.5909% (minimum 99%, Missing); hypothalamus: 92.3913% (minimum 99%, Missing); kidney: 91.3978% (minimum 99%, Missing); liver: 88.5417% (minimum 99%, Missing); lung: 95.5056% (minimum 99%, Missing); midbrain: 97.7011% (minimum 99%, Missing); pancreas: 91.3978% (minimum 99%, Missing); parathyroid gland: 90.4255% (minimum 97%, Missing); pituitary gland: 93.4066% (minimum 99%, Missing); rectum: 94.4444% (minimum 97%, Missing); retina: 85.0000% (minimum 99%, Missing); salivary gland: 92.3913% (minimum 97%, Missing); small intestine: 97.7011% (minimum 99%, Missing); smooth muscle: 96.5909% (minimum 99%, Missing); spinal cord: 98.8372% (minimum 99%, Missing); stomach: 96.5909% (minimum 97%, Missing); thyroid gland: 84.1584% (minimum 95%, Missing)",-0.108416,-0.0657447,-0.172692,0,80,unavailable,1.9,0.9,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232040,SCAND3,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191584,0.204255,0.0673077,0,80,unavailable,1.9,0.9,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232040,SCAND3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191584,0.204255,0.0673077,0,80,unavailable,1.9,0.9,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232040,SCAND3,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191584,0.204255,0.0673077,0,80,unavailable,1.9,0.9,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232040,SCAND3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191584,0.204255,0.0673077,0,80,unavailable,1.9,0.9,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232040,SCAND3,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000232113,TEX50,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000232113,TEX50,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000232113,TEX50,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000232113,TEX50,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000232113,TEX50,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232423,PRAMEF6,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232423,PRAMEF6,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232423,PRAMEF6,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232423,PRAMEF6,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000232423,PRAMEF6,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000232948,DEFB130A,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000232948,DEFB130A,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000232948,DEFB130A,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000232948,DEFB130A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000232948,DEFB130A,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233050,DEFB130B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233050,DEFB130B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233050,DEFB130B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233050,DEFB130B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233050,DEFB130B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"retina: 98.9967% (minimum 99%, Missing)",0.0419571,0.0273046,-3.34448e-05,9,80,unavailable,1.5,0.4,1.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233056,ERVH48-1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive noncoding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,,0.341957,0.297305,0.239967,9,80,unavailable,1.5,0.4,1.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233056,ERVH48-1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive noncoding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,,0.341957,0.297305,0.239967,9,80,unavailable,1.5,0.4,1.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233056,ERVH48-1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive noncoding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,,0.341957,0.297305,0.239967,9,80,unavailable,1.5,0.4,1.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233056,ERVH48-1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive noncoding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,,0.341957,0.297305,0.239967,9,80,unavailable,1.5,0.4,1.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233056,ERVH48-1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive noncoding;Gong et al., Nature Communications (2021)"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233412,OR5H15,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233412,OR5H15,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233412,OR5H15,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233412,OR5H15,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233412,OR5H15,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 95.4545% (minimum 99%, Missing); bone marrow: 95.4545% (minimum 99%, Missing); cerebellum: 91.3043% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); kidney: 95.4545% (minimum 99%, Missing); retina: 95.4545% (minimum 99%, Missing); skeletal muscle: 95.4545% (minimum 99%, Missing); skin: 91.3043% (minimum 95%, Missing)",-0.0369565,0.03,-0.0769565,0,80,unavailable,0.2,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233436,BTBD18,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.263043,0.3,0.163043,0,80,unavailable,0.2,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233436,BTBD18,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.263043,0.3,0.163043,0,80,unavailable,0.2,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233436,BTBD18,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.263043,0.3,0.163043,0,80,unavailable,0.2,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233436,BTBD18,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
True,compatible,,True,True,True,,0.263043,0.3,0.163043,0,80,unavailable,0.2,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233436,BTBD18,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 90.0000% (minimum 99%, Missing)",0.05,0.03,-0.09,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233701,PRR23C,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.15,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233701,PRR23C,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.15,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233701,PRR23C,grid_revised,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.15,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233701,PRR23C,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.15,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233701,PRR23C,current_fixed,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233802,TRIM49D2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233802,TRIM49D2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233802,TRIM49D2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233802,TRIM49D2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233802,TRIM49D2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233803,TSPY4,admission_only,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233803,TSPY4,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233803,TSPY4,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233803,TSPY4,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.34375,0.3,0.246865,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000233803,TSPY4,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233917,POTEB,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233917,POTEB,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233917,POTEB,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233917,POTEB,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000233917,POTEB,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.042674,0.03,0.00632353,0,2,partial,0.2,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234068,PAGE2,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.342674,0.3,0.246324,0,2,partial,0.2,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234068,PAGE2,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.342674,0.3,0.246324,0,2,partial,0.2,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234068,PAGE2,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.342674,0.3,0.246324,0,2,partial,0.2,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234068,PAGE2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.331884,0.289051,0.242674,0,2,partial,0.2,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234068,PAGE2,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.00888476,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234186,C16orf82,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248885,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234186,C16orf82,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248885,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234186,C16orf82,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248885,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234186,C16orf82,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.248885,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234186,C16orf82,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000234278,PRR20E,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000234278,PRR20E,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000234278,PRR20E,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000234278,PRR20E,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000234278,PRR20E,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 73.1707% (minimum 95%, Missing); adrenal gland: 80.0000% (minimum 99%, Missing); amygdala: 78.9474% (minimum 99%, Missing); basal ganglia: 77.9221% (minimum 99%, Missing); bone marrow: 88.2353% (minimum 99%, Missing); cerebellum: 57.1429% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 74.0741% (minimum 97%, Missing); duodenum: 84.5070% (minimum 99%, Missing); esophagus: 75.9494% (minimum 97%, Missing); heart muscle: 69.7674% (minimum 99%, Missing); hippocampal formation: 78.9474% (minimum 99%, Missing); hypothalamus: 80.0000% (minimum 99%, Missing); kidney: 73.1707% (minimum 99%, Missing); liver: 81.0811% (minimum 99%, Missing); lung: 75.9494% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 77.9221% (minimum 99%, Missing); pancreas: 78.9474% (minimum 99%, Missing); parathyroid gland: 71.4286% (minimum 97%, Missing); pituitary gland: 70.5882% (minimum 99%, Missing); rectum: 84.5070% (minimum 97%, Missing); retina: 46.5116% (minimum 99%, Missing); salivary gland: 74.0741% (minimum 97%, Missing); skeletal muscle: 74.0741% (minimum 99%, Uncertain); skin: 63.8298% (minimum 95%, Missing); small intestine: 76.9231% (minimum 99%, Missing); smooth muscle: 73.1707% (minimum 99%, Uncertain); spinal cord: 76.9231% (minimum 99%, Missing); spleen: 65.9341% (minimum 95%, Uncertain); stomach: 77.9221% (minimum 97%, Missing); thymus: 64.5161% (minimum 95%, Missing); thyroid gland: 62.5000% (minimum 95%, Missing); tongue: 66.6667% (minimum 97%, Missing); urinary bladder: 76.9231% (minimum 97%, Missing)",-0.325,-0.303333,-0.524884,0,6,partial,6.9,3,3.6,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); lymph node: 3 nTPM (protected, limit 2); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234284,ZNF879,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 57.1429% (minimum 75%, Missing); heart muscle: 69.7674% (minimum 75%, Missing); kidney: 73.1707% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); retina: 46.5116% (minimum 75%, Missing); skeletal muscle: 74.0741% (minimum 75%, Uncertain); skin: 63.8298% (minimum 65%, Missing); smooth muscle: 73.1707% (minimum 75%, Uncertain); thymus: 64.5161% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing)",-0.025,-0.0333333,-0.284884,0,6,partial,6.9,3,3.6,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); lymph node: 3 nTPM (protected, limit 2); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234284,ZNF879,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 57.1429% (minimum 75%, Missing); heart muscle: 69.7674% (minimum 75%, Missing); kidney: 73.1707% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); retina: 46.5116% (minimum 75%, Missing); skeletal muscle: 74.0741% (minimum 75%, Uncertain); skin: 63.8298% (minimum 65%, Missing); smooth muscle: 73.1707% (minimum 75%, Uncertain); thymus: 64.5161% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing)",-0.025,-0.0333333,-0.284884,0,6,partial,6.9,3,3.6,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234284,ZNF879,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 57.1429% (minimum 75%, Missing); heart muscle: 69.7674% (minimum 75%, Missing); kidney: 73.1707% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); retina: 46.5116% (minimum 75%, Missing); skeletal muscle: 74.0741% (minimum 75%, Uncertain); skin: 63.8298% (minimum 65%, Missing); smooth muscle: 73.1707% (minimum 75%, Uncertain); thymus: 64.5161% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing)",-0.025,-0.0333333,-0.284884,0,6,partial,6.9,3,3.6,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234284,ZNF879,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 57.1429% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 69.7674% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.1707% (minimum 75%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.5882% (minimum 75%, Baseline (adaptation disabled)); retina: 46.5116% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 74.0741% (minimum 75%, Baseline (adaptation disabled)); skin: 63.8298% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 73.1707% (minimum 75%, Baseline (adaptation disabled)); thymus: 64.5161% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.5000% (minimum 65%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 70%, Baseline (adaptation disabled))",-0.025,-0.0333333,-0.284884,0,6,partial,6.9,3,3.6,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234284,ZNF879,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"adipose tissue: 60.8696% (minimum 95%, Missing); adrenal gland: 70.0000% (minimum 99%, Missing); amygdala: 93.3333% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 93.3333% (minimum 99%, Missing); cerebral cortex: 93.3333% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 93.3333% (minimum 99%, Missing); esophagus: 51.8519% (minimum 97%, Missing); heart muscle: 73.6842% (minimum 99%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing); hypothalamus: 93.3333% (minimum 99%, Missing); kidney: 87.5000% (minimum 99%, Missing); liver: 42.4242% (minimum 99%, Missing); lung: 60.8696% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 87.5000% (minimum 99%, Missing); pancreas: 58.3333% (minimum 99%, Missing); pituitary gland: 82.3529% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 93.3333% (minimum 99%, Missing); skin: 70.0000% (minimum 95%, Missing); small intestine: 63.6364% (minimum 99%, Missing); spinal cord: 82.3529% (minimum 99%, Missing); spleen: 48.2759% (minimum 95%, Missing); stomach: 70.0000% (minimum 97%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); urinary bladder: 82.3529% (minimum 97%, Missing)",-0.467241,-0.47,-0.565758,0,3,partial,1.9,1.4,1.5,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234289,H2BC12L,admission_only,False,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"adipose tissue: 60.8696% (minimum 65%, Missing); adrenal gland: 70.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 51.8519% (minimum 70%, Missing); heart muscle: 73.6842% (minimum 75%, Missing); liver: 42.4242% (minimum 75%, Missing); lung: 60.8696% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 58.3333% (minimum 75%, Missing); small intestine: 63.6364% (minimum 75%, Missing); spleen: 48.2759% (minimum 65%, Missing)",-0.167241,-0.2,-0.325758,0,3,partial,1.9,1.4,1.5,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234289,H2BC12L,selectivity_revised,False,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"adipose tissue: 60.8696% (minimum 65%, Missing); adrenal gland: 70.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 51.8519% (minimum 70%, Missing); heart muscle: 73.6842% (minimum 75%, Missing); liver: 42.4242% (minimum 75%, Missing); lung: 60.8696% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 58.3333% (minimum 75%, Missing); small intestine: 63.6364% (minimum 75%, Missing); spleen: 48.2759% (minimum 65%, Missing)",-0.167241,-0.2,-0.325758,0,3,partial,1.9,1.4,1.5,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234289,H2BC12L,grid_revised,False,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"adipose tissue: 60.8696% (minimum 65%, Missing); adrenal gland: 70.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 51.8519% (minimum 70%, Missing); heart muscle: 73.6842% (minimum 75%, Missing); liver: 42.4242% (minimum 75%, Missing); lung: 60.8696% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 58.3333% (minimum 75%, Missing); small intestine: 63.6364% (minimum 75%, Missing); spleen: 48.2759% (minimum 65%, Missing)",-0.167241,-0.2,-0.325758,0,3,partial,1.9,1.4,1.5,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234289,H2BC12L,current_adaptive,False,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"adipose tissue: 60.8696% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 70.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 70%, Baseline (adaptation disabled)); esophagus: 51.8519% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 73.6842% (minimum 75%, Baseline (adaptation disabled)); liver: 42.4242% (minimum 75%, Baseline (adaptation disabled)); lung: 60.8696% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); pancreas: 58.3333% (minimum 75%, Baseline (adaptation disabled)); small intestine: 63.6364% (minimum 75%, Baseline (adaptation disabled)); spleen: 48.2759% (minimum 65%, Baseline (adaptation disabled))",-0.167241,-0.2,-0.325758,0,3,partial,1.9,1.4,1.5,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234289,H2BC12L,current_fixed,False,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4887% (minimum 99%, Missing); amygdala: 98.7374% (minimum 99%, Missing); basal ganglia: 97.2637% (minimum 99%, Missing); bone marrow: 98.7374% (minimum 99%, Missing); cerebellum: 93.9904% (minimum 99%, Missing); cerebral cortex: 96.5432% (minimum 99%, Missing); choroid plexus: 97.9950% (minimum 99%, Missing); duodenum: 98.2412% (minimum 99%, Missing); heart muscle: 98.4887% (minimum 99%, Missing); hippocampal formation: 98.2412% (minimum 99%, Missing); hypothalamus: 93.0952% (minimum 99%, Missing); kidney: 97.7500% (minimum 99%, Missing); lung: 97.7500% (minimum 99%, Missing); midbrain: 97.7500% (minimum 99%, Missing); pancreas: 98.7374% (minimum 99%, Missing); pituitary gland: 80.7851% (minimum 99%, Missing); skeletal muscle: 98.4887% (minimum 99%, Missing); small intestine: 98.4887% (minimum 99%, Missing); spinal cord: 98.7374% (minimum 99%, Missing)",0.0130542,0.0124121,-0.182149,0,80,unavailable,9.3,0.7,1.5,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234409,CCDC188,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.313054,0.282412,0.0578512,0,80,unavailable,9.3,0.7,1.5,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234409,CCDC188,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.313054,0.282412,0.0578512,0,80,unavailable,9.3,0.7,1.5,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234409,CCDC188,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.313054,0.282412,0.0578512,0,80,unavailable,9.3,0.7,1.5,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234409,CCDC188,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.313054,0.282412,0.0578512,0,80,unavailable,9.3,0.7,1.5,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234409,CCDC188,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.05,0.03,0.01,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234414,RBMY1A1,admission_only,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234414,RBMY1A1,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234414,RBMY1A1,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234414,RBMY1A1,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234414,RBMY1A1,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 94.1176% (minimum 97%, Missing); kidney: 94.1176% (minimum 99%, Missing); liver: 94.1176% (minimum 99%, Missing); lung: 94.1176% (minimum 99%, Missing); pancreas: 94.1176% (minimum 99%, Missing); retina: 76.1905% (minimum 99%, Missing); skin: 88.8889% (minimum 95%, Missing); urinary bladder: 94.1176% (minimum 97%, Missing)",-0.0611111,-0.0288235,-0.228095,0,80,unavailable,0.5,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234469,CLDN34,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.238889,0.241176,0.0119048,0,80,unavailable,0.5,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234469,CLDN34,selectivity_revised,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.238889,0.241176,0.0119048,0,80,unavailable,0.5,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234469,CLDN34,grid_revised,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.238889,0.241176,0.0119048,0,80,unavailable,0.5,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234469,CLDN34,current_adaptive,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.238889,0.241176,0.0119048,0,80,unavailable,0.5,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234469,CLDN34,current_fixed,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.9359% (minimum 99%, Missing); lung: 97.7528% (minimum 99%, Missing); midbrain: 98.9105% (minimum 99%, Missing); spinal cord: 96.5326% (minimum 99%, Missing)",0.0335139,0.0195735,-0.0246741,0,80,unavailable,7.5,2.2,3.5,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234511,C5orf58,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333514,0.289573,0.215326,0,80,unavailable,7.5,2.2,3.5,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234511,C5orf58,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333514,0.289573,0.215326,0,80,unavailable,7.5,2.2,3.5,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234511,C5orf58,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333514,0.289573,0.215326,0,80,unavailable,7.5,2.2,3.5,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234511,C5orf58,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333514,0.289573,0.215326,0,80,unavailable,7.5,2.2,3.5,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234511,C5orf58,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.0243925,0.01,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234776,FREY1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.294393,0.25,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234776,FREY1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.294393,0.25,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234776,FREY1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.294393,0.25,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234776,FREY1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.294393,0.25,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000234776,FREY1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"colon: 93.6170% (minimum 97%, Missing); rectum: 93.6170% (minimum 97%, Missing)",0.05,-0.0338298,0.01,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000234828,IQCM,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.23617,0.25,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000234828,IQCM,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.23617,0.25,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000234828,IQCM,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.23617,0.25,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000234828,IQCM,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.23617,0.25,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000234828,IQCM,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"pituitary gland: 83.3333% (minimum 99%, Missing)",0.05,0.03,-0.156667,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000235608,NKX1-1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0833333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000235608,NKX1-1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0833333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000235608,NKX1-1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0833333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000235608,NKX1-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0833333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000235608,NKX1-1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.9669% (minimum 99%, Missing)",0.045842,0.0217184,-0.000330579,0,80,unavailable,0.5,0.4,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000235631,RNF148,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345842,0.291718,0.239669,0,80,unavailable,0.5,0.4,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000235631,RNF148,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345842,0.291718,0.239669,0,80,unavailable,0.5,0.4,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000235631,RNF148,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345842,0.291718,0.239669,0,80,unavailable,0.5,0.4,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000235631,RNF148,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345842,0.291718,0.239669,0,80,unavailable,0.5,0.4,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000235631,RNF148,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000235699,CXorf51B,admission_only,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000235699,CXorf51B,selectivity_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000235699,CXorf51B,grid_revised,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000235699,CXorf51B,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000235699,CXorf51B,current_fixed,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236027,PATE3,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236027,PATE3,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236027,PATE3,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236027,PATE3,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236027,PATE3,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 60.0000% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); retina: 75.0000% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing)",-0.2,0.03,-0.39,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000236032,OR5H14,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 60.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); retina: 75.0000% (minimum 75%, Missing)",0.1,0.3,-0.15,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000236032,OR5H14,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 60.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); retina: 75.0000% (minimum 75%, Missing)",0.1,0.3,-0.15,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000236032,OR5H14,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 60.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); retina: 75.0000% (minimum 75%, Missing)",0.1,0.3,-0.15,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000236032,OR5H14,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 60.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 75%, Baseline (adaptation disabled))",0.1,0.3,-0.15,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000236032,OR5H14,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236126,CT47A3,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236126,CT47A3,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236126,CT47A3,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236126,CT47A3,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236126,CT47A3,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.3810% (minimum 99%, Missing)",0.05,0.0256272,-0.00619048,0,4,partial,1.7,8.3,0,"stomach: 8.3 nTPM (protected, limit 6); retina: 1.7 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236362,GAGE12F,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.23381,0,4,partial,1.7,8.3,0,"stomach: 8.3 nTPM (protected, limit 6); retina: 1.7 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236362,GAGE12F,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.23381,0,4,partial,1.7,8.3,0,"stomach: 8.3 nTPM (protected, limit 6); retina: 1.7 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236362,GAGE12F,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.23381,0,4,partial,1.7,8.3,0,"stomach: 8.3 nTPM (protected, limit 6); retina: 1.7 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236362,GAGE12F,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.225627,0.23381,0,4,partial,1.7,8.3,0,"stomach: 8.3 nTPM (protected, limit 3); retina: 1.7 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236362,GAGE12F,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236371,CT47A1,admission_only,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236371,CT47A1,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236371,CT47A1,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236371,CT47A1,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236371,CT47A1,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000236396,SLC35G4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000236396,SLC35G4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000236396,SLC35G4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000236396,SLC35G4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000236396,SLC35G4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236424,TSPY10,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236424,TSPY10,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236424,TSPY10,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236424,TSPY10,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.3,0.3,0.25,0,1,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236424,TSPY10,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236446,CT47B1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236446,CT47B1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236446,CT47B1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236446,CT47B1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236446,CT47B1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 97.8678% (minimum 99%, Missing); cerebellum: 98.9935% (minimum 99%, Missing); hypothalamus: 98.8514% (minimum 99%, Missing); pituitary gland: 98.9224% (minimum 99%, Missing)",0.0413607,0.0121683,-0.011322,0,80,unavailable,3,2.5,1.2,"basal ganglia: 3 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236737,GAGE12B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341361,0.282168,0.228678,0,80,unavailable,3,2.5,1.2,"basal ganglia: 3 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236737,GAGE12B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341361,0.282168,0.228678,0,80,unavailable,3,2.5,1.2,"basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236737,GAGE12B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341361,0.282168,0.228678,0,80,unavailable,3,2.5,1.2,"basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236737,GAGE12B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341361,0.282168,0.228678,0,80,unavailable,3,2.5,1.2,"basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236737,GAGE12B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"small intestine: 98.7805% (minimum 99%, Missing)",0.0378049,0.00590361,-0.00219512,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236761,CTAGE9,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.337805,0.275904,0.237805,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236761,CTAGE9,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.337805,0.275904,0.237805,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236761,CTAGE9,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.337805,0.275904,0.237805,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236761,CTAGE9,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.337805,0.275904,0.237805,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236761,CTAGE9,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236980,CIMIP7,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236980,CIMIP7,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236980,CIMIP7,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236980,CIMIP7,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000236980,CIMIP7,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237136,C4orf51,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237136,C4orf51,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237136,C4orf51,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237136,C4orf51,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237136,C4orf51,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237247,MBD3L5,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237247,MBD3L5,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237247,MBD3L5,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237247,MBD3L5,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237247,MBD3L5,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 95.9459% (minimum 99%, Missing)",0.05,0.03,-0.0305405,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237452,MEIOSIN,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.209459,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237452,MEIOSIN,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.209459,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237452,MEIOSIN,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.209459,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237452,MEIOSIN,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.209459,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237452,MEIOSIN,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237521,OR7E24,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237521,OR7E24,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237521,OR7E24,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237521,OR7E24,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237521,OR7E24,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00488055,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237524,TEX51,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.244881,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237524,TEX51,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.244881,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237524,TEX51,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.244881,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237524,TEX51,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.244881,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237524,TEX51,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237671,GAGE12C,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237671,GAGE12C,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237671,GAGE12C,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237671,GAGE12C,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237671,GAGE12C,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237957,CT47A5,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237957,CT47A5,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237957,CT47A5,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237957,CT47A5,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000237957,CT47A5,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.05,0.0163946,0.01,9,2,partial,0,0.2,0.1,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238074,TSPY9,admission_only,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.35,0.286395,0.25,9,2,partial,0,0.2,0.1,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238074,TSPY9,selectivity_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.35,0.286395,0.25,9,2,partial,0,0.2,0.1,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238074,TSPY9,grid_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.35,0.286395,0.25,9,2,partial,0,0.2,0.1,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238074,TSPY9,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.343151,0.286395,0.25,9,2,partial,0,0.2,0.1,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238074,TSPY9,current_fixed,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.7143% (minimum 99%, Missing); basal ganglia: 94.3662% (minimum 99%, Missing); bone marrow: 95.7143% (minimum 97%, Supported); cerebellum: 94.3662% (minimum 97%, Supported); cerebral cortex: 93.0556% (minimum 97%, Supported); choroid plexus: 95.7143% (minimum 99%, Missing); colon: 95.7143% (minimum 97%, Missing); hippocampal formation: 95.7143% (minimum 99%, Missing); hypothalamus: 95.7143% (minimum 99%, Missing); kidney: 91.7808% (minimum 97%, Supported); lung: 94.3662% (minimum 97%, Supported); midbrain: 98.5294% (minimum 99%, Missing); pituitary gland: 90.5405% (minimum 99%, Missing); rectum: 93.0556% (minimum 97%, Missing); retina: 94.3662% (minimum 99%, Missing); skeletal muscle: 91.7808% (minimum 97%, Supported); small intestine: 95.7143% (minimum 99%, Missing); smooth muscle: 95.7143% (minimum 97%, Supported); spinal cord: 97.1014% (minimum 99%, Missing); thymus: 90.5405% (minimum 95%, Missing); tongue: 91.7808% (minimum 97%, Missing)",-0.0445946,-0.0521918,-0.0845946,0,9,partial,0.7,0.6,0.7,,small intestine / enterocytes - Gradient: Ascending (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238083,LRRC37A2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.255405,0.217808,0.155405,0,9,partial,0.7,0.6,0.7,,small intestine / enterocytes - Gradient: Ascending (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238083,LRRC37A2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.255405,0.217808,0.155405,0,9,partial,0.7,0.6,0.7,,small intestine / enterocytes - Gradient: Ascending (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238083,LRRC37A2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.255405,0.217808,0.155405,0,9,partial,0.7,0.6,0.7,,small intestine / enterocytes - Gradient: Ascending (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238083,LRRC37A2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.255405,0.217808,0.155405,0,9,partial,0.7,0.6,0.7,,small intestine / enterocytes - Gradient: Ascending (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238083,LRRC37A2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000238205,MPC1L,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000238205,MPC1L,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000238205,MPC1L,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000238205,MPC1L,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000238205,MPC1L,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.2203% (minimum 97%, Supported)",0.0463768,0.0192086,-0.0377966,0,2,partial,4,0.6,0.7,"bone marrow: 4 nTPM (vital, limit 3)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238269,PAGE2B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346377,0.289209,0.246377,0,2,partial,4,0.6,0.7,"bone marrow: 4 nTPM (vital, limit 3)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238269,PAGE2B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346377,0.289209,0.246377,0,2,partial,4,0.6,0.7,"bone marrow: 4 nTPM (vital, limit 3)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238269,PAGE2B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346377,0.289209,0.246377,0,2,partial,4,0.6,0.7,"bone marrow: 4 nTPM (vital, limit 3)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238269,PAGE2B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.337433,0.289209,0.182203,0,2,partial,4,0.6,0.7,"bone marrow: 4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000238269,PAGE2B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.6973% (minimum 95%, Missing); adrenal gland: 58.5007% (minimum 99%, Missing); amygdala: 65.1267% (minimum 99%, Missing); basal ganglia: 62.0739% (minimum 99%, Missing); bone marrow: 57.5000% (minimum 99%, Missing); cerebellum: 47.8118% (minimum 99%, Missing); cerebral cortex: 60.5263% (minimum 99%, Missing); choroid plexus: 60.4426% (minimum 99%, Missing); colon: 60.6103% (minimum 97%, Missing); duodenum: 74.1935% (minimum 99%, Missing); esophagus: 56.9752% (minimum 97%, Missing); heart muscle: 57.5758% (minimum 99%, Missing); hippocampal formation: 64.6450% (minimum 99%, Missing); hypothalamus: 64.9331% (minimum 99%, Missing); kidney: 47.0905% (minimum 99%, Missing); liver: 52.5240% (minimum 99%, Missing); lung: 62.3395% (minimum 99%, Missing); lymph node: 61.2903% (minimum 97%, Missing); midbrain: 66.3126% (minimum 99%, Missing); pancreas: 56.9010% (minimum 99%, Missing); parathyroid gland: 72.1122% (minimum 97%, Missing); pituitary gland: 56.5330% (minimum 99%, Missing); rectum: 71.2887% (minimum 97%, Missing); retina: 55.7398% (minimum 99%, Missing); salivary gland: 64.0762% (minimum 97%, Missing); skeletal muscle: 60.4426% (minimum 99%, Missing); skin: 61.3764% (minimum 95%, Missing); small intestine: 60.6944% (minimum 99%, Missing); smooth muscle: 74.3197% (minimum 99%, Missing); spinal cord: 67.4383% (minimum 99%, Missing); spleen: 52.5872% (minimum 95%, Missing); stomach: 59.9451% (minimum 97%, Missing); thymus: 63.6099% (minimum 95%, Missing); thyroid gland: 61.2903% (minimum 95%, Missing); tongue: 79.7445% (minimum 97%, Missing); urinary bladder: 59.7811% (minimum 97%, Missing)",-0.424128,-0.400248,-0.519095,0,5,partial,49.1,33,39.4,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); spleen: 39.4 nTPM (manageable, limit 5); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 2); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 2); stomach: 29.2 nTPM (protected, limit 2); choroid plexus: 28.6 nTPM (vital, limit 1); skeletal muscle: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 2); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 2); thyroid gland: 27.6 nTPM (manageable, limit 5); skin: 27.5 nTPM (manageable, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (manageable, limit 5); thymus: 25 nTPM (manageable, limit 5); salivary gland: 24.5 nTPM (protected, limit 2); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 2); parathyroid gland: 16.9 nTPM (protected, limit 2); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239306,RBM14,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.6973% (minimum 65%, Missing); adrenal gland: 58.5007% (minimum 75%, Missing); amygdala: 65.1267% (minimum 75%, Missing); basal ganglia: 62.0739% (minimum 75%, Missing); bone marrow: 57.5000% (minimum 75%, Missing); cerebellum: 47.8118% (minimum 75%, Missing); cerebral cortex: 60.5263% (minimum 75%, Missing); choroid plexus: 60.4426% (minimum 75%, Missing); colon: 60.6103% (minimum 70%, Missing); duodenum: 74.1935% (minimum 75%, Missing); esophagus: 56.9752% (minimum 70%, Missing); heart muscle: 57.5758% (minimum 75%, Missing); hippocampal formation: 64.6450% (minimum 75%, Missing); hypothalamus: 64.9331% (minimum 75%, Missing); kidney: 47.0905% (minimum 75%, Missing); liver: 52.5240% (minimum 75%, Missing); lung: 62.3395% (minimum 75%, Missing); lymph node: 61.2903% (minimum 70%, Missing); midbrain: 66.3126% (minimum 75%, Missing); pancreas: 56.9010% (minimum 75%, Missing); pituitary gland: 56.5330% (minimum 75%, Missing); retina: 55.7398% (minimum 75%, Missing); salivary gland: 64.0762% (minimum 70%, Missing); skeletal muscle: 60.4426% (minimum 75%, Missing); skin: 61.3764% (minimum 65%, Missing); small intestine: 60.6944% (minimum 75%, Missing); smooth muscle: 74.3197% (minimum 75%, Missing); spinal cord: 67.4383% (minimum 75%, Missing); spleen: 52.5872% (minimum 65%, Missing); stomach: 59.9451% (minimum 70%, Missing); thymus: 63.6099% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); urinary bladder: 59.7811% (minimum 70%, Missing)",-0.124128,-0.130248,-0.279095,0,5,partial,49.1,33,39.4,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); spleen: 39.4 nTPM (manageable, limit 5); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 2); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 2); stomach: 29.2 nTPM (protected, limit 2); choroid plexus: 28.6 nTPM (vital, limit 1); skeletal muscle: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 2); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 2); thyroid gland: 27.6 nTPM (manageable, limit 5); skin: 27.5 nTPM (manageable, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (manageable, limit 5); thymus: 25 nTPM (manageable, limit 5); salivary gland: 24.5 nTPM (protected, limit 2); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 2); parathyroid gland: 16.9 nTPM (protected, limit 2); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239306,RBM14,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.6973% (minimum 65%, Missing); adrenal gland: 58.5007% (minimum 75%, Missing); amygdala: 65.1267% (minimum 75%, Missing); basal ganglia: 62.0739% (minimum 75%, Missing); bone marrow: 57.5000% (minimum 75%, Missing); cerebellum: 47.8118% (minimum 75%, Missing); cerebral cortex: 60.5263% (minimum 75%, Missing); choroid plexus: 60.4426% (minimum 75%, Missing); colon: 60.6103% (minimum 70%, Missing); duodenum: 74.1935% (minimum 75%, Missing); esophagus: 56.9752% (minimum 70%, Missing); heart muscle: 57.5758% (minimum 75%, Missing); hippocampal formation: 64.6450% (minimum 75%, Missing); hypothalamus: 64.9331% (minimum 75%, Missing); kidney: 47.0905% (minimum 75%, Missing); liver: 52.5240% (minimum 75%, Missing); lung: 62.3395% (minimum 75%, Missing); lymph node: 61.2903% (minimum 70%, Missing); midbrain: 66.3126% (minimum 75%, Missing); pancreas: 56.9010% (minimum 75%, Missing); pituitary gland: 56.5330% (minimum 75%, Missing); retina: 55.7398% (minimum 75%, Missing); salivary gland: 64.0762% (minimum 70%, Missing); skeletal muscle: 60.4426% (minimum 75%, Missing); skin: 61.3764% (minimum 65%, Missing); small intestine: 60.6944% (minimum 75%, Missing); smooth muscle: 74.3197% (minimum 75%, Missing); spinal cord: 67.4383% (minimum 75%, Missing); spleen: 52.5872% (minimum 65%, Missing); stomach: 59.9451% (minimum 70%, Missing); thymus: 63.6099% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); urinary bladder: 59.7811% (minimum 70%, Missing)",-0.124128,-0.130248,-0.279095,0,5,partial,49.1,33,39.4,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); spleen: 39.4 nTPM (manageable, limit 5); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 3); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 3); stomach: 29.2 nTPM (protected, limit 3); choroid plexus: 28.6 nTPM (vital, limit 1); skeletal muscle: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 3); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 3); thyroid gland: 27.6 nTPM (manageable, limit 5); skin: 27.5 nTPM (manageable, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (manageable, limit 5); thymus: 25 nTPM (manageable, limit 5); salivary gland: 24.5 nTPM (protected, limit 3); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 3); parathyroid gland: 16.9 nTPM (protected, limit 3); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239306,RBM14,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.6973% (minimum 65%, Missing); adrenal gland: 58.5007% (minimum 75%, Missing); amygdala: 65.1267% (minimum 75%, Missing); basal ganglia: 62.0739% (minimum 75%, Missing); bone marrow: 57.5000% (minimum 75%, Missing); cerebellum: 47.8118% (minimum 75%, Missing); cerebral cortex: 60.5263% (minimum 75%, Missing); choroid plexus: 60.4426% (minimum 75%, Missing); colon: 60.6103% (minimum 70%, Missing); duodenum: 74.1935% (minimum 75%, Missing); esophagus: 56.9752% (minimum 70%, Missing); heart muscle: 57.5758% (minimum 75%, Missing); hippocampal formation: 64.6450% (minimum 75%, Missing); hypothalamus: 64.9331% (minimum 75%, Missing); kidney: 47.0905% (minimum 75%, Missing); liver: 52.5240% (minimum 75%, Missing); lung: 62.3395% (minimum 75%, Missing); lymph node: 61.2903% (minimum 70%, Missing); midbrain: 66.3126% (minimum 75%, Missing); pancreas: 56.9010% (minimum 75%, Missing); pituitary gland: 56.5330% (minimum 75%, Missing); retina: 55.7398% (minimum 75%, Missing); salivary gland: 64.0762% (minimum 70%, Missing); skeletal muscle: 60.4426% (minimum 75%, Missing); skin: 61.3764% (minimum 65%, Missing); small intestine: 60.6944% (minimum 75%, Missing); smooth muscle: 74.3197% (minimum 75%, Missing); spinal cord: 67.4383% (minimum 75%, Missing); spleen: 52.5872% (minimum 65%, Missing); stomach: 59.9451% (minimum 70%, Missing); thymus: 63.6099% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); urinary bladder: 59.7811% (minimum 70%, Missing)",-0.124128,-0.130248,-0.279095,0,5,partial,49.1,33,39.4,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); spleen: 39.4 nTPM (manageable, limit 5); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 3); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 3); stomach: 29.2 nTPM (protected, limit 3); choroid plexus: 28.6 nTPM (vital, limit 1); skeletal muscle: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 3); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 3); thyroid gland: 27.6 nTPM (manageable, limit 5); skin: 27.5 nTPM (manageable, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (manageable, limit 5); thymus: 25 nTPM (manageable, limit 5); salivary gland: 24.5 nTPM (protected, limit 3); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 3); parathyroid gland: 16.9 nTPM (protected, limit 3); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239306,RBM14,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.6973% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 58.5007% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.1267% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.0739% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 57.5000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 47.8118% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.5263% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.4426% (minimum 75%, Baseline (adaptation disabled)); colon: 60.6103% (minimum 70%, Baseline (adaptation disabled)); duodenum: 74.1935% (minimum 75%, Baseline (adaptation disabled)); esophagus: 56.9752% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 57.5758% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.6450% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 64.9331% (minimum 75%, Baseline (adaptation disabled)); kidney: 47.0905% (minimum 75%, Baseline (adaptation disabled)); liver: 52.5240% (minimum 75%, Baseline (adaptation disabled)); lung: 62.3395% (minimum 75%, Baseline (adaptation disabled)); lymph node: 61.2903% (minimum 70%, Baseline (adaptation disabled)); midbrain: 66.3126% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.9010% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 56.5330% (minimum 75%, Baseline (adaptation disabled)); retina: 55.7398% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 64.0762% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 60.4426% (minimum 75%, Baseline (adaptation disabled)); skin: 61.3764% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.6944% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 74.3197% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.4383% (minimum 75%, Baseline (adaptation disabled)); spleen: 52.5872% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.9451% (minimum 70%, Baseline (adaptation disabled)); thymus: 63.6099% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 61.2903% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 59.7811% (minimum 70%, Baseline (adaptation disabled))",-0.124128,-0.130248,-0.279095,0,5,partial,49.1,33,39.4,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); spleen: 39.4 nTPM (manageable, limit 5); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 3); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 3); stomach: 29.2 nTPM (protected, limit 3); choroid plexus: 28.6 nTPM (vital, limit 1); skeletal muscle: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 3); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 3); thyroid gland: 27.6 nTPM (manageable, limit 5); skin: 27.5 nTPM (manageable, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (manageable, limit 5); thymus: 25 nTPM (manageable, limit 5); salivary gland: 24.5 nTPM (protected, limit 3); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 3); parathyroid gland: 16.9 nTPM (protected, limit 3); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239306,RBM14,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 95%, Missing); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 24.0000% (minimum 99%, Missing); cerebellum: 54.5455% (minimum 99%, Missing); cerebral cortex: 60.0000% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 60.0000% (minimum 97%, Missing); heart muscle: 13.9535% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 66.6667% (minimum 99%, Missing); lung: 54.5455% (minimum 99%, Missing); lymph node: 46.1538% (minimum 97%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 28.5714% (minimum 99%, Missing); pituitary gland: 60.0000% (minimum 99%, Missing); retina: 27.2727% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing); skeletal muscle: 2.1661% (minimum 99%, Missing); skin: 42.8571% (minimum 95%, Missing); small intestine: 54.5455% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 54.5455% (minimum 97%, Missing); thyroid gland: 60.0000% (minimum 95%, Missing); tongue: 3.3520% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",-0.521429,-0.93648,-0.968339,0,80,unavailable,27.1,17.3,0.8,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 2); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239388,ASB14,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 24.0000% (minimum 75%, Missing); cerebellum: 54.5455% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); esophagus: 60.0000% (minimum 70%, Missing); heart muscle: 13.9535% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lung: 54.5455% (minimum 75%, Missing); lymph node: 46.1538% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 28.5714% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 27.2727% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 2.1661% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 54.5455% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 54.5455% (minimum 70%, Missing); thyroid gland: 60.0000% (minimum 65%, Missing); tongue: 3.3520% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.221429,-0.66648,-0.728339,0,80,unavailable,27.1,17.3,0.8,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 2); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239388,ASB14,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 24.0000% (minimum 75%, Missing); cerebellum: 54.5455% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); esophagus: 60.0000% (minimum 70%, Missing); heart muscle: 13.9535% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lung: 54.5455% (minimum 75%, Missing); lymph node: 46.1538% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 28.5714% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 27.2727% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 2.1661% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 54.5455% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 54.5455% (minimum 70%, Missing); thyroid gland: 60.0000% (minimum 65%, Missing); tongue: 3.3520% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.221429,-0.66648,-0.728339,0,80,unavailable,27.1,17.3,0.8,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 3); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239388,ASB14,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 24.0000% (minimum 75%, Missing); cerebellum: 54.5455% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); esophagus: 60.0000% (minimum 70%, Missing); heart muscle: 13.9535% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lung: 54.5455% (minimum 75%, Missing); lymph node: 46.1538% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 28.5714% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 27.2727% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 2.1661% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 54.5455% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 54.5455% (minimum 70%, Missing); thyroid gland: 60.0000% (minimum 65%, Missing); tongue: 3.3520% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.221429,-0.66648,-0.728339,0,80,unavailable,27.1,17.3,0.8,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 3); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239388,ASB14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 75%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 24.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.5455% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 60.0000% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 13.9535% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lung: 54.5455% (minimum 75%, Baseline (adaptation disabled)); lymph node: 46.1538% (minimum 70%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 75%, Baseline (adaptation disabled)); pancreas: 28.5714% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 27.2727% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 2.1661% (minimum 75%, Baseline (adaptation disabled)); skin: 42.8571% (minimum 65%, Baseline (adaptation disabled)); small intestine: 54.5455% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.5455% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 60.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 3.3520% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 70%, Baseline (adaptation disabled))",-0.221429,-0.66648,-0.728339,0,80,unavailable,27.1,17.3,0.8,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 3); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239388,ASB14,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Missing); adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 33.3333% (minimum 99%, Missing); basal ganglia: 31.2500% (minimum 99%, Missing); cerebellum: 21.7391% (minimum 99%, Missing); cerebral cortex: 26.3158% (minimum 99%, Missing); hippocampal formation: 31.2500% (minimum 99%, Missing); hypothalamus: 38.4615% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 71.4286% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 83.3333% (minimum 97%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 45.4545% (minimum 99%, Missing); parathyroid gland: 12.8205% (minimum 97%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); retina: 31.2500% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spinal cord: 55.5556% (minimum 99%, Missing); thyroid gland: 71.4286% (minimum 95%, Missing)",-0.235714,-0.841795,-0.772609,0,80,unavailable,1.8,3.4,0.2,"parathyroid gland: 3.4 nTPM (protected, limit 2); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239389,PCDHA13,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 31.2500% (minimum 75%, Missing); cerebellum: 21.7391% (minimum 75%, Missing); cerebral cortex: 26.3158% (minimum 75%, Missing); hippocampal formation: 31.2500% (minimum 75%, Missing); hypothalamus: 38.4615% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 45.4545% (minimum 75%, Missing); parathyroid gland: 12.8205% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 31.2500% (minimum 75%, Missing); spinal cord: 55.5556% (minimum 75%, Missing)",0.0642857,-0.571795,-0.532609,0,80,unavailable,1.8,3.4,0.2,"parathyroid gland: 3.4 nTPM (protected, limit 2); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239389,PCDHA13,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 31.2500% (minimum 75%, Missing); cerebellum: 21.7391% (minimum 75%, Missing); cerebral cortex: 26.3158% (minimum 75%, Missing); hippocampal formation: 31.2500% (minimum 75%, Missing); hypothalamus: 38.4615% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 45.4545% (minimum 75%, Missing); parathyroid gland: 12.8205% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 31.2500% (minimum 75%, Missing); spinal cord: 55.5556% (minimum 75%, Missing)",0.0642857,-0.571795,-0.532609,0,80,unavailable,1.8,3.4,0.2,"parathyroid gland: 3.4 nTPM (protected, limit 3); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239389,PCDHA13,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 31.2500% (minimum 75%, Missing); cerebellum: 21.7391% (minimum 75%, Missing); cerebral cortex: 26.3158% (minimum 75%, Missing); hippocampal formation: 31.2500% (minimum 75%, Missing); hypothalamus: 38.4615% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 45.4545% (minimum 75%, Missing); parathyroid gland: 12.8205% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 31.2500% (minimum 75%, Missing); spinal cord: 55.5556% (minimum 75%, Missing)",0.0642857,-0.571795,-0.532609,0,80,unavailable,1.8,3.4,0.2,"parathyroid gland: 3.4 nTPM (protected, limit 3); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239389,PCDHA13,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 33.3333% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 31.2500% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 21.7391% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 26.3158% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 31.2500% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 38.4615% (minimum 75%, Baseline (adaptation disabled)); liver: 71.4286% (minimum 75%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 45.4545% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 12.8205% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 75%, Baseline (adaptation disabled)); retina: 31.2500% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 55.5556% (minimum 75%, Baseline (adaptation disabled))",0.0642857,-0.571795,-0.532609,0,80,unavailable,1.8,3.4,0.2,"parathyroid gland: 3.4 nTPM (protected, limit 3); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239389,PCDHA13,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239590,OR1J4,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239590,OR1J4,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239590,OR1J4,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239590,OR1J4,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239590,OR1J4,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0430556,0.03,0.00305556,0,4,partial,0.1,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239605,STPG4,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343056,0.3,0.243056,0,4,partial,0.1,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239605,STPG4,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343056,0.3,0.243056,0,4,partial,0.1,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239605,STPG4,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343056,0.3,0.243056,0,4,partial,0.1,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239605,STPG4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.343056,0.286207,0.243056,0,4,partial,0.1,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239605,STPG4,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239620,PRR20G,admission_only,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239620,PRR20G,selectivity_revised,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239620,PRR20G,grid_revised,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239620,PRR20G,current_adaptive,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239620,PRR20G,current_fixed,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.2581% (minimum 95%, Uncertain); adrenal gland: 56.8773% (minimum 99%, Missing); amygdala: 68.6099% (minimum 99%, Missing); basal ganglia: 61.2000% (minimum 99%, Missing); bone marrow: 83.6066% (minimum 99%, Uncertain); cerebellum: 57.9545% (minimum 99%, Missing); cerebral cortex: 66.2338% (minimum 99%, Uncertain); choroid plexus: 50.4950% (minimum 99%, Missing); colon: 69.5455% (minimum 97%, Missing); duodenum: 98.7097% (minimum 99%, Missing); esophagus: 70.1835% (minimum 97%, Uncertain); heart muscle: 82.7027% (minimum 99%, Missing); hippocampal formation: 67.1053% (minimum 99%, Missing); hypothalamus: 60.2362% (minimum 99%, Missing); kidney: 59.0734% (minimum 99%, Uncertain); liver: 70.1835% (minimum 99%, Missing); lung: 75.3695% (minimum 99%, Missing); lymph node: 85.9551% (minimum 97%, Uncertain); midbrain: 69.2308% (minimum 99%, Missing); pancreas: 55.8394% (minimum 99%, Uncertain); parathyroid gland: 96.8354% (minimum 97%, Missing); pituitary gland: 33.7004% (minimum 99%, Missing); rectum: 85.4749% (minimum 97%, Missing); retina: 72.1698% (minimum 99%, Missing); salivary gland: 61.4458% (minimum 97%, Missing); skeletal muscle: 95.6250% (minimum 99%, Missing); skin: 60.9562% (minimum 95%, Uncertain); small intestine: 67.1053% (minimum 99%, Missing); smooth muscle: 93.2927% (minimum 99%, Missing); spinal cord: 70.8333% (minimum 99%, Missing); spleen: 59.5331% (minimum 95%, Uncertain); stomach: 68.0000% (minimum 97%, Missing); thymus: 89.4737% (minimum 95%, Missing); thyroid gland: 51.3423% (minimum 95%, Missing); urinary bladder: 73.9130% (minimum 97%, Missing)",-0.436577,-0.355542,-0.652996,0,2,partial,30.1,9.6,14.5,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (manageable, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 9.8 nTPM (manageable, limit 5); basal ganglia: 9.7 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); esophagus: 6.5 nTPM (protected, limit 2); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); lymph node: 2.5 nTPM (protected, limit 2); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239704,CDRT4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 56.8773% (minimum 75%, Missing); amygdala: 68.6099% (minimum 75%, Missing); basal ganglia: 61.2000% (minimum 75%, Missing); cerebellum: 57.9545% (minimum 75%, Missing); cerebral cortex: 66.2338% (minimum 75%, Uncertain); choroid plexus: 50.4950% (minimum 75%, Missing); colon: 69.5455% (minimum 70%, Missing); hippocampal formation: 67.1053% (minimum 75%, Missing); hypothalamus: 60.2362% (minimum 75%, Missing); kidney: 59.0734% (minimum 75%, Uncertain); liver: 70.1835% (minimum 75%, Missing); midbrain: 69.2308% (minimum 75%, Missing); pancreas: 55.8394% (minimum 75%, Uncertain); pituitary gland: 33.7004% (minimum 75%, Missing); retina: 72.1698% (minimum 75%, Missing); salivary gland: 61.4458% (minimum 70%, Missing); skin: 60.9562% (minimum 65%, Uncertain); small intestine: 67.1053% (minimum 75%, Missing); spinal cord: 70.8333% (minimum 75%, Missing); spleen: 59.5331% (minimum 65%, Uncertain); stomach: 68.0000% (minimum 70%, Missing); thyroid gland: 51.3423% (minimum 65%, Missing)",-0.136577,-0.0855422,-0.412996,0,2,partial,30.1,9.6,14.5,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (manageable, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 9.8 nTPM (manageable, limit 5); basal ganglia: 9.7 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); esophagus: 6.5 nTPM (protected, limit 2); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); lymph node: 2.5 nTPM (protected, limit 2); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239704,CDRT4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 56.8773% (minimum 75%, Missing); amygdala: 68.6099% (minimum 75%, Missing); basal ganglia: 61.2000% (minimum 75%, Missing); cerebellum: 57.9545% (minimum 75%, Missing); cerebral cortex: 66.2338% (minimum 75%, Uncertain); choroid plexus: 50.4950% (minimum 75%, Missing); colon: 69.5455% (minimum 70%, Missing); hippocampal formation: 67.1053% (minimum 75%, Missing); hypothalamus: 60.2362% (minimum 75%, Missing); kidney: 59.0734% (minimum 75%, Uncertain); liver: 70.1835% (minimum 75%, Missing); midbrain: 69.2308% (minimum 75%, Missing); pancreas: 55.8394% (minimum 75%, Uncertain); pituitary gland: 33.7004% (minimum 75%, Missing); retina: 72.1698% (minimum 75%, Missing); salivary gland: 61.4458% (minimum 70%, Missing); skin: 60.9562% (minimum 65%, Uncertain); small intestine: 67.1053% (minimum 75%, Missing); spinal cord: 70.8333% (minimum 75%, Missing); spleen: 59.5331% (minimum 65%, Uncertain); stomach: 68.0000% (minimum 70%, Missing); thyroid gland: 51.3423% (minimum 65%, Missing)",-0.136577,-0.0855422,-0.412996,0,2,partial,30.1,9.6,14.5,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (manageable, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 9.8 nTPM (manageable, limit 5); basal ganglia: 9.7 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); esophagus: 6.5 nTPM (protected, limit 3); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239704,CDRT4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 56.8773% (minimum 75%, Missing); amygdala: 68.6099% (minimum 75%, Missing); basal ganglia: 61.2000% (minimum 75%, Missing); cerebellum: 57.9545% (minimum 75%, Missing); cerebral cortex: 66.2338% (minimum 75%, Uncertain); choroid plexus: 50.4950% (minimum 75%, Missing); colon: 69.5455% (minimum 70%, Missing); hippocampal formation: 67.1053% (minimum 75%, Missing); hypothalamus: 60.2362% (minimum 75%, Missing); kidney: 59.0734% (minimum 75%, Uncertain); liver: 70.1835% (minimum 75%, Missing); midbrain: 69.2308% (minimum 75%, Missing); pancreas: 55.8394% (minimum 75%, Uncertain); pituitary gland: 33.7004% (minimum 75%, Missing); retina: 72.1698% (minimum 75%, Missing); salivary gland: 61.4458% (minimum 70%, Missing); skin: 60.9562% (minimum 65%, Uncertain); small intestine: 67.1053% (minimum 75%, Missing); spinal cord: 70.8333% (minimum 75%, Missing); spleen: 59.5331% (minimum 65%, Uncertain); stomach: 68.0000% (minimum 70%, Missing); thyroid gland: 51.3423% (minimum 65%, Missing)",-0.136577,-0.0855422,-0.412996,0,2,partial,30.1,9.6,14.5,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (manageable, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 9.8 nTPM (manageable, limit 5); basal ganglia: 9.7 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); esophagus: 6.5 nTPM (protected, limit 3); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239704,CDRT4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 56.8773% (minimum 75%, Baseline (adaptation disabled)); amygdala: 68.6099% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.2000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 57.9545% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 66.2338% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 50.4950% (minimum 75%, Baseline (adaptation disabled)); colon: 69.5455% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 67.1053% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 60.2362% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.0734% (minimum 75%, Baseline (adaptation disabled)); liver: 70.1835% (minimum 75%, Baseline (adaptation disabled)); midbrain: 69.2308% (minimum 75%, Baseline (adaptation disabled)); pancreas: 55.8394% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 33.7004% (minimum 75%, Baseline (adaptation disabled)); retina: 72.1698% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 61.4458% (minimum 70%, Baseline (adaptation disabled)); skin: 60.9562% (minimum 65%, Baseline (adaptation disabled)); small intestine: 67.1053% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.8333% (minimum 75%, Baseline (adaptation disabled)); spleen: 59.5331% (minimum 65%, Baseline (adaptation disabled)); stomach: 68.0000% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 51.3423% (minimum 65%, Baseline (adaptation disabled))",-0.136577,-0.0855422,-0.412996,0,2,partial,30.1,9.6,14.5,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (manageable, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 9.8 nTPM (manageable, limit 5); basal ganglia: 9.7 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); esophagus: 6.5 nTPM (protected, limit 3); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239704,CDRT4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.2885% (minimum 90%, Approved); adrenal gland: 46.7480% (minimum 99%, Missing); amygdala: 46.5587% (minimum 99%, Missing); basal ganglia: 45.4545% (minimum 99%, Missing); bone marrow: 53.7383% (minimum 99%, Missing); cerebellum: 47.9167% (minimum 99%, Missing); cerebral cortex: 41.6667% (minimum 99%, Missing); choroid plexus: 60.5263% (minimum 99%, Missing); colon: 47.7178% (minimum 97%, Missing); duodenum: 57.2139% (minimum 99%, Missing); esophagus: 46.7480% (minimum 97%, Missing); heart muscle: 37.2168% (minimum 99%, Missing); hippocampal formation: 46.3710% (minimum 99%, Missing); hypothalamus: 47.9167% (minimum 99%, Missing); kidney: 41.3669% (minimum 99%, Missing); liver: 34.7432% (minimum 99%, Missing); lung: 63.1868% (minimum 99%, Missing); lymph node: 56.6502% (minimum 97%, Missing); midbrain: 54.2453% (minimum 99%, Missing); pancreas: 46.5587% (minimum 99%, Missing); parathyroid gland: 55.2885% (minimum 95%, Approved); pituitary gland: 58.6735% (minimum 99%, Missing); rectum: 54.7619% (minimum 97%, Missing); retina: 68.0473% (minimum 99%, Missing); salivary gland: 56.9307% (minimum 97%, Missing); skeletal muscle: 26.6204% (minimum 99%, Missing); skin: 58.9744% (minimum 95%, Missing); small intestine: 56.3725% (minimum 99%, Missing); smooth muscle: 56.0976% (minimum 99%, Missing); spinal cord: 59.8958% (minimum 99%, Missing); spleen: 53.7383% (minimum 90%, Approved); stomach: 50.6608% (minimum 97%, Missing); thymus: 56.3725% (minimum 95%, Missing); thyroid gland: 59.2784% (minimum 95%, Missing); tongue: 26.8692% (minimum 97%, Missing); urinary bladder: 52.0362% (minimum 97%, Missing)",-0.386275,-0.701308,-0.723796,0,4,partial,31.7,31.3,9.9,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 2); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 2); colon: 12.6 nTPM (protected, limit 2); cerebellum: 12.5 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 2); urinary bladder: 10.6 nTPM (protected, limit 2); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 2); parathyroid gland: 9.3 nTPM (protected, limit 4); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 8.8 nTPM (protected, limit 2); salivary gland: 8.7 nTPM (protected, limit 2); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thyroid gland: 7.9 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239789,MRPS17,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.2885% (minimum 60%, Approved); adrenal gland: 46.7480% (minimum 75%, Missing); amygdala: 46.5587% (minimum 75%, Missing); basal ganglia: 45.4545% (minimum 75%, Missing); bone marrow: 53.7383% (minimum 75%, Missing); cerebellum: 47.9167% (minimum 75%, Missing); cerebral cortex: 41.6667% (minimum 75%, Missing); choroid plexus: 60.5263% (minimum 75%, Missing); colon: 47.7178% (minimum 70%, Missing); duodenum: 57.2139% (minimum 75%, Missing); esophagus: 46.7480% (minimum 70%, Missing); heart muscle: 37.2168% (minimum 75%, Missing); hippocampal formation: 46.3710% (minimum 75%, Missing); hypothalamus: 47.9167% (minimum 75%, Missing); kidney: 41.3669% (minimum 75%, Missing); liver: 34.7432% (minimum 75%, Missing); lung: 63.1868% (minimum 75%, Missing); lymph node: 56.6502% (minimum 70%, Missing); midbrain: 54.2453% (minimum 75%, Missing); pancreas: 46.5587% (minimum 75%, Missing); parathyroid gland: 55.2885% (minimum 65%, Approved); pituitary gland: 58.6735% (minimum 75%, Missing); rectum: 54.7619% (minimum 70%, Missing); retina: 68.0473% (minimum 75%, Missing); salivary gland: 56.9307% (minimum 70%, Missing); skeletal muscle: 26.6204% (minimum 75%, Missing); skin: 58.9744% (minimum 65%, Missing); small intestine: 56.3725% (minimum 75%, Missing); smooth muscle: 56.0976% (minimum 75%, Missing); spinal cord: 59.8958% (minimum 75%, Missing); spleen: 53.7383% (minimum 60%, Approved); stomach: 50.6608% (minimum 70%, Missing); thymus: 56.3725% (minimum 65%, Missing); thyroid gland: 59.2784% (minimum 65%, Missing); tongue: 26.8692% (minimum 70%, Missing); urinary bladder: 52.0362% (minimum 70%, Missing)",-0.0862745,-0.431308,-0.483796,0,4,partial,31.7,31.3,9.9,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 2); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 2); colon: 12.6 nTPM (protected, limit 2); cerebellum: 12.5 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 2); urinary bladder: 10.6 nTPM (protected, limit 2); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 2); parathyroid gland: 9.3 nTPM (protected, limit 4); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 8.8 nTPM (protected, limit 2); salivary gland: 8.7 nTPM (protected, limit 2); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thyroid gland: 7.9 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239789,MRPS17,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.2885% (minimum 60%, Approved); adrenal gland: 46.7480% (minimum 75%, Missing); amygdala: 46.5587% (minimum 75%, Missing); basal ganglia: 45.4545% (minimum 75%, Missing); bone marrow: 53.7383% (minimum 75%, Missing); cerebellum: 47.9167% (minimum 75%, Missing); cerebral cortex: 41.6667% (minimum 75%, Missing); choroid plexus: 60.5263% (minimum 75%, Missing); colon: 47.7178% (minimum 70%, Missing); duodenum: 57.2139% (minimum 75%, Missing); esophagus: 46.7480% (minimum 70%, Missing); heart muscle: 37.2168% (minimum 75%, Missing); hippocampal formation: 46.3710% (minimum 75%, Missing); hypothalamus: 47.9167% (minimum 75%, Missing); kidney: 41.3669% (minimum 75%, Missing); liver: 34.7432% (minimum 75%, Missing); lung: 63.1868% (minimum 75%, Missing); lymph node: 56.6502% (minimum 70%, Missing); midbrain: 54.2453% (minimum 75%, Missing); pancreas: 46.5587% (minimum 75%, Missing); parathyroid gland: 55.2885% (minimum 65%, Approved); pituitary gland: 58.6735% (minimum 75%, Missing); rectum: 54.7619% (minimum 70%, Missing); retina: 68.0473% (minimum 75%, Missing); salivary gland: 56.9307% (minimum 70%, Missing); skeletal muscle: 26.6204% (minimum 75%, Missing); skin: 58.9744% (minimum 65%, Missing); small intestine: 56.3725% (minimum 75%, Missing); smooth muscle: 56.0976% (minimum 75%, Missing); spinal cord: 59.8958% (minimum 75%, Missing); spleen: 53.7383% (minimum 60%, Approved); stomach: 50.6608% (minimum 70%, Missing); thymus: 56.3725% (minimum 65%, Missing); thyroid gland: 59.2784% (minimum 65%, Missing); tongue: 26.8692% (minimum 70%, Missing); urinary bladder: 52.0362% (minimum 70%, Missing)",-0.0862745,-0.431308,-0.483796,0,4,partial,31.7,31.3,9.9,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 3); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 3); colon: 12.6 nTPM (protected, limit 3); cerebellum: 12.5 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 3); urinary bladder: 10.6 nTPM (protected, limit 3); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 3); parathyroid gland: 9.3 nTPM (protected, limit 4); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 8.8 nTPM (protected, limit 3); salivary gland: 8.7 nTPM (protected, limit 3); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thyroid gland: 7.9 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239789,MRPS17,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.2885% (minimum 60%, Approved); adrenal gland: 46.7480% (minimum 75%, Missing); amygdala: 46.5587% (minimum 75%, Missing); basal ganglia: 45.4545% (minimum 75%, Missing); bone marrow: 53.7383% (minimum 75%, Missing); cerebellum: 47.9167% (minimum 75%, Missing); cerebral cortex: 41.6667% (minimum 75%, Missing); choroid plexus: 60.5263% (minimum 75%, Missing); colon: 47.7178% (minimum 70%, Missing); duodenum: 57.2139% (minimum 75%, Missing); esophagus: 46.7480% (minimum 70%, Missing); heart muscle: 37.2168% (minimum 75%, Missing); hippocampal formation: 46.3710% (minimum 75%, Missing); hypothalamus: 47.9167% (minimum 75%, Missing); kidney: 41.3669% (minimum 75%, Missing); liver: 34.7432% (minimum 75%, Missing); lung: 63.1868% (minimum 75%, Missing); lymph node: 56.6502% (minimum 70%, Missing); midbrain: 54.2453% (minimum 75%, Missing); pancreas: 46.5587% (minimum 75%, Missing); parathyroid gland: 55.2885% (minimum 65%, Approved); pituitary gland: 58.6735% (minimum 75%, Missing); rectum: 54.7619% (minimum 70%, Missing); retina: 68.0473% (minimum 75%, Missing); salivary gland: 56.9307% (minimum 70%, Missing); skeletal muscle: 26.6204% (minimum 75%, Missing); skin: 58.9744% (minimum 65%, Missing); small intestine: 56.3725% (minimum 75%, Missing); smooth muscle: 56.0976% (minimum 75%, Missing); spinal cord: 59.8958% (minimum 75%, Missing); spleen: 53.7383% (minimum 60%, Approved); stomach: 50.6608% (minimum 70%, Missing); thymus: 56.3725% (minimum 65%, Missing); thyroid gland: 59.2784% (minimum 65%, Missing); tongue: 26.8692% (minimum 70%, Missing); urinary bladder: 52.0362% (minimum 70%, Missing)",-0.0862745,-0.431308,-0.483796,0,4,partial,31.7,31.3,9.9,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 3); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 3); colon: 12.6 nTPM (protected, limit 3); cerebellum: 12.5 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 3); urinary bladder: 10.6 nTPM (protected, limit 3); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 3); parathyroid gland: 9.3 nTPM (protected, limit 4); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 8.8 nTPM (protected, limit 3); salivary gland: 8.7 nTPM (protected, limit 3); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thyroid gland: 7.9 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239789,MRPS17,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.2885% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 46.7480% (minimum 75%, Baseline (adaptation disabled)); amygdala: 46.5587% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 45.4545% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 53.7383% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 47.9167% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 41.6667% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.5263% (minimum 75%, Baseline (adaptation disabled)); colon: 47.7178% (minimum 70%, Baseline (adaptation disabled)); duodenum: 57.2139% (minimum 75%, Baseline (adaptation disabled)); esophagus: 46.7480% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 37.2168% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 46.3710% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 47.9167% (minimum 75%, Baseline (adaptation disabled)); kidney: 41.3669% (minimum 75%, Baseline (adaptation disabled)); liver: 34.7432% (minimum 75%, Baseline (adaptation disabled)); lung: 63.1868% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.6502% (minimum 70%, Baseline (adaptation disabled)); midbrain: 54.2453% (minimum 75%, Baseline (adaptation disabled)); pancreas: 46.5587% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.2885% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 58.6735% (minimum 75%, Baseline (adaptation disabled)); rectum: 54.7619% (minimum 70%, Baseline (adaptation disabled)); retina: 68.0473% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 56.9307% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 26.6204% (minimum 75%, Baseline (adaptation disabled)); skin: 58.9744% (minimum 65%, Baseline (adaptation disabled)); small intestine: 56.3725% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.0976% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 59.8958% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.7383% (minimum 65%, Baseline (adaptation disabled)); stomach: 50.6608% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.3725% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 59.2784% (minimum 65%, Baseline (adaptation disabled)); tongue: 26.8692% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 52.0362% (minimum 70%, Baseline (adaptation disabled))",-0.112617,-0.431308,-0.483796,0,4,partial,31.7,31.3,9.9,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 3); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 3); colon: 12.6 nTPM (protected, limit 3); cerebellum: 12.5 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 3); urinary bladder: 10.6 nTPM (protected, limit 3); spleen: 9.9 nTPM (manageable, limit 5); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 3); parathyroid gland: 9.3 nTPM (protected, limit 3); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 8.8 nTPM (protected, limit 3); salivary gland: 8.7 nTPM (protected, limit 3); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thyroid gland: 7.9 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239789,MRPS17,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239810,PRAMEF11,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239810,PRAMEF11,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239810,PRAMEF11,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239810,PRAMEF11,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239810,PRAMEF11,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 0.3145% (minimum 95%, Missing)",-0.946855,0.03,0.01,0,80,unavailable,0,0,31.7,"skin: 31.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239886,KRTAP9-2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 0.3145% (minimum 65%, Missing)",-0.646855,0.3,0.25,0,80,unavailable,0,0,31.7,"skin: 31.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239886,KRTAP9-2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 0.3145% (minimum 65%, Missing)",-0.646855,0.3,0.25,0,80,unavailable,0,0,31.7,"skin: 31.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239886,KRTAP9-2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 0.3145% (minimum 65%, Missing)",-0.646855,0.3,0.25,0,80,unavailable,0,0,31.7,"skin: 31.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239886,KRTAP9-2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 0.3145% (minimum 65%, Baseline (adaptation disabled))",-0.646855,0.3,0.25,0,80,unavailable,0,0,31.7,"skin: 31.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239886,KRTAP9-2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.4433% (minimum 90%, Approved); adrenal gland: 45.9302% (minimum 99%, Missing); amygdala: 81.4433% (minimum 99%, Missing); basal ganglia: 82.2917% (minimum 99%, Missing); bone marrow: 79.7980% (minimum 99%, Missing); cerebellum: 54.8611% (minimum 99%, Missing); cerebral cortex: 76.6990% (minimum 99%, Missing); choroid plexus: 71.1712% (minimum 99%, Missing); colon: 46.7456% (minimum 97%, Missing); duodenum: 59.3985% (minimum 99%, Missing); esophagus: 66.3866% (minimum 97%, Missing); heart muscle: 70.5357% (minimum 99%, Missing); hippocampal formation: 75.2381% (minimum 99%, Missing); hypothalamus: 69.2982% (minimum 99%, Missing); kidney: 41.7989% (minimum 99%, Missing); liver: 26.9625% (minimum 99%, Missing); lung: 76.6990% (minimum 99%, Missing); lymph node: 96.3415% (minimum 97%, Missing); midbrain: 73.8318% (minimum 99%, Missing); pancreas: 69.2982% (minimum 99%, Missing); parathyroid gland: 66.9492% (minimum 97%, Missing); pituitary gland: 45.1429% (minimum 99%, Missing); rectum: 45.6647% (minimum 97%, Missing); retina: 53.7415% (minimum 99%, Missing); salivary gland: 48.7654% (minimum 97%, Missing); skeletal muscle: 92.9412% (minimum 99%, Missing); skin: 60.7692% (minimum 95%, Missing); small intestine: 50.6410% (minimum 99%, Missing); smooth muscle: 76.6990% (minimum 99%, Missing); spinal cord: 70.5357% (minimum 99%, Missing); spleen: 92.9412% (minimum 95%, Missing); stomach: 48.4663% (minimum 97%, Missing); thyroid gland: 91.8605% (minimum 95%, Missing); tongue: 92.9412% (minimum 97%, Missing); urinary bladder: 76.6990% (minimum 97%, Missing)",-0.342308,-0.513353,-0.720375,0,2,partial,21.4,9.4,5.1,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 2); stomach: 8.4 nTPM (protected, limit 2); salivary gland: 8.3 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); esophagus: 4 nTPM (protected, limit 2); parathyroid gland: 3.9 nTPM (protected, limit 2); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239887,C1orf226,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 45.9302% (minimum 75%, Missing); cerebellum: 54.8611% (minimum 75%, Missing); choroid plexus: 71.1712% (minimum 75%, Missing); colon: 46.7456% (minimum 70%, Missing); duodenum: 59.3985% (minimum 75%, Missing); esophagus: 66.3866% (minimum 70%, Missing); heart muscle: 70.5357% (minimum 75%, Missing); hypothalamus: 69.2982% (minimum 75%, Missing); kidney: 41.7989% (minimum 75%, Missing); liver: 26.9625% (minimum 75%, Missing); midbrain: 73.8318% (minimum 75%, Missing); pancreas: 69.2982% (minimum 75%, Missing); parathyroid gland: 66.9492% (minimum 70%, Missing); pituitary gland: 45.1429% (minimum 75%, Missing); rectum: 45.6647% (minimum 70%, Missing); retina: 53.7415% (minimum 75%, Missing); salivary gland: 48.7654% (minimum 70%, Missing); skin: 60.7692% (minimum 65%, Missing); small intestine: 50.6410% (minimum 75%, Missing); spinal cord: 70.5357% (minimum 75%, Missing); stomach: 48.4663% (minimum 70%, Missing)",-0.0423077,-0.243353,-0.480375,0,2,partial,21.4,9.4,5.1,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 2); stomach: 8.4 nTPM (protected, limit 2); salivary gland: 8.3 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); esophagus: 4 nTPM (protected, limit 2); parathyroid gland: 3.9 nTPM (protected, limit 2); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239887,C1orf226,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 45.9302% (minimum 75%, Missing); cerebellum: 54.8611% (minimum 75%, Missing); choroid plexus: 71.1712% (minimum 75%, Missing); colon: 46.7456% (minimum 70%, Missing); duodenum: 59.3985% (minimum 75%, Missing); esophagus: 66.3866% (minimum 70%, Missing); heart muscle: 70.5357% (minimum 75%, Missing); hypothalamus: 69.2982% (minimum 75%, Missing); kidney: 41.7989% (minimum 75%, Missing); liver: 26.9625% (minimum 75%, Missing); midbrain: 73.8318% (minimum 75%, Missing); pancreas: 69.2982% (minimum 75%, Missing); parathyroid gland: 66.9492% (minimum 70%, Missing); pituitary gland: 45.1429% (minimum 75%, Missing); rectum: 45.6647% (minimum 70%, Missing); retina: 53.7415% (minimum 75%, Missing); salivary gland: 48.7654% (minimum 70%, Missing); skin: 60.7692% (minimum 65%, Missing); small intestine: 50.6410% (minimum 75%, Missing); spinal cord: 70.5357% (minimum 75%, Missing); stomach: 48.4663% (minimum 70%, Missing)",-0.0423077,-0.243353,-0.480375,0,2,partial,21.4,9.4,5.1,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 3); stomach: 8.4 nTPM (protected, limit 3); salivary gland: 8.3 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); esophagus: 4 nTPM (protected, limit 3); parathyroid gland: 3.9 nTPM (protected, limit 3); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239887,C1orf226,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 45.9302% (minimum 75%, Missing); cerebellum: 54.8611% (minimum 75%, Missing); choroid plexus: 71.1712% (minimum 75%, Missing); colon: 46.7456% (minimum 70%, Missing); duodenum: 59.3985% (minimum 75%, Missing); esophagus: 66.3866% (minimum 70%, Missing); heart muscle: 70.5357% (minimum 75%, Missing); hypothalamus: 69.2982% (minimum 75%, Missing); kidney: 41.7989% (minimum 75%, Missing); liver: 26.9625% (minimum 75%, Missing); midbrain: 73.8318% (minimum 75%, Missing); pancreas: 69.2982% (minimum 75%, Missing); parathyroid gland: 66.9492% (minimum 70%, Missing); pituitary gland: 45.1429% (minimum 75%, Missing); rectum: 45.6647% (minimum 70%, Missing); retina: 53.7415% (minimum 75%, Missing); salivary gland: 48.7654% (minimum 70%, Missing); skin: 60.7692% (minimum 65%, Missing); small intestine: 50.6410% (minimum 75%, Missing); spinal cord: 70.5357% (minimum 75%, Missing); stomach: 48.4663% (minimum 70%, Missing)",-0.0423077,-0.243353,-0.480375,0,2,partial,21.4,9.4,5.1,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 3); stomach: 8.4 nTPM (protected, limit 3); salivary gland: 8.3 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); esophagus: 4 nTPM (protected, limit 3); parathyroid gland: 3.9 nTPM (protected, limit 3); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239887,C1orf226,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 45.9302% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.8611% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 71.1712% (minimum 75%, Baseline (adaptation disabled)); colon: 46.7456% (minimum 70%, Baseline (adaptation disabled)); duodenum: 59.3985% (minimum 75%, Baseline (adaptation disabled)); esophagus: 66.3866% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.5357% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.2982% (minimum 75%, Baseline (adaptation disabled)); kidney: 41.7989% (minimum 75%, Baseline (adaptation disabled)); liver: 26.9625% (minimum 75%, Baseline (adaptation disabled)); midbrain: 73.8318% (minimum 75%, Baseline (adaptation disabled)); pancreas: 69.2982% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.9492% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 45.1429% (minimum 75%, Baseline (adaptation disabled)); rectum: 45.6647% (minimum 70%, Baseline (adaptation disabled)); retina: 53.7415% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 48.7654% (minimum 70%, Baseline (adaptation disabled)); skin: 60.7692% (minimum 65%, Baseline (adaptation disabled)); small intestine: 50.6410% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.5357% (minimum 75%, Baseline (adaptation disabled)); stomach: 48.4663% (minimum 70%, Baseline (adaptation disabled))",-0.0423077,-0.243353,-0.480375,0,2,partial,21.4,9.4,5.1,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 3); stomach: 8.4 nTPM (protected, limit 3); salivary gland: 8.3 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); esophagus: 4 nTPM (protected, limit 3); parathyroid gland: 3.9 nTPM (protected, limit 3); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000239887,C1orf226,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.7091% (minimum 99%, Missing)",0.0482594,0.0273913,-0.00290878,0,3,partial,1.8,1.4,1.5,"retina: 1.5 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240021,TEX35,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348259,0.297391,0.237091,0,3,partial,1.8,1.4,1.5,"retina: 1.5 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240021,TEX35,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348259,0.297391,0.237091,0,3,partial,1.8,1.4,1.5,"retina: 1.5 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240021,TEX35,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348259,0.297391,0.237091,0,3,partial,1.8,1.4,1.5,"retina: 1.5 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240021,TEX35,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.337091,0.287941,0.234549,0,3,partial,1.8,1.4,1.5,"bone marrow: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240021,TEX35,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.0032% (minimum 99%, Missing); basal ganglia: 92.3136% (minimum 99%, Missing); cerebellum: 98.6853% (minimum 99%, Missing); cerebral cortex: 94.7908% (minimum 99%, Missing); choroid plexus: 98.9292% (minimum 99%, Missing); hippocampal formation: 96.0800% (minimum 99%, Missing); hypothalamus: 96.2340% (minimum 99%, Missing); midbrain: 98.2011% (minimum 99%, Missing); pancreas: 98.2011% (minimum 99%, Missing); parathyroid gland: 95.0911% (minimum 97%, Missing); pituitary gland: 95.3175% (minimum 99%, Missing)",0.0442053,-0.0190895,-0.066864,0,80,unavailable,10,6.2,0.7,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 2); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240204,SMKR1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344205,0.250911,0.173136,0,80,unavailable,10,6.2,0.7,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 2); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240204,SMKR1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344205,0.250911,0.173136,0,80,unavailable,10,6.2,0.7,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 3); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240204,SMKR1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344205,0.250911,0.173136,0,80,unavailable,10,6.2,0.7,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 3); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240204,SMKR1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344205,0.250911,0.173136,0,80,unavailable,10,6.2,0.7,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 3); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240204,SMKR1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 38.0952% (minimum 60%, Enhanced); adrenal gland: 56.4706% (minimum 95%, Enhanced); amygdala: 73.2824% (minimum 99%, Missing); basal ganglia: 69.5652% (minimum 99%, Missing); bone marrow: 55.4913% (minimum 95%, Enhanced); cerebellum: 69.5652% (minimum 99%, Missing); cerebral cortex: 70.0730% (minimum 99%, Missing); choroid plexus: 17.2043% (minimum 99%, Missing); colon: 56.4706% (minimum 97%, Missing); duodenum: 36.6412% (minimum 99%, Missing); esophagus: 71.1111% (minimum 80%, Enhanced); heart muscle: 39.1837% (minimum 99%, Missing); hippocampal formation: 73.2824% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 13.3891% (minimum 99%, Missing); liver: 8.7193% (minimum 99%, Missing); lung: 63.1579% (minimum 95%, Enhanced); lymph node: 75.0000% (minimum 80%, Enhanced); midbrain: 70.5882% (minimum 99%, Missing); pancreas: 54.8571% (minimum 95%, Enhanced); parathyroid gland: 52.7473% (minimum 80%, Enhanced); pituitary gland: 50.2618% (minimum 99%, Missing); rectum: 74.4186% (minimum 97%, Missing); retina: 45.9330% (minimum 99%, Missing); salivary gland: 63.5762% (minimum 80%, Enhanced); skeletal muscle: 70.0730% (minimum 99%, Missing); small intestine: 38.5542% (minimum 99%, Missing); smooth muscle: 61.1465% (minimum 95%, Enhanced); spinal cord: 67.1329% (minimum 99%, Missing); stomach: 67.6056% (minimum 97%, Missing); thymus: 68.0851% (minimum 95%, Missing); tongue: 83.4783% (minimum 97%, Missing); urinary bladder: 64.4295% (minimum 80%, Enhanced)",-0.269149,-0.405294,-0.902807,0,12,partial,100.5,8.6,15.6,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 6); bone marrow: 7.7 nTPM (vital, limit 6); adrenal gland: 7.4 nTPM (vital, limit 6); colon: 7.4 nTPM (protected, limit 2); smooth muscle: 6.1 nTPM (vital, limit 6); spinal cord: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); hypothalamus: 3.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),93,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240303,ACAD11,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 38.0952% (minimum 50%, Enhanced); adrenal gland: 56.4706% (minimum 60%, Enhanced); amygdala: 73.2824% (minimum 75%, Missing); basal ganglia: 69.5652% (minimum 75%, Missing); bone marrow: 55.4913% (minimum 60%, Enhanced); cerebellum: 69.5652% (minimum 75%, Missing); cerebral cortex: 70.0730% (minimum 75%, Missing); choroid plexus: 17.2043% (minimum 75%, Missing); colon: 56.4706% (minimum 70%, Missing); duodenum: 36.6412% (minimum 75%, Missing); heart muscle: 39.1837% (minimum 75%, Missing); hippocampal formation: 73.2824% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); kidney: 13.3891% (minimum 75%, Missing); liver: 8.7193% (minimum 75%, Missing); midbrain: 70.5882% (minimum 75%, Missing); pancreas: 54.8571% (minimum 60%, Enhanced); parathyroid gland: 52.7473% (minimum 55%, Enhanced); pituitary gland: 50.2618% (minimum 75%, Missing); retina: 45.9330% (minimum 75%, Missing); skeletal muscle: 70.0730% (minimum 75%, Missing); small intestine: 38.5542% (minimum 75%, Missing); spinal cord: 67.1329% (minimum 75%, Missing); stomach: 67.6056% (minimum 70%, Missing)",-0.119048,-0.135294,-0.662807,0,12,partial,100.5,8.6,15.6,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 6); bone marrow: 7.7 nTPM (vital, limit 6); adrenal gland: 7.4 nTPM (vital, limit 6); colon: 7.4 nTPM (protected, limit 2); smooth muscle: 6.1 nTPM (vital, limit 6); spinal cord: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); hypothalamus: 3.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),93,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240303,ACAD11,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 38.0952% (minimum 50%, Enhanced); adrenal gland: 56.4706% (minimum 60%, Enhanced); amygdala: 73.2824% (minimum 75%, Missing); basal ganglia: 69.5652% (minimum 75%, Missing); bone marrow: 55.4913% (minimum 60%, Enhanced); cerebellum: 69.5652% (minimum 75%, Missing); cerebral cortex: 70.0730% (minimum 75%, Missing); choroid plexus: 17.2043% (minimum 75%, Missing); colon: 56.4706% (minimum 70%, Missing); duodenum: 36.6412% (minimum 75%, Missing); heart muscle: 39.1837% (minimum 75%, Missing); hippocampal formation: 73.2824% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); kidney: 13.3891% (minimum 75%, Missing); liver: 8.7193% (minimum 75%, Missing); midbrain: 70.5882% (minimum 75%, Missing); pancreas: 54.8571% (minimum 60%, Enhanced); parathyroid gland: 52.7473% (minimum 55%, Enhanced); pituitary gland: 50.2618% (minimum 75%, Missing); retina: 45.9330% (minimum 75%, Missing); skeletal muscle: 70.0730% (minimum 75%, Missing); small intestine: 38.5542% (minimum 75%, Missing); spinal cord: 67.1329% (minimum 75%, Missing); stomach: 67.6056% (minimum 70%, Missing)",-0.119048,-0.135294,-0.662807,0,12,partial,100.5,8.6,15.6,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 6); bone marrow: 7.7 nTPM (vital, limit 6); adrenal gland: 7.4 nTPM (vital, limit 6); colon: 7.4 nTPM (protected, limit 3); smooth muscle: 6.1 nTPM (vital, limit 6); spinal cord: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 3); hypothalamus: 3.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),93,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240303,ACAD11,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 38.0952% (minimum 50%, Enhanced); adrenal gland: 56.4706% (minimum 60%, Enhanced); amygdala: 73.2824% (minimum 75%, Missing); basal ganglia: 69.5652% (minimum 75%, Missing); bone marrow: 55.4913% (minimum 60%, Enhanced); cerebellum: 69.5652% (minimum 75%, Missing); cerebral cortex: 70.0730% (minimum 75%, Missing); choroid plexus: 17.2043% (minimum 75%, Missing); colon: 56.4706% (minimum 70%, Missing); duodenum: 36.6412% (minimum 75%, Missing); heart muscle: 39.1837% (minimum 75%, Missing); hippocampal formation: 73.2824% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); kidney: 13.3891% (minimum 75%, Missing); liver: 8.7193% (minimum 75%, Missing); midbrain: 70.5882% (minimum 75%, Missing); pancreas: 54.8571% (minimum 60%, Enhanced); parathyroid gland: 52.7473% (minimum 55%, Enhanced); pituitary gland: 50.2618% (minimum 75%, Missing); retina: 45.9330% (minimum 75%, Missing); skeletal muscle: 70.0730% (minimum 75%, Missing); small intestine: 38.5542% (minimum 75%, Missing); spinal cord: 67.1329% (minimum 75%, Missing); stomach: 67.6056% (minimum 70%, Missing)",-0.119048,-0.135294,-0.662807,0,12,partial,100.5,8.6,15.6,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 6); bone marrow: 7.7 nTPM (vital, limit 6); adrenal gland: 7.4 nTPM (vital, limit 6); colon: 7.4 nTPM (protected, limit 3); smooth muscle: 6.1 nTPM (vital, limit 6); spinal cord: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 3); hypothalamus: 3.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),93,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240303,ACAD11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 38.0952% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 56.4706% (minimum 75%, Baseline (adaptation disabled)); amygdala: 73.2824% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 69.5652% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 55.4913% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 69.5652% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 70.0730% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 17.2043% (minimum 75%, Baseline (adaptation disabled)); colon: 56.4706% (minimum 70%, Baseline (adaptation disabled)); duodenum: 36.6412% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 39.1837% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 73.2824% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 13.3891% (minimum 75%, Baseline (adaptation disabled)); liver: 8.7193% (minimum 75%, Baseline (adaptation disabled)); lung: 63.1579% (minimum 75%, Baseline (adaptation disabled)); midbrain: 70.5882% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.8571% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.7473% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 50.2618% (minimum 75%, Baseline (adaptation disabled)); retina: 45.9330% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.5762% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 70.0730% (minimum 75%, Baseline (adaptation disabled)); skin: 61.1465% (minimum 65%, Baseline (adaptation disabled)); small intestine: 38.5542% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.1465% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.1329% (minimum 75%, Baseline (adaptation disabled)); stomach: 67.6056% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 60.7595% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 64.4295% (minimum 70%, Baseline (adaptation disabled))",-0.269048,-0.172527,-0.662807,0,12,partial,100.5,8.6,15.6,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); adipose tissue: 15.6 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); parathyroid gland: 8.6 nTPM (protected, limit 3); pancreas: 7.9 nTPM (vital, limit 1); bone marrow: 7.7 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 3); adrenal gland: 7.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6.1 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); urinary bladder: 5.3 nTPM (protected, limit 3); spinal cord: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 3); lymph node: 3.2 nTPM (protected, limit 3); hypothalamus: 3.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),93,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240303,ACAD11,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Missing); adrenal gland: 80.3571% (minimum 99%, Missing); bone marrow: 81.8182% (minimum 99%, Missing); cerebral cortex: 67.1642% (minimum 99%, Missing); choroid plexus: 86.5385% (minimum 99%, Missing); colon: 81.8182% (minimum 97%, Missing); duodenum: 83.3333% (minimum 99%, Missing); esophagus: 78.9474% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 93.7500% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 72.5806% (minimum 97%, Missing); pancreas: 84.9057% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); rectum: 84.9057% (minimum 97%, Missing); retina: 72.5806% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 80.3571% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 93.7500% (minimum 99%, Missing); smooth muscle: 73.7705% (minimum 99%, Missing); spleen: 80.3571% (minimum 95%, Missing); stomach: 81.8182% (minimum 97%, Missing); thymus: 66.1765% (minimum 95%, Missing); thyroid gland: 81.8182% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 83.3333% (minimum 97%, Missing)",-0.288235,-0.244194,-0.318358,9,80,unavailable,2.2,1.7,2.3,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240445,FOXO3B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"cerebral cortex: 67.1642% (minimum 75%, Missing); retina: 72.5806% (minimum 75%, Missing); smooth muscle: 73.7705% (minimum 75%, Missing)",0.0117647,0.0258065,-0.0783582,9,80,unavailable,2.2,1.7,2.3,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240445,FOXO3B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"cerebral cortex: 67.1642% (minimum 75%, Missing); retina: 72.5806% (minimum 75%, Missing); smooth muscle: 73.7705% (minimum 75%, Missing)",0.0117647,0.0258065,-0.0783582,9,80,unavailable,2.2,1.7,2.3,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240445,FOXO3B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"cerebral cortex: 67.1642% (minimum 75%, Missing); retina: 72.5806% (minimum 75%, Missing); smooth muscle: 73.7705% (minimum 75%, Missing)",0.0117647,0.0258065,-0.0783582,9,80,unavailable,2.2,1.7,2.3,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240445,FOXO3B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"cerebral cortex: 67.1642% (minimum 75%, Baseline (adaptation disabled)); retina: 72.5806% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.7705% (minimum 75%, Baseline (adaptation disabled))",0.0117647,0.0258065,-0.0783582,9,80,unavailable,2.2,1.7,2.3,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240445,FOXO3B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.3913% (minimum 99%, Missing); colon: 68.2927% (minimum 97%, Missing); kidney: 97.3913% (minimum 99%, Missing); lung: 88.8889% (minimum 99%, Missing); rectum: 90.3226% (minimum 97%, Missing); salivary gland: 96.5517% (minimum 97%, Missing); small intestine: 97.3913% (minimum 99%, Missing); smooth muscle: 97.3913% (minimum 99%, Missing); spleen: 92.5620% (minimum 95%, Missing)",-0.0243802,-0.287073,-0.101111,0,80,unavailable,1.4,5.2,0.9,"colon: 5.2 nTPM (protected, limit 2); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240563,L1TD1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 68.2927% (minimum 70%, Missing)",0.27562,-0.0170732,0.138889,0,80,unavailable,1.4,5.2,0.9,"colon: 5.2 nTPM (protected, limit 2); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240563,L1TD1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 68.2927% (minimum 70%, Missing)",0.27562,-0.0170732,0.138889,0,80,unavailable,1.4,5.2,0.9,"colon: 5.2 nTPM (protected, limit 3); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240563,L1TD1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 68.2927% (minimum 70%, Missing)",0.27562,-0.0170732,0.138889,0,80,unavailable,1.4,5.2,0.9,"colon: 5.2 nTPM (protected, limit 3); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240563,L1TD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 68.2927% (minimum 70%, Baseline (adaptation disabled))",0.27562,-0.0170732,0.138889,0,80,unavailable,1.4,5.2,0.9,"colon: 5.2 nTPM (protected, limit 3); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240563,L1TD1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0609% (minimum 95%, Missing); adrenal gland: 61.5607% (minimum 99%, Missing); amygdala: 67.1924% (minimum 99%, Missing); basal ganglia: 66.5625% (minimum 99%, Missing); bone marrow: 29.7071% (minimum 99%, Missing); cerebellum: 64.7416% (minimum 99%, Missing); cerebral cortex: 62.4633% (minimum 99%, Missing); choroid plexus: 67.4051% (minimum 99%, Missing); colon: 50.4739% (minimum 97%, Missing); duodenum: 58.8398% (minimum 99%, Missing); esophagus: 49.7664% (minimum 97%, Missing); heart muscle: 50.8353% (minimum 99%, Missing); hippocampal formation: 68.2692% (minimum 99%, Missing); hypothalamus: 67.8344% (minimum 99%, Missing); kidney: 59.3315% (minimum 99%, Missing); liver: 66.7712% (minimum 99%, Missing); lung: 60.8571% (minimum 99%, Missing); lymph node: 40.5714% (minimum 97%, Missing); midbrain: 66.9811% (minimum 99%, Missing); pancreas: 58.1967% (minimum 99%, Missing); parathyroid gland: 66.3551% (minimum 97%, Missing); pituitary gland: 71.4765% (minimum 99%, Missing); rectum: 56.6489% (minimum 97%, Missing); retina: 67.8344% (minimum 99%, Missing); salivary gland: 59.6639% (minimum 97%, Missing); skeletal muscle: 38.7978% (minimum 99%, Missing); skin: 51.9512% (minimum 95%, Missing); small intestine: 57.5676% (minimum 99%, Missing); smooth muscle: 52.2059% (minimum 99%, Missing); spinal cord: 66.3551% (minimum 99%, Missing); spleen: 54.4757% (minimum 95%, Missing); stomach: 59.6639% (minimum 97%, Missing); thymus: 49.0783% (minimum 95%, Missing); thyroid gland: 59.6639% (minimum 95%, Missing); tongue: 51.0791% (minimum 97%, Missing); urinary bladder: 54.6154% (minimum 97%, Missing)",-0.459217,-0.564286,-0.692929,0,4,partial,50.4,31.2,22.1,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 2); thymus: 22.1 nTPM (manageable, limit 5); esophagus: 21.5 nTPM (protected, limit 2); colon: 20.9 nTPM (protected, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 2); skin: 19.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); adipose tissue: 18.1 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); urinary bladder: 17.7 nTPM (protected, limit 2); rectum: 16.3 nTPM (protected, limit 2); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); salivary gland: 14.4 nTPM (protected, limit 2); thyroid gland: 14.4 nTPM (manageable, limit 5); stomach: 14.4 nTPM (protected, limit 2); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240682,ISY1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0609% (minimum 65%, Missing); adrenal gland: 61.5607% (minimum 75%, Missing); amygdala: 67.1924% (minimum 75%, Missing); basal ganglia: 66.5625% (minimum 75%, Missing); bone marrow: 29.7071% (minimum 75%, Missing); cerebellum: 64.7416% (minimum 75%, Missing); cerebral cortex: 62.4633% (minimum 75%, Missing); choroid plexus: 67.4051% (minimum 75%, Missing); colon: 50.4739% (minimum 70%, Missing); duodenum: 58.8398% (minimum 75%, Missing); esophagus: 49.7664% (minimum 70%, Missing); heart muscle: 50.8353% (minimum 75%, Missing); hippocampal formation: 68.2692% (minimum 75%, Missing); hypothalamus: 67.8344% (minimum 75%, Missing); kidney: 59.3315% (minimum 75%, Missing); liver: 66.7712% (minimum 75%, Missing); lung: 60.8571% (minimum 75%, Missing); lymph node: 40.5714% (minimum 70%, Missing); midbrain: 66.9811% (minimum 75%, Missing); pancreas: 58.1967% (minimum 75%, Missing); parathyroid gland: 66.3551% (minimum 70%, Missing); pituitary gland: 71.4765% (minimum 75%, Missing); rectum: 56.6489% (minimum 70%, Missing); retina: 67.8344% (minimum 75%, Missing); salivary gland: 59.6639% (minimum 70%, Missing); skeletal muscle: 38.7978% (minimum 75%, Missing); skin: 51.9512% (minimum 65%, Missing); small intestine: 57.5676% (minimum 75%, Missing); smooth muscle: 52.2059% (minimum 75%, Missing); spinal cord: 66.3551% (minimum 75%, Missing); spleen: 54.4757% (minimum 65%, Missing); stomach: 59.6639% (minimum 70%, Missing); thymus: 49.0783% (minimum 65%, Missing); thyroid gland: 59.6639% (minimum 65%, Missing); tongue: 51.0791% (minimum 70%, Missing); urinary bladder: 54.6154% (minimum 70%, Missing)",-0.159217,-0.294286,-0.452929,0,4,partial,50.4,31.2,22.1,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 2); thymus: 22.1 nTPM (manageable, limit 5); esophagus: 21.5 nTPM (protected, limit 2); colon: 20.9 nTPM (protected, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 2); skin: 19.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); adipose tissue: 18.1 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); urinary bladder: 17.7 nTPM (protected, limit 2); rectum: 16.3 nTPM (protected, limit 2); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); salivary gland: 14.4 nTPM (protected, limit 2); thyroid gland: 14.4 nTPM (manageable, limit 5); stomach: 14.4 nTPM (protected, limit 2); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240682,ISY1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0609% (minimum 65%, Missing); adrenal gland: 61.5607% (minimum 75%, Missing); amygdala: 67.1924% (minimum 75%, Missing); basal ganglia: 66.5625% (minimum 75%, Missing); bone marrow: 29.7071% (minimum 75%, Missing); cerebellum: 64.7416% (minimum 75%, Missing); cerebral cortex: 62.4633% (minimum 75%, Missing); choroid plexus: 67.4051% (minimum 75%, Missing); colon: 50.4739% (minimum 70%, Missing); duodenum: 58.8398% (minimum 75%, Missing); esophagus: 49.7664% (minimum 70%, Missing); heart muscle: 50.8353% (minimum 75%, Missing); hippocampal formation: 68.2692% (minimum 75%, Missing); hypothalamus: 67.8344% (minimum 75%, Missing); kidney: 59.3315% (minimum 75%, Missing); liver: 66.7712% (minimum 75%, Missing); lung: 60.8571% (minimum 75%, Missing); lymph node: 40.5714% (minimum 70%, Missing); midbrain: 66.9811% (minimum 75%, Missing); pancreas: 58.1967% (minimum 75%, Missing); parathyroid gland: 66.3551% (minimum 70%, Missing); pituitary gland: 71.4765% (minimum 75%, Missing); rectum: 56.6489% (minimum 70%, Missing); retina: 67.8344% (minimum 75%, Missing); salivary gland: 59.6639% (minimum 70%, Missing); skeletal muscle: 38.7978% (minimum 75%, Missing); skin: 51.9512% (minimum 65%, Missing); small intestine: 57.5676% (minimum 75%, Missing); smooth muscle: 52.2059% (minimum 75%, Missing); spinal cord: 66.3551% (minimum 75%, Missing); spleen: 54.4757% (minimum 65%, Missing); stomach: 59.6639% (minimum 70%, Missing); thymus: 49.0783% (minimum 65%, Missing); thyroid gland: 59.6639% (minimum 65%, Missing); tongue: 51.0791% (minimum 70%, Missing); urinary bladder: 54.6154% (minimum 70%, Missing)",-0.159217,-0.294286,-0.452929,0,4,partial,50.4,31.2,22.1,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 3); thymus: 22.1 nTPM (manageable, limit 5); esophagus: 21.5 nTPM (protected, limit 3); colon: 20.9 nTPM (protected, limit 3); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 3); skin: 19.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); adipose tissue: 18.1 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); urinary bladder: 17.7 nTPM (protected, limit 3); rectum: 16.3 nTPM (protected, limit 3); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); salivary gland: 14.4 nTPM (protected, limit 3); thyroid gland: 14.4 nTPM (manageable, limit 5); stomach: 14.4 nTPM (protected, limit 3); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 3); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240682,ISY1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0609% (minimum 65%, Missing); adrenal gland: 61.5607% (minimum 75%, Missing); amygdala: 67.1924% (minimum 75%, Missing); basal ganglia: 66.5625% (minimum 75%, Missing); bone marrow: 29.7071% (minimum 75%, Missing); cerebellum: 64.7416% (minimum 75%, Missing); cerebral cortex: 62.4633% (minimum 75%, Missing); choroid plexus: 67.4051% (minimum 75%, Missing); colon: 50.4739% (minimum 70%, Missing); duodenum: 58.8398% (minimum 75%, Missing); esophagus: 49.7664% (minimum 70%, Missing); heart muscle: 50.8353% (minimum 75%, Missing); hippocampal formation: 68.2692% (minimum 75%, Missing); hypothalamus: 67.8344% (minimum 75%, Missing); kidney: 59.3315% (minimum 75%, Missing); liver: 66.7712% (minimum 75%, Missing); lung: 60.8571% (minimum 75%, Missing); lymph node: 40.5714% (minimum 70%, Missing); midbrain: 66.9811% (minimum 75%, Missing); pancreas: 58.1967% (minimum 75%, Missing); parathyroid gland: 66.3551% (minimum 70%, Missing); pituitary gland: 71.4765% (minimum 75%, Missing); rectum: 56.6489% (minimum 70%, Missing); retina: 67.8344% (minimum 75%, Missing); salivary gland: 59.6639% (minimum 70%, Missing); skeletal muscle: 38.7978% (minimum 75%, Missing); skin: 51.9512% (minimum 65%, Missing); small intestine: 57.5676% (minimum 75%, Missing); smooth muscle: 52.2059% (minimum 75%, Missing); spinal cord: 66.3551% (minimum 75%, Missing); spleen: 54.4757% (minimum 65%, Missing); stomach: 59.6639% (minimum 70%, Missing); thymus: 49.0783% (minimum 65%, Missing); thyroid gland: 59.6639% (minimum 65%, Missing); tongue: 51.0791% (minimum 70%, Missing); urinary bladder: 54.6154% (minimum 70%, Missing)",-0.159217,-0.294286,-0.452929,0,4,partial,50.4,31.2,22.1,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 3); thymus: 22.1 nTPM (manageable, limit 5); esophagus: 21.5 nTPM (protected, limit 3); colon: 20.9 nTPM (protected, limit 3); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 3); skin: 19.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); adipose tissue: 18.1 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); urinary bladder: 17.7 nTPM (protected, limit 3); rectum: 16.3 nTPM (protected, limit 3); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); salivary gland: 14.4 nTPM (protected, limit 3); thyroid gland: 14.4 nTPM (manageable, limit 5); stomach: 14.4 nTPM (protected, limit 3); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 3); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240682,ISY1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0609% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 61.5607% (minimum 75%, Baseline (adaptation disabled)); amygdala: 67.1924% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 66.5625% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 29.7071% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 64.7416% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 62.4633% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 67.4051% (minimum 75%, Baseline (adaptation disabled)); colon: 50.4739% (minimum 70%, Baseline (adaptation disabled)); duodenum: 58.8398% (minimum 75%, Baseline (adaptation disabled)); esophagus: 49.7664% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 50.8353% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 68.2692% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.8344% (minimum 75%, Baseline (adaptation disabled)); kidney: 59.3315% (minimum 75%, Baseline (adaptation disabled)); liver: 66.7712% (minimum 75%, Baseline (adaptation disabled)); lung: 60.8571% (minimum 75%, Baseline (adaptation disabled)); lymph node: 40.5714% (minimum 70%, Baseline (adaptation disabled)); midbrain: 66.9811% (minimum 75%, Baseline (adaptation disabled)); pancreas: 58.1967% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 66.3551% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 71.4765% (minimum 75%, Baseline (adaptation disabled)); rectum: 56.6489% (minimum 70%, Baseline (adaptation disabled)); retina: 67.8344% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 59.6639% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 38.7978% (minimum 75%, Baseline (adaptation disabled)); skin: 51.9512% (minimum 65%, Baseline (adaptation disabled)); small intestine: 57.5676% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 52.2059% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 66.3551% (minimum 75%, Baseline (adaptation disabled)); spleen: 54.4757% (minimum 65%, Baseline (adaptation disabled)); stomach: 59.6639% (minimum 70%, Baseline (adaptation disabled)); thymus: 49.0783% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 59.6639% (minimum 65%, Baseline (adaptation disabled)); tongue: 51.0791% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 54.6154% (minimum 70%, Baseline (adaptation disabled))",-0.159217,-0.294286,-0.452929,0,4,partial,50.4,31.2,22.1,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 3); thymus: 22.1 nTPM (manageable, limit 5); esophagus: 21.5 nTPM (protected, limit 3); colon: 20.9 nTPM (protected, limit 3); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 3); skin: 19.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); adipose tissue: 18.1 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); urinary bladder: 17.7 nTPM (protected, limit 3); rectum: 16.3 nTPM (protected, limit 3); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); salivary gland: 14.4 nTPM (protected, limit 3); thyroid gland: 14.4 nTPM (manageable, limit 5); stomach: 14.4 nTPM (protected, limit 3); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 3); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240682,ISY1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 97.2789% (minimum 99%, Missing)",0.05,0.03,-0.0172109,0,4,partial,0.4,0.1,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240720,LRRD1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.222789,0,4,partial,0.4,0.1,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240720,LRRD1,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.222789,0,4,partial,0.4,0.1,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240720,LRRD1,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.222789,0,4,partial,0.4,0.1,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240720,LRRD1,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.329452,0.293056,0.222789,0,4,partial,0.4,0.1,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240720,LRRD1,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7111% (minimum 99%, Missing); amygdala: 98.0102% (minimum 99%, Missing); basal ganglia: 98.3615% (minimum 99%, Missing); cerebellum: 98.8677% (minimum 99%, Missing); cerebral cortex: 98.3615% (minimum 99%, Missing); choroid plexus: 98.8169% (minimum 99%, Missing); heart muscle: 98.1604% (minimum 99%, Missing); hippocampal formation: 98.3112% (minimum 99%, Missing); hypothalamus: 98.3615% (minimum 99%, Missing); kidney: 97.3151% (minimum 99%, Missing); midbrain: 98.2106% (minimum 99%, Missing); pancreas: 98.0102% (minimum 99%, Missing); pituitary gland: 98.1604% (minimum 99%, Missing); retina: 98.6140% (minimum 99%, Missing); smooth muscle: 97.3644% (minimum 99%, Missing); spinal cord: 97.6614% (minimum 99%, Missing)",0.0241379,0.00661413,-0.016849,0,80,unavailable,5.3,4.6,5.1,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); esophagus: 4.6 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240747,KRBOX1,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.324138,0.276614,0.223151,0,80,unavailable,5.3,4.6,5.1,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); esophagus: 4.6 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240747,KRBOX1,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.324138,0.276614,0.223151,0,80,unavailable,5.3,4.6,5.1,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); esophagus: 4.6 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3); adrenal gland: 4.5 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240747,KRBOX1,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.324138,0.276614,0.223151,0,80,unavailable,5.3,4.6,5.1,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); esophagus: 4.6 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3); adrenal gland: 4.5 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240747,KRBOX1,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.324138,0.276614,0.223151,0,80,unavailable,5.3,4.6,5.1,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); esophagus: 4.6 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3); adrenal gland: 4.5 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000240747,KRBOX1,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000241128,OR14A2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000241128,OR14A2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000241128,OR14A2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000241128,OR14A2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000241128,OR14A2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 94.4444% (minimum 99%, Missing)",0.05,0.03,-0.0455556,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241149,ZNF722,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.194444,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241149,ZNF722,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.194444,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241149,ZNF722,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.194444,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241149,ZNF722,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.194444,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241149,ZNF722,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Missing); adrenal gland: 93.3333% (minimum 99%, Missing); amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 73.6842% (minimum 99%, Missing); cerebellum: 82.3529% (minimum 99%, Missing); cerebral cortex: 73.6842% (minimum 99%, Missing); colon: 93.3333% (minimum 97%, Missing); esophagus: 93.3333% (minimum 97%, Missing); hippocampal formation: 82.3529% (minimum 99%, Missing); hypothalamus: 77.7778% (minimum 99%, Missing); kidney: 19.4444% (minimum 99%, Missing); liver: 87.5000% (minimum 99%, Missing); lung: 93.3333% (minimum 99%, Missing); midbrain: 87.5000% (minimum 99%, Missing); pancreas: 93.3333% (minimum 99%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); salivary gland: 93.3333% (minimum 97%, Missing); skeletal muscle: 93.3333% (minimum 99%, Missing); skin: 16.0920% (minimum 95%, Missing); small intestine: 93.3333% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Missing); urinary bladder: 73.6842% (minimum 97%, Missing)",-0.78908,-0.233158,-0.795556,0,80,unavailable,5.8,0.5,7.3,"skin: 7.3 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241233,KRTAP5-8,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 73.6842% (minimum 75%, Missing); cerebral cortex: 73.6842% (minimum 75%, Missing); kidney: 19.4444% (minimum 75%, Missing); skin: 16.0920% (minimum 65%, Missing)",-0.48908,0.0368421,-0.555556,0,80,unavailable,5.8,0.5,7.3,"skin: 7.3 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241233,KRTAP5-8,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 73.6842% (minimum 75%, Missing); cerebral cortex: 73.6842% (minimum 75%, Missing); kidney: 19.4444% (minimum 75%, Missing); skin: 16.0920% (minimum 65%, Missing)",-0.48908,0.0368421,-0.555556,0,80,unavailable,5.8,0.5,7.3,"skin: 7.3 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241233,KRTAP5-8,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 73.6842% (minimum 75%, Missing); cerebral cortex: 73.6842% (minimum 75%, Missing); kidney: 19.4444% (minimum 75%, Missing); skin: 16.0920% (minimum 65%, Missing)",-0.48908,0.0368421,-0.555556,0,80,unavailable,5.8,0.5,7.3,"skin: 7.3 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241233,KRTAP5-8,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 73.6842% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.6842% (minimum 75%, Baseline (adaptation disabled)); kidney: 19.4444% (minimum 75%, Baseline (adaptation disabled)); skin: 16.0920% (minimum 65%, Baseline (adaptation disabled))",-0.48908,0.0368421,-0.555556,0,80,unavailable,5.8,0.5,7.3,"skin: 7.3 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241233,KRTAP5-8,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.6667% (minimum 95%, Missing); adrenal gland: 53.6278% (minimum 99%, Missing); amygdala: 56.1056% (minimum 99%, Missing); basal ganglia: 55.7377% (minimum 99%, Missing); bone marrow: 31.6574% (minimum 98%, Approved); cerebellum: 53.7975% (minimum 99%, Missing); cerebral cortex: 48.8506% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 48.9914% (minimum 97%, Missing); duodenum: 51.2048% (minimum 99%, Missing); esophagus: 46.8320% (minimum 95%, Approved); heart muscle: 50.2959% (minimum 99%, Missing); hippocampal formation: 57.2391% (minimum 99%, Missing); hypothalamus: 53.9683% (minimum 99%, Missing); kidney: 51.6717% (minimum 99%, Missing); liver: 39.7196% (minimum 99%, Missing); lung: 54.6624% (minimum 99%, Missing); lymph node: 51.6717% (minimum 97%, Missing); midbrain: 55.0162% (minimum 99%, Missing); pancreas: 46.0705% (minimum 99%, Missing); parathyroid gland: 45.4545% (minimum 97%, Missing); pituitary gland: 61.1511% (minimum 99%, Missing); rectum: 47.3538% (minimum 97%, Missing); retina: 55.1948% (minimum 99%, Missing); salivary gland: 52.1472% (minimum 97%, Missing); skeletal muscle: 54.4872% (minimum 99%, Missing); skin: 52.1472% (minimum 95%, Missing); small intestine: 54.3131% (minimum 99%, Missing); smooth muscle: 49.2754% (minimum 99%, Missing); spinal cord: 55.3746% (minimum 99%, Missing); spleen: 50.1475% (minimum 95%, Missing); stomach: 49.5627% (minimum 97%, Missing); thymus: 53.7975% (minimum 95%, Missing); thyroid gland: 46.7033% (minimum 95%, Missing); tongue: 56.6667% (minimum 97%, Missing); urinary bladder: 51.6717% (minimum 97%, Missing)",-0.482967,-0.515455,-0.663426,0,3,partial,36.7,20.4,19.4,"bone marrow: 36.7 nTPM (vital, limit 2); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 2); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (manageable, limit 5); esophagus: 19.3 nTPM (protected, limit 4); rectum: 18.9 nTPM (protected, limit 2); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 2); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 2); spleen: 16.9 nTPM (manageable, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 2); urinary bladder: 15.9 nTPM (protected, limit 2); skin: 15.6 nTPM (manageable, limit 5); salivary gland: 15.6 nTPM (protected, limit 2); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 2); adipose tissue: 13 nTPM (manageable, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241258,CRCP,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.6667% (minimum 65%, Missing); adrenal gland: 53.6278% (minimum 75%, Missing); amygdala: 56.1056% (minimum 75%, Missing); basal ganglia: 55.7377% (minimum 75%, Missing); bone marrow: 31.6574% (minimum 70%, Approved); cerebellum: 53.7975% (minimum 75%, Missing); cerebral cortex: 48.8506% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 48.9914% (minimum 70%, Missing); duodenum: 51.2048% (minimum 75%, Missing); esophagus: 46.8320% (minimum 65%, Approved); heart muscle: 50.2959% (minimum 75%, Missing); hippocampal formation: 57.2391% (minimum 75%, Missing); hypothalamus: 53.9683% (minimum 75%, Missing); kidney: 51.6717% (minimum 75%, Missing); liver: 39.7196% (minimum 75%, Missing); lung: 54.6624% (minimum 75%, Missing); lymph node: 51.6717% (minimum 70%, Missing); midbrain: 55.0162% (minimum 75%, Missing); pancreas: 46.0705% (minimum 75%, Missing); parathyroid gland: 45.4545% (minimum 70%, Missing); pituitary gland: 61.1511% (minimum 75%, Missing); rectum: 47.3538% (minimum 70%, Missing); retina: 55.1948% (minimum 75%, Missing); salivary gland: 52.1472% (minimum 70%, Missing); skeletal muscle: 54.4872% (minimum 75%, Missing); skin: 52.1472% (minimum 65%, Missing); small intestine: 54.3131% (minimum 75%, Missing); smooth muscle: 49.2754% (minimum 75%, Missing); spinal cord: 55.3746% (minimum 75%, Missing); spleen: 50.1475% (minimum 65%, Missing); stomach: 49.5627% (minimum 70%, Missing); thymus: 53.7975% (minimum 65%, Missing); thyroid gland: 46.7033% (minimum 65%, Missing); tongue: 56.6667% (minimum 70%, Missing); urinary bladder: 51.6717% (minimum 70%, Missing)",-0.182967,-0.245455,-0.383426,0,3,partial,36.7,20.4,19.4,"bone marrow: 36.7 nTPM (vital, limit 2); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 2); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (manageable, limit 5); esophagus: 19.3 nTPM (protected, limit 4); rectum: 18.9 nTPM (protected, limit 2); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 2); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 2); spleen: 16.9 nTPM (manageable, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 2); urinary bladder: 15.9 nTPM (protected, limit 2); skin: 15.6 nTPM (manageable, limit 5); salivary gland: 15.6 nTPM (protected, limit 2); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 2); adipose tissue: 13 nTPM (manageable, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241258,CRCP,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.6667% (minimum 65%, Missing); adrenal gland: 53.6278% (minimum 75%, Missing); amygdala: 56.1056% (minimum 75%, Missing); basal ganglia: 55.7377% (minimum 75%, Missing); bone marrow: 31.6574% (minimum 70%, Approved); cerebellum: 53.7975% (minimum 75%, Missing); cerebral cortex: 48.8506% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 48.9914% (minimum 70%, Missing); duodenum: 51.2048% (minimum 75%, Missing); esophagus: 46.8320% (minimum 65%, Approved); heart muscle: 50.2959% (minimum 75%, Missing); hippocampal formation: 57.2391% (minimum 75%, Missing); hypothalamus: 53.9683% (minimum 75%, Missing); kidney: 51.6717% (minimum 75%, Missing); liver: 39.7196% (minimum 75%, Missing); lung: 54.6624% (minimum 75%, Missing); lymph node: 51.6717% (minimum 70%, Missing); midbrain: 55.0162% (minimum 75%, Missing); pancreas: 46.0705% (minimum 75%, Missing); parathyroid gland: 45.4545% (minimum 70%, Missing); pituitary gland: 61.1511% (minimum 75%, Missing); rectum: 47.3538% (minimum 70%, Missing); retina: 55.1948% (minimum 75%, Missing); salivary gland: 52.1472% (minimum 70%, Missing); skeletal muscle: 54.4872% (minimum 75%, Missing); skin: 52.1472% (minimum 65%, Missing); small intestine: 54.3131% (minimum 75%, Missing); smooth muscle: 49.2754% (minimum 75%, Missing); spinal cord: 55.3746% (minimum 75%, Missing); spleen: 50.1475% (minimum 65%, Missing); stomach: 49.5627% (minimum 70%, Missing); thymus: 53.7975% (minimum 65%, Missing); thyroid gland: 46.7033% (minimum 65%, Missing); tongue: 56.6667% (minimum 70%, Missing); urinary bladder: 51.6717% (minimum 70%, Missing)",-0.182967,-0.245455,-0.383426,0,3,partial,36.7,20.4,19.4,"bone marrow: 36.7 nTPM (vital, limit 2); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 3); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (manageable, limit 5); esophagus: 19.3 nTPM (protected, limit 4); rectum: 18.9 nTPM (protected, limit 3); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 3); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 3); spleen: 16.9 nTPM (manageable, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 3); urinary bladder: 15.9 nTPM (protected, limit 3); skin: 15.6 nTPM (manageable, limit 5); salivary gland: 15.6 nTPM (protected, limit 3); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 3); adipose tissue: 13 nTPM (manageable, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241258,CRCP,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.6667% (minimum 65%, Missing); adrenal gland: 53.6278% (minimum 75%, Missing); amygdala: 56.1056% (minimum 75%, Missing); basal ganglia: 55.7377% (minimum 75%, Missing); bone marrow: 31.6574% (minimum 70%, Approved); cerebellum: 53.7975% (minimum 75%, Missing); cerebral cortex: 48.8506% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 48.9914% (minimum 70%, Missing); duodenum: 51.2048% (minimum 75%, Missing); esophagus: 46.8320% (minimum 65%, Approved); heart muscle: 50.2959% (minimum 75%, Missing); hippocampal formation: 57.2391% (minimum 75%, Missing); hypothalamus: 53.9683% (minimum 75%, Missing); kidney: 51.6717% (minimum 75%, Missing); liver: 39.7196% (minimum 75%, Missing); lung: 54.6624% (minimum 75%, Missing); lymph node: 51.6717% (minimum 70%, Missing); midbrain: 55.0162% (minimum 75%, Missing); pancreas: 46.0705% (minimum 75%, Missing); parathyroid gland: 45.4545% (minimum 70%, Missing); pituitary gland: 61.1511% (minimum 75%, Missing); rectum: 47.3538% (minimum 70%, Missing); retina: 55.1948% (minimum 75%, Missing); salivary gland: 52.1472% (minimum 70%, Missing); skeletal muscle: 54.4872% (minimum 75%, Missing); skin: 52.1472% (minimum 65%, Missing); small intestine: 54.3131% (minimum 75%, Missing); smooth muscle: 49.2754% (minimum 75%, Missing); spinal cord: 55.3746% (minimum 75%, Missing); spleen: 50.1475% (minimum 65%, Missing); stomach: 49.5627% (minimum 70%, Missing); thymus: 53.7975% (minimum 65%, Missing); thyroid gland: 46.7033% (minimum 65%, Missing); tongue: 56.6667% (minimum 70%, Missing); urinary bladder: 51.6717% (minimum 70%, Missing)",-0.182967,-0.245455,-0.383426,0,3,partial,36.7,20.4,19.4,"bone marrow: 36.7 nTPM (vital, limit 2); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 3); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (manageable, limit 5); esophagus: 19.3 nTPM (protected, limit 4); rectum: 18.9 nTPM (protected, limit 3); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 3); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 3); spleen: 16.9 nTPM (manageable, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 3); urinary bladder: 15.9 nTPM (protected, limit 3); skin: 15.6 nTPM (manageable, limit 5); salivary gland: 15.6 nTPM (protected, limit 3); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 3); adipose tissue: 13 nTPM (manageable, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241258,CRCP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.6667% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 53.6278% (minimum 75%, Baseline (adaptation disabled)); amygdala: 56.1056% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.7377% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 31.6574% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 53.7975% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 48.8506% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 75%, Baseline (adaptation disabled)); colon: 48.9914% (minimum 70%, Baseline (adaptation disabled)); duodenum: 51.2048% (minimum 75%, Baseline (adaptation disabled)); esophagus: 46.8320% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 50.2959% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.2391% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.9683% (minimum 75%, Baseline (adaptation disabled)); kidney: 51.6717% (minimum 75%, Baseline (adaptation disabled)); liver: 39.7196% (minimum 75%, Baseline (adaptation disabled)); lung: 54.6624% (minimum 75%, Baseline (adaptation disabled)); lymph node: 51.6717% (minimum 70%, Baseline (adaptation disabled)); midbrain: 55.0162% (minimum 75%, Baseline (adaptation disabled)); pancreas: 46.0705% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 45.4545% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 61.1511% (minimum 75%, Baseline (adaptation disabled)); rectum: 47.3538% (minimum 70%, Baseline (adaptation disabled)); retina: 55.1948% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 52.1472% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 54.4872% (minimum 75%, Baseline (adaptation disabled)); skin: 52.1472% (minimum 65%, Baseline (adaptation disabled)); small intestine: 54.3131% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 49.2754% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 55.3746% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.1475% (minimum 65%, Baseline (adaptation disabled)); stomach: 49.5627% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.7975% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 46.7033% (minimum 65%, Baseline (adaptation disabled)); tongue: 56.6667% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.6717% (minimum 70%, Baseline (adaptation disabled))",-0.182967,-0.245455,-0.433426,0,3,partial,36.7,20.4,19.4,"bone marrow: 36.7 nTPM (vital, limit 1); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 3); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (manageable, limit 5); esophagus: 19.3 nTPM (protected, limit 3); rectum: 18.9 nTPM (protected, limit 3); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 3); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 3); spleen: 16.9 nTPM (manageable, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 3); urinary bladder: 15.9 nTPM (protected, limit 3); skin: 15.6 nTPM (manageable, limit 5); salivary gland: 15.6 nTPM (protected, limit 3); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 3); adipose tissue: 13 nTPM (manageable, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241258,CRCP,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,2,partial,0,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241476,SSX2,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241476,SSX2,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241476,SSX2,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241476,SSX2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.337805,0.3,0.25,0,2,partial,0,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000241476,SSX2,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.8024% (minimum 99%, Missing); basal ganglia: 98.6547% (minimum 99%, Missing); hippocampal formation: 98.8024% (minimum 99%, Missing); hypothalamus: 98.7531% (minimum 99%, Missing); liver: 91.4972% (minimum 99%, Missing)",0.0479839,0.0244751,-0.0750277,0,3,partial,18.4,1.1,1,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242220,TCP10L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347984,0.294475,0.164972,0,3,partial,18.4,1.1,1,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242220,TCP10L,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347984,0.294475,0.164972,0,3,partial,18.4,1.1,1,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242220,TCP10L,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347984,0.294475,0.164972,0,3,partial,18.4,1.1,1,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242220,TCP10L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344975,0.294475,0.164972,0,3,partial,18.4,1.1,1,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242220,TCP10L,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.0482759,0.0291372,0.00612903,0,80,unavailable,0.9,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242221,PSG2,admission_only,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.348276,0.299137,0.246129,0,80,unavailable,0.9,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242221,PSG2,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.348276,0.299137,0.246129,0,80,unavailable,0.9,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242221,PSG2,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.348276,0.299137,0.246129,0,80,unavailable,0.9,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242221,PSG2,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.348276,0.299137,0.246129,0,80,unavailable,0.9,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242221,PSG2,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242362,CT47A2,admission_only,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242362,CT47A2,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242362,CT47A2,grid_revised,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242362,CT47A2,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242362,CT47A2,current_fixed,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242389,RBMY1E,admission_only,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242389,RBMY1E,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242389,RBMY1E,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242389,RBMY1E,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242389,RBMY1E,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 97.9798% (minimum 99%, Missing); colon: 87.3874% (minimum 97%, Missing); heart muscle: 98.6441% (minimum 99%, Missing); kidney: 98.1450% (minimum 99%, Missing); lung: 98.1450% (minimum 99%, Missing); skeletal muscle: 98.9796% (minimum 99%, Missing); small intestine: 97.3244% (minimum 99%, Missing); smooth muscle: 98.9796% (minimum 99%, Missing); spinal cord: 98.8115% (minimum 99%, Missing); stomach: 95.8814% (minimum 97%, Missing); urinary bladder: 93.4189% (minimum 97%, Missing)",0.0167774,-0.0961261,-0.0167559,0,80,unavailable,1.6,8.4,2,"colon: 8.4 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242441,GTF2A1L,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316777,0.173874,0.223244,0,80,unavailable,1.6,8.4,2,"colon: 8.4 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242441,GTF2A1L,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316777,0.173874,0.223244,0,80,unavailable,1.6,8.4,2,"colon: 8.4 nTPM (protected, limit 3); urinary bladder: 4.1 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242441,GTF2A1L,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316777,0.173874,0.223244,0,80,unavailable,1.6,8.4,2,"colon: 8.4 nTPM (protected, limit 3); urinary bladder: 4.1 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242441,GTF2A1L,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316777,0.173874,0.223244,0,80,unavailable,1.6,8.4,2,"colon: 8.4 nTPM (protected, limit 3); urinary bladder: 4.1 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242441,GTF2A1L,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 95.3566% (minimum 99%, Missing); cerebral cortex: 98.2906% (minimum 99%, Missing); choroid plexus: 98.9673% (minimum 99%, Missing); heart muscle: 98.9673% (minimum 99%, Missing); kidney: 98.9673% (minimum 99%, Missing); parathyroid gland: 96.9646% (minimum 97%, Missing); retina: 95.8333% (minimum 99%, Missing); smooth muscle: 97.4576% (minimum 99%, Missing)",0.039673,-0.000354132,-0.0364345,0,80,unavailable,2.8,1.8,0.6,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242715,CCDC169,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339673,0.269646,0.203566,0,80,unavailable,2.8,1.8,0.6,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242715,CCDC169,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339673,0.269646,0.203566,0,80,unavailable,2.8,1.8,0.6,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242715,CCDC169,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339673,0.269646,0.203566,0,80,unavailable,2.8,1.8,0.6,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242715,CCDC169,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339673,0.269646,0.203566,0,80,unavailable,2.8,1.8,0.6,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242715,CCDC169,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7107% (minimum 95%, Missing); adrenal gland: 94.3038% (minimum 99%, Missing); amygdala: 90.8537% (minimum 99%, Missing); basal ganglia: 86.6279% (minimum 99%, Missing); bone marrow: 96.7532% (minimum 99%, Missing); cerebellum: 84.1808% (minimum 99%, Missing); cerebral cortex: 91.4110% (minimum 99%, Missing); choroid plexus: 94.3038% (minimum 99%, Missing); colon: 94.3038% (minimum 97%, Missing); esophagus: 96.1290% (minimum 97%, Missing); heart muscle: 93.7107% (minimum 99%, Missing); hippocampal formation: 90.8537% (minimum 99%, Missing); hypothalamus: 88.6905% (minimum 99%, Missing); kidney: 90.3030% (minimum 99%, Missing); liver: 97.3856% (minimum 99%, Missing); lung: 94.9045% (minimum 99%, Missing); lymph node: 94.9045% (minimum 97%, Missing); midbrain: 91.9753% (minimum 99%, Missing); pancreas: 93.1250% (minimum 99%, Missing); parathyroid gland: 87.1345% (minimum 97%, Missing); pituitary gland: 90.3030% (minimum 99%, Missing); retina: 83.2402% (minimum 99%, Missing); salivary gland: 93.7107% (minimum 97%, Missing); skeletal muscle: 94.3038% (minimum 99%, Missing); small intestine: 94.9045% (minimum 99%, Missing); smooth muscle: 93.7107% (minimum 99%, Missing); spinal cord: 93.7107% (minimum 99%, Missing); spleen: 92.5466% (minimum 95%, Missing); stomach: 94.9045% (minimum 97%, Missing); thymus: 87.6471% (minimum 95%, Missing); thyroid gland: 84.1808% (minimum 95%, Missing); tongue: 94.3038% (minimum 97%, Missing); urinary bladder: 94.3038% (minimum 97%, Missing)",-0.108192,-0.098655,-0.157598,0,80,unavailable,3,2.2,2.8,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242852,ZNF709,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191808,0.171345,0.0824022,0,80,unavailable,3,2.2,2.8,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242852,ZNF709,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191808,0.171345,0.0824022,0,80,unavailable,3,2.2,2.8,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242852,ZNF709,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191808,0.171345,0.0824022,0,80,unavailable,3,2.2,2.8,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242852,ZNF709,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191808,0.171345,0.0824022,0,80,unavailable,3,2.2,2.8,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242852,ZNF709,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242875,RBMY1B,admission_only,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242875,RBMY1B,selectivity_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242875,RBMY1B,grid_revised,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242875,RBMY1B,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242875,RBMY1B,current_fixed,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6916% (minimum 99%, Missing); bone marrow: 98.6916% (minimum 99%, Missing); choroid plexus: 95.6522% (minimum 99%, Missing); lung: 98.8764% (minimum 99%, Missing); pancreas: 98.6916% (minimum 99%, Missing); retina: 88.7395% (minimum 99%, Missing); skeletal muscle: 98.8764% (minimum 99%, Missing); small intestine: 98.8764% (minimum 99%, Missing)",0.0314126,0.00777778,-0.102605,0,80,unavailable,6.7,1.2,1,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242950,ERVW-1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Loriot 2025 · preferential"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331413,0.277778,0.137395,0,80,unavailable,6.7,1.2,1,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242950,ERVW-1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Loriot 2025 · preferential"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331413,0.277778,0.137395,0,80,unavailable,6.7,1.2,1,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242950,ERVW-1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Loriot 2025 · preferential"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331413,0.277778,0.137395,0,80,unavailable,6.7,1.2,1,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242950,ERVW-1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Loriot 2025 · preferential"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331413,0.277778,0.137395,0,80,unavailable,6.7,1.2,1,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000242950,ERVW-1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Loriot 2025 · preferential"
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243073,PRAMEF4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243073,PRAMEF4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243073,PRAMEF4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243073,PRAMEF4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243073,PRAMEF4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0.5,0,0.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243130,PSG11,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.5,0,0.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243130,PSG11,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.5,0,0.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243130,PSG11,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.5,0,0.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243130,PSG11,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.348054,0.3,0.240347,0,1,partial,0.5,0,0.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243130,PSG11,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 72.1676% (minimum 90%, Supported)",0.05,-0.178324,0.00928367,0,2,partial,1,53.8,3.2,"parathyroid gland: 53.8 nTPM (protected, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243137,PSG4,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.121676,0.249284,0,2,partial,1,53.8,3.2,"parathyroid gland: 53.8 nTPM (protected, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243137,PSG4,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.121676,0.249284,0,2,partial,1,53.8,3.2,"parathyroid gland: 53.8 nTPM (protected, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243137,PSG4,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.121676,0.249284,0,2,partial,1,53.8,3.2,"parathyroid gland: 53.8 nTPM (protected, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243137,PSG4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.327575,0.0216762,0.242883,0,2,partial,1,53.8,3.2,"parathyroid gland: 53.8 nTPM (protected, limit 3)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243137,PSG4,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0477043,0.02954,0.00405306,0,80,unavailable,1.3,0.1,0.5,"lung: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243543,WFDC6,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347704,0.29954,0.244053,0,80,unavailable,1.3,0.1,0.5,"lung: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243543,WFDC6,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347704,0.29954,0.244053,0,80,unavailable,1.3,0.1,0.5,"lung: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243543,WFDC6,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347704,0.29954,0.244053,0,80,unavailable,1.3,0.1,0.5,"lung: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243543,WFDC6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347704,0.29954,0.244053,0,80,unavailable,1.3,0.1,0.5,"lung: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243543,WFDC6,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.8972% (minimum 90%, Approved); adrenal gland: 69.6429% (minimum 99%, Missing); amygdala: 78.0000% (minimum 99%, Missing); basal ganglia: 72.2222% (minimum 99%, Missing); bone marrow: 81.2500% (minimum 99%, Missing); cerebellum: 75.7282% (minimum 99%, Missing); cerebral cortex: 75.3623% (minimum 99%, Missing); choroid plexus: 63.6735% (minimum 99%, Missing); colon: 72.5581% (minimum 97%, Missing); duodenum: 71.8894% (minimum 99%, Missing); esophagus: 69.6429% (minimum 97%, Missing); heart muscle: 64.1975% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 76.8473% (minimum 99%, Missing); kidney: 74.6411% (minimum 99%, Missing); liver: 75.7282% (minimum 98%, Approved); lung: 73.5849% (minimum 99%, Missing); lymph node: 62.1514% (minimum 95%, Approved); midbrain: 79.5918% (minimum 99%, Missing); pancreas: 78.7879% (minimum 99%, Missing); parathyroid gland: 69.0265% (minimum 95%, Approved); pituitary gland: 77.2277% (minimum 99%, Missing); rectum: 66.9528% (minimum 97%, Missing); retina: 69.9552% (minimum 99%, Missing); salivary gland: 71.8894% (minimum 97%, Missing); skeletal muscle: 58.6466% (minimum 99%, Missing); skin: 60.2317% (minimum 95%, Missing); small intestine: 75.3623% (minimum 99%, Missing); smooth muscle: 68.4211% (minimum 98%, Approved); spinal cord: 78.0000% (minimum 99%, Missing); spleen: 66.1017% (minimum 90%, Approved); stomach: 72.8972% (minimum 97%, Missing); thymus: 66.3830% (minimum 95%, Missing); thyroid gland: 65.8228% (minimum 95%, Missing); tongue: 64.1975% (minimum 97%, Missing); urinary bladder: 76.4706% (minimum 97%, Missing)",-0.347683,-0.328486,-0.403534,0,2,partial,11,9.5,10.3,"skeletal muscle: 11 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 4); choroid plexus: 8.9 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); rectum: 7.7 nTPM (protected, limit 2); smooth muscle: 7.2 nTPM (vital, limit 2); parathyroid gland: 7 nTPM (protected, limit 4); adrenal gland: 6.8 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 2); retina: 6.7 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 2); stomach: 5.8 nTPM (protected, limit 2); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 2); cerebellum: 5 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243667,DNAAF10,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.6429% (minimum 75%, Missing); basal ganglia: 72.2222% (minimum 75%, Missing); choroid plexus: 63.6735% (minimum 75%, Missing); duodenum: 71.8894% (minimum 75%, Missing); esophagus: 69.6429% (minimum 70%, Missing); heart muscle: 64.1975% (minimum 75%, Missing); kidney: 74.6411% (minimum 75%, Missing); lung: 73.5849% (minimum 75%, Missing); lymph node: 62.1514% (minimum 65%, Approved); rectum: 66.9528% (minimum 70%, Missing); retina: 69.9552% (minimum 75%, Missing); skeletal muscle: 58.6466% (minimum 75%, Missing); skin: 60.2317% (minimum 65%, Missing); smooth muscle: 68.4211% (minimum 70%, Approved); tongue: 64.1975% (minimum 70%, Missing)",-0.0476834,-0.0580247,-0.163534,0,2,partial,11,9.5,10.3,"skeletal muscle: 11 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 4); choroid plexus: 8.9 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); rectum: 7.7 nTPM (protected, limit 2); smooth muscle: 7.2 nTPM (vital, limit 2); parathyroid gland: 7 nTPM (protected, limit 4); adrenal gland: 6.8 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 2); retina: 6.7 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 2); stomach: 5.8 nTPM (protected, limit 2); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 2); cerebellum: 5 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243667,DNAAF10,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.6429% (minimum 75%, Missing); basal ganglia: 72.2222% (minimum 75%, Missing); choroid plexus: 63.6735% (minimum 75%, Missing); duodenum: 71.8894% (minimum 75%, Missing); esophagus: 69.6429% (minimum 70%, Missing); heart muscle: 64.1975% (minimum 75%, Missing); kidney: 74.6411% (minimum 75%, Missing); lung: 73.5849% (minimum 75%, Missing); lymph node: 62.1514% (minimum 65%, Approved); rectum: 66.9528% (minimum 70%, Missing); retina: 69.9552% (minimum 75%, Missing); skeletal muscle: 58.6466% (minimum 75%, Missing); skin: 60.2317% (minimum 65%, Missing); smooth muscle: 68.4211% (minimum 70%, Approved); tongue: 64.1975% (minimum 70%, Missing)",-0.0476834,-0.0580247,-0.163534,0,2,partial,11,9.5,10.3,"skeletal muscle: 11 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 4); choroid plexus: 8.9 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 3); heart muscle: 8.7 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); rectum: 7.7 nTPM (protected, limit 3); smooth muscle: 7.2 nTPM (vital, limit 2); parathyroid gland: 7 nTPM (protected, limit 4); adrenal gland: 6.8 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 3); retina: 6.7 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 3); stomach: 5.8 nTPM (protected, limit 3); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 2); cerebellum: 5 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243667,DNAAF10,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.6429% (minimum 75%, Missing); basal ganglia: 72.2222% (minimum 75%, Missing); choroid plexus: 63.6735% (minimum 75%, Missing); duodenum: 71.8894% (minimum 75%, Missing); esophagus: 69.6429% (minimum 70%, Missing); heart muscle: 64.1975% (minimum 75%, Missing); kidney: 74.6411% (minimum 75%, Missing); lung: 73.5849% (minimum 75%, Missing); lymph node: 62.1514% (minimum 65%, Approved); rectum: 66.9528% (minimum 70%, Missing); retina: 69.9552% (minimum 75%, Missing); skeletal muscle: 58.6466% (minimum 75%, Missing); skin: 60.2317% (minimum 65%, Missing); smooth muscle: 68.4211% (minimum 70%, Approved); tongue: 64.1975% (minimum 70%, Missing)",-0.0476834,-0.0580247,-0.163534,0,2,partial,11,9.5,10.3,"skeletal muscle: 11 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 4); choroid plexus: 8.9 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 3); heart muscle: 8.7 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); rectum: 7.7 nTPM (protected, limit 3); smooth muscle: 7.2 nTPM (vital, limit 2); parathyroid gland: 7 nTPM (protected, limit 4); adrenal gland: 6.8 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 3); retina: 6.7 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 3); stomach: 5.8 nTPM (protected, limit 3); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 2); cerebellum: 5 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243667,DNAAF10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.6429% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 72.2222% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 63.6735% (minimum 75%, Baseline (adaptation disabled)); duodenum: 71.8894% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.6429% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.1975% (minimum 75%, Baseline (adaptation disabled)); kidney: 74.6411% (minimum 75%, Baseline (adaptation disabled)); lung: 73.5849% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.1514% (minimum 70%, Baseline (adaptation disabled)); parathyroid gland: 69.0265% (minimum 70%, Baseline (adaptation disabled)); rectum: 66.9528% (minimum 70%, Baseline (adaptation disabled)); retina: 69.9552% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 58.6466% (minimum 75%, Baseline (adaptation disabled)); skin: 60.2317% (minimum 65%, Baseline (adaptation disabled)); smooth muscle: 68.4211% (minimum 75%, Baseline (adaptation disabled)); tongue: 64.1975% (minimum 70%, Baseline (adaptation disabled))",-0.0476834,-0.0784861,-0.163534,0,2,partial,11,9.5,10.3,"skeletal muscle: 11 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 3); choroid plexus: 8.9 nTPM (vital, limit 1); heart muscle: 8.7 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 3); thyroid gland: 8.1 nTPM (manageable, limit 5); spleen: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); rectum: 7.7 nTPM (protected, limit 3); smooth muscle: 7.2 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 3); esophagus: 6.8 nTPM (protected, limit 3); adrenal gland: 6.8 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 3); stomach: 5.8 nTPM (protected, limit 3); adipose tissue: 5.8 nTPM (manageable, limit 5); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243667,DNAAF10,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.7806% (minimum 99%, Missing); basal ganglia: 90.8000% (minimum 99%, Missing); choroid plexus: 62.5344% (minimum 99%, Missing); hippocampal formation: 93.0328% (minimum 99%, Missing); hypothalamus: 92.2764% (minimum 99%, Missing); liver: 89.3701% (minimum 95%, Enhanced); lung: 90.4382% (minimum 99%, Missing); pituitary gland: 91.9028% (minimum 99%, Missing); retina: 94.1909% (minimum 99%, Missing); spinal cord: 98.6957% (minimum 99%, Missing)",0.0412664,0.03,-0.364656,0,5,partial,13.6,0.2,1,"choroid plexus: 13.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243710,CFAP57,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 62.5344% (minimum 75%, Missing)",0.341266,0.3,-0.124656,0,5,partial,13.6,0.2,1,"choroid plexus: 13.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243710,CFAP57,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 62.5344% (minimum 75%, Missing)",0.341266,0.3,-0.124656,0,5,partial,13.6,0.2,1,"choroid plexus: 13.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243710,CFAP57,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 62.5344% (minimum 75%, Missing)",0.341266,0.3,-0.124656,0,5,partial,13.6,0.2,1,"choroid plexus: 13.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243710,CFAP57,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 62.5344% (minimum 75%, Baseline (adaptation disabled))",0.307806,0.291266,-0.124656,0,5,partial,13.6,0.2,1,"choroid plexus: 13.6 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243710,CFAP57,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000243729,OR5V1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000243729,OR5V1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000243729,OR5V1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000243729,OR5V1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000243729,OR5V1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.2025% (minimum 99%, Missing); basal ganglia: 87.3563% (minimum 99%, Missing); cerebellum: 93.8272% (minimum 95%, Enhanced); heart muscle: 93.8272% (minimum 95%, Enhanced); hippocampal formation: 97.4359% (minimum 99%, Missing); hypothalamus: 86.3636% (minimum 99%, Missing); midbrain: 91.5663% (minimum 99%, Missing); pituitary gland: 97.4359% (minimum 99%, Missing); retina: 97.4359% (minimum 99%, Missing); spinal cord: 98.7013% (minimum 99%, Missing)",0.05,0.03,-0.126364,0,4,partial,1.2,0,0.1,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243978,RTL9,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.113636,0,4,partial,1.2,0,0.1,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243978,RTL9,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.113636,0,4,partial,1.2,0,0.1,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243978,RTL9,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.113636,0,4,partial,1.2,0,0.1,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243978,RTL9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.337013,0.3,0.113636,0,4,partial,1.2,0,0.1,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000243978,RTL9,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 50.0000% (minimum 97%, Missing); skin: 10.5263% (minimum 95%, Missing)",-0.844737,-0.47,0.01,0,80,unavailable,0,0.2,1.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244057,LCE3C,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 50.0000% (minimum 70%, Missing); skin: 10.5263% (minimum 65%, Missing)",-0.544737,-0.2,0.25,0,80,unavailable,0,0.2,1.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244057,LCE3C,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 50.0000% (minimum 70%, Missing); skin: 10.5263% (minimum 65%, Missing)",-0.544737,-0.2,0.25,0,80,unavailable,0,0.2,1.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244057,LCE3C,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 50.0000% (minimum 70%, Missing); skin: 10.5263% (minimum 65%, Missing)",-0.544737,-0.2,0.25,0,80,unavailable,0,0.2,1.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244057,LCE3C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 50.0000% (minimum 70%, Baseline (adaptation disabled)); skin: 10.5263% (minimum 65%, Baseline (adaptation disabled))",-0.544737,-0.2,0.25,0,80,unavailable,0,0.2,1.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244057,LCE3C,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 98.5936% (minimum 99%, Missing); amygdala: 97.9412% (minimum 99%, Missing); basal ganglia: 98.1577% (minimum 99%, Missing); cerebellum: 98.8864% (minimum 99%, Missing); cerebral cortex: 98.3026% (minimum 99%, Missing); hippocampal formation: 98.0854% (minimum 99%, Missing); hypothalamus: 98.0132% (minimum 99%, Missing); kidney: 97.5110% (minimum 99%, Missing); lung: 98.9599% (minimum 99%, Missing); midbrain: 97.8692% (minimum 99%, Missing); pituitary gland: 97.9412% (minimum 99%, Missing); spinal cord: 98.3026% (minimum 99%, Missing)",0.0222628,0.0123009,-0.0148902,0,80,unavailable,3.4,2.4,3.8,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000244219,TMEM225B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.322263,0.282301,0.22511,0,80,unavailable,3.4,2.4,3.8,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000244219,TMEM225B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.322263,0.282301,0.22511,0,80,unavailable,3.4,2.4,3.8,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000244219,TMEM225B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.322263,0.282301,0.22511,0,80,unavailable,3.4,2.4,3.8,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000244219,TMEM225B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.322263,0.282301,0.22511,0,80,unavailable,3.4,2.4,3.8,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000244219,TMEM225B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.05,0.0193617,0.01,9,5,partial,0,0.2,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244234,GMCL2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.35,0.289362,0.25,9,5,partial,0,0.2,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244234,GMCL2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.35,0.289362,0.25,9,5,partial,0,0.2,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244234,GMCL2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.35,0.289362,0.25,9,5,partial,0,0.2,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244234,GMCL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.35,0.289362,0.25,9,5,partial,0,0.2,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244234,GMCL2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244395,RBMY1D,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244395,RBMY1D,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244395,RBMY1D,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244395,RBMY1D,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244395,RBMY1D,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8950% (minimum 99%, Missing); duodenum: 98.6226% (minimum 99%, Missing); kidney: 98.6226% (minimum 99%, Missing); lung: 98.3516% (minimum 99%, Missing); parathyroid gland: 83.2558% (minimum 97%, Missing); small intestine: 98.6226% (minimum 99%, Missing)",0.0362259,-0.137442,-0.00648352,0,80,unavailable,0.6,7.2,0.5,"parathyroid gland: 7.2 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244476,ERVFRD-1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336226,0.132558,0.233516,0,80,unavailable,0.6,7.2,0.5,"parathyroid gland: 7.2 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244476,ERVFRD-1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336226,0.132558,0.233516,0,80,unavailable,0.6,7.2,0.5,"parathyroid gland: 7.2 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244476,ERVFRD-1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336226,0.132558,0.233516,0,80,unavailable,0.6,7.2,0.5,"parathyroid gland: 7.2 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244476,ERVFRD-1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336226,0.132558,0.233516,0,80,unavailable,0.6,7.2,0.5,"parathyroid gland: 7.2 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244476,ERVFRD-1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 92.8571% (minimum 99%, Missing)",0.05,0.03,-0.0614286,0,5,partial,0.8,0.1,0,,,51,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244588,RAD21L1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.178571,0,5,partial,0.8,0.1,0,,,51,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244588,RAD21L1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.178571,0,5,partial,0.8,0.1,0,,,51,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244588,RAD21L1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.178571,0,5,partial,0.8,0.1,0,,,51,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244588,RAD21L1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.290476,0.178571,0,5,partial,0.8,0.1,0,,,51,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244588,RAD21L1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 20.0000% (minimum 95%, Missing)",-0.75,0.03,0.01,0,80,unavailable,0,0,0.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000244624,KRTAP20-1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 20.0000% (minimum 65%, Missing)",-0.45,0.3,0.25,0,80,unavailable,0,0,0.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000244624,KRTAP20-1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 20.0000% (minimum 65%, Missing)",-0.45,0.3,0.25,0,80,unavailable,0,0,0.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000244624,KRTAP20-1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 20.0000% (minimum 65%, Missing)",-0.45,0.3,0.25,0,80,unavailable,0,0,0.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000244624,KRTAP20-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 20.0000% (minimum 65%, Baseline (adaptation disabled))",-0.45,0.3,0.25,0,80,unavailable,0,0,0.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000244624,KRTAP20-1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.0292% (minimum 95%, Missing); adrenal gland: 54.0928% (minimum 99%, Missing); amygdala: 51.1981% (minimum 99%, Missing); basal ganglia: 54.4605% (minimum 99%, Missing); bone marrow: 55.8849% (minimum 99%, Missing); cerebellum: 54.6928% (minimum 99%, Missing); cerebral cortex: 45.0140% (minimum 99%, Missing); choroid plexus: 45.4288% (minimum 99%, Missing); colon: 48.8567% (minimum 97%, Missing); duodenum: 53.0190% (minimum 99%, Missing); esophagus: 48.0870% (minimum 97%, Missing); heart muscle: 51.6103% (minimum 99%, Missing); hippocampal formation: 55.6907% (minimum 99%, Missing); hypothalamus: 53.6851% (minimum 99%, Missing); kidney: 53.4612% (minimum 99%, Missing); liver: 45.8184% (minimum 99%, Missing); lung: 53.1069% (minimum 99%, Missing); lymph node: 48.9687% (minimum 97%, Missing); midbrain: 56.0315% (minimum 99%, Missing); pancreas: 50.5521% (minimum 99%, Missing); parathyroid gland: 52.0292% (minimum 97%, Missing); pituitary gland: 65.7436% (minimum 99%, Missing); rectum: 51.9449% (minimum 97%, Missing); retina: 58.3789% (minimum 99%, Missing); salivary gland: 54.2760% (minimum 97%, Missing); skeletal muscle: 43.0490% (minimum 99%, Missing); skin: 50.8730% (minimum 95%, Missing); small intestine: 55.9825% (minimum 99%, Missing); smooth muscle: 47.5167% (minimum 99%, Missing); spinal cord: 64.1000% (minimum 99%, Missing); spleen: 55.9337% (minimum 95%, Missing); stomach: 54.1385% (minimum 97%, Missing); thymus: 51.9870% (minimum 95%, Missing); thyroid gland: 56.9778% (minimum 95%, Missing); tongue: 48.4505% (minimum 97%, Missing); urinary bladder: 49.5363% (minimum 97%, Missing)",-0.44127,-0.48913,-0.55951,0,80,unavailable,84.8,69.2,61.9,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 2); tongue: 68.2 nTPM (protected, limit 2); colon: 67.1 nTPM (protected, limit 2); lymph node: 66.8 nTPM (protected, limit 2); urinary bladder: 65.3 nTPM (protected, limit 2); pancreas: 62.7 nTPM (vital, limit 1); skin: 61.9 nTPM (manageable, limit 5); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 2); thymus: 59.2 nTPM (manageable, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 2); adipose tissue: 59.1 nTPM (manageable, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 2); salivary gland: 54 nTPM (protected, limit 2); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); spleen: 50.5 nTPM (manageable, limit 5); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (manageable, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244687,UBE2V1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.0292% (minimum 65%, Missing); adrenal gland: 54.0928% (minimum 75%, Missing); amygdala: 51.1981% (minimum 75%, Missing); basal ganglia: 54.4605% (minimum 75%, Missing); bone marrow: 55.8849% (minimum 75%, Missing); cerebellum: 54.6928% (minimum 75%, Missing); cerebral cortex: 45.0140% (minimum 75%, Missing); choroid plexus: 45.4288% (minimum 75%, Missing); colon: 48.8567% (minimum 70%, Missing); duodenum: 53.0190% (minimum 75%, Missing); esophagus: 48.0870% (minimum 70%, Missing); heart muscle: 51.6103% (minimum 75%, Missing); hippocampal formation: 55.6907% (minimum 75%, Missing); hypothalamus: 53.6851% (minimum 75%, Missing); kidney: 53.4612% (minimum 75%, Missing); liver: 45.8184% (minimum 75%, Missing); lung: 53.1069% (minimum 75%, Missing); lymph node: 48.9687% (minimum 70%, Missing); midbrain: 56.0315% (minimum 75%, Missing); pancreas: 50.5521% (minimum 75%, Missing); parathyroid gland: 52.0292% (minimum 70%, Missing); pituitary gland: 65.7436% (minimum 75%, Missing); rectum: 51.9449% (minimum 70%, Missing); retina: 58.3789% (minimum 75%, Missing); salivary gland: 54.2760% (minimum 70%, Missing); skeletal muscle: 43.0490% (minimum 75%, Missing); skin: 50.8730% (minimum 65%, Missing); small intestine: 55.9825% (minimum 75%, Missing); smooth muscle: 47.5167% (minimum 75%, Missing); spinal cord: 64.1000% (minimum 75%, Missing); spleen: 55.9337% (minimum 65%, Missing); stomach: 54.1385% (minimum 70%, Missing); thymus: 51.9870% (minimum 65%, Missing); thyroid gland: 56.9778% (minimum 65%, Missing); tongue: 48.4505% (minimum 70%, Missing); urinary bladder: 49.5363% (minimum 70%, Missing)",-0.14127,-0.21913,-0.31951,0,80,unavailable,84.8,69.2,61.9,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 2); tongue: 68.2 nTPM (protected, limit 2); colon: 67.1 nTPM (protected, limit 2); lymph node: 66.8 nTPM (protected, limit 2); urinary bladder: 65.3 nTPM (protected, limit 2); pancreas: 62.7 nTPM (vital, limit 1); skin: 61.9 nTPM (manageable, limit 5); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 2); thymus: 59.2 nTPM (manageable, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 2); adipose tissue: 59.1 nTPM (manageable, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 2); salivary gland: 54 nTPM (protected, limit 2); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); spleen: 50.5 nTPM (manageable, limit 5); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (manageable, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244687,UBE2V1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.0292% (minimum 65%, Missing); adrenal gland: 54.0928% (minimum 75%, Missing); amygdala: 51.1981% (minimum 75%, Missing); basal ganglia: 54.4605% (minimum 75%, Missing); bone marrow: 55.8849% (minimum 75%, Missing); cerebellum: 54.6928% (minimum 75%, Missing); cerebral cortex: 45.0140% (minimum 75%, Missing); choroid plexus: 45.4288% (minimum 75%, Missing); colon: 48.8567% (minimum 70%, Missing); duodenum: 53.0190% (minimum 75%, Missing); esophagus: 48.0870% (minimum 70%, Missing); heart muscle: 51.6103% (minimum 75%, Missing); hippocampal formation: 55.6907% (minimum 75%, Missing); hypothalamus: 53.6851% (minimum 75%, Missing); kidney: 53.4612% (minimum 75%, Missing); liver: 45.8184% (minimum 75%, Missing); lung: 53.1069% (minimum 75%, Missing); lymph node: 48.9687% (minimum 70%, Missing); midbrain: 56.0315% (minimum 75%, Missing); pancreas: 50.5521% (minimum 75%, Missing); parathyroid gland: 52.0292% (minimum 70%, Missing); pituitary gland: 65.7436% (minimum 75%, Missing); rectum: 51.9449% (minimum 70%, Missing); retina: 58.3789% (minimum 75%, Missing); salivary gland: 54.2760% (minimum 70%, Missing); skeletal muscle: 43.0490% (minimum 75%, Missing); skin: 50.8730% (minimum 65%, Missing); small intestine: 55.9825% (minimum 75%, Missing); smooth muscle: 47.5167% (minimum 75%, Missing); spinal cord: 64.1000% (minimum 75%, Missing); spleen: 55.9337% (minimum 65%, Missing); stomach: 54.1385% (minimum 70%, Missing); thymus: 51.9870% (minimum 65%, Missing); thyroid gland: 56.9778% (minimum 65%, Missing); tongue: 48.4505% (minimum 70%, Missing); urinary bladder: 49.5363% (minimum 70%, Missing)",-0.14127,-0.21913,-0.31951,0,80,unavailable,84.8,69.2,61.9,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 3); tongue: 68.2 nTPM (protected, limit 3); colon: 67.1 nTPM (protected, limit 3); lymph node: 66.8 nTPM (protected, limit 3); urinary bladder: 65.3 nTPM (protected, limit 3); pancreas: 62.7 nTPM (vital, limit 1); skin: 61.9 nTPM (manageable, limit 5); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 3); thymus: 59.2 nTPM (manageable, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 3); adipose tissue: 59.1 nTPM (manageable, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 3); salivary gland: 54 nTPM (protected, limit 3); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); spleen: 50.5 nTPM (manageable, limit 5); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (manageable, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244687,UBE2V1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.0292% (minimum 65%, Missing); adrenal gland: 54.0928% (minimum 75%, Missing); amygdala: 51.1981% (minimum 75%, Missing); basal ganglia: 54.4605% (minimum 75%, Missing); bone marrow: 55.8849% (minimum 75%, Missing); cerebellum: 54.6928% (minimum 75%, Missing); cerebral cortex: 45.0140% (minimum 75%, Missing); choroid plexus: 45.4288% (minimum 75%, Missing); colon: 48.8567% (minimum 70%, Missing); duodenum: 53.0190% (minimum 75%, Missing); esophagus: 48.0870% (minimum 70%, Missing); heart muscle: 51.6103% (minimum 75%, Missing); hippocampal formation: 55.6907% (minimum 75%, Missing); hypothalamus: 53.6851% (minimum 75%, Missing); kidney: 53.4612% (minimum 75%, Missing); liver: 45.8184% (minimum 75%, Missing); lung: 53.1069% (minimum 75%, Missing); lymph node: 48.9687% (minimum 70%, Missing); midbrain: 56.0315% (minimum 75%, Missing); pancreas: 50.5521% (minimum 75%, Missing); parathyroid gland: 52.0292% (minimum 70%, Missing); pituitary gland: 65.7436% (minimum 75%, Missing); rectum: 51.9449% (minimum 70%, Missing); retina: 58.3789% (minimum 75%, Missing); salivary gland: 54.2760% (minimum 70%, Missing); skeletal muscle: 43.0490% (minimum 75%, Missing); skin: 50.8730% (minimum 65%, Missing); small intestine: 55.9825% (minimum 75%, Missing); smooth muscle: 47.5167% (minimum 75%, Missing); spinal cord: 64.1000% (minimum 75%, Missing); spleen: 55.9337% (minimum 65%, Missing); stomach: 54.1385% (minimum 70%, Missing); thymus: 51.9870% (minimum 65%, Missing); thyroid gland: 56.9778% (minimum 65%, Missing); tongue: 48.4505% (minimum 70%, Missing); urinary bladder: 49.5363% (minimum 70%, Missing)",-0.14127,-0.21913,-0.31951,0,80,unavailable,84.8,69.2,61.9,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 3); tongue: 68.2 nTPM (protected, limit 3); colon: 67.1 nTPM (protected, limit 3); lymph node: 66.8 nTPM (protected, limit 3); urinary bladder: 65.3 nTPM (protected, limit 3); pancreas: 62.7 nTPM (vital, limit 1); skin: 61.9 nTPM (manageable, limit 5); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 3); thymus: 59.2 nTPM (manageable, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 3); adipose tissue: 59.1 nTPM (manageable, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 3); salivary gland: 54 nTPM (protected, limit 3); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); spleen: 50.5 nTPM (manageable, limit 5); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (manageable, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244687,UBE2V1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.0292% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 54.0928% (minimum 75%, Baseline (adaptation disabled)); amygdala: 51.1981% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.4605% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 55.8849% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 54.6928% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 45.0140% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 45.4288% (minimum 75%, Baseline (adaptation disabled)); colon: 48.8567% (minimum 70%, Baseline (adaptation disabled)); duodenum: 53.0190% (minimum 75%, Baseline (adaptation disabled)); esophagus: 48.0870% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 51.6103% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.6907% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.6851% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.4612% (minimum 75%, Baseline (adaptation disabled)); liver: 45.8184% (minimum 75%, Baseline (adaptation disabled)); lung: 53.1069% (minimum 75%, Baseline (adaptation disabled)); lymph node: 48.9687% (minimum 70%, Baseline (adaptation disabled)); midbrain: 56.0315% (minimum 75%, Baseline (adaptation disabled)); pancreas: 50.5521% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 52.0292% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 65.7436% (minimum 75%, Baseline (adaptation disabled)); rectum: 51.9449% (minimum 70%, Baseline (adaptation disabled)); retina: 58.3789% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 54.2760% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 43.0490% (minimum 75%, Baseline (adaptation disabled)); skin: 50.8730% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.9825% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 47.5167% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.1000% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.9337% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.1385% (minimum 70%, Baseline (adaptation disabled)); thymus: 51.9870% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.9778% (minimum 65%, Baseline (adaptation disabled)); tongue: 48.4505% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 49.5363% (minimum 70%, Baseline (adaptation disabled))",-0.14127,-0.21913,-0.31951,0,80,unavailable,84.8,69.2,61.9,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 3); tongue: 68.2 nTPM (protected, limit 3); colon: 67.1 nTPM (protected, limit 3); lymph node: 66.8 nTPM (protected, limit 3); urinary bladder: 65.3 nTPM (protected, limit 3); pancreas: 62.7 nTPM (vital, limit 1); skin: 61.9 nTPM (manageable, limit 5); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 3); thymus: 59.2 nTPM (manageable, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 3); adipose tissue: 59.1 nTPM (manageable, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 3); salivary gland: 54 nTPM (protected, limit 3); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); spleen: 50.5 nTPM (manageable, limit 5); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (manageable, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000244687,UBE2V1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5263% (minimum 95%, Missing); adrenal gland: 48.4940% (minimum 99%, Missing); amygdala: 58.1227% (minimum 99%, Missing); basal ganglia: 58.5455% (minimum 99%, Missing); bone marrow: 49.2355% (minimum 99%, Missing); cerebellum: 52.7869% (minimum 99%, Missing); cerebral cortex: 47.6331% (minimum 99%, Missing); choroid plexus: 64.9194% (minimum 99%, Missing); colon: 50.1558% (minimum 97%, Missing); duodenum: 52.1036% (minimum 99%, Missing); esophagus: 41.0714% (minimum 97%, Missing); heart muscle: 45.3521% (minimum 99%, Missing); hippocampal formation: 52.7869% (minimum 99%, Missing); hypothalamus: 57.5000% (minimum 99%, Missing); kidney: 53.8462% (minimum 99%, Missing); liver: 36.3431% (minimum 99%, Missing); lung: 64.1434% (minimum 99%, Missing); lymph node: 43.5135% (minimum 97%, Missing); midbrain: 62.4031% (minimum 99%, Missing); pancreas: 39.0777% (minimum 99%, Missing); parathyroid gland: 61.2167% (minimum 80%, Enhanced); pituitary gland: 62.6459% (minimum 99%, Missing); rectum: 58.9744% (minimum 97%, Missing); retina: 73.5160% (minimum 99%, Missing); salivary gland: 51.1111% (minimum 97%, Missing); skeletal muscle: 33.4719% (minimum 95%, Enhanced); skin: 47.9167% (minimum 95%, Missing); small intestine: 55.7093% (minimum 99%, Missing); smooth muscle: 60.2996% (minimum 99%, Missing); spinal cord: 67.6471% (minimum 99%, Missing); spleen: 55.7093% (minimum 95%, Missing); stomach: 54.7619% (minimum 97%, Missing); thymus: 53.3113% (minimum 95%, Missing); thyroid gland: 58.9744% (minimum 95%, Missing); tongue: 47.0760% (minimum 97%, Missing); urinary bladder: 51.7685% (minimum 97%, Missing)",-0.470833,-0.559286,-0.626569,0,4,partial,32,23.1,17.5,"skeletal muscle: 32 nTPM (vital, limit 6); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 2); lymph node: 20.9 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 2); cerebral cortex: 17.7 nTPM (vital, limit 1); skin: 17.5 nTPM (manageable, limit 5); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); colon: 16 nTPM (protected, limit 2); salivary gland: 15.4 nTPM (protected, limit 2); urinary bladder: 15 nTPM (protected, limit 2); duodenum: 14.8 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); thymus: 14.1 nTPM (manageable, limit 5); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); small intestine: 12.8 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); rectum: 11.2 nTPM (protected, limit 2); thyroid gland: 11.2 nTPM (manageable, limit 5); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (manageable, limit 5); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000247077,PGAM5,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5263% (minimum 65%, Missing); adrenal gland: 48.4940% (minimum 75%, Missing); amygdala: 58.1227% (minimum 75%, Missing); basal ganglia: 58.5455% (minimum 75%, Missing); bone marrow: 49.2355% (minimum 75%, Missing); cerebellum: 52.7869% (minimum 75%, Missing); cerebral cortex: 47.6331% (minimum 75%, Missing); choroid plexus: 64.9194% (minimum 75%, Missing); colon: 50.1558% (minimum 70%, Missing); duodenum: 52.1036% (minimum 75%, Missing); esophagus: 41.0714% (minimum 70%, Missing); heart muscle: 45.3521% (minimum 75%, Missing); hippocampal formation: 52.7869% (minimum 75%, Missing); hypothalamus: 57.5000% (minimum 75%, Missing); kidney: 53.8462% (minimum 75%, Missing); liver: 36.3431% (minimum 75%, Missing); lung: 64.1434% (minimum 75%, Missing); lymph node: 43.5135% (minimum 70%, Missing); midbrain: 62.4031% (minimum 75%, Missing); pancreas: 39.0777% (minimum 75%, Missing); pituitary gland: 62.6459% (minimum 75%, Missing); rectum: 58.9744% (minimum 70%, Missing); retina: 73.5160% (minimum 75%, Missing); salivary gland: 51.1111% (minimum 70%, Missing); skeletal muscle: 33.4719% (minimum 60%, Enhanced); skin: 47.9167% (minimum 65%, Missing); small intestine: 55.7093% (minimum 75%, Missing); smooth muscle: 60.2996% (minimum 75%, Missing); spinal cord: 67.6471% (minimum 75%, Missing); spleen: 55.7093% (minimum 65%, Missing); stomach: 54.7619% (minimum 70%, Missing); thymus: 53.3113% (minimum 65%, Missing); thyroid gland: 58.9744% (minimum 65%, Missing); tongue: 47.0760% (minimum 70%, Missing); urinary bladder: 51.7685% (minimum 70%, Missing)",-0.170833,-0.289286,-0.386569,0,4,partial,32,23.1,17.5,"skeletal muscle: 32 nTPM (vital, limit 6); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 2); lymph node: 20.9 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 2); cerebral cortex: 17.7 nTPM (vital, limit 1); skin: 17.5 nTPM (manageable, limit 5); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); colon: 16 nTPM (protected, limit 2); salivary gland: 15.4 nTPM (protected, limit 2); urinary bladder: 15 nTPM (protected, limit 2); duodenum: 14.8 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); thymus: 14.1 nTPM (manageable, limit 5); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); small intestine: 12.8 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); rectum: 11.2 nTPM (protected, limit 2); thyroid gland: 11.2 nTPM (manageable, limit 5); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (manageable, limit 5); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000247077,PGAM5,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5263% (minimum 65%, Missing); adrenal gland: 48.4940% (minimum 75%, Missing); amygdala: 58.1227% (minimum 75%, Missing); basal ganglia: 58.5455% (minimum 75%, Missing); bone marrow: 49.2355% (minimum 75%, Missing); cerebellum: 52.7869% (minimum 75%, Missing); cerebral cortex: 47.6331% (minimum 75%, Missing); choroid plexus: 64.9194% (minimum 75%, Missing); colon: 50.1558% (minimum 70%, Missing); duodenum: 52.1036% (minimum 75%, Missing); esophagus: 41.0714% (minimum 70%, Missing); heart muscle: 45.3521% (minimum 75%, Missing); hippocampal formation: 52.7869% (minimum 75%, Missing); hypothalamus: 57.5000% (minimum 75%, Missing); kidney: 53.8462% (minimum 75%, Missing); liver: 36.3431% (minimum 75%, Missing); lung: 64.1434% (minimum 75%, Missing); lymph node: 43.5135% (minimum 70%, Missing); midbrain: 62.4031% (minimum 75%, Missing); pancreas: 39.0777% (minimum 75%, Missing); pituitary gland: 62.6459% (minimum 75%, Missing); rectum: 58.9744% (minimum 70%, Missing); retina: 73.5160% (minimum 75%, Missing); salivary gland: 51.1111% (minimum 70%, Missing); skeletal muscle: 33.4719% (minimum 60%, Enhanced); skin: 47.9167% (minimum 65%, Missing); small intestine: 55.7093% (minimum 75%, Missing); smooth muscle: 60.2996% (minimum 75%, Missing); spinal cord: 67.6471% (minimum 75%, Missing); spleen: 55.7093% (minimum 65%, Missing); stomach: 54.7619% (minimum 70%, Missing); thymus: 53.3113% (minimum 65%, Missing); thyroid gland: 58.9744% (minimum 65%, Missing); tongue: 47.0760% (minimum 70%, Missing); urinary bladder: 51.7685% (minimum 70%, Missing)",-0.170833,-0.289286,-0.386569,0,4,partial,32,23.1,17.5,"skeletal muscle: 32 nTPM (vital, limit 6); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 3); lymph node: 20.9 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 3); cerebral cortex: 17.7 nTPM (vital, limit 1); skin: 17.5 nTPM (manageable, limit 5); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); colon: 16 nTPM (protected, limit 3); salivary gland: 15.4 nTPM (protected, limit 3); urinary bladder: 15 nTPM (protected, limit 3); duodenum: 14.8 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); thymus: 14.1 nTPM (manageable, limit 5); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); small intestine: 12.8 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); rectum: 11.2 nTPM (protected, limit 3); thyroid gland: 11.2 nTPM (manageable, limit 5); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (manageable, limit 5); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000247077,PGAM5,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5263% (minimum 65%, Missing); adrenal gland: 48.4940% (minimum 75%, Missing); amygdala: 58.1227% (minimum 75%, Missing); basal ganglia: 58.5455% (minimum 75%, Missing); bone marrow: 49.2355% (minimum 75%, Missing); cerebellum: 52.7869% (minimum 75%, Missing); cerebral cortex: 47.6331% (minimum 75%, Missing); choroid plexus: 64.9194% (minimum 75%, Missing); colon: 50.1558% (minimum 70%, Missing); duodenum: 52.1036% (minimum 75%, Missing); esophagus: 41.0714% (minimum 70%, Missing); heart muscle: 45.3521% (minimum 75%, Missing); hippocampal formation: 52.7869% (minimum 75%, Missing); hypothalamus: 57.5000% (minimum 75%, Missing); kidney: 53.8462% (minimum 75%, Missing); liver: 36.3431% (minimum 75%, Missing); lung: 64.1434% (minimum 75%, Missing); lymph node: 43.5135% (minimum 70%, Missing); midbrain: 62.4031% (minimum 75%, Missing); pancreas: 39.0777% (minimum 75%, Missing); pituitary gland: 62.6459% (minimum 75%, Missing); rectum: 58.9744% (minimum 70%, Missing); retina: 73.5160% (minimum 75%, Missing); salivary gland: 51.1111% (minimum 70%, Missing); skeletal muscle: 33.4719% (minimum 60%, Enhanced); skin: 47.9167% (minimum 65%, Missing); small intestine: 55.7093% (minimum 75%, Missing); smooth muscle: 60.2996% (minimum 75%, Missing); spinal cord: 67.6471% (minimum 75%, Missing); spleen: 55.7093% (minimum 65%, Missing); stomach: 54.7619% (minimum 70%, Missing); thymus: 53.3113% (minimum 65%, Missing); thyroid gland: 58.9744% (minimum 65%, Missing); tongue: 47.0760% (minimum 70%, Missing); urinary bladder: 51.7685% (minimum 70%, Missing)",-0.170833,-0.289286,-0.386569,0,4,partial,32,23.1,17.5,"skeletal muscle: 32 nTPM (vital, limit 6); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 3); lymph node: 20.9 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 3); cerebral cortex: 17.7 nTPM (vital, limit 1); skin: 17.5 nTPM (manageable, limit 5); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); colon: 16 nTPM (protected, limit 3); salivary gland: 15.4 nTPM (protected, limit 3); urinary bladder: 15 nTPM (protected, limit 3); duodenum: 14.8 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); thymus: 14.1 nTPM (manageable, limit 5); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); small intestine: 12.8 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); rectum: 11.2 nTPM (protected, limit 3); thyroid gland: 11.2 nTPM (manageable, limit 5); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (manageable, limit 5); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000247077,PGAM5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5263% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 48.4940% (minimum 75%, Baseline (adaptation disabled)); amygdala: 58.1227% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.5455% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 49.2355% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 52.7869% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 47.6331% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.9194% (minimum 75%, Baseline (adaptation disabled)); colon: 50.1558% (minimum 70%, Baseline (adaptation disabled)); duodenum: 52.1036% (minimum 75%, Baseline (adaptation disabled)); esophagus: 41.0714% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 45.3521% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 52.7869% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 57.5000% (minimum 75%, Baseline (adaptation disabled)); kidney: 53.8462% (minimum 75%, Baseline (adaptation disabled)); liver: 36.3431% (minimum 75%, Baseline (adaptation disabled)); lung: 64.1434% (minimum 75%, Baseline (adaptation disabled)); lymph node: 43.5135% (minimum 70%, Baseline (adaptation disabled)); midbrain: 62.4031% (minimum 75%, Baseline (adaptation disabled)); pancreas: 39.0777% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 61.2167% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.6459% (minimum 75%, Baseline (adaptation disabled)); rectum: 58.9744% (minimum 70%, Baseline (adaptation disabled)); retina: 73.5160% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 51.1111% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 33.4719% (minimum 75%, Baseline (adaptation disabled)); skin: 47.9167% (minimum 65%, Baseline (adaptation disabled)); small intestine: 55.7093% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.2996% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 67.6471% (minimum 75%, Baseline (adaptation disabled)); spleen: 55.7093% (minimum 65%, Baseline (adaptation disabled)); stomach: 54.7619% (minimum 70%, Baseline (adaptation disabled)); thymus: 53.3113% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.9744% (minimum 65%, Baseline (adaptation disabled)); tongue: 47.0760% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 51.7685% (minimum 70%, Baseline (adaptation disabled))",-0.170833,-0.289286,-0.415281,0,4,partial,32,23.1,17.5,"skeletal muscle: 32 nTPM (vital, limit 1); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 3); lymph node: 20.9 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 3); cerebral cortex: 17.7 nTPM (vital, limit 1); skin: 17.5 nTPM (manageable, limit 5); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); colon: 16 nTPM (protected, limit 3); salivary gland: 15.4 nTPM (protected, limit 3); urinary bladder: 15 nTPM (protected, limit 3); duodenum: 14.8 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); thymus: 14.1 nTPM (manageable, limit 5); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); spleen: 12.8 nTPM (manageable, limit 5); small intestine: 12.8 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); rectum: 11.2 nTPM (protected, limit 3); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (manageable, limit 5); parathyroid gland: 10.2 nTPM (protected, limit 3); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000247077,PGAM5,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.1520% (minimum 99%, Missing); amygdala: 96.9880% (minimum 99%, Missing); basal ganglia: 96.2151% (minimum 99%, Missing); bone marrow: 98.9754% (minimum 99%, Missing); cerebellum: 96.7936% (minimum 99%, Missing); cerebral cortex: 94.8919% (minimum 99%, Missing); choroid plexus: 95.8333% (minimum 99%, Missing); heart muscle: 96.0239% (minimum 99%, Missing); hippocampal formation: 97.1831% (minimum 99%, Missing); hypothalamus: 95.2663% (minimum 99%, Missing); kidney: 93.2432% (minimum 99%, Missing); liver: 97.7733% (minimum 99%, Uncertain); lung: 96.9880% (minimum 99%, Missing); midbrain: 97.3790% (minimum 99%, Missing); pancreas: 97.7733% (minimum 99%, Missing); parathyroid gland: 89.9441% (minimum 97%, Missing); pituitary gland: 97.1831% (minimum 99%, Missing); retina: 94.1520% (minimum 99%, Missing); small intestine: 98.5714% (minimum 99%, Missing); smooth muscle: 96.4072% (minimum 99%, Uncertain); spinal cord: 97.5758% (minimum 99%, Missing); thyroid gland: 90.4494% (minimum 95%, Missing)",-0.0455056,-0.0705587,-0.0575676,0,6,partial,3.5,5.4,5.1,"parathyroid gland: 5.4 nTPM (protected, limit 2); thyroid gland: 5.1 nTPM (manageable, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000247746,USP51,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.254494,0.199441,0.182432,0,6,partial,3.5,5.4,5.1,"parathyroid gland: 5.4 nTPM (protected, limit 2); thyroid gland: 5.1 nTPM (manageable, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000247746,USP51,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.254494,0.199441,0.182432,0,6,partial,3.5,5.4,5.1,"parathyroid gland: 5.4 nTPM (protected, limit 3); thyroid gland: 5.1 nTPM (manageable, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000247746,USP51,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.254494,0.199441,0.182432,0,6,partial,3.5,5.4,5.1,"parathyroid gland: 5.4 nTPM (protected, limit 3); thyroid gland: 5.1 nTPM (manageable, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000247746,USP51,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.254494,0.199441,0.182432,0,6,partial,3.5,5.4,5.1,"parathyroid gland: 5.4 nTPM (protected, limit 3); thyroid gland: 5.1 nTPM (manageable, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000247746,USP51,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6614% (minimum 95%, Missing); adrenal gland: 28.9326% (minimum 99%, Missing); amygdala: 59.0822% (minimum 99%, Missing); basal ganglia: 57.0111% (minimum 99%, Missing); bone marrow: 49.1256% (minimum 99%, Missing); cerebellum: 61.5538% (minimum 99%, Missing); cerebral cortex: 55.0802% (minimum 99%, Missing); choroid plexus: 36.2251% (minimum 99%, Missing); colon: 60.3516% (minimum 97%, Missing); duodenum: 61.4314% (minimum 99%, Missing); esophagus: 32.8374% (minimum 97%, Missing); heart muscle: 26.0980% (minimum 99%, Missing); hippocampal formation: 62.8049% (minimum 99%, Missing); hypothalamus: 63.5802% (minimum 99%, Missing); kidney: 41.8133% (minimum 99%, Missing); liver: 22.3589% (minimum 99%, Missing); lung: 58.7452% (minimum 99%, Missing); lymph node: 56.3869% (minimum 97%, Missing); midbrain: 56.4899% (minimum 99%, Missing); pancreas: 40.8190% (minimum 99%, Missing); parathyroid gland: 36.2251% (minimum 97%, Missing); pituitary gland: 56.9061% (minimum 99%, Missing); rectum: 68.0617% (minimum 97%, Missing); retina: 59.5376% (minimum 99%, Missing); salivary gland: 43.7677% (minimum 97%, Missing); skeletal muscle: 22.5547% (minimum 99%, Missing); skin: 50.0000% (minimum 95%, Missing); small intestine: 62.9328% (minimum 99%, Missing); smooth muscle: 71.6937% (minimum 99%, Missing); spinal cord: 62.1730% (minimum 99%, Missing); spleen: 56.5934% (minimum 95%, Missing); stomach: 37.6829% (minimum 97%, Missing); thymus: 54.1156% (minimum 95%, Missing); thyroid gland: 43.3380% (minimum 95%, Missing); tongue: 20.8643% (minimum 97%, Missing); urinary bladder: 59.5376% (minimum 97%, Missing)",-0.51662,-0.761357,-0.766411,0,3,partial,107.3,117.2,40.4,"tongue: 117.2 nTPM (protected, limit 2); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 2); parathyroid gland: 54.4 nTPM (protected, limit 2); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 2); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (manageable, limit 5); salivary gland: 39.7 nTPM (protected, limit 2); adipose tissue: 32.6 nTPM (manageable, limit 5); bone marrow: 32 nTPM (vital, limit 1); skin: 30.9 nTPM (manageable, limit 5); thymus: 26.2 nTPM (manageable, limit 5); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 2); midbrain: 23.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 2); colon: 20.3 nTPM (protected, limit 2); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); rectum: 14.5 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248098,BCKDHA,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6614% (minimum 65%, Missing); adrenal gland: 28.9326% (minimum 75%, Missing); amygdala: 59.0822% (minimum 75%, Missing); basal ganglia: 57.0111% (minimum 75%, Missing); bone marrow: 49.1256% (minimum 75%, Missing); cerebellum: 61.5538% (minimum 75%, Missing); cerebral cortex: 55.0802% (minimum 75%, Missing); choroid plexus: 36.2251% (minimum 75%, Missing); colon: 60.3516% (minimum 70%, Missing); duodenum: 61.4314% (minimum 75%, Missing); esophagus: 32.8374% (minimum 70%, Missing); heart muscle: 26.0980% (minimum 75%, Missing); hippocampal formation: 62.8049% (minimum 75%, Missing); hypothalamus: 63.5802% (minimum 75%, Missing); kidney: 41.8133% (minimum 75%, Missing); liver: 22.3589% (minimum 75%, Missing); lung: 58.7452% (minimum 75%, Missing); lymph node: 56.3869% (minimum 70%, Missing); midbrain: 56.4899% (minimum 75%, Missing); pancreas: 40.8190% (minimum 75%, Missing); parathyroid gland: 36.2251% (minimum 70%, Missing); pituitary gland: 56.9061% (minimum 75%, Missing); rectum: 68.0617% (minimum 70%, Missing); retina: 59.5376% (minimum 75%, Missing); salivary gland: 43.7677% (minimum 70%, Missing); skeletal muscle: 22.5547% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 62.9328% (minimum 75%, Missing); smooth muscle: 71.6937% (minimum 75%, Missing); spinal cord: 62.1730% (minimum 75%, Missing); spleen: 56.5934% (minimum 65%, Missing); stomach: 37.6829% (minimum 70%, Missing); thymus: 54.1156% (minimum 65%, Missing); thyroid gland: 43.3380% (minimum 65%, Missing); tongue: 20.8643% (minimum 70%, Missing); urinary bladder: 59.5376% (minimum 70%, Missing)",-0.21662,-0.491357,-0.526411,0,3,partial,107.3,117.2,40.4,"tongue: 117.2 nTPM (protected, limit 2); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 2); parathyroid gland: 54.4 nTPM (protected, limit 2); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 2); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (manageable, limit 5); salivary gland: 39.7 nTPM (protected, limit 2); adipose tissue: 32.6 nTPM (manageable, limit 5); bone marrow: 32 nTPM (vital, limit 1); skin: 30.9 nTPM (manageable, limit 5); thymus: 26.2 nTPM (manageable, limit 5); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 2); midbrain: 23.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 2); colon: 20.3 nTPM (protected, limit 2); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); rectum: 14.5 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248098,BCKDHA,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6614% (minimum 65%, Missing); adrenal gland: 28.9326% (minimum 75%, Missing); amygdala: 59.0822% (minimum 75%, Missing); basal ganglia: 57.0111% (minimum 75%, Missing); bone marrow: 49.1256% (minimum 75%, Missing); cerebellum: 61.5538% (minimum 75%, Missing); cerebral cortex: 55.0802% (minimum 75%, Missing); choroid plexus: 36.2251% (minimum 75%, Missing); colon: 60.3516% (minimum 70%, Missing); duodenum: 61.4314% (minimum 75%, Missing); esophagus: 32.8374% (minimum 70%, Missing); heart muscle: 26.0980% (minimum 75%, Missing); hippocampal formation: 62.8049% (minimum 75%, Missing); hypothalamus: 63.5802% (minimum 75%, Missing); kidney: 41.8133% (minimum 75%, Missing); liver: 22.3589% (minimum 75%, Missing); lung: 58.7452% (minimum 75%, Missing); lymph node: 56.3869% (minimum 70%, Missing); midbrain: 56.4899% (minimum 75%, Missing); pancreas: 40.8190% (minimum 75%, Missing); parathyroid gland: 36.2251% (minimum 70%, Missing); pituitary gland: 56.9061% (minimum 75%, Missing); rectum: 68.0617% (minimum 70%, Missing); retina: 59.5376% (minimum 75%, Missing); salivary gland: 43.7677% (minimum 70%, Missing); skeletal muscle: 22.5547% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 62.9328% (minimum 75%, Missing); smooth muscle: 71.6937% (minimum 75%, Missing); spinal cord: 62.1730% (minimum 75%, Missing); spleen: 56.5934% (minimum 65%, Missing); stomach: 37.6829% (minimum 70%, Missing); thymus: 54.1156% (minimum 65%, Missing); thyroid gland: 43.3380% (minimum 65%, Missing); tongue: 20.8643% (minimum 70%, Missing); urinary bladder: 59.5376% (minimum 70%, Missing)",-0.21662,-0.491357,-0.526411,0,3,partial,107.3,117.2,40.4,"tongue: 117.2 nTPM (protected, limit 3); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 3); parathyroid gland: 54.4 nTPM (protected, limit 3); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 3); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (manageable, limit 5); salivary gland: 39.7 nTPM (protected, limit 3); adipose tissue: 32.6 nTPM (manageable, limit 5); bone marrow: 32 nTPM (vital, limit 1); skin: 30.9 nTPM (manageable, limit 5); thymus: 26.2 nTPM (manageable, limit 5); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 3); midbrain: 23.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 3); colon: 20.3 nTPM (protected, limit 3); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); rectum: 14.5 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248098,BCKDHA,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6614% (minimum 65%, Missing); adrenal gland: 28.9326% (minimum 75%, Missing); amygdala: 59.0822% (minimum 75%, Missing); basal ganglia: 57.0111% (minimum 75%, Missing); bone marrow: 49.1256% (minimum 75%, Missing); cerebellum: 61.5538% (minimum 75%, Missing); cerebral cortex: 55.0802% (minimum 75%, Missing); choroid plexus: 36.2251% (minimum 75%, Missing); colon: 60.3516% (minimum 70%, Missing); duodenum: 61.4314% (minimum 75%, Missing); esophagus: 32.8374% (minimum 70%, Missing); heart muscle: 26.0980% (minimum 75%, Missing); hippocampal formation: 62.8049% (minimum 75%, Missing); hypothalamus: 63.5802% (minimum 75%, Missing); kidney: 41.8133% (minimum 75%, Missing); liver: 22.3589% (minimum 75%, Missing); lung: 58.7452% (minimum 75%, Missing); lymph node: 56.3869% (minimum 70%, Missing); midbrain: 56.4899% (minimum 75%, Missing); pancreas: 40.8190% (minimum 75%, Missing); parathyroid gland: 36.2251% (minimum 70%, Missing); pituitary gland: 56.9061% (minimum 75%, Missing); rectum: 68.0617% (minimum 70%, Missing); retina: 59.5376% (minimum 75%, Missing); salivary gland: 43.7677% (minimum 70%, Missing); skeletal muscle: 22.5547% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 62.9328% (minimum 75%, Missing); smooth muscle: 71.6937% (minimum 75%, Missing); spinal cord: 62.1730% (minimum 75%, Missing); spleen: 56.5934% (minimum 65%, Missing); stomach: 37.6829% (minimum 70%, Missing); thymus: 54.1156% (minimum 65%, Missing); thyroid gland: 43.3380% (minimum 65%, Missing); tongue: 20.8643% (minimum 70%, Missing); urinary bladder: 59.5376% (minimum 70%, Missing)",-0.21662,-0.491357,-0.526411,0,3,partial,107.3,117.2,40.4,"tongue: 117.2 nTPM (protected, limit 3); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 3); parathyroid gland: 54.4 nTPM (protected, limit 3); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 3); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (manageable, limit 5); salivary gland: 39.7 nTPM (protected, limit 3); adipose tissue: 32.6 nTPM (manageable, limit 5); bone marrow: 32 nTPM (vital, limit 1); skin: 30.9 nTPM (manageable, limit 5); thymus: 26.2 nTPM (manageable, limit 5); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 3); midbrain: 23.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 3); colon: 20.3 nTPM (protected, limit 3); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); rectum: 14.5 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248098,BCKDHA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6614% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 28.9326% (minimum 75%, Baseline (adaptation disabled)); amygdala: 59.0822% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 57.0111% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 49.1256% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 61.5538% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 55.0802% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 36.2251% (minimum 75%, Baseline (adaptation disabled)); colon: 60.3516% (minimum 70%, Baseline (adaptation disabled)); duodenum: 61.4314% (minimum 75%, Baseline (adaptation disabled)); esophagus: 32.8374% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 26.0980% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 62.8049% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.5802% (minimum 75%, Baseline (adaptation disabled)); kidney: 41.8133% (minimum 75%, Baseline (adaptation disabled)); liver: 22.3589% (minimum 75%, Baseline (adaptation disabled)); lung: 58.7452% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.3869% (minimum 70%, Baseline (adaptation disabled)); midbrain: 56.4899% (minimum 75%, Baseline (adaptation disabled)); pancreas: 40.8190% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 36.2251% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 56.9061% (minimum 75%, Baseline (adaptation disabled)); rectum: 68.0617% (minimum 70%, Baseline (adaptation disabled)); retina: 59.5376% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 43.7677% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 22.5547% (minimum 75%, Baseline (adaptation disabled)); skin: 50.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 62.9328% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 71.6937% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 62.1730% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.5934% (minimum 65%, Baseline (adaptation disabled)); stomach: 37.6829% (minimum 70%, Baseline (adaptation disabled)); thymus: 54.1156% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 43.3380% (minimum 65%, Baseline (adaptation disabled)); tongue: 20.8643% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 59.5376% (minimum 70%, Baseline (adaptation disabled))",-0.21662,-0.491357,-0.526411,0,3,partial,107.3,117.2,40.4,"tongue: 117.2 nTPM (protected, limit 3); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 3); parathyroid gland: 54.4 nTPM (protected, limit 3); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 3); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (manageable, limit 5); salivary gland: 39.7 nTPM (protected, limit 3); adipose tissue: 32.6 nTPM (manageable, limit 5); bone marrow: 32 nTPM (vital, limit 1); skin: 30.9 nTPM (manageable, limit 5); thymus: 26.2 nTPM (manageable, limit 5); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 3); midbrain: 23.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 3); colon: 20.3 nTPM (protected, limit 3); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); rectum: 14.5 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248098,BCKDHA,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.0489937,0.0289937,0.00824032,0,2,partial,1.8,2.8,5.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248099,INSL3,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348994,0.298994,0.24824,0,2,partial,1.8,2.8,5.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248099,INSL3,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348994,0.298994,0.24824,0,2,partial,1.8,2.8,5.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248099,INSL3,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.348994,0.298994,0.24824,0,2,partial,1.8,2.8,5.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248099,INSL3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33732,0.292998,0.245488,0,2,partial,1.8,2.8,5.1,"spleen: 5.1 nTPM (manageable, limit 5); bone marrow: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248099,INSL3,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 95%, Missing); adrenal gland: 63.6364% (minimum 99%, Missing); amygdala: 63.6364% (minimum 99%, Missing); basal ganglia: 70.0000% (minimum 99%, Missing); cerebellum: 53.8462% (minimum 99%, Missing); cerebral cortex: 41.1765% (minimum 99%, Missing); choroid plexus: 87.5000% (minimum 99%, Missing); colon: 87.5000% (minimum 97%, Missing); hippocampal formation: 63.6364% (minimum 99%, Missing); hypothalamus: 58.3333% (minimum 99%, Missing); kidney: 77.7778% (minimum 99%, Missing); liver: 87.5000% (minimum 99%, Missing); lung: 53.8462% (minimum 99%, Missing); lymph node: 36.8421% (minimum 97%, Missing); midbrain: 63.6364% (minimum 99%, Missing); pancreas: 38.8889% (minimum 99%, Missing); parathyroid gland: 2.3729% (minimum 97%, Missing); pituitary gland: 50.0000% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 63.6364% (minimum 97%, Missing); smooth muscle: 77.7778% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 77.7778% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thyroid gland: 43.7500% (minimum 95%, Missing)",-0.5125,-0.946271,-0.601111,0,80,unavailable,1.1,28.8,0.9,"parathyroid gland: 28.8 nTPM (protected, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248383,PCDHAC1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 63.6364% (minimum 75%, Missing); basal ganglia: 70.0000% (minimum 75%, Missing); cerebellum: 53.8462% (minimum 75%, Missing); cerebral cortex: 41.1765% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); lung: 53.8462% (minimum 75%, Missing); lymph node: 36.8421% (minimum 70%, Missing); midbrain: 63.6364% (minimum 75%, Missing); pancreas: 38.8889% (minimum 75%, Missing); parathyroid gland: 2.3729% (minimum 70%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 63.6364% (minimum 70%, Missing); thyroid gland: 43.7500% (minimum 65%, Missing)",-0.2125,-0.676271,-0.361111,0,80,unavailable,1.1,28.8,0.9,"parathyroid gland: 28.8 nTPM (protected, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248383,PCDHAC1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 63.6364% (minimum 75%, Missing); basal ganglia: 70.0000% (minimum 75%, Missing); cerebellum: 53.8462% (minimum 75%, Missing); cerebral cortex: 41.1765% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); lung: 53.8462% (minimum 75%, Missing); lymph node: 36.8421% (minimum 70%, Missing); midbrain: 63.6364% (minimum 75%, Missing); pancreas: 38.8889% (minimum 75%, Missing); parathyroid gland: 2.3729% (minimum 70%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 63.6364% (minimum 70%, Missing); thyroid gland: 43.7500% (minimum 65%, Missing)",-0.2125,-0.676271,-0.361111,0,80,unavailable,1.1,28.8,0.9,"parathyroid gland: 28.8 nTPM (protected, limit 3); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248383,PCDHAC1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 63.6364% (minimum 75%, Missing); basal ganglia: 70.0000% (minimum 75%, Missing); cerebellum: 53.8462% (minimum 75%, Missing); cerebral cortex: 41.1765% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); lung: 53.8462% (minimum 75%, Missing); lymph node: 36.8421% (minimum 70%, Missing); midbrain: 63.6364% (minimum 75%, Missing); pancreas: 38.8889% (minimum 75%, Missing); parathyroid gland: 2.3729% (minimum 70%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 63.6364% (minimum 70%, Missing); thyroid gland: 43.7500% (minimum 65%, Missing)",-0.2125,-0.676271,-0.361111,0,80,unavailable,1.1,28.8,0.9,"parathyroid gland: 28.8 nTPM (protected, limit 3); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248383,PCDHAC1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.6364% (minimum 75%, Baseline (adaptation disabled)); amygdala: 63.6364% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 53.8462% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 41.1765% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.6364% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 58.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 53.8462% (minimum 75%, Baseline (adaptation disabled)); lymph node: 36.8421% (minimum 70%, Baseline (adaptation disabled)); midbrain: 63.6364% (minimum 75%, Baseline (adaptation disabled)); pancreas: 38.8889% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 2.3729% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.6364% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 43.7500% (minimum 65%, Baseline (adaptation disabled))",-0.2125,-0.676271,-0.361111,0,80,unavailable,1.1,28.8,0.9,"parathyroid gland: 28.8 nTPM (protected, limit 3); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248383,PCDHAC1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"bone marrow: 82.6087% (minimum 95%, Enhanced); cerebral cortex: 90.4762% (minimum 95%, Enhanced); colon: 95.0000% (minimum 97%, Missing); duodenum: 90.4762% (minimum 95%, Enhanced); kidney: 95.0000% (minimum 99%, Missing); retina: 65.5172% (minimum 99%, Missing); small intestine: 90.4762% (minimum 95%, Enhanced); tongue: 95.0000% (minimum 97%, Missing)",0,-0.02,-0.334828,0,4,partial,1,0.2,0.4,,kidney / cells in tubules: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248483,POU5F2,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"retina: 65.5172% (minimum 75%, Missing)",0.3,0.25,-0.0948276,0,4,partial,1,0.2,0.4,,kidney / cells in tubules: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248483,POU5F2,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"retina: 65.5172% (minimum 75%, Missing)",0.3,0.25,-0.0948276,0,4,partial,1,0.2,0.4,,kidney / cells in tubules: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248483,POU5F2,grid_revised,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"retina: 65.5172% (minimum 75%, Missing)",0.3,0.25,-0.0948276,0,4,partial,1,0.2,0.4,,kidney / cells in tubules: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248483,POU5F2,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"retina: 65.5172% (minimum 75%, Baseline (adaptation disabled))",0.176087,0.204762,-0.0948276,0,4,partial,1,0.2,0.4,,kidney / cells in tubules: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248483,POU5F2,current_fixed,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000248767,FOXL3,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000248767,FOXL3,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000248767,FOXL3,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000248767,FOXL3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000248767,FOXL3,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.3962% (minimum 99%, Missing); amygdala: 96.1165% (minimum 99%, Missing); basal ganglia: 98.0198% (minimum 99%, Missing); bone marrow: 89.1892% (minimum 97%, Supported); cerebral cortex: 81.8182% (minimum 97%, Supported); choroid plexus: 79.2000% (minimum 99%, Missing); colon: 64.2857% (minimum 97%, Missing); duodenum: 88.3929% (minimum 99%, Missing); esophagus: 83.8983% (minimum 97%, Missing); heart muscle: 92.5234% (minimum 99%, Missing); hippocampal formation: 95.1923% (minimum 99%, Missing); hypothalamus: 95.1923% (minimum 99%, Missing); kidney: 78.5714% (minimum 99%, Missing); liver: 96.1165% (minimum 97%, Supported); lung: 75.0000% (minimum 99%, Missing); midbrain: 93.3962% (minimum 99%, Missing); pancreas: 89.1892% (minimum 99%, Missing); parathyroid gland: 87.6106% (minimum 97%, Missing); pituitary gland: 73.3333% (minimum 99%, Missing); rectum: 70.2128% (minimum 97%, Missing); retina: 25.3846% (minimum 99%, Missing); salivary gland: 70.7143% (minimum 97%, Missing); skeletal muscle: 93.3962% (minimum 99%, Missing); skin: 71.2230% (minimum 95%, Missing); small intestine: 84.6154% (minimum 99%, Missing); smooth muscle: 82.5000% (minimum 99%, Missing); spinal cord: 86.8421% (minimum 99%, Missing); stomach: 56.2500% (minimum 97%, Missing); thymus: 72.7941% (minimum 95%, Missing); thyroid gland: 79.8387% (minimum 80%, Supported); tongue: 95.1923% (minimum 97%, Missing); urinary bladder: 88.3929% (minimum 97%, Missing)",-0.23777,-0.4075,-0.736154,0,13,partial,29.1,7.7,4,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); colon: 5.5 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); salivary gland: 4.1 nTPM (protected, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / langerhans cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in corneal layer: Low (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: High (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248905,FMN1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 64.2857% (minimum 70%, Missing); pituitary gland: 73.3333% (minimum 75%, Missing); retina: 25.3846% (minimum 75%, Missing); stomach: 56.2500% (minimum 70%, Missing)",0.0622302,-0.1375,-0.496154,0,13,partial,29.1,7.7,4,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); colon: 5.5 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); salivary gland: 4.1 nTPM (protected, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / langerhans cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in corneal layer: Low (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: High (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248905,FMN1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 64.2857% (minimum 70%, Missing); pituitary gland: 73.3333% (minimum 75%, Missing); retina: 25.3846% (minimum 75%, Missing); stomach: 56.2500% (minimum 70%, Missing)",0.0622302,-0.1375,-0.496154,0,13,partial,29.1,7.7,4,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); colon: 5.5 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); salivary gland: 4.1 nTPM (protected, limit 3); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / langerhans cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in corneal layer: Low (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: High (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248905,FMN1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 64.2857% (minimum 70%, Missing); pituitary gland: 73.3333% (minimum 75%, Missing); retina: 25.3846% (minimum 75%, Missing); stomach: 56.2500% (minimum 70%, Missing)",0.0622302,-0.1375,-0.496154,0,13,partial,29.1,7.7,4,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); colon: 5.5 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); salivary gland: 4.1 nTPM (protected, limit 3); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / langerhans cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in corneal layer: Low (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: High (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248905,FMN1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 64.2857% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 73.3333% (minimum 75%, Baseline (adaptation disabled)); retina: 25.3846% (minimum 75%, Baseline (adaptation disabled)); stomach: 56.2500% (minimum 70%, Baseline (adaptation disabled))",0.0622302,-0.1375,-0.496154,0,13,partial,29.1,7.7,4,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); colon: 5.5 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); salivary gland: 4.1 nTPM (protected, limit 3); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / langerhans cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in corneal layer: Low (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: High (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000248905,FMN1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,1,partial,0.1,0,0.1,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249139,EPPIN-WFDC6,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0.1,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249139,EPPIN-WFDC6,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0.1,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249139,EPPIN-WFDC6,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0.1,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249139,EPPIN-WFDC6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.348397,0.3,0.248397,0,1,partial,0.1,0,0.1,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249139,EPPIN-WFDC6,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.9286% (minimum 95%, Missing); adrenal gland: 61.1111% (minimum 99%, Missing); amygdala: 66.0000% (minimum 99%, Missing); basal ganglia: 62.2642% (minimum 99%, Missing); bone marrow: 66.0000% (minimum 99%, Missing); cerebellum: 55.0000% (minimum 99%, Missing); cerebral cortex: 52.3810% (minimum 99%, Missing); choroid plexus: 68.7500% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 64.7059% (minimum 99%, Missing); esophagus: 53.2258% (minimum 97%, Missing); heart muscle: 66.0000% (minimum 99%, Missing); hippocampal formation: 64.7059% (minimum 99%, Missing); hypothalamus: 66.0000% (minimum 99%, Missing); kidney: 60.0000% (minimum 99%, Missing); liver: 57.8947% (minimum 99%, Missing); lung: 60.0000% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 71.7391% (minimum 99%, Missing); pancreas: 48.5294% (minimum 99%, Missing); parathyroid gland: 56.8966% (minimum 97%, Missing); pituitary gland: 52.3810% (minimum 99%, Missing); rectum: 66.0000% (minimum 97%, Missing); retina: 64.7059% (minimum 99%, Missing); salivary gland: 55.9322% (minimum 97%, Missing); skeletal muscle: 52.3810% (minimum 99%, Missing); skin: 47.1429% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 61.1111% (minimum 99%, Missing); spinal cord: 73.3333% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 55.9322% (minimum 97%, Missing); thymus: 56.8966% (minimum 95%, Missing); thyroid gland: 55.0000% (minimum 95%, Missing); tongue: 67.3469% (minimum 97%, Missing); urinary bladder: 53.2258% (minimum 97%, Missing)",-0.478571,-0.437742,-0.504706,0,80,unavailable,3.5,2.9,3.7,"pancreas: 3.5 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.5 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249471,ZNF324B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.9286% (minimum 65%, Missing); adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 66.0000% (minimum 75%, Missing); basal ganglia: 62.2642% (minimum 75%, Missing); bone marrow: 66.0000% (minimum 75%, Missing); cerebellum: 55.0000% (minimum 75%, Missing); cerebral cortex: 52.3810% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 64.7059% (minimum 75%, Missing); esophagus: 53.2258% (minimum 70%, Missing); heart muscle: 66.0000% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); hypothalamus: 66.0000% (minimum 75%, Missing); kidney: 60.0000% (minimum 75%, Missing); liver: 57.8947% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); midbrain: 71.7391% (minimum 75%, Missing); pancreas: 48.5294% (minimum 75%, Missing); parathyroid gland: 56.8966% (minimum 70%, Missing); pituitary gland: 52.3810% (minimum 75%, Missing); rectum: 66.0000% (minimum 70%, Missing); retina: 64.7059% (minimum 75%, Missing); salivary gland: 55.9322% (minimum 70%, Missing); skeletal muscle: 52.3810% (minimum 75%, Missing); skin: 47.1429% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 61.1111% (minimum 75%, Missing); spinal cord: 73.3333% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 55.9322% (minimum 70%, Missing); thymus: 56.8966% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); tongue: 67.3469% (minimum 70%, Missing); urinary bladder: 53.2258% (minimum 70%, Missing)",-0.178571,-0.167742,-0.264706,0,80,unavailable,3.5,2.9,3.7,"pancreas: 3.5 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.5 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249471,ZNF324B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.9286% (minimum 65%, Missing); adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 66.0000% (minimum 75%, Missing); basal ganglia: 62.2642% (minimum 75%, Missing); bone marrow: 66.0000% (minimum 75%, Missing); cerebellum: 55.0000% (minimum 75%, Missing); cerebral cortex: 52.3810% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 64.7059% (minimum 75%, Missing); esophagus: 53.2258% (minimum 70%, Missing); heart muscle: 66.0000% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); hypothalamus: 66.0000% (minimum 75%, Missing); kidney: 60.0000% (minimum 75%, Missing); liver: 57.8947% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); midbrain: 71.7391% (minimum 75%, Missing); pancreas: 48.5294% (minimum 75%, Missing); parathyroid gland: 56.8966% (minimum 70%, Missing); pituitary gland: 52.3810% (minimum 75%, Missing); rectum: 66.0000% (minimum 70%, Missing); retina: 64.7059% (minimum 75%, Missing); salivary gland: 55.9322% (minimum 70%, Missing); skeletal muscle: 52.3810% (minimum 75%, Missing); skin: 47.1429% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 61.1111% (minimum 75%, Missing); spinal cord: 73.3333% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 55.9322% (minimum 70%, Missing); thymus: 56.8966% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); tongue: 67.3469% (minimum 70%, Missing); urinary bladder: 53.2258% (minimum 70%, Missing)",-0.178571,-0.167742,-0.264706,0,80,unavailable,3.5,2.9,3.7,"pancreas: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249471,ZNF324B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.9286% (minimum 65%, Missing); adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 66.0000% (minimum 75%, Missing); basal ganglia: 62.2642% (minimum 75%, Missing); bone marrow: 66.0000% (minimum 75%, Missing); cerebellum: 55.0000% (minimum 75%, Missing); cerebral cortex: 52.3810% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 64.7059% (minimum 75%, Missing); esophagus: 53.2258% (minimum 70%, Missing); heart muscle: 66.0000% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); hypothalamus: 66.0000% (minimum 75%, Missing); kidney: 60.0000% (minimum 75%, Missing); liver: 57.8947% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); midbrain: 71.7391% (minimum 75%, Missing); pancreas: 48.5294% (minimum 75%, Missing); parathyroid gland: 56.8966% (minimum 70%, Missing); pituitary gland: 52.3810% (minimum 75%, Missing); rectum: 66.0000% (minimum 70%, Missing); retina: 64.7059% (minimum 75%, Missing); salivary gland: 55.9322% (minimum 70%, Missing); skeletal muscle: 52.3810% (minimum 75%, Missing); skin: 47.1429% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 61.1111% (minimum 75%, Missing); spinal cord: 73.3333% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 55.9322% (minimum 70%, Missing); thymus: 56.8966% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); tongue: 67.3469% (minimum 70%, Missing); urinary bladder: 53.2258% (minimum 70%, Missing)",-0.178571,-0.167742,-0.264706,0,80,unavailable,3.5,2.9,3.7,"pancreas: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249471,ZNF324B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.9286% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 61.1111% (minimum 75%, Baseline (adaptation disabled)); amygdala: 66.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 62.2642% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 55.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 52.3810% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.7500% (minimum 75%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.7059% (minimum 75%, Baseline (adaptation disabled)); esophagus: 53.2258% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 66.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.7059% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 66.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 57.8947% (minimum 75%, Baseline (adaptation disabled)); lung: 60.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 70%, Baseline (adaptation disabled)); midbrain: 71.7391% (minimum 75%, Baseline (adaptation disabled)); pancreas: 48.5294% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 56.8966% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 52.3810% (minimum 75%, Baseline (adaptation disabled)); rectum: 66.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 64.7059% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.9322% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 52.3810% (minimum 75%, Baseline (adaptation disabled)); skin: 47.1429% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 61.1111% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 73.3333% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.9322% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.8966% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 55.0000% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.3469% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 53.2258% (minimum 70%, Baseline (adaptation disabled))",-0.178571,-0.167742,-0.264706,0,80,unavailable,3.5,2.9,3.7,"pancreas: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249471,ZNF324B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.1651% (minimum 99%, Missing); basal ganglia: 97.2727% (minimum 99%, Missing); choroid plexus: 95.5357% (minimum 99%, Missing); hippocampal formation: 97.2727% (minimum 99%, Missing); hypothalamus: 97.2727% (minimum 99%, Missing); lung: 97.2727% (minimum 98%, Approved)",0.0453488,0.03,-0.0346429,0,4,partial,1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249481,SPATS1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345349,0.3,0.205357,0,4,partial,1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249481,SPATS1,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345349,0.3,0.205357,0,4,partial,1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249481,SPATS1,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345349,0.3,0.205357,0,4,partial,1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249481,SPATS1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.345349,0.295349,0.205357,0,4,partial,1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249481,SPATS1,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 50.0000% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing)",0.05,-0.47,-0.49,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249581,CLRN2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 50.0000% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing)",0.35,-0.2,-0.25,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249581,CLRN2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 50.0000% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing)",0.35,-0.2,-0.25,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249581,CLRN2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 50.0000% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing)",0.35,-0.2,-0.25,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249581,CLRN2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 50.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.2,-0.25,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249581,CLRN2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 91.8919% (minimum 99%, Missing); colon: 94.4444% (minimum 97%, Missing); skin: 91.8919% (minimum 95%, Missing); smooth muscle: 87.1795% (minimum 99%, Missing); urinary bladder: 94.4444% (minimum 97%, Missing)",-0.0310811,-0.0255556,-0.118205,0,80,unavailable,0.5,0.2,0.3,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249693,SPMAP2L,admission_only,True,False,False,False,10.1002/cam4.2223;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT
True,compatible,,True,True,True,,0.268919,0.244444,0.121795,0,80,unavailable,0.5,0.2,0.3,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249693,SPMAP2L,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT
True,compatible,,True,True,True,,0.268919,0.244444,0.121795,0,80,unavailable,0.5,0.2,0.3,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249693,SPMAP2L,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT
True,compatible,,True,True,True,,0.268919,0.244444,0.121795,0,80,unavailable,0.5,0.2,0.3,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249693,SPMAP2L,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT
True,compatible,,True,True,True,,0.268919,0.244444,0.121795,0,80,unavailable,0.5,0.2,0.3,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249693,SPMAP2L,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 95%, Missing); adrenal gland: 67.9245% (minimum 99%, Missing); amygdala: 75.7895% (minimum 99%, Missing); basal ganglia: 72.0000% (minimum 99%, Missing); bone marrow: 62.6087% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); cerebral cortex: 72.0000% (minimum 99%, Missing); choroid plexus: 64.2857% (minimum 99%, Missing); colon: 50.0000% (minimum 97%, Missing); duodenum: 54.1353% (minimum 99%, Missing); esophagus: 71.2871% (minimum 97%, Missing); heart muscle: 59.5041% (minimum 99%, Missing); hippocampal formation: 75.7895% (minimum 99%, Missing); hypothalamus: 79.1209% (minimum 99%, Missing); kidney: 49.3151% (minimum 99%, Missing); liver: 56.6929% (minimum 99%, Missing); lung: 63.7168% (minimum 99%, Missing); lymph node: 51.7986% (minimum 97%, Missing); midbrain: 78.2609% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 49.6552% (minimum 97%, Missing); pituitary gland: 69.9029% (minimum 99%, Missing); rectum: 50.7042% (minimum 97%, Missing); retina: 51.0638% (minimum 99%, Missing); salivary gland: 60.5042% (minimum 97%, Missing); skeletal muscle: 54.5455% (minimum 99%, Missing); skin: 58.0645% (minimum 95%, Missing); small intestine: 51.0638% (minimum 99%, Missing); smooth muscle: 63.1579% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 51.7986% (minimum 95%, Missing); stomach: 52.1739% (minimum 97%, Missing); thymus: 49.6552% (minimum 95%, Missing); thyroid gland: 48.3221% (minimum 95%, Missing); tongue: 48.3221% (minimum 97%, Missing); urinary bladder: 58.5366% (minimum 97%, Missing)",-0.466779,-0.486779,-0.496849,0,80,unavailable,7.4,7.7,7.7,"tongue: 7.7 nTPM (protected, limit 2); thyroid gland: 7.7 nTPM (manageable, limit 5); kidney: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); rectum: 7 nTPM (protected, limit 2); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lymph node: 6.7 nTPM (protected, limit 2); stomach: 6.6 nTPM (protected, limit 2); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 2); heart muscle: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249709,ZNF564,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 65%, Missing); adrenal gland: 67.9245% (minimum 75%, Missing); basal ganglia: 72.0000% (minimum 75%, Missing); bone marrow: 62.6087% (minimum 75%, Missing); cerebral cortex: 72.0000% (minimum 75%, Missing); choroid plexus: 64.2857% (minimum 75%, Missing); colon: 50.0000% (minimum 70%, Missing); duodenum: 54.1353% (minimum 75%, Missing); heart muscle: 59.5041% (minimum 75%, Missing); kidney: 49.3151% (minimum 75%, Missing); liver: 56.6929% (minimum 75%, Missing); lung: 63.7168% (minimum 75%, Missing); lymph node: 51.7986% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 49.6552% (minimum 70%, Missing); pituitary gland: 69.9029% (minimum 75%, Missing); rectum: 50.7042% (minimum 70%, Missing); retina: 51.0638% (minimum 75%, Missing); salivary gland: 60.5042% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 58.0645% (minimum 65%, Missing); small intestine: 51.0638% (minimum 75%, Missing); smooth muscle: 63.1579% (minimum 75%, Missing); spleen: 51.7986% (minimum 65%, Missing); stomach: 52.1739% (minimum 70%, Missing); thymus: 49.6552% (minimum 65%, Missing); thyroid gland: 48.3221% (minimum 65%, Missing); tongue: 48.3221% (minimum 70%, Missing); urinary bladder: 58.5366% (minimum 70%, Missing)",-0.166779,-0.216779,-0.256849,0,80,unavailable,7.4,7.7,7.7,"tongue: 7.7 nTPM (protected, limit 2); thyroid gland: 7.7 nTPM (manageable, limit 5); kidney: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); rectum: 7 nTPM (protected, limit 2); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lymph node: 6.7 nTPM (protected, limit 2); stomach: 6.6 nTPM (protected, limit 2); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 2); heart muscle: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249709,ZNF564,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 65%, Missing); adrenal gland: 67.9245% (minimum 75%, Missing); basal ganglia: 72.0000% (minimum 75%, Missing); bone marrow: 62.6087% (minimum 75%, Missing); cerebral cortex: 72.0000% (minimum 75%, Missing); choroid plexus: 64.2857% (minimum 75%, Missing); colon: 50.0000% (minimum 70%, Missing); duodenum: 54.1353% (minimum 75%, Missing); heart muscle: 59.5041% (minimum 75%, Missing); kidney: 49.3151% (minimum 75%, Missing); liver: 56.6929% (minimum 75%, Missing); lung: 63.7168% (minimum 75%, Missing); lymph node: 51.7986% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 49.6552% (minimum 70%, Missing); pituitary gland: 69.9029% (minimum 75%, Missing); rectum: 50.7042% (minimum 70%, Missing); retina: 51.0638% (minimum 75%, Missing); salivary gland: 60.5042% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 58.0645% (minimum 65%, Missing); small intestine: 51.0638% (minimum 75%, Missing); smooth muscle: 63.1579% (minimum 75%, Missing); spleen: 51.7986% (minimum 65%, Missing); stomach: 52.1739% (minimum 70%, Missing); thymus: 49.6552% (minimum 65%, Missing); thyroid gland: 48.3221% (minimum 65%, Missing); tongue: 48.3221% (minimum 70%, Missing); urinary bladder: 58.5366% (minimum 70%, Missing)",-0.166779,-0.216779,-0.256849,0,80,unavailable,7.4,7.7,7.7,"tongue: 7.7 nTPM (protected, limit 3); thyroid gland: 7.7 nTPM (manageable, limit 5); kidney: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); rectum: 7 nTPM (protected, limit 3); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lymph node: 6.7 nTPM (protected, limit 3); stomach: 6.6 nTPM (protected, limit 3); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 3); heart muscle: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 3); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249709,ZNF564,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 65%, Missing); adrenal gland: 67.9245% (minimum 75%, Missing); basal ganglia: 72.0000% (minimum 75%, Missing); bone marrow: 62.6087% (minimum 75%, Missing); cerebral cortex: 72.0000% (minimum 75%, Missing); choroid plexus: 64.2857% (minimum 75%, Missing); colon: 50.0000% (minimum 70%, Missing); duodenum: 54.1353% (minimum 75%, Missing); heart muscle: 59.5041% (minimum 75%, Missing); kidney: 49.3151% (minimum 75%, Missing); liver: 56.6929% (minimum 75%, Missing); lung: 63.7168% (minimum 75%, Missing); lymph node: 51.7986% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 49.6552% (minimum 70%, Missing); pituitary gland: 69.9029% (minimum 75%, Missing); rectum: 50.7042% (minimum 70%, Missing); retina: 51.0638% (minimum 75%, Missing); salivary gland: 60.5042% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 58.0645% (minimum 65%, Missing); small intestine: 51.0638% (minimum 75%, Missing); smooth muscle: 63.1579% (minimum 75%, Missing); spleen: 51.7986% (minimum 65%, Missing); stomach: 52.1739% (minimum 70%, Missing); thymus: 49.6552% (minimum 65%, Missing); thyroid gland: 48.3221% (minimum 65%, Missing); tongue: 48.3221% (minimum 70%, Missing); urinary bladder: 58.5366% (minimum 70%, Missing)",-0.166779,-0.216779,-0.256849,0,80,unavailable,7.4,7.7,7.7,"tongue: 7.7 nTPM (protected, limit 3); thyroid gland: 7.7 nTPM (manageable, limit 5); kidney: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); rectum: 7 nTPM (protected, limit 3); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lymph node: 6.7 nTPM (protected, limit 3); stomach: 6.6 nTPM (protected, limit 3); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 3); heart muscle: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 3); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249709,ZNF564,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 67.9245% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 72.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 62.6087% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 72.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 64.2857% (minimum 75%, Baseline (adaptation disabled)); colon: 50.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 54.1353% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 59.5041% (minimum 75%, Baseline (adaptation disabled)); kidney: 49.3151% (minimum 75%, Baseline (adaptation disabled)); liver: 56.6929% (minimum 75%, Baseline (adaptation disabled)); lung: 63.7168% (minimum 75%, Baseline (adaptation disabled)); lymph node: 51.7986% (minimum 70%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 49.6552% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.9029% (minimum 75%, Baseline (adaptation disabled)); rectum: 50.7042% (minimum 70%, Baseline (adaptation disabled)); retina: 51.0638% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.5042% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 54.5455% (minimum 75%, Baseline (adaptation disabled)); skin: 58.0645% (minimum 65%, Baseline (adaptation disabled)); small intestine: 51.0638% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 63.1579% (minimum 75%, Baseline (adaptation disabled)); spleen: 51.7986% (minimum 65%, Baseline (adaptation disabled)); stomach: 52.1739% (minimum 70%, Baseline (adaptation disabled)); thymus: 49.6552% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 48.3221% (minimum 65%, Baseline (adaptation disabled)); tongue: 48.3221% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.5366% (minimum 70%, Baseline (adaptation disabled))",-0.166779,-0.216779,-0.256849,0,80,unavailable,7.4,7.7,7.7,"tongue: 7.7 nTPM (protected, limit 3); thyroid gland: 7.7 nTPM (manageable, limit 5); kidney: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); rectum: 7 nTPM (protected, limit 3); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lymph node: 6.7 nTPM (protected, limit 3); stomach: 6.6 nTPM (protected, limit 3); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 3); heart muscle: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 3); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249709,ZNF564,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 93.3333% (minimum 99%, Missing); cerebral cortex: 98.2456% (minimum 99%, Missing); hypothalamus: 96.5517% (minimum 99%, Missing); midbrain: 98.2456% (minimum 99%, Missing); retina: 93.3333% (minimum 99%, Missing)",0.05,0.03,-0.0566667,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249861,LGALS16,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.183333,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249861,LGALS16,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.183333,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249861,LGALS16,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.183333,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249861,LGALS16,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.35,0.3,0.183333,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249861,LGALS16,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 85.7143% (minimum 99%, Missing); amygdala: 57.1429% (minimum 99%, Missing); basal ganglia: 48.0000% (minimum 99%, Missing); bone marrow: 22.6415% (minimum 99%, Missing); cerebellum: 70.5882% (minimum 99%, Missing); cerebral cortex: 33.3333% (minimum 99%, Missing); colon: 70.5882% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 63.1579% (minimum 97%, Missing); heart muscle: 23.0769% (minimum 99%, Missing); hippocampal formation: 60.0000% (minimum 99%, Missing); hypothalamus: 63.1579% (minimum 99%, Missing); kidney: 85.7143% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lung: 85.7143% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 70.5882% (minimum 99%, Missing); pancreas: 92.3077% (minimum 99%, Missing); parathyroid gland: 80.0000% (minimum 97%, Missing); pituitary gland: 85.7143% (minimum 99%, Missing); rectum: 80.0000% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); salivary gland: 92.3077% (minimum 97%, Missing); skeletal muscle: 36.3636% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 57.1429% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 85.7143% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 92.3077% (minimum 97%, Missing)",-0.283333,-0.398571,-0.763585,0,80,unavailable,4.1,0.9,0.6,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249884,RNF103-CHMP3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 57.1429% (minimum 75%, Missing); basal ganglia: 48.0000% (minimum 75%, Missing); bone marrow: 22.6415% (minimum 75%, Missing); cerebellum: 70.5882% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 63.1579% (minimum 70%, Missing); heart muscle: 23.0769% (minimum 75%, Missing); hippocampal formation: 60.0000% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); midbrain: 70.5882% (minimum 75%, Missing); retina: 75.0000% (minimum 75%, Missing); skeletal muscle: 36.3636% (minimum 75%, Missing); stomach: 57.1429% (minimum 70%, Missing)",0.0166667,-0.128571,-0.523585,0,80,unavailable,4.1,0.9,0.6,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249884,RNF103-CHMP3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 57.1429% (minimum 75%, Missing); basal ganglia: 48.0000% (minimum 75%, Missing); bone marrow: 22.6415% (minimum 75%, Missing); cerebellum: 70.5882% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 63.1579% (minimum 70%, Missing); heart muscle: 23.0769% (minimum 75%, Missing); hippocampal formation: 60.0000% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); midbrain: 70.5882% (minimum 75%, Missing); retina: 75.0000% (minimum 75%, Missing); skeletal muscle: 36.3636% (minimum 75%, Missing); stomach: 57.1429% (minimum 70%, Missing)",0.0166667,-0.128571,-0.523585,0,80,unavailable,4.1,0.9,0.6,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249884,RNF103-CHMP3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 57.1429% (minimum 75%, Missing); basal ganglia: 48.0000% (minimum 75%, Missing); bone marrow: 22.6415% (minimum 75%, Missing); cerebellum: 70.5882% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 63.1579% (minimum 70%, Missing); heart muscle: 23.0769% (minimum 75%, Missing); hippocampal formation: 60.0000% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); midbrain: 70.5882% (minimum 75%, Missing); retina: 75.0000% (minimum 75%, Missing); skeletal muscle: 36.3636% (minimum 75%, Missing); stomach: 57.1429% (minimum 70%, Missing)",0.0166667,-0.128571,-0.523585,0,80,unavailable,4.1,0.9,0.6,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249884,RNF103-CHMP3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 57.1429% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 48.0000% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 22.6415% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.5882% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 33.3333% (minimum 75%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.1579% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 23.0769% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 60.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.1579% (minimum 75%, Baseline (adaptation disabled)); midbrain: 70.5882% (minimum 75%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 36.3636% (minimum 75%, Baseline (adaptation disabled)); stomach: 57.1429% (minimum 70%, Baseline (adaptation disabled))",0.0166667,-0.128571,-0.523585,0,80,unavailable,4.1,0.9,0.6,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000249884,RNF103-CHMP3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.6000% (minimum 99%, Missing); bone marrow: 89.7059% (minimum 99%, Missing); cerebral cortex: 97.6000% (minimum 99%, Missing); duodenum: 97.6000% (minimum 99%, Missing); lung: 98.3871% (minimum 99%, Missing); retina: 96.8254% (minimum 99%, Missing)",0.003125,0.006,-0.0929412,0,80,unavailable,1.4,0.3,0.6,"bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249961,TERB1,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.303125,0.276,0.147059,0,80,unavailable,1.4,0.3,0.6,"bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249961,TERB1,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.303125,0.276,0.147059,0,80,unavailable,1.4,0.3,0.6,"bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249961,TERB1,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.303125,0.276,0.147059,0,80,unavailable,1.4,0.3,0.6,"bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249961,TERB1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.303125,0.276,0.147059,0,80,unavailable,1.4,0.3,0.6,"bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000249961,TERB1,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Missing); adrenal gland: 82.6087% (minimum 99%, Missing); amygdala: 57.5758% (minimum 99%, Missing); basal ganglia: 55.8824% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 39.5833% (minimum 99%, Missing); cerebral cortex: 19.1919% (minimum 99%, Missing); choroid plexus: 86.3636% (minimum 99%, Missing); colon: 90.4762% (minimum 97%, Missing); duodenum: 86.3636% (minimum 99%, Missing); heart muscle: 95.0000% (minimum 99%, Missing); hippocampal formation: 57.5758% (minimum 99%, Missing); hypothalamus: 65.5172% (minimum 99%, Missing); kidney: 57.5758% (minimum 99%, Missing); lung: 73.0769% (minimum 99%, Missing); lymph node: 95.0000% (minimum 97%, Missing); midbrain: 59.3750% (minimum 99%, Missing); pancreas: 32.2034% (minimum 99%, Missing); parathyroid gland: 73.0769% (minimum 97%, Missing); pituitary gland: 57.5758% (minimum 99%, Missing); rectum: 95.0000% (minimum 97%, Missing); retina: 45.2381% (minimum 99%, Missing); salivary gland: 79.1667% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); small intestine: 73.0769% (minimum 99%, Missing); smooth muscle: 55.8824% (minimum 99%, Missing); spinal cord: 42.2222% (minimum 99%, Missing); stomach: 86.3636% (minimum 97%, Missing); thyroid gland: 48.7179% (minimum 95%, Missing); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 95.0000% (minimum 97%, Missing)",-0.462821,-0.239231,-0.798081,0,80,unavailable,8,0.7,2,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250120,PCDHA10,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 57.5758% (minimum 75%, Missing); basal ganglia: 55.8824% (minimum 75%, Missing); cerebellum: 39.5833% (minimum 75%, Missing); cerebral cortex: 19.1919% (minimum 75%, Missing); hippocampal formation: 57.5758% (minimum 75%, Missing); hypothalamus: 65.5172% (minimum 75%, Missing); kidney: 57.5758% (minimum 75%, Missing); lung: 73.0769% (minimum 75%, Missing); midbrain: 59.3750% (minimum 75%, Missing); pancreas: 32.2034% (minimum 75%, Missing); pituitary gland: 57.5758% (minimum 75%, Missing); retina: 45.2381% (minimum 75%, Missing); small intestine: 73.0769% (minimum 75%, Missing); smooth muscle: 55.8824% (minimum 75%, Missing); spinal cord: 42.2222% (minimum 75%, Missing); thyroid gland: 48.7179% (minimum 65%, Missing)",-0.162821,0.0307692,-0.558081,0,80,unavailable,8,0.7,2,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250120,PCDHA10,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 57.5758% (minimum 75%, Missing); basal ganglia: 55.8824% (minimum 75%, Missing); cerebellum: 39.5833% (minimum 75%, Missing); cerebral cortex: 19.1919% (minimum 75%, Missing); hippocampal formation: 57.5758% (minimum 75%, Missing); hypothalamus: 65.5172% (minimum 75%, Missing); kidney: 57.5758% (minimum 75%, Missing); lung: 73.0769% (minimum 75%, Missing); midbrain: 59.3750% (minimum 75%, Missing); pancreas: 32.2034% (minimum 75%, Missing); pituitary gland: 57.5758% (minimum 75%, Missing); retina: 45.2381% (minimum 75%, Missing); small intestine: 73.0769% (minimum 75%, Missing); smooth muscle: 55.8824% (minimum 75%, Missing); spinal cord: 42.2222% (minimum 75%, Missing); thyroid gland: 48.7179% (minimum 65%, Missing)",-0.162821,0.0307692,-0.558081,0,80,unavailable,8,0.7,2,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250120,PCDHA10,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 57.5758% (minimum 75%, Missing); basal ganglia: 55.8824% (minimum 75%, Missing); cerebellum: 39.5833% (minimum 75%, Missing); cerebral cortex: 19.1919% (minimum 75%, Missing); hippocampal formation: 57.5758% (minimum 75%, Missing); hypothalamus: 65.5172% (minimum 75%, Missing); kidney: 57.5758% (minimum 75%, Missing); lung: 73.0769% (minimum 75%, Missing); midbrain: 59.3750% (minimum 75%, Missing); pancreas: 32.2034% (minimum 75%, Missing); pituitary gland: 57.5758% (minimum 75%, Missing); retina: 45.2381% (minimum 75%, Missing); small intestine: 73.0769% (minimum 75%, Missing); smooth muscle: 55.8824% (minimum 75%, Missing); spinal cord: 42.2222% (minimum 75%, Missing); thyroid gland: 48.7179% (minimum 65%, Missing)",-0.162821,0.0307692,-0.558081,0,80,unavailable,8,0.7,2,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250120,PCDHA10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 57.5758% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 55.8824% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 39.5833% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 19.1919% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.5758% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.5172% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.5758% (minimum 75%, Baseline (adaptation disabled)); lung: 73.0769% (minimum 75%, Baseline (adaptation disabled)); midbrain: 59.3750% (minimum 75%, Baseline (adaptation disabled)); pancreas: 32.2034% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 57.5758% (minimum 75%, Baseline (adaptation disabled)); retina: 45.2381% (minimum 75%, Baseline (adaptation disabled)); small intestine: 73.0769% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 55.8824% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 42.2222% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 48.7179% (minimum 65%, Baseline (adaptation disabled))",-0.162821,0.0307692,-0.558081,0,80,unavailable,8,0.7,2,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250120,PCDHA10,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.0000% (minimum 95%, Missing); adrenal gland: 52.4590% (minimum 99%, Missing); amygdala: 71.1111% (minimum 99%, Missing); basal ganglia: 69.5652% (minimum 99%, Missing); bone marrow: 52.4590% (minimum 99%, Missing); cerebellum: 60.3774% (minimum 99%, Missing); cerebral cortex: 53.3333% (minimum 99%, Missing); choroid plexus: 72.7273% (minimum 99%, Missing); colon: 57.1429% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 65.3061% (minimum 97%, Missing); heart muscle: 62.7451% (minimum 99%, Missing); hippocampal formation: 71.1111% (minimum 99%, Missing); hypothalamus: 68.0851% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); liver: 69.5652% (minimum 99%, Missing); lung: 62.7451% (minimum 99%, Missing); lymph node: 46.3768% (minimum 97%, Missing); midbrain: 68.0851% (minimum 99%, Missing); pancreas: 56.1404% (minimum 99%, Missing); parathyroid gland: 55.1724% (minimum 97%, Missing); pituitary gland: 62.7451% (minimum 99%, Missing); rectum: 60.3774% (minimum 97%, Missing); retina: 55.1724% (minimum 99%, Missing); salivary gland: 60.3774% (minimum 97%, Missing); skeletal muscle: 78.0488% (minimum 99%, Missing); skin: 52.4590% (minimum 95%, Missing); small intestine: 64.0000% (minimum 99%, Missing); smooth muscle: 64.0000% (minimum 99%, Missing); spinal cord: 64.0000% (minimum 99%, Missing); spleen: 53.3333% (minimum 95%, Missing); stomach: 64.0000% (minimum 97%, Missing); thymus: 41.5584% (minimum 95%, Missing); thyroid gland: 41.0256% (minimum 95%, Missing); tongue: 65.3061% (minimum 97%, Missing); urinary bladder: 62.7451% (minimum 97%, Missing)",-0.539744,-0.506232,-0.46541,0,80,unavailable,2.9,3.7,4.6,"lymph node: 3.7 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250312,ZNF718,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.0000% (minimum 65%, Missing); adrenal gland: 52.4590% (minimum 75%, Missing); amygdala: 71.1111% (minimum 75%, Missing); basal ganglia: 69.5652% (minimum 75%, Missing); bone marrow: 52.4590% (minimum 75%, Missing); cerebellum: 60.3774% (minimum 75%, Missing); cerebral cortex: 53.3333% (minimum 75%, Missing); choroid plexus: 72.7273% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 65.3061% (minimum 70%, Missing); heart muscle: 62.7451% (minimum 75%, Missing); hippocampal formation: 71.1111% (minimum 75%, Missing); hypothalamus: 68.0851% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 69.5652% (minimum 75%, Missing); lung: 62.7451% (minimum 75%, Missing); lymph node: 46.3768% (minimum 70%, Missing); midbrain: 68.0851% (minimum 75%, Missing); pancreas: 56.1404% (minimum 75%, Missing); parathyroid gland: 55.1724% (minimum 70%, Missing); pituitary gland: 62.7451% (minimum 75%, Missing); rectum: 60.3774% (minimum 70%, Missing); retina: 55.1724% (minimum 75%, Missing); salivary gland: 60.3774% (minimum 70%, Missing); skin: 52.4590% (minimum 65%, Missing); small intestine: 64.0000% (minimum 75%, Missing); smooth muscle: 64.0000% (minimum 75%, Missing); spinal cord: 64.0000% (minimum 75%, Missing); spleen: 53.3333% (minimum 65%, Missing); stomach: 64.0000% (minimum 70%, Missing); thymus: 41.5584% (minimum 65%, Missing); thyroid gland: 41.0256% (minimum 65%, Missing); tongue: 65.3061% (minimum 70%, Missing); urinary bladder: 62.7451% (minimum 70%, Missing)",-0.239744,-0.236232,-0.22541,0,80,unavailable,2.9,3.7,4.6,"lymph node: 3.7 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250312,ZNF718,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.0000% (minimum 65%, Missing); adrenal gland: 52.4590% (minimum 75%, Missing); amygdala: 71.1111% (minimum 75%, Missing); basal ganglia: 69.5652% (minimum 75%, Missing); bone marrow: 52.4590% (minimum 75%, Missing); cerebellum: 60.3774% (minimum 75%, Missing); cerebral cortex: 53.3333% (minimum 75%, Missing); choroid plexus: 72.7273% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 65.3061% (minimum 70%, Missing); heart muscle: 62.7451% (minimum 75%, Missing); hippocampal formation: 71.1111% (minimum 75%, Missing); hypothalamus: 68.0851% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 69.5652% (minimum 75%, Missing); lung: 62.7451% (minimum 75%, Missing); lymph node: 46.3768% (minimum 70%, Missing); midbrain: 68.0851% (minimum 75%, Missing); pancreas: 56.1404% (minimum 75%, Missing); parathyroid gland: 55.1724% (minimum 70%, Missing); pituitary gland: 62.7451% (minimum 75%, Missing); rectum: 60.3774% (minimum 70%, Missing); retina: 55.1724% (minimum 75%, Missing); salivary gland: 60.3774% (minimum 70%, Missing); skin: 52.4590% (minimum 65%, Missing); small intestine: 64.0000% (minimum 75%, Missing); smooth muscle: 64.0000% (minimum 75%, Missing); spinal cord: 64.0000% (minimum 75%, Missing); spleen: 53.3333% (minimum 65%, Missing); stomach: 64.0000% (minimum 70%, Missing); thymus: 41.5584% (minimum 65%, Missing); thyroid gland: 41.0256% (minimum 65%, Missing); tongue: 65.3061% (minimum 70%, Missing); urinary bladder: 62.7451% (minimum 70%, Missing)",-0.239744,-0.236232,-0.22541,0,80,unavailable,2.9,3.7,4.6,"lymph node: 3.7 nTPM (protected, limit 3); adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250312,ZNF718,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.0000% (minimum 65%, Missing); adrenal gland: 52.4590% (minimum 75%, Missing); amygdala: 71.1111% (minimum 75%, Missing); basal ganglia: 69.5652% (minimum 75%, Missing); bone marrow: 52.4590% (minimum 75%, Missing); cerebellum: 60.3774% (minimum 75%, Missing); cerebral cortex: 53.3333% (minimum 75%, Missing); choroid plexus: 72.7273% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 65.3061% (minimum 70%, Missing); heart muscle: 62.7451% (minimum 75%, Missing); hippocampal formation: 71.1111% (minimum 75%, Missing); hypothalamus: 68.0851% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 69.5652% (minimum 75%, Missing); lung: 62.7451% (minimum 75%, Missing); lymph node: 46.3768% (minimum 70%, Missing); midbrain: 68.0851% (minimum 75%, Missing); pancreas: 56.1404% (minimum 75%, Missing); parathyroid gland: 55.1724% (minimum 70%, Missing); pituitary gland: 62.7451% (minimum 75%, Missing); rectum: 60.3774% (minimum 70%, Missing); retina: 55.1724% (minimum 75%, Missing); salivary gland: 60.3774% (minimum 70%, Missing); skin: 52.4590% (minimum 65%, Missing); small intestine: 64.0000% (minimum 75%, Missing); smooth muscle: 64.0000% (minimum 75%, Missing); spinal cord: 64.0000% (minimum 75%, Missing); spleen: 53.3333% (minimum 65%, Missing); stomach: 64.0000% (minimum 70%, Missing); thymus: 41.5584% (minimum 65%, Missing); thyroid gland: 41.0256% (minimum 65%, Missing); tongue: 65.3061% (minimum 70%, Missing); urinary bladder: 62.7451% (minimum 70%, Missing)",-0.239744,-0.236232,-0.22541,0,80,unavailable,2.9,3.7,4.6,"lymph node: 3.7 nTPM (protected, limit 3); adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250312,ZNF718,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.0000% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 52.4590% (minimum 75%, Baseline (adaptation disabled)); amygdala: 71.1111% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 69.5652% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 52.4590% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 60.3774% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.3333% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.7273% (minimum 75%, Baseline (adaptation disabled)); colon: 57.1429% (minimum 70%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.3061% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 62.7451% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.1111% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 68.0851% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 75%, Baseline (adaptation disabled)); liver: 69.5652% (minimum 75%, Baseline (adaptation disabled)); lung: 62.7451% (minimum 75%, Baseline (adaptation disabled)); lymph node: 46.3768% (minimum 70%, Baseline (adaptation disabled)); midbrain: 68.0851% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.1404% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.1724% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 62.7451% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.3774% (minimum 70%, Baseline (adaptation disabled)); retina: 55.1724% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.3774% (minimum 70%, Baseline (adaptation disabled)); skin: 52.4590% (minimum 65%, Baseline (adaptation disabled)); small intestine: 64.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 64.0000% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 64.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 53.3333% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 41.5584% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 41.0256% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.3061% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 62.7451% (minimum 70%, Baseline (adaptation disabled))",-0.239744,-0.236232,-0.22541,0,80,unavailable,2.9,3.7,4.6,"lymph node: 3.7 nTPM (protected, limit 3); adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250312,ZNF718,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.00755501,0,3,partial,1.3,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250423,KIAA1210,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.247555,0,3,partial,1.3,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250423,KIAA1210,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.247555,0,3,partial,1.3,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250423,KIAA1210,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.247555,0,3,partial,1.3,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250423,KIAA1210,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.219121,0,3,partial,1.3,0,0,"adrenal gland: 1.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250423,KIAA1210,current_fixed,True,False,False,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.6174% (minimum 95%, Enhanced); amygdala: 88.7460% (minimum 99%, Missing); basal ganglia: 86.7925% (minimum 99%, Missing); cerebral cortex: 89.9023% (minimum 95%, Enhanced); choroid plexus: 93.2432% (minimum 99%, Missing); colon: 94.5205% (minimum 97%, Missing); duodenum: 98.5714% (minimum 99%, Missing); heart muscle: 94.8454% (minimum 95%, Enhanced); hippocampal formation: 89.3204% (minimum 99%, Missing); hypothalamus: 91.3907% (minimum 99%, Missing); kidney: 93.2432% (minimum 95%, Enhanced); liver: 93.5593% (minimum 95%, Enhanced); midbrain: 88.4615% (minimum 99%, Missing); pancreas: 91.0891% (minimum 95%, Enhanced); pituitary gland: 91.0891% (minimum 99%, Missing); retina: 92.3077% (minimum 99%, Missing); skeletal muscle: 89.3204% (minimum 95%, Enhanced); small intestine: 95.5017% (minimum 99%, Missing); spinal cord: 87.8981% (minimum 99%, Missing); tongue: 95.5017% (minimum 97%, Missing)",0.00833333,-0.0247945,-0.122075,0,8,partial,4.2,2.3,2.8,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250565,ATP6V1E2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.245205,0.117925,0,8,partial,4.2,2.3,2.8,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250565,ATP6V1E2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.245205,0.117925,0,8,partial,4.2,2.3,2.8,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250565,ATP6V1E2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.245205,0.117925,0,8,partial,4.2,2.3,2.8,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250565,ATP6V1E2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.257895,0.223077,0.117925,0,8,partial,4.2,2.3,2.8,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250565,ATP6V1E2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"heart muscle: 96.1165% (minimum 99%, Missing); kidney: 98.0198% (minimum 99%, Missing)",0.04,0.000588235,-0.028835,0,80,unavailable,0.4,0.3,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250709,CCDC169-SOHLH2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.34,0.270588,0.211165,0,80,unavailable,0.4,0.3,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250709,CCDC169-SOHLH2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.34,0.270588,0.211165,0,80,unavailable,0.4,0.3,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250709,CCDC169-SOHLH2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.34,0.270588,0.211165,0,80,unavailable,0.4,0.3,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250709,CCDC169-SOHLH2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.34,0.270588,0.211165,0,80,unavailable,0.4,0.3,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250709,CCDC169-SOHLH2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250719,P3R3URF,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250719,P3R3URF,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250719,P3R3URF,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250719,P3R3URF,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250719,P3R3URF,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.05,0.03,0.00382716,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250741,NT5C1B-RDH14,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.243827,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250741,NT5C1B-RDH14,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.243827,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250741,NT5C1B-RDH14,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.243827,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250741,NT5C1B-RDH14,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.243827,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000250741,NT5C1B-RDH14,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0489837,0.03,0.00796954,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250803,ZNF475,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.348984,0.3,0.24797,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250803,ZNF475,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.348984,0.3,0.24797,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250803,ZNF475,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.348984,0.3,0.24797,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250803,ZNF475,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.348984,0.3,0.24797,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000250803,ZNF475,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 84.2105% (minimum 99%, Missing)",0.05,0.03,-0.147895,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000251258,RFPL4B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0921053,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000251258,RFPL4B,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0921053,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000251258,RFPL4B,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0921053,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000251258,RFPL4B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.0921053,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000251258,RFPL4B,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.1905% (minimum 95%, Missing); adrenal gland: 64.0000% (minimum 99%, Missing); amygdala: 74.4186% (minimum 99%, Missing); basal ganglia: 64.0000% (minimum 99%, Missing); cerebellum: 84.2105% (minimum 99%, Missing); cerebral cortex: 71.1111% (minimum 99%, Missing); choroid plexus: 68.0851% (minimum 99%, Missing); colon: 96.9697% (minimum 97%, Missing); esophagus: 65.3061% (minimum 97%, Missing); hippocampal formation: 74.4186% (minimum 99%, Missing); hypothalamus: 54.2373% (minimum 99%, Missing); kidney: 60.3774% (minimum 99%, Missing); lung: 91.4286% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); midbrain: 64.0000% (minimum 99%, Missing); parathyroid gland: 96.9697% (minimum 97%, Missing); pituitary gland: 62.7451% (minimum 99%, Missing); retina: 88.8889% (minimum 99%, Missing); salivary gland: 82.0513% (minimum 97%, Missing); skeletal muscle: 91.4286% (minimum 99%, Missing); skin: 72.7273% (minimum 95%, Missing); small intestine: 72.7273% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); stomach: 94.1176% (minimum 97%, Missing); thyroid gland: 91.4286% (minimum 95%, Missing); tongue: 62.7451% (minimum 97%, Missing); urinary bladder: 88.8889% (minimum 97%, Missing)",-0.222727,-0.342549,-0.447627,0,80,unavailable,2.7,1.9,1.2,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000251493,FOXD1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 64.0000% (minimum 75%, Missing); amygdala: 74.4186% (minimum 75%, Missing); basal ganglia: 64.0000% (minimum 75%, Missing); cerebral cortex: 71.1111% (minimum 75%, Missing); choroid plexus: 68.0851% (minimum 75%, Missing); esophagus: 65.3061% (minimum 70%, Missing); hippocampal formation: 74.4186% (minimum 75%, Missing); hypothalamus: 54.2373% (minimum 75%, Missing); kidney: 60.3774% (minimum 75%, Missing); midbrain: 64.0000% (minimum 75%, Missing); pituitary gland: 62.7451% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); tongue: 62.7451% (minimum 70%, Missing)",0.0772727,-0.072549,-0.207627,0,80,unavailable,2.7,1.9,1.2,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000251493,FOXD1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 64.0000% (minimum 75%, Missing); amygdala: 74.4186% (minimum 75%, Missing); basal ganglia: 64.0000% (minimum 75%, Missing); cerebral cortex: 71.1111% (minimum 75%, Missing); choroid plexus: 68.0851% (minimum 75%, Missing); esophagus: 65.3061% (minimum 70%, Missing); hippocampal formation: 74.4186% (minimum 75%, Missing); hypothalamus: 54.2373% (minimum 75%, Missing); kidney: 60.3774% (minimum 75%, Missing); midbrain: 64.0000% (minimum 75%, Missing); pituitary gland: 62.7451% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); tongue: 62.7451% (minimum 70%, Missing)",0.0772727,-0.072549,-0.207627,0,80,unavailable,2.7,1.9,1.2,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000251493,FOXD1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 64.0000% (minimum 75%, Missing); amygdala: 74.4186% (minimum 75%, Missing); basal ganglia: 64.0000% (minimum 75%, Missing); cerebral cortex: 71.1111% (minimum 75%, Missing); choroid plexus: 68.0851% (minimum 75%, Missing); esophagus: 65.3061% (minimum 70%, Missing); hippocampal formation: 74.4186% (minimum 75%, Missing); hypothalamus: 54.2373% (minimum 75%, Missing); kidney: 60.3774% (minimum 75%, Missing); midbrain: 64.0000% (minimum 75%, Missing); pituitary gland: 62.7451% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); tongue: 62.7451% (minimum 70%, Missing)",0.0772727,-0.072549,-0.207627,0,80,unavailable,2.7,1.9,1.2,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000251493,FOXD1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 64.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 74.4186% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 71.1111% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 68.0851% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.3061% (minimum 70%, Baseline (adaptation disabled)); hippocampal formation: 74.4186% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 54.2373% (minimum 75%, Baseline (adaptation disabled)); kidney: 60.3774% (minimum 75%, Baseline (adaptation disabled)); midbrain: 64.0000% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 62.7451% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.7273% (minimum 75%, Baseline (adaptation disabled)); tongue: 62.7451% (minimum 70%, Baseline (adaptation disabled))",0.0772727,-0.072549,-0.207627,0,80,unavailable,2.7,1.9,1.2,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000251493,FOXD1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 97.5069% (minimum 99%, Missing); amygdala: 89.7959% (minimum 99%, Missing); basal ganglia: 88.6650% (minimum 99%, Missing); bone marrow: 80.9195% (minimum 99%, Missing); cerebellum: 97.2376% (minimum 99%, Missing); cerebral cortex: 90.2564% (minimum 99%, Missing); choroid plexus: 98.8764% (minimum 99%, Missing); duodenum: 95.6522% (minimum 99%, Missing); esophagus: 96.1749% (minimum 97%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 90.9561% (minimum 99%, Missing); kidney: 94.1176% (minimum 99%, Missing); liver: 96.7033% (minimum 99%, Missing); lung: 98.3240% (minimum 99%, Missing); lymph node: 96.9697% (minimum 97%, Missing); midbrain: 92.3885% (minimum 99%, Missing); pancreas: 96.7033% (minimum 99%, Missing); parathyroid gland: 96.1749% (minimum 97%, Missing); pituitary gland: 93.6170% (minimum 99%, Missing); retina: 93.6170% (minimum 99%, Missing); small intestine: 98.3240% (minimum 99%, Missing); spinal cord: 94.8787% (minimum 99%, Missing); stomach: 96.7033% (minimum 97%, Missing); thymus: 94.6237% (minimum 95%, Missing)",-0.00376344,-0.00825137,-0.180805,0,80,unavailable,8.3,1.4,2,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000251503,CENPS-CORT,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.296237,0.261749,0.0591954,0,80,unavailable,8.3,1.4,2,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000251503,CENPS-CORT,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.296237,0.261749,0.0591954,0,80,unavailable,8.3,1.4,2,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000251503,CENPS-CORT,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.296237,0.261749,0.0591954,0,80,unavailable,8.3,1.4,2,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000251503,CENPS-CORT,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.296237,0.261749,0.0591954,0,80,unavailable,8.3,1.4,2,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000251503,CENPS-CORT,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5782% (minimum 99%, Missing); amygdala: 98.8906% (minimum 99%, Missing); basal ganglia: 98.8906% (minimum 99%, Missing); cerebellum: 98.8906% (minimum 99%, Missing); heart muscle: 98.5782% (minimum 99%, Missing); hippocampal formation: 98.8906% (minimum 99%, Missing); kidney: 98.4227% (minimum 99%, Missing); liver: 98.8906% (minimum 99%, Missing); lung: 98.8906% (minimum 99%, Missing); midbrain: 98.7342% (minimum 99%, Missing); pancreas: 98.2677% (minimum 99%, Missing); pituitary gland: 98.8906% (minimum 99%, Missing); skeletal muscle: 98.4227% (minimum 99%, Missing); small intestine: 98.8906% (minimum 99%, Missing); spinal cord: 98.7342% (minimum 99%, Missing)",0.0295918,0.0126772,-0.00732283,0,80,unavailable,1.1,1.1,1.3,"pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000253506,NACA2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329592,0.282677,0.232677,0,80,unavailable,1.1,1.1,1.3,"pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000253506,NACA2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329592,0.282677,0.232677,0,80,unavailable,1.1,1.1,1.3,"pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000253506,NACA2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329592,0.282677,0.232677,0,80,unavailable,1.1,1.1,1.3,"pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000253506,NACA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329592,0.282677,0.232677,0,80,unavailable,1.1,1.1,1.3,"pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000253506,NACA2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 75.6757% (minimum 99%, Missing); amygdala: 48.2759% (minimum 99%, Missing); basal ganglia: 48.2759% (minimum 99%, Missing); bone marrow: 96.5517% (minimum 99%, Missing); cerebellum: 46.6667% (minimum 99%, Missing); cerebral cortex: 43.7500% (minimum 99%, Missing); choroid plexus: 93.3333% (minimum 99%, Missing); colon: 73.6842% (minimum 97%, Missing); duodenum: 93.3333% (minimum 99%, Missing); esophagus: 77.7778% (minimum 97%, Missing); heart muscle: 62.2222% (minimum 99%, Missing); hippocampal formation: 57.1429% (minimum 99%, Missing); hypothalamus: 62.2222% (minimum 99%, Missing); kidney: 82.3529% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lung: 63.6364% (minimum 99%, Missing); lymph node: 90.3226% (minimum 97%, Missing); midbrain: 63.6364% (minimum 99%, Missing); pancreas: 77.7778% (minimum 99%, Missing); parathyroid gland: 71.7949% (minimum 97%, Missing); pituitary gland: 75.6757% (minimum 99%, Missing); rectum: 80.0000% (minimum 97%, Missing); retina: 65.1163% (minimum 99%, Missing); salivary gland: 77.7778% (minimum 97%, Missing); skeletal muscle: 77.7778% (minimum 99%, Missing); skin: 77.7778% (minimum 95%, Missing); small intestine: 84.8485% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 65.1163% (minimum 99%, Missing); spleen: 82.3529% (minimum 95%, Missing); stomach: 84.8485% (minimum 97%, Missing); thymus: 90.3226% (minimum 95%, Missing); thyroid gland: 82.3529% (minimum 95%, Missing); tongue: 77.7778% (minimum 97%, Missing); urinary bladder: 75.6757% (minimum 97%, Missing)",-0.283333,-0.252051,-0.5525,0,80,unavailable,3.6,1.1,1.4,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000253910,PCDHGB2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 48.2759% (minimum 75%, Missing); basal ganglia: 48.2759% (minimum 75%, Missing); cerebellum: 46.6667% (minimum 75%, Missing); cerebral cortex: 43.7500% (minimum 75%, Missing); heart muscle: 62.2222% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 62.2222% (minimum 75%, Missing); lung: 63.6364% (minimum 75%, Missing); midbrain: 63.6364% (minimum 75%, Missing); retina: 65.1163% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 65.1163% (minimum 75%, Missing)",0.0166667,0.0179487,-0.3125,0,80,unavailable,3.6,1.1,1.4,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000253910,PCDHGB2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 48.2759% (minimum 75%, Missing); basal ganglia: 48.2759% (minimum 75%, Missing); cerebellum: 46.6667% (minimum 75%, Missing); cerebral cortex: 43.7500% (minimum 75%, Missing); heart muscle: 62.2222% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 62.2222% (minimum 75%, Missing); lung: 63.6364% (minimum 75%, Missing); midbrain: 63.6364% (minimum 75%, Missing); retina: 65.1163% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 65.1163% (minimum 75%, Missing)",0.0166667,0.0179487,-0.3125,0,80,unavailable,3.6,1.1,1.4,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000253910,PCDHGB2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 48.2759% (minimum 75%, Missing); basal ganglia: 48.2759% (minimum 75%, Missing); cerebellum: 46.6667% (minimum 75%, Missing); cerebral cortex: 43.7500% (minimum 75%, Missing); heart muscle: 62.2222% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 62.2222% (minimum 75%, Missing); lung: 63.6364% (minimum 75%, Missing); midbrain: 63.6364% (minimum 75%, Missing); retina: 65.1163% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 65.1163% (minimum 75%, Missing)",0.0166667,0.0179487,-0.3125,0,80,unavailable,3.6,1.1,1.4,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000253910,PCDHGB2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 48.2759% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 48.2759% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 46.6667% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 43.7500% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 62.2222% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 57.1429% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.2222% (minimum 75%, Baseline (adaptation disabled)); lung: 63.6364% (minimum 75%, Baseline (adaptation disabled)); midbrain: 63.6364% (minimum 75%, Baseline (adaptation disabled)); retina: 65.1163% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 65.1163% (minimum 75%, Baseline (adaptation disabled))",0.0166667,0.0179487,-0.3125,0,80,unavailable,3.6,1.1,1.4,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000253910,PCDHGB2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.7500% (minimum 95%, Missing); adrenal gland: 61.1111% (minimum 99%, Missing); amygdala: 36.6667% (minimum 99%, Missing); basal ganglia: 36.6667% (minimum 99%, Missing); cerebellum: 52.3810% (minimum 99%, Missing); cerebral cortex: 8.1481% (minimum 99%, Missing); choroid plexus: 84.6154% (minimum 99%, Missing); colon: 78.5714% (minimum 97%, Missing); esophagus: 84.6154% (minimum 97%, Missing); heart muscle: 68.7500% (minimum 99%, Missing); hippocampal formation: 44.0000% (minimum 99%, Missing); hypothalamus: 50.0000% (minimum 99%, Missing); kidney: 73.3333% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 64.7059% (minimum 99%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 61.1111% (minimum 99%, Missing); parathyroid gland: 34.3750% (minimum 97%, Missing); pituitary gland: 52.3810% (minimum 99%, Missing); rectum: 91.6667% (minimum 97%, Missing); retina: 42.3077% (minimum 99%, Missing); salivary gland: 78.5714% (minimum 97%, Missing); skeletal muscle: 91.6667% (minimum 99%, Missing); skin: 84.6154% (minimum 95%, Missing); small intestine: 91.6667% (minimum 99%, Missing); smooth muscle: 57.8947% (minimum 99%, Missing); spinal cord: 47.8261% (minimum 99%, Missing); spleen: 91.6667% (minimum 95%, Missing); stomach: 91.6667% (minimum 97%, Missing); thyroid gland: 64.7059% (minimum 95%, Missing); tongue: 78.5714% (minimum 97%, Missing); urinary bladder: 78.5714% (minimum 97%, Missing)",-0.302941,-0.62625,-0.908519,0,80,unavailable,12.4,2.1,0.6,"cerebral cortex: 12.4 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254221,PCDHGB1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 36.6667% (minimum 75%, Missing); basal ganglia: 36.6667% (minimum 75%, Missing); cerebellum: 52.3810% (minimum 75%, Missing); cerebral cortex: 8.1481% (minimum 75%, Missing); heart muscle: 68.7500% (minimum 75%, Missing); hippocampal formation: 44.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); lung: 64.7059% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 61.1111% (minimum 75%, Missing); parathyroid gland: 34.3750% (minimum 70%, Missing); pituitary gland: 52.3810% (minimum 75%, Missing); retina: 42.3077% (minimum 75%, Missing); smooth muscle: 57.8947% (minimum 75%, Missing); spinal cord: 47.8261% (minimum 75%, Missing); thyroid gland: 64.7059% (minimum 65%, Missing)",-0.00294118,-0.35625,-0.668519,0,80,unavailable,12.4,2.1,0.6,"cerebral cortex: 12.4 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254221,PCDHGB1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 36.6667% (minimum 75%, Missing); basal ganglia: 36.6667% (minimum 75%, Missing); cerebellum: 52.3810% (minimum 75%, Missing); cerebral cortex: 8.1481% (minimum 75%, Missing); heart muscle: 68.7500% (minimum 75%, Missing); hippocampal formation: 44.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); lung: 64.7059% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 61.1111% (minimum 75%, Missing); parathyroid gland: 34.3750% (minimum 70%, Missing); pituitary gland: 52.3810% (minimum 75%, Missing); retina: 42.3077% (minimum 75%, Missing); smooth muscle: 57.8947% (minimum 75%, Missing); spinal cord: 47.8261% (minimum 75%, Missing); thyroid gland: 64.7059% (minimum 65%, Missing)",-0.00294118,-0.35625,-0.668519,0,80,unavailable,12.4,2.1,0.6,"cerebral cortex: 12.4 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254221,PCDHGB1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 36.6667% (minimum 75%, Missing); basal ganglia: 36.6667% (minimum 75%, Missing); cerebellum: 52.3810% (minimum 75%, Missing); cerebral cortex: 8.1481% (minimum 75%, Missing); heart muscle: 68.7500% (minimum 75%, Missing); hippocampal formation: 44.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); lung: 64.7059% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 61.1111% (minimum 75%, Missing); parathyroid gland: 34.3750% (minimum 70%, Missing); pituitary gland: 52.3810% (minimum 75%, Missing); retina: 42.3077% (minimum 75%, Missing); smooth muscle: 57.8947% (minimum 75%, Missing); spinal cord: 47.8261% (minimum 75%, Missing); thyroid gland: 64.7059% (minimum 65%, Missing)",-0.00294118,-0.35625,-0.668519,0,80,unavailable,12.4,2.1,0.6,"cerebral cortex: 12.4 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254221,PCDHGB1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 61.1111% (minimum 75%, Baseline (adaptation disabled)); amygdala: 36.6667% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 36.6667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 52.3810% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 8.1481% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 68.7500% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 44.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 50.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 73.3333% (minimum 75%, Baseline (adaptation disabled)); lung: 64.7059% (minimum 75%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 61.1111% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 34.3750% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 52.3810% (minimum 75%, Baseline (adaptation disabled)); retina: 42.3077% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 57.8947% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 47.8261% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 64.7059% (minimum 65%, Baseline (adaptation disabled))",-0.00294118,-0.35625,-0.668519,0,80,unavailable,12.4,2.1,0.6,"cerebral cortex: 12.4 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254221,PCDHGB1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.6106% (minimum 95%, Missing); adrenal gland: 96.1165% (minimum 99%, Missing); colon: 96.1165% (minimum 97%, Missing); duodenum: 97.0588% (minimum 99%, Missing); esophagus: 94.2857% (minimum 97%, Missing); heart muscle: 85.3448% (minimum 99%, Missing); kidney: 90.8257% (minimum 99%, Missing); lung: 95.1923% (minimum 99%, Missing); midbrain: 98.0198% (minimum 99%, Missing); pancreas: 97.0588% (minimum 99%, Missing); parathyroid gland: 65.5629% (minimum 97%, Missing); pituitary gland: 97.0588% (minimum 99%, Missing); salivary gland: 82.5000% (minimum 97%, Missing); skeletal muscle: 98.0198% (minimum 99%, Missing); small intestine: 97.0588% (minimum 99%, Missing); smooth muscle: 81.1475% (minimum 99%, Missing); thymus: 91.6667% (minimum 95%, Missing); thyroid gland: 83.1933% (minimum 95%, Missing); tongue: 92.5234% (minimum 97%, Missing); urinary bladder: 94.2857% (minimum 97%, Missing)",-0.118067,-0.314371,-0.178525,0,80,unavailable,2.3,5.2,2,"parathyroid gland: 5.2 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254535,PABPC4L,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 65.5629% (minimum 70%, Missing)",0.181933,-0.0443709,0.0614754,0,80,unavailable,2.3,5.2,2,"parathyroid gland: 5.2 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254535,PABPC4L,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 65.5629% (minimum 70%, Missing)",0.181933,-0.0443709,0.0614754,0,80,unavailable,2.3,5.2,2,"parathyroid gland: 5.2 nTPM (protected, limit 3); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254535,PABPC4L,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 65.5629% (minimum 70%, Missing)",0.181933,-0.0443709,0.0614754,0,80,unavailable,2.3,5.2,2,"parathyroid gland: 5.2 nTPM (protected, limit 3); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254535,PABPC4L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 65.5629% (minimum 70%, Baseline (adaptation disabled))",0.181933,-0.0443709,0.0614754,0,80,unavailable,2.3,5.2,2,"parathyroid gland: 5.2 nTPM (protected, limit 3); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254535,PABPC4L,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2759% (minimum 99%, Missing); amygdala: 86.3636% (minimum 99%, Missing); basal ganglia: 90.4762% (minimum 99%, Missing); bone marrow: 93.4426% (minimum 99%, Missing); cerebellum: 87.6923% (minimum 99%, Missing); cerebral cortex: 73.0769% (minimum 99%, Missing); choroid plexus: 96.6102% (minimum 99%, Missing); colon: 93.4426% (minimum 97%, Missing); duodenum: 95.0000% (minimum 99%, Missing); esophagus: 89.0625% (minimum 97%, Missing); heart muscle: 98.2759% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 90.4762% (minimum 99%, Missing); kidney: 87.6923% (minimum 99%, Missing); liver: 85.0746% (minimum 99%, Missing); lung: 93.4426% (minimum 99%, Missing); lymph node: 96.6102% (minimum 97%, Missing); midbrain: 91.9355% (minimum 99%, Missing); pancreas: 93.4426% (minimum 99%, Missing); parathyroid gland: 95.0000% (minimum 97%, Missing); pituitary gland: 96.6102% (minimum 99%, Missing); rectum: 93.4426% (minimum 97%, Missing); retina: 85.0746% (minimum 99%, Missing); salivary gland: 83.8235% (minimum 97%, Missing); skin: 93.4426% (minimum 95%, Missing); small intestine: 95.0000% (minimum 99%, Missing); smooth muscle: 89.0625% (minimum 99%, Missing); spinal cord: 91.9355% (minimum 99%, Missing); stomach: 95.0000% (minimum 97%, Missing); thymus: 86.3636% (minimum 95%, Missing); urinary bladder: 89.0625% (minimum 97%, Missing)",-0.0863636,-0.131765,-0.259231,0,80,unavailable,2.1,1.1,0.9,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254726,MEX3A,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 73.0769% (minimum 75%, Missing)",0.213636,0.138235,-0.0192308,0,80,unavailable,2.1,1.1,0.9,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254726,MEX3A,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 73.0769% (minimum 75%, Missing)",0.213636,0.138235,-0.0192308,0,80,unavailable,2.1,1.1,0.9,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254726,MEX3A,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 73.0769% (minimum 75%, Missing)",0.213636,0.138235,-0.0192308,0,80,unavailable,2.1,1.1,0.9,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254726,MEX3A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 73.0769% (minimum 75%, Baseline (adaptation disabled))",0.213636,0.138235,-0.0192308,0,80,unavailable,2.1,1.1,0.9,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000254726,MEX3A,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.1923% (minimum 99%, Uncertain); amygdala: 97.0588% (minimum 99%, Missing); basal ganglia: 96.1165% (minimum 99%, Missing); bone marrow: 91.9505% (minimum 99%, Uncertain); cerebellum: 95.4984% (minimum 99%, Missing); cerebral cortex: 96.4286% (minimum 99%, Uncertain); choroid plexus: 97.6974% (minimum 99%, Missing); colon: 95.1923% (minimum 97%, Missing); duodenum: 98.6711% (minimum 99%, Uncertain); heart muscle: 96.9005% (minimum 99%, Missing); hippocampal formation: 96.2723% (minimum 99%, Missing); hypothalamus: 95.9612% (minimum 99%, Missing); kidney: 97.2177% (minimum 99%, Missing); liver: 97.6974% (minimum 99%, Uncertain); lung: 95.3451% (minimum 99%, Uncertain); lymph node: 90.8257% (minimum 97%, Uncertain); midbrain: 97.3770% (minimum 99%, Missing); pancreas: 96.1165% (minimum 99%, Uncertain); pituitary gland: 94.2857% (minimum 99%, Missing); retina: 90.2736% (minimum 99%, Missing); small intestine: 95.8065% (minimum 99%, Uncertain); smooth muscle: 96.4286% (minimum 99%, Uncertain); spinal cord: 97.2177% (minimum 99%, Missing); stomach: 96.5854% (minimum 97%, Uncertain); thymus: 94.2857% (minimum 95%, Missing); urinary bladder: 96.2723% (minimum 97%, Uncertain)",-0.00714286,-0.0617431,-0.0872644,0,2,partial,6.4,6,3.6,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255150,EID3,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.292857,0.208257,0.152736,0,2,partial,6.4,6,3.6,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255150,EID3,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.292857,0.208257,0.152736,0,2,partial,6.4,6,3.6,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255150,EID3,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.292857,0.208257,0.152736,0,2,partial,6.4,6,3.6,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255150,EID3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.292857,0.208257,0.152736,0,2,partial,6.4,6,3.6,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255150,EID3,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 97.5610% (minimum 99%, Missing)",0.05,0.03,-0.0143902,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255181,CCDC166,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22561,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255181,CCDC166,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22561,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255181,CCDC166,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22561,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255181,CCDC166,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.22561,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255181,CCDC166,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"urinary bladder: 50.0000% (minimum 97%, Missing)",0.05,-0.47,0.01,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255223,OR5M11,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"urinary bladder: 50.0000% (minimum 70%, Missing)",0.35,-0.2,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255223,OR5M11,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"urinary bladder: 50.0000% (minimum 70%, Missing)",0.35,-0.2,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255223,OR5M11,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"urinary bladder: 50.0000% (minimum 70%, Missing)",0.35,-0.2,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255223,OR5M11,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"urinary bladder: 50.0000% (minimum 70%, Baseline (adaptation disabled))",0.35,-0.2,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255223,OR5M11,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.00945025,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255251,PRR23D1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.24945,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255251,PRR23D1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.24945,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255251,PRR23D1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.24945,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255251,PRR23D1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.24945,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255251,PRR23D1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255298,OR8G5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255298,OR8G5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255298,OR8G5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255298,OR8G5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255298,OR8G5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.9091% (minimum 99%, Missing); esophagus: 90.9091% (minimum 97%, Missing); kidney: 90.9091% (minimum 99%, Missing); retina: 90.9091% (minimum 99%, Missing); smooth muscle: 55.5556% (minimum 99%, Missing); spleen: 10.6383% (minimum 95%, Missing); stomach: 90.9091% (minimum 97%, Missing)",-0.843617,-0.0609091,-0.434444,0,80,unavailable,0.8,0.1,8.4,"spleen: 8.4 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255346,NOX5,admission_only,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"smooth muscle: 55.5556% (minimum 75%, Missing); spleen: 10.6383% (minimum 65%, Missing)",-0.543617,0.209091,-0.194444,0,80,unavailable,0.8,0.1,8.4,"spleen: 8.4 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255346,NOX5,selectivity_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"smooth muscle: 55.5556% (minimum 75%, Missing); spleen: 10.6383% (minimum 65%, Missing)",-0.543617,0.209091,-0.194444,0,80,unavailable,0.8,0.1,8.4,"spleen: 8.4 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255346,NOX5,grid_revised,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"smooth muscle: 55.5556% (minimum 75%, Missing); spleen: 10.6383% (minimum 65%, Missing)",-0.543617,0.209091,-0.194444,0,80,unavailable,0.8,0.1,8.4,"spleen: 8.4 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255346,NOX5,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"smooth muscle: 55.5556% (minimum 75%, Baseline (adaptation disabled)); spleen: 10.6383% (minimum 65%, Baseline (adaptation disabled))",-0.543617,0.209091,-0.194444,0,80,unavailable,0.8,0.1,8.4,"spleen: 8.4 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255346,NOX5,current_fixed,True,False,False,False,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255359,CCDC179,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255359,CCDC179,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255359,CCDC179,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255359,CCDC179,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255359,CCDC179,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 92.8571% (minimum 99%, Missing); hippocampal formation: 92.8571% (minimum 99%, Missing); hypothalamus: 92.8571% (minimum 99%, Missing); pancreas: 92.8571% (minimum 99%, Missing); spinal cord: 92.8571% (minimum 99%, Missing)",0.05,0.03,-0.0614286,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255378,PRR23D2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.178571,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255378,PRR23D2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.178571,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255378,PRR23D2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.178571,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255378,PRR23D2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.178571,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000255378,PRR23D2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.4706% (minimum 95%, Missing); adrenal gland: 65.0000% (minimum 99%, Missing); amygdala: 56.5217% (minimum 99%, Missing); basal ganglia: 54.1667% (minimum 99%, Missing); cerebellum: 39.3939% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); colon: 72.2222% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); esophagus: 92.8571% (minimum 97%, Missing); heart muscle: 81.2500% (minimum 99%, Missing); hippocampal formation: 54.1667% (minimum 99%, Missing); hypothalamus: 54.1667% (minimum 99%, Missing); kidney: 68.4211% (minimum 99%, Missing); lung: 61.9048% (minimum 99%, Missing); lymph node: 92.8571% (minimum 97%, Missing); midbrain: 61.9048% (minimum 99%, Missing); pancreas: 54.1667% (minimum 99%, Missing); parathyroid gland: 92.8571% (minimum 97%, Missing); pituitary gland: 48.1481% (minimum 99%, Missing); rectum: 92.8571% (minimum 97%, Missing); retina: 59.0909% (minimum 99%, Missing); salivary gland: 92.8571% (minimum 97%, Missing); skeletal muscle: 92.8571% (minimum 99%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 81.2500% (minimum 99%, Missing); smooth muscle: 81.2500% (minimum 99%, Missing); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 86.6667% (minimum 95%, Missing); stomach: 86.6667% (minimum 97%, Missing); thyroid gland: 72.2222% (minimum 95%, Missing); urinary bladder: 86.6667% (minimum 97%, Missing)",-0.227778,-0.247778,-0.596061,0,80,unavailable,2,0.5,0.5,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255408,PCDHA3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.0000% (minimum 75%, Missing); amygdala: 56.5217% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebellum: 39.3939% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 54.1667% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); lung: 61.9048% (minimum 75%, Missing); midbrain: 61.9048% (minimum 75%, Missing); pancreas: 54.1667% (minimum 75%, Missing); pituitary gland: 48.1481% (minimum 75%, Missing); retina: 59.0909% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing)",0.0722222,0.0222222,-0.356061,0,80,unavailable,2,0.5,0.5,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255408,PCDHA3,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.0000% (minimum 75%, Missing); amygdala: 56.5217% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebellum: 39.3939% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 54.1667% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); lung: 61.9048% (minimum 75%, Missing); midbrain: 61.9048% (minimum 75%, Missing); pancreas: 54.1667% (minimum 75%, Missing); pituitary gland: 48.1481% (minimum 75%, Missing); retina: 59.0909% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing)",0.0722222,0.0222222,-0.356061,0,80,unavailable,2,0.5,0.5,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255408,PCDHA3,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.0000% (minimum 75%, Missing); amygdala: 56.5217% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebellum: 39.3939% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 54.1667% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); lung: 61.9048% (minimum 75%, Missing); midbrain: 61.9048% (minimum 75%, Missing); pancreas: 54.1667% (minimum 75%, Missing); pituitary gland: 48.1481% (minimum 75%, Missing); retina: 59.0909% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing)",0.0722222,0.0222222,-0.356061,0,80,unavailable,2,0.5,0.5,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255408,PCDHA3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.0000% (minimum 75%, Baseline (adaptation disabled)); amygdala: 56.5217% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 54.1667% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 39.3939% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 54.1667% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 54.1667% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.4211% (minimum 75%, Baseline (adaptation disabled)); lung: 61.9048% (minimum 75%, Baseline (adaptation disabled)); midbrain: 61.9048% (minimum 75%, Baseline (adaptation disabled)); pancreas: 54.1667% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 48.1481% (minimum 75%, Baseline (adaptation disabled)); retina: 59.0909% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 75%, Baseline (adaptation disabled))",0.0722222,0.0222222,-0.356061,0,80,unavailable,2,0.5,0.5,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255408,PCDHA3,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.2447% (minimum 95%, Missing); adrenal gland: 63.3962% (minimum 99%, Missing); amygdala: 62.4535% (minimum 99%, Missing); basal ganglia: 64.9903% (minimum 99%, Missing); bone marrow: 66.7992% (minimum 99%, Missing); cerebellum: 75.1678% (minimum 99%, Missing); cerebral cortex: 64.2447% (minimum 99%, Missing); choroid plexus: 77.9582% (minimum 99%, Missing); colon: 69.1358% (minimum 97%, Missing); duodenum: 73.8462% (minimum 99%, Missing); esophagus: 69.4215% (minimum 97%, Missing); heart muscle: 54.4571% (minimum 99%, Missing); hippocampal formation: 63.2768% (minimum 99%, Missing); hypothalamus: 62.9213% (minimum 99%, Missing); kidney: 63.3962% (minimum 99%, Missing); liver: 69.2784% (minimum 99%, Missing); lung: 70.8861% (minimum 99%, Missing); lymph node: 64.2447% (minimum 97%, Missing); midbrain: 58.0311% (minimum 99%, Missing); pancreas: 68.2927% (minimum 99%, Missing); parathyroid gland: 57.6329% (minimum 97%, Missing); pituitary gland: 79.2453% (minimum 99%, Missing); rectum: 69.7095% (minimum 97%, Missing); retina: 73.2026% (minimum 99%, Missing); salivary gland: 68.2927% (minimum 97%, Missing); skeletal muscle: 49.1947% (minimum 99%, Missing); skin: 69.2784% (minimum 95%, Missing); small intestine: 72.4138% (minimum 99%, Missing); smooth muscle: 56.2814% (minimum 99%, Missing); spinal cord: 58.0311% (minimum 99%, Missing); spleen: 61.8785% (minimum 95%, Missing); stomach: 69.7095% (minimum 97%, Missing); thymus: 61.7647% (minimum 95%, Missing); thyroid gland: 58.9474% (minimum 95%, Missing); tongue: 47.3239% (minimum 97%, Missing); urinary bladder: 69.7095% (minimum 97%, Missing)",-0.360526,-0.496761,-0.498053,0,80,unavailable,34.7,37.4,23.4,"tongue: 37.4 nTPM (protected, limit 2); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 2); midbrain: 24.3 nTPM (vital, limit 1); spinal cord: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); thymus: 20.8 nTPM (manageable, limit 5); spleen: 20.7 nTPM (manageable, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 2); adipose tissue: 18.7 nTPM (manageable, limit 5); cerebral cortex: 18.7 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 2); colon: 15 nTPM (protected, limit 2); skin: 14.9 nTPM (manageable, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 2); stomach: 14.6 nTPM (protected, limit 2); urinary bladder: 14.6 nTPM (protected, limit 2); rectum: 14.6 nTPM (protected, limit 2); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255529,POLR2M,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.2447% (minimum 65%, Missing); adrenal gland: 63.3962% (minimum 75%, Missing); amygdala: 62.4535% (minimum 75%, Missing); basal ganglia: 64.9903% (minimum 75%, Missing); bone marrow: 66.7992% (minimum 75%, Missing); cerebral cortex: 64.2447% (minimum 75%, Missing); colon: 69.1358% (minimum 70%, Missing); duodenum: 73.8462% (minimum 75%, Missing); esophagus: 69.4215% (minimum 70%, Missing); heart muscle: 54.4571% (minimum 75%, Missing); hippocampal formation: 63.2768% (minimum 75%, Missing); hypothalamus: 62.9213% (minimum 75%, Missing); kidney: 63.3962% (minimum 75%, Missing); liver: 69.2784% (minimum 75%, Missing); lung: 70.8861% (minimum 75%, Missing); lymph node: 64.2447% (minimum 70%, Missing); midbrain: 58.0311% (minimum 75%, Missing); pancreas: 68.2927% (minimum 75%, Missing); parathyroid gland: 57.6329% (minimum 70%, Missing); rectum: 69.7095% (minimum 70%, Missing); retina: 73.2026% (minimum 75%, Missing); salivary gland: 68.2927% (minimum 70%, Missing); skeletal muscle: 49.1947% (minimum 75%, Missing); small intestine: 72.4138% (minimum 75%, Missing); smooth muscle: 56.2814% (minimum 75%, Missing); spinal cord: 58.0311% (minimum 75%, Missing); spleen: 61.8785% (minimum 65%, Missing); stomach: 69.7095% (minimum 70%, Missing); thymus: 61.7647% (minimum 65%, Missing); thyroid gland: 58.9474% (minimum 65%, Missing); tongue: 47.3239% (minimum 70%, Missing); urinary bladder: 69.7095% (minimum 70%, Missing)",-0.0605263,-0.226761,-0.258053,0,80,unavailable,34.7,37.4,23.4,"tongue: 37.4 nTPM (protected, limit 2); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 2); midbrain: 24.3 nTPM (vital, limit 1); spinal cord: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); thymus: 20.8 nTPM (manageable, limit 5); spleen: 20.7 nTPM (manageable, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 2); adipose tissue: 18.7 nTPM (manageable, limit 5); cerebral cortex: 18.7 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 2); colon: 15 nTPM (protected, limit 2); skin: 14.9 nTPM (manageable, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 2); stomach: 14.6 nTPM (protected, limit 2); urinary bladder: 14.6 nTPM (protected, limit 2); rectum: 14.6 nTPM (protected, limit 2); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255529,POLR2M,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.2447% (minimum 65%, Missing); adrenal gland: 63.3962% (minimum 75%, Missing); amygdala: 62.4535% (minimum 75%, Missing); basal ganglia: 64.9903% (minimum 75%, Missing); bone marrow: 66.7992% (minimum 75%, Missing); cerebral cortex: 64.2447% (minimum 75%, Missing); colon: 69.1358% (minimum 70%, Missing); duodenum: 73.8462% (minimum 75%, Missing); esophagus: 69.4215% (minimum 70%, Missing); heart muscle: 54.4571% (minimum 75%, Missing); hippocampal formation: 63.2768% (minimum 75%, Missing); hypothalamus: 62.9213% (minimum 75%, Missing); kidney: 63.3962% (minimum 75%, Missing); liver: 69.2784% (minimum 75%, Missing); lung: 70.8861% (minimum 75%, Missing); lymph node: 64.2447% (minimum 70%, Missing); midbrain: 58.0311% (minimum 75%, Missing); pancreas: 68.2927% (minimum 75%, Missing); parathyroid gland: 57.6329% (minimum 70%, Missing); rectum: 69.7095% (minimum 70%, Missing); retina: 73.2026% (minimum 75%, Missing); salivary gland: 68.2927% (minimum 70%, Missing); skeletal muscle: 49.1947% (minimum 75%, Missing); small intestine: 72.4138% (minimum 75%, Missing); smooth muscle: 56.2814% (minimum 75%, Missing); spinal cord: 58.0311% (minimum 75%, Missing); spleen: 61.8785% (minimum 65%, Missing); stomach: 69.7095% (minimum 70%, Missing); thymus: 61.7647% (minimum 65%, Missing); thyroid gland: 58.9474% (minimum 65%, Missing); tongue: 47.3239% (minimum 70%, Missing); urinary bladder: 69.7095% (minimum 70%, Missing)",-0.0605263,-0.226761,-0.258053,0,80,unavailable,34.7,37.4,23.4,"tongue: 37.4 nTPM (protected, limit 3); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 3); midbrain: 24.3 nTPM (vital, limit 1); spinal cord: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); thymus: 20.8 nTPM (manageable, limit 5); spleen: 20.7 nTPM (manageable, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 3); adipose tissue: 18.7 nTPM (manageable, limit 5); cerebral cortex: 18.7 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 3); colon: 15 nTPM (protected, limit 3); skin: 14.9 nTPM (manageable, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 3); stomach: 14.6 nTPM (protected, limit 3); urinary bladder: 14.6 nTPM (protected, limit 3); rectum: 14.6 nTPM (protected, limit 3); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255529,POLR2M,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.2447% (minimum 65%, Missing); adrenal gland: 63.3962% (minimum 75%, Missing); amygdala: 62.4535% (minimum 75%, Missing); basal ganglia: 64.9903% (minimum 75%, Missing); bone marrow: 66.7992% (minimum 75%, Missing); cerebral cortex: 64.2447% (minimum 75%, Missing); colon: 69.1358% (minimum 70%, Missing); duodenum: 73.8462% (minimum 75%, Missing); esophagus: 69.4215% (minimum 70%, Missing); heart muscle: 54.4571% (minimum 75%, Missing); hippocampal formation: 63.2768% (minimum 75%, Missing); hypothalamus: 62.9213% (minimum 75%, Missing); kidney: 63.3962% (minimum 75%, Missing); liver: 69.2784% (minimum 75%, Missing); lung: 70.8861% (minimum 75%, Missing); lymph node: 64.2447% (minimum 70%, Missing); midbrain: 58.0311% (minimum 75%, Missing); pancreas: 68.2927% (minimum 75%, Missing); parathyroid gland: 57.6329% (minimum 70%, Missing); rectum: 69.7095% (minimum 70%, Missing); retina: 73.2026% (minimum 75%, Missing); salivary gland: 68.2927% (minimum 70%, Missing); skeletal muscle: 49.1947% (minimum 75%, Missing); small intestine: 72.4138% (minimum 75%, Missing); smooth muscle: 56.2814% (minimum 75%, Missing); spinal cord: 58.0311% (minimum 75%, Missing); spleen: 61.8785% (minimum 65%, Missing); stomach: 69.7095% (minimum 70%, Missing); thymus: 61.7647% (minimum 65%, Missing); thyroid gland: 58.9474% (minimum 65%, Missing); tongue: 47.3239% (minimum 70%, Missing); urinary bladder: 69.7095% (minimum 70%, Missing)",-0.0605263,-0.226761,-0.258053,0,80,unavailable,34.7,37.4,23.4,"tongue: 37.4 nTPM (protected, limit 3); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 3); midbrain: 24.3 nTPM (vital, limit 1); spinal cord: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); thymus: 20.8 nTPM (manageable, limit 5); spleen: 20.7 nTPM (manageable, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 3); adipose tissue: 18.7 nTPM (manageable, limit 5); cerebral cortex: 18.7 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 3); colon: 15 nTPM (protected, limit 3); skin: 14.9 nTPM (manageable, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 3); stomach: 14.6 nTPM (protected, limit 3); urinary bladder: 14.6 nTPM (protected, limit 3); rectum: 14.6 nTPM (protected, limit 3); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255529,POLR2M,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.2447% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.3962% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.4535% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 64.9903% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 66.7992% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 64.2447% (minimum 75%, Baseline (adaptation disabled)); colon: 69.1358% (minimum 70%, Baseline (adaptation disabled)); duodenum: 73.8462% (minimum 75%, Baseline (adaptation disabled)); esophagus: 69.4215% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 54.4571% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.2768% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 62.9213% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.3962% (minimum 75%, Baseline (adaptation disabled)); liver: 69.2784% (minimum 75%, Baseline (adaptation disabled)); lung: 70.8861% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.2447% (minimum 70%, Baseline (adaptation disabled)); midbrain: 58.0311% (minimum 75%, Baseline (adaptation disabled)); pancreas: 68.2927% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.6329% (minimum 70%, Baseline (adaptation disabled)); rectum: 69.7095% (minimum 70%, Baseline (adaptation disabled)); retina: 73.2026% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.2927% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 49.1947% (minimum 75%, Baseline (adaptation disabled)); small intestine: 72.4138% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 56.2814% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 58.0311% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.8785% (minimum 65%, Baseline (adaptation disabled)); stomach: 69.7095% (minimum 70%, Baseline (adaptation disabled)); thymus: 61.7647% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.9474% (minimum 65%, Baseline (adaptation disabled)); tongue: 47.3239% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 69.7095% (minimum 70%, Baseline (adaptation disabled))",-0.0605263,-0.226761,-0.258053,0,80,unavailable,34.7,37.4,23.4,"tongue: 37.4 nTPM (protected, limit 3); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 3); midbrain: 24.3 nTPM (vital, limit 1); spinal cord: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); thymus: 20.8 nTPM (manageable, limit 5); spleen: 20.7 nTPM (manageable, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 3); adipose tissue: 18.7 nTPM (manageable, limit 5); cerebral cortex: 18.7 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 3); colon: 15 nTPM (protected, limit 3); skin: 14.9 nTPM (manageable, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 3); stomach: 14.6 nTPM (protected, limit 3); urinary bladder: 14.6 nTPM (protected, limit 3); rectum: 14.6 nTPM (protected, limit 3); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000255529,POLR2M,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.6977% (minimum 95%, Uncertain); adrenal gland: 83.5714% (minimum 99%, Missing); amygdala: 82.9787% (minimum 99%, Missing); basal ganglia: 79.5918% (minimum 99%, Missing); bone marrow: 86.0294% (minimum 99%, Missing); cerebellum: 96.6942% (minimum 99%, Missing); cerebral cortex: 79.5918% (minimum 99%, Missing); choroid plexus: 40.2062% (minimum 99%, Missing); colon: 92.1260% (minimum 97%, Missing); duodenum: 92.8571% (minimum 99%, Missing); esophagus: 90.6977% (minimum 97%, Missing); heart muscle: 87.9699% (minimum 99%, Missing); hippocampal formation: 82.3944% (minimum 99%, Missing); hypothalamus: 75.9740% (minimum 99%, Missing); kidney: 70.0599% (minimum 99%, Missing); liver: 95.1220% (minimum 99%, Missing); lung: 72.6708% (minimum 99%, Uncertain); lymph node: 90.0000% (minimum 97%, Missing); midbrain: 86.6667% (minimum 99%, Missing); pancreas: 85.4015% (minimum 99%, Missing); parathyroid gland: 58.2090% (minimum 97%, Missing); pituitary gland: 76.9737% (minimum 99%, Missing); rectum: 90.6977% (minimum 97%, Missing); retina: 28.9604% (minimum 99%, Missing); salivary gland: 87.3134% (minimum 97%, Missing); skeletal muscle: 92.1260% (minimum 99%, Missing); skin: 82.3944% (minimum 95%, Missing); small intestine: 92.1260% (minimum 99%, Missing); smooth muscle: 84.7826% (minimum 99%, Missing); spinal cord: 90.6977% (minimum 99%, Missing); spleen: 89.3130% (minimum 95%, Missing); stomach: 90.6977% (minimum 97%, Missing); thymus: 94.3548% (minimum 95%, Missing); thyroid gland: 57.9208% (minimum 95%, Missing); tongue: 93.6000% (minimum 97%, Missing); urinary bladder: 89.3130% (minimum 97%, Missing)",-0.370792,-0.38791,-0.700396,0,3,partial,28.7,8.4,8.5,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 2); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256061,DNAAF4,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 40.2062% (minimum 75%, Missing); kidney: 70.0599% (minimum 75%, Missing); lung: 72.6708% (minimum 75%, Uncertain); parathyroid gland: 58.2090% (minimum 70%, Missing); retina: 28.9604% (minimum 75%, Missing); thyroid gland: 57.9208% (minimum 65%, Missing)",-0.0707921,-0.11791,-0.460396,0,3,partial,28.7,8.4,8.5,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 2); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256061,DNAAF4,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 40.2062% (minimum 75%, Missing); kidney: 70.0599% (minimum 75%, Missing); lung: 72.6708% (minimum 75%, Uncertain); parathyroid gland: 58.2090% (minimum 70%, Missing); retina: 28.9604% (minimum 75%, Missing); thyroid gland: 57.9208% (minimum 65%, Missing)",-0.0707921,-0.11791,-0.460396,0,3,partial,28.7,8.4,8.5,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 3); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256061,DNAAF4,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 40.2062% (minimum 75%, Missing); kidney: 70.0599% (minimum 75%, Missing); lung: 72.6708% (minimum 75%, Uncertain); parathyroid gland: 58.2090% (minimum 70%, Missing); retina: 28.9604% (minimum 75%, Missing); thyroid gland: 57.9208% (minimum 65%, Missing)",-0.0707921,-0.11791,-0.460396,0,3,partial,28.7,8.4,8.5,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 3); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256061,DNAAF4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 40.2062% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.0599% (minimum 75%, Baseline (adaptation disabled)); lung: 72.6708% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 58.2090% (minimum 70%, Baseline (adaptation disabled)); retina: 28.9604% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 57.9208% (minimum 65%, Baseline (adaptation disabled))",-0.0707921,-0.11791,-0.460396,0,3,partial,28.7,8.4,8.5,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 3); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256061,DNAAF4,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.8912% (minimum 95%, Missing); adrenal gland: 62.3978% (minimum 99%, Missing); amygdala: 83.5766% (minimum 99%, Missing); basal ganglia: 82.3741% (minimum 99%, Missing); bone marrow: 72.9299% (minimum 99%, Missing); cerebellum: 77.3649% (minimum 99%, Missing); cerebral cortex: 80.3509% (minimum 99%, Missing); choroid plexus: 66.1850% (minimum 99%, Missing); colon: 68.3582% (minimum 97%, Missing); duodenum: 86.4151% (minimum 99%, Missing); esophagus: 79.7909% (minimum 97%, Missing); heart muscle: 74.1100% (minimum 99%, Missing); hippocampal formation: 83.8828% (minimum 99%, Missing); hypothalamus: 78.9655% (minimum 99%, Missing); kidney: 68.3582% (minimum 99%, Missing); liver: 68.7688% (minimum 99%, Missing); lung: 75.5776% (minimum 99%, Missing); lymph node: 79.7909% (minimum 97%, Missing); midbrain: 84.5018% (minimum 99%, Missing); pancreas: 64.1457% (minimum 99%, Missing); parathyroid gland: 57.6826% (minimum 97%, Missing); pituitary gland: 34.1791% (minimum 99%, Missing); rectum: 79.2388% (minimum 97%, Missing); retina: 64.3258% (minimum 99%, Missing); salivary gland: 74.8366% (minimum 97%, Missing); skeletal muscle: 82.9710% (minimum 99%, Missing); skin: 72.6984% (minimum 95%, Missing); small intestine: 76.8456% (minimum 99%, Missing); smooth muscle: 73.3974% (minimum 99%, Missing); spinal cord: 82.6715% (minimum 99%, Missing); spleen: 79.5139% (minimum 95%, Missing); stomach: 69.1843% (minimum 97%, Missing); thymus: 75.3289% (minimum 95%, Missing); thyroid gland: 52.7650% (minimum 95%, Missing); tongue: 78.9655% (minimum 97%, Missing); urinary bladder: 68.7688% (minimum 97%, Missing)",-0.42235,-0.393174,-0.648209,0,80,unavailable,44.1,16.8,20.5,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (manageable, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 2); kidney: 10.6 nTPM (vital, limit 1); liver: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); stomach: 10.2 nTPM (protected, limit 2); skin: 8.6 nTPM (manageable, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); salivary gland: 7.7 nTPM (protected, limit 2); thymus: 7.5 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 2); rectum: 6 nTPM (protected, limit 2); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 2); esophagus: 5.8 nTPM (protected, limit 2); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256223,ZNF10,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 62.3978% (minimum 75%, Missing); bone marrow: 72.9299% (minimum 75%, Missing); choroid plexus: 66.1850% (minimum 75%, Missing); colon: 68.3582% (minimum 70%, Missing); heart muscle: 74.1100% (minimum 75%, Missing); kidney: 68.3582% (minimum 75%, Missing); liver: 68.7688% (minimum 75%, Missing); pancreas: 64.1457% (minimum 75%, Missing); parathyroid gland: 57.6826% (minimum 70%, Missing); pituitary gland: 34.1791% (minimum 75%, Missing); retina: 64.3258% (minimum 75%, Missing); smooth muscle: 73.3974% (minimum 75%, Missing); stomach: 69.1843% (minimum 70%, Missing); thyroid gland: 52.7650% (minimum 65%, Missing); urinary bladder: 68.7688% (minimum 70%, Missing)",-0.12235,-0.123174,-0.408209,0,80,unavailable,44.1,16.8,20.5,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (manageable, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 2); kidney: 10.6 nTPM (vital, limit 1); liver: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); stomach: 10.2 nTPM (protected, limit 2); skin: 8.6 nTPM (manageable, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); salivary gland: 7.7 nTPM (protected, limit 2); thymus: 7.5 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 2); rectum: 6 nTPM (protected, limit 2); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 2); esophagus: 5.8 nTPM (protected, limit 2); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256223,ZNF10,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 62.3978% (minimum 75%, Missing); bone marrow: 72.9299% (minimum 75%, Missing); choroid plexus: 66.1850% (minimum 75%, Missing); colon: 68.3582% (minimum 70%, Missing); heart muscle: 74.1100% (minimum 75%, Missing); kidney: 68.3582% (minimum 75%, Missing); liver: 68.7688% (minimum 75%, Missing); pancreas: 64.1457% (minimum 75%, Missing); parathyroid gland: 57.6826% (minimum 70%, Missing); pituitary gland: 34.1791% (minimum 75%, Missing); retina: 64.3258% (minimum 75%, Missing); smooth muscle: 73.3974% (minimum 75%, Missing); stomach: 69.1843% (minimum 70%, Missing); thyroid gland: 52.7650% (minimum 65%, Missing); urinary bladder: 68.7688% (minimum 70%, Missing)",-0.12235,-0.123174,-0.408209,0,80,unavailable,44.1,16.8,20.5,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (manageable, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 3); kidney: 10.6 nTPM (vital, limit 1); liver: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); stomach: 10.2 nTPM (protected, limit 3); skin: 8.6 nTPM (manageable, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); salivary gland: 7.7 nTPM (protected, limit 3); thymus: 7.5 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 3); rectum: 6 nTPM (protected, limit 3); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); esophagus: 5.8 nTPM (protected, limit 3); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256223,ZNF10,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 62.3978% (minimum 75%, Missing); bone marrow: 72.9299% (minimum 75%, Missing); choroid plexus: 66.1850% (minimum 75%, Missing); colon: 68.3582% (minimum 70%, Missing); heart muscle: 74.1100% (minimum 75%, Missing); kidney: 68.3582% (minimum 75%, Missing); liver: 68.7688% (minimum 75%, Missing); pancreas: 64.1457% (minimum 75%, Missing); parathyroid gland: 57.6826% (minimum 70%, Missing); pituitary gland: 34.1791% (minimum 75%, Missing); retina: 64.3258% (minimum 75%, Missing); smooth muscle: 73.3974% (minimum 75%, Missing); stomach: 69.1843% (minimum 70%, Missing); thyroid gland: 52.7650% (minimum 65%, Missing); urinary bladder: 68.7688% (minimum 70%, Missing)",-0.12235,-0.123174,-0.408209,0,80,unavailable,44.1,16.8,20.5,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (manageable, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 3); kidney: 10.6 nTPM (vital, limit 1); liver: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); stomach: 10.2 nTPM (protected, limit 3); skin: 8.6 nTPM (manageable, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); salivary gland: 7.7 nTPM (protected, limit 3); thymus: 7.5 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 3); rectum: 6 nTPM (protected, limit 3); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); esophagus: 5.8 nTPM (protected, limit 3); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256223,ZNF10,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 62.3978% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 72.9299% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 66.1850% (minimum 75%, Baseline (adaptation disabled)); colon: 68.3582% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 74.1100% (minimum 75%, Baseline (adaptation disabled)); kidney: 68.3582% (minimum 75%, Baseline (adaptation disabled)); liver: 68.7688% (minimum 75%, Baseline (adaptation disabled)); pancreas: 64.1457% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 57.6826% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 34.1791% (minimum 75%, Baseline (adaptation disabled)); retina: 64.3258% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 73.3974% (minimum 75%, Baseline (adaptation disabled)); stomach: 69.1843% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 52.7650% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 68.7688% (minimum 70%, Baseline (adaptation disabled))",-0.12235,-0.123174,-0.408209,0,80,unavailable,44.1,16.8,20.5,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (manageable, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 3); kidney: 10.6 nTPM (vital, limit 1); liver: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); stomach: 10.2 nTPM (protected, limit 3); skin: 8.6 nTPM (manageable, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); salivary gland: 7.7 nTPM (protected, limit 3); thymus: 7.5 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 3); rectum: 6 nTPM (protected, limit 3); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); esophagus: 5.8 nTPM (protected, limit 3); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256223,ZNF10,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.5172% (minimum 95%, Missing); adrenal gland: 80.0000% (minimum 99%, Missing); amygdala: 88.5714% (minimum 99%, Missing); basal ganglia: 86.1111% (minimum 99%, Missing); bone marrow: 84.3537% (minimum 99%, Missing); cerebellum: 79.4872% (minimum 99%, Missing); cerebral cortex: 78.9809% (minimum 99%, Missing); choroid plexus: 76.5432% (minimum 99%, Missing); colon: 83.7838% (minimum 97%, Missing); duodenum: 83.7838% (minimum 99%, Missing); esophagus: 86.1111% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 87.3239% (minimum 99%, Missing); hypothalamus: 88.5714% (minimum 99%, Missing); kidney: 81.0458% (minimum 99%, Missing); liver: 82.1192% (minimum 99%, Missing); lung: 82.1192% (minimum 99%, Missing); lymph node: 77.5000% (minimum 97%, Missing); midbrain: 87.9433% (minimum 99%, Missing); pancreas: 86.7133% (minimum 99%, Missing); parathyroid gland: 74.2515% (minimum 97%, Missing); pituitary gland: 83.7838% (minimum 99%, Missing); rectum: 83.7838% (minimum 97%, Missing); retina: 64.9215% (minimum 99%, Missing); salivary gland: 80.5195% (minimum 97%, Missing); skeletal muscle: 83.2215% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 85.5172% (minimum 99%, Missing); smooth muscle: 83.7838% (minimum 99%, Missing); spinal cord: 86.1111% (minimum 99%, Missing); spleen: 76.0736% (minimum 95%, Missing); stomach: 81.0458% (minimum 97%, Missing); thymus: 70.8571% (minimum 95%, Missing); thyroid gland: 76.0736% (minimum 95%, Missing); tongue: 84.3537% (minimum 97%, Missing); urinary bladder: 83.2215% (minimum 97%, Missing)",-0.241429,-0.227485,-0.340785,0,80,unavailable,6.7,4.3,5.1,"retina: 6.7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); parathyroid gland: 4.3 nTPM (protected, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256294,ZNF225,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 64.9215% (minimum 75%, Missing)",0.0585714,0.042515,-0.100785,0,80,unavailable,6.7,4.3,5.1,"retina: 6.7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); parathyroid gland: 4.3 nTPM (protected, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256294,ZNF225,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 64.9215% (minimum 75%, Missing)",0.0585714,0.042515,-0.100785,0,80,unavailable,6.7,4.3,5.1,"retina: 6.7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); parathyroid gland: 4.3 nTPM (protected, limit 3); choroid plexus: 3.8 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256294,ZNF225,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 64.9215% (minimum 75%, Missing)",0.0585714,0.042515,-0.100785,0,80,unavailable,6.7,4.3,5.1,"retina: 6.7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); parathyroid gland: 4.3 nTPM (protected, limit 3); choroid plexus: 3.8 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256294,ZNF225,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 64.9215% (minimum 75%, Baseline (adaptation disabled))",0.0585714,0.042515,-0.100785,0,80,unavailable,6.7,4.3,5.1,"retina: 6.7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); parathyroid gland: 4.3 nTPM (protected, limit 3); choroid plexus: 3.8 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256294,ZNF225,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.3333% (minimum 99%, Missing); amygdala: 94.4000% (minimum 99%, Missing); basal ganglia: 91.4729% (minimum 99%, Missing); bone marrow: 98.3333% (minimum 99%, Missing); cerebellum: 79.7297% (minimum 99%, Missing); cerebral cortex: 92.9134% (minimum 99%, Missing); choroid plexus: 90.0763% (minimum 99%, Missing); colon: 96.7213% (minimum 97%, Missing); heart muscle: 96.7213% (minimum 99%, Missing); hippocampal formation: 94.4000% (minimum 99%, Missing); hypothalamus: 94.4000% (minimum 99%, Missing); kidney: 92.1875% (minimum 99%, Missing); liver: 92.1875% (minimum 99%, Missing); lung: 95.1613% (minimum 99%, Missing); midbrain: 95.1613% (minimum 99%, Missing); pancreas: 94.4000% (minimum 99%, Missing); parathyroid gland: 96.7213% (minimum 97%, Missing); pituitary gland: 90.7692% (minimum 99%, Missing); skeletal muscle: 94.4000% (minimum 99%, Missing); small intestine: 95.1613% (minimum 99%, Missing); smooth muscle: 98.3333% (minimum 99%, Missing); spinal cord: 94.4000% (minimum 99%, Missing); spleen: 92.1875% (minimum 95%, Missing)",-0.028125,-0.00278689,-0.192703,0,80,unavailable,3,0.4,1,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256453,DND1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.271875,0.267213,0.0472973,0,80,unavailable,3,0.4,1,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256453,DND1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.271875,0.267213,0.0472973,0,80,unavailable,3,0.4,1,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256453,DND1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.271875,0.267213,0.0472973,0,80,unavailable,3,0.4,1,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256453,DND1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.271875,0.267213,0.0472973,0,80,unavailable,3,0.4,1,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256453,DND1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 70.6522% (minimum 99%, Missing); choroid plexus: 96.2963% (minimum 99%, Missing); liver: 98.4848% (minimum 99%, Missing); lung: 94.8905% (minimum 99%, Missing); midbrain: 98.4848% (minimum 99%, Missing); skin: 75.1445% (minimum 95%, Missing); spleen: 89.6552% (minimum 95%, Missing)",-0.198555,0.0223664,-0.283478,0,80,unavailable,5.4,0.1,4.3,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256660,CLEC12B,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 70.6522% (minimum 75%, Missing)",0.101445,0.292366,-0.0434783,0,80,unavailable,5.4,0.1,4.3,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256660,CLEC12B,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 70.6522% (minimum 75%, Missing)",0.101445,0.292366,-0.0434783,0,80,unavailable,5.4,0.1,4.3,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256660,CLEC12B,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 70.6522% (minimum 75%, Missing)",0.101445,0.292366,-0.0434783,0,80,unavailable,5.4,0.1,4.3,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256660,CLEC12B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 70.6522% (minimum 75%, Baseline (adaptation disabled))",0.101445,0.292366,-0.0434783,0,80,unavailable,5.4,0.1,4.3,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256660,CLEC12B,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 80.5970% (minimum 99%, Missing); basal ganglia: 40.0000% (minimum 99%, Missing); bone marrow: 96.4286% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); cerebral cortex: 84.3750% (minimum 99%, Missing); hippocampal formation: 87.0968% (minimum 99%, Missing); hypothalamus: 87.0968% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); midbrain: 83.0769% (minimum 99%, Missing); pancreas: 98.1818% (minimum 99%, Missing); pituitary gland: 78.2609% (minimum 99%, Missing); retina: 91.5254% (minimum 99%, Missing); spinal cord: 91.5254% (minimum 99%, Missing); thymus: 93.1034% (minimum 95%, Missing)",-0.0189655,0.0118182,-0.59,0,80,unavailable,8.1,0.1,0.4,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256980,KHDC1L,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 40.0000% (minimum 75%, Missing)",0.281034,0.281818,-0.35,0,80,unavailable,8.1,0.1,0.4,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256980,KHDC1L,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 40.0000% (minimum 75%, Missing)",0.281034,0.281818,-0.35,0,80,unavailable,8.1,0.1,0.4,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256980,KHDC1L,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 40.0000% (minimum 75%, Missing)",0.281034,0.281818,-0.35,0,80,unavailable,8.1,0.1,0.4,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256980,KHDC1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 40.0000% (minimum 75%, Baseline (adaptation disabled))",0.281034,0.281818,-0.35,0,80,unavailable,8.1,0.1,0.4,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000256980,KHDC1L,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 95%, Missing); adrenal gland: 53.7037% (minimum 99%, Missing); amygdala: 53.9535% (minimum 99%, Missing); basal ganglia: 56.0386% (minimum 99%, Missing); bone marrow: 61.3757% (minimum 99%, Missing); cerebellum: 43.6090% (minimum 99%, Missing); cerebral cortex: 50.6550% (minimum 99%, Missing); choroid plexus: 58.8832% (minimum 99%, Missing); colon: 54.2056% (minimum 97%, Missing); duodenum: 50.4348% (minimum 99%, Missing); esophagus: 57.7114% (minimum 97%, Missing); heart muscle: 64.4444% (minimum 99%, Missing); hippocampal formation: 51.3274% (minimum 99%, Missing); hypothalamus: 53.7037% (minimum 99%, Missing); kidney: 44.1065% (minimum 99%, Missing); liver: 42.3358% (minimum 99%, Missing); lung: 58.2915% (minimum 99%, Missing); lymph node: 53.9535% (minimum 97%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 24.0166% (minimum 99%, Missing); parathyroid gland: 47.9339% (minimum 97%, Missing); pituitary gland: 60.1036% (minimum 99%, Missing); rectum: 52.9680% (minimum 97%, Missing); retina: 48.3333% (minimum 99%, Missing); salivary gland: 53.4562% (minimum 97%, Missing); skeletal muscle: 58.5859% (minimum 99%, Missing); skin: 55.7692% (minimum 95%, Missing); small intestine: 53.9535% (minimum 99%, Missing); smooth muscle: 60.7330% (minimum 99%, Missing); spinal cord: 43.2836% (minimum 99%, Missing); spleen: 56.3107% (minimum 95%, Missing); stomach: 55.5024% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing); thyroid gland: 50.8772% (minimum 95%, Missing); tongue: 60.1036% (minimum 97%, Missing); urinary bladder: 54.7170% (minimum 97%, Missing)",-0.45,-0.490661,-0.749834,0,80,unavailable,36.7,12.6,11.6,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 2); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); thymus: 11.6 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 2); salivary gland: 10.1 nTPM (protected, limit 2); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 2); amygdala: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 2); adipose tissue: 9.7 nTPM (manageable, limit 5); urinary bladder: 9.6 nTPM (protected, limit 2); stomach: 9.3 nTPM (protected, limit 2); skin: 9.2 nTPM (manageable, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); esophagus: 8.5 nTPM (protected, limit 2); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000257218,GATC,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 65%, Missing); adrenal gland: 53.7037% (minimum 75%, Missing); amygdala: 53.9535% (minimum 75%, Missing); basal ganglia: 56.0386% (minimum 75%, Missing); bone marrow: 61.3757% (minimum 75%, Missing); cerebellum: 43.6090% (minimum 75%, Missing); cerebral cortex: 50.6550% (minimum 75%, Missing); choroid plexus: 58.8832% (minimum 75%, Missing); colon: 54.2056% (minimum 70%, Missing); duodenum: 50.4348% (minimum 75%, Missing); esophagus: 57.7114% (minimum 70%, Missing); heart muscle: 64.4444% (minimum 75%, Missing); hippocampal formation: 51.3274% (minimum 75%, Missing); hypothalamus: 53.7037% (minimum 75%, Missing); kidney: 44.1065% (minimum 75%, Missing); liver: 42.3358% (minimum 75%, Missing); lung: 58.2915% (minimum 75%, Missing); lymph node: 53.9535% (minimum 70%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 24.0166% (minimum 75%, Missing); parathyroid gland: 47.9339% (minimum 70%, Missing); pituitary gland: 60.1036% (minimum 75%, Missing); rectum: 52.9680% (minimum 70%, Missing); retina: 48.3333% (minimum 75%, Missing); salivary gland: 53.4562% (minimum 70%, Missing); skeletal muscle: 58.5859% (minimum 75%, Missing); skin: 55.7692% (minimum 65%, Missing); small intestine: 53.9535% (minimum 75%, Missing); smooth muscle: 60.7330% (minimum 75%, Missing); spinal cord: 43.2836% (minimum 75%, Missing); spleen: 56.3107% (minimum 65%, Missing); stomach: 55.5024% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 50.8772% (minimum 65%, Missing); tongue: 60.1036% (minimum 70%, Missing); urinary bladder: 54.7170% (minimum 70%, Missing)",-0.15,-0.220661,-0.509834,0,80,unavailable,36.7,12.6,11.6,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 2); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); thymus: 11.6 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 2); salivary gland: 10.1 nTPM (protected, limit 2); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 2); amygdala: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 2); adipose tissue: 9.7 nTPM (manageable, limit 5); urinary bladder: 9.6 nTPM (protected, limit 2); stomach: 9.3 nTPM (protected, limit 2); skin: 9.2 nTPM (manageable, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); esophagus: 8.5 nTPM (protected, limit 2); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000257218,GATC,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 65%, Missing); adrenal gland: 53.7037% (minimum 75%, Missing); amygdala: 53.9535% (minimum 75%, Missing); basal ganglia: 56.0386% (minimum 75%, Missing); bone marrow: 61.3757% (minimum 75%, Missing); cerebellum: 43.6090% (minimum 75%, Missing); cerebral cortex: 50.6550% (minimum 75%, Missing); choroid plexus: 58.8832% (minimum 75%, Missing); colon: 54.2056% (minimum 70%, Missing); duodenum: 50.4348% (minimum 75%, Missing); esophagus: 57.7114% (minimum 70%, Missing); heart muscle: 64.4444% (minimum 75%, Missing); hippocampal formation: 51.3274% (minimum 75%, Missing); hypothalamus: 53.7037% (minimum 75%, Missing); kidney: 44.1065% (minimum 75%, Missing); liver: 42.3358% (minimum 75%, Missing); lung: 58.2915% (minimum 75%, Missing); lymph node: 53.9535% (minimum 70%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 24.0166% (minimum 75%, Missing); parathyroid gland: 47.9339% (minimum 70%, Missing); pituitary gland: 60.1036% (minimum 75%, Missing); rectum: 52.9680% (minimum 70%, Missing); retina: 48.3333% (minimum 75%, Missing); salivary gland: 53.4562% (minimum 70%, Missing); skeletal muscle: 58.5859% (minimum 75%, Missing); skin: 55.7692% (minimum 65%, Missing); small intestine: 53.9535% (minimum 75%, Missing); smooth muscle: 60.7330% (minimum 75%, Missing); spinal cord: 43.2836% (minimum 75%, Missing); spleen: 56.3107% (minimum 65%, Missing); stomach: 55.5024% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 50.8772% (minimum 65%, Missing); tongue: 60.1036% (minimum 70%, Missing); urinary bladder: 54.7170% (minimum 70%, Missing)",-0.15,-0.220661,-0.509834,0,80,unavailable,36.7,12.6,11.6,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 3); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); thymus: 11.6 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 3); salivary gland: 10.1 nTPM (protected, limit 3); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 3); amygdala: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 3); adipose tissue: 9.7 nTPM (manageable, limit 5); urinary bladder: 9.6 nTPM (protected, limit 3); stomach: 9.3 nTPM (protected, limit 3); skin: 9.2 nTPM (manageable, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); esophagus: 8.5 nTPM (protected, limit 3); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000257218,GATC,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 65%, Missing); adrenal gland: 53.7037% (minimum 75%, Missing); amygdala: 53.9535% (minimum 75%, Missing); basal ganglia: 56.0386% (minimum 75%, Missing); bone marrow: 61.3757% (minimum 75%, Missing); cerebellum: 43.6090% (minimum 75%, Missing); cerebral cortex: 50.6550% (minimum 75%, Missing); choroid plexus: 58.8832% (minimum 75%, Missing); colon: 54.2056% (minimum 70%, Missing); duodenum: 50.4348% (minimum 75%, Missing); esophagus: 57.7114% (minimum 70%, Missing); heart muscle: 64.4444% (minimum 75%, Missing); hippocampal formation: 51.3274% (minimum 75%, Missing); hypothalamus: 53.7037% (minimum 75%, Missing); kidney: 44.1065% (minimum 75%, Missing); liver: 42.3358% (minimum 75%, Missing); lung: 58.2915% (minimum 75%, Missing); lymph node: 53.9535% (minimum 70%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 24.0166% (minimum 75%, Missing); parathyroid gland: 47.9339% (minimum 70%, Missing); pituitary gland: 60.1036% (minimum 75%, Missing); rectum: 52.9680% (minimum 70%, Missing); retina: 48.3333% (minimum 75%, Missing); salivary gland: 53.4562% (minimum 70%, Missing); skeletal muscle: 58.5859% (minimum 75%, Missing); skin: 55.7692% (minimum 65%, Missing); small intestine: 53.9535% (minimum 75%, Missing); smooth muscle: 60.7330% (minimum 75%, Missing); spinal cord: 43.2836% (minimum 75%, Missing); spleen: 56.3107% (minimum 65%, Missing); stomach: 55.5024% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 50.8772% (minimum 65%, Missing); tongue: 60.1036% (minimum 70%, Missing); urinary bladder: 54.7170% (minimum 70%, Missing)",-0.15,-0.220661,-0.509834,0,80,unavailable,36.7,12.6,11.6,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 3); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); thymus: 11.6 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 3); salivary gland: 10.1 nTPM (protected, limit 3); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 3); amygdala: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 3); adipose tissue: 9.7 nTPM (manageable, limit 5); urinary bladder: 9.6 nTPM (protected, limit 3); stomach: 9.3 nTPM (protected, limit 3); skin: 9.2 nTPM (manageable, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); esophagus: 8.5 nTPM (protected, limit 3); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000257218,GATC,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 53.7037% (minimum 75%, Baseline (adaptation disabled)); amygdala: 53.9535% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 56.0386% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 61.3757% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 43.6090% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 50.6550% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.8832% (minimum 75%, Baseline (adaptation disabled)); colon: 54.2056% (minimum 70%, Baseline (adaptation disabled)); duodenum: 50.4348% (minimum 75%, Baseline (adaptation disabled)); esophagus: 57.7114% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 64.4444% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 51.3274% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 53.7037% (minimum 75%, Baseline (adaptation disabled)); kidney: 44.1065% (minimum 75%, Baseline (adaptation disabled)); liver: 42.3358% (minimum 75%, Baseline (adaptation disabled)); lung: 58.2915% (minimum 75%, Baseline (adaptation disabled)); lymph node: 53.9535% (minimum 70%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 24.0166% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 47.9339% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 60.1036% (minimum 75%, Baseline (adaptation disabled)); rectum: 52.9680% (minimum 70%, Baseline (adaptation disabled)); retina: 48.3333% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 53.4562% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 58.5859% (minimum 75%, Baseline (adaptation disabled)); skin: 55.7692% (minimum 65%, Baseline (adaptation disabled)); small intestine: 53.9535% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.7330% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 43.2836% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.3107% (minimum 65%, Baseline (adaptation disabled)); stomach: 55.5024% (minimum 70%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 50.8772% (minimum 65%, Baseline (adaptation disabled)); tongue: 60.1036% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 54.7170% (minimum 70%, Baseline (adaptation disabled))",-0.15,-0.220661,-0.509834,0,80,unavailable,36.7,12.6,11.6,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 3); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); thymus: 11.6 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 3); salivary gland: 10.1 nTPM (protected, limit 3); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 3); amygdala: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 3); adipose tissue: 9.7 nTPM (manageable, limit 5); urinary bladder: 9.6 nTPM (protected, limit 3); stomach: 9.3 nTPM (protected, limit 3); skin: 9.2 nTPM (manageable, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); esophagus: 8.5 nTPM (protected, limit 3); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000257218,GATC,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"stomach: 94.8357% (minimum 97%, Missing)",0.05,-0.0216432,0.000196078,0,80,unavailable,0.2,1.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000257987,SPMIP11,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.248357,0.240196,0,80,unavailable,0.2,1.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000257987,SPMIP11,selectivity_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.248357,0.240196,0,80,unavailable,0.2,1.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000257987,SPMIP11,grid_revised,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.248357,0.240196,0,80,unavailable,0.2,1.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000257987,SPMIP11,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.248357,0.240196,0,80,unavailable,0.2,1.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000257987,SPMIP11,current_fixed,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.0460317,0.03,0.00603175,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258223,PRSS58,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346032,0.3,0.246032,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258223,PRSS58,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346032,0.3,0.246032,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258223,PRSS58,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346032,0.3,0.246032,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258223,PRSS58,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.346032,0.3,0.246032,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258223,PRSS58,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.8538% (minimum 95%, Missing); adrenal gland: 57.1279% (minimum 99%, Missing); amygdala: 62.5000% (minimum 99%, Missing); basal ganglia: 65.3477% (minimum 99%, Missing); bone marrow: 56.0123% (minimum 99%, Missing); cerebellum: 74.6575% (minimum 99%, Missing); cerebral cortex: 63.2985% (minimum 99%, Missing); choroid plexus: 57.4289% (minimum 99%, Missing); colon: 56.3017% (minimum 97%, Missing); duodenum: 64.8038% (minimum 99%, Missing); esophagus: 62.5000% (minimum 97%, Missing); heart muscle: 48.9228% (minimum 99%, Missing); hippocampal formation: 63.8921% (minimum 99%, Missing); hypothalamus: 63.9671% (minimum 99%, Missing); kidney: 62.2146% (minimum 99%, Missing); liver: 51.6098% (minimum 99%, Missing); lung: 65.7419% (minimum 99%, Missing); lymph node: 56.5940% (minimum 97%, Missing); midbrain: 59.3036% (minimum 99%, Missing); pancreas: 65.0358% (minimum 99%, Missing); parathyroid gland: 55.2178% (minimum 97%, Missing); pituitary gland: 68.9001% (minimum 99%, Missing); rectum: 60.5556% (minimum 97%, Missing); retina: 60.3544% (minimum 99%, Missing); salivary gland: 67.9551% (minimum 97%, Missing); skeletal muscle: 40.5204% (minimum 99%, Missing); skin: 65.1135% (minimum 95%, Missing); small intestine: 63.0787% (minimum 99%, Missing); smooth muscle: 54.8290% (minimum 99%, Missing); spinal cord: 52.6570% (minimum 99%, Missing); spleen: 57.1279% (minimum 90%, Approved); stomach: 62.5000% (minimum 97%, Missing); thymus: 47.9332% (minimum 95%, Missing); thyroid gland: 63.8921% (minimum 95%, Missing); tongue: 51.2700% (minimum 97%, Missing); urinary bladder: 59.5628% (minimum 97%, Missing)",-0.470668,-0.4573,-0.584796,0,6,partial,80,51.8,59.2,"skeletal muscle: 80 nTPM (vital, limit 1); thymus: 59.2 nTPM (manageable, limit 5); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 2); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (manageable, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 2); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 2); lymph node: 41.8 nTPM (protected, limit 2); spleen: 40.9 nTPM (manageable, limit 10); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 2); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 2); kidney: 33.1 nTPM (vital, limit 1); stomach: 32.7 nTPM (protected, limit 2); amygdala: 32.7 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 2); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (manageable, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); skin: 29.2 nTPM (manageable, limit 5); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); salivary gland: 25.7 nTPM (protected, limit 2); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258289,CHURC1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.8538% (minimum 65%, Missing); adrenal gland: 57.1279% (minimum 75%, Missing); amygdala: 62.5000% (minimum 75%, Missing); basal ganglia: 65.3477% (minimum 75%, Missing); bone marrow: 56.0123% (minimum 75%, Missing); cerebellum: 74.6575% (minimum 75%, Missing); cerebral cortex: 63.2985% (minimum 75%, Missing); choroid plexus: 57.4289% (minimum 75%, Missing); colon: 56.3017% (minimum 70%, Missing); duodenum: 64.8038% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); heart muscle: 48.9228% (minimum 75%, Missing); hippocampal formation: 63.8921% (minimum 75%, Missing); hypothalamus: 63.9671% (minimum 75%, Missing); kidney: 62.2146% (minimum 75%, Missing); liver: 51.6098% (minimum 75%, Missing); lung: 65.7419% (minimum 75%, Missing); lymph node: 56.5940% (minimum 70%, Missing); midbrain: 59.3036% (minimum 75%, Missing); pancreas: 65.0358% (minimum 75%, Missing); parathyroid gland: 55.2178% (minimum 70%, Missing); pituitary gland: 68.9001% (minimum 75%, Missing); rectum: 60.5556% (minimum 70%, Missing); retina: 60.3544% (minimum 75%, Missing); salivary gland: 67.9551% (minimum 70%, Missing); skeletal muscle: 40.5204% (minimum 75%, Missing); small intestine: 63.0787% (minimum 75%, Missing); smooth muscle: 54.8290% (minimum 75%, Missing); spinal cord: 52.6570% (minimum 75%, Missing); spleen: 57.1279% (minimum 60%, Approved); stomach: 62.5000% (minimum 70%, Missing); thymus: 47.9332% (minimum 65%, Missing); thyroid gland: 63.8921% (minimum 65%, Missing); tongue: 51.2700% (minimum 70%, Missing); urinary bladder: 59.5628% (minimum 70%, Missing)",-0.170668,-0.1873,-0.344796,0,6,partial,80,51.8,59.2,"skeletal muscle: 80 nTPM (vital, limit 1); thymus: 59.2 nTPM (manageable, limit 5); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 2); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (manageable, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 2); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 2); lymph node: 41.8 nTPM (protected, limit 2); spleen: 40.9 nTPM (manageable, limit 10); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 2); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 2); kidney: 33.1 nTPM (vital, limit 1); stomach: 32.7 nTPM (protected, limit 2); amygdala: 32.7 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 2); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (manageable, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); skin: 29.2 nTPM (manageable, limit 5); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); salivary gland: 25.7 nTPM (protected, limit 2); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258289,CHURC1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.8538% (minimum 65%, Missing); adrenal gland: 57.1279% (minimum 75%, Missing); amygdala: 62.5000% (minimum 75%, Missing); basal ganglia: 65.3477% (minimum 75%, Missing); bone marrow: 56.0123% (minimum 75%, Missing); cerebellum: 74.6575% (minimum 75%, Missing); cerebral cortex: 63.2985% (minimum 75%, Missing); choroid plexus: 57.4289% (minimum 75%, Missing); colon: 56.3017% (minimum 70%, Missing); duodenum: 64.8038% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); heart muscle: 48.9228% (minimum 75%, Missing); hippocampal formation: 63.8921% (minimum 75%, Missing); hypothalamus: 63.9671% (minimum 75%, Missing); kidney: 62.2146% (minimum 75%, Missing); liver: 51.6098% (minimum 75%, Missing); lung: 65.7419% (minimum 75%, Missing); lymph node: 56.5940% (minimum 70%, Missing); midbrain: 59.3036% (minimum 75%, Missing); pancreas: 65.0358% (minimum 75%, Missing); parathyroid gland: 55.2178% (minimum 70%, Missing); pituitary gland: 68.9001% (minimum 75%, Missing); rectum: 60.5556% (minimum 70%, Missing); retina: 60.3544% (minimum 75%, Missing); salivary gland: 67.9551% (minimum 70%, Missing); skeletal muscle: 40.5204% (minimum 75%, Missing); small intestine: 63.0787% (minimum 75%, Missing); smooth muscle: 54.8290% (minimum 75%, Missing); spinal cord: 52.6570% (minimum 75%, Missing); spleen: 57.1279% (minimum 60%, Approved); stomach: 62.5000% (minimum 70%, Missing); thymus: 47.9332% (minimum 65%, Missing); thyroid gland: 63.8921% (minimum 65%, Missing); tongue: 51.2700% (minimum 70%, Missing); urinary bladder: 59.5628% (minimum 70%, Missing)",-0.170668,-0.1873,-0.344796,0,6,partial,80,51.8,59.2,"skeletal muscle: 80 nTPM (vital, limit 1); thymus: 59.2 nTPM (manageable, limit 5); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 3); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (manageable, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 3); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 3); lymph node: 41.8 nTPM (protected, limit 3); spleen: 40.9 nTPM (manageable, limit 10); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 3); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 3); kidney: 33.1 nTPM (vital, limit 1); stomach: 32.7 nTPM (protected, limit 3); amygdala: 32.7 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 3); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (manageable, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); skin: 29.2 nTPM (manageable, limit 5); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); salivary gland: 25.7 nTPM (protected, limit 3); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258289,CHURC1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.8538% (minimum 65%, Missing); adrenal gland: 57.1279% (minimum 75%, Missing); amygdala: 62.5000% (minimum 75%, Missing); basal ganglia: 65.3477% (minimum 75%, Missing); bone marrow: 56.0123% (minimum 75%, Missing); cerebellum: 74.6575% (minimum 75%, Missing); cerebral cortex: 63.2985% (minimum 75%, Missing); choroid plexus: 57.4289% (minimum 75%, Missing); colon: 56.3017% (minimum 70%, Missing); duodenum: 64.8038% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); heart muscle: 48.9228% (minimum 75%, Missing); hippocampal formation: 63.8921% (minimum 75%, Missing); hypothalamus: 63.9671% (minimum 75%, Missing); kidney: 62.2146% (minimum 75%, Missing); liver: 51.6098% (minimum 75%, Missing); lung: 65.7419% (minimum 75%, Missing); lymph node: 56.5940% (minimum 70%, Missing); midbrain: 59.3036% (minimum 75%, Missing); pancreas: 65.0358% (minimum 75%, Missing); parathyroid gland: 55.2178% (minimum 70%, Missing); pituitary gland: 68.9001% (minimum 75%, Missing); rectum: 60.5556% (minimum 70%, Missing); retina: 60.3544% (minimum 75%, Missing); salivary gland: 67.9551% (minimum 70%, Missing); skeletal muscle: 40.5204% (minimum 75%, Missing); small intestine: 63.0787% (minimum 75%, Missing); smooth muscle: 54.8290% (minimum 75%, Missing); spinal cord: 52.6570% (minimum 75%, Missing); spleen: 57.1279% (minimum 60%, Approved); stomach: 62.5000% (minimum 70%, Missing); thymus: 47.9332% (minimum 65%, Missing); thyroid gland: 63.8921% (minimum 65%, Missing); tongue: 51.2700% (minimum 70%, Missing); urinary bladder: 59.5628% (minimum 70%, Missing)",-0.170668,-0.1873,-0.344796,0,6,partial,80,51.8,59.2,"skeletal muscle: 80 nTPM (vital, limit 1); thymus: 59.2 nTPM (manageable, limit 5); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 3); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (manageable, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 3); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 3); lymph node: 41.8 nTPM (protected, limit 3); spleen: 40.9 nTPM (manageable, limit 10); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 3); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 3); kidney: 33.1 nTPM (vital, limit 1); stomach: 32.7 nTPM (protected, limit 3); amygdala: 32.7 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 3); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (manageable, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); skin: 29.2 nTPM (manageable, limit 5); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); salivary gland: 25.7 nTPM (protected, limit 3); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258289,CHURC1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.8538% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 57.1279% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.5000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 65.3477% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 56.0123% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 74.6575% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.2985% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 57.4289% (minimum 75%, Baseline (adaptation disabled)); colon: 56.3017% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.8038% (minimum 75%, Baseline (adaptation disabled)); esophagus: 62.5000% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 48.9228% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 63.8921% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 63.9671% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.2146% (minimum 75%, Baseline (adaptation disabled)); liver: 51.6098% (minimum 75%, Baseline (adaptation disabled)); lung: 65.7419% (minimum 75%, Baseline (adaptation disabled)); lymph node: 56.5940% (minimum 70%, Baseline (adaptation disabled)); midbrain: 59.3036% (minimum 75%, Baseline (adaptation disabled)); pancreas: 65.0358% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 55.2178% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 68.9001% (minimum 75%, Baseline (adaptation disabled)); rectum: 60.5556% (minimum 70%, Baseline (adaptation disabled)); retina: 60.3544% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 67.9551% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 40.5204% (minimum 75%, Baseline (adaptation disabled)); small intestine: 63.0787% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 54.8290% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 52.6570% (minimum 75%, Baseline (adaptation disabled)); spleen: 57.1279% (minimum 65%, Baseline (adaptation disabled)); stomach: 62.5000% (minimum 70%, Baseline (adaptation disabled)); thymus: 47.9332% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 63.8921% (minimum 65%, Baseline (adaptation disabled)); tongue: 51.2700% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 59.5628% (minimum 70%, Baseline (adaptation disabled))",-0.170668,-0.1873,-0.344796,0,6,partial,80,51.8,59.2,"skeletal muscle: 80 nTPM (vital, limit 1); thymus: 59.2 nTPM (manageable, limit 5); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 3); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (manageable, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 3); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 3); lymph node: 41.8 nTPM (protected, limit 3); spleen: 40.9 nTPM (manageable, limit 5); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 3); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 3); kidney: 33.1 nTPM (vital, limit 1); stomach: 32.7 nTPM (protected, limit 3); amygdala: 32.7 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 3); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (manageable, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); skin: 29.2 nTPM (manageable, limit 5); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); salivary gland: 25.7 nTPM (protected, limit 3); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258289,CHURC1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.1329% (minimum 95%, Missing); adrenal gland: 58.5366% (minimum 99%, Missing); amygdala: 83.4783% (minimum 99%, Missing); basal ganglia: 75.5906% (minimum 99%, Missing); bone marrow: 64.8649% (minimum 99%, Missing); cerebellum: 39.8340% (minimum 99%, Missing); cerebral cortex: 61.9355% (minimum 99%, Missing); choroid plexus: 80.0000% (minimum 99%, Missing); colon: 53.6313% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 68.0851% (minimum 97%, Missing); heart muscle: 71.6418% (minimum 99%, Missing); hippocampal formation: 80.6723% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 70.5882% (minimum 99%, Missing); liver: 67.1329% (minimum 99%, Missing); lung: 62.3377% (minimum 99%, Missing); lymph node: 78.0488% (minimum 97%, Missing); midbrain: 84.2105% (minimum 99%, Missing); pancreas: 61.5385% (minimum 99%, Missing); parathyroid gland: 80.6723% (minimum 97%, Missing); pituitary gland: 44.6512% (minimum 99%, Missing); rectum: 89.7196% (minimum 97%, Missing); retina: 86.4865% (minimum 99%, Missing); salivary gland: 63.1579% (minimum 97%, Missing); skeletal muscle: 68.0851% (minimum 99%, Missing); skin: 68.5714% (minimum 95%, Missing); small intestine: 62.7451% (minimum 99%, Missing); smooth muscle: 86.4865% (minimum 99%, Missing); spinal cord: 82.7586% (minimum 99%, Missing); spleen: 61.9355% (minimum 95%, Missing); stomach: 60.0000% (minimum 97%, Missing); thymus: 74.4186% (minimum 95%, Missing); thyroid gland: 55.8140% (minimum 95%, Missing); tongue: 87.2727% (minimum 97%, Missing); urinary bladder: 60.3774% (minimum 97%, Missing)",-0.39186,-0.433687,-0.59166,0,80,unavailable,14.5,8.3,7.6,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 2); urinary bladder: 6.3 nTPM (protected, limit 2); pancreas: 6 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); cerebral cortex: 5.9 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258366,RTEL1,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.5366% (minimum 75%, Missing); bone marrow: 64.8649% (minimum 75%, Missing); cerebellum: 39.8340% (minimum 75%, Missing); cerebral cortex: 61.9355% (minimum 75%, Missing); colon: 53.6313% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); esophagus: 68.0851% (minimum 70%, Missing); heart muscle: 71.6418% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); kidney: 70.5882% (minimum 75%, Missing); liver: 67.1329% (minimum 75%, Missing); lung: 62.3377% (minimum 75%, Missing); pancreas: 61.5385% (minimum 75%, Missing); pituitary gland: 44.6512% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skeletal muscle: 68.0851% (minimum 75%, Missing); small intestine: 62.7451% (minimum 75%, Missing); spleen: 61.9355% (minimum 65%, Missing); stomach: 60.0000% (minimum 70%, Missing); thyroid gland: 55.8140% (minimum 65%, Missing); urinary bladder: 60.3774% (minimum 70%, Missing)",-0.0918605,-0.163687,-0.35166,0,80,unavailable,14.5,8.3,7.6,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 2); urinary bladder: 6.3 nTPM (protected, limit 2); pancreas: 6 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); cerebral cortex: 5.9 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258366,RTEL1,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.5366% (minimum 75%, Missing); bone marrow: 64.8649% (minimum 75%, Missing); cerebellum: 39.8340% (minimum 75%, Missing); cerebral cortex: 61.9355% (minimum 75%, Missing); colon: 53.6313% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); esophagus: 68.0851% (minimum 70%, Missing); heart muscle: 71.6418% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); kidney: 70.5882% (minimum 75%, Missing); liver: 67.1329% (minimum 75%, Missing); lung: 62.3377% (minimum 75%, Missing); pancreas: 61.5385% (minimum 75%, Missing); pituitary gland: 44.6512% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skeletal muscle: 68.0851% (minimum 75%, Missing); small intestine: 62.7451% (minimum 75%, Missing); spleen: 61.9355% (minimum 65%, Missing); stomach: 60.0000% (minimum 70%, Missing); thyroid gland: 55.8140% (minimum 65%, Missing); urinary bladder: 60.3774% (minimum 70%, Missing)",-0.0918605,-0.163687,-0.35166,0,80,unavailable,14.5,8.3,7.6,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 3); thyroid gland: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 3); urinary bladder: 6.3 nTPM (protected, limit 3); pancreas: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258366,RTEL1,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.5366% (minimum 75%, Missing); bone marrow: 64.8649% (minimum 75%, Missing); cerebellum: 39.8340% (minimum 75%, Missing); cerebral cortex: 61.9355% (minimum 75%, Missing); colon: 53.6313% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); esophagus: 68.0851% (minimum 70%, Missing); heart muscle: 71.6418% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); kidney: 70.5882% (minimum 75%, Missing); liver: 67.1329% (minimum 75%, Missing); lung: 62.3377% (minimum 75%, Missing); pancreas: 61.5385% (minimum 75%, Missing); pituitary gland: 44.6512% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skeletal muscle: 68.0851% (minimum 75%, Missing); small intestine: 62.7451% (minimum 75%, Missing); spleen: 61.9355% (minimum 65%, Missing); stomach: 60.0000% (minimum 70%, Missing); thyroid gland: 55.8140% (minimum 65%, Missing); urinary bladder: 60.3774% (minimum 70%, Missing)",-0.0918605,-0.163687,-0.35166,0,80,unavailable,14.5,8.3,7.6,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 3); thyroid gland: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 3); urinary bladder: 6.3 nTPM (protected, limit 3); pancreas: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258366,RTEL1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.5366% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 64.8649% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 39.8340% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.9355% (minimum 75%, Baseline (adaptation disabled)); colon: 53.6313% (minimum 70%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 75%, Baseline (adaptation disabled)); esophagus: 68.0851% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 71.6418% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 70.5882% (minimum 75%, Baseline (adaptation disabled)); liver: 67.1329% (minimum 75%, Baseline (adaptation disabled)); lung: 62.3377% (minimum 75%, Baseline (adaptation disabled)); pancreas: 61.5385% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 44.6512% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 63.1579% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 68.0851% (minimum 75%, Baseline (adaptation disabled)); small intestine: 62.7451% (minimum 75%, Baseline (adaptation disabled)); spleen: 61.9355% (minimum 65%, Baseline (adaptation disabled)); stomach: 60.0000% (minimum 70%, Baseline (adaptation disabled)); thyroid gland: 55.8140% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 60.3774% (minimum 70%, Baseline (adaptation disabled))",-0.0918605,-0.163687,-0.35166,0,80,unavailable,14.5,8.3,7.6,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 3); thyroid gland: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 3); urinary bladder: 6.3 nTPM (protected, limit 3); pancreas: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258366,RTEL1,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.8551% (minimum 95%, Missing); adrenal gland: 91.1765% (minimum 99%, Missing); amygdala: 95.3846% (minimum 99%, Missing); basal ganglia: 91.1765% (minimum 99%, Missing); bone marrow: 88.5714% (minimum 99%, Missing); cerebellum: 92.5373% (minimum 99%, Missing); cerebral cortex: 81.5789% (minimum 99%, Missing); choroid plexus: 89.8551% (minimum 99%, Missing); colon: 92.5373% (minimum 97%, Missing); duodenum: 93.9394% (minimum 99%, Missing); esophagus: 93.9394% (minimum 97%, Missing); heart muscle: 84.9315% (minimum 99%, Missing); hippocampal formation: 95.3846% (minimum 99%, Missing); hypothalamus: 95.3846% (minimum 99%, Missing); kidney: 87.3239% (minimum 99%, Missing); liver: 95.3846% (minimum 99%, Missing); lung: 89.8551% (minimum 99%, Missing); lymph node: 89.8551% (minimum 97%, Missing); midbrain: 96.8750% (minimum 99%, Missing); pancreas: 89.8551% (minimum 99%, Missing); parathyroid gland: 86.1111% (minimum 97%, Missing); pituitary gland: 95.3846% (minimum 99%, Missing); rectum: 89.8551% (minimum 97%, Missing); retina: 68.1319% (minimum 99%, Missing); salivary gland: 89.8551% (minimum 97%, Missing); skeletal muscle: 87.3239% (minimum 99%, Missing); skin: 84.9315% (minimum 95%, Missing); small intestine: 93.9394% (minimum 99%, Missing); smooth muscle: 87.3239% (minimum 99%, Missing); spinal cord: 93.9394% (minimum 99%, Missing); spleen: 83.7838% (minimum 95%, Missing); stomach: 91.1765% (minimum 97%, Missing); thymus: 86.1111% (minimum 95%, Missing); thyroid gland: 78.4810% (minimum 95%, Missing); tongue: 91.1765% (minimum 97%, Missing); urinary bladder: 92.5373% (minimum 97%, Missing)",-0.16519,-0.108889,-0.308681,0,80,unavailable,2.9,1,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258405,ZNF578,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 68.1319% (minimum 75%, Missing)",0.13481,0.161111,-0.0686813,0,80,unavailable,2.9,1,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258405,ZNF578,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 68.1319% (minimum 75%, Missing)",0.13481,0.161111,-0.0686813,0,80,unavailable,2.9,1,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258405,ZNF578,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 68.1319% (minimum 75%, Missing)",0.13481,0.161111,-0.0686813,0,80,unavailable,2.9,1,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258405,ZNF578,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 68.1319% (minimum 75%, Baseline (adaptation disabled))",0.13481,0.161111,-0.0686813,0,80,unavailable,2.9,1,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258405,ZNF578,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0.2,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258436,RNASE12,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0.2,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258436,RNASE12,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0.2,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258436,RNASE12,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0.2,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258436,RNASE12,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
True,compatible,,True,True,True,,0.35,0.3,0.249706,0,4,partial,0.2,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258436,RNASE12,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased"
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000258597,SERPINA2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000258597,SERPINA2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000258597,SERPINA2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000258597,SERPINA2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000258597,SERPINA2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.7520% (minimum 99%, Missing)",0.0476359,0.03,-0.0024805,0,80,unavailable,1.6,0,0.3,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258713,C20orf141,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347636,0.3,0.23752,0,80,unavailable,1.6,0,0.3,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258713,C20orf141,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347636,0.3,0.23752,0,80,unavailable,1.6,0,0.3,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258713,C20orf141,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347636,0.3,0.23752,0,80,unavailable,1.6,0,0.3,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258713,C20orf141,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347636,0.3,0.23752,0,80,unavailable,1.6,0,0.3,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258713,C20orf141,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258992,TSPY1,admission_only,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258992,TSPY1,selectivity_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258992,TSPY1,grid_revised,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258992,TSPY1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000258992,TSPY1,current_fixed,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259060,ENSG00000259060,admission_only,True,False,True,True,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259060,ENSG00000259060,selectivity_revised,True,False,True,True,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259060,ENSG00000259060,grid_revised,True,False,True,True,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259060,ENSG00000259060,current_adaptive,True,False,True,True,10.1038/ncomms10499,Wang 2016
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259060,ENSG00000259060,current_fixed,True,False,True,True,10.1038/ncomms10499,Wang 2016
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.0392% (minimum 99%, Missing); cerebellum: 98.0392% (minimum 99%, Missing); retina: 98.0392% (minimum 99%, Missing); skeletal muscle: 92.5926% (minimum 99%, Missing)",0.05,0.03,-0.0640741,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259224,SLC35G6,admission_only,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023
True,compatible,,True,True,True,,0.35,0.3,0.175926,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259224,SLC35G6,selectivity_revised,True,False,True,False,10.1136/jitc-2023-007935,Carter 2023
True,compatible,,True,True,True,,0.35,0.3,0.175926,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259224,SLC35G6,grid_revised,True,False,True,False,10.1136/jitc-2023-007935,Carter 2023
True,compatible,,True,True,True,,0.35,0.3,0.175926,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259224,SLC35G6,current_adaptive,True,False,True,False,10.1136/jitc-2023-007935,Carter 2023
True,compatible,,True,True,True,,0.35,0.3,0.175926,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259224,SLC35G6,current_fixed,True,False,True,False,10.1136/jitc-2023-007935,Carter 2023
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259316,ENSG00000259316,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259316,ENSG00000259316,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259316,ENSG00000259316,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259316,ENSG00000259316,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259316,ENSG00000259316,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 33.3333% (minimum 99%, Missing); heart muscle: 50.0000% (minimum 99%, Missing)",0.05,0.03,-0.656667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259571,BLID,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 33.3333% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259571,BLID,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 33.3333% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259571,BLID,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 33.3333% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259571,BLID,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 33.3333% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 50.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259571,BLID,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 92.8571% (minimum 99%, Missing); lung: 92.8571% (minimum 99%, Missing)",0.00588235,0.0148485,-0.0614286,0,80,unavailable,1,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000260286,ARMH2,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.305882,0.284848,0.178571,0,80,unavailable,1,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000260286,ARMH2,selectivity_revised,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.305882,0.284848,0.178571,0,80,unavailable,1,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000260286,ARMH2,grid_revised,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.305882,0.284848,0.178571,0,80,unavailable,1,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000260286,ARMH2,current_adaptive,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
True,compatible,,True,True,True,,0.305882,0.284848,0.178571,0,80,unavailable,1,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000260286,ARMH2,current_fixed,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 96.9466% (minimum 97%, Supported); amygdala: 97.3180% (minimum 99%, Missing); basal ganglia: 96.5779% (minimum 99%, Missing); cerebellum: 92.3636% (minimum 97%, Supported); cerebral cortex: 95.8491% (minimum 97%, Supported); hippocampal formation: 95.8491% (minimum 99%, Missing); hypothalamus: 97.3180% (minimum 99%, Missing); kidney: 90.3915% (minimum 99%, Missing); liver: 95.4887% (minimum 97%, Supported); midbrain: 97.6923% (minimum 99%, Missing); pituitary gland: 96.5779% (minimum 99%, Missing); spinal cord: 97.3180% (minimum 99%, Missing)",0.05,0.010695,-0.0860854,0,2,partial,2.7,1.2,1.4,"kidney: 2.7 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260287,TBC1D3G,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.280695,0.153915,0,2,partial,2.7,1.2,1.4,"kidney: 2.7 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260287,TBC1D3G,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.280695,0.153915,0,2,partial,2.7,1.2,1.4,"kidney: 2.7 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260287,TBC1D3G,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.280695,0.153915,0,2,partial,2.7,1.2,1.4,"kidney: 2.7 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260287,TBC1D3G,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.297761,0.254887,0.153915,0,2,partial,2.7,1.2,1.4,"kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260287,TBC1D3G,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.3832% (minimum 97%, Supported); amygdala: 96.1951% (minimum 99%, Missing); basal ganglia: 96.6667% (minimum 99%, Missing); bone marrow: 96.7615% (minimum 97%, Supported); cerebral cortex: 96.0078% (minimum 97%, Supported); choroid plexus: 98.6000% (minimum 99%, Missing); duodenum: 98.6000% (minimum 99%, Missing); hippocampal formation: 96.9518% (minimum 99%, Missing); hypothalamus: 96.9518% (minimum 99%, Missing); liver: 93.5484% (minimum 97%, Supported); midbrain: 95.8212% (minimum 99%, Missing); pancreas: 96.9518% (minimum 97%, Supported); pituitary gland: 97.8175% (minimum 99%, Missing); skeletal muscle: 95.9144% (minimum 97%, Supported); small intestine: 98.5015% (minimum 99%, Missing); spinal cord: 96.9518% (minimum 99%, Missing)",0.0330508,0.000472441,-0.0345161,0,10,partial,6.8,3,2.4,"liver: 6.8 nTPM (vital, limit 3); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 3); cerebral cortex: 4.1 nTPM (vital, limit 3); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 3); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000260456,C16orf95,admission_only,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.333051,0.270472,0.208212,0,10,partial,6.8,3,2.4,"liver: 6.8 nTPM (vital, limit 3); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 3); cerebral cortex: 4.1 nTPM (vital, limit 3); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 3); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000260456,C16orf95,selectivity_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.333051,0.270472,0.208212,0,10,partial,6.8,3,2.4,"liver: 6.8 nTPM (vital, limit 3); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 3); cerebral cortex: 4.1 nTPM (vital, limit 3); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 3); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000260456,C16orf95,grid_revised,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.333051,0.270472,0.208212,0,10,partial,6.8,3,2.4,"liver: 6.8 nTPM (vital, limit 3); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 3); cerebral cortex: 4.1 nTPM (vital, limit 3); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 3); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000260456,C16orf95,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.326238,0.270472,0.185484,0,10,partial,6.8,3,2.4,"liver: 6.8 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000260456,C16orf95,current_fixed,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 90.0000% (minimum 99%, Missing); cerebral cortex: 90.0000% (minimum 99%, Missing); duodenum: 75.0000% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); lymph node: 90.0000% (minimum 97%, Missing); pancreas: 90.0000% (minimum 99%, Missing); salivary gland: 81.8182% (minimum 97%, Missing); skeletal muscle: 90.0000% (minimum 99%, Missing); skin: 90.0000% (minimum 95%, Missing); stomach: 90.0000% (minimum 97%, Missing); thymus: 90.0000% (minimum 95%, Missing)",-0.05,-0.151818,-0.24,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260596,DUX4,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.25,0.118182,0,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260596,DUX4,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.25,0.118182,0,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260596,DUX4,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.25,0.118182,0,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260596,DUX4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.25,0.118182,0,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260596,DUX4,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260734,TLE7,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260734,TLE7,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260734,TLE7,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260734,TLE7,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000260734,TLE7,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.0102558,0.0285748,0.00620853,0,80,unavailable,0.8,0.3,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261341,SMIM47,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.310256,0.298575,0.246209,0,80,unavailable,0.8,0.3,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261341,SMIM47,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.310256,0.298575,0.246209,0,80,unavailable,0.8,0.3,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261341,SMIM47,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.310256,0.298575,0.246209,0,80,unavailable,0.8,0.3,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261341,SMIM47,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.310256,0.298575,0.246209,0,80,unavailable,0.8,0.3,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261341,SMIM47,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 97.7273% (minimum 99%, Missing)",0.05,0.03,-0.0127273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261509,TP53TG3B,admission_only,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.227273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261509,TP53TG3B,selectivity_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.227273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261509,TP53TG3B,grid_revised,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.227273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261509,TP53TG3B,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.227273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261509,TP53TG3B,current_fixed,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.5401% (minimum 99%, Missing)",0.04631,0.03,-0.00459854,0,80,unavailable,0.4,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261649,GOLGA6L7,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.34631,0.3,0.235401,0,80,unavailable,0.4,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261649,GOLGA6L7,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.34631,0.3,0.235401,0,80,unavailable,0.4,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261649,GOLGA6L7,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.34631,0.3,0.235401,0,80,unavailable,0.4,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261649,GOLGA6L7,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.34631,0.3,0.235401,0,80,unavailable,0.4,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261649,GOLGA6L7,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 94.2857% (minimum 95%, Missing); bone marrow: 89.1892% (minimum 99%, Missing); cerebral cortex: 91.6667% (minimum 99%, Missing); duodenum: 91.6667% (minimum 99%, Missing); heart muscle: 94.2857% (minimum 99%, Missing); pancreas: 82.5000% (minimum 99%, Missing); retina: 94.2857% (minimum 99%, Missing); small intestine: 97.0588% (minimum 99%, Missing); stomach: 94.2857% (minimum 97%, Missing)",-0.00714286,-0.0271429,-0.165,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261739,GOLGA8S,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.292857,0.242857,0.075,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261739,GOLGA8S,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.292857,0.242857,0.075,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261739,GOLGA8S,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.292857,0.242857,0.075,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261739,GOLGA8S,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.292857,0.242857,0.075,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261739,GOLGA8S,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"bone marrow: 96.4286% (minimum 99%, Missing); cerebral cortex: 96.4286% (minimum 99%, Missing); retina: 20.4545% (minimum 99%, Missing)",0.0142857,0.03,-0.785455,0,80,unavailable,10.5,0,0.1,"retina: 10.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261873,SMIM36,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 20.4545% (minimum 75%, Missing)",0.314286,0.3,-0.545455,0,80,unavailable,10.5,0,0.1,"retina: 10.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261873,SMIM36,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 20.4545% (minimum 75%, Missing)",0.314286,0.3,-0.545455,0,80,unavailable,10.5,0,0.1,"retina: 10.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261873,SMIM36,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 20.4545% (minimum 75%, Missing)",0.314286,0.3,-0.545455,0,80,unavailable,10.5,0,0.1,"retina: 10.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261873,SMIM36,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 20.4545% (minimum 75%, Baseline (adaptation disabled))",0.314286,0.3,-0.545455,0,80,unavailable,10.5,0,0.1,"retina: 10.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000261873,SMIM36,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 72.2222% (minimum 99%, Missing); cerebral cortex: 92.8571% (minimum 99%, Missing); retina: 68.4211% (minimum 99%, Missing)",0.05,0.03,-0.305789,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261949,GFY,admission_only,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 72.2222% (minimum 75%, Missing); retina: 68.4211% (minimum 75%, Missing)",0.35,0.3,-0.0657895,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261949,GFY,selectivity_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 72.2222% (minimum 75%, Missing); retina: 68.4211% (minimum 75%, Missing)",0.35,0.3,-0.0657895,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261949,GFY,grid_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 72.2222% (minimum 75%, Missing); retina: 68.4211% (minimum 75%, Missing)",0.35,0.3,-0.0657895,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261949,GFY,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 72.2222% (minimum 75%, Baseline (adaptation disabled)); retina: 68.4211% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.0657895,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000261949,GFY,current_fixed,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 64.0288% (minimum 95%, Uncertain); adrenal gland: 63.5714% (minimum 99%, Uncertain); amygdala: 65.9259% (minimum 99%, Missing); basal ganglia: 52.5591% (minimum 99%, Missing); bone marrow: 27.9874% (minimum 99%, Missing); cerebellum: 68.2864% (minimum 99%, Uncertain); cerebral cortex: 60.4072% (minimum 99%, Uncertain); choroid plexus: 81.4024% (minimum 99%, Missing); colon: 57.4194% (minimum 97%, Missing); duodenum: 64.4928% (minimum 99%, Missing); esophagus: 71.5818% (minimum 97%, Uncertain); heart muscle: 70.2632% (minimum 99%, Uncertain); hippocampal formation: 56.4482% (minimum 99%, Missing); hypothalamus: 67.2544% (minimum 99%, Missing); kidney: 63.8756% (minimum 99%, Missing); liver: 75.6374% (minimum 99%, Uncertain); lung: 50.0000% (minimum 99%, Missing); lymph node: 52.9762% (minimum 97%, Missing); midbrain: 63.2701% (minimum 99%, Missing); pancreas: 71.7742% (minimum 99%, Missing); parathyroid gland: 85.8521% (minimum 97%, Uncertain); pituitary gland: 67.0854% (minimum 99%, Missing); rectum: 85.5769% (minimum 97%, Missing); retina: 95.0178% (minimum 99%, Missing); salivary gland: 67.2544% (minimum 97%, Uncertain); skeletal muscle: 81.1550% (minimum 99%, Missing); skin: 70.2632% (minimum 95%, Missing); small intestine: 46.9244% (minimum 99%, Missing); smooth muscle: 83.4375% (minimum 99%, Missing); spinal cord: 56.8085% (minimum 99%, Missing); spleen: 32.6007% (minimum 95%, Missing); stomach: 64.1827% (minimum 97%, Missing); thymus: 71.5818% (minimum 95%, Missing); thyroid gland: 65.6020% (minimum 95%, Uncertain); tongue: 94.3463% (minimum 97%, Missing); urinary bladder: 65.4412% (minimum 97%, Uncertain)",-0.623993,-0.440238,-0.710126,0,2,partial,68.7,23.7,55.2,"bone marrow: 68.7 nTPM (vital, limit 1); spleen: 55.2 nTPM (manageable, limit 5); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 2); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 2); cerebral cortex: 17.5 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); stomach: 14.9 nTPM (protected, limit 2); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 2); thyroid gland: 14 nTPM (manageable, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 2); cerebellum: 12.4 nTPM (vital, limit 1); skin: 11.3 nTPM (manageable, limit 5); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 2); thymus: 10.6 nTPM (manageable, limit 5); pancreas: 10.5 nTPM (vital, limit 1); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); parathyroid gland: 4.4 nTPM (protected, limit 2); retina: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262246,CORO7,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 64.0288% (minimum 65%, Uncertain); adrenal gland: 63.5714% (minimum 75%, Uncertain); amygdala: 65.9259% (minimum 75%, Missing); basal ganglia: 52.5591% (minimum 75%, Missing); bone marrow: 27.9874% (minimum 75%, Missing); cerebellum: 68.2864% (minimum 75%, Uncertain); cerebral cortex: 60.4072% (minimum 75%, Uncertain); colon: 57.4194% (minimum 70%, Missing); duodenum: 64.4928% (minimum 75%, Missing); heart muscle: 70.2632% (minimum 75%, Uncertain); hippocampal formation: 56.4482% (minimum 75%, Missing); hypothalamus: 67.2544% (minimum 75%, Missing); kidney: 63.8756% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 52.9762% (minimum 70%, Missing); midbrain: 63.2701% (minimum 75%, Missing); pancreas: 71.7742% (minimum 75%, Missing); pituitary gland: 67.0854% (minimum 75%, Missing); salivary gland: 67.2544% (minimum 70%, Uncertain); small intestine: 46.9244% (minimum 75%, Missing); spinal cord: 56.8085% (minimum 75%, Missing); spleen: 32.6007% (minimum 65%, Missing); stomach: 64.1827% (minimum 70%, Missing); urinary bladder: 65.4412% (minimum 70%, Uncertain)",-0.323993,-0.170238,-0.470126,0,2,partial,68.7,23.7,55.2,"bone marrow: 68.7 nTPM (vital, limit 1); spleen: 55.2 nTPM (manageable, limit 5); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 2); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 2); cerebral cortex: 17.5 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); stomach: 14.9 nTPM (protected, limit 2); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 2); thyroid gland: 14 nTPM (manageable, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 2); cerebellum: 12.4 nTPM (vital, limit 1); skin: 11.3 nTPM (manageable, limit 5); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 2); thymus: 10.6 nTPM (manageable, limit 5); pancreas: 10.5 nTPM (vital, limit 1); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); parathyroid gland: 4.4 nTPM (protected, limit 2); retina: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262246,CORO7,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 64.0288% (minimum 65%, Uncertain); adrenal gland: 63.5714% (minimum 75%, Uncertain); amygdala: 65.9259% (minimum 75%, Missing); basal ganglia: 52.5591% (minimum 75%, Missing); bone marrow: 27.9874% (minimum 75%, Missing); cerebellum: 68.2864% (minimum 75%, Uncertain); cerebral cortex: 60.4072% (minimum 75%, Uncertain); colon: 57.4194% (minimum 70%, Missing); duodenum: 64.4928% (minimum 75%, Missing); heart muscle: 70.2632% (minimum 75%, Uncertain); hippocampal formation: 56.4482% (minimum 75%, Missing); hypothalamus: 67.2544% (minimum 75%, Missing); kidney: 63.8756% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 52.9762% (minimum 70%, Missing); midbrain: 63.2701% (minimum 75%, Missing); pancreas: 71.7742% (minimum 75%, Missing); pituitary gland: 67.0854% (minimum 75%, Missing); salivary gland: 67.2544% (minimum 70%, Uncertain); small intestine: 46.9244% (minimum 75%, Missing); spinal cord: 56.8085% (minimum 75%, Missing); spleen: 32.6007% (minimum 65%, Missing); stomach: 64.1827% (minimum 70%, Missing); urinary bladder: 65.4412% (minimum 70%, Uncertain)",-0.323993,-0.170238,-0.470126,0,2,partial,68.7,23.7,55.2,"bone marrow: 68.7 nTPM (vital, limit 1); spleen: 55.2 nTPM (manageable, limit 5); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 3); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 3); cerebral cortex: 17.5 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); stomach: 14.9 nTPM (protected, limit 3); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 3); thyroid gland: 14 nTPM (manageable, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 3); cerebellum: 12.4 nTPM (vital, limit 1); skin: 11.3 nTPM (manageable, limit 5); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 3); thymus: 10.6 nTPM (manageable, limit 5); pancreas: 10.5 nTPM (vital, limit 1); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); parathyroid gland: 4.4 nTPM (protected, limit 3); retina: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262246,CORO7,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 64.0288% (minimum 65%, Uncertain); adrenal gland: 63.5714% (minimum 75%, Uncertain); amygdala: 65.9259% (minimum 75%, Missing); basal ganglia: 52.5591% (minimum 75%, Missing); bone marrow: 27.9874% (minimum 75%, Missing); cerebellum: 68.2864% (minimum 75%, Uncertain); cerebral cortex: 60.4072% (minimum 75%, Uncertain); colon: 57.4194% (minimum 70%, Missing); duodenum: 64.4928% (minimum 75%, Missing); heart muscle: 70.2632% (minimum 75%, Uncertain); hippocampal formation: 56.4482% (minimum 75%, Missing); hypothalamus: 67.2544% (minimum 75%, Missing); kidney: 63.8756% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 52.9762% (minimum 70%, Missing); midbrain: 63.2701% (minimum 75%, Missing); pancreas: 71.7742% (minimum 75%, Missing); pituitary gland: 67.0854% (minimum 75%, Missing); salivary gland: 67.2544% (minimum 70%, Uncertain); small intestine: 46.9244% (minimum 75%, Missing); spinal cord: 56.8085% (minimum 75%, Missing); spleen: 32.6007% (minimum 65%, Missing); stomach: 64.1827% (minimum 70%, Missing); urinary bladder: 65.4412% (minimum 70%, Uncertain)",-0.323993,-0.170238,-0.470126,0,2,partial,68.7,23.7,55.2,"bone marrow: 68.7 nTPM (vital, limit 1); spleen: 55.2 nTPM (manageable, limit 5); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 3); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 3); cerebral cortex: 17.5 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); stomach: 14.9 nTPM (protected, limit 3); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 3); thyroid gland: 14 nTPM (manageable, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 3); cerebellum: 12.4 nTPM (vital, limit 1); skin: 11.3 nTPM (manageable, limit 5); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 3); thymus: 10.6 nTPM (manageable, limit 5); pancreas: 10.5 nTPM (vital, limit 1); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); parathyroid gland: 4.4 nTPM (protected, limit 3); retina: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262246,CORO7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 64.0288% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 63.5714% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.9259% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 52.5591% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 27.9874% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 68.2864% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 60.4072% (minimum 75%, Baseline (adaptation disabled)); colon: 57.4194% (minimum 70%, Baseline (adaptation disabled)); duodenum: 64.4928% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 70.2632% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 56.4482% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.2544% (minimum 75%, Baseline (adaptation disabled)); kidney: 63.8756% (minimum 75%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 52.9762% (minimum 70%, Baseline (adaptation disabled)); midbrain: 63.2701% (minimum 75%, Baseline (adaptation disabled)); pancreas: 71.7742% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 67.0854% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 67.2544% (minimum 70%, Baseline (adaptation disabled)); small intestine: 46.9244% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 56.8085% (minimum 75%, Baseline (adaptation disabled)); spleen: 32.6007% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.1827% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.4412% (minimum 70%, Baseline (adaptation disabled))",-0.323993,-0.170238,-0.470126,0,2,partial,68.7,23.7,55.2,"bone marrow: 68.7 nTPM (vital, limit 1); spleen: 55.2 nTPM (manageable, limit 5); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 3); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 3); cerebral cortex: 17.5 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); stomach: 14.9 nTPM (protected, limit 3); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 3); thyroid gland: 14 nTPM (manageable, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 3); cerebellum: 12.4 nTPM (vital, limit 1); skin: 11.3 nTPM (manageable, limit 5); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 3); thymus: 10.6 nTPM (manageable, limit 5); pancreas: 10.5 nTPM (vital, limit 1); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); parathyroid gland: 4.4 nTPM (protected, limit 3); retina: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262246,CORO7,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.8750% (minimum 95%, Missing); adrenal gland: 53.5714% (minimum 99%, Missing); amygdala: 50.0000% (minimum 99%, Missing); basal ganglia: 40.5405% (minimum 99%, Missing); cerebellum: 44.1176% (minimum 99%, Missing); cerebral cortex: 31.2500% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 65.2174% (minimum 97%, Missing); duodenum: 88.2353% (minimum 99%, Missing); esophagus: 78.9474% (minimum 97%, Missing); heart muscle: 51.7241% (minimum 99%, Missing); hippocampal formation: 55.5556% (minimum 99%, Missing); hypothalamus: 55.5556% (minimum 99%, Missing); kidney: 78.9474% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 60.0000% (minimum 99%, Missing); lymph node: 93.7500% (minimum 97%, Missing); midbrain: 57.6923% (minimum 99%, Missing); pancreas: 42.8571% (minimum 99%, Missing); parathyroid gland: 40.5405% (minimum 97%, Missing); pituitary gland: 60.0000% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 68.1818% (minimum 97%, Missing); skeletal muscle: 68.1818% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 83.3333% (minimum 99%, Missing); smooth muscle: 51.7241% (minimum 99%, Missing); spinal cord: 53.5714% (minimum 99%, Missing); spleen: 88.2353% (minimum 95%, Missing); stomach: 78.9474% (minimum 97%, Missing); thymus: 88.2353% (minimum 95%, Missing); thyroid gland: 71.4286% (minimum 95%, Missing); tongue: 62.5000% (minimum 97%, Missing); urinary bladder: 68.1818% (minimum 97%, Missing)",-0.48125,-0.564595,-0.6775,0,80,unavailable,3.3,2.2,1.7,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262576,PCDHGA4,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.8750% (minimum 65%, Missing); adrenal gland: 53.5714% (minimum 75%, Missing); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 40.5405% (minimum 75%, Missing); cerebellum: 44.1176% (minimum 75%, Missing); cerebral cortex: 31.2500% (minimum 75%, Missing); colon: 65.2174% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); midbrain: 57.6923% (minimum 75%, Missing); pancreas: 42.8571% (minimum 75%, Missing); parathyroid gland: 40.5405% (minimum 70%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 68.1818% (minimum 75%, Missing); smooth muscle: 51.7241% (minimum 75%, Missing); spinal cord: 53.5714% (minimum 75%, Missing); tongue: 62.5000% (minimum 70%, Missing); urinary bladder: 68.1818% (minimum 70%, Missing)",-0.18125,-0.294595,-0.4375,0,80,unavailable,3.3,2.2,1.7,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262576,PCDHGA4,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.8750% (minimum 65%, Missing); adrenal gland: 53.5714% (minimum 75%, Missing); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 40.5405% (minimum 75%, Missing); cerebellum: 44.1176% (minimum 75%, Missing); cerebral cortex: 31.2500% (minimum 75%, Missing); colon: 65.2174% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); midbrain: 57.6923% (minimum 75%, Missing); pancreas: 42.8571% (minimum 75%, Missing); parathyroid gland: 40.5405% (minimum 70%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 68.1818% (minimum 75%, Missing); smooth muscle: 51.7241% (minimum 75%, Missing); spinal cord: 53.5714% (minimum 75%, Missing); tongue: 62.5000% (minimum 70%, Missing); urinary bladder: 68.1818% (minimum 70%, Missing)",-0.18125,-0.294595,-0.4375,0,80,unavailable,3.3,2.2,1.7,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262576,PCDHGA4,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.8750% (minimum 65%, Missing); adrenal gland: 53.5714% (minimum 75%, Missing); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 40.5405% (minimum 75%, Missing); cerebellum: 44.1176% (minimum 75%, Missing); cerebral cortex: 31.2500% (minimum 75%, Missing); colon: 65.2174% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); midbrain: 57.6923% (minimum 75%, Missing); pancreas: 42.8571% (minimum 75%, Missing); parathyroid gland: 40.5405% (minimum 70%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 68.1818% (minimum 75%, Missing); smooth muscle: 51.7241% (minimum 75%, Missing); spinal cord: 53.5714% (minimum 75%, Missing); tongue: 62.5000% (minimum 70%, Missing); urinary bladder: 68.1818% (minimum 70%, Missing)",-0.18125,-0.294595,-0.4375,0,80,unavailable,3.3,2.2,1.7,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262576,PCDHGA4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.8750% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 53.5714% (minimum 75%, Baseline (adaptation disabled)); amygdala: 50.0000% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 40.5405% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 44.1176% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 31.2500% (minimum 75%, Baseline (adaptation disabled)); colon: 65.2174% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 51.7241% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 55.5556% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 55.5556% (minimum 75%, Baseline (adaptation disabled)); lung: 60.0000% (minimum 75%, Baseline (adaptation disabled)); midbrain: 57.6923% (minimum 75%, Baseline (adaptation disabled)); pancreas: 42.8571% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 40.5405% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 68.1818% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 68.1818% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 51.7241% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 53.5714% (minimum 75%, Baseline (adaptation disabled)); tongue: 62.5000% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 68.1818% (minimum 70%, Baseline (adaptation disabled))",-0.18125,-0.294595,-0.4375,0,80,unavailable,3.3,2.2,1.7,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262576,PCDHGA4,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"bone marrow: 97.2727% (minimum 99%, Uncertain)",0.0316514,0.0207407,-0.0172727,0,1,partial,0.6,0.2,0.4,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262874,C19orf84,admission_only,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.331651,0.290741,0.222727,0,1,partial,0.6,0.2,0.4,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262874,C19orf84,selectivity_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.331651,0.290741,0.222727,0,1,partial,0.6,0.2,0.4,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262874,C19orf84,grid_revised,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.331651,0.290741,0.222727,0,1,partial,0.6,0.2,0.4,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262874,C19orf84,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted,True,True,True,,0.331651,0.290741,0.222727,0,1,partial,0.6,0.2,0.4,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000262874,C19orf84,current_fixed,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000266826,IGBP1C,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000266826,IGBP1C,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000266826,IGBP1C,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000266826,IGBP1C,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000266826,IGBP1C,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 60.0000% (minimum 98%, Approved); pancreas: 10.3448% (minimum 98%, Approved); pituitary gland: 6.8182% (minimum 99%, Missing)",0.05,0.03,-0.921818,0,2,partial,4.1,0,0,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 2)",pituitary gland / cells in anterior : High (Approved),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267631,CGB1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 60.0000% (minimum 70%, Approved); pancreas: 10.3448% (minimum 70%, Approved); pituitary gland: 6.8182% (minimum 75%, Missing)",0.35,0.3,-0.681818,0,2,partial,4.1,0,0,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 2)",pituitary gland / cells in anterior : High (Approved),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267631,CGB1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 60.0000% (minimum 70%, Approved); pancreas: 10.3448% (minimum 70%, Approved); pituitary gland: 6.8182% (minimum 75%, Missing)",0.35,0.3,-0.681818,0,2,partial,4.1,0,0,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 2)",pituitary gland / cells in anterior : High (Approved),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267631,CGB1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 60.0000% (minimum 70%, Approved); pancreas: 10.3448% (minimum 70%, Approved); pituitary gland: 6.8182% (minimum 75%, Missing)",0.35,0.3,-0.681818,0,2,partial,4.1,0,0,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 2)",pituitary gland / cells in anterior : High (Approved),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267631,CGB1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 60.0000% (minimum 75%, Baseline (adaptation disabled)); pancreas: 10.3448% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 6.8182% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.681818,0,2,partial,4.1,0,0,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Approved),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267631,CGB1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.8831% (minimum 60%, Enhanced); adrenal gland: 38.2374% (minimum 99%, Missing); amygdala: 39.5331% (minimum 99%, Missing); basal ganglia: 37.9061% (minimum 99%, Missing); bone marrow: 60.9049% (minimum 99%, Missing); cerebellum: 58.7248% (minimum 99%, Missing); cerebral cortex: 42.3387% (minimum 99%, Missing); choroid plexus: 23.0871% (minimum 99%, Missing); colon: 53.7359% (minimum 97%, Missing); duodenum: 69.1700% (minimum 99%, Missing); esophagus: 48.3871% (minimum 97%, Missing); heart muscle: 24.3959% (minimum 99%, Missing); hippocampal formation: 46.1741% (minimum 99%, Missing); hypothalamus: 45.6919% (minimum 99%, Missing); kidney: 37.9335% (minimum 99%, Missing); liver: 39.2084% (minimum 99%, Missing); lung: 63.5593% (minimum 99%, Missing); lymph node: 64.5756% (minimum 97%, Missing); midbrain: 40.3536% (minimum 99%, Missing); pancreas: 59.3891% (minimum 99%, Missing); parathyroid gland: 34.5168% (minimum 97%, Missing); pituitary gland: 38.4334% (minimum 99%, Missing); rectum: 61.8375% (minimum 97%, Missing); retina: 62.7240% (minimum 99%, Missing); salivary gland: 55.4382% (minimum 97%, Missing); skeletal muscle: 18.1347% (minimum 99%, Missing); skin: 63.7910% (minimum 95%, Missing); small intestine: 61.4035% (minimum 99%, Missing); smooth muscle: 70.5645% (minimum 99%, Missing); spinal cord: 54.4606% (minimum 99%, Missing); spleen: 56.1497% (minimum 95%, Missing); stomach: 49.6689% (minimum 97%, Missing); thymus: 56.9414% (minimum 95%, Missing); thyroid gland: 56.6955% (minimum 95%, Missing); tongue: 18.4017% (minimum 97%, Missing); urinary bladder: 60.4143% (minimum 97%, Missing)",-0.388503,-0.785983,-0.808653,0,6,partial,237,232.8,41,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 2); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 2); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 2); stomach: 53.2 nTPM (protected, limit 2); colon: 45.2 nTPM (protected, limit 2); spinal cord: 43.9 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 2); spleen: 41 nTPM (manageable, limit 5); thyroid gland: 40.1 nTPM (manageable, limit 5); thymus: 39.7 nTPM (manageable, limit 5); adipose tissue: 38.2 nTPM (manageable, limit 30); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 2); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 2); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); lymph node: 28.8 nTPM (protected, limit 2); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 1 / vascular mural cells: Low (Enhanced); skin 2 / arrector pili muscle cells: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); skin 2 / vascular mural cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / arrector pili muscle cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / sebaceous glands; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267855,NDUFA7,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 38.2374% (minimum 75%, Missing); amygdala: 39.5331% (minimum 75%, Missing); basal ganglia: 37.9061% (minimum 75%, Missing); bone marrow: 60.9049% (minimum 75%, Missing); cerebellum: 58.7248% (minimum 75%, Missing); cerebral cortex: 42.3387% (minimum 75%, Missing); choroid plexus: 23.0871% (minimum 75%, Missing); colon: 53.7359% (minimum 70%, Missing); duodenum: 69.1700% (minimum 75%, Missing); esophagus: 48.3871% (minimum 70%, Missing); heart muscle: 24.3959% (minimum 75%, Missing); hippocampal formation: 46.1741% (minimum 75%, Missing); hypothalamus: 45.6919% (minimum 75%, Missing); kidney: 37.9335% (minimum 75%, Missing); liver: 39.2084% (minimum 75%, Missing); lung: 63.5593% (minimum 75%, Missing); lymph node: 64.5756% (minimum 70%, Missing); midbrain: 40.3536% (minimum 75%, Missing); pancreas: 59.3891% (minimum 75%, Missing); parathyroid gland: 34.5168% (minimum 70%, Missing); pituitary gland: 38.4334% (minimum 75%, Missing); rectum: 61.8375% (minimum 70%, Missing); retina: 62.7240% (minimum 75%, Missing); salivary gland: 55.4382% (minimum 70%, Missing); skeletal muscle: 18.1347% (minimum 75%, Missing); skin: 63.7910% (minimum 65%, Missing); small intestine: 61.4035% (minimum 75%, Missing); smooth muscle: 70.5645% (minimum 75%, Missing); spinal cord: 54.4606% (minimum 75%, Missing); spleen: 56.1497% (minimum 65%, Missing); stomach: 49.6689% (minimum 70%, Missing); thymus: 56.9414% (minimum 65%, Missing); thyroid gland: 56.6955% (minimum 65%, Missing); tongue: 18.4017% (minimum 70%, Missing); urinary bladder: 60.4143% (minimum 70%, Missing)",-0.0885027,-0.515983,-0.568653,0,6,partial,237,232.8,41,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 2); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 2); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 2); stomach: 53.2 nTPM (protected, limit 2); colon: 45.2 nTPM (protected, limit 2); spinal cord: 43.9 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 2); spleen: 41 nTPM (manageable, limit 5); thyroid gland: 40.1 nTPM (manageable, limit 5); thymus: 39.7 nTPM (manageable, limit 5); adipose tissue: 38.2 nTPM (manageable, limit 30); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 2); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 2); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); lymph node: 28.8 nTPM (protected, limit 2); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 1 / vascular mural cells: Low (Enhanced); skin 2 / arrector pili muscle cells: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); skin 2 / vascular mural cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / arrector pili muscle cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / sebaceous glands; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267855,NDUFA7,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 38.2374% (minimum 75%, Missing); amygdala: 39.5331% (minimum 75%, Missing); basal ganglia: 37.9061% (minimum 75%, Missing); bone marrow: 60.9049% (minimum 75%, Missing); cerebellum: 58.7248% (minimum 75%, Missing); cerebral cortex: 42.3387% (minimum 75%, Missing); choroid plexus: 23.0871% (minimum 75%, Missing); colon: 53.7359% (minimum 70%, Missing); duodenum: 69.1700% (minimum 75%, Missing); esophagus: 48.3871% (minimum 70%, Missing); heart muscle: 24.3959% (minimum 75%, Missing); hippocampal formation: 46.1741% (minimum 75%, Missing); hypothalamus: 45.6919% (minimum 75%, Missing); kidney: 37.9335% (minimum 75%, Missing); liver: 39.2084% (minimum 75%, Missing); lung: 63.5593% (minimum 75%, Missing); lymph node: 64.5756% (minimum 70%, Missing); midbrain: 40.3536% (minimum 75%, Missing); pancreas: 59.3891% (minimum 75%, Missing); parathyroid gland: 34.5168% (minimum 70%, Missing); pituitary gland: 38.4334% (minimum 75%, Missing); rectum: 61.8375% (minimum 70%, Missing); retina: 62.7240% (minimum 75%, Missing); salivary gland: 55.4382% (minimum 70%, Missing); skeletal muscle: 18.1347% (minimum 75%, Missing); skin: 63.7910% (minimum 65%, Missing); small intestine: 61.4035% (minimum 75%, Missing); smooth muscle: 70.5645% (minimum 75%, Missing); spinal cord: 54.4606% (minimum 75%, Missing); spleen: 56.1497% (minimum 65%, Missing); stomach: 49.6689% (minimum 70%, Missing); thymus: 56.9414% (minimum 65%, Missing); thyroid gland: 56.6955% (minimum 65%, Missing); tongue: 18.4017% (minimum 70%, Missing); urinary bladder: 60.4143% (minimum 70%, Missing)",-0.0885027,-0.515983,-0.568653,0,6,partial,237,232.8,41,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 3); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 3); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 3); stomach: 53.2 nTPM (protected, limit 3); colon: 45.2 nTPM (protected, limit 3); spinal cord: 43.9 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 3); spleen: 41 nTPM (manageable, limit 5); thyroid gland: 40.1 nTPM (manageable, limit 5); thymus: 39.7 nTPM (manageable, limit 5); adipose tissue: 38.2 nTPM (manageable, limit 30); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 3); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 3); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); lymph node: 28.8 nTPM (protected, limit 3); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 1 / vascular mural cells: Low (Enhanced); skin 2 / arrector pili muscle cells: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); skin 2 / vascular mural cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / arrector pili muscle cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / sebaceous glands; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267855,NDUFA7,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 38.2374% (minimum 75%, Missing); amygdala: 39.5331% (minimum 75%, Missing); basal ganglia: 37.9061% (minimum 75%, Missing); bone marrow: 60.9049% (minimum 75%, Missing); cerebellum: 58.7248% (minimum 75%, Missing); cerebral cortex: 42.3387% (minimum 75%, Missing); choroid plexus: 23.0871% (minimum 75%, Missing); colon: 53.7359% (minimum 70%, Missing); duodenum: 69.1700% (minimum 75%, Missing); esophagus: 48.3871% (minimum 70%, Missing); heart muscle: 24.3959% (minimum 75%, Missing); hippocampal formation: 46.1741% (minimum 75%, Missing); hypothalamus: 45.6919% (minimum 75%, Missing); kidney: 37.9335% (minimum 75%, Missing); liver: 39.2084% (minimum 75%, Missing); lung: 63.5593% (minimum 75%, Missing); lymph node: 64.5756% (minimum 70%, Missing); midbrain: 40.3536% (minimum 75%, Missing); pancreas: 59.3891% (minimum 75%, Missing); parathyroid gland: 34.5168% (minimum 70%, Missing); pituitary gland: 38.4334% (minimum 75%, Missing); rectum: 61.8375% (minimum 70%, Missing); retina: 62.7240% (minimum 75%, Missing); salivary gland: 55.4382% (minimum 70%, Missing); skeletal muscle: 18.1347% (minimum 75%, Missing); skin: 63.7910% (minimum 65%, Missing); small intestine: 61.4035% (minimum 75%, Missing); smooth muscle: 70.5645% (minimum 75%, Missing); spinal cord: 54.4606% (minimum 75%, Missing); spleen: 56.1497% (minimum 65%, Missing); stomach: 49.6689% (minimum 70%, Missing); thymus: 56.9414% (minimum 65%, Missing); thyroid gland: 56.6955% (minimum 65%, Missing); tongue: 18.4017% (minimum 70%, Missing); urinary bladder: 60.4143% (minimum 70%, Missing)",-0.0885027,-0.515983,-0.568653,0,6,partial,237,232.8,41,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 3); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 3); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 3); stomach: 53.2 nTPM (protected, limit 3); colon: 45.2 nTPM (protected, limit 3); spinal cord: 43.9 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 3); spleen: 41 nTPM (manageable, limit 5); thyroid gland: 40.1 nTPM (manageable, limit 5); thymus: 39.7 nTPM (manageable, limit 5); adipose tissue: 38.2 nTPM (manageable, limit 30); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 3); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 3); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); lymph node: 28.8 nTPM (protected, limit 3); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 1 / vascular mural cells: Low (Enhanced); skin 2 / arrector pili muscle cells: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); skin 2 / vascular mural cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / arrector pili muscle cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / sebaceous glands; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267855,NDUFA7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.8831% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 38.2374% (minimum 75%, Baseline (adaptation disabled)); amygdala: 39.5331% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 37.9061% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 60.9049% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 58.7248% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 42.3387% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 23.0871% (minimum 75%, Baseline (adaptation disabled)); colon: 53.7359% (minimum 70%, Baseline (adaptation disabled)); duodenum: 69.1700% (minimum 75%, Baseline (adaptation disabled)); esophagus: 48.3871% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 24.3959% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 46.1741% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 45.6919% (minimum 75%, Baseline (adaptation disabled)); kidney: 37.9335% (minimum 75%, Baseline (adaptation disabled)); liver: 39.2084% (minimum 75%, Baseline (adaptation disabled)); lung: 63.5593% (minimum 75%, Baseline (adaptation disabled)); lymph node: 64.5756% (minimum 70%, Baseline (adaptation disabled)); midbrain: 40.3536% (minimum 75%, Baseline (adaptation disabled)); pancreas: 59.3891% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 34.5168% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 38.4334% (minimum 75%, Baseline (adaptation disabled)); rectum: 61.8375% (minimum 70%, Baseline (adaptation disabled)); retina: 62.7240% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 55.4382% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 18.1347% (minimum 75%, Baseline (adaptation disabled)); skin: 63.7910% (minimum 65%, Baseline (adaptation disabled)); small intestine: 61.4035% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 70.5645% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 54.4606% (minimum 75%, Baseline (adaptation disabled)); spleen: 56.1497% (minimum 65%, Baseline (adaptation disabled)); stomach: 49.6689% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.9414% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 56.6955% (minimum 65%, Baseline (adaptation disabled)); tongue: 18.4017% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 60.4143% (minimum 70%, Baseline (adaptation disabled))",-0.0885027,-0.515983,-0.568653,0,6,partial,237,232.8,41,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 3); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 3); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 3); stomach: 53.2 nTPM (protected, limit 3); colon: 45.2 nTPM (protected, limit 3); spinal cord: 43.9 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 3); spleen: 41 nTPM (manageable, limit 5); thyroid gland: 40.1 nTPM (manageable, limit 5); thymus: 39.7 nTPM (manageable, limit 5); adipose tissue: 38.2 nTPM (manageable, limit 5); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 3); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 3); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); lymph node: 28.8 nTPM (protected, limit 3); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 1 / vascular mural cells: Low (Enhanced); skin 2 / arrector pili muscle cells: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); skin 2 / vascular mural cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / arrector pili muscle cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / sebaceous glands; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267855,NDUFA7,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.9796% (minimum 99%, Missing)",0.029798,0.0197959,-0.000204082,0,80,unavailable,0.1,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267978,MAGEA9B,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.329798,0.289796,0.239796,0,80,unavailable,0.1,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267978,MAGEA9B,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.329798,0.289796,0.239796,0,80,unavailable,0.1,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267978,MAGEA9B,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.329798,0.289796,0.239796,0,80,unavailable,0.1,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267978,MAGEA9B,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.329798,0.289796,0.239796,0,80,unavailable,0.1,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000267978,MAGEA9B,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 93.9394% (minimum 99%, Missing); heart muscle: 96.8750% (minimum 97%, Supported)",0.05,0.03,-0.0506061,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268009,SSX4,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.189394,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268009,SSX4,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.189394,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268009,SSX4,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.189394,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268009,SSX4,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.26875,0.189394,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268009,SSX4,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); bone marrow: 40.0000% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); lung: 50.0000% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); spleen: 66.6667% (minimum 95%, Missing)",-0.283333,-0.47,-0.59,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268223,ARL14EPL,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 40.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing)",0.0166667,-0.2,-0.35,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268223,ARL14EPL,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 40.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing)",0.0166667,-0.2,-0.35,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268223,ARL14EPL,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 40.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing)",0.0166667,-0.2,-0.35,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268223,ARL14EPL,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 40.0000% (minimum 75%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 75%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled))",0.0166667,-0.2,-0.35,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268223,ARL14EPL,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.0039759,0,2,partial,0.1,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268447,SSX2B,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.243976,0,2,partial,0.1,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268447,SSX2B,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.243976,0,2,partial,0.1,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268447,SSX2B,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.243976,0,2,partial,0.1,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268447,SSX2B,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.332143,0.3,0.243976,0,2,partial,0.1,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268447,SSX2B,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 94.1176% (minimum 95%, Missing); bone marrow: 66.6667% (minimum 99%, Missing); cerebral cortex: 94.1176% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 94.1176% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); esophagus: 94.1176% (minimum 97%, Missing); heart muscle: 94.1176% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 88.8889% (minimum 99%, Missing); lung: 88.8889% (minimum 99%, Missing); lymph node: 84.2105% (minimum 97%, Missing); rectum: 94.1176% (minimum 97%, Missing); retina: 76.1905% (minimum 99%, Missing); salivary gland: 94.1176% (minimum 97%, Missing); skeletal muscle: 80.0000% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 94.1176% (minimum 99%, Missing); smooth muscle: 94.1176% (minimum 99%, Missing); spleen: 84.2105% (minimum 95%, Missing); stomach: 88.8889% (minimum 97%, Missing); thymus: 88.8889% (minimum 95%, Missing); thyroid gland: 94.1176% (minimum 95%, Missing); urinary bladder: 94.1176% (minimum 97%, Missing)",-0.15,-0.127895,-0.323333,9,80,unavailable,0.8,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268480,NFILZ,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.142105,-0.0833333,9,80,unavailable,0.8,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268480,NFILZ,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.142105,-0.0833333,9,80,unavailable,0.8,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268480,NFILZ,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.142105,-0.0833333,9,80,unavailable,0.8,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268480,NFILZ,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Baseline (adaptation disabled))",0.15,0.142105,-0.0833333,9,80,unavailable,0.8,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268480,NFILZ,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268606,MAGEA2,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268606,MAGEA2,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268606,MAGEA2,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268606,MAGEA2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268606,MAGEA2,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268629,TEX13A,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268629,TEX13A,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268629,TEX13A,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268629,TEX13A,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268629,TEX13A,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268651,CTAG1A,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268651,CTAG1A,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268651,CTAG1A,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268651,CTAG1A,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.337805,0.3,0.25,0,4,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268651,CTAG1A,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna,True,True,True,"bone marrow: 97.0588% (minimum 99%, Missing); pancreas: 97.0588% (minimum 99%, Missing); parathyroid gland: 94.2857% (minimum 97%, Missing)",0.05,-0.0271429,-0.0194118,9,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268696,ZNF723,admission_only,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.242857,0.220588,9,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268696,ZNF723,selectivity_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.242857,0.220588,9,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268696,ZNF723,grid_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.242857,0.220588,9,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268696,ZNF723,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.242857,0.220588,9,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268696,ZNF723,current_fixed,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.9091% (minimum 99%, Missing); basal ganglia: 87.5912% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 97%, Supported); cerebral cortex: 88.8889% (minimum 97%, Supported); choroid plexus: 88.2353% (minimum 99%, Missing); duodenum: 96.0000% (minimum 97%, Supported); heart muscle: 90.9091% (minimum 97%, Supported); hippocampal formation: 88.2353% (minimum 99%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); kidney: 96.0000% (minimum 97%, Supported); liver: 96.0000% (minimum 97%, Supported); lung: 96.0000% (minimum 97%, Supported); midbrain: 92.3077% (minimum 99%, Missing); pancreas: 96.7742% (minimum 97%, Supported); pituitary gland: 96.7742% (minimum 99%, Missing); retina: 92.3077% (minimum 99%, Missing); skeletal muscle: 94.4882% (minimum 97%, Supported); smooth muscle: 94.4882% (minimum 97%, Supported); spinal cord: 95.2381% (minimum 99%, Missing); tongue: 85.7143% (minimum 97%, Missing)",0.01,-0.112857,-0.114088,0,3,partial,1.7,2,1.1,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268738,HSFX2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.31,0.157143,0.125912,0,3,partial,1.7,2,1.1,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268738,HSFX2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.31,0.157143,0.125912,0,3,partial,1.7,2,1.1,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268738,HSFX2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.31,0.157143,0.125912,0,3,partial,1.7,2,1.1,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268738,HSFX2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.266031,0.157143,0.125912,0,3,partial,1.7,2,1.1,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268738,HSFX2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 90.9091% (minimum 99%, Missing); hippocampal formation: 90.9091% (minimum 99%, Missing); hypothalamus: 90.9091% (minimum 99%, Missing); kidney: 90.9091% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 90.9091% (minimum 99%, Missing); skin: 58.8235% (minimum 95%, Missing); spinal cord: 90.9091% (minimum 99%, Missing); spleen: 62.5000% (minimum 95%, Missing); urinary bladder: 90.9091% (minimum 97%, Missing)",-0.361765,-0.47,-0.0809091,0,80,unavailable,0.1,1,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268902,CSAG2,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 50.0000% (minimum 70%, Missing); skin: 58.8235% (minimum 65%, Missing); spleen: 62.5000% (minimum 65%, Missing)",-0.0617647,-0.2,0.159091,0,80,unavailable,0.1,1,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268902,CSAG2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 50.0000% (minimum 70%, Missing); skin: 58.8235% (minimum 65%, Missing); spleen: 62.5000% (minimum 65%, Missing)",-0.0617647,-0.2,0.159091,0,80,unavailable,0.1,1,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268902,CSAG2,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 50.0000% (minimum 70%, Missing); skin: 58.8235% (minimum 65%, Missing); spleen: 62.5000% (minimum 65%, Missing)",-0.0617647,-0.2,0.159091,0,80,unavailable,0.1,1,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268902,CSAG2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); skin: 58.8235% (minimum 65%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 65%, Baseline (adaptation disabled))",-0.0617647,-0.2,0.159091,0,80,unavailable,0.1,1,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268902,CSAG2,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 95.0000% (minimum 99%, Missing); basal ganglia: 95.0000% (minimum 99%, Missing); cerebral cortex: 97.4359% (minimum 99%, Missing); hippocampal formation: 92.6829% (minimum 99%, Missing); hypothalamus: 95.0000% (minimum 99%, Missing); kidney: 92.6829% (minimum 99%, Missing); liver: 97.4359% (minimum 99%, Missing); lung: 97.4359% (minimum 99%, Missing); lymph node: 74.5098% (minimum 97%, Missing); midbrain: 90.4762% (minimum 99%, Missing); skin: 80.8511% (minimum 95%, Missing); small intestine: 97.4359% (minimum 99%, Missing); spinal cord: 95.0000% (minimum 99%, Missing); spleen: 63.3333% (minimum 95%, Missing)",-0.316667,-0.224902,-0.0852381,0,80,unavailable,0.4,1.3,2.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268916,CSAG3,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"spleen: 63.3333% (minimum 65%, Missing)",-0.0166667,0.045098,0.154762,0,80,unavailable,0.4,1.3,2.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268916,CSAG3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"spleen: 63.3333% (minimum 65%, Missing)",-0.0166667,0.045098,0.154762,0,80,unavailable,0.4,1.3,2.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268916,CSAG3,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"spleen: 63.3333% (minimum 65%, Missing)",-0.0166667,0.045098,0.154762,0,80,unavailable,0.4,1.3,2.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268916,CSAG3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"spleen: 63.3333% (minimum 65%, Baseline (adaptation disabled))",-0.0166667,0.045098,0.154762,0,80,unavailable,0.4,1.3,2.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268916,CSAG3,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"amygdala: 95.0820% (minimum 99%, Missing); basal ganglia: 93.5484% (minimum 99%, Missing); cerebral cortex: 96.6667% (minimum 97%, Supported); hippocampal formation: 93.5484% (minimum 99%, Missing); hypothalamus: 95.0820% (minimum 99%, Missing); lung: 96.6667% (minimum 97%, Supported); midbrain: 95.8678% (minimum 99%, Missing); retina: 95.0820% (minimum 99%, Missing); spinal cord: 93.5484% (minimum 99%, Missing)",0.05,0.03,-0.0545161,0,3,partial,0.8,0,0,,skin 2 / epidermal cells: Low (Supported),53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 2 / epidermal cells,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000268940,CT45A1,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.185484,0,3,partial,0.8,0,0,,skin 2 / epidermal cells: Low (Supported),53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 2 / epidermal cells,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000268940,CT45A1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.185484,0,3,partial,0.8,0,0,,skin 2 / epidermal cells: Low (Supported),53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 2 / epidermal cells,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000268940,CT45A1,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.185484,0,3,partial,0.8,0,0,,skin 2 / epidermal cells: Low (Supported),53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 2 / epidermal cells,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000268940,CT45A1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.185484,0,3,partial,0.8,0,0,,skin 2 / epidermal cells: Low (Supported),53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 2 / epidermal cells,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000268940,CT45A1,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.5904% (minimum 99%, Missing); kidney: 95.2941% (minimum 99%, Missing); skeletal muscle: 94.1860% (minimum 99%, Missing)",0.0378049,0.03,-0.0481395,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268964,ERVV-2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.337805,0.3,0.19186,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268964,ERVV-2,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.337805,0.3,0.19186,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268964,ERVV-2,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.337805,0.3,0.19186,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268964,ERVV-2,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.337805,0.3,0.19186,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268964,ERVV-2,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268988,SPANXN2,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268988,SPANXN2,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268988,SPANXN2,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268988,SPANXN2,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000268988,SPANXN2,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 98.7590% (minimum 99%, Missing)",0.0375905,0.0279101,-0.00240951,0,80,unavailable,1.2,0.2,1.2,"retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268994,FAM236B,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.33759,0.29791,0.23759,0,80,unavailable,1.2,0.2,1.2,"retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268994,FAM236B,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.33759,0.29791,0.23759,0,80,unavailable,1.2,0.2,1.2,"retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268994,FAM236B,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.33759,0.29791,0.23759,0,80,unavailable,1.2,0.2,1.2,"retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268994,FAM236B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.33759,0.29791,0.23759,0,80,unavailable,1.2,0.2,1.2,"retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000268994,FAM236B,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0484152,0.03,0.01,0,2,partial,0.1,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269058,CALR3,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348415,0.3,0.25,0,2,partial,0.1,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269058,CALR3,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348415,0.3,0.25,0,2,partial,0.1,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269058,CALR3,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348415,0.3,0.25,0,2,partial,0.1,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269058,CALR3,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.348415,0.3,0.248415,0,2,partial,0.1,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269058,CALR3,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"amygdala: 81.4159% (minimum 99%, Missing); basal ganglia: 83.6364% (minimum 99%, Missing); cerebral cortex: 90.1961% (minimum 97%, Supported); choroid plexus: 97.8723% (minimum 99%, Missing); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 85.1852% (minimum 99%, Missing); lung: 95.8333% (minimum 97%, Supported); midbrain: 87.6190% (minimum 99%, Missing); pituitary gland: 96.8421% (minimum 99%, Missing); spinal cord: 84.4037% (minimum 99%, Missing)",0.05,0.03,-0.19,0,4,partial,2.3,0,0,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),52,not_established,not_triggered,,,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000269096,CT45A3,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.05,0,4,partial,2.3,0,0,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),52,not_established,not_triggered,,,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000269096,CT45A3,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.05,0,4,partial,2.3,0,0,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),52,not_established,not_triggered,,,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000269096,CT45A3,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.05,0,4,partial,2.3,0,0,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),52,not_established,not_triggered,,,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000269096,CT45A3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.05,0,4,partial,2.3,0,0,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),52,not_established,not_triggered,,,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,ENSG00000269096,CT45A3,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.6667% (minimum 99%, Missing); basal ganglia: 97.3684% (minimum 99%, Missing); cerebellum: 98.6667% (minimum 99%, Missing); choroid plexus: 96.7320% (minimum 99%, Missing); hypothalamus: 96.1039% (minimum 99%, Missing); lung: 98.6667% (minimum 99%, Missing); pituitary gland: 82.2222% (minimum 99%, Missing); retina: 96.7320% (minimum 99%, Missing)",0.05,0.0232886,-0.167778,0,80,unavailable,3.2,0.1,0,"pituitary gland: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269405,NXF2,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293289,0.0722222,0,80,unavailable,3.2,0.1,0,"pituitary gland: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269405,NXF2,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293289,0.0722222,0,80,unavailable,3.2,0.1,0,"pituitary gland: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269405,NXF2,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293289,0.0722222,0,80,unavailable,3.2,0.1,0,"pituitary gland: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269405,NXF2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293289,0.0722222,0,80,unavailable,3.2,0.1,0,"pituitary gland: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269405,NXF2,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.6667% (minimum 99%, Missing); basal ganglia: 98.0132% (minimum 99%, Missing); cerebellum: 98.0132% (minimum 99%, Missing); choroid plexus: 98.0132% (minimum 99%, Missing); hippocampal formation: 98.6667% (minimum 99%, Missing); hypothalamus: 96.1039% (minimum 99%, Missing); lung: 98.6667% (minimum 99%, Missing); pituitary gland: 86.0465% (minimum 99%, Missing); retina: 98.0132% (minimum 99%, Missing)",0.05,0.0232886,-0.129535,0,80,unavailable,2.4,0.1,0,"pituitary gland: 2.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269437,NXF2B,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293289,0.110465,0,80,unavailable,2.4,0.1,0,"pituitary gland: 2.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269437,NXF2B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293289,0.110465,0,80,unavailable,2.4,0.1,0,"pituitary gland: 2.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269437,NXF2B,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293289,0.110465,0,80,unavailable,2.4,0.1,0,"pituitary gland: 2.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269437,NXF2B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293289,0.110465,0,80,unavailable,2.4,0.1,0,"pituitary gland: 2.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269437,NXF2B,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.5294% (minimum 99%, Missing); amygdala: 78.1250% (minimum 99%, Missing); basal ganglia: 58.1395% (minimum 99%, Missing); cerebellum: 73.5294% (minimum 99%, Missing); cerebral cortex: 43.8596% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 92.5926% (minimum 97%, Missing); duodenum: 92.5926% (minimum 99%, Missing); esophagus: 96.1538% (minimum 97%, Missing); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 69.4444% (minimum 99%, Missing); kidney: 89.2857% (minimum 99%, Missing); lung: 92.5926% (minimum 99%, Missing); lymph node: 78.1250% (minimum 97%, Missing); midbrain: 89.2857% (minimum 99%, Missing); pancreas: 78.1250% (minimum 99%, Missing); parathyroid gland: 80.6452% (minimum 97%, Missing); pituitary gland: 59.5238% (minimum 99%, Missing); rectum: 89.2857% (minimum 97%, Missing); retina: 52.0833% (minimum 99%, Missing); salivary gland: 86.2069% (minimum 97%, Missing); skeletal muscle: 96.1538% (minimum 99%, Missing); small intestine: 86.2069% (minimum 99%, Missing); smooth muscle: 86.2069% (minimum 99%, Missing); spinal cord: 92.5926% (minimum 99%, Missing); spleen: 80.6452% (minimum 95%, Missing); stomach: 86.2069% (minimum 97%, Missing); thymus: 78.1250% (minimum 95%, Missing); thyroid gland: 54.3478% (minimum 95%, Missing); urinary bladder: 92.5926% (minimum 97%, Missing)",-0.406522,-0.18875,-0.551404,0,80,unavailable,3.2,0.7,2.1,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269502,DMRTC1,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.5294% (minimum 75%, Missing); basal ganglia: 58.1395% (minimum 75%, Missing); cerebellum: 73.5294% (minimum 75%, Missing); cerebral cortex: 43.8596% (minimum 75%, Missing); hypothalamus: 69.4444% (minimum 75%, Missing); pituitary gland: 59.5238% (minimum 75%, Missing); retina: 52.0833% (minimum 75%, Missing); thyroid gland: 54.3478% (minimum 65%, Missing)",-0.106522,0.08125,-0.311404,0,80,unavailable,3.2,0.7,2.1,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269502,DMRTC1,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.5294% (minimum 75%, Missing); basal ganglia: 58.1395% (minimum 75%, Missing); cerebellum: 73.5294% (minimum 75%, Missing); cerebral cortex: 43.8596% (minimum 75%, Missing); hypothalamus: 69.4444% (minimum 75%, Missing); pituitary gland: 59.5238% (minimum 75%, Missing); retina: 52.0833% (minimum 75%, Missing); thyroid gland: 54.3478% (minimum 65%, Missing)",-0.106522,0.08125,-0.311404,0,80,unavailable,3.2,0.7,2.1,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269502,DMRTC1,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.5294% (minimum 75%, Missing); basal ganglia: 58.1395% (minimum 75%, Missing); cerebellum: 73.5294% (minimum 75%, Missing); cerebral cortex: 43.8596% (minimum 75%, Missing); hypothalamus: 69.4444% (minimum 75%, Missing); pituitary gland: 59.5238% (minimum 75%, Missing); retina: 52.0833% (minimum 75%, Missing); thyroid gland: 54.3478% (minimum 65%, Missing)",-0.106522,0.08125,-0.311404,0,80,unavailable,3.2,0.7,2.1,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269502,DMRTC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.5294% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 58.1395% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 73.5294% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 43.8596% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 69.4444% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 59.5238% (minimum 75%, Baseline (adaptation disabled)); retina: 52.0833% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 54.3478% (minimum 65%, Baseline (adaptation disabled))",-0.106522,0.08125,-0.311404,0,80,unavailable,3.2,0.7,2.1,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269502,DMRTC1,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 93.9394% (minimum 99%, Missing); kidney: 90.1163% (minimum 99%, Missing)",0.0435897,0.0172611,-0.0888372,0,80,unavailable,1.7,0.2,0.1,"kidney: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269526,ERVV-1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34359,0.287261,0.151163,0,80,unavailable,1.7,0.2,0.1,"kidney: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269526,ERVV-1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34359,0.287261,0.151163,0,80,unavailable,1.7,0.2,0.1,"kidney: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269526,ERVV-1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34359,0.287261,0.151163,0,80,unavailable,1.7,0.2,0.1,"kidney: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269526,ERVV-1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34359,0.287261,0.151163,0,80,unavailable,1.7,0.2,0.1,"kidney: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269526,ERVV-1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)"
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 88.2353% (minimum 99%, Missing); basal ganglia: 93.7500% (minimum 99%, Missing); cerebral cortex: 94.7368% (minimum 97%, Supported); hippocampal formation: 86.5385% (minimum 99%, Missing); hypothalamus: 93.7500% (minimum 99%, Missing); midbrain: 92.7835% (minimum 99%, Missing); spinal cord: 89.1089% (minimum 99%, Missing)",0.05,0.03,-0.124615,0,3,partial,1.4,0,0,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269586,CT45A10,admission_only,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.115385,0,3,partial,1.4,0,0,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269586,CT45A10,selectivity_revised,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.115385,0,3,partial,1.4,0,0,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269586,CT45A10,grid_revised,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.115385,0,3,partial,1.4,0,0,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269586,CT45A10,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.115385,0,3,partial,1.4,0,0,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269586,CT45A10,current_fixed,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 96.2963% (minimum 97%, Supported)",0.05,0.03,-0.00703704,0,2,partial,0.1,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269791,SSX4B,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269791,SSX4B,selectivity_revised,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269791,SSX4B,grid_revised,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269791,SSX4B,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.212963,0,2,partial,0.1,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000269791,SSX4B,current_fixed,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.9899% (minimum 99%, Missing); lung: 98.9899% (minimum 99%, Missing); small intestine: 98.0000% (minimum 99%, Missing)",0.0107843,0.019899,-0.01,0,80,unavailable,0.2,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270379,HEATR9,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.310784,0.289899,0.23,0,80,unavailable,0.2,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270379,HEATR9,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.310784,0.289899,0.23,0,80,unavailable,0.2,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270379,HEATR9,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.310784,0.289899,0.23,0,80,unavailable,0.2,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270379,HEATR9,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.310784,0.289899,0.23,0,80,unavailable,0.2,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270379,HEATR9,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000270601,PRAMEF5,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000270601,PRAMEF5,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000270601,PRAMEF5,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000270601,PRAMEF5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000270601,PRAMEF5,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.9403% (minimum 99%, Missing)",0.0470874,0.0290272,-0.000597303,0,80,unavailable,1.1,0.1,0.3,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270806,C17orf50,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347087,0.299027,0.239403,0,80,unavailable,1.1,0.1,0.3,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270806,C17orf50,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347087,0.299027,0.239403,0,80,unavailable,1.1,0.1,0.3,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270806,C17orf50,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347087,0.299027,0.239403,0,80,unavailable,1.1,0.1,0.3,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270806,C17orf50,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347087,0.299027,0.239403,0,80,unavailable,1.1,0.1,0.3,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270806,C17orf50,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"basal ganglia: 88.8889% (minimum 99%, Missing); hypothalamus: 88.8889% (minimum 99%, Missing)",0.05,0.03,-0.101111,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270946,CT45A9,admission_only,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.138889,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270946,CT45A9,selectivity_revised,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.138889,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270946,CT45A9,grid_revised,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.138889,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270946,CT45A9,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.138889,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000270946,CT45A9,current_fixed,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.0429078,0.0159155,0.0029078,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000271321,CTAGE6,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342908,0.285915,0.242908,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000271321,CTAGE6,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342908,0.285915,0.242908,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000271321,CTAGE6,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342908,0.285915,0.242908,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000271321,CTAGE6,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.342908,0.285915,0.242908,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000271321,CTAGE6,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000271449,CT45A2,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000271449,CT45A2,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000271449,CT45A2,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000271449,CT45A2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000271449,CT45A2,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,13.8,"skin: 13.8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000272804,KRTAP10-7,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,13.8,"skin: 13.8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000272804,KRTAP10-7,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,13.8,"skin: 13.8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000272804,KRTAP10-7,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,13.8,"skin: 13.8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000272804,KRTAP10-7,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,13.8,"skin: 13.8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000272804,KRTAP10-7,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 98.7762% (minimum 99%, Missing); cerebral cortex: 98.7762% (minimum 99%, Missing); retina: 98.2609% (minimum 99%, Missing); small intestine: 98.9492% (minimum 99%, Missing)",0.0360384,0.0160384,-0.0073913,0,80,unavailable,1,0.8,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000272968,RBAK-RBAKDN,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.336038,0.286038,0.232609,0,80,unavailable,1,0.8,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000272968,RBAK-RBAKDN,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.336038,0.286038,0.232609,0,80,unavailable,1,0.8,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000272968,RBAK-RBAKDN,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.336038,0.286038,0.232609,0,80,unavailable,1,0.8,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000272968,RBAK-RBAKDN,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.336038,0.286038,0.232609,0,80,unavailable,1,0.8,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000272968,RBAK-RBAKDN,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.0290196,0.00706458,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273111,LYPD4,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.29902,0.247065,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273111,LYPD4,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.29902,0.247065,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273111,LYPD4,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.29902,0.247065,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273111,LYPD4,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.29902,0.247065,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273111,LYPD4,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000273313,RBAKDN,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000273313,RBAKDN,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000273313,RBAKDN,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000273313,RBAKDN,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000273313,RBAKDN,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lung: 80.0000% (minimum 97%, Supported)",0,0.03,-0.17,0,3,partial,0.1,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273696,CT45A7,admission_only,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.25,0.3,0.15,0,3,partial,0.1,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273696,CT45A7,selectivity_revised,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.25,0.3,0.15,0,3,partial,0.1,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273696,CT45A7,grid_revised,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.25,0.3,0.15,0,3,partial,0.1,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273696,CT45A7,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.15,0.3,0.05,0,3,partial,0.1,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273696,CT45A7,current_fixed,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.2206% (minimum 99%, Missing)",0.05,0.03,-0.00779359,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273976,GOLGA6L1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.232206,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273976,GOLGA6L1,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.232206,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273976,GOLGA6L1,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.232206,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273976,GOLGA6L1,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.232206,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000273976,GOLGA6L1,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274102,OR4M2,admission_only,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274102,OR4M2,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274102,OR4M2,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274102,OR4M2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274102,OR4M2,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 98.2759% (minimum 99%, Missing); duodenum: 96.6102% (minimum 99%, Missing); heart muscle: 98.2759% (minimum 99%, Missing); kidney: 98.2759% (minimum 99%, Missing); liver: 98.2759% (minimum 99%, Missing); pancreas: 98.2759% (minimum 99%, Missing); skeletal muscle: 96.6102% (minimum 99%, Missing); small intestine: 98.2759% (minimum 99%, Missing)",0.0161017,0.0127586,-0.04,0,80,unavailable,0.6,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274183,H2AB1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.316102,0.282759,0.2,0,80,unavailable,0.6,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274183,H2AB1,selectivity_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.316102,0.282759,0.2,0,80,unavailable,0.6,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274183,H2AB1,grid_revised,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.316102,0.282759,0.2,0,80,unavailable,0.6,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274183,H2AB1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.316102,0.282759,0.2,0,80,unavailable,0.6,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274183,H2AB1,current_fixed,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 92.5373% (minimum 99%, Missing)",0.042,0.022,-0.0646269,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274209,ANTXRL,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.342,0.292,0.175373,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274209,ANTXRL,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.342,0.292,0.175373,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274209,ANTXRL,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.342,0.292,0.175373,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274209,ANTXRL,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.342,0.292,0.175373,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274209,ANTXRL,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.4545% (minimum 99%, Missing)",0.05,0.03,-0.0154545,0,4,partial,1.4,0,0,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274274,GAGE13,admission_only,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224545,0,4,partial,1.4,0,0,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274274,GAGE13,selectivity_revised,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224545,0,4,partial,1.4,0,0,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274274,GAGE13,grid_revised,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224545,0,4,partial,1.4,0,0,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274274,GAGE13,current_adaptive,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224545,0,4,partial,1.4,0,0,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274274,GAGE13,current_fixed,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,1,partial,0,0.1,0.3,,,55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274391,TPTE,admission_only,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0.3,,,55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274391,TPTE,selectivity_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0.3,,,55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274391,TPTE,grid_revised,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0.3,,,55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274391,TPTE,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.347273,0.299089,0.25,0,1,partial,0,0.1,0.3,,,55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274391,TPTE,current_fixed,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 80.6818% (minimum 90%, Approved); adrenal gland: 69.6078% (minimum 98%, Approved); amygdala: 79.7753% (minimum 99%, Missing); basal ganglia: 73.9583% (minimum 99%, Missing); cerebellum: 50.3546% (minimum 98%, Approved); cerebral cortex: 73.9583% (minimum 98%, Approved); choroid plexus: 51.0791% (minimum 99%, Missing); colon: 75.5319% (minimum 97%, Missing); duodenum: 86.5854% (minimum 98%, Approved); esophagus: 63.9640% (minimum 95%, Approved); heart muscle: 82.5581% (minimum 98%, Approved); hippocampal formation: 79.7753% (minimum 99%, Missing); hypothalamus: 77.1739% (minimum 99%, Missing); kidney: 74.7368% (minimum 98%, Approved); liver: 68.2692% (minimum 98%, Approved); lung: 76.3441% (minimum 98%, Approved); lymph node: 94.6667% (minimum 95%, Approved); midbrain: 81.6092% (minimum 99%, Missing); pancreas: 73.1959% (minimum 99%, Missing); pituitary gland: 69.6078% (minimum 99%, Missing); rectum: 92.2078% (minimum 95%, Approved); retina: 76.3441% (minimum 99%, Missing); salivary gland: 69.6078% (minimum 95%, Approved); skeletal muscle: 78.8889% (minimum 98%, Approved); skin: 65.1376% (minimum 90%, Approved); small intestine: 63.3929% (minimum 98%, Approved); spinal cord: 84.5238% (minimum 99%, Missing); spleen: 63.3929% (minimum 90%, Approved); stomach: 75.5319% (minimum 95%, Approved); thyroid gland: 77.1739% (minimum 90%, Approved); urinary bladder: 67.6190% (minimum 97%, Missing)",-0.266071,-0.31036,-0.479209,0,2,partial,7,4,4.1,"cerebellum: 7 nTPM (vital, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); basal ganglia: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); colon: 2.3 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274419,TBC1D3D,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 69.6078% (minimum 70%, Approved); basal ganglia: 73.9583% (minimum 75%, Missing); cerebellum: 50.3546% (minimum 70%, Approved); choroid plexus: 51.0791% (minimum 75%, Missing); esophagus: 63.9640% (minimum 65%, Approved); liver: 68.2692% (minimum 70%, Approved); pancreas: 73.1959% (minimum 75%, Missing); pituitary gland: 69.6078% (minimum 75%, Missing); small intestine: 63.3929% (minimum 70%, Approved); urinary bladder: 67.6190% (minimum 70%, Missing)",0.0339286,-0.0238095,-0.239209,0,2,partial,7,4,4.1,"cerebellum: 7 nTPM (vital, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); basal ganglia: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); colon: 2.3 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274419,TBC1D3D,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 69.6078% (minimum 70%, Approved); basal ganglia: 73.9583% (minimum 75%, Missing); cerebellum: 50.3546% (minimum 70%, Approved); choroid plexus: 51.0791% (minimum 75%, Missing); esophagus: 63.9640% (minimum 65%, Approved); liver: 68.2692% (minimum 70%, Approved); pancreas: 73.1959% (minimum 75%, Missing); pituitary gland: 69.6078% (minimum 75%, Missing); small intestine: 63.3929% (minimum 70%, Approved); urinary bladder: 67.6190% (minimum 70%, Missing)",0.0339286,-0.0238095,-0.239209,0,2,partial,7,4,4.1,"cerebellum: 7 nTPM (vital, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 2); urinary bladder: 3.4 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); basal ganglia: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); lung: 2.2 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274419,TBC1D3D,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 69.6078% (minimum 70%, Approved); basal ganglia: 73.9583% (minimum 75%, Missing); cerebellum: 50.3546% (minimum 70%, Approved); choroid plexus: 51.0791% (minimum 75%, Missing); esophagus: 63.9640% (minimum 65%, Approved); liver: 68.2692% (minimum 70%, Approved); pancreas: 73.1959% (minimum 75%, Missing); pituitary gland: 69.6078% (minimum 75%, Missing); small intestine: 63.3929% (minimum 70%, Approved); urinary bladder: 67.6190% (minimum 70%, Missing)",0.0339286,-0.0238095,-0.239209,0,2,partial,7,4,4.1,"cerebellum: 7 nTPM (vital, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 2); urinary bladder: 3.4 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); basal ganglia: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); lung: 2.2 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274419,TBC1D3D,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 69.6078% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 73.9583% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 50.3546% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 73.9583% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 51.0791% (minimum 75%, Baseline (adaptation disabled)); esophagus: 63.9640% (minimum 70%, Baseline (adaptation disabled)); kidney: 74.7368% (minimum 75%, Baseline (adaptation disabled)); liver: 68.2692% (minimum 75%, Baseline (adaptation disabled)); pancreas: 73.1959% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 69.6078% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 69.6078% (minimum 70%, Baseline (adaptation disabled)); small intestine: 63.3929% (minimum 75%, Baseline (adaptation disabled)); spleen: 63.3929% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 67.6190% (minimum 70%, Baseline (adaptation disabled))",-0.0160714,-0.0603604,-0.246454,0,2,partial,7,4,4.1,"cerebellum: 7 nTPM (vital, limit 1); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274419,TBC1D3D,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0135036,0.03,0.0024812,0,7,partial,0.2,0.3,0.5,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274600,RIMBP3B,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.313504,0.3,0.242481,0,7,partial,0.2,0.3,0.5,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274600,RIMBP3B,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.313504,0.3,0.242481,0,7,partial,0.2,0.3,0.5,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274600,RIMBP3B,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.313504,0.3,0.242481,0,7,partial,0.2,0.3,0.5,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274600,RIMBP3B,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.313504,0.277778,0.235075,0,7,partial,0.2,0.3,0.5,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274600,RIMBP3B,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 20.0000% (minimum 99%, Missing); choroid plexus: 40.0000% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); esophagus: 66.6667% (minimum 97%, Missing); lymph node: 50.0000% (minimum 97%, Missing); thymus: 22.2222% (minimum 95%, Missing)",-0.727778,-0.47,-0.79,0,4,partial,0.8,0.2,0.7,,adipose tissue / adipocytes: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274618,H4C6,admission_only,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 20.0000% (minimum 75%, Missing); choroid plexus: 40.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); thymus: 22.2222% (minimum 65%, Missing)",-0.427778,-0.2,-0.55,0,4,partial,0.8,0.2,0.7,,adipose tissue / adipocytes: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274618,H4C6,selectivity_revised,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 20.0000% (minimum 75%, Missing); choroid plexus: 40.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); thymus: 22.2222% (minimum 65%, Missing)",-0.427778,-0.2,-0.55,0,4,partial,0.8,0.2,0.7,,adipose tissue / adipocytes: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274618,H4C6,grid_revised,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 20.0000% (minimum 75%, Missing); choroid plexus: 40.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); thymus: 22.2222% (minimum 65%, Missing)",-0.427778,-0.2,-0.55,0,4,partial,0.8,0.2,0.7,,adipose tissue / adipocytes: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274618,H4C6,current_adaptive,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 20.0000% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 40.0000% (minimum 75%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 70%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 70%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 70%, Baseline (adaptation disabled)); thymus: 22.2222% (minimum 65%, Baseline (adaptation disabled))",-0.427778,-0.2,-0.55,0,4,partial,0.8,0.2,0.7,,adipose tissue / adipocytes: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000274618,H4C6,current_fixed,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274764,PRAMEF27,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274764,PRAMEF27,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274764,PRAMEF27,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274764,PRAMEF27,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274764,PRAMEF27,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 98.5507% (minimum 99%, Missing); basal ganglia: 98.5507% (minimum 99%, Missing); bone marrow: 88.3117% (minimum 98%, Approved); cerebellum: 93.1507% (minimum 98%, Approved); choroid plexus: 97.1429% (minimum 99%, Missing); duodenum: 97.1429% (minimum 98%, Approved); hippocampal formation: 98.5507% (minimum 99%, Missing); hypothalamus: 98.5507% (minimum 99%, Missing); kidney: 97.1429% (minimum 98%, Approved); liver: 95.7746% (minimum 98%, Approved); midbrain: 98.5507% (minimum 99%, Missing); pancreas: 97.1429% (minimum 98%, Approved); pituitary gland: 97.1429% (minimum 99%, Missing); retina: 93.1507% (minimum 99%, Missing); salivary gland: 94.4444% (minimum 95%, Approved); skeletal muscle: 88.3117% (minimum 98%, Approved); small intestine: 95.7746% (minimum 98%, Approved); spinal cord: 98.5507% (minimum 99%, Missing)",0.0189189,-0.00555556,-0.0968831,0,4,partial,0.9,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274933,TBC1D3I,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.318919,0.285507,0.181507,0,4,partial,0.9,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274933,TBC1D3I,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.318919,0.285507,0.181507,0,4,partial,0.9,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274933,TBC1D3I,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.318919,0.285507,0.181507,0,4,partial,0.9,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274933,TBC1D3I,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.268919,0.244444,0.133117,0,4,partial,0.9,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000274933,TBC1D3I,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 89.0411% (minimum 99%, Missing); amygdala: 88.4354% (minimum 99%, Missing); basal ganglia: 87.8378% (minimum 99%, Missing); bone marrow: 97.7444% (minimum 99%, Missing); cerebellum: 84.4156% (minimum 99%, Missing); cerebral cortex: 83.3333% (minimum 99%, Missing); choroid plexus: 96.2963% (minimum 99%, Missing); heart muscle: 96.2963% (minimum 99%, Missing); hippocampal formation: 89.6552% (minimum 99%, Missing); hypothalamus: 81.2500% (minimum 99%, Missing); kidney: 98.4848% (minimum 99%, Missing); lung: 98.4848% (minimum 99%, Missing); lymph node: 92.8571% (minimum 97%, Missing); midbrain: 90.2778% (minimum 99%, Missing); pancreas: 96.2963% (minimum 99%, Missing); parathyroid gland: 92.1986% (minimum 97%, Missing); pituitary gland: 90.9091% (minimum 99%, Missing); retina: 80.2469% (minimum 99%, Missing); skeletal muscle: 97.7444% (minimum 99%, Missing); small intestine: 97.0149% (minimum 99%, Missing); smooth muscle: 94.2029% (minimum 99%, Missing); spinal cord: 90.2778% (minimum 99%, Missing); spleen: 93.5252% (minimum 95%, Missing); thymus: 94.2029% (minimum 95%, Missing); thyroid gland: 87.2483% (minimum 95%, Missing)",-0.0775168,-0.0480142,-0.187531,0,80,unavailable,3.2,1.1,1.9,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275004,ZNF280B,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.222483,0.221986,0.0524691,0,80,unavailable,3.2,1.1,1.9,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275004,ZNF280B,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.222483,0.221986,0.0524691,0,80,unavailable,3.2,1.1,1.9,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275004,ZNF280B,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.222483,0.221986,0.0524691,0,80,unavailable,3.2,1.1,1.9,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275004,ZNF280B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,rna_above_tissue_ceiling,True,True,True,,0.222483,0.221986,0.0524691,0,80,unavailable,3.2,1.1,1.9,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275004,ZNF280B,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.8525% (minimum 95%, Missing); adrenal gland: 62.6866% (minimum 99%, Missing); amygdala: 72.4138% (minimum 99%, Missing); basal ganglia: 70.0000% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 99%, Missing); cerebellum: 65.6250% (minimum 99%, Missing); cerebral cortex: 63.6364% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 64.6154% (minimum 97%, Missing); duodenum: 67.7419% (minimum 99%, Missing); esophagus: 65.6250% (minimum 97%, Missing); heart muscle: 59.1549% (minimum 99%, Missing); hippocampal formation: 71.1864% (minimum 99%, Missing); hypothalamus: 72.4138% (minimum 99%, Missing); kidney: 62.6866% (minimum 99%, Missing); liver: 70.0000% (minimum 99%, Missing); lung: 64.6154% (minimum 99%, Missing); lymph node: 59.1549% (minimum 97%, Missing); midbrain: 72.4138% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 53.1646% (minimum 97%, Missing); pituitary gland: 70.0000% (minimum 99%, Missing); rectum: 71.1864% (minimum 97%, Missing); retina: 60.8696% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 59.1549% (minimum 99%, Missing); skin: 60.0000% (minimum 95%, Missing); small intestine: 71.1864% (minimum 99%, Missing); smooth muscle: 62.6866% (minimum 99%, Missing); spinal cord: 70.0000% (minimum 99%, Missing); spleen: 60.8696% (minimum 95%, Missing); stomach: 64.6154% (minimum 97%, Missing); thymus: 57.5342% (minimum 95%, Missing); thyroid gland: 58.3333% (minimum 95%, Missing); tongue: 54.5455% (minimum 97%, Missing); urinary bladder: 65.6250% (minimum 97%, Missing)",-0.374658,-0.438354,-0.398451,0,80,unavailable,2.9,3.7,3.1,"parathyroid gland: 3.7 nTPM (protected, limit 2); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275111,ZNF2,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 62.6866% (minimum 75%, Missing); amygdala: 72.4138% (minimum 75%, Missing); basal ganglia: 70.0000% (minimum 75%, Missing); cerebellum: 65.6250% (minimum 75%, Missing); cerebral cortex: 63.6364% (minimum 75%, Missing); colon: 64.6154% (minimum 70%, Missing); duodenum: 67.7419% (minimum 75%, Missing); esophagus: 65.6250% (minimum 70%, Missing); heart muscle: 59.1549% (minimum 75%, Missing); hippocampal formation: 71.1864% (minimum 75%, Missing); hypothalamus: 72.4138% (minimum 75%, Missing); kidney: 62.6866% (minimum 75%, Missing); liver: 70.0000% (minimum 75%, Missing); lung: 64.6154% (minimum 75%, Missing); lymph node: 59.1549% (minimum 70%, Missing); midbrain: 72.4138% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 53.1646% (minimum 70%, Missing); pituitary gland: 70.0000% (minimum 75%, Missing); retina: 60.8696% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 59.1549% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 71.1864% (minimum 75%, Missing); smooth muscle: 62.6866% (minimum 75%, Missing); spinal cord: 70.0000% (minimum 75%, Missing); spleen: 60.8696% (minimum 65%, Missing); stomach: 64.6154% (minimum 70%, Missing); thymus: 57.5342% (minimum 65%, Missing); thyroid gland: 58.3333% (minimum 65%, Missing); tongue: 54.5455% (minimum 70%, Missing); urinary bladder: 65.6250% (minimum 70%, Missing)",-0.0746575,-0.168354,-0.158451,0,80,unavailable,2.9,3.7,3.1,"parathyroid gland: 3.7 nTPM (protected, limit 2); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275111,ZNF2,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 62.6866% (minimum 75%, Missing); amygdala: 72.4138% (minimum 75%, Missing); basal ganglia: 70.0000% (minimum 75%, Missing); cerebellum: 65.6250% (minimum 75%, Missing); cerebral cortex: 63.6364% (minimum 75%, Missing); colon: 64.6154% (minimum 70%, Missing); duodenum: 67.7419% (minimum 75%, Missing); esophagus: 65.6250% (minimum 70%, Missing); heart muscle: 59.1549% (minimum 75%, Missing); hippocampal formation: 71.1864% (minimum 75%, Missing); hypothalamus: 72.4138% (minimum 75%, Missing); kidney: 62.6866% (minimum 75%, Missing); liver: 70.0000% (minimum 75%, Missing); lung: 64.6154% (minimum 75%, Missing); lymph node: 59.1549% (minimum 70%, Missing); midbrain: 72.4138% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 53.1646% (minimum 70%, Missing); pituitary gland: 70.0000% (minimum 75%, Missing); retina: 60.8696% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 59.1549% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 71.1864% (minimum 75%, Missing); smooth muscle: 62.6866% (minimum 75%, Missing); spinal cord: 70.0000% (minimum 75%, Missing); spleen: 60.8696% (minimum 65%, Missing); stomach: 64.6154% (minimum 70%, Missing); thymus: 57.5342% (minimum 65%, Missing); thyroid gland: 58.3333% (minimum 65%, Missing); tongue: 54.5455% (minimum 70%, Missing); urinary bladder: 65.6250% (minimum 70%, Missing)",-0.0746575,-0.168354,-0.158451,0,80,unavailable,2.9,3.7,3.1,"parathyroid gland: 3.7 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275111,ZNF2,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 62.6866% (minimum 75%, Missing); amygdala: 72.4138% (minimum 75%, Missing); basal ganglia: 70.0000% (minimum 75%, Missing); cerebellum: 65.6250% (minimum 75%, Missing); cerebral cortex: 63.6364% (minimum 75%, Missing); colon: 64.6154% (minimum 70%, Missing); duodenum: 67.7419% (minimum 75%, Missing); esophagus: 65.6250% (minimum 70%, Missing); heart muscle: 59.1549% (minimum 75%, Missing); hippocampal formation: 71.1864% (minimum 75%, Missing); hypothalamus: 72.4138% (minimum 75%, Missing); kidney: 62.6866% (minimum 75%, Missing); liver: 70.0000% (minimum 75%, Missing); lung: 64.6154% (minimum 75%, Missing); lymph node: 59.1549% (minimum 70%, Missing); midbrain: 72.4138% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 53.1646% (minimum 70%, Missing); pituitary gland: 70.0000% (minimum 75%, Missing); retina: 60.8696% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 59.1549% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 71.1864% (minimum 75%, Missing); smooth muscle: 62.6866% (minimum 75%, Missing); spinal cord: 70.0000% (minimum 75%, Missing); spleen: 60.8696% (minimum 65%, Missing); stomach: 64.6154% (minimum 70%, Missing); thymus: 57.5342% (minimum 65%, Missing); thyroid gland: 58.3333% (minimum 65%, Missing); tongue: 54.5455% (minimum 70%, Missing); urinary bladder: 65.6250% (minimum 70%, Missing)",-0.0746575,-0.168354,-0.158451,0,80,unavailable,2.9,3.7,3.1,"parathyroid gland: 3.7 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275111,ZNF2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 62.6866% (minimum 75%, Baseline (adaptation disabled)); amygdala: 72.4138% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 70.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 65.6250% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.6364% (minimum 75%, Baseline (adaptation disabled)); colon: 64.6154% (minimum 70%, Baseline (adaptation disabled)); duodenum: 67.7419% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.6250% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 59.1549% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.1864% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 72.4138% (minimum 75%, Baseline (adaptation disabled)); kidney: 62.6866% (minimum 75%, Baseline (adaptation disabled)); liver: 70.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 64.6154% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.1549% (minimum 70%, Baseline (adaptation disabled)); midbrain: 72.4138% (minimum 75%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 53.1646% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 70.0000% (minimum 75%, Baseline (adaptation disabled)); retina: 60.8696% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 59.1549% (minimum 75%, Baseline (adaptation disabled)); skin: 60.0000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 71.1864% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.6866% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.8696% (minimum 65%, Baseline (adaptation disabled)); stomach: 64.6154% (minimum 70%, Baseline (adaptation disabled)); thymus: 57.5342% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 58.3333% (minimum 65%, Baseline (adaptation disabled)); tongue: 54.5455% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 65.6250% (minimum 70%, Baseline (adaptation disabled))",-0.0746575,-0.168354,-0.158451,0,80,unavailable,2.9,3.7,3.1,"parathyroid gland: 3.7 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275111,ZNF2,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 91.3669% (minimum 99%, Missing); stomach: 63.0273% (minimum 95%, Approved)",0.05,-0.319727,-0.0763309,0,4,partial,2.4,14.9,0.2,"stomach: 14.9 nTPM (protected, limit 4); retina: 2.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275113,GAGE2E,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 63.0273% (minimum 65%, Approved)",0.35,-0.019727,0.163669,0,4,partial,2.4,14.9,0.2,"stomach: 14.9 nTPM (protected, limit 4); retina: 2.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275113,GAGE2E,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 63.0273% (minimum 65%, Approved)",0.35,-0.019727,0.163669,0,4,partial,2.4,14.9,0.2,"stomach: 14.9 nTPM (protected, limit 4); retina: 2.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275113,GAGE2E,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 63.0273% (minimum 65%, Approved)",0.35,-0.019727,0.163669,0,4,partial,2.4,14.9,0.2,"stomach: 14.9 nTPM (protected, limit 4); retina: 2.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275113,GAGE2E,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 63.0273% (minimum 70%, Baseline (adaptation disabled))",0.342187,-0.069727,0.163669,0,4,partial,2.4,14.9,0.2,"stomach: 14.9 nTPM (protected, limit 3); retina: 2.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275113,GAGE2E,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.0395288,0.03,0.00473684,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275489,SPMAP1,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.339529,0.3,0.244737,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275489,SPMAP1,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.339529,0.3,0.244737,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275489,SPMAP1,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.339529,0.3,0.244737,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275489,SPMAP1,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.339529,0.3,0.244737,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275489,SPMAP1,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.0447264,0.0175654,0.00015748,0,80,unavailable,1.5,1.9,0.8,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000275520,FAM236A,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.344726,0.287565,0.240157,0,80,unavailable,1.5,1.9,0.8,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000275520,FAM236A,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.344726,0.287565,0.240157,0,80,unavailable,1.5,1.9,0.8,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000275520,FAM236A,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.344726,0.287565,0.240157,0,80,unavailable,1.5,1.9,0.8,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000275520,FAM236A,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.344726,0.287565,0.240157,0,80,unavailable,1.5,1.9,0.8,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000275520,FAM236A,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.00360341,0,1,partial,0.3,0.2,1.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275722,LYZL6,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.243603,0,1,partial,0.3,0.2,1.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275722,LYZL6,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.243603,0,1,partial,0.3,0.2,1.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275722,LYZL6,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.243603,0,1,partial,0.3,0.2,1.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275722,LYZL6,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.326939,0.295726,0.243603,0,1,partial,0.3,0.2,1.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275722,LYZL6,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275774,HNRNPCL2,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275774,HNRNPCL2,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275774,HNRNPCL2,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275774,HNRNPCL2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275774,HNRNPCL2,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.9247% (minimum 99%, Missing); hypothalamus: 98.9247% (minimum 99%, Missing)",0.015035,0.0263899,-0.000752688,0,7,partial,0.3,0.7,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275793,RIMBP3,admission_only,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.315035,0.29639,0.239247,0,7,partial,0.3,0.7,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275793,RIMBP3,selectivity_revised,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.315035,0.29639,0.239247,0,7,partial,0.3,0.7,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275793,RIMBP3,grid_revised,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.315035,0.29639,0.239247,0,7,partial,0.3,0.7,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275793,RIMBP3,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.315035,0.275265,0.239247,0,7,partial,0.3,0.7,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275793,RIMBP3,current_fixed,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 97.0588% (minimum 99%, Missing); basal ganglia: 98.5075% (minimum 99%, Missing); bone marrow: 97.0588% (minimum 99%, Missing); cerebellum: 91.6667% (minimum 99%, Missing); cerebral cortex: 98.5075% (minimum 99%, Missing); heart muscle: 98.5075% (minimum 99%, Missing); hippocampal formation: 98.5075% (minimum 99%, Missing); hypothalamus: 98.5075% (minimum 99%, Missing); kidney: 97.0588% (minimum 99%, Missing); liver: 97.0588% (minimum 99%, Missing); lung: 98.5075% (minimum 99%, Missing); pancreas: 98.5075% (minimum 99%, Missing); pituitary gland: 97.0588% (minimum 99%, Missing); skeletal muscle: 97.0588% (minimum 99%, Missing); small intestine: 97.0588% (minimum 99%, Missing)",0.00652174,0.000588235,-0.0733333,0,80,unavailable,0.6,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000275954,TBC1D3F,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.306522,0.270588,0.166667,0,80,unavailable,0.6,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000275954,TBC1D3F,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.306522,0.270588,0.166667,0,80,unavailable,0.6,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000275954,TBC1D3F,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.306522,0.270588,0.166667,0,80,unavailable,0.6,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000275954,TBC1D3F,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.306522,0.270588,0.166667,0,80,unavailable,0.6,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000275954,TBC1D3F,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275969,SPATA31A3,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275969,SPATA31A3,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275969,SPATA31A3,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275969,SPATA31A3,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000275969,SPATA31A3,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276040,SPATA31A7,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276040,SPATA31A7,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276040,SPATA31A7,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276040,SPATA31A7,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276040,SPATA31A7,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.5926% (minimum 95%, Missing); adrenal gland: 74.2424% (minimum 99%, Missing); amygdala: 62.8205% (minimum 99%, Missing); basal ganglia: 61.2500% (minimum 99%, Missing); bone marrow: 79.6748% (minimum 99%, Missing); cerebellum: 49.0000% (minimum 99%, Missing); cerebral cortex: 56.3218% (minimum 99%, Missing); choroid plexus: 79.6748% (minimum 99%, Missing); colon: 67.1233% (minimum 97%, Missing); duodenum: 85.2174% (minimum 99%, Missing); esophagus: 72.5926% (minimum 97%, Missing); heart muscle: 70.5036% (minimum 99%, Missing); hippocampal formation: 64.0523% (minimum 99%, Missing); hypothalamus: 61.2500% (minimum 99%, Missing); kidney: 72.0588% (minimum 99%, Missing); liver: 68.0556% (minimum 99%, Missing); lung: 75.3846% (minimum 99%, Missing); lymph node: 83.7607% (minimum 97%, Missing); midbrain: 61.2500% (minimum 99%, Missing); pancreas: 67.1233% (minimum 99%, Missing); parathyroid gland: 89.9083% (minimum 97%, Missing); pituitary gland: 68.5315% (minimum 99%, Missing); rectum: 78.4000% (minimum 97%, Missing); retina: 67.1233% (minimum 99%, Missing); salivary gland: 72.0588% (minimum 97%, Missing); skeletal muscle: 62.0253% (minimum 99%, Missing); skin: 68.0556% (minimum 95%, Missing); small intestine: 65.3333% (minimum 99%, Missing); smooth muscle: 87.5000% (minimum 99%, Missing); spinal cord: 61.6352% (minimum 99%, Missing); spleen: 64.9007% (minimum 95%, Missing); stomach: 70.5036% (minimum 97%, Missing); thymus: 85.9649% (minimum 95%, Missing); thyroid gland: 64.9007% (minimum 95%, Missing); tongue: 88.2883% (minimum 97%, Missing); urinary bladder: 67.1233% (minimum 97%, Missing)",-0.300993,-0.298767,-0.5,0,80,unavailable,10.2,4.8,5.3,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); thyroid gland: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); pancreas: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); esophagus: 3.7 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276234,TADA2A,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.2424% (minimum 75%, Missing); amygdala: 62.8205% (minimum 75%, Missing); basal ganglia: 61.2500% (minimum 75%, Missing); cerebellum: 49.0000% (minimum 75%, Missing); cerebral cortex: 56.3218% (minimum 75%, Missing); colon: 67.1233% (minimum 70%, Missing); heart muscle: 70.5036% (minimum 75%, Missing); hippocampal formation: 64.0523% (minimum 75%, Missing); hypothalamus: 61.2500% (minimum 75%, Missing); kidney: 72.0588% (minimum 75%, Missing); liver: 68.0556% (minimum 75%, Missing); midbrain: 61.2500% (minimum 75%, Missing); pancreas: 67.1233% (minimum 75%, Missing); pituitary gland: 68.5315% (minimum 75%, Missing); retina: 67.1233% (minimum 75%, Missing); skeletal muscle: 62.0253% (minimum 75%, Missing); small intestine: 65.3333% (minimum 75%, Missing); spinal cord: 61.6352% (minimum 75%, Missing); spleen: 64.9007% (minimum 65%, Missing); thyroid gland: 64.9007% (minimum 65%, Missing); urinary bladder: 67.1233% (minimum 70%, Missing)",-0.000993377,-0.0287671,-0.26,0,80,unavailable,10.2,4.8,5.3,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); thyroid gland: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); pancreas: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); esophagus: 3.7 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276234,TADA2A,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.2424% (minimum 75%, Missing); amygdala: 62.8205% (minimum 75%, Missing); basal ganglia: 61.2500% (minimum 75%, Missing); cerebellum: 49.0000% (minimum 75%, Missing); cerebral cortex: 56.3218% (minimum 75%, Missing); colon: 67.1233% (minimum 70%, Missing); heart muscle: 70.5036% (minimum 75%, Missing); hippocampal formation: 64.0523% (minimum 75%, Missing); hypothalamus: 61.2500% (minimum 75%, Missing); kidney: 72.0588% (minimum 75%, Missing); liver: 68.0556% (minimum 75%, Missing); midbrain: 61.2500% (minimum 75%, Missing); pancreas: 67.1233% (minimum 75%, Missing); pituitary gland: 68.5315% (minimum 75%, Missing); retina: 67.1233% (minimum 75%, Missing); skeletal muscle: 62.0253% (minimum 75%, Missing); small intestine: 65.3333% (minimum 75%, Missing); spinal cord: 61.6352% (minimum 75%, Missing); spleen: 64.9007% (minimum 65%, Missing); thyroid gland: 64.9007% (minimum 65%, Missing); urinary bladder: 67.1233% (minimum 70%, Missing)",-0.000993377,-0.0287671,-0.26,0,80,unavailable,10.2,4.8,5.3,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); spleen: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); colon: 4.8 nTPM (protected, limit 3); retina: 4.8 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); esophagus: 3.7 nTPM (protected, limit 3); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276234,TADA2A,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.2424% (minimum 75%, Missing); amygdala: 62.8205% (minimum 75%, Missing); basal ganglia: 61.2500% (minimum 75%, Missing); cerebellum: 49.0000% (minimum 75%, Missing); cerebral cortex: 56.3218% (minimum 75%, Missing); colon: 67.1233% (minimum 70%, Missing); heart muscle: 70.5036% (minimum 75%, Missing); hippocampal formation: 64.0523% (minimum 75%, Missing); hypothalamus: 61.2500% (minimum 75%, Missing); kidney: 72.0588% (minimum 75%, Missing); liver: 68.0556% (minimum 75%, Missing); midbrain: 61.2500% (minimum 75%, Missing); pancreas: 67.1233% (minimum 75%, Missing); pituitary gland: 68.5315% (minimum 75%, Missing); retina: 67.1233% (minimum 75%, Missing); skeletal muscle: 62.0253% (minimum 75%, Missing); small intestine: 65.3333% (minimum 75%, Missing); spinal cord: 61.6352% (minimum 75%, Missing); spleen: 64.9007% (minimum 65%, Missing); thyroid gland: 64.9007% (minimum 65%, Missing); urinary bladder: 67.1233% (minimum 70%, Missing)",-0.000993377,-0.0287671,-0.26,0,80,unavailable,10.2,4.8,5.3,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); spleen: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); colon: 4.8 nTPM (protected, limit 3); retina: 4.8 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); esophagus: 3.7 nTPM (protected, limit 3); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276234,TADA2A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.2424% (minimum 75%, Baseline (adaptation disabled)); amygdala: 62.8205% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 61.2500% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 49.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 56.3218% (minimum 75%, Baseline (adaptation disabled)); colon: 67.1233% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 70.5036% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 64.0523% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 61.2500% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.0588% (minimum 75%, Baseline (adaptation disabled)); liver: 68.0556% (minimum 75%, Baseline (adaptation disabled)); midbrain: 61.2500% (minimum 75%, Baseline (adaptation disabled)); pancreas: 67.1233% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 68.5315% (minimum 75%, Baseline (adaptation disabled)); retina: 67.1233% (minimum 75%, Baseline (adaptation disabled)); skeletal muscle: 62.0253% (minimum 75%, Baseline (adaptation disabled)); small intestine: 65.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 61.6352% (minimum 75%, Baseline (adaptation disabled)); spleen: 64.9007% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 64.9007% (minimum 65%, Baseline (adaptation disabled)); urinary bladder: 67.1233% (minimum 70%, Baseline (adaptation disabled))",-0.000993377,-0.0287671,-0.26,0,80,unavailable,10.2,4.8,5.3,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); spleen: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); colon: 4.8 nTPM (protected, limit 3); retina: 4.8 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); esophagus: 3.7 nTPM (protected, limit 3); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276234,TADA2A,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276240,OR4E1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276240,OR4E1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276240,OR4E1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276240,OR4E1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276240,OR4E1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 56.5217% (minimum 99%, Missing); choroid plexus: 72.2222% (minimum 99%, Missing); colon: 92.8571% (minimum 97%, Missing); duodenum: 92.8571% (minimum 99%, Missing); esophagus: 92.8571% (minimum 97%, Missing); lymph node: 86.6667% (minimum 97%, Missing); retina: 92.8571% (minimum 99%, Missing); skeletal muscle: 86.6667% (minimum 99%, Missing); small intestine: 92.8571% (minimum 99%, Missing); spinal cord: 92.8571% (minimum 99%, Missing); spleen: 92.8571% (minimum 95%, Missing); thymus: 56.5217% (minimum 95%, Missing)",-0.384783,-0.103333,-0.424783,0,4,partial,1,0.2,1,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276410,H2BC3,admission_only,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 56.5217% (minimum 75%, Missing); choroid plexus: 72.2222% (minimum 75%, Missing); thymus: 56.5217% (minimum 65%, Missing)",-0.0847826,0.166667,-0.184783,0,4,partial,1,0.2,1,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276410,H2BC3,selectivity_revised,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 56.5217% (minimum 75%, Missing); choroid plexus: 72.2222% (minimum 75%, Missing); thymus: 56.5217% (minimum 65%, Missing)",-0.0847826,0.166667,-0.184783,0,4,partial,1,0.2,1,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276410,H2BC3,grid_revised,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 56.5217% (minimum 75%, Missing); choroid plexus: 72.2222% (minimum 75%, Missing); thymus: 56.5217% (minimum 65%, Missing)",-0.0847826,0.166667,-0.184783,0,4,partial,1,0.2,1,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276410,H2BC3,current_adaptive,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 56.5217% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 72.2222% (minimum 75%, Baseline (adaptation disabled)); thymus: 56.5217% (minimum 65%, Baseline (adaptation disabled))",-0.0847826,0.166667,-0.184783,0,4,partial,1,0.2,1,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276410,H2BC3,current_fixed,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 32.7982% (minimum 97%, Missing); salivary gland: 48.9726% (minimum 97%, Missing); skeletal muscle: 98.6207% (minimum 99%, Missing); skin: 25.3097% (minimum 95%, Missing); small intestine: 89.9371% (minimum 99%, Missing)",-0.696903,-0.642018,-0.0906289,0,80,unavailable,1.6,29.3,42.2,"skin: 42.2 nTPM (manageable, limit 5); esophagus: 29.3 nTPM (protected, limit 2); salivary gland: 14.9 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276430,FAM25C,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 32.7982% (minimum 70%, Missing); salivary gland: 48.9726% (minimum 70%, Missing); skin: 25.3097% (minimum 65%, Missing)",-0.396903,-0.372018,0.149371,0,80,unavailable,1.6,29.3,42.2,"skin: 42.2 nTPM (manageable, limit 5); esophagus: 29.3 nTPM (protected, limit 2); salivary gland: 14.9 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276430,FAM25C,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 32.7982% (minimum 70%, Missing); salivary gland: 48.9726% (minimum 70%, Missing); skin: 25.3097% (minimum 65%, Missing)",-0.396903,-0.372018,0.149371,0,80,unavailable,1.6,29.3,42.2,"skin: 42.2 nTPM (manageable, limit 5); esophagus: 29.3 nTPM (protected, limit 3); salivary gland: 14.9 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276430,FAM25C,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 32.7982% (minimum 70%, Missing); salivary gland: 48.9726% (minimum 70%, Missing); skin: 25.3097% (minimum 65%, Missing)",-0.396903,-0.372018,0.149371,0,80,unavailable,1.6,29.3,42.2,"skin: 42.2 nTPM (manageable, limit 5); esophagus: 29.3 nTPM (protected, limit 3); salivary gland: 14.9 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276430,FAM25C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 32.7982% (minimum 70%, Baseline (adaptation disabled)); salivary gland: 48.9726% (minimum 70%, Baseline (adaptation disabled)); skin: 25.3097% (minimum 65%, Baseline (adaptation disabled))",-0.396903,-0.372018,0.149371,0,80,unavailable,1.6,29.3,42.2,"skin: 42.2 nTPM (manageable, limit 5); esophagus: 29.3 nTPM (protected, limit 3); salivary gland: 14.9 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276430,FAM25C,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276581,SPATA31A5,admission_only,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276581,SPATA31A5,selectivity_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276581,SPATA31A5,grid_revised,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276581,SPATA31A5,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000276581,SPATA31A5,current_fixed,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276747,PADI6,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276747,PADI6,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276747,PADI6,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276747,PADI6,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276747,PADI6,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276950,GSTT4,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276950,GSTT4,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276950,GSTT4,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276950,GSTT4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000276950,GSTT4,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000277322,GOLGA6L6,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000277322,GOLGA6L6,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000277322,GOLGA6L6,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000277322,GOLGA6L6,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000277322,GOLGA6L6,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 95%, Missing); adrenal gland: 62.1622% (minimum 99%, Missing); amygdala: 69.6970% (minimum 99%, Missing); basal ganglia: 71.8750% (minimum 99%, Missing); bone marrow: 82.1429% (minimum 99%, Uncertain); cerebellum: 51.1111% (minimum 99%, Missing); cerebral cortex: 58.9744% (minimum 99%, Missing); choroid plexus: 79.3103% (minimum 99%, Missing); colon: 60.5263% (minimum 97%, Missing); duodenum: 69.6970% (minimum 99%, Missing); esophagus: 65.7143% (minimum 97%, Missing); heart muscle: 69.6970% (minimum 99%, Missing); hippocampal formation: 71.8750% (minimum 99%, Missing); hypothalamus: 67.6471% (minimum 99%, Missing); kidney: 57.5000% (minimum 99%, Missing); liver: 58.9744% (minimum 99%, Uncertain); lung: 60.5263% (minimum 99%, Missing); lymph node: 62.1622% (minimum 97%, Missing); midbrain: 71.8750% (minimum 99%, Missing); pancreas: 56.0976% (minimum 99%, Missing); parathyroid gland: 60.5263% (minimum 97%, Missing); pituitary gland: 69.6970% (minimum 99%, Missing); rectum: 63.8889% (minimum 97%, Missing); retina: 52.2727% (minimum 99%, Missing); salivary gland: 60.5263% (minimum 97%, Missing); skeletal muscle: 71.8750% (minimum 99%, Missing); skin: 62.1622% (minimum 95%, Missing); small intestine: 60.5263% (minimum 99%, Missing); smooth muscle: 58.9744% (minimum 99%, Missing); spinal cord: 69.6970% (minimum 99%, Missing); spleen: 62.1622% (minimum 95%, Missing); stomach: 53.4884% (minimum 97%, Missing); thymus: 56.0976% (minimum 95%, Missing); thyroid gland: 62.1622% (minimum 95%, Missing); tongue: 62.1622% (minimum 97%, Missing); urinary bladder: 58.9744% (minimum 97%, Missing)",-0.438889,-0.435116,-0.478889,0,0,routine_complete,2.2,2,2.2,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000277462,ZNF670,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 65%, Missing); adrenal gland: 62.1622% (minimum 75%, Missing); amygdala: 69.6970% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); cerebellum: 51.1111% (minimum 75%, Missing); cerebral cortex: 58.9744% (minimum 75%, Missing); colon: 60.5263% (minimum 70%, Missing); duodenum: 69.6970% (minimum 75%, Missing); esophagus: 65.7143% (minimum 70%, Missing); heart muscle: 69.6970% (minimum 75%, Missing); hippocampal formation: 71.8750% (minimum 75%, Missing); hypothalamus: 67.6471% (minimum 75%, Missing); kidney: 57.5000% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Uncertain); lung: 60.5263% (minimum 75%, Missing); lymph node: 62.1622% (minimum 70%, Missing); midbrain: 71.8750% (minimum 75%, Missing); pancreas: 56.0976% (minimum 75%, Missing); parathyroid gland: 60.5263% (minimum 70%, Missing); pituitary gland: 69.6970% (minimum 75%, Missing); rectum: 63.8889% (minimum 70%, Missing); retina: 52.2727% (minimum 75%, Missing); salivary gland: 60.5263% (minimum 70%, Missing); skeletal muscle: 71.8750% (minimum 75%, Missing); skin: 62.1622% (minimum 65%, Missing); small intestine: 60.5263% (minimum 75%, Missing); smooth muscle: 58.9744% (minimum 75%, Missing); spinal cord: 69.6970% (minimum 75%, Missing); spleen: 62.1622% (minimum 65%, Missing); stomach: 53.4884% (minimum 70%, Missing); thymus: 56.0976% (minimum 65%, Missing); thyroid gland: 62.1622% (minimum 65%, Missing); tongue: 62.1622% (minimum 70%, Missing); urinary bladder: 58.9744% (minimum 70%, Missing)",-0.138889,-0.165116,-0.238889,0,0,routine_complete,2.2,2,2.2,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000277462,ZNF670,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 65%, Missing); adrenal gland: 62.1622% (minimum 75%, Missing); amygdala: 69.6970% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); cerebellum: 51.1111% (minimum 75%, Missing); cerebral cortex: 58.9744% (minimum 75%, Missing); colon: 60.5263% (minimum 70%, Missing); duodenum: 69.6970% (minimum 75%, Missing); esophagus: 65.7143% (minimum 70%, Missing); heart muscle: 69.6970% (minimum 75%, Missing); hippocampal formation: 71.8750% (minimum 75%, Missing); hypothalamus: 67.6471% (minimum 75%, Missing); kidney: 57.5000% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Uncertain); lung: 60.5263% (minimum 75%, Missing); lymph node: 62.1622% (minimum 70%, Missing); midbrain: 71.8750% (minimum 75%, Missing); pancreas: 56.0976% (minimum 75%, Missing); parathyroid gland: 60.5263% (minimum 70%, Missing); pituitary gland: 69.6970% (minimum 75%, Missing); rectum: 63.8889% (minimum 70%, Missing); retina: 52.2727% (minimum 75%, Missing); salivary gland: 60.5263% (minimum 70%, Missing); skeletal muscle: 71.8750% (minimum 75%, Missing); skin: 62.1622% (minimum 65%, Missing); small intestine: 60.5263% (minimum 75%, Missing); smooth muscle: 58.9744% (minimum 75%, Missing); spinal cord: 69.6970% (minimum 75%, Missing); spleen: 62.1622% (minimum 65%, Missing); stomach: 53.4884% (minimum 70%, Missing); thymus: 56.0976% (minimum 65%, Missing); thyroid gland: 62.1622% (minimum 65%, Missing); tongue: 62.1622% (minimum 70%, Missing); urinary bladder: 58.9744% (minimum 70%, Missing)",-0.138889,-0.165116,-0.238889,0,0,routine_complete,2.2,2,2.2,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000277462,ZNF670,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 65%, Missing); adrenal gland: 62.1622% (minimum 75%, Missing); amygdala: 69.6970% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); cerebellum: 51.1111% (minimum 75%, Missing); cerebral cortex: 58.9744% (minimum 75%, Missing); colon: 60.5263% (minimum 70%, Missing); duodenum: 69.6970% (minimum 75%, Missing); esophagus: 65.7143% (minimum 70%, Missing); heart muscle: 69.6970% (minimum 75%, Missing); hippocampal formation: 71.8750% (minimum 75%, Missing); hypothalamus: 67.6471% (minimum 75%, Missing); kidney: 57.5000% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Uncertain); lung: 60.5263% (minimum 75%, Missing); lymph node: 62.1622% (minimum 70%, Missing); midbrain: 71.8750% (minimum 75%, Missing); pancreas: 56.0976% (minimum 75%, Missing); parathyroid gland: 60.5263% (minimum 70%, Missing); pituitary gland: 69.6970% (minimum 75%, Missing); rectum: 63.8889% (minimum 70%, Missing); retina: 52.2727% (minimum 75%, Missing); salivary gland: 60.5263% (minimum 70%, Missing); skeletal muscle: 71.8750% (minimum 75%, Missing); skin: 62.1622% (minimum 65%, Missing); small intestine: 60.5263% (minimum 75%, Missing); smooth muscle: 58.9744% (minimum 75%, Missing); spinal cord: 69.6970% (minimum 75%, Missing); spleen: 62.1622% (minimum 65%, Missing); stomach: 53.4884% (minimum 70%, Missing); thymus: 56.0976% (minimum 65%, Missing); thyroid gland: 62.1622% (minimum 65%, Missing); tongue: 62.1622% (minimum 70%, Missing); urinary bladder: 58.9744% (minimum 70%, Missing)",-0.138889,-0.165116,-0.238889,0,0,routine_complete,2.2,2,2.2,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000277462,ZNF670,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 62.1622% (minimum 75%, Baseline (adaptation disabled)); amygdala: 69.6970% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 71.8750% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 51.1111% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 58.9744% (minimum 75%, Baseline (adaptation disabled)); colon: 60.5263% (minimum 70%, Baseline (adaptation disabled)); duodenum: 69.6970% (minimum 75%, Baseline (adaptation disabled)); esophagus: 65.7143% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 69.6970% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 71.8750% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 67.6471% (minimum 75%, Baseline (adaptation disabled)); kidney: 57.5000% (minimum 75%, Baseline (adaptation disabled)); liver: 58.9744% (minimum 75%, Baseline (adaptation disabled)); lung: 60.5263% (minimum 75%, Baseline (adaptation disabled)); lymph node: 62.1622% (minimum 70%, Baseline (adaptation disabled)); midbrain: 71.8750% (minimum 75%, Baseline (adaptation disabled)); pancreas: 56.0976% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 60.5263% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 69.6970% (minimum 75%, Baseline (adaptation disabled)); rectum: 63.8889% (minimum 70%, Baseline (adaptation disabled)); retina: 52.2727% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 60.5263% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 71.8750% (minimum 75%, Baseline (adaptation disabled)); skin: 62.1622% (minimum 65%, Baseline (adaptation disabled)); small intestine: 60.5263% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 58.9744% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 69.6970% (minimum 75%, Baseline (adaptation disabled)); spleen: 62.1622% (minimum 65%, Baseline (adaptation disabled)); stomach: 53.4884% (minimum 70%, Baseline (adaptation disabled)); thymus: 56.0976% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 62.1622% (minimum 65%, Baseline (adaptation disabled)); tongue: 62.1622% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 58.9744% (minimum 70%, Baseline (adaptation disabled))",-0.138889,-0.165116,-0.238889,0,0,routine_complete,2.2,2,2.2,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000277462,ZNF670,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277535,CT47C1,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277535,CT47C1,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277535,CT47C1,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277535,CT47C1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277535,CT47C1,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 96.8254% (minimum 99%, Missing); heart muscle: 98.7055% (minimum 99%, Missing); kidney: 98.3871% (minimum 99%, Missing); small intestine: 98.0707% (minimum 99%, Missing)",0.00611285,0.0107074,-0.021746,0,80,unavailable,1,0.6,1.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277745,H2AB3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.306113,0.280707,0.218254,0,80,unavailable,1,0.6,1.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277745,H2AB3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.306113,0.280707,0.218254,0,80,unavailable,1,0.6,1.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277745,H2AB3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.306113,0.280707,0.218254,0,80,unavailable,1,0.6,1.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277745,H2AB3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.306113,0.280707,0.218254,0,80,unavailable,1,0.6,1.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277745,H2AB3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebral cortex: 98.7952% (minimum 99%, Missing)",0.05,0.03,-0.00204819,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277865,GOLGA6L22,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.237952,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277865,GOLGA6L22,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.237952,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277865,GOLGA6L22,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.237952,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277865,GOLGA6L22,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.237952,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000277865,GOLGA6L22,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 98.8636% (minimum 99%, Missing)",0.0386364,0.03,-0.00136364,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278057,TEX28,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.338636,0.3,0.238636,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278057,TEX28,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.338636,0.3,0.238636,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278057,TEX28,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.338636,0.3,0.238636,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278057,TEX28,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.338636,0.3,0.238636,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278057,TEX28,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"basal ganglia: 90.9091% (minimum 99%, Missing); hypothalamus: 90.9091% (minimum 99%, Missing)",0.05,0.03,-0.0809091,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278085,CT45A8,admission_only,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.159091,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278085,CT45A8,selectivity_revised,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.159091,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278085,CT45A8,grid_revised,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.159091,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278085,CT45A8,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.159091,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278085,CT45A8,current_fixed,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 14.2857% (minimum 99%, Missing); basal ganglia: 2.5000% (minimum 99%, Missing); cerebral cortex: 33.3333% (minimum 97%, Supported); hippocampal formation: 20.0000% (minimum 99%, Missing); hypothalamus: 7.6923% (minimum 99%, Missing); midbrain: 33.3333% (minimum 99%, Missing); pituitary gland: 7.6923% (minimum 99%, Missing); retina: 33.3333% (minimum 99%, Missing); spinal cord: 20.0000% (minimum 99%, Missing)",0.05,0.03,-0.965,0,3,partial,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278289,CT45A6,admission_only,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 14.2857% (minimum 75%, Missing); basal ganglia: 2.5000% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 65%, Supported); hippocampal formation: 20.0000% (minimum 75%, Missing); hypothalamus: 7.6923% (minimum 75%, Missing); midbrain: 33.3333% (minimum 75%, Missing); pituitary gland: 7.6923% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); spinal cord: 20.0000% (minimum 75%, Missing)",0.35,0.3,-0.725,0,3,partial,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278289,CT45A6,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 14.2857% (minimum 75%, Missing); basal ganglia: 2.5000% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 65%, Supported); hippocampal formation: 20.0000% (minimum 75%, Missing); hypothalamus: 7.6923% (minimum 75%, Missing); midbrain: 33.3333% (minimum 75%, Missing); pituitary gland: 7.6923% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); spinal cord: 20.0000% (minimum 75%, Missing)",0.35,0.3,-0.725,0,3,partial,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278289,CT45A6,grid_revised,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 14.2857% (minimum 75%, Missing); basal ganglia: 2.5000% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 65%, Supported); hippocampal formation: 20.0000% (minimum 75%, Missing); hypothalamus: 7.6923% (minimum 75%, Missing); midbrain: 33.3333% (minimum 75%, Missing); pituitary gland: 7.6923% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); spinal cord: 20.0000% (minimum 75%, Missing)",0.35,0.3,-0.725,0,3,partial,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278289,CT45A6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 14.2857% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 2.5000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 33.3333% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 20.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 7.6923% (minimum 75%, Baseline (adaptation disabled)); midbrain: 33.3333% (minimum 75%, Baseline (adaptation disabled)); pituitary gland: 7.6923% (minimum 75%, Baseline (adaptation disabled)); retina: 33.3333% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 20.0000% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.725,0,3,partial,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278289,CT45A6,current_fixed,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Missing); adrenal gland: 56.7568% (minimum 99%, Missing); amygdala: 65.6250% (minimum 99%, Missing); basal ganglia: 60.0000% (minimum 99%, Missing); bone marrow: 95.4545% (minimum 99%, Missing); cerebellum: 70.0000% (minimum 99%, Missing); cerebral cortex: 61.7647% (minimum 99%, Missing); choroid plexus: 60.0000% (minimum 99%, Missing); colon: 70.0000% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 75.0000% (minimum 97%, Missing); heart muscle: 60.0000% (minimum 99%, Missing); hippocampal formation: 70.0000% (minimum 99%, Missing); hypothalamus: 65.6250% (minimum 99%, Missing); kidney: 72.4138% (minimum 99%, Missing); liver: 77.7778% (minimum 99%, Missing); lung: 80.7692% (minimum 99%, Missing); lymph node: 87.5000% (minimum 97%, Missing); midbrain: 65.6250% (minimum 99%, Missing); pancreas: 75.0000% (minimum 99%, Missing); parathyroid gland: 44.6809% (minimum 97%, Missing); pituitary gland: 63.6364% (minimum 99%, Missing); rectum: 95.4545% (minimum 97%, Missing); retina: 32.8125% (minimum 99%, Missing); salivary gland: 75.0000% (minimum 97%, Missing); skeletal muscle: 75.0000% (minimum 99%, Missing); skin: 87.5000% (minimum 95%, Missing); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 72.4138% (minimum 99%, Missing); spinal cord: 70.0000% (minimum 99%, Missing); spleen: 77.7778% (minimum 95%, Missing); stomach: 77.7778% (minimum 97%, Missing); thymus: 65.6250% (minimum 95%, Missing); thyroid gland: 52.5000% (minimum 95%, Missing); tongue: 65.6250% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.425,-0.523191,-0.661875,0,80,unavailable,4.3,2.6,1.9,"retina: 4.3 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278318,ZNF229,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 56.7568% (minimum 75%, Missing); amygdala: 65.6250% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 61.7647% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 70.0000% (minimum 75%, Missing); hypothalamus: 65.6250% (minimum 75%, Missing); kidney: 72.4138% (minimum 75%, Missing); midbrain: 65.6250% (minimum 75%, Missing); parathyroid gland: 44.6809% (minimum 70%, Missing); pituitary gland: 63.6364% (minimum 75%, Missing); retina: 32.8125% (minimum 75%, Missing); smooth muscle: 72.4138% (minimum 75%, Missing); spinal cord: 70.0000% (minimum 75%, Missing); thyroid gland: 52.5000% (minimum 65%, Missing); tongue: 65.6250% (minimum 70%, Missing)",-0.125,-0.253191,-0.421875,0,80,unavailable,4.3,2.6,1.9,"retina: 4.3 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278318,ZNF229,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 56.7568% (minimum 75%, Missing); amygdala: 65.6250% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 61.7647% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 70.0000% (minimum 75%, Missing); hypothalamus: 65.6250% (minimum 75%, Missing); kidney: 72.4138% (minimum 75%, Missing); midbrain: 65.6250% (minimum 75%, Missing); parathyroid gland: 44.6809% (minimum 70%, Missing); pituitary gland: 63.6364% (minimum 75%, Missing); retina: 32.8125% (minimum 75%, Missing); smooth muscle: 72.4138% (minimum 75%, Missing); spinal cord: 70.0000% (minimum 75%, Missing); thyroid gland: 52.5000% (minimum 65%, Missing); tongue: 65.6250% (minimum 70%, Missing)",-0.125,-0.253191,-0.421875,0,80,unavailable,4.3,2.6,1.9,"retina: 4.3 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278318,ZNF229,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 56.7568% (minimum 75%, Missing); amygdala: 65.6250% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 61.7647% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 70.0000% (minimum 75%, Missing); hypothalamus: 65.6250% (minimum 75%, Missing); kidney: 72.4138% (minimum 75%, Missing); midbrain: 65.6250% (minimum 75%, Missing); parathyroid gland: 44.6809% (minimum 70%, Missing); pituitary gland: 63.6364% (minimum 75%, Missing); retina: 32.8125% (minimum 75%, Missing); smooth muscle: 72.4138% (minimum 75%, Missing); spinal cord: 70.0000% (minimum 75%, Missing); thyroid gland: 52.5000% (minimum 65%, Missing); tongue: 65.6250% (minimum 70%, Missing)",-0.125,-0.253191,-0.421875,0,80,unavailable,4.3,2.6,1.9,"retina: 4.3 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278318,ZNF229,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 56.7568% (minimum 75%, Baseline (adaptation disabled)); amygdala: 65.6250% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 60.0000% (minimum 75%, Baseline (adaptation disabled)); cerebellum: 70.0000% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 61.7647% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 60.0000% (minimum 75%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 70.0000% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 65.6250% (minimum 75%, Baseline (adaptation disabled)); kidney: 72.4138% (minimum 75%, Baseline (adaptation disabled)); midbrain: 65.6250% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 44.6809% (minimum 70%, Baseline (adaptation disabled)); pituitary gland: 63.6364% (minimum 75%, Baseline (adaptation disabled)); retina: 32.8125% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 72.4138% (minimum 75%, Baseline (adaptation disabled)); spinal cord: 70.0000% (minimum 75%, Baseline (adaptation disabled)); thyroid gland: 52.5000% (minimum 65%, Baseline (adaptation disabled)); tongue: 65.6250% (minimum 70%, Baseline (adaptation disabled))",-0.125,-0.253191,-0.421875,0,80,unavailable,4.3,2.6,1.9,"retina: 4.3 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000278318,ZNF229,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 98.0000% (minimum 99%, Missing); retina: 98.0000% (minimum 99%, Missing)",0.0107843,0.03,-0.01,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278522,POTEB3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.310784,0.3,0.23,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278522,POTEB3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.310784,0.3,0.23,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278522,POTEB3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.310784,0.3,0.23,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278522,POTEB3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.310784,0.3,0.23,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278522,POTEB3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skeletal muscle: 97.7273% (minimum 99%, Missing)",0.05,0.03,-0.0127273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278685,IQCA1L,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.227273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278685,IQCA1L,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.227273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278685,IQCA1L,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.227273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278685,IQCA1L,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.227273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000278685,IQCA1L,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000279169,PRAMEF13,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000279169,PRAMEF13,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000279169,PRAMEF13,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000279169,PRAMEF13,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000279169,PRAMEF13,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000279408,OR4N4C,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000279408,OR4N4C,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000279408,OR4N4C,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000279408,OR4N4C,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000279408,OR4N4C,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000282419,TEX13D,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000282419,TEX13D,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000282419,TEX13D,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000282419,TEX13D,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000282419,TEX13D,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000282815,TEX13C,admission_only,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000282815,TEX13C,selectivity_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000282815,TEX13C,grid_revised,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000282815,TEX13C,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000282815,TEX13C,current_fixed,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 46.6667% (minimum 99%, Missing); basal ganglia: 12.9630% (minimum 99%, Missing); cerebral cortex: 53.8462% (minimum 99%, Missing); hippocampal formation: 58.3333% (minimum 99%, Missing); hypothalamus: 13.2075% (minimum 99%, Missing); midbrain: 53.8462% (minimum 99%, Missing); pituitary gland: 77.7778% (minimum 99%, Missing); spinal cord: 77.7778% (minimum 99%, Missing)",0.05,0.03,-0.86037,0,80,unavailable,4.7,0,0,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283093,CENPVL2,admission_only,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 46.6667% (minimum 75%, Missing); basal ganglia: 12.9630% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 13.2075% (minimum 75%, Missing); midbrain: 53.8462% (minimum 75%, Missing)",0.35,0.3,-0.62037,0,80,unavailable,4.7,0,0,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283093,CENPVL2,selectivity_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 46.6667% (minimum 75%, Missing); basal ganglia: 12.9630% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 13.2075% (minimum 75%, Missing); midbrain: 53.8462% (minimum 75%, Missing)",0.35,0.3,-0.62037,0,80,unavailable,4.7,0,0,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283093,CENPVL2,grid_revised,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 46.6667% (minimum 75%, Missing); basal ganglia: 12.9630% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 13.2075% (minimum 75%, Missing); midbrain: 53.8462% (minimum 75%, Missing)",0.35,0.3,-0.62037,0,80,unavailable,4.7,0,0,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283093,CENPVL2,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 46.6667% (minimum 75%, Baseline (adaptation disabled)); basal ganglia: 12.9630% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 53.8462% (minimum 75%, Baseline (adaptation disabled)); hippocampal formation: 58.3333% (minimum 75%, Baseline (adaptation disabled)); hypothalamus: 13.2075% (minimum 75%, Baseline (adaptation disabled)); midbrain: 53.8462% (minimum 75%, Baseline (adaptation disabled))",0.35,0.3,-0.62037,0,80,unavailable,4.7,0,0,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283093,CENPVL2,current_fixed,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.0130508,0.01,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283205,ENSG00000283205,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.283051,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283205,ENSG00000283205,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.283051,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283205,ENSG00000283205,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.283051,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283205,ENSG00000283205,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.283051,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283205,ENSG00000283205,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pituitary gland: 98.5488% (minimum 99%, Missing)",0.0380952,0.00647059,-0.00451187,0,80,unavailable,1.1,1.8,0.9,"pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283268,TEX54,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.338095,0.276471,0.235488,0,80,unavailable,1.1,1.8,0.9,"pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283268,TEX54,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.338095,0.276471,0.235488,0,80,unavailable,1.1,1.8,0.9,"pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283268,TEX54,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.338095,0.276471,0.235488,0,80,unavailable,1.1,1.8,0.9,"pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283268,TEX54,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.338095,0.276471,0.235488,0,80,unavailable,1.1,1.8,0.9,"pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283268,TEX54,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283434,CSNK2A2IP,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283434,CSNK2A2IP,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283434,CSNK2A2IP,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283434,CSNK2A2IP,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283434,CSNK2A2IP,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283439,SPEM3,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283439,SPEM3,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283439,SPEM3,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283439,SPEM3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283439,SPEM3,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 84.3931% (minimum 99%, Missing); heart muscle: 98.6486% (minimum 99%, Missing); liver: 98.6486% (minimum 99%, Missing); pancreas: 98.6486% (minimum 99%, Missing); pituitary gland: 98.6486% (minimum 99%, Missing); retina: 98.6486% (minimum 99%, Missing)",0.0364865,0.0231973,-0.146069,0,80,unavailable,2.7,0.1,0.2,"adrenal gland: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283463,HSFX4,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.336486,0.293197,0.0939306,0,80,unavailable,2.7,0.1,0.2,"adrenal gland: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283463,HSFX4,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.336486,0.293197,0.0939306,0,80,unavailable,2.7,0.1,0.2,"adrenal gland: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283463,HSFX4,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.336486,0.293197,0.0939306,0,80,unavailable,2.7,0.1,0.2,"adrenal gland: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283463,HSFX4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.336486,0.293197,0.0939306,0,80,unavailable,2.7,0.1,0.2,"adrenal gland: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283463,HSFX4,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 95.8333% (minimum 99%, Missing); pituitary gland: 97.1831% (minimum 99%, Missing)",0.05,0.03,-0.0316667,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283516,LITAFD,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283516,LITAFD,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283516,LITAFD,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283516,LITAFD,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283516,LITAFD,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283594,FAM236C,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283594,FAM236C,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283594,FAM236C,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283594,FAM236C,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283594,FAM236C,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.7654% (minimum 99%, Missing); cerebral cortex: 97.5610% (minimum 99%, Missing); choroid plexus: 98.7654% (minimum 99%, Missing)",0.05,0.03,-0.0143902,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283599,ENSG00000283599,admission_only,True,False,False,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.22561,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283599,ENSG00000283599,selectivity_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.22561,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283599,ENSG00000283599,grid_revised,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.22561,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283599,ENSG00000283599,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Gong 2021 · reproductive coding
True,compatible,,True,True,True,,0.35,0.3,0.22561,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283599,ENSG00000283599,current_fixed,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 92.1053% (minimum 99%, Missing); heart muscle: 97.9021% (minimum 99%, Missing); pituitary gland: 98.5915% (minimum 99%, Missing)",0.029021,0.03,-0.0689474,0,80,unavailable,1.2,0,0.3,"adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283697,HSFX3,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.329021,0.3,0.171053,0,80,unavailable,1.2,0,0.3,"adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283697,HSFX3,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.329021,0.3,0.171053,0,80,unavailable,1.2,0,0.3,"adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283697,HSFX3,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.329021,0.3,0.171053,0,80,unavailable,1.2,0,0.3,"adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283697,HSFX3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.329021,0.3,0.171053,0,80,unavailable,1.2,0,0.3,"adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283697,HSFX3,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283758,PMIS2,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283758,PMIS2,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283758,PMIS2,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283758,PMIS2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283758,PMIS2,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 98.8506% (minimum 99%, Missing); basal ganglia: 96.6292% (minimum 99%, Missing); cerebellum: 98.8506% (minimum 99%, Missing); cerebral cortex: 98.8506% (minimum 99%, Missing); choroid plexus: 98.8506% (minimum 99%, Missing); hippocampal formation: 98.8506% (minimum 99%, Missing); hypothalamus: 98.8506% (minimum 99%, Missing); midbrain: 98.8506% (minimum 99%, Missing); pituitary gland: 98.8506% (minimum 99%, Missing); skeletal muscle: 96.6292% (minimum 99%, Missing)",0.05,0.0185057,-0.0237079,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284188,C1orf202,admission_only,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.288506,0.216292,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284188,C1orf202,selectivity_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.288506,0.216292,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284188,C1orf202,grid_revised,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.288506,0.216292,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284188,C1orf202,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.288506,0.216292,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284188,C1orf202,current_fixed,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284609,OR8B3,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284609,OR8B3,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284609,OR8B3,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284609,OR8B3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284609,OR8B3,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.05,0.03,0.01,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000284680,OR8B2,admission_only,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000284680,OR8B2,selectivity_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000284680,OR8B2,grid_revised,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000284680,OR8B2,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000284680,OR8B2,current_fixed,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.05,0.03,0.01,9,4,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284701,TMEM247,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,4,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284701,TMEM247,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,4,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284701,TMEM247,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,4,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284701,TMEM247,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,4,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284701,TMEM247,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284723,OR8S1,admission_only,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284723,OR8S1,selectivity_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284723,OR8S1,grid_revised,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284723,OR8S1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000284723,OR8S1,current_fixed,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5424% (minimum 95%, Missing); adrenal gland: 42.4658% (minimum 99%, Missing); bone marrow: 58.4906% (minimum 99%, Missing); cerebral cortex: 63.2653% (minimum 99%, Missing); choroid plexus: 58.4906% (minimum 99%, Missing); colon: 44.9275% (minimum 97%, Missing); duodenum: 54.3860% (minimum 99%, Missing); esophagus: 47.6923% (minimum 97%, Missing); heart muscle: 38.7500% (minimum 99%, Missing); kidney: 46.9697% (minimum 99%, Missing); liver: 36.4706% (minimum 99%, Missing); lung: 62.0000% (minimum 98%, Approved); lymph node: 59.6154% (minimum 95%, Approved); pancreas: 63.2653% (minimum 99%, Missing); parathyroid gland: 51.6667% (minimum 97%, Missing); rectum: 50.0000% (minimum 97%, Missing); retina: 41.3333% (minimum 99%, Missing); salivary gland: 47.6923% (minimum 97%, Missing); skeletal muscle: 26.9565% (minimum 99%, Missing); skin: 59.6154% (minimum 95%, Missing); small intestine: 70.4545% (minimum 99%, Missing); smooth muscle: 62.0000% (minimum 98%, Approved); spleen: 60.7843% (minimum 95%, Missing); stomach: 45.5882% (minimum 97%, Missing); thymus: 60.7843% (minimum 95%, Missing); thyroid gland: 31.9588% (minimum 95%, Missing); tongue: 67.3913% (minimum 97%, Missing); urinary bladder: 55.3571% (minimum 97%, Missing)",-0.630412,-0.520725,-0.720435,9,5,partial,8.4,3.8,6.6,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); kidney: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000284770,TBCE,admission_only,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5424% (minimum 65%, Missing); adrenal gland: 42.4658% (minimum 75%, Missing); bone marrow: 58.4906% (minimum 75%, Missing); cerebral cortex: 63.2653% (minimum 75%, Missing); choroid plexus: 58.4906% (minimum 75%, Missing); colon: 44.9275% (minimum 70%, Missing); duodenum: 54.3860% (minimum 75%, Missing); esophagus: 47.6923% (minimum 70%, Missing); heart muscle: 38.7500% (minimum 75%, Missing); kidney: 46.9697% (minimum 75%, Missing); liver: 36.4706% (minimum 75%, Missing); lung: 62.0000% (minimum 70%, Approved); lymph node: 59.6154% (minimum 65%, Approved); pancreas: 63.2653% (minimum 75%, Missing); parathyroid gland: 51.6667% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 41.3333% (minimum 75%, Missing); salivary gland: 47.6923% (minimum 70%, Missing); skeletal muscle: 26.9565% (minimum 75%, Missing); skin: 59.6154% (minimum 65%, Missing); small intestine: 70.4545% (minimum 75%, Missing); smooth muscle: 62.0000% (minimum 70%, Approved); spleen: 60.7843% (minimum 65%, Missing); stomach: 45.5882% (minimum 70%, Missing); thymus: 60.7843% (minimum 65%, Missing); thyroid gland: 31.9588% (minimum 65%, Missing); tongue: 67.3913% (minimum 70%, Missing); urinary bladder: 55.3571% (minimum 70%, Missing)",-0.330412,-0.250725,-0.480435,9,5,partial,8.4,3.8,6.6,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); kidney: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000284770,TBCE,selectivity_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5424% (minimum 65%, Missing); adrenal gland: 42.4658% (minimum 75%, Missing); bone marrow: 58.4906% (minimum 75%, Missing); cerebral cortex: 63.2653% (minimum 75%, Missing); choroid plexus: 58.4906% (minimum 75%, Missing); colon: 44.9275% (minimum 70%, Missing); duodenum: 54.3860% (minimum 75%, Missing); esophagus: 47.6923% (minimum 70%, Missing); heart muscle: 38.7500% (minimum 75%, Missing); kidney: 46.9697% (minimum 75%, Missing); liver: 36.4706% (minimum 75%, Missing); lung: 62.0000% (minimum 70%, Approved); lymph node: 59.6154% (minimum 65%, Approved); pancreas: 63.2653% (minimum 75%, Missing); parathyroid gland: 51.6667% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 41.3333% (minimum 75%, Missing); salivary gland: 47.6923% (minimum 70%, Missing); skeletal muscle: 26.9565% (minimum 75%, Missing); skin: 59.6154% (minimum 65%, Missing); small intestine: 70.4545% (minimum 75%, Missing); smooth muscle: 62.0000% (minimum 70%, Approved); spleen: 60.7843% (minimum 65%, Missing); stomach: 45.5882% (minimum 70%, Missing); thymus: 60.7843% (minimum 65%, Missing); thyroid gland: 31.9588% (minimum 65%, Missing); tongue: 67.3913% (minimum 70%, Missing); urinary bladder: 55.3571% (minimum 70%, Missing)",-0.330412,-0.250725,-0.480435,9,5,partial,8.4,3.8,6.6,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); kidney: 3.5 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); duodenum: 2.6 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000284770,TBCE,grid_revised,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5424% (minimum 65%, Missing); adrenal gland: 42.4658% (minimum 75%, Missing); bone marrow: 58.4906% (minimum 75%, Missing); cerebral cortex: 63.2653% (minimum 75%, Missing); choroid plexus: 58.4906% (minimum 75%, Missing); colon: 44.9275% (minimum 70%, Missing); duodenum: 54.3860% (minimum 75%, Missing); esophagus: 47.6923% (minimum 70%, Missing); heart muscle: 38.7500% (minimum 75%, Missing); kidney: 46.9697% (minimum 75%, Missing); liver: 36.4706% (minimum 75%, Missing); lung: 62.0000% (minimum 70%, Approved); lymph node: 59.6154% (minimum 65%, Approved); pancreas: 63.2653% (minimum 75%, Missing); parathyroid gland: 51.6667% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 41.3333% (minimum 75%, Missing); salivary gland: 47.6923% (minimum 70%, Missing); skeletal muscle: 26.9565% (minimum 75%, Missing); skin: 59.6154% (minimum 65%, Missing); small intestine: 70.4545% (minimum 75%, Missing); smooth muscle: 62.0000% (minimum 70%, Approved); spleen: 60.7843% (minimum 65%, Missing); stomach: 45.5882% (minimum 70%, Missing); thymus: 60.7843% (minimum 65%, Missing); thyroid gland: 31.9588% (minimum 65%, Missing); tongue: 67.3913% (minimum 70%, Missing); urinary bladder: 55.3571% (minimum 70%, Missing)",-0.330412,-0.250725,-0.480435,9,5,partial,8.4,3.8,6.6,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); kidney: 3.5 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); duodenum: 2.6 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000284770,TBCE,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5424% (minimum 65%, Baseline (adaptation disabled)); adrenal gland: 42.4658% (minimum 75%, Baseline (adaptation disabled)); bone marrow: 58.4906% (minimum 75%, Baseline (adaptation disabled)); cerebral cortex: 63.2653% (minimum 75%, Baseline (adaptation disabled)); choroid plexus: 58.4906% (minimum 75%, Baseline (adaptation disabled)); colon: 44.9275% (minimum 70%, Baseline (adaptation disabled)); duodenum: 54.3860% (minimum 75%, Baseline (adaptation disabled)); esophagus: 47.6923% (minimum 70%, Baseline (adaptation disabled)); heart muscle: 38.7500% (minimum 75%, Baseline (adaptation disabled)); kidney: 46.9697% (minimum 75%, Baseline (adaptation disabled)); liver: 36.4706% (minimum 75%, Baseline (adaptation disabled)); lung: 62.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 59.6154% (minimum 70%, Baseline (adaptation disabled)); pancreas: 63.2653% (minimum 75%, Baseline (adaptation disabled)); parathyroid gland: 51.6667% (minimum 70%, Baseline (adaptation disabled)); rectum: 50.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 41.3333% (minimum 75%, Baseline (adaptation disabled)); salivary gland: 47.6923% (minimum 70%, Baseline (adaptation disabled)); skeletal muscle: 26.9565% (minimum 75%, Baseline (adaptation disabled)); skin: 59.6154% (minimum 65%, Baseline (adaptation disabled)); small intestine: 70.4545% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 62.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 60.7843% (minimum 65%, Baseline (adaptation disabled)); stomach: 45.5882% (minimum 70%, Baseline (adaptation disabled)); thymus: 60.7843% (minimum 65%, Baseline (adaptation disabled)); thyroid gland: 31.9588% (minimum 65%, Baseline (adaptation disabled)); tongue: 67.3913% (minimum 70%, Baseline (adaptation disabled)); urinary bladder: 55.3571% (minimum 70%, Baseline (adaptation disabled))",-0.330412,-0.250725,-0.480435,9,5,partial,8.4,3.8,6.6,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); kidney: 3.5 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); duodenum: 2.6 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000284770,TBCE,current_fixed,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"adipose tissue: 60.0000% (minimum 95%, Missing); bone marrow: 5.6604% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 75.0000% (minimum 97%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 17.6471% (minimum 97%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); rectum: 50.0000% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); skin: 37.5000% (minimum 95%, Missing); small intestine: 50.0000% (minimum 99%, Missing); smooth muscle: 60.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 42.8571% (minimum 97%, Missing); thymus: 17.6471% (minimum 95%, Missing); thyroid gland: 75.0000% (minimum 95%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",-0.773529,-0.793529,-0.933396,9,80,unavailable,5,1.4,1.4,"bone marrow: 5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000285077,ARHGAP11B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); bone marrow: 5.6604% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 17.6471% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 75.0000% (minimum 75%, Missing); skin: 37.5000% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thymus: 17.6471% (minimum 65%, Missing)",-0.473529,-0.523529,-0.693396,9,80,unavailable,5,1.4,1.4,"bone marrow: 5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000285077,ARHGAP11B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); bone marrow: 5.6604% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 17.6471% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 75.0000% (minimum 75%, Missing); skin: 37.5000% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thymus: 17.6471% (minimum 65%, Missing)",-0.473529,-0.523529,-0.693396,9,80,unavailable,5,1.4,1.4,"bone marrow: 5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000285077,ARHGAP11B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); bone marrow: 5.6604% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 17.6471% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 75.0000% (minimum 75%, Missing); skin: 37.5000% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thymus: 17.6471% (minimum 65%, Missing)",-0.473529,-0.523529,-0.693396,9,80,unavailable,5,1.4,1.4,"bone marrow: 5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000285077,ARHGAP11B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Baseline (adaptation disabled)); bone marrow: 5.6604% (minimum 75%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 70%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 75%, Baseline (adaptation disabled)); liver: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 75%, Baseline (adaptation disabled)); lymph node: 17.6471% (minimum 70%, Baseline (adaptation disabled)); rectum: 50.0000% (minimum 70%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 75%, Baseline (adaptation disabled)); skin: 37.5000% (minimum 65%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 75%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 75%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 65%, Baseline (adaptation disabled)); stomach: 42.8571% (minimum 70%, Baseline (adaptation disabled)); thymus: 17.6471% (minimum 65%, Baseline (adaptation disabled))",-0.473529,-0.523529,-0.693396,9,80,unavailable,5,1.4,1.4,"bone marrow: 5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000285077,ARHGAP11B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000293137,MSL3B,admission_only,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000293137,MSL3B,selectivity_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000293137,MSL3B,grid_revised,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000293137,MSL3B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000293137,MSL3B,current_fixed,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018